Reproduction in the space environment: Part II. Concerns for human reproduction

NASA Technical Reports Server (NTRS)

Jennings, R. T.; Santy, P. A.

1990-01-01

Long-duration space flight and eventual colonization of our solar system will require successful control of reproductive function and a thorough understanding of factors unique to space flight and their impact on gynecologic and obstetric parameters. Part II of this paper examines the specific environmental factors associated with space flight and the implications for human reproduction. Space environmental hazards discussed include radiation, alteration in atmospheric pressure and breathing gas partial pressures, prolonged toxicological exposure, and microgravity. The effects of countermeasures necessary to reduce cardiovascular deconditioning, calcium loss, muscle wasting, and neurovestibular problems are also considered. In addition, the impact of microgravity on male fertility and gamete quality is explored. Due to current constraints, human pregnancy is now contraindicated for space flight. However, a program to explore effective countermeasures to current constraints and develop the required health care delivery capability for extended-duration space flight is suggested. A program of Earth- and space-based research to provide further answers to reproductive questions is suggested.

Humans and machines in space: The vision, the challenge, the payoff; Proceedings of the 29th Goddard Memorial Symposium, Washington, Mar. 14, 15, 1991

NASA Astrophysics Data System (ADS)

Johnson, Bradley; May, Gayle L.; Korn, Paula

The present conference discusses the currently envisioned goals of human-machine systems in spacecraft environments, prospects for human exploration of the solar system, and plausible methods for meeting human needs in space. Also discussed are the problems of human-machine interaction in long-duration space flights, remote medical systems for space exploration, the use of virtual reality for planetary exploration, the alliance between U.S. Antarctic and space programs, and the economic and educational impacts of the U.S. space program.

AST commercial human space flight biomedical data collection

DOT National Transportation Integrated Search

2007-02-01

Recommendations are made for specific biomedical data, equipment, and a database that will increase the knowledge and understanding of how short duration, suborbital space flight missions with brief exposure to microgravity affects the human body. Th...

Fluid Shifts Before, During and After Prolonged Space Flight and Their Association with Intracranial Pressure and Visual Impairment

NASA Technical Reports Server (NTRS)

Stenger, Michael; Hargens, Alan; Dulchavsky, Scott

2014-01-01

Future human space travel will primarily consist of long duration missions onboard the International Space Station or exploration class missions to Mars, its moons, or nearby asteroids. Current evidence suggests that long duration missions might increase risk of permanent ocular structural and functional changes, possibly due to increased intracranial pressure resulting from a spaceflight-induced cephalad (headward) fluid shift.

Water: A Critical Material Enabling Space Exploration

NASA Technical Reports Server (NTRS)

Pickering, Karen D.

2014-01-01

Water is one of the most critical materials in human spaceflight. The availability of water defines the duration of a space mission; the volume of water required for a long-duration space mission becomes too large, heavy, and expensive for launch vehicles to carry. Since the mission duration is limited by the amount of water a space vehicle can carry, the capability to recycle water enables space exploration. In addition, water management in microgravity impacts spaceflight in other respects, such as the recent emergency termination of a spacewalk caused by free water in an astronaut's spacesuit helmet. A variety of separation technologies are used onboard spacecraft to ensure that water is always available for use, and meets the stringent water quality required for human space exploration. These separation technologies are often adapted for use in a microgravity environment, where water behaves in unique ways. The use of distillation, membrane processes, ion exchange and granular activated carbon will be reviewed. Examples of microgravity effects on operations will also be presented. A roadmap for future technologies, needed to supply water resources for the exploration of Mars, will also be reviewed.

Integrated Human-in-the-Loop Ground Testing - Value, History, and the Future

NASA Technical Reports Server (NTRS)

Henninger, Donald L.

2016-01-01

Systems for very long-duration human missions to Mars will be designed to operate reliably for many years and many of these systems will never be returned to Earth. The need for high reliability is driven by the requirement for safe functioning of remote, long-duration crewed systems and also by unsympathetic abort scenarios. Abort from a Mars mission could be as long as 450 days to return to Earth. The key to developing a human-in-the-loop architecture is a development process that allows for a logical sequence of validating successful development in a stepwise manner, with assessment of key performance parameters (KPPs) at each step; especially important are KPPs for technologies evaluated in a full systems context with human crews on Earth and on space platforms such as the ISS. This presentation will explore the implications of such an approach to technology development and validation including the roles of ground and space-based testing necessary to develop a highly reliable system for long duration human exploration missions. Historical development and systems testing from Mercury to the International Space Station (ISS) to ground testing will be reviewed. Current work as well as recommendations for future work will be described.

Human Space Flight

NASA Technical Reports Server (NTRS)

Woolford, Barbara; Mount, Frances

2004-01-01

The first human space flight, in the early 1960s, was aimed primarily at determining whether humans could indeed survive and function in micro-gravity. Would eating and sleeping be possible? What mental and physical tasks could be performed? Subsequent programs increased the complexity of the tasks the crew performed. Table 1 summarizes the history of U.S. space flight, showing the projects, their dates, crew sizes, and mission durations. With over forty years of experience with human space flight, the emphasis now is on how to design space vehicles, habitats, and missions to produce the greatest returns to human knowledge. What are the roles of the humans in space flight in low earth orbit, on the moon, and in exploring Mars?

Future In-Space Operations (FISO): A Working Group and Community Engagement

NASA Technical Reports Server (NTRS)

Thronson, Harley; Lester, Dan

2013-01-01

Long-duration human capabilities beyond low Earth orbit (LEO), either in support of or as an alternative to lunar surface operations, have been assessed at least since the late 1960s. Over the next few months, we will present short histories of concepts for long-duration, free-space human habitation beyond LEO from the end of the Apollo program to the Decadal Planning Team (DPT)/NASA Exploration Team (NExT), which was active in 1999 2000 (see Forging a vision: NASA s Decadal Planning Team and the origins of the Vision for Space Exploration , The Space Review, December 19, 2005). Here we summarize the brief existence of the Future In-Space Operations (FISO) working group in 2005 2006 and its successor, a telecon-based colloquium series, which we co-moderate.

A Large Radius Human Centrifuge: The Human Hypergravity Havitat

NASA Astrophysics Data System (ADS)

van Loon, J. J. W. A.

2008-06-01

Life on Earth has developed at unit gravity, 9.81 m/s2, but how would plants and animals have evolved on a larger planet, i.e. larger than Earth? We are able to address this question simply by studies using centrifuges. In the past decades numerous experiments have been performed on cells, plants and animals grown for longer durations, even multi generations, under hypergravity conditions. Based on these studies we have gained interesting insights in the physiological process of these systems when exposed to artificial gravity. Animals and plants adapt themselves to this new high-g environment. Information of adaptation to hyper-g in mammals is interesting, or maybe even proof vital, for future human space flight programs especially in light of long duration missions to Moon and Mars. We know from long duration animal studies that numerous physiological processes and structures like muscles, bones, neuro-vestibular, or the cardiovascular system are affected. However, humans have never been exposed to a hyper-g environment for long durations. Human studies are mostly in the order of hours at most. Current work on human centrifuges is all focused on short arm systems to apply artificial gravity in long duration space missions. In this paper we want to address the possible usefulness of a large radius human centrifuge on Earth, or even on Moon or Mars, for both basic research and possible applications. In such a centrifuge a group of humans may be exposed to hypergravity for, in principle, an unlimited period of time.

Issues on human acceleration tolerance after long-duration space flights

NASA Technical Reports Server (NTRS)

Kumar, K. Vasantha; Norfleet, William T.

1992-01-01

This report reviewed the literature on human tolerance to acceleration at 1 G and changes in tolerance after exposure to hypogravic fields. It was found that human tolerance decreased after exposure to hypokinetic and hypogravic fields, but the magnitude of such reduction ranged from 0 to 30 percent for plateau G forces and 30 to 70 percent for time tolerance on sustained G forces. A logistic regression model of the probability of individuals with 25 percent reduction in +Gz tolerance after 1 to 41 days of hypogravic exposures was constructed. The estimated values from the model showed a good correlation with the observed data. A brief review of the need for in-flight centrifuge during long-duration missions was also presented. Review of the available data showed that the use of countermeasures (such as anti-G suits, periodic acceleration, and exercise) reduced the decrement in acceleration tolerance after long-duration space flights. Areas of further research include quantification of the effect of countermeasures on tolerance, and methods to augment tolerance during and after exposures to hypogravic fields. Such data are essential for planning long-duration human missions.

LSG_Broll

NASA Image and Video Library

2018-05-15

NASA engineers discussed the Life Sciences Glovebox, the agency's newest research facility for the International Space Station today at Marshall Space Flight Center in Huntsville, Alabama. The Life Sciences Glovebox will be used to study the long-term impact of microgravity on human physiology, revealing new ways to improve life on Earth while protecting human explorers during long-duration deep space missions.

The effect of spaceflight and microgravity on the human brain.

PubMed

Van Ombergen, Angelique; Demertzi, Athena; Tomilovskaya, Elena; Jeurissen, Ben; Sijbers, Jan; Kozlovskaya, Inessa B; Parizel, Paul M; Van de Heyning, Paul H; Sunaert, Stefan; Laureys, Steven; Wuyts, Floris L

2017-10-01

Microgravity, confinement, isolation, and immobilization are just some of the features astronauts have to cope with during space missions. Consequently, long-duration space travel can have detrimental effects on human physiology. Although research has focused on the cardiovascular and musculoskeletal system in particular, the exact impact of spaceflight on the human central nervous system remains to be determined. Previous studies have reported psychological problems, cephalic fluid shifts, neurovestibular problems, and cognitive alterations, but there is paucity in the knowledge of the underlying neural substrates. Previous space analogue studies and preliminary spaceflight studies have shown an involvement of the cerebellum, cortical sensorimotor, and somatosensory areas and the vestibular pathways. Extending this knowledge is crucial, especially in view of long-duration interplanetary missions (e.g., Mars missions) and space tourism. In addition, the acquired insight could be relevant for vestibular patients, patients with neurodegenerative disorders, as well as the elderly population, coping with multisensory deficit syndromes, immobilization, and inactivity.

Habitability in Advanced Space Mission Design. Part 2; Evaluation of Habitation Elements

NASA Technical Reports Server (NTRS)

Adams, Constance M.; McCurdy, Matthew R.

2000-01-01

Habitability is a fundamental component of any long-duration human habitat. Due to the pressures on the crew and the criticality of their performance, this is particularly true of habitats or vehicles proposed for use in any human space mission of duration over 30 days. This paper, the second of three on this subject, will focus on evaluating all the vehicles currently under consideration for the Mars Design Reference Mission through application of metrics for habitability (proposed in a previous paper, see references Adams/McCurdy 1999).

Science on the International Space Station: Stepping Stones for Exploration

NASA Technical Reports Server (NTRS)

Robinson, Julie A.

2007-01-01

This viewgraph presentation reviews the state of science research on the International Space Station (ISS). The shuttle and other missions that have delivered science research facilities to the ISS are shown. The different research facilities provided by both NASA and partner organizations available for use and future facilities are reviewed. The science that has been already completed is discussed. The research facilitates the Vision for Space Exploration, in Human Life Sciences, Biological Sciences, Materials Science, Fluids Science, Combustion Science, and all other sciences. The ISS Focus for NASA involves: Astronaut health and countermeasure, development to protect crews from the space environment during long duration voyages, Testing research and technology developments for future exploration missions, Developing and validating operational procedures for long-duration space missions. The ISS Medical Project (ISSMP) address both space systems and human systems. ISSMP has been developed to maximize the utilization of ISS to obtain solutions to the human health and performance problems and the associated mission risks of exploration class missions. Including complete programmatic review with medical operations (space medicine/flight surgeons) to identify: (1) evidence base on risks (2) gap analysis.

Psychological and Behavioral Health Issues of Long-Duration Space Missions

NASA Technical Reports Server (NTRS)

Eksuzian, Daniel J.

1998-01-01

It will be the responsibility of the long-duration space flight crew to take the actions necessary to maintain their health and well-being and to cope with medical emergencies without direct assistance from support personnel, including maintaining mental health and managing physiological and psychological changes that may impair decision making and performance. The Behavior and Performance Integrated Product Team at Johnson Space Center, working, within the Space Medicine, Monitoring, and Countermeasures Program, has identified critical questions pertaining to long-duration space crew behavioral health, psychological adaptation, human factors and habitability, and sleep and circadian rhythms. Among the projects addressing these questions are: the development of tools to assess cognitive functions during space missions; the development of a model of psychological adaptation in isolated and confined environments; tools and methods for selecting individuals and teams well-suited for long-duration missions; identification of mission-critical tasks and performance evaluation; and measures of sleep quality and correlation to mission performance.

The biomedical challenges of space flight

NASA Technical Reports Server (NTRS)

Williams, David R.

2003-01-01

Space medicine has evolved considerably through past U.S. missions. It has been proven that humans can live and work in space for long durations and that humans are integral to mission success. The space medicine program of the National Aeronautics and Space Administration (NASA) looks toward future long-duration missions. Its goal is to overcome the biomedical challenges associated with maintaining the safety, health, and optimum performance of astronauts and cosmonauts. This program investigates the health effects of adaptation to microgravity: the nature of their pathologies, the effects of microgravity on pathophysiology, and the alterations in pharmacodynamics and treatment. A critical capability in performing research is the monitoring of the health of all astronauts and of the spacecraft environment. These data support the evidence-based approach to space medicine, incorporating past studies of microgravity-related conditions and their terrestrial counterparts. This comprehensive approach will enable safe and effective exploration beyond low Earth orbit.

The human quest in space; Proceedings of the Twenty-fourth Goddard Memorial Symposium, Greenbelt, MD, Mar. 20, 21, 1986

NASA Technical Reports Server (NTRS)

Burdett, Gerald L. (Editor); Soffen, Gerald A. (Editor)

1987-01-01

Papers are presented on the Space Station, materials processing in space, the status of space remote sensing, the evolution of space infrastructure, and the NASA Teacher Program. Topics discussed include visionary technologies, the effect of intelligent machines on space operations, future information technology, and the role of nuclear power in future space missions. Consideration is given to the role of humans in space exploration; medical problems associated with long-duration space flights; lunar and Martian settlements, and Biosphere II (the closed ecology project).

Countermeasures to Neurobehavioral Deficits from Cumulative Partial Sleep Deprivation During Space Flight

NASA Technical Reports Server (NTRS)

Dinges, David F.

1999-01-01

This project is concerned with identifying ways to prevent neurobehavioral and physical deterioration due to inadequate sleep in astronauts during long-duration manned space flight. The performance capability of astronauts during extended-duration space flight depends heavily on achieving recovery through adequate sleep. Even with appropriate circadian alignment, sleep loss can erode fundamental elements of human performance capability including vigilance, cognitive speed and accuracy, working memory, reaction time, and physiological alertness. Adequate sleep is essential during manned space flight not only to ensure high levels of safe and effective human performance, but also as a basic regulatory biology critical to healthy human functioning. There is now extensive objective evidence that astronaut sleep is frequently restricted in space flight to averages between 4 hr and 6.5 hr/day. Chronic sleep restriction during manned space flight can occur in response to endogenous disturbances of sleep (motion sickness, stress, circadian rhythms), environmental disruptions of sleep (noise, temperature, light), and curtailment of sleep due to the work demands and other activities that accompany extended space flight operations. The mechanism through which this risk emerges is the development of cumulative homeostatic pressure for sleep across consecutive days of inadequate sleep. Research has shown that the physiological sleepiness and performance deficits engendered by sleep debt can progressively worsen (i.e., accumulate) over consecutive days of sleep restriction, and that sleep limited to levels commonly experienced by astronauts (i.e., 4 - 6 hr per night) for as little as 1 week, can result in increased lapses of attention, degradation of response times, deficits in complex problem solving, reduced learning, mood disturbance, disruption of essential neuroendocrine, metabolic, and neuroimmune responses, and in some vulnerable persons, the emergence of uncontrolled sleep attacks. The prevention of cumulative performance deficits and neuroendocrine disruption from sleep restriction during extended duration space flight involves finding the most effective ways to obtain sleep in order to maintain the high-level cognitive and physical performance functions required for manned space flight. There is currently a critical deficiency in knowledge of the effects of how variations in sleep duration and timing relate to the most efficient return of performance per unit time invested in sleep during long-duration missions, and how the nature of sleep physiology (i.e., sleep stages, sleep electroencephalographic [EEG] power spectral analyses) change as a function of sleep restriction and performance degradation. The primary aim of this project is to meet these critical deficiencies through utilization of a response surface experimental paradigm, testing in a dose-response manner, varying combinations of sleep duration and timing, for the purpose of establishing how to most effectively limit the cumulative adverse effects on human performance and physiology of chronic sleep restriction in space operations.

Advanced Water Recovery Technologies for Long Duration Space Exploration Missions

NASA Technical Reports Server (NTRS)

Liu, Scan X.

2005-01-01

Extended-duration space travel and habitation require recovering water from wastewater generated in spacecrafts and extraterrestrial outposts since the largest consumable for human life support is water. Many wastewater treatment technologies used for terrestrial applications are adoptable to extraterrestrial situations but challenges remain as constraints of space flights and habitation impose severe limitations of these technologies. Membrane-based technologies, particularly membrane filtration, have been widely studied by NASA and NASA-funded research groups for possible applications in space wastewater treatment. The advantages of membrane filtration are apparent: it is energy-efficient and compact, needs little consumable other than replacement membranes and cleaning agents, and doesn't involve multiphase flow, which is big plus for operations under microgravity environment. However, membrane lifespan and performance are affected by the phenomena of concentration polarization and membrane fouling. This article attempts to survey current status of membrane technologies related to wastewater treatment and desalination in the context of space exploration and quantify them in terms of readiness level for space exploration. This paper also makes specific recommendations and predictions on how scientist and engineers involving designing, testing, and developing space-certified membrane-based advanced water recovery technologies can improve the likelihood of successful development of an effective regenerative human life support system for long-duration space missions.

Habitability and performance issues for long duration space flights.

PubMed

Whitmore, M; McQuilkin, M L; Woolford, B J

1998-09-01

Advancing technology, coupled with the desire to explore space has resulted in increasingly longer manned space missions. Although the Long Duration Space Flights (LDSF) have provided a considerable amount of scientific research on human ability to function in extreme environments, findings indicate long duration missions take a toll on the individual, both physiologically and psychologically. These physiological and psychological issues manifest themselves in performance decrements; and could lead to serious errors endangering the mission, spacecraft and crew. The purpose of this paper is threefold: 1) to document existing knowledge of the effects of LDSF on performance, habitability, and workload, 2) to identify and assess potential tools designed to address these decrements, and 3) to propose an implementation plan to address these habitability, performance and workload issues.

Habitability and Performance Issues for Long Duration Space Flights

NASA Technical Reports Server (NTRS)

Whitmore, Mihriban; McQuilkin, Meredith L.; Woolford, Barbara J.

1997-01-01

Advancing technology, coupled with the desire to explore space has resulted in increasingly longer manned space missions. Although the Long Duration Space Flights (LDSF) have provided a considerable amount of scientific research on human ability to function in extreme environments, findings indicate long duration missions take a toll on the individual, both physiologically and psychologically. These physiological and psychological issues manifest themselves in performance decrements; and could lead to serious errors endangering the mission, spacecraft and crew. The purpose of this paper is to document existing knowledge of the effects of LDSF on performance, habitability, and workload and to identify and assess potential tools designed to address these decrements as well as propose an implementation plan to address the habitability, performance and workload issues.

The contributions of occupational science to the readiness of long duration deep space exploration.

PubMed

Davis, Janis; Burr, Macy; Absi, Maria; Telles, Rochelle; Koh, Howard

2017-01-01

This study introduces the contributions of occupational science (OS) to the preparation and support of astronauts during long duration space exploration. Given the hostile environment of space, it is not surprising that there is grave deterioration of both physical and mental health when off Earth. However, OS, through occupational therapy (OT), can identify strategies that maintain health and minimize disruptions in task performance for mission success. To determine the gaps in NASA's preparation of astronauts for long duration space exploration and the viable contributions of OT. Because occupational therapists are trained to address deficits and modify environments to support meaningful engagement in occupations, the OT practitioner is well suited to address the disabling conditions astronauts experience in space. A literature review revealing the challenges of deep space travel on humans was completed. A survey was also sent to (N = 170) occupational therapists worldwide to identify opinions about the profession's involvement in deep space exploration. Ninety-seven percent (N = 163) of the participants believed that OS can inform long duration space travel. Approximately ninety-eight percent (N = 166) of respondents believed that OT interventions can be used on space travelers during long duration space flights. OT interventions can be implemented in any phase of space flight to increase the likelihood of mission success and astronaut safety and well-being.

Problems in water recycling for Space Station Freedom and long duration life support

NASA Technical Reports Server (NTRS)

Janik, D. S.; Crump, W. J.; Macler, B. A.; Wydeven, T., Jr.; Sauer, R. L.

1989-01-01

A biologically-enhanced, physical/chemical terminal water treatment testbed for the Space Station Freedom is proposed. Recycled water requirements for human, animal, plant and/or combined crews for long duration space missions are discussed. An effective terminal treatment method for recycled water reclamation systems that is based on using granular activated carbon as the principal active agent and the controls of microbial contamination and growth within recycled water systems are examined. The roles of plants in water recycling within CELSS is studied.

Lunar base as a precursor to Mars exploration and settlement

NASA Technical Reports Server (NTRS)

Mendell, Wendell W.

1991-01-01

A well planned program of human exploration of the moon is suggested which would provide a base for increasing human capabilities and experience to levels required for Mars exploration. A strategy intended for immediate Mars exploration and settlement is considered to incur serious programmatic risks from current lack of knowledge on human performance on long-duration deep space missions and lack of experience in designing human space systems. The lunar program provides an opportunity to build up space capability in an evolutionary way and to broaden the participation of the educational system in the space exploration.

[Musculoskeletal rehabilitation and bone. Musculoskeletal response to human space flight and physical countermeasures].

PubMed

Ohshima, Hiroshi

2010-04-01

The assembly of the Japanese Experiment Module "Kibo" to international space station was completed in 2009 and Koichi Wakata became the first Japanese station astronaut who spent more than 4 months in the station. Bone and muscle losses are significant medical concerns for long duration human space flight. Effective countermeasure program for bone loss and muscle atrophy is necessary to avoid post flight bone fracture and joint sprain after landing. The musculoskeletal response to human space flight and current physical countermeasure program for station astronauts are described.

Concepts for a Shroud or Propellant Tank Derived Deep Space Habitat

NASA Technical Reports Server (NTRS)

Howard, Robert L.

2012-01-01

Long duration human spaceflight missions beyond Low Earth Orbit will require much larger spacecraft than capsules such as the Russian Soyuz or American Orion Multi-Purpose Crew Vehicle. A concept spacecraft under development is the Deep Space Habitat, with volumes approaching that of space stations such as Skylab, Mir, and the International Space Station. This paper explores several concepts for Deep Space Habitats constructed from a launch vehicle shroud or propellant tank. It also recommends future research using mockups and prototypes to validate the size and crew station capabilities of such a habitat. Keywords: Exploration, space station, lunar outpost, NEA, habitat, long duration, deep space habitat, shroud, propellant tank.

The Life Cycle Cost (LCC) of Life Support Recycling and Resupply

NASA Technical Reports Server (NTRS)

Jones, Harry W.

2015-01-01

Brief human space missions supply all the crew's water and oxygen from Earth. The multiyear International Space Station (ISS) program instead uses physicochemical life support systems to recycle water and oxygen. This paper compares the Life Cycle Cost (LCC) of recycling to the LCC of resupply for potential future long duration human space missions. Recycling systems have high initial development costs but relatively low durationdependent support costs. This means that recycling is more cost effective for longer missions. Resupplying all the water and oxygen requires little initial development cost but has a much higher launch mass and launch cost. The cost of resupply increases as the mission duration increases. Resupply is therefore more cost effective than recycling for shorter missions. A recycling system pays for itself when the resupply LCC grows greater over time than the recycling LCC. The time when this occurs is called the recycling breakeven date. Recycling will cost very much less than resupply for long duration missions within the Earth-Moon system, such as a future space station or Moon base. But recycling would cost about the same as resupply for long duration deep space missions, such as a Mars trip. Because it is not possible to provide emergency supplies or quick return options on the way to Mars, more expensive redundant recycling systems will be needed.

Human health and performance considerations for near earth asteroids (NEA)

NASA Astrophysics Data System (ADS)

Steinberg, Susan; Kundrot, Craig; Charles, John

2013-11-01

Humans are considered as a system in the design of any deep space exploration mission. The addition of many potential near asteroid (NEA) destinations to the existing multiple mission architecture for Lunar and Mars missions increases the complexity of human health and performance issues that are anticipated for exploration of space. We suggest that risks to human health and performance be analyzed in terms of the 4 major parameters related to multiple mission architecture: destination, duration, distance and vehicle design. Geological properties of the NEA will influence design of exploration tasks related to sample handling and containment, and extravehicular activity (EVA) capabilities including suit ports and tools. A robotic precursor mission that collects basic information on NEA surface properties would reduce uncertainty about these aspects of the mission as well as aid in mission architecture and exploration task design. Key mission parameters are strongly impacted by duration and distance. The most critical of these is deep-space radiation exposure without even the temporary shielding of a nearby large planetary body. The current space radiation permissible exposure limits (PEL) limits mission duration to 3-10 months depending on age, gender and stage of the solar cycle. Duration also impacts mission architectures including countermeasures for bone, muscle, and cardiovascular atrophy during continuous weightlessness; and behavioral and psychological issues resulting from isolation and confinement. Distance affects communications and limits abort and return options for a NEA mission. These factors are anticipated to have important effects on crew function and autonomous operations, as well as influence medical capability, supplies and training requirements of the crew. The design of a habitat volume that can maintain the physical and psychological health of the crew and support mission operations with limited intervention from earth will require an integrated research and development effort between NASA's Human Research Program (HRP), engineering and human factors groups. Packaging food to extend shelf life and waste management will be important components of vehicle subsystem design.

Human space exploration the next fifty years.

PubMed

Williams, David R; Turnock, Matthew

2011-06-01

Preparation for the fiftieth anniversary of human spaceflight in the spring of 2011 provides the space faring nations with an opportunity to reflect on past achievements as well as consider the next fifty years of human spaceflight. The International Space Station is a unique platform for long duration life science research that will play a critical role in preparing for future human space exploration beyond low earth orbit. Some feel the future path back to the Moon and on to Mars may be delayed with the current commitment of the United States to support the development of human-rated commercial spacecraft. Others see this as a unique opportunity to leverage the capability of the private sector in expanding access to space exploration. This article provides an overview of the past achievements in human spaceflight and discusses future missions over the next fifty years and the role space medicine will play in extending the time-distance constant of human space exploration.

Effects of space flights on human allergic status (IgE-mediated sensitivity)

NASA Astrophysics Data System (ADS)

Buravkova, L. B.; Rykova, M. P.; Gertsik, Y. G.; Antropova, E. N.

2007-02-01

Suppression of the immune system after space flights of different duration has been reported earlier by Konstantinova [Immune system in extreme conditions, Space immunology. B. 59. M. Science 1988. 289p. (in Russian) [4]; Immunoresistance of man in space flight, Acta Astronautica 23 (1991) 123-127 [5

Gravity, the third dimension of life support in space

NASA Technical Reports Server (NTRS)

Burton, Russell R.

1994-01-01

The ascent of the human into high altitudes required a 2-D life support system that supplied: oxygen, and heat. At lower altitudes, increased oxygen concentration in the inhaled gases was useful, but at higher altitudes for longer durations, this 'clever' life support approach was no longer adequate--physiologic requirements had to provide a natural pressure-based environment. In space, the life support system requires a third dimension, gravity. Although substituting for gravity has been successful on a limited number of physiologic functions for short-duration stays in space, long durations will require the effects of the real thing for critical physiologic functions. It has been known for over a hundred years that the forces of acceleration (G) and gravity are equivalent. Therefore, gravitational stimulation in space can be achieved with centrifugation. However, for this stimulation to be effective, the dosage of G required to maintain normal physiologic function must be determined. An approximation of this dosage of G for the human can be determined with 3-day bed-rest studies including periodic centrifuge exposure. Recent research on this topic is reviewed.

Validation of Procedures for Monitoring Crewmember Immune Function - Short Duration Biological Investigation

NASA Technical Reports Server (NTRS)

Sams, Clarence; Crucian, Brian; Stowe, Raymond; Pierson, Duane; Mehta, Satish; Morukov, Boris; Uchakin, Peter; Nehlsen-Cannarella, Sandra

2008-01-01

Validation of Procedures for Monitoring Crew Member Immune Function - Short Duration Biological Investigation (Integrated Immune-SDBI) will assess the clinical risks resulting from the adverse effects of space flight on the human immune system and will validate a flightcompatible immune monitoring strategy. Immune system changes will be monitored by collecting and analyzing blood, urine and saliva samples from crewmembers before, during and after space flight.

Computational Modeling of Space Physiology

NASA Technical Reports Server (NTRS)

Lewandowski, Beth E.; Griffin, Devon W.

2016-01-01

The Digital Astronaut Project (DAP), within NASAs Human Research Program, develops and implements computational modeling for use in the mitigation of human health and performance risks associated with long duration spaceflight. Over the past decade, DAP developed models to provide insights into space flight related changes to the central nervous system, cardiovascular system and the musculoskeletal system. Examples of the models and their applications include biomechanical models applied to advanced exercise device development, bone fracture risk quantification for mission planning, accident investigation, bone health standards development, and occupant protection. The International Space Station (ISS), in its role as a testing ground for long duration spaceflight, has been an important platform for obtaining human spaceflight data. DAP has used preflight, in-flight and post-flight data from short and long duration astronauts for computational model development and validation. Examples include preflight and post-flight bone mineral density data, muscle cross-sectional area, and muscle strength measurements. Results from computational modeling supplement space physiology research by informing experimental design. Using these computational models, DAP personnel can easily identify both important factors associated with a phenomenon and areas where data are lacking. This presentation will provide examples of DAP computational models, the data used in model development and validation, and applications of the model.

In-Space Structural Assembly: Applications and Technology

NASA Technical Reports Server (NTRS)

Belvin, W. Keith; Doggett, Bill R.; Watson, Judith J.; Dorsey, John T.; Warren, Jay; Jones, Thomas C.; Komendera, Erik E.; Mann, Troy O.; Bowman, Lynn

2016-01-01

As NASA exploration moves beyond earth's orbit, the need exists for long duration space systems that are resilient to events that compromise safety and performance. Fortunately, technology advances in autonomy, robotic manipulators, and modular plug-and-play architectures over the past two decades have made in-space vehicle assembly and servicing possible at acceptable cost and risk. This study evaluates future space systems needed to support scientific observatories and human/robotic Mars exploration to assess key structural design considerations. The impact of in-space assembly is discussed to identify gaps in structural technology and opportunities for new vehicle designs to support NASA's future long duration missions.

Calcium and Bone Metabolism During Spaceflight

NASA Technical Reports Server (NTRS)

Smith, Scott M.

2002-01-01

The ability to understand and counteract weightlessness-induced bone loss will be critical for crew health and safety during and after space station or exploration missions lasting months or years, respectively. Until its deorbit in 2001 , the Mir Space Station provided a valuable platform for long-duration space missions and life sciences research. Long-duration flights are critical for studying bone loss, as the 2- to 3-week Space Shuttle flights are not long enough to detect changes in bone mass. This review will describe human spaceflight data, focusing on biochemical surrogates of bone and calcium metabolism. This subject has been reviewed previously. 1-

The human cardiovascular system during space flight

NASA Astrophysics Data System (ADS)

Grigoriev, A. I.; Kotovskaya, A. R.; Fomina, G. A.

2011-05-01

Purpose of the work is to analyze and to summarize the data of investigations into human hemodynamics performed over 20 years aboard orbital stations Salyut-7 and Mir with participation of 26 cosmonauts on space flights (SF) from 8 to 438 days in duration. The ultrasonic techniques and occlusive plethysmography demonstrated dynamics of changes in the cardiovascular system during SF of various durations. The parameters of general hemodynamics, the pumping function of the heart and arterial circulation in the brain remained stable in all the space flights; however, there were alterations in peripheral circulation associated with blood redistribution and hypovolemie in microgravity. The anti-gravity distribution of the vascular tone decayed gradually as unneeded. The most considerable changes were observed in leg vessels, equally in arteries (decrease in resistance) and veins (increase in maximum capacity). The lower body negative pressure test (LBNP) revealed deterioration of the gravity-dependent reactions that changed for the worse as SF duration extended. The cardiovascular deconditioning showed itself as loss of descent acceleration tolerance and orthostatic instability in the postflight period.

Logistics Needs for Potential Deep Space Mission Scenarios Post Asteroid Redirect Crewed Mission

NASA Technical Reports Server (NTRS)

Lopez, Pedro, Jr.; Shultz, Eric; Mattfeld, Bryan; Stromgren, Chel; Goodliff, Kandyce

2015-01-01

The Asteroid Redirect Mission (ARM) is currently being explored as the next step towards deep space human exploration, with the ultimate goal of reaching Mars. NASA is currently investigating a number of potential human exploration missions, which will progressively increase the distance and duration that humans spend away from Earth. Missions include extended human exploration in cis-lunar space which, as conceived, would involve durations of around 60 days, and human missions to Mars, which are anticipated to be as long as 1000 days. The amount of logistics required to keep the crew alive and healthy for these missions is significant. It is therefore important that the design and planning for these missions include accurate estimates of logistics requirements. This paper provides a description of a process and calculations used to estimate mass and volume requirements for crew logistics, including consumables, such as food, personal items, gasses, and liquids. Determination of logistics requirements is based on crew size, mission duration, and the degree of closure of the environmental control life support system (ECLSS). Details are provided on the consumption rates for different types of logistics and how those rates were established. Results for potential mission scenarios are presented, including a breakdown of mass and volume drivers. Opportunities for mass and volume reduction are identified, along with potential threats that could possibly increase requirements.

Exploration Health Risks: Probabilistic Risk Assessment

NASA Technical Reports Server (NTRS)

Rhatigan, Jennifer; Charles, John; Hayes, Judith; Wren, Kiley

2006-01-01

Maintenance of human health on long-duration exploration missions is a primary challenge to mission designers. Indeed, human health risks are currently the largest risk contributors to the risks of evacuation or loss of the crew on long-duration International Space Station missions. We describe a quantitative assessment of the relative probabilities of occurrence of the individual risks to human safety and efficiency during space flight to augment qualitative assessments used in this field to date. Quantitative probabilistic risk assessments will allow program managers to focus resources on those human health risks most likely to occur with undesirable consequences. Truly quantitative assessments are common, even expected, in the engineering and actuarial spheres, but that capability is just emerging in some arenas of life sciences research, such as identifying and minimize the hazards to astronauts during future space exploration missions. Our expectation is that these results can be used to inform NASA mission design trade studies in the near future with the objective of preventing the higher among the human health risks. We identify and discuss statistical techniques to provide this risk quantification based on relevant sets of astronaut biomedical data from short and long duration space flights as well as relevant analog populations. We outline critical assumptions made in the calculations and discuss the rationale for these. Our efforts to date have focussed on quantifying the probabilities of medical risks that are qualitatively perceived as relatively high risks of radiation sickness, cardiac dysrhythmias, medically significant renal stone formation due to increased calcium mobilization, decompression sickness as a result of EVA (extravehicular activity), and bone fracture due to loss of bone mineral density. We present these quantitative probabilities in order-of-magnitude comparison format so that relative risk can be gauged. We address the effects of conservative and nonconservative assumptions on the probability results. We discuss the methods necessary to assess mission risks once exploration mission scenarios are characterized. Preliminary efforts have produced results that are commensurate with earlier qualitative estimates of risk probabilities in this and other operational contexts, indicating that our approach may be usefully applied in support of the development of human health and performance standards for long-duration space exploration missions. This approach will also enable mission-specific probabilistic risk assessments for space exploration missions.

Bioastronautics: optimizing human performance through research and medical innovations

NASA Technical Reports Server (NTRS)

Williams, David R.

2002-01-01

A strategic use of resources is essential to achieving long-duration space travel and understanding the human physiological changes in space, including the roles of food and nutrition in space. To effectively address the challenges of space flight, the Bioastronautics Initiative, undertaken in 2001, expands extramural collaboration and leverages unique capabilities of the scientific community and the federal government, all the while applying this integrated knowledge to Earth-based problems. Integral to the National Aeronautics and Space Administration's missions in space is the reduction of risk of medical complications, particularly during missions of long duration. Cumulative medical experience and research provide the ability to develop evidence-based medicine for prevention, countermeasures, and treatment modalities for space flight. The early approach applied terrestrial clinical judgment to predict medical problems in space. Space medicine has evolved to an evidence-based approach with the use of biomedical data gathered and lessons learned from previous space flight missions to systematically aid in decision making. This approach led, for example, to the determination of preliminary nutritional requirements for space flight, and it aids in the development of nutrition itself as a countermeasure to support nutritional mitigation of adaptation to space.

Synthetic Biology and Human Health: Potential Applications for Spaceflight

NASA Technical Reports Server (NTRS)

Karouia, Fathi; Carr, Christopher; Cai, Yizhi; Chen, Y.; Grenon, Marlene; Larios-Sanz, Maia; Jones, Jeffrey A.; Santos, Orlando

2011-01-01

Human space travelers experience a unique environment that affects homeostasis and physiologic adaptation. Spaceflight-related changes have been reported in the musculo-skeletal, cardiovascular, neurovestibular, endocrine, and immune systems. The spacecraft environment further subjects the traveler to noise and gravitational forces, as well as airborne chemical, microbiological contaminants, and radiation exposure. As humans prepare for longer duration missions effective countermeasures must be developed, verified, and implemented to ensure mission success. Over the past ten years, synthetic biology has opened new avenues for research and development in areas such as biological control, biomaterials, sustainable energy production, bioremediation, and biomedical therapies. The latter in particular is of great interest to the implementation of long-duration human spaceflight capabilities. This article discusses the effects of spaceflight on humans, and reviews current capabilities and potential needs associated with the health of the astronauts where synthetic biology could play an important role in the pursuit of space exploration.

Habitability and Human Factors: Lessons Learned in Long Duration Space Flight

NASA Technical Reports Server (NTRS)

Baggerman, Susan D.; Rando, Cynthia M.; Duvall, Laura E.

2006-01-01

This study documents the investigation of qualitative habitability and human factors feedback provided by scientists, engineers, and crewmembers on lessons learned from the ISS Program. A thorough review and understanding of this data is critical in charting NASA's future path in space exploration. NASA has been involved in ensuring that the needs of crewmembers to live and work safely and effectively in space have been met throughout the ISS Program. Human factors and habitability data has been collected from every U.S. crewmember that has resided on the ISS. The knowledge gained from both the developers and inhabitants of the ISS have provided a significant resource of information for NASA and will be used in future space exploration. The recurring issues have been tracked and documented; the top 5 most critical issues have been identified from this data. The top 5 identified problems were: excessive onsrbit stowage; environment; communication; procedures; and inadequate design of systems and equipment. Lessons learned from these issues will be used to aid in future improvements and developments to the space program. Full analysis of the habitability and human factors data has led to the following recommendations. It is critical for human factors to be involved early in the design of space vehicles and hardware. Human factors requirements need to be readdressed and redefined given the knowledge gained during previous ISS and long-duration space flight programs. These requirements must be integrated into vehicle and hardware technical documentation and consistently enforced. Lastly, space vehicles and hardware must be designed with primary focus on the user/operator to successfully complete missions and maintain a safe working environment. Implementation of these lessons learned will significantly improve NASA's likelihood of success in future space endeavors.

ISS utilization and countermeasure validation: Implementing the critical path roadmap to reduce uncertainties of extended human spaceflight expeditions

NASA Astrophysics Data System (ADS)

Leveton, Lauren B.; Robinson, Judith L.; Charles, John B.

2000-01-01

Human exploration of space requires the ability to understand and mitigate risks to crews exposed to the conditions associated with such missions. This becomes a greater imperative as we prepare for interplanetary expeditions involving humans who will be subjected to long transit periods in microgravity as they travel to a distant planet such as Mars, embark and live on the planet's surface for an extended time, and finally, return to the 1 g environment of Earth. We need to know, more definitively, what the human health, safety, and performance risks are, and how to prevent or counteract them throughout all phases of a long duration mission. The Johnson Space Center's Space and Life Sciences Directorate along with the National Space Biomedical Research Institute (NSBRI) have been engaged in a strategic planning effort that identifies the most critical risks confronting humans who will venture forth on such missions and the types of research and technology efforts required to mitigate and otherwise reduce the probability and/or severity of those risks. This paper describes the unique approach used to define, assess and prioritize the risks and presents the results of the assessment with an emphasis on the research and technology priorities that will help us to meet the challenge of long duration human spaceflight missions. .

ISS Utilization and Countermeasure Validation: Implementing the Critical Path Roadmap to Reduce Uncertainties of Extended Human Spaceflight Expeditions

NASA Technical Reports Server (NTRS)

Leveton, Lauren B.; Robinson, Judith L.; Charles, John B.

2000-01-01

Human exploration of space requires the ability to understand and mitigate risks to crews exposed to the conditions associated with such missions. This becomes a greater imperative as we prepare for interplanetary expeditions involving humans who will be subjected to long transit periods in microgravity as they travel to a distant planet such as Mars, embark and live on the planet's surface for an extended time, and finally, return to the 1 g environment of Earth. We need to know, more definitively, what the human health, safety, and performance risks are, and how to prevent or counteract them throughout all phases of a long duration mission. The Johnson Space Center's Space and Life Sciences Directorate along with the National Space Biomedical Research Institute (NSBRI) have been engaged in a strategic planning effort that identifies the most critical risks confronting humans who will venture forth on such missions and the types of research and technology efforts required to mitigate and otherwise reduce the probability and/or severity of those risks. This paper describes the unique approach used to define, assess and prioritize the risks and presents the results of the assessment with an emphasis on the research and technology priorities that will help us to meet the challenge of long duration human spaceflight missions.

Living aloft: Human requirements for extended spaceflight

NASA Technical Reports Server (NTRS)

Connors, M. M.; Harrison, A. A.; Akins, F. R.

1985-01-01

Human psychological and social adjustment to space is investigated. Studies and experiences bearing on human performance capability, psychological well being, and social organization, as they relate to space, were identified and assessed, and suggestions offered as to where further research could ease the Earth/space transition. Special emphasis was given to the variables of crew size, crew diversity, and mission duration, all of which can be expected to increase in future spaceflight. By providing a conceptual framework in which issues and related information can be integrated, the hope is to aid in discovering those conditions under which future space travelers can flourish.

NASA Advanced Exploration Systems: Advancements in Life Support Systems

NASA Technical Reports Server (NTRS)

Shull, Sarah A.; Schneider, Walter F.

2016-01-01

The NASA Advanced Exploration Systems (AES) Life Support Systems (LSS) project strives to develop reliable, energy-efficient, and low-mass spacecraft systems to provide environmental control and life support systems (ECLSS) critical to enabling long duration human missions beyond low Earth orbit (LEO). Highly reliable, closed-loop life support systems are among the capabilities required for the longer duration human space exploration missions assessed by NASA’s Habitability Architecture Team.

Heavy Ion Carcinogenesis and Human Space Exploration

NASA Technical Reports Server (NTRS)

Cucinotta, Francis A.; Durante, Marco

2008-01-01

Prior to the human exploration of Mars or long duration stays on the Earth s moon, the risk of cancer and other diseases from space radiation must be accurately estimated and mitigated. Space radiation, comprised of energetic protons and heavy nuclei, has been show to produce distinct biological damage compared to radiation on Earth, leading to large uncertainties in the projection of cancer and other health risks, while obscuring evaluation of the effectiveness of possible countermeasures. Here, we describe how research in cancer radiobiology can support human missions to Mars and other planets.

Architectural considerations for lunar long duration habitat

NASA Astrophysics Data System (ADS)

Bahrami, Payam

The future of space exploration science and technology is expected to move toward long duration missions. During this long duration missions the most important factor to success will be the habitation system, the place that crew will live and work. The broad range of future space exploration, new advances in technology and increasing demand for space travel and space tourism will create great opportunities for architects to use their special abilities and skills in the realm of space. The lunar habitat is defined as a multidisciplinary task and cannot be considered an independent project from the main module. Therefore, habitability will become the most important aspect of future human exploration. A successful design strategy should integrate architecture, structure and other disciplines and should bring in elements such as psychological and physiological factors, human interfaces, and privacy. The current research provides "Habitat Architectural Design System (HADS)" in order to evaluate lunar habitat concepts based on habitability, functional optimization, and human factors. HADS helps to promote parametric studied and evaluation of habitat concepts. It will provide a guideline dependent upon mission objectives to standardize architectural needs within the engineering applications and scientific demands. The significance of this research is the process of developing lunar habitat concepts using an architectural system to evaluate the quality of each concept via habitability aspects. This process can be employed during the early stage of design development and is flexible enough to be adjusted by different parameters according to the objectives of lunar mission, limitations, and cost. It also emphasizes the importance of architecture involvement in space projects, especially habitats.

Long-Duration Space Flight

NASA Technical Reports Server (NTRS)

1997-01-01

Session WA1 includes short reports concerning: (1) Medical and Physiological Studies During 438-Day Space Flights: (2) Human Performance During a 14 Month Space Mission: (3) Homeostasis in Long-Term Microgravity Conditions; (4) Strategy of Preservation of Health of Cosmonauts in Prolonged and Superprolonged Space Flights; (5) Rehabilitation of Cosmonauts Health Following Long-Term Space Missions; and (6) Perfect Cosmonauts: Some Features of Bio-Portrait.

The Importance of Conducting Life Sciences Experiments on the Deep Space Gateway Platform

NASA Technical Reports Server (NTRS)

Bhattacharya, S.

2018-01-01

Over the last several decades important information has been gathered by conducting life science experiments on the Space Shuttle and on the International Space Station. It is now time to leverage that scientific knowledge, as well as aspects of the hardware that have been developed to support the biological model systems, to NASA's next frontier - the Deep Space Gateway. In order to facilitate long duration deep space exploration for humans, it is critical for NASA to understand the effects of long duration, low dose, deep space radiation on biological systems. While carefully controlled ground experiments on Earth-based radiation facilities have provided valuable preliminary information, we still have a significant knowledge gap on the biological responses of organisms to chronic low doses of the highly ionizing particles encountered beyond low Earth orbit. Furthermore, the combined effects of altered gravity and radiation have the potential to cause greater biological changes than either of these parameters alone. Therefore a thorough investigation of the biological effects of a cis-lunar environment will facilitate long term human exploration of deep space.

Space Medicine: A Surgeon's Perspective

NASA Technical Reports Server (NTRS)

Dawson, David L.

1999-01-01

For the first four decades of human space flight NASA's priorities in life sciences and medical programs have been preventative medicine (astronaut selection and training); assessment of the physiologic effects of microgravity and other unique aspects of space flight, implementation of countermeasures to protect against adverse effects, and amelioration of these adverse effects. Because most of the U.S. space flight experience has been on short duration missions, the need for medical and diagnostic treatment capabilities have been limited.The first long-term crews will arrive on the International Space Station (ISS) in early 2000. This will usher in a new era, an era of sustained human presence in Low Earth Orbit. One of the principal purposes of the ISS program is to increase the knowledge of the effects of long duration space flight on humans, a pre-requisite to future exploration class missions beyond Low Earth Orbit (e.g., a return to the Moon or an exploration of Mars). Areas of particular interest include protection from radiation, muscle atrophy, bone loss, cardiovascular alterations, immune dysfunction, adverse psychological response to hazards and confinement, and neurovestibular alterations. In addition, long duration space flight requires the development of autonomous medical care capabilities, as the distances involved eliminate the possibility of real-time telemedicine or robotic intervention, and prevent a mission abort and a rapid return to Earth. The objectives of this presentation include: 1. A description of the International Space Station project, including its research facilities and on-orbit medical capabilities; 2. An overview of the physiological and medical problems associated with microgravity in space flight; 3. A review of NASA's biomedical research priorities and ongoing work to develop clinical care capabilities for space flight crews (including surgical interventions) and; 4. An overview of current and proposed research priorities for NASA Research Announcements, NASA Space Biomedical Research Institute, Small Business Innovation Research Grant, and other funding sources.

The Critical Path Roadmap Project: Biomedical Risk Reduction for Extended Spaceflight

NASA Technical Reports Server (NTRS)

Charles, John B.; Leveton, Lauren B.

2000-01-01

Human exploration of space requires an understanding of the risks to which crews will be exposed during such missions, and the mitigation of those risks to the fullest extent practical. This becomes a greater imperative as we prepare for interplanetary expeditions involving long periods in weightlessness in transit to and then from the destination (a planet, such as Mars, or perhaps a point in space, such as the Lagrangian point L2), and exposure to the unique environment of the destination itself. We need to know, more definitively, what the risks are to human health, safety, and performance, and how to prevent or counteract them throughout all phases of a long duration mission. The Johnson Space Center's Space and Life Sciences Directorate and the National Space Biomedical Research Institute (NSBRI) have implemented an effort to identify the most critical risks confronting humans on such mission and the types of research and technology efforts required to mitigate and otherwise reduce the probability and severity of those risks. This paper describes the "Critical Path Roadmap Project" to define, assess and prioritize the risks and present the results of the assessment with an emphasis on the research and technology priorities to meet the challenge of long duration human spaceflight mission.

HAMLET -Human Model MATROSHKA for Radiation Exposure Determination of Astronauts -Current status and results

NASA Astrophysics Data System (ADS)

Reitz, Guenther; Berger, Thomas; Bilski, Pawel; Burmeister, Soenke; Labrenz, Johannes; Hager, Luke; Palfalvi, Jozsef K.; Hajek, Michael; Puchalska, Monika; Sihver, Lembit

The exploration of space as seen in specific projects from the European Space Agency (ESA) acts as groundwork for human long duration space missions. One of the main constraints for long duration human missions is radiation. The radiation load on astronauts and cosmonauts in space (as for the ISS) is a factor of 100 higher than the natural radiation on Earth and will further increase should humans travel to Mars. In preparation for long duration space missions it is important to evaluate the impact of space radiation in order to secure the safety of the astronauts and minimize their radiation risks. To determine the radiation risk on humans one has to measure the radiation doses to radiosensitive organs within the human body. One way to approach this is the ESA facility MATROSHKA (MTR), under the scientific and project lead of DLR. It is dedicated to determining the radiation load on astronauts within and outside the International Space Station (ISS), and was launched in January 2004. MTR is currently preparing for its fourth experimental phase inside the Japanese Experimental Module (JEM) in summer 2010. MTR, which mimics a human head and torso, is an anthropomorphic phantom containing over 6000 radiation detectors to determine the depth dose and organ dose distribution in the body. It is the largest international research initiative ever performed in the field of space dosimetry and combines the expertise of leading research institutions around the world, thereby generating a huge pool of data of potentially immense value for research. Aiming at optimal scientific exploitation, the FP7 project HAMLET aims to process and compile the data acquired individually by the participating laboratories of the MATROSHKA experiment. Based on experimental input from the MATROSHKA experiment phases as well as on radiation transport calculations, a three-dimensional model for the distribution of radiation dose in an astronaut's body will be built up. The scientific achievements contribute essentially to radiation risk estimations for future interplanetary space exploration by humans, putting them on a solid experimental and theoretical basis. The talk will give an overview of the current status of the MATROSHKA data evaluation and results and comparisons of the first three MTR experimental phases (MTR-1, 2A and 2B). The HAMLET project is funded by the European Commission under the EUs Seventh Frame-work Programme (FP7) under Project Nr: 218817 and coordinated by the German Aerospace Center (DLR) http://www-fp7-hamlet.eu

Planning strategies for development of effective exercise and nutrition countermeasures for long-duration space flight

NASA Technical Reports Server (NTRS)

Convertino, Victor A.

2002-01-01

Exercise and nutrition represent primary countermeasures used during space flight to maintain or restore maximal aerobic capacity, musculoskeletal structure, and orthostatic function. However, no single exercise, dietary regimen, or combination of prescriptions has proven entirely effective in maintaining or restoring cardiovascular and musculoskeletal functions to preflight levels after prolonged space flight. As human space flight exposures increase in duration, identification, assessment, and development of various effective exercise- and nutrition-based protective procedures will become paramount. The application of adequate dietary intake in combination with effective exercise prescription will be based on identification of basic physiologic stimuli that maintain normal function in terrestrial gravity, and understanding how specific combinations of exercise characteristics (e.g., duration, frequency, intensity, and mode) can be combined with minimal nutritional requirements that mimic the stimuli normally produced by living in Earth's gravity environment. This can be accomplished only with greater emphasis of research on ground-based experiments targeted at understanding the interactions between caloric intake and expenditure during space flight. Future strategies for application of nutrition and exercise countermeasures for long-duration space missions must be directed to minimizing crew time and the impact on life-support resources.

Planning strategies for development of effective exercise and nutrition countermeasures for long-duration space flight.

PubMed

Convertino, Victor A

2002-10-01

Exercise and nutrition represent primary countermeasures used during space flight to maintain or restore maximal aerobic capacity, musculoskeletal structure, and orthostatic function. However, no single exercise, dietary regimen, or combination of prescriptions has proven entirely effective in maintaining or restoring cardiovascular and musculoskeletal functions to preflight levels after prolonged space flight. As human space flight exposures increase in duration, identification, assessment, and development of various effective exercise- and nutrition-based protective procedures will become paramount. The application of adequate dietary intake in combination with effective exercise prescription will be based on identification of basic physiologic stimuli that maintain normal function in terrestrial gravity, and understanding how specific combinations of exercise characteristics (e.g., duration, frequency, intensity, and mode) can be combined with minimal nutritional requirements that mimic the stimuli normally produced by living in Earth's gravity environment. This can be accomplished only with greater emphasis of research on ground-based experiments targeted at understanding the interactions between caloric intake and expenditure during space flight. Future strategies for application of nutrition and exercise countermeasures for long-duration space missions must be directed to minimizing crew time and the impact on life-support resources.

Nutritional models for a Controlled Ecological Life Support System (CELSS): Linear mathematical modeling

NASA Technical Reports Server (NTRS)

Wade, Rose C.

1989-01-01

The NASA Controlled Ecological Life Support System (CELSS) Program is involved in developing a biogenerative life support system that will supply food, air, and water to space crews on long-duration missions. An important part of this effort is in development of the knowledge and technological capability of producing and processing foods to provide optimal diets for space crews. This involves such interrelated factors as determination of the diet, based on knowledge of nutrient needs of humans and adjustments in those needs that may be required as a result of the conditions of long-duration space flight; determination of the optimal mixture of crops required to provide nutrients at levels that are sufficient but not excessive or toxic; and consideration of the critical issues of spacecraft space and power limitations, which impose a phytomass minimization requirement. The complex interactions among these factors are examined with the goal of supplying a diet that will satisfy human needs while minimizing the total phytomass requirement. The approach taken was to collect plant nutritional composition and phytomass production data, identify human nutritional needs and estimate the adjustments to the nutrient requirements likely to result from space flight, and then to generate mathematical models from these data.

Relativistic compression and expansion of experiential time in the left and right space.

PubMed

Vicario, Carmelo Mario; Pecoraro, Patrizia; Turriziani, Patrizia; Koch, Giacomo; Caltagirone, Carlo; Oliveri, Massimiliano

2008-03-05

Time, space and numbers are closely linked in the physical world. However, the relativistic-like effects on time perception of spatial and magnitude factors remain poorly investigated. Here we wanted to investigate whether duration judgments of digit visual stimuli are biased depending on the side of space where the stimuli are presented and on the magnitude of the stimulus itself. Different groups of healthy subjects performed duration judgment tasks on various types of visual stimuli. In the first two experiments visual stimuli were constituted by digit pairs (1 and 9), presented in the centre of the screen or in the right and left space. In a third experiment visual stimuli were constituted by black circles. The duration of the reference stimulus was fixed at 300 ms. Subjects had to indicate the relative duration of the test stimulus compared with the reference one. The main results showed that, regardless of digit magnitude, duration of stimuli presented in the left hemispace is underestimated and that of stimuli presented in the right hemispace is overestimated. On the other hand, in midline position, duration judgments are affected by the numerical magnitude of the presented stimulus, with time underestimation of stimuli of low magnitude and time overestimation of stimuli of high magnitude. These results argue for the presence of strict interactions between space, time and magnitude representation on the human brain.

On-Line Analysis of Physiologic and Neurobehavioral Variables During Long-Duration Space Missions

NASA Technical Reports Server (NTRS)

Brown, Emery N.

1999-01-01

The goal of this project is to develop reliable statistical algorithms for on-line analysis of physiologic and neurobehavioral variables monitored during long-duration space missions. Maintenance of physiologic and neurobehavioral homeostasis during long-duration space missions is crucial for ensuring optimal crew performance. If countermeasures are not applied, alterations in homeostasis will occur in nearly all-physiologic systems. During such missions data from most of these systems will be either continually and/or continuously monitored. Therefore, if these data can be analyzed as they are acquired and the status of these systems can be continually assessed, then once alterations are detected, appropriate countermeasures can be applied to correct them. One of the most important physiologic systems in which to maintain homeostasis during long-duration missions is the circadian system. To detect and treat alterations in circadian physiology during long duration space missions requires development of: 1) a ground-based protocol to assess the status of the circadian system under the light-dark environment in which crews in space will typically work; and 2) appropriate statistical methods to make this assessment. The protocol in Project 1, Circadian Entrainment, Sleep-Wake Regulation and Neurobehavioral will study human volunteers under the simulated light-dark environment of long-duration space missions. Therefore, we propose to develop statistical models to characterize in near real time circadian and neurobehavioral physiology under these conditions. The specific aims of this project are to test the hypotheses that: 1) Dynamic statistical methods based on the Kronauer model of the human circadian system can be developed to estimate circadian phase, period, amplitude from core-temperature data collected under simulated light- dark conditions of long-duration space missions. 2) Analytic formulae and numerical algorithms can be developed to compute the error in the estimates of circadian phase, period and amplitude determined from the data in Specific Aim 1. 3) Statistical models can detect reliably in near real- time (daily) significant alternations in the circadian physiology of individual subjects by analyzing the circadian and neurobehavioral data collected in Project 1. 4) Criteria can be developed using the Kronauer model and the recently developed Jewett model of cognitive -performance and subjective alertness to define altered circadian and neurobehavioral physiology and to set conditions for immediate administration of countermeasures.

Human factors research as part of a Mars exploration analogue mission on Devon Island

NASA Astrophysics Data System (ADS)

Binsted, Kim; Kobrick, Ryan L.; Griofa, Marc Ó.; Bishop, Sheryl; Lapierre, Judith

2010-06-01

Human factors research is a critical element of space exploration as it provides insight into a crew's performance, psychology and interpersonal relationships. Understanding the way humans work in space-exploration analogue environments permits the development and testing of countermeasures for and responses to potential hazardous situations, and can thus help improve mission efficiency and safety. Analogue missions, such as the one described here, have plausible mission constraints and operational scenarios, similar to those that a real Mars crew would experience. Long duration analogue studies, such as those being conducted at the Flashline Mars Arctic Research Station (FMARS) on Devon Island, Canada, offer an opportunity to study mission operations and human factors in a semi-realistic environment, and contribute to the design of missions to explore the Moon and Mars. The FMARS XI Long Duration Mission (F-XI LDM) was, at four months, the longest designed analogue Mars mission conducted to date, and thus provides a unique insight into human factors issues for long-duration space exploration. Here, we describe the six human factors studies that took place during F-XI LDM, and give a summary of their results, where available. We also present a meta-study, which examined the impact of the human-factors research itself on crew schedule and workload. Based on this experience, we offer some lessons learnt: some aspects (perceived risk and crew motivation, for example) of analogue missions must be realistic for study results to be valid; human factors studies are time-consuming, and should be fully integrated into crew schedules; and crew-ground communication and collaboration under long-term exploration conditions can present serious challenges.

Building a Shared Definitional Model of Long Duration Human Spaceflight

NASA Technical Reports Server (NTRS)

Orr, M.; Whitmire, A.; Sandoval, L.; Leveton, L.; Arias, D.

2011-01-01

In 1956, on the eve of human space travel Strughold first proposed a simple classification of the present and future stages of manned flight that identified key factors, risks and developmental stages for the evolutionary journey ahead. As we look to optimize the potential of the ISS as a gateway to new destinations, we need a current shared working definitional model of long duration human space flight to help guide our path. Initial search of formal and grey literature augmented by liaison with subject matter experts. Search strategy focused on both the use of term long duration mission and long duration spaceflight, and also broader related current and historical definitions and classification models of spaceflight. The related sea and air travel literature was also subsequently explored with a view to identifying analogous models or classification systems. There are multiple different definitions and classification systems for spaceflight including phase and type of mission, craft and payload and related risk management models. However the frequently used concepts of long duration mission and long duration spaceflight are infrequently operationally defined by authors, and no commonly referenced classical or gold standard definition or model of these terms emerged from the search. The categorization (Cat) system for sailing was found to be of potential analogous utility, with its focus on understanding the need for crew and craft autonomy at various levels of potential adversity and inability to gain outside support or return to a safe location, due to factors of time, distance and location.

Policy issues in space analogues

NASA Astrophysics Data System (ADS)

Auger, Robin N.; Facktor, Debra D.

Space mission planning is increasingly focusing on destinations beyond Earth orbit. Advancements in technology will inevitably be required to enable long-duration human spaceflight missions, and breakthroughs in the policy arena will also be needed to achieve success in such missions. By exploring how policy issues have been addressed in analogous extreme environments, policymakers can develop a framework for addressing these issues as they apply to long-term human spaceflight. Policy issues that need to be addressed include: crew selection, training, organization, and activities, medical testing, illness, injury, and death; communication; legal accountability and liability; mission safety and risk management; and environmental contamination. This paper outlines the approach of a study underway by The George Washington University and ANSER to examine how these policy issues have been addressed in several analogues and how the experiences of these analogues can help formulate policies for long-duration human spaceflight missions. Analogues being studied include Antarctic bases, submarine voyages, undersea stations, Biosphere 2, and the U.S. Skylab and Russian Mir space stations.

Changes in the central nervous system during long-duration space flight: implications for neuro-imaging

NASA Astrophysics Data System (ADS)

Newberg, A. B.; Alavi, A.

The purpose of this paper is to review the potential functional and morphological effects of long duration space flight on the human central nervous system (CNS) and how current neuroimaging techniques may be utilized to study these effects. It must be determined if there will be any detrimental changes to the CNS from long term exposure to the space environment if human beings are to plan interplanetary missions or establish permanent space habitats. Research to date has focused primarily on the short term changes in the CNS as the result of space flight. The space environment has many factors such as weightlessness, electromagnetic fields, and radiation, that may impact upon the function and structure of the CNS. CNS changes known to occur during and after long term space flight include neurovestibular disturbances, cephalic fluid shifts, alterations in sensory perception, changes in proprioception, psychological disturbances, and cognitive changes. Animal studies have shown altered plasticity of the neural cytoarchitecture, decreased neuronal metabolism in the hypothalamus, and changes in neurotransmitter concentrations. Recent progress in the ability to study brain morphology, cerebral metabolism, and neurochemistry in vivo in the human brain would provide ample opportunity to investigate many of the changes that occur in the CNS as a result of space flight. These methods include positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI).

Research Objectives for Human Missions in the Proving Ground of Cis-Lunar Space

NASA Astrophysics Data System (ADS)

Spann, James; Niles, Paul; Eppler, Dean; Kennedy, Kriss; Lewis, Ruthan; Sullivan, Thomas

2016-07-01

Introduction: This talk will introduce the preliminary findings in support of NASA's Future Capabilities Team. In support of the ongoing studies conducted by NASA's Future Capabilities Team, we are tasked with collecting re-search objectives for the Proving Ground activities. The objectives could include but are certainly not limited to: demonstrating crew well being and performance over long duration missions, characterizing lunar volatiles, Earth monitoring, near Earth object search and identification, support of a far-side radio telescope, and measuring impact of deep space environment on biological systems. Beginning in as early as 2023, crewed missions beyond low Earth orbit will be enabled by the new capabilities of the SLS and Orion vehicles. This will initiate the "Proving Ground" phase of human exploration with Mars as an ultimate destination. The primary goal of the Proving Ground is to demonstrate the capability of suitably long dura-tion spaceflight without need of continuous support from Earth, i.e. become Earth Independent. A major component of the Proving Ground phase is to conduct research activities aimed at accomplishing major objectives selected from a wide variety of disciplines including but not limited to: Astronomy, Heliophysics, Fun-damental Physics, Planetary Science, Earth Science, Human Systems, Fundamental Space Biology, Microgravity, and In Situ Resource Utilization. Mapping and prioritizing the most important objectives from these disciplines will provide a strong foundation for establishing the architecture to be utilized in the Proving Ground. Possible Architectures: Activities and objectives will be accomplished during the Proving Ground phase using a deep space habitat. This habitat will potentially be accompanied by a power/propulsion bus capable of moving the habitat to accomplish different objectives within cis-lunar space. This architecture can also potentially support stag-ing of robotic and tele-robotic assets as well as sample-return. As mission durations increase from 20 days to 300 days, increasingly ambitious objectives may be undertaken in-cluding rendezvous with an asteroid or other near-Earth object. Research activities can occur inside the habitat, outside the habitat, via externally mounted instruments, or using free flying satellites/landers. Research Objectives: Primary mission objectives are listed below. In order to help define details of the mission architecture, including the means by which the architecture can be supported, more specific research objectives are needed. Title/Objective • Crew Transportation/Provide ability to transport at least four crew to cislunar space • Heavy Launch Capability/Provide beyond-LEO launch capabilities to include crew, co-manisfested pay-loads, and large cargo • In-Space Propulsion/Provide in-space propulsion capabilities to send crew and cargo on Mars-class mission durations and distances • Deep Space Navigation and Communication/Provide and validate cislunar and Mars system navigation and communication • Science/Enable science community objectives • Deep Space Operations/Provide deep-space operation capabilities: EVA, Staging, Logistics, Human-robotic integration, Autonomous operations • In-Situ Resource Utilization/Understand the nature and distribution of volatiles and extraction techniques, and decide on their potential use in the human exploration architecture • Deep Space Habitation/Provide beyond-LEO habitation systems sufficient to support at least four crew on Mars-class mission durations and dormancy • Crew Health/Validate crew health, performance, and mitigation protocols for Mars-class missions Reference: NASA, NASA's Journey to Mars: Pioneering Next Steps in Space Exploration. 34 ( October 8, 2015).

A new conceptual design approach for habitative space modules

NASA Astrophysics Data System (ADS)

Burattini, C.; Bisegna, F.; Gugliermetti, F.; Marchetti, M.

2014-04-01

Existing Space modules were designed to meet the standards established by NASA, basically oriented to functionality. In future Space environments a high level of habitability in long duration missions will become a priority: besides comfort and ergonomics, these habitats will require the application of criteria to address human needs for living in confined environments.

Physiology, medicine, long-duration space flight and the NSBRI

NASA Technical Reports Server (NTRS)

McPhee, J. C.; White, R. J.

2003-01-01

The hazards of long-duration space flight are real and unacceptable. In order for humans to participate effectively in long-duration orbital missions or continue the exploration of space, we must first secure the health of the astronaut and the success of such missions by assessing in detail the biomedical risks of space flight and developing countermeasures to these hazards. Acquiring the understanding necessary for building a sound foundation for countermeasure development requires an integrated approach to research in physiology and medicine and a level of cooperative action uncommon in the biomedical sciences. The research program of the National Space Biomedical Research Institute (NSBRI) was designed to accomplish just such an integrated research goal, ameliorating or eliminating the biomedical risks of long-duration space flight and enabling safe and productive exploration of space. The fruits of these labors are not limited to the space program. We can also use the gained understanding of the effects and mechanisms of the physiological changes engendered in space and the applied preventive and rehabilitative methods developed to combat these changes to the benefit of those on Earth who are facing similar physiological and psychological difficulties. This paper will discuss the innovative approach the NSBRI has taken to integrated research management and will present some of the successes of this approach. c2003 International Astronautical Federation. Published by Elsevier Science Ltd. All rights reserved.

