DOE Office of Scientific and Technical Information (OSTI.GOV)

Coffrin, Carleton James; Hijazi, Hassan L; Van Hentenryck, Pascal R

Here this work revisits the Semidefine Programming (SDP) relaxation of the AC power flow equations in light of recent results illustrating the benefits of bounds propagation, valid inequalities, and the Convex Quadratic (QC) relaxation. By integrating all of these results into the SDP model a new hybrid relaxation is proposed, which combines the benefits from all of these recent works. This strengthened SDP formulation is evaluated on 71 AC Optimal Power Flow test cases from the NESTA archive and is shown to have an optimality gap of less than 1% on 63 cases. This new hybrid relaxation closes 50% ofmore » the open cases considered, leaving only 8 for future investigation.« less

Biopedagogies and Indigenous Knowledge: Examining Sport for Development and Peace for Urban Indigenous Young Women in Canada and Australia

ERIC Educational Resources Information Center

Hayhurst, Lyndsay M. C.; Giles, Audrey R.; Wright, Jan

2016-01-01

This paper uses transnational postcolonial feminist participatory action research (TPFPAR) to examine two sport for development and peace (SDP) initiatives that focus on Indigenous young women residing in urban areas, one in Vancouver, Canada, and one in Perth, Australia. We examine how SDP programs that target urban Indigenous young women and…

Model-based optimal design of experiments - semidefinite and nonlinear programming formulations

PubMed Central

Duarte, Belmiro P.M.; Wong, Weng Kee; Oliveira, Nuno M.C.

2015-01-01

We use mathematical programming tools, such as Semidefinite Programming (SDP) and Nonlinear Programming (NLP)-based formulations to find optimal designs for models used in chemistry and chemical engineering. In particular, we employ local design-based setups in linear models and a Bayesian setup in nonlinear models to find optimal designs. In the latter case, Gaussian Quadrature Formulas (GQFs) are used to evaluate the optimality criterion averaged over the prior distribution for the model parameters. Mathematical programming techniques are then applied to solve the optimization problems. Because such methods require the design space be discretized, we also evaluate the impact of the discretization scheme on the generated design. We demonstrate the techniques for finding D–, A– and E–optimal designs using design problems in biochemical engineering and show the method can also be directly applied to tackle additional issues, such as heteroscedasticity in the model. Our results show that the NLP formulation produces highly efficient D–optimal designs but is computationally less efficient than that required for the SDP formulation. The efficiencies of the generated designs from the two methods are generally very close and so we recommend the SDP formulation in practice. PMID:26949279

Model-based optimal design of experiments - semidefinite and nonlinear programming formulations.

PubMed

Duarte, Belmiro P M; Wong, Weng Kee; Oliveira, Nuno M C

2016-02-15

We use mathematical programming tools, such as Semidefinite Programming (SDP) and Nonlinear Programming (NLP)-based formulations to find optimal designs for models used in chemistry and chemical engineering. In particular, we employ local design-based setups in linear models and a Bayesian setup in nonlinear models to find optimal designs. In the latter case, Gaussian Quadrature Formulas (GQFs) are used to evaluate the optimality criterion averaged over the prior distribution for the model parameters. Mathematical programming techniques are then applied to solve the optimization problems. Because such methods require the design space be discretized, we also evaluate the impact of the discretization scheme on the generated design. We demonstrate the techniques for finding D -, A - and E -optimal designs using design problems in biochemical engineering and show the method can also be directly applied to tackle additional issues, such as heteroscedasticity in the model. Our results show that the NLP formulation produces highly efficient D -optimal designs but is computationally less efficient than that required for the SDP formulation. The efficiencies of the generated designs from the two methods are generally very close and so we recommend the SDP formulation in practice.

Regulation of Dynamical Systems to Optimal Solutions of Semidefinite Programs: Algorithms and Applications to AC Optimal Power Flow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dall'Anese, Emiliano; Dhople, Sairaj V.; Giannakis, Georgios B.

2015-07-01

This paper considers a collection of networked nonlinear dynamical systems, and addresses the synthesis of feedback controllers that seek optimal operating points corresponding to the solution of pertinent network-wide optimization problems. Particular emphasis is placed on the solution of semidefinite programs (SDPs). The design of the feedback controller is grounded on a dual e-subgradient approach, with the dual iterates utilized to dynamically update the dynamical-system reference signals. Global convergence is guaranteed for diminishing stepsize rules, even when the reference inputs are updated at a faster rate than the dynamical-system settling time. The application of the proposed framework to the controlmore » of power-electronic inverters in AC distribution systems is discussed. The objective is to bridge the time-scale separation between real-time inverter control and network-wide optimization. Optimization objectives assume the form of SDP relaxations of prototypical AC optimal power flow problems.« less

Optimal Power Flow in Multiphase Radial Networks with Delta Connections: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Changhong; Dall-Anese, Emiliano; Low, Steven H.

This paper focuses on multiphase radial distribution networks with mixed wye and delta connections, and proposes a semidefinite relaxation of the AC optimal power flow (OPF) problem. Two multiphase power-flow models are developed to facilitate the integration of delta-connected generation units/loads in the OPF problem. The first model extends traditional branch flow models - and it is referred to as extended branch flow model (EBFM). The second model leverages a linear relationship between per-phase power injections and delta connections, which holds under a balanced voltage approximation (BVA). Based on these models, pertinent OPF problems are formulated and relaxed to semidefinitemore » programs (SDPs). Numerical studies on IEEE test feeders show that SDP relaxations can be solved efficiently by a generic optimization solver. Numerical evidences indicate that solving the resultant SDP under BVA is faster than under EBFM. Moreover, both SDP solutions are numerically exact with respect to voltages and branch flows. It is also shown that the SDP solution under BVA has a small optimality gap, while the BVA model is accurate in the sense that it reflects actual system voltages.« less

A quasi-experimental study of maternal smoking during pregnancy and offspring academic achievement

PubMed Central

D'Onofrio, Brian M.; Singh, Amber L.; Iliadou, Anastasia; Lambe, Mats; Hultman, Christina M.; Neiderhiser, Jenae M.; Långström, Niklas; Lichtenstein, Paul

2013-01-01

Maternal smoking during pregnancy (SDP) is associated with lower academic achievement in offspring. The current study, which was based on all births in Sweden from 1983 through 1991, explored the possible causal processes underlying the association between SDP and offspring school grades and a standardized assessment of mathematic proficiency at age 15. The analyses compared relatives who varied in their exposure to SDP and who varied in their genetic relatedness. Although SDP was statistically associated with academic achievement when comparing unrelated individuals, the results suggest that SDP does not cause poorer academic performance, as full siblings differentially exposed to SDP did not differ in their academic scores. The pattern of results suggests that genetic factors shared by parents and their offspring explain significant variance in why offspring opposed to SDP have lower levels of academic achievement. Nevertheless, SDP impacts pregnancy-related outcomes. Reducing SDP, therefore, remains a major public health issue. PMID:20331655

Impact of an interactive video on decision making of patients with ischemic heart disease.

PubMed

Liao, L; Jollis, J G; DeLong, E R; Peterson, E D; Morris, K G; Mark, D B

1996-06-01

An experimental pilot study using repeated measures to examine the impact of an interactive video program on the decision making of patients with ischemic heart disease was carried on at a tertiary care center and a Veterans Affairs hospital. The patients (n = 80, mean age 61.1 years, 77% male, 75% white, 26.7% with acute myocardial infarction), who had undergone diagnostic cardiac catheterization and were found to have significant coronary artery disease (> or = 75% stenosis in at least one vessel), watched the Shared Decision-Making Program (SDP) for Ischemic Heart Disease (IHD), a novel interactive video system designed to provide information necessary for patients to participate actively in decision making. This program compares medical therapy, angioplasty, and bypass surgery through a physician narrator, patient testimonials, and empirically-based, patient-specific outcome estimates of short-time complications and long-term survival. Before and after viewing the SDP, patients completed surveys containing multiple choice questions and Likert scales. They rated the program as more helpful than all other decision aids except the physician, and after viewing the SDP they expressed increased confidence in their treatment choice and decreased confidence in alternative options (p = .0001). The greatest effects appeared to be concentrated in those patients with less education (p = .04), and the program appeared to increase anxiety in nonwhite patients compared with white patients (p = 0.07).

Maternal Smoking During Pregnancy and Offspring Birth Weight: A Genetically-Informed Approach Comparing Multiple Raters

PubMed Central

Knopik, Valerie S.; Marceau, Kristine; Palmer, Rohan H. C.; Smith, Taylor F.; Heath, Andrew C.

2016-01-01

Maternal smoking during pregnancy (SDP) is a significant public health concern with adverse consequences to the health and well-being of the fetus. There is considerable debate about the best method of assessing SDP, including birth/medical records, timeline follow-back approaches, multiple reporters, and biological verification (e.g., cotinine). This is particularly salient for genetically-informed approaches where it is not always possible or practical to do a prospective study starting during the prenatal period when concurrent biological specimen samples can be collected with ease. In a sample of families (N = 173) specifically selected for sibling pairs discordant for prenatal smoking exposure, we: (1) compare rates of agreement across different types of report—maternal report of SDP, paternal report of maternal SDP, and SDP contained on birth records from the Department of Vital Statistics; (2) examine whether SDP is predictive of birth weight outcomes using our best SDP report as identified via step (1); and (3) use a sibling-comparison approach that controls for genetic and familial influences that siblings share in order to assess the effects of SDP on birth weight. Results show high agreement between reporters and support the utility of retrospective report of SDP. Further, we replicate a causal association between SDP and birth weight, wherein SDP results in reduced birth weight even when accounting for genetic and familial confounding factors via a sibling comparison approach. PMID:26494459

Convex Relaxation of OPF in Multiphase Radial Networks with Wye and Delta Connections

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Changhong; Dall-Anese, Emiliano; Low, Steven

2017-08-01

This panel presentation focuses on multiphase radial distribution networks with wye and delta connections, and proposes a semidefinite relaxation of the AC optimal power flow (OPF) problem. Two multiphase power flow models are developed to facilitate the integration of delta-connected loads or generation resources in the OPF problem. The first model is referred to as the extended branch flow model (EBFM). The second model leverages a linear relationship between phase-to-ground power injections and delta connections that holds under a balanced voltage approximation (BVA). Based on these models, pertinent OPF problems are formulated and relaxed to semidefinite programs (SDPs). Numerical studiesmore » on IEEE test feeders show that the proposed SDP relaxations can be solved efficiently by a generic optimization solver. Numerical evidence also indicates that solving the resultant SDP under BVA is faster than under EBFM. Moreover, both SDP solutions are numerically exact with respect to voltages and branch flows. It is further shown that the SDP solution under BVA has a small optimality gap, and the BVA model is accurate in the sense that it reproduces actual system voltages.« less

Gene silencing of Sugar-dependent 1 (JcSDP1), encoding a patatin-domain triacylglycerol lipase, enhances seed oil accumulation in Jatropha curcas

PubMed Central

2014-01-01

Background Triacylglycerols (TAGs) are the most abundant form of storage oil in plants. They consist of three fatty acid chains (usually C16 or C18) covalently linked to glycerol. SDP1 is a specific lipase for the first step of TAG catabolism in Arabidopsis seeds. Arabidopsis mutants deficient in SDP1 accumulate high levels of oils, probably due to blockage in TAG degradation. We applied this knowledge from the model plant, Arabidopsis thaliana, to engineer increased seed oil content in the biodiesel plant Jatropha curcas using RNA interference (RNAi) technology. Results As Jatropha is a biodiesel crop, any significant increase in its seed oil content would be an important agronomic trait. Using A. thaliana as a model plant, we found that a deficiency of SDP1 led to higher TAG accumulation and a larger number of oil bodies in seeds compared with wild type (Columbia-0; Col-0). We cloned Jatropha JcSDP1, and verified its function by complementation of the Arabidopsis sdp1-5 mutant. Taking advantage of the observation with Arabidopsis, we used RNAi technology to generate JcSDP1 deficiency in transgenic Jatropha. We found that Jatropha JcSDP1-RNAi plants accumulated 13 to 30% higher total seed storage lipid, along with a 7% compensatory decrease in protein content, compared with control (CK; 35S:GFP) plants. Free fatty acid (FFA) content in seeds was reduced from 27% in control plants to 8.5% in JcSDP1-RNAi plants. Conclusion Here, we showed that SDP1 deficiency enhances seed oil accumulation in Arabidopsis. Based on this result, we generated SDP1-deficient transgenic Jatropha plants using by RNAi technology with a native JcSDP1 promoter to silence endogenous JcSDP1 expression. Seeds of Jatropha JcSDP1-RNAi plants accumulated up to 30% higher total lipid and had reduced FFA content compared with control (CK; 35S:GFP) plants. Our strategy of improving an important agronomic trait of Jatropha can be extended to other oil crops to yield higher seed oil. PMID:24606605

76 FR 37371 - Agency Information Collection: Comment Request for National Gap Analysis Program Evaluation

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-27

... Gap Analysis Program (GAP). The information collected will provide information for the Program's... DEPARTMENT OF THE INTERIOR U.S. Geological Survey [USGS--GX10RB0000SDP00] Agency Information Collection: Comment Request for National Gap Analysis Program Evaluation AGENCY: United States Geological...

Global solutions of restricted open-shell Hartree-Fock theory from semidefinite programming with applications to strongly correlated quantum systems.

PubMed

Veeraraghavan, Srikant; Mazziotti, David A

2014-03-28

We present a density matrix approach for computing global solutions of restricted open-shell Hartree-Fock theory, based on semidefinite programming (SDP), that gives upper and lower bounds on the Hartree-Fock energy of quantum systems. While wave function approaches to Hartree-Fock theory yield an upper bound to the Hartree-Fock energy, we derive a semidefinite relaxation of Hartree-Fock theory that yields a rigorous lower bound on the Hartree-Fock energy. We also develop an upper-bound algorithm in which Hartree-Fock theory is cast as a SDP with a nonconvex constraint on the rank of the matrix variable. Equality of the upper- and lower-bound energies guarantees that the computed solution is the globally optimal solution of Hartree-Fock theory. The work extends a previously presented method for closed-shell systems [S. Veeraraghavan and D. A. Mazziotti, Phys. Rev. A 89, 010502-R (2014)]. For strongly correlated systems the SDP approach provides an alternative to the locally optimized Hartree-Fock energies and densities with a certificate of global optimality. Applications are made to the potential energy curves of C2, CN, Cr2, and NO2.

Application of Semi-Definite Programming for Many-Fermion Systems

NASA Astrophysics Data System (ADS)

Zhao, Zhengji; Braams, Bastiaan; Fukuda, Mituhiro; Overton, Michael

2003-03-01

The ground state energy and other important observables of a many-fermion system with one- and two-body interactions only can all be obtained from the first order and second order Reduced Density Matrices (RDM's) of the system. Using these density matrices and a family of associated representability conditions one may obtain an approximation method for electronic structure theory that is in the mathematical form of Semi-Definite Programming (SDP): minimize a linear matrix functional over a space of positive semidefinite matrices subject to linear constraints. The representability conditions are some known necessary conditions, starting with the well-known P, Q, and G conditions [Claude Garrod and Jerome K. Percus, Reducation of the N-Particle Variational Problem, J. Math. Phys. 5 (1964) 1756-1776]. The RDM method with SDP has great potential advantages over the wave function method when the particle number N is large. The dimension of the full configuration space increases exponentially with N, but in RDM method with SDP the dimension of the objective matrix (which includes RDM's) increases only polynomially with N. We will report on the effect of adding the generalized three-index conditions proposed in [R. M. Erdahl, Representability, Int. J. Quantum Chem. 13 (1978) 697-718].

Documentation of and satisfaction with the service delivery process of electric powered scooters among adult users in different national contexts.

PubMed

Sund, Terje; Iwarsson, Susanne; Andersen, Mette C; Brandt, Åse

2013-03-01

The purpose of this study was to investigate how different service delivery systems for assistive devices were associated with the service delivery process (SDP) and user satisfaction in two national contexts when electric powered scooters were provided. The study had a follow-up design based on a consecutive inclusion of 50 Danish and 86 Norwegian adults as they were about to be provided a scooter. A study-specific structured questionnaire for documentation of the SDP was administered. The Satisfaction with Assistive Technology Services was used for documenting user satisfaction with the SDP. Besides descriptive statistics, regression analysis was used to identify contributors of variance and predictors of user satisfaction. The various steps of the SDP were carried out to a various degree. Significantly more total time was spent in the SDP in the Danish sample (p < 0.001). About 80% of the informants were satisfied/very satisfied with different aspects of the SDP. Time spent in the different steps was not associated with user satisfaction with the SDP. This study supports the assumption that structure of the service impacts on the SDP, but not that the process impacts on outcomes in terms of user satisfaction with the SDP. It may, however, be questioned whether this actually is an outcome.

Disentangling the relationships between maternal smoking during pregnancy and co-occurring risk factors

PubMed Central

Ellingson, Jarrod M.; Rickert, Martin E.; Lichtenstein, Paul; Långström, Niklas; D’Onofrio, Brian M.

2013-01-01

Background Maternal smoking during pregnancy (SDP) has been extensively studied as a risk factor for adverse offspring outcomes and is known to co-occur with other familial risk factors. Accounting for general familial risk factors has attenuated associations between SDP and adverse offspring outcomes, and identifying these confounds will be critical to elucidating the relationship between SDP and its psychological correlates. Methods The current study aimed to disentangle the relationship between maternal SDP and co-occurring risk factors (maternal criminal activity, drug problems, teen pregnancy, educational attainment, and cohabitation at childbirth) using a population-based sample of full- (n=206,313) and half-sister pairs (n=19,363) from Sweden. Logistic regression models estimated the strength of association between SDP and co-occurring risk factors. Bivariate behavioral genetic models estimated the degree to which associations between SDP and co-occurring risk factors are attributable to genetic and environmental factors. Results Maternal SDP was associated with an increase in all co-occurring risk factors. Of the variance associated with SDP, 45% was attributed to genetic factors and 53% was attributed to unshared environmental factors. In bivariate models, genetic factors accounted for 21% (non- drug-, non-violence-related crimes) to 35% (drug-related crimes) of the covariance between SDP and co-occurring risk factors. Unshared environmental factors accounted for the remaining covariance. Conclusions The genetic factors that influence a woman’s criminal behavior, substance abuse, and her offspring’s rearing environment also influence SDP. Therefore, the intergenerational transmission of genes conferring risk for antisocial behavior and substance misuse may influence the associations between maternal SDP and adverse offspring outcomes. PMID:22115276

Bounding the Set of Classical Correlations of a Many-Body System

NASA Astrophysics Data System (ADS)

Fadel, Matteo; Tura, Jordi

2017-12-01

We present a method to certify the presence of Bell correlations in experimentally observed statistics, and to obtain new Bell inequalities. Our approach is based on relaxing the conditions defining the set of correlations obeying a local hidden variable model, yielding a convergent hierarchy of semidefinite programs (SDP's). Because the size of these SDP's is independent of the number of parties involved, this technique allows us to characterize correlations in many-body systems. As an example, we illustrate our method with the experimental data presented in Science 352, 441 (2016), 10.1126/science.aad8665.

Solar concentrator technology development for space based applications, volume 1

NASA Technical Reports Server (NTRS)

Pintz, A.; Castle, C. H.; Reimer, R. R.

1992-01-01

Thermoelectric conversion using a radio-isotope heat source has been used where outer planetary space craft are too far away for absorbing significant solar energy. Solar dynamic power (SDP) conversion is one technology that offers advantages for applications within the inner planet region. Since SDP conversion efficiency can be 2 to 3 times higher than photovoltaic, the collecting surfaces are much reduced in area and therefore lighter. This becomes an advantage in allocating more weight to launched payloads. A second advantage results for low earth orbit applications. The reduced area results in lower drag forces on the spacecraft and requires less reboost propellant to maintain orbit. A third advantage occurs because of the sun-to-shade cycling while in earth orbit. Photovoltaic systems require batteries to store energy for use when in the shade, and battery life for periods of 10 to 15 years is not presently achievable. For these reasons the Solar Dynamics and Thermal Systems Branch at NASA LeRC has funded work in developing SDP systems. The generic SDP system uses a large parabolic solar concentrator to focus solar energy onto a power conversion device. The concentrators are large areas and must therefore be efficient and have low specific weights. Yet these surfaces must be precise and capable of being stowed in a launch vehicle and then deployed and sometimes unfurled in space. There are significant technical challenges in engineering such structures, and considerable investigation has been made to date. This is the first of two volumes reporting on the research done by the Advanced Manufacturing Center at Cleveland State University to assist NASA LeRC in evaluating this technology. The objective of the grant was to restore the solar concentrator development technology of the 1960s while improving it with advances that have occurred since then. This report summarizes the work done from January 1989 through December 1991.

Solar concentrator technology development for space based applications, volume 2

NASA Technical Reports Server (NTRS)

Pintz, A.; Castle, C. H.; Reimer, R. R.

1992-01-01

Thermoelectric conversion using a radio-isotope heat source has been used where outer planetary space craft are too far away for absorbing significant solar energy. Solar dynamic power (SDP) conversion is one technology that offers advantages for applications within the inner planet region. Since SDP conversion efficiency can be 2 to 3 times higher than photovoltaic, the collecting surfaces are much reduced in area and therefore lighter. This becomes an advantage in allocating more weight to launched payloads. A second advantage results for low earth orbit applications. The reduced area results in lower drag forces on the spacecraft and requires less reboost propellant to maintain orbit. A third advantage occurs because of the sun-to-shade cycling while in earth orbit. Photovoltaic systems require batteries to store energy for use when in the shade, and battery life for periods of 10 to 15 years is not presently achievable. For these reasons the Solar Dynamics and Thermal Systems Branch at NASA LeRC has funded work in developing SDP systems. The generic SDP system uses a large parabolic solar concentrator to focus solar energy onto a power conversion device. The concentrators are large areas and must therefore be efficient and have low specific weights. Yet these surfaces must be precise and capable of being stowed in a launch vehicle and then deployed and sometimes unfurled in space. There are significant technical challenges in engineering such structures, and considerable investigation has been made to date. This is the second of two volumes reporting on the research done by the Advanced Manufacturing Center at Cleveland State University to assist NASA LeRC in evaluating this technology. This volume includes the appendices of selected data sets, drawings, and procedures. The objective of the grant was to restore the solar concentrator development technology of the 1960s while improving it with advances that have occurred since then. This report summarizes the work done from January 1989 through December 1991.

Soil degradation level under particular annual rainfall at Jenawi District– Karanganyar, Indonesia

NASA Astrophysics Data System (ADS)

Herawati, A.; Suntoro; Widijanto, H.; Pusponegoro, I.; Sutopo, N. R.; Mujiyo

2018-03-01

The study of the climatic elements such as rainfall is vital for the sustainable development of agriculture at a region. The aims of the study were to evaluate the soil degradation based on the annual rainfall and to determine the key factors which responsible for the soil degradation at in Jenawi Sub-District. The mapping of soil degradation potency is an identification of initial soil condition to discover the potential of the land degradation. The mapping was done by overlaying the map of soil, slope, rainfall and land use with the standard procedures to obtain the value and status of Soil Degradation Potency (SDP). The result showed that SDP in Jenawi District categorized in very low (SDP I) 0.00 ha (0.00%); low (SDP II) 109.01 ha (2.57%); moderate (SDP III) 1,935.92 ha (45.63%); high (SDP IV) 1,959.54 ha (46.19%) and very high (SDP V) 238.08 ha (5.61%). The rainfall is the factor which has the strong correlation with the SDP (r = 0.65, P < 0.01, n = 306). The changes in the rainfall as the impact of climate change need to be anticipated to minimize soil degradation. The result can be adapted to the rainfall changes in various ways based on local soil-land characteristics.

The Classification of Sini Decoction Pattern in Traditional Chinese Medicine by Gene Expression Profiling

PubMed Central

Cheng, Hung-Tsu; Chen, Chaang-Ray; Li, Chia-Yang; Huang, Chao-Ying

2016-01-01

We investigated the syndromes of the Sini decoction pattern (SDP), a common ZHENG in traditional Chinese medicine (TCM). The syndromes of SDP were correlated with various severe Yang deficiency related symptoms. To obtain a common profile for SDP, we distributed questionnaires to 300 senior clinical TCM practitioners. According to the survey, we concluded 2 sets of symptoms for SDP: (1) pulse feels deep or faint and (2) reversal cold of the extremities. Twenty-four individuals from Taipei City Hospital, Linsen Chinese Medicine Branch, Taiwan, were recruited. We extracted the total mRNA of peripheral blood mononuclear cells from the 24 individuals for microarray experiments. Twelve individuals (including 6 SDP patients and 6 non-SDP individuals) were used as the training set to identify biomarkers for distinguishing the SDP and non-SDP groups. The remaining 12 individuals were used as the test set. The test results indicated that the gene expression profiles of the identified biomarkers could effectively distinguish the 2 groups by adopting a hierarchical clustering algorithm. Our results suggest the feasibility of using the identified biomarkers in facilitating the diagnosis of TCM ZHENGs. Furthermore, the gene expression profiles of biomarker genes could provide a molecular explanation corresponding to the ZHENG of TCM. PMID:27200105

Growth response of broilers to spray-dried plasma in pelleted or expanded feed processed at high temperature.

PubMed

Campbell, J M; Russell, L E; Crenshaw, J D; Behnke, K C; Clark, P M

2006-09-01

A series of 4 experiments evaluated effects of mash conditioning temperature from a pellet mill or expander on performance of broilers fed pelleted diets containing spray-dried plasma (SDP). All experiments utilized Ross x Ross 308 male broilers randomly assigned to their respective treatments (6 or 10 broilers/pen and 8 or 10 pens/treatment). Treatments in Exp. 1 consisted of a control (0% SDP), SDP coated postpelleting, or SDP blended into the meal prepelleting. Experiment 2 and 3 included the same 3 treatments as in Exp. 1 but with additional treatments of SDP blended into the meal and conditioned at 90 or 95 degrees C before pelleting. In Exp. 4, treatments consisted of a control (0% SDP) or SDP blended into the meal and pelleted (85 degrees C conditioning temperature) or expanded (149 degrees C final effective temperature) and then pelleted. Corn-soybean meal-based diets were formulated to be equal in lysine and ME in all experiments. Pelleted diets were conditioned for 15 s at 85 degrees C, and expanded diets were conditioned at 95 degrees C, 29.7 MJ/t, 13.95 kg/cm2 cone pressure, exit temperature of 149 degrees C, and then pelleted through a 4 x 32-mm die. In Exp. 1, ADG and feed intake were improved (P < 0.05) for broilers fed SDP from d 1 to 28 of age, with greater BW at d 42. In Exp. 2, both in early (d 1 to 28 of age) phases, and overall (d 1 to 42 of age), broilers fed SDP had improved (P < 0.05) gain and efficiency. In Exp. 3, ADG, feed intake, efficiency of gain, and BW were improved (P < 0.01) for broilers fed SDP from d 1 to 21 of age, regardless of conditioning temperature. In Exp. 4, broilers fed SDP had improved (P < 0.05) gain, BW, and feed intake regardless of processing method. Overall, the results of all of the experiments demonstrated that pellet conditioning temperature from 85 to 95 degrees C and expander temperatures to 149 degrees C did not impair the positive growth effects of SDP in pelleted or expanded broiler feed.

Defense Against Cannibalism: The SdpI Family of Bacterial Immunity/Signal Transduction Proteins

PubMed Central

Povolotsky, Tatyana Leonidovna; Orlova, Ekaterina; Tamang, Dorjee G.

2010-01-01

The SdpI family consists of putative bacterial toxin immunity and signal transduction proteins. One member of the family in Bacillus subtilis, SdpI, provides immunity to cells from cannibalism in times of nutrient limitation. SdpI family members are transmembrane proteins with 3, 4, 5, 6, 7, 8, or 12 putative transmembrane α-helical segments (TMSs). These varied topologies appear to be genuine rather than artifacts due to sequencing or annotation errors. The basic and most frequently occurring element of the SdpI family has 6 TMSs. Homologues of all topological types were aligned to determine the homologous TMSs and loop regions, and the positive-inside rule was used to determine sidedness. The two most conserved motifs were identified between TMSs 1 and 2 and TMSs 4 and 5 of the 6 TMS proteins. These showed significant sequence similarity, leading us to suggest that the primordial precursor of these proteins was a 3 TMS–encoding genetic element that underwent intragenic duplication. Various deletional and fusional events, as well as intragenic duplications and inversions, may have yielded SdpI homologues with topologies of varying numbers and positions of TMSs. We propose a specific evolutionary pathway that could have given rise to these distantly related bacterial immunity proteins. We further show that genes encoding SdpI homologues often appear in operons with genes for homologues of SdpR, SdpI’s autorepressor. Our analyses allow us to propose structure–function relationships that may be applicable to most family members. Electronic supplementary material The online version of this article (doi:10.1007/s00232-010-9260-7) contains supplementary material, which is available to authorized users. PMID:20563570

Early-life dietary spray-dried plasma influences immunological and intestinal injury responses to later-life Salmonella typhimurium challenge.