Atmosphere Selection for Long-duration Manned Space Missions

NASA Technical Reports Server (NTRS)

Hirsch, David B.

2007-01-01

This viewgraph reviews the spacecraft environment for future human space exploration missions. The choice of a atmosphere mix will play a critical role in the ultimate safety, productivity, and cost. There are a multitude of factors involved in selection of spacecraft environments.

Architecting Systems for Human Space Flight

NASA Technical Reports Server (NTRS)

Wocken, Gerald

2002-01-01

Human-system interactions have been largely overlooked in the traditional systems engineering process. Awareness of human factors (HF) has increased in the past few years, but the involvement of HF specialists is still often too little and too late. In systems involving long-duration human space flight, it is essential that the human component be properly considered in the initial architectural definition phase, as well as throughout the system design process. HF analysis must include not only the strengths and limitations of humans in general, but the variability between individuals and within an individual over time, and the dynamics of group interactions.

A Mission Concept Based on the ISECG Human Lunar Surface Architecture

NASA Technical Reports Server (NTRS)

Gruener, J. E.; Lawrence, S. J.

2017-01-01

The National Aeronautics and Space Administration (NASA) is participating in the International Space Exploration Coordination Group (ISECG), working together with 13 other space agencies to advance a long-range human space exploration strategy. The ISECG has developed a Global Exploration Roadmap (GER) that reflects the coordinated international dialog and continued preparation for exploration beyond low-Earth orbit - beginning with the International Space Station (ISS) and continuing to the Moon, near-Earth asteroids, and Mars [1]. The roadmap demonstrates how initial capabilities can enable a variety of missions in the lunar vicinity, responding to individual and common goals and objectives, while contributing to building partnerships required for sustainable human space exploration that delivers value to the public. The current GER includes three different near-term themes: exploration of a near-Earth asteroid, extended duration crew missions in cis-lunar space, and humans to the lunar surface.

Identification of Psychological Stresses for Astronauts and Cosmonauts

NASA Astrophysics Data System (ADS)

Marsh, Melinda

As humans continue to explore and expand in the solar system, psychological problems brought about by high stress of living in the space environment will continue to increase. Unfortunately, due to many reasons, including relative difficulties with gaining access to astronauts and cosmonauts and to gather psychological data from them regarding stressors, this area is not very well known and discussed. Five astronauts and cosmonauts from three space agencies: ESA, RSA, and JAXA were unoffi- cially surveyed regarding their experiences with ten general categories of psychological stressors as well as eight subcategories of interpersonal conflict stressors accepted in space related community of psychologists. The two subjects in space for longer periods of time reported more stressors and were likely to rate stressors as having a greater effect on the chance of mission failure. Shorter duration flyers reported nearly all general stressors were likely to increase in the event of a longer duration space flight. With the increased interest in long duration spaceflight, psychological stressors are more likely to affect mission success.

Prototype Aerogel Insulation for Melamine-Foam Substitute: Critical Space Station Express Rack Technology

NASA Technical Reports Server (NTRS)

Noever, David A.; Sibille, Laurent; Smith, David; Cronise, Raymond

1998-01-01

There is a current lack of environmentally acceptable foams to insulate Long-Duration Human Spaceflight Missions, including the experimental Express Rack for the Space Station. A recent 60-day manned test in a sealed chamber at Johnson Space Center (JSC) was nearly aborted, because of persistently high formaldehyde concentrations in the chamber. Subsequent investigation showed that the source was melamine foam (used extensively for acoustic insulation). The thermal and acoustic potential for melamine-foam substitutes is evaluated for scale-up to a silica-based foam and aerogel, which is environmentally benign for long duration space flight. These features will be discussed in reference to an aerogel prototype to: 1) assemble material strength data for various formulated aerogels, both silica and organic carbon aerogels; 2) assemble the aerogel into panels of mylar/vacuum-encapsulated rigid boards which can be molded in various shapes and rigidities; and 3) describe a process for space applications for formaldehyde-free, long duration thermal and acoustic insulators.

Developing a Habitat for Long Duration, Deep Space Missions

NASA Technical Reports Server (NTRS)

Rucker, Michelle A.; Thompson, Shelby

2011-01-01

One possible next leap in human space exploration is a mission to a near Earth asteroid (NEA). In order to achieve such an ambitious goal, a space habitat will need to be designed to accommodate a crew of four for the 380-day round trip. The Human Spaceflight Architecture Team (HAT) developed a conceptual design for such a habitat. The team identified activities that would be performed inside a long-duration, deep space habitat, and the capabilities needed to support such a mission. A list of seven functional activities/capabilities was developed: individual and group crew care, spacecraft and mission operations, subsystem equipment, logistics and resupply, and contingency operations. The volume for each activity was determined using NASA STD-3001 and the companion Human Integration Design Handbook (HIDH). Although, the sum of these volumes produced an over-sized spacecraft, the team evaluated activity frequency and duration to identify functions that could share a common volume without conflict, reducing the total volume by 24%. After adding 10% for growth, the resulting functional pressurized volume was calculated to be 268 m3 distributed over the functions. The work was validated through comparison with the International Space Station (ISS), Bigelow Aerospace s proposed habitat module, and NASA s Trans-Hab concepts. In the end, the team developed an internal layout that (a) minimized the transit time between related crew stations, (b) accommodated expected levels of activity at each station, (c) isolated stations when necessary for health, safety, performance, and privacy, and (d) provided a safe, efficient, and comfortable work and living environment.

Human Research Program Human Health Countermeasures Element: Evidence Report - Artificial Gravity

NASA Technical Reports Server (NTRS)

Clement, Gilles

2015-01-01

The most serious risks of long-duration flight involve radiation, behavioral stresses, and physiological deconditioning. Artificial gravity (AG), by substituting for the missing gravitational cues and loading in space, has the potential to mitigate the last of these risks by preventing the adaptive responses from occurring. The rotation of a Mars-bound spacecraft or an embarked human centrifuge offers significant promise as an effective, efficient multi-system countermeasure against the physiological deconditioning associated with prolonged weightlessness. Virtually all of the identified risks associated with bone loss, muscle weakening, cardiovascular deconditioning, and sensorimotor disturbances might be alleviated by the appropriate application of AG. However, experience with AG in space has been limited and a human-rated centrifuge is currently not available on board the ISS. A complete R&D program aimed at determining the requirements for gravity level, gravity gradient, rotation rate, frequency, and duration of AG exposure is warranted before making a decision for implementing AG in a human spacecraft.

Developing a Habitat for Long Duration, Deep Space Missions

NASA Technical Reports Server (NTRS)

Rucker, Michelle A.; Thompson, Shelby

2012-01-01

One possible next leap in human space exploration for the National Aeronautics and Space Administration (NASA) is a mission to a near Earth asteroid (NEA). In order to achieve such an ambitious goal, a space habitat will need to accommodate a crew of four for the 380-day round trip. The Human Spaceflight Architecture Team (HAT) developed a conceptual design for such a habitat. The team identified activities that would be performed inside a long-duration, deep space habitat, and the capabilities needed to support such a mission. A list of seven functional activities/capabilities was developed: individual and group crew care, spacecraft and mission operations, subsystem equipment, logistics and resupply, and contingency operations. The volume for each activity was determined using NASA STD-3001 and the companion Human Integration Design Handbook (HIDH). Although, the sum of these volumes produced an over-sized spacecraft, the team evaluated activity frequency and duration to identify functions that could share a common volume without conflict, reducing the total volume by 24%. After adding 10% for growth, the resulting functional pressurized volume was calculated to be a minimum of 268 cu m (9,464 cu ft) distributed over the functions. The work was validated through comparison to Mir, Skylab, the International Space Station (ISS), Bigelow Aerospace s proposed habitat module, and NASA s Trans-Hab concept. Using HIDH guidelines, the team developed an internal layout that (a) minimized the transit time between related crew stations, (b) accommodated expected levels of activity at each station, (c) isolated stations when necessary for health, safety, performance, and privacy, and (d) provided a safe, efficient, and comfortable work and living environment.

Research Objectives for Human Missions in the Proving Ground of Cis-Lunar Space

NASA Astrophysics Data System (ADS)

Spann, James; Niles, Paul B.; Eppler, Dean B.; Kennedy, Kriss J.; Lewis, Ruthan.; Sullivan, Thomas A.

2016-04-01

Introduction: This talk will introduce the preliminary findings in support of NASA's Future Capabilities Team. In support of the ongoing studies conducted by NASA's Future Capabilities Team, we are tasked with collecting research objectives for the Proving Ground activities. The objectives could include but are certainly not limited to: demonstrating crew well being and performance over long duration missions, characterizing lunar volatiles, Earth monitoring, near Earth object search and identification, support of a far-side radio telescope, and measuring impact of deep space environment on biological systems. Beginning in as early as 2023, crewed missions beyond low Earth orbit will begin enabled by the new capabilities of the SLS and Orion vehicles. This will initiate the "Proving Ground" phase of human exploration with Mars as an ultimate destination. The primary goal of the Proving Ground is to demonstrate the capability of suitably long duration spaceflight without need of continuous support from Earth, i.e. become Earth Independent. A major component of the Proving Ground phase is to conduct research activities aimed at accomplishing major objectives selected from a wide variety of disciplines including but not limited to: Astronomy, Heliophysics, Fundamental Physics, Planetary Science, Earth Science, Human Systems, Fundamental Space Biology, Microgravity, and In Situ Resource Utilization. Mapping and prioritizing the most important objectives from these disciplines will provide a strong foundation for establishing the architecture to be utilized in the Proving Ground. Possible Architectures: Activities and objectives will be accomplished during the Proving Ground phase using a deep space habitat. This habitat will potentially be accompanied by a power/propulsion bus capable of moving the habitat to accomplish different objectives within cis-lunar space. This architecture can also potentially support staging of robotic and tele-robotic assets as well as sample-return. As mission durations increase from 20 days to 300 days, increasingly ambitious objectives may be undertaken including rendezvous with an asteroid or other near-Earth object. Research activities can occur inside the habitat, outside the habitat, via externally mounted instruments, or using free flying satellites/landers. Research Objectives: Primary mission objectives are listed below. In order to help define details of the mission architecture, including the means by which the architecture can be supported, more specific research objectives are needed. Title/Objective Crew Transportation/Provide ability to transport at least four crew to cislunar space Heavy Launch Capability/Provide beyond LEO launch capabilities to include crew, co-manisfested payloads, and large cargo In-Space Propulsion/Provide in-sapce propulsion capabilities to send crew and cargo on Mars-class mission durations and distances Deep Space Navigation and Communication/Provide and validate cislunar and Mars system navigation and communication Science/Enable science community objectives Deep Space Operations/Provide deep-space operation capabilities: EVA, Staging, Logistics, Human-robotic integration, Autonomous operations In-Situ Resource Utilization/Understand the nature and distribution of volatiles and extraction techniques, and decide on their potential use in the human exploration architecture Deep Space Habitation/Provide beyond LEO habitation systems sufficient to support at least four crew on Mars-class mission durations and dormancy Crew Health/Validate crew health, performance, and mitigation protocols for Mars-class missions Reference: .NASA, NASA's Journey to Mars: Pioneering Next Steps in Space Exploration. 34 ( October 8, 2015).

Human factors issues for interstellar spacecraft

NASA Technical Reports Server (NTRS)

Cohen, Marc M.; Brody, Adam R.

1991-01-01

Developments in research on space human factors are reviewed in the context of a self-sustaining interstellar spacecraft based on the notion of traveling space settlements. Assumptions about interstellar travel are set forth addressing costs, mission durations, and the need for multigenerational space colonies. The model of human motivation by Maslow (1970) is examined and directly related to the design of space habitat architecture. Human-factors technology issues encompass the human-machine interface, crew selection and training, and the development of spaceship infrastructure during transtellar flight. A scenario for feasible instellar travel is based on a speed of 0.5c, a timeframe of about 100 yr, and an expandable multigenerational crew of about 100 members. Crew training is identified as a critical human-factors issue requiring the development of perceptual and cognitive aids such as expert systems and virtual reality.

The Near-Earth Object Human Space Flight Accessible Targets Study (NHATS) List of Near-Earth Asteroids: Identifying Potential Targets for Future Exploration

NASA Astrophysics Data System (ADS)

Abell, Paul; Barbee, B. W.; Mink, R. G.; Adamo, D. R.; Alberding, C. M.; Mazanek, D. D.; Johnson, L. N.; Yeomans, D. K.; Chodas, P. W.; Chamberlin, A. B.; Benner, L. A. M.; Drake, B. G.; Friedensen, V. P.

2012-10-01

Introduction: Much attention has recently been focused on human exploration of near-Earth asteroids (NEAs). Detailed planning for deep space exploration and identification of potential NEA targets for human space flight requires selecting objects from the growing list of known NEAs. NASA therefore initiated the Near-Earth Object Human Space Flight Accessible Target Study (NHATS), which uses dynamical trajectory performance constraints to identify potentially accessible NEAs. Accessibility Criteria: Future NASA human space flight capability is being defined while the Orion Multi-Purpose Crew Vehicle and Space Launch System are under development. Velocity change and mission duration are two of the most critical factors in any human spaceflight endeavor, so the most accessible NEAs tend to be those with orbits similar to Earth’s. To be classified as NHATS-compliant, a NEA must offer at least one round-trip trajectory solution satisfying purposely inclusive constraints, including total mission change in velocity ≤ 12 km/s, mission duration ≤ 450 days (with at least 8 days at the NEA), Earth departure between Jan 1, 2015 and Dec 31, 2040, Earth departure C3 ≤ 60 km2/s2, and Earth return atmospheric entry speed ≤ 12 km/s. Monitoring and Updates: The NHATS list of potentially accessible targets is continuously updated as NEAs are discovered and orbit solutions for known NEAs are improved. The current list of accessible NEAs identified as potentially viable for future human exploration under the NHATS criteria is available to the international community via a website maintained by NASA’s NEO Program Office (http://neo.jpl.nasa.gov/nhats/). This website also lists predicted optical and radar observing opportunities for each NHATS-compliant NEA to facilitate acquisition of follow-up observations. Conclusions: This list of NEAs will be useful for analyzing robotic mission opportunities, identifying optimal round trip human space flight trajectories, and highlighting attractive objects of interest for future ground-based observation opportunities.

Thermodynamic considerations in the support of life for long space voyages

NASA Technical Reports Server (NTRS)

Iberall, A. S.; Cardon, S. Z.

1979-01-01

The essential requirements for the maintenance of life, particularly human life, on isolated space missions of long duration were investigated through the study of extended irreversible thermodynamics. The characterization of a four trophic level system was developed. Questions of stability are discussed.

An assessment of waste processing/resource recovery technologies for lunar/Mars life applications

NASA Technical Reports Server (NTRS)

Verostko, Charles E.; Packham, Nigel J. C.; Henninger, Donald H.

1992-01-01

NASA's future manned missions to explore the solar system are by nature of long duration, mandating extensive regeneration of life support consumables from wastes generated in space-based habitats. Long-duration exploration missions would otherwise be prohibitive due to the number and frequency of energy-intensive resupply missions from Earth. Resource recovery is therefore a critical component of the controlled ecological life support system (CELSS). In order to assess resource recovery technologies for CELSS applications, the Crew and Thermal Systems Division at NASA-Johnson Space Center convened a three-day workshop to assess potential resource recovery technologies for application in a space-based CELSS. This paper describes the methodology of assessing and ranking of these technologies. Recommendations and issues are identified. Evaluations focused on the processes for handling and treatment of inedible plant biomass, human waste, and human generated trash. Technologies were assessed on the basis of safety, reliability, technology readiness, and performance characteristics.

Human Performance in Space

NASA Technical Reports Server (NTRS)

Jones, Patricia M.; Fiedler, Edna

2010-01-01

Human factors is a critical discipline for human spaceflight. Nearly every human factors research area is relevant to space exploration -- from the ergonomics of hand tools used by astronauts, to the displays and controls of a spacecraft cockpit or mission control workstation, to levels of automation designed into rovers on Mars, to organizational issues of communication between crew and ground. This chapter focuses more on the ways in which the space environment (especially altered gravity and the isolated and confined nature of long-duration spaceflight) affects crew performance, and thus has specific novel implications for human factors research and practice. We focus on four aspects of human performance: neurovestibular integration, motor control and musculo-skeletal effects, cognitive effects, and behavioral health. We also provide a sampler of recent human factors studies from NASA.

Fundamentals of Space Medicine

NASA Astrophysics Data System (ADS)

Clément, Gilles

2005-03-01

A total of more than 240 human space flights have been completed to date, involving about 450 astronauts from various countries, for a combined total presence in space of more than 70 years. The seventh long-duration expedition crew is currently in residence aboard the International Space Station, continuing a permanent presence in space that began in October 2000. During that time, investigations have been conducted on both humans and animal models to study the bone demineralization and muscle deconditioning, space motion sickness, the causes and possible treatment of postflight orthostatic intolerance, the changes in immune function, crew and crew-ground interactions, and the medical issues of living in a space environment, such as the effects of radiation or the risk of developing kidney stones. Some results of these investigations have led to fundamental discoveries about the adaptation of the human body to the space environment. Gilles Clément has been active in this research. This readable text presents the findings from the life science experiments conducted during and after space missions. Topics discussed in this book include: adaptation of sensory-motor, cardio-vascular, bone, and muscle systems to the microgravity of spaceflight; psychological and sociological issues of living in a confined, isolated, and stressful environment; operational space medicine, such as crew selection, training and in-flight health monitoring, countermeasures and support; results of space biology experiments on individual cells, plants, and animal models; and the impact of long-duration missions such as the human mission to Mars. The author also provides a detailed description of how to fly a space experiment, based on his own experience with research projects conducted onboard Salyut-7, Mir, Spacelab, and the Space Shuttle. Now is the time to look at the future of human spaceflight and what comes next. The future human exploration of Mars captures the imagination of both the public and the scientific community. Many physiological, psychological, operational, and scientific issues need to be solved before the first crew can explore the enigmatic Red Planet. This book also identifies the showstoppers that can be foreseen and what we need to learn to fully understand the implications and risks of such a mission.

Human behavioral research in space: quandaries for research subjects and researchers

NASA Technical Reports Server (NTRS)

Shepanek, Marc

2005-01-01

With the advent of long-duration spaceflight on board the International Space Station (ISS) and possible future missions beyond low Earth orbit (LEO) such as Mars, it is critical that those at NASA have a realistic assessment of the challenges that will face individuals on long-duration missions so that they can develop preventive and real-time countermeasures to behavioral health issues. While space travellers are very interested in having countermeasures to the deleterious effects of space missions, they have a powerful disincentive to participate in this research if they feel it could in any way negatively affect their flight status. The behavioral issues of isolation and confinement for extended-duration space missions are reviewed. Areas of basic and clinical behavioral research are listed. And the classical clinical model for research is not considered appropriate for the current configuration of the space program. The use of analogue environments and advanced statistical analysis are suggested as ways to address the limited spaceflight research opportunities. The challenge of research subject or patient confidentiality vs. mission safety and issues of personal flight status are addressed.

Human behavioral research in space: quandaries for research subjects and researchers.

PubMed

Shepanek, Marc

2005-06-01

With the advent of long-duration spaceflight on board the International Space Station (ISS) and possible future missions beyond low Earth orbit (LEO) such as Mars, it is critical that those at NASA have a realistic assessment of the challenges that will face individuals on long-duration missions so that they can develop preventive and real-time countermeasures to behavioral health issues. While space travellers are very interested in having countermeasures to the deleterious effects of space missions, they have a powerful disincentive to participate in this research if they feel it could in any way negatively affect their flight status. The behavioral issues of isolation and confinement for extended-duration space missions are reviewed. Areas of basic and clinical behavioral research are listed. And the classical clinical model for research is not considered appropriate for the current configuration of the space program. The use of analogue environments and advanced statistical analysis are suggested as ways to address the limited spaceflight research opportunities. The challenge of research subject or patient confidentiality vs. mission safety and issues of personal flight status are addressed.

Maximum Oxygen Uptake During and After Long-Duration Space Flight

NASA Technical Reports Server (NTRS)

Moore, Alan D., Jr.; Evetts, Simon N.; Feiveson, Alan H.; Lee, Stuart M. C.; McCleary. Frank A.; Platts, Steven H.

2010-01-01

Decreased maximum oxygen consumption (VO2max) during and after space flight may impair a crewmember s ability to perform mission-critical work that is high intensity and/or long duration in nature (Human Research Program Integrated Research Plan Risk 2.1.2: Risk of Reduced Physical Performance Capabilities Due to Reduced Aerobic Capacity). When VO2max was measured in Space Shuttle experiments, investigators reported that it did not change during short-duration space flight but decreased immediately after flight. Similar conclusions, based on the heart rate (HR) response of Skylab crewmembers, were made previously concerning long-duration space flight. Specifically, no change in the in-flight exercise HR response in 8 of 9 Skylab crewmembers indicated that VO2max was maintained during flight, but the elevated exercise HR after flight indicated that VO2max was decreased after landing. More recently, a different pattern of in-flight exercise HR response, and assumed changes in VO2max, emerged from routine testing of International Space Station (ISS) crewmembers. Most ISS crewmembers experience an elevated in-flight exercise HR response early in their mission, with a gradual return toward preflight levels as the mission progresses. Similar to previous reports, exercise HR is elevated after ISS missions and returns to preflight levels by 30 days after landing. VO2max has not been measured either during or after long-duration space flight. The purposes of the ISS VO2max experiment are (1) to measure VO2max during and after long-duration spaceflight, and (2) to determine if submaximal exercise test results can be used to accurately estimate VO 2max.

Alendronate as an Effective Countermeasure to Disuse Induced Bone loss

NASA Technical Reports Server (NTRS)

LeBlanc, Adrian D.; Driscol, Theda B.; Shackelford, Linda C.; Evans, Harlan J.; Rianon, Nahid J.; Smith, Scott M.; Lai, Dejian

2002-01-01

Microgravity, similar to diuse immobilization on earth, causes rapid bone loss. This loss is believed to be an adaptive response to the reduced musculoskelatal forces in space and occurs gradually enough that changes occurring during short duration space flight are not a concern. Bone loss, however, will be a major impediment for long duration missions if effective countermeasures are not developed and implemented. Bed rest is used to simulate the reduced mechanical forces in humans and was used to test the hypothesis that oral alendronate would reduce the effects of long duration (17 weeks) inactivity on bone. Eight male subjects were given daily oral doses of alendronate during 17 weeks of horizontal bed rest and compared with 13 male control subjects not given the drug. Efficacy was evaluated based on measurements of bone markers, calcium balance and bone density performed before, during and after the bed rest. The results show that oral alendronate attenuates most of the characteristic changes associated with long duration bed rest and presumably space flight.

Semi-Autonomous Rodent Habitat for Deep Space Exploration

NASA Technical Reports Server (NTRS)

Alwood, J. S.; Shirazi-Fard, Y.; Pletcher, D.; Globus, R.

2018-01-01

NASA has flown animals to space as part of trailblazing missions and to understand the biological responses to spaceflight. Mice traveled in the Lunar Module with the Apollo 17 astronauts and now mice are frequent research subjects in LEO on the ISS. The ISS rodent missions have focused on unravelling biological mechanisms, better understanding risks to astronaut health, and testing candidate countermeasures. A critical barrier for longer-duration animal missions is the need for humans-in-the-loop to perform animal husbandry and perform routine tasks during a mission. Using autonomous or telerobotic systems to alleviate some of these tasks would enable longer-duration missions to be performed at the Deep Space Gateway. Rodent missions performed using the Gateway as a platform could address a number of critical risks identified by the Human Research Program (HRP), as well as Space Biology Program questions identified by NRC Decadal Survey on Biological and Physical Sciences in Space, (2011). HRP risk areas of potentially greatest relevance that the Gateway rodent missions can address include those related to visual impairment (VIIP) and radiation risks to central nervous system, cardiovascular disease, as well as countermeasure testing. Space Biology focus areas addressed by the Gateway rodent missions include mechanisms and combinatorial effects of microgravity and radiation. The objectives of the work proposed here are to 1) develop capability for semi-autonomous rodent research in cis-lunar orbit, 2) conduct key experiments for testing countermeasures against low gravity and space radiation. The hardware and operations system developed will enable experiments at least one month in duration, which potentially could be extended to one year in duration. To gain novel insights into the health risks to crew of deep space travel (i.e., exposure to space radiation), results obtained from Gateway flight rodents can be compared to ground control groups and separate groups of mice exposed to simulated Galactic Cosmic Radiation (at the NASA Space Radiation Lab). Results can then be compared to identical experiments conducted on the ISS. Together results from Gateway, ground-based, and ISS rodent experiments will provide novel insight into the effects of space radiation.

Accomplishments in Bioastronautics Research Aboard International Space Station

NASA Technical Reports Server (NTRS)

Uri, John J.

2003-01-01

The seventh long-duration expedition crew is currently in residence aboard International Space Station (ISS), continuing a permanent human presence in space that began in October 2000. During that time, expedition crews have been operators and subjects for 16 Human Life Sciences investigations, to gain a better understanding of the effects of long-duration space flight on the crew members and of the environment in which they live. Investigations have been conducted to study the radiation environment in the station as well as during extravehicular activity (EVA); bone demineralization and muscle deconditioning; changes in neuromuscular reflexes, muscle forces and postflight mobility; causes and possible treatment of postflight orthostatic intolerance; risk of developing kidney stones; changes in pulmonary function caused by long-duration flight as well as EVA; crew and crew-ground interactions; and changes in immune function. The experiment mix has included some conducted in flight aboard ISS as well as several which collected data only pre- and postflight. The conduct of these investigations has been facilitated by the Human Research Facility (HRF). HRF Rack 1 became the first research rack on ISS when it was installed in the US laboratory module Destiny in March 2001. The rack provides a core set of experiment hardware to support investigations, as well as power, data and commanding capability, and stowage. The second HRF rack, to complement the first with additional hardware and stowage capability, will be launched once Shuttle flights resume. Future years will see additional capability to conduct human research on ISS as International Partner modules and facility racks are added to ISS . Crew availability, both as a subject count and time, will remain a major challenge to maximizing the science return from the bioastronautics research program.

Management of Service Projects in Support of Space Flight Research

NASA Technical Reports Server (NTRS)

Love, J.

2009-01-01

Goal:To provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration . [HRP-47051] Specific Objectives: 1) Develop capabilities, necessary countermeasures, and technologies in support of human space exploration, focusing on mitigating the highest risks to human health and performance. 2) Define and improve human spaceflight medical, environmental, and human factors standards. 3) Develop technologies that serve to reduce medical and environmental risks, to reduce human systems resource requirements (mass, volume, power, data, etc.) and to ensure effective human-system integration across exploration systems. 4) Ensure maintenance of Agency core competencies necessary to enable risk reduction in the following areas: A. Space medicine B. Physiological and behavioral effects of long duration spaceflight on the human body C. Space environmental effects, including radiation, on human health and performance D. Space "human factors" [HRP-47051]. Service projects can form integral parts of research-based project-focused programs to provide specialized functions. Traditional/classic project management methodologies and agile approaches are not mutually exclusive paradigms. Agile strategies can be combined with traditional methods and applied in the management of service projects functioning in changing environments. Creative collaborations afford a mechanism for mitigation of constrained resource limitations.

Defining the Relationship Between Biomarkers of Oxidative and Inflammatory Stress and the Risk for Atherosclerosis in Astronauts During and After Long-Duration Spaceflight

NASA Technical Reports Server (NTRS)

Lee, S. M. C.; Martin, D. S.; Smith, S. M.; Zwart, S. R.; Laurie, S. S; Ribeiro, L. C.; Stenger, M. B.

2017-01-01

Current human space travel consists primarily of long-duration missions onboard the International Space Station (ISS), but in the future may include exploration-class missions to nearby asteroids, Mars, or its moons. These missions will expose astronauts to increased risk of oxidative and inflammatory damage from a variety of sources, including radiation, psychological stress, reduced physical activity, diminished nutritional status, and hyperoxic exposure during extravehicular activity. Evidence exists that increased oxidative stress and inflammation can accelerate the development of atherosclerosis.

Defining the Relationship Between Biomarkers of Oxidation and Inflammatory Stress and the Risk for Atherosclerosis in Astronauts During and After Long-Duration Spaceflight

NASA Technical Reports Server (NTRS)

Lee, Stuart M. C.; Stenger, Michael B.; Smith, Scott M.; Zwart, Sara R.

2016-01-01

Future human space travel will consist primarily of long-duration missions onboard the International Space Station (ISS) or exploration-class missions to Mars, its moons, or nearby asteroids. These missions will expose astronauts to increased risk of oxidative and inflammatory damage from a variety of sources, including radiation, psychological stress, reduced physical activity, diminished nutritional status, and hyperoxic exposure during extravehicular activity. Evidence exists that increased oxidative damage and inflammation can accelerate the development of atherosclerosis.

Minimizing Human Risk: Human Performance Models in the Space Human Factors and Habitability and Behavioral Health and Performance Elements

NASA Technical Reports Server (NTRS)

Gore, Brian F.

2016-01-01

Human space exploration has never been more exciting than it is today. Human presence to outer worlds is becoming a reality as humans are leveraging much of our prior knowledge to the new mission of going to Mars. Exploring the solar system at greater distances from Earth than ever before will possess some unique challenges, which can be overcome thanks to the advances in modeling and simulation technologies. The National Aeronautics and Space Administration (NASA) is at the forefront of exploring our solar system. NASA's Human Research Program (HRP) focuses on discovering the best methods and technologies that support safe and productive human space travel in the extreme and harsh space environment. HRP uses various methods and approaches to answer questions about the impact of long duration missions on the human in space including: gravity's impact on the human body, isolation and confinement on the human, hostile environments impact on the human, space radiation, and how the distance is likely to impact the human. Predictive models are included in the HRP research portfolio as these models provide valuable insights into human-system operations. This paper will provide an overview of NASA's HRP and will present a number of projects that have used modeling and simulation to provide insights into human-system issues (e.g. automation, habitat design, schedules) in anticipation of space exploration.

Cryogenic Propellant Storage and Transfer Technology Demonstration For Long Duration In-Space Missions

NASA Technical Reports Server (NTRS)

Meyer, Michael L.; Motil, Susan M.; Kortes, Trudy F.; Taylor, William J.; McRight, Patrick S.

2012-01-01

The high specific impulse of cryogenic propellants can provide a significant performance advantage for in-space transfer vehicles. The upper stages of the Saturn V and various commercial expendable launch vehicles have used liquid oxygen and liquid hydrogen propellants; however, the application of cryogenic propellants has been limited to relatively short duration missions due to the propensity of cryogens to absorb environmental heat resulting in fluid losses. Utilizing advanced cryogenic propellant technologies can enable the efficient use of high performance propellants for long duration missions. Crewed mission architectures for beyond low Earth orbit exploration can significantly benefit from this capability by developing realistic launch spacing for multiple launch missions, by prepositioning stages and by staging propellants at an in-space depot. The National Aeronautics and Space Administration through the Office of the Chief Technologist is formulating a Cryogenic Propellant Storage and Transfer Technology Demonstration Mission to mitigate the technical and programmatic risks of infusing these advanced technologies into the development of future cryogenic propellant stages or in-space propellant depots. NASA is seeking an innovative path for human space exploration, which strengthens the capability to extend human and robotic presence throughout the solar system. This mission will test and validate key cryogenic technological capabilities and has the objectives of demonstrating advanced thermal control technologies to minimize propellant loss during loiter, demonstrating robust operation in a microgravity environment, and demonstrating efficient propellant transfer on orbit. The status of the demonstration mission concept development, technology demonstration planning and technology maturation activities in preparation for flight system development are described.

Human-Centric Teaming in a Multi-Agent EVA Assembly Task

NASA Technical Reports Server (NTRS)

Rehnmark, Fredrik; Currie, Nancy; Ambrose, Robert O.; Culbert, Christopher

2004-01-01

NASA's Human Space Flight program depends heavily on spacewalks performed by pairs of suited human astronauts. These Extra-Vehicular Activities (EVAs) are severely restricted in both duration and scope by consumables and available manpower.An expanded multi-agent EVA team combining the information-gathering and problem-solving skills of human astronauts with the survivability and physical capabilities of highly dexterous space robots is proposed. A 1-g test featuring two NASA/DARPA Robonaut systems working side-by-side with a suited human subject is conducted to evaluate human-robot teaming strategies in the context of a simulated EVA assembly task based on the STS-61B ACCESS flight experiment.

Factors Impacting Habitable Volume Requirements for Long Duration Missions

NASA Technical Reports Server (NTRS)

Simon, Matthew; Neubek, Deborah; Whitmire, Alexandria

2012-01-01

One possible next leap in human space exploration for the National Aeronautics and Space Administration (NASA) is a mission to a near Earth asteroid (NEA). In order to achieve such an ambitious goal, a space habitat will need to accommodate a crew of four for the 380-day round trip. The Human Spaceflight Architecture Team (HAT) developed a conceptual design for such a habitat. The team identified activities that would be performed inside a long-duration, deep space habitat, and the capabilities needed to support such a mission. A list of seven functional activities/capabilities was developed: individual and group crew care, spacecraft and mission operations, subsystem equipment, logistics and resupply, and contingency operations. The volume for each activity was determined using NASA STD-3001 and the companion Human Integration Design Handbook (HIDH). Although, the sum of these volumes produced an over-sized spacecraft, the team evaluated activity frequency and duration to identify functions that could share a common volume without conflict, reducing the total volume by 24%. After adding 10% for growth, the resulting functional pressurized volume was calculated to be a minimum of 268 m3 (9,464 ft3) distributed over the functions. The work was validated through comparison to Mir, Skylab, the International Space Station (ISS), Bigelow Aerospace s proposed habitat module, and NASA s Trans-Hab concept. Using HIDH guidelines, the team developed an internal layout that (a) minimized the transit time between related crew stations, (b) accommodated expected levels of activity at each station, (c) isolated stations when necessary for health, safety, performance, and privacy, and (d) provided a safe, efficient, and comfortable work and living environment.

Applying a Crew Accommodations Resource Model to Future Space Vehicle Research

NASA Technical Reports Server (NTRS)

Blume, Jennifer Linda

2003-01-01

The success of research and development for human space flight depends heavily on modeling. In addition, the use of such models is especially critical at the earliest phase of research and development of any manned vehicle or habitat. NASA is currently studying various innovative and futuristic propulsion technologies to enable further exploration of space by untended as well as tended vehicles. Details such as vehicle mass, volume, shape and configuration are required variables to evaluate the success of the propulsion concepts. For tended vehicles, the impact of the crew's requirements on those parameters must be included. This is especially important on long duration missions where the crew requirements become more complex. To address these issues, a crew accommodations resource model, developed as a mission planning tool for human spaceflight (Stillwell, Boutros, & Connolly), was applied to a reference mission in order to estimate the volume and mass required to sustain a crew for a variety of long duration missions. The model, which compiled information from numerous different sources and contains various attributes which can be modified to enable comparisons across different dimensions, was instrumental in deriving volume and mass required for a tended long duration space flight. With the inclusion of some additional variables, a set of volume and mass requirements were provided to the project. If due consideration to crew requirements for volume and mass had not been entertained, the assumptions behind validation of the propulsion technology could have been found to be incorrect, possibly far into development of the technology or even into the design and build of test vehicles. The availability and use of such a model contributes significantly by increasing the accuracy of human space flight research and development activities and acts as a cost saving measure by preventing inaccurate assumptions from driving design decisions.

The Human Centrifuge

NASA Astrophysics Data System (ADS)

van Loon, Jack J. W. A.

2009-01-01

Life on Earth has developed at unit gravity, 9.81 m/s2, which was a major factor especially when vertebrates emerged from water onto land in the late Devonian, some 375 million years ago. But how would nature have evolved on a larger planet? We are able to address this question simply in experiments using centrifuges. Based on these studies we have gained valuable insights in the physiological process in plants and animals. They adapt to a new steady state suitable for the high-g environments applied. Information on mammalian adaptations to hyper-g is interesting or may be even vital for human space exploration programs. It has been shown in long duration animal hypergravity studies, ranging from snails, rats to primates, that various structures like muscles, bones, neuro-vestibular, or the cardio-vascular system are affected. However, humans have never been exposed to a hyper-g environment for long durations. Centrifuge studies involving humans are mostly in the order of hours. The current work on human centrifuges are all focused on short arm systems to apply short periods of artificial gravity in support of long duration space missions in ISS or to Mars. In this paper we will address the possible usefulness of a large human centrifuge on Earth. In such a centrifuge a group of humans can be exposed to hypergravity for, in principle, an unlimited period of time like living on a larger planet. The input from a survey under scientists working in the field of gravitational physiology, but also other disciplines, will be discussed.

A Modular Habitation System for Human Planetary and Space Exploration

NASA Technical Reports Server (NTRS)

Howe, A. Scott

2015-01-01

A small-diameter modular pressure vessel system is devised that can be applied to planetary surface and deep space human exploration missions. As one of the recommendations prepared for the NASA Human Spaceflight Architecture Team (HAT) Evolvable Mars Campaign (EMC), a compact modular system can provide a Mars-forward approach to a variety of missions and environments. Small cabins derived from the system can fit into the Space Launch System (SLS) Orion "trunk", or can be mounted with mobility systems to function as pressurized rovers, in-space taxis, ascent stage cabins, or propellant tanks. Larger volumes can be created using inflatable elements for long-duration deep space missions and planetary surface outposts. This paper discusses how a small-diameter modular system can address functional requirements, mass and volume constraints, and operational scenarios.

Approach and Issues Relating to Shield Material Design to Protect Astronauts from Space Radiation

NASA Technical Reports Server (NTRS)

Wilson, J. W.; Cucinotta, F. A.; Miller, J.; Shinn, J. L.; Thibeault, S. A.; Singleterry, R. C.; Simonsen, L. C.; Kim, M. H.

2001-01-01

One major obstacle to human space exploration is the possible limitations imposed by the adverse effects of long-term exposure to the space environment. Even before human spaceflight began, the potentially brief exposure of astronauts to the very intense random solar energetic particle (SEP) events was of great concern. A new challenge appears in deep space exploration from exposure to the low-intensity heavy-ion flux of the galactic cosmic rays (GCR) since the missions are of long duration and the accumulated exposures can be high. Since aluminum (traditionally used in spacecraft to avoid potential radiation risks) leads to prohibitively expensive mission launch costs, alternative materials need to be explored. An overview of the materials related issues and their impact on human space exploration will be given.

Simulation of Ophthalmic Alterations at the Arctic, Antarctica and the International Space Station for Long-Duration Spaceflight

NASA Astrophysics Data System (ADS)

De Morais Mendonca Teles, Antonio; Gonçalves, Cristiane

2016-07-01

Well, we propose a series of long-period medical simulations in scientific bases at the Arctic, at Antarctica and aboard the International Space Station (ISS), involving natural ophthalmic diseases such as radiation, solar and trauma retinopathy, keratoconus, cataract, glaucoma, etc., and ophthalmic alterations by accidental injuries. These natural diseases, without a previous diagnosis, specially those specific retinopathy, appear after 1 month to 1.5 year, in average. Such studies will be valuable for the human deep-space exploration because during long-duration spaceflight, such as staying at the ISS, a Moon base and a manned trip to planet Mars, requires several months within such environments, and during such periods ophthalmic diseases and accidents might eventually occur, which could seriously affect the 'round-the-clock' work schedule of the astronauts and the long-duration spaceflight manned program.

Current status and future direction of NASA's Space Life Sciences Program

NASA Technical Reports Server (NTRS)

White, Ronald J.; Lujan, Barbara F.

1989-01-01

The elements of the NASA Life Sciences Program that are related to manned space flight and biological scientific studies in space are reviewed. Projects included in the current program are outlined and the future direction of the program is discussed. Consideration is given to issues such as long-duration spaceflight, medical support in space, readaptation to the gravity field of earth, considerations for the Space Station, radiation hazards, environmental standards for space habitation, and human operator interaction with computers, robots, and telepresence systems.

Minimizing Human Risk: Human Performance Models in the Human Factors and Behavioral Performance Element

NASA Technical Reports Server (NTRS)

Gore, Brian F.

2017-01-01

Human space exploration has never been more exciting than it is today. Human presence to outer worlds is becoming a reality as humans are leveraging much of our prior knowledge to the new mission of going to Mars. Exploring the solar system at greater distances from Earth than ever before will possess some unique challenges, which can be overcome thanks to the advances in modeling and simulation technologies. The National Aeronautics and Space Administration (NASA) is at the forefront of exploring our solar system. NASA's Human Research Program (HRP) focuses on discovering the best methods and technologies that support safe and productive human space travel in the extreme and harsh space environment. HRP uses various methods and approaches to answer questions about the impact of long duration missions on the human in space including: gravitys impact on the human body, isolation and confinement on the human, hostile environments impact on the human, space radiation, and how the distance is likely to impact the human. Predictive models are included in the HRP research portfolio as these models provide valuable insights into human-system operations. This paper will provide an overview of NASA's HRP and will present a number of projects that have used modeling and simulation to provide insights into human-system issues (e.g. automation, habitat design, schedules) in anticipation of space exploration.

Human-Robot Teaming in a Multi-Agent Space Assembly Task

NASA Technical Reports Server (NTRS)

Rehnmark, Fredrik; Currie, Nancy; Ambrose, Robert O.; Culbert, Christopher

2004-01-01

NASA's Human Space Flight program depends heavily on spacewalks performed by pairs of suited human astronauts. These Extra-Vehicular Activities (EVAs) are severely restricted in both duration and scope by consumables and available manpower. An expanded multi-agent EVA team combining the information-gathering and problem-solving skills of humans with the survivability and physical capabilities of robots is proposed and illustrated by example. Such teams are useful for large-scale, complex missions requiring dispersed manipulation, locomotion and sensing capabilities. To study collaboration modalities within a multi-agent EVA team, a 1-g test is conducted with humans and robots working together in various supporting roles.

Development and Execution of Autonomous Procedures Onboard the International Space Station to Support the Next Phase of Human Space Exploration

NASA Technical Reports Server (NTRS)

Beisert, Susan; Rodriggs, Michael; Moreno, Francisco; Korth, David; Gibson, Stephen; Lee, Young H.; Eagles, Donald E.

2013-01-01

Now that major assembly of the International Space Station (ISS) is complete, NASA's focus has turned to using this high fidelity in-space research testbed to not only advance fundamental science research, but also demonstrate and mature technologies and develop operational concepts that will enable future human exploration missions beyond low Earth orbit. The ISS as a Testbed for Analog Research (ISTAR) project was established to reduce risks for manned missions to exploration destinations by utilizing ISS as a high fidelity micro-g laboratory to demonstrate technologies, operations concepts, and techniques associated with crew autonomous operations. One of these focus areas is the development and execution of ISS Testbed for Analog Research (ISTAR) autonomous flight crew procedures intended to increase crew autonomy that will be required for long duration human exploration missions. Due to increasing communications delays and reduced logistics resupply, autonomous procedures are expected to help reduce crew reliance on the ground flight control team, increase crew performance, and enable the crew to become more subject-matter experts on both the exploration space vehicle systems and the scientific investigation operations that will be conducted on a long duration human space exploration mission. These tests make use of previous or ongoing projects tested in ground analogs such as Research and Technology Studies (RATS) and NASA Extreme Environment Mission Operations (NEEMO). Since the latter half of 2012, selected non-critical ISS systems crew procedures have been used to develop techniques for building ISTAR autonomous procedures, and ISS flight crews have successfully executed them without flight controller involvement. Although the main focus has been preparing for exploration, the ISS has been a beneficiary of this synergistic effort and is considering modifying additional standard ISS procedures that may increase crew efficiency, reduce operational costs, and raise the amount of crew time available for scientific research. The next phase of autonomous procedure development is expected to include payload science and human research investigations. Additionally, ISS International Partners have expressed interest in participating in this effort. The recently approved one-year crew expedition starting in 2015, consisting of one Russian and one U.S. Operating Segment (USOS) crewmember, will be used not only for long duration human research investigations but also for the testing of exploration operations concepts, including crew autonomy.

Preliminary Assessment of Potential Habitat Composites' Durability when Exposed to a Long-Term Radiation Environment and Micrometeoroid Impacts

NASA Technical Reports Server (NTRS)

Rojdev, Kristina; Graves, Russell; Golden, John; Atwell, William; O'Rouke, Mary Jane; Hill, Charles; Alred, John

2011-01-01

NASA's exploration goals include extending human presence beyond low earth orbit (LEO). As a result, habitation for crew is a critical requirement for meeting this goal. However, habitats are very large structures that contain a multitude of subsystems to sustain human life over long-durations in space, and one of the key challenges has been keeping weight to a minimum in order to reduce costs. Thus, light-weight and multifunctional structural materials are of great interest for habitation. NASA has started studying polymeric composite materials as potential lightweight and multifunctional structural materials for use in long-duration spaceflight. However, little is known about the survivability of these materials when exposed to the space environment outside of LEO for long durations. Thus, a study has been undertaken to investigate the durability of composite materials when exposed to long-duration radiation. Furthermore, as an addition to the primary study, a secondary preliminary investigation has been started on the micrometeoroid and orbital debris (MMOD) susceptibility of these materials after radiation exposure. The combined effects of radiation and MMOD impacts are the focus of this paper.

Limitations in predicting the space radiation health risk for exploration astronauts.

PubMed

Chancellor, Jeffery C; Blue, Rebecca S; Cengel, Keith A; Auñón-Chancellor, Serena M; Rubins, Kathleen H; Katzgraber, Helmut G; Kennedy, Ann R

2018-01-01

Despite years of research, understanding of the space radiation environment and the risk it poses to long-duration astronauts remains limited. There is a disparity between research results and observed empirical effects seen in human astronaut crews, likely due to the numerous factors that limit terrestrial simulation of the complex space environment and extrapolation of human clinical consequences from varied animal models. Given the intended future of human spaceflight, with efforts now to rapidly expand capabilities for human missions to the moon and Mars, there is a pressing need to improve upon the understanding of the space radiation risk, predict likely clinical outcomes of interplanetary radiation exposure, and develop appropriate and effective mitigation strategies for future missions. To achieve this goal, the space radiation and aerospace community must recognize the historical limitations of radiation research and how such limitations could be addressed in future research endeavors. We have sought to highlight the numerous factors that limit understanding of the risk of space radiation for human crews and to identify ways in which these limitations could be addressed for improved understanding and appropriate risk posture regarding future human spaceflight.

NASA Utilization of the International Space Station and the Vision for Space Exploration

NASA Technical Reports Server (NTRS)

Robinson, Julie A.; Thumm, Tracy L.; Thomas, Donald A.

2006-01-01

In response to the U.S. President s Vision for Space Exploration (January 14, 2004), NASA has revised its utilization plans for ISS to focus on (1) research on astronaut health and the development of countermeasures that will protect our crews from the space environment during long duration voyages, (2) ISS as a test bed for research and technology developments that will insure vehicle systems and operational practices are ready for future exploration missions, (3) developing and validating operational practices and procedures for long-duration space missions. In addition, NASA will continue a small amount of fundamental research in life and microgravity sciences. There have been significant research accomplishments that are important for achieving the Exploration Vision. Some of these have been formal research payloads, while others have come from research based on the operation of International Space Station (ISS). We will review a selection of these experiments and results, as well as outline some of ongoing and upcoming research. The ISS represents the only microgravity opportunity to perform on-orbit long-duration studies of human health and performance and technologies relevant for future long-duration missions planned during the next 25 years. Even as NASA focuses on developing the Orion spacecraft and return to the moon (2015-2020), research on and operation of the ISS is fundamental to the success of NASA s Exploration Vision.

NASA Utilization of the International Space Station and the Vision for Space Exploration

NASA Technical Reports Server (NTRS)

Robinson, Julie A.; Thumm, Tracy L.; Thomas, Donald A.

2007-01-01

In response to the U.S. President s Vision for Space Exploration (January 14, 2004), NASA has revised its utilization plans for ISS to focus on (1) research on astronaut health and the development of countermeasures that will protect our crews from the space environment during long duration voyages, (2) ISS as a test bed for research and technology developments that will insure vehicle systems and operational practices are ready for future exploration missions, (3) developing and validating operational practices and procedures for long-duration space missions. In addition, NASA will continue a small amount of fundamental research in life and microgravity sciences. There have been significant research accomplishments that are important for achieving the Exploration Vision. Some of these have been formal research payloads, while others have come from research based on the operation of International Space Station (ISS). We will review a selection of these experiments and results, as well as outline some of ongoing and upcoming research. The ISS represents the only microgravity opportunity to perform on-orbit long-duration studies of human health and performance and technologies relevant for future long-duration missions planned during the next 25 years. Even as NASA focuses on developing the Orion spacecraft and return to the moon (2015-2020), research on and operation of the ISS is fundamental to the success of NASA s Exploration Vision.

NASA Utilization of the International Space Station and the Vision for Space Exploration

NASA Technical Reports Server (NTRS)

Robinson, Julie A.; Thomas, Donald A.; Thumm, Tracy L.

2006-01-01

In response to the U.S. President's Vision for Space Exploration (January 14, 2004), NASA has revised its utilization plans for ISS to focus on (1) research on astronaut health and the development of countermeasures that will protect our crews from the space environment during long duration voyages, (2) ISS as a test bed for research and technology developments that will insure vehicle systems and operational practices are ready for future exploration missions, (3) developing and validating operational practices and procedures for long-duration space missions. In addition, NASA will continue a small amount of fundamental research in life and microgravity sciences. There have been significant research accomplishments that are important for achieving the Exploration Vision. Some of these have been formal research payloads, while others have come from research based on the operation of International Space Station (ISS). We will review a selection of these experiments and results, as well as outline some of ongoing and upcoming research. The ISS represents the only microgravity opportunity to perform on-orbit long-duration studies of human health and performance and technologies relevant for future long-duration missions planned during the next 25 years. Even as NASA focuses on developing the Orion spacecraft and return to the moon (2015-2020), research on and operation of the ISS is fundamental to the success of NASA s Exploration Vision.

NASA Exploration Team (NExT) In-Space Transportation Overview

NASA Technical Reports Server (NTRS)

Drake, Bret G.; Cooke, Douglas R.; Kos, Larry D.; Brady, Hugh J. (Technical Monitor)

2002-01-01

This presentation provides an overview of NASA Exploration Team's (NEXT) vision of in-space transportation in the future. Hurdles facing in-space transportation include affordable power sources, crew health and safety, optimized robotic and human operations and space systems performance. Topics covered include: exploration of Earth's neighborhood, Earth's neighborhood architecture and elements, Mars mission trajectory options, delta-v variations, Mars mission duration options, Mars mission architecture, nuclear electric propulsion advantages and miscellaneous technology needs.

Adaptation of heart rate and blood pressure to short and long duration space missions.

PubMed

Verheyden, Bart; Liu, Jiexin; Beckers, Frank; Aubert, André E

2009-10-01

To what extent does going to space affect cardiovascular function? Although many studies have addressed this question, the answer remains controversial. Even for such primary parameters as heart rate (HR) and blood pressure (BP) contradictory results have been presented. The purpose of this investigation was to evaluate HR and arterial BP in 11 male astronauts who each took part in nine different space missions aboard the International Space Station (ISS), for up to 6 months. Pre-flight HR and BP readings were obtained in both the standing and supine positions on Earth and were taken as reference values. Our results show that HR and arterial BP in space equal pre-flight supine values. In all subjects, HR and mean arterial BP (MAP) were lower in space compared with pre-flight standing (both p<0.05). HR in space was well maintained at pre-flight supine level for up to 6 months in all astronauts while MAP tended to adapt to a level in between the ground-based standing and supine positions. Also pulse pressure (PP) decreased over the course of long duration spaceflight. In conclusion, our data indicate that weightlessness relaxes the circulation in humans for an extended duration of up to 6 months in space.

[Bone metabolism in human space flight and bed rest study].

PubMed

Ohshima, Hiroshi; Mukai, Chiaki

2008-09-01

Japanese Experiment Module "KIBO" is Japan's first manned space facility and will be operated as part of the international space station (ISS) . KIBO operations will be monitored and controlled from Tsukuba Space Center. In Japan, after the KIBO element components are fully assembled and activated aboard the ISS, Japanese astronauts will stay on the ISS for three or more months, and full-scale experiment operations will begin. Bone loss and renal stone are significant medical concerns for long duration human space flight. This paper will summarize the results of bone loss, calcium balance obtained from the American and Russian space programs, and ground-base analog bedrest studies. Current in-flight training program, nutritional recommendations and future countermeasure plans for station astronauts are also described.

View of human problems to be addressed for long-duration space flights

NASA Technical Reports Server (NTRS)

Berry, C. A.

1973-01-01

Review of the principal physiological changes seen in space flight, and discussion of various countermeasures which may prove to be useful in combating these changes in long-term space flight. A number of transient changes seen in Apollo astronauts following space flights are discussed, including cardiovascular and hemodynamic responses to weightlessness, musculoskeletal changes, changes in fluid and electrolyte balance, microbiological changes, and vestibular effects. A number of countermeasures to the effects of space flight on man are cited, including exercise, medication, diet, lower-body negative pressure, gradient positive pressure, venous occlusion cuffs, and others. A detailed review is then made of a number of psychological factors bearing on the ability of the human organism to withstand the rigors of long space flights.

Human factors technology for America's space program

NASA Technical Reports Server (NTRS)

Montemerlo, M. D.

1982-01-01

NASA is initiating a space human factors research and technology development program in October 1982. The impetus for this program stems from: the frequent and economical access to space provided by the Shuttle, the advances in control and display hardware/software made possible through the recent explosion in microelectronics technology, heightened interest in a space station, heightened interest by the military in space operations, and the fact that the technology for long duration stay times for man in space has received relatively little attention since the Apollo and Skylab missions. The rationale for and issues in the five thrusts of the new program are described. The main thrusts are: basic methodology, crew station design, ground control/operations, teleoperations and extra vehicular activity.

International Space Station medical standards and certification for space flight participants.

PubMed

Bogomolov, Valery V; Castrucci, Filippo; Comtois, Jean-Marc; Damann, Volker; Davis, Jeffrey R; Duncan, J Michael; Johnston, Smith L; Gray, Gary W; Grigoriev, Anatoly I; Koike, Yu; Kuklinski, Paul; Matveyev, Vladimir P; Morgun, Valery V; Pochuev, Vladimir I; Sargsyan, Ashot E; Shimada, Kazuhito; Straube, Ulrich; Tachibana, Shoichi; Voronkov, Yuri V; Williams, Richard S

2007-12-01

The medical community of the International Space Station (ISS) has developed joint medical standards and evaluation requirements for Space Flight Participants ("space tourists") which are used by the ISS medical certification board to determine medical eligibility of individuals other than professional astronauts (cosmonauts) for short-duration space flight to the ISS. These individuals are generally fare-paying passengers without operational responsibilities. By means of this publication, the medical standards and evaluation requirements for the ISS Space Flight Participants are offered to the aerospace medicine and commercial spaceflight communities for reference purposes. It is emphasized that the criteria applied to the ISS spaceflight participant candidates are substantially less stringent than those for professional astronauts and/or crewmembers of visiting and long-duration missions to the ISS. These medical standards are released by the government space agencies to facilitate the development of robust medical screening and medical risk assessment approaches in the context of the evolving commercial human spaceflight industry.

Addressing Human System Risks to Future Space Exploration

NASA Technical Reports Server (NTRS)

Paloski, W. H.; Francisco, D. R.; Davis, J. R.

2015-01-01

NASA is contemplating future human exploration missions to destinations beyond low Earth orbit, including the Moon, deep-space asteroids, and Mars. While we have learned much about protecting crew health and performance during orbital space flight over the past half-century, the challenges of these future missions far exceed those within our current experience base. To ensure success in these missions, we have developed a Human System Risk Board (HSRB) to identify, quantify, and develop mitigation plans for the extraordinary risks associated with each potential mission scenario. The HSRB comprises research, technology, and operations experts in medicine, physiology, psychology, human factors, radiation, toxicology, microbiology, pharmacology, and food sciences. Methods: Owing to the wide range of potential mission characteristics, we first identified the hazards to human health and performance common to all exploration missions: altered gravity, isolation/confinement, increased radiation, distance from Earth, and hostile/closed environment. Each hazard leads to a set of risks to crew health and/or performance. For example the radiation hazard leads to risks of acute radiation syndrome, central nervous system dysfunction, soft tissue degeneration, and carcinogenesis. Some of these risks (e.g., acute radiation syndrome) could affect crew health or performance during the mission, while others (e.g., carcinogenesis) would more likely affect the crewmember well after the mission ends. We next defined a set of design reference missions (DRM) that would span the range of exploration missions currently under consideration. In addition to standard (6-month) and long-duration (1-year) missions in low Earth orbit (LEO), these DRM include deep space sortie missions of 1 month duration, lunar orbital and landing missions of 1 year duration, deep space journey and asteroid landing missions of 1 year duration, and Mars orbital and landing missions of 3 years duration. We then assessed the likelihood and consequences of each risk against each DRM, using three levels of likelihood (Low: less than or equal to 0.1%; Medium: 0.1%–1.0%; High: greater than or equal to 1.0%) and four levels of consequence ranging from Very Low (temporary or insignificant) to High (death, loss of mission, or significant reduction to length or quality of life). Quantitative evidence from clinical, operational, and research sources were used whenever available. Qualitative evidence was used when quantitative evidence was unavailable. Expert opinion was used whenever insufficient evidence was available. Results: A set of 30 risks emerged that will require further mitigation efforts before being accepted by the Agency. The likelihood by consequence risk assessment process provided a means of prioritizing among the risks identified. For each of the high priority risks, a plan was developed to perform research, technology, or standards development thought necessary to provide suitable reduction of likelihood or consequence to allow agency acceptance. Conclusion: The HSRB process has successfully identified a complete set of risks to human space travelers on planned exploration missions based on the best evidence available today. Risk mitigation plans have been established for the highest priority risks. Each risk will be reassessed annually to track the progress of our risk mitigation efforts.

Deep Space Habitat ECLSS Design Concept

NASA Technical Reports Server (NTRS)

Curley, Su; Stambaugh, Imelda; Swickrath, Michael; Anderson, Molly S.; Rotter, Henry

2012-01-01

Life support is vital to human spaceflight, and most current life support systems employ single-use hardware or regenerable technologies that throw away the waste products, relying on resupply to make up the consumables lost in the process. Because the long-term goal of the National Aeronautics and Space Administration is to expand human presence beyond low-earth orbit, life support systems must become self-sustaining for missions where resupply is not practical. From May through October 2011, the life support team at the Johnson Space Center was challenged to define requirements, develop a system concept, and create a preliminary life support system design for a non-planetary Deep Space Habitat that could sustain a crew of four in near earth orbit for a duration of 388 days. Some of the preferred technology choices to support this architecture were passed over because the mission definition has an unmanned portion lasting 825 days. The main portion of the architecture was derived from technologies currently integrated on the International Space Station as well as upcoming technologies with moderate Technology Readiness Levels. The final architecture concept contains only partially-closed air and water systems, as the breakeven point for some of the closure technologies was not achieved with the mission duration.

Deep Space Habitat ECLS Design Concept

NASA Technical Reports Server (NTRS)

Curley, Su; Stambaugh, Imelda; Swickrath, Mike; Anderson, Molly; Rotter, Hank

2011-01-01

Life support is vital to human spaceflight, and most current life support systems employ single-use hardware or regenerable technologies that throw away the waste products, relying on resupply to make up the consumables lost in the process. Because the long-term goal of the National Aeronautics and Space Administration is to expand human presence beyond low-earth orbit, life support systems must become self-sustaining for missions where resupply is not practical. From May through October 2011, the life support team at the Johnson Space Center was challenged to define requirements, develop a system concept, and create a preliminary life support system design for a non-planetary Deep Space Habitat that could sustain a crew of four in near earth orbit for a duration of 388 days. Some of the preferred technology choices to support this architecture were passed over as the mission definition also has an unmanned portion lasting 825 days. The main portion of the architecture was derived from technologies currently integrated on the International Space Station as well as upcoming technologies with moderate Technology Readiness Levels. The final architecture concept contains only partially-closed air and water systems, as the breakeven point for some of the closure technologies was not achieved with the mission duration.

Effect of Microgravity on Bone Tissue and Calcium Metabolism

NASA Technical Reports Server (NTRS)

1997-01-01

Session TA4 includes short reports concerning: (1) Human Bone Tissue Changes after Long-Term Space Flight: Phenomenology and Possible Mechanics; (2) Prediction of Femoral Neck Bone Mineral Density Change in Space; (3) Dietary Calcium in Space; (4) Calcium Metabolism During Extended-Duration Space Flight; (5) External Impact Loads on the Lower Extremity During Jumping in Simulated Microgravity and the Relationship to Internal Bone Strain; and (6) Bone Loss During Long Term Space Flight is Prevented by the Application of a Short Term Impulsive Mechanical Stimulus.

Fundamentals of Space Medicine

NASA Astrophysics Data System (ADS)

Clément, G.

2003-10-01

As of today, a total of more than 240 human space flights have been completed, involving about 450 astronauts from various countries, for a combined total presence in space of more than 70 years. The seventh long-duration expedition crew is currently in residence aboard the International Space Station, continuing a permanent presence in space that began in October 2000. During that time, investigations have been conducted on both humans and animal models to study the bone demineralization and muscle deconditioning, space motion sickness, the causes and possible treatment of postflight orthostatic intolerance, the changes in immune function, crew and crew-ground interactions, and the medical issues of living in a space environment, such as the effects of radiation or the risk of developing kidney stones. Some results of these investigations have led to fundamental discoveries about the adaptation of the human body to the space environment. Gilles Clément has been active in this research. This book presents in a readable text the findings from the life science experiments conducted during and after space missions. Topics discussed in this book include: adaptation of sensory-motor, cardiovascular, bone and muscle systems to the microgravity of spaceflight; psychological and sociological issues of living in a confined, isolated and stressful environment; operational space medicine, such as crew selection, training and in-flight health monitoring, countermeasures and support; results of space biology experiments on individual cells, plants, and animal models; and the impact of long-duration missions such as the human mission to Mars. The author also provides a detailed description of how to fly a space experiment, based on his own experience with research projects conducted onboard Salyut-7, Mir, Spacelab, and the Space Shuttle. Now is the time to look at the future of human spaceflight and what comes next. The future human exploration of Mars captures the imagination of both the public and the scientific community. Many physiological, psychological, operational, and scientific issues need to be solved before the first crew will explore the enigmatic Red Planet. This book also identifies the showstoppers that can be foreseen and what do we need to learn to understand fully the implications and risks of such a mission. Link: http://www.wkap.nl/prod/b/1-4020-1598-4>

Nutrition in space - Evidence from the U.S. and the U.S.S.R

NASA Technical Reports Server (NTRS)

Lane, Helen W.

1992-01-01

Space flight exposes humans to a hostile, stressful environment as well as to the weightlessness associated with microgravity. The stresses of space travel affect nutritional balance, as evidenced by interrelated changes in body composition, energy utilization, and endocrine function. The limited data gathered thus far suggest that space flight incurs acute decreases in fluid mass and chronic, ongoing changes in muscle and bone mass. Concurrent with these changes is an increase in energy used per unit body mass. Other preliminary data suggest that bed rest and space flight may incur increased sensitivity to insulin. Further research is needed to determine the human energy and protein requirements for space, as well as a means of quantifying changes in body composition during extended-duration space flight.

Space life and biomedical sciences in support of the global exploration roadmap and societal development

NASA Astrophysics Data System (ADS)

Evetts, S. N.

2014-08-01

The human exploration of space is pushing the boundaries of what is technically feasible. The space industry is preparing for the New Space era, the momentum for which will emanate from the commercial human spaceflight sector, and will be buttressed by international solar system exploration endeavours. With many distinctive technical challenges to be overcome, human spaceflight requires that numerous biological and physical systems be examined under exceptional circumstances for progress to be made. To effectively tackle such an undertaking significant intra- and international coordination and collaboration is required. Space life and biomedical science research and development (R & D) will support the Global Exploration Roadmap (GER) by enabling humans to 'endure' the extreme activity that is long duration human spaceflight. In so doing the field will discover solutions to some of our most difficult human health issues, and as a consequence benefit society as a whole. This space-specific R&D will drive a significant amount of terrestrial biomedical research and as a result the international community will not only gain benefits in the form of improved healthcare in space and on Earth, but also through the growth of its science base and industry.

Aerospace Medicine Talk

NASA Technical Reports Server (NTRS)

Williams, Richard S.

2015-01-01

The presentation is next Sunday, May 10th. It will be to the Civil Aviation Medical Association, for 2 hours at Disney World in Orlando. It is a high level talk on space medicine, including history, the role of my office, human health risks of space flight, general aspects of space medicine practice, human health risk management (including integrated activities of medical operations and the Human Research Program, and thoughts concerning health risks for long duration exploration class space missions. No proprietary data or material will be used, all is readily available in the public sector. There is also a short (30 min) talk on Monday at the CAMA lunch. There we will describe the Visual Impairment and Intracranial Pressure syndrome, with possible etiologies and plans for research (already selected studies). Again, nothing proprietary will be discussed.

Paving the Path for Human Space Exploration: The Challenges and Opportunities

NASA Technical Reports Server (NTRS)

Hansen, Lauri

2016-01-01

Lauri Hansen, Director of Engineering at NASA Johnson Space Center will discuss the challenges of human space exploration. The future of human exploration begins with our current earth reliant missions in low earth orbit. These missions utilize the International Space Station to learn how to safely execute deep space missions. In addition to serving as an exploration test bed and enabling world class research, the International Space Station enables NASA to build international and commercial partnerships. NASA's next steps will be to enable the commercialization of low earth orbit while concentrating on developing the spacecraft and infrastructure necessary for deep space exploration and long duration missions. The Orion multi-purpose crew vehicle and the Space Launch System rocket are critical building blocks in this next phase of exploration. There are many challenges in designing spacecraft to perform these missions including safety, complex vehicle design, and mass challenges. Orion development is proceeding well, and includes a significant partnership with the European Space Agency (ESA) to develop and build the Service Module portion of the spacecraft. Together, NASA and ESA will provide the capability to take humans further than we have ever been before - 70,000 km past the moon. This will be the next big step in expanding the frontiers of human exploration, eventually leading to human footprints on Mars.

[SYMPTOMS OF NEGATIVE EFFECTS CUMULATION IN HUMANS AND ANIMALS UNDER THE ACTION OF G-LOADS OF VARYING DIRECTION IN CONTEXT OF AVIATION AND SPACE FLIGHTS].

PubMed

Kotovskaya, A R

2015-01-01

Author's and literary data are analyzed to evince symptoms of cumulation in humans and animals of the negative effects caused by g-forces of different directions experienced in aviation and space flights. The author cites evidence for the decisive importance of g-duration for the development of negative effects. Functional indices of g-tolerance do not rule out possible latent changes in visceral organs and body tissues.

Nutrition in space: lessons from the past applied to the future.

PubMed

Lane, H W; Smith, S M; Rice, B L; Bourland, C T

1994-11-01

From the basic impact of nutrient intake on health maintenance to the psychosocial benefits of mealtime, the role of nutrition in space is evident. In this discussion, dietary intake data from three space programs, Apollo, Space Shuttle, and Skylab, are presented. Data examination reveals that energy and fluid intakes are almost always lower than predicted. Nutrition in space has many areas of impact, including provision of required nutrients and maintenance of endocrine, immune, and musculoskeletal systems. Long-duration missions will require quantitation of nutrient requirements for maintenance of health and protection against the effects of microgravity. Psychosocial aspects of nutrition will also be important for more productive missions and crew morale. Realization of the full role of nutrition during spaceflight is critical for the success of extended-duration missions. Research conducted to determine the impact of spaceflight on human physiology and subsequent nutritional requirements will also have direct and indirect applications in Earth-based nutrition research.

Architectures for Human Exploration of Near Earth Asteroids

NASA Technical Reports Server (NTRS)

Drake, Bret G.

2011-01-01

The presentation explores human exploration of Near Earth Asteroid (NEA) key factors including challenges of supporting humans for long-durations in deep-space, incorporation of advanced technologies, mission design constraints, and how many launches are required to conduct a round trip human mission to a NEA. Topics include applied methodology, all chemical NEA mission operations, all nuclear thermal propulsion NEA mission operations, SEP only for deep space mission operations, and SEP/chemical hybrid mission operations. Examples of mass trends between datasets are provided as well as example sensitivity of delta-v and trip home, sensitivity of number of launches and trip home, and expected targets for various transportation architectures.

Space Human Factors Engineering Gap Analysis Project Final Report

NASA Technical Reports Server (NTRS)

Hudy, Cynthia; Woolford, Barbara

2006-01-01

Humans perform critical functions throughout each phase of every space mission, beginning with the mission concept and continuing to post-mission analysis (Life Sciences Division, 1996). Space missions present humans with many challenges - the microgravity environment, relative isolation, and inherent dangers of the mission all present unique issues. As mission duration and distance from Earth increases, in-flight crew autonomy will increase along with increased complexity. As efforts for exploring the moon and Mars advance, there is a need for space human factors research and technology development to play a significant role in both on-orbit human-system interaction, as well as the development of mission requirements and needs before and after the mission. As part of the Space Human Factors Engineering (SHFE) Project within the Human Research Program (HRP), a six-month Gap Analysis Project (GAP) was funded to identify any human factors research gaps or knowledge needs. The overall aim of the project was to review the current state of human factors topic areas and requirements to determine what data, processes, or tools are needed to aid in the planning and development of future exploration missions, and also to prioritize proposals for future research and technology development.

Artificial Gravity as a Multi-System Countermeasure for Exploration Class Space Flight Missions

NASA Technical Reports Server (NTRS)

Paloski, William H.; Dawson, David L. (Technical Monitor)

2000-01-01

NASA's vision for space exploration includes missions of unprecedented distance and duration. However, during 30 years of human space flight experience, including numerous long-duration missions, research has not produced any single countermeasure or combination of countermeasures that is completely effective. Current countermeasures do not fully protect crews in low-Earth orbit, and certainly will not be appropriate for crews journeying to Mars and back over a three-year period. The urgency for exploration-class countermeasures is compounded by continued technical and scientific successes that make exploration class missions increasingly attractive. The critical and possibly fatal problems of bone loss, cardiovascular deconditioning, muscle weakening, neurovestibular disturbance, space anemia, and immune compromise may be alleviated by the appropriate application of artificial gravity (AG). However, despite a manifest need for new countermeasure approaches, concepts for applying AG as a countermeasure have not developed apace. To explore the utility of AG as a multi-system countermeasure during long-duration, exploration-class space flight, eighty-three members of the international space life science and space flight community met earlier this year. They concluded unanimously that the potential of AG as a multi-system countermeasure is indeed worth pursuing, and that the requisite AG research needs to be supported more systematically by NASA. This presentation will review the issues discussed and recommendations made.

The clinical chemistry and immunology of long-duration space missions.

PubMed

Wu, A H; Taylor, G R; Graham, G A; McKinley, B A

1993-01-01

Clinical laboratory diagnostic capabilities are needed to guide health and medical care of astronauts during long-duration space missions. Clinical laboratory diagnostics, as defined for medical care on Earth, offers a model for space capabilities. Interpretation of laboratory results for health and medical care of humans in space requires knowledge of specific physiological adaptations that occur, primarily because of the absence of gravity, and how these adaptations affect reference values. Limited data from American and Russian missions have indicated shifts of intra- and extracellular fluids and electrolytes, changes in hormone concentrations related to fluid shifts and stresses of the missions, reductions in bone and muscle mass, and a blunting of the cellular immune response. These changes could increase susceptibility to space-related illness or injury during a mission and after return to Earth. We review physiological adaptations and the risk of medical problems that occur during space missions. We describe the need for laboratory diagnostics as a part of health and medical care in space, and how this capability might be delivered.

Microbial Monitoring of Crewed Habitats in Space—Current Status and Future Perspectives

PubMed Central

Yamaguchi, Nobuyasu; Roberts, Michael; Castro, Sarah; Oubre, Cherie; Makimura, Koichi; Leys, Natalie; Grohmann, Elisabeth; Sugita, Takashi; Ichijo, Tomoaki; Nasu, Masao

2014-01-01

Previous space research conducted during short-term flight experiments and long-term environmental monitoring on board orbiting space stations suggests that the relationship between humans and microbes is altered in the crewed habitat in space. Both human physiology and microbial communities adapt to spaceflight. Microbial monitoring is critical to crew safety in long-duration space habitation and the sustained operation of life support systems on space transit vehicles, space stations, and surface habitats. To address this critical need, space agencies including NASA (National Aeronautics and Space Administration), ESA (European Space Agency), and JAXA (Japan Aerospace Exploration Agency) are working together to develop and implement specific measures to monitor, control, and counteract biological contamination in closed-environment systems. In this review, the current status of microbial monitoring conducted in the International Space Station (ISS) as well as the results of recent microbial spaceflight experiments have been summarized and future perspectives are discussed. PMID:25130885

Using the Moon as a high-fidelity analogue environment to study biological and behavioral effects of long-duration space exploration

NASA Astrophysics Data System (ADS)

Goswami, Nandu; Roma, Peter G.; De Boever, Patrick; Clément, Gilles; Hargens, Alan R.; Loeppky, Jack A.; Evans, Joyce M.; Peter Stein, T.; Blaber, Andrew P.; Van Loon, Jack J. W. A.; Mano, Tadaaki; Iwase, Satoshi; Reitz, Guenther; Hinghofer-Szalkay, Helmut G.

2012-12-01

Due to its proximity to Earth, the Moon is a promising candidate for the location of an extra-terrestrial human colony. In addition to being a high-fidelity platform for research on reduced gravity, radiation risk, and circadian disruption, the Moon qualifies as an isolated, confined, and extreme (ICE) environment suitable as an analog for studying the psychosocial effects of long-duration human space exploration missions and understanding these processes. In contrast, the various Antarctic research outposts such as Concordia and McMurdo serve as valuable platforms for studying biobehavioral adaptations to ICE environments, but are still Earth-bound, and thus lack the low-gravity and radiation risks of space. The International Space Station (ISS), itself now considered an analog environment for long-duration missions, better approximates the habitable infrastructure limitations of a lunar colony than most Antarctic settlements in an altered gravity setting. However, the ISS is still protected against cosmic radiation by the Earth magnetic field, which prevents high exposures due to solar particle events and reduces exposures to galactic cosmic radiation. On Moon the ICE environments are strengthened, radiations of all energies are present capable of inducing performance degradation, as well as reduced gravity and lunar dust. The interaction of reduced gravity, radiation exposure, and ICE conditions may affect biology and behavior - and ultimately mission success - in ways the scientific and operational communities have yet to appreciate, therefore a long-term or permanent human presence on the Moon would ultimately provide invaluable high-fidelity opportunities for integrated multidisciplinary research and for preparations of a manned mission to Mars.

Stressors, stress and stress consequences during long-duration manned space missions: a descriptive model

NASA Astrophysics Data System (ADS)

Geuna, Stefano; Brunelli, Francesco; Perino, Maria A.

Keeping crew members in good health is a major factor in the success or failure of long-duration manned space missions. Among the many possible agents that can affect the crew's general well-being, stress is certainly one of the most critical because of its implications on human health and performance, both physical and mental. Nevertheless, very few studies have been performed on this fundamental issue and none of them has addressed it in its entirity, considering its diverse physical and psychological aspects. In this work, a descriptive model is proposed to expound the mechanism and sequence of events which mediate stress. A critical analysis of the information provided by past manned spaceflights and by dedicated research performed in analogous environments is presented, and an extrapolation of the available data on human stress in such extreme conditions is proposed. Both internal and external stressors have been identified, at physical and psychosocial levels, thus providing the basis for their early detection and preventive reduction. The possible negative consequences of stress that may lead to disease in crewmembers are described. Finally, the most effective instruments which may be of help in reducing space-related human stress and treating its negative consequences are suggested.

Biomedical research on the International Space Station postural and manipulation problems of the human upper limb in weightlessness

NASA Astrophysics Data System (ADS)

Neri, Gianluca; Zolesi, Valfredo

2000-01-01

Accumulated evidence, based on information gathered on space flight missions and ground based models involving both humans and animals, clearly suggests that exposure to states of microgravity conditions for varying duration induces certain physiological changes; they involve cardiovascular deconditioning, balance disorders, bone weakening, muscle hypertrophy, disturbed sleep patterns and depressed immune responses. The effects of the microgravity on the astronauts' movement and attitude have been studied during different space missions, increasing the knowledge of the human physiology in weightlessness. The purpose of the research addressed in the present paper is to understand and to assess the performances of the upper limb, especially during grasp. Objects of the research are the physiological changes related to the long-term duration spaceflight environment. Specifically, the changes concerning the upper limb are investigated, with particular regard to the performances of the hand in zero-g environments. This research presents also effects on the Earth, improving the studies on a number of pathological states, on the health care and the rehabilitation. In this perspective, a set of experiments are proposed, aimed at the evaluation of the effects of the zero-g environments on neurophysiology of grasping movements, fatigue assessment, precision grip. .

Human response to vibroacoustic environments of space vehicles

NASA Technical Reports Server (NTRS)

Willshire, K. F.

1984-01-01

To insure efficient utilization of the system, space station design and operations will require special habitability considerations for the occupants and crew because of the relatively long duration missions. Of particular concern is the environment in which the personnel will live and work, and how it affects both the performance and comfort of the occupants. Current criteria do not consider possible effects of reduced gravity, long duration, and confinement. Preliminary to developing space station vibroacoustic habitability criteria, the adequacy of criteria for other space vehicles has been reviewed. In this paper, responses to the noise and vibration environments of both Skylab and Shuttle are discussed. Some astronauts have reported sleep interference, communication interference, distraction, and general annoyance as noise related complaints. In addition, information from the Russian Salyut missions, as well as similar based situtations (e.g., submarines), is reviewed.

Human response to vibroacoustic environments of space vehicles

NASA Astrophysics Data System (ADS)

Willshire, K. F.

1984-10-01

To insure efficient utilization of the system, space station design and operations will require special habitability considerations for the occupants and crew because of the relatively long duration missions. Of particular concern is the environment in which the personnel will live and work, and how it affects both the performance and comfort of the occupants. Current criteria do not consider possible effects of reduced gravity, long duration, and confinement. Preliminary to developing space station vibroacoustic habitability criteria, the adequacy of criteria for other space vehicles has been reviewed. In this paper, responses to the noise and vibration environments of both Skylab and Shuttle are discussed. Some astronauts have reported sleep interference, communication interference, distraction, and general annoyance as noise related complaints. In addition, information from the Russian Salyut missions, as well as similar based situtations (e.g., submarines), is reviewed.

Exploration-Related Research on ISS: Connecting Science Results to Future Missions

NASA Technical Reports Server (NTRS)

Rhatigan, Jennifer L.; Robinson, Julie A.; Sawin, Charles F.

2005-01-01

In January, 2004, the U.S. President announced The Vision for Space Exploration, and charged the National Aeronautics and Space Administration (NASA) with using the International Space Station (ISS) for research and technology targeted at supporting U.S. space exploration goals. This paper describes: What we have learned from the first four years of research on ISS relative to the exploration mission; The on-going research being conducted in this regard; and Our current understanding of the major exploration mission risks that the ISS can be used to address. Specifically, we discuss research carried out on the ISS to determine the mechanisms by which human health is affected on long-duration missions, and to develop countermeasures to protect humans from the space environment. These bioastronautics experiments are key enablers of future long duration human exploration missions. We also discuss how targeted technological developments can enable mission design trade studies. We discuss the relationship between the ultimate number of human test subjects available on the ISS to the quality and quantity of scientific insight that can be used to reduce health risks to future explorers. We discuss the results of NASA's efforts over the past year to realign the ISS research programs to support a product-driven portfolio that is directed towards reducing the major risks of exploration missions. The fundamental challenge to science on ISS is completing experiments that answer key questions in time to shape design decisions for future exploration. In this context, exploration relevant research must do more than be conceptually connected to design decisions - it must become a part of the mission design process.

International Space Station Human Behavior and Performance Competency Model: Volume II

NASA Technical Reports Server (NTRS)

Schmidt, Lacey

2008-01-01

This document further defines the behavioral markers identified in the document "Human Behavior and Performance Competency Model" Vol. I. The Human Behavior and Performance (HBP) competencies were recommended as requirements to participate in international long duration missions, and form the basis for determining the HBP training curriculum for long duration crewmembers. This document provides details, examples, knowledge areas, and affective skills to support the use of the HBP competencies in training and evaluation. This document lists examples and details specific to HBP competencies required of astronauts/cosmonauts who participate in ISS expedition and other international long-duration missions. Please note that this model does not encompass all competencies required. While technical competencies are critical for crewmembers, they are beyond the scope of this document. Additionally, the competencies in this model (and subsequent objectives) are not intended to limit the internal activities or training programs of any international partner.

A Flexible Path for Human and Robotic Space Exploration

NASA Technical Reports Server (NTRS)

Korsmeyer, David J.; Landis, Robert; Merrill, Raymond Gabriel; Mazanek, Daniel D.; Falck, Robert D.; Adams, Robert B.

2010-01-01

During the summer of 2009, a flexible path scenario for human and robotic space exploration was developed that enables frequent, measured, and publicly notable human exploration of space beyond low-Earth orbit (LEO). The formulation of this scenario was in support of the Exploration Beyond LEO subcommittee of the Review of U.S. Human Space Flight Plans Committee that was commissioned by President Obama. Exploration mission sequences that allow humans to visit a wide number of inner solar system destinations were investigated. The scope of destinations included the Earth-Moon and Earth-Sun Lagrange points, near-Earth objects (NEOs), the Moon, and Mars and its moons. The missions examined assumed the use of Constellation Program elements along with existing launch vehicles and proposed augmentations. Additionally, robotic missions were envisioned as complements to human exploration through precursor missions, as crew emplaced scientific investigations, and as sample gathering assistants to the human crews. The focus of the flexible path approach was to gain ever-increasing operational experience through human exploration missions ranging from a few weeks to several years in duration, beginning in deep space beyond LEO and evolving to landings on the Moon and eventually Mars.

E057: Renal Stone Risk Assessment During Space Flight: Assessment and Countermeasure Validation

NASA Technical Reports Server (NTRS)

Whitson, Peggy A.; Pietrzyk, Robert A.; Jones, Jeffrey A.; Sams, Clarence F.

2001-01-01

Exposure to the microgravity environment results in many metabolic and physiological changes to humans. Body fluid volumes, electrolyte levels, and bone and muscle undergo changes as the human body adapts to the weightless environment. Changes in the urinary biochemistry occur as early as flight day 3-4 in the short duration Shuttle crewmembers. Significant decreases were observed both in fluid intake and urinary output. Other significant changes were observed in the urinary pH, calcium, potassium and uric acid levels. During Shuttle missions, the risk of calcium oxalate stone formation increased early in the flight, continued at elevated levels throughout the flight and remained in the increased risk range on landing day. The calcium phosphate risk was significantly increased early in-flight and remained significantly elevated throughout the remainder of the mission. Results from the long duration Shuttle-Mir missions followed a similar trend. Most long duration crewmembers demonstrated increased urinary calcium levels despite lower dietary calcium intake. Fluid intake and urine volumes were significantly lower during the flight than during the preflight. The calcium oxalate risk was increased relative to the preflight levels during the early in-flight period and continued in the elevated risk range for the remainder of the space flight and through two weeks postflight. Calcium phosphate risk for these long duration crewmembers increased during flight and remained in the increased risk range throughout the flight and following landing. The complexity, expense and visibility of the human space program require that every effort be made to protect the health of the crewmembers and ensure the success of the mission. Results from our early investigations clearly indicate that exposure to the microgravity environment of space significantly increases the risk of renal stone formation. The early studies have indicated specific avenues for development of countermeasures for the increased renal stone risk observed during and following space flight. Increased hydration and implementation of pharmacological countermeasures are being tested for their efficacy in mitigating the in-flight risk of renal stones. Maintaining the health and well-being of crewmembers during space flight requires a means of minimizing potential detrimental health effects of microgravity. The formation of a renal stone during flight obviously has severe consequences for the affected crewmember as well as the success of the mission.

Human tolerance to space flight

NASA Technical Reports Server (NTRS)

Huntoon, C. L.

1989-01-01

Medical studies of astronauts and cosmonauts before, during, and after space missions have identified several effects of weightlessness and other factors that influence the ability of humans to tolerate space flight. Weightlessness effects include space motion sickness, cardiovascular abnormalities, reduction in immune system function, loss of red blood cells, loss of bone mass, and muscle atrophy. Extravehicular activity (EVA) increases the likelihood that decompression sickness may occur. Radiation also gives reason for concern about health of crewmembers, and psychological factors are important on long-term flights. Countermeasures that have been used include sensory preadaptation, prebreathing and use of various air mixtures for EVA, loading with water and electrolytes, exercise, use of pharmacological agents and special diets, and psychological support. It appears that humans can tolerate and recover satisfactorily from at least one year of space flight, but a number of conditions must be further ameliorated before long-duration missions can be considered routine.

Interplanetary Transit Simulations Using the International Space Station

NASA Technical Reports Server (NTRS)

Charles, J. B.; Arya, Maneesh

2010-01-01

It has been suggested that the International Space Station (ISS) be utilized to simulate the transit portion of long-duration missions to Mars and near-Earth asteroids (NEA). The ISS offers a unique environment for such simulations, providing researchers with a high-fidelity platform to study, enhance, and validate technologies and countermeasures for these long-duration missions. From a space life sciences perspective, two major categories of human research activities have been identified that will harness the various capabilities of the ISS during the proposed simulations. The first category includes studies that require the use of the ISS, typically because of the need for prolonged weightlessness. The ISS is currently the only available platform capable of providing researchers with access to a weightless environment over an extended duration. In addition, the ISS offers high fidelity for other fundamental space environmental factors, such as isolation, distance, and accessibility. The second category includes studies that do not require use of the ISS in the strictest sense, but can exploit its use to maximize their scientific return more efficiently and productively than in ground-based simulations. In addition to conducting Mars and NEA simulations on the ISS, increasing the current increment duration on the ISS from 6 months to a longer duration will provide opportunities for enhanced and focused research relevant to long-duration Mars and NEA missions. Although it is currently believed that increasing the ISS crew increment duration to 9 or even 12 months will pose little additional risk to crewmembers, additional medical monitoring capabilities may be required beyond those currently used for the ISS operations. The use of the ISS to simulate aspects of Mars and NEA missions seems practical, and it is recommended that planning begin soon, in close consultation with all international partners.

Human Support Issues and Systems for the Space Exploration Initiative: Results from Project Outreach

DTIC Science & Technology

1991-01-01

that human factors were responsible for mission failure more often than equipment factors. Spacecraft habitability and ergonomics also require more...substantial challenges for designing reliable, flexible joints and dexterous, reliable gloves. Submission #100701 dealt with the ergonomics of work...perception that human factors deals primarily with cockpit displays and ergonomics . The success of long-duration missions will be highly dependent on

The future of space medicine.

PubMed

Nicogossian, A; Pober, D

2001-01-01

In November 2000, the National Aeronautics and Space Administration (NASA) and its partners in the International Space Station (ISS) ushered in a new era of space flight: permanent human presence in low-Earth orbit. As the culmination of the last four decades of human space flight activities. the ISS focuses our attention on what we have learned to date. and what still must be learned before we can embark on future exploration endeavors. Space medicine has been a primary part of our past success in human space flight, and will continue to play a critical role in future ventures. To prepare for the day when crews may leave low-Earth orbit for long-duration exploratory missions, space medicine practitioners must develop a thorough understanding of the effects of microgravity on the human body, as well as ways to limit or prevent them. In order to gain a complete understanding and create the tools and technologies needed to enable successful exploration. space medicine will become even more of a highly collaborative discipline. Future missions will require the partnership of physicians, biomedical scientists, engineers, and mission planners. This paper will examine the future of space medicine as it relates to human space exploration: what is necessary to keep a crew alive in space, how we do it today, how we will accomplish this in the future, and how the National Aeronautics and Space Administration (NASA) plans to achieve future goals.

Development of a Mars Environmental Control and Life Support System (ECLSS).

NASA Technical Reports Server (NTRS)

Henninger, Donald L.

2016-01-01

ECLS systems for very long-duration human missions to Mars will be designed to operate reliably for many years and will never be returned to Earth. The need for high reliability is driven by unsympathetic abort scenarios. Abort from a Mars mission could be as long as 450 days to return to Earth. Simply put, the goal of an ECLSS is to duplicate the functions the Earth provides in terms of human living and working on our home planet but without the benefit of the Earth's large buffers - the atmospheres, the oceans and land masses. With small buffers a space-based ECLSS must operate as a true dynamic system rather than independent processors taking things from tanks, processing them, and then returning them to product tanks. Key is a development process that allows for a logical sequence of validating successful development (maturation) in a stepwise manner with key performance parameters (KPPs) at each step; especially KPPs for technologies evaluated in a full systems context with human crews on Earth and on space platforms such as the ISS. This paper will explore the implications of such an approach to ECLSS development and the roles of ground and space-based testing necessary to develop a highly reliable life support system for long duration human exploration missions. Historical development and testing of ECLS systems from Mercury to the International Space Station (ISS) will be reviewed. Current work as well as recommendations for future work will be described.

Phase 1 research program overview

NASA Technical Reports Server (NTRS)

Uri, J. J.; Lebedev, O. N.

2001-01-01

The Phase 1 research program was unprecedented in its scope and ambitious in its objectives. The National Aeronautics and Space Administration committed to conducting a multidisciplinary long-duration research program on a platform whose capabilities were not well known, not to mention belonging to another country. For the United States, it provided the first opportunity to conduct research in a long-duration space flight environment since the Skylab program in the 1970's. Multiple technical as well as cultural challenges were successfully overcome through the dedicated efforts of a relatively small cadre of individuals. The program developed processes to successfully plan, train for and execute research in a long-duration environment, with significant differences identified from short-duration space flight science operations. Between August 1994 and June 1998, thousands of kilograms of research hardware was prepared and launched to Mir, and thousands of kilograms of hardware and data products were returned to Earth. More than 150 Principal Investigators from eight countries were involved in the program in seven major research disciplines: Advanced Technology; Earth Sciences; Fundamental Biology; Human Life Sciences; International Space Station Risk Mitigation; Microgravity; and Space Sciences. Approximately 75 long-duration investigations were completed on Mir, with additional investigations performed on the Shuttle flights that docked with Mir. The flight phase included the participation of seven US astronauts and 20 Russian cosmonauts. The successful completion of the Phase 1 research program not only resulted in high quality science return but also in numerous lessons learned to make the ISS experience more productive. The cooperation developed during the program was instrumental in its success. c2001 AIAA. Published by Elsevier Science Ltd.

Phase 1 research program overview.

PubMed

Uri, J J; Lebedev, O N

2001-01-01

The Phase 1 research program was unprecedented in its scope and ambitious in its objectives. The National Aeronautics and Space Administration committed to conducting a multidisciplinary long-duration research program on a platform whose capabilities were not well known, not to mention belonging to another country. For the United States, it provided the first opportunity to conduct research in a long-duration space flight environment since the Skylab program in the 1970's. Multiple technical as well as cultural challenges were successfully overcome through the dedicated efforts of a relatively small cadre of individuals. The program developed processes to successfully plan, train for and execute research in a long-duration environment, with significant differences identified from short-duration space flight science operations. Between August 1994 and June 1998, thousands of kilograms of research hardware was prepared and launched to Mir, and thousands of kilograms of hardware and data products were returned to Earth. More than 150 Principal Investigators from eight countries were involved in the program in seven major research disciplines: Advanced Technology; Earth Sciences; Fundamental Biology; Human Life Sciences; International Space Station Risk Mitigation; Microgravity; and Space Sciences. Approximately 75 long-duration investigations were completed on Mir, with additional investigations performed on the Shuttle flights that docked with Mir. The flight phase included the participation of seven US astronauts and 20 Russian cosmonauts. The successful completion of the Phase 1 research program not only resulted in high quality science return but also in numerous lessons learned to make the ISS experience more productive. The cooperation developed during the program was instrumental in its success. c2001 AIAA. Published by Elsevier Science Ltd.

Human Factors Engineering Requirements for the International Space Station - Successes and Challenges

NASA Technical Reports Server (NTRS)

Whitmore, M.; Blume, J.

2003-01-01

Advanced technology coupled with the desire to explore space has resulted in increasingly longer human space missions. Indeed, any exploration mission outside of Earth's neighborhood, in other words, beyond the moon, will necessarily be several months or even years. The International Space Station (ISS) serves as an important advancement toward executing a successful human space mission that is longer than a standard trip around the world or to the moon. The ISS, which is a permanently occupied microgravity research facility orbiting the earth, will support missions four to six months in duration. In planning for the ISS, the NASA developed an agency-wide set of human factors standards for the first time in a space exploration program. The Man-Systems Integration Standard (MSIS), NASA-STD-3000, a multi-volume set of guidelines for human-centered design in microgravity, was developed with the cooperation of human factors experts from various NASA centers, industry, academia, and other government agencies. The ISS program formed a human factors team analogous to any major engineering subsystem. This team develops and maintains the human factors requirements regarding end-to-end architecture design and performance, hardware and software design requirements, and test and verification requirements. It is also responsible for providing program integration across all of the larger scale elements, smaller scale hardware, and international partners.

Accomplishments in bioastronautics research aboard International Space Station.

PubMed

Uri, John J; Haven, Cynthia P

2005-01-01

The tenth long-duration expedition crew is currently in residence aboard International Space Station (ISS), continuing a permanent human presence in space that began in October 2000. During that time, expedition crews have been operators and subjects for 18 Human Life Sciences investigations, to gain a better understanding of the effects of long-duration spaceflight on the crewmembers and of the environment in which they live. Investigations have been conducted to study: the radiation environment in the station as well as during extravehicular activity (EVA); bone demineralization and muscle deconditioning; changes in neuromuscular reflexes; muscle forces and postflight mobility; causes and possible treatment of postflight orthostatic intolerance; risk of developing kidney stones; changes in pulmonary function caused by long-duration flight as well as EVA; crew and crew-ground interactions; changes in immune function, and evaluation of imaging techniques. The experiment mix has included some conducted in flight aboard ISS as well as several which collected data only pre- and postflight. The conduct of these investigations has been facilitated by the Human Research Facility (HRF). HRF Rack 1 became the first research rack on ISS when it was installed in the US laboratory module Destiny in March 2001. The rack provides a core set of experiment hardware to support investigations, as well as power, data and commanding capability, and stowage. The second HRF rack, to complement the first with additional hardware and stowage capability, will be launched once Shuttle flights resume. Future years will see additional capability to conduct human research on ISS as International Partner modules and facility racks are added to ISS. Crew availability, both as a subject count and time, will remain a major challenge to maximizing the science return from the bioastronautics research program. c2005 Published by Elsevier Ltd.

Developing Advanced Human Support Technologies for Planetary Exploration Missions

NASA Technical Reports Server (NTRS)

Berdich, Debra P.; Campbell, Paul D.; Jernigan, J. Mark

2004-01-01

The United States Vision for Space Exploration calls for sending robots and humans to explore the Earth's moon, the planet Mars, and beyond. The National Aeronautics and Space Administration (NASA) is developing a set of design reference missions that will provide further detail to these plans. Lunar missions are expected to provide a stepping stone, through operational research and evaluation, in developing the knowledge base necessary to send crews on long duration missions to Mars and other distant destinations. The NASA Exploration Systems Directorate (ExSD), in its program of bioastronautics research, manages the development of technologies that maintain human life, health, and performance in space. Using a system engineering process and risk management methods, ExSD's Human Support Systems (HSS) Program selects and performs research and technology development in several critical areas and transfers the results of its efforts to NASA exploration mission/systems development programs in the form of developed technologies and new knowledge about the capabilities and constraints of systems required to support human existence beyond Low Earth Orbit. HSS efforts include the areas of advanced environmental monitoring and control, extravehicular activity, food technologies, life support systems, space human factors engineering, and systems integration of all these elements. The HSS Program provides a structured set of deliverable products to meet the needs of exploration programs. These products reduce the gaps that exist in our knowledge of and capabilities for human support for long duration, remote space missions. They also reduce the performance gap between the efficiency of current space systems and the greater efficiency that must be achieved to make human planetary exploration missions economically and logistically feasible. In conducting this research and technology development program, it is necessary for HSS technologists and program managers to develop a common currency for decision making and the allocation of funding. A high level assessment is made of both the knowledge gaps and the system performance gaps across the program s technical project portfolio. This allows decision making that assures proper emphasis areas and provides a key measure of annual technological progress, as exploration mission plans continue to mature.

Risk of Adverse Health Outcomes & Decrements in Performance due to Inflight Medical Conditions: ExMC Pharmacy Research Plan

NASA Technical Reports Server (NTRS)

Antonsen, Erik

2016-01-01

The Exploration Medical Capabilities (ExMC) Element of NASA's Human Research Program is charged with identifying medical capabilities that can address the challenges of prevention, diagnosis, and treatment of disease and injuries that could occur during exploration missions beyond Earth's orbit. Faced with the obstacle of access to in-flight medical care, and limitations of vehicle space, time, and communications; it is necessary to prioritize what medical consumables are manifested for the flight, and which medical conditions are addressed. Studies of astronaut health establish the incidence of common and high risk medical conditions that require medical intervention during long-duration exploration missions. In 2000, the Institute of Medicine (IOM) convened a committee of experts, Committee on Creating a Vision for Space Medicine during Travel beyond Earth Orbit, to examine the issues surrounding astronaut health and safety for long duration space missions. Two themes run throughout the committee's final report: (1) that not enough is known about the risks to human health during long-duration missions beyond Earth's orbit or about what can effectively mitigate those risks to enable humans to travel and work safely in the environment of deep space and (2) that everything reasonable should be done to gain the necessary information before humans are sent on missions of space exploration (IOM, 2001). Although several spaceflight focused pharmaceutical research studies have been conducted, few have provided sufficient data regarding medication usage or potency changes during spaceflight. The Du pharmaceutical stability study assessed medications flown on space shuttles to and from the International Space Station (ISS) from 2006 until 2008; of which some medications were still viable beyond their expiration dates (Du et al, 2011). However, as with many spaceflight studies, the small 'n' associated with this study limits the ability to draw strong conclusions from it. Dr. Wotring and others have recently published articles containing information regarding medication usage, indications, and efficacy gleaned from spaceflight records (Wotring et al, 2015, 2016; Barger et al, 2014; Basner and Dinges, 2014). Although some conclusions can be drawn from these studies, the inability to fully quantify medication usage, indications, side effects, and effectiveness, limits insight as to which medications should be prioritized for further research.

Promoting Crew Autonomy: Current Advances and Novel Techniques

NASA Technical Reports Server (NTRS)

Harris, Samantha

2017-01-01

Since the dawn of the era of human space flight, mission control centers around the world have played an integral role in guiding space travelers toward mission success. In the International Space Station (ISS) program, astronauts and cosmonauts have the benefit of near constant access to the expertise and resources within mission control, as well as lifeboat capability to quickly return to Earth if something were to go wrong. As we move into an era of longer duration missions to more remote locations, rapid and ready access to mission control on earth will no longer be feasible. To prepare for such missions, long duration crews must be prepared to operate more autonomously, and the mission control paradigm that has been successfully employed for decades must be re-examined. The team at NASA's Payload Operations and Integration Center (POIC) in Huntsville, Alabama is playing an integral role in the development of concepts for a more autonomous long duration crew of the future via research on the ISS.

Optimization of Brain T2 Mapping Using Standard CPMG Sequence In A Clinical Scanner

NASA Astrophysics Data System (ADS)

Hnilicová, P.; Bittšanský, M.; Dobrota, D.

2014-04-01

In magnetic resonance imaging, transverse relaxation time (T2) mapping is a useful quantitative tool enabling enhanced diagnostics of many brain pathologies. The aim of our study was to test the influence of different sequence parameters on calculated T2 values, including multi-slice measurements, slice position, interslice gap, echo spacing, and pulse duration. Measurements were performed using standard multi-slice multi-echo CPMG imaging sequence on a 1.5 Tesla routine whole body MR scanner. We used multiple phantoms with different agarose concentrations (0 % to 4 %) and verified the results on a healthy volunteer. It appeared that neither the pulse duration, the size of interslice gap nor the slice shift had any impact on the T2. The measurement accuracy was increased with shorter echo spacing. Standard multi-slice multi-echo CPMG protocol with the shortest echo spacing, also the smallest available interslice gap (100 % of slice thickness) and shorter pulse duration was found to be optimal and reliable for calculating T2 maps in the human brain.

Psychology and culture during long-duration space missions

NASA Astrophysics Data System (ADS)

Kanas, N.; Sandal, G.; Boyd, J. E.; Gushin, V. I.; Manzey, D.; North, R.; Leon, G. R.; Suedfeld, P.; Bishop, S.; Fiedler, E. R.; Inoue, N.; Johannes, B.; Kealey, D. J.; Kraft, N.; Matsuzaki, I.; Musson, D.; Palinkas, L. A.; Salnitskiy, V. P.; Sipes, W.; Stuster, J.; Wang, J.

2009-04-01

The objective of this paper is twofold: (a) to review the current knowledge of cultural, psychological, psychiatric, cognitive, interpersonal, and organizational issues that are relevant to the behavior and performance of astronaut crews and ground support personnel and (b) to make recommendations for future human space missions, including both transit and planetary surface operations involving the Moon or Mars. The focus will be on long-duration missions lasting at least six weeks, when important psychological and interpersonal factors begin to take their toll on crewmembers. This information is designed to provide guidelines for astronaut selection and training, in-flight monitoring and support, and post-flight recovery and re-adaptation.

Locomotor exercise in weightlessness

NASA Technical Reports Server (NTRS)

Thornton, W.; Whitmore, H.

1991-01-01

The requirements for exercise in space by means of locomotion are established and addressed with prototype treadmills for use during long-duration spaceflight. The adaptation of the human body to microgravity is described in terms of 1-G locomotor biomechanics, the effects of reduced activity, and effective activity-replacement techniques. The treadmill is introduced as a complement to other techniques of force replacement with reference given to the angle required for exercise. A motor-driven unit is proposed that can operate at a variety of controlled speeds and equivalent grades. The treadmills permit locomotor exercise as required for long-duration space travel to sustain locomotor and cardiorespiratory capacity at a level consistent with postflight needs.

Main medical results of extended flights on space station Mir in 1986-1990

NASA Astrophysics Data System (ADS)

Grigoriev, A. I.; Bugrov, S. A.; Bogomolov, V. V.; Egorov, A. D.; Polyakov, V. V.; Tarasov, I. K.; Shulzhenko, E. B.

During 1986-1990 seven prime spacecrews (16 cosmonauts) have flow on-board the Mir orbital complex. The longest space mission duration was 366 days. The principal objectives of the medical tasks were the maintenance of good health and performance of the spacecrews and conducting medical research programs which included study of the cardiovascular, motor, endocrine, blood, immune, and metabolic systems. Results obtained point to the ability of humans to readily adapt to a year-long stay in space and maintain good health and performance. Readaptation had a similar course as after other previous long-term space flights of up to 8 months in duration. Primary body system changes were not qualitatively different from findings after flights aboard the Salyut 6 and 7 space stations. In this case, during and after an 11-12 month flight, body system alterations were even less severe which was a result of adequate countermeasure use, their systematic and creative employment and maintenance of required environments to support life and work in space.

Cytogenetic damage in the blood lymphocytes of astronauts: effects of repeat long-duration space missions.

PubMed

George, K; Rhone, J; Beitman, A; Cucinotta, F A

2013-08-30

Human missions onboard the International Space Station (ISS) are increasing in duration and several astronauts have now participated in second ISS increments. The radiation environment in space is very different from terrestrial radiation exposure and it is still unclear if space flight effects and radiation from repeat missions are simply additive, which potentially confounds the assessment of the cumulative risk of radiation exposure. It has been shown that single space missions of a few months or more on the ISS can induce measureable increases in the yield of chromosome damage in the blood lymphocytes of astronauts, and it appears that cytogenetic biodosimetry can be used reliably to estimate equivalent dose and radiation risk. We have now obtained direct in vivo measurements of chromosome damage in blood lymphocytes of five astronauts before and after their first and second long duration space flights. Chromosome damage was assessed by fluorescence in situ hybridization technique using three different chromosome painting probes. All astronauts showed an increase in total exchanges and translocations after both the first and second flight. Biological dose measured using either individual assessment or a population assessment supports an additive risk model. Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.

Effects of sex and gender on adaptations to space: reproductive health.

PubMed

Ronca, April E; Baker, Ellen S; Bavendam, Tamara G; Beck, Kevin D; Miller, Virginia M; Tash, Joseph S; Jenkins, Marjorie

2014-11-01

In this report, sex/gender research relevant to reproduction on Earth, in conjunction with the extant human and animal observations in space, was used to identify knowledge gaps and prioritize recommendations for future sex- and gender-specific surveillance and monitoring of male and female astronauts. With overall increased durations of contemporary space missions, a deeper understanding of sex/gender effects on reproduction-related responses and adaptations to the space environment is warranted to minimize risks and insure healthy aging of the men and women who travel into space.

Effects of Sex and Gender on Adaptations to Space: Reproductive Health

PubMed Central

Baker, Ellen S.; Bavendam, Tamara G.; Beck, Kevin D.; Miller, Virginia M.; Tash, Joseph S.; Jenkins, Marjorie

2014-01-01

Abstract In this report, sex/gender research relevant to reproduction on Earth, in conjunction with the extant human and animal observations in space, was used to identify knowledge gaps and prioritize recommendations for future sex- and gender-specific surveillance and monitoring of male and female astronauts. With overall increased durations of contemporary space missions, a deeper understanding of sex/gender effects on reproduction-related responses and adaptations to the space environment is warranted to minimize risks and insure healthy aging of the men and women who travel into space. PMID:25401943

Life sciences - On the critical path for missions of exploration

NASA Technical Reports Server (NTRS)

Sulzman, Frank M.; Connors, Mary M.; Gaiser, Karen

1988-01-01

Life sciences are important and critical to the safety and success of manned and long-duration space missions. The life science issues covered include gravitational physiology, space radiation, medical care delivery, environmental maintenance, bioregenerative systems, crew and human factors within and outside the spacecraft. The history of the role of life sciences in the space program is traced from the Apollo era, through the Skylab era to the Space Shuttle era. The life science issues of the space station program and manned missions to the moon and Mars are covered.

Development of task network models of human performance in microgravity

NASA Technical Reports Server (NTRS)

Diaz, Manuel F.; Adam, Susan

1992-01-01

This paper discusses the utility of task-network modeling for quantifying human performance variability in microgravity. The data are gathered for: (1) improving current methodologies for assessing human performance and workload in the operational space environment; (2) developing tools for assessing alternative system designs; and (3) developing an integrated set of methodologies for the evaluation of performance degradation during extended duration spaceflight. The evaluation entailed an analysis of the Remote Manipulator System payload-grapple task performed on many shuttle missions. Task-network modeling can be used as a tool for assessing and enhancing human performance in man-machine systems, particularly for modeling long-duration manned spaceflight. Task-network modeling can be directed toward improving system efficiency by increasing the understanding of basic capabilities of the human component in the system and the factors that influence these capabilities.

Space Exploration: Where We Have Been, Where We Are and Where We Are Going: A Human Perspective

NASA Technical Reports Server (NTRS)

Tripathi, R. K.

2005-01-01

NASA is moving forward towards the agency's new vision for space exploration in the 21st Century encompassing a broad range of human and robotic missions including missions to Moon, Mars and beyond. Exposure from the hazards of severe space radiation in deep space long duration missions is the show stopper. Langley has developed state-of-the-art radiation protection and shielding technology for space missions. The payload penalty demands a very stringent requirement on the design of the spacecrafts for human deep space missions. The exploration beyond low Earth orbit (LEO) to enable routine access to more interesting regions of space will require protection from the hazards of the accumulated exposures of space radiation, Galactic Cosmic Rays (GCR) and Solar Particle Events (SPE), and minimizing the production of secondary radiation is a great advantage. The better understanding of radiation environment (GCR & SPE) and their interaction is a key to the success of the program due to the vital role and importance of cosmic rays for space missions.

Radiation Environments for Future Human Exploration Throughout the Solar System.

NASA Astrophysics Data System (ADS)

Schwadron, N.; Gorby, M.; Linker, J.; Riley, P.; Torok, T.; Downs, C.; Spence, H. E.; Desai, M. I.; Mikic, Z.; Joyce, C. J.; Kozarev, K. A.; Townsend, L. W.; Wimmer-Schweingruber, R. F.

2016-12-01

Acute space radiation hazards pose one of the most serious risks to future human and robotic exploration. The ability to predict when and where large events will occur is necessary in order to mitigate their hazards. The largest events are usually associated with complex sunspot groups (also known as active regions) that harbor strong, stressed magnetic fields. Highly energetic protons accelerated very low in the corona by the passage of coronal mass ejection (CME)-driven compressions or shocks and from flares travel near the speed of light, arriving at Earth minutes after the eruptive event. Whether these particles actually reach Earth, the Moon, Mars (or any other point) depends on their transport in the interplanetary magnetic field and their magnetic connection to the shock. Recent contemporaneous observations during the largest events in almost a decade show the unique longitudinal distributions of this ionizing radiation broadly distributed from sources near the Sun and yet highly isolated during the passage of CME shocks. Over the last decade, we have observed space weather events as the solar wind exhibits extremely low densities and magnetic field strengths, representing states that have never been observed during the space age. The highly abnormal solar activity during cycles 23 and 24 has caused the longest solar minimum in over 80 years and continues into the unusually small solar maximum of cycle 24. As a result of the remarkably weak solar activity, we have also observed the highest fluxes of galactic cosmic rays in the space age and relatively small particle radiation events. We have used observations from LRO/CRaTER to examine the implications of these highly unusual solar conditions for human space exploration throughout the inner solar system. While these conditions are not a show-stopper for long-duration missions (e.g., to the Moon, an asteroid, or Mars), galactic cosmic ray radiation remains a significant and worsening factor that limits mission durations. If the heliospheric magnetic field continues to weaken over time, as is likely, then allowable mission durations will decrease correspondingly. Thus, we examine the rapidly changing radiation environment and its implications for human exploration destinations throughout the inner solar system.

Exploration-Related Research on the International Space Station: Connecting Science Results to the Design of Future Missions

NASA Technical Reports Server (NTRS)

Rhatigan, Jennifer L.; Robinson, Julie A.; Sawin, Charles F.; Ahlf, Peter R.

2005-01-01

In January, 2004, the US President announced a vision for space exploration, and charged NASA with utilizing the International Space Station (ISS) for research and technology targeted at supporting the US space exploration goals. This paper describes: 1) what we have learned from the first four years of research on ISS relative to the exploration mission, 2) the on-going research being conducted in this regard, 3) our current understanding of the major exploration mission risks that the ISS can be used to address, and 4) current progress in realigning NASA s research portfolio for ISS to support exploration missions. Specifically, we discuss the focus of research on solving the perplexing problems of maintaining human health on long-duration missions, and the development of countermeasures to protect humans from the space environment, enabling long duration exploration missions. The interchange between mission design and research needs is dynamic, where design decisions influence the type of research needed, and results of research influence design decisions. The fundamental challenge to science on ISS is completing experiments that answer key questions in time to shape design decisions for future exploration. In this context, exploration-relevant research must do more than be conceptually connected to design decisions-it must become a part of the mission design process.

Aerospace nursing: the new frontier.

PubMed

Polk-Walker, G C

1989-01-01

Since the days of Florence Nightingale and the Crimean War, nursing has been involved in shaping the environment to make it more conducive to human existence. With the emergence of the Space Age the environment has broadened to encompass not only Earth and its ionosphere, but its moon and sister planets as well. To date, nursing has been successful in developing theories that address human-environmental interactions. However, the environment of the 21st century will be vastly different from the environment of the 1980s. In the 21st century, macroutilization of space will become a reality. Such broad-based use of space will include space industrialization and manufacturing, satellite solar power generation, and space habitation. In order to achieve long-duration space flights and habitation, human needs and responses to microgravity must be addressed. This article discusses the physiological and psychological stresses that have an impact on the ability of humans to achieve space habitation and nursing's role in that endeavor. The nursing knowledge base needed to establish the discipline as a major contributor to space health science is discussed. An educational strategy for the development of this knowledge at both the master's and doctoral levels is proposed.

The International Space Station Habitat

NASA Technical Reports Server (NTRS)

Watson, Patricia Mendoza; Engle, Mike

2003-01-01

The International Space Station (ISS) is an engineering project unlike any other. The vehicle is inhabited and operational as construction goes on. The habitability resources available to the crew are the crew sleep quarters, the galley, the waste and hygiene compartment, and exercise equipment. These items are mainly in the Russian Service Module and their placement is awkward for the crew to deal with ISS assembly will continue with the truss build and the addition of International Partner Laboratories. Also, Node 2 and 3 will be added. The Node 2 module will provide additional stowage volume and room for more crew sleep quarters. The Node 3 module will provide additional Environmental Control and Life Support Capability. The purpose of the ISS is to perform research and a major area of emphasis is the effects of long duration space flight on humans, a result of this research they will determine what are the habitability requirements for long duration space flight.

Developing Advanced Support Technologies for Planetary Exploration Missions

NASA Technical Reports Server (NTRS)

Berdich, Debra P.; Campbel, Paul D.; Jernigan, J. Mark

2004-01-01

The United States Vision for Space Exploration calls for sending robots and humans to explore the Earth s moon, the planet Mars, and beyond. The National Aeronautics and Space Administration (NASA) is developing a set of design reference missions that will provide further detail to these plans. Lunar missions are expected to provide a stepping stone, through operational research and evaluation, in developing the knowledge base necessary to send crews on long duration missions to Mars and other distant destinations. The NASA Exploration Systems Directorate (ExSD), in its program of bioastronautics research, manages the development of technologies that maintain human life, health, and performance in space. Using a systems engineering process and risk management methods, ExSD s Human Support Systems (HSS) Program selects and performs research and technology development in several critical areas and transfers the results of its efforts to NASA exploration mission/systems development programs in the form of developed technologies and new knowledge about the capabilities and constraints of systems required to support human existence beyond Low Earth Orbit. HSS efforts include the areas of advanced environmental monitoring and control, extravehicular activity, food technologies, life support systems, space human factors engineering, and systems integration of all these elements. The HSS Program provides a structured set of deliverable products to meet the needs of exploration programs. these products reduce the gaps that exist in our knowledge of and capabilities for human support for long duration, remote space missions. They also reduce the performance gap between the efficiency of current space systems and the greater efficiency that must be achieved to make human planetary exploration missions economically and logistically feasible. In conducting this research and technology development program, it is necessary for HSS technologists and program managers to develop a common currency for decision making and the allocation of funding. A high level assessment is made of both the knowledge gaps and the system performance gaps across the program s technical project portfolio. This allows decision making that assures proper emphasis areas and provides a key measure of annual technological progress, as exploration mission plans continue to mature.

Habitats and Surface Construction Technology and Development Roadmap

NASA Technical Reports Server (NTRS)

Cohen, Marc; Kennedy, Kriss J.

1997-01-01

The vision of the technology and development teams at NASA Ames and Johnson Research Centers is to provide the capability for automated delivery and emplacement of habitats and surface facilities. The benefits of the program are as follows: Composites and Inflatables: 30-50% (goal) lighter than Al Hard Structures; Capability for Increased Habitable Volume, Launch Efficiency; Long Term Growth Potential; and Supports initiation of commercial and industrial expansion. Key Habitats and Surface Construction (H&SC) technology issues are: Habitat Shell Structural Materials; Seals and Mechanisms; Construction and Assembly: Automated Pro-Deploy Construction Systems; ISRU Soil/Construction Equipment: Lightweight and Lower Power Needs; Radiation Protection (Health and Human Performance Tech.); Life Support System (Regenerative Life Support System Tech.); Human Physiology of Long Duration Space Flight (Health and Human Performance Tech.); and Human Psychology of Long Duration Space Flight (Health and Human Performance Tech.) What is being done regarding these issues?: Use of composite materials for X-38 CRV, RLV, etc.; TransHAB inflatable habitat design/development; Japanese corporations working on ISRU-derived construction processes. What needs to be done for the 2004 Go Decision?: Characterize Mars Environmental Conditions: Civil Engineering, Material Durability, etc.; Determine Credibility of Inflatable Structures for Human Habitation; and Determine Seal Technology for Mechanisms and Hatches, Life Cycle, and Durability. An overview encompassing all of the issues above is presented.

Robotics for Human Exploration

NASA Technical Reports Server (NTRS)

Fong, Terrence; Deans, Mathew; Bualat, Maria

2013-01-01

Robots can do a variety of work to increase the productivity of human explorers. Robots can perform tasks that are tedious, highly repetitive or long-duration. Robots can perform precursor tasks, such as reconnaissance, which help prepare for future human activity. Robots can work in support of astronauts, assisting or performing tasks in parallel. Robots can also perform "follow-up" work, completing tasks designated or started by humans. In this paper, we summarize the development and testing of robots designed to improve future human exploration of space.

International Space Station as Analog of Interplanetary Transit Vehicle For Biomedical Research

NASA Technical Reports Server (NTRS)

Charles, John B.

2012-01-01

Astronaut missions lasting up to six months aboard the International Space Station (ISS) have much in common with interplanetary flights, especially the outbound, Earth-to-Mars transit portion of a Mars mission. Utilization of ISS and other appropriate platforms to prepare for crewed expeditions to planetary destinations including Mars has been the work of NASA's Human Research Program (HRP) since 2005. HRP is charged specifically to understand and reduced the risks to astronaut health and performance in space exploration missions: everything HRP does and has done is directly related to that responsibility. Two major categories of human research have capitalized on ISS capabilities. The first category centers on the biomedical aspects of long-duration exposure to spaceflight factors, including prolonged weightlessness, radiation exposure, isolation and confinement, and actual risk to life and limb. These studies contribute to astronaut safety, health and efficiency on any long-duration missions, whether in low Earth orbit (LEO) or beyond. Qualitatively, weightlessness is weightlessness, whether in LEO or en route to Mars. The HRP sponsors investigations into losses in muscle and bone integrity, cardiovascular function, sensory-motor capability, immune capacity and psychosocial health, and development and demonstration of appropriate treatments and preventative measures. The second category includes studies that are focused on planetary expeditions beyond LEO. For these, ISS offers a high fidelity analog to investigate the combined effects of spaceflight factors (described above) plus the isolation and autonomy associated with simulated increasing distance from Earth. Investigations address crew cohesion, performance and workload, and mission control performance. The behavioral health and performance and space human factors aspects of planetary missions dominate this category. Work has already begun on a new investigation in this category which will examine the effects of a simulated lag in communications (mimicking that expected in transit to Mars) on astronaut performance aboard ISS. Extension of the current ISS increment duration from six months to nine or even twelve months would provide opportunities for expanded research relevant to long duration missions, albeit at the cost of fewer astronauts as subjects for those investigations. Given the possible limited access to ISS after 2020, if ISS is intended to facilitate future exploration missions, then the in-flight human investigations should focus on those that clearly enable future exploration missions.

Spacecraft Habitable Volume: Results of an Interdisciplinary Workshop

NASA Technical Reports Server (NTRS)

Fitts, David J.; Connolly, Janis; Howard, Robert

2011-01-01

NASA's Human Exploration Framework Team posed the question: "Is 80 cubic meters per person of habitable volume acceptable for a proposed Deep Space Habitat?" The goal of the workshop was to address the "net habitable volume" necessary for long-duration human spaceflight missions and identify design and psychological issues and mitigations. The objectives were: (1) Identify psychological factors -- i.e., "stressors" -- that impact volume and layout specifications for long duration missions (2) Identify mitigation strategies for stressors, especially those that can be written as volume design specifications (3) Identify a forward research roadmap -- i.e., what future work is needed to define and validate objective design metrics? (4) Provide advisories on the human factors consequences of poor net habitable volume allocation and layout design.

Independent coding of absolute duration and distance magnitudes in the prefrontal cortex

PubMed Central

Marcos, Encarni; Tsujimoto, Satoshi

2016-01-01

The estimation of space and time can interfere with each other, and neuroimaging studies have shown overlapping activation in the parietal and prefrontal cortical areas. We used duration and distance discrimination tasks to determine whether space and time share resources in prefrontal cortex (PF) neurons. Monkeys were required to report which of two stimuli, a red circle or blue square, presented sequentially, were longer and farther, respectively, in the duration and distance tasks. In a previous study, we showed that relative duration and distance are coded by different populations of neurons and that the only common representation is related to goal coding. Here, we examined the coding of absolute duration and distance. Our results support a model of independent coding of absolute duration and distance metrics by demonstrating that not only relative magnitude but also absolute magnitude are independently coded in the PF. NEW & NOTEWORTHY Human behavioral studies have shown that spatial and duration judgments can interfere with each other. We investigated the neural representation of such magnitudes in the prefrontal cortex. We found that the two magnitudes are independently coded by prefrontal neurons. We suggest that the interference among magnitude judgments might depend on the goal rather than the perceptual resource sharing. PMID:27760814

Applying lessons learned to enhance human performance and reduce human error for ISS operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, W.R.

1999-01-01

A major component of reliability, safety, and mission success for space missions is ensuring that the humans involved (flight crew, ground crew, mission control, etc.) perform their tasks and functions as required. This includes compliance with training and procedures during normal conditions, and successful compensation when malfunctions or unexpected conditions occur. A very significant issue that affects human performance in space flight is human error. Human errors can invalidate carefully designed equipment and procedures. If certain errors combine with equipment failures or design flaws, mission failure or loss of life can occur. The control of human error during operation ofmore » the International Space Station (ISS) will be critical to the overall success of the program. As experience from Mir operations has shown, human performance plays a vital role in the success or failure of long duration space missions. The Department of Energy{close_quote}s Idaho National Engineering and Environmental Laboratory (INEEL) is developing a systematic approach to enhance human performance and reduce human errors for ISS operations. This approach is based on the systematic identification and evaluation of lessons learned from past space missions such as Mir to enhance the design and operation of ISS. This paper will describe previous INEEL research on human error sponsored by NASA and how it can be applied to enhance human reliability for ISS. {copyright} {ital 1999 American Institute of Physics.}« less

Applying lessons learned to enhance human performance and reduce human error for ISS operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, W.R.

1998-09-01

A major component of reliability, safety, and mission success for space missions is ensuring that the humans involved (flight crew, ground crew, mission control, etc.) perform their tasks and functions as required. This includes compliance with training and procedures during normal conditions, and successful compensation when malfunctions or unexpected conditions occur. A very significant issue that affects human performance in space flight is human error. Human errors can invalidate carefully designed equipment and procedures. If certain errors combine with equipment failures or design flaws, mission failure or loss of life can occur. The control of human error during operation ofmore » the International Space Station (ISS) will be critical to the overall success of the program. As experience from Mir operations has shown, human performance plays a vital role in the success or failure of long duration space missions. The Department of Energy`s Idaho National Engineering and Environmental Laboratory (INEEL) is developed a systematic approach to enhance human performance and reduce human errors for ISS operations. This approach is based on the systematic identification and evaluation of lessons learned from past space missions such as Mir to enhance the design and operation of ISS. This paper describes previous INEEL research on human error sponsored by NASA and how it can be applied to enhance human reliability for ISS.« less

Application of virtual reality for crew mental health in extended-duration space missions

NASA Astrophysics Data System (ADS)

Salamon, Nick; Grimm, Jonathan M.; Horack, John M.; Newton, Elizabeth K.

2018-05-01

Human exploration of the solar system brings a host of environmental and engineering challenges. Among the most important factors in crew health and human performance is the preservation of mental health. The mental well-being of astronaut crews is a significant issue affecting the success of long-duration space missions, such as habitation on or around the Moon, Mars exploration, and eventual colonization of the solar system. If mental health is not properly addressed, these missions will be at risk. Upkeep of mental health will be especially difficult on long duration missions because many of the support systems available to crews on shorter missions will not be available. In this paper, we examine the use of immersive virtual reality (VR) simulations to maintain healthy mental states in astronaut crews who are removed from the essential comforts typically associated with terrestrial life. Various methods of simulations and their administration are analyzed in the context of current research and knowledge in the fields of psychology, medicine, and space sciences, with a specific focus on the environment faced by astronauts on long-term missions. The results of this investigation show that virtual reality should be considered a plausible measure in preventing mental state deterioration in astronauts, though more work is needed to provide a comprehensive view of the effectiveness and administration of VR methods.

Human Research Program Integrated Research Plan: December 20, 2007, Interim Baseline

NASA Technical Reports Server (NTRS)

2008-01-01

The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. This Integrated Research Plan (IRP) describes the program s research activities that are intended to address the needs of human space exploration and serve HRP customers. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration. The document serves several purposes for the Human Research Program: The IRP provides a means to assure that the most significant risks to human space explorers are being adequately mitigated and/or addressed, The IRP shows the relationship of research activities to expected outcomes and need dates, The IRP shows the interrelationships among research activities that may interact to produce products that are integrative or cross defined research disciplines, The IRP illustrates the non-deterministic nature of research and technology activities by showing expected decision points and potential follow-on activities, The IRP shows the assignments of responsibility within the program organization and, as practical, the intended solicitation approach, The IRP shows the intended use of research platforms such as the International Space Station, NASA Space Radiation Laboratory, and various space flight analogs. The IRP does not show all budgeted activities of the Human research program, as some of these are enabling functions, such as management, facilities and infrastructure

U.S. view of human problems to be addressed for long duration space flights. [physiological and psychological effects

NASA Technical Reports Server (NTRS)

Berry, C. A.

1973-01-01

The Russian and American space programs have consisted of several thousands of hours of exposure of man to the space environment. In spite of numerous biological phenomena of adaptation observed, the space travellers have displayed, after their return, no enduring pathological effect. Although the usable data remain too limited to reflect fully the effects of space flight, it is possible to sketch the biological responses in the absence of gravity and to define the work bases for the future. Beyond its basic physiological effects, weightlessness has operational consequences in the daily life of the astronauts. These consequences will be still more evident during missions of long duration. The conclusions drawn in flight as well as on the ground are reviewed, and future requirements concerning prolonged flights are outlined. The gaps in actual knowledge are discussed and solutions are suggested. The problems of habitability are considered, particularly those which remain at present without satisfactory solutions: psychological responses to a confined life, cleaning, hygiene, and used material.

NUTRITION w/Repository

NASA Image and Video Library

2009-06-06

ISS020-E-007566 (6 June 2009) --- European Space Agency astronaut Frank De Winne, Expedition 20 flight engineer, prepares to put samples in the Minus Eighty Laboratory Freezer for ISS (MELFI) in the Kibo laboratory of the International Space Station. Samples were taken as part of the Nutritional Status Assessment (Nutrition) with Repository experiment, a study done by NASA to date of human physiologic changes during long-duration spaceflight.

Novel Exercise Hardware Requirements, Development, and Selection Process for Long-Duration Space Flight

NASA Technical Reports Server (NTRS)

Weaver, Aaron S.; Funk, Justin H.; Funk, Nathan W.; Dewitt, John K.; Fincke, Renita S.; Newby, Nathaniel; Caldwell, Erin; Sheehan, Christopher C.; Moore, E. Cherice; Ploutz-Snyder, Lori;

New Developments in NASA's Rodent Research Hardware for Conducting Long Duration Biomedical and Basic Research in Space

NASA Technical Reports Server (NTRS)

Shirazi, Yasaman; Choi, S.; Harris, C.; Gong, C.; Fisher, R. J.; Beegle, J. E.; Stube, K. C.; Martin, K. J.; Nevitt, R. G.; Globus, R. K.

2017-01-01

Animal models, particularly rodents, are the foundation of pre-clinical research to understand human diseases and evaluate new therapeutics, and play a key role in advancing biomedical discoveries both on Earth and in space. The National Research Councils Decadal survey emphasized the importance of expanding NASA's life sciences research to perform long duration, rodent experiments on the International Space Station (ISS) to study effects of the space environment on the musculoskeletal and neurological systems of mice as model organisms of human health and disease, particularly in areas of muscle atrophy, bone loss, and fracture healing. To accomplish this objective, flight hardware, operations, and science capabilities were developed at NASA Ames Research Center (ARC) to enhance science return for both commercial (CASIS) and government-sponsored rodent research. The Rodent Research Project at NASA ARC has pioneered a new research capability on the International Space Station and has progressed toward translating research to the ISS utilizing commercial rockets, collaborating with academia and science industry, while training crewmembers to assist in performing research on orbit. The Rodent Research Habitat provides a living environment for animals on ISS according to standard animal welfare requirements, and daily health checks can be performed using the habitats camera system. Results from these studies contribute to the science community via both the primary investigation and banked samples that are shared in publicly available data repository such as GeneLab. Following each flight, through the Biospecimen Sharing Program (BSP), numerous tissues and thousands of samples will be harvested, and distributed from the Space Life and Physical Sciences (SLPS) to Principal Investigators (PIs) through the Ames Life Science Data Archive (ALSDA). Every completed mission sets a foundation to build and design greater complexity into future research and answer questions about common human diseases. Together, the hardware improvements (enrichment, telemetry sensors, cameras), new capabilities (live animal return), and experience that the Rodent Research team has gained working with principal investigator teams and ISS crew to conduct complex experiments on orbit are expanding capabilities for long duration rodent research on the ISS to achieve both basic science and biomedical research objectives.

Making a home in space

NASA Technical Reports Server (NTRS)

Aaron, John; Gabris, Edward A.; Sulzman, Frank M.; Connors, Mary M.; Pilcher, Carl

1989-01-01

NASA's Office of Aeronautics and Space Technology has undertaken a series of manned space presence-development efforts under the aegis of the Civil Space Technology Initiative (CSTI) and Project Pathfinder. Typical of these CSTI efforts is the Aeroassist Flight Experiment, which will demonstrate techniques suitable in aerobrake design for slow trajectories to Mars and for lunar mission return. Long-duration human operations in space are a major element of Pathfinder, giving attention to such problems as space radiation exposure effects that could be several orders of magnitude greater on interplanetary exploration missions than on typical Space Shuttle flights. Mars Observer and Lunar Observer orbital missions are planned as a steppingstone to manned planetary exploration.

The hindlimb unloading rat model: literature overview, technique update and comparison with space flight data

NASA Technical Reports Server (NTRS)

Morey-Holton, Emily; Globus, Ruth K.; Kaplansky, Alexander; Durnova, Galina

2005-01-01

The hindlimb unloading rodent model is used extensively to study the response of many physiological systems to certain aspects of space flight, as well as to disuse and recovery from disuse for Earth benefits. This chapter describes the evolution of hindlimb unloading, and is divided into three sections. The first section examines the characteristics of 1064 articles using or reviewing the hindlimb unloading model, published between 1976 and April 1, 2004. The characteristics include number of publications, journals, countries, major physiological systems, method modifications, species, gender, genetic strains and ages of rodents, experiment duration, and countermeasures. The second section provides a comparison of results between space flown and hindlimb unloading animals from the 14-day Cosmos 2044 mission. The final section describes modifications to hindlimb unloading required by different experimental paradigms and a method to protect the tail harness for long duration studies. Hindlimb unloading in rodents has enabled improved understanding of the responses of the musculoskeletal, cardiovascular, immune, renal, neural, metabolic, and reproductive systems to unloading and/or to reloading on Earth with implications for both long-duration human space flight and disuse on Earth.

Bold endeavors: behavioral lessons from polar and space exploration

NASA Technical Reports Server (NTRS)

Stuster, J. W.

2000-01-01

Anecdotal comparisons frequently are made between expeditions of the past and space missions of the future. Spacecraft are far more complex than sailing ships, but from a psychological perspective, the differences are few between confinement in a small wooden ship locked in the polar ice cap and confinement in a small high-technology ship hurtling through interplanetary space. This paper discusses some of the behavioral lessons that can be learned from previous expeditions and applied to facilitate human adjustment and performance during future space expeditions of long duration.

[Research activities of cosmonauts in long-duration orbital missions].

PubMed

2012-01-01

The paper presents the view of space medicine and human factor experts on the problems of cosmonaut's research activities. Readiness of ISS crewmembers for conducting experiments and research equipment handling depends on the pre-flight training quality and course of adaptation to the flight conditions, the latter of particular criticality for participation in human use tests as an object.

Increased core body temperature in astronauts during long-duration space missions.

PubMed

Stahn, Alexander C; Werner, Andreas; Opatz, Oliver; Maggioni, Martina A; Steinach, Mathias; von Ahlefeld, Victoria Weller; Moore, Alan; Crucian, Brian E; Smith, Scott M; Zwart, Sara R; Schlabs, Thomas; Mendt, Stefan; Trippel, Tobias; Koralewski, Eberhard; Koch, Jochim; Choukèr, Alexander; Reitz, Günther; Shang, Peng; Röcker, Lothar; Kirsch, Karl A; Gunga, Hanns-Christian

2017-11-23

Humans' core body temperature (CBT) is strictly controlled within a narrow range. Various studies dealt with the impact of physical activity, clothing, and environmental factors on CBT regulation under terrestrial conditions. However, the effects of weightlessness on human thermoregulation are not well understood. Specifically, studies, investigating the effects of long-duration spaceflight on CBT at rest and during exercise are clearly lacking. We here show that during exercise CBT rises higher and faster in space than on Earth. Moreover, we observed for the first time a sustained increased astronauts' CBT also under resting conditions. This increase of about 1 °C developed gradually over 2.5 months and was associated with augmented concentrations of interleukin-1 receptor antagonist, a key anti-inflammatory protein. Since even minor increases in CBT can impair physical and cognitive performance, both findings have a considerable impact on astronauts' health and well-being during future long-term spaceflights. Moreover, our findings also pinpoint crucial physiological challenges for spacefaring civilizations, and raise questions about the assumption of a thermoregulatory set point in humans, and our evolutionary ability to adapt to climate changes on Earth.

Some significant considerations in the planning of sortie missions. [of space transportation system

NASA Technical Reports Server (NTRS)

Loftus, J. P., Jr.; Cour-Palais, B. G.; Moore, J. W.; Lohman, R. L.

1980-01-01

Opportunities and limitations to be considered in the planning of Space Shuttle/Spacelab sortie missions are discussed. As shown by a simple model of the flow of STS equipment through ground processing and flights under ideal conditions, mission duration is constrained by Orbiter availability, which is determined initially by the Orbiter production schedule and the turnaround time required between missions, and by the usage rate and quantity limitations of mission consumables. Additional considerations affecting mission duration include reductions in crew productivity upon increased mission duration and crew size, spacecraft and experiment degradation, equipment and processing facility cost effectiveness, and requirements for a power extension package, which considerations imply that increased allowable landing weight would make co-manifesting (the combination of Spacelab and deliverable payload missions) more attractive. Advantages related to payload recoverability, human presence, ease of access and the availability of different orbits are also pointed out.

Decisional Information System for Safety (D.I.S.S.) Dedicated to the Human Space Exploration Mission

NASA Astrophysics Data System (ADS)

Grès, Stéphane; Guyonnet, Jean-François

2006-06-01

At the heart of the issue of reliable and dependable systems and networks, this paper presents the conception of a Decisional Information System for Security (D.I.S.S.) dedicated to the Human Space Exploration Mission. The objective is to conceive a decisional information system for human long duration space flight (> 1000 days) which is realised in entire autonomy in the solar system. This article describes the importance of the epistemological and ontological context for designing an open, self-learning and reliable system able for self-adapt in dangerous and unforeseen situations. We present in link with our research, the limits of the empirical analytical paradigm and several paths of research lead by the nascent paradigm of enaction. The strong presumption is that the centralised models of security could not be sufficient today to respond and challenge the security of a technical system, which will support human exploration missions.