PubMed

Boyer, P E; D'Costa, S; Edwards, L L; Milloway, M; Susick, E; Borst, L B; Thakur, S; Campbell, J M; Crenshaw, J D; Polo, J; Moeser, A J

2015-03-14

Increasing evidence supports the concept that early-life environmental influences, including nutrition and stress, have an impact on long-term health outcomes and disease susceptibility. The objective of the present study was to determine whether dietary spray-dried plasma (SDP), fed during the first 2 weeks post-weaning (PW), influences subsequent immunological and intestinal injury responses to Salmonella typhimurium challenge. A total of thirty-two piglets (age 16-17 d) were weaned onto nursery diets containing 0, 2·5 % SDP (fed for 7 d PW) or 5 % SDP (fed for 14 d PW), and were then fed control diets (without SDP), for the remainder of the experiment. At 34 d PW (age 50 d), pigs were challenged with 3 × 10⁹ colony-forming units of S. typhimurium. A control group (non-challenged) that was fed 0 % SDP in the nursery was included. At 2 d post-challenge, the distal ileum was harvested for the measurement of inflammatory, histological and intestinal physiological parameters. S. typhimurium challenge induced elevated ileal histological scores, myeloperoxidase (MPO), IL-8 and TNF, and increased intestinal permeability (indicated by reduced transepithelial voltage (potential difference) and elevated 4 kDa fluorescein isothiocyanate dextran (FD4) flux rates). Compared with S. typhimurium-challenged controls (0 % SDP), pigs fed the 5 % SDP-14 d diet exhibited reduced ileal histological scores, MPO levels, IL-8 levels and FD4 flux rates. Pigs fed the 5 % SDP-14 d nursery diet exhibited increased levels of plasma and ileal TNF-α in response to the challenge, compared with the other treatments. These results indicate that inclusion of SDP in PW diets can have an influence on subsequent immunological and intestinal injury responses induced by later-life S. typhimurium challenge.

Children of people with somatization disorder.

PubMed

Livingston, R

1993-05-01

The author investigated psychopathology, suicidal behavior, child abuse, somatization, and health care utilization in 34 children with a parent who has somatization disorder (SD-P) and two comparison groups: 41 children with a somatizing parent (SOM) (fewer symptoms than required for diagnosis of SD-P), and 30 pediatrically ill controls (CON). Child and parent versions of the Diagnostic Interview for Children and Adolescents were scored for diagnosis and symptom counts in specified categories. Medical records were obtained and abstracted. Children of SD-P had significantly more psychiatric disorders and suicide attempts than did children of SOM or the CON. SD-P and CON had significantly more unexplained physical symptoms than SOM. SD-P showed a trend toward more hospitalizations and experienced significantly more maltreatment. Children of SD-P are at significant risk in several respects. Clinical implications of these findings include a need for awareness and cooperation among general psychiatrists, primary care physicians, and child and adolescent psychiatrists to facilitate detection and treatment of these children's problems.

The Anti-Inflammatory Effect of Spray-Dried Plasma Is Mediated by a Reduction in Mucosal Lymphocyte Activation and Infiltration in a Mouse Model of Intestinal Inflammation.

PubMed

Pérez-Bosque, Anna; Miró, Lluïsa; Amat, Concepció; Polo, Javier; Moretó, Miquel

2016-10-22

Spray-dried preparations from porcine and bovine plasma can alleviate mucosal inflammation in experimental models and improve symptoms in patients with enteropathy. In rodents, dietary supplementation with porcine spray-dried plasma (SDP) attenuates intestinal inflammation and improves the epithelial barrier function during intestinal inflammation induced by Staphylococcus aureus enterotoxin B (SEB). The aim of this study was to discern the molecular mechanisms involved in the anti-inflammatory effects of SDP. Male C57BL/6 mice were fed with 8% SDP or control diet (based on milk proteins) for two weeks, from weaning until day 33. On day 32, the mice were given a SEB dose (i.p., 25 µg/mouse) or vehicle. SEB administration increased cell recruitment to mesenteric lymph nodes and the percentage of activated Th lymphocytes and SDP prevented these effects). SDP supplementation increased the expression of interleukin 10 (IL-10) or transforming growth factor- β (TGF-β) compared to the SEB group. The SEB challenge increased six-fold the expression of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) and intercellular adhesion molecule 1 (ICAM-1); and these effects were attenuated by SDP supplementation. SEB also augmented NF-κB phosphorylation, an effect that was prevented by dietary SDP. Our results indicate that the anti-inflammatory effects of SDP involve the regulation of transcription factors and adhesion molecules that reduce intestinal cell infiltration and the degree of the inflammatory response.

Prenatal Exposure Effects on Early Adolescent Substance Use: Preliminary Evidence From a Genetically Informed Bayesian Approach.

PubMed

Bidwell, L Cinnamon; Marceau, Kristine; Brick, Leslie A; Karoly, Hollis C; Todorov, Alexandre A; Palmer, Rohan H; Heath, Andrew C; Knopik, Valerie S

2017-09-01

Given the controversy surrounding the question of whether there are direct or causal effects of exposure to maternal smoking during pregnancy (SDP) on offspring outcomes such as substance use during the adolescent years, we sought to test, on a preliminary basis, within- and between-family associations of SDP and initiation of substance use early in adolescence (by age 15 years) using a discordant sibling design. We used a sibling-comparison approach in a sample of 173 families drawn from the state of Missouri, wherein mothers were discordant for smoking behaviors between two different pregnancies, to test for associations of SDP and initiation of substance use in a younger adolescent cohort. The discordant sibling comparison approach allows for disentangling familial effects from direct effects of SDP through the purposeful collection of data from siblings within the same family with differential exposure. There were no between- or within-family effects of SDP on initiation of any type of substance use (alcohol, marijuana, smoking, and other drug classes), suggesting that SDP does not exert a direct effect on substance use in early adolescence. Preliminary findings did not support an association of SDP and initiation of substance use in this younger adolescent sample. Studies such as this one can help build a body of evidence to explain whether associations of SDP and adolescent outcomes reflect a direct effect of SPD or may instead be attributable to familial confounders that are controlled in the discordant sibling design.

Treatment with solubilized Silk-Derived Protein (SDP) enhances rabbit corneal epithelial wound healing.

PubMed

Abdel-Naby, Waleed; Cole, Brigette; Liu, Aihong; Liu, Jingbo; Wan, Pengxia; Schreiner, Ryan; Infanger, David W; Paulson, Nicholas B; Lawrence, Brian D; Rosenblatt, Mark I

2017-01-01

There is a significant clinical need to improve current therapeutic approaches to treat ocular surface injuries and disease, which affect hundreds of millions of people annually worldwide. The work presented here demonstrates that the presence of Silk-Derived Protein (SDP) on the healing rabbit corneal surface, administered in an eye drop formulation, corresponds with an enhanced epithelial wound healing profile. Rabbit corneas were denuded of their epithelial surface, and then treated for 72-hours with either PBS or PBS containing 5 or 20 mg/mL SDP in solution four times per day. Post-injury treatment with SDP formulations was found to accelerate the acute healing phase of the injured rabbit corneal epithelium. In addition, the use of SDP corresponded with an enhanced tissue healing profile through the formation of a multi-layered epithelial surface with increased tight junction formation. Additional biological effects were also revealed that included increased epithelial proliferation, and increased focal adhesion formation with a corresponding reduction in the presence of MMP-9 enzyme. These in vivo findings demonstrate for the first time that the presence of SDP on the injured ocular surface may aid to improve various steps of rabbit corneal wound healing, and provides evidence that SDP may have applicability as an ingredient in therapeutic ophthalmic formulations.

Optimizing Wellfield Operation in a Variable Power Price Regime.

PubMed

Bauer-Gottwein, Peter; Schneider, Raphael; Davidsen, Claus

2016-01-01

Wellfield management is a multiobjective optimization problem. One important objective has been energy efficiency in terms of minimizing the energy footprint (EFP) of delivered water (MWh/m(3) ). However, power systems in most countries are moving in the direction of deregulated markets and price variability is increasing in many markets because of increased penetration of intermittent renewable power sources. In this context the relevant management objective becomes minimizing the cost of electric energy used for pumping and distribution of groundwater from wells rather than minimizing energy use itself. We estimated EFP of pumped water as a function of wellfield pumping rate (EFP-Q relationship) for a wellfield in Denmark using a coupled well and pipe network model. This EFP-Q relationship was subsequently used in a Stochastic Dynamic Programming (SDP) framework to minimize total cost of operating the combined wellfield-storage-demand system over the course of a 2-year planning period based on a time series of observed price on the Danish power market and a deterministic, time-varying hourly water demand. In the SDP setup, hourly pumping rates are the decision variables. Constraints include storage capacity and hourly water demand fulfilment. The SDP was solved for a baseline situation and for five scenario runs representing different EFP-Q relationships and different maximum wellfield pumping rates. Savings were quantified as differences in total cost between the scenario and a constant-rate pumping benchmark. Minor savings up to 10% were found in the baseline scenario, while the scenario with constant EFP and unlimited pumping rate resulted in savings up to 40%. Key factors determining potential cost savings obtained by flexible wellfield operation under a variable power price regime are the shape of the EFP-Q relationship, the maximum feasible pumping rate and the capacity of available storage facilities. © 2015 The Authors. Groundwater published by Wiley Periodicals, Inc. on behalf of National Ground Water Association.

Identification of Sleep-Modulated Pathways Involved in Neuroprotection from Stroke.

PubMed

Pace, Marta; Baracchi, Francesca; Gao, Bo; Bassetti, Claudio

2015-11-01

Sleep deprivation (SDp) performed before stroke induces an ischemic tolerance state as observed in other forms of preconditioning. As the mechanisms underlying this effect are not well understood, we used DNA oligonucleotide microarray analysis to identify the genes and the gene-pathways underlying SDp preconditioning effects. Gene expression was analyzed 3 days after stroke in 4 experimental groups: (i) SDp performed before focal cerebral ischemia (IS) induction; (ii) SDp performed before sham surgery; (iii) IS without SDp; and (iv) sham surgery without SDp. SDp was performed by gentle handling during the last 6 h of the light period, and ischemia was induced immediately after. Basic sleep research laboratory. Stroke induced a massive alteration in gene expression both in sleep deprived and non-sleep deprived animals. However, compared to animals that underwent ischemia alone, SDp induced a general reduction in transcriptional changes with a reduction in the upregulation of genes involved in cell cycle regulation and immune response. Moreover, an upregulation of a new neuroendocrine pathway which included melanin concentrating hormone, glycoprotein hormones-α-polypeptide and hypocretin was observed exclusively in rats sleep deprived before stroke. Our data indicate that sleep deprivation before stroke reprogrammed the signaling response to injury. The inhibition of cell cycle regulation and inflammation are neuroprotective mechanisms reported also for other forms of preconditioning treatment, whereas the implication of the neuroendocrine function is novel and has never been described before. These results therefore provide new insights into neuroprotective mechanisms involved in ischemic tolerance mechanisms. © 2015 Associated Professional Sleep Societies, LLC.

Tests of the Amtrak SDP-40F Train Consist Conducted on Chessie System Track

DOT National Transportation Integrated Search

1979-05-01

This report describes tests of an SDP-40F train consist conducted on Chessie System track during June 1977. The tests consisted of the operation of two typical AMTRAK passenger consists, one powered by two SDP-40F's and the other by two E-8's, over a...

What is the Effect of Interannual Hydroclimatic Variability on Water Supply Reservoir Operations?

NASA Astrophysics Data System (ADS)

Galelli, S.; Turner, S. W. D.

2015-12-01

Rather than deriving from a single distribution and uniform persistence structure, hydroclimatic data exhibit significant trends and shifts in their mean, variance, and lagged correlation through time. Consequentially, observed and reconstructed streamflow records are often characterized by features of interannual variability, including long-term persistence and prolonged droughts. This study examines the effect of these features on the operating performance of water supply reservoirs. We develop a Stochastic Dynamic Programming (SDP) model that can incorporate a regime-shifting climate variable. We then compare the performance of operating policies—designed with and without climate variable—to quantify the contribution of interannual variability to standard policy sub-optimality. The approach uses a discrete-time Markov chain to partition the reservoir inflow time series into small number of 'hidden' climate states. Each state defines a distinct set of inflow transition probability matrices, which are used by the SDP model to condition the release decisions on the reservoir storage, current-period inflow and hidden climate state. The experimental analysis is carried out on 99 hypothetical water supply reservoirs fed from pristine catchments in Australia—all impacted by the Millennium drought. Results show that interannual hydroclimatic variability is a major cause of sub-optimal hedging decisions. The practical import is that conventional optimization methods may misguide operators, particularly in regions susceptible to multi-year droughts.

Heuristic reusable dynamic programming: efficient updates of local sequence alignment.

PubMed

Hong, Changjin; Tewfik, Ahmed H

2009-01-01

Recomputation of the previously evaluated similarity results between biological sequences becomes inevitable when researchers realize errors in their sequenced data or when the researchers have to compare nearly similar sequences, e.g., in a family of proteins. We present an efficient scheme for updating local sequence alignments with an affine gap model. In principle, using the previous matching result between two amino acid sequences, we perform a forward-backward alignment to generate heuristic searching bands which are bounded by a set of suboptimal paths. Given a correctly updated sequence, we initially predict a new score of the alignment path for each contour to select the best candidates among them. Then, we run the Smith-Waterman algorithm in this confined space. Furthermore, our heuristic alignment for an updated sequence shows that it can be further accelerated by using reusable dynamic programming (rDP), our prior work. In this study, we successfully validate "relative node tolerance bound" (RNTB) in the pruned searching space. Furthermore, we improve the computational performance by quantifying the successful RNTB tolerance probability and switch to rDP on perturbation-resilient columns only. In our searching space derived by a threshold value of 90 percent of the optimal alignment score, we find that 98.3 percent of contours contain correctly updated paths. We also find that our method consumes only 25.36 percent of the runtime cost of sparse dynamic programming (sDP) method, and to only 2.55 percent of that of a normal dynamic programming with the Smith-Waterman algorithm.

The Association between Self-Defeating Personality Characteristics, Career Indecision, and Vocational Identity.

ERIC Educational Resources Information Center

Sweeney, Marie L.; Schill, Thomas R.

1998-01-01

Of 81 men and 69 women studied, those with more self-defeating personality (SDP) characteristics were more career indecisive and had less vocational identity. Women with more SDP had significantly greater career choice anxiety than similar men. Depression contributed to indecision and lack of vocational identity for SDP men and to lack of…

Optimal design of FIR triplet halfband filter bank and application in image coding.

PubMed

Kha, H H; Tuan, H D; Nguyen, T Q

2011-02-01

This correspondence proposes an efficient semidefinite programming (SDP) method for the design of a class of linear phase finite impulse response triplet halfband filter banks whose filters have optimal frequency selectivity for a prescribed regularity order. The design problem is formulated as the minimization of the least square error subject to peak error constraints and regularity constraints. By using the linear matrix inequality characterization of the trigonometric semi-infinite constraints, it can then be exactly cast as a SDP problem with a small number of variables and, hence, can be solved efficiently. Several design examples of the triplet halfband filter bank are provided for illustration and comparison with previous works. Finally, the image coding performance of the filter bank is presented.

Exposure-related effects of formulated Pseudomonas fluorescens strain CL145A to glochidia from seven unionid mussel species

USGS Publications Warehouse

Luoma, James A.; Weber, Kerry L.; Severson, Todd J.; Schreier, Theresa M.; Mayer, Denise A.; Aloisi, Douglas B.; Eckert, Nathan L.

2015-01-01

Glochidia viability was reduced in two of the six species exposed to 50 mg/L SDP and in four of the six species exposed to 100 mg/L SDP when compared to untreated control groups at 6, 12, and 24 hours. Regardless of sample time, concentrations of 200 and 300 mg/L of SDP and 300 mg/L of heat-deactivated SDP (positive control) substantially reduced glochidia viability in all species except, L. higginsii. Glochidia viability was only reduced for L. cardium exposed to FDP at concentrations ≥ 200 mg/L. After 24 hours of FDP exposure, differences in glochidia viability were only detected in M. nervosa that were exposed to 300 mg/L of heat-deactivated SDP. However, given the low viability in the control group, the results for M. nervosa should be interpreted with caution.

Efficient dual approach to distance metric learning.

PubMed

Shen, Chunhua; Kim, Junae; Liu, Fayao; Wang, Lei; van den Hengel, Anton

2014-02-01

Distance metric learning is of fundamental interest in machine learning because the employed distance metric can significantly affect the performance of many learning methods. Quadratic Mahalanobis metric learning is a popular approach to the problem, but typically requires solving a semidefinite programming (SDP) problem, which is computationally expensive. The worst case complexity of solving an SDP problem involving a matrix variable of size D×D with O(D) linear constraints is about O(D(6.5)) using interior-point methods, where D is the dimension of the input data. Thus, the interior-point methods only practically solve problems exhibiting less than a few thousand variables. Because the number of variables is D(D+1)/2, this implies a limit upon the size of problem that can practically be solved around a few hundred dimensions. The complexity of the popular quadratic Mahalanobis metric learning approach thus limits the size of problem to which metric learning can be applied. Here, we propose a significantly more efficient and scalable approach to the metric learning problem based on the Lagrange dual formulation of the problem. The proposed formulation is much simpler to implement, and therefore allows much larger Mahalanobis metric learning problems to be solved. The time complexity of the proposed method is roughly O(D(3)), which is significantly lower than that of the SDP approach. Experiments on a variety of data sets demonstrate that the proposed method achieves an accuracy comparable with the state of the art, but is applicable to significantly larger problems. We also show that the proposed method can be applied to solve more general Frobenius norm regularized SDP problems approximately.

Bounding Averages Rigorously Using Semidefinite Programming: Mean Moments of the Lorenz System

NASA Astrophysics Data System (ADS)

Goluskin, David

2018-04-01

We describe methods for proving bounds on infinite-time averages in differential dynamical systems. The methods rely on the construction of nonnegative polynomials with certain properties, similarly to the way nonlinear stability can be proved using Lyapunov functions. Nonnegativity is enforced by requiring the polynomials to be sums of squares, a condition which is then formulated as a semidefinite program (SDP) that can be solved computationally. Although such computations are subject to numerical error, we demonstrate two ways to obtain rigorous results: using interval arithmetic to control the error of an approximate SDP solution, and finding exact analytical solutions to relatively small SDPs. Previous formulations are extended to allow for bounds depending analytically on parametric variables. These methods are illustrated using the Lorenz equations, a system with three state variables ( x, y, z) and three parameters (β ,σ ,r). Bounds are reported for infinite-time averages of all eighteen moments x^ly^mz^n up to quartic degree that are symmetric under (x,y)\\mapsto (-x,-y). These bounds apply to all solutions regardless of stability, including chaotic trajectories, periodic orbits, and equilibrium points. The analytical approach yields two novel bounds that are sharp: the mean of z^3 can be no larger than its value of (r-1)^3 at the nonzero equilibria, and the mean of xy^3 must be nonnegative. The interval arithmetic approach is applied at the standard chaotic parameters to bound eleven average moments that all appear to be maximized on the shortest periodic orbit. Our best upper bound on each such average exceeds its value on the maximizing orbit by less than 1%. Many bounds reported here are much tighter than would be possible without computer assistance.

Controlling Light Transmission Through Highly Scattering Media Using Semi-Definite Programming as a Phase Retrieval Computation Method.

PubMed

N'Gom, Moussa; Lien, Miao-Bin; Estakhri, Nooshin M; Norris, Theodore B; Michielssen, Eric; Nadakuditi, Raj Rao

2017-05-31

Complex Semi-Definite Programming (SDP) is introduced as a novel approach to phase retrieval enabled control of monochromatic light transmission through highly scattering media. In a simple optical setup, a spatial light modulator is used to generate a random sequence of phase-modulated wavefronts, and the resulting intensity speckle patterns in the transmitted light are acquired on a camera. The SDP algorithm allows computation of the complex transmission matrix of the system from this sequence of intensity-only measurements, without need for a reference beam. Once the transmission matrix is determined, optimal wavefronts are computed that focus the incident beam to any position or sequence of positions on the far side of the scattering medium, without the need for any subsequent measurements or wavefront shaping iterations. The number of measurements required and the degree of enhancement of the intensity at focus is determined by the number of pixels controlled by the spatial light modulator.

Finding Bayesian Optimal Designs for Nonlinear Models: A Semidefinite Programming-Based Approach.

PubMed

Duarte, Belmiro P M; Wong, Weng Kee

2015-08-01

This paper uses semidefinite programming (SDP) to construct Bayesian optimal design for nonlinear regression models. The setup here extends the formulation of the optimal designs problem as an SDP problem from linear to nonlinear models. Gaussian quadrature formulas (GQF) are used to compute the expectation in the Bayesian design criterion, such as D-, A- or E-optimality. As an illustrative example, we demonstrate the approach using the power-logistic model and compare results in the literature. Additionally, we investigate how the optimal design is impacted by different discretising schemes for the design space, different amounts of uncertainty in the parameter values, different choices of GQF and different prior distributions for the vector of model parameters, including normal priors with and without correlated components. Further applications to find Bayesian D-optimal designs with two regressors for a logistic model and a two-variable generalised linear model with a gamma distributed response are discussed, and some limitations of our approach are noted.

Finding Bayesian Optimal Designs for Nonlinear Models: A Semidefinite Programming-Based Approach

PubMed Central

Duarte, Belmiro P. M.; Wong, Weng Kee

2014-01-01

Summary This paper uses semidefinite programming (SDP) to construct Bayesian optimal design for nonlinear regression models. The setup here extends the formulation of the optimal designs problem as an SDP problem from linear to nonlinear models. Gaussian quadrature formulas (GQF) are used to compute the expectation in the Bayesian design criterion, such as D-, A- or E-optimality. As an illustrative example, we demonstrate the approach using the power-logistic model and compare results in the literature. Additionally, we investigate how the optimal design is impacted by different discretising schemes for the design space, different amounts of uncertainty in the parameter values, different choices of GQF and different prior distributions for the vector of model parameters, including normal priors with and without correlated components. Further applications to find Bayesian D-optimal designs with two regressors for a logistic model and a two-variable generalised linear model with a gamma distributed response are discussed, and some limitations of our approach are noted. PMID:26512159

The Spin-Plane Double Probe Electric Field Instrument for MMS

NASA Astrophysics Data System (ADS)

Lindqvist, P.-A.; Olsson, G.; Torbert, R. B.; King, B.; Granoff, M.; Rau, D.; Needell, G.; Turco, S.; Dors, I.; Beckman, P.; Macri, J.; Frost, C.; Salwen, J.; Eriksson, A.; Åhlén, L.; Khotyaintsev, Y. V.; Porter, J.; Lappalainen, K.; Ergun, R. E.; Wermeer, W.; Tucker, S.

2016-03-01

The Spin-plane double probe instrument (SDP) is part of the FIELDS instrument suite of the Magnetospheric Multiscale mission (MMS). Together with the Axial double probe instrument (ADP) and the Electron Drift Instrument (EDI), SDP will measure the 3-D electric field with an accuracy of 0.5 mV/m over the frequency range from DC to 100 kHz. SDP consists of 4 biased spherical probes extended on 60 m long wire booms 90∘ apart in the spin plane, giving a 120 m baseline for each of the two spin-plane electric field components. The mechanical and electrical design of SDP is described, together with results from ground tests and calibration of the instrument.

Scientific Data Purchase Project Overview Presentation

NASA Technical Reports Server (NTRS)

Holekamp, Kara; Fletcher, Rose

2001-01-01

The Scientific Data Purchase (SDP) project acquires science data from commercial sources. It is a demonstration project to test a new way of doing business, tap new sources of data, support Earth science research, and support the commercial remote sensing industry. Phase I of the project reviews simulated/prototypical data sets from 10 companies. Phase II of the project is a 3 year purchase/distribution of select data from 5 companies. The status of several SDP projects is reviewed in this viewgraph presentation, as is the SDP process of tasking, verification, validation, and data archiving. The presentation also lists SDP results for turnaround time, metrics, customers, data use, science research, applications research, and user feedback.

Spectral-domain Optical Coherence Tomography in Manifest Glaucoma: Its Additive Role in Structural Diagnosis.

PubMed

Kim, Ko Eun; Oh, Sohee; Jeoung, Jin Wook; Suh, Min Hee; Seo, Je Hyun; Kim, Martha; Park, Ki Ho; Kim, Dong Myung; Kim, Seok Hwan

2016-11-01

To investigate the additive role of spectral-domain optical coherence tomography (SDOCT) in the structural diagnosis in glaucoma. Reliability and validity analysis. Structural examinations from 109 eyes of 109 healthy individuals and 151 eyes of 151 glaucoma patients with different severities were included. Four structural-diagnostic examination sets were prepared using stereo-optic disc photography (SDP), red-free retinal nerve fiber layer photography (RNFLP), and SDOCT: (1) SDP (S), (2) SDP and SDOCT (SO), (3) SDP and RNFLP (SR), and (4) SDP, RNFLP, and SDOCT (SRO). Five glaucoma specialists were instructed to classify subjects as normal or glaucoma using each of the 4 diagnostic sets in the order S, SO, SR, and SRO, with a 1-month interval. The interobserver agreement was evaluated using kappa (κ) statistics. The additive effect of SDOCT on the diagnostic performance of the specialists was evaluated using the generalized estimating equation. Five glaucoma specialists showed an excellent level of interobserver agreement on the diagnostic assessments based on the 4 sets. In the comparison of the collective diagnostic performance of the specialists, addition of SDOCT to SDP showed an approximately 2-fold significant increase in the diagnostic accuracy. Adding SDOCT to SDP significantly enhanced the specialists' structural-diagnostic ability with respect to the moderate glaucoma, though not mild or advanced glaucoma. SDOCT significantly enhanced the diagnostic accuracy of the glaucoma specialists' performance, showing its additive diagnostic value in judging glaucomatous structural damage, especially in the moderate stage of glaucoma. Copyright © 2016 Elsevier Inc. All rights reserved.

"New Skills and Abilities to Enable Me to Support My Pupils in a Forward Thinking Positive Way:" A Self-Discovery Programme for Teachers in Mainstream School

ERIC Educational Resources Information Center

Powell, Lesley; Cheshire, Anna

2008-01-01

The purpose of this study is to adapt, deliver, and pilot test the Self-discovery Programme (SDP) for teachers in mainstream school. The study used a pre-test post-test design. Quantitative data were collected by self-administered questionnaires given to teachers at two points in time: baseline (immediately pre-SDP) and immediately post-SDP.…

Assessment of Modifications for Improving Navigation at Hilo Harbor, Hawaii

DTIC Science & Technology

2016-06-01

ER D C/ CH L TR -1 6- 9 Coastal Inlets Research Program Assessment of Modifications for Improving Navigation at Hilo Harbor, Hawaii...at http://acwc.sdp.sirsi.net/client/default. Coastal Inlets Research Program ERDC/CHL TR-16-9 June 2016 Assessment of Modifications for Improving...validation with 2013–2014 field data ................................................. 86 4.5.3 Chile tsunami effect on Hilo Harbor

Hawaii Regional Sediment Management (RSM): Regional Sediment Budget for the West Maui Region

DTIC Science & Technology

2016-06-01

Increased sedimentation associated with loss of forest land, historical agriculture practices, stream channelization , and rapid development has...ER D C/ CH L TR -1 6- 5 Regional Sediment Management (RSM) Program Hawaii Regional Sediment Management (RSM): Regional Sediment Budget...acwc.sdp.sirsi.net/client/default. Regional Sediment Management (RSM) Program ERDC/CHL TR-16-5 June 2016 Hawaii Regional Sediment Management

Nearshore Placement Techniques in Southern Lake Michigan

DTIC Science & Technology

2018-03-01

ER D C /C HL T R- 18 -3 Regional Sediment Management (RSM) Program Nearshore Placement Techniques in Southern Lake Michigan Co as ta...online library at http://acwc.sdp.sirsi.net/client/default. Regional Sediment Management (RSM) Program ERDC/CHL TR-18-3 March 2018 Nearshore...This study was conducted for Headquarters, U.S. Army Corps of Engineers (HQUSACE), Washington, DC, under the USACE Regional Sediment Management

Effect of Arctic Amplification on Design Snow Loads in Alaska

DTIC Science & Technology

2016-09-01

ER D C/ CR RE L M P- 16 -1 Strategic Environmental Research and Development Program (SERDP) Effect of Arctic Amplification on Design...September 2016 Approved for public release; distribution is unlimited. The U.S. Army Engineer Research and Development Center (ERDC...acwc.sdp.sirsi.net/client/default. Strategic Environmental Research and Development Program (SERDP) ERDC/CRREL MP-16-1 September 2016 Effect of Arctic

Science-based Framework for Environmental Benefits Assessment

DTIC Science & Technology

2013-03-01

ER D C/ EL T R -1 3 -4 Environmental Benefits Analysis Program Science-based Framework for Environmental Benefits Assessment E nv ir...acwc.sdp.sirsi.net/client/default. Environmental Benefits Analysis Program ERDC/EL TR-13-4 March 2013 Science-based Framework for Environmental Benefits ...evaluating ecosystem restoration benefits within the context of USACE Civil Works planning process. An emphasis is placed on knowledge gained from

Scalable Nonparametric Low-Rank Kernel Learning Using Block Coordinate Descent.

PubMed

Hu, En-Liang; Kwok, James T

2015-09-01

Nonparametric kernel learning (NPKL) is a flexible approach to learn the kernel matrix directly without assuming any parametric form. It can be naturally formulated as a semidefinite program (SDP), which, however, is not very scalable. To address this problem, we propose the combined use of low-rank approximation and block coordinate descent (BCD). Low-rank approximation avoids the expensive positive semidefinite constraint in the SDP by replacing the kernel matrix variable with V(T)V, where V is a low-rank matrix. The resultant nonlinear optimization problem is then solved by BCD, which optimizes each column of V sequentially. It can be shown that the proposed algorithm has nice convergence properties and low computational complexities. Experiments on a number of real-world data sets show that the proposed algorithm outperforms state-of-the-art NPKL solvers.

Hydrodynamic Modeling for Channel and Shoreline Stabilization at Rhodes Point, Smith Island, MD

DTIC Science & Technology

2016-11-01

shorelines. Both Alternatives included the same revetment structure for protecting the south shoreline. The Coastal Modeling System (CMS, including CMS...ER D C/ CH L TR -1 6- 17 Coastal Inlets Research Program Hydrodynamic Modeling for Channel and Shoreline Stabilization at Rhodes Point...acwc.sdp.sirsi.net/client/default. Coastal Inlets Research Program ERDC/CHL TR-16-17 November 2016 Hydrodynamic Modeling for Channel and Shoreline

78 FR 16753 - Service Delivery Plan; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-18

... the first sentence after the words, ``Service Delivery Plan (SDP) insert http://www.ssa.gov/open/SDP... http://ssa.gov/asp/plan-2013-2016.pdf . Paul Kryglik, Director, Office of Regulations, Social Security...