Trades Between Opposition and Conjunction Class Trajectories for Early Human Missions to Mars

NASA Technical Reports Server (NTRS)

Mattfeld, Bryan; Stromgren, Chel; Shyface, Hilary; Komar, David R.; Cirillo, William; Goodliff, Kandyce

2014-01-01

Candidate human missions to Mars, including NASA's Design Reference Architecture 5.0, have focused on conjunction-class missions with long crewed durations and minimum energy trajectories to reduce total propellant requirements and total launch mass. However, in order to progressively reduce risk and gain experience in interplanetary mission operations, it may be desirable that initial human missions to Mars, whether to the surface or to Mars orbit, have shorter total crewed durations and minimal stay times at the destination. Opposition-class missions require larger total energy requirements relative to conjunction-class missions but offer the potential for much shorter mission durations, potentially reducing risk and overall systems performance requirements. This paper will present a detailed comparison of conjunction-class and opposition-class human missions to Mars vicinity with a focus on how such missions could be integrated into the initial phases of a Mars exploration campaign. The paper will present the results of a trade study that integrates trajectory/propellant analysis, element design, logistics and sparing analysis, and risk assessment to produce a comprehensive comparison of opposition and conjunction exploration mission constructs. Included in the trade study is an assessment of the risk to the crew and the trade offs between the mission duration and element, logistics, and spares mass. The analysis of the mission trade space was conducted using four simulation and analysis tools developed by NASA. Trajectory analyses for Mars destination missions were conducted using VISITOR (Versatile ImpulSive Interplanetary Trajectory OptimizeR), an in-house tool developed by NASA Langley Research Center. Architecture elements were evaluated using EXploration Architecture Model for IN-space and Earth-to-orbit (EXAMINE), a parametric modeling tool that generates exploration architectures through an integrated systems model. Logistics analysis was conducted using NASA's Human Exploration Logistics Model (HELM), and sparing allocation predictions were generated via the Exploration Maintainability Analysis Tool (EMAT), which is a probabilistic simulation engine that evaluates trades in spacecraft reliability and sparing requirements based on spacecraft system maintainability and reparability.

Energy Expenditure During Extravehicular Activity: Apollo Skylab Through STS-135

NASA Technical Reports Server (NTRS)

Paul, Heather L.

2011-01-01

The importance of real-time metabolic rate monitoring during extravehicular activities (EVAs) came into question during the Gemini missions, when the energy expenditure required to conduct an EVA over-tasked the crewmember and exceeded the capabilities of vehicle and space suit life support systems. Energy expenditure was closely evaluated through the Apollo lunar surface EVAs, resulting in modifications to space suit design and EVA operations. After the Apollo lunar surface missions were completed, the United States shifted its focus to long duration human space flight, to study the human response to living and working in a microgravity environment. This paper summarizes the energy expenditure during EVA from Apollo Skylab through STS-135.

Waste streams in a crewed space habitat

NASA Technical Reports Server (NTRS)

Wydeven, T.; Golub, M. A.

1991-01-01

A judicious compilation of generation rates and chemical compositions of potential waste feed streams in a typical crewed space habitat was made in connection with the waste-management aspect of NASA's Physical/Chemical Closed-Loop Life Support Program. Waste composition definitions are needed for the design of waste-processing technologies involved in closing major life support functions in future long-duration human space missions. Tables of data for the constituents and chemical formulas of the following waste streams are presented and discussed: human urine, feces, hygiene (laundry and shower) water, cleansing agents, trash, humidity condensate, dried sweat, and trace contaminants. Tables of data on dust generation and pH values of the different waste streams are also presented and discussed.

Closed-Loop Life Support and Habitability: 2000-2004

NASA Technical Reports Server (NTRS)

2004-01-01

This custom bibliography from the NASA Scientific and Technical Information Program lists a sampling of records found in the NASA Aeronautics and Space Database. The scope of this topic includes technologies for the recycling of oxygen, carbon dioxide, and water for long-duration human presence in space. This area of focus is one of the enabling technologies as defined by NASA s Report of the President s Commission on Implementation of United States Space Exploration Policy, published in June 2004.

Antarctic Space Analog Program

NASA Technical Reports Server (NTRS)

Palinkas, Lawrence A; Gunderson, E. K. Eric; Johnson, Jeffrey C.; Holland, Albert W.

1998-01-01

The primary aim of this project was to examine group dynamics and individual performance in extreme, isolated environments and identify human factors requirements for long-duration space missions using data collected in an analog environment. Specifically, we wished to determine: 1) the characteristics of social relations in small groups of individuals living and working together in extreme, isolated environments, and 2) the environmental, social and psychological determinants of performance effectiveness in such groups. These two issues were examined in six interrelated studies using data collected in small, isolated research stations in Antarctica from 1963 to the present. Results from these six studies indicated that behavior and performance on long-duration space flights is likely to be seasonal or cyclical, situational, social, and salutogenic in nature. The project responded to two NASA program emphases for FY 1997 as described in the NRA: 1) the primary emphasis of the Behavior and Performance Program on determining long-term individual and group performance responses to space, identifying critical factors affecting those responses and understanding underlying mechanisms involved in behavior and performance, and developing and using ground-based models and analogs for studying space-related behavior and performance; and 2) the emphasis of the Data Analysis Program on extended data analysis. Results from the study were used to develop recommendations for the design and development of pre-flight crew training and in-flight psychological countermeasures for long-duration manned space missions.

Risk of Adverse Health Outcomes and Decrements in Performance Due to In-flight Medical Conditions

NASA Technical Reports Server (NTRS)

Antonsen,Erik

2017-01-01

The drive to undertake long-duration space exploration missions at greater distances from Earth gives rise to many challenges concerning human performance under extreme conditions. At NASA, the Human Research Program (HRP) has been established to investigate the specific risks to astronaut health and performance presented by space exploration, in addition to developing necessary countermeasures and technology to reduce risk and facilitate safer, more productive missions in space (NASA Human Research Program 2009). The HRP is divided into five subsections, covering behavioral health, space radiation, habitability, and other areas of interest. Within this structure is the ExMC Element, whose research contributes to the overall development of new technologies to overcome the challenges of expanding human exploration and habitation of space. The risk statement provided by the HRP to the ExMC Element states: "Given that medical conditions/events will occur during human spaceflight missions, there is a possibility of adverse health outcomes and decrements in performance in mission and for long term health" (NASA Human Research Program 2016). Within this risk context, the Exploration Medical Capabilities (ExMC) Element is specifically concerned with establishing evidenced-based methods of monitoring and maintaining astronaut health. Essential to completing this task is the advancement in techniques that identify, prevent, and treat any health threats that may occur during space missions. The ultimate goal of the ExMC Element is to develop and demonstrate a pathway for medical system integration into vehicle and mission design to mitigate the risk of medical issues. Integral to this effort is inclusion of an evidence-based medical and data handling system appropriate for long-duration, exploration-class missions. This requires a clear Concept of Operations, quantitative risk metrics or other tools to address changing risk throughout a mission, and system scoping and system engineering. Because of the novel nature of the risks involved in exploration missions, new and complex ethical challenges are likely to be encountered. This document describes the relevant background and evidence that informs the development of an exploration medical system.

Monitoring of Microbial Loads During Long Duration Missions as a Risk Reduction Tool

NASA Astrophysics Data System (ADS)

Roman, M. C.; Mena, K. D.

2012-01-01

Humans have been exploring space for more than 40 years. For all those years, microorganisms have accompanied both un-manned spacecraft/cargo and manned vessels. Microorganisms are everywhere on Earth, could easily adapt to new environments, and/or can rapidly mutate to survive in very harsh conditions. Their presence in spacecraft and cargo have caused a few inconveniences over the years of human spaceflight, ranging from crew health, life support systems challenges, and material degradation. The sterilization of spacecraft that will host humans in long duration mission would be a costly operation that will not provide a long-term solution to the microbial colonization of the vessels. As soon as a human is exposed to the spacecraft, microorganisms start populating the new environment during the mission. As the human presence in space increases in length, the risk from the microbial load to hardware and crew will also increase. Mitigation of this risk involves several different strategies that will include minimizing the microbial load (in numbers and diversity) and monitoring. This paper will provide a list of the risk mitigation strategies that should be implemented during ground processing, and during the mission. It will also discuss the areas that should be reviewed before an effective in-flight microbial monitoring regimen is implemented.

Circadian Entrainment, Sleep-Wake Regulation and Neurobehavioral Performance During Extended Duration Space Flight

NASA Technical Reports Server (NTRS)

Czeisler, Charles A.

1999-01-01

Long-duration manned space flight requires crew members to maintain a high level of cognitive performance and vigilance while operating and monitoring sophisticated instrumentation. However, the reduction in the strength of environmental synchronizers in the space environment leads to misalignment of circadian phase among crew members, coupled with restricted time available to sleep, results in sleep deprivation and consequent deterioration of neurobehavioral function. Crew members are provided, and presently use, long-acting benzodiazepine hypnotics on board the current, relatively brief space shuttle missions to counteract such sleep disruption, a situation that is only likely to worsen during extended duration missions. Given the known carry-over effects of such compounds on daytime performance, together with the reduction in emergency readiness associated with their use at night, NASA has recognized the need to develop effective but safe countermeasures to allow crew members to obtain an adequate amount of sleep. Over the past eight years, we have successfully implemented a new technology for shuttle crew members involving bright light exposure during the pre-launch period to facilitate adaptation of the circadian timing system to the inversions of the sleep-wake schedule often required during dual shift missions. However for long duration space station missions it will be necessary to develop effective and attainable countermeasures that can be used chronically to optimize circadian entrainment. Our current research effort is to study the effects of light-dark cycles with reduced zeitgeber strength, such as are anticipated during long-duration space flight, on the entrainment of the endogenous circadian timing system and to study the effects of a countermeasure that consists of scheduled brief exposures to bright light on the human circadian timing system. The proposed studies are designed to address the following Specific Aims: (1) test the hypothesis that synchronization of the human circadian pacemaker will be disturbed in men and women by the reduction in LD cycle strength. (2) test the hypothesis that this disturbed circadian synchronization will result in the secretion of the sleep-promoting hormone melatonin during the waking day, disturbed sleep, reduced growth hormone secretion, and impaired performance and daytime alertness; (3) as a countermeasure, test the hypothesis that brief daily exposures to bright light (10,000 lux) will reestablish normal entrained circadian phase, resulting in improved sleep consolidation, normalized sleep structure and endogenous growth hormone secretion and enhanced daytime performance. To date, we have carried out twelve experiments to address Hypotheses I and 2 and data analyses are in progress. The results of the current research may have important implications for the treatment of circadian rhythm sleep disorders, such as delayed sleep phase syndrome and shift-work dyssomnia, which are anticipated to have a high incidence and prevalence during extended duration space flight such as planned for the International Space Station and manned missions to Mars.

Human Health and Performance Considerations for Exploration of Near-Earth Asteroids

NASA Technical Reports Server (NTRS)

Kundrot, Craig; Steinberg, Susan; Charles, John

2010-01-01

This presentation will describe the human health and performance issues that are anticipated for the human exploration of near-Earth asteroids (NEA). Humans are considered a system in the design of any such deep-space exploration mission, and exploration of NEA presents unique challenges for the human system. Key factors that define the mission are those that are strongly affected by distance and duration. The most critical of these is deep-space radiation exposure without even the temporary shielding of a nearby large planetary body. The current space radiation permissible exposure limits (PEL) restrict mission duration to 3-10 months depending on age and gender of crewmembers and stage of the solar cycle. Factors that affect mission architecture include medical capability; countermeasures for bone, muscle, and cardiovascular atrophy during continuous weightlessness; restricted food supplies; and limited habitable volume. The design of a habitat that can maintain the physical and psychological health of the crew and support mission operations with limited intervention from Earth will require an integrated research and development effort by NASA s Human Research Program, engineering, and human factors groups. Limited abort and return options for an NEA mission are anticipated to have important effects on crew psychology as well as influence medical supplies and training requirements of the crew. Other important factors are those related to isolation, confinement, communication delays, autonomous operations, task design, small crew size, and even the unchanging view outside the windows for most of the mission. Geological properties of the NEA will influence design of sample handling and containment, and extravehicular activity capabilities including suit ports and tools. A robotic precursor mission that collects basic information on NEA surface properties would reduce uncertainty about these aspects of the mission as well as aid in design of mission architecture and exploration tasks.

Human Research Program Integrated Research Plan. Revision C

NASA Technical Reports Server (NTRS)

Steinberg, Susan

2011-01-01

Crew health and performance are critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes (1) HRP's approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and (2) the method of integration for risk mitigation. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

Human System Drivers for Exploration Missions

NASA Technical Reports Server (NTRS)

Kundrot, Craig E.; Steinberg, Susan; Charles, John B.

2010-01-01

Evaluation of DRM4 in terms of the human system includes the ability to meet NASA standards, the inclusion of the human system in the design trade space, preparation for future missions and consideration of a robotic precursor mission. Ensuring both the safety and the performance capability of the human system depends upon satisfying NASA Space Flight Human System Standards.1 These standards in turn drive the development of program-specific requirements for Near-earth Object (NEO) missions. In evaluating DRM4 in terms of these human system standards, the currently existing risk models, technologies and biological countermeasures were used. A summary of this evaluation is provided below in a structure that supports a mission architecture planning activities. 1. Unacceptable Level of Risk The duration of the DRM4 mission leads to an unacceptable level of risk for two aspects of human system health: A. The permissible exposure limit for space flight radiation exposure (a human system standard) would be exceeded by DRM4. B. The risk of visual alterations and abnormally high intracranial pressure would be too high. 1

Soviet space flight: the human element.

PubMed

Garshnek, V

1988-05-01

Building on past experience and knowledge, the Soviet manned space flight effort has become broad, comprehensive, and forward-looking. Their long-running space station program has provided the capabilities to investigate long-term effects of microgravity on human physiology and behavior and test various countermeasures against microgravity-induced physiological deconditioning. Since the beginning of Soviet manned space flight, the biomedical training and preparation of cosmonauts has evolved from a process that increased human tolerance to space flight factors, to a system of interrelated measures to prepare cosmonauts physically and psychologically to live and work in space. Currently, the Soviet Union is constructing a multimodular space station, the Mir. With the emergence of dedicated laboratory modules, the Soviets have begun the transition from small-scale experimental research to large-scale production activities and specialized scientific work in space. In the future, additional laboratory modules will be added, including one dedicated to biomedical research, called the "Medilab." The longest manned space flight to date (326 days) has been completed by the Soviets. The biomedical effects of previous long-duration flights, and perhaps those of still greater length, may contribute important insight ito the possibility of extended missions beyond Earth, such as a voyage to Mars.

Simulations of the MATROSHKA experiment at the international space station using PHITS.

PubMed

Sihver, L; Sato, T; Puchalska, M; Reitz, G

2010-08-01

Concerns about the biological effects of space radiation are increasing rapidly due to the perspective of long-duration manned missions, both in relation to the International Space Station (ISS) and to manned interplanetary missions to Moon and Mars in the future. As a preparation for these long-duration space missions, it is important to ensure an excellent capability to evaluate the impact of space radiation on human health, in order to secure the safety of the astronauts/cosmonauts and minimize their risks. It is therefore necessary to measure the radiation load on the personnel both inside and outside the space vehicles and certify that organ- and tissue-equivalent doses can be simulated as accurate as possible. In this paper, simulations are presented using the three-dimensional Monte Carlo Particle and Heavy-Ion Transport code System (PHITS) (Iwase et al. in J Nucl Sci Tech 39(11):1142-1151, 2002) of long-term dose measurements performed with the European Space Agency-supported MATROSHKA (MTR) experiment (Reitz and Berger in Radiat Prot Dosim 120:442-445, 2006). MATROSHKA is an anthropomorphic phantom containing over 6,000 radiation detectors, mimicking a human head and torso. The MTR experiment, led by the German Aerospace Center (DLR), was launched in January 2004 and has measured the absorbed doses from space radiation both inside and outside the ISS. Comparisons of simulations with measurements outside the ISS are presented. The results indicate that PHITS is a suitable tool for estimation of doses received from cosmic radiation and for study of the shielding of spacecraft against cosmic radiation.

Skylab

NASA Image and Video Library

1972-01-01

This set of photographs details Skylab's Human Vestibular Function experiment (M131). This experiment was a set of medical studies designed to determine the effect of long-duration space missions on astronauts' coordination abilities. This experiment tested the astronauts susceptibility to motion sickness in the Skylab environment, acquired data fundamental to an understanding of the functions of human gravity reception under prolonged absence of gravity, and tested for changes in the sensitivity of the semicircular canals. Data from this experiment was collected before, during, and after flight. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Habitability research priorities for the International Space Station and beyond.

PubMed

Whitmore, M; Adolf, J A; Woolford, B J

2000-09-01

Advanced technology and the desire to explore space have resulted in increasingly longer manned space missions. Long Duration Space Flights (LDSF) have provided a considerable amount of scientific research on the ability of humans to adapt and function in microgravity environments. In addition, studies conducted in analogous environments, such as winter-over expeditions in Antarctica, have complemented the scientific understanding of human performance in LDSF. These findings indicate long duration missions may take a toll on the individual, both physiologically and psychologically, with potential impacts on performance. Significant factors in any manned LDSF are habitability, workload and performance. They are interrelated and influence one another, and therefore necessitate an integrated research approach. An integral part of this approach will be identifying and developing tools not only for assessment of habitability, workload, and performance, but also for prediction of these factors as well. In addition, these tools will be used to identify and provide countermeasures to minimize decrements and maximize mission success. The purpose of this paper is to identify research goals and methods for the International Space Station (ISS) in order to identify critical factors and level of impact on habitability, workload, and performance, and to develop and validate countermeasures. Overall, this approach will provide the groundwork for creating an optimal environment in which to live and work onboard ISS as well as preparing for longer planetary missions.

Research Priorities for the International Space Station and Beyond

NASA Technical Reports Server (NTRS)

Whitmore, Mihriban; Adolf, Jurine A.; Woolford, Barbara J.

1999-01-01

Advanced technology and the desire to explore space have resulted in increasingly longer manned space missions. Long Duration Space Flights (LDSF) have provided a considerable amount of scientific research on the ability of humans to adapt and function in microgravity environments. In addition, studies conducted in analogous environments, such as winter-over expeditions in Antarctica, have complemented the scientific understanding of human performance in LDSF. These findings indicate long duration missions may take a toll on the individual, both physiologically and psychologically, with potential impacts on performance. Significant factors in any manned LDSF are habitability, workload and performance. They are interrelated and influence one another, and therefore necessitate an integrated research approach. An integral part of this approach will be identifying and developing tools not only for assessment of habitability, workload, and performance, but also for prediction of these factors as well. In addition, these tools will be used to identify and provide countermeasures to minimize decrements and maximize mission success. The purpose of this paper is to identify research goals and methods for the International Space Station (ISS) in order to identify critical factors and level of impact on habitability, workload, and performance, and to develop and validate countermeasures. Overall, this approach will provide the groundwork for creating an optimal environment in which to live and work onboard ISS as well as preparing for longer planetary missions.

NUTRITION w/Repository

NASA Image and Video Library

2009-06-06

ISS020-E-007577 (6 June 2009) --- European Space Agency astronaut Frank De Winne, Expedition 20 flight engineer, returns a dewar tray to the Minus Eighty Laboratory Freezer for ISS (MELFI) after inserting biological samples into the trays in the Kibo laboratory of the International Space Station. Samples were taken as part of the Nutritional Status Assessment (Nutrition) with Repository experiment, a study done by NASA to date of human physiologic changes during long-duration spaceflight.

Space Radiation and Risks to Human Health

NASA Technical Reports Server (NTRS)

Huff, Janice L.

2014-01-01

The radiation environment in space poses significant challenges to human health and is a major concern for long duration manned space missions. Outside the Earth's protective magnetosphere, astronauts are exposed to higher levels of galactic cosmic rays, whose physical characteristics are distinct from terrestrial sources of radiation such as x-rays and gamma-rays. Galactic cosmic rays consist of high energy and high mass nuclei as well as high energy protons; they impart unique biological damage as they traverse through tissue with impacts on human health that are largely unknown. The major health issues of concern are the risks of radiation carcinogenesis, acute and late decrements to the central nervous system, degenerative tissue effects such as cardiovascular disease, as well as possible acute radiation syndromes due to an unshielded exposure to a large solar particle event. The NASA Human Research Program's Space Radiation Program Element is focused on characterization and mitigation of these space radiation health risks along with understanding these risks in context of the other biological stressors found in the space environment. In this overview, we will provide a description of these health risks and the Element's research strategies to understand and mitigate these risks.

A long term model of circulation. [human body

NASA Technical Reports Server (NTRS)

White, R. J.

1974-01-01

A quantitative approach to modeling human physiological function, with a view toward ultimate application to long duration space flight experiments, was undertaken. Data was obtained on the effect of weightlessness on certain aspects of human physiological function during 1-3 month periods. Modifications in the Guyton model are reviewed. Design considerations for bilateral interface models are discussed. Construction of a functioning whole body model was studied, as well as the testing of the model versus available data.

Exploring the living universe: A strategy for space life sciences

NASA Technical Reports Server (NTRS)

1988-01-01

The status and goals of NASA's life sciences programs are examined. Ways and mean for attaining these goals are suggested. The report emphasizes that a stronger life sciences program is imperative if the U.S. space policy is to construct a permanently manned space station and achieve its stated goal of expanding the human presence beyond earth orbit into the solar system. The same considerations apply in regard to the other major goal of life sciences: to study the biological processes and life in the universe. A principal recommendation of the report is for NASA to expand its program of ground- and space-based research contributing to resolving questions about physiological deconditioning, radiation exposure, potential psychological difficulties, and life support requirements that may limit stay times for personnel on the Space Station and complicate missions of more extended duration. Other key recommendations call for strengthening programs of biological systems research in: controlled ecological life support systems for humans in space, earth systems central to understanding the effects on the earth's environment of both natural and human activities, and exobiology.

Design and Verification

NASA Technical Reports Server (NTRS)

Thompson, Shelby G.; Howard, Robert L., Jr.; Litaker, Harry L., Jr.

2008-01-01

As future space missions become longer, an important aspect to consider is the habitability of the spacecraft. The amount of habitable volume affects not only astronaut comfort, but safety and mission success as well. However, as the volume is increased to aid in task performance, the weight of the vehicle and cost of the mission escalates in proportion. Pressure to reduce mission cost is constant, but the risk to mission success and crew survival must remain the priorities. The Constellation Program's Altair Lunar Lander is designed for short duration surface operation missions of seven to ten days. For short duration missions, humans will tolerate fairly primitive environmental situations provided the basic physiological arrangements are acceptable. However, for long-duration lunar surface operations, the living and operational spaces within which the crew work must provide both the essentials of life, as well as the support necessary for the crew to be productive in accomplishing their mission. The Altair is still in the preliminary design phase, which is the optimal time for Human Factors data to be provided to designers and engineers. A Human Centered Design (HCD) approach is being taken with our Human Factors evaluations. Human-in-the-loop testing is conducted using low-medium fidelity mock-ups of proposed lunar architecture. Based on current ConOps (Concept of Operations) procedures, a task analysis is performed in which individual tasks are combined into larger operational scenarios. Subjective and objective performance measures are gathered at both the task and scenario level. These scores are used to determine the functionality of the vehicle in terms of task performance. Results from these evaluations will highlight areas for design or operational improvement.

Conducting Closed Habitation Experiments: Experience from the Lunar Mars Life Support Test Project

NASA Technical Reports Server (NTRS)

Barta, Daniel J.; Edeen, Marybeth A.; Henninger, Donald L.

2004-01-01

The Lunar-Mars Life Support Test Project (LMLSTP) was conducted from 1995 through 1997 at the National Aeronautics and Space Administration s (NASA) Johnson Space Center (JSC) to demonstrate increasingly longer duration operation of integrated, closed-loop life support systems that employed biological and physicochemical techniques for water recycling, waste processing, air revitalization, thermal control, and food production. An analog environment for long-duration human space travel, the conditions of isolation and confinement also enabled studies of human factors, medical sciences (both physiology and psychology) and crew training. Four tests were conducted, Phases I, II, IIa and III, with durations of 15, 30,60 and 91 days, respectively. The first phase focused on biological air regeneration, using wheat to generate enough oxygen for one experimental subject. The systems demonstrated in the later phases were increasingly complex and interdependent, and provided life support for four crew members. The tests were conducted using two human-rated, atmospherically-closed test chambers, the Variable Pressure Growth Chamber (VPGC) and the Integrated Life Support Systems Test Facility (ILSSTF). Systems included test articles (the life support hardware under evaluation), human accommodations (living quarters, kitchen, exercise equipment, etc.) and facility systems (emergency matrix system, power, cooling, etc.). The test team was managed by a lead engineer and a test director, and included test article engineers responsible for specific systems, subsystems or test articles, test conductors, facility engineers, chamber operators and engineering technicians, medical and safety officers, and science experimenters. A crew selection committee, comprised of psychologists, engineers and managers involved in the test, evaluated male and female volunteers who applied to be test subjects. Selection was based on the skills mix anticipated for each particular test, and utilized information from psychological and medical testing, data on the knowledge, experience and skills of the applicants, and team building exercises. The design, development, buildup and operation of test hardware and documentation followed the established NASA processes and requirements for test buildup and operation.

Conducting Closed Habitation Experiments: Experience from the Lunar Mars Life Support Test Project

NASA Technical Reports Server (NTRS)

Barta, Daniel J.; Edeen, Marybeth A.; Henninger, Donald L.

2006-01-01

The Lunar-Mars Life Support Test Project (LMLSTP) was conducted from 1995 through 1997 at the National Aeronautics and Space Administration s (NASA) Johnson Space Center (JSC) to demonstrate increasingly longer duration operation of integrated, closed-loop life support systems that employed biological and physicochemical techniques for water recycling, waste processing, air revitalization, thermal control, and food production. An analog environment for long-duration human space travel, the conditions of isolation and confinement also enabled studies of human factors, medical sciences (both physiology and psychology) and crew training. Four tests were conducted, Phases I, II, IIa and III, with durations of 15, 30, 60 and 91 days, respectively. The first phase focused on biological air regeneration, using wheat to generate enough oxygen for one experimental subject. The systems demonstrated in the later phases were increasingly complex and interdependent, and provided life support for four crew members. The tests were conducted using two human-rated, atmospherically-closed test chambers, the Variable Pressure Growth Chamber (VPGC) and the Integrated Life Support Systems Test Facility (ILSSTF). Systems included test articles (the life support hardware under evaluation), human accommodations (living quarters, kitchen, exercise equipment, etc.) and facility systems (emergency matrix system, power, cooling, etc.). The test team was managed by a lead engineer and a test director, and included test article engineers responsible for specific systems, subsystems or test articles, test conductors, facility engineers, chamber operators and engineering technicians, medical and safety officers, and science experimenters. A crew selection committee, comprised of psychologists, engineers and managers involved in the test, evaluated male and female volunteers who applied to be test subjects. Selection was based on the skills mix anticipated for each particular test, and utilized information from psychological and medical testing, data on the knowledge, experience and skills of the applicants, and team building exercises. The design, development, buildup and operation of test hardware and documentation followed the established NASA processes and requirements for test buildup and operation.

The role of physiotherapy in the European Space Agency strategy for preparation and reconditioning of astronauts before and after long duration space flight.

PubMed

Lambrecht, Gunda; Petersen, Nora; Weerts, Guillaume; Pruett, Casey; Evetts, Simon; Stokes, Maria; Hides, Julie

2017-01-01

Spaceflight and exposure to microgravity have wide-ranging effects on many systems of the human body. At the European Space Agency (ESA), a physiotherapist plays a key role in the multidisciplinary ESA team responsible for astronaut health, with a focus on the neuro-musculoskeletal system. In conjunction with a sports scientist, the physiotherapist prepares the astronaut for spaceflight, monitors their exercise performance whilst on the International Space Station (ISS), and reconditions the astronaut when they return to Earth. This clinical commentary outlines the physiotherapy programme, which was developed over nine long-duration missions. Principles of physiotherapy assessment, clinical reasoning, treatment programme design (tailored to the individual) and progression of the programme are outlined. Implications for rehabilitation of terrestrial populations are discussed. Evaluation of the reconditioning programme has begun and challenges anticipated after longer missions, e.g. to Mars, are considered. Copyright © 2016 Elsevier Ltd. All rights reserved.

Considerations for development of countermeasures for physiological decrements associated with long-duration space missions

NASA Astrophysics Data System (ADS)

Sawin, Charles F.; Hayes, Judith; Francisco, David R.; House, Nancy

2007-02-01

Countermeasures are necessary to offset or minimize the deleterious changes in human physiology resulting from long duration space flight. Exposure to microgravity alters musculoskeletal, neurosensory, and cardiovascular systems with resulting deconditioning that may compromise crew health and performance. Maintaining health and fitness at acceptable levels is critical for preserving performance capabilities required to accomplish specific mission tasks (e.g.—extravehicular activity) and to optimize performance after landing. To enable the goals of the exploration program, NASA is developing a new suite of exercise hardware such as the improved loading device, the SchRED. This presentation will update the status of current countermeasures, correlate hardware advances with improvements in exercise countermeasures, and discuss future activities for safe and productive exploration missions.

Factors Impacting Habitable Volume Requirements: Results from the 2011 Habitable Volume Workshop

NASA Technical Reports Server (NTRS)

Simon, M.; Whitmire, A.; Otto, C.; Neubek, D. (Editor)

2011-01-01

This report documents the results of the Habitable Volume Workshop held April 18-21, 2011 in Houston, TX at the Center for Advanced Space Studies-Universities Space Research Association. The workshop was convened by NASA to examine the factors that feed into understanding minimum habitable volume requirements for long duration space missions. While there have been confinement studies and analogs that have provided the basis for the guidance found in current habitability standards, determining the adequacy of the volume for future long duration exploration missions is a more complicated endeavor. It was determined that an improved understanding of the relationship between behavioral and psychosocial stressors, available habitable and net habitable volume, and interior layouts was needed to judge the adequacy of long duration habitat designs. The workshop brought together a multi-disciplinary group of experts from the medical and behavioral sciences, spaceflight, human habitability disciplines and design professionals. These subject matter experts identified the most salient design-related stressors anticipated for a long duration exploration mission. The selected stressors were based on scientific evidence, as well as personal experiences from spaceflight and analogs. They were organized into eight major categories: allocation of space; workspace; general and individual control of environment; sensory deprivation; social monotony; crew composition; physical and medical issues; and contingency readiness. Mitigation strategies for the identified stressors and their subsequent impact to habitat design were identified. Recommendations for future research to address the stressors and mitigating design impacts are presented.

Calcium Kinetics During Long-Duration Space Flight

NASA Technical Reports Server (NTRS)

Smith, Scott M.; OBrien, K. O.; Wastney, M. E.; Morukov, B. V.; Larina, I.; Abrams, S. A.; Lane, H. W.; Nillen, J. L.; Davis-Street, J. E.; Oganov, V.;

Adaptation and readaptation medical concerns of a Mars trip

NASA Technical Reports Server (NTRS)

Johnson, Philip C.

1986-01-01

The ability of the human body to adapt to microgravity environments and to later readapt to a gravity environment was examined. Issues specifically relating to the effects of long duration space flight on the adaptation/readaptation process are discussed. The need for better health prediction techniques is stressed in order to be able to better anticipate crew health problems and to perform corrective actions. Several specific examples are discussed of latent diseases which could occur during a long duration space mission, even after having subjected the crew to thorough premission checkups. The need for learning how to prevent or ameliorate such problems as space adaptation syndrome, bone and muscle (and possibly tissue) atrophy, immune system atrophy, and heart arrythmias is also discussed. The implications of the age of the crew, the influence of an onboard low level gravity field, and drugs are briefly addressed as factors in the adaptation/readaptation process.

Digital Cellular Solid Pressure Vessels: A Novel Approach for Human Habitation in Space

NASA Technical Reports Server (NTRS)

Cellucci, Daniel; Jenett, Benjamin; Cheung, Kenneth C.

2017-01-01

It is widely assumed that human exploration beyond Earth's orbit will require vehicles capable of providing long duration habitats that simulate an Earth-like environment - consistent artificial gravity, breathable atmosphere, and sufficient living space- while requiring the minimum possible launch mass. This paper examines how the qualities of digital cellular solids - high-performance, repairability, reconfigurability, tunable mechanical response - allow the accomplishment of long-duration habitat objectives at a fraction of the mass required for traditional structural technologies. To illustrate the impact digital cellular solids could make as a replacement to conventional habitat subsystems, we compare recent proposed deep space habitat structural systems with a digital cellular solids pressure vessel design that consists of a carbon fiber reinforced polymer (CFRP) digital cellular solid cylindrical framework that is lined with an ultra-high molecular weight polyethylene (UHMWPE) skin. We use the analytical treatment of a linear specific modulus scaling cellular solid to find the minimum mass pressure vessel for a structure and find that, for equivalent habitable volume and appropriate safety factors, the use of digital cellular solids provides clear methods for producing structures that are not only repairable and reconfigurable, but also higher performance than their conventionally manufactured counterparts.

Radiation risk and human space exploration.

PubMed

Schimmerling, W; Cucinotta, F A; Wilson, J W

2003-01-01

Radiation protection is essential to enable humans to live and work safely in space. Predictions about the nature and magnitude of the risks posed by space radiation are subject to very large uncertainties. Prudent use of worst-case scenarios may impose unacceptable constraints on shielding mass for spacecraft or habitats, tours of duty of crews on Space Station, and on the radius and duration of sorties on planetary surfaces. The NASA Space Radiation Health Program has been devised to develop the knowledge required to accurately predict and to efficiently manage radiation risk. The knowledge will be acquired by means of a peer-reviewed, largely ground-based and investigator-initiated, basic science research program. The NASA Strategic Plan to accomplish these objectives in a manner consistent with the high priority assigned to the protection and health maintenance of crews will be presented. Published by Elsevier Science Ltd on behalf of COSPAR.

Radiation risk and human space exploration

NASA Technical Reports Server (NTRS)

Schimmerling, W.; Cucinotta, F. A.; Wilson, J. W.

2003-01-01

Radiation protection is essential to enable humans to live and work safely in space. Predictions about the nature and magnitude of the risks posed by space radiation are subject to very large uncertainties. Prudent use of worst-case scenarios may impose unacceptable constraints on shielding mass for spacecraft or habitats, tours of duty of crews on Space Station, and on the radius and duration of sorties on planetary surfaces. The NASA Space Radiation Health Program has been devised to develop the knowledge required to accurately predict and to efficiently manage radiation risk. The knowledge will be acquired by means of a peer-reviewed, largely ground-based and investigator-initiated, basic science research program. The NASA Strategic Plan to accomplish these objectives in a manner consistent with the high priority assigned to the protection and health maintenance of crews will be presented. Published by Elsevier Science Ltd on behalf of COSPAR.

The Impact of Mission Duration on a Mars Orbital Mission

NASA Technical Reports Server (NTRS)

Arney, Dale; Earle, Kevin; Cirillo, Bill; Jones, Christopher; Klovstad, Jordan; Grande, Melanie; Stromgren, Chel

2017-01-01

Performance alone is insufficient to assess the total impact of changing mission parameters on a space mission concept, architecture, or campaign; the benefit, cost, and risk must also be understood. This paper examines the impact to benefit, cost, and risk of changing the total mission duration of a human Mars orbital mission. The changes in the sizing of the crew habitat, including consumables and spares, was assessed as a function of duration, including trades of different life support strategies; this was used to assess the impact on transportation system requirements. The impact to benefit is minimal, while the impact on cost is dominated by the increases in transportation costs to achieve shorter total durations. The risk is expected to be reduced by decreasing total mission duration; however, large uncertainty exists around the magnitude of that reduction.

Critical Questions for Space Human Factors

NASA Technical Reports Server (NTRS)

Woolford, Barbara; Bagian, Tandi

2000-01-01

Traditional human factors contributions to NASA's crewed space programs have been rooted in the classic approaches to quantifying human physical and cognitive capabilities and limitations in the environment of interest, and producing recommendations and standards for the selection or design of mission equipment. Crews then evaluate the interfaces, displays, or equipment, and with the assistance of human factors experts, improvements are made as funds, time, control documentation, and weight allow. We have come a long way from the early spaceflight days, where men with the ' right stuff were the solution to operating whatever equipment was given to them. The large and diverse Shuttle astronaut corps has impacted mission designs to accommodate a wide range of human capabilities and preferences. Yet with existing long duration experience, we have seen the need to address a different set of dynamics when designing for optimal crew performance: critical equipment and mission situations degrade, and human function changes with mission environment, situation, and duration. Strategies for quantifying the critical nature of human factors requirements are being worked by NASA. Any exploration-class mission will place new responsibilities on mission designers to provide the crew with the information and resources to accomplish the mission. The current duties of a Mission Control Center to monitor system status, detect degradation or malfunction, and provide a proven solution, will need to be incorporated into on-board systems to allow the crew autonomous decision-making. The current option to resupply and replace mission systems and resources, including both vehicle equipment and human operators, will be removed, so considerations of maintenance, onboard training, and proficiency assessment are critical to providing a self-sufficient crew. As we 'move in' to the International Space Station, there are tremendous opportunities to investigate our ability to design for autonomous crews. Yet prioritizing the research that can and should be done by NASA will be based on the critical nature of the issues, and the impact of the individual research questions on mission design. The risks to crew health and safety associated with answering critical human factors issues must be properly included and communicated in order to support the Agency's decisions regarding future space programs.

International Space Station: Transitional Platform for Moon and Mars

NASA Technical Reports Server (NTRS)

Greeniesen, Michael C.

2006-01-01

Humans on the path to Mars are employing the Space Station to better understand the Life Sciences issues during long duration space flight. In this phase the problems, for example, of bone loss, skeletal muscle atrophy and radiation will be prioritized for countermeasure development. This presentation will feature NASA's critical path to the Moon and Mars as the initial blueprint for addressing these Human Life Sciences challenges necessary to accomplish a successful Mars transit, surface exploration and return to Earth. A Moon base will be the test bed for resolving the engineering obstacles for later establishment of the Mars Crew Habitat. Current engineering concept scenarios for Moon and Mars bases plus Mars transit vehicles will receive the final focus.

Generation rates and chemical compositions of waste streams in a typical crewed space habitat

NASA Technical Reports Server (NTRS)

Wydeven, Theodore; Golub, Morton A.

1990-01-01

A judicious compilation of generation rates and chemical compositions of potential waste feed streams in a typical crewed space habitat was made in connection with the waste-management aspect of NASA's Physical/Chemical Closed-Loop Life Support Program. Waste composition definitions are needed for the design of waste-processing technologies involved in closing major life support functions in future long-duration human space missions. Tables of data for the constituents and chemical formulas of the following waste streams are presented and discussed: human urine, feces, hygiene (laundry and shower) water, cleansing agents, trash, humidity condensate, dried sweat, and trace contaminants. Tables of data on dust generation and pH values of the different waste streams are also presented and discussed.

Sleep in space as a new medical frontier: the challenge of preserving normal sleep in the abnormal environment of space missions.

PubMed

Pandi-Perumal, Seithikurippu R; Gonfalone, Alain A

2016-01-01

Space agencies such as the National Aeronautics and Space Administration of the United States, the Russian Federal Space Agency, the European Space Agency, the China National Space Administration, the Japan Aerospace Exploration Agency, and Indian Space Research Organization, although differing in their local political agendas, have a common interest in promoting all applied sciences that may facilitate man's adaptation to life beyond the earth. One of man's most important adaptations has been the evolutionary development of sleep cycles in response to the 24 hour rotation of the earth. Less well understood has been man's biological response to gravity. Before humans ventured into space, many questioned whether sleep was possible at all in microgravity environments. It is now known that, in fact, space travelers can sleep once they leave the pull of the earth's gravity, but that the sleep they do get is not completely refreshing and that the associated sleep disturbances can be elaborate and variable. According to astronauts' subjective reports, the duration of sleep is shorter than that on earth and there is an increased incidence of disturbed sleep. Objective sleep recordings carried out during various missions including the Skylab missions, space shuttle missions, and Mir missions all support the conclusion that, compared to sleep on earth, the duration in human sleep in space is shorter, averaging about six hours. In the new frontier of space exploration, one of the great practical problems to be solved relates to how man can preserve "normal" sleep in a very abnormal environment. The challenge of managing fatigue and sleep loss during space mission has critical importance for the mental efficiency and safety of the crew and ultimately for the success of the mission itself. Numerous "earthly" examples now show that crew fatigue on ships, trucks, and long-haul jetliners can lead to inadequate performance and sometimes fatal consequences, a reality which has caused many space agencies to take the issue of sleep seriously.

The use of biomechanics in the study of movement in microgravity

NASA Technical Reports Server (NTRS)

Gregor, R. J.; Broker, J. P.; Ryan, M. M.

1994-01-01

As biomechanists interested in the adaptability of the human body to microgravity conditions, it appears that our job is not only to make sure that the astronauts can function adequately in space but also that they can function upon their return to Earth. This is especially significant since many of the projects now being designed at NASA concern themselves with humans performing for up to 3 years in microgravity. While the Extended Duration Orbiter flights may last 30 to 60 days, future flights to Mars using current propulsion technology may last from 2 to 3 years. It is for this range of time that the adaptation process must be studied. Specifically, biomechanists interested in space travel realize that human performance capabilities will change as a result of exposure to microgravity. The role of the biomechanist then is to first understand the nature of the changes realized by the body. These changes include adaptation by the musculoskeletal system, the nervous system, cardiorespiratory system, and the cardiovascular system. As biomechanists, it is also our role to take part in the development of countermeasure programs that involve some form of regular exercise. Exercise countermeasure programs should include a variety of modalities with full knowledge of the loads imposed on the body by these modalities. Any exercise programs that are to be conducted by the astronauts during space travel must consider the fact that the musculoskeletal and neuromuscular systems degrade as a function of flight duration. Additionally, it must be understood that the central nervous system modifies its output in the control of the human body during space flight and most importantly, we must prepare the astronauts for their return to one g.

Towards human exploration of space: the THESEUS review series on muscle and bone research priorities.

PubMed

Lang, Thomas; Van Loon, Jack J W A; Bloomfield, Susan; Vico, Laurence; Chopard, Angele; Rittweger, Joern; Kyparos, Antonios; Blottner, Dieter; Vuori, Ilkka; Gerzer, Rupert; Cavanagh, Peter R

2017-01-01

Without effective countermeasures, the musculoskeletal system is altered by the microgravity environment of long-duration spaceflight, resulting in atrophy of bone and muscle tissue, as well as in deficits in the function of cartilage, tendons, and vertebral disks. While inflight countermeasures implemented on the International Space Station have evidenced reduction of bone and muscle loss on low-Earth orbit missions of several months in length, important knowledge gaps must be addressed in order to develop effective strategies for managing human musculoskeletal health on exploration class missions well beyond Earth orbit. Analog environments, such as bed rest and/or isolation environments, may be employed in conjunction with large sample sizes to understand sex differences in countermeasure effectiveness, as well as interaction of exercise with pharmacologic, nutritional, immune system, sleep and psychological countermeasures. Studies of musculoskeletal biomechanics, involving both human subject and computer simulation studies, are essential to developing strategies to avoid bone fractures or other injuries to connective tissue during exercise and extravehicular activities. Animal models may be employed to understand effects of the space environment that cannot be modeled using human analog studies. These include studies of radiation effects on bone and muscle, unraveling the effects of genetics on bone and muscle loss, and characterizing the process of fracture healing in the mechanically unloaded and immuno-compromised spaceflight environment. In addition to setting the stage for evidence-based management of musculoskeletal health in long-duration space missions, the body of knowledge acquired in the process of addressing this array of scientific problems will lend insight into the understanding of terrestrial health conditions such as age-related osteoporosis and sarcopenia.

Mineral and nitrogen metabolic studies, experiment M071

NASA Technical Reports Server (NTRS)

Whedon, G. D.; Lutwak, L.; Rambaut, P. C.; Whittle, M. W.; Smith, M. C., Jr.; Reid, J.; Leach, C. S.; Stadler, C. R.; Sanford, D. D.

1977-01-01

The similarity between bed rest test and space flight effects on human mineral and nitrogen metabolisms indicates impairment of capable musculoskeletal functions. A pattern of urinary calcium increases and total calcium shifts suggests that calcium losses continue with time. Significant losses of nitrogen and phosphorus are associated with reduction in muscle tissue. It is concluded that capable musculoskeletal function is likely to be impaired during space flights of 1 1/2 to 3 years duration.

NUTRITION w/Repository

NASA Image and Video Library

2009-06-06

ISS020-E-007603 (7 June 2009) --- European Space Agency astronaut Frank De Winne, Expedition 20 flight engineer, removes a dewar tray from the Minus Eighty Laboratory Freezer for ISS (MELFI) in order to insert biological samples into the trays in the Kibo laboratory of the International Space Station. Samples were taken as part of the Nutritional Status Assessment (Nutrition) with Repository experiment, a study done by NASA to date of human physiologic changes during long-duration spaceflight.

ISS Habitability Data Collection and Preliminary Findings

NASA Technical Reports Server (NTRS)

Thaxton, Sherry (Principal Investigator); Greene, Maya; Schuh, Susan; Williams, Thomas; Archer, Ronald; Vasser, Katie

2017-01-01

Habitability is the relationship between an individual and their surroundings (i.e. the interplay of the person, machines, environment, and mission). The purpose of this study is to assess habitability and human factors on the ISS to better prepare for future long-duration space flights. Scheduled data collection sessions primarily require the use of iSHORT (iPad app) to capture near real-time habitability feedback and analyze vehicle layout and space utilization.

A Lean, Fast Mars Round-trip Mission Architecture: Using Current Technologies for a Human Mission in the 2030s

NASA Technical Reports Server (NTRS)

Bailey, Lora; Folta, David; Barbee, Brent W.; Vaughn, Frank; Kirchman, Frank; Englander, Jacob; Campbell, Bruce; Thronson, Harley; Lin, Tzu Yu

2013-01-01

We present a lean fast-transfer architecture concept for a first human mission to Mars that utilizes current technologies and two pivotal parameters: an end-to-end Mars mission duration of approximately one year, and a deep space habitat of approximately 50 metric tons. These parameters were formulated by a 2012 deep space habitat study conducted at the NASA Johnson Space Center (JSC) that focused on a subset of recognized high- engineering-risk factors that may otherwise limit space travel to destinations such as Mars or near-Earth asteroid (NEA)s. With these constraints, we model and promote Mars mission opportunities in the 2030s enabled by a combination of on-orbit staging, mission element pre-positioning, and unique round-trip trajectories identified by state-of-the-art astrodynamics algorithms.

Hatch opening of the Soyuz TMA-16M

NASA Image and Video Library

2015-03-28

ISS043E059259 (03/28/2015) --- NASA astronaut Scott Kelly (left) is happy to be aboard the International Space Station after the hatch opening of the Soyuz spacecraft Mar. 28, 2015. Kelly traveled with Expedition 43 Russian cosmonauts Mikhail Kornienko and Gennady Padalka of the Russian Federal Space Agency (Roscosmos) on the Soyuz TMA-16M that launched Friday, March 27, 2015 from Baikonur, Kazakhstan. Kelly and Kornienko will spend a year in space and return to Earth on Soyuz TMA-18M in March 2016. Most expeditions to the space station last four to six months. By doubling the length of this mission, researchers hope to better understand how the human body reacts and adapts to long-duration spaceflight. This knowledge is critical as NASA looks toward human journeys deeper into the solar system, including to and from Mars.

Scott Kelly Talks About His Year in Space

NASA Image and Video Library

2016-05-25

An agency wide All-Hands event on May 25 at NASA Headquarters featured Deputy Administrator Dava Newman and retired NASA astronaut Scott Kelly, reflecting on Kelly’s one-year mission aboard the International Space Station. The event, shown on NASA TV and the agency’s website, also featured video highlights of the mission and questions from employees watching at NASA centers around the country. During the unprecedented ISS mission, Kelly and Mikhail Kornienko of Roscosmos collected critical data on how the human body responds to long duration space flight.

Cardiovascular responses to microgravity - Adaptation, maladjustment, and countermeasures

NASA Technical Reports Server (NTRS)

Gaffney, F. Andrew

1989-01-01

Humans have worked in space for up to 237 days without significant inflight limitations, although major cardiovascular disability is seen following space flight of even a few days duration. Most of the cardiovascular research on microgravity deconditioning has been observational in character. Detailed studies of mechanisms and causes of postflight exercise intolerance, low blood pressure and fainting in astronauts and cosmonauts have not been done, despite almost 30 years of manned space flight. A review of possible mechanisms of postflight cardiovascular deconditioning and directions for study is provided.

Human Activity Behavior and Gesture Generation in Virtual Worlds for Long- Duration Space Missions. Chapter 8

NASA Technical Reports Server (NTRS)

Sierhuis, Maarten; Clancey, William J.; Damer, Bruce; Brodsky, Boris; vanHoff, Ron

2007-01-01

A virtual worlds presentation technique with embodied, intelligent agents is being developed as an instructional medium suitable to present in situ training on long term space flight. The system combines a behavioral element based on finite state automata, a behavior based reactive architecture also described as subsumption architecture, and a belief-desire-intention agent structure. These three features are being integrated to describe a Brahms virtual environment model of extravehicular crew activity which could become a basis for procedure training during extended space flight.

Human Skeletal Muscle Health with Spaceflight

NASA Astrophysics Data System (ADS)

Trappe, Scott

2012-07-01

This lecture will overview the most recent aerobic and resistance exercise programs used by crewmembers while aboard the International Space Station (ISS) for six months and examine its effectiveness for protecting skeletal muscle health. Detailed information on the exercise prescription program, whole muscle size, whole muscle performance, and cellular data obtained from muscle biopsy samples will be presented. Historically, detailed information on the exercise program while in space has not been available. These most recent exercise and muscle physiology findings provide a critical foundation to guide the exercise countermeasure program forward for future long-duration space missions.

Achieving a balance - Science and human exploration

NASA Technical Reports Server (NTRS)

Duke, Michael B.

1992-01-01

An evaluation is made of the opportunities for advancing the scientific understanding of Mars through a research program, conducted under the egis of NASA's Space Exploration Initiative, which emphasizes the element of human exploration as well as the requisite robotic component. A Mars exploration program that involves such complementary human/robotic components will entail the construction of a closed ecological life-support system, long-duration spacecraft facilities for crews, and the development of extraterrestrial resources; these R&D imperatives will have great subsequent payoffs, both scientific and economic.

Weightlessness and the human skeleton: A new perspective

NASA Technical Reports Server (NTRS)

Holick, Michael F.

1994-01-01

It is now clear after more than two decades of space exploration that one of the major short- and long-term effects of microgravity on the human body is the loss of bone. The purpose of this presentation will be to review the data regarding the impact of microgravity and bed rest on calcium and bone metabolism. The author takes the position in this Socratic debate that the effect of microgravity on bone metabolism can be either reversed or mitigated. As we begins to contemplate long-duration space flight and habitation of Space Station Freedom and the moon, one of the issues that needs to be addressed is whether humans need to maintain a skeleton that has been adapted for the one-g force on earth. Clearly, in the foreseeable future, a healthy and structurally sound skeleton will be required for astronauts to shuttle back and forth from earth to the moon, space station, and Mars. Based on most available data from bed-rest studies and the short- and long-duration microgravity experiences by astronauts and cosmonauts, bone loss is a fact of life in this environment. With the rapid advances in understanding of bone physiology it is now possible to contemplate measures that can prevent or mitigate microgravity-induced bone loss. Will the new therapeutic approaches for enhancing bone mineralization be useful for preventing significant bone loss during long-term space flight? Are there other approaches such as exercise and electrical stimulation that can be used to mitigate the impact of microgravity on the skeleton? A recent study that evaluated the effect of microgravity on bone modeling in developing chick embryos may perhaps provide a new perspective about the impact of microgravity on bone metabolism.

Future human bone research in space

NASA Technical Reports Server (NTRS)

LeBlanc, A.; Shackelford, L.; Schneider, V.

1998-01-01

Skylab crewmembers demonstrated negative calcium (Ca) balance reaching about -300 mg/day by flight day 84. Limited bone density (BMD) measurements documented that bone was not lost equally from all parts of the skeleton. Subsequent BMD studies during long duration Russian flights documented the regional extent of bone loss. These studies demonstrated mean losses in the spine, femur neck, trochanter, and pelvis of about 1%-1.6% with large differences between individuals as well as between bone sites in a given individual. Limited available data indicate postflight bone recovery occurred in some individuals, but may require several years for complete restoration. Long duration bedrest studies showed a similar pattern of bone loss and calcium balance (-180 mg/day) as spaceflight. During long duration bedrest, resorption markers were elevated, formation markers were unchanged, 1,25 vitamin D (VitD) and calcium absorption were decreased, and serum ionized Ca was increased. Although this information is a good beginning, additional spaceflight research is needed to assess architectural and subregional bone changes, elucidate mechanisms, and develop efficient as well as effective countermeasures. Space research poses a number of unique problems not encountered in ground-based laboratory research. Therefore, researchers contemplating human spaceflight research need to consider a number of unique problems related to spaceflight in their experimental design.

Space Psychology and Psychiatry

NASA Astrophysics Data System (ADS)

Kanas, N.; Manzey, D.

2003-09-01

This book deals with psychological, psychiatric, and psychosocial issues that affect people who live and work in space. Unlike other books that focus on anecdotal reports and ground-based simulation studies, this book emphasizes the findings from psychological research conducted during actual space missions. Both authors have been active in such research. What is presented in this readable text has previously been found only in scientific journal articles. Topics that are discussed include: behavioral adaptation to space; human performance and cognitive effects; crewmember interactions; psychiatric responses; psychological counter-measures related to habitability factors, work-design, selection, training, and in-flight monitoring and support; and the impact of expeditionary missions to Mars and beyond. People finding this book of interest will include: psychology and social science students and professors in universities; medical students and residents in psychiatry and aerospace medicine; human factors workers in space and aviation professions; individuals involved with isolated environments on Earth (e.g., the Antarctic, submarines); aerospace workers in businesses and space agencies such as NASA and ESA; and anyone who is interested in learning the facts about the human side of long-duration space missions. Link: http://www.wkap.nl/prod/b/1-4020-1341-8

Immune changes in humans concomitant with space flights of up to 10 days duration

NASA Technical Reports Server (NTRS)

Taylor, Gerald R.

1993-01-01

The time relation of various classes of in-flight human physiological changes is illustrated. Certain problems, such as neurovestibular, fluid, and electrolyte imbalances tend to occur early in a flight, followed by stabilization at some microgravity equilibrium level. Cardiovascular dysfunctions and erythrocyte mass losses appear to follow a similar pattern, although the significant changes occur later in flight. Bone and calcium changes and radiation effects are thought to progressively worsen with time, whereas the time course of immune change is yet to be fully understood. Significant immunologic changes in cosmonauts and astronauts during and after space flight have been documented as have microbiological changes. Thus, space flight can be expected to effect a blunting of the human cellular immune mechanism concomitant with a relative increase in potentially pathogenic microorganisms. This combination would seem to increase the probability of infectious disease events in flight.

Space medicine research: Needs for the 21st century

NASA Technical Reports Server (NTRS)

Pepper, L. J.

1992-01-01

Space medicine research in the 21st century will continue to focus on the four major areas including: (1) expansion of the current incomplete knowledge base of clinical and subclinical physiological changes due to microgravity; (2) development of countermeasures to extend the capabilities of the human performance envelope in extended duration flights; (3) development of novel methods for delivering all aspects of a comprehensive health care system in extreme remote conditions: and (4) further research and application of systems for biological materials processing. New space transportation vehicles will place unique physiologic and human factors demands on the human system, while providing better access to platforms for materials processing. Success in meeting the demands in each of the noted research areas will require an extensive, interactive team approach. Personnel from the medical research,operational, developmental, and basic science communities will be essential to success.

National Space Biomedical Research Institute Annual Report

NASA Technical Reports Server (NTRS)

2000-01-01

This report summarizes the activities of the National Space Biomedical Research Institute (NSBRI) during FY 2000. The NSBRI is responsible for the development of countermeasures against the deleterious effects of long-duration space flight and performs fundamental and applied space biomedical research directed towards this specific goal. Its mission is to lead a world-class, national effort in integrated, critical path space biomedical research that supports NASA's Human Exploration and Development of Space (HEDS) Strategic Plan by focusing on the enabling of long-term human presence in, development of, and exploration of space. This is accomplished by: designing, testing and validating effective countermeasures to address the biological and environmental impediments to long-term human space flight; defining the molecular, cellular, organ-level, integrated responses and mechanistic relationships that ultimately determine these impediments, where such activity fosters the development of novel countermeasures; establishing biomedical support technologies to maximize human performance in space, reduce biomedical hazards to an acceptable level, and deliver quality medical care; transferring and disseminating the biomedical advances in knowledge and technology acquired through living and working in space to the general benefit of mankind, including the treatment of patients suffering from gravity- and radiation-related conditions on Earth; and ensuring open involvement of the scientific community, industry and the public at large in the Institute's activities and fostering a robust collaboration with NASA, particularly through NASA's Lyndon B. Johnson Space Center. Attachment:Appendices (A,B,C,D,E,F,G,H,I,J,K,L,M,N,O, and P.).

Skylab

NASA Image and Video Library

1970-01-01

This 1970 photograph shows the Rotating Litter Chair, a major component of Skylab's Human Vestibular Function experiment (M131). The experiment was a set of medical studies designed to determine the effect of long-duration space missions on astronauts' coordination abilities. The M131 experiment tested the astronauts susceptibility to motion sickness in the Skylab environment, acquired data fundamental to an understanding of the functions of human gravity reception under prolonged absence of gravity, and tested for changes in the sensitivity of the semicircular canals. Data from this experiment was collected before, during, and after flight. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

Ground-based research with heavy ions for space radiation protection

NASA Astrophysics Data System (ADS)

Durante, M.; Kronenberg, A.

Human exposure to ionizing radiation is one of the acknowledged potential showstoppers for long duration manned interplanetary missions. Human exploratory missions cannot be safely performed without a substantial reduction of the uncertainties associated with different space radiation health risks, and the development of effective countermeasures. Most of our knowledge of the biological effects of heavy charged particles comes from accelerator-based experiments. During the 35th COSPAR meeting, recent ground-based experiments with high-energy iron ions were discussed, and these results are briefly summarised in this paper. High-quality accelerator-based research with heavy ions will continue to be the main source of knowledge of space radiation health effects and will lead to reductions of the uncertainties in predictions of human health risks. Efforts in materials science, nutrition and pharmaceutical sciences and their rigorous evaluation with biological model systems in ground-based accelerator experiments will lead to the development of safe and effective countermeasures to permit human exploration of the Solar System.

Comparison of Propulsion Options for Human Exploration of Mars

NASA Technical Reports Server (NTRS)

Drake, Bret G.; McGuire, Melissa L.; McCarty, Steven L.

2018-01-01

NASA continues to advance plans to extend human presence beyond low-Earth orbit leading to human exploration of Mars. The plans being laid out follow an incremental path, beginning with initial flight tests followed by deployment of a Deep Space Gateway (DSG) in cislunar space. This Gateway, will serve as the initial transportation node for departing and returning Mars spacecraft. Human exploration of Mars represents the next leap for humankind because it will require leaving Earth on a long mission with very limited return, rescue, or resupply capabilities. Although Mars missions are long, approaches and technologies are desired which can reduce the time that the crew is away from Earth. This paper builds off past analyses of NASA's exploration strategy by providing more detail on the performance of alternative in-space transportation options with an emphasis on reducing total mission duration. Key options discussed include advanced chemical, nuclear thermal, nuclear electric, solar electric, as well as an emerging hybrid propulsion system which utilizes a combination of both solar electric and chemical propulsion.

STATUS OF THE SYSTEM OF SIGNALING PATTERN RECOGNITION RECEPTORS OF MONOCYTES AND GRANULOCYTES IN COSMONAUTS' PERIPHERAL BLOOD BEFORE AND AFTER LONG-DURATION MISSIONS TO THE INTERNATIONAL SPACE STATION.

PubMed

Ponomarev, S A; Berendeeva, T A; Kalinin, S A; Muranova, A V

The system of signaling pattern recognition receptors was studied in 8 cosmonauts aged 35 to 56 years before and after (R+) long-duration missions to the International space station. Peripheral blood samples were analyzed for the content of monocytes and granulocytes that express the signaling pattern recognition Toll- like (TLR) receptors localized as on cell surface (TLR1, TLR2, TLR4, TLR5, TLR6), so inside cells (TLR3, TLR8, TLR9). In parallel, serum concentrations of TLR2 (HSP60) and TLR4 ligands (HSP70, HMGB1) were measured. The results of investigations showed growth of HSP60, HSP70 and HMGB1 concentrations on R+1. In the;majority of cosmonauts increases in endogenous ligands were followed by growth in the number of both monocytes and granulocytes that express TLR2 1 TLR4. This consistency gives ground to assume that changes in the system of signaling pattern recognition receptors can stem .from the predominantly endogenous ligands' response to the effects of long-duration space flight on human organism.

Microbial Contamination in the Spacecraft

NASA Technical Reports Server (NTRS)

Pierson, Duane L.

2001-01-01

Spacecraft and space habitats supporting human exploration contain a diverse population of microorganisms. Microorganisms may threaten human habitation in many ways that directly or indirectly impact the health, safety, or performance of astronauts. The ability to produce and maintain spacecraft and space stations with environments suitable for human habitation has been established over 40 years of human spaceflight. An extensive database of environmental microbiological parameters has been provided for short-term (< 20 days) spaceflight by more than 100 missions aboard the Space Shuttle. The NASA Mir Program provided similar data for long-duration missions. Interestingly, the major bacterial and fungal species found in the Space Shuttle are similar to those encountered in the nearly 15-year-old Mir. Lessons learned from both the US and Russian space programs have been incorporated into the habitability plan for the International Space Station. The focus is on preventive measures developed for spacecraft, cargo, and crews. On-orbit regular housekeeping practices complete with visual inspections are essential, along with microbiological monitoring. Risks associated with extended stays on the Moon or a Mars exploration mission will be much greater than previous experiences because of additional unknown variables. The current knowledge base is insufficient for exploration missions, and research is essential to understand the effects of spaceflight on biological functions and population dynamics of microorganisms in spacecraft.

Nutritional Status Assessment

NASA Technical Reports Server (NTRS)

Smith, Scott M.

2008-01-01

Nutritional Status Assessment (Nutrition) is the most comprehensive inflight study done by NASA to date of human physiologic changes during long-duration space flight; this includes measures of bone metabolism, oxidative damage, nutritional assessments, and hormonal changes. This study will impact both the definition of nutritional requirements and development of food systems for future space exploration missions to the Moon and Mars. This experiment will also help to understand the impact of countermeasures (exercise and pharmaceuticals) on nutritional status and nutrient requirements for astronauts.

Wakata and Thirsk with MELFI in KIBO

NASA Image and Video Library

2009-06-15

ISS020-E-010021 (15 June 2009) --- Canadian Space Agency astronaut Robert Thirsk (left) and Japan Aerospace Exploration Agency (JAXA) astronaut Koichi Wakata, both Expedition 20 flight engineers, prepare to put samples in the Minus Eighty Laboratory Freezer for ISS (MELFI) in the Kibo laboratory of the International Space Station. Samples were taken as part of the Nutritional Status Assessment (Nutrition) with Repository experiment, a study done by NASA to date of human physiologic changes during long-duration spaceflight.

Mitigating HZE Radiation-Induced Deficits in Marrow-Derived Mesenchymal Progenitor Cells and Skeletal Structure

NASA Technical Reports Server (NTRS)

Globus, Ruth K.; Schreurs, Ann-Sofie; Shirazi-Fard, Yasaman; Terada, Masahiro; Alwood, Joshua; Halloran, Bernard; Tahimic, Candice

2016-01-01

Future long-duration space exploration beyond the earths magnetosphere will increase human exposure to space radiation and associated risks to skeletal health. We hypothesize that oxidative stress resulting from radiation exposure causes progressive bone loss and dysfunction in associated tissue. In animal studies, increased free radical formation is associated with pathological changes in bone structure, enhanced bone resorption, reduced bone formation and decreased bone mineral density, which can lead to skeletal fragility.

A review of algal research in space

NASA Astrophysics Data System (ADS)

Niederwieser, Tobias; Kociolek, Patrick; Klaus, David

2018-05-01

With the continued expansion of human presence into space, typical mission durations will routinely exceed six months and extend to distances beyond the Moon. As such, sending periodic resupply vehicles, as currently provided to the International Space Station, will likely no longer be feasible. Instead, self-sustaining life support systems that recycle human waste products will become increasingly necessary, especially for planetary bases. The idea of bioregenerative life support systems using algal photobioreactors has been discussed since the beginning of the space age. In order to evaluate how such a system could be implemented, a variety of space flight studies aimed at characterizing the potential for using algae in air revitalization, water recycling, food production, and radiation shielding applications have been conducted over the years. Also, given the recent, growing interest in algal research for regenerative fuel production, food supplements, and cosmetics, many algal strains are already well documented from related terrestrial experiments. This paper reviews past algal experiments flown in space from 1960 until today. Experimental methods and results from 51 investigations utilizing either green algae (Chlorophyta), cyanobacteria (Cyanophyta), or Euglenophyta are analyzed and categorized by a variety of parameters, including size, species and duration. The collected data are summarized in a matrix that allows easy comparison between the experiments and provides important information for future life support system requirement definition and design. Similarities between experiment results are emphasized. Common problems and shortcomings are summarized and analyzed in terms of potential solutions. Finally, key research gaps, which must be closed before developing a functional life support system, are identified.

HRP Chief Scientist's Office: Conducting Research to Enable Deep Space Exploration

NASA Technical Reports Server (NTRS)

Charles, J. B.; Fogarty, J.; Vega, L.; Cromwell, R. L.; Haven, C. P.; McFather, J. C.; Savelev, I.

2017-01-01

The HRP Chief Scientist's Office sets the scientific agenda for the Human Research Program. As NASA plans for deep space exploration, HRP is conducting research to ensure the health of astronauts, and optimize human performance during extended duration missions. To accomplish this research, HRP solicits for proposals within the U.S., collaborates with agencies both domestically and abroad, and makes optimal use of ISS resources in support of human research. This session will expand on these topics and provide an opportunity for questions and discussion with the HRP Chief Scientist. Presentations in this session will include: NRA solicitations - process improvements and focus for future solicitations, Multilateral Human Research Panel for Exploration - future directions (MHRPE 2.0), Extramural liaisons - National Science Foundation (NSF) and Department of Defense (DOD), Standardized Measures for spaceflight, Ground-based Analogs - international collaborations, and International data sharing.

Bone loss and human adaptation to lunar gravity

NASA Technical Reports Server (NTRS)

Keller, T. S.; Strauss, A. M.

1992-01-01

Long-duration space missions and establishment of permanently manned bases on the Moon and Mars are currently being planned. The weightless environment of space and the low-gravity environments of the Moon and Mars pose an unknown challenge to human habitability and survivability. Of particular concern in the medical research community today is the effect of less than Earth gravity on the human skeleton, since the limits, if any, of human endurance in low-gravity environments are unknown. This paper provides theoretical predictions on bone loss and skeletal adaptation to lunar and other nonterrestrial-gravity environments based upon the experimentally derived relationship, density approximately (mass x gravity)(exp 1/8). The predictions are compared to skeletal changes reported during bed rest, immobilization, certrifugation, and spaceflight. Countermeasures to reduce bone losses in fractional gravity are also discussed.

The Value of Biomedical Simulation Environments to Future Human Space Flight Missions

NASA Technical Reports Server (NTRS)

Mulugeta,Lealem; Myers, Jerry G.; Lewandowski, Beth; Platts, Steven H.

2011-01-01

Mars and NEO missions will expose astronaut to extended durations of reduced reduced gravity, isolation and higher radiation. These new operation conditions pose health risks that are not well understood and perhaps unanticipated. Advanced computational simulation environments can beneficially augment research to predict, assess and mitigate potential hazards to astronaut health. The NASA Digital Astronaut Project (DAP), within the NASA Human Research Program, strives to achieve this goal.

Fuel cells, electrolyzers, and microalgae photobioreactors: technologies for long-duration missions in human spaceflight

NASA Astrophysics Data System (ADS)

Belz, Stefan; Bretschneider, Jens; Nathanson, Emil; Buchert, Melanie

Long-duration and far-distant missions in human spaceflight have higher requirements on life support systems (LSS) technologies than for missions into low Earth orbit (LEO). LSS technologies have to ensure that humans can survive, live, and work in space. Enhancements of existing technologies, new technological developments and synergetic components integration help to close the oxygen, water and carbon loops. For these reasons, the approach of a synergetic integration of Polymer Electrolyte Membrane Fuel Cells (PEFC), Polymer Electrolyte Membrane Electrolyzers (PEL) and Photobioreactors (PBR) for microalgae cultivation into the LSS is investigated. It is demonstrated in which mission scenarii the application of PEFC, PEL, and PBR are useful in terms of mass, reliability, and cycle closures. The paper represents the current status of research at the Institute of Space Systems (IRS) of University of Stuttgart on PEFC, PEL, and PBR development. A final configuration of a prototype of a PEFC system includes the gas, water, and thermal management. The PEL is a state-of-the-art technology for space application, but the specific requirements by a synergetic integration are focused. A prototype configuration of a PBR system, which was tested under microgravity conditions in a parabolic experiment, consists of a highly sophisticated cultivation chamber, adapted sensorics, pumps, nutrients supply and harvesting unit. Additionally, the latest results of the cultivation of the microalgae species Chlorella vulgaris and Scenedesmus obliquus in the laboratories of the IRS are represented. Both species are robust, nutrient-rich for human diet. An outlook of the next steps is given for in-orbit verification.

Long-term personality data collection in support of spaceflight and analogue research.

PubMed

Musson, David M; Helmreich, Robert L

2005-06-01

This is a review of past and present research into personality and performance at the University of Texas (UT) Human Factors Research Project. Specifically, personality trait data collected from astronauts, pilots, Antarctic personnel, and other groups over a 15-yr period is discussed with particular emphasis on research in space and space analogue environments. The UT Human Factors Research Project conducts studies in personality and group dynamics in aviation, space, and medicine. Current studies include personality determinants of professional cultures, team effectiveness in both medicine and aviation, and personality predictors of long-term astronaut performance. The Project also studies the design and effectiveness of behavioral strategies used to minimize error and maximize team performance in safety-critical work settings. A multi-year personality and performance dataset presents many opportunities for research, including long-term and follow-up studies of human performance, analyses of trends in recruiting and attrition, and the ability to adapt research design to operational changes and methodological advances. Special problems posed by such long-duration projects include issues of confidentiality and security, as well as practical limitations imposed by current peer-review and short-term funding practices. Practical considerations for ongoing dataset management include consistency of assessment instruments over time, variations in data acquisition from one year to the next, and dealing with changes in theory and practice that occur over the life of the project. A fundamental change in how research into human performance is funded would be required to ensure the ongoing development of such long-duration research databases.

International Space Station Urine Monitoring System Functional Integration and Science Testing

NASA Technical Reports Server (NTRS)

Rodriguez, Branelle R.; Broyan, James Lee, Jr.

2008-01-01

Exposure to microgravity during human spaceflight is required to be defined and understood as the human exploration of space requires longer duration missions. It is known that long term exposure to microgravity causes bone loss. Urine voids are capable of measuring the calcium and other metabolic byproducts in a constituent s urine. The International Space Station (ISS) Urine Monitoring System (UMS) is an automated urine collection device designed to collect urine, separate the urine and air, measure the void volume, and allow for syringe sampling. Accurate measuring and minimal cross contamination is essential to determine bone loss and the effectiveness of countermeasures. The ISS UMS provides minimal cross contamination (<0.7 ml urine) and has volume accuracy of +/-2% between 100 to 1000 ml urine voids.

International Space Station Urine Monitoring System Functional Integration and Science Testing

NASA Technical Reports Server (NTRS)

Cibuzar, Branelle R.; Broyan, James Lee, Jr.

2009-01-01

Exposure to microgravity during human spaceflight is required to be defined and understood as the human exploration of space requires longer duration missions. It is known that long term exposure to microgravity causes bone loss. Urine voids are capable of measuring the calcium and other metabolic byproducts in a constituent s urine. The International Space Station (ISS) Urine Monitoring System (UMS) is an automated urine collection device designed to collect urine, separate the urine and air, measure the void volume, and allow for syringe sampling. Accurate measuring and minimal cross contamination is essential to determine bone loss and the effectiveness of countermeasures. The ISS UMS provides minimal cross contamination (<0.7 ml urine) and has volume accuracy of +/-2% between 100 to 1000 ml urine voids.

Developing a Crew Time Model for Human Exploration Missions to Mars

NASA Technical Reports Server (NTRS)

Battfeld, Bryan; Stromgren, Chel; Shyface, Hilary; Cirillo, William; Goodliff, Kandyce

2015-01-01

Candidate human missions to Mars require mission lengths that could extend beyond those that have previously been demonstrated during crewed Lunar (Apollo) and International Space Station (ISS) missions. The nature of the architectures required for deep space human exploration will likely necessitate major changes in how crews operate and maintain the spacecraft. The uncertainties associated with these shifts in mission constructs - including changes to habitation systems, transit durations, and system operations - raise concerns as to the ability of the crew to complete required overhead activities while still having time to conduct a set of robust exploration activities. This paper will present an initial assessment of crew operational requirements for human missions to the Mars surface. The presented results integrate assessments of crew habitation, system maintenance, and utilization to present a comprehensive analysis of potential crew time usage. Destination operations were assessed for a short (approx. 50 day) and long duration (approx. 500 day) surface habitation case. Crew time allocations are broken out by mission segment, and the availability of utilization opportunities was evaluated throughout the entire mission progression. To support this assessment, the integrated crew operations model (ICOM) was developed. ICOM was used to parse overhead, maintenance and system repair, and destination operations requirements within each mission segment - outbound transit, Mars surface duration, and return transit - to develop a comprehensive estimation of exploration crew time allocations. Overhead operational requirements included daily crew operations, health maintenance activities, and down time. Maintenance and repair operational allocations are derived using the Exploration Maintainability and Analysis Tool (EMAT) to develop a probabilistic estimation of crew repair time necessary to maintain systems functionality throughout the mission.

Next Space Station Crew Previews Mission

NASA Image and Video Library

2017-10-11

NASA astronaut Scott Tingle and crewmates Anton Shkaplerov of the Russian space agency Roscosmos and Norishege Kanai of the Japan Aerospace Exploration Agency (JAXA) discussed their upcoming mission to the International Space Station in a news conference on Oct. 11 at NASA’s Johnson Space Center in Houston. Tingle, Shkaplerov and Kanai will launch to the space station aboard the Soyuz MS-07 spacecraft on Dec. 17 from the Baikonur Cosmodrome in Kazakhstan. They will join the station’s Expedition 54 crew, and return to Earth in April 2018 as members of Expedition 55. During a planned four-month mission, the station crew members will take part in about 250 research investigations and technology demonstrations not possible on Earth in order to advance scientific knowledge of Earth, space, physical and biological sciences. Science conducted on the space station continues to yield benefits for humanity and will enable future long-duration human and robotic exploration into deep space, including missions past the Moon and Mars. This will be the first spaceflight for Tingle and Kanai, and the third for Shkaplerov.

Automation of closed environments in space for human comfort and safety

NASA Technical Reports Server (NTRS)

1991-01-01

The results of the second year of a three year design project on the automation of the Environmental Control and Life Support System (ECLSS) of the Space Station Freedom (SSF) are presented. The results are applicable to other space missions that require long duration space habitats. A description of conceptual controls which are developed for the Water Recovery and Management (WRM) Subassembly is given. Mathematical modeling of the Air Revitalization (AR) Subassembly is presented. The work done by the Kansas State University NASA/USRA interdisciplinary student design team is concluded with a discussion of the expert system which was developed for the AR Subassembly.

Latent virus reactivation in astronauts on the international space station.

PubMed

Mehta, Satish K; Laudenslager, Mark L; Stowe, Raymond P; Crucian, Brian E; Feiveson, Alan H; Sams, Clarence F; Pierson, Duane L

2017-01-01

Reactivation of latent herpes viruses was measured in 23 astronauts (18 male and 5 female) before, during, and after long-duration (up to 180 days) spaceflight onboard the international space station . Twenty age-matched and sex-matched healthy ground-based subjects were included as a control group. Blood, urine, and saliva samples were collected before, during, and after spaceflight. Saliva was analyzed for Epstein-Barr virus, varicella-zoster virus, and herpes simplex virus type 1. Urine was analyzed for cytomegalovirus. One astronaut did not shed any targeted virus in samples collected during the three mission phases. Shedding of Epstein-Barr virus, varicella-zoster virus, and cytomegalovirus was detected in 8 of the 23 astronauts. These viruses reactivated independently of each other. Reactivation of Epstein-Barr virus, varicella-zoster virus, and cytomegalovirus increased in frequency, duration, and amplitude (viral copy numbers) when compared to short duration (10 to 16 days) space shuttle missions. No evidence of reactivation of herpes simplex virus type 1, herpes simplex virus type 2, or human herpes virus 6 was found. The mean diurnal trajectory of salivary cortisol changed significantly during flight as compared to before flight ( P  = 0.010). There was no statistically significant difference in levels of plasma cortisol or dehydoepiandosterone concentrations among time points before, during, and after flight for these international space station crew members, although observed cortisol levels were lower at the mid and late-flight time points. The data confirm that astronauts undertaking long-duration spaceflight experience both increased latent viral reactivation and changes in diurnal trajectory of salivary cortisol concentrations.

Staffing the ISS Control Centers: Lessons Learned from Long-Duration Human Space Flight

NASA Technical Reports Server (NTRS)

Olsen, Carrie D.; Horvath, Timothy J.; Davis, Sally P.

2006-01-01

The International Space Station (ISS) has been in operation with a permanent human presence in space for over five years, and plans for continued operations stretch ten years into the future. Ground control and support operations are, likewise, a 15-year enterprise. This long-term, 24-hour per day, 7 day per week support has presented numerous challenges in the areas of ground crew training, initial and continued certification, and console staffing. The Mission Control Center in Houston, Texas and the Payload Operations Center in Huntsville, Alabama have both tackled these challenges, with similar, yet distinct, approaches. This paper describes the evolution of the staffing and training policies of both control centers in a chronological progression. The relative merits and shortcomings of the various policies employed are discussed and a summary of "lessons learned" is presented. Finally, recommendations are made as best practices for future long-term space missions.

Space Resource Utilization: Near-Term Missions and Long-Term Plans for Human Exploration

NASA Technical Reports Server (NTRS)

Sanders, Gerald B.

2015-01-01

NASA's Human Exploration Plans: A primary goal of all major space faring nations is to explore space: from the Earth with telescopes, with robotic probes and space telescopes, and with humans. For the US National Aeronautics and Space Administration (NASA), this pursuit is captured in three important strategic goals: 1. Ascertain the content, origin, and evolution of the solar system and the potential for life elsewhere, 2. Extend and sustain human activities across the solar system (especially the surface of Mars), and 3. Create innovative new space technologies for exploration, science, and economic future. While specific missions and destinations are still being discussed as to what comes first, it is imperative for NASA that it foster the development and implementation of new technologies and approaches that make space exploration affordable and sustainable. Critical to achieving affordable and sustainable human exploration beyond low Earth orbit (LEO) is the development of technologies and systems to identify, extract, and use resources in space instead of bringing everything from Earth. To reduce the development and implementation costs for space resource utilization, often called In Situ Resource Utilization (ISRU), it is imperative to work with terrestrial mining companies to spin-in/spin-off technologies and capabilities, and space mining companies to expand our economy beyond Earth orbit. In the last two years, NASA has focused on developing and implementing a sustainable human space exploration program with the ultimate goal of exploring the surface of Mars with humans. The plan involves developing technology and capability building blocks critical for sustained exploration starting with the Space Launch System (SLS) and Orion crew spacecraft and utilizing the International Space Station as a springboard into the solar system. The evolvable plan develops and expands human exploration in phases starting with missions that are reliant on Earth, to performing ever more challenging and longer duration missions in cis-lunar space and beyond, to eventually being independent from Earth. The goal is no longer just to reach a destination, but to enable people to work, learn, operate, and live safely beyond the Earth for extended periods of time, ultimately in ways that are more sustainable and even indefinite.

Bronchoesophageal and related systems in space flight

NASA Technical Reports Server (NTRS)

Thornton, William

1991-01-01

A review is presented of the detrimental effects of space flight on the human bronchoesophageal system emphasizing related areas such as the gastric system. In-flight symptoms are listed including congestion, nasopharyngeal irritation, epigastric sensations, anorexia, and nausea. Particular attention is given to space-related effects on eating/drinking associated with the absence of hydrostatic pressure in the vascular system. The atmospheric characteristics of a typical space shuttle flight are given, and the reduced pressure and low humidity are related to bronchial, eye, and nose irritation. Earth and space versions of motion sickness are compared, and some critical differences are identified. It is proposed that more research is required to assess the effects of long-duration space travel on these related systems.

Geo-Statistical Approach to Estimating Asteroid Exploration Parameters

NASA Technical Reports Server (NTRS)

Lincoln, William; Smith, Jeffrey H.; Weisbin, Charles

2011-01-01

NASA's vision for space exploration calls for a human visit to a near earth asteroid (NEA). Potential human operations at an asteroid include exploring a number of sites and analyzing and collecting multiple surface samples at each site. In this paper two approaches to formulation and scheduling of human exploration activities are compared given uncertain information regarding the asteroid prior to visit. In the first approach a probability model was applied to determine best estimates of mission duration and exploration activities consistent with exploration goals and existing prior data about the expected aggregate terrain information. These estimates were compared to a second approach or baseline plan where activities were constrained to fit within an assumed mission duration. The results compare the number of sites visited, number of samples analyzed per site, and the probability of achieving mission goals related to surface characterization for both cases.

Recent Pharmacology Studies on the International Space Station

NASA Technical Reports Server (NTRS)

Wotring, Virginia

2014-01-01

The environment on the International Space Station (ISS) includes a variety of potential stressors including the absence of Earth's gravity, elevated exposure to radiation, confined living and working quarters, a heavy workload, and high public visibility. The effects of this extreme environment on pharmacokinetics, pharmacodynamics, and even on stored medication doses, are not yet understood. Dr. Wotring will discuss recent analyses of medication doses that experienced long duration storage on the ISS and a recent retrospective examination of medication use during long-duration spaceflights. She will also describe new pharmacology experiments that are scheduled for upcoming ISS missions. Dr. Virginia E. Wotring is a Senior Scientist in the Division of Space Life Sciences in the Universities Space Research Association, and Pharmacology Discipline Lead at NASA's Johnson Space Center, Human Heath and Countermeasures Division. She received her doctorate in Pharmacological and Physiological Science from Saint Louis University after earning a B.S. in Chemistry at Florida State University. She has published multiple studies on ligand gated ion channels in the brain and spinal cord. Her research experience includes drug mechanisms of action, drug receptor structure/function relationships and gene & protein expression. She joined USRA (and spaceflight research) in 2009. In 2012, her book reviewing pharmacology in spaceflight was published by Springer: Space Pharmacology, Space Development Series.

Preliminary Assessment of Artificial Gravity Impacts to Deep-Space Vehicle Design

NASA Technical Reports Server (NTRS)

Joosten, B. Kent

2007-01-01

Even after more than thirty years of scientific investigation, serious concerns regarding human physiological effects of long-duration microgravity exposure remain. These include loss of bone mineral density, skeletal muscle atrophy, and orthostatic hypertension, among others. In particular, "Safe Passage: Astronaut Care for Exploration Missions," states "loss of bone density, which apparently occurs at a rate of 1% per month in microgravity, is relatively manageable on the short-duration missions of the space shuttle, but it becomes problematic on the ISS [International Space Station]. ...If this loss is not mitigated, interplanetary missions will be impossible." While extensive investigations into potential countermeasures are planned on the ISS, the delay in attaining full crew complement and onboard facilities, and the potential for extending crews tours of duty threaten the timely (< 20 years!) accumulation of sufficient data for countermeasures formulation. Indeed, there is no guarantee that even with the data, a practical or sufficiently robust set of countermeasures will be forthcoming. Providing an artificial gravity (AG) environment by crew centrifugation aboard deep-space human exploration vehicles, long a staple technique of science fiction, has received surprisingly limited engineering assessment. This is most likely due to a number of factors: the lack of definitive design requirements, especially acceptable artificial gravity levels and rotation rates, the perception of high vehicle mass and performance penalties, the incompatibility of resulting vehicle configurations with space propulsion options (i.e., aerocapture), the perception of complications associated with de-spun components such as antennae and photovoltaic arrays, and the expectation of effective crew micro-gravity countermeasures. These perception and concerns may have been overstated, or may be acceptable alternatives to countermeasures of limited efficacy. This study was undertaken as an initial step to try to understand the implications of and potential solutions to incorporating artificial gravity in the design of human deep-space exploration vehicles. Of prime interest will be the mass penalties incurred by incorporating AG, along with any mission performance degradation.

Sleep and Circadian Rhythms in Four Orbiting Astronauts

NASA Technical Reports Server (NTRS)

Monk, Timothy H.; Buysse, Daniel J.; Billy, Bart D.; Kennedy, Kathy S.; Willrich, Linda M.

1999-01-01

INTRODUCTION The study of human sleep and circadian rhythms in space has both operational and scientific significance. Operationally, U.S. Spaceflight is moving away from brief missions with durations of less than one week. Most space shuttle missions now last two weeks or more, and future plans involving space stations, lunar bases and interplanetary missions all presume that people will be living away from the gravity and time cues of earth for months at a time. Thus, missions are moving away from situations where astronauts can "tough it out" for comparatively brief durations, to situations where sleep and circadian disruptions are likely to become chronic, and thus resistant to short term pharmacological or behavioral manipulations. As well as the operational significance, there is a strong theoretical imperative for studying the sleep and circadian rhythms of people who are removed from the gravity and time cues of earth. Like other animals, in humans, the Circadian Timekeeping System (CTS) is entrained to the correct period (24h) and temporal orientation by various time cues ("zeitgebers"), the most powerful of which is the alternation of daylight and darkness. In leaving Earth, astronauts are removing themselves from the prime zeitgeber of their circadian system -- the 24h alternation of daylight and darkness.

Advanced extravehicular protective systems

NASA Technical Reports Server (NTRS)

Sutton, J. G.; Heimlich, P. F.; Tepper, E. H.

1972-01-01

New technologies are identified and recommended for developing a regenerative portable life support system that provides protection for extravehicular human activities during long duration missions on orbiting space stations, potential lunar bases, and possible Mars landings. Parametric subsystems analyses consider: thermal control, carbon dioxide control, oxygen supply, power supply, contaminant control, humidity control, prime movers, and automatic temperature control.

Pilot Studies on Object Motion Perception During Linear Self-Motion After Long Duration Centrifugation of Human Subjects

DTIC Science & Technology

1993-02-01

Taylor & Creelman , 1967.) Measurements were taken with the sled moving either in forward or backward direction, each threshold being measured once...Furrer, R. & Messerschmid, E. (1990). Space Sickness on Earth. Experimental Brain Research 79(3), 661-663. Taylor, M.M. & Creelman . C.D. (1967). PEST

Wakata and Thirsk with MELFI in KIBO

NASA Image and Video Library

2009-06-15

ISS020-E-010028 (15 June 2009) --- Japan Aerospace Exploration Agency (JAXA) astronaut Koichi Wakata, Expedition 20 flight engineer, returns a dewar tray to the Minus Eighty Laboratory Freezer for ISS (MELFI) after inserting biological samples into the trays in the Kibo laboratory of the International Space Station. Samples were taken as part of the Nutritional Status Assessment (Nutrition) with Repository experiment, a study done by NASA to date of human physiologic changes during long-duration spaceflight. Canadian Space Agency astronaut Robert Thirsk, flight engineer, assisted Wakata.

Sit Up Straight

NASA Technical Reports Server (NTRS)

1998-01-01

BioMetric Systems has an exclusive license to the Posture Video Analysis Tool (PVAT) developed at Johnson Space Center. PVAT uses videos from Space Shuttle flights to identify limiting posture and other human factors in the workplace that could be limiting. The software also provides data that recommends appropriate postures for certain tasks and safe duration for potentially harmful positions. BioMetric Systems has further developed PVAT for use by hospitals, physical rehabilitation facilities, insurance companies, sports medicine clinics, oil companies, manufacturers, and the military.

SKYLAB (SL)-2 - LAUNCH - KSC

NASA Image and Video Library

1973-05-31

S73-27095 (25 May 1973) --- The Skylab 2 crew, consisting of astronauts Charles Conrad Jr., Joseph P. Kerwin and Paul J. Weitz, inside the command module atop a Saturn IB launch vehicle, heads toward the Skylab space station in Earth orbit. The command module was inserted into Earth orbit approximately 10 minutes after liftoff. The three represent the first of three crews who will spend record-setting durations for human beings in space, while performing a variety of experiments. Photo credit: NASA

SKYLAB (SL)-2 - LAUNCH - KSC

NASA Image and Video Library

1973-05-31

S73-27096 (25 May 1973) --- The Skylab 2 crew, consisting of astronauts Charles Conrad Jr., Joseph P. Kerwin and Paul J. Weitz, inside the command module atop a Saturn IB launch vehicle, heads toward the Skylab space station in Earth orbit. The command module was inserted into Earth orbit approximately 10 minutes after liftoff. The three represent the first of three crews who will spend record-setting durations for human beings in space, while performing a variety of experiments. Photo credit: NASA

Nutritional Biochemistry of Space Flight

NASA Technical Reports Server (NTRS)

Smith, Scott M.

2000-01-01

Adequate nutrition is critical for maintenance of crew health during and after extended-duration space flight. The impact of weightlessness on human physiology is profound, with effects on many systems related to nutrition, including bone, muscle, hematology, fluid and electrolyte regulation. Additionally, we have much to learn regarding the impact of weightlessness on absorption, mtabolism , and excretion of nutrients, and this will ultimately determine the nutrient requirements for extended-duration space flight. Existing nutritional requirements for extended-duration space flight have been formulated based on limited flight research, and extrapolation from ground-based research. NASA's Nutritional Biochemistry Laboratory is charged with defining the nutritional requirements for space flight. This is accomplished through both operational and research projects. A nutritional status assessment program is included operationally for all International Space Station astronauts. This medical requirement includes biochemical and dietary assessments, and is completed before, during, and after the missions. This program will provide information about crew health and nutritional status, and will also provide assessments of countermeasure efficacy. Ongoing research projects include studies of calcium and bone metabolism, and iron absorption and metabolism. The calcium studies include measurements of endocrine regulation of calcium homeostasis, biochemical marker of bone metabolism, and tracer kinetic studies of calcium movement in the body. These calcium kinetic studies allow for estimation of intestinal absorption, urinary excretion, and perhaps most importantly - deposition and resorption of calcium from bone. The Calcium Kinetics experiment is currently being prepared for flight on the Space Shuttle in 2001, and potentially for subsequent Shuttle and International Space Station missions. The iron study is intended to assess whether iron absorption is down-regulated dUl1ng space flight. This is critical due to the red blood cell changes which occur, and the increase in iron storage that has been observed after space flight. The Iron Absorption and Metabolism experiment is currently planned for long-term flights on the International Space Station.

Synthetic biology in space: considering the broad societal and ethical implications

NASA Astrophysics Data System (ADS)

Race, Margaret S.; Moses, Jacob; McKay, Christopher; Venkateswaran, Kasthuri J.

2012-02-01

Although the field of synthetic biology is still in its infancy, there are expectations for great advances in the coming decades, both on Earth and potentially in space. Promising applications for long duration space missions include a variety of biologically engineered products and biologically aided processes and technologies, which will undoubtedly be scrutinized for risks and benefits in the broad context of ethical, legal and social realms. By comparing and contrasting features of Earth-based and space-applied synthetic biology, it is possible to identify the likely similarities and differences, and to identify possible challenges ahead for space applications that will require additional research, both in the short and long terms. Using an analytical framework associated with synthetic biology and new technologies on Earth, this paper analyses the kinds of issues and concerns ahead, and identifies those areas where space applications may require additional examination. In general, while Earth- and space-based synthetic biology share many commonalities, space applications have additional challenges such as those raised by space microbiology and environmental factors, legal complications, planetary protection, lack of decision-making infrastructure(s), long duration human missions, terraforming and the possible discovery of extraterrestrial (ET) life. For synthetic biology, the way forward offers many exciting opportunities, but is not without legitimate concerns - for life, environments and society, both on Earth and beyond.

Human-rating Automated and Robotic Systems - (How HAL Can Work Safely with Astronauts)

NASA Technical Reports Server (NTRS)

Baroff, Lynn; Dischinger, Charlie; Fitts, David

2009-01-01

Long duration human space missions, as planned in the Vision for Space Exploration, will not be possible without applying unprecedented levels of automation to support the human endeavors. The automated and robotic systems must carry the load of routine housekeeping for the new generation of explorers, as well as assist their exploration science and engineering work with new precision. Fortunately, the state of automated and robotic systems is sophisticated and sturdy enough to do this work - but the systems themselves have never been human-rated as all other NASA physical systems used in human space flight have. Our intent in this paper is to provide perspective on requirements and architecture for the interfaces and interactions between human beings and the astonishing array of automated systems; and the approach we believe necessary to create human-rated systems and implement them in the space program. We will explain our proposed standard structure for automation and robotic systems, and the process by which we will develop and implement that standard as an addition to NASA s Human Rating requirements. Our work here is based on real experience with both human system and robotic system designs; for surface operations as well as for in-flight monitoring and control; and on the necessities we have discovered for human-systems integration in NASA's Constellation program. We hope this will be an invitation to dialog and to consideration of a new issue facing new generations of explorers and their outfitters.

National Aeronautics and Space Administration (NASA) Environmental Control and Life Support (ECLS) Capability Roadmap Development for Exploration

NASA Technical Reports Server (NTRS)

Bagdigian, Robert M.; Carrasquillo, Robyn L.; Metcalf, Jordan; Peterson, Laurie

2012-01-01

NASA is considering a number of future human space exploration mission concepts. Although detailed requirements and vehicle architectures remain mostly undefined, near-term technology investment decisions need to be guided by the anticipated capabilities needed to enable or enhance the mission concepts. This paper describes a roadmap that NASA has formulated to guide the development of Environmental Control and Life Support Systems (ECLSS) capabilities required to enhance the long-term operation of the International Space Station (ISS) and enable beyond-Low Earth Orbit (LEO) human exploration missions. Three generic mission types were defined to serve as a basis for developing a prioritized list of needed capabilities and technologies. Those are 1) a short duration micro gravity mission; 2) a long duration transit microgravity mission; and 3) a long duration surface exploration mission. To organize the effort, ECLSS was categorized into three major functional groups (atmosphere, water, and solid waste management) with each broken down into sub-functions. The ability of existing, flight-proven state-of-the-art (SOA) technologies to meet the functional needs of each of the three mission types was then assessed. When SOA capabilities fell short of meeting the needs, those "gaps" were prioritized in terms of whether or not the corresponding capabilities enable or enhance each of the mission types. The resulting list of enabling and enhancing capability gaps can be used to guide future ECLSS development. A strategy to fulfill those needs over time was then developed in the form of a roadmap. Through execution of this roadmap, the hardware and technologies needed to enable and enhance exploration may be developed in a manner that synergistically benefits the ISS operational capability, supports Multi-Purpose Crew Vehicle (MPCV) development, and sustains long-term technology investments for longer duration missions. This paper summarizes NASA s ECLSS capability roadmap development process, findings, and recommendation

National Space Biomedical Research Institute

NASA Technical Reports Server (NTRS)

2005-01-01

NSBRI partners with NASA to develop countermeasures against the deleterious effects of long duration space flight. NSBRI's science and technology projects are directed toward this goal, which is accomplished by: 1. Designing, testing and validating effective countermeasures to address the biological and environmental impediments to long-term human space flight. 2. Defining the molecular, cellular, organ-level, integrated responses and mechanistic relationships that ultimately determine these impediments, where such activity fosters the development of novel countermeasures. 3. Establishing biomedical support technologies to maximize human performance in space, reduce biomedical hazards to an acceptable level and deliver quality medical care. 4. Transferring and disseminating the biomedical advances in knowledge and technology acquired through living and working in space to the general benefit of humankind; including the treatment of patients suffering from gravity- and radiation-related conditions on Earth. and 5. ensuring open involvement of the scientific community,industry and the public in the Institute's activities and fostering a robust collaboration with NASA, particularly through JSC.

Long-duration space flight and bed rest effects on testosterone and other steroids.

PubMed

Smith, Scott M; Heer, Martina; Wang, Zuwei; Huntoon, Carolyn L; Zwart, Sara R

2012-01-01

Limited data suggest that testosterone is decreased during space flight, which could contribute to bone and muscle loss. The main objective was to assess testosterone and hormone status in long- and short-duration space flight and bed rest environments and to determine relationships with other physiological systems, including bone and muscle. Blood and urine samples were collected before, during, and after long-duration space flight. Samples were also collected before and after 12- to 14-d missions and from participants in 30- to 90-d bed rest studies. Space flight studies were conducted on the International Space Station and before and after Space Shuttle missions. Bed rest studies were conducted in a clinical research center setting. Data from Skylab missions are also presented. All of the participants were male, and they included 15 long-duration and nine short-duration mission crew members and 30 bed rest subjects. Serum total, free, and bioavailable testosterone were measured along with serum and urinary cortisol, serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and SHBG. Total, free, and bioavailable testosterone was not changed during long-duration space flight but were decreased (P < 0.01) on landing day after these flights and after short-duration space flight. There were no changes in other hormones measured. Testosterone concentrations dropped before and soon after bed rest, but bed rest itself had no effect on testosterone. There was no evidence for decrements in testosterone during long-duration space flight or bed rest.

Calcium Kinetics During Space Flight

NASA Technical Reports Server (NTRS)

Smith, Scott M.; Wastney, Meryl E.; OBrien, Kimberly O.; Lane, Helen W.

1999-01-01

Bone loss is one of the most detrimental effects of space flight, threatening to limit the duration of human space missions. The ability to understand and counteract this loss will be critical for crew health and safety during and after extended-duration missions. The hypotheses to be tested in this project are that space flight alters calcium homeostasis and bone mineral metabolism, and that calcium homeostasis and bone mineral metabolism will return to baseline within days to weeks of return to Earth. These hypotheses will be evidenced by elevated rates of bone mineral resorption and decreased bone mineral deposition, decreased absorption of dietary calcium, altered calcitropic endocrine profiles, elevated excretion of calcium in urine and feces, and elevated excretion of markers of bone resorption. The second hypothesis will be evidenced by return of indices of calcium homeostasis and bone metabolism to preflight levels within days to weeks of return to Earth. Studies will be conducted on International Space Station astronauts before, during, and after extended-duration flights. Measurements of calcium kinetics, bone mass, and endocrine/biochemical markers of bone and calcium homeostasis will be conducted. Kinetic studies utilizing dual isotope tracer kinetic studies and mathematical modeling techniques will allow for determination of bone calcium deposition, bone calcium resorption, dietary calcium absorption and calcium excretion (both urinary and endogenous fecal excretion). These studies will build upon preliminary work conducted on the Russian Mir space station. The results from this project will be critical for clarifying how microgravity affects bone and calcium homeostasis, and will provide an important control point for assessment of countermeasure efficacy. These results are expected to aid in developing countermeasures for bone loss, both for space crews and for individuals on Earth who have metabolic bone diseases.

Monitoring of Microbial Loads During Long Duration Missions as a Risk Reduction Tool

NASA Technical Reports Server (NTRS)

Roman, Monsi C.

2011-01-01

Humans have been exploring space for more than 40 years. For all those years microorganisms have accompanied, first un-manned spacecraft/cargo and later manned vessels. Microorganisms are everywhere on Earth, could easily adapt to new environments and/or can rapidly mutate to survive in very harsh conditions. Their presence in spacecraft and cargo have caused a few inconveniences over the years of humans spaceflight, ranging from crew health, life support systems challenges and material degradation. The sterilization of spacecraft that will host humans in long duration mission would be a costly operation that will not provide a long-term solution to the microbial colonization of the vessels. As soon as a human is exposed to the spacecraft, during the mission, microorganisms will start to populate the new environment. As the hum an presence in space increases in length, the risk from the microbial load, to hardware and crew will also increase. Mitigation of this risk includes several different strategies that will include minimizing the microbial load (in numbers and diversity) and monitoring. This presentation will provide a list of the risk mitigation strategies that should be implemented during ground processing, and during the mission. It will also discuss the areas that should be discussed before an effective in-flight microbial monitoring regimen is implemented. Microbial monitoring technologies will also be presented.

NASA FACTS: E. coli AntiMicrobial Satellite (EcAMSat)

NASA Technical Reports Server (NTRS)

Spremo, Stevan; Cappuccio, Gelsomina; Tomko, David

2013-01-01

The E. coli AntiMicrobial Satellite(EcAMSat) mission will investigate space microgravity affects on the antibiotic resistance of E. coli, a bacterial pathogen responsible for urinary tract infection in humans and animals. EcAMSat is being developed through a partnership between NASAs Ames Research Center and the Stanford University School of Medicine. Dr. A.C. Matin is the Stanford University Principal Investigator. EcAMSat will investigate spaceflight effects on bacterial antibiotic resistance and its genetic basis. Bacterial antibiotic resistance may pose a danger to astronauts in microgravity, where the immune response is weakened. Scientists believe that the results of this experiment could help design effective countermeasures to protect astronauts health during long duration human space missions.

Plant diversity to support humans in a CELSS ground based demonstrator

NASA Technical Reports Server (NTRS)

Howe, J. M.; Hoff, J. E.

1981-01-01

A controlled ecological life support system (CELSS) for human habitation in preparation for future long duration space flights is considered. The success of such a system depends upon the feasibility of revitalization of food resources and the human nutritional needs which are to be met by these food resources. Edible higher plants are prime candidates for the photoautotrophic components of this system if nutritionally adequate diets can be derived from these plant sources to support humans. Human nutritional requirements information based on current knowledge are developed for inhabitants envisioned in the CELSS ground based demonstrator. Groups of plant products that can provide the nutrients are identified.

Sleep in space as a new medical frontier: the challenge of preserving normal sleep in the abnormal environment of space missions

PubMed Central

Pandi-Perumal, Seithikurippu R.; Gonfalone, Alain A.

2016-01-01

Space agencies such as the National Aeronautics and Space Administration of the United States, the Russian Federal Space Agency, the European Space Agency, the China National Space Administration, the Japan Aerospace Exploration Agency, and Indian Space Research Organization, although differing in their local political agendas, have a common interest in promoting all applied sciences that may facilitate man’s adaptation to life beyond the earth. One of man’s most important adaptations has been the evolutionary development of sleep cycles in response to the 24 hour rotation of the earth. Less well understood has been man’s biological response to gravity. Before humans ventured into space, many questioned whether sleep was possible at all in microgravity environments. It is now known that, in fact, space travelers can sleep once they leave the pull of the earth’s gravity, but that the sleep they do get is not completely refreshing and that the associated sleep disturbances can be elaborate and variable. According to astronauts’ subjective reports, the duration of sleep is shorter than that on earth and there is an increased incidence of disturbed sleep. Objective sleep recordings carried out during various missions including the Skylab missions, space shuttle missions, and Mir missions all support the conclusion that, compared to sleep on earth, the duration in human sleep in space is shorter, averaging about six hours. In the new frontier of space exploration, one of the great practical problems to be solved relates to how man can preserve “normal” sleep in a very abnormal environment. The challenge of managing fatigue and sleep loss during space mission has critical importance for the mental efficiency and safety of the crew and ultimately for the success of the mission itself. Numerous "earthly" examples now show that crew fatigue on ships, trucks, and long-haul jetliners can lead to inadequate performance and sometimes fatal consequences, a reality which has caused many space agencies to take the issue of sleep seriously. PMID:27217904

Evaluation of proposed Skylab and SSP soap products

NASA Technical Reports Server (NTRS)

Whitmore, F. C.; Durfee, R. L.; Spurlock, J. M.

1973-01-01

Three personal hygiene cleansing agents and one laundry detergent (sodium dodecyl benzene sulfonate), which are all candidates for use on long-duration space missions, were evaluated in terms of dermatological effects on human subjects and effects on microbiological species. None of the four materials exhibited adverse dermatological effects from either skin patch tests of two weeks duration or a simulated Skylab personal hygiene regimen of up to four weeks duration. No significant alterations in skin microflora during the use regimen were found. None of the four materials were found to serve as microbiological support media for the species tested, but a species of air-borne mold was observed to grow rapidly in a neutralized aqueous solution. None of the candidate agents was found to be strongly biocidal.

Lunar and Mars missions - Challenges for advanced life support

NASA Technical Reports Server (NTRS)

Duke, Michael B.

1988-01-01

The development of a suite of scenarios is a prerequisite to the studies that will enable an informed decision by the United States on a program to meet the recently announced space policy goal to expand human presence beyond earth orbit. NASA's Office of Exploration is currently studying a range of initiative options that would extend the sphere of human activity in space to Mars and include permanent bases or outposts on the moon and on Mars. This paper describes the evolutionary lunar base and the Mars expedition scenarios in some detail so that an evaluation can be made from the point of view of human support and opportunities. Alternative approaches in the development of lunar outposts are outlined along with Mars expeditionary scenarios. Human environmental issues are discussed, including: closed loop life support systems; EVA systems; mobility systems; and medical support, physiological deconditioning, and psychological effects associated with long-duration missions.

Logistics Needs for Potential Deep Space Mission Scenarios Post Asteroid Crewed Mission

NASA Technical Reports Server (NTRS)

Lopez, Pedro, Jr.

2015-01-01

A deep-space mission has been proposed to identify and redirect an asteroid to a distant retrograde orbit around the moon, and explore it by sending a crew using the Space Launch System and the Orion spacecraft. The Asteroid Redirect Crewed Mission (ARCM), which represents the third segment of the Asteroid Redirect Mission (ARM), could be performed on EM-3 or EM-4 depending on asteroid return date. Recent NASA studies have raised questions on how we could progress from current Human Space Flight (HSF) efforts to longer term human exploration of Mars. This paper will describe the benefits of execution of the ARM as the initial stepping stone towards Mars exploration, and how the capabilities required to send humans to Mars could be built upon those developed for the asteroid mission. A series of potential interim missions aimed at developing such capabilities will be described, and the feasibility of such mission manifest will be discussed. Options for the asteroid crewed mission will also be addressed, including crew size and mission duration.

Future perspectives on space psychology: Recommendations on psychosocial and neurobehavioural aspects of human spaceflight

NASA Astrophysics Data System (ADS)

De La Torre, Gabriel G.; van Baarsen, Berna; Ferlazzo, Fabio; Kanas, Nick; Weiss, Karine; Schneider, Stefan; Whiteley, Iya

2012-12-01

Recently the psychological effects of space flight have gained in attention. In uncovering the psychological challenges that individuals and teams can face, we need research options that integrate psychosocial aspects with behavioral, performance, technical and environmental issues. Future perspectives in Space Psychology and Human Spaceflight are reviewed in this paper. The topics covered include psychosocial and neurobehavioural aspects, neurocognitive testing tools, decision making, autonomy and delayed communications, well being, mental health, situational awareness, and methodology. Authors were members of a European Space Agency (ESA) Research Topical Team on Psychosocial and Behavioral Aspects of Human Spaceflight. They discuss the different topics under a common perspective of a theoretical and practical framework, showing interactions, relationships and possible solutions for the different aspects and variables in play. Recommendations for every topic are offered and summarized for future research in the field. The different proposed research ideas can be accomplished using analogs and simulation experiments, short- and long-duration bed rest, and in-flight microgravity studies. These topics are especially important for future Moon and Mars mission design and training.

Space Resource Utilization: Near-Term Missions and Long-Term Plans for Human Exploration

NASA Technical Reports Server (NTRS)

Sanders, Gerald B.

2015-01-01

A primary goal of all major space faring nations is to explore space: from the Earth with telescopes, with robotic probes and space telescopes, and with humans. For the US National Aeronautics and Space Administration (NASA), this pursuit is captured in three important strategic goals: 1. Ascertain the content, origin, and evolution of the solar system and the potential for life elsewhere, 2. Extend and sustain human activities across the solar system (especially the surface of Mars), and 3. Create innovative new space technologies for exploration, science, and economic future. While specific missions and destinations are still being discussed as to what comes first, it is imperative for NASA that it foster the development and implementation of new technologies and approaches that make space exploration affordable and sustainable. Critical to achieving affordable and sustainable human exploration beyond low Earth orbit (LEO) is the development of technologies and systems to identify, extract, and use resources in space instead of bringing everything from Earth. To reduce the development and implementation costs for space resource utilization, often called In Situ Resource Utilization (ISRU), it is imperative to work with terrestrial mining companies to spin-in/spin-off technologies and capabilities, and space mining companies to expand our economy beyond Earth orbit. In the last two years, NASA has focused on developing and implementing a sustainable human space exploration program with the ultimate goal of exploring the surface of Mars with humans. The plan involves developing technology and capability building blocks critical for sustained exploration starting with the Space Launch System (SLS) and Orion crew spacecraft and utilizing the International Space Station as a springboard into the solar system. The evolvable plan develops and expands human exploration in phases starting with missions that are reliant on Earth, to performing ever more challenging and longer duration missions in cis-lunar space and beyond, to eventually being independent from Earth. The goal is no longer just to reach a destination, but to enable people to work, learn, operate, and live safely beyond the Earth for extended periods of time, ultimately in ways that are more sustainable and even indefinite.

Human spaceflight and space adaptations: Computational simulation of gravitational unloading on the spine

NASA Astrophysics Data System (ADS)

Townsend, Molly T.; Sarigul-Klijn, Nesrin

2018-04-01

Living in reduced gravitational environments for a prolonged duration such, as a fly by mission to Mars or an extended stay at the international space station, affects the human body - in particular, the spine. As the spine adapts to spaceflight, morphological and physiological changes cause the mechanical integrity of the spinal column to be compromised, potentially endangering internal organs, nervous health, and human body mechanical function. Therefore, a high fidelity computational model and simulation of the whole human spine was created and validated for the purpose of investigating the mechanical integrity of the spine in crew members during exploratory space missions. A spaceflight exposed spine has been developed through the adaptation of a three-dimensional nonlinear finite element model with the updated Lagrangian formulation of a healthy ground-based human spine in vivo. Simulation of the porohyperelastic response of the intervertebral disc to mechanical unloading resulted in a model capable of accurately predicting spinal swelling/lengthening, spinal motion, and internal stress distribution. The curvature of this space adaptation exposed spine model was compared to a control terrestrial-based finite element model, indicating how the shape changed. Finally, the potential of injury sites to crew members are predicted for a typical 9 day mission.

Simulations of MATROSHKA experiments at ISS using PHITS

NASA Astrophysics Data System (ADS)

Puchalska, Monika; Sihver, L.; Sato, T.; Berger, T.; Reitz, G.

Concerns about the biological effects of space radiation are increasing rapidly due to the per-spective of long-duration manned missions, both in relation to the International Space Station (ISS) and to manned interplanetary missions to Moon and Mars in the future. As a prepara-tion for these long duration space missions it is important to ensure an excellent capability to evaluate the impact of space radiation on human health in order to secure the safety of the astronauts/cosmonauts and minimize their risks. It is therefore necessary to measure the radi-ation load on the personnel both inside and outside the space vehicles and certify that organ and tissue equivalent doses can be simulated as accurate as possible. In this paper we will present simulations using the three-dimensional Monte Carlo Particle and Heavy Ion Transport code System (PHITS) of long term dose measurements performed with the ESA supported ex-periment MATROSHKA (MTR), which is an anthropomorphic phantom containing over 6000 radiation detectors, mimicking a human head and torso. The MTR experiment, led by the German Aerospace Center (DLR), was launched in January 2004 and has measured the ab-sorbed dose from space radiation both inside and outside the ISS. In this paper preliminary comparisons of measured and calculated dose and organ doses in the MTR located outside the ISS will be presented. The results confirm previous calculations and measurements which indicate that PHITS is a suitable tool for estimations of dose received from cosmic radiation and when performing shielding design studies of spacecraft. Acknowledgement: The research leading to these results has received funding from the Euro-pean Commission in the frame of the FP7 HAMLET project (Project 218817).

Materials for Shielding Astronauts from the Hazards of Space Radiations

NASA Technical Reports Server (NTRS)

Wilson, J. W.; Cucinotta, F. A.; Miller, J.; Shinn, J. L.; Thibeault, S. A.; Singleterry, R. C.; Simonsen, L. C.; Kim, M. H.

1997-01-01

One major obstacle to human space exploration is the possible limitations imposed by the adverse effects of long-term exposure to the space environment. Even before human spaceflight began, the potentially brief exposure of astronauts to the very intense random solar energetic particle (SEP) events was of great concern. A new challenge appears in deep space exploration from exposure to the low-intensity heavy-ion flux of the galactic cosmic rays (GCR) since the missions are of long duration and the accumulated exposures can be high. Because cancer induction rates increase behind low to rather large thickness of aluminum shielding according to available biological data on mammalian exposures to GCR like ions, the shield requirements for a Mars mission are prohibitively expensive in terms of mission launch costs. Preliminary studies indicate that materials with high hydrogen content and low atomic number constituents are most efficient in protecting the astronauts. This occurs for two reasons: the hydrogen is efficient in breaking up the heavy GCR ions into smaller less damaging fragments and the light constituents produce few secondary radiations (especially few biologically damaging neutrons). An overview of the materials related issues and their impact on human space exploration will be given.

Is a Space Laundry Needed for Exploration?

NASA Technical Reports Server (NTRS)

Ewert, Michael K.; Jeng, Frank F.

2014-01-01

Future human space exploration missions will lengthen to years, and keeping crews clothed without a huge resupply burden is an important consideration for habitation systems. A space laundry system could be the solution; however, the resources it uses must be accounted for and must win out over the very reliable practice of bringing along enough spare underwear. Through NASA's Logistics Reduction and Repurposing project, trade off studies have been conducted to compare current space clothing systems, life extension of that clothing, traditional water based clothes washing and other sanitizing techniques. The best clothing system of course depends on the mission and assumptions, but in general, analysis results indicate that washing clothes on space missions will start to pay off as mission durations push past a year.

Researching Seeds: Films, Sanitation Methods, Microbiological Growth, Viability, and Selection for New Crops

NASA Technical Reports Server (NTRS)

Padgett, Niki; Smith, Trent

2018-01-01

A major factor in long-term human exploration of the solar system is crop growth in microgravity. Space crops can provide fresh, nutritious food to supplement diets for astronauts. Important factors impacting space plant growth and consumption are water delivery to root zone in microgravity, sanitation methods for microbiological safety, plant responses to light quality/spectrum, and identifying optimal edible plants suitable for growth on the International Space Station (ISS). Astronauts growing their own food on the ISS provides necessary data for crop production for long duration deep space missions. The seed film project can be used in Advanced Plant Habitat and Veggies that are currently being utilized on the ISS.

Effects of nuclear cross sections at different energies on the radiation hazard from galactic cosmic rays.

PubMed

Lin, Z W; Adams, J H

2007-03-01

The radiation hazard for astronauts from galactic cosmic rays (GCR) is a major obstacle to long-duration human space exploration. Space radiation transport codes have been developed to calculate the radiation environment on missions to the Moon, Mars, and beyond. We have studied how uncertainties in fragmentation cross sections at different energies affect the accuracy of predictions from such radiation transport calculations. We find that, in deep space, cross sections at energies between 0.3 and 0.85 GeV/nucleon have the largest effect in solar maximum GCR environments. At the International Space Station, cross sections at higher energies have the largest effect due to the geomagnetic cutoff.

NASA's Advanced Life Support Systems Human-Rated Test Facility

NASA Technical Reports Server (NTRS)

Henninger, D. L.; Tri, T. O.; Packham, N. J.

1996-01-01

Future NASA missions to explore the solar system will be long-duration missions, requiring human life support systems which must operate with very high reliability over long periods of time. Such systems must be highly regenerative, requiring minimum resupply, to enable the crews to be largely self-sufficient. These regenerative life support systems will use a combination of higher plants, microorganisms, and physicochemical processes to recycle air and water, produce food, and process wastes. A key step in the development of these systems is establishment of a human-rated test facility specifically tailored to evaluation of closed, regenerative life supports systems--one in which long-duration, large-scale testing involving human test crews can be performed. Construction of such a facility, the Advanced Life Support Program's (ALS) Human-Rated Test Facility (HRTF), has begun at NASA's Johnson Space Center, and definition of systems and development of initial outfitting concepts for the facility are underway. This paper will provide an overview of the HRTF project plan, an explanation of baseline configurations, and descriptive illustrations of facility outfitting concepts.

The Orion Atmosphere Revitalization Technology in Manned Ambient Pressure Space Suit Testing

NASA Technical Reports Server (NTRS)

Button, Amy; Sweterlitsch, Jeffrey

2011-01-01

An amine-based carbon dioxide (CO2) and water vapor sorbent in pressure-swing regenerable beds has been developed by Hamilton Sundstrand and baselined for the Atmosphere Revitalization System (ARS) for moderate duration missions of the Orion Multipurpose Crew Vehicle. The Orion ARS is designed to support not only open-cabin operations, tests of which have been reported in previous years at this conference, but also closed space suit-loop operations. A previous low-pressure suit loop test was performed with a human metabolic simulator, and humans wearing emergency masks were tested in a closed-loop configuration before that. In late 2011, simple tests were performed in a suit-loop configuration with human test subjects in prototype space suits with prototype umbilicals at ambient and two slightly above-ambient pressures. Trace contaminant filters and a prototype blower were also incorporated into the test rig. This paper discusses the performance of the ARS technology in that 2011 test configuration.

Potential Mission Scenarios Post Asteroid Crewed Mission

NASA Technical Reports Server (NTRS)

Lopez, Pedro, Jr.; McDonald, Mark A.

2015-01-01

A deep-space mission has been proposed to identify and redirect an asteroid to a distant retrograde orbit around the moon, and explore it by sending a crew using the Space Launch System and the Orion spacecraft. The Asteroid Redirect Crewed Mission (ARCM), which represents the third segment of the Asteroid Redirect Mission (ARM), could be performed on EM-3 or EM-4 depending on asteroid return date. Recent NASA studies have raised questions on how we could progress from current Human Space Flight (HSF) efforts to longer term human exploration of Mars. This paper will describe the benefits of execution of the ARM as the initial stepping stone towards Mars exploration, and how the capabilities required to send humans to Mars could be built upon those developed for the asteroid mission. A series of potential interim missions aimed at developing such capabilities will be described, and the feasibility of such mission manifest will be discussed. Options for the asteroid crewed mission will also be addressed, including crew size and mission duration.

Applications of telemedicine in the United States space program.

PubMed

Doarn, C R; Nicogossian, A E; Merrell, R C

1998-01-01

Since the beginning of human space flight, NASA has been placing humans in extreme and remote environments. There are many challenges in maintaining humans in outer space, including the provision of life-support systems, radiation shielding, and countermeasures for minimizing the effect of microgravity. Because astronauts are selected for their health, among other factors, disease and illness are minimized. However, it is still of great importance to have appropriate medical care systems in place to address illness and injury should they occur. With the exception of the Apollo program, exploration of space has been limited to missions that are within several hundred miles of the surface of the Earth. At the drawn of the 21st century and the new millennium, human exploration will be focused on operation of the International Space Station (ISS) and preparation for human missions to Mars. These missions will present inherent risks to human health, and, therefore, appropriate plans must be established to address these challenges and risks. Crews of long-duration missions must become more independent from ground controllers. New systems, protocols, and procedures are currently being perfected. Application of emerging technologies in information systems and telecommunications will be critical to inflight medical care. Application of these technologies through telemedicine will provide crew members access to information, noninvasive procedures for assessing health status, and guidance through the integration of sensors, holography, decision-support systems, and virtual environments. These technologies will also serve as a basis to enhance training and medical education. The design of medical care for space flight should lead to a redesign of the practice of medicine on Earth.

Effect of ion concentration changes in the limited extracellular spaces on sarcolemmal ion transport and Ca2+ turnover in a model of human ventricular cardiomyocyte.

PubMed

Hrabcová, Dana; Pásek, Michal; Šimurda, Jiří; Christé, Georges

2013-12-13

We have developed a computer model of human cardiac ventricular myocyte (CVM), including t-tubular and cleft spaces with the aim of evaluating the impact of accumulation-depletion of ions in restricted extracellular spaces on transmembrane ion transport and ionic homeostasis in human CVM. The model was based on available data from human CVMs. Under steady state, the effect of ion concentration changes in extracellular spaces on [Ca2+]i-transient was explored as a function of critical fractions of ion transporters in t-tubular membrane (not documented for human CVM). Depletion of Ca2+ and accumulation of K+ occurring in extracellular spaces slightly affected the transmembrane Ca2+ flux, but not the action potential duration (APD90). The [Ca2+]i-transient was reduced (by 2%-9%), depending on the stimulation frequency, the rate of ion exchange between t-tubules and clefts and fractions of ion-transfer proteins in the t-tubular membrane. Under non-steady state, the responses of the model to changes of stimulation frequency were analyzed. A sudden increase of frequency (1-2.5 Hz) caused a temporal decrease of [Ca2+] in both extracellular spaces, a reduction of [Ca2+]i-transient (by 15%) and APD90 (by 13 ms). The results reveal different effects of activity-related ion concentration changes in human cardiac t-tubules (steady-state effects) and intercellular clefts (transient effects) in the modulation of membrane ion transport and Ca2+ turnover.

Applications of telemedicine in the United States space program

NASA Technical Reports Server (NTRS)

Doarn, C. R.; Nicogossian, A. E.; Merrell, R. C.

1998-01-01

Since the beginning of human space flight, NASA has been placing humans in extreme and remote environments. There are many challenges in maintaining humans in outer space, including the provision of life-support systems, radiation shielding, and countermeasures for minimizing the effect of microgravity. Because astronauts are selected for their health, among other factors, disease and illness are minimized. However, it is still of great importance to have appropriate medical care systems in place to address illness and injury should they occur. With the exception of the Apollo program, exploration of space has been limited to missions that are within several hundred miles of the surface of the Earth. At the drawn of the 21st century and the new millennium, human exploration will be focused on operation of the International Space Station (ISS) and preparation for human missions to Mars. These missions will present inherent risks to human health, and, therefore, appropriate plans must be established to address these challenges and risks. Crews of long-duration missions must become more independent from ground controllers. New systems, protocols, and procedures are currently being perfected. Application of emerging technologies in information systems and telecommunications will be critical to inflight medical care. Application of these technologies through telemedicine will provide crew members access to information, noninvasive procedures for assessing health status, and guidance through the integration of sensors, holography, decision-support systems, and virtual environments. These technologies will also serve as a basis to enhance training and medical education. The design of medical care for space flight should lead to a redesign of the practice of medicine on Earth.

Long-Duration Space Flight and Bed Rest Effects on Testosterone and Other Steroids

PubMed Central

Heer, Martina; Wang, Zuwei; Huntoon, Carolyn L.; Zwart, Sara R.

2012-01-01

Context: Limited data suggest that testosterone is decreased during space flight, which could contribute to bone and muscle loss. Objective: The main objective was to assess testosterone and hormone status in long- and short-duration space flight and bed rest environments and to determine relationships with other physiological systems, including bone and muscle. Design: Blood and urine samples were collected before, during, and after long-duration space flight. Samples were also collected before and after 12- to 14-d missions and from participants in 30- to 90-d bed rest studies. Setting: Space flight studies were conducted on the International Space Station and before and after Space Shuttle missions. Bed rest studies were conducted in a clinical research center setting. Data from Skylab missions are also presented. Participants: All of the participants were male, and they included 15 long-duration and nine short-duration mission crew members and 30 bed rest subjects. Main Outcome Measures: Serum total, free, and bioavailable testosterone were measured along with serum and urinary cortisol, serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and SHBG. Results: Total, free, and bioavailable testosterone was not changed during long-duration space flight but were decreased (P < 0.01) on landing day after these flights and after short-duration space flight. There were no changes in other hormones measured. Testosterone concentrations dropped before and soon after bed rest, but bed rest itself had no effect on testosterone. Conclusions: There was no evidence for decrements in testosterone during long-duration space flight or bed rest. PMID:22049169

Embedding Temporal Constraints For Coordinated Execution in Habitat Automation

NASA Technical Reports Server (NTRS)

Morris, Paul; Schwabacher, Mark; Dalal, Michael; Fry, Charles

2013-01-01

Future NASA plans call for long-duration deep space missions with human crews. Because of light-time delay and other considerations, increased autonomy will be needed. This will necessitate integration of tools in such areas as anomaly detection, diagnosis, planning, and execution. In this paper we investigate an approach that integrates planning and execution by embedding planner-derived temporal constraints in an execution procedure. To avoid the need for propagation, we convert the temporal constraints to dispatchable form. We handle some uncertainty in the durations without it affecting the execution; larger variations may cause activities to be skipped.

Space suit bioenergetics: framework and analysis of unsuited and suited activity.

PubMed

Carr, Christopher E; Newman, Dava J

2007-11-01

Metabolic costs limit the duration and intensity of extravehicular activity (EVA), an essential component of future human missions to the Moon and Mars. Energetics Framework: We present a framework for comparison of energetics data across and between studies. This framework, applied to locomotion, differentiates between muscle efficiency and energy recovery, two concepts often confused in the literature. The human run-walk transition in Earth gravity occurs at the point for which energy recovery is approximately the same for walking and running, suggesting a possible role for recovery in gait transitions. Muscular Energetics: Muscle physiology limits the overall efficiency by which chemical energy is converted through metabolism to useful work. Unsuited Locomotion: Walking and running use different methods of energy storage and release. These differences contribute to the relative changes in the metabolic cost of walking and running as gravity is varied, with the metabolic cost of locomoting at a given velocity changing in proportion to gravity for running and less than in proportion for walking. Space Suits: Major factors affecting the energetic cost of suited movement include suit pressurization, gravity, velocity, surface slope, and space suit configuration. Apollo lunar surface EVA traverse metabolic rates, while unexpectedly low, were higher than other activity categories. The Lunar Roving Vehicle facilitated even lower metabolic rates, thus longer duration EVAs. Muscles and tendons act like springs during running; similarly, longitudinal pressure forces in gas pressure space suits allow spring-like storage and release of energy when suits are self-supporting.

Cryogenic Propellant Storage and Transfer Technology Demonstration: Advancing Technologies for Future Mission Architectures Beyond Low Earth Orbit

NASA Technical Reports Server (NTRS)

Chojnacki, Kent T.; Crane, Deborah J.; Motil, Susan M.; Ginty, Carol A.; Tofil, Todd A.

2014-01-01

As part of U.S. National Space Policy, NASA is seeking an innovative path for human space exploration, which strengthens the capability to extend human and robotic presence throughout the solar system. NASA is laying the groundwork to enable humans to safely reach multiple potential destinations, including the Moon, asteroids, Lagrange points, and Mars and its environs. In support of this, NASA is embarking on the Technology Demonstration Mission Cryogenic Propellant Storage and Transfer (TDM CPST) Project to test and validate key cryogenic capabilities and technologies required for future exploration elements, opening up the architecture for large cryogenic propulsion stages and propellant depots. The TDM CPST will provide an on-orbit demonstration of the capability to store, transfer, and measure cryogenic propellants for a duration that enables long term human space exploration missions beyond low Earth orbit. This paper will present a summary of the cryogenic fluid management technology maturation effort, infusion of those technologies into flight hardware development, and a summary of the CPST preliminary design.

Working hours, sleep, salivary cortisol, fatigue and neuro-behavior during Mars analog mission: five crews study.

PubMed

Rai, Balwant; Foing, Bernard H; Kaur, Jasdeep

2012-05-16

The buoyancy of humans in exploring extreme space environments has been established during missions to the moon. Long duration missions like mission to Mars however, requires humans to adapt to systemic and complex environments beyond the human body's capacity. Astronauts will encounter both physiological and psychological extremes during this trip. Very few studies are conducted on effect of long duration work and sleepiness on cognitive performance. So, this study was planned to find out effects of leadership responsibility, sleepiness and long duration working hours on cognitive performance. The 30 members (leadership: normal; 10:20) were selected from MDRS crews (Mars Desert Research Station, USA). Neurobehavioral test performance, self-ratings of fatigue and sleepiness, and salivary cortisol levels were evaluated during first day, mid and end day of mission. The leadership group did not show any signs of reduced test performance, even in elevated fatigue and sleepiness. The leadership group had faster reaction times on end of mission as compared to first and after 7 day of mission. Salivary cortisol levels were significantly higher in leadership group as compared to normal group. The results suggest that long duration work and sleepiness does not affect the cognitive performance of crew member. Further study is required while taking into account all factors and large sample size to prove this fact. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Astrobiological aspects of Mars and human presence: pros and cons.

PubMed

Horneck, G

2008-08-01

After the realization of the International Space Station, human exploratory missions to Moon or Mars, i.e. beyond low Earth orbit, are widely considered as the next logical step of peaceful cooperation in space on a global scale. Besides the human desire to extend the window of habitability, human exploratory missions are driven by several aspects of science, technology, culture and economy. Mars is currently considered as a major target in the search for life beyond the Earth. Understanding the history of water on Mars appears to be one of the clues to the puzzle on the probability of life on Mars. On Earth microorganisms have flourished for more than 3.5 Ga and have developed strategies to cope with so-called extreme conditions (e.g., hot vents, permafrost, subsurface regions, rocks or salt crystals). Therefore, in search for life on Mars, microorganisms are the most likely candidates for a putative biota on Mars and the search for morphological or chemical signatures of life or its relics is one of the primary and most exciting goals of Mars exploration. The presence of humans on the surface of Mars will substantially increase this research potential, e.g., by supporting deep subsurface drilling and by allowing intellectual collection and sophisticated in situ analysis of samples of astrobiological interest. On the other hand, such long-duration missions beyond LEO will add a new dimension to human space flight, concerning the distance of travel, the radiation environment, the gravity levels, the duration of the mission, and the level of confinement and isolation the crew will be exposed to. This will raise the significance of several health issues, above all radiation protection, gravity related effects as well as psychological issues. Furthermore, the import of internal and external microorganisms inevitably accompanying any human mission to Mars, or brought purposely to Mars as part of a bioregenerative life support system needs careful consideration with regard to planetary protection issues. Therefore, before planning any human exploratory mission, the critical issues concerning human health and wellbeing as well as protection of Mars in its pristine condition need to be investigated.

Astrobiological Aspects of Mars and Human Presence: Pros and Cons

PubMed Central

Horneck, G

2008-01-01

After the realization of the International Space Station, human exploratory missions to Moon or Mars, i.e. beyond low Earth orbit, are widely considered as the next logical step of peaceful cooperation in space on a global scale. Besides the human desire to extend the window of habitability, human exploratory missions are driven by several aspects of science, technology, culture and economy. Mars is currently considered as a major target in the search for life beyond the Earth. Understanding the history of water on Mars appears to be one of the clues to the puzzle on the probability of life on Mars. On Earth microorganisms have flourished for more than 3.5 Ga and have developed strategies to cope with so-called extreme conditions (e.g., hot vents, permafrost, subsurface regions, rocks or salt crystals). Therefore, in search for life on Mars, microorganisms are the most likely candidates for a putative biota on Mars and the search for morphological or chemical signatures of life or its relics is one of the primary and most exciting goals of Mars exploration. The presence of humans on the surface of Mars will substantially increase this research potential, e.g., by supporting deep subsurface drilling and by allowing intellectual collection and sophisticated in situ analysis of samples of astrobiological interest. On the other hand, such long-duration missions beyond LEO will add a new dimension to human space flight, concerning the distance of travel, the radiation environment, the gravity levels, the duration of the mission, and the level of confinement and isolation the crew will be exposed to. This will raise the significance of several health issues, above all radiation protection, gravity related effects as well as psychological issues. Furthermore, the import of internal and external microorganisms inevitably accompanying any human mission to Mars, or brought purposely to Mars as part of a bioregenerative life support system needs careful consideration with regard to planetary protection issues. Therefore, before planning any human exploratory mission, the critical issues concerning human health and wellbeing as well as protection of Mars in its pristine condition need to be investigated. PMID:19048093

Habitation Concepts for Human Missions Beyond Low-Earth-Orbit

NASA Technical Reports Server (NTRS)

Smitherman, David V.

2016-01-01

The Advanced Concepts Office at the NASA Marshall Space Flight Center has been engaged for several years in a variety of study activities to help define various options for deep space habitation. This work includes study activities supporting asteroid, lunar and Mars mission activities for the Human spaceflight Architecture Team (HAT), the Deep Space Habitat (DSH) project, and the Exploration Augmentation Module (EAM) project through the NASA Advanced Exploration Systems (AES) Program. The missions under consideration required human habitation beyond low-Earth-orbit (LEO) including deep space habitation in the lunar vicinity to support asteroid retrieval missions, human and robotic lunar surface missions, deep space research facilities, Mars vehicle servicing, and Mars transit missions. Additional considerations included international interest and near term capabilities through the International Space Station (ISS) and Space Launch System (SLS) programs. A variety of habitat layouts have been considered, including those derived from the existing ISS systems, those that could be fabricated from SLS components, and other approaches. This paper presents an overview of several leading designs explored in late fiscal year (FY) 2015 for asteroid, lunar, and Mars mission habitats and identifies some of the known advantages and disadvantages inherent in each. Key findings indicate that module diameters larger than those used for ISS can offer lighter structures per unit volume, and sufficient volume to accommodate consumables for long-duration missions in deep space. The information provided with the findings includes mass and volume data that should be helpful to future exploration mission planning and deep space habitat design efforts.

Recommended Research on Artificial Gravity. Chapter 13

NASA Technical Reports Server (NTRS)

Vernikos, Joan; Paloski, William; Fuller, Charles; Clement, Gilles

2006-01-01

Based on the summaries presented in the above sections of what is still to be learned on the effects of artificial gravity on human functions, this chapter will discuss the short- and long-term steps of research required to understand fundamentals and to validate operational aspects of using artificial gravity as an effective countermeasure for long-duration space travel.

Enhancing the Meaningfulness of Work for Astronauts on Long Duration Space Exploration Missions.

PubMed

Britt, Thomas W; Sytine, Anton; Brady, Ashley; Wilkes, Russ; Pittman, Rebecca; Jennings, Kristen; Goguen, Kandice

2017-08-01

Numerous authors have identified the stressors likely to be encountered on long duration space exploration missions (e.g., to Mars), including the possibility of significant crises, separation from family, boredom/monotony, and interpersonal conflict. Although many authors have noted that meaningful work may be beneficial for astronauts on these missions, none have detailed the sources of meaningful work for astronauts and how these sources may differ between astronauts. The present article identifies how engagement in meaningful work during long duration missions may mitigate the adverse effects of demands and increase the potential for benefits resulting from the missions. Semistructured interviews were conducted with nine NASA personnel, including astronauts, flight directors, and flight surgeons. Questions addressed sources of meaning for astronauts, characteristics of tasks that enhance vs. detract from meaning, and recommendations for enhancing meaning. Personnel mentioned contributing to humanity and the next generation, contributing to the mission, and exploration as the most meaningful aspects of their work. Characteristics of tasks that enhanced meaning included using a variety of skills, feeling personal control over their schedule, autonomy in the execution of tasks, and understanding the importance of the experiments conducted on the mission. Top recommendations to sustain meaning were insuring social needs were met through such activities as the strategic use of social media, giving astronauts autonomy as well as structure, and conducting training during transit. Implications are addressed for tailoring meaning-based interventions for astronauts participating on long duration missions and assessing the effectiveness of these interventions.Britt TW, Sytine A, Brady A, Wilkes R, Pittman R, Jennings K, Goguen K. Enhancing the meaningfulness of work for astronauts on long duration space exploration missions. Aerosp Med Hum Perform. 2017; 88(8):779-783.