Prenatal smoking exposure and offspring stress coping in late adolescence: no causal link.

PubMed

Kuja-Halkola, Ralf; D'Onofrio, Brian M; Iliadou, Anastasia N; Långström, Niklas; Lichtenstein, Paul

2010-12-01

In utero exposure to tobacco smoking has been suggested to cause persistent alterations in cognitive functioning. We examined if mothers' smoking during pregnancy (SDP) is associated with long-term impairment in offspring stress coping and the causal mechanism behind a possible link. We used a large cohort (n = 187,106) of young males in Sweden (mean age = 18.2 years), who underwent a semi-structured psychological assessment in 1997-2006, including an evaluation of stress coping ability, as part of the compulsory military conscript examination. We compared differentially exposed siblings within nuclear families and cousins in extended families and used multilevel structural equation models to disentangle genetic from environmental contributions to the association between SDP and stress coping. SDP and offspring stress coping was moderately strongly associated when comparing unrelated individuals [regression coefficient (b) = -0.38 on a nine-point scale; 95% confidence interval (CI) -0.40 to -0.36, P < 0.0001]. In contrast, it disappeared when siblings were compared (b = 0.11; 95% CI -0.01 to 0.23, P = 0.071). This familial confounding was entirely due to genetic influences. SDP is an established risk factor for pregnancy- and birth-related complications. However, we found no long-term effect of SDP on offspring stress coping. Rather, the observed association was due to familial confounding of genetic origin; women prone to SDP also transmit genes to their children that are associated with poorer coping with stress.

Dynamic versus static allocation policies in multipurpose multireservoir systems

NASA Astrophysics Data System (ADS)

Tilmant, A.; Goor, Q.; Pinte, D.; van der Zaag, P.

2007-12-01

As the competition for water is likely to increase in the near future due to socioeconomic development and population growth, water resources managers will face hard choices when allocating water between competing users. Because water is a vital resource used in multiple sectors, including the environment, the allocation is inherently a political and social process, which is likely to become increasingly scrutinized as the competition grows between the different sectors. Since markets are usually absent or ineffective, the allocation of water between competing demands is achieved administratively taking into account key objectives such as economic efficiency, equity and maintaining the ecological integrity. When crop irrigation is involved, water is usually allocated by a system of annual rights to use a fixed, static, volume of water. In a fully-allocated basin, moving from a static to a dynamic allocation process, whereby the policies are regularly updated according to the hydrologic status of the river basin, is the first step towards the development of river basin management strategies that increase the productivity of water. More specifically, in a multipurpose multireservoir system, continuously adjusting release and withdrawal decisions based on the latest hydrologic information will increase the benefits derived from the system. However, the extent to which such an adjustment can be achieved results from complex spatial and temporal interactions between the physical characteristics of the water resources system (storage, natural flows), the economic and social consequences of rationing and the impacts on natural ecosystems. The complexity of the decision-making process, which requires the continuous evaluation of numerous trade-offs, calls for the use of integrated hydrologic-economic models. This paper compares static and dynamic management approaches for a cascade of hydropower-irrigation reservoirs using stochastic dual dynamic programming (SDDP) formulations. As its name indicates, SDDP is an extension of SDP that removes the curse of dimensionality found in discrete SDP and can therefore be used to analyze large-scale water resources systems. For the static approach, the multiobjective (irrigation-hydropower) optimization problem is solved using the constraint method, i.e. net benefits from hydropower generation are maximized and irrigation water withdrawals are additional constraints. In the dynamic approach, the SDDP model seeks to maximize the net benefits of both hydropower and irrigation crop production. A cascade of 8 reservoirs in the Turkish and Syrian parts of the Euphrates river basin is used as a case study.

Sustainable dimension adaptation measure in green township assessment criteria

NASA Astrophysics Data System (ADS)

Yaman, R.; Thadaniti, S.; Ahmad, N.; Halil, F. M.; Nasir, N. M.

2018-05-01

Urbanized areas are typically the most significant sources of environmental degradation, thus, an urban assessment criteria tools aiming at equally adapted sustainability dimensions need to be firmly embedded in benchmarking planning and design framework and upon occupancy. The need for integral systematic rating is recognized in order to evaluate the performance of sustainable neighborhood and to promote sustainable urban development. In this study, Green Building Index Township Assessment Criteria (GBI-TAC) will be measure on holistic sustainable dimension pillar (SDP) adaptation in order to assess and redefine the current sustainability assessment criteria for future sustainable neighborhood development (SND). The objective of the research is to find-out whether the current GBI-TAC and its variables fulfilled the holistic SDP adaptations towards sustainable neighborhood development in Malaysia. The stakeholder-inclusion approached is used in this research in order to gather professional’s stakeholders’ opinions regarding the SDP adaptations for sustainable neighborhood development. The data were analysed using IBM SPSS AMOS22 Structural Equation Modelling. The findings suggested an adaptation gap of SDP in current GBI-TAC even though all core-criteria supported SDP adaptation, hence lead to further review and refinement for future Neighborhood Assessment Criteria in Malaysia.

Fan fault diagnosis based on symmetrized dot pattern analysis and image matching

NASA Astrophysics Data System (ADS)

Xu, Xiaogang; Liu, Haixiao; Zhu, Hao; Wang, Songling

2016-07-01

To detect the mechanical failure of fans, a new diagnostic method based on the symmetrized dot pattern (SDP) analysis and image matching is proposed. Vibration signals of 13 kinds of running states are acquired on a centrifugal fan test bed and reconstructed by the SDP technique. The SDP pattern templates of each running state are established. An image matching method is performed to diagnose the fault. In order to improve the diagnostic accuracy, the single template, multiple templates and clustering fault templates are used to perform the image matching.

A formulation of a matrix sparsity approach for the quantum ordered search algorithm

NASA Astrophysics Data System (ADS)

Parmar, Jupinder; Rahman, Saarim; Thiara, Jaskaran

One specific subset of quantum algorithms is Grovers Ordered Search Problem (OSP), the quantum counterpart of the classical binary search algorithm, which utilizes oracle functions to produce a specified value within an ordered database. Classically, the optimal algorithm is known to have a log2N complexity; however, Grovers algorithm has been found to have an optimal complexity between the lower bound of ((lnN-1)/π≈0.221log2N) and the upper bound of 0.433log2N. We sought to lower the known upper bound of the OSP. With Farhi et al. MITCTP 2815 (1999), arXiv:quant-ph/9901059], we see that the OSP can be resolved into a translational invariant algorithm to create quantum query algorithm restraints. With these restraints, one can find Laurent polynomials for various k — queries — and N — database sizes — thus finding larger recursive sets to solve the OSP and effectively reducing the upper bound. These polynomials are found to be convex functions, allowing one to make use of convex optimization to find an improvement on the known bounds. According to Childs et al. [Phys. Rev. A 75 (2007) 032335], semidefinite programming, a subset of convex optimization, can solve the particular problem represented by the constraints. We were able to implement a program abiding to their formulation of a semidefinite program (SDP), leading us to find that it takes an immense amount of storage and time to compute. To combat this setback, we then formulated an approach to improve results of the SDP using matrix sparsity. Through the development of this approach, along with an implementation of a rudimentary solver, we demonstrate how matrix sparsity reduces the amount of time and storage required to compute the SDP — overall ensuring further improvements will likely be made to reach the theorized lower bound.

Review of Ice-Induced Scour Impacts to Navigation and Structures

DTIC Science & Technology

2017-07-17

ER D C SR -1 7- 3 Navigation Systems Research Program Review of Ice-Induced Scour Impacts to Navigation and Structures En gi ne er R...unlimited. The U.S. Army Engineer Research and Development Center (ERDC) solves the nation’s toughest engineering and environmental challenges...reports published by ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/client/default. Navigation Systems Research Program ERDC SR-17

NASA Scientific Data Purchase Project: From Collection to User

NASA Technical Reports Server (NTRS)

Nicholson, Lamar; Policelli, Fritz; Fletcher, Rose

2002-01-01

NASA's Scientific Data Purchase (SDP) project is currently a $70 million operation managed by the Earth Science Applications Directorate at Stennis Space Center. The SDP project was developed in 1997 to purchase scientific data from commercial sources for distribution to NASA Earth science researchers. Our current data holdings include 8TB of remote sensing imagery consisting of 18 products from 4 companies. Our anticipated data volume is 60 TB by 2004, and we will be receiving new data products from several additional companies. Our current system capacity is 24 TB, expandable to 89 TB. Operations include tasking of new data collections, archive ordering, shipment verification, data validation, distribution, metrics, finances, customer feedback, and technical support. The program has been included in the Stennis Space Center Commercial Remote Sensing ISO 9001 registration since its inception. Our operational system includes automatic quality control checks on data received (with MatLab analysis); internally developed, custom Web-based interfaces that tie into commercial-off-the-shelf software; and an integrated relational database that links and tracks all data through operations. We've distributed nearly 1500 datasets, and almost 18,000 data files have been downloaded from our public web site; on a 10-point scale, our customer satisfaction index is 8.32 at a 23% response level. More information about the SDP is available on our Web site.

Within-Family Effects of Smoking during Pregnancy on ADHD: the Importance of Phenotype.

PubMed

Marceau, Kristine; Cinnamon Bidwell, L; Karoly, Hollis C; Evans, Allison Schettini; Todorov, Alexandre A; Palmer, Rohan H; Heath, Andrew C; Knopik, Valerie S

2018-05-01

We sought to test within- and between- family associations of smoking during pregnancy (SDP) and attention deficit-hyperactivity disorder (ADHD) symptoms using a structured interview based on the conventional Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) symptoms and the Strengths and Weaknesses of ADHD-Symptoms and Normal-Behavior (SWAN) scale, which is a population based measure that grew out of the notion that an ADHD diagnosis exists on the extreme end of a continuum of normative behaviors and includes both above- and below- average performance on attention and activity. We used a sibling-comparison approach in a sample of 173 families including siblings aged 7-16 years (52% male) drawn from the state of Missouri, USA, wherein mothers smoked during one pregnancy but not the other. There was a within-family effect of smoking during pregnancy on SWAN hyperactivity/impulsivity and SWAN total ADHD behaviors. The associations between SDP and DSM-IV-based ADHD symptom dimensions as well as SWAN inattention were explained by familial confounds. These findings suggest that SDP exerts a potentially causal effect on increased ADHD hyperactive/impulsive behaviors and that this SDP effect is best captured when hyperactivity/impulsivity is assessed more normatively across the population, rather than specifically assessing problematic behaviors via DSM symptoms. Thus, any potentially causal effect of SDP on ADHD symptom dimensions may be restricted to hyperactive/impulsive behaviors rather than inattention, and normative, non-DSM-IV based behavioral measures may provide a more sensitive test of mechanisms of SDP-ADHD symptom associations, particularly in non-clinical samples.

Reduced posterior mesofrontal cortex activation by risky rewards in substance-dependent patients.

PubMed

Bjork, James M; Momenan, Reza; Smith, Ashley R; Hommer, Daniel W

2008-05-01

Substance-dependent individuals show disadvantageous decision-making, as well as alterated frontocortical recruitment when performing experimental tasks. We investigated whether substance-dependent patients (SDP) would show blunted recruitment of posterior mesofrontal cortex (PMC) by a conflict between concurrently increasing reward and risk of penalty in a monetary game of "chicken." SDP and controls performed: motor control (no reward) trials, guaranteed reward trials in which reward was not at risk, and risky trials where subjects were required to terminate their reward accrual before a secret varying time limit or else "bust" and forfeit that trial's winnings (low penalty) or the current trial's winnings plus an equal amount of previous winnings (high penalty). Reward accrual duration at risk of "busting" correlated negatively with trait neuroticism. The contrast between winning guaranteed reward versus non-reward activated the caudate head bilaterally in SDP but not controls. Accumulation of money at risk of low- or high-penalty (contrasted with accumulating guaranteed money) activated the PMC in both groups, but with a greater magnitude and more anterior extent in controls. Pre-decision signal increase in a PMC volume of interest negatively correlated with risk-taking in low-penalty trials, and was blunted in SDP relative to controls under both penalty conditions after controlling for individual differences in actual risk-taking and the higher neuroticism of SDP. These data suggest that SDP are characterized by a combination of: (a) striatal hypersensitivity to reward, and (b) under-recruitment of the specialized conflict-monitoring circuitry of the PMC when reward entails potential penalties.

Combining clinical and magnetic resonance imaging markers enhances prediction of 12-year disability in multiple sclerosis.

PubMed

Uher, Tomas; Vaneckova, Manuela; Sobisek, Lukas; Tyblova, Michaela; Seidl, Zdenek; Krasensky, Jan; Ramasamy, Deepa; Zivadinov, Robert; Havrdova, Eva; Kalincik, Tomas; Horakova, Dana

2017-01-01

Disease progression and treatment efficacy vary among individuals with multiple sclerosis. Reliable predictors of individual disease outcomes are lacking. To examine the accuracy of the early prediction of 12-year disability outcomes using clinical and magnetic resonance imaging (MRI) parameters. A total of 177 patients from the original Avonex-Steroids-Azathioprine study were included. Participants underwent 3-month clinical follow-ups. Cox models were used to model the associations between clinical and MRI markers at baseline or after 12 months with sustained disability progression (SDP) over the 12-year observation period. At baseline, T2 lesion number, T1 and T2 lesion volumes, corpus callosum (CC), and thalamic fraction were the best predictors of SDP (hazard ratio (HR) = 1.7-4.6; p ⩽ 0.001-0.012). At 12 months, Expanded Disability Status Scale (EDSS) and its change, number of new or enlarging T2 lesions, and CC volume % change were the best predictors of SDP over the follow-up (HR = 1.7-3.5; p ⩽  0.001-0.017). A composite score was generated from a subset of the best predictors of SDP. Scores of ⩾4 had greater specificity (90%-100%) and were associated with greater cumulative risk of SDP (HR = 3.2-21.6; p < 0.001) compared to the individual predictors. The combination of established MRI and clinical indices with MRI volumetric predictors improves the prediction of SDP over long-term follow-up and may provide valuable information for therapeutic decisions.

A laboratory-based study on patients with Parkinson's disease and seborrheic dermatitis: the presence and density of Malassezia yeasts, their different species and enzymes production.

PubMed

Arsic Arsenijevic, Valentina S; Milobratovic, Danica; Barac, Aleksandra M; Vekic, Berislav; Marinkovic, Jelena; Kostic, Vladimir S

2014-03-14

Seborrheic dermatitis (SD) and Parkinson's disease (PD) are frequently associated conditions. Aims of this study were: to determine severity of SD, presence of different species and density of Malassezia yeasts; to assess yeast lipases and phosphatases production in vitro and to compare these results between SD patients with and without PD. This case-control prospective study was conducted at the Dermatology and Neurology Units, Clinical Centre of Serbia and at the National Medical Mycology Reference Laboratory, University of Belgrade Medical School, Serbia. A total of 90 patients and 70 healthy controls (HC) were investigated: 60 patients with SD (SDN) and 30 patients with SD and PD (SDP). Culture-based mycological examination was carried out on lesional skin (LS) and non-lesional skin (NLS). A yeasts density was determined by counting the Malassezia colony forming units per tape (CFU/tape). Enzymes production by isolated Malassezia was investigated. The most patients with SD were male (76.7%; SDP and 63.3%; SDN) and the intensity of SD was dominantly severe or moderate (76.7%; SDP and 75%; SDN). The presence of Malasseziа was high on LS in both groups (87.3%; SDP and 86.7%; SDN) (p=0.667).The highest yeasts density (mean CFU/tape=67.8) was detected on LS in 53% of SDP group and in 21.7% of SDN group (mean CFU/tape=31.9) (p < 0.01). The presence of negative cultures was lower in SDP group (13.3%) in comparison to HC and SDN groups (37% and 31.7%, respectively). Malassezia density on NLS in SDP group (mean CFU/tape=44.3) was significantly higher in comparison to SDN and HC (p=0.018). M. globosa was the most abundant species identified amongst isolates from the SDP group (42.3%) and exhibited high production of phosphatase and lipase in vitro. From this laboratory-based study a positive correlation between SD, PD, M. globosa incidence, high yeast density and high phosphatase and lipase activity was established. Our data lead to conclusion that local skin performance of PD patient's characterized with increased sebum excretion ratio play a role in SD by stimulation of yeasts replication and enzyme production.

A laboratory-based study on patients with Parkinson’s disease and seborrheic dermatitis: the presence and density of Malassezia yeasts, their different species and enzymes production

PubMed Central

2014-01-01

Background Seborrheic dermatitis (SD) and Parkinson’s disease (PD) are frequently associated conditions. Aims of this study were: to determine severity of SD, presence of different species and density of Malassezia yeasts; to assess yeast lipases and phosphatases production in vitro and to compare these results between SD patients with and without PD. Methods This case–control prospective study was conducted at the Dermatology and Neurology Units, Clinical Centre of Serbia and at the National Medical Mycology Reference Laboratory, University of Belgrade Medical School, Serbia. A total of 90 patients and 70 healthy controls (HC) were investigated: 60 patients with SD (SDN) and 30 patients with SD and PD (SDP). Culture-based mycological examination was carried out on lesional skin (LS) and non-lesional skin (NLS). A yeasts density was determined by counting the Malassezia colony forming units per tape (CFU/tape). Enzymes production by isolated Malassezia was investigated. Results The most patients with SD were male (76.7%; SDP and 63.3%; SDN) and the intensity of SD was dominantly severe or moderate (76.7%; SDP and 75%; SDN). The presence of Malasseziа was high on LS in both groups (87.3%; SDP and 86.7%; SDN) (p=0.667). The highest yeasts density (mean CFU/tape=67.8) was detected on LS in 53% of SDP group and in 21.7% of SDN group (mean CFU/tape=31.9) (p < 0.01). The presence of negative cultures was lower in SDP group (13.3%) in comparison to HC and SDN groups (37% and 31.7%, respectively). Malassezia density on NLS in SDP group (mean CFU/tape=44.3) was significantly higher in comparison to SDN and HC (p=0.018). M. globosa was the most abundant species identified amongst isolates from the SDP group (42.3%) and exhibited high production of phosphatase and lipase in vitro. Conclusion From this laboratory-based study a positive correlation between SD, PD, M. globosa incidence, high yeast density and high phosphatase and lipase activity was established. Our data lead to conclusion that local skin performance of PD patient’s characterized with increased sebum excretion ratio play a role in SD by stimulation of yeasts replication and enzyme production. PMID:24628775

Grow Your Own School Leaders: A Case Study of Principal Development in Philadelphia Schools

ERIC Educational Resources Information Center

Urban Education Collaborative, 2010

2010-01-01

In 2004-05, the School District of Philadelphia (SDP) began a groundbreaking partnership with the Eli Broad Foundation to develop the Academy for Leadership in Philadelphia Schools (ALPS), one of several Broad-funded, alternative principal development programs initiated across the country. The ALPS effort was designed to respond to two challenges:…

Transforming School Leadership and Management to Support Student Learning and Development: The Field Guide to Comer Schools in Action

ERIC Educational Resources Information Center

Joyner, Edward T., Ed.; Ben-Avie, Michael, Ed.; Comer, James P., Ed.

2004-01-01

For more than 35 years, the Yale School Development Program (SDP) has been pioneering the Comer Process for planned change in schools. From initial planning and preparation, through foundation building, transformation, institutionalization, and renewal, the Comer Process provides school leaders with a comprehensive and effective framework for…

Deployable Engine Air Brake

NASA Technical Reports Server (NTRS)

2014-01-01

On approach, next-generation aircraft are likely to have airframe noise levels that are comparable to or in excess of engine noise. ATA Engineering, Inc. (ATA) is developing a novel quiet engine air brake (EAB), a device that generates "equivalent drag" within the engine through stream thrust reduction by creating a swirling outflow in the turbofan exhaust nozzle. Two Phase II projects were conducted to mature this technology: (1) a concept development program (CDP) and (2) a system development program (SDP).

Efficacy of Pseudomonas fluorescens (Pf-CL145A) spray dried powder for controlling zebra mussels adhering to test substrates

USGS Publications Warehouse

Luoma, James A.; Severson, Todd J.; Weber, Kerry L.; Mayer, Denise A.

2015-01-01

Approximately 30 days after exposure, zebra mussels were sorted into live and dead, and enumerated. Mean survival of zebra mussels in control treatments exceeded 95 percent. Mean survival of zebra mussels in the Lake Carlos WWC SDP-treated groups ranged from 0.5 to 2.1 percent and when compared at the same exposure duration, no difference was detected in survival between the 50 and 100 milligrams per liter (mg/L) treatment groups. Similarly, mean survival of zebra mussels in the Shawano Lake WWC SDP-treated groups ranged from 2.0 to 12.6 percent and when compared at the same exposure duration, no difference was detected in survival between the 50- and 100-mg/L treatment groups. Mean survival of zebra mussels in the Lake Carlos BI trial SDP-treated groups did not differ (p = 0.93) and was 18.1 and 18.0 percent in the 50- and 100-mg/L treatment groups, respectively. Mean survival of zebra mussels in the Shawano Lake BI trial SDP-treated groups differed (p < 0.01) and was 2.9 and 0.9 percent in the 50- and 100-mg/L treatment groups, respectively. Survival of zebra mussels assigned to the SDP-treated groups in the Lake Carlos WWC trial (12-hour exposure duration) differed from the survival of zebra mussels assigned to the SDP-treated groups in the Lake Carlos BI trial; however, after modification of the BI application technique, no difference (p = 0.22) was detected between the survival of zebra mussel in the Shawano Lake WWC (12-hour exposure duration) and BI trials.

Structural and mechanical properties of cardiolipin lipid bilayers determined using neutron spin echo, small angle neutron and X-ray scattering, and molecular dynamics simulations

DOE PAGES

Pan, Jianjun; Cheng, Xiaolin; Sharp, Melissa; ...

2014-10-29

We report that the detailed structural and mechanical properties of a tetraoleoyl cardiolipin (TOCL) bilayer were determined using neutron spin echo (NSE) spectroscopy, small angle neutron and X-ray scattering (SANS and SAXS, respectively), and molecular dynamics (MD) simulations. We used MD simulations to develop a scattering density profile (SDP) model, which was then utilized to jointly refine SANS and SAXS data. In addition to commonly reported lipid bilayer structural parameters, component distributions were obtained, including the volume probability, electron density and neutron scattering length density.

Ensemble Clustering using Semidefinite Programming with Applications

PubMed Central

Singh, Vikas; Mukherjee, Lopamudra; Peng, Jiming; Xu, Jinhui

2011-01-01

In this paper, we study the ensemble clustering problem, where the input is in the form of multiple clustering solutions. The goal of ensemble clustering algorithms is to aggregate the solutions into one solution that maximizes the agreement in the input ensemble. We obtain several new results for this problem. Specifically, we show that the notion of agreement under such circumstances can be better captured using a 2D string encoding rather than a voting strategy, which is common among existing approaches. Our optimization proceeds by first constructing a non-linear objective function which is then transformed into a 0–1 Semidefinite program (SDP) using novel convexification techniques. This model can be subsequently relaxed to a polynomial time solvable SDP. In addition to the theoretical contributions, our experimental results on standard machine learning and synthetic datasets show that this approach leads to improvements not only in terms of the proposed agreement measure but also the existing agreement measures based on voting strategies. In addition, we identify several new application scenarios for this problem. These include combining multiple image segmentations and generating tissue maps from multiple-channel Diffusion Tensor brain images to identify the underlying structure of the brain. PMID:21927539

Ensemble Clustering using Semidefinite Programming with Applications.

PubMed

Singh, Vikas; Mukherjee, Lopamudra; Peng, Jiming; Xu, Jinhui

2010-05-01

In this paper, we study the ensemble clustering problem, where the input is in the form of multiple clustering solutions. The goal of ensemble clustering algorithms is to aggregate the solutions into one solution that maximizes the agreement in the input ensemble. We obtain several new results for this problem. Specifically, we show that the notion of agreement under such circumstances can be better captured using a 2D string encoding rather than a voting strategy, which is common among existing approaches. Our optimization proceeds by first constructing a non-linear objective function which is then transformed into a 0-1 Semidefinite program (SDP) using novel convexification techniques. This model can be subsequently relaxed to a polynomial time solvable SDP. In addition to the theoretical contributions, our experimental results on standard machine learning and synthetic datasets show that this approach leads to improvements not only in terms of the proposed agreement measure but also the existing agreement measures based on voting strategies. In addition, we identify several new application scenarios for this problem. These include combining multiple image segmentations and generating tissue maps from multiple-channel Diffusion Tensor brain images to identify the underlying structure of the brain.

Topography evolution of rough-surface metallic substrates by solution deposition planarization method

NASA Astrophysics Data System (ADS)

Chu, Jingyuan; Zhao, Yue; Liu, Linfei; Wu, Wei; Zhang, Zhiwei; Hong, Zhiyong; Li, Yijie; Jin, Zhijian

2018-01-01

As an emerging technique for surface smoothing, solution deposition planarization (SDP) has recently drawn more attention on the fabrication of the second generation high temperature superconducting (2G-HTS) tapes. In our work, a number of amorphous oxide layers were deposited on electro-polished or mirror-rolled metallic substrates by chemical solution route. Topography evolution of surface defects on these two types of metallic substrates was thoroughly investigated by atomic force microscopy (AFM). It was showed that root mean square roughness values (at 50 × 50 μm2 scanning scale) on both rough substrates reduced to ∼5 nm after coating with SDP-layer. The smoothing effect was mainly attributed to decrease of the depth at grain boundary grooving on the electro-polished metallic substrate. On the mirror-rolled metallic substrates, the amplitude and frequency of the height fluctuation perpendicular to the rolling direction were gradually reduced as depositing more numbers of SDP-layer. A high Jc value of 4.17 MA cm-2 (at 77 K, s.f.) was achieved on a full stack of YBCO/CeO2/IBAD-MgO/SDP-layer/C276 sample. This study enhanced understanding of the topography evolution on the surface defects covered by the SDP-layer, and demonstrated a low-cost route for fabricating IBAD-MgO based YBCO templates with a simplified architecture.

Incorporating teleconnection information into reservoir operating policies using Stochastic Dynamic Programming and a Hidden Markov Model

NASA Astrophysics Data System (ADS)

Turner, Sean; Galelli, Stefano; Wilcox, Karen

2015-04-01

Water reservoir systems are often affected by recurring large-scale ocean-atmospheric anomalies, known as teleconnections, that cause prolonged periods of climatological drought. Accurate forecasts of these events -- at lead times in the order of weeks and months -- may enable reservoir operators to take more effective release decisions to improve the performance of their systems. In practice this might mean a more reliable water supply system, a more profitable hydropower plant or a more sustainable environmental release policy. To this end, climate indices, which represent the oscillation of the ocean-atmospheric system, might be gainfully employed within reservoir operating models that adapt the reservoir operation as a function of the climate condition. This study develops a Stochastic Dynamic Programming (SDP) approach that can incorporate climate indices using a Hidden Markov Model. The model simulates the climatic regime as a hidden state following a Markov chain, with the state transitions driven by variation in climatic indices, such as the Southern Oscillation Index. Time series analysis of recorded streamflow data reveals the parameters of separate autoregressive models that describe the inflow to the reservoir under three representative climate states ("normal", "wet", "dry"). These models then define inflow transition probabilities for use in a classic SDP approach. The key advantage of the Hidden Markov Model is that it allows conditioning the operating policy not only on the reservoir storage and the antecedent inflow, but also on the climate condition, thus potentially allowing adaptability to a broader range of climate conditions. In practice, the reservoir operator would effect a water release tailored to a specific climate state based on available teleconnection data and forecasts. The approach is demonstrated on the operation of a realistic, stylised water reservoir with carry-over capacity in South-East Australia. Here teleconnections relating to both the El Niño Southern Oscillation and the Indian Ocean Dipole influence local hydro-meteorological processes; statistically significant lag correlations have already been established. Simulation of the derived operating policies, which are benchmarked against standard policies conditioned on the reservoir storage and the antecedent inflow, demonstrates the potential of the proposed approach. Future research will further develop the model for sensitivity analysis and regional studies examining the economic value of incorporating long range forecasts into reservoir operation.

Optimizing basin-scale coupled water quantity and water quality man-agement with stochastic dynamic programming

NASA Astrophysics Data System (ADS)

Davidsen, Claus; Liu, Suxia; Mo, Xingguo; Engelund Holm, Peter; Trapp, Stefan; Rosbjerg, Dan; Bauer-Gottwein, Peter

2015-04-01

Few studies address water quality in hydro-economic models, which often focus primarily on optimal allocation of water quantities. Water quality and water quantity are closely coupled, and optimal management with focus solely on either quantity or quality may cause large costs in terms of the oth-er component. In this study, we couple water quality and water quantity in a joint hydro-economic catchment-scale optimization problem. Stochastic dynamic programming (SDP) is used to minimize the basin-wide total costs arising from water allocation, water curtailment and water treatment. The simple water quality module can handle conservative pollutants, first order depletion and non-linear reactions. For demonstration purposes, we model pollutant releases as biochemical oxygen demand (BOD) and use the Streeter-Phelps equation for oxygen deficit to compute the resulting min-imum dissolved oxygen concentrations. Inelastic water demands, fixed water allocation curtailment costs and fixed wastewater treatment costs (before and after use) are estimated for the water users (agriculture, industry and domestic). If the BOD concentration exceeds a given user pollution thresh-old, the user will need to pay for pre-treatment of the water before use. Similarly, treatment of the return flow can reduce the BOD load to the river. A traditional SDP approach is used to solve one-step-ahead sub-problems for all combinations of discrete reservoir storage, Markov Chain inflow clas-ses and monthly time steps. Pollution concentration nodes are introduced for each user group and untreated return flow from the users contribute to increased BOD concentrations in the river. The pollutant concentrations in each node depend on multiple decision variables (allocation and wastewater treatment) rendering the objective function non-linear. Therefore, the pollution concen-tration decisions are outsourced to a genetic algorithm, which calls a linear program to determine the remainder of the decision variables. This hybrid formulation keeps the optimization problem computationally feasible and represents a flexible and customizable method. The method has been applied to the Ziya River basin, an economic hotspot located on the North China Plain in Northern China. The basin is subject to severe water scarcity, and the rivers are heavily polluted with wastewater and nutrients from diffuse sources. The coupled hydro-economic optimiza-tion model can be used to assess costs of meeting additional constraints such as minimum water qual-ity or to economically prioritize investments in waste water treatment facilities based on economic criteria.