Human Exploration System Test-Bed for Integration and Advancement (HESTIA) Support of Future NASA Deep-Space Missions

NASA Technical Reports Server (NTRS)

Marmolejo, Jose; Ewert, Michael

2016-01-01

The Engineering Directorate at the NASA - Johnson Space Center is outfitting a 20-Foot diameter hypobaric chamber in Building 7 to support future deep-space Environmental Control & Life Support System (ECLSS) research as part of the Human Exploration System Test-bed for Integration and Advancement (HESTIA) Project. This human-rated chamber is the only NASA facility that has the unique experience, chamber geometry, infrastructure, and support systems capable of conducting this research. The chamber was used to support Gemini, Apollo, and SkyLab Missions. More recently, it was used to conduct 30-, 60-, and 90-day human ECLSS closed-loop testing in the 1990s to support the International Space Station and life support technology development. NASA studies show that both planetary surface and deep-space transit crew habitats will be 3-4 story cylindrical structures driven by human occupancy volumetric needs and launch vehicle constraints. The HESTIA facility offers a 3-story, 20-foot diameter habitat consistent with the studies' recommendations. HESTIA operations follow stringent processes by a certified test team that including human testing. Project management, analysis, design, acquisition, fabrication, assembly and certification of facility build-ups are available to support this research. HESTIA offers close proximity to key stakeholders including astronauts, Human Research Program (who direct space human research for the agency), Mission Operations, Safety & Mission Assurance, and Engineering Directorate. The HESTIA chamber can operate at reduced pressure and elevated oxygen environments including those proposed for deep-space exploration. Data acquisition, power, fluids and other facility resources are available to support a wide range of research. Recently completed HESTIA research consisted of unmanned testing of ECLSS technologies. Eventually, the HESTIA research will include humans for extended durations at reduced pressure and elevated oxygen to demonstrate very high reliability of critical ECLSS and other technologies.

Space human factors discipline science plan

NASA Technical Reports Server (NTRS)

1991-01-01

The purpose of this Discipline Science Plan is to provide a conceptual strategy for NASA's Life Sciences Division research and development activities in the comprehensive areas of behavior, performance, and human factors. This document summarizes the current status of the program, outlines available knowledge, establishes goals and objectives, defines critical questions in the subdiscipline areas, and identifies technological priorities. It covers the significant research areas critical to NASA's programmatic requirements for the Extended Duration Orbiter, Space Station Freedom, and Exploration mission science activities. These science activities include ground-based and flight; basic, applied and operational; and animal and human research and development. This document contains a general plan that will be used by both NASA Headquarters program offices and the field centers to review and plan basic, applied, and operational research and development activities, both intramural and extramural, in this area.

[From the flight of Iu. A. Gagarin to the contemporary piloted space flights and exploration missions].

PubMed

Grigor'ev, A I; Potapov, A N

2011-01-01

The first human flight to space made by Yu. A. Gagarin on April 12, 1961 was a crucial event in the history of cosmonautics that had a tremendous effect on further progress of the human civilization. Gagarin's flight had been prefaced by long and purposeful biomedical researches with the use of diverse bio-objects flown aboard rockets and artificial satellites. Data of these researches drove to the conclusion on the possibility in principle for humans to fly to space. After a series of early flights and improvements in the medical support system space missions to the Salyut and Mir station gradually extended to record durations. The foundations of this extension were laid by systemic researches in the fields of space biomedicine and allied sciences. The current ISS system of crew medical care has been successful in maintaining health and performance of cosmonauts as well as in providing the conditions for implementation of flight duties and operations with a broad variety of payloads. The ISS abounds in opportunities of realistic trial of concepts and technologies in preparation for crewed exploration missions. At the same, ground-based simulation of a mission to Mars is a venue for realization of scientific and technological experiments in space biomedicine.

The value and potential of animal research in enabling astronaut health - Transition from Spacelab to Space Station Freedom

NASA Technical Reports Server (NTRS)

Garshnek, V.; Ballard, R. W.

1993-01-01

Maintaining astronaut health is a critical aspect of human space exploration. Three decades of space research have demonstrated that microgravity produces significant physiological changes in astronauts. For long-duration missions, the possibility exists that these changes may prevent the achievement of full health and safety and may therefore require countermeasures. Meeting this goal depends on a strong biomedical foundation. Although much research is conducted with humans, some of the most critical work involves a necessary in-depth look into complex problem areas requiring invasive procedures using animals. Much of this research cannot be performed in humans within the bounds of accepted medical practice. A large portion of knowledge and experience in flying animals and applying the data to astronaut health has been obtained through the Spacelab experience and can be applied to a space station situation (expanded to accommodate necessary standardization and flexibility). The objectives of this paper are to (a) discuss the value and potential of animal research in answering critical questions to enable astronaut health for advanced missions, (b) discuss how previous Spacelab operational experience in animal studies can be applied to facilitate transition into a space station era, and (c) review capabilities of biological facilities projected for Space Station Freedom.

Exercise and pharmacological countermeasures for bone loss during long-duration space flight.

PubMed

Cavanagh, Peter R; Licata, Angelo A; Rice, Andrea J

2005-06-01

Bone loss in the lower extremities and lumbar spine is an established consequence of long-duration human space flight. Astronauts typically lose as much bone mass in the proximal femur in 1 month as postmenopausal women on Earth lose in 1 year. Pharmacological interventions have not been routinely used in space, and countermeasure programs have depended solely upon exercise. However, it is clear that the osteogenic stimulus from exercise has been inadequate to maintain bone mass, due to insufficient load or duration. Attention has therefore been focused on several pharmacological interventions that have been successful in preventing or attenuating osteoporosis on Earth. Anti-resorptives are the class of drugs most commonly used to treat osteoporosis in postmenopausal women, notably alendronate sodium, risedronate sodium, zoledronic acid, and selective estrogen receptor modulators, such as raloxifene. There has also been considerable recent interest in anabolic agents such as parathyroid hormone (PTH) and teriparatide (rhPTH [1-34]). Vitamin D and calcium supplementation have also been used. Recent studies of kindreds with abnormally high bone mineral density have provided insight into the genetic regulation of bone mass. This has led to potential therapeutic interventions based on the LRP5, Wnt and BMP2 pathways. Another target is the RANK-L/osteoprotegerin signaling pathway, which influences bone turnover by regulating osteoclast formation and maturation. Trials using such therapies in space are being planned. Among the factors to be considered are dose-response relationships, bone quality, post-use recovery, and combination therapies--all of which may have unique characteristics when the drugs are used in space.

Exercise and pharmacological countermeasures for bone loss during long-duration space flight

NASA Technical Reports Server (NTRS)

Cavanagh, Peter R.; Licata, Angelo A.; Rice, Andrea J.

2005-01-01

Bone loss in the lower extremities and lumbar spine is an established consequence of long-duration human space flight. Astronauts typically lose as much bone mass in the proximal femur in 1 month as postmenopausal women on Earth lose in 1 year. Pharmacological interventions have not been routinely used in space, and countermeasure programs have depended solely upon exercise. However, it is clear that the osteogenic stimulus from exercise has been inadequate to maintain bone mass, due to insufficient load or duration. Attention has therefore been focused on several pharmacological interventions that have been successful in preventing or attenuating osteoporosis on Earth. Anti-resorptives are the class of drugs most commonly used to treat osteoporosis in postmenopausal women, notably alendronate sodium, risedronate sodium, zoledronic acid, and selective estrogen receptor modulators, such as raloxifene. There has also been considerable recent interest in anabolic agents such as parathyroid hormone (PTH) and teriparatide (rhPTH [1-34]). Vitamin D and calcium supplementation have also been used. Recent studies of kindreds with abnormally high bone mineral density have provided insight into the genetic regulation of bone mass. This has led to potential therapeutic interventions based on the LRP5, Wnt and BMP2 pathways. Another target is the RANK-L/osteoprotegerin signaling pathway, which influences bone turnover by regulating osteoclast formation and maturation. Trials using such therapies in space are being planned. Among the factors to be considered are dose-response relationships, bone quality, post-use recovery, and combination therapies--all of which may have unique characteristics when the drugs are used in space.

Human spaceflight in the UK: the cost of non-participation

NASA Astrophysics Data System (ADS)

Fong, Kevin

2004-06-01

Human space exploration is not considered a strategic priority in the United Kingdom at present. However the UK would benefit from participating in human spaceflight, for both scientific and social reasons. From the point of view of medical science there are many parallels between the physiology of spaceflight and terrestrial disease processes, and studies of the response of astronauts to long-duration spaceflight can therefore help in the development of therapeutic strategies on Earth. On the social side, human spaceflight is an attractive vehicle for stimulating the interest of young people in science and engineering, something that must be of value for an aspiring ‘knowledge-based’ economy.

Effect of Real and Simulated Microgravity on Muscle Function

NASA Technical Reports Server (NTRS)

1997-01-01

In this session, Session JA3, the discussion focuses on the following topics: Changes in Calf Muscle Performance, Energy Metabolism, and Muscle Volume Caused by Long Term Stay on Space Station MIR; Vibrografic Signs of Autonomous Muscle Tone Studied in Long Term Space Missions; Reduction of Muscle Strength After Long Duration Space Flights is Associated Primarily with Changes in Neuromuscular Function; The Effects of a 115-Day Spaceflight on Neuromuscular Function in Crewman; Effects of 17-Day Spaceflight on Human Triceps Surae Electrically-Evoked Contractions; Effects of Muscle Unloading on EMG Spectral Parameters; and Myofiber Wound-Mediated FGF Release and Muscle Atrophy During Bedrest.

Spaceflight and immune responses of Rhesus monkeys

NASA Technical Reports Server (NTRS)

Sonnenfeld, Gerald

1994-01-01

Evidence from both human and rodent studies indicates that alterations in immunological parameters occur after space flight. The objective of this project is to determine the effects of space flight on immune responses of Rhesus monkeys. The expected significance of the work is a determination of the range of immunological functions of the Rhesus monkey, a primate similar in many ways to man, affected by space flight. Changes in immune responses that could yield alterations in resistance to infection may be determined as well as the duration of alterations in immune responses. Additional information on the nature of cellular interactions for the generation of immune responses may also be obtained.

Critical Need for Radiation Damage Tools for Space Missions

NASA Astrophysics Data System (ADS)

Tripathi, Ram

2005-04-01

NASA has a new vision for space exploration in the 21st Century encompassing a broad range of human and robotic missions including missions to Moon, Mars and beyond. As a result, there is a focus on long duration space missions. NASA, as much as ever, is committed to the safety of the missions and the crew. Exposure from the hazards of severe space radiation in deep space long duration missions is `the show stopper.' Thus, protection from the hazards of severe space radiation is of paramount importance for the new vision. There is an overwhelming emphasis on the reliability issues for the mission and the habitat. Accurate risk assessments critically depend on the accuracy of the input information about the interaction of ions with materials, electronics and tissues. A huge amount of essential experimental information for all the ions in space, across the periodic table, for a wide range of energies of several (up to a Trillion) orders of magnitude are needed for the radiation protection engineering for space missions that is simply not available (due to the high costs) and probably never will be. Therefore, there is a compelling need to develop reliable accurate models of nuclear reactions and structures that form the basic input ingredients. State-of-the-art nuclear cross sections models have been developed at the NASA Langley Research Center, however a considerable number of tools need to be developed to alleviate the situation. The vital role and importance of nuclear physics for space missions will be discussed.

Development of Bioregenerative Life Support for Longer Missions: When Can Plants Begin to Contribute to Atmospheric Management?

NASA Technical Reports Server (NTRS)

Wheeler, Raymond M.

2015-01-01

Through photosynthesis, plants can be used to generate oxygen and food for life support in human exploration of space. Initial contributions of plants to life support would likely occur through the production of supplemental, fresh foods. For plants to provide significant contributions to oxygen production, larger areas and significant lighting would be needed. An area of 10 m2 of plants with moderate lighting could provide about 13 of a human's oxygen needs. As mission distances and durations increase, plant growing areas could be expanded to assume more of the human life support needs.

Hardware development process for Human Research facility applications

NASA Astrophysics Data System (ADS)

Bauer, Liz

2000-01-01

The simple goal of the Human Research Facility (HRF) is to conduct human research experiments on the International Space Station (ISS) astronauts during long-duration missions. This is accomplished by providing integration and operation of the necessary hardware and software capabilities. A typical hardware development flow consists of five stages: functional inputs and requirements definition, market research, design life cycle through hardware delivery, crew training, and mission support. The purpose of this presentation is to guide the audience through the early hardware development process: requirement definition through selecting a development path. Specific HRF equipment is used to illustrate the hardware development paths. .

Neuroscience discipline science plan

NASA Technical Reports Server (NTRS)

1991-01-01

Over the past two decades, NASA's efforts in the neurosciences have developed into a program of research directed at understanding the acute changes that occur in the neurovestibular and sensorimotor systems during short-duration space missions. However, the proposed extended-duration flights of up to 28 days on the Shuttle orbiter and 6 months on Space Station Freedom, a lunar outpost, and Mars missions of perhaps 1-3 years in space, make it imperative that NASA's Life Sciences Division begin to concentrate research in the neurosciences on the chronic effects of exposure to microgravity on the nervous system. Major areas of research will be directed at understanding (1) central processing, (2) motor systems, (3) cognitive/spatial orientation, and (4) sensory receptors. The purpose of the Discipline Science Plan is to provide a conceptual strategy for NASA's Life Sciences Division research and development activities in the comprehensive area of neurosciences. It covers the significant research areas critical to NASA's programmatic requirements for the Extended-Duration Orbiter, Space Station Freedom, and exploration mission science activities. These science activities include ground-based and flight; basic, applied, and operational; and animal and human research and development. This document summarizes the current status of the program, outlines available knowledge, establishes goals and objectives, identifies science priorities, and defines critical questions in the subdiscipline areas of nervous system function. It contains a general plan that will be used by NASA Headquarters Program Offices and the field centers to review and plan basic, applied, and operational intramural and extramural research and development activities in this area.

Composting in advanced life support systems

NASA Technical Reports Server (NTRS)

Atkinson, C. F.; Sager, J. C.; Alazraki, M.; Loader, C.

1998-01-01

Space missions of extended duration are currently hampered by the prohibitive costs of external resupply. To reduce the need for resupply, the National Aeronautics and Space Administration (NASA) is currently testing methods to recycle solid wastes, water, and air. Composting can be an integral part of a biologically based waste treatment/recycling system. Results indicate that leachate from composted plant wastes is not inhibitory to seed germination and contains sufficient inorganic minerals to support plant growth. Other solid wastes, for example kitchen (food) wastes and human solid wastes, can be composted with inedible plant residues to safely reduce the volume of the wastes and levels of microorganisms potentially pathogenic to humans. Finished compost could serve as a medium for plant growth or mushroom production.

Composting in advanced life support systems.

PubMed

Atkinson, C F; Sager, J C; Alazraki, M; Loader, C

1998-01-01

Space missions of extended duration are currently hampered by the prohibitive costs of external resupply. To reduce the need for resupply, the National Aeronautics and Space Administration (NASA) is currently testing methods to recycle solid wastes, water, and air. Composting can be an integral part of a biologically based waste treatment/recycling system. Results indicate that leachate from composted plant wastes is not inhibitory to seed germination and contains sufficient inorganic minerals to support plant growth. Other solid wastes, for example kitchen (food) wastes and human solid wastes, can be composted with inedible plant residues to safely reduce the volume of the wastes and levels of microorganisms potentially pathogenic to humans. Finished compost could serve as a medium for plant growth or mushroom production.

Light and color as biological stimuli for the well-being in space long duration missions.

NASA Astrophysics Data System (ADS)

Schlacht, I.; Masali, M.; Ferrino, M.

Foreword In a microgravitational space environment the human biorhythm its sensory perception and all its psycho-physiological system comes completely upset by the absence of gravity and of external terrestrial references beyond the effects of constraint in a limited space This type of environment is defined extreme confined In order to create a human centered design in sight of missions of long duration We will have to consider above all these factors in order to try to increase the well-being the comfort and the productivity of the astronauts In this context we have elaborated a design concept that forecasts to resume the variety and the variability of the terrestrial stimuli through factors like the light and the color so as to recreate the input of the normal circadian cycle subsubsection Light and color and psycho-physiological well-being The human circadian rhythms day all around cycle of the organism s function are regulated by a sort of biological clock presumably localized in the hypothalamus The more obvious examples of this clock are the heartbeat the menstrual cycle the variation of the body temperature and the hormonal production during the day the behavior of plants and animals Those organism functions are influenced by the variation of the light around of the 24 hours The emission of an environmental light can restore sout s the earthly solar cycle irradiating the subject with the same frequency beams present on the Earth this irradiation should vary the intensity during the day like the

Light and color as biological stimuli for the well-being in space long duration missions

NASA Astrophysics Data System (ADS)

Schlacht, S.; Masali, M.; Musso, M.

Foreword In a microgravitational space environment the human biorhythm its sensory perception and all its psycho-physiological system comes completely upset by the absence of gravity and of external terrestrial references beyond the effects of constraint in a limited space This type of environment is defined extreme confined In order to create a human centered design in sight of missions of long duration We will have to consider above all these factors in order to try to increase the well-being the comfort and the productivity of the astronauts In this context we have elaborated a design concept that forecasts to resume the variety and the variability of the terrestrial stimuli through factors like the light and the color so as to recreate the input of the normal circadian cycle subsubsection Light and color and psycho-physiological well-being The human circadian rhythms day all around cycle of the organism s function are regulated by a sort of biological clock presumably localized in the hypothalamus The more obvious examples of this clock are the heartbeat the menstrual cycle the variation of the body temperature and the hormonal production during the day the behavior of plants and animals Those organism functions are influenced by the variation of the light around of the 24 hours The emission of an environmental light can restore sout s the earthly solar cycle irradiating the subject with the same frequency beams present on the Earth this irradiation should vary the intensity during the day like the

Wakata and Thirsk with MELFI in KIBO

NASA Image and Video Library

2009-06-15

ISS020-E-010025 (15 June 2009) --- Japan Aerospace Exploration Agency (JAXA) astronaut Koichi Wakata, Expedition 20 flight engineer, removes a dewar tray from the Minus Eighty Laboratory Freezer for ISS (MELFI) in order to insert biological samples into the trays in the Kibo laboratory of the International Space Station. Samples were taken as part of the Nutritional Status Assessment (Nutrition) with Repository experiment, a study done by NASA to date of human physiologic changes during long-duration spaceflight. Canadian Space Agency astronaut Robert Thirsk, flight engineer, assisted Wakata.

NASA Health and Human Performance in Spaceflight

NASA Technical Reports Server (NTRS)

Antonsen, Erik

2017-01-01

NASA, because of its mission and history, has tended to be an insular organization dominated by traditional engineering. Because of the engineering problems associated with early space endeavors, the historical approach to solving problems has been that of engineering. Long duration space travel will require a different approach, one requiring wider participation of those with expertise in divergent, emerging, and evolving fields. NASA has only recently begun to recognize this insufficiency and to reach out to communities, both domestic and international, to gain expertise on how to remedy it.

Integrated System Design for Air Revitalization in Next Generation Crewed Spacecraft

NASA Technical Reports Server (NTRS)

Mulloth, Lila; Perry, Jay; LeVan, Douglas

2004-01-01

The capabilities of NASA's existing environmental control and life support (ECLS) system designs are inadequate for future human space initiatives that involve long-duration space voyages and interplanetary missions. This paper discusses the concept of an integrated system of CO2 removal and trace contaminant control units that utilizes novel gas separation and purification techniques and optimized thermal and mechanical design, for future spacecraft. The integration process will enhance the overall life and economics of the existing systems by eliminating multiple mechanical devices with moving parts.

Human Research Program Integrated Research Plan. Revision A January 2009

NASA Technical Reports Server (NTRS)

2009-01-01

The Integrated Research Plan (IRP) describes the portfolio of Human Research Program (HRP) research and technology tasks. The IRP is the HRP strategic and tactical plan for research necessary to meet HRP requirements. The need to produce an IRP is established in HRP-47052, Human Research Program - Program Plan, and is under configuration management control of the Human Research Program Control Board (HRPCB). Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological and behavioral effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes HRP s approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and how they are integrated to provide a risk mitigation tool. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

Towards human exploration of space: The THESEUS review series on immunology research priorities

PubMed Central

Frippiat, Jean-Pol; Crucian, Brian E; de Quervain, Dominique J-F; Grimm, Daniela; Montano, Nicola; Praun, Siegfried; Roozendaal, Benno; Schelling, Gustav; Thiel, Manfred; Ullrich, Oliver; Choukèr, Alexander

2016-01-01

Dysregulation of the immune system occurs during spaceflight and may represent a crew health risk during exploration missions because astronauts are challenged by many stressors. Therefore, it is crucial to understand the biology of immune modulation under spaceflight conditions in order to be able to maintain immune homeostasis under such challenges. In the framework of the THESEUS project whose aim was to develop an integrated life sciences research roadmap regarding human space exploration, experts working in the field of space immunology, and related disciplines, established a questionnaire sent to scientists around the world. From the review of collected answers, they deduced a list of key issues and provided several recommendations such as a maximal exploitation of currently available resources on Earth and in space, and to increase increments duration for some ISS crew members to 12 months or longer. These recommendations should contribute to improve our knowledge about spaceflight effects on the immune system and the development of countermeasures that, beyond astronauts, could have a societal impact. PMID:28725745

Towards human exploration of space: The THESEUS review series on immunology research priorities.

PubMed

Frippiat, Jean-Pol; Crucian, Brian E; de Quervain, Dominique J-F; Grimm, Daniela; Montano, Nicola; Praun, Siegfried; Roozendaal, Benno; Schelling, Gustav; Thiel, Manfred; Ullrich, Oliver; Choukèr, Alexander

2016-01-01

Dysregulation of the immune system occurs during spaceflight and may represent a crew health risk during exploration missions because astronauts are challenged by many stressors. Therefore, it is crucial to understand the biology of immune modulation under spaceflight conditions in order to be able to maintain immune homeostasis under such challenges. In the framework of the THESEUS project whose aim was to develop an integrated life sciences research roadmap regarding human space exploration, experts working in the field of space immunology, and related disciplines, established a questionnaire sent to scientists around the world. From the review of collected answers, they deduced a list of key issues and provided several recommendations such as a maximal exploitation of currently available resources on Earth and in space, and to increase increments duration for some ISS crew members to 12 months or longer. These recommendations should contribute to improve our knowledge about spaceflight effects on the immune system and the development of countermeasures that, beyond astronauts, could have a societal impact.

The Effects of the Mars Exploration Rovers (MER) Work Schedule Regime on Locomotor Activity Circadian Rhythms, Sleep and Fatigue

NASA Technical Reports Server (NTRS)

DeRoshia, Charles W.; Colletti, Laura C.; Mallis, Melissa M.

2008-01-01

This study assessed human adaptation to a Mars sol by evaluating sleep metrics obtained by actigraphy and subjective responses in 22 participants, and circadian rhythmicity in locomotor activity in 9 participants assigned to Mars Exploration Rover (MER) operational work schedules (24.65 hour days) at the Jet Propulsion Laboratory in 2004. During MER operations, increased work shift durations and reduced sleep durations and time in bed were associated with the appearance of pronounced 12-hr (circasemidian) rhythms with reduced activity levels. Sleep duration, workload, and circadian rhythm stability have important implications for adaptability and maintenance of operational performance not only of MER operations personnel but also in space crews exposed to a Mars sol of 24.65 hours during future Mars missions.

Teleoperation support for early human planetary missions.

PubMed

Genta, Giancarlo; Perino, Maria Antonietta

2005-12-01

A renewed interest in human exploration is flourishing among all the major spacefaring nations. In fact, in the complex scene of planned future space activities, the development of a Moon base and the human exploration of Mars might have the potential to renew the enthusiasm in expanding the human presence beyond the boundaries of Earth. Various initiatives have been undertaken to define scenarios and identify the required infrastructures and related technology innovations. The typical proposed approach follows a multistep strategy, starting with a series of precursor robotic missions to acquire further knowledge of the planet and to select the best potential landing sites, and evolving toward more demanding missions for the development of a surface infrastructure necessary to sustain human presence. The technologies involved in such a demanding enterprise range from typical space technologies, like transportation and propulsion, automation and robotics, rendezvous and docking, entry/reentry, aero-braking, navigation, and deep space communications, to human-specific issues like physiology, psychology, behavioral aspects, and nutritional science for long-duration exposure, that go beyond the traditional boundaries of space activities. Among the required elements to support planetary exploration, both for the precursor robotic missions and to sustain human exploration, rovers and trucks play a key role. A robust level of autonomy will need to be secured to perform preplanned operations, particularly for the surface infrastructure development, and a teleoperated support, either from Earth or from a local base, will enhance the in situ field exploration capability.

In-Space Crew-Collaborative Task Scheduling

NASA Technical Reports Server (NTRS)

Jaap, John; Meyer, Patrick; Davis, Elizabeth; Richardson, Lea

2007-01-01

For all past and current human space missions, the final scheduling of tasks to be done in space has been devoid of crew control, flexibility, and insight. Ground controllers, with minimal input from the crew, schedule the tasks and uplink the timeline to the crew or uplink the command sequences to the hardware. Prior to the International Space Station (ISS), the crew could make requests about tomorrow s timeline, they could omit a task, or they could request that something in the timeline be delayed. This lack of control over one's own schedule has had negative consequences. There is anecdotal consensus among astronauts that control over their own schedules will mitigate the stresses of long duration missions. On ISS, a modicum of crew control is provided by the job jar. Ground controllers prepare a task list (a.k.a. "job jar") of non-conflicting tasks from which jobs can be chosen by the in space crew. Because there is little free time and few interesting non-conflicting activities, the task-list approach provides little relief from the tedium of being micro-managed by the timeline. Scheduling for space missions is a complex and laborious undertaking which usually requires a large cadre of trained specialists and suites of complex software tools. It is a giant leap from today s ground prepared timeline (with a job jar) to full crew control of the timeline. However, technological advances, currently in-work or proposed, make it reasonable to consider scheduling a collaborative effort by the ground-based teams and the in-space crew. Collaboration would allow the crew to make minor adjustments, add tasks according to their preferences, understand the reasons for the placement of tasks on the timeline, and provide them a sense of control. In foreseeable but extraordinary situations, such as a quick response to anomalies and extended or unexpected loss of signal, the crew should have the autonomous ability to make appropriate modifications to the timeline, extend the timeline, or even start over with a new timeline. The Vision for Space Exploration (VSE), currently being pursued by the National Aeronautics and Space Administration (NASA), will send humans to Mars in a few decades. Stresses on the human mind will be exacerbated by the longer durations and greater distances, and it will be imperative to implement stress-reducing innovations such as giving the crew control of their daily activities.

The Impact of Apollo-Era Microbiology on Human Space Flight

NASA Technical Reports Server (NTRS)

Elliott, T. F; Castro, V. A.; Bruce, R. J.; Pierson, D. L.

2014-01-01

The microbiota of crewmembers and the spacecraft environment contributes significant risk to crew health during space flight missions. NASA reduces microbial risk with various mitigation methods that originated during the Apollo Program and continued to evolve through subsequent programs: Skylab, Shuttle, and International Space Station (ISS). A quarantine of the crew and lunar surface samples, within the Lunar Receiving Laboratory following return from the Moon, was used to prevent contamination with unknown extraterrestrial organisms. The quarantine durations for the crew and lunar samples were 21 days and 50 days, respectively. A series of infections among Apollo crewmembers resulted in a quarantine before launch to limit exposure to infectious organisms. This Health Stabilization Program isolated the crew for 21 days before flight and was effective in reducing crew illness. After the program developed water recovery hardware for Apollo spacecraft, the 1967 National Academy of Science Space Science Board recommended the monitoring of potable water. NASA implemented acceptability limits of 10 colony forming units (CFU) per mL and the absence of viable E. coli, anaerobes, yeasts, and molds in three separate 150 mL aliquots. Microbiological investigations of the crew and spacecraft environment were conducted during the Apollo program, including the Apollo-Soyuz Test Project and Skylab. Subsequent space programs implemented microbial screening of the crew for pathogens and acceptability limits on spacecraft surfaces and air. Microbiology risk mitigation methods have evolved since the Apollo program. NASA cancelled the quarantine of the crew after return from the lunar surface, reduced the duration of the Health Stabilization Program; and implemented acceptability limits for spacecraft surfaces and air. While microbial risks were not a main focus of the early Mercury and Gemini programs, the extended duration of Apollo flights resulted in the increased scrutiny of impact of the space flight environment on crew health. The lessons learned during that era of space flight continue to impact microbiology risk mitigation in space programs today.

Experimental And Numerical Evaluation Of Gaseous Agents For Suppressing Cup-Burner Flames In Low Gravity

NASA Technical Reports Server (NTRS)

Takahashi, Fumiaki; Linteris, Gregory T.; Katta, Viswanath R.

2003-01-01

Longer duration missions to the moon, to Mars, and on the International Space Station (ISS) increase the likelihood of accidental fires. NASA's fire safety program for human-crewed space flight is based largely on removing ignition sources and controlling the flammability of the material on-board. There is ongoing research to improve the flammability characterization of materials in low gravity; however, very little research has been conducted on fire suppression in the low-gravity environment. Although the existing suppression systems aboard the Space Shuttle (halon 1301, CF3Br) and the ISS (CO2 or water-based form) may continue to be used, alternative effective agents or techniques are desirable for long-duration missions. The goal of the present investigation is to: (1) understand the physical and chemical processes of fire suppression in various gravity and O2 levels simulating spacecraft, Mars, and moon missions; (2) provide rigorous testing of analytical models, which include detailed combustion-suppression chemistry and radiation sub-models, so that the model can be used to interpret (and predict) the suppression behavior in low gravity; and (3) provide basic research results useful for advances in space fire safety technology, including new fire-extinguishing agents and approaches.

Radiation shielding materials characterization in the MoMa-Count program and further evolutions

NASA Astrophysics Data System (ADS)

Lobascio, Cesare

In the frame of the space research programme MoMa (From Molecules to Man) -Count (Coun-termeasures), funded by the Italian Space Agency, multi-functional protections for human space exploration have been investigated, paying particular attention to flexible materials, selected also for their excellent structural, thermal and ballistic performances. Flexible materials such as Kevlar R are qualified for space application, but have poorly known space radiation prop-erties, with consequent uncertainties about their shielding efficiency against the radiation en-vironment. The necessary evaluation of their shielding efficiency has been chiefly based on dedicated ground experiments in accelerators, supplemented by Monte Carlo simulations of the particle transport in the materials or multi-layers. In addition, flight experiments have been performed in Low Earth Orbit (LEO), onboard the International Space Station (ISS) and the re-entry capsule Foton, to measure the shielding behaviour in the actual operating environment of space, via dedicated detectors and dosimeters. This paper aims at presenting the results and lessons learned accrued within the MoMa-Count program, as well as the future actions planned for improving radiation shielding in long duration human exploration missions.

NASA Biological Specimen Repository

NASA Technical Reports Server (NTRS)

Pietrzyk, Robert; McMonigal, K. A.; Sams, C. F.; Johnson, M. A.

2009-01-01

The NASA Biological Specimen Repository (NBSR) has been established to collect, process, annotate, store, and distribute specimens under the authority of the NASA/JSC Committee for the Protection of Human Subjects. The International Space Station (ISS) provides a platform to investigate the effects of microgravity on human physiology prior to lunar and exploration class missions. The NBSR is a secure controlled storage facility that is used to maintain biological specimens over extended periods of time, under well-controlled conditions, for future use in approved human spaceflight-related research protocols. The repository supports the Human Research Program, which is charged with identifying and investigating physiological changes that occur during human spaceflight, and developing and implementing effective countermeasures when necessary. The storage of crewmember samples from many different ISS flights in a single repository will be a valuable resource with which researchers can validate clinical hypotheses, study space-flight related changes, and investigate physiological markers All samples collected require written informed consent from each long duration crewmember. The NBSR collects blood and urine samples from all participating long duration ISS crewmembers. These biological samples are collected pre-flight at approximately 45 days prior to launch, during flight on flight days 15, 30, 60 120 and within 2 weeks of landing. Postflight sessions are conducted 3 and 30 days following landing. The number of inflight sessions is dependent on the duration of the mission. Operations began in 2007 and as of October 2009, 23 USOS crewmembers have completed or agreed to participate in this project. As currently planned, these human biological samples will be collected from crewmembers covering multiple ISS missions until the end of U.S. presence on the ISS or 2017. The NBSR will establish guidelines for sample distribution that are consistent with ethical principles, protection of crewmember confidentiality, prevailing laws and regulations, intellectual property policies, and consent form language. A NBSR Advisory Board composed of representatives of all participating agencies will be established to evaluate each request by an investigator for use of the samples to ensure the request reflects the mission of the NBSR.

Quantifying multi-dimensional attributes of human activities at various geographic scales based on smartphone tracking.

PubMed

Zhou, Xiaolu; Li, Dongying

2018-05-09

Advancement in location-aware technologies, and information and communication technology in the past decades has furthered our knowledge of the interaction between human activities and the built environment. An increasing number of studies have collected data regarding individual activities to better understand how the environment shapes human behavior. Despite this growing interest, some challenges exist in collecting and processing individual's activity data, e.g., capturing people's precise environmental contexts and analyzing data at multiple spatial scales. In this study, we propose and implement an innovative system that integrates smartphone-based step tracking with an app and the sequential tile scan techniques to collect and process activity data. We apply the OpenStreetMap tile system to aggregate positioning points at various scales. We also propose duration, step and probability surfaces to quantify the multi-dimensional attributes of activities. Results show that, by running the app in the background, smartphones can measure multi-dimensional attributes of human activities, including space, duration, step, and location uncertainty at various spatial scales. By coordinating Global Positioning System (GPS) sensor with accelerometer sensor, this app can save battery which otherwise would be drained by GPS sensor quickly. Based on a test dataset, we were able to detect the recreational center and sports center as the space where the user was most active, among other places visited. The methods provide techniques to address key issues in analyzing human activity data. The system can support future studies on behavioral and health consequences related to individual's environmental exposure.

Enhancing Arctic Surveillance With Space-Based Radars

DTIC Science & Technology

2013-06-01

shipping, hydrocarbon extraction, fishing, and tourism activities (to name but just a few) are increasing in frequency, duration, and intensity and...maritime activities in the Arctic Circle ranging from relatively benign tourism ventures to adversary naval combatant maneuvers, the United States...activities there (U.S. Northern Command Posture Statement, 2011). Without awareness of human activities such as shipping, tourism , military operations

Effects of Spaceflight on Astronaut Brain Structure as Indicated on MRI.

PubMed

Roberts, Donna R; Albrecht, Moritz H; Collins, Heather R; Asemani, Davud; Chatterjee, A Rano; Spampinato, M Vittoria; Zhu, Xun; Chimowitz, Marc I; Antonucci, Michael U

2017-11-02

There is limited information regarding the effects of spaceflight on the anatomical configuration of the brain and on cerebrospinal fluid (CSF) spaces. We used magnetic resonance imaging (MRI) to compare images of 18 astronauts' brains before and after missions of long duration, involving stays on the International Space Station, and of 16 astronauts' brains before and after missions of short duration, involving participation in the Space Shuttle Program. Images were interpreted by readers who were unaware of the flight duration. We also generated paired preflight and postflight MRI cine clips derived from high-resolution, three-dimensional imaging of 12 astronauts after long-duration flights and from 6 astronauts after short-duration flights in order to assess the extent of narrowing of CSF spaces and the displacement of brain structures. We also compared preflight ventricular volumes with postflight ventricular volumes by means of an automated analysis of T 1 -weighted MRIs. The main prespecified analyses focused on the change in the volume of the central sulcus, the change in the volume of CSF spaces at the vertex, and vertical displacement of the brain. Narrowing of the central sulcus occurred in 17 of 18 astronauts after long-duration flights (mean flight time, 164.8 days) and in 3 of 16 astronauts after short-duration flights (mean flight time, 13.6 days) (P<0.001). Cine clips from a subgroup of astronauts showed an upward shift of the brain after all long-duration flights (12 astronauts) but not after short-duration flights (6 astronauts) and narrowing of CSF spaces at the vertex after all long-duration flights (12 astronauts) and in 1 of 6 astronauts after short-duration flights. Three astronauts in the long-duration group had optic-disk edema, and all 3 had narrowing of the central sulcus. A cine clip was available for 1 of these 3 astronauts, and the cine clip showed upward shift of the brain. Narrowing of the central sulcus, upward shift of the brain, and narrowing of CSF spaces at the vertex occurred frequently and predominantly in astronauts after long-duration flights. Further investigation, including repeated postflight imaging conducted after some time on Earth, is required to determine the duration and clinical significance of these changes. (Funded by the National Aeronautics and Space Administration.).

Crew Health and Performance on Mars

NASA Technical Reports Server (NTRS)

Stegemoeller, Charlie

1998-01-01

The issues surrounding the health and performance on Mars of a human crew are discussed in this presentation. The work of Human Space Life Sciences Program Office (HSLSPO) in the preparation of a crew for a Martian mission is reviewed. This includes a review of issues relating to human health and performance (HHP) in space and microgravity. The Mars design reference mission requires the most rigorous life sciences critical path of any manned mission in the forseeable future. This mission will require a 30 months round trip, with 4 different transistions to different gravities, and two episodes of high gravity load, during the Mars and Earth Aerobraking exercises. A graph is presented which shows the number of subjects with human space flight experience greater than 30 days. A chart presents the physical challenges to HHP in terms of gravity and acceleration and the length of times the crew will be exposed to the various gravity loads. Another chart presents the radiation challenges to the HHP for the duration of the trip. The human element is the most complex element of the mission design. Some challenges (i.e., human engineering and life support) must be overcome, and some issues such as bone loss, and radiation exposure must be addressed prior to making a decision for a manned Martian mission.

The Impact of Oxidative Stress on the Bone System in Response to the Space Special Environment.

PubMed

Tian, Ye; Ma, Xiaoli; Yang, Chaofei; Su, Peihong; Yin, Chong; Qian, Ai-Rong

2017-10-12

The space special environment mainly includes microgravity, radiation, vacuum and extreme temperature, which seriously threatens an astronaut's health. Bone loss is one of the most significant alterations in mammalians after long-duration habitation in space. In this review, we summarize the crucial roles of major factors-namely radiation and microgravity-in space in oxidative stress generation in living organisms, and the inhibitory effect of oxidative stress on bone formation. We discussed the possible mechanisms of oxidative stress-induced skeletal involution, and listed some countermeasures that have therapeutic potentials for bone loss via oxidative stress antagonism. Future research for better understanding the oxidative stress caused by space environment and the development of countermeasures against oxidative damage accordingly may facilitate human beings to live more safely in space and explore deeper into the universe.

The Impact of Oxidative Stress on the Bone System in Response to the Space Special Environment

PubMed Central

Tian, Ye; Ma, Xiaoli; Yang, Chaofei; Su, Peihong; Yin, Chong

2017-01-01

The space special environment mainly includes microgravity, radiation, vacuum and extreme temperature, which seriously threatens an astronaut’s health. Bone loss is one of the most significant alterations in mammalians after long-duration habitation in space. In this review, we summarize the crucial roles of major factors—namely radiation and microgravity—in space in oxidative stress generation in living organisms, and the inhibitory effect of oxidative stress on bone formation. We discussed the possible mechanisms of oxidative stress-induced skeletal involution, and listed some countermeasures that have therapeutic potentials for bone loss via oxidative stress antagonism. Future research for better understanding the oxidative stress caused by space environment and the development of countermeasures against oxidative damage accordingly may facilitate human beings to live more safely in space and explore deeper into the universe. PMID:29023398

@Astro_Wheels Tweetup

NASA Image and Video Library

2011-03-16

Astronaut Doug Wheelock discusses his experiences while living on the International Space Station during a tweetup at NASA Headquarters in Washington, Wednesday, March 16, 2011. Wheelock, who has accumulated a total of 178 days in space, assumed command of the International Space Station and the Expedition 25 crew. During Expedition 25, there were more than 120 microgravity experiments in human research; biology and biotechnology; physical and materials sciences; technology development; and Earth and space sciences. Wheelock also responded to an emergency shutdown of half of the station's external cooling system and supported three unplanned spacewalks to replace the faulty pump module that caused the shutdown. His efforts restored the station's critical cooling system to full function. The mission duration was 163 days. Photo Credit: (NASA/Paul E. Alers)

Will Astronauts Wash Clothes on the Way to Mars?

NASA Technical Reports Server (NTRS)

Ewert, Michael K.; Jeng, Frank F.

2015-01-01

Future human space exploration missions will lengthen to years, and keeping crews clothed without a huge resupply burden is an important consideration for habitation systems. A space laundry system could be the solution; however, the resources it uses must be accounted for and must win out over the reliable practice of simply bringing along enough spare underwear. NASA has conducted trade-off studies through its Logistics Reduction Project to compare current space clothing systems, life extension of that clothing, traditional water-based clothes washing, and other sanitizing techniques. The best clothing system depends on the mission and assumptions but, in general, analysis results indicate that washing clothes on space missions will start to pay off as mission durations approach a year.

Radiation Transport Modeling and Assessment to Better Predict Radiation Exposure, Dose, and Toxicological Effects to Human Organs on Long Duration Space Flights

NASA Technical Reports Server (NTRS)

Denkins, Pamela; Badhwar, Gautam; Obot, Victor

2000-01-01

NASA's long-range plans include possible human exploratory missions to the moon and Mars within the next quarter century. Such missions beyond low Earth orbit will expose crews to transient radiation from solar particle events which include high-energy galactic cosmic rays and high-energy protons. Because the radiation levels in space are high and the missions long, adequate shielding is needed to minimize the deleterious health effects of exposure to radiation. The focus of this study is radiation exposure to the blood-forming organs of the NASA astronauts. NASA/JSC developed the Phantom Torso Experiment for Organ Dose Measurements which housed active and passive dosimeters that would monitor and record absorbed radiation levels at vital organ locations. This experiment was conducted during the STS-9 I mission in May '98 and provided the necessary space radiation data for correlation to results obtained from the current analytical models used to predict exposure to the blood-forming organs. Numerous models (i.e., BRYNTRN and HZETRN) have been developed and used to predict radiation exposure. However, new models are continually being developed and evaluated. The Space Environment Information Systems (SPENVIS) modeling program, developed by the Belgian Institute for Space Aeronomy, is to be used and evaluated as a part of the research activity. It is the intent of this research effort to compare the modeled data to the findings from the STS-9 I mission; assess the accuracy and efficiency of this model; and to determine its usefulness for predicting radiation exposure and developing better guidelines for shielding requirements for long duration manned missions.

Cancer Risk Assessment for Space Radiation

NASA Technical Reports Server (NTRS)

Richmond, Robert C.; Curreri, Peter A. (Technical Monitor)

2002-01-01

Predicting the occurrence of human cancer following exposure to any agent causing genetic damage is a difficult task. This is because the uncertainty of uniform exposure to the damaging agent, and the uncertainty of uniform processing of that damage within a complex set of biological variables, degrade the confidence of predicting the delayed expression of cancer as a relatively rare event within any given clinically normal individual. The radiation health research priorities for enabling long-duration human exploration of space were established in the 1996 NRC Report entitled "Radiation Hazards to Crews of Interplanetary Missions: Biological Issues and Research Strategies". This report emphasized that a 15-fold uncertainty in predicting radiation-induced cancer incidence must be reduced before NASA can commit humans to extended interplanetary missions. That report concluded that the great majority of this uncertainty is biologically based, while a minority is physically based due to uncertainties in radiation dosimetry and radiation transport codes. Since that report, the biologically based uncertainty has remained large, and the relatively small uncertainty associated with radiation dosimetry has increased due to the considerations raised by concepts of microdosimetry. In a practical sense, however, the additional uncertainties introduced by microdosimetry are encouraging since they are in a direction of lowered effective dose absorbed through infrequent interactions of any given cell with the high energy particle component of space radiation. The biological uncertainty in predicting cancer risk for space radiation derives from two primary facts. 1) One animal tumor study has been reported that includes a relevant spectrum of particle radiation energies, and that is the Harderian gland model in mice. Fact #1: Extension of cancer risk from animal models, and especially from a single study in an animal model, to humans is inherently uncertain. 2) One human database is predominantly used for assessing cancer risk caused by space radiation, and that is the Japanese atomic bomb survivors. Fact #2: The atomic-bomb-survivor database, itself a remarkable achievement, contains uncertainties. These include the actual exposure to each individual, the radiation quality of that exposure, and the fact that the exposure was to acute doses of predominantly low-LET radiation, not to chronic exposures of high-LET radiation expected on long-duration interplanetary manned missions.

The Next Giant Leap: Human Exploration and Utilization of NEOs

NASA Astrophysics Data System (ADS)

Jones, T. D.; Vilas, F.; Love, S.; Hack, K.; Gefert, L.; Sykes, M. V.; Lewis, J. S.; Jedicke, R.; Davis, D.; Hartmann, W. K.; Farquhar, R.; McFadden, L.; Durda, D.

2001-11-01

Planetary science plays a unique role as the pathfinder for future human space activities beyond the International Space Station. It can also provide the rationale for the first human departure from LEO since the Apollo program. We are examining the potential for human missions to small near-Earth objects (typically tens of meters), passing close by the Earth-Moon system with very low delta-v. A preliminary estimate suggests there may be many thousands of these objects, raising the possibility of number of launch opportunities each year. To demonstrate feasibility, we have simulated a mission to 1991 VG during 1991/1992 when it passed within 0.004 AU of the Earth. This mission takes a total of 60 days, including a 30 day stay time at the asteroid. The accessibility of these targets may provide an opportunity to develop and test systems needed for longer duration interplanetary missions to Mars, and to engage in precursor space resource utilization activities. Early discovery, orbit determination, and target characterization should be pursued and spacebased and groundbased systems that would be needed assessed. Crewed missions would be preceded by robotic probes to test acquisition, rendezvous, and local operations while returning significant new science from target objects. As we look beyond ISS over the next decade, we must reinvigorate a mutually supportive relationship between our human space and solar system exploration goals. The scientific and exploration rationale for sending humans to NEOs must be mature to meet NASA's decision making window, now opening, for operations beyond near-Earth space.

Human subjects concerns in ground based ECLSS testing - Managing uncertainty in closely recycled systems

NASA Technical Reports Server (NTRS)

Crump, William J.; Janik, Daniel S.; Thomas, L. Dale

1990-01-01

U.S. space missions have to this point used water either made on board or carried from earth and discarded after use. For Space Station Freedom, long duration life support will include air and water recycling using a series of physical-chemical subsystems. The Environmental Control and Life Support System (ECLSS) designed for this application must be tested extensively at all stages of hardware maturity. Human test subjects are required to conduct some of these tests, and the risks associated with the use of development hardware must be addressed. Federal guidelines for protection of human subjects require careful consideration of risks and potential benefits by an Institutional Review Board (IRB) before and during testing. This paper reviews the ethical principles guiding this consideration, details the problems and uncertainties inherent in current hardware testing, and presents an incremental approach to risk assessment for ECLSS testing.

14 CFR 399.120 - Duration of certificates in limited-entry markets.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Duration of certificates in limited-entry markets. 399.120 Section 399.120 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... Certificate Duration § 399.120 Duration of certificates in limited-entry markets. All certificate authority...

Behavioral Issues Associated With Long Duration Space Expeditions: Review and Analysis of Astronaut Journals

NASA Technical Reports Server (NTRS)

Struster, Jack

2010-01-01

Personal journals maintained by NASA astronauts during six-month expeditions onboard the International Space Station were analyzed to obtain information concerning a wide range of behavioral and human factors issues. Astronauts wrote most about their work, followed by outside communications (with mission control, family, and friends), adjustment to the conditions, interactions with crew mates, recreation/leisure, equipment (installation, maintenance), events (launches, docking, hurricanes, etc.), organization/management, sleep, and food. The study found evidence of a decline in morale during the third quarters of the missions and identified key factors that contribute to sustained adjustment and optimal performance during long-duration space expeditions. Astronauts reported that they benefited personally from writing in their journals because it helped maintain perspective on their work and relations with others. Responses to questions asked before, during, and after the expeditions show that living and working onboard the ISS is not as difficult as the astronauts anticipate before starting their six-month tours of duty. Recommendations include application of study results and continuation of the experiment to obtain additional data as crew size increases and operations evolve.

Space Station as a Long Duration Exposure Facility

NASA Technical Reports Server (NTRS)

Folley, Adrienne; Scheib, Jim

1995-01-01

There is need for a space platform for experiments investigating long duration exposure to space. This platform should be maintainable in the event of a malfunction, and experiments should be easily recoverable for analysis on Earth. The International Space Station provides such a platform. The current Space Station configuration has six external experiment attachment sites, providing utilities and data support distributed along the external truss. There are also other sites that could potentially support long duration exposure experiments. This paper describes the resources provided to payloads at these sites, and cites examples of integration of proposed long duration exposure experiments on these sites. The environments to which external attached payloads will be exposed are summarized.

Plans and Recent Developments for Fluid Physics Experiments Aboard the ISS

NASA Technical Reports Server (NTRS)

McQuillen, John B.; Motil, Brian J.

2016-01-01

From the very first days of human spaceflight, NASA has been conducting experiments in space to understand the effect of weightlessness on physical and chemically reacting systems. NASA Glenn Research Center (GRC) in Cleveland, Ohio has been at the forefront of this research looking at both fundamental studies in microgravity as well as experiments targeted at reducing the risks to long duration human missions to the moon, Mars, and beyond. In the current International Space Station (ISS) era, we now have an orbiting laboratory that provides the highly desired condition of long-duration microgravity. This allows continuous and interactive research similar to Earth-based laboratories. Because of these capabilities, the ISS is an indispensable laboratory for low gravity research. NASA GRC has been actively involved in developing and operating facilities and experiments on the ISS since the beginning of a permanent human presence on November 2, 2000. As the lead Center for Fluid Physics, NASA GRC is developing and testing the Pack Bed Reactor Experiment (PBRE), Zero Boil Off (ZBOT) Two Phase Flow Separator Experiment (TPFSE), Multiphase Flow Heat Transfer (MFHT) Experiment and the Electro-HydroDynamic (EHD) experiment. An overview each experiment, including its objectives, concept and status will be presented. In addition, data will be made available after a nominal period to NASAs Physical Science Informatics PSI database to the scientific community to enable additional analyses of results.

International Space Station Human Behavior and Performance Competency Model: Volume I

NASA Technical Reports Server (NTRS)

Schmidt, Lacey

2008-01-01

This document defines Human Behavior and Performance (HBP) competencies that are recommended to be included as requirements to participate in international long duration missions. They were developed in response to the Multilateral Crew Operations Panel (MMOP) request to develop HBP training requirements for the International Space Station (ISS). The competency model presented here was developed by the ITCB HBPT WG and forms the basis for determining the HBP training curriculum for long duration crewmembers. This document lists specific HBP competencies and behaviors required of astronauts/cosmonauts who participate in ISS expedition and other international longduration missions. Please note that this model does not encompass all competencies required. For example, outside the scope of this document are cognitive skills and abilities, including but not limited to concentration, memorization, perception, imagination, and thinking. It is assumed that these skills, which are crucial in terms of human behavior and performance, are considered during selection phase since such professionally significant qualities of the operator should be taken into consideration in order to ensure sufficient baseline levels that can be further improved during general astronaut training. Also, technical competencies, even though critical for crewmembers, are beyond the scope of this document. It should also be noted that the competencies in this model (and subsequent objectives) are not intended to limit the internal activities or training programs of any international partner.

Design Considerations for Spacecraft Operations During Uncrewed Dormant Phases of Human Exploration Missions

NASA Technical Reports Server (NTRS)

Williams-Byrd, Julie; Antol, Jeff; Jefferies, Sharon; Goodliff, Kandyce; Williams, Phillip; Ambrose, Rob; Sylvester, Andre; Anderson, Molly; Dinsmore, Craig; Hoffman, Stephen;

"Light and color like biological stimuli for the well being in space long duration missions"

NASA Astrophysics Data System (ADS)

Schlacht, S.; Masali, M.; Ferrino, F.

Foreword In a microgravitational space environment the human biorhythm its sensory perception and all its psycho-physiological system comes completely upset by the absence of gravity and of external terrestrial references beyond the effects of constraint in a limited space This type of environment is defined like confined extreme In order to create a human centered design in sight of missions of long duration we will have to consider above all these factors in order to try to increase the wellbeing the comfort and the productivity of the astronauts In this context we have elaborated a design concept that forecasts to resume the variety and the variability of the terrestrial stimuli through factors like the light and the color so as to recreate the input of the normal circadian cycle subsubsection Light and color and psycho-physiological wellbeing In microgravity the inputs send from the organs that regulate the space orientation as the vestibular organ may go in conflict with the visual perception and create vary malarius The organism answers to these events making silent the information from these organs and giving the control to the information from the visual system For this reason it is necessary to use an immediate visual arrangement created according to instinctive answers to natural signals to which we are accustomed in the earthly life like the sky up and earth down The colors can guide the user to the orientation in the several functions through biological inputs active on the earth what is

Optimization of Martian regolith and ultra-high molecular weight polyethylene composites for radiation shielding and habitat structures

NASA Astrophysics Data System (ADS)

Wilkins, Richard; Gersey, Brad; Baburaj, Abhijit; Barnett, Milan; Zhou, Xianren

2012-07-01

In preparation for long duration missions to the moon, Mars or, even near earth asteroids, one challenge, amongst many others, that the space program faces is shielding against space radiation. It is difficult to effectively shield all sources of space radiation because of the broad range of types and high energies found in space, so the most important goal is to minimize the damaging effects that may occur to humans and electronics during long duration space flight. For a long duration planetary habitat, a shielding option is to use in situ resources such as the native regolith. A possible way to utilize regolith on a planet is to combine it with a binder to form a structural material that also exhibits desirable shielding properties. In our studies, we explore Martian regolith and ultra-high molecular weight polyethylene (UHMWPE) composites. We selected UHMWPE as the binder in our composites due to its high hydrogen content; a desirable characteristic for shielding materials in a space environment. Our initial work has focused on the process of developing the right ratio of simulated Martian regolith and UHMWPE to yield the best results in material endurance and strength, while retaining good shielding characteristics. Another factor in our optimization process is to determine the composite ratio that minimizes the amount of ex situ UHMWPE while retaining desirable structural and shielding properties. This consideration seeks to minimize mission weight and costs. Mechanical properties such as tensile strength of the Martian regolith/UHMWPE composite as a function of its grain size, processing parameters, and different temperature variations used are discussed. The radiation shielding effectiveness of loose mixtures of Martian regolith/ UHMWPE is evaluated using a 200 MeV proton beam and a tissue equivalent proportional counter. Preliminary results show that composites with an 80/20 ratio percent weight of regolith to UHMWPE can be fabricated with potentially useful structural strength. I n addition, Martian regolith, while not as efficient as polyethylene at reducing proton energy as a function of shield thickness, compares well with polyethylene at shielding the 200 MeV protons. These preliminary results indicate that native Martian regolith has promising properties as a habitat material for future human missions. Future work studying the shielding effectiveness and radiation tolerance will also be discussed.

Prisms to travel in time: Investigation of time-space association through prismatic adaptation effect on mental time travel.

PubMed

Anelli, Filomena; Ciaramelli, Elisa; Arzy, Shahar; Frassinetti, Francesca

2016-11-01

Accumulating evidence suggests that humans process time and space in similar veins. Humans represent time along a spatial continuum, and perception of temporal durations can be altered through manipulations of spatial attention by prismatic adaptation (PA). Here, we investigated whether PA-induced manipulations of spatial attention can also influence more conceptual aspects of time, such as humans' ability to travel mentally back and forward in time (mental time travel, MTT). Before and after leftward- and rightward-PA, participants projected themselves in the past, present or future time (i.e., self-projection), and, for each condition, determined whether a series of events were located in the past or the future with respect to that specific self-location in time (i.e., self-reference). The results demonstrated that leftward and rightward shifts of spatial attention facilitated recognition of past and future events, respectively. These findings suggest that spatial attention affects the temporal processing of the human self. Copyright © 2016 Elsevier B.V. All rights reserved.

Human Factor Studies on a Mars Analogue During Crew 100b International Lunar Exploration Working Group EuroMoonMars Crew: Proposed New Approaches for Future Human Space and Interplanetary Missions.

PubMed

Rai, Balwant; Kaur, Jasdeep

2012-11-01

Knowing the risks, costs, and complexities associated with human missions to Mars, analogue research can be a great (low-risk) tool for exploring the challenges associated with the preparation for living, operating, and undertaking research in interplanetary missions. Short-duration analogue studies, such as those being accomplished at the Mars Desert Research Station (MDRS), offer the chance to study mission operations and human factors in a simulated environment, and therefore contribute to exploration of the Moon and Mars in planned future missions. This article is based upon previously published articles, abstracts, and presentations by a series of independent authors, human factor studies performed on mars analogue station by Crew 100B. The MDRS Crew 100B performed studies over 15 days providing a unique insight into human factor issues in simulated short-duration Mars mission. In this study, 15 human factors were evaluated and analyzed by subjective and objective means, and from the summary of results it was concluded that optimum health of an individual and the crew as a whole is a necessity in order to encourage and maintain high performance and the satisfaction of project goals.

Human Factor Studies on a Mars Analogue During Crew 100b International Lunar Exploration Working Group EuroMoonMars Crew: Proposed New Approaches for Future Human Space and Interplanetary Missions

PubMed Central

Rai, Balwant; Kaur, Jasdeep

2012-01-01

Knowing the risks, costs, and complexities associated with human missions to Mars, analogue research can be a great (low-risk) tool for exploring the challenges associated with the preparation for living, operating, and undertaking research in interplanetary missions. Short-duration analogue studies, such as those being accomplished at the Mars Desert Research Station (MDRS), offer the chance to study mission operations and human factors in a simulated environment, and therefore contribute to exploration of the Moon and Mars in planned future missions. This article is based upon previously published articles, abstracts, and presentations by a series of independent authors, human factor studies performed on mars analogue station by Crew 100B. The MDRS Crew 100B performed studies over 15 days providing a unique insight into human factor issues in simulated short-duration Mars mission. In this study, 15 human factors were evaluated and analyzed by subjective and objective means, and from the summary of results it was concluded that optimum health of an individual and the crew as a whole is a necessity in order to encourage and maintain high performance and the satisfaction of project goals. PMID:23181225

Human Research Program Human Health Countermeasures Element Nutrition Risk Standing Review Panel

NASA Technical Reports Server (NTRS)

Bistrian, Bruce

2009-01-01

The Nutrition Risk Standing Review Panel (SRP) reviewed and discussed the specific gaps and tasks for the Human Health Countermeasures (HHC) Element related to nutrition identified in the Human Research Program (HRP) Integrated Research Plan. There was general consensus that the described gaps and proposed tasks were critical to future NASA mission success. The SRP acknowledged the high scientific quality of the work currently being undertaken by the Nutritional Biochemistry group under the direction of Dr. Scott Smith. In review of the entire HRP, four new gaps were identified that complement the Element's existing research activities. Given the limitations of ground-based analogs for many of the unique physiological and metabolic alterations in space, future studies are needed to quantify nutritional factors that change during actual space flight. In addition, future tasks should seek to better evaluate the time course of physiological and metabolic alterations during flight to better predict alterations during longer duration missions. Finally, given the recent data suggesting a potential role for increased inflammatory responses during space flight, the role of inflammation needs to be explored in detail, including the development of potential countermeasures and new ground based analogs, if this possibility is confirmed.

Research Objectives for Human Missions in the Proving Ground of Cis-Lunar Space

NASA Technical Reports Server (NTRS)

Niles, P. B.; Eppler, D. B.; Kennedy, K. J.; Lewis, R.; Spann, J. F.; Sullivan, T. A.

2016-01-01

Beginning in as early as 2023, crewed missions beyond low Earth orbit will begin enabled by the new capabilities of the SLS and Orion vehicles. This will initiate the "Proving Ground" phase of human exploration with Mars as an ultimate destination. The primary goal of the Proving Ground is to demonstrate the capability of suitably long duration spaceflight without need of continuous support from Earth, i.e. become Earth Independent. A major component of the Proving Ground phase is to conduct research activities aimed at accomplishing major objectives selected from a wide variety of disciplines including but not limited to: Astronomy, Heliophysics, Fundamental Physics, Planetary Science, Earth Science, Human Systems, Fundamental Space Biology, Microgravity, and In A major component of the Proving Ground phase is to conduct research activities aimed at accomplishing major objectives selected from a wide variety of disciplines including but not limited to: Astronomy, Heliophysics, Fundamental Physics, Planetary Science, Earth Science, Human Systems, Fundamental Space Biology, Microgravity, and In Situ Resource Utilization. Mapping and prioritizing the most important objectives from these disciplines will provide a strong foundation for establishing the architecture to be utilized in the Proving Ground.

Space Structure Development

NASA Technical Reports Server (NTRS)

Smith, Thomas

2015-01-01

The duration of my Summer 2015 Internship Tour at NASA's Johnson Space Center was spent working in the Structural Engineering Division's Structures Branch. One of the two main roles of the Structures Branch, ES2, is to ensure the structural integrity of spacecraft vehicles and the structural subsystems needed to support those vehicles. The other main objective of this branch is to develop the lightweight structures that are necessary to take humans beyond Low-Earth Orbit. Within ES2, my four projects involved inflatable space structure air bladder material testing; thermal and impact material testing for spacecraft windows; structural analysis on a joint used in the Boeing CST-100 airbag system; and an additive manufacturing design project.

Habitability Assessment of International Space Station

NASA Technical Reports Server (NTRS)

Thaxton, Sherry

2015-01-01

The purpose of this study is to assess habitability during the International Space Station 1-year mission, and subsequent 6-month missions, in order to better prepare for future long-duration spaceflights to destinations such as Near Earth Asteroid (NEA) and Mars, which will require crewmembers to live and work in a confined spacecraft environment for over a year. Data collected using Space Habitability Observation Reporting Tool (iSHORT), crew-collected videos, questionnaires, and PI conferences will help characterize the current state of habitability for the ISS. These naturalistic techniques provide crewmembers with the opportunity to self-report habitability and human factors observations in near real-time, which is not systematically done during ISS missions at present.

National Aeronautics and Space Administration (NASA) Environmental Control and Life Support (ECLS) Integrated Roadmap Development

NASA Technical Reports Server (NTRS)

Metcalf, Jordan; Peterson, Laurie; Carrasquillo, Robyn; Bagdigian, Robert

2012-01-01

Although NASA is currently considering a number of future human space exploration mission concepts, detailed mission requirements and vehicle architectures remain mostly undefined, making technology investment strategies difficult to develop and sustain without a top-level roadmap to serve as a guide. This paper documents the process and results of an effort to define a roadmap for Environmental Control and Life Support Systems (ECLSS) capabilities required to enhance the long-term operation of the International Space Station (ISS) as well as enable beyond-Low Earth Orbit (LEO) human exploration missions. Three generic mission types were defined to serve as a basis for developing a prioritized list of needed capabilities and technologies. Those are 1) a short duration micro-gravity mission; 2) a long duration microgravity mission; and 3) a long duration partial gravity (surface) exploration mission. To organize the effort, a functional decomposition of ECLSS was completed starting with the three primary functions: atmosphere, water, and solid waste management. Each was further decomposed into sub-functions to the point that current state-of-the-art (SOA) technologies could be tied to the sub-function. Each technology was then assessed by NASA subject matter experts as to its ability to meet the functional needs of each of the three mission types. When SOA capabilities were deemed to fall short of meeting the needs of one or more mission types, those gaps were prioritized in terms of whether or not the corresponding capabilities enable or enhance each of the mission types. The result was a list of enabling and enhancing capability needs that can be used to guide future ECLSS development, as well as a list of existing hardware that is ready to go for exploration-class missions. A strategy to fulfill those needs over time was then developed in the form of a roadmap. Through execution of this roadmap, the hardware and technologies intended to meet exploration needs will, in many cases, directly benefit the ISS operational capability, benefit the Multi-Purpose Crew Vehicle (MPCV), and guide long-term technology investments for longer duration missions.

National Aeronautics and Space Administration (NASA) Environmental Control and Life Support (ECLS) Integrated Roadmap Development

NASA Technical Reports Server (NTRS)

Metcalf, Jordan; Peterson, Laurie; Carrasquillo, Robyn; Bagdigian, Robert

2011-01-01

At present, NASA has considered a number of future human space exploration mission concepts . Yet, detailed mission requirements and vehicle architectures remain mostly undefined, making technology investment strategies difficult to develop and sustain without a top-level roadmap to serve as a guide. This paper documents a roadmap for development of Environmental Control and Life Support Systems (ECLSS) capabilities required to enhance the long-term operation of the International Space Station (ISS) as well as enable beyond-Low Earth Orbit (LEO) human exploration missions. Three generic mission types were defined to serve as a basis for developing a prioritized list of needed capabilities and technologies. Those are 1) a short duration micro gravity mission; 2) a long duration transit microgravity mission; and 3) a long duration surface exploration mission. To organize the effort, ECLSS was categorized into three major functional groups (atmosphere, water, and solid waste management) with each broken down into sub-functions. The ability of existing state-of-the-art (SOA) technologies to meet the functional needs of each of the three mission types was then assessed by NASA subject matter experts. When SOA capabilities were deemed to fall short of meeting the needs of one or more mission types, those gaps were prioritized in terms of whether or not the corresponding capabilities enable or enhance each of the mission types. The result was a list of enabling and enhancing capabilities needs that can be used to guide future ECLSS development, as well as a list of existing hardware that is ready to go for exploration-class missions. A strategy to fulfill those needs over time was then developed in the form of a roadmap. Through execution of this roadmap, the hardware and technologies intended to meet exploration needs will, in many cases, directly benefit the ISS operational capability, benefit the Multi-Purpose Crew Vehicle (MPCV), and guide long-term technology investments for longer duration missions The final product of this paper is an agreed-to ECLSS roadmap detailing ground and flight testing to support the three mission scenarios previously mentioned. This information will also be used to develop the integrated NASA budget submit in January 2012.

Humans in Space: Summarizing the Medico-Biological Results of the Space Shuttle Program

NASA Technical Reports Server (NTRS)

Risin, Diana; Stepaniak, P. C.; Grounds, D. J.

2011-01-01

As we celebrate the 50th anniversary of Gagarin's flight that opened the era of Humans in Space we also commemorate the 30th anniversary of the Space Shuttle Program (SSP) which was triumphantly completed by the flight of STS-135 on July 21, 2011. These were great milestones in the history of Human Space Exploration. Many important questions regarding the ability of humans to adapt and function in space were answered for the past 50 years and many lessons have been learned. Significant contribution to answering these questions was made by the SSP. To ensure the availability of the Shuttle Program experiences to the international space community NASA has made a decision to summarize the medico-biological results of the SSP in a fundamental edition that is scheduled to be completed by the end of 2011 beginning 2012. The goal of this edition is to define the normal responses of the major physiological systems to short-duration space flights and provide a comprehensive source of information for planning, ensuring successful operational activities and for management of potential medical problems that might arise during future long-term space missions. The book includes the following sections: 1. History of Shuttle Biomedical Research and Operations; 2. Medical Operations Overview Systems, Monitoring, and Care; 3. Biomedical Research Overview; 4. System-specific Adaptations/Responses, Issues, and Countermeasures; 5. Multisystem Issues and Countermeasures. In addition, selected operational documents will be presented in the appendices. The chapters are written by well-recognized experts in appropriate fields, peer reviewed, and edited by physicians and scientists with extensive expertise in space medical operations and space-related biomedical research. As Space Exploration continues the major question whether humans are capable of adapting to long term presence and adequate functioning in space habitats remains to be answered We expect that the comprehensive review of the medico-biological results of the SSP along with the data collected during the missions on the space stations (Mir and ISS) provides a good starting point in seeking the answer to this question.

Medical System Concept of Operations for Mars Exploration Missions

NASA Technical Reports Server (NTRS)

Urbina, Michelle; Rubin, D.; Hailey, M.; Reyes, D.; Antonsen, Eric

2017-01-01

Future exploration missions will be the first time humanity travels beyond Low Earth Orbit (LEO) since the Apollo program, taking us to cis-lunar space, interplanetary space, and Mars. These long-duration missions will cover vast distances, severely constraining opportunities for emergency evacuation to Earth and cargo resupply opportunities. Communication delays and blackouts between the crew and Mission Control will eliminate reliable, real-time telemedicine consultations. As a result, compared to current LEO operations onboard the International Space Station, exploration mission medical care requires an integrated medical system that provides additional in-situ capabilities and a significant increase in crew autonomy. The Medical System Concept of Operations for Mars Exploration Missions illustrates how a future NASA Mars program could ensure appropriate medical care for the crew of this highly autonomous mission. This Concept of Operations document, when complete, will document all mission phases through a series of mission use case scenarios that illustrate required medical capabilities, enabling the NASA Human Research Program (HRP) Exploration Medical Capability (ExMC) Element to plan, design, and prototype an integrated medical system to support human exploration to Mars.

Evidence Report: Risk of Performance Errors Due to Training Deficiencies

NASA Technical Reports Server (NTRS)

Barshi, Immanuel

2012-01-01

The Risk of Performance Errors Due to Training Deficiencies is identified by the National Aeronautics and Space Administration (NASA) Human Research Program (HRP) as a recognized risk to human health and performance in space. The HRP Program Requirements Document (PRD) defines these risks. This Evidence Report provides a summary of the evidence that has been used to identify and characterize this risk. Given that training content, timing, intervals, and delivery methods must support crew task performance, and given that training paradigms will be different for long-duration missions with increased crew autonomy, there is a risk that operators will lack the skills or knowledge necessary to complete critical tasks, resulting in flight and ground crew errors and inefficiencies, failed mission and program objectives, and an increase in crew injuries.

Circadian rhythms, sleep, and performance in space.

PubMed

Mallis, M M; DeRoshia, C W

2005-06-01

Maintaining optimal alertness and neurobehavioral functioning during space operations is critical to enable the National Aeronautics and Space Administration's (NASA's) vision "to extend humanity's reach to the Moon, Mars and beyond" to become a reality. Field data have demonstrated that sleep times and performance of crewmembers can be compromised by extended duty days, irregular work schedules, high workload, and varying environmental factors. This paper documents evidence of significant sleep loss and disruption of circadian rhythms in astronauts and associated performance decrements during several space missions, which demonstrates the need to develop effective countermeasures. Both sleep and circadian disruptions have been identified in the Behavioral Health and Performance (BH&P) area and the Advanced Human Support Technology (AHST) area of NASA's Bioastronautics Critical Path Roadmap. Such disruptions could have serious consequences on the effectiveness, health, and safety of astronaut crews, thus reducing the safety margin and increasing the chances of an accident or incident. These decrements oftentimes can be difficult to detect and counter effectively in restrictive operational environments. NASA is focusing research on the development of optimal sleep/wake schedules and countermeasure timing and application to help mitigate the cumulative effects of sleep and circadian disruption and enhance operational performance. Investing research in humans is one of NASA's building blocks that will allow for both short- and long-duration space missions and help NASA in developing approaches to manage and overcome the human limitations of space travel. In addition to reviewing the current state of knowledge concerning sleep and circadian disruptions during space operations, this paper provides an overview of NASA's broad research goals. Also, NASA-funded research, designed to evaluate the relationships between sleep quality, circadian rhythm stability, and performance proficiency in both ground-based simulations and space mission studies, as described in the 2003 NASA Task Book, will be reviewed.

Circadian rhythms, sleep, and performance in space

NASA Technical Reports Server (NTRS)

Mallis, M. M.; DeRoshia, C. W.

2005-01-01

Maintaining optimal alertness and neurobehavioral functioning during space operations is critical to enable the National Aeronautics and Space Administration's (NASA's) vision "to extend humanity's reach to the Moon, Mars and beyond" to become a reality. Field data have demonstrated that sleep times and performance of crewmembers can be compromised by extended duty days, irregular work schedules, high workload, and varying environmental factors. This paper documents evidence of significant sleep loss and disruption of circadian rhythms in astronauts and associated performance decrements during several space missions, which demonstrates the need to develop effective countermeasures. Both sleep and circadian disruptions have been identified in the Behavioral Health and Performance (BH&P) area and the Advanced Human Support Technology (AHST) area of NASA's Bioastronautics Critical Path Roadmap. Such disruptions could have serious consequences on the effectiveness, health, and safety of astronaut crews, thus reducing the safety margin and increasing the chances of an accident or incident. These decrements oftentimes can be difficult to detect and counter effectively in restrictive operational environments. NASA is focusing research on the development of optimal sleep/wake schedules and countermeasure timing and application to help mitigate the cumulative effects of sleep and circadian disruption and enhance operational performance. Investing research in humans is one of NASA's building blocks that will allow for both short- and long-duration space missions and help NASA in developing approaches to manage and overcome the human limitations of space travel. In addition to reviewing the current state of knowledge concerning sleep and circadian disruptions during space operations, this paper provides an overview of NASA's broad research goals. Also, NASA-funded research, designed to evaluate the relationships between sleep quality, circadian rhythm stability, and performance proficiency in both ground-based simulations and space mission studies, as described in the 2003 NASA Task Book, will be reviewed.

Changes in Body Inertia During Bed Rest Studies

NASA Technical Reports Server (NTRS)

Todd, Beth A.

1999-01-01

Development of effective exercise countermeasures is crucial for long duration human space flight. To analyze the mechanical effects of a particular exercise on the musculoskeletal system, the inertial properties of segments of the body must be quantified. Since bone mineral density loss is related to the lack of mechanical stress and strain on the skeletal system, physical analysis can be very useful for countermeasure evaluation.

A High Power Solar Electric Propulsion - Chemical Mission for Human Exploration of Mars

NASA Technical Reports Server (NTRS)

Burke, Laura M.; Martini, Michael C.; Oleson, Steven R.

2014-01-01

Recently Solar Electric Propulsion (SEP) as a main propulsion system has been investigated as an option to support manned space missions to near-Earth destinations for the NASA Gateway spacecraft. High efficiency SEP systems are able to reduce the amount of propellant long duration chemical missions require, ultimately reducing the required mass delivered to Low Earth Orbit (LEO) by a launch vehicle. However, for long duration interplanetary Mars missions, using SEP as the sole propulsion source alone may not be feasible due to the long trip times to reach and insert into the destination orbit. By combining an SEP propulsion system with a chemical propulsion system the mission is able to utilize the high-efficiency SEP for sustained vehicle acceleration and deceleration in heliocentric space and the chemical system for orbit insertion maneuvers and trans-earth injection, eliminating the need for long duration spirals. By capturing chemically instead of with low-thrust SEP, Mars stay time increases by nearly 200 days. Additionally, the size the of chemical propulsion system can be significantly reduced from that of a standard Mars mission because the SEP system greatly decreases the Mars arrival and departure hyperbolic excess velocities (V(sub infinity)).

Human Immune Function and Microbial Pathogenesis in Human Spaceflight

NASA Technical Reports Server (NTRS)

Pierson, Duane J.; Ott, M.

2006-01-01

This oral presentation was requested by Conference conveners. The requested subject is microbial risk assessment considering changes in the human immune system during flight and microbial diversity of environmental samples aboard the International Space Station (ISS). The presentation will begin with an introduction discussing the goals and limitations of microbial risk assessment during flight. The main portion of the presentation will include changes in the immune system that have been published, historical data from microbial analyses, and initial modeling of the environmental flora aboard ISS. The presentation will conclude with future goals and techniques to enhance our ability to perform microbial risk assessment on long duration missions.

Summary: achievements, critical issues, and thoughts on the future.

PubMed

Held, Kathryn D

2012-11-01

The number of individuals exposed to particle radiations in cancer treatment worldwide is increasing rapidly, and space agencies are developing plans for long duration, deep space missions in which humans could be exposed to significant levels of radiation from charged particles. Hence, the NCRP 47 th Annual Meeting on "Scientific and Policy Challenges of Particle Radiations in Medical Therapy and Space Missions" was a timely opportunity to showcase the current scientific knowledge regarding charged particles, enhance cross-fertilization between the oncology and space scientific communities, and identify common needs and challenges to both communities as well as ways to address those challenges. This issue of Health Physics contains papers from talks presented at that meeting and highlights provocative questions and the ample opportunities for synergism between space and particle-therapy research to further understanding of the biological impacts of particle radiations.

The Growing Legacy of Spinoffs from the International Space Station and Prospects for Future Benefits

NASA Astrophysics Data System (ADS)

Comstock, D.; Lockney, D.

A multinational effort involving NASA employees and contractors across the United States and space agencies in 15 countries, the International Space Station (ISS) is humanity's home in space and has captured the world's imagination since its first component launched into orbit in 1998. While the ISS provides invaluable information about living in space--essential for future long-duration missions and colonies on the Moon and Mars--everything from the station's construction to biological experiments conducted onboard have led to spinoffs that are improving life on Earth. As the ISS nears completion, this paper highlights ISS-influenced technologies that are advancing fitness and medicine, purifying air and water, enhancing safety, and improving daily life in many other ways. This paper also examines several other promising future benefits derived from the ISS.

Safe Haven Configurations for Deep Space Transit Habitats

NASA Technical Reports Server (NTRS)

Smitherman, David; Polsgrove, Tara; Rowe, Justin; Simon, Matthew

2017-01-01

Throughout the human space flight program there have been instances where smoke, fire, and pressure loss have occurred onboard space vehicles, putting crews at risk for loss of mission and loss of life. In every instance the mission has been in Low-Earth-Orbit (LEO) with access to multiple volumes that could be used to quickly seal off the damaged module or escape vehicles for a quick return to Earth. For long duration space missions beyond LEO, including Mars transit missions of about 1000 days, the mass penalty for multiple volumes has been a concern as has operating in an environment where a quick return will not be possible. In 2016 a study was done to investigate a variety of dual pressure vessel configurations for habitats that could protect the crew from these hazards. It was found that for a modest increase in total mass it should be possible to provide significant protection for the crew. Several configurations were developed that either had a small safe haven to provide 30-days to recover, or a full duration safe haven using two equal size pressure vessel volumes. The 30-day safe haven was found to be the simplest, yielding the least total mass impact but still with some risk if recovery is not possible during that timeframe. The full duration safe haven was the most massive option but provided the most robust solution. This paper provides information on the various layouts considered in the study and provides a discussion of the findings for implementing a safe haven in future habitat designs.

AFTER 188 DAYS IN SPACE, SHANNON LUCID TALKS TO PRESIDENT CLINTON

NASA Technical Reports Server (NTRS)

1996-01-01

With her historic six-month stay aboard the Russian Space Station Mir completed, U.S. astronaut Shannon W. Lucid accepts a congratulatory phone call from President Bill Clinton. Lucid's on-orbit journey began March 22, when she embarked to Mir with the crew of Mission STS-76 aboard the Space Shuttle Atlantis. By the time she returned to Earth earlier today, again aboard Atlantis but with the crew of Mission STS-79, she had logged 188 days in space: a U.S. record for long-duration human spaceflight as well as the longest stay in space by a woman. Lucid and her five fellow STS-79 crew members are spending the night here in the Operations and Checkout Building before returning to Johnson Space Center in Houston. Atlantis touched down on Runway 15 of KSC's Shuttle Landing Facility at 8:13:15 a.m. EDT.

Impact of the Columbia Supercomputer on NASA Space and Exploration Mission

NASA Technical Reports Server (NTRS)

Biswas, Rupak; Kwak, Dochan; Kiris, Cetin; Lawrence, Scott

2006-01-01

NASA's 10,240-processor Columbia supercomputer gained worldwide recognition in 2004 for increasing the space agency's computing capability ten-fold, and enabling U.S. scientists and engineers to perform significant, breakthrough simulations. Columbia has amply demonstrated its capability to accelerate NASA's key missions, including space operations, exploration systems, science, and aeronautics. Columbia is part of an integrated high-end computing (HEC) environment comprised of massive storage and archive systems, high-speed networking, high-fidelity modeling and simulation tools, application performance optimization, and advanced data analysis and visualization. In this paper, we illustrate the impact Columbia is having on NASA's numerous space and exploration applications, such as the development of the Crew Exploration and Launch Vehicles (CEV/CLV), effects of long-duration human presence in space, and damage assessment and repair recommendations for remaining shuttle flights. We conclude by discussing HEC challenges that must be overcome to solve space-related science problems in the future.

Potential Applications of Modularity to Enable a Deep Space Habitation Capability for Future Human Exploration Beyond Low-Earth Orbit

NASA Technical Reports Server (NTRS)

Simon, Matthew A.; Toups, Larry; Smitherman, David

2012-01-01

Evaluating preliminary concepts of a Deep Space Habitat (DSH) enabling long duration crewed exploration of asteroids, the Moon, and Mars is a technically challenging problem. Sufficient habitat volumes and equipment, necessary to ensure crew health and functionality, increase propellant requirements and decrease launch flexibility to deliver multiple elements on a single launch vehicle; both of which increase overall mission cost. Applying modularity in the design of the habitat structures and subsystems can alleviate these difficulties by spreading the build-up of the overall habitation capability across several smaller parts. This allows for a more flexible habitation approach that accommodates various crew mission durations and levels of functionality. This paper provides a technical analysis of how various modular habitation approaches can impact the parametric design of a DSH with potential benefits in mass, packaging volume, and architectural flexibility. This includes a description of the desired long duration habitation capability, the definition of a baseline model for comparison, a small trade study to investigate alternatives, and commentary on potentially advantageous configurations to enable different levels of habitability. The approaches investigated include modular pressure vessel strategies, modular subsystems, and modular manufacturing approaches to habitat structure. The paper also comments upon the possibility of an integrated habitation strategy using modular components to create all short and long duration habitation elements required in the current exploration architectures.

Microgravity Manufacturing

NASA Technical Reports Server (NTRS)

Cooper, Ken; Munafo, Paul M. (Technical Monitor)

2002-01-01

Manufacturing capability in outer space remains one of the critical milestones to surpass to allow humans to conduct long-duration manned space exploration. The high cost-to-orbit for leaving the Earth's gravitational field continues to be the limiting factor in carrying sufficient hardware to maintain extended life support in microgravity or on other planets. Additive manufacturing techniques, or 'chipless' fabrication, like RP are being considered as the most promising technologies for achieving in situ or remote processing of hardware components, as well as for the repair of existing hardware. At least three RP technologies are currently being explored for use in microgravity and extraterrestrial fabrication.

@Astro_Wheels Tweetup

NASA Image and Video Library

2011-03-16

A tweetuup participant videotapes with her iPhone and tweets as astronaut Doug Wheelock discusses his experiences while living on the International Space Station during a tweetup at NASA Headquarters in Washington, Wednesday, March 16, 2011. Wheelock, who has accumulated a total of 178 days in space, assumed command of the International Space Station and the Expedition 25 crew. During Expedition 25, there were more than 120 microgravity experiments in human research; biology and biotechnology; physical and materials sciences; technology development; and Earth and space sciences. Wheelock also responded to an emergency shutdown of half of the station's external cooling system and supported three unplanned spacewalks to replace the faulty pump module that caused the shutdown. His efforts restored the station's critical cooling system to full function. The mission duration was 163 days. Photo Credit: (NASA/Paul E. Alers)

Face to Face Communications in Space

NASA Technical Reports Server (NTRS)

Cohen, Malcolm M.; Davon, Bonnie P. (Technical Monitor)

1999-01-01

It has been reported that human face-to-face communications in space are compromised by facial edema, variations in the orientations of speakers and listeners, and background noises that are encountered in the shuttle and in space stations. To date, nearly all reports have been anecdotal or subjective, in the form of post-flight interviews or questionnaires; objective and quantitative data are generally lacking. Although it is acknowledged that efficient face-to-face communications are essential for astronauts to work safely and effectively, specific ways in which the space environment interferes with non-linguistic communication cues are poorly documented. Because we have only a partial understanding of how non-linguistic communication cues may change with mission duration, it is critically important to obtain objective data, and to evaluate these cues under well-controlled experimental conditions.

Human Factor Investigation of Waste Processing System During the HI-SEAS 4 Month Mars Analog Mission in Support of NASA's Logistic Reduction and Repurposing Project: Trash to Gas

NASA Technical Reports Server (NTRS)

Caraccio, Anne; Hintze, Paul; Miles, John D.

2014-01-01

NASAs Logistics Reduction and Repurposing (LRR) project is a collaborative effort in which NASA is tasked with reducing total logistical mass through reduction, reuse and recycling of various wastes and components of long duration space missions and habitats. Trash to Gas (TtG) is a sub task to LRR with efforts focused on development of a technology that converts wastes generated during long duration space missions into high-value products such as methane, water for life support, raw material production feedstocks, and other energy sources. The reuse of discarded materials is a critical component to reducing overall mission mass. The 120 day Hawaii Space Exploration and Analog Simulation provides a unique opportunity to answer questions regarding crew interface and system analysis for designing and developing future flight-like versions of a TtG system. This paper will discuss the human factors that would affect the design of a TtG or other waste processing systems. An overview of the habitat, utility usage, and waste storage and generation is given. Crew time spent preparing trash for TtG processing was recorded. Gas concentrations were measured near the waste storage locations and at other locations in the habitat. In parallel with the analog mission, experimental processing of waste materials in a TtG reactor was performed in order to evaluate performance with realistic waste materials.

Human Factor Investigation of Waste Processing System During the HI-SEAS 4-month Mars Analog Mission in Support of NASA's Logistic Reduction and Repurposing Project: Trash to Gas

NASA Technical Reports Server (NTRS)

Caraccio, Anne; Hintze, Paul E.; Miles, John D.

2014-01-01

NASA's Logistics Reduction and Repurposing (LRR) project is a collaborative effort in which NASA is tasked with reducing total logistical mass through reduction, reuse and recycling of various wastes and components of long duration space missions and habitats. Trash to Gas (TtG) is a sub task to LRR with efforts focused on development of a technology that converts wastes generated during long duration space missions into high-value products such as methane, water for life support, raw material production feedstocks, and other energy sources. The reuse of discarded materials is a critical component to reducing overall mission mass. The 120 day Hawaii Space Exploration and Analog Simulation provides a unique opportunity to answer questions regarding crew interface and system analysis for designing and developing future flight-like versions of a TtG system. This paper will discuss the human factors that would affect the design of a TtG or other waste processing systems. An overview of the habitat, utility usage, and waste storage and generation is given. Crew time spent preparing trash for TtG processing was recorded. Gas concentrations were measured near the waste storage locations and at other locations in the habitat. In parallel with the analog mission, experimental processing of waste materials in a TtG reactor was performed in order to evaluate performance with realistic waste materials.

The Astronaut-Athlete: Optimizing Human Performance in Space.

PubMed

Hackney, Kyle J; Scott, Jessica M; Hanson, Andrea M; English, Kirk L; Downs, Meghan E; Ploutz-Snyder, Lori L

2015-12-01

It is well known that long-duration spaceflight results in deconditioning of neuromuscular and cardiovascular systems, leading to a decline in physical fitness. On reloading in gravitational environments, reduced fitness (e.g., aerobic capacity, muscular strength, and endurance) could impair human performance, mission success, and crew safety. The level of fitness necessary for the performance of routine and off-nominal terrestrial mission tasks remains an unanswered and pressing question for scientists and flight physicians. To mitigate fitness loss during spaceflight, resistance and aerobic exercise are the most effective countermeasure available to astronauts. Currently, 2.5 h·d, 6-7 d·wk is allotted in crew schedules for exercise to be performed on highly specialized hardware on the International Space Station (ISS). Exercise hardware provides up to 273 kg of loading capability for resistance exercise, treadmill speeds between 0.44 and 5.5 m·s, and cycle workloads from 0 and 350 W. Compared to ISS missions, future missions beyond low earth orbit will likely be accomplished with less vehicle volume and power allocated for exercise hardware. Concomitant factors, such as diet and age, will also affect the physiologic responses to exercise training (e.g., anabolic resistance) in the space environment. Research into the potential optimization of exercise countermeasures through use of dietary supplementation, and pharmaceuticals may assist in reducing physiological deconditioning during long-duration spaceflight and have the potential to enhance performance of occupationally related astronaut tasks (e.g., extravehicular activity, habitat construction, equipment repairs, planetary exploration, and emergency response).

Active Control of NITINOL-Reinforced Structural Composites

DTIC Science & Technology

1992-10-12

useful in many critical structures that are intended to operate autonomously for long durations in isolated environments such as defense vehicles , space...durations in isolated environment such as defense vehicles , space structures and satellites. ACKNOWLEDGEMENTS This work is funded by a grant from the US Army...are intended to operate autonomously for long durations in isolated environment such as defense vehicles , space structures and satellites. REFERENCES

Cryogenic Propellant Storage and Transfer (CPST) Technology Maturation: Establishing a Foundation for a Technology Demonstration Mission (TDM)

NASA Technical Reports Server (NTRS)

Doherty, Michael P.; Meyer, Michael L.; Motil, Susan M.; Ginty, Carol A.

2014-01-01

As part of U.S. National Space Policy, NASA is seeking an innovative path for human space exploration, which strengthens the capability to extend human and robotic presence throughout the solar system. NASA is laying the groundwork to enable humans to safely reach multiple potential destinations, including asteroids, Lagrange points, the Moon and Mars. In support of this, NASA is embarking on the Technology Demonstration Mission Cryogenic Propellant Storage and Transfer (TDM CPST) Project to test and validate key cryogenic capabilities and technologies required for future exploration elements, opening up the architecture for large cryogenic propulsion stages (CPS) and propellant depots. The TDM CPST project will provide an on-orbit demonstration of the capability to store, transfer, and measure cryogenic propellants for a duration which is relevant to enable long term human space exploration missions beyond low Earth orbit (LEO). Recognizing that key cryogenic fluid management technologies anticipated for on-orbit (flight) demonstration needed to be matured to a readiness level appropriate for infusion into the design of the flight demonstration, the NASA Headquarters Space Technology Mission Directorate authorized funding for a one-year (FY12) ground based technology maturation program. The strategy, proposed by the CPST Project Manager, focused on maturation through modeling, studies, and ground tests of the storage and fluid transfer Cryogenic Fluid Management (CFM) technology sub-elements and components that were not already at a Technology Readiness Level (TRL) of 5. A technology maturation plan (TMP) was subsequently approved which described: the CFM technologies selected for maturation, the ground testing approach to be used, quantified success criteria of the technologies, hardware and data deliverables, and a deliverable to provide an assessment of the technology readiness after completion of the test, study or modeling activity. This paper will present the testing, studies, and modeling that occurred in FY12 to mature cryogenic fluid management technologies for propellant storage, transfer, and supply, to examine extensibility to full scale, long duration missions, and to develop and validate analytical models. Finally, the paper will briefly describe an upcoming test to demonstrate Liquid Oxygen (LO2) Zero Boil-Off (ZBO).

Cryogenic Propellant Storage and Transfer (CPST) Technology Maturation: Establishing a Foundation for a Technology Demonstration Mission (TDM)

NASA Technical Reports Server (NTRS)

Doherty, Michael P.; Meyer, Michael L.; Motil, Susan M.; Ginty, Carol A.

2013-01-01

As part of U.S. National Space Policy, NASA is seeking an innovative path for human space exploration, which strengthens the capability to extend human and robotic presence throughout the solar system. NASA is laying the groundwork to enable humans to safely reach multiple potential destinations, including asteroids, Lagrange points, the Moon and Mars. In support of this, NASA is embarking on the Technology Demonstration Mission Cryogenic Propellant Storage and Transfer (TDM CPST) Project to test and validate key cryogenic capabilities and technologies required for future exploration elements, opening up the architecture for large cryogenic propulsion stages (CPS) and propellant depots. The TDM CPST project will provide an on-orbit demonstration of the capability to store, transfer, and measure cryogenic propellants for a duration which is relevant to enable long term human space exploration missions beyond low Earth orbit (LEO). Recognizing that key cryogenic fluid management technologies anticipated for on-orbit (flight) demonstration needed to be matured to a readiness level appropriate for infusion into the design of the flight demonstration, the NASA Headquarters Space Technology Mission Directorate authorized funding for a one-year (FY12) ground based technology maturation program. The strategy, proposed by the CPST Project Manager, focused on maturation through modeling, studies, and ground tests of the storage and fluid transfer Cryogenic Fluid Management (CFM) technology sub-elements and components that were not already at a Technology Readiness Level (TRL) of 5. A technology maturation plan (TMP) was subsequently approved which described: the CFM technologies selected for maturation, the ground testing approach to be used, quantified success criteria of the technologies, hardware and data deliverables, and a deliverable to provide an assessment of the technology readiness after completion of the test, study or modeling activity. This paper will present the testing, studies, and modeling that occurred in FY12 to mature cryogenic fluid management technologies for propellant storage, transfer, and supply, to examine extensibility to full scale, long duration missions, and to develop and validate analytical models. Finally, the paper will briefly describe an upcoming test to demonstrate Liquid Oxygen (LO2) Zero Boil- Off (ZBO).

Exploring the Feasibility of Electrostatic Shielding for Spacecrafts

NASA Technical Reports Server (NTRS)

Tripathi, R. K.; Wilson, J. W.; Youngquist, R. C.

2005-01-01

NASA is moving forward towards the agency's new vision for space exploration in the 21st Century encompassing a broad range of human and robotic missions including missions to Moon, Mars and beyond. Exposure from the hazards of severe space radiation in deep space long duration missions is the show stopper. Langley has developed state-of-the-art radiation protection and shielding technology for space missions. The payload penalty demands a very stringent requirement on the design of the spacecrafts for human deep space missions. The exploration beyond low Earth orbit (LEO) to enable routine access to more interesting regions of space will require protection from the hazards of the accumulated exposures of space radiation, Galactic Cosmic Rays (GCR) and Solar Particle Events (SPE), and minimizing the production of secondary radiation is a great advantage. There is a need to look to new horizons for newer technologies. The present investigation explores the feasibility of using electrostatic shielding in concert with innovative materials shielding and protection technologies. The asymmetries of the radiation shielding problem would be exploited in the electrostatics shielding process. The goal is to repel enough positive charge ions so that they miss the spacecraft without attracting thermal electrons. Conclusions are drawn about the advantages the electrostatic shielding, should it be successful, would bring to the radiation protection design process.

Worms to astronauts: Canadian Space Agency approach to life sciences in support of exploration

NASA Astrophysics Data System (ADS)

Buckley, Nicole; Johnson-Green, Perry; Lefebvre, Luc

As the pace of human exploration of space is accelerated, the need to address the challenges of long-duration human missions becomes imperative. Working with limited resources, we must determine the most effective way to meet this challenge. A great deal of science management centres on "applied" versus "basic" research as the cornerstone of a program. We have chosen to largely ignore such a labeling of science and concentrate on quality, as determined by peer review, as the primary criterion for science selection. Space Life Sciences is a very young science and access to space continues to be difficult. Because we have few opportunities for conducting science, and space life science is very challenging, we are comfortable maintaining a very high bar for selection. In order to ensure adequate depth to our community we have elected to concentrate our efforts. Working in concert with members of the community, we have identified specific areas of focus that are chosen by their importance in space, but also according to Canada's strength in the terrestrial counterpart of the research. It is hoped that through a balanced but highly competitive program with the emphasis on quality, Canadian scientists can contribute to making space a safer, more welcoming place for our astronauts.

14 CFR 21.313 - Duration.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Duration. 21.313 Section 21.313 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Approval of Materials, Parts, Processes, and Appliances § 21.313 Duration...

Bringing Gravity to Space

NASA Technical Reports Server (NTRS)

Norsk, P.; Shelhamer, M.

2016-01-01

This panel will present NASA's plans for ongoing and future research to define the requirements for Artificial Gravity (AG) as a countermeasure against the negative health effects of long-duration weightlessness. AG could mitigate the gravity-sensitive effects of spaceflight across a host of physiological systems. Bringing gravity to space could mitigate the sensorimotor and neuro-vestibular disturbances induced by G-transitions upon reaching a planetary body, and the cardiovascular deconditioning and musculoskeletal weakness induced by weightlessness. Of particular interest for AG during deep-space missions is mitigation of the Visual Impairment Intracranial Pressure (VIIP) syndrome that the majority of astronauts exhibit in space to varying degrees, and which presumably is associated with weightlessness-induced fluid shift from lower to upper body segments. AG could be very effective for reversing the fluid shift and thus help prevent VIIP. The first presentation by Dr. Charles will summarize some of the ground-based and (very little) space-based research that has been conducted on AG by the various space programs. Dr. Paloski will address the use of AG during deep-space exploration-class missions and describe the different AG scenarios such as intra-vehicular, part-of-vehicle, or whole-vehicle centrifugations. Dr. Clement will discuss currently planned NASA research as well as how to coordinate future activities among NASA's international partners. Dr. Barr will describe some possible future plans for using space- and ground-based partial-G analogs to define the relationship between physiological responses and G levels between 0 and 1. Finally, Dr. Stenger will summarize how the human cardiovascular system could benefit from intermittent short-radius centrifugations during long-duration missions.

An Earthling to an Astronaut: Medical Challenges

NASA Technical Reports Server (NTRS)

Davis, Jeffrey R.

2011-01-01

Humans can travel safely into space in low Earth orbit (LEO) or to near-Earth objects if several medical, physiological, environmental, and human factors issues risks are mitigated. Research must be performed in order to set standards in these four areas, and current NASA standards are contained in the Space Flight Human System Standards volumes 1 and 2, and crew medical certification standards. These three sets of standards drive all of the clinical, biomedical research and environmental technology development for the NASA human space flight program. These standards also drive the identification of specific risks to crew health and safety, and we currently manage 65 human system risks within the human space flight program. Each risk has a specific program of research, technology development, and development of operational procedures to mitigate the risks. Some of the more important risks tat will be discussed in this talk include exposure to radiation, behavioral health due to confinement in a closed cabin, physiological changes such as loss of bone, muscle and exercise capability, reduction in immune system capability, environmental threats of maintaining an adequate atmosphere and water for drinking, avoidance of toxic or infectious material, protection of hearing, and human factors issues of equipment and task design. A nutritious and varied food supply must also be provided. All of these risks will be discussed and current strategies for mitigating these risks for long-duration human space flight. In mitigating these 65 human system risks, novel approaches to problem solving must be employed to find the most appropriate research and technology based applications. Some risk mitigations are developed internally to NASA while others are found through research grants, technology procurements, and more recently open innovation techniques to seek solutions from the global technical community. Examples and results will be presented from all of these approaches including the more recent use of prizes to stimulate innovation.

Space Radiation Protection, Space Weather, and Exploration

NASA Technical Reports Server (NTRS)

Zapp, Neal; Rutledge, R.; Semones, E. J.; Johnson, A. S.; Guetersloh, S.; Fry, D.; Stoffle, N.; Lee, K.

2008-01-01

Management of crew exposure to radiation is a major concern for manned spaceflight -- and will be even more important for the modern concept of longer-duration exploration. The inherent protection afforded to astronauts by the magnetic field of the Earth in Low Earth Orbit (LEO) makes operations on the space shuttle or space station very different from operations during an exploration mission. In order to experience significant radiation-derived Loss of Mission (LOM) or Loss of Crew (LOC) risk for LEO operations, one is almost driven to dictate extreme duration or to dictate an extreme sequence of solar activity. Outside of the geo-magnetosphere, however, this scenario changes dramatically. Exposures to the same event on the ISS and on the surface of the Moon may differ by multiple orders of magnitude. This change in magnitude, coupled with the logistical constraints present in implementing any practical operational mitigation make situational awareness with regard to space weather a limiting factor for our ability to conduct exploration operations. With these differences in risk to crew, vehicle and mission in mind, we present the status of the efforts currently underway as the required development to enable exploration operations. The changes in the operating environment as crewed operations begin to stretch away from the Earth are changing the way we think about the lines between "research" and "operations". The real, practical work to enable a permanent human presence away from Earth has already begun.

Non-invasive, quantitative, and remote detection of early radiation cataracts for applications in bio-astronautics and bio-informatics

NASA Astrophysics Data System (ADS)

Ansari, Rafat R.; Giblin, Frank J.; King, James F.

2001-02-01

Human exploration of Mars may be a possibility in the next twenty years. Maintaining good vision is an essential aspect of achieving a successful mission. Continuous radiation exposure is a risk factor for radiation-induced cataracts in astronauts. A compact device based on the technique of dynamic light scattering (DLS) is designed for monitoring an astronaut's ocular health during long-duration space travel. Preliminary data on the simulated effects of ionizing radiation exposure to the ocular tissues of non-human animals and results on the sensitivity of DLS over established clinical procedures in investigating cataracts are presented. This capability of early diagnosis, unmatched by any other clinical technique in use today, may enable prompt initiation of preventive/curative therapy. An inter-net web based system integrating photon correlation data and controlling the hardware to monitor cataract development in vivo at a remote site in real time (tele-ophthalmology) is currently being developed. Cataract studies on-board the International Space Station (ISS) will be helpful in designing better protective radiation shields for future space vehicles and space suits. .

Concepts and challenges in cancer risk prediction for the space radiation environment

NASA Astrophysics Data System (ADS)

Barcellos-Hoff, Mary Helen; Blakely, Eleanor A.; Burma, Sandeep; Fornace, Albert J.; Gerson, Stanton; Hlatky, Lynn; Kirsch, David G.; Luderer, Ulrike; Shay, Jerry; Wang, Ya; Weil, Michael M.

2015-07-01

Cancer is an important long-term risk for astronauts exposed to protons and high-energy charged particles during travel and residence on asteroids, the moon, and other planets. NASA's Biomedical Critical Path Roadmap defines the carcinogenic risks of radiation exposure as one of four type I risks. A type I risk represents a demonstrated, serious problem with no countermeasure concepts, and may be a potential "show-stopper" for long duration spaceflight. Estimating the carcinogenic risks for humans who will be exposed to heavy ions during deep space exploration has very large uncertainties at present. There are no human data that address risk from extended exposure to complex radiation fields. The overarching goal in this area to improve risk modeling is to provide biological insight and mechanistic analysis of radiation quality effects on carcinogenesis. Understanding mechanisms will provide routes to modeling and predicting risk and designing countermeasures. This white paper reviews broad issues related to experimental models and concepts in space radiation carcinogenesis as well as the current state of the field to place into context recent findings and concepts derived from the NASA Space Radiation Program.

Habitat Concepts for Deep Space Exploration

NASA Technical Reports Server (NTRS)

Smitherman, David; Griffin, Brand N.

2014-01-01

Future missions under consideration requiring human habitation beyond the International Space Station (ISS) include deep space habitats in the lunar vicinity to support asteroid retrieval missions, human and robotic lunar missions, satellite servicing, and Mars vehicle servicing missions. Habitat designs are also under consideration for missions beyond the Earth-Moon system, including transfers to near-Earth asteroids and Mars orbital destinations. A variety of habitat layouts have been considered, including those derived from the existing ISS designs and those that could be fabricated from the Space Launch System (SLS) propellant tanks. This paper presents a comparison showing several options for asteroid, lunar, and Mars mission habitats using ISS derived and SLS derived modules and identifies some of the advantages and disadvantages inherent in each. Key findings indicate that the larger SLS diameter modules offer built-in compatibility with the launch vehicle, single launch capability without on-orbit assembly, improved radiation protection, lighter structures per unit volume, and sufficient volume to accommodate consumables for long duration missions without resupply. The information provided with the findings includes mass and volume comparison data that should be helpful to future exploration mission planning efforts.

Sleeping on Mars: A Hidden Challenge for Human Space Exploration

NASA Technical Reports Server (NTRS)

Flynn-Evans, Erin

2017-01-01

The purpose of this talk is to provide a general public audience with basic information about what it is like to sleep in space. Dr. Flynn-Evans will begin by highlighting how sleep is different in movies and science fiction compared to real life. She will next cover basic information about sleep and circadian rhythms, including how sleep works on earth. She will explain how people have circadian rhythms of different lengths and how the circadian clock has to be re-set each day. She will also describe how jet-lag works as an example of what happens during circadian misalignment. Dr. Flynn-Evans will also describe how sleep is different in space and will highlight the challenges that astronauts face in low-earth orbit. She will discuss how astronauts have a shorter sleep duration in space relative to on the ground and how their schedules can shift due to operational constraints. She will also describe how these issues affect alertness and performance. She will then discuss how sleep and scheduling may be different on a long-duration mission to Mars. She will discuss the differences in light and day length on earth and mars and illustrate how those differences pose significant challenges to sleep and circadian rhythms.

Human migration to space: Alternative technological approaches for long-term adaptation to extraterrestrial environments and the implications for human evolution

NASA Astrophysics Data System (ADS)

Lockard, Elizabeth Song

As humans embark upon the next phase of Space exploration---establishing human outposts in low-Earth orbit, on the Moon, and on Mars---the scope of human factors must expand beyond the meager requirements for short-term missions to Space to include issues of comfort and well-being necessary for long-term durations. However, to habitate---to dwell in a place---implies more than creature comforts in order to adapt. Human factors research must also include a phenomenological perspective---an understanding of how we experience the places we live in---in order for a community to be robust and to thrive. The first phase of migration will be an especially tenuous one requiring intensive technological intervention. The modes by which those technologies are implemented will have significant bearing on the process of human adaptation: the nature of the mediation can be either one of domination, subordination, avoidance, or integration. Ultimately, adaptation is best ensured if symbiotic processes of negotiation and cooperation between subject and environment are espoused over acts of conquest or acquiescence. The adaptive mechanisms we choose to develop and employ will have wider implications for long-range human evolution. The transformations we will undergo will be influenced by both the initial decision to migrate to Space (technological), as well as the actual conditions of Space (environmental). Migration to extraterrestrial environments will be unequivocally the most profound catalyst for evolution in the history of humankind---not only for the human species itself but also for the new environments we will eventually inhabit. At the same time, we also find ourselves---via a new generation of bio-, nano-, and digital technologies---in the position to consciously and willfully direct our own evolution. Technology has always been transformative, but in the not-so-distant future, we will soon possess the capacity to radically re-invent ourselves in almost any way conceivable. The discourse on human evolution in Space must be situated in the confluence of these two variables.

Principal Investigator-in-a-Box

NASA Technical Reports Server (NTRS)

Young, Laurence R.

1999-01-01

Human performance in orbit is currently limited by several factors beyond the intrinsic awkwardness of motor control in weightlessness. Cognitive functioning can be affected by such factors as cumulative sleep loss, stress and the psychological effects of long-duration small-group isolation. When an astronaut operates a scientific experiment, the performance decrement associated with such factors can lead to lost or poor quality data and even the total loss of a scientific objective, at great cost to the sponsors and to the dismay of the Principal Investigator. In long-duration flights, as anticipated on the International Space Station and on any planetary exploration, the experimental model is further complicated by long delays between training and experiment, and the large number of experiments each crew member must perform. Although no documented studies have been published on the subject, astronauts report that an unusually large number of simple errors are made in space. Whether a result of the effects of microgravity, accumulated fatigue, stress or other factors, this pattern of increased error supports the need for a computerized decision-making aid for astronauts performing experiments. Artificial intelligence and expert systems might serve as powerful tools for assisting experiments in space. Those conducting space experiments typically need assistance exactly when the planned checklist does not apply. Expert systems, which use bits of human knowledge and human methods to respond appropriately to unusual situations, have a flexibility that is highly desirable in circumstances where an invariably predictable course of action/response does not exist. Frequently the human expert on the ground is unavailable, lacking the latest information, or not consulted by the astronaut conducting the experiment. In response to these issues, we have developed "Principal Investigator-in-a-Box," or [PI], to capture the reasoning process of the real expert, the Principal Investigator, and combine that with real-time data available in space in order to advise the astronaut about how to proceed in real time. [PI] advises the astronaut during the progress of an experiment in much the same way a real Principal Investigator might do while looking over the astronaut's shoulder. In its original application, [PI] mimicked several of the tasks of the Principal Investigator, including data quality monitoring, troubleshooting, prescheduling, protocol management and "interesting data" detection. The proposed research focuses on the efficacy of this technique as applied to the data quality monitoring and troubleshooting aspects of [PI].

Human Research Program: Long Duration, Exploration-Class Mission Training Design

NASA Technical Reports Server (NTRS)

Barshi, Immanuel; Dempsey, Donna L.

2016-01-01

This is a presentation to the International Training Control Board that oversees astronaut training for ISS. The presentation explains the structure of HRP, the training-related work happening under the different program elements, and discusses in detail the research plan for the Training Risk under SHFHSHFE. The group includes the crew training leads for all the space agencies involved in ISS: Japan, Europe, Russia, Canada, and the US.

NASA Advanced Explorations Systems: 2017 Advancements in Life Support Systems

NASA Technical Reports Server (NTRS)

Schneider, Walter F.; Shull, Sarah A.

2017-01-01

The NASA Advanced Exploration Systems (AES) Life Support Systems (LSS) project strives to develop reliable, energy-efficient, and low-mass spacecraft systems to provide environmental control and life support systems (ECLSS) critical to enabling long duration human missions beyond low Earth orbit (LEO). Highly reliable, closed-loop life support systems are among the capabilities required for the longer duration human space exploration missions planned in the mid-2020s and beyond. The LSS Project is focused on four are-as-architecture and systems engineering for life support systems, environmental monitoring, air revitalization, and wastewater processing and water management. Starting with the International Space Station (ISS) LSS systems as a point of departure where applicable, the three-fold mission of the LSS Project is to address discrete LSS technology gaps, to improve the reliability of LSS systems, and to advance LSS systems toward integrated testing aboard the ISS. This paper is a follow on to the AES LSS development status reported in 2016 and provides additional details on the progress made since that paper was published with specific attention to the status of the Aerosol Sampler ISS Flight Experiment, the Spacecraft Atmosphere Monitor (SAM) Flight Experiment, the Brine Processor Assembly (BPA) Flight Experiment, the CO2 removal technology development tasks, and the work investigating the impacts of dormancy on LSS systems.

Assessing Group Dynamics in a Mars Simulation

NASA Astrophysics Data System (ADS)

Bishop, S. L.

2007-10-01

International interest in psychosocial functioning generally and issues of group and inter-group function for space crews has increased as focus has shifted towards longer duration spaceflight and, particularly, the issues involved in sending a human crew to Mars (Kanas, et al., 2001; Dawson, 2002). Planning documents for a human mission to Mars such as the NASA Design Reference Mission (DRM 1.0) emphasize the need for adaptability of crewmembers and autonomy in the crew as a whole (Hoffman and Kaplan, 1997). Similarly a major study by the International Space University (ISU, 1991) emphasized the need for autonomy and initiative for a Mars crew given that many of the scenarios that will be encountered on Mars cannot be rehearsed on earth and given the lack of any realistic possibility for rescue of the crew. This research project was only one subset of data collected during the larger AustroMars Expedition at the Mars Desert Research Facility (MDRS) in 2006. The participating crew comprises part of a multi-year investigation on teams utilizing the MDRS facility. The program of research has included numerous researchers since 2002 with a progressive evolution of key foci addressing stress, personality, coping, adaptation, cognitive functioning, and group identity assessed across the duration period of the individual missions.

Fabrication of Lightweight Radiation Shielding Composite Materials by Field Assisted Sintering Technique (FAST)

NASA Technical Reports Server (NTRS)

Prasad, Narasimha; Trivedi, Sudhir; Chen, Henry; Kutcher, Susan; Zhang, Dajie; Singh, Jogender

2017-01-01

Advances in radiation shielding technologies are needed to protect humans and electronic components from all threats of space radiation over long durations. In this paper, we report on the use of the innovative and novel fabrication technology known as Field Assisted Sintering Technology (FAST) to fabricate lightweight material with enhanced radiation shielding strength to safeguard humans and electronics suitable for next generation space exploration missions. The base materials we investigated were aluminum (Al), the current standard material for space hardware, and Ultra-High Molecular Weight Polyethylene (UHMWPE), which has high hydrogen content and resistance to nuclear reaction from neutrons, making it a good shielding material for both gamma radiation and particles. UHMWPE also has high resistance to corrosive chemicals, extremely low moisture sensitivity, very low coefficient of friction, and high resistance to abrasion. We reinforced the base materials by adding high density (ie, high atomic weight) metallic material into the composite. These filler materials included: boron carbide (B4C), tungsten (W), tungsten carbide (WC) and gadolinium (Gd).

An overview of Japanese CELSS research activities

NASA Technical Reports Server (NTRS)

Nitta, Keiji

1987-01-01

Development of Controlled Ecological Life Support System (CELSS) technology is inevitable for future long duration stays of human beings in space, for lunar base construction and for manned Mars flight programs. CELSS functions can be divided into 2 categories, Environmental Control and Material Recycling. Temperature, humidity, total atmospheric pressure and partial pressure of oxygen and carbon dioxide, necessary for all living things, are to be controlled by the environment control function. This function can be performed by technologies already developed and used as the Environment Control Life Support System (ECLSS) of Space Shuttle and Space Station. As for material recycling, matured technologies have not yet been established for fully satisfying the specific metabolic requirements of each living thing including human beings. Therefore, research activities for establishing CELSS technology should be focused on material recycling technologies using biological systems such as plants and animals and physico-chemical systems, for example, a gas recycling system, a water purifying and recycling system and a waste management system. Japanese research activities were conducted and will be continued accordingly.

Getting Out of Orbit: Water Recycling Requirements and Technology Needs for Long Duration Missions Away from Earth

NASA Technical Reports Server (NTRS)

Barta, Daniel J.

2017-01-01

Deep-space crewed missions will not have regular access to the Earth's resources or the ability to rapidly return to Earth if a system fails. As crewed missions extend farther from Earth for longer periods, habitation systems must become more self-sufficient and reliable for safe, healthy, and sustainable human exploration. For human missions to Mars, Environmental Control and Life Support Systems (ECLSS) must be able operate for up to 1,100 days with minimal spares and consumables. These missions will require capabilities to more fully recycle atmospheric gases and wastewater to substantially reduce mission costs. Even with relatively austere requirements for use, water represents one of the largest consumables by mass. Systems must be available to extract and recycle water from all sources of waste. And given that there will be no opportunity to send samples back to Earth for analysis, analytical measurements will be limited to monitoring hardware brought on board the spacecraft. The Earth Reliant phase of NASA's exploration strategy includes leveraging the International Space Station (ISS) to demonstrate advanced capabilities for a robust and reliable ECLSS. The ISS Water Recovery System (WRS) includes a Urine Processor Assembly (UPA) for distillation and recovery of water from urine and a Water Processor Assembly (WPA) to process humidity condensate and urine distillate into potable water. Possible enhancements to more fully "close the water loop" include recovery of water from waste brines and solid wastes. A possible game changer is the recovery of water from local planetary resources through use of In Situ Resource Utilization (ISRU) technologies. As part of the development and demonstration sequence, NASA intends to utilize cis-Lunar space as a Proving Ground to verify systems for deep space habitation by conducting extended duration missions to validate our readiness for Mars.

Space Radiation Protection, Space Weather, and Exploration

NASA Technical Reports Server (NTRS)

Zapp, Neal; Fry, Dan; Lee, Kerry

2010-01-01

Management of crew exposure to radiation is a major concern for manned spaceflight and will be even more important for the modern concept of longer-duration exploration. The inherent protection afforded to astronauts by the magnetic field of the Earth in Low Earth Orbit (LEO) makes operations on the space shuttle or space station very different from operations during a deep space exploration mission. In order to experience significant radiation-derived Loss of Mission (LOM) or Loss of Crew (LOC) risk for LEO operations, one is almost driven to dictate extreme duration or to dictate an extreme sequence of solar activity. Outside of the geo-magnetosphere, however, this scenario changes dramatically. Exposures to the same event on the ISS and on the surface of the Moon may differ by multiple orders of magnitude. This change in magnitude, coupled with the logistical constraints present in implementing any practical operational mitigation make situational awareness with regard to space weather a limiting factor for our ability to conduct exploration operations. With these differences in risk to crew, vehicle and mission in mind, we present the status of the efforts currently underway as the required development to enable exploration operations. The changes in the operating environment as crewed operations begin to stretch away from the Earth are changing the way we think about the lines between research and operations . The real, practical work to enable a permanent human presence away from Earth has already begun

Effects of Sex and Gender on Adaptation to Space: Behavioral Health

PubMed Central

Bale, Tracy L.; Epperson, C. Neill; Kornstein, Susan G.; Leon, Gloria R.; Palinkas, Lawrence A.; Stuster, Jack W.; Dinges, David F.

2014-01-01

Abstract This article is part of a larger body of work entitled, “The Impact of Sex and Gender on Adaptation to Space.” It was developed in response to a recommendation from the 2011 National Academy of Sciences Decadal Survey, “Recapturing a Future for Space Exploration: Life and Physical Sciences for a New Era,” which emphasized the need to fully understand sex and gender differences. In this article, our workgroup—consisting of expert scientists and clinicians from academia and the private sector—investigated and summarized the current body of published and unpublished human research performed to date related to sex- and gender-based differences in behavioral adaptations to human spaceflight. This review identifies sex-related differences in: (1) sleep, circadian rhythms, and neurobehavioral measures; (2) personality, group interactions, and work performance and satisfaction; and (3) stress and clinical disorders. Differences in these areas substantially impact the risks and optimal medical care required by space-faring women. To ensure the health and safety of male and female astronauts during long-duration space missions, it is imperative to understand the influences that sex and gender have on behavioral health changes occurring during spaceflight. PMID:25259837

Concepts and challenges in cancer risk prediction for the space radiation environment.

PubMed

Barcellos-Hoff, Mary Helen; Blakely, Eleanor A; Burma, Sandeep; Fornace, Albert J; Gerson, Stanton; Hlatky, Lynn; Kirsch, David G; Luderer, Ulrike; Shay, Jerry; Wang, Ya; Weil, Michael M

2015-07-01

Cancer is an important long-term risk for astronauts exposed to protons and high-energy charged particles during travel and residence on asteroids, the moon, and other planets. NASA's Biomedical Critical Path Roadmap defines the carcinogenic risks of radiation exposure as one of four type I risks. A type I risk represents a demonstrated, serious problem with no countermeasure concepts, and may be a potential "show-stopper" for long duration spaceflight. Estimating the carcinogenic risks for humans who will be exposed to heavy ions during deep space exploration has very large uncertainties at present. There are no human data that address risk from extended exposure to complex radiation fields. The overarching goal in this area to improve risk modeling is to provide biological insight and mechanistic analysis of radiation quality effects on carcinogenesis. Understanding mechanisms will provide routes to modeling and predicting risk and designing countermeasures. This white paper reviews broad issues related to experimental models and concepts in space radiation carcinogenesis as well as the current state of the field to place into context recent findings and concepts derived from the NASA Space Radiation Program. Copyright © 2015 The Committee on Space Research (COSPAR). Published by Elsevier Ltd. All rights reserved.

NASA food systems: past, present, and future

NASA Technical Reports Server (NTRS)

Perchonok, Michele; Bourland, Charles

2002-01-01

The development of space food has been evolving since the Soviet cosmonaut, German Titov, became the first human to eat in space in August 1961. John Glenn was the first American to consume food, applesauce, on the third manned Mercury mission in August 1962. Before these events, there was no knowledge that humans would be able to swallow and, hence, eat in weightlessness. Space food development began with highly engineered foods that met rigid requirements imposed by spacecraft design and short mission durations. Improvements in the habitability of the spacecraft have permitted improvements in the quality of space food. As the missions became longer, the need for better nutrition, more variety, and easily consumable foods also became more important. Currently, the International Space Station astronauts have a wide variety of foods. The goal is to provide acceptable foods that taste similar to foods we eat here on Earth. Extended planetary stays will require even more variety and more technologic advances. Plants will be grown to recycle the air and water and will provide food for the crew. These harvested crops will need to be processed into safe, healthy, and acceptable food ingredients that can then be prepared into menu items.

Effects of sex and gender on adaptation to space: behavioral health.

PubMed

Goel, Namni; Bale, Tracy L; Epperson, C Neill; Kornstein, Susan G; Leon, Gloria R; Palinkas, Lawrence A; Stuster, Jack W; Dinges, David F

2014-11-01

This article is part of a larger body of work entitled, "The Impact of Sex and Gender on Adaptation to Space." It was developed in response to a recommendation from the 2011 National Academy of Sciences Decadal Survey, "Recapturing a Future for Space Exploration: Life and Physical Sciences for a New Era," which emphasized the need to fully understand sex and gender differences. In this article, our workgroup-consisting of expert scientists and clinicians from academia and the private sector-investigated and summarized the current body of published and unpublished human research performed to date related to sex- and gender-based differences in behavioral adaptations to human spaceflight. This review identifies sex-related differences in: (1) sleep, circadian rhythms, and neurobehavioral measures; (2) personality, group interactions, and work performance and satisfaction; and (3) stress and clinical disorders. Differences in these areas substantially impact the risks and optimal medical care required by space-faring women. To ensure the health and safety of male and female astronauts during long-duration space missions, it is imperative to understand the influences that sex and gender have on behavioral health changes occurring during spaceflight.

Biological Rhythms Modelisation of Vigilance and Sleep in Microgravity State with COSINOR and Volterra's Kernels Methods

NASA Astrophysics Data System (ADS)

Gaudeua de Gerlicz, C.; Golding, J. G.; Bobola, Ph.; Moutarde, C.; Naji, S.

2008-06-01

The spaceflight under microgravity cause basically biological and physiological imbalance in human being. Lot of study has been yet release on this topic especially about sleep disturbances and on the circadian rhythms (alternation vigilance-sleep, body, temperature...). Factors like space motion sickness, noise, or excitement can cause severe sleep disturbances. For a stay of longer than four months in space, gradual increases in the planned duration of sleep were reported. [1] The average sleep in orbit was more than 1.5 hours shorter than the during control periods on earth, where sleep averaged 7.9 hours. [2] Alertness and calmness were unregistered yield clear circadian pattern of 24h but with a phase delay of 4h.The calmness showed a biphasic component (12h) mean sleep duration was 6.4 structured by 3-5 non REM/REM cycles. Modelisations of neurophysiologic mechanisms of stress and interactions between various physiological and psychological variables of rhythms have can be yet release with the COSINOR method. [3

Introduction

NASA Astrophysics Data System (ADS)

Gaskin, J. A.; Smith, I. S.; Jones, W. V.

In 1783, the Montgolfier brothers ushered in a new era of transportation and exploration when they used hot air to drive an un-tethered balloon to an altitude of 2 km. Made of sackcloth and held together with cords, this balloon challenged the way we thought about human travel, and it has since evolved into a robust platform for performing novel science and testing new technologies. Today, high-altitude balloons regularly reach altitudes of 40 km, and they can support payloads that weigh more than 3000 kg. Long-duration balloons can currently support mission durations lasting 55 days, and developing balloon technologies (i.e. Super-Pressure Balloons) are expected to extend that duration to 100 days or longer; competing with satellite payloads. This relatively inexpensive platform supports a broad range of science payloads, spanning multiple disciplines (astrophysics, heliophysics, planetary and earth science). Applications extending beyond traditional science include testing new technologies for eventual space-based application and stratospheric airships for planetary applications.

Closure of regenerative life support systems: results of the Lunar-Mars Life Support Test Project

NASA Astrophysics Data System (ADS)

Barta, D.; Henninger, D.; Edeen, M.; Lewis, J.; Smith, F.; Verostko, C.

Future long duration human exploration missions away from Earth will require closed-loop regenerative life support systems to reduce launch mass reduce dependency on resupply and increase the level of mission self sufficiency Such systems may be based on the integration of biological and physiocochemical processes to produce potable water breathable atmosphere and nutritious food from metabolic and other mission wastes Over the period 1995 to 1998 a series of ground-based tests were conducted at the National Aeronautics and Space Administration Johnson Space Center to evaluate the performance of advanced closed-loop life support technologies with real human metabolic and hygiene loads Named the Lunar-Mars Life Support Test Project LMLSTP four integrated human tests were conducted with increasing duration complexity and closure The first test LMLSTP Phase I was designed to demonstrate the ability of higher plants to revitalize cabin atmosphere A single crew member spent 15 days within an atmospherically closed chamber containing 11 2 square meters of actively growing wheat Atmospheric carbon dioxide and oxygen levels were maintained by control of the rate of photosynthesis through manipulation of light intensity or the availability of carbon dioxide and included integrated physicochemical systems During the second and third tests LMLSTP Phases II IIa four crew members spent 30 days and 60 days respectively in a larger sealed chamber Advanced physicochemical life support hardware was used to regenerate the atmosphere and produce potable water

Combustion, Complex Fluids, and Fluid Physics Experiments on the ISS

NASA Technical Reports Server (NTRS)

Motil, Brian; Urban, David

2012-01-01

From the very early days of human spaceflight, NASA has been conducting experiments in space to understand the effect of weightlessness on physical and chemically reacting systems. NASA Glenn Research Center (GRC) in Cleveland, Ohio has been at the forefront of this research looking at both fundamental studies in microgravity as well as experiments targeted at reducing the risks to long duration human missions to the moon, Mars, and beyond. In the current International Space Station (ISS) era, we now have an orbiting laboratory that provides the highly desired condition of long-duration microgravity. This allows continuous and interactive research similar to Earth-based laboratories. Because of these capabilities, the ISS is an indispensible laboratory for low gravity research. NASA GRC has been actively involved in developing and operating facilities and experiments on the ISS since the beginning of a permanent human presence on November 2, 2000. As the lead Center for combustion, complex fluids, and fluid physics; GRC has led the successful implementation of the Combustion Integrated Rack (CIR) and the Fluids Integrated Rack (FIR) as well as the continued use of other facilities on the ISS. These facilities have supported combustion experiments in fundamental droplet combustion; fire detection; fire extinguishment; soot phenomena; flame liftoff and stability; and material flammability. The fluids experiments have studied capillary flow; magneto-rheological fluids; colloidal systems; extensional rheology; pool and nucleate boiling phenomena. In this paper, we provide an overview of the experiments conducted on the ISS over the past 12 years.

High-Temperature, Thin-Film Ceramic Thermocouples Developed

NASA Technical Reports Server (NTRS)

Sayir, Ali; Blaha, Charles A.; Gonzalez, Jose M.

2005-01-01

To enable long-duration, more distant human and robotic missions for the Vision for Space Exploration, as well as safer, lighter, quieter, and more fuel efficient vehicles for aeronautics and space transportation, NASA is developing instrumentation and material technologies. The high-temperature capabilities of thin-film ceramic thermocouples are being explored at the NASA Glenn Research Center by the Sensors and Electronics Branch and the Ceramics Branch in partnership with Case Western Reserve University (CWRU). Glenn s Sensors and Electronics Branch is developing thin-film sensors for surface measurement of strain, temperature, heat flux, and surface flow in propulsion system research. Glenn s Ceramics Branch, in conjunction with CWRU, is developing structural and functional ceramic technology for aeropropulsion and space propulsion.

Psychosocial issues in space: future challenges.

PubMed

Sandal, G M

2001-06-01

As the duration of space flights increases and crews become more heterogeneous, psychosocial factors are likely to play an increasingly important role in determining mission success. The operations of the International Space Station and planning of interplanetary missions represent important future challenges for how to select, train and monitor crews. So far, empirical evidence about psychological factors in space is based on simulations and personnel in analog environments (i.e. polar expeditions, submarines). It is apparent that attempts to transfer from these environments to space requires a thorough analysis of the human behavior specific to the fields. Recommendations for research include the effects of multi-nationality on crew interaction, development of tension within crews and between Mission Control, and prediction of critical phases in adaptation over time. Selection of interpersonally compatible crews, pre-mission team training and implementation of tools for self-monitoring of psychological parameters ensure that changes in mission requirements maximize crew performance.

Report on ESA Topical Team on the Large Radius Human Centrifuge: "The Human Hypergravity Habitat; H3"

NASA Astrophysics Data System (ADS)

van Loon, Jack J. W. A.; Bücker, N.; Berte, J.; Bok, K.; Bos, J.; Boyle, R.; Bravenoer, N.; Chouker, A.; Clement, G.; Cras, P.; Denise, D.; Eekhoff, M.; Felsenberg, D.; Fong, K.; Fuller, C.; Groen, E.; Heer, M.; Hinghofer-Szalkay, H.; Iwase, S.; Karemaker, J. M.; Linnarsson, D.; Lüthen, C.; Narici, M.; Norsk, P.; Paloski, W.; Rutten, M.; Saggini, R.; Stephan, A.; Ullrich, O.; Vautmans, V.; Wuyts, F.; Young, L.

Over the last decades a significant amount of knowledge has been accumulated on the adap-tation of the human body going into near weightless conditions and on its re-adaptation to 1g Earth conditions after space flight. Ground-based paradigms for microgravity simulation have been developed such as head down tilted bed rest and dry-immersion. In such systems the adaptations to long term immobilization and to head-ward fluid shifts have been studied. Questions we address here are: can long-term ground-based centrifugation help us to under-stand and even predict the adaptations to long-term increased gravity conditions? How does the body adapt to chronic (days, weeks or longer) exposure to a hypergravity environment? And, once the body has fully adapted to a hypergravity environment, how does it re-adapt going from a hypergravity state back to a relatively hypo-gravity condition of 1g, or even going from a centrifuge / hypergravity environment into a bed-rest setting? Can such transitions in well-controlled studies bring us closer to understanding the consequences of gravity transitions that the crews will likely experience going to the Moon or to Mars. Is hypergravity a good model to study the effect of re-entry in gravitational environments after long duration space flight? In an ESA -supported Topical Team we address all organ systems known so far to change directly or indirectly by altered gravity conditions. We will identify to which gravity levels the human body can be exposed for longer periods of time and what protocols could be applied to address the questions at hand. We also identify the technology required to ac-complish such long duration hypergravity and re-adaptation studies. Issues like ethics, safety and required logistics should be addressed. As there is limited experience with exposure of hu-man test subjects to prolonged periods of moderately increased g-forces, unexpected harm may occur. Therefore, the information, disclosure and informed consent procedures need special attention. The final outcome of the Topical Team will be a clear answer about the feasibility of the use of hypergravity as a tool and analogue for space research, and if and how hypergravity studies can provide useful knowledge to support future space flight on the one hand and current medical issues in the ageing population (osteoporosis, cardiovascular diseases, obesity) on the other hand.

Advancing Translational Space Research Through Biospecimen Sharing: Amplifying the Impact of Ground-Based Studies

NASA Technical Reports Server (NTRS)

Ronca, A.; Lewis, L.; Staten, B.; Moyer, E.; Vizir, V.; Gompf, H.; Hoban-Higgins, T.; Fuller, C. A.

2017-01-01

Biospecimen Sharing Programs (BSPs) have been organized by NASA Ames Research Center since the 1960s with the goal of maximizing utilization and scientific return from rare, complex and costly spaceflight experiments. BSPs involve acquiring otherwise unused biological specimens from primary space research experiments for distribution to secondary experiments. Here we describe a collaboration leveraging Ames expertise in biospecimen sharing to magnify the scientific impact of research informing astronaut health funded by the NASA Human Research Program (HRP) Human Health Countermeasures (HHC) Element. The concept expands biospecimen sharing to one-off ground-based studies utilizing analogue space platforms (e.g., Hind limb Unloading (HLU), Artificial Gravity) for rodent experiments, thereby significantly broadening the range of research opportunities with translational relevance for protecting human health in space and on Earth. In this presentation, we will report on biospecimens currently being acquired from HHC Award Head-Down Tilt as a Model for Intracranial and Intraocular Pressures, and Retinal Changes during Spaceflight, and their availability. The BSP add-on to the project described herein has already yielded for HHC-funded investigators more than 4,700 additional tissues that would otherwise have been discarded as waste, with additional tissues available for analysis. Young (3-mo old) male and female rats and Older (9-mo old) male rats are being exposed to HLU for either 7, 14, 28, or 90 days. Additional groups are exposed to 90 days of unloading followed by either 7, 14, 28 days or 90 days of recovery (normal loading). Comparisons are made with non-suspended controls. Unused tissues are: Skin, Lungs, Thymus, Adrenals, Kidneys, Spleen, Hindlimb Muscles (Soleus, Extensor Digitorum Longus, Tibialis Anterior, Plantaris Gastrocnemius), Fat Pads, Reproductive Organs, and Intestines. Tissues are harvested, weighed, preserved then archived (with metadata) using a sample tracking system (CryoTrack). Preservation techniques include snap-freezing and RNALatersnap-freezing. Specimens were weighed at the time of dissection, and organ mass: body mass ratios analyzed to determine unloading effects across conditions and durations. The results corroborate previously reported effects of short-term exposure to microgravity or unloading exposure on various organs, and provide new insights into adaptation to long-duration unloading relevant to sustained spaceflight exposures on ISS. Supported by the Human Research Program (HRP) Human Health Countermeasures (HHC) Element and NASA Grant NNX13AD94G (CAF).

Short-duration spaceflight impairs human carotid baroreceptor-cardiac reflex responses

NASA Astrophysics Data System (ADS)

Fritsch, Janice M.; Charles, John B.; Bennett, Barbara S.; Jones, Michele M.; Eckberg, Dwain L.

1992-08-01

The effect of a spaceflight on the vagally mediated baroreceptor-cardiac reflex responses of humans were investigated by measuring the responses (provoked by neck pressure changes) in supine position and the heart rate and blood pressure in the supine and standing positions in 16 astronauts before and after 4- to 5-day long Space Shuttle missions. The results showed that exposures to spaceflight resulted in reduced baseline levels of the vagal-cardiac outflow and the vagally mediated responses to changes of the arterial baroreceptor input and that these changes contribute to postflight reductions of astronauts' ability to maintain standing arterial pressures.

Survey of On-Orbit Sleep Quality: Short-Duration Flyers

NASA Technical Reports Server (NTRS)

Locke, J.; Leveton, L.; Keeton, K.; Whitmire, A.; Patterson, H.; Faulk, J.

2010-01-01

The NASA Human Research Program (HRP) Behavioral Health and Performance Element (BHP), in conjunction with the NASA Space Medicine Division, is currently completing the largest systematic, subjective assessment of shuttle astronauts sleep behaviors and sleep quality on Earth, during training periods, and during space flight missions. Since July 2009, a total of 66 astronauts have completed a secure online survey regarding specific sleep strategies, crew policies, and mitigation effectiveness. In addition to the survey, each astronaut participant met individually with trained BHP and SD representatives for a structured, follow-up interview. Data are currently being assessed and the study s principal investigator will be providing some preliminary findings at the Investigators Workshop. Additional analyses will be conducted in the following months to examine predictors of optimal sleep in space, and to evaluate the differences in countermeasure effectiveness between groups based on their sleep experience on the ground and on orbit. A revised survey for a subsequent investigation on the experiences of long-duration flyers will be developed in the Spring and implemented in the Summer of 2010. Findings from both of these investigations will inform countermeasure strategies for astronauts, medical operations, and habitat designers for future exploration missions, as well as upcoming shuttle and ISS missions.

Fifty years of human space travel: implications for bone and calcium research.