3-D Printed Ultem 9085 Testing and Analysis

NASA Technical Reports Server (NTRS)

Aguilar, Daniel; Christensen, Sean; Fox, Emmet J.

2015-01-01

The purpose of this document is to analyze the mechanical properties of 3-D printed Ultem 9085. This document will focus on the capabilities, limitations, and complexities of 3D printing in general, and explain the methods by which this material is tested. Because 3-D printing is a relatively new process that offers an innovative means to produce hardware, it is important that the aerospace community understands its current advantages and limitations, so that future endeavors involving 3-D printing may be completely safe. This document encompasses three main sections: a Slosh damage assessment, a destructive test of 3-D printed Ultem 9085 samples, and a test to verify simulation for the 3-D printed SDP (SPHERES Docking Port). Described below, 'Slosh' and 'SDP' refer to two experiments that are built using Ultem 9085 for use with the SPHERES (Synchronized Position Hold, Engage, Reorient, Experimental Satellites) program onboard the International Space Station (ISS) [16]. The SPHERES Facility is managed out of the National Aeronautics and Space Administration (NASA) Ames Research Center in California.

Examining the Educative Aims and Practices of Decision-Makers in Sport for Development and Peace Organizations

ERIC Educational Resources Information Center

Svensson, Per G.; Hancock, Meg G.; Hums, Mary A.

2016-01-01

Sport for Development and Peace (SDP) policy-makers and practitioners continue to offer ambitious claims regarding the potential role of sport-based programs for promoting social change. Yet, it is important to put sport under a critical lens in order to develop a more balanced and realistic understanding of the role of sport in society. Whether…

Essentials of Literacy: From A Pilot Site at Davis Street School To District-Wide Intervention

ERIC Educational Resources Information Center

Brown, Fay E.; Murray, Edward T.

2005-01-01

Since the mid 1990s, reading instruction has changed and so has the School Development Program's (SDP) Essentials of Literacy (EOL) process. Beginning as a teaching suggestion at one New Haven, Connecticut school, Lincoln Bassett, EOL became a pilot project at Davis Street School in New Haven for the 1996-1997 school year and continues to be an…

Results of 17 Independent Geopositional Accuracy Assessments of Earth Satellite Corporation's GeoCover Landsat Thematic Mapper Imagery. Geopositional Accuracy Validation of Orthorectified Landsat TM Imagery: Northeast Asia

NASA Technical Reports Server (NTRS)

Smith, Charles M.

2003-01-01

This report provides results of an independent assessment of the geopositional accuracy of the Earth Satellite (EarthSat) Corporation's GeoCover, Orthorectified Landsat Thematic Mapper (TM) imagery over Northeast Asia. This imagery was purchased through NASA's Earth Science Enterprise (ESE) Scientific Data Purchase (SDP) program.

A Research Brief: "Principals' Hiring of Teachers in Philadelphia"

ERIC Educational Resources Information Center

Ramirez, Heidi A.; Schofield, Lynne Steuerle; Black, Melissa

2008-01-01

The School District of Philadelphia (SDP), like many other urban school districts, struggles to increase its hiring and retention of experienced and highly qualified teachers in its low-performing/high-need schools. Excluding its charter schools, SDP serves approximately 165,000 students, largely from high-poverty (76%) and minority (85%)…

Inhibitory Control in Siblings Discordant for Exposure to Maternal Smoking during Pregnancy

ERIC Educational Resources Information Center

Micalizzi, Lauren; Marceau, Kristine; Brick, Leslie A.; Palmer, Rohan H.; Todorov, Alexandre A.; Heath, Andrew C.; Evans, Allison; Knopik, Valerie S.

2018-01-01

Maternal smoking during pregnancy (SDP) has been linked to poorer offspring executive function across development, but SDP does not occur independent of other familial risk factors. As such, poor and inconsistent control for potential confounds, notably shared familial (i.e., genetic and environmental) confounds, preclude concluding causal effects…

Considering the Spatial Layout Information of Bag of Features (BoF) Framework for Image Classification.

PubMed

Mu, Guangyu; Liu, Ying; Wang, Limin

2015-01-01

The spatial pooling method such as spatial pyramid matching (SPM) is very crucial in the bag of features model used in image classification. SPM partitions the image into a set of regular grids and assumes that the spatial layout of all visual words obey the uniform distribution over these regular grids. However, in practice, we consider that different visual words should obey different spatial layout distributions. To improve SPM, we develop a novel spatial pooling method, namely spatial distribution pooling (SDP). The proposed SDP method uses an extension model of Gauss mixture model to estimate the spatial layout distributions of the visual vocabulary. For each visual word type, SDP can generate a set of flexible grids rather than the regular grids from the traditional SPM. Furthermore, we can compute the grid weights for visual word tokens according to their spatial coordinates. The experimental results demonstrate that SDP outperforms the traditional spatial pooling methods, and is competitive with the state-of-the-art classification accuracy on several challenging image datasets.

Pre-movement gating of somatosensory evoked potentials in Segawa disease.

PubMed

Kimura, Kazue; Nagao, Yuri; Hachimori, Kei; Hayashi, Masaharu; Nomura, Yoshiko; Segawa, Masaya

2016-01-01

Segawa disease (SD), an autosomal dominant dopa-responsive dystonia with marked diurnal fluctuation, can be clinically classified into the postural dystonia type (SD-P) and action dystonia type (SD-A). Compared to SD-A, SD-P has an earlier onset and is characterized by postural dystonia. In SD-A, along with postural dystonia, dystonic movements appear in late childhood. To evaluate the differences between these two types of SD, we studied the gating of SEPs, which is useful to investigate sensory-motor integration and might be one of the methods to detect the thalamo-cortical involvement. Fourteen patients with SD (11-63 years) and 18 age-matched normal subjects (11-51 years) were studied. Among the 14 patients with SD, 8 patients had SD-P and 6 had SD-A. Using median nerve stimulation at the wrist, the amplitude of the frontal N30 (FrN30) was compared between pre-movement and rest conditions. We found that the amplitude of the contralateral FrN30 was attenuated before movement in normal controls and in the majority of both SD types. On the other hand, the pre-movement-rest amplitude ratio in patients with SD-A was significantly larger than in patients with SD-P (P=0.0025). No significant differences were observed in the pre-movement-rest ratio between SD-P and normal subjects. The preservation or impairment of pre-movement gating shown here suggests a physiological difference between the two types of SD. More specifically, sensorimotor integration of the basal ganglia-thalamo-cortical circuits may be intact in SD-P, but are affected in SD-A. We discuss the different pathophysiology seen in the different phenotype of SD based on the different developmental involvement in the basal ganglia. Copyright © 2015 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

Is Maternal Smoking during Pregnancy a Causal Environmental Risk Factor for Adolescent Antisocial Behavior? Testing Etiological Theories and Assumptions

PubMed Central

D'Onofrio, Brian M.; Van Hulle, Carol A.; Goodnight, Jackson A.; Rathouz, Paul J.; Lahey, Benjamin B.

2013-01-01

Background Although many studies indicate that maternal smoking during pregnancy (SDP) is correlated with later offspring antisocial behavior (ASB), recent quasi-experimental studies suggest that background familial factors confound the association. The present study sought to test alternative etiological hypotheses using multiple indices of adolescent ASB, comparing differentially exposed siblings, and testing assumptions in the sibling-comparison design. Methods The study examined the association between maternal SDP and adolescent-reported ASB, criminal convictions, and membership in a group of individuals with early-starting and chronic ASB among 6,066 offspring of women from the National Longitudinal Survey of Youth, a representative sample of women in the United States. The analyses controlled for statistical covariates and examined associations while comparing differentially exposed siblings. Results At the population-level, each additional pack of cigarettes/day predicted greater mean adolescent-reported ASB symptoms (ratio of means=1.15, 95% CIs=1.08–1.22), odds of being in the top 10% of ASB (OR=1.34, 95% CIs=1.10–1.65), hazard of a criminal conviction (HR=1.51, 95% CIs=1.34–1.68), and odds of chronic ASB (OR=1.57, 95% CIs=1.25–1.99). SDP robustly predicted most assessments of ASB while controlling for measured covariates. When siblings exposed to differing levels of SDP were compared, however, all of the associations were attenuated and were not statistically significant: adolescent-reported mean ASB (ratio of means=0.86, 95% CIs=0.74–1.01), High ASB (OR=0.67, 95% CIs=0.41–1.12), criminal conviction (HR=0.98, 95% CIs=0.66–1.44), and Chronic ASB (OR=0.80, 95% CIs=0.46–1.38). Conclusions The results strongly suggest that familial factors account for the correlation between SDP and offspring adolescent ASB, rather than a putative causal environmental influence of SDP. PMID:22085725

Surveys for Biological Control Agents of Hydrilla verticillata in the People’s Republic of China in 2013

DTIC Science & Technology

2017-03-01

Hydrilla was rare at this site and only male plants were collected at 0.5-1 m from shore and a depth of 0.5-1m. The lake/wetlands were explored by boat...ER D C/ EL T R- 17 -3 Aquatic Plant Control Research Program Surveys for Biological Control Agents of Hydrilla verticillata in the...acwc.sdp.sirsi.net/client/default. Aquatic Plant Control Research Program ERDC/EL TR-17-3 March 2017 Surveys for Biological Control Agents of

The Self-Discovery Programme for Children with Special Educational Needs in Mainstream Primary and Secondary Schools: An Exploratory Study

ERIC Educational Resources Information Center

Cullen-Powell, Lesley; Barlow, Julie; Bagh, Jagrup

2005-01-01

This exploratory study concerns the Self-Discovery Programme (SDP) designed for children with emotional and behavioural difficulties in mainstream schools. The aim of the SDP is to provide children with a range of practical relaxation skills that may enhance emotional wellbeing, increase self-awareness and promote self-regulatory behaviour.…

A Quasi-Experimental Study of Maternal Smoking during Pregnancy and Offspring Academic Achievement

ERIC Educational Resources Information Center

D'Onofrio, Brian M.; Singh, Amber L.; Iliadou, Anastasia; Lambe, Mats; Hultman, Christina M.; Neiderhiser, Jenae M.; Langstrom, Niklas; Lichtenstein, Paul

2010-01-01

The current study, based on all births in Sweden from 1983 to 1991 (N = 654,707), explored the processes underlying the association between smoking during pregnancy (SDP) and offspring school grades and mathematic proficiency at age 15. The analyses compared relatives who varied in their exposure to SDP and who varied in their genetic relatedness.…

Bioaccessibility in vitro of nutraceuticals from bark of selected Salix species.

PubMed

Gawlik-Dziki, Urszula; Sugier, Danuta; Dziki, Dariusz; Sugier, Piotr

2014-01-01

The aim of this study was to investigate and to compare the extractability, bioaccessibility, and bioavailability in vitro of antioxidative compounds from bark of selected Salix species: S. alba (SA), S. daphnoides (SD), S. purpurea (SP), and S. daphnoides x purpurea (SDP) hybrid willow clones originating from their natural habitats and cultivated on the sandy soil. The highest amount of phenolic glycosides was found in the bark of SDP and SD. The best source of phenolics was bark of SDP. The highest content of flavonoids were found in SD bark samples, whereas the highest concentration of bioaccessible and bioavailable phenolic acids was determined in SDP bark. Bark of all tested Salix species showed significant antiradical activity. This properties are strongly dependent on extraction system and genetic factors. Regardless of Salix genotypes, the lowest chelating power was found for chemically-extractable compounds. Bark of all Salix species contained ethanol-extractable compounds with reducing ability. Besides this, high bioaccessibility and bioavailability in vitro of Salix bark phytochemicals were found. Obtained results indicate that extracts from bark tested Salix genotypes can provide health promoting benefits to the consumers; however, this problem requires further study.

Bioaccessibility In Vitro of Nutraceuticals from Bark of Selected Salix Species

PubMed Central

2014-01-01

The aim of this study was to investigate and to compare the extractability, bioaccessibility, and bioavailability in vitro of antioxidative compounds from bark of selected Salix species: S. alba (SA), S. daphnoides (SD), S. purpurea (SP), and S. daphnoides x purpurea (SDP) hybrid willow clones originating from their natural habitats and cultivated on the sandy soil. The highest amount of phenolic glycosides was found in the bark of SDP and SD. The best source of phenolics was bark of SDP. The highest content of flavonoids were found in SD bark samples, whereas the highest concentration of bioaccessible and bioavailable phenolic acids was determined in SDP bark. Bark of all tested Salix species showed significant antiradical activity. This properties are strongly dependent on extraction system and genetic factors. Regardless of Salix genotypes, the lowest chelating power was found for chemically-extractable compounds. Bark of all Salix species contained ethanol-extractable compounds with reducing ability. Besides this, high bioaccessibility and bioavailability in vitro of Salix bark phytochemicals were found. Obtained results indicate that extracts from bark tested Salix genotypes can provide health promoting benefits to the consumers; however, this problem requires further study. PMID:24696660

Applications of polynomial optimization in financial risk investment

NASA Astrophysics Data System (ADS)

Zeng, Meilan; Fu, Hongwei

2017-09-01

Recently, polynomial optimization has many important applications in optimization, financial economics and eigenvalues of tensor, etc. This paper studies the applications of polynomial optimization in financial risk investment. We consider the standard mean-variance risk measurement model and the mean-variance risk measurement model with transaction costs. We use Lasserre's hierarchy of semidefinite programming (SDP) relaxations to solve the specific cases. The results show that polynomial optimization is effective for some financial optimization problems.

A Journey of Self-Discovery: An Intervention Involving Massage, Yoga and Relaxation for Children with Emotional and Behavioural Difficulties Attending Primary Schools

ERIC Educational Resources Information Center

Powell, Lesley; Gilchrist, Mollie; Stapley, Jacqueline

2008-01-01

This study reports on an intervention involving massage, yoga and relaxation delivered to young children with emotional and behavioural difficulties. Children (n = 126) were invited to participate in the Self-discovery Programme (SDP) with parental consent. A total of 107 children aged 8-11 years completed the SDP and all measures. Children were…

Trade-Offs between the Top-Down and Bottom-Up School Education Management Models: The Implementation of School Development Planning in Western China

ERIC Educational Resources Information Center

Zhu, Zhiyong

2008-01-01

In the 1990s, numerous primary and secondary schools in China began experimental exploration and research on the implementation of school development planning (SDP). However, there has been a lack of self-criticism and reflection on the actual implementation situations and changes in SDP's concepts in the participating schools. This study assessed…

Familial confounding of the association between maternal smoking during pregnancy and offspring substance use and problems.

PubMed

D'Onofrio, Brian M; Rickert, Martin E; Langström, Niklas; Donahue, Kelly L; Coyne, Claire A; Larsson, Henrik; Ellingson, Jarrod M; Van Hulle, Carol A; Iliadou, Anastasia N; Rathouz, Paul J; Lahey, Benjamin B; Lichtenstein, Paul

2012-11-01

Previous epidemiological, animal, and human cognitive neuroscience research suggests that maternal smoking during pregnancy (SDP) causes increased risk of substance use/problems in offspring. To determine the extent to which the association between SDP and offspring substance use/problems depends on confounded familial background factors by using a quasi-experimental design. We used 2 separate samples from the United States and Sweden. The analyses prospectively predicted multiple indices of substance use and problems while controlling for statistical covariates and comparing differentially exposed siblings to minimize confounding. Offspring of a representative sample of women in the United States (sample 1) and the total Swedish population born during the period from January 1, 1983, to December 31, 1995 (sample 2). Adolescent offspring of the women in the National Longitudinal Survey of Youth 1979 (n = 6904) and all offspring born in Sweden during the 13-year period (n = 1,187,360). Self-reported adolescent alcohol, cigarette, and marijuana use and early onset (before 14 years of age) of each substance (sample 1) and substance-related convictions and hospitalizations for an alcohol- or other drug-related problem (sample 2). The same pattern emerged for each index of substance use/problems across the 2 samples. At the population level, maternal SDP predicted every measure of offspring substance use/problems in both samples, ranging from adolescent alcohol use (hazard ratio [HR](moderate), 1.32 [95% CI, 1.22-1.43]; HR(high), 1.33 [1.17-1.53]) to a narcotics-related conviction (HR(moderate), 2.23 [2.14-2.31]; HR(high), 2.97 [2.86-3.09]). When comparing differentially exposed siblings to minimize genetic and environmental confounds, however, the association between SDP and each measure of substance use/problems was minimal and not statistically significant. The association between maternal SDP and offspring substance use/problems is likely due to familial background factors, not a causal influence, because siblings have similar rates of substance use and problems regardless of their specific exposure to SDP.

Multi-objective optimal dispatch of distributed energy resources

NASA Astrophysics Data System (ADS)

Longe, Ayomide

This thesis is composed of two papers which investigate the optimal dispatch for distributed energy resources. In the first paper, an economic dispatch problem for a community microgrid is studied. In this microgrid, each agent pursues an economic dispatch for its personal resources. In addition, each agent is capable of trading electricity with other agents through a local energy market. In this paper, a simple market structure is introduced as a framework for energy trades in a small community microgrid such as the Solar Village. It was found that both sellers and buyers benefited by participating in this market. In the second paper, Semidefinite Programming (SDP) for convex relaxation of power flow equations is used for optimal active and reactive dispatch for Distributed Energy Resources (DER). Various objective functions including voltage regulation, reduced transmission line power losses, and minimized reactive power charges for a microgrid are introduced. Combinations of these goals are attained by solving a multiobjective optimization for the proposed ORPD problem. Also, both centralized and distributed versions of this optimal dispatch are investigated. It was found that SDP made the optimal dispatch faster and distributed solution allowed for scalability.

Reactor technology assessment and selection utilizing systems engineering approach

NASA Astrophysics Data System (ADS)

Zolkaffly, Muhammed Zulfakar; Han, Ki-In

2014-02-01

The first Nuclear power plant (NPP) deployment in a country is a complex process that needs to consider technical, economic and financial aspects along with other aspects like public acceptance. Increased interest in the deployment of new NPPs, both among newcomer countries and those with expanding programs, necessitates the selection of reactor technology among commercially available technologies. This paper reviews the Systems Decision Process (SDP) of Systems Engineering and applies it in selecting the most appropriate reactor technology for the deployment in Malaysia. The integrated qualitative and quantitative analyses employed in the SDP are explored to perform reactor technology assessment and to select the most feasible technology whose design has also to comply with the IAEA standard requirements and other relevant requirements that have been established in this study. A quick Malaysian case study result suggests that the country reside with PWR (pressurized water reactor) technologies with more detailed study to be performed in the future for the selection of the most appropriate reactor technology for Malaysia. The demonstrated technology assessment also proposes an alternative method to systematically and quantitatively select the most appropriate reactor technology.

Detection of Lensing Substructure Using Alma Observations of the Dusty Galaxy SDP.81

DOE PAGES

Hezaveh, Yashar D.; Dalal, Neal; Marrone, Daniel P.; ...

2016-05-19

We study the abundance of substructure in the matter density near galaxies using ALMA Science Verification observations of the strong lensing system SDP.81. We present a method to measure the abundance of subhalos around galaxies using interferometric observations of gravitational lenses. Using simulated ALMA observations we explore the effects of various systematics, including antenna phase errors and source priors, and show how such errors may be measured or marginalized. We apply our formalism to ALMA observations of SDP.81. We find evidence for the presence of a M = 10 8.96±0.12 M ⊙ subhalo near one of the images, with amore » significance of 6.9σ in a joint fit to data from bands 6 and 7; the effect of the subhalo is also detected in both bands individually. We also derive constraints on the abundance of dark matter (DM) subhalos down to M ~ 2 × 10 7 M ⊙, pushing down to the mass regime of the smallest detected satellites in the Local Group, where there are significant discrepancies between the observed population of luminous galaxies and predicted DM subhalos. We find hints of additional substructure, warranting further study using the full SDP.81 data set (including, for example, the spectroscopic imaging of the lensed carbon monoxide emission). We compare the results of this search to the predictions of ΛCDM halos, and find that given current uncertainties in the host halo properties of SDP.81, our measurements of substructure are consistent with theoretical expectations. Finally, observations of larger samples of gravitational lenses with ALMA should be able to improve the constraints on the abundance of galactic substructure.« less

DETECTION OF LENSING SUBSTRUCTURE USING ALMA OBSERVATIONS OF THE DUSTY GALAXY SDP.81

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hezaveh, Yashar D.; Mao, Yao-Yuan; Morningstar, Warren

2016-05-20

We study the abundance of substructure in the matter density near galaxies using ALMA Science Verification observations of the strong lensing system SDP.81. We present a method to measure the abundance of subhalos around galaxies using interferometric observations of gravitational lenses. Using simulated ALMA observations we explore the effects of various systematics, including antenna phase errors and source priors, and show how such errors may be measured or marginalized. We apply our formalism to ALMA observations of SDP.81. We find evidence for the presence of a M = 10{sup 8.96±0.12} M {sub ⊙} subhalo near one of the images, withmore » a significance of 6.9 σ in a joint fit to data from bands 6 and 7; the effect of the subhalo is also detected in both bands individually. We also derive constraints on the abundance of dark matter (DM) subhalos down to M ∼ 2 × 10{sup 7} M {sub ⊙}, pushing down to the mass regime of the smallest detected satellites in the Local Group, where there are significant discrepancies between the observed population of luminous galaxies and predicted DM subhalos. We find hints of additional substructure, warranting further study using the full SDP.81 data set (including, for example, the spectroscopic imaging of the lensed carbon monoxide emission). We compare the results of this search to the predictions of ΛCDM halos, and find that given current uncertainties in the host halo properties of SDP.81, our measurements of substructure are consistent with theoretical expectations. Observations of larger samples of gravitational lenses with ALMA should be able to improve the constraints on the abundance of galactic substructure.« less

Synthetic diagnostics platform for fusion plasmas (invited)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shi, L.; Valeo, E. J.; Tobias, B. J.

A Synthetic Diagnostics Platform (SDP) for fusion plasmas has been developed which provides state of the art synthetic reflectometry, beam emission spectroscopy, and Electron Cyclotron Emission (ECE) diagnostics. Interfaces to the plasma simulation codes GTC, XGC-1, GTS, and M3D-C-1 are provided, enabling detailed validation of these codes. In this paper, we give an overview of SDP's capabilities, and introduce the synthetic diagnostic modules. A recently developed synthetic ECE Imaging module which self-consistently includes refraction, diffraction, emission, and absorption effects is discussed in detail. Its capabilities are demonstrated on two model plasmas. Finally, the importance of synthetic diagnostics in validation ismore » shown by applying the SDP to M3D-C 1 output and comparing it with measurements from an edge harmonic oscillation mode on DIII-D.« less

Synthetic diagnostics platform for fusion plasmas (invited)

DOE PAGES

Shi, L.; Valeo, E. J.; Tobias, B. J.; ...

2016-08-26

A Synthetic Diagnostics Platform (SDP) for fusion plasmas has been developed which provides state of the art synthetic reflectometry, beam emission spectroscopy, and Electron Cyclotron Emission (ECE) diagnostics. Interfaces to the plasma simulation codes GTC, XGC-1, GTS, and M3D-C-1 are provided, enabling detailed validation of these codes. In this paper, we give an overview of SDP's capabilities, and introduce the synthetic diagnostic modules. A recently developed synthetic ECE Imaging module which self-consistently includes refraction, diffraction, emission, and absorption effects is discussed in detail. Its capabilities are demonstrated on two model plasmas. Finally, the importance of synthetic diagnostics in validation ismore » shown by applying the SDP to M3D-C 1 output and comparing it with measurements from an edge harmonic oscillation mode on DIII-D.« less

The impact of gestational diabetes and hypothyroidism on the third-trimester ultrasound parameters and in adverse perinatal outcomes: a retrospective cohort study.

PubMed

Peixoto, Alberto Borges; Caldas, Taciana Mara Rodrigues da Cunha; Santos, Raisa Oliveira; Lopes, Karina Souza; Martins, Wellington P; Araujo Júnior, Edward

2016-11-01

To assess the impact of gestational diabetes and hypothyroidism on the third-trimester ultrasound parameters and in adverse perinatal outcomes. We performed a retrospective cohort study with 817 singleton pregnant women between 26w0d and 37w6d of gestation which were divided in four groups: 56 gestational diabetes mellitus (GDM), 63 hypothyroidism, 14 GDM + hypothyroidism, and 684 controls. The following ultrasound parameters were assessed: mean uterine artery pulsatility index (PI), umbilical artery PI, middle cerebral artery PI, single deepest pocket (SDP) and cerebroplacental ratio (CPR). Adverse perinatal outcomes were the following: low birth weight, macrosomia, and Agar score at 1st min <7. These four groups were compared using the Kruskall-Wallis and χ(2) tests. Pregnant women from GDM showed higher weight (p < 0.001), BMI (p < 0.001), SDP (p < 0.001) and newborns with higher birth weight (p = 0.008) and macrosomia (p = 0.02) than other groups. Comparing with control, hypothyroidism showed higher SDP (p < 0.05). Pregnant women with GDM showed higher risk of macrosomic newborns than other three groups. Both pregnant women with GDM and hypothyroidism showed higher SDP than normal pregnancies.

Water resources planning and management : A stochastic dual dynamic programming approach

NASA Astrophysics Data System (ADS)

Goor, Q.; Pinte, D.; Tilmant, A.

2008-12-01

Allocating water between different users and uses, including the environment, is one of the most challenging task facing water resources managers and has always been at the heart of Integrated Water Resources Management (IWRM). As water scarcity is expected to increase over time, allocation decisions among the different uses will have to be found taking into account the complex interactions between water and the economy. Hydro-economic optimization models can capture those interactions while prescribing efficient allocation policies. Many hydro-economic models found in the literature are formulated as large-scale non linear optimization problems (NLP), seeking to maximize net benefits from the system operation while meeting operational and/or institutional constraints, and describing the main hydrological processes. However, those models rarely incorporate the uncertainty inherent to the availability of water, essentially because of the computational difficulties associated stochastic formulations. The purpose of this presentation is to present a stochastic programming model that can identify economically efficient allocation policies in large-scale multipurpose multireservoir systems. The model is based on stochastic dual dynamic programming (SDDP), an extension of traditional SDP that is not affected by the curse of dimensionality. SDDP identify efficient allocation policies while considering the hydrologic uncertainty. The objective function includes the net benefits from the hydropower and irrigation sectors, as well as penalties for not meeting operational and/or institutional constraints. To be able to implement the efficient decomposition scheme that remove the computational burden, the one-stage SDDP problem has to be a linear program. Recent developments improve the representation of the non-linear and mildly non- convex hydropower function through a convex hull approximation of the true hydropower function. This model is illustrated on a cascade of 14 reservoirs on the Nile river basin.

Safety of spray-dried powder formulated Pseudomonas fluorescens strain CL145A exposure to subadult/adult unionid mussels during simulated open-water treatments

USGS Publications Warehouse

Luoma, James A.; Weber, Kerry L.; Waller, Diane L.; Wise, Jeremy K.; Mayer, Denise A.; Aloisi, Douglas B.

2015-01-01

After exposure, the mussels were consolidated into wire mesh cages and placed in the Black River for a 27-28 day postexposure period, after which time survival of mussels was assessed. Of the 1,170 mussels tested in the study, 3 were confirmed dead and 5 were not recovered and treated as mortalities in the analysis. The effect and interactions of species, SDP exposure concentration, and SDP exposure duration were analyzed and did not affect mussel survival (p > 0.98). The results from this study indicate that SDP exposure at the maximum approved open-water concentration of 100 mg/L for up to 3 times the maximum approved open-water exposure duration of 8 hours (in other words for 24 hours of exposure) is unlikely to reduce survival of subadult or adult mussels.

Medium Duty Electric Vehicle Demonstration Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mackie, Robin J. D.

2015-05-31

The Smith Electric Vehicle Demonstration Project (SDP) was integral to the Smith business plan to establish a manufacturing base in the United States (US) and produce a portfolio of All Electric Vehicles (AEV’s) for the medium duty commercial truck market. Smith focused on the commercial depot based logistics market, as it represented the market that was most ready for the early adoption of AEV technology. The SDP enabled Smith to accelerate its introduction of vehicles and increase the size of its US supply chain to support early market adoption of AEV’s that were cost competitive, fully met the needs ofmore » a diverse set of end users and were compliant with Federal safety and emissions requirements. The SDP accelerated the development and production of various electric drive vehicle systems to substantially reduce petroleum consumption, reduce vehicular emissions of greenhouse gases (GHG), and increase US jobs.« less

DC and AC Electric Field Measurements by Spin-Plane Double Probes Onboard MMS

NASA Astrophysics Data System (ADS)

Lindqvist, P. A.; Marklund, G. T.; Khotyaintsev, Y. V.; Ergun, R. E.; Goodrich, K.; Torbert, R. B.; Argall, M. R.; Nakamura, R.

2015-12-01

The four spacecraft of the NASA Magnetospheric Multiscale mission (MMS) were launched on 12 March 2015 into a 1.2 x 12 Re equatorial orbit to study energy conversion processes in Earth's magnetosphere. After a 5-month commissioning period the first scientific phase starts on 1 September as the orbit enters the dusk magnetopause region. The Spin-plane Double Probe electric field instrument (SDP), part of the electric and magnetic fields instrument suite FIELDS, measures the electric field in the range 0.3 - 500 mV/m with a continuous time resolution up to 8192 samples/s. The instrument features adjustable bias currents and guard voltages to optimize the measurement performance. SDP also measures the spacecraft potential, which can be controlled by the Active Spacecraft Potential Control (ASPOC) ion emitter, and under certain conditions can be used to determine plasma density. We present observations of DC and AC electric fields in different plasma regions covered by MMS since launch including the night side flow braking region, reconnection regions at the dusk and dayside magnetopause, and in the magnetosheath. We compare the electric field measurements by SDP to other, independent determinations of the electric field, in particular by the Electron Drift Instrument (EDI), in order to assess the accuracy of the electric field measurement under different plasma conditions. We also study the influence of the currents emitted by ASPOC and EDI on the SDP measurements.