PubMed

Smith, S M; Abrams, S A; Davis-Street, J E; Heer, M; O'Brien, K O; Wastney, M E; Zwart, S R

2014-01-01

Calcium and bone metabolism remain key concerns for space travelers, and ground-based models of space flight have provided a vast literature to complement the smaller set of reports from flight studies. Increased bone resorption and largely unchanged bone formation result in the loss of calcium and bone mineral during space flight, which alters the endocrine regulation of calcium metabolism. Physical, pharmacologic, and nutritional means have been used to counteract these changes. In 2012, heavy resistance exercise plus good nutritional and vitamin D status were demonstrated to reduce loss of bone mineral density on long-duration International Space Station missions. Uncertainty continues to exist, however, as to whether the bone is as strong after flight as it was before flight and whether nutritional and exercise prescriptions can be optimized during space flight. Findings from these studies not only will help future space explorers but also will broaden our understanding of the regulation of bone and calcium homeostasis on Earth.

Dosimetry of a Deep-Space (Mars) Mission using Measurements from RAD on the Mars Science Laboratory

NASA Astrophysics Data System (ADS)

Hassler, D.; Zeitlin, C.; Ehresmann, B.; Wimmer-Schweingruber, R. F.; Guo, J.; Matthiae, D.; Reitz, G.

2017-12-01

The space radiation environment is one of the outstanding challenges of a manned deep-space mission to Mars. To improve our understanding and take us one step closer to enabling a human Mars to mission, the Radiation Assessment Detector (RAD) on the Mars Science Laboratory (MSL) has been characterizing the radiation environment, both during cruise and on the surface of Mars for the past 5 years. Perhaps the most significant difference between space radiation and radiation exposures from terrestrial exposures is that space radiation includes a significant component of heavy ions from Galactic Cosmic Rays (GCRs). Acute exposures from Solar Energetic Particles (SEPs) are possible during and around solar maximum, but the energies from SEPs are generally lower and more easily shielded. Thus the greater concern for long duration deep-space missions is the GCR exposure. In this presentation, I will review the the past 5 years of MSL RAD observations and discuss current approaches to radiation risk estimation used by NASA and other space agencies.

[Comparative analysis of cosmonauts skeleton changes after space flights on orbital station Mir and international space station and possibilities of prognosis for interplanetary missions].

PubMed

Oganov, V S; Bogomolov, V V; Bakulin, A V; Novikov, V E; Kabitskaia, O E; Murashko, L M; Morgun, V V; Kasparskiĭ, R R

2010-01-01

A summary of investigations results of human bone tissue changes in space flight on the orbital station (OS) Mir and international space station (ISS) using dual energy X-ray absorptiometry (DXA) is given. Results comparative analysis revealed an absence of significant differences in bone mass (BM) changes on the both OS. Theoretically expected BM loss was observed in bone trabecular structure of skeleton low part after space flight lasting 5-7 month. The BM losses are qualified in some cases as quicly developed but reversible osteopenia and generally interpreted as evidence of bone functional adaptation to the alterating mechanical loading. It was demonstrated the high individual variability BM loss amplitudes. Simultaneously was observed the individual pattern of BM loss distribution across different segments of skeleton after repetitive flights independently upon type of OS. In according with the above mentioned individual peculiarities it was impossible to establish the dependence of BM changes upon duration of space missions. Therefore we have not sufficiently data for calculation of probability to achive the critical demineralization level by the augmentation the space mission duration till 1.5-2 years. It is more less possibility of the bone quality changes prognosis, which in the aggregate with BM losses determines the bone fracture risk. It become clearly that DXA technology is unsuffitiently for this purpose. It is considered the main direction which may optimized the elaboration of the interplanetary project meaning the perfectly safe of skeleton mechanical function.

Effects of Nuclear Cross Sections at Different Energies on the Radiation Hazard from Galactic Cosmic Rays

NASA Technical Reports Server (NTRS)

Lin, Z. W.; Adams, J. H., Jr.

2006-01-01

The radiation hazard for astronauts from galactic cosmic rays is a major obstacle in long duration human space explorations. Space radiation transport codes have been developed to calculate radiation environment on missions to the Moon, Mars or beyond. We have studied how uncertainties in fragmentation cross sections at different energies affect the accuracy of predictions from such radiation transport. We find that, in deep space, cross sections between 0.3 and 0.85 GeV/u usually have the largest effect on dose-equivalent behind shielding in solar minimum GCR environments, and cross sections between 0.85 and 1.2 GeV/u have the largest effect in solar maximum GCR environments. At the International Space Station, cross sections at higher energies have the largest effect due to the geomagnetic cutoff.

Activation of microcarrier-attached lymphocytes in microgravity

NASA Technical Reports Server (NTRS)

Bechler, B.; Cogoli, A.; Cogoli-Greuter, M.; Muller, O.; Hunzinger, E.; Criswell, S. B.

1992-01-01

A technology has been developed to achieve optimal attachment of adhesion-independent lymphocytes to microcarrier beads. The activation of T-lymphocytes by concanavalin A was tested under microgravity conditions in an experiment carried out in space during the first Spacelab Life Science Mission. Activation, measured as the synthesis of deoxyribonucleic acid (DNA) and the production of interferon-gamma, more than doubled in attached lymphocytes in microgravity. The depression of the activation discovered in previous space experiments is due to an impairment not of the lymphocyte but of the macrophage function. The system described here may be useful for radiobiological investigations on the effect of high-energy particles and for testing the efficiency of the immune system in humans during the long-duration space flight planned in the future. The biotechnological significance of the increased lymphokine production in space remains to be assessed.

Strategic Implications of Human Exploration of Near-Earth Asteroids

NASA Technical Reports Server (NTRS)

Drake, Bret G.

2011-01-01

The current United States Space Policy [1] as articulated by the White House and later confirmed by the Congress [2] calls for [t]he extension of the human presence from low-Earth orbit to other regions of space beyond low-Earth orbit will enable missions to the surface of the Moon and missions to deep space destinations such as near-Earth asteroids and Mars. Human exploration of the Moon and Mars has been the focus of numerous exhaustive studies and planning, but missions to Near-Earth Asteroids (NEAs) has, by comparison, garnered relatively little attention in terms of mission and systems planning. This paper examines the strategic implications of human exploration of NEAs and how they can fit into the overall exploration strategy. This paper specifically addresses how accessible NEAs are in terms of mission duration, technologies required, and overall architecture construct. Example mission architectures utilizing different propulsion technologies such as chemical, nuclear thermal, and solar electric propulsion were formulated to determine resulting figures of merit including number of NEAs accessible, time of flight, mission mass, number of departure windows, and length of the launch windows. These data, in conjunction with what we currently know about these potential exploration targets (or need to know in the future), provide key insights necessary for future mission and strategic planning.

Embryo Space Colonisation to Overcome the Interstellar Time Distance Bottleneck

NASA Astrophysics Data System (ADS)

Crowl, A.; Hunt, J.; Hein, A. M.

The immense distances to neighbouring star systems pose the single greatest challenge to a true interstellar mission. The challenge is made even greater if the purpose of the mission is scientific in which it is commonly stated that the mission should last no longer than the career of a participating scientist. This imposes speed requirements with a host of well-known problems of propulsion, immense vehicle mass, need for in-space infrastructure, impact hazards, proton flux, and deceleration. If instead the purpose of the interstellar mission is to ensure the survival of humanity by establishing a viable colony using frozen embryos, these many problems are potentially mitigated due to the fact that the speeds can be much slower. Sleeper ships are a suggested low speed alternative, but cosmic ray damage to suspended/frozen humans could place a limit on the acceptable duration of the mission thereby necessitating greater speed with the aforementioned challenges. Near-term solar-sail technology could be sufficient to launch an ESC mission once human ectogenetic technology has matured.

Challenges to Health During Deep Space Exploration Missions

NASA Technical Reports Server (NTRS)

Watkins, S.; Leveton, L.; Norsk, P.; Huff, J.; Shah, R.

2014-01-01

Long duration missions outside of low Earth orbit will present unique challenges to the maintenance of human health. Stressors with physiologic and psychological impacts are inherent in exploration missions, including reduced gravity, increased radiation, isolation, limited habitable volume, circadian disruptions, and cabin atmospheric changes. Operational stressors such as mission timeline and extravehicular activities must also be considered, and these varied stressors may act in additive or synergistic fashions. Should changes to physiology or behavior manifest as a health condition, the rendering of care in an exploration environment must also be considered. Factors such as the clinical background of the crew, inability to evacuate to Earth in a timely manner, communication delay, and limitations in available medical resources will have an impact on the assessment and treatment of these conditions. The presentations associated with this panel will address these unique challenges from the perspective of several elements of the NASA Human Research Program, including Behavioral Health and Performance, Human Health Countermeasures, Space Radiation, and Exploration Medical Capability.

NASA Human Spaceflight Architecture Team Cis-Lunar Analysis

NASA Technical Reports Server (NTRS)

Lupisella, M.; Bobskill, M. R.

2012-01-01

The Cis-Lunar Destination Team of NASA's Human Spaceflight Architecture Teait1 (HAT) has been perfom1ing analyses of a number of cis-lunar locations to infom1 architecture development, transportation and destination elements definition, and operations. The cis-lunar domain is defined as that area of deep space under the gravitation influence of the earth-moon system, including a set of orbital locations (low earth orbit (LEO]. geosynchronous earth orbit [GEO]. highly elliptical orbits [HEO]); earth-moon libration or "Lagrange·· points (EMLl through EMLS, and in particular, EMLI and EML2), and low lunar orbit (LLO). We developed a set of cis-lunar mission concepts defined by mission duration, pre-deployment, type of mission, and location, to develop mission concepts and the associated activities, capabilities, and architecture implications. To date, we have produced two destination operations J concepts based on present human space exploration architectural considerations. We have recently begun defining mission activities that could be conducted within an EM LI or EM L2 facility.

Increased Intracranial Pressure and Visual Impairment Associated with Long-Duration Spaceflight

NASA Technical Reports Server (NTRS)

Marshall-Bowman, Karina

2011-01-01

Although humans have been flying in space since the 1960s, more recent missions have revealed a new suite of physiological adaptations and consequences of space flight. Notably, 60% of long-duration crewmembers (ISS/MIR) and >25% of short-duration (Shuttle) crewmembers have reported subjective degradation in vision (based on debrief comments) (Gibson 2011). Decreased near-visual acuity was demonstrated in 46% of ISS/Mir and 21% of Shuttle crewmembers, resulting in a shift of up to 1-2 diopters in their refractive correction. It is likely that the recently revealed ophthalmic changes have been present since the first days of human space flight, but have been overlooked or attributed to other causations. The reported changes in vision have occurred at various time points throughout missions, with ranging degrees of visual degradation. Although some cases resolved upon return to Earth, several astronauts have not regained preflight visual acuity, indicating that the damage may be permanent. While observing these changes over the years, without other overt symptomology and with the given age range of the flying population, this has largely been attributed to an expected hyperopic shift due to aging. However, the availability of onboard analysis techniques, including visual acuity assessments, retinal imagery, and ultrasounds of the eye and optic nerve tracts, along with more detailed post-flight techniques, has led to the recent recognition of a wider syndrome. Along with vision changes, findings include flattening of the globe, swelling of the optic disc (papilledema), choroidal folds in the retina, swelling of the optic nerve sheath, and visual field defects. It is widely hypothesized that this constellation of findings may be explained by an elevation of intracranial pressure (ICP). Out of the 60% of long-duration astronauts that have reported a subjective degradation in vision, a subset (currently 10 astronauts) have developed this syndrome. The National Aeronautics and Space Administration (NASA) has made it a high priority to understand this syndrome and provide mitigation techniques to protect crewmembers from visual impairment. While there are many possible factors that could contribute to intracranial hypertension associated with spaceflight, the relative contribution of these, as well as the processes by which eye damage occurs as a result of intracranial hypertension, are not fully understood. The observed pathophysiological phenomena are extremely complex and it is likely that multiple factors contribute to their incidence, rather than one simple mechanism. This paper will define and examine the findings in detail, and expound upon the potential contributing factors and their relative contribution to this syndrome.

Planning for long-duration space exploration: Interviews with NASA subject matter experts

NASA Astrophysics Data System (ADS)

McIntosh, Tristan; Mulhearn, Tyler; Gibson, Carter; Mumford, Michael D.; Yammarino, Francis J.; Connelly, Shane; Day, Eric A.; Vessey, William B.

2016-12-01

Planning is critical to organizations, especially for those involved in pursuing technologic, scientific, and innovative ventures. Examination of planning processes is particularly important in high-stake and high-risk environments. In the present study, to highlight the significance of planning in the context of long-duration space missions, 11 current and former National Aeronautics and Space Administration (NASA) personnel were interviewed to gain a better understanding of astronaut and Mission Control leadership in preparing for and carrying out space missions. Interviewees focused their responses on perceptions of leadership and thoughts on how long-duration spaceflight leadership should be different from current and short-term spaceflight. Notes from these interviews were content coded and qualitatively analyzed. We found that cognitive planning skills and case-based reasoning were among the variables that were most highly rated for being critical to the success of long-duration space missions. Moreover, qualitative analyses revealed new considerations for long-duration space missions, such as granting greater autonomy to crewmembers and the need for more near-term forecasting. The implications of these findings for understanding the planning processes and necessary characteristics of individuals tasked with planning are discussed.

Prognostics and health management (PHM) for astronauts: a collaboration project on the International Space Station

NASA Astrophysics Data System (ADS)

Popov, Alexandre; Fink, Wolfgang; Hess, Andrew

2016-05-01

Long-duration missions bring numerous risks that must be understood and mitigated in order to keep astronauts healthy, rather than treat a diagnosed health disorder. Having a limited medical support from mission control center on space exploration missions, crew members need a personal health-tracking tool to predict and assess his/her health risks if no preventive measures are taken. This paper refines a concept employing technologies from Prognostics and Health Management (PHM) for systems, namely real-time health monitoring and condition-based health maintenance with predictive diagnostics capabilities. Mapping particular PHM-based solutions to some Human Health and Performance (HH&P) technology candidates, namely by NASA designation, the Autonomous Medical Decision technology and the Integrated Biomedical Informatics technology, this conceptual paper emphasize key points that make the concept different from that of both current conventional medicine and telemedicine including space medicine. The primary benefit of the technologies development for the HH&P domain is the ability to successfully achieve affordable human space missions to Low Earth Orbit (LEO) and beyond. Space missions on the International Space Station (ISS) program directly contribute to the knowledge base and advancements in the HH&P domain, thanks to continued operations on the ISS, a unique human-tended test platform and the only test bed within the space environment. The concept is to be validated on the ISS, the only "test bed" on which to prepare for future manned exploration missions. The paper authors believe that early self-diagnostic coupled with autonomous identification of proper preventive responses on negative trends are critical in order to keep astronauts healthy.

On the practicality of emergency surgery during long-duration space missions.

PubMed

Dawson, David L

2008-07-01

While discussions of the practicality of surgery in space often focus on technical issues, such as adapting instrumentation and procedures for use in microgravity, programmatic issues need to be addressed if meaningful capabilities for emergency surgery are to be considered for human exploration missions beyond low Earth orbit. Advanced technologies that have been evaluated, including simulation-enhanced training, telementoring, or robotic assistance, might help prepare or augment a crew medical officer, but a physician with advanced training and relevant experience will be needed if surgical capabilities beyond basic emergency aid are to be considered. Specific operational roles for physician-astronauts should be established.

Nutritional Products from Space Research

NASA Technical Reports Server (NTRS)

1996-01-01

Six scientists from Martin Marietta who did research for NASA on algae as food supply, oxygen source and a recycling agent for long duration space travel founded Martek Biosciences Corporation. Martek's main product is Formulaid for infants, an algae-based, vegetable-like oil containing two essential polyunsaturated fatty acids known as DHA (docosahexaenoic acid) and ARA (arachidonic acid). The acids are found in human milk but not in most infant formulas, and they are believed to be associated with mental and visual development. Formulaid is on the market in two European countries and licensed to the Mead Johnson Division of Bristol-Myers Squibb, American Home Products and others.

JSC research and technology

NASA Technical Reports Server (NTRS)

1993-01-01

The primary roles and missions of JSC incorporate all aspects of human presence in space. Therefore, the Center is involved in the development of technology that will allow humans to stay longer in Earth orbit, allow safe flight in space, and provide capabilities to explore the Moon and Mars. The Center's technology emphasis areas include human spacecraft development, human support systems and infrastructure, and human spacecraft operations. Safety and reliability are critical requirements for the technologies that JSC pursues for long-duration use in space. One of the objectives of technology development at the Center is to give employees the opportunity to enhance their technological expertise and project management skills by defining, designing, and developing projects that are vital to the Center's strategy for the future. This report is intended to communicate within and outside the Agency our research and technology (R&T) accomplishments, as well as inform Headquarters program managers and their constituents of the significant accomplishments that have promise for future Agency programs. While not inclusive of all R&T efforts, the report presents a comprehensive summary of JSC projects in which substantial progress was made in the 1992 fiscal year. At the beginning of each project description, names of the Principal Investigator (PI) and the Technical Monitor (TM) are given, followed by their JSC mail codes or their company or university affiliations. The funding sources and technology focal points are identified in the index.

Immune Function and Reactivation of Latent Viruses

NASA Technical Reports Server (NTRS)

Butel, Janet S.

1999-01-01

A major concern associated with long-duration space flight is the possibility of infectious diseases posing an unacceptable medical risk to crew members. One major hypothesis addressed in this project is that space flight will cause alterations in the immune system that will allow latent viruses that are endogenous in the human population to reactivate and shed to higher levels than normal, which may affect the health of crew members. The second major hypothesis being examined is that the effects of space flight will alter the mucosal immune system, the first line of defense against many microbial infections, including herpesviruses, polyomaviruses, and gastroenteritis viruses, rendering crew members more susceptible to virus infections across the mucosa. We are focusing the virus studies on the human herpesviruses and polyomaviruses, important pathogens known to establish latent infections in most of the human population. Both primary infection and reactivation from latent infection with these groups of viruses (especially certain herpesviruses) can cause a variety of illnesses that result in morbidity and, occasionally, mortality. Both herpesviruses and polyomaviruses have been associated with human cancer, as well. Effective vaccines exist for only one of the eight known human herpesviruses and available antivirals are of limited use. Whereas normal individuals display minimal consequences from latent viral infections, events which alter immune function (such as immunosuppressive therapy following solid organ transplantation) are known to increase the risk of complications as a result of viral reactivations.

Weather Regulates Location, Timing, and Intensity of Dengue Virus Transmission between Humans and Mosquitoes.

PubMed

Campbell, Karen M; Haldeman, Kristin; Lehnig, Chris; Munayco, Cesar V; Halsey, Eric S; Laguna-Torres, V Alberto; Yagui, Martín; Morrison, Amy C; Lin, Chii-Dean; Scott, Thomas W

2015-01-01

Dengue is one of the most aggressively expanding mosquito-transmitted viruses. The human burden approaches 400 million infections annually. Complex transmission dynamics pose challenges for predicting location, timing, and magnitude of risk; thus, models are needed to guide prevention strategies and policy development locally and globally. Weather regulates transmission-potential via its effects on vector dynamics. An important gap in understanding risk and roadblock in model development is an empirical perspective clarifying how weather impacts transmission in diverse ecological settings. We sought to determine if location, timing, and potential-intensity of transmission are systematically defined by weather. We developed a high-resolution empirical profile of the local weather-disease connection across Peru, a country with considerable ecological diversity. Applying 2-dimensional weather-space that pairs temperature versus humidity, we mapped local transmission-potential in weather-space by week during 1994-2012. A binary classification-tree was developed to test whether weather data could classify 1828 Peruvian districts as positive/negative for transmission and into ranks of transmission-potential with respect to observed disease. We show that transmission-potential is regulated by temperature-humidity coupling, enabling epidemics in a limited area of weather-space. Duration within a specific temperature range defines transmission-potential that is amplified exponentially in higher humidity. Dengue-positive districts were identified by mean temperature >22°C for 7+ weeks and minimum temperature >14°C for 33+ weeks annually with 95% sensitivity and specificity. In elevated-risk locations, seasonal peak-incidence occurred when mean temperature was 26-29°C, coincident with humidity at its local maximum; highest incidence when humidity >80%. We profile transmission-potential in weather-space for temperature-humidity ranging 0-38°C and 5-100% at 1°C x 2% resolution. Local duration in limited areas of temperature-humidity weather-space identifies potential locations, timing, and magnitude of transmission. The weather-space profile of transmission-potential provides needed data that define a systematic and highly-sensitive weather-disease connection, demonstrating separate but coupled roles of temperature and humidity. New insights regarding natural regulation of human-mosquito transmission across diverse ecological settings advance our understanding of risk locally and globally for dengue and other mosquito-borne diseases and support advances in public health policy/operations, providing an evidence-base for modeling, predicting risk, and surveillance-prevention planning.

Microbial Impact on Success of Human Exploration Missions

NASA Technical Reports Server (NTRS)

Pierson, Duane L.; Ott, C. Mark; Groves, T. O.; Paloski, W. H. (Technical Monitor)

2000-01-01

The purpose of this study is to identify microbiological risks associated with space exploration and identify potential countermeasures available. Identification of microbial risks associated with space habitation requires knowledge of the sources and expected types of microbial agents. Crew data along with environmental data from water, surfaces, air, and free condensate are utilized in risk examination. Data from terrestrial models are also used. Microbial risks to crew health include bacteria, fungi, protozoa, and viruses. Adverse effects of microbes include: infections, allergic reactions, toxin production, release of volatiles, food spoilage, plant disease, material degradation, and environmental contamination. Risk is difficult to assess because of unknown potential changes in microbes (e.g., mutation) and the human host (e.g., immune changes). Prevention of adverse microbial impacts is preferred over remediation. Preventative measures include engineering measures (e.g., air filtration), crew microbial screening, acceptability standards, and active verification by onboard monitoring. Microbiological agents are important risks to human health and performance during space flight and risks increase with mission duration. Acceptable risk level must be defined. Prevention must be given high priority. Careful screening of crewmembers and payloads is an important element of any risk mitigation plan. Improved quantitation of microbiological risks is a high priority.

International Internship Report for Asher Williams

NASA Technical Reports Server (NTRS)

Williams, Asher

2015-01-01

For the 2015 NASA I (sup 2) Internship Program, I was selected to work in Dr. John Hogan's laboratory on a Human Nutrient Production in Space (Bio-Nutrients) Project involving Research & Development in advanced microbial strategies for the production of nutrients within crewed spacecraft and habitats. Long-term space missions encounter the hurdle of substantial degradation of certain nutrients in food and supplements with time, potentially resulting in nutrient deficiency and serious health problems. The goal of the Bio-Nutrients Project is to enable rapid, safe, and reliable in situ production of needed nutrients using minimal mass, power, and volume. A platform technology is being developed to employ hydratable single-use packets that contain an edible growth medium and a food microbe engineered to produce target human nutrients. In particular, we examined the production of the carotenoids lutein and zeaxanthin in a spore-forming strain of the yeast Saccharomyces cerevisiae. Carotenoids are important antioxidants required for ocular health, a problematic area for some astronauts on long-duration ISS missions...To meet the first-year milestones for the Bio-Nutrients project, my specific task was to design and run preliminary tests on a disposable bioreactor for in situ production of human nutrients in space.

Task and work performance on Skylab missions 2, 3, and 4: Time and motion study: Experiment M151

NASA Technical Reports Server (NTRS)

Kubis, J. F.; Mclaughlin, E. J.; Jackson, J. M.; Rusnak, R.; Mcbride, G. H.; Saxon, S. V.

1977-01-01

Human task performance was evaluated under weightlessness conditions during long duration space flight in order to study the characteristics of the adaptation function. Results show that despite pronounced variability in training schedules and in initial reaction to the Skylab environment, in-flight task performance was relatively equivalent among Skylab crews, and behavioral performance continued to improve from beginning to end of all missions.

Advanced Environmental Monitoring Technologies

NASA Technical Reports Server (NTRS)

Jan, Darrell

2004-01-01

Viewgraphs on Advanced Environmental Monitoring Technologies are presented. The topics include: 1) Monitoring & Controlling the Environment; 2) Illustrative Example: Canary 3) Ground-based Commercial Technology; 4) High Capability & Low Mass/Power + Autonomy = Key to Future SpaceFlight; 5) Current Practice: in Flight; 6) Current Practice: Post Flight; 7) Miniature Mass Spectrometer for Planetary Exploration and Long Duration Human Flight; 8) Hardware and Data Acquisition System; 9) 16S rDNA Phylogenetic Tree; and 10) Preview of Porter.

Investigation of the effects of long duration space exposure on active optical system components

NASA Technical Reports Server (NTRS)

Blue, M. D.

1994-01-01

This experiment was exposed to the space environment for 6 years on the Long Duration Exposure Facility (LDEF). It investigated quantitatively the effects of the long-duration space exposure on the relevant performance parameters of a representative set of electron-optic system components, including lasers, radiation detectors, filters, modulators, windows, and other related components. It evaluated the results and implications of the measurements indicating real or suspected degradation mechanisms. This information will be used to establish guidelines for the selection and use of components for space-based, electro-optic systems.

Salient in space, salient in time: Fixation probability predicts fixation duration during natural scene viewing.

PubMed

Einhäuser, Wolfgang; Nuthmann, Antje

2016-09-01

During natural scene viewing, humans typically attend and fixate selected locations for about 200-400 ms. Two variables characterize such "overt" attention: the probability of a location being fixated, and the fixation's duration. Both variables have been widely researched, but little is known about their relation. We use a two-step approach to investigate the relation between fixation probability and duration. In the first step, we use a large corpus of fixation data. We demonstrate that fixation probability (empirical salience) predicts fixation duration across different observers and tasks. Linear mixed-effects modeling shows that this relation is explained neither by joint dependencies on simple image features (luminance, contrast, edge density) nor by spatial biases (central bias). In the second step, we experimentally manipulate some of these features. We find that fixation probability from the corpus data still predicts fixation duration for this new set of experimental data. This holds even if stimuli are deprived of low-level images features, as long as higher level scene structure remains intact. Together, this shows a robust relation between fixation duration and probability, which does not depend on simple image features. Moreover, the study exemplifies the combination of empirical research on a large corpus of data with targeted experimental manipulations.

Effect of space flights on plasma hormone levels in man and in experimental animal

NASA Astrophysics Data System (ADS)

Macho, L.; Kvetňanský, R.; Vigaš, M.; Németh, S.; Popova, I.; Tigranian, R. A.; Noskov, V. B.; Serova, L.; Grigoriev, I. A.

An important increase of plasma hormone levels like insulin, TSH and aldosterone was observed in human subjects after space flights, however in the changes of plasma content of ACTH, cortisol, adrenaline and noradrenaline the individual variations were observed in relation to number and duration of space flight. For evaluation of the effects of these changes in plasma hormone levels on metabolic processes also the experiments with small animals subjected to space flights on a board of biosatellite of Cosmos series were running. An elevation of plasma levels of corticosterone, adrenaline, noradrenaline and insulin was found in rats after the space flights of duration from 7 to 20 days. It was demonstrated, that the increase of corticosterone in plasma is followed by the activation of enzymes involved in the aminoacid metabolism in rat liver (tyrosine aminotransferase, tryptophanpyrolase, alanine aminotransferase and aspartate aminotransferase). After a short recovery period (2 to 6 days) the plasma corticosterone concentration and also the activity of liver enzymes returned to control levels. The exposition of animals to stress stimuli during this recovery period showed higher response of corticosterone levels in flight rats as compared to intact controls. The increase of plasma catecholamine levels was not followed by elevation of lipolysis in adipose tissue. This is due to lower response of adipose tissue to catecholamine because a decrease of the stimulation of lipolysis by noradrenaline was observed in animals after space flight. The increase of insulin was not followed by adequate decrease of glucose concentration suggesting a disturbances in glucose utilization similarly as in cosmonauts after a long-term space flight. These results showed that changes in plasma hormone levels, observed after space flight, affected the regulation of metabolic processes in tissues.

Cell biology and biotechnology research for exploration of the Moon and Mars

NASA Astrophysics Data System (ADS)

Pellis, N.; North, R.

Health risks generated by human long exposure to radiation, microgravity, and unknown factors in the planetary environment are the major unresolved issues for human space exploration. A complete characterization of human and other biological systems adaptation processes to long-duration space missions is necessary for the development of countermeasures. The utilization of cell and engineered tissue cultures in space research and exploration complements research in human, animal, and plant subjects. We can bring a small number of humans, animals, or plants to the ISS, Moon, and Mars. However, we can investigate millions of their cells during these missions. Furthermore, many experiments can not be performed on humans, e.g. radiation exposure, cardiac muscle. Cells from critical tissues and tissue constructs per se are excellent subjects for experiments that address underlying mechanisms important to countermeasures. The development of cell tissue engineered for replacement, implantation of biomaterial to induce tissue regeneration (e.g. absorbable collagen matrix for guiding tissue regeneration in periodontal surgery), and immunoisolation (e.g. biopolymer coating on transplanted tissues to ward off immunological rejection) are good examples of cell research and biotechnology applications. NASA Cell Biology and Biotechnology research include Bone/Muscle and Cardiovascular cell culture and tissue engineering; Environmental Health and Life Support Systems; Immune System; Radiation; Gravity Thresholds ; and Advanced Biotechnology Development to increase the understanding of animal and plant cell adaptive behavior when exposed to space, and to advance technologies that facilitates exploration. Cell systems can be used to investigate processes related to food, microbial proliferation, waste management, biofilms and biomaterials. The NASA Cell Science Program has the advantage of conducting research in microgravity based on significantly small resources, and the ability to conduct experiments in the early phase of the development of requirements for exploration. Supporting the NASA concept of stepping stones, we believe that ground based, International Space Station, robotic and satellite missions offer the ideal environment to perform experiments and secure answers necessary for human exploration.

Threshold Gravity Determination and Artificial Gravity Studies Using Magnetic Levitation

NASA Technical Reports Server (NTRS)

Ramachandran, N.; Leslie, F.

2005-01-01

What is the threshold gravity (minimum gravity level) required for the nominal functioning of the human system? What dosage is required (magnitude and duration)? Do human cell lines behave differently in microgravity in response to an external stimulus? The critical need for a variable gravity simulator is emphasized by recent experiments on human epithelial cells and lymphocytes on the Space Shuttle clearly showing that cell growth and function are markedly different from those observed terrestrially. Those differences are also dramatic between cells grown in space and those in Rotating Wall Vessels (RWV), or NASA bioreactor often used to simulate microgravity, indicating that although morphological growth patterns (three dimensional growth) can be successfully simulated using RWVs, cell function performance is not reproduced - a critical difference. If cell function is dramatically affected by gravity off-loading, then cell response to stimuli such as radiation, stress, etc. can be very different from terrestrial cell lines. Yet, we have no good gravity simulator for use in study of these phenomena. This represents a profound shortcoming for countermeasures research. We postulate that we can use magnetic levitation of cells and tissue, through the use of strong magnetic fields and field gradients, as a terrestrial microgravity model to study human cells. Specific objectives of the research are: 1. To develop a tried, tested and benchmarked terrestrial microgravity model for cell culture studies; 2. Gravity threshold determination; 3. Dosage (magnitude and duration) of g-level required for nominal functioning of cells; 4. Comparisons of magnetic levitation model to other models such as RWV, hind limb suspension, etc. and 5. Cellular response to reduced gravity levels of Moon and Mars.

The Variable Vector Countermeasure Suit (V2Suit) for space habitation and exploration.

PubMed

Duda, Kevin R; Vasquez, Rebecca A; Middleton, Akil J; Hansberry, Mitchell L; Newman, Dava J; Jacobs, Shane E; West, John J

2015-01-01

The "Variable Vector Countermeasure Suit (V2Suit) for Space Habitation and Exploration" is a novel system concept that provides a platform for integrating sensors and actuators with daily astronaut intravehicular activities to improve health and performance, while reducing the mass and volume of the physiologic adaptation countermeasure systems, as well as the required exercise time during long-duration space exploration missions. The V2Suit system leverages wearable kinematic monitoring technology and uses inertial measurement units (IMUs) and control moment gyroscopes (CMGs) within miniaturized modules placed on body segments to provide a "viscous resistance" during movements against a specified direction of "down"-initially as a countermeasure to the sensorimotor adaptation performance decrements that manifest themselves while living and working in microgravity and during gravitational transitions during long-duration spaceflight, including post-flight recovery and rehabilitation. Several aspects of the V2Suit system concept were explored and simulated prior to developing a brassboard prototype for technology demonstration. This included a system architecture for identifying the key components and their interconnects, initial identification of key human-system integration challenges, development of a simulation architecture for CMG selection and parameter sizing, and the detailed mechanical design and fabrication of a module. The brassboard prototype demonstrates closed-loop control from "down" initialization through CMG actuation, and provides a research platform for human performance evaluations to mitigate sensorimotor adaptation, as well as a tool for determining the performance requirements when used as a musculoskeletal deconditioning countermeasure. This type of countermeasure system also has Earth benefits, particularly in gait or movement stabilization and rehabilitation.

Immune changes during short-duration missions

NASA Technical Reports Server (NTRS)

Taylor, G. R.

1993-01-01

Spaceflight materially influences the immune mechanism of humans and animals. Effects resulting from missions of less than 1 month are examined. Effects from longer missions are discussed in the companion paper by Konstantinova et al. Most immunology studies have involved analyses of subjects and samples from subjects obtained after flight, with the data being compared with similar data obtained before flight. These studies have demonstrated that short-duration missions can result in a postflight depression in blast cell transformation, major changes in cytokine function, and alterations in the relative numbers of immune cell populations. In addition to these post- vs. preflight studies, some data have been produced in flight. However, these in vitro analyses have been less than satisfactory because of differences between in-flight and ground-control conditions. Recently, both the U.S. and Russian space programs have started collecting in-flight, in vivo, cell-mediated immunity data. These studies have confirmed that the human cell-mediated immune system is blunted during spaceflight.

Immune changes during short-duration missions.

PubMed

Taylor, G R

1993-09-01

Spaceflight materially influences the immune mechanism of humans and animals. Effects resulting from missions of less than 1 month are examined. Effects from longer missions are discussed in the companion paper by Konstantinova et al. Most immunology studies have involved analyses of subjects and samples from subjects obtained after flight, with the data being compared with similar data obtained before flight. These studies have demonstrated that short-duration missions can result in a postflight depression in blast cell transformation, major changes in cytokine function, and alterations in the relative numbers of immune cell populations. In addition to these post- vs. preflight studies, some data have been produced in flight. However, these in vitro analyses have been less than satisfactory because of differences between in-flight and ground-control conditions. Recently, both the U.S. and Russian space programs have started collecting in-flight, in vivo, cell-mediated immunity data. These studies have confirmed that the human cell-mediated immune system is blunted during spaceflight.

Physical/chemical closed-loop water-recycling for long-duration missions

NASA Technical Reports Server (NTRS)

Herrmann, Cal C.; Wydeven, Ted

1990-01-01

Water needs, water sources, and means for recycling water are examined in terms appropriate to the water quality requirements of a small crew and spacecraft intended for long duration exploration missions. Inorganic, organic, and biological hazards are estimated for waste water sources. Sensitivities to these hazards for human uses are estimated. The water recycling processes considered are humidity condensation, carbon dioxide reduction, waste oxidation, distillation, reverse osmosis, pervaporation, electrodialysis, ion exchange, carbon sorption, and electrochemical oxidation. Limitations and applications of these processes are evaluated in terms of water quality objectives. Computerized simulation of some of these chemical processes is examined. Recommendations are made for development of new water recycling technology and improvement of existing technology for near term application to life support systems for humans in space. The technological developments are equally applicable to water needs on earth, in regions where extensive water ecycling is needed or where advanced water treatment is essential to meet EPA health standards.

A dual use case study of space technologies for terrestrial medical applications (Conference Presentation)

NASA Astrophysics Data System (ADS)

Cozmuta, Ioana

2017-05-01

Many challenges exist in understanding the human body as a whole, its adaptability, its resilience, its immunological response, its healing and regeneration power. New knowledge is usually obtained by exploring unique conditions and environments and space is one such variable. Primarily, these attributes have been studied in space for the purpose of understanding the effect of the space environment on long duration space travel. However a myriad of lessons learned have emerged that are important for terrestrial medicine problems such as cardiovascular changes, intracranial pressure changes, vision changes, reduced immunity, etc. For medical study purposes, the changes induced by the space environment on the human body are in general fast and predictable; they persist while in the space environment but also revert to the initial pre-flight healthy state upon return to Earth. This provides a unique cycle to study wellness and disease prediction as well as to develop more effective countermeasures for the benefit of people on earth. At a scientific level, the environment of space can be used to develop new lines of investigations and new knowledge to push the terrestrial state of the art (i.e. study of phase diagrams, identification of new system's states, etc). Moreover, the specialized requirements for space medicine have driven advances in terrestrial medical technologies in areas such as monitoring, diagnostic, prevention and treatment. This talk will provide an overview of compelling examples in key areas of interest for terrestrial medical applications.

Cardiac Atrophy and Diastolic Dysfunction During and After Long Duration Spaceflight: Functional Consequences for Orthostatic Intolerance, Exercise Capability and Risk for Cardiac Arrhythmias

NASA Technical Reports Server (NTRS)

Levine, Benjamin D.; Bungo, Michael W.; Platts, Steven H.; Hamilton, Douglas R.; Johnston, Smith L.

2009-01-01

Cardiac Atrophy and Diastolic Dysfunction During and After Long Duration Spaceflight: Functional Consequences for Orthostatic Intolerance, Exercise Capability and Risk for Cardiac Arrhythmias (Integrated Cardiovascular) will quantify the extent of long-duration space flightassociated cardiac atrophy (deterioration) on the International Space Station crewmembers.

KSC-95pc1196

NASA Image and Video Library

2000-05-02

Original photo and caption dated August 14, 1995: "KSC plant physiologist Dr. Gary Stutte (right) and Cheryl Mackowiak harvest potatoes grown in the Biomass Production Chamber of the Controlled Enviornment Life Support System (CELSS in Hangar L at Cape Canaveral Air Station. During a 418-day "human rated" experiment, potato crops grown in the chamber provided the equivalent of a continuous supply of the oxygen for one astronaut, along with 55 percent of that long-duration space flight crew member's caloric food requirements and enough purified water for four astronauts while absorbing their expelled carbon dioxide. The experiment provided data that will help demonstarte the feasibility of the CELSS operating as a bioregenerative life support system for lunar and deep-space missions that can operate independently without the need to carry consumables such as air, water and food, while not requiring the expendable air and water system filters necessary on today's human-piloted spacecraft."

KSC-95pc1197

NASA Image and Video Library

2000-05-02

Original photo and caption dated August 14, 1995: "KSC plant physiologist Dr. Gary Stutte harvests a potato grown in the Biomass Production Chamber of the Controlled environment Life Support system (CELSS) in Hangar L at Cape Canaveral Air Station. During a 418-day "human rated" experiment, potato crops grown in the chamber provided the equivalent of a continuous supply of the oxygen for one astronaut, along with 55 percent of that long-duration space flight crew member's caloric food requirements and enough purified water for four astronauts while absorbing their expelled carbon dioxide. The experiment provided data that will help demonstarte the feasibility of the CELSS operating as a bioregenerative life support system for lunar and deep-space missions that can operate independently without the need to carry consumables such as air, water and food, while not requiring the expendable air and water system filters necessary on today's human-piloted spacecraft."

Remote Collaboration on Task Scheduling for Humans at Mars

NASA Technical Reports Server (NTRS)

Jaap, John; Meyer, Patrick; Davis, Elizabeth; Richardson, Lea

2006-01-01

As humans venture farther from Earth for longer durations, it will become essential for those on the journey to have significant control over the scheduling of their own activities as well as the activities of their companion systems and robots. However, the crew will not do all the scheduling; timelines will be the result of collaboration with ground personnel. Emerging technologies such as in-space message buses, delay-tolerant networks, and in-space internet will be the carriers on which the collaboration rides. Advances in scheduling technology, in the areas of task modeling, scheduling engines, and user interfaces will allow the crew to become virtual scheduling experts. New concepts of operations for producing the timeline will allow the crew and the ground support to collaborate while providing safeguards to ensure that the mission will be effectively accomplished without endangering the systems or personnel.

Three-Dimensional Normal Human Neutral Progenitor Tissue-Like Assemblies: A Model for Persistent Varicella-Zoster Virus Infection and Platform to Study Oxidate Stress and Damage in Multiple Hit Scenarios

NASA Technical Reports Server (NTRS)

Goodwin, Thomas J.; McCarthy, M.; Osterrieder, N.; Cohrs, R. J.; Kaufer, B. B.

2014-01-01

The environment of space results in a multitude of challenges to the human physiology that present barriers to extended habitation and exploration. Over 40 years of investigation to define countermeasures to address space flight adaptation has left gaps in our knowledge regarding mitigation strategies partly due to the lack of investigative tools, monitoring strategies, and real time diagnostics to understand the central causative agent(s) responsible for physiologic adaptation and maintaining homeostasis. Spaceflight-adaptation syndrome is the combination of space environmental conditions and the synergistic reaction of the human physiology. Our work addresses the role of oxidative stress and damage (OSaD) as a negative and contributing Risk Factor (RF) in the following areas of combined spaceflight related dysregulation: i) radiation induced cellular damage [1], [2] ii) immune impacts and the inflammatory response [3], [4] and iii) varicella zoster virus (VZV) reactivation [5]. Varicella-zoster (VZV)/Chicken Pox virus is a neurotropic human alphaherpes virus resulting in varicella upon primary infection, suppressed by the immune system becomes latent in ganglionic neurons, and reactivates under stress events to re-express in zoster and possibly shingles. Our laboratory has developed a complex three-dimensional (3D) normal human neural tissue model that emulates several characteristics of the human trigeminal ganglia (TG) and allows the study of combinatorial experimentation which addresses, simultaneously, OSaD associated with Spaceflight adaptation and habitation [6]. By combining the RFs of microgravity, radiation, and viral infection we will demonstrate that living in the space environment leads to significant physiological consequences for the peripheral and subsequently the central nervous system (PNS, CNS) associated with OSaD generation and consequentially endangers long-duration and exploration-class missions.

Developing an Advanced Life Support System for the Flexible Path into Deep Space

NASA Technical Reports Server (NTRS)

Jones, Harry W.; Kliss, Mark H.

2010-01-01

Long duration human missions beyond low Earth orbit, such as a permanent lunar base, an asteroid rendezvous, or exploring Mars, will use recycling life support systems to preclude supplying large amounts of metabolic consumables. The International Space Station (ISS) life support design provides a historic guiding basis for future systems, but both its system architecture and the subsystem technologies should be reconsidered. Different technologies for the functional subsystems have been investigated and some past alternates appear better for flexible path destinations beyond low Earth orbit. There is a need to develop more capable technologies that provide lower mass, increased closure, and higher reliability. A major objective of redesigning the life support system for the flexible path is achieving the maintainability and ultra-reliability necessary for deep space operations.

Radiation transport modeling and assessment to better predict radiation exposure, dose, and toxicological effects to human organs on long duration space flights.

PubMed

Denkins, P; Badhwar, G; Obot, V; Wilson, B; Jejelewo, O

2001-01-01

NASA is very interested in improving its ability to monitor and forecast the radiation levels that pose a health risk to space-walking astronauts as they construct the International Space Station and astronauts that will participate in long-term and deep-space missions. Human exploratory missions to the moon and Mars within the next quarter century, will expose crews to transient radiation from solar particle events which include high-energy galactic cosmic rays and high-energy protons. Because the radiation levels in space are high and solar activity is presently unpredictable, adequate shielding is needed to minimize the deleterious health effects of exposure to radiation. Today, numerous models have been developed and used to predict radiation exposure. Such a model is the Space Environment Information Systems (SPENVIS) modeling program, developed by the Belgian Institute for Space Aeronautics. SPENVIS, which has been assessed to be an excellent tool in characterizing the radiation environment for microelectronics and investigating orbital debris, is being evaluated for its usefulness with determining the dose and dose-equivalent for human exposure. Thus far. the calculations for dose-depth relations under varying shielding conditions have been in agreement with calculations done using HZETRN and PDOSE, which are well-known and widely used models for characterizing the environments for human exploratory missions. There is disagreement when assessing the impact of secondary radiation particles since SPENVIS does a crude estimation of the secondary radiation particles when calculating LET versus Flux. SPENVIS was used to model dose-depth relations for the blood-forming organs. Radiation sickness and cancer are life-threatening consequences resulting from radiation exposure. In space. exposure to radiation generally includes all of the critical organs. Biological and toxicological impacts have been included for discussion along with alternative risk mitigation methods--shielding and anti-carcinogens. c 2001. Elsevier Science Ltd. All rights reserved.

Radiation transport modeling and assessment to better predict radiation exposure, dose, and toxicological effects to human organs on long duration space flights

NASA Technical Reports Server (NTRS)

Denkins, P.; Badhwar, G.; Obot, V.; Wilson, B.; Jejelewo, O.

2001-01-01

NASA is very interested in improving its ability to monitor and forecast the radiation levels that pose a health risk to space-walking astronauts as they construct the International Space Station and astronauts that will participate in long-term and deep-space missions. Human exploratory missions to the moon and Mars within the next quarter century, will expose crews to transient radiation from solar particle events which include high-energy galactic cosmic rays and high-energy protons. Because the radiation levels in space are high and solar activity is presently unpredictable, adequate shielding is needed to minimize the deleterious health effects of exposure to radiation. Today, numerous models have been developed and used to predict radiation exposure. Such a model is the Space Environment Information Systems (SPENVIS) modeling program, developed by the Belgian Institute for Space Aeronautics. SPENVIS, which has been assessed to be an excellent tool in characterizing the radiation environment for microelectronics and investigating orbital debris, is being evaluated for its usefulness with determining the dose and dose-equivalent for human exposure. Thus far. the calculations for dose-depth relations under varying shielding conditions have been in agreement with calculations done using HZETRN and PDOSE, which are well-known and widely used models for characterizing the environments for human exploratory missions. There is disagreement when assessing the impact of secondary radiation particles since SPENVIS does a crude estimation of the secondary radiation particles when calculating LET versus Flux. SPENVIS was used to model dose-depth relations for the blood-forming organs. Radiation sickness and cancer are life-threatening consequences resulting from radiation exposure. In space. exposure to radiation generally includes all of the critical organs. Biological and toxicological impacts have been included for discussion along with alternative risk mitigation methods--shielding and anti-carcinogens. c 2001. Elsevier Science Ltd. All rights reserved.

Radiation transport modeling and assessment to better predict radiation exposure, dose, and toxicological effects to human organs on long duration space flights

NASA Astrophysics Data System (ADS)

Denkins, Pamela; Badhwar, Gautam; Obot, Victor; Wilson, Bobby; Jejelewo, Olufisayo

2001-08-01

NASA is very interested in improving its ability to monitor and forecast the radiation levels that pose a health risk to space-walking astronauts as they construct the International Space Station and astronauts that will participate in long-term and deep-space missions. Human exploratory missions to the moon and Mars within the next quarter century, will expose crews to transient radiation from solar particle events which include high-energy galactic cosmic rays and high-energy protons. Because the radiation levels in space are high and solar activity is presently unpredictable, adequate shielding is needed to minimize the deleterious health effects of exposure to radiation. Today, numerous models have been developed and used to predict radiation exposure. Such a model is the Space Environment Information Systems (SPENVIS) modeling program, developed by the Belgian Institute for Space Aeronautics. SPENVIS, which has been assessed to be an excellent tool in characterizing the radiation environment for microelectronics and investigating orbital debris, is being evaluated for its usefulness with determining the dose and dose-equivalent for human exposure. Thus far, the calculations for dose-depth relations under varying shielding conditions have been in agreement with calculations done using HZETRN and PDOSE, which are well-known and widely used models for characterizing the environments for human exploratory missions. There is disagreement when assessing the impact of secondary radiation particles since SPENVIS does a crude estimation of the secondary radiation particles when calculating LET versus Flux. SPENVIS was used to model dose-depth relations for the blood-forming organs. Radiation sickness and cancer are life-threatening consequences resulting from radiation exposure. In space, exposure to radiation generally includes all of the critical organs. Biological and toxicological impacts have been included for discussion along with alternative risk mitigation methods — shielding and anti-carcinogens.

NASA Advanced Explorations Systems: Advancements in Life Support Systems

NASA Technical Reports Server (NTRS)

Shull, Sarah A.; Schneider, Walter F.

2016-01-01

The NASA Advanced Exploration Systems (AES) Life Support Systems (LSS) project strives to develop reliable, energy-efficient, and low-mass spacecraft systems to provide environmental control and life support systems (ECLSS) critical to enabling long duration human missions beyond low Earth orbit (LEO). Highly reliable, closed-loop life support systems are among the capabilities required for the longer duration human space exploration missions assessed by NASA's Habitability Architecture Team (HAT). The LSS project is focused on four areas: architecture and systems engineering for life support systems, environmental monitoring, air revitalization, and wastewater processing and water management. Starting with the international space station (ISS) LSS systems as a point of departure (where applicable), the mission of the LSS project is three-fold: 1. Address discrete LSS technology gaps 2. Improve the reliability of LSS systems 3. Advance LSS systems towards integrated testing on the ISS. This paper summarized the work being done in the four areas listed above to meet these objectives. Details will be given on the following focus areas: Systems Engineering and Architecture- With so many complex systems comprising life support in space, it is important to understand the overall system requirements to define life support system architectures for different space mission classes, ensure that all the components integrate well together and verify that testing is as representative of destination environments as possible. Environmental Monitoring- In an enclosed spacecraft that is constantly operating complex machinery for its own basic functionality as well as science experiments and technology demonstrations, it's possible for the environment to become compromised. While current environmental monitors aboard the ISS will alert crew members and mission control if there is an emergency, long-duration environmental monitoring cannot be done in-orbit as current methodologies rely largely on sending environmental samples back to Earth. The LSS project is developing onboard analysis capabilities that will replace the need to return air and water samples from space for ground analysis. Air Revitalization- The air revitalization task is comprised of work in carbon dioxide removal, oxygen generation and recovery and trace contamination and particulate control. The CO2 Removal and associated air drying development efforts under the LSS project are focused both on improving the current SOA technology on the ISS and assessing and examining the viability of other sorbents and technologies available in academia and industry. The Oxygen Generation and Recovery technology development area encompasses several sub-tasks in an effort to supply O2 to the crew at the required conditions, to recover O2 from metabolic CO2, and to recycle recovered O2 back to the cabin environment. Current state-of-the-art oxygen generation systems aboard space station are capable of generating or recovering approximately 40% of required oxygen; for exploration missions this percentage needs to be greatly increased. A spacecraft cabin trace contaminant and particulate control system serves to keep the environment below the spacecraft maximum allowable concentration (SMAC) for chemicals and particulates. Both passive (filters) and active (scrubbers) methods contribute to the overall TC & PC design. Work in the area of trace contamination and particulate control under the LSS project is focused on making improvements to the SOA TC & PC systems on ISS to improve performance and reduce consumables. Wastewater Processing and Water Management- A major goal of the LSS project is the development of water recovery systems to support long duration human exploration beyond LEO. Current space station wastewater processing and water management systems distill urine and wastewater to recover water from urine and humidity condensate in the spacecraft at a approximately 74% recovery rate. For longer, farther missions into deep space, that recovery rate must be greatly increased so that astronauts can journey for months without resupply cargo ships from Earth.

NASA's extended duration orbiter medical program

NASA Technical Reports Server (NTRS)

Pool, Sam Lee; Sawin, Charles F.

1992-01-01

The physiological issues involved in safely extending Shuttle flights from 10 to 16 days have been viewed by some as academic. After all, they reasoned, humans already have lived and worked in space for periods exceeding even 28 days in the United States Skylab Program and onboard the Russian space stations. The difference in the Shuttle program is in the physical position of the astronauts as they reenter the Earth's atmosphere. Crewmembers in the earlier Apollo, Skylab, and Russian programs were returned to Earth in the supine position. Space Shuttle crewmembers, in contrast, are seated upright during reentry and landing; reexperiencing the Earth's g forces in this position has far more pronounced effects on the crewmember's physiological functions. The goal of the Extended Duration Orbiter (EDO) Medical Project (EDOMP) has been to ensure that crewmembers maintain physiological reserves sufficient to perform entry, landing, and egress safely. Early in the Shuttle Program, it became clear that physiological deconditioning during space flight could produce significant symptoms upon return to Earth. The signs and symptoms observed during the entry, landing, and egress after Shuttle missions have included very high heart rates and low blood pressures upon standing. Dizziness, 'graying out,' and fainting have occurred on ambulation or shortly thereafter. Other symptoms at landing have included headache, light-headedness, nausea and vomitting, leg cramping, inability to stand for several minutes after wheel-stop, and unsteadiness of gait.

The Importance of HRA in Human Space Flight: Understanding the Risks

NASA Technical Reports Server (NTRS)

Hamlin, Teri

2010-01-01

Human performance is critical to crew safety during space missions. Humans interact with hardware and software during ground processing, normal flight, and in response to events. Human interactions with hardware and software can cause Loss of Crew and/or Vehicle (LOCV) through improper actions, or may prevent LOCV through recovery and control actions. Humans have the ability to deal with complex situations and system interactions beyond the capability of machines. Human Reliability Analysis (HRA) is a method used to qualitatively and quantitatively assess the occurrence of human failures that affect availability and reliability of complex systems. Modeling human actions with their corresponding failure probabilities in a Probabilistic Risk Assessment (PRA) provides a more complete picture of system risks and risk contributions. A high-quality HRA can provide valuable information on potential areas for improvement, including training, procedures, human interfaces design, and the need for automation. Modeling human error has always been a challenge in part because performance data is not always readily available. For spaceflight, the challenge is amplified not only because of the small number of participants and limited amount of performance data available, but also due to the lack of definition of the unique factors influencing human performance in space. These factors, called performance shaping factors in HRA terminology, are used in HRA techniques to modify basic human error probabilities in order to capture the context of an analyzed task. Many of the human error modeling techniques were developed within the context of nuclear power plants and therefore the methodologies do not address spaceflight factors such as the effects of microgravity and longer duration missions. This presentation will describe the types of human error risks which have shown up as risk drivers in the Shuttle PRA which may be applicable to commercial space flight. As with other large PRAs of complex machines, human error in the Shuttle PRA proved to be an important contributor (12 percent) to LOCV. An existing HRA technique was adapted for use in the Shuttle PRA, but additional guidance and improvements are needed to make the HRA task in space-related PRAs easier and more accurate. Therefore, this presentation will also outline plans for expanding current HRA methodology to more explicitly cover spaceflight performance shaping factors.

Design and Parametric Sizing of Deep Space Habitats Supporting NASA'S Human Space Flight Architecture Team

NASA Technical Reports Server (NTRS)

Toups, Larry; Simon, Matthew; Smitherman, David; Spexarth, Gary

2012-01-01

NASA's Human Space Flight Architecture Team (HAT) is a multi-disciplinary, cross-agency study team that conducts strategic analysis of integrated development approaches for human and robotic space exploration architectures. During each analysis cycle, HAT iterates and refines the definition of design reference missions (DRMs), which inform the definition of a set of integrated capabilities required to explore multiple destinations. An important capability identified in this capability-driven approach is habitation, which is necessary for crewmembers to live and work effectively during long duration transits to and operations at exploration destinations beyond Low Earth Orbit (LEO). This capability is captured by an element referred to as the Deep Space Habitat (DSH), which provides all equipment and resources for the functions required to support crew safety, health, and work including: life support, food preparation, waste management, sleep quarters, and housekeeping.The purpose of this paper is to describe the design of the DSH capable of supporting crew during exploration missions. First, the paper describes the functionality required in a DSH to support the HAT defined exploration missions, the parameters affecting its design, and the assumptions used in the sizing of the habitat. Then, the process used for arriving at parametric sizing estimates to support additional HAT analyses is detailed. Finally, results from the HAT Cycle C DSH sizing are presented followed by a brief description of the remaining design trades and technological advancements necessary to enable the exploration habitation capability.

Screens as light biological variable in microgravitational space environment.

NASA Astrophysics Data System (ADS)

Schlacht, S.; Masali, M.

Foreword The ability of the biological organisms to orient themselves and to synchronize on the variations of the solar rhythms is a fundamental aspect in the planning of the human habitat above all when habitat is confined in the Space the planetary and in satellite outer space settlements In order to simulate the experience of the astronauts in long duration missions one of the dominant characteristics of the Space confined habitats is the absence of the earthlings solar cycles references The Sun is the main references and guidelines of the biological compass and timepiece The organism functions are influenced from the variation of the light in the round of the 24 hours the human circadian rhythms In these habitats it is therefore necessary to reproduce the color and intensity of the solar light variations along the arc of the day according to defined scientific programs assuring a better performance of the human organism subsubsection Multilayer Foldable Screens as biological environmental variable In the project Multilayer Foldable Screens are the monitors posed in the ceiling of an Outer Space habitat and are made of liquid crystals and covered with Kevlar they stand for a modulate and flexible structure for different arrangements and different visions Screens work sout s on all the solar light frequencies and display the images that the subject needs They are characterized from the emission of an environmental light that restores the earthly solar cycle for intensity and color temperature to irradiate

The Origin of the "Seasons" in Space Weather

NASA Astrophysics Data System (ADS)

Dikpati, Mausumi; Cally, Paul S.; McIntosh, Scott W.; Heifetz, Eyal

2017-11-01

Powerful `space weather' events caused by solar activity pose serious risks to human health, safety, economic activity and national security. Spikes in deaths due to heart attacks, strokes and other diseases occurred during prolonged power outages. Currently it is hard to prepare for and mitigate the impact of space weather because it is impossible to forecast the solar eruptions that can cause these terrestrial events until they are seen on the Sun. However, as recently reported in Nature, eruptive events like coronal mass ejections and solar flares, are organized into quasi-periodic "seasons", which include enhanced bursts of eruptions for several months, followed by quiet periods. We explored the dynamics of sunspot-producing magnetic fields and discovered for the first time that bursty and quiet seasons, manifested in surface magnetic structures, can be caused by quasi-periodic energy-exchange among magnetic fields, Rossby waves and differential rotation of the solar interior shear-layer (called tachocline). Our results for the first time provide a quantitative physical mechanism for forecasting the strength and duration of bursty seasons several months in advance, which can greatly enhance our ability to warn humans about dangerous solar bursts and prevent damage to satellites and power stations from space weather events.

The Origin of the "Seasons" in Space Weather.

PubMed

Dikpati, Mausumi; Cally, Paul S; McIntosh, Scott W; Heifetz, Eyal

2017-11-07

Powerful 'space weather' events caused by solar activity pose serious risks to human health, safety, economic activity and national security. Spikes in deaths due to heart attacks, strokes and other diseases occurred during prolonged power outages. Currently it is hard to prepare for and mitigate the impact of space weather because it is impossible to forecast the solar eruptions that can cause these terrestrial events until they are seen on the Sun. However, as recently reported in Nature, eruptive events like coronal mass ejections and solar flares, are organized into quasi-periodic "seasons", which include enhanced bursts of eruptions for several months, followed by quiet periods. We explored the dynamics of sunspot-producing magnetic fields and discovered for the first time that bursty and quiet seasons, manifested in surface magnetic structures, can be caused by quasi-periodic energy-exchange among magnetic fields, Rossby waves and differential rotation of the solar interior shear-layer (called tachocline). Our results for the first time provide a quantitative physical mechanism for forecasting the strength and duration of bursty seasons several months in advance, which can greatly enhance our ability to warn humans about dangerous solar bursts and prevent damage to satellites and power stations from space weather events.

International Space University variable gravity research facility design

NASA Astrophysics Data System (ADS)

Bailey, Sheila G.; Chiaramonte, Francis P.; Davidian, Kenneth J.

1994-03-01

A manned mission to Mars will require long travel times between Earth and Mars. However, exposure to long-duration zero gravity is known to be harmful to the human body. Some of the harmful effects are loss of heart and lung capacity, inability to stand upright, muscular weakness, and loss of bone calcium. A variable gravity research facility (VGRF) that will be placed in low Earth orbit (LEO) was designed by students of the International Space University 1989 Summer Session held in Strasbourg, France, to provide a testbed for conducting experiments in the life and physical sciences in preparation for a mission to Mars. This design exercise was unique because it addressed all aspects concerning a large space project. This report describes the VGRF design that was developed by international participants specializing in the following areas: the politics of international cooperation; engineering, architecture; in-space physiological, materials, and life science experimentation; data communications; and business and management.

The International Space University's variable gravity research facility design

NASA Astrophysics Data System (ADS)

Bailey, Sheila G.; Chiaramonte, Francis P.; Davidian, Kenneth J.

1991-09-01

A manned mission to Mars will require long travel times between Earth and Mars. However, exposure to long-duration zero gravity is known to be harmful to the human body. Some of the harmful effects are loss of heart and lung capacity, inability to stand upright, muscular weakness and loss of bone calcium. A variable gravity research facility (VGRF) that would be placed in low Earth orbit (LEO) was designed by students of the International Space University 1989 Summer Session held in Strasbourg, France, to provide a testbed for conducting experiments in the life and physical sciences in preparation for a mission to Mars. This design exercise was unique because it addressed all aspects concerning a large space project. The VGRF design was described which was developed by international participants specializing in the following areas: the politics of international cooperation, engineering, architecture, in-space physiology, material and life science experimentation, data communications, business, and management.

Discovering New Drugs on the Cellular Level

NASA Technical Reports Server (NTRS)

2005-01-01

With the Vision for Space Exploration calling for a sustained human presence in space, astronauts will need to grow plants, while in orbit, for nourishment that they will not receive from only consuming dehydrated foods. As a potential source of food for long-duration missions, space-grown plants could also give astronauts an important psychological boost, as fresh vegetables could serve as a welcomed change from monotonous meals consisting of reconstituted foods in plastic bags. Even more, these plants could likely aid in the recycling of air and wastewater on spacecraft. With a helping hand from a company by the name of Biolog, Inc., NASA is studying the impacts of decreased gravity and spaceborne bacteria on the plants being grown for food in space. With a helping hand from NASA, this very same company is creating powerful new cell- and bacteria-analysis tools for use in discovering and developing new drugs on Earth.

The International Space University's variable gravity research facility design

NASA Technical Reports Server (NTRS)

Bailey, Sheila G.; Chiaramonte, Francis P.; Davidian, Kenneth J.

1991-01-01

A manned mission to Mars will require long travel times between Earth and Mars. However, exposure to long-duration zero gravity is known to be harmful to the human body. Some of the harmful effects are loss of heart and lung capacity, inability to stand upright, muscular weakness and loss of bone calcium. A variable gravity research facility (VGRF) that would be placed in low Earth orbit (LEO) was designed by students of the International Space University 1989 Summer Session held in Strasbourg, France, to provide a testbed for conducting experiments in the life and physical sciences in preparation for a mission to Mars. This design exercise was unique because it addressed all aspects concerning a large space project. The VGRF design was described which was developed by international participants specializing in the following areas: the politics of international cooperation, engineering, architecture, in-space physiology, material and life science experimentation, data communications, business, and management.

Successful amplification of DNA aboard the International Space Station.

PubMed

Boguraev, Anna-Sophia; Christensen, Holly C; Bonneau, Ashley R; Pezza, John A; Nichols, Nicole M; Giraldez, Antonio J; Gray, Michelle M; Wagner, Brandon M; Aken, Jordan T; Foley, Kevin D; Copeland, D Scott; Kraves, Sebastian; Alvarez Saavedra, Ezequiel

2017-01-01

As the range and duration of human ventures into space increase, it becomes imperative that we understand the effects of the cosmic environment on astronaut health. Molecular technologies now widely used in research and medicine will need to become available in space to ensure appropriate care of astronauts. The polymerase chain reaction (PCR) is the gold standard for DNA analysis, yet its potential for use on-orbit remains under-explored. We describe DNA amplification aboard the International Space Station (ISS) through the use of a miniaturized miniPCR system. Target sequences in plasmid, zebrafish genomic DNA, and bisulfite-treated DNA were successfully amplified under a variety of conditions. Methylation-specific primers differentially amplified bisulfite-treated samples as would be expected under standard laboratory conditions. Our findings establish proof of concept for targeted detection of DNA sequences during spaceflight and lay a foundation for future uses ranging from environmental monitoring to on-orbit diagnostics.

Market Driven Space Exploration

NASA Astrophysics Data System (ADS)

Gavert, Raymond B.

2004-02-01

Market driven space exploration will have the opportunity to develop to new levels with the coming of space nuclear power and propulsion. NASA's recently established Prometheus program is expected to receive several billion dollars over the next five years for developing nuclear power and propulsion systems for future spacecraft. Not only is nuclear power and propulsion essential for long distance Jupiter type missions, but it also important for providing greater access to planets and bodies nearer to the Earth. NASA has been working with industrial partners since 1987 through its Research Partnerships Centers (RPCs) to utilize the attributes of space in Low Earth Orbit (LEO). Plans are now being made to utilize the RPCs and industrial partners in extending the duration and boundaries of human space flight to create new opportunities for exploration and discovery. Private investors are considering setting up shops in LEO for commercial purposes. The trend is for more industrial involvement in space. Nuclear power and propulsion will hasten the progress. The objective of this paper is to show the progression of space market driven research and its potential for supporting space exploration given nuclear power and propulsion capabilities.

Making media work in space: an interdisciplinary perspective on media and communication requirements for current and future space communities

NASA Astrophysics Data System (ADS)

Babidge, S.; Cokley, J.; Gordon, F.; Louw, E.

2005-10-01

As humans expand into space communities will form. These have already begun to form in small ways, such as long-duration missions on the International Space Station and the space shuttle, and small-scale tourist excursions into space. Social, behavioural and communications data emerging from such existing communities in space suggest that the physically-bounded, work-oriented and traditionally male-dominated nature of these extremely remote groups present specific problems for the resident astronauts, groups of them viewed as ‘communities’, and their associated groups who remain on Earth, including mission controllers, management and astronauts’ families. Notionally feminine group attributes such as adaptive competence, social adaptation skills and social sensitivity will be crucial to the viability of space communities and in the absence of gender equity, ‘staying in touch’ by means of ‘news from home’ becomes more important than ever. A template of news and media forms and technologies is suggested to service those needs and enhance the social viability of future terraforming activities.

Space transportation system options for extended duration and power

NASA Technical Reports Server (NTRS)

Loftus, J. P., Jr.

1979-01-01

A modification kit for the Space Transportation System (STS) Orbiter is proposed to provide more power and mission duration for payloads. The power extension package (PEP) - a flexible-substrate solar array deployed on the Space Shuttle Orbiter remote manipulator system - can provide as much as 29 kW total power for durations of 10 to 48 days. The kit is installed only for those flights which require enhanced power or duration. Modifications to the Orbiter thermal control and life support systems to improve heat balance and to reduce consumables are proposed. The changes consist of repositioning the Orbiter forward radiators and replacing the lithium hydroxide scrubber with a regenerable solid amine.

Deep Space Habitat Concept of Operations for Transit Mission Phases

NASA Technical Reports Server (NTRS)

Hoffman, Stephen J.

2011-01-01

The National Aeronautics and Space Administration (NASA) has begun evaluating various mission and system components of possible implementations of what the U.S. Human Spaceflight Plans Committee (also known as the Augustine Committee) has named the flexible path (Anon., 2009). As human spaceflight missions expand further into deep space, the duration of these missions increases to the point where a dedicated crew habitat element appears necessary. There are several destinations included in this flexible path a near Earth asteroid (NEA) mission, a Phobos/Deimos (Ph/D) mission, and a Mars surface exploration mission that all include at least a portion of the total mission in which the crew spends significant periods of time (measured in months) in the deep space environment and are thus candidates for a dedicated habitat element. As one facet of a number of studies being conducted by the Human Spaceflight Architecture Team (HAT) a workshop was conducted to consider how best to define and quantify habitable volume for these future deep space missions. One conclusion reached during this workshop was the need for a description of the scope and scale of these missions and the intended uses of a habitat element. A group was set up to prepare a concept of operations document to address this need. This document describes a concept of operations for a habitat element used for these deep space missions. Although it may eventually be determined that there is significant overlap with this concept of operations and that of a habitat destined for use on planetary surfaces, such as the Moon and Mars, no such presumption is made in this document.