Lightweight SIP/SDP compression scheme (LSSCS)

NASA Astrophysics Data System (ADS)

Wu, Jian J.; Demetrescu, Cristian

2001-10-01

In UMTS new IP based services with tight delay constraints will be deployed over the W-CDMA air interface such as IP multimedia and interactive services. To integrate the wireline and wireless IP services, 3GPP standard forum adopted the Session Initiation Protocol (SIP) as the call control protocol for the UMTS Release 5, which will implement next generation, all IP networks for real-time QoS services. In the current form the SIP protocol is not suitable for wireless transmission due to its large message size which will need either a big radio pipe for transmission or it will take far much longer to transmit than the current GSM Call Control (CC) message sequence. In this paper we present a novel compression algorithm called Lightweight SIP/SDP Compression Scheme (LSSCS), which acts at the SIP application layer and therefore removes the information redundancy before it is sent to the network and transport layer. A binary octet-aligned header is added to the compressed SIP/SDP message before sending it to the network layer. The receiver uses this binary header as well as the pre-cached information to regenerate the original SIP/SDP message. The key features of the LSSCS compression scheme are presented in this paper along with implementation examples. It is shown that this compression algorithm makes SIP transmission efficient over the radio interface without losing the SIP generality and flexibility.

An Electroencephalography Network and Connectivity Analysis for Deception in Instructed Lying Tasks

PubMed Central

Wang, Yue; Ng, Wu Chun; Ng, Khoon Siong; Yu, Ke; Wu, Tiecheng; Li, Xiaoping

2015-01-01

Deception is an impactful social event that has been the focus of an abundance of researches over recent decades. In this paper, an electroencephalography (EEG) study is presented regarding the cognitive processes of an instructed liar/truth-teller during the time window of stimulus (question) delivery period (SDP) prior to their deceptive/truthful responses towards questions related to authentic (WE: with prior experience) and fictional experience (NE: no prior experience). To investigate deception in non-experienced events, the subjects were given stimuli in a mock interview scenario that induced them to fabricate lies. To analyze the data, frequency domain network and connectivity analysis was performed in the source space in order to provide a more systematic level understanding of deception during SDP. This study reveals several groups of neuronal generators underlying both the instructed lying (IL) and the instructed truth-telling (IT) conditions for both tasks during the SDP. Despite the similarities existed in these group components, significant differences were found in the intra- and inter-group connectivity between the IL and IT conditions in either task. Additionally, the response time was found to be positively correlated with the clustering coefficient of the inferior frontal gyrus (44R) in the WE-IL condition and positively correlated with the clustering coefficient of the precuneus (7L) and the angular gyrus (39R) in the WE-IT condition. However, the response time was found to be marginally negatively correlated with the clustering coefficient of the secondary auditory cortex (42L) in the NE-IL condition and negatively correlated with the clustering coefficient of the somatosensory association cortex (5L, R) in the NE-IT condition. Therefore, these results provide complementary and intuitive evidence for the differences between the IL and IT conditions in SDP for two types of deception tasks, thus elucidating the electrophysiological mechanisms underlying SDP of deception from regional, inter-regional, network, and inter-network scale analyses. PMID:25679784

Asymmetry and coherence weight of quantum states

NASA Astrophysics Data System (ADS)

Bu, Kaifeng; Anand, Namit; Singh, Uttam

2018-03-01

The asymmetry of quantum states is an important resource in quantum information processing tasks such as quantum metrology and quantum communication. In this paper, we introduce the notion of asymmetry weight—an operationally motivated asymmetry quantifier in the resource theory of asymmetry. We study the convexity and monotonicity properties of asymmetry weight and focus on its interplay with the corresponding semidefinite programming (SDP) forms along with its connection to other asymmetry measures. Since the SDP form of asymmetry weight is closely related to asymmetry witnesses, we find that the asymmetry weight can be regarded as a (state-dependent) asymmetry witness. Moreover, some specific entanglement witnesses can be viewed as a special case of an asymmetry witness—which indicates a potential connection between asymmetry and entanglement. We also provide an operationally meaningful coherence measure, which we term coherence weight, and investigate its relationship to other coherence measures like the robustness of coherence and the l1 norm of coherence. In particular, we show that for Werner states in any dimension d all three coherence quantifiers, namely, the coherence weight, the robustness of coherence, and the l1 norm of coherence, are equal and are given by a single letter formula.

Exposure-related effects of Pseudomonas fluorescens, strain CL145A, on coldwater, coolwater, and warmwater fish

USGS Publications Warehouse

Luoma, James A.; Weber, Kerry L.; Denise A. Mayer,

2015-01-01

Further investigations to evaluate the SDP-exposure related effects on freshwater fish at the maximum approved open-water label concentration and exposure duration (100 mg/L for 8 hours) and using the expected lentic application technique (static application) are warranted. The variation in tolerance to P. fluorescens, strain CL145A, exposure observed in this study indicates that fish species community composition should be considered before SDP is applied in open-water environments.

Strategic Distribution Platform Support of CONUS Army Units

DTIC Science & Technology

2011-01-01

agreed to the goal that the SDP will be the source for 85 percent of customer demands stocked in DLA depots. • Leverage high fill rates via scheduled...goal that the SDP will be the source for 85 percent of customer demands stocked in DLA depots (called the “facing fill” or “gross fill rate” metric...RWT metric does not include time spent in backorder status (i.e., no stock was available to ship). 6 The increase in 2003 and into 2004 in the figure

Sync-rank: Robust Ranking, Constrained Ranking and Rank Aggregation via Eigenvector and SDP Synchronization

DTIC Science & Technology

2015-04-28

the players . In addition, we compare the algorithms on three real data sets: the outcome of soccer games in the English Premier League, a Microsoft...Premier League soccer games, a Halo 2 game tournament and NCAA College Basketball games), which show that our proposed method compares favorably to...information on the ground truth rank of a subset of players , and propose an algorithm based on SDP which is able to recover the ranking of the remaining

Experience gained with the Synroc demonstration plant at ANSTO and its relevance to plutonium immobilization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jostsons, A.; Ridal, A.; Mercer, D.J.

1996-05-01

The Synroc Demonstration Plant (SDP) was designed and constructed at Lucas Heights to demonstrate the feasibility of Synroc production on a commercial scale (10 kg/hr) with simulated Purex liquid HLW. Since commissioning of the SDP in 1987, over 6000 kg of Synroc has been fabricated with a range of feeds and waste loadings. The SDP utilises uniaxial hot-pressing to consolidate Synroc. Pressureless sintering and hot-isostatic pressing have also been studied at smaller scales. The results of this extensive process development have been incorporated in a conceptual design for a radioactive plant to condition HLW from a reprocessing plant with amore » capacity to treat 800 tpa of spent LWR fuel. Synroic containing TRU, including Pu, and fission products has been fabricated and characterised in a glove-box facility and hot cells, respectively. The extensive experience in processing of Synroc over the past 15 years is summarised and its relevance to immobilization of surplus plutonium is discussed.« less

Questioning the causal link between maternal smoking during pregnancy and offspring use of psychotropic medication: a sibling design analysis.

PubMed

Söderström, Lovisa; Perez-Vicente, Raquel; Juárez, Sol; Merlo, Juan

2013-01-01

A recent population-based, longitudinal study from Finland observed a dose-response association between smoking during pregnancy (SDP) and use of psychotropic medications in exposed children and young adults. However, this association may be confounded by unmeasured familial characteristics related to both SDP and offspring mental health. Consequently, we aim to investigate the effect of SDP by means of a sibling design that to some extent allows controlling for unknown environmental and genetic confounders. Using the Swedish Medical Birth Register (1987-1993), which was linked to the Swedish Prescribed Drugs Register (July 2005-December 2008), we investigated 579,543 children and among them 39, 007 were discordant for use of psychotropic medication and 4,021 siblings discordant for both use of psychotropic medication and for smoking exposure. Replicating the Finnish study using traditional logistic regression methods we found an association between exposure to ≥10 cigarettes per day during pregnancy and psychotropic drug use (odds ratio = 1.61, 95% confidence interval 1.56, 1.66). Similar in size to the association reported from Finland (odds ratio = 1.63; 95% confidence interval 1.53, 1.74). However, in the adjusted sibling analysis using conditional logistic regression, the association was considerably reduced (odds ratio 1.22; 95% confidence interval 1.08, 1.38). Preventing smoking is of major public health importance. However, SDP per se appears to have less influence on offspring psychotropic drug use than previously suggested.

Comparative Model Tests of SDP and CFA Pile Groups in Non-Cohesive Soil

NASA Astrophysics Data System (ADS)

Krasiński, Adam; Kusio, Tomasz

2015-02-01

The research topic relates to the subject of deep foundations supported on continuous flight auger (CFA) piles and screw displacement piles (SDP). The authors have decided to conduct model tests of foundations supported on the group of piles mentioned above and also the tests of the same piles working as a single. The tests are ongoing in Geotechnical Laboratory of Gdaňsk University of Technology. The description of test procedure, interpretation and analysis of the preliminary testing series results are presented in the paper.

Enhanced triacylglycerol accumulation in vegetative tissues of plants

DOEpatents

Xu, Changcheng; Fan, Jilian; Yan, Chengshi; Shanklin, John

2017-03-14

In the tgd1-1 mutant that displays substantially enhanced TAG synthesis and turnover, disruption of SUGAR-DEPENDENT1 (SDP1) TAG lipase or PEROXISOMAL TRANSPORTER1 (PXA1) severely decreases FA turnover, leading to an increase in leaf TAG content up to 9% of dry weight and total leaf lipid by three-fold. The membrane lipid content and composition of tgd1-1 sdp1-4 and tgd1-1 pxa1-2 double mutants are altered and they are compromised in growth and development and fertility.

Phase II modification of the Water Availability Tool for Environmental Resources (WATER) for Kentucky: The sinkhole-drainage process, point-and-click basin delineation, and results of karst test-basin simulations

USGS Publications Warehouse

Taylor, Charles J.; Williamson, Tanja N.; Newson, Jeremy K.; Ulery, Randy L.; Nelson, Hugh L.; Cinotto, Peter J.

2012-01-01

This report describes Phase II modifications made to the Water Availability Tool for Environmental Resources (WATER), which applies the process-based TOPMODEL approach to simulate or predict stream discharge in surface basins in the Commonwealth of Kentucky. The previous (Phase I) version of WATER did not provide a means of identifying sinkhole catchments or accounting for the effects of karst (internal) drainage in a TOPMODEL-simulated basin. In the Phase II version of WATER, sinkhole catchments are automatically identified and delineated as internally drained subbasins, and a modified TOPMODEL approach (called the sinkhole drainage process, or SDP-TOPMODEL) is applied that calculates mean daily discharges for the basin based on summed area-weighted contributions from sinkhole drain-age (SD) areas and non-karstic topographically drained (TD) areas. Results obtained using the SDP-TOPMODEL approach were evaluated for 12 karst test basins located in each of the major karst terrains in Kentucky. Visual comparison of simulated hydrographs and flow-duration curves, along with statistical measures applied to the simulated discharge data (bias, correlation, root mean square error, and Nash-Sutcliffe efficiency coefficients), indicate that the SDPOPMODEL approach provides acceptably accurate estimates of discharge for most flow conditions and typically provides more accurate simulation of stream discharge in karstic basins compared to the standard TOPMODEL approach. Additional programming modifications made to the Phase II version of WATER included implementation of a point-and-click graphical user interface (GUI), which fully automates the delineation of simulation-basin boundaries and improves the speed of input-data processing. The Phase II version of WATER enables the user to select a pour point anywhere on a stream reach of interest, and the program will automatically delineate all upstream areas that contribute drainage to that point. This capability enables automatic delineation of a simulation basin of any size (area) and having any level of stream-network complexity. WATER then automatically identifies the presence of sinkholes catchments within the simulation basin boundaries; extracts and compiles the necessary climatic, topographic, and basin characteristics datasets; and runs the SDP-TOPMODEL approach to estimate daily mean discharges (streamflow).

Clinical application of RT-nested PCR integrated with RFLP in Hantavirus detection and genotyping: a prospective study in Shandong Province, PR China.

PubMed

Liu, Yun-Xi; Zhao, Zhong-Tang; Cao, Wu-Chun; Xu, Xiao-Qun; Suo, Ji-Jiang; Xing, Yu-Bin; Jia, Ning; Du, Ming-Mei; Liu, Bo-Wei; Yao, Yuan

2013-01-01

The aim of the present study was to evaluate the clinical usefulness of applying RT-nested PCR along with RFLP as a method for diagnosis and genotypic differentiation of Hantavirus in the acute-stage sera of HFRS patients as compared to the ELISA technique. A prospective study of patients with suspected HFRS patients was carried out. Sera were collected for serological evaluation by ELISA and RT-nested PCR testing. Primers were selected from the published sequence of the S segment of HTNV strain 76-118 and SEOV strain SR-11, which made it possible to obtain an amplicon of 403 bp by RT-nested PCR. The genotypic differentiations of the RT-nested PCR amplicons were carried out by RFLP. Sequence analyses of the amplicons were used to confirm the accuracy of the results obtained by RFLP. Of the 48 acute-stage sera from suspected HFRS patients, 35 were ELISA-positive while 41 were positive by RT-nested PCR. With Hind III and Hinf I, RFLP profiles of the RT-nested PCR amplicons of the 41 positive sera exhibited two patterns. 33 had RFLP profiles similar to the reference strain R22, and thus belonged to the SEOV type. The other 8 samples which were collected during October-December had RFLP profiles similar to the reference strain 76-118, and thus belonged to the HTNV type. Sequence phylogenetic analysis of RT-nested PCR amplicons revealed sdp1, sdp2 YXL-2008, and sdp3 as close relatives of HTNV strain 76-118, while sdp22 and sdp37 as close relatives of SEOV strain Z37 and strain R22 located in two separate clusters in the phylogenetic tree. These results were identical to those acquired by RFLP. RT-nested PCR integrated with RFLP was a rapid, simple, accurate method for detecting and differentiating the genotypes of Hantavirus in the acute-stage sera of suspected HFRS patients. In Shandong province, the main genotypes of Hantavirus belonged to the SEOV types, while the HTNV types were observed during the autumn-winter season.

Implementing shared decision-making in routine practice: barriers and opportunities.

PubMed

Holmes-Rovner, Margaret; Valade, Diane; Orlowski, Catherine; Draus, Catherine; Nabozny-Valerio, Barbara; Keiser, Susan

2000-09-01

OBJECTIVE: Determine feasibility of shared decision-making programmes in fee-for-service hospital systems including physicians' offices and in-patient facilities. DESIGN: Survey and participant observation. Data obtained during Phase 1 of a patient outcome study. SETTINGS AND PARTICIPANTS: Three hospitals in Michigan: one 299-bed rural regional hospital, one 650-bed urban community hospital, one 459-bed urban and suburban teaching hospital. All nurses and physicians who agreed to use the programmes participated in the evaluation (n = 34). INTERVENTION: Two shared decision-making(R) (SDP) multimedia programmes: surgical treatment choice for breast cancer and ischaemic heart disease treatment choice. MAIN OUTCOME MEASURES: (1) clinicians' evaluations of programme quality; (2) challenges in hospital settings; and (3) patient referral rates. RESULTS: SDP programmes were judged to be clear, accurate and about the right length and amount of information. Programmes were judged to be informative and appropriate for patients to see before making a decision. Clinicians were neutral about patients' desire to participate in treatment decision-making. Referral volume to SDPs was lower than expected: 24 patients in 7 months across three hospitals. Implementation challenges centred on time pressures in patient care. CONCLUSIONS: Productivity and time pressure in US health care severely constrain shared decision-making programme implementation. Physician referral may not be a reliable mechanism for patient access. Possible innovations include: (1) incorporation into the informed consent process; (2) provider or payer negotiated requirement in the routine hospital procedure to use the SDP as a quality indicator; and (3) payer reimbursement to professional providers who make SDP programmes available to patients.

High-resolution Observations of Hα Spectra with a Subtractive Double Pass

NASA Astrophysics Data System (ADS)

Beck, C.; Rezaei, R.; Choudhary, D. P.; Gosain, S.; Tritschler, A.; Louis, R. E.

2018-02-01

High-resolution imaging spectroscopy in solar physics has relied on Fabry-Pérot interferometers (FPIs) in recent years. FPI systems, however, become technically challenging and expensive for telescopes larger than the 1 m class. A conventional slit spectrograph with a diffraction-limited performance over a large field of view (FOV) can be built at much lower cost and effort. It can be converted into an imaging spectro(polari)meter using the concept of a subtractive double pass (SDP). We demonstrate that an SDP system can reach a similar performance as FPI-based systems with a high spatial and moderate spectral resolution across a FOV of 100^'' ×100^' ' with a spectral coverage of 1 nm. We use Hα spectra taken with an SDP system at the Dunn Solar Telescope and complementary full-disc data to infer the properties of small-scale superpenumbral filaments. We find that the majority of all filaments end in patches of opposite-polarity fields. The internal fine-structure in the line-core intensity of Hα at spatial scales of about 0.5'' exceeds that in other parameters such as the line width, indicating small-scale opacity effects in a larger-scale structure with common properties. We conclude that SDP systems in combination with (multi-conjugate) adaptive optics are a valid alternative to FPI systems when high spatial resolution and a large FOV are required. They can also reach a cadence that is comparable to that of FPI systems, while providing a much larger spectral range and a simultaneous multi-line capability.

A Central Role for Triacylglycerol in Membrane Lipid Breakdown, Fatty Acid β-Oxidation, and Plant Survival under Extended Darkness1[OPEN

PubMed Central

2017-01-01

Neutral lipid metabolism is a key aspect of intracellular homeostasis and energy balance and plays a vital role in cell survival under adverse conditions, including nutrient deprivation in yeast and mammals, but the role of triacylglycerol (TAG) metabolism in plant stress response remains largely unknown. By thoroughly characterizing mutants defective in SUGAR-DEPENDENT1 (SDP1) triacylglycerol lipase or PEROXISOMAL ABC TRANSPORTER 1 (PXA1), here we show that TAG is a key intermediate in the mobilization of fatty acids from membrane lipids for peroxisomal β-oxidation under prolonged dark treatment. Disruption of SDP1 increased TAG accumulation in cytosolic lipid droplets and markedly enhanced plant tolerance to extended darkness. We demonstrate that blocking TAG hydrolysis enhances plant tolerance to dark treatment via two distinct mechanisms. In pxa1 mutants, in which free fatty acids accumulated rapidly under extended darkness, SDP1 disruption resulted in a marked decrease in levels of cytotoxic lipid intermediates such as free fatty acids and phosphatidic acid, suggesting a buffer function of TAG accumulation against lipotoxicity under fatty acid overload. In the wild type, in which free fatty acids remained low and unchanged under dark treatment, disruption of SDP1 caused a decrease in reactive oxygen species production and hence the level of lipid peroxidation, indicating a role of TAG in protection against oxidative damage. Overall, our findings reveal a crucial role for TAG metabolism in membrane lipid breakdown, fatty acid turnover, and plant survival under extended darkness. PMID:28572457

Dimensions of disinhibited personality and their relation with alcohol use and problems

PubMed Central

Gunn, Rachel L.; Finn, Peter R.; Endres, Michael J.; Gerst, Kyle R.; Spinola, Suzanne

2013-01-01

Although alcohol use disorders (AUDs) have been associated with different aspects of disinhibited personality and antisociality, less is known about the specific relationships among different domains of disinhibited personality, antisociality, alcohol use, and alcohol problems. The current study was designed to address three goals, (i) to provide evidence of a three-factor model of disinhibited personality (comprised of impulsivity [IMP], risk taking/ low harm avoidance [RTHA], excitement seeking [ES]), (ii) to test hypotheses regarding the association between each dimension and alcohol use and problems, and (iii) to test the hypothesis that antisociality (social deviance proneness [SDP]) accounts for the direct association between IMP and alcohol problems, while ES is directly related to alcohol use. Measures of disinhibited personality IMP, RTHA, ES and SDP and alcohol use and problems were assessed in a sample of young adults (N=474), which included a high proportion of individuals with AUDs. Confirmatory factor analyses supported a three-factor model of disinhibited personality reflecting IMP, RTHA, and ES. A structural equation model (SEM) showed that IMP was specifically associated with alcohol problems, while ES was specifically associated with alcohol use. In a second SEM, SDP accounted for the majority of the variance in alcohol problems associated with IMP. The results suggest aspects of IMP associated with SDP represent a direct vulnerability to alcohol problems. In addition, the results suggest that ES reflects a specific vulnerability to excessive alcohol use, which is then associated with alcohol problems, while RTHA is not specifically associated with alcohol use or problems when controlling for IMP and ES. PMID:23588138

A Central Role for Triacylglycerol in Membrane Lipid Breakdown, Fatty Acid β-Oxidation, and Plant Survival under Extended Darkness.

PubMed

Fan, Jilian; Yu, Linhui; Xu, Changcheng

2017-07-01

Neutral lipid metabolism is a key aspect of intracellular homeostasis and energy balance and plays a vital role in cell survival under adverse conditions, including nutrient deprivation in yeast and mammals, but the role of triacylglycerol (TAG) metabolism in plant stress response remains largely unknown. By thoroughly characterizing mutants defective in SUGAR-DEPENDENT1 (SDP1) triacylglycerol lipase or PEROXISOMAL ABC TRANSPORTER 1 (PXA1), here we show that TAG is a key intermediate in the mobilization of fatty acids from membrane lipids for peroxisomal β-oxidation under prolonged dark treatment. Disruption of SDP1 increased TAG accumulation in cytosolic lipid droplets and markedly enhanced plant tolerance to extended darkness. We demonstrate that blocking TAG hydrolysis enhances plant tolerance to dark treatment via two distinct mechanisms. In pxa1 mutants, in which free fatty acids accumulated rapidly under extended darkness, SDP1 disruption resulted in a marked decrease in levels of cytotoxic lipid intermediates such as free fatty acids and phosphatidic acid, suggesting a buffer function of TAG accumulation against lipotoxicity under fatty acid overload. In the wild type, in which free fatty acids remained low and unchanged under dark treatment, disruption of SDP1 caused a decrease in reactive oxygen species production and hence the level of lipid peroxidation, indicating a role of TAG in protection against oxidative damage. Overall, our findings reveal a crucial role for TAG metabolism in membrane lipid breakdown, fatty acid turnover, and plant survival under extended darkness. © 2017 American Society of Plant Biologists. All Rights Reserved.

Variational calculation of second-order reduced density matrices by strong N-representability conditions and an accurate semidefinite programming solver.

PubMed

Nakata, Maho; Braams, Bastiaan J; Fujisawa, Katsuki; Fukuda, Mituhiro; Percus, Jerome K; Yamashita, Makoto; Zhao, Zhengji

2008-04-28

The reduced density matrix (RDM) method, which is a variational calculation based on the second-order reduced density matrix, is applied to the ground state energies and the dipole moments for 57 different states of atoms, molecules, and to the ground state energies and the elements of 2-RDM for the Hubbard model. We explore the well-known N-representability conditions (P, Q, and G) together with the more recent and much stronger T1 and T2(') conditions. T2(') condition was recently rederived and it implies T2 condition. Using these N-representability conditions, we can usually calculate correlation energies in percentage ranging from 100% to 101%, whose accuracy is similar to CCSD(T) and even better for high spin states or anion systems where CCSD(T) fails. Highly accurate calculations are carried out by handling equality constraints and/or developing multiple precision arithmetic in the semidefinite programming (SDP) solver. Results show that handling equality constraints correctly improves the accuracy from 0.1 to 0.6 mhartree. Additionally, improvements by replacing T2 condition with T2(') condition are typically of 0.1-0.5 mhartree. The newly developed multiple precision arithmetic version of SDP solver calculates extraordinary accurate energies for the one dimensional Hubbard model and Be atom. It gives at least 16 significant digits for energies, where double precision calculations gives only two to eight digits. It also provides physically meaningful results for the Hubbard model in the high correlation limit.

Dietary Animal Plasma Proteins Improve the Intestinal Immune Response in Senescent Mice.

PubMed

Miró, Lluïsa; Garcia-Just, Alba; Amat, Concepció; Polo, Javier; Moretó, Miquel; Pérez-Bosque, Anna

2017-12-11

Increased life expectancy has promoted research on healthy aging. Aging is accompanied by increased non-specific immune activation (inflammaging) which favors the appearance of several disorders. Here, we study whether dietary supplementation with spray-dried animal plasma (SDP), which has been shown to reduce the activation of gut-associated lymphoid tissue (GALT) in rodents challenged by S. aureus enterotoxin B (SEB), and can also prevent the effects of aging on immune system homeostasis. We first characterized GALT in a mouse model of accelerated senescence (SAMP8) at different ages (compared to mice resistant to accelerated senescence; SAMR1). Second, we analyzed the SDP effects on GALT response to an SEB challenge in SAMP8 mice. In GALT characterization, aging increased the cell number and the percentage of activated Th lymphocytes in mesenteric lymph nodes and Peyer's patches (all, p < 0.05), as well as the expression of IL-6 and TNF-α in intestinal mucosa (both, p < 0.05). With respect to GALT response to the SEB challenge, young mice showed increased expression of intestinal IL-6 and TNF-α, as well as lymphocyte recruitment and activation (all, p < 0.05). However, the immune response of senescent mice to the SEB challenge was weak, since SEB did not change cell recruitment or the percentage of activated Th lymphocytes. Mice supplemented with SDP showed improved capacity to respond to the SEB challenge, similar to the response of the young mice. These results indicate that senescent mice have an impaired mucosal immune response characterized by unspecific GALT activation and a weak specific immune response. SDP supplementation reduces non-specific basal immune activation, allowing for the generation of specific responses.

OMNIgene.SPUTUM suppresses contaminants while maintaining Mycobacterium tuberculosis viability and obviates cold-chain transport.

PubMed

Azam, Khalide; Cadir, Nureisha; Madeira, Carla; Gillespie, Stephen H; Sabiiti, Wilber

2018-01-01

Tuberculosis (TB) diagnostics are centralised, requiring long-distance transportation of specimens in most resource-limited settings. We evaluated the ability of OMNIgene.SPUTUM (OM-S) to obviate cold-chain transport of TB specimens. A two-arm (same-day and after 5 days sample processing) study was conducted to assess contamination rates and Mycobacterium tuberculosis viability in OM-S-treated samples against the standard decontamination procedure (SDP) in Mozambique, using Lowenstein Jensen (LJ) and mycobacterial growth indicator tube (MGIT) culture and molecular bacterial load assay. 270 specimens were processed using OM-S and SDP in same-day and 5-day arms. Contamination was lower in OM-S-treated than SDP-treated cultures: 12% versus 15% and 2% versus 27% in the same-day and 5-day arms, respectively. M. tuberculosis recovery in OM-S-treated LJ cultures was 10% and 56% higher in the same-day and 5-day arms, respectively, than SDP-treated cultures, but lower in MGIT (52% and 28% lower in the same-day and 5-day arms, respectively). M. tuberculosis viable count was 1log estimated CFU·mL -1 lower in 5-day OM-S-treated sputa. OM-S was more effective at liquefying sputum with a shorter sample processing time: 22 min for culture. OM-S is simple to use and has demonstrated a high potency to suppress contaminants, maintenance of viability at ambient temperatures and higher M. tuberculosis recovery, particularly in the solid LJ cultures. Optimisation of OM-S to achieve higher MGIT culture positivity and shorter time to result will increase its application and utility in the clinical management of TB.

OMNIgene.SPUTUM suppresses contaminants while maintaining Mycobacterium tuberculosis viability and obviates cold-chain transport

PubMed Central

Azam, Khalide; Cadir, Nureisha; Madeira, Carla; Gillespie, Stephen H.; Sabiiti, Wilber

2018-01-01

Tuberculosis (TB) diagnostics are centralised, requiring long-distance transportation of specimens in most resource-limited settings. We evaluated the ability of OMNIgene.SPUTUM (OM-S) to obviate cold-chain transport of TB specimens. A two-arm (same-day and after 5 days sample processing) study was conducted to assess contamination rates and Mycobacterium tuberculosis viability in OM-S-treated samples against the standard decontamination procedure (SDP) in Mozambique, using Lowenstein Jensen (LJ) and mycobacterial growth indicator tube (MGIT) culture and molecular bacterial load assay. 270 specimens were processed using OM-S and SDP in same-day and 5-day arms. Contamination was lower in OM-S-treated than SDP-treated cultures: 12% versus 15% and 2% versus 27% in the same-day and 5-day arms, respectively. M. tuberculosis recovery in OM-S-treated LJ cultures was 10% and 56% higher in the same-day and 5-day arms, respectively, than SDP-treated cultures, but lower in MGIT (52% and 28% lower in the same-day and 5-day arms, respectively). M. tuberculosis viable count was 1log estimated CFU·mL−1 lower in 5-day OM-S-treated sputa. OM-S was more effective at liquefying sputum with a shorter sample processing time: 22 min for culture. OM-S is simple to use and has demonstrated a high potency to suppress contaminants, maintenance of viability at ambient temperatures and higher M. tuberculosis recovery, particularly in the solid LJ cultures. Optimisation of OM-S to achieve higher MGIT culture positivity and shorter time to result will increase its application and utility in the clinical management of TB. PMID:29479537

Radionuclide bone scan SPECT-CT: lowering the dose of CT significantly reduces radiation dose without impacting CT image quality

PubMed Central

Gupta, Sandeep Kumar; Trethewey, Scott; Brooker, Bree; Rutherford, Natalie; Diffey, Jenny; Viswanathan, Suresh; Attia, John

2017-01-01

The CT component of SPECT-CT is required for attenuation correction and anatomical localization of the uptake on SPECT but there is no guideline about the optimal CT acquisition parameters. In our department, a standard CT acquisition protocol was changed in 2013 to give lower radiation dose to the patient. In this study, we retrospectively compared the effects on patient dose as well as the CT image quality with current versus older CT protocols. Ninety nine consecutive patients [n=51 Standard dose ‘old’ protocol (SDP); n=48 lower dose ‘new’ protocol (LDP)] with lumbar spine SPECT-CT for bone scan were examined. The main differences between the two protocols were that SDP used 130 kVp tube voltage and reference current-time product of 70 mAs whereas the LDP used 110 kVp and 40 mAs respectively. Various quantitative parameters from the CT images were obtained and the images were also rated blindly by two experienced nuclear medicine physicians for bony definition and noise. The mean calculated dose length product of the LDP group (121.5±39.6 mGy.cm) was significantly lower compared to the SDP group patients (266.9±96.9 mGy.cm; P<0.0001). This translated into a significant reduction in the mean effective dose to 1.8 mSv from 4.0 mSv. The physicians reported better CT image quality for the bony structures in LDP group although for soft tissue structures, the SDP group had better image quality. The optimized new CT acquisition protocol significantly reduced the radiation dose to the patient and in-fact improved CT image quality for the assessment of bony structures. PMID:28533938

Streptococcus pneumoniae Carriage Prevalence in Nepal: Evaluation of a Method for Delayed Transport of Samples from Remote Regions and Implications for Vaccine Implementation

PubMed Central

Hanieh, Sarah; Hamaluba, Mainga; Kelly, Dominic F.; Metz, Jane A.; Wyres, Kelly L.; Fisher, Roberta; Pradhan, Rahul; Shakya, Disuja; Shrestha, Lochan; Shrestha, Amrita; Joshi, Anip; Habens, Jocelyn; Maharjan, Bishnu D.; Thorson, Stephen; Bohler, Erik; Yu, Ly-Mee; Kelly, Sarah; Plested, Emma; John, Tessa; Werno, Anja M.; Adhikari, Neelam; Murdoch, David R.; Brueggemann, Angela B.; Pollard, Andrew J.

2014-01-01

Background Pneumococcal disease is a significant cause of morbidity and mortality in young children in Nepal, and currently available pneumococcal conjugate vaccines offer moderate coverage of invasive disease isolates. Methods A prevalence study of children aged 1.5 to 24 months in urban and rural Nepal was conducted. In the urban group, nasopharyngeal swabs (NPS) were transported using silica desiccant packages (SDP) with delayed processing (2 weeks), or skim-milk-tryptone-glucose-glycerin (STGG) with immediate processing (within 8 hours). Pneumococcal nasopharyngeal carriage prevalence, serogroup/type distribution and isolate genotypes (as defined by multilocus sequence typing) were determined. Results 1101 children were enrolled into the study: 574 in the urban group and 527 in the rural group. Overall carriage prevalence based on culture from specimens transported and stored in STGG was 58.7% (337/574), compared to 40.9% (235/574) in SDP. There was concordance of detection of pneumococcus in 67% of samples. Using the SDP method, pneumococcal carriage prevalence was higher in the rural population (69.2%; 364/526) compared to the urban population (40.9%; 235/574). Serogroup/type distribution varied with geographical location. Over half of the genotypes identified in both the urban and rural pneumococcal populations were novel. Conclusion The combination of delayed culture and transport using SDP underestimates the prevalence of pneumococcal carriage; however, in remote areas, this method could still provide a useful estimate of carriage prevalence and serogroup/type distribution. Vaccine impact is unpredictable in a setting with novel genotypes and limited serotype coverage as described here. Consequently, continued surveillance of pneumococcal isolates from carriage and disease in Nepali children following the planned introduction of pneumococcal conjugate vaccines introduction will be essential. PMID:24905574

A time-dependent neutron transport method of characteristics formulation with time derivative propagation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoffman, Adam J., E-mail: adamhoff@umich.edu; Lee, John C., E-mail: jcl@umich.edu

2016-02-15

A new time-dependent Method of Characteristics (MOC) formulation for nuclear reactor kinetics was developed utilizing angular flux time-derivative propagation. This method avoids the requirement of storing the angular flux at previous points in time to represent a discretized time derivative; instead, an equation for the angular flux time derivative along 1D spatial characteristics is derived and solved concurrently with the 1D transport characteristic equation. This approach allows the angular flux time derivative to be recast principally in terms of the neutron source time derivatives, which are approximated to high-order accuracy using the backward differentiation formula (BDF). This approach, called Sourcemore » Derivative Propagation (SDP), drastically reduces the memory requirements of time-dependent MOC relative to methods that require storing the angular flux. An SDP method was developed for 2D and 3D applications and implemented in the computer code DeCART in 2D. DeCART was used to model two reactor transient benchmarks: a modified TWIGL problem and a C5G7 transient. The SDP method accurately and efficiently replicated the solution of the conventional time-dependent MOC method using two orders of magnitude less memory.« less

Economic effect of short (35-d) compared with conventional (60-d) dry period management in commercial Canadian Holstein herds.

PubMed

Santschi, D E; Lefebvre, D M; Cue, R I; Girard, C L; Pellerin, D

2011-09-01

The Canadian dairy industry operates under a supply management system with production quotas (expressed in kilograms of butterfat per day) owned by dairy producers. Any management strategy influencing production responses must, therefore, be evaluated to estimate its effects on quota needed to sell the milk produced. In the present study, half of the cows from 13 commercial herds (850 cows, average of 70 cows per herd) were assigned to be managed for a short dry period (SDP; 35 d dry) and the other half was managed for a conventional dry period (CDP; 60 d dry) to evaluate the economic impact of a steady state involving either CDP or SDP. Economic variables included in the partial budget were: variations in revenues from milk and components as well as animals sold; costs related to feeding, reproduction, replacement, housing, and treatments. All variables were first estimated on a cow basis for each herd individually, and average results were used to calculate the partial budget for an average herd. Yearly milk and component yields per cow increased, which implies that fewer cows are required to produce the same amount of quota. Accordingly, 2 scenarios were investigated: in the first one, available quota was kept constant, and herd size was adjusted to avoid over-quota production. Consequently, the partial budget was calculated considering that 5 fewer cows were present in the herd. In this situation, switching to an SDP management increased net annual income for the farm by $2,677 (Can$), which represents $41.38 per cow. In the second scenario, the number of cows was kept constant, but additional quota (5.5 kg/d, $25,000/kg) was bought to allow selling all of the milk produced. In this case, net farm income was increased by $17,132 annually with SDP, which represents $245.18 per cow. This budget includes interest on the purchase of quota. A comparison of partial budgets for individual herds involved in the study revealed considerable variation among herds. Switching from a CDP to a SDP management would be beneficial for average dairy herds in eastern Canada. Copyright © 2011 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Comparison of shortened and conventional dry period management strategies.

PubMed

Cermakova, J; Kudrna, V; Simeckova, M; Vyborna, A; Dolezal, P; Illek, J

2014-09-01

The aim of this study was to compare 2 dry-cow management strategies and evaluate the effect of shortened dry period strategy on feed intake, metabolism, and postpartum performance of dairy cows in early lactation. Twenty-nine high-yielding dairy cows were divided into 2 groups. The control (CON) group (n=14) was assigned to a traditional dry period of approximately 60 d (57±5.9 d) and was fed a far-off dry cow ration from dry-off to -21 d relative to expected parturition. From d -21 relative to expected parturition, the cows were switched to a precalving ration containing an additional 3kg of concentrates. The cows of the experimental group (n=15) were assigned to a shortened dry period (SDP; 35±6.3 d) and were continuously fed a late-lactation diet from d -60 d relative to expected parturition until calving. After calving, both groups were fed the same lactation diet corresponding to their lactation requirements and cows were followed for 100 d of lactation. Prepartum dry matter intake of the cows assigned to an SDP and fed a late-lactation diet was approximately 4.11kg/cow per day greater compared with the CON group during the 60 d. However, no effect of dry period strategy on postpartum dry matter intake was detected. The cows with an SDP produced approximately 2.78kg/d (6.9%) less milk in the first 100 d of lactation than CON cows; the difference was not statistically significant. No differences were observed in live body weight, body condition score, or back-fat thickness between the treatments. Similarly, no differences existed in concentrations of plasma metabolites. The cows of the SDP group showed lower pH and increased concentrations of lactic acid and volatile fatty acids prepartum than the CON cows. Postpartum concentrations of lactic acid, volatile fatty acids, and NH3 and pH in rumen fluid did not differ between the treatments. Shortening of the dry period did not affect the colostrum quality or birth weights of the calves. Based on the results of this study, a traditional dry period management strategy appeared to be more favorable, considering the dry matter intake and milk production, compared with an SDP and feeding a late-lactation diet throughout the dry period. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

What is the real price of hydroelectric production on the Senegal River?

NASA Astrophysics Data System (ADS)

Raso, Luciano; Bader, Jean-Claude; Malaterre, Pierre-Olivier

2014-05-01

Manantali is an annual reservoir on the Senegal River, located in Mali and serving Senegal and Mauritania. The reservoir is used to regulate the flow for hydroelectric production, in the face of the extremely variable seasonal climate of the region. Manantali has been operative for about 10 years now, exceeding the planned production capacity. The economic benefit comes at a price. Before the dam's construction, the annual flood was the basis of flood recession agriculture, traditionally practiced by the local population. Hydroelectric production requires a more regular flow; therefore flow peaks that used to create the flood are now dumped in the reservoir. Floods are reduced because the current reservoir management privileges hydroelectric production to flood recession agriculture. Moreover, the local water authority is evaluating the construction of 6 more reservoirs, which will enhance even further the controllability of the river flow. This study assesses the externalities of energy production for the agricultural production, quantifying the reduction of flooded surface when energy production is maximized, or alternatively, the loss energy production to maintain a minimum sustainable flood. In addition, we examine the system reliability against extreme events, and how a better use of hydrological information can improve the present reservoir management, in order to find a win-win solution. In this study we employ Stochastic Dual Dynamic Programming (SDDP) methodology. SDDP is a leaner version of Stochastic Dynamic Programming (SDP). SDDP does not suffer of the "curse of dimensionality", and therefore it can be applied to larger systems. In this application we include in the model: i) A semi-distributed hydrological model, ii) the reservoir, iii) the hydraulic routing process within the catchment and from the reservoir to the floodplain.

Extraction of 3D Femur Neck Trabecular Bone Architecture from Clinical CT Images in Osteoporotic Evaluation: a Novel Framework.

PubMed

Sapthagirivasan, V; Anburajan, M; Janarthanam, S

2015-08-01

The early detection of osteoporosis risk enhances the lifespan and quality of life of an individual. A reasonable in-vivo assessment of trabecular bone strength at the proximal femur helps to evaluate the fracture risk and henceforth, to understand the associated structural dynamics on occurrence of osteoporosis. The main aim of our study was to develop a framework to automatically determine the trabecular bone strength from clinical femur CT images and thereby to estimate its correlation with BMD. All the 50 studied south Indian female subjects aged 30 to 80 years underwent CT and DXA measurements at right femur region. Initially, the original CT slices were intensified and active contour model was utilised for the extraction of the neck region. After processing through a novel process called trabecular enrichment approach (TEA), the three dimensional (3D) trabecular features were extracted. The extracted 3D trabecular features, such as volume fraction (VF), solidity of delta points (SDP) and boundness, demonstrated a significant correlation with femoral neck bone mineral density (r = 0.551, r = 0.432, r = 0.552 respectively) at p < 0.001. The higher area under the curve values of the extracted features (VF: 85.3 %; 95CI: 68.2-100 %, SDP: 82.1 %; 95CI: 65.1-98.9 % and boundness: 90.4 %; 95CI: 78.7-100 %) were observed. The findings suggest that the proposed framework with TEA method would be useful for spotting women vulnerable to osteoporotic risk.

Effect of Streamflow Forecast Uncertainty on Real-Time Reservoir Operation

NASA Astrophysics Data System (ADS)

Zhao, T.; Cai, X.; Yang, D.

2010-12-01

Various hydrological forecast products have been applied to real-time reservoir operation, including deterministic streamflow forecast (DSF), DSF-based probabilistic streamflow forecast (DPSF), and ensemble streamflow forecast (ESF), which represent forecast uncertainty in the form of deterministic forecast error, deterministic forecast error-based uncertainty distribution, and ensemble forecast errors, respectively. Compared to previous studies that treat these forecast products as ad hoc inputs for reservoir operation models, this paper attempts to model the uncertainties involved in the various forecast products and explores their effect on real-time reservoir operation decisions. In hydrology, there are various indices reflecting the magnitude of streamflow forecast uncertainty; meanwhile, few models illustrate the forecast uncertainty evolution process. This research introduces Martingale Model of Forecast Evolution (MMFE) from supply chain management and justifies its assumptions for quantifying the evolution of uncertainty in streamflow forecast as time progresses. Based on MMFE, this research simulates the evolution of forecast uncertainty in DSF, DPSF, and ESF, and applies the reservoir operation models (dynamic programming, DP; stochastic dynamic programming, SDP; and standard operation policy, SOP) to assess the effect of different forms of forecast uncertainty on real-time reservoir operation. Through a hypothetical single-objective real-time reservoir operation model, the results illustrate that forecast uncertainty exerts significant effects. Reservoir operation efficiency, as measured by a utility function, decreases as the forecast uncertainty increases. Meanwhile, these effects also depend on the type of forecast product being used. In general, the utility of reservoir operation with ESF is nearly as high as the utility obtained with a perfect forecast; the utilities of DSF and DPSF are similar to each other but not as efficient as ESF. Moreover, streamflow variability and reservoir capacity can change the magnitude of the effects of forecast uncertainty, but not the relative merit of DSF, DPSF, and ESF. Schematic diagram of the increase in forecast uncertainty with forecast lead-time and the dynamic updating property of real-time streamflow forecast

Design of a multiple kernel learning algorithm for LS-SVM by convex programming.

PubMed

Jian, Ling; Xia, Zhonghang; Liang, Xijun; Gao, Chuanhou

2011-06-01

As a kernel based method, the performance of least squares support vector machine (LS-SVM) depends on the selection of the kernel as well as the regularization parameter (Duan, Keerthi, & Poo, 2003). Cross-validation is efficient in selecting a single kernel and the regularization parameter; however, it suffers from heavy computational cost and is not flexible to deal with multiple kernels. In this paper, we address the issue of multiple kernel learning for LS-SVM by formulating it as semidefinite programming (SDP). Furthermore, we show that the regularization parameter can be optimized in a unified framework with the kernel, which leads to an automatic process for model selection. Extensive experimental validations are performed and analyzed. Copyright © 2011 Elsevier Ltd. All rights reserved.

A Conserved Non-Canonical Docking Mechanism Regulates the Binding of Dual Specificity Phosphatases to Cell Integrity Mitogen-Activated Protein Kinases (MAPKs) in Budding and Fission Yeasts

PubMed Central

Sacristán-Reviriego, Almudena; Madrid, Marisa; Cansado, José; Martín, Humberto; Molina, María

2014-01-01

Dual-specificity MAPK phosphatases (MKPs) are essential for the negative regulation of MAPK pathways. Similar to other MAPK-interacting proteins, most MKPs bind MAPKs through specific docking domains known as D-motifs. However, we found that the Saccharomyces cerevisiae MKP Msg5 binds the MAPK Slt2 within the cell wall integrity (CWI) pathway through a distinct motif (IYT). Here, we demonstrate that the IYT motif mediates binding of the Msg5 paralogue Sdp1 to Slt2 as well as of the MKP Pmp1 to its CWI MAPK counterpart Pmk1 in the evolutionarily distant yeast Schizosaccharomyces pombe. As a consequence, removal of the IYT site in Msg5, Sdp1 and Pmp1 reduces MAPK trapping caused by the overexpression of catalytically inactive versions of these phosphatases. Accordingly, an intact IYT site is necessary for inactive Sdp1 to prevent nuclear accumulation of Slt2. We also show that both Ile and Tyr but not Thr are essential for the functionality of the IYT motif. These results provide mechanistic insight into MKP-MAPK interplay and stress the relevance of this conserved non-canonical docking site in the regulation of the CWI pathway in fungi. PMID:24465549

Passive rGE or developmental gene-environment cascade? An investigation of the role of xenobiotic metabolism genes in the association between smoke exposure during pregnancy and child birth weight

PubMed Central

Marceau, Kristine; Palmer, Rohan H.C.; Neiderhiser, Jenae M.; Smith, Taylor F.; McGeary, John E.; Knopik, Valerie S.

2016-01-01

There is considerable evidence that smoke exposure during pregnancy (SDP) environmentally influences birth weight after controlling for genetic influences and maternal characteristics. However, maternal smoking during pregnancy – the behavior that leads to smoke exposure during pregnancy – is also genetically-influenced, indicating the potential role of passive gene-environment correlation. An alternative to passive gene-SDP correlation is a cascading effect whereby maternal and child genetic influences are causally linked to prenatal exposures, which then have an ‘environmental’ effect on the development of the child’s biology and behavior. We describe and demonstrate a conceptual framework for disentangling passive rGE from this cascading GE effect using a systems-based polygenic scoring approach comprised of genes shown to be important in the xenobiotic (substances foreign to the body) metabolism pathway. Data were drawn from 5,044 families from the Avon Longitudinal Study of Parents and Children with information on maternal SDP, birth weight, and genetic polymorphisms in the xenobiotic pathway. Within a k-fold cross-validation approach (k=5), we created weighted maternal and child polygenic scores using 18 polymorphisms from 10 genes that have been implicated in the xenobiotic metabolism pathway. Mothers and children shared variation in xenobiotic metabolism genes. Amongst mothers who smoked during pregnancy, neither maternal nor child xenobiotic metabolism polygenic scores were associated with a higher likelihood of smoke exposure during pregnancy, or the severity of smoke exposure during pregnancy (and therefore, neither proposed mechanism was supported), or with child birth weight. SDP was consistently associated with lower child birth weight controlling for the polygenic scores, maternal educational attainment, social class, psychiatric problems, and age. Limitations of the study design and the potential of the framework using other designs are discussed. PMID:26803317

Stochastic Control of Energy Efficient Buildings: A Semidefinite Programming Approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Xiao; Dong, Jin; Djouadi, Seddik M

2015-01-01

The key goal in energy efficient buildings is to reduce energy consumption of Heating, Ventilation, and Air- Conditioning (HVAC) systems while maintaining a comfortable temperature and humidity in the building. This paper proposes a novel stochastic control approach for achieving joint performance and power control of HVAC. We employ a constrained Stochastic Linear Quadratic Control (cSLQC) by minimizing a quadratic cost function with a disturbance assumed to be Gaussian. The problem is formulated to minimize the expected cost subject to a linear constraint and a probabilistic constraint. By using cSLQC, the problem is reduced to a semidefinite optimization problem, wheremore » the optimal control can be computed efficiently by Semidefinite programming (SDP). Simulation results are provided to demonstrate the effectiveness and power efficiency by utilizing the proposed control approach.« less

Amortization does not enhance the max-Rains information of a quantum channel

NASA Astrophysics Data System (ADS)

Berta, Mario; Wilde, Mark M.

2018-05-01

Given an entanglement measure E, the entanglement of a quantum channel is defined as the largest amount of entanglement E that can be generated from the channel, if the sender and receiver are not allowed to share a quantum state before using the channel. The amortized entanglement of a quantum channel is defined as the largest net amount of entanglement E that can be generated from the channel, if the sender and receiver are allowed to share an arbitrary state before using the channel. Our main technical result is that amortization does not enhance the entanglement of an arbitrary quantum channel, when entanglement is quantified by the max-Rains relative entropy. We prove this statement by employing semi-definite programming (SDP) duality and SDP formulations for the max-Rains relative entropy and a channel’s max-Rains information, found recently in Wang et al (arXiv:1709.00200). The main application of our result is a single-letter, strong converse, and efficiently computable upper bound on the capacity of a quantum channel for transmitting qubits when assisted by positive-partial-transpose preserving (PPT-P) channels between every use of the channel. As the class of local operations and classical communication (LOCC) is contained in PPT-P, our result establishes a benchmark for the LOCC-assisted quantum capacity of an arbitrary quantum channel, which is relevant in the context of distributed quantum computation and quantum key distribution.

Stochastic control of smart home energy management with plug-in electric vehicle battery energy storage and photovoltaic array

NASA Astrophysics Data System (ADS)

Wu, Xiaohua; Hu, Xiaosong; Moura, Scott; Yin, Xiaofeng; Pickert, Volker

2016-11-01

Energy management strategies are instrumental in the performance and economy of smart homes integrating renewable energy and energy storage. This article focuses on stochastic energy management of a smart home with PEV (plug-in electric vehicle) energy storage and photovoltaic (PV) array. It is motivated by the challenges associated with sustainable energy supplies and the local energy storage opportunity provided by vehicle electrification. This paper seeks to minimize a consumer's energy charges under a time-of-use tariff, while satisfying home power demand and PEV charging requirements, and accommodating the variability of solar power. First, the random-variable models are developed, including Markov Chain model of PEV mobility, as well as predictive models of home power demand and PV power supply. Second, a stochastic optimal control problem is mathematically formulated for managing the power flow among energy sources in the smart home. Finally, based on time-varying electricity price, we systematically examine the performance of the proposed control strategy. As a result, the electric cost is 493.6% less for a Tesla Model S with optimal stochastic dynamic programming (SDP) control relative to the no optimal control case, and it is by 175.89% for a Nissan Leaf.

The Chandra Source Catalog: Processing and Infrastructure

NASA Astrophysics Data System (ADS)

Evans, Janet; Evans, Ian N.; Glotfelty, Kenny J.; Hain, Roger; Hall, Diane M.; Miller, Joseph B.; Plummer, David A.; Zografou, Panagoula; Primini, Francis A.; Anderson, Craig S.; Bonaventura, Nina R.; Chen, Judy C.; Davis, John E.; Doe, Stephen M.; Fabbiano, Giuseppina; Galle, Elizabeth C.; Gibbs, Danny G., II; Grier, John D.; Harbo, Peter N.; He, Xiang Qun (Helen); Houck, John C.; Karovska, Margarita; Kashyap, Vinay L.; Lauer, Jennifer; McCollough, Michael L.; McDowell, Jonathan C.; Mitschang, Arik W.; Morgan, Douglas L.; Mossman, Amy E.; Nichols, Joy S.; Nowak, Michael A.; Refsdal, Brian L.; Rots, Arnold H.; Siemiginowska, Aneta L.; Sundheim, Beth A.; Tibbetts, Michael S.; van Stone, David W.; Winkelman, Sherry L.

2009-09-01

Chandra Source Catalog processing recalibrates each observation using the latest available calibration data, and employs a wavelet-based source detection algorithm to identify all the X-ray sources in the field of view. Source properties are then extracted from each detected source that is a candidate for inclusion in the catalog. Catalog processing is completed by matching sources across multiple observations, merging common detections, and applying quality assurance checks. The Chandra Source Catalog processing system shares a common processing infrastructure and utilizes much of the functionality that is built into the Standard Data Processing (SDP) pipeline system that provides calibrated Chandra data to end-users. Other key components of the catalog processing system have been assembled from the portable CIAO data analysis package. Minimal new software tool development has been required to support the science algorithms needed for catalog production. Since processing pipelines must be instantiated for each detected source, the number of pipelines that are run during catalog construction is a factor of order 100 times larger than for SDP. The increased computational load, and inherent parallel nature of the processing, is handled by distributing the workload across a multi-node Beowulf cluster. Modifications to the SDP automated processing application to support catalog processing, and extensions to Chandra Data Archive software to ingest and retrieve catalog products, complete the upgrades to the infrastructure to support catalog processing.

Synthetic diagnostics platform for fusion plasmas (invited)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shi, L., E-mail: lshi@pppl.gov; Valeo, E. J.; Tobias, B. J.

A Synthetic Diagnostics Platform (SDP) for fusion plasmas has been developed which provides state of the art synthetic reflectometry, beam emission spectroscopy, and Electron Cyclotron Emission (ECE) diagnostics. Interfaces to the plasma simulation codes GTC, XGC-1, GTS, and M3D-C{sup 1} are provided, enabling detailed validation of these codes. In this paper, we give an overview of SDP’s capabilities, and introduce the synthetic diagnostic modules. A recently developed synthetic ECE Imaging module which self-consistently includes refraction, diffraction, emission, and absorption effects is discussed in detail. Its capabilities are demonstrated on two model plasmas. The importance of synthetic diagnostics in validation ismore » shown by applying the SDP to M3D-C{sup 1} output and comparing it with measurements from an edge harmonic oscillation mode on DIII-D.« less

Recycling of Exhaust Batteries in Lead-Foam Electrodes

NASA Astrophysics Data System (ADS)

Costanza, Girolamo; Tata, Maria Elisa

Lead and lead-alloy foams have been investigated in this research. In particular low-cost techniques for the direct production of lead-based electrodes have been analyzed and discussed in this work. The relevance of the main process parameters (powder compacting pressure, granulometry, base metal composition, sintering temperature and time) have been focused and the effect on foam morphology has been discussed too. In particular "Sintering and Dissolution Process" (SDP) and "Replication Process" (RP) have been employed and suitable modified. Both spherical urea and NaCl have been adopted in the SDP method. In the replication process it has been evidenced that the viscosity of the melt is fundamental. Furthermore the research examines lead recovery and recycling of exhaust batteries into foam-based electrodes. A novel method for the direct conversion of Pb scrap into lead foam is discussed too.

Seismic Constraints on the Lithosphere-Asthenosphere Boundary Beneath the Izu-Bonin Area: Implications for the Oceanic Lithospheric Thinning

NASA Astrophysics Data System (ADS)

Cui, Qinghui; Wei, Rongqiang; Zhou, Yuanze; Gao, Yajian; Li, Wenlan

2018-01-01

The lithosphere-asthenosphere boundary (LAB) is the seismic discontinuity with negative velocity contrasts in the upper mantle. Seismic detections on the LAB are of great significance in understanding the plate tectonics, mantle convection and lithospheric evolution. In this paper, we study the LAB in the Izu-Bonin subduction zone using four deep earthquakes recorded by the permanent and temporary seismic networks of the USArray. The LAB is clearly revealed with sP precursors (sdP) through the linear slant stacking. As illustrated by reflected points of the identified sdP phases, the depth of LAB beneath the Izu-Bonin Arc (IBA) is about 65 km with a range of 60-68 km. The identified sdP phases with opposite polarities relative to sP phases have the average relative amplitude of 0.21, which means a 3.7% velocity drop and implies partial melting in the asthenosphere. On the basis of the crustal age data, the lithosphere beneath the IBA is located at the 1100 °C isotherm calculated with the GDH1 model. Compared to tectonically stable areas, such as the West Philippine Basin (WPB) and Parece Vela Basin (PVB) in the Philippine Sea, the lithosphere beneath the Izu-Bonin area shows the obvious lithospheric thinning. According to the geodynamic and petrological studies, the oceanic lithospheric thinning phenomenon can be attributed to the strong erosion of the small-scale convection in the mantle wedge enriched in volatiles and melts.

Missouri Mothers and Their Children: A Family Study of the Effects of Genetics and the Prenatal Environment.

PubMed

Knopik, Valerie S; Heath, Andrew C; Marceau, Kristine; Palmer, Rohan H C; McGeary, John E; Todorov, Alexandre; Evans, Allison Schettini

2015-10-01

The Missouri Mothers and Their Children Study (MO-MATCH) was specifically designed to critically investigate prenatal environmental influences on child attention problems and associated learning and cognitive deficits. The project began as a pilot study in 2004 and was formally launched in 2008. Participants in the study were initially identified via the Department of Vital Statistics birth record (BR) database. Interview and lab-based data were obtained from: (1) mothers of Missouri-born children (born 1998-2005), who smoked during one pregnancy but not during another pregnancy; (2) biological fathers when available; and (3) the children (i.e., full sibling pairs discordant for exposure to maternal smoking during pregnancy (SDP). This within-mother, between-pregnancy contrast provides the best possible methodological control for many stable maternal and familial confounding factors (e.g., heritable and socio-demographic characteristics of the mother that predict increased probability of SDP). It also controls for differences between mothers who do and do not smoke during pregnancy, and their partners, that might otherwise artifactually create, or alternatively mask, associations between SDP and child outcomes. Such a design will therefore provide opportunities to determine less biased effect sizes while also allowing us to investigate (on a preliminary basis) the possible contribution of paternal or other second-hand smoke exposure during the pre, peri, and postnatal periods to offspring outcome. This protocol has developed a cohort that can be followed longitudinally through periods typically associated with increased externalizing symptoms and substance used initiation.

A hybrid model based on neural networks for biomedical relation extraction.

PubMed

Zhang, Yijia; Lin, Hongfei; Yang, Zhihao; Wang, Jian; Zhang, Shaowu; Sun, Yuanyuan; Yang, Liang

2018-05-01

Biomedical relation extraction can automatically extract high-quality biomedical relations from biomedical texts, which is a vital step for the mining of biomedical knowledge hidden in the literature. Recurrent neural networks (RNNs) and convolutional neural networks (CNNs) are two major neural network models for biomedical relation extraction. Neural network-based methods for biomedical relation extraction typically focus on the sentence sequence and employ RNNs or CNNs to learn the latent features from sentence sequences separately. However, RNNs and CNNs have their own advantages for biomedical relation extraction. Combining RNNs and CNNs may improve biomedical relation extraction. In this paper, we present a hybrid model for the extraction of biomedical relations that combines RNNs and CNNs. First, the shortest dependency path (SDP) is generated based on the dependency graph of the candidate sentence. To make full use of the SDP, we divide the SDP into a dependency word sequence and a relation sequence. Then, RNNs and CNNs are employed to automatically learn the features from the sentence sequence and the dependency sequences, respectively. Finally, the output features of the RNNs and CNNs are combined to detect and extract biomedical relations. We evaluate our hybrid model using five public (protein-protein interaction) PPI corpora and a (drug-drug interaction) DDI corpus. The experimental results suggest that the advantages of RNNs and CNNs in biomedical relation extraction are complementary. Combining RNNs and CNNs can effectively boost biomedical relation extraction performance. Copyright © 2018 Elsevier Inc. All rights reserved.

Absence of sex differential plasticity to light availability during seed maturation in Geranium sylvaticum.

PubMed

Varga, Sandra; Laaksonen, Ester; Siikamäki, Pirkko; Kytöviita, Minna-Maarit

2015-01-01

Sex-differential plasticity (SDP) hypothesis suggests that since hermaphrodites gain fitness through both pollen and seed production they may have evolved a higher degree of plasticity in their reproductive strategy compared to females which achieve fitness only through seed production. SDP may explain the difference in seed production observed between sexes in gynodioecious species in response to resource (nutrients or water) availability. In harsh environments, hermaphrodites decrease seed production whereas females keep it relatively similar regardless of the environmental conditions. Light availability can be also a limiting resource and thus could theoretically affect differently female and hermaphrodite seed output even though this ecological factor has been largely overlooked. We tested whether the two sexes in the gynodioecious species Geranium sylvaticum differ in their tolerance to light limitation during seed maturation in the field. We used a fully factorial block experiment exposing female and hermaphrodite plants to two different light environments (control and shade) after their peak flowering period. Specifically, we measured fruit and seed production in response to decreased light availability and compared it between the sexes. Shading reduced the number of fruits and seeds produced, but the decrease was similar between the sexes. Furthermore, shading delayed seed production by three days in both sexes, but did not affect seed mass, seed P content, or the probability of re-flowering the following year. Our results give no evidence for reproductive SDP in response to light during seed maturation.

Confirmatory factor analysis of Post-Occupancy Evaluation Model (POEM) for sustainable neighborhood development

NASA Astrophysics Data System (ADS)

Yaman, R.; Thadaniti, S.; Abdullah, J.; Ahmad, N.; Ishak, N. M.

2018-02-01

The sustainable urban development growth in the ASEAN region has accelerated tremendously. More demand on the sustainable development has led to bigger market driven certified green neighborhood and buildings. However, there is a lack of post-occupancy evaluation study conducted in assessing the end-users perspective on the certified sustainable neighborhood development. This paper aims to investigate the end-users point of view on sustainable dimension pillar (SDP) adaptation based on environment dimension, social dimension and economic dimension using Post-Occupancy Evaluation Model (POEM) framework. The research methodology employed stakeholders-Inclusion Approach survey questionnaires in order to obtained the sustainable dimensional adaptation score. The results show that there is sustainable dimension gap in POEM evaluation, hence, suggested the pre- occupancy criteria did not fulfill the SDP adaptation and pre-occupancy criteria and variables if differ from post-occupancy criteria and variables.

Facet-Dependent Property of Sequentially Deposited Perovskite Thin Films: Chemical Origin and Self-Annihilation.

PubMed

Zhang, Tiankai; Long, Mingzhu; Yan, Keyou; Zeng, Xiaoliang; Zhou, Fengrui; Chen, Zefeng; Wan, Xi; Chen, Kun; Liu, Pengyi; Li, Faming; Yu, Tao; Xie, Weiguang; Xu, Jianbin

2016-11-30

Quantification of intergrain length scale properties of CH 3 NH 3 PbI 3 (MAPbI 3 ) can provide further understanding of material physics, leading to improved device performance. In this work, we noticed that two typical types of facets appear in sequential deposited perovskite (SDP) films: smooth and steplike morphologies. By mapping the surface potential as well as the photoluminescence (PL) peak position, we revealed the heterogeneity of SDP thin films that smooth facets are almost intrinsic with a PL peak at 775 nm, while the steplike facets are p-type-doped with 5-nm blue-shifted PL peak. Considering the reaction process, we propose that the smooth facets have well-defined crystal lattices that resulted from the interfacial reaction between MAI and PbI 2 domains containing low trap states density. The steplike facets are MAI-rich originated from the grain boundaries of PbI 2 film and own more trap states. Conversion of steplike facets to smooth facets can be controlled by increasing the reaction time through Ostwald ripening. The improved stability, photoresponsivity up to 0.3 A/W, on/off ratio up to 3900, and decreased photo response time to ∼160 μs show that the trap states can be annihilated effectively to improve the photoelectrical conversion with prolonged reaction time and elimination of steplike facets. Our findings demonstrate the relationship between the facet heterogeneity of SDP films and crystal growth process for the first time, and imply that the systematic control of crystal grain modification will enable amelioration of crystallinity for more-efficient perovskite photoelectrical applications.

Model-based Approaches for the Determination of Lipid Bilayer Structure from Small-Angle Neutron and X-ray Scattering Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heberle, Frederick A; Pan, Jianjun; Standaert, Robert F

2012-01-01

Some of our recent work has resulted in the detailed structures of fully hydrated, fluid phase phosphatidylcholine (PC) and phosphatidylglycerol (PG) bilayers. These structures were obtained from the joint refinement of small-angle neutron and X-ray data using the scattering density profile (SDP) models developed by Ku erka et al. (Ku erka et al. 2012; Ku erka et al. 2008). In this review, we first discuss models for the standalone analysis of neutron or X-ray scattering data from bilayers, and assess the strengths and weaknesses inherent in these models. In particular, it is recognized that standalone data do not contain enoughmore » information to fully resolve the structure of inherently disordered fluid bilayers, and therefore may not provide a robust determination of bilayer structural parameters, including the much sought after area per lipid. We then discuss the development of matter density-based models (including the SDP model) that allow for the joint refinement of different contrast neutron and X-ray data sets, as well as the implementation of local volume conservation in the unit cell (i.e., ideal packing). Such models provide natural definitions of bilayer thicknesses (most importantly the hydrophobic and Luzzati thicknesses) in terms of Gibbs dividing surfaces, and thus allow for the robust determination of lipid areas through equivalent slab relationships between bilayer thickness and lipid volume. In the final section of this review, we discuss some of the significant findings/features pertaining to structures of PC and PG bilayers as determined from SDP model analyses.« less

Quantum Correlation Properties in Two Qubits One-axis Spin Squeezing Model

NASA Astrophysics Data System (ADS)

Guo-Hui, Yang

2017-02-01

Using the concurrence (C) and quantum discord (QD) criterions, the quantum correlation properties in two qubits one-axis spin squeezing model with an external magnetic field are investigated. It is found that one obvious difference in the limit case T → 0 (ground state) is the sudden disappearance phenomenon (SDP) occured in the behavior of C, while not in QD. In order to further explain the SDP, we obtain the analytic expressions of ground state C and QD which reveal that the SDP is not really "entanglement sudden disappeared", it is decayed to zero very quickly. Proper tuning the parameters μ(the spin squeezing interaction in x direction) and Ω(the external magnetic field in z direction) not only can obviously broaden the scope of ground state C exists but also can enhance the value of ground state QD. For the finite temperature case, one evident difference is that the sudden birth phenomenon (SBP) is appeared in the evolution of C, while not in QD, and decreasing the coupling parameters μ or Ω can obviously prolong the time interval before entanglement sudden birth. The value of C and QD are both enhanced by increasing the parameters μ or Ω in finite temperature case. In addition, through investigating the effects of temperature T on the quantum correlation properties with the variation of Ω and μ, one can find that the temperature scope of C and QD exists are broadened with increasing the parameters μ or Ω, and one can obtain the quantum correlation at higher temperature through changing these parameters.

Algorithms for sum-of-squares-based stability analysis and control design of uncertain nonlinear systems

NASA Astrophysics Data System (ADS)

Ataei-Esfahani, Armin

In this dissertation, we present algorithmic procedures for sum-of-squares based stability analysis and control design for uncertain nonlinear systems. In particular, we consider the case of robust aircraft control design for a hypersonic aircraft model subject to parametric uncertainties in its aerodynamic coefficients. In recent years, Sum-of-Squares (SOS) method has attracted increasing interest as a new approach for stability analysis and controller design of nonlinear dynamic systems. Through the application of SOS method, one can describe a stability analysis or control design problem as a convex optimization problem, which can efficiently be solved using Semidefinite Programming (SDP) solvers. For nominal systems, the SOS method can provide a reliable and fast approach for stability analysis and control design for low-order systems defined over the space of relatively low-degree polynomials. However, The SOS method is not well-suited for control problems relating to uncertain systems, specially those with relatively high number of uncertainties or those with non-affine uncertainty structure. In order to avoid issues relating to the increased complexity of the SOS problems for uncertain system, we present an algorithm that can be used to transform an SOS problem with uncertainties into a LMI problem with uncertainties. A new Probabilistic Ellipsoid Algorithm (PEA) is given to solve the robust LMI problem, which can guarantee the feasibility of a given solution candidate with an a-priori fixed probability of violation and with a fixed confidence level. We also introduce two approaches to approximate the robust region of attraction (RROA) for uncertain nonlinear systems with non-affine dependence on uncertainties. The first approach is based on a combination of PEA and SOS method and searches for a common Lyapunov function, while the second approach is based on the generalized Polynomial Chaos (gPC) expansion theorem combined with the SOS method and searches for parameter-dependent Lyapunov functions. The control design problem is investigated through a case study of a hypersonic aircraft model with parametric uncertainties. Through time-scale decomposition and a series of function approximations, the complexity of the aircraft model is reduced to fall within the capability of SDP solvers. The control design problem is then formulated as a convex problem using the dual of the Lyapunov theorem. A nonlinear robust controller is searched using the combined PEA/SOS method. The response of the uncertain aircraft model is evaluated for two sets of pilot commands. As the simulation results show, the aircraft remains stable under up to 50% uncertainty in aerodynamic coefficients and can follow the pilot commands.

International Network of Passive Correlation Ranging for Orbit Determination of a Geostationary Satellite

NASA Astrophysics Data System (ADS)

Kaliuzhnyi, Mykola; Bushuev, Felix; Shulga, Oleksandr; Sybiryakova, Yevgeniya; Shakun, Leonid; Bezrukovs, Vladislavs; Moskalenko, Sergiy; Kulishenko, Vladislav; Malynovskyi, Yevgen

2016-12-01

An international network of passive correlation ranging of a geostationary telecommunication satellite is considered in the article. The network is developed by the RI "MAO". The network consists of five spatially separated stations of synchronized reception of DVB-S signals of digital satellite TV. The stations are located in Ukraine and Latvia. The time difference of arrival (TDOA) on the network stations of the DVB-S signals, radiated by the satellite, is a measured parameter. The results of TDOA estimation obtained by the network in May-August 2016 are presented in the article. Orbital parameters of the tracked satellite are determined using measured values of the TDOA and two models of satellite motion: the analytical model SGP4/SDP4 and the model of numerical integration of the equations of satellite motion. Both models are realized using the free low-level space dynamics library OREKIT (ORbit Extrapolation KIT).

Analyzing the Pieces of a Warped Galaxy

NASA Image and Video Library

2010-11-04

This image composite shows a warped and magnified view of a galaxy discovered by the Herschel Space Observatory, one of five such galaxies uncovered by the infrared telescope. The galaxy, referred to as SDP 81 is the yellow dot in the left image.

A standard-driven approach for electronic submission to pharmaceutical regulatory authorities.

PubMed

Lin, Ching-Heng; Chou, Hsin-I; Yang, Ueng-Cheng

2018-03-01

Using standards is not only useful for data interchange during the process of a clinical trial, but also useful for analyzing data in a review process. Any step, which speeds up approval of new drugs, may benefit patients. As a result, adopting standards for regulatory submission becomes mandatory in some countries. However, preparing standard-compliant documents, such as annotated case report form (aCRF), needs a great deal of knowledge and experience. The process is complex and labor-intensive. Therefore, there is a need to use information technology to facilitate this process. Instead of standardizing data after the completion of a clinical trial, this study proposed a standard-driven approach. This approach was achieved by implementing a computer-assisted "standard-driven pipeline (SDP)" in an existing clinical data management system. SDP used CDISC standards to drive all processes of a clinical trial, such as the design, data acquisition, tabulation, etc. RESULTS: A completed phase I/II trial was used to prove the concept and to evaluate the effects of this approach. By using the CDISC-compliant question library, aCRFs were generated automatically when the eCRFs were completed. For comparison purpose, the data collection process was simulated and the collected data was transformed by the SDP. This new approach reduced the missing data fields from sixty-two to eight and the controlled term mismatch field reduced from eight to zero during data tabulation. This standard-driven approach accelerated CRF annotation and assured data tabulation integrity. The benefits of this approach include an improvement in the use of standards during the clinical trial and a reduction in missing and unexpected data during tabulation. The standard-driven approach is an advanced design idea that can be used for future clinical information system development. Copyright © 2018 Elsevier Inc. All rights reserved.

Development of sustained and dual drug release co-extrusion formulations for individual dosing.

PubMed

Laukamp, Eva Julia; Vynckier, An-Katrien; Voorspoels, Jody; Thommes, Markus; Breitkreutz, Joerg

2015-01-01

In personalized medicine and patient-centered medical treatment individual dosing of medicines is crucial. The Solid Dosage Pen (SDP) allows for an individual dosing of solid drug carriers by cutting them into tablet-like slices. The aim of the present study was the development of sustained release and dual release formulations with carbamazepine (CBZ) via hot-melt co-extrusion for the use in the SDP. The selection of appropriate coat- and core-formulations was performed by adapting the mechanical properties (like tensile strength and E-modulus) for example. By using different excipients (polyethyleneglycols, poloxamers, white wax, stearic acid, and carnauba wax) and drug loadings (30-50%) tailored dissolution kinetics was achieved showing cube root or zero order release mechanisms. Besides a biphasic drug release, the dose-dependent dissolution characteristics of sustained release formulations were minimized by a co-extruded wax-coated formulation. The dissolution profiles of the co-extrudates were confirmed during short term stability study (six months at 21.0 ± 0.2 °C, 45%r.h.). Due to a good layer adhesion of core and coat and adequate mechanical properties (maximum cutting force of 35.8 ± 2.0 N and 26.4 ± 2.8 N and E-modulus of 118.1 ± 8.4 and 33.9 ± 4.5 MPa for the dual drug release and the wax-coated co-extrudates, respectively) cutting off doses via the SDP was precise. While differences of the process parameters (like the barrel temperature) between the core- and the coat-layer resulted in unsatisfying content uniformities for the wax-coated co-extrudates, the content uniformity of the dual drug release co-extrudates was found to be in compliance with pharmacopoeial specification. Copyright © 2015 Elsevier B.V. All rights reserved.

Digital subtraction angiography during transjugular intrahepatic portosystemic shunt creation or revision: data on radiation exposure and image quality obtained using a standard and a low-dose acquisition protocol in a flat-panel detector-based system.

PubMed

Miraglia, Roberto; Maruzzelli, Luigi; Cortis, Kelvin; Tafaro, Corrado; Gerasia, Roberta; Parisi, Carmelo; Luca, Angelo

2015-08-01

To determine whether the use of a low-dose acquisition protocol (LDP) in digital subtraction angiography during transjugular intrahepatic portosystemic shunt (TIPS) creation/revision results in significant reduction of patient radiation exposure and adequate image quality, as compared to a default reference standard-dose acquisition protocol (SDP). Two angiographic runs were performed during TIPS creation/revision: the first following catheterization of the portal venous system and the second after stent deployment/angioplasty. Constant field of view, object to image-detector distance, and source to image-receptor distance were maintained in each patient during the two angiographic runs. 17 consecutive adult patients who underwent TIPS creation (n = 11) or TIPS revision (n = 6) from December 2013 to March 2014 were considered eligible for this single centre prospective study. In each patient, the LDP and the SDP were used in a random order for the two runs, with each patient serving as his/her own control. The dose-area product (DAP) was calculated for each image and compared. Image quality was graded by two interventional radiologists other than the operator. In all runs acquired with the LDP, image quality was considered adequate for a successful procedural outcome. The DAP per image of the LDP was numerically inferior as compared to the DAP per image of the SDP in all patients. The mean reduction in DAP per image was 75.24% ± 5.7% (p < 0. 001). Radiation exposure during TIPS creation/revision was significantly reduced by selecting a LDP in our flat-panel detector-based system, while maintaining adequate image quality.

Effects of an alveolar recruitment maneuver on subdural pressure, brain swelling, and mean arterial pressure in patients undergoing supratentorial tumour resection: a randomized crossover study.

PubMed

Flexman, Alana M; Gooderham, Peter A; Griesdale, Donald E; Argue, Ruth; Toyota, Brian

2017-06-01

Although recruitment maneuvers have been advocated as part of a lung protective ventilation strategy, their effects on cerebral physiology during elective neurosurgery are unknown. Our objectives were to determine the effects of an alveolar recruitment maneuver on subdural pressure (SDP), brain relaxation score (BRS), and cerebral perfusion pressure among patients undergoing supratentorial tumour resection. In this prospective crossover study, patients scheduled for resection of a supratentorial brain tumour were randomized to undergo either a recruitment maneuver (30 cm of water for 30 sec) or a "sham" maneuver (5 cm of water for 30 sec), followed by the alternative intervention after a 90-sec equilibration period. Subdural pressure was measured through a dural perforation following opening of the cranium. Subdural pressure and mean arterial pressure (MAP) were recorded continuously. The blinded neurosurgeon provided a BRS at baseline and at the end of each intervention. During each treatment, the changes in SDP, BRS, and MAP were compared. Twenty-one patients underwent the study procedure. The increase in SDP was higher during the recruitment maneuver than during the sham maneuver (difference, 3.9 mmHg; 95% confidence interval [CI], 2.2 to 5.6; P < 0.001). Mean arterial pressure decreased further in the recruitment maneuver than in the sham maneuver (difference, -9.0 mmHg; 95% CI, -12.5 to -5.6; P < 0.001). Cerebral perfusion pressure decreased 14 mmHg (95% CI, 4 to 24) during the recruitment maneuver. The BRS did not change with either maneuver. Our results suggest that recruitment maneuvers increase subdural pressure and reduce cerebral perfusion pressure, although the clinical importance of these findings is thus far unknown. This trial was registered with ClinicalTrials.gov, NCT02093117.

Maximizing algebraic connectivity in air transportation networks

NASA Astrophysics Data System (ADS)

Wei, Peng

In air transportation networks the robustness of a network regarding node and link failures is a key factor for its design. An experiment based on the real air transportation network is performed to show that the algebraic connectivity is a good measure for network robustness. Three optimization problems of algebraic connectivity maximization are then formulated in order to find the most robust network design under different constraints. The algebraic connectivity maximization problem with flight routes addition or deletion is first formulated. Three methods to optimize and analyze the network algebraic connectivity are proposed. The Modified Greedy Perturbation Algorithm (MGP) provides a sub-optimal solution in a fast iterative manner. The Weighted Tabu Search (WTS) is designed to offer a near optimal solution with longer running time. The relaxed semi-definite programming (SDP) is used to set a performance upper bound and three rounding techniques are discussed to find the feasible solution. The simulation results present the trade-off among the three methods. The case study on two air transportation networks of Virgin America and Southwest Airlines show that the developed methods can be applied in real world large scale networks. The algebraic connectivity maximization problem is extended by adding the leg number constraint, which considers the traveler's tolerance for the total connecting stops. The Binary Semi-Definite Programming (BSDP) with cutting plane method provides the optimal solution. The tabu search and 2-opt search heuristics can find the optimal solution in small scale networks and the near optimal solution in large scale networks. The third algebraic connectivity maximization problem with operating cost constraint is formulated. When the total operating cost budget is given, the number of the edges to be added is not fixed. Each edge weight needs to be calculated instead of being pre-determined. It is illustrated that the edge addition and the weight assignment can not be studied separately for the problem with operating cost constraint. Therefore a relaxed SDP method with golden section search is developed to solve both at the same time. The cluster decomposition is utilized to solve large scale networks.

Shared Solutions: A Model for Researcher-Practitioner Partnerships

ERIC Educational Resources Information Center

Hill, Kirsten; Reitano, Adrienne; Kowalski, David

2016-01-01

The University of Pennsylvania's Graduate School of Education (Penn GSE), and the School District of Philadelphia (SDP), have a researcher-practitioner partnership called "Shared Solutions." They consider Shared Solutions to be a hybrid of the "place-based research alliances" and "design research teams" described by…

Cannibalism enhances biofilm development in Bacillus subtilis.

PubMed

López, Daniel; Vlamakis, Hera; Losick, Richard; Kolter, Roberto

2009-11-01

Cannibalism is a mechanism to delay sporulation in Bacillus subtilis. Cannibal cells express the skf and sdp toxin systems to lyse a fraction of their sensitive siblings. The lysed cells release nutrients that serve to feed the community, effectively delaying spore formation. Here we provide evidence that the subpopulation of cells that differentiates into cannibals is the same subpopulation that produces the extracellular matrix that holds cells together in biofilms. Cannibalism and matrix formation are both triggered in response to the signalling molecule surfactin. Nutrients released by the cannibalized cells are preferentially used by matrix-producing cells, as they are the only cells expressing resistance to the Skf and Sdp toxins. As a result this subpopulation increases in number and matrix production is enhanced when cannibalism toxins are produced. The cannibal/matrix-producing subpopulation is also generated in response to antimicrobials produced by other microorganisms and may thus constitute a defense mechanism to protect B. subtilis from the action of antibiotics in natural settings.

Thoughts on the Power and Promise of Parent Organizing

ERIC Educational Resources Information Center

Quinn, Rand; Carl, Nicole Mittenfelner

2013-01-01

Urban districts throughout the nation are contending with declining enrollment, aging facilities in disrepair, persistently low student achievement, increased competition with charters, and severe fiscal constraints. Philadelphia is a case in point. Over the past year, the School District of Philadelphia (SDP) was forced to borrow $304 million…

West European and East Asian Perspectives on Defense, Deterrence and Strategy. Volume 1. Main Report.

DTIC Science & Technology

1984-05-16

this School -- especially in the SDP under David Owen’s leadership -- in raising the nuclear threshold in Europe by strengthening conventional...ConrolDEPARTMENT OF DEFENSE CONTRACTORS US European Commnand ATTN: ECJ-3 Grumman-CTEC. Inc ATTM: ECJ-5 ATTN: S. Shrier us National Military

A Technique to Propagate Clitoria fragrans from Xylopodia

DTIC Science & Technology

2015-03-01

search for other technical reports published by ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/client/default. ERDC/CRREL TR-15-5...in the greenhouse, and harvested xylopodia from the root system. We treated the xylopodia with indole- 3 -acetic acid (IAA) or indolebutyric acid... 3 3 Results

Subseabed Disposal Project annual report, FY85 to termination of project: Physical Oceanography and Water Column Geochemistry Studies, October 1984 through May 1986

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kupferman, S.L.

This report covers the work of the Physical Oceanography and Water Column Geochemistry (POWCG) Studies Group of the Subseabed Disposal Project (SDP) from October 1984 to termination of the project in May 1986. The overview of the work includes an introduction, general descriptions of the activities, and a summary. Detailed discussions are included as appendices. During the period of this report the POWCG Studies Group held a meeting to develop a long-term research plan for the Nares Abyssal Plain, which was recently designated as a study area for the Environmental Study Group of the SDP. The POWCG Studies Group hasmore » also planned and participated in two interdisciplinary oceanographic missions to the Nares which have resulted in the acquisition of data and samples which can be used to begin to understand the workings of the ecosystem at the site, and for developing a preliminary site assessment. The papers in the appendices have been processed for inclusion in the Energy Data Base.« less

Ikonos Imagery Product Nonuniformity Assessment

NASA Technical Reports Server (NTRS)

Ryan, Robert; Zanoni, Vicki; Pagnutti, Mary; Holekamp, Kara; Smith, Charles

2002-01-01

During the early stages of the NASA Scientific Data Purchase (SDP) program, three approximately equal vertical stripes were observable in the IKONOS imagery of highly spatially uniform sites. Although these effects appeared to be less than a few percent of the mean signal, several investigators requested new imagery. Over time, Space Imaging updated its processing to minimize these artifacts. This however, produced differences in Space Imaging products derived from archive imagery processed at different times. Imagery processed before 2/22/01 is processed with one set of coefficients, while imagery processed after that date requires another set. Space Imaging produces its products from raw imagery, so changes in the ground processing over time can change the delivered digital number (DN) values, even for identical orders of a previously acquired scene. NASA Stennis initiated studies to investigate the magnitude and changes in these artifacts over the lifetime of the system and before and after processing updates.

Establishment of Bacterial Herbicide Degraders in a Rapid Sand Filter for Bioremediation of Phenoxypropionate-Polluted Groundwater

PubMed Central

Feld, Louise; Nielsen, Tue Kjærgaard; Hansen, Lars Hestbjerg; Aamand, Jens

2015-01-01

In this study, we investigated the establishment of natural bacterial degraders in a sand filter treating groundwater contaminated with the phenoxypropionate herbicides (RS)-2-(4-chloro-2-methylphenoxy)propanoic acid (MCPP) and (RS)-2-(2,4-dichlorophenoxy)propanoic acid (DCPP) and the associated impurity/catabolite 4-chlorophenoxypropanoic acid (4-CPP). A pilot facility was set up in a contaminated landfill site. Anaerobic groundwater was pumped up and passed through an aeration basin and subsequently through a rapid sand filter, which is characterized by a short residence time of the water in the filter. For 3 months, the degradation of DCPP, MCPP, and 4-CPP in the sand filter increased to 15 to 30% of the inlet concentration. A significant selection for natural bacterial herbicide degraders also occurred in the sand filter. Using a most-probable-number (MPN) method, we found a steady increase in the number of culturable phenoxypropionate degraders, reaching approximately 5 × 105 degraders per g sand by the end of the study. Using a quantitative PCR targeting the two phenoxypropionate degradation genes, rdpA and sdpA, encoding stereospecific dioxygenases, a parallel increase was observed, but with the gene copy numbers being about 2 to 3 log units higher than the MPN. In general, the sdpA gene was more abundant than the rdpA gene, and the establishment of a significant population of bacteria harboring sdpA occurred faster than the establishment of an rdpA gene-carrying population. The identities of the specific herbicide degraders in the sand filter were assessed by Illumina MiSeq sequencing of 16S rRNA genes from sand filter samples and from selected MPN plate wells. We propose a list of potential degrader bacteria involved in herbicide degradation, including representatives belonging to the Comamonadaceae and Sphingomonadales. PMID:26590282

Applications of Living Fire PRA models to Fire Protection Significance Determination Process in Taiwan

DOE Office of Scientific and Technical Information (OSTI.GOV)

De-Cheng, Chen; Chung-Kung, Lo; Tsu-Jen, Lin

2004-07-01

The living fire probabilistic risk assessment (PRA) models for all three operating nuclear power plants (NPPs) in Taiwan had been established in December 2000. In that study, a scenario-based PRA approach was adopted to systematically evaluate the fire and smoke hazards and associated risks. Using these fire PRA models developed, a risk-informed application project had also been completed in December 2002 for the evaluation of cable-tray fire-barrier wrapping exemption. This paper presents a new application of the fire PRA models to fire protection issues using the fire protection significance determination process (FP SDP). The fire protection issues studied may involvemore » the selection of appropriate compensatory measures during the period when an automatic fire detection or suppression system in a safety-related fire zone becomes inoperable. The compensatory measure can either be a 24-hour fire watch or an hourly fire patrol. The living fire PRA models were used to estimate the increase in risk associated with the fire protection issue in terms of changes in core damage frequency (CDF) and large early release frequency (LERF). In compliance with SDP at-power and the acceptance guidelines specified in RG 1.174, the fire protection issues in question can be grouped into four categories; red, yellow, white and green, in accordance with the guidelines developed for FD SDP. A 24-hour fire watch is suggested only required for the yellow condition, while an hourly fire patrol may be adopted for the white condition. More limiting requirement is suggested for the red condition, but no special consideration is needed for the green condition. For the calculation of risk measures, risk impacts from any additional fire scenarios that may have been introduced, as well as more severe initiating events and fire damages that may accompany the fire protection issue should be considered carefully. Examples are presented in this paper to illustrate the evaluation process. (authors)« less

Empirical parameters for solvent acidity, basicity, dipolarity, and polarizability of the ionic liquids [BMIM][BF4] and [BMIM][PF6].

PubMed

del Valle, J C; García Blanco, F; Catalán, J

2015-04-02

The empirical solvent scales for polarizability (SP), dipolarity (SdP), acidity (SA), and basicity (SB) have been successfully used to interpret the solvatochromism of compounds dissolved in organic solvents and their solvent mixtures. Providing that the published solvatochromic parameters for the ionic liquids 1-(1-butyl)-3-methylimidazolium tetrafluoroborate, [BMIM][BF4] and 1-(1-butyl)-3-methylimidazolium hexafluorophosphate, [BMIM][PF6], are excessively widespread, their SP, SdP, SA, and SB values are measured herein at temperatures from 293 to 353 K. Four key points are emphasized herein: (i) the origin of the solvatochromic solvent scales--the gas phase, that is the absence of any medium perturbation--; (ii) the separation of the polarizability and dipolarity effects; (iii) the simplification of the probing process in order to obtain the solvatochromic parameters; and (iv) the SP, SdP, SA, and SB solvent scales can probe the polarizability, dipolarity, acidity, and basicity of ionic liquids as well as of organic solvents and water-organic solvent mixtures. From the multiparameter approach using the four pure solvent scales one can draw the conclusion that (a) the solvent influence of [BMIM][BF4] parallels that of formamide at 293 K, both of them miscible with water; (b) [BMIM][PF6] shows a set of solvatochromic parameters similar to that of chloroacetonitrile, both of them water insoluble; and (c) that the corresponding solvent acidity and basicity of the ionic liquids can be explained to a great extent from the cation species by comparing the empirical parameters of [BMIM](+) with those of the solvent 1-methylimidazole. The insolubility of [BMIM][PF6] in water as compared to [BMIM][BF4] is tentatively connected to some extent to the larger molar volume of the anion [PF6](-), and to the difference in basicity of [PF6](-) and [BF4](-).

Deleting multiple lytic genes enhances biomass yield and production of recombinant proteins by Bacillus subtilis.

PubMed

Wang, Yi; Chen, Zhenmin; Zhao, Ruili; Jin, Tingting; Zhang, Xiaoming; Chen, Xiangdong

2014-08-31

Bacillus subtilis is widely used in agriculture and industrial biotechnology; however, cell autolysis significantly decreases its yield in liquid cultures. Numerous factors mediate the lysis of B. subtilis, such as cannibalism factors, prophages, and peptidoglycan (PG) hydrolases. The aim of this work was to use molecular genetic techniques to develop a new strategy to prevent cell lysis and enhance biomass as well as the production of recombinant proteins. Five genes or genetic elements representing three different functional categories were studied as follows: lytC encoding PG hydrolases, the prophage genes xpf and yqxG-yqxH-cwlA (yGlA), and skfA and sdpC that encode cannibalism factors. Cell lysis was reduced and biomass was enhanced by deleting individually skfA, sdpC, xpf, and lytC. We constructed the multiple deletion mutant LM2531 (skfA sdpC lytC xpf) and found that after 4 h of culture, its biomass yield was significantly increased compared with that of prototypical B. subtilis 168 (wild-type) strain and that 15% and 92% of the cells were lysed in cultures of LM2531 and wild-type, respectively. Moreover, two expression vectors were constructed for producing recombinant proteins (β-galactosidase and nattokinase) under the control of the P43 promoter. Cultures of LM2531 and wild-type transformants produced 13741 U/ml and 7991 U/ml of intracellular β-galactosidase, respectively (1.72-fold increase). Further, the level of secreted nattokinase produced by strain LM2531 increased by 2.6-fold compared with wild-type (5226 IU/ml vs. 2028 IU/ml, respectively). Our novel, systematic multigene deletion approach designed to inhibit cell lysis significantly increased the biomass yield and the production of recombinant proteins by B. subtilis. These findings show promise for guiding efforts to manipulate the genomes of other B. subtilis strains that are used for industrial purposes.

Analytic Energy Gradients for Variational Two-Electron Reduced-Density-Matrix-Driven Complete Active Space Self-Consistent Field Theory.

PubMed

Maradzike, Elvis; Gidofalvi, Gergely; Turney, Justin M; Schaefer, Henry F; DePrince, A Eugene

2017-09-12

Analytic energy gradients are presented for a variational two-electron reduced-density-matrix (2-RDM)-driven complete active space self-consistent field (CASSCF) method. The active-space 2-RDM is determined using a semidefinite programing (SDP) algorithm built upon an augmented Lagrangian formalism. Expressions for analytic gradients are simplified by the fact that the Lagrangian is stationary with respect to variations in both the primal and the dual solutions to the SDP problem. Orbital response contributions to the gradient are identical to those that arise in conventional CASSCF methods in which the electronic structure of the active space is described by a full configuration interaction (CI) wave function. We explore the relative performance of variational 2-RDM (v2RDM)- and CI-driven CASSCF for the equilibrium geometries of 20 small molecules. When enforcing two-particle N-representability conditions, full-valence v2RDM-CASSCF-optimized bond lengths display a mean unsigned error of 0.0060 Å and a maximum unsigned error of 0.0265 Å, relative to those obtained from full-valence CI-CASSCF. When enforcing partial three-particle N-representability conditions, the mean and maximum unsigned errors are reduced to only 0.0006 and 0.0054 Å, respectively. For these same molecules, full-valence v2RDM-CASSCF bond lengths computed in the cc-pVQZ basis set deviate from experimentally determined ones on average by 0.017 and 0.011 Å when enforcing two- and three-particle conditions, respectively, whereas CI-CASSCF displays an average deviation of 0.010 Å. The v2RDM-CASSCF approach with two-particle conditions is also applied to the equilibrium geometry of pentacene; optimized bond lengths deviate from those derived from experiment, on average, by 0.015 Å when using a cc-pVDZ basis set and a (22e,22o) active space.

Chandra and ALMA observations of the nuclear activity in two strongly lensed star-forming galaxies

NASA Astrophysics Data System (ADS)

Massardi, M.; Enia, A. F. M.; Negrello, M.; Mancuso, C.; Lapi, A.; Vignali, C.; Gilli, R.; Burkutean, S.; Danese, L.; Zotti, G. De

2018-02-01

Aim. According to coevolutionary scenarios, nuclear activity and star formation play relevant roles in the early stages of galaxy formation. We aim at identifying them in high-redshift galaxies by exploiting high-resolution and high-sensitivity X-ray and millimeter-wavelength data to confirm the presence or absence of star formation and nuclear activity and describe their relative roles in shaping the spectral energy distributions and in contributing to the energy budgets of the galaxies. Methods: We present the data, model, and analysis in the X-ray and millimeter (mm) bands for two strongly lensed galaxies, SDP.9 (HATLAS J090740.0-004200) and SDP.11 (HATLAS J091043.1-000322), which we selected in the Herschel-ATLAS catalogs for their excess emission in the mid-IR regime at redshift ≳1.5. This emission suggests nuclear activity in the early stages of galaxy formation. We observed both of them with Chandra ACIS-S in the X-ray regime and analyzed the high-resolution mm data that are available in the ALMA Science Archive for SDP.9. By combining the information available in mm, optical, and X-ray bands, we reconstructed the source morphology. Results: Both targets were detected in the X-ray, which strongly indicates highly obscured nuclear activity. ALMA observations for SDP.9 for the continuum and CO(6-5) spectral line with high resolution (0.02 arcsec corresponding to 65 pc at the distance of the galaxy) allowed us to estimate the lensed galaxy redshift to a better accuracy than pre-ALMA estimates (1.5753 ± 0.0003) and to model the emission of the optical, millimetric, and X-ray band for this galaxy. We demonstrate that the X-ray emission is generated in the nuclear environment, which strongly supports that this object has nuclear activity. On the basis of the X-ray data, we attempt an estimate of the black hole properties in these galaxies. Conclusions: By taking advantage of the lensing magnification, we identify weak nuclear activity associated with high-z galaxies with high star formation rates. This is useful to extend the investigation of the relationship between star formation and nuclear activity to two intrinsically less luminous high-z star-forming galaxies than was possible so far. Given our results for only two objects, they alone cannot constrain the evolutionary models, but provide us with interesting hints and set an observational path toward addressing the role of star formation and nuclear activity in forming galaxies. The reduced images and data cubes as FITS files are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/610/A53

Negotiating a Liberative Pedagogy in Sport Development and Peace: Understanding Consciousness Raising through the Go Sisters Programme in Zambia

ERIC Educational Resources Information Center

Mwaanga, Oscar; Prince, Samantha

2016-01-01

Labelled as an alternative and more representative engine for development [Levermore, R. (2008). "Sport: A new engine of development?" "Progress in Development Studies," 8(2), 183-190. doi: 10.1177/146499340700800204], the international sport development and peace (SDP) movement is under pressure to enhance its credibility and…

The Relationship between Principal Beliefs about Effective Leadership Practices and the Enactment of Those Beliefs Related to Literacy Instruction

ERIC Educational Resources Information Center

Harrison, Sonya Elaine Somerville

2012-01-01

This exploratory study was prompted by mandated curricular change within the School District of Philadelphia (SDP) Empowerment Schools. Empowerment Schools are schools that receive highly targeted instructional and non-instructional resources to improve student learning. Supports and services are concentrated in four areas: instruction, student…

Using a fully recyclable dicarboxylic acid for producing dispersible and thermally stable cellulose nanomaterials from different cellulosic sources

Treesearch

Chao Jia; Liheng Chen; Ziqiang Shao; Umesh P. Agarwal; Liangbing Hu; J. Y. Zhu

2017-01-01

We fabricated cellulose nanocrystals (CNCs) and cellulose nanofibrils (CNFs) from different cellulose materials (bleached eucalyptus pulp (BEP), spruce dissolving pulp (SDP) and cotton based qualitative filter paper (QFP) using concentrated oxalic acid hydrolysis and subsequent mechanical fibrillation (for CNFs). The process was green as acid can easily be recovered,...

Principals' Hiring of Teachers in Philadelphia Schools: A Research Report on Improving Teacher Quality

ERIC Educational Resources Information Center

Ramirez, Heidi A.; Schofield, Lynne Steuerle; Black, Melissa

2009-01-01

The School District of Philadelphia (SDP), like many other urban school districts, struggles to increase its hiring and retention of experienced and highly qualified teachers in its low-performing/high-need schools. Toward the goal of improving teacher quality and the experience balance, particularly in hard-to-staff schools, the Philadelphia…

75 FR 19977 - Office of the Assistant Secretary for Planning and Evaluation; Statement of Organization...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-16

... reorganization is to realign the functions of ASPE's Office of Science and Data Policy to reflect the current... and Data Policy (AEJ),'' in its entirety and replace with the following: E. The Office of Science and Data Policy (AEJ) The Office of Science and Data Policy (SDP) is responsible for policy development...

Successful Researcher-Practitioner RCT Partnership: Increasing Attendance by 15,000 Days

ERIC Educational Resources Information Center

Rogers, Todd; Wolford, Tonya; Reitano, Adrienne; Feller, Avi; Subramanyam, Shruthi; Ternovski, John

2016-01-01

While the adjusted cohort graduation rate of students in the United States has reached 80 percent during the 2011-12 school year (Stetser & Stillwell, 2014), in the School District of Philadelphia (SDP) only 57% of its students graduate from high school in four years, which is typical of large urban school districts (Swanson, 2009). Moreover,…

THE CDF ARCHIVE: HERSCHEL PACS AND SPIRE SPECTROSCOPIC DATA PIPELINE AND PRODUCTS FOR PROTOSTARS AND YOUNG STELLAR OBJECTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, Joel D.; Yang, Yao-Lun; II, Neal J. Evans

2016-03-15

We present the COPS-DIGIT-FOOSH (CDF) Herschel spectroscopy data product archive, and related ancillary data products, along with data fidelity assessments, and a user-created archive in collaboration with the Herschel-PACS and SPIRE ICC groups. Our products include datacubes, contour maps, automated line fitting results, and best 1D spectra products for all protostellar and disk sources observed with PACS in RangeScan mode for two observing programs: the DIGIT Open Time Key Program (KPOT-nevans-1 and SDP-nevans-1; PI: N. Evans), and the FOOSH Open Time Program (OT1-jgreen02-2; PI: J. Green). In addition, we provide our best SPIRE-FTS spectroscopic products for the COPS Open Time Program (OT2-jgreen02-6;more » PI: J. Green) and FOOSH sources. We include details of data processing, descriptions of output products, and tests of their reliability for user applications. We identify the parts of the data set to be used with caution. The resulting absolute flux calibration has improved in almost all cases. Compared to previous reductions, the resulting rotational temperatures and numbers of CO molecules have changed substantially in some sources. On average, however, the rotational temperatures have not changed substantially (<2%), but the number of warm (T{sub rot} ∼ 300 K) CO molecules has increased by about 18%.« less

The CDF Archive: Herschel PACS and SPIRE Spectroscopic Data Pipeline and Products for Protostars and Young Stellar Objects

NASA Astrophysics Data System (ADS)

Green, Joel D.; Yang, Yao-Lun; Evans, Neal J., II; Karska, Agata; Herczeg, Gregory; van Dishoeck, Ewine F.; Lee, Jeong-Eun; Larson, Rebecca L.; Bouwman, Jeroen

2016-03-01

We present the COPS-DIGIT-FOOSH (CDF) Herschel spectroscopy data product archive, and related ancillary data products, along with data fidelity assessments, and a user-created archive in collaboration with the Herschel-PACS and SPIRE ICC groups. Our products include datacubes, contour maps, automated line fitting results, and best 1D spectra products for all protostellar and disk sources observed with PACS in RangeScan mode for two observing programs: the DIGIT Open Time Key Program (KPOT_nevans1 and SDP_nevans_1; PI: N. Evans), and the FOOSH Open Time Program (OT1_jgreen02_2; PI: J. Green). In addition, we provide our best SPIRE-FTS spectroscopic products for the COPS Open Time Program (OT2_jgreen02_6; PI: J. Green) and FOOSH sources. We include details of data processing, descriptions of output products, and tests of their reliability for user applications. We identify the parts of the data set to be used with caution. The resulting absolute flux calibration has improved in almost all cases. Compared to previous reductions, the resulting rotational temperatures and numbers of CO molecules have changed substantially in some sources. On average, however, the rotational temperatures have not changed substantially (<2%), but the number of warm (Trot ∼ 300 K) CO molecules has increased by about 18%.

Short communication: the effect of dry period duration and dietary energy density in early lactation on the rennet gelation properties of milk.

PubMed

Butler, S T; de Feu, M A; O'Brien, B; Guinee, T P; Murphy, J J

2010-02-01

This study was carried out to examine the effects of decreasing the dry period (DP) duration and altering the energy density of the diet during early lactation on the rheological characteristics of milk. Forty mature Holstein-Friesian cows were used in a completely randomized design with a 2 x 2 factorial arrangement of treatments. Cows were randomly assigned to 1 of 2 dry period treatments and 1 of 2 nutritional treatments. The DP treatments were continuous milking (CM) or an 8-wk standard dry period (SDP), and the nutritional treatments were a standard energy diet (SE) or a high energy diet (HE). Actual DP lengths were 6.3+/-1.7 d and 62.1+/-1.9 d for cows on the CM and SDP treatments, respectively. Milk samples were collected at 2, 6, and 10 wk postpartum. The concentrations of fat, protein, and lactose were determined in each sample. The rennet gelation properties were measured at 31 degrees C using dynamic low-amplitude strain oscillatory rheometry. The following parameters were obtained from the resultant elastic shear modulus (G'): gelation time, maximum curd firming rate, and gel strength. Reducing the DP duration from 62 to 6 d resulted in increases in milk protein concentration (31.8 vs. 34.7 g/kg), maximum curd firming rate (2.58 vs. 3.60 Pa/min), and gel strength (69.4 vs. 90.5Pa). Increasing the dietary energy density decreased percentage milk fat (43.1 vs. 37.7 g/kg) but otherwise had no effect. Gel strength was correlated with maximum curd firming rate (r=0.99), and both variables were correlated with milk protein concentration (r=0.71 and r=0.73, respectively). The results indicate that decreasing the duration of the DP increased milk protein concentration and improved the rennet gelation properties of milk, but that dietary energy density had little effect. Copyright 2010 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Earth observing system. Output data products and input requirements, version 2.0. Volume 3: Algorithm summary tables and non-EOS data products

NASA Technical Reports Server (NTRS)

Lu, Yun-Chi; Chang, Hyo Duck; Krupp, Brian; Kumar, Ravindar; Swaroop, Anand

1992-01-01

Volume 3 assists Earth Observing System (EOS) investigators in locating required non-EOS data products by identifying their non-EOS input requirements and providing the information on data sets available at various Distributed Active Archive Centers (DAAC's), including those from Pathfinder Activities and Earth Probes. Volume 3 is intended to complement, not to duplicate, the the EOSDIS Science Data Plan (SDP) by providing detailed data set information which was not presented in the SDP. Section 9 of this volume discusses the algorithm summary tables containing information on retrieval algorithms, expected outputs and required input data. Section 10 describes the non-EOS input requirements of instrument teams and IDS investigators. Also described are the current and future data holdings of the original seven DAACS and data products planned from the future missions and projects including Earth Probes and Pathfinder Activities. Section 11 describes source of information used in compiling data set information presented in this volume. A list of data set attributes used to describe various data sets is presented in section 12 along with their descriptions. Finally, Section 13 presents the SPSO's future plan to improve this report .

Soil cover patterns and SOC dynamics impacts on the soil processes, land management and ecosystem services in Central Region of Russia

NASA Astrophysics Data System (ADS)

Vasenev, Ivan; Chernikov, Vladimir; Yashin, Ivan; Geraskin, Mikhail; Morev, Dmitriy

2014-05-01

In the Central Region of Russia (CRR) the soil cover patterns usually play the very important role in the soil forming and degradation processes (SFP & SDP) potential and current rates, soil organic carbon (SOC) dynamics and pools, greenhouse gases (GHG) emissions and soluble SOC fluxes that we need take into attention for better assessment of the natural and especially man-changed ecosystems' services and for best land-use practices development. Central Region of Russia is the biggest one in RF according to its population and role in the economy. CRR is characterized by high spatial variability of soil cover due to as original landscape heterogeneity as complicated history of land-use practices during last 700 years. Our long-term researches include the wide zonal-provincial set of representative ecosystems and soil cover patterns with different types and history of land-use (forest, meadow-steppe and agricultural ones) from middle-taiga to steppe zones with different level of continentality. The carried out more than 30-years region- and local-scale researches of representative natural and rural landscapes in Tver', Yaroslavl', Kaluga, Moscow, Vladimir, Saransk (Mordovia), Kursk, Orel, Tambov, Voronezh and Saratov oblasts give us the interregional multi-factorial matrix of elementary soil cover patterns (ESCP) with different soil forming and degradation processes rates and soil organic carbon dynamics due to regionally specific soil-geomorphologic features, environmental and dominated microclimate conditions, land-use current practices and history. The validation and ranging of the limiting factors of SFP and SDP develop¬ment, soil carbon dynamics and sequestration potential, ecosystem (agroecosystem) principal services, land functional qualities and agroecological state have been done for dominating and most dynamical components of ESCP regional-typological forms - with application of SOC structure analysis, regional and local GIS, soil spatial patterns detail mapping, traditional regression kriging, correlation tree models and DSS adapted to concrete region and agrolandscape conditions. The outcomes of statistical process modeling show the essential amplification of erosion, dehumification, CO2, CH4 and N2O emission, soluble SOC fluxes, acidification or alkalization, disaggregation and overcompaction processes due to violation of environmentally sound land-use systems and traditional balances of organic matter, nutrients, Ca and Na in agrolandscapes. Due to long-term intensive and out-of-balance land-use practices the most zonal soils and soil cover pattern essentially lost not only their unique natural features (humus horizons depth till 1 m and more in case of Chernozems, 2-6 % of SOC and favorable agrophysical features), but ecosystem services and ecological functions including terrestrial ecosystem carbon balance and the GHG fluxes control. Key-site monitoring results and regional generalized data showed 1-1.5% SOC lost during last 50 years period and active processes of CO2 emission and humus profile eluvial-illuvial redistribution too. A drop of Corg content below threshold "humus limiting content" values (for different soils they vary from 1 to 3-4% of SOC) considerably reduces effectiveness of used fertilizers and possibility of sustai¬nable agronomy here. Forest-steppe Chernozems are usually characterized by higher stability than steppe ones. The ratio between erosive and biological losses in humus supplies can be ten-tatively estimated as fifty-fifty with strong spatial variability due to slope and land-use parameters. These processes have essentially different sets of environmental consequences and ecosystem services that we need to understand in frame of environmental and agroecological problems development prediction.

Reduce Fluid Experiment System: Flight data from the IML-1 Mission

NASA Technical Reports Server (NTRS)

Workman, Gary L.; Harper, Sabrina

1995-01-01

Processing and data reduction of holographic images from the International Microgravity Laboratory 1 (IML-1) presents some interesting challenges in determining the effects of microgravity on crystal growth processes. Use of several processing techniques, including the Computerized Holographic Image Processing System and the Software Development Package (SDP-151) will provide fundamental information for holographic and schlieren analysis of the space flight data.

The Elements of an Effective Software Development Plan - Software Development Process Guidebook

DTIC Science & Technology

2011-11-11

standards and practices required for all XMPL software development. This SDP implements the <corporate> Standard Software Process (SSP). as tailored...Developing and integrating reusable software products • Approach to managing COTS/Reuse software implementation • COTS/Reuse software selection...final selection and submit to change board for approval MAINTENANCE Monitor current products for obsolescence or end of support Track new

20 CFR 1001.123 - Performance standards governing the assignment and role of Local Veterans' Employment...

Code of Federal Regulations, 2010 CFR

2010-04-01

... assigned by each State agency administrator as a full-time or part-time LVER in each SDP in accordance with... need is granted by the ASVET, and (2) At least one part-time LVER whose time shall be devoted to... criteria for full-time LVERs in paragraph (a)(1) of this section. (b) Additional full-time or part-time...

Is a Colectomy Always Just a Colectomy? Additional Procedures as a Proxy for Operative Complexity

PubMed Central

Simmons, Kristina D; Hoffman, Rebecca L; Kuo, Lindsay E; Bartlett, Edmund K; Holena, Daniel N; Kelz, Rachel R

2018-01-01

Background Studies of surgical outcomes can be confounded by operative complexity. Complexity is difficult to assess from claims data due to the absence of established measures, but information on additional procedures is typically available. We hypothesized that analyzing same-day procedures (SDPs) would provide a useful step toward including operative complexity in risk adjustment. Study Design Colon resections were identified in California, Florida, and New York (2008 to 2011). Same-day procedures were categorized using 6 definitions. In-hospital mortality and postoperative complications were examined. For all outcomes, we developed multivariable logistic regression models to measure the association between the SDP category and outcomes. Results Rates of SDP were 74.9% total, 69.5% surgical, 31.6% nonsurgical, 36.6% colon, 51.4% abdomen, and 34.3% other for the 215,041 colon resections examined. Mortality was associated with the inclusion of any SDP category in univariate (6.2% vs 1.7%; p < 0.001) and multivariable (odds ratio [OR] = 2.14; 95% CI, 1.99–2.30; p < 0.001) analysis. The association with mortality was high for nonsurgical (OR = 2.36; 95% CI, 2.26–2.46) and other (OR = 2.33; 95% CI, 2.23–2.43) procedures and moderate for surgical (OR = 1.45; 95% CI, 1.37–1.54) and colon (OR = 1.51; 95% CI, 1.44–1.57) procedures, but abdominal procedures were not independently associated with mortality (OR = 1.01; 95% CI, 0.97–1.06). The total number of SDPs was also associated with higher complication rates. Conclusions The risk of complications and mortality associated with colectomy was increased among patients with SDPs and the magnitude of the association was dependent on the type and quantity of additional procedures. Information on SDPs might reflect a component of operative risk not typically captured and should be considered as a candidate variable for risk adjustment when using claims to compare outcomes across large cohorts. PMID:26228014

The Tupange Project in Kenya: A Multifaceted Approach to Increasing Use of Long-Acting Reversible Contraceptives

PubMed Central

Muthamia, Michael; Owino, Kenneth; Nyachae, Paul; Kilonzo, Margaret; Kamau, Mercy; Otai, Jane; Kabue, Mark; Keyonzo, Nelson

2016-01-01

ABSTRACT Background: Long-acting reversible contraceptives (LARCs) are safe and highly effective, and they have higher continuation rates than short-acting methods. Because only a small percentage of sexually active women in Kenya use LARCs, the Tupange project implemented a multifaceted approach to increase uptake of LARCs, particularly among the urban poor. The project included on-site mentoring, whole-site orientation, commodity security, quality improvement, and multiple demand-promotion and service-provision strategies, in the context of wide method choice. We report on activities in Nairobi between July 2011 and December 2014, the project implementation period. Methods: We used a household longitudinal survey of women of reproductive age to measure changes in the contraceptive prevalence rate (CPR) and other family planning-related variables. At baseline in July 2010, 2,676 women were interviewed; about 50% were successfully tracked and interviewed at endline in December 2014. A baseline service delivery point (SDP) survey of 112 health facilities and 303 service providers was conducted in July 2011, and an endline SDP survey was conducted in December 2014 to measure facility-based interventions. The SDP baseline survey was conducted after the household survey, as facilities were selected based on where clients said they obtained services. Results: The project led to significant increases in use of implants and intrauterine devices (IUDs). Uptake of implants increased by 6.5 percentage points, from 2.4% at baseline to 8.9% by endline, and uptake of IUDs increased by 2.1 percentage points, from 2.2% to 4.3%. By the endline survey, 37.7% of clients using pills and injectables at baseline had switched to LARCs. Contraceptive use among the poorest and poor wealth quintiles increased by 20.5 and 21.5 percentage points, respectively, from baseline to endline. Various myths and misconceptions reported about family planning methods declined significantly between baseline and endline. Conclusion: Training, commodity security, multiple service delivery models, and demand promotion were the cornerstones of a successful approach to reach the urban poor in Nairobi with LARCs. PMID:27540124

OPAL Netlogo Land Condition Model

DTIC Science & Technology

2014-08-15

ER D C/ CE RL T R- 14 -1 2 Optimal Allocation of Land for Training and Non-training Uses ( OPAL ) OPAL Netlogo Land Condition Model...Fulton, Natalie Myers, Scott Tweddale, Dick Gebhart, Ryan Busby, Anne Dain-Owens, and Heidi Howard August 2014 OPAL team measuring above and...online library at http://acwc.sdp.sirsi.net/client/default. Optimal Allocation of Land for Training and Non-training Uses ( OPAL ) ERDC/CERL TR-14-12

School District of Philadelphia Student Achievement as Related to 2008-2009 K-8 Teachers' Perceptions of Major Academic Indicators

ERIC Educational Resources Information Center

Mason-Dorman, Cheryl

2013-01-01

The School District of Philadelphia (SDP), established in 1818, is the eighth largest school district in the United States, with a student enrollment of 184,560 K-12 students. Like most of the other large urban school districts in the United States, its student population consists of more minority students than non-minority students. As the white…

Error Quantification and Confidence Assessment of Aerothermal Model Predictions for Hypersonic Aircraft (Preprint)

DTIC Science & Technology

2013-09-01

based confidence metric is used to compare several different model predictions with the experimental data. II. Aerothermal Model Definition and...whereas 5% measurement uncertainty is assumed for aerodynamic pressure and heat flux measurements 4p y and 4Q y . Bayesian updating according... definitive conclusions for these particular aerodynamic models. However, given the confidence associated with the 4 sdp predictions for Run 30 (H/D

JPRS Report, West Europe.

DTIC Science & Technology

1987-06-29

Congress But LSW Feud Continues (DAGENS NYHETER, various dates) 54 Applauds USSR, Attacks SDP, by Ake Ekdahl 54 Plan for Collective Leadership, by...national economy. National economy, however, requires planning based on the consideration of the commom good. The state must have the ability to guide the...regulation and planning as their counterparts to protect the common weal. It has been said of the many meanings of socialism that "the state has to be

High spatial resolution satellite observations for validation of MODIS land products: IKONOS observations acquired under the NASA scientific data purchase.

Treesearch

Jeffrey T. Morisette; Jaime E. Nickeson; Paul Davis; Yujie Wang; Yuhong Tian; Curtis E. Woodcock; Nikolay Shabanov; Matthew Hansen; Warren B. Cohen; Doug R. Oetter; Robert E. Kennedy

2003-01-01

Phase 1I of the Scientific Data Purchase (SDP) has provided NASA investigators access to data from four different satellite and airborne data sources. The Moderate Resolution Imaging Spectrometer (MODIS) land discipline team (MODLAND) sought to utilize these data in support of land product validation activities with a lbcus on tile EOS Land Validation Core Sites. These...

Deliberating A Contract Type Based Risk Mitigation Strategy For South African Defense Acquisitions

DTIC Science & Technology

2016-06-01

University of Pretoria, South Africa Submitted in partial fulfillment of the Requirements for the degree of MASTER OF BUSINESS ADMINISTRATION...Capability RSA-MIL-STD-3 Military Standard 3 SA South Africa SANDF South African National Defence Force SDP Strategic Defence Package SDR...There are two broad categories of contract types namely, Fixed and Cost reimbursement type contract. The two categories are further divided into more

Multi-objective design optimization of antenna structures using sequential domain patching with automated patch size determination

NASA Astrophysics Data System (ADS)

Koziel, Slawomir; Bekasiewicz, Adrian

2018-02-01

In this article, a simple yet efficient and reliable technique for fully automated multi-objective design optimization of antenna structures using sequential domain patching (SDP) is discussed. The optimization procedure according to SDP is a two-step process: (i) obtaining the initial set of Pareto-optimal designs representing the best possible trade-offs between considered conflicting objectives, and (ii) Pareto set refinement for yielding the optimal designs at the high-fidelity electromagnetic (EM) simulation model level. For the sake of computational efficiency, the first step is realized at the level of a low-fidelity (coarse-discretization) EM model by sequential construction and relocation of small design space segments (patches) in order to create a path connecting the extreme Pareto front designs obtained beforehand. The second stage involves response correction techniques and local response surface approximation models constructed by reusing EM simulation data acquired in the first step. A major contribution of this work is an automated procedure for determining the patch dimensions. It allows for appropriate selection of the number of patches for each geometry variable so as to ensure reliability of the optimization process while maintaining its low cost. The importance of this procedure is demonstrated by comparing it with uniform patch dimensions.

Modeling and system design for the LOFAR station digital processing

NASA Astrophysics Data System (ADS)

Alliot, Sylvain; van Veelen, Martijn

2004-09-01

In the context of the LOFAR preliminary design phase and in particular for the specification of the Station Digital Processing (SDP), a performance/cost model of the system was used. We present here the framework and the trajectory followed in this phase when going from requirements to specification. In the phased array antenna concepts for the next generation of radio telescopes (LOFAR, ATA, SKA) signal processing (multi-beaming and RFI mitigation) replaces the large antenna dishes. The embedded systems for these telescopes are major infrastructure cost items. Moreover, the flexibility and overall performance of the instrument depend greatly on them, therefore alternative solutions need to be investigated. In particular, the technology and the various data transport selections play a fundamental role in the optimization of the architecture. We proposed a formal method [1] of exploring these alternatives that has been followed during the SDP developments. Different scenarios were compared for the specification of the application (selection of the algorithms as well as detailed signal processing techniques) and in the specification of the system architecture (selection of high level topologies, platforms and components). It gave us inside knowledge on the possible trade-offs in the application and architecture domains. This was successful in providing firm basis for the design choices that are demanded by technical review committees.

Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses

PubMed Central

Pappalardo, Morena; Juliá, Miguel; Howard, Mark J.; Rossman, Jeremy S.; Michaelis, Martin; Wass, Mark N.

2016-01-01

Reston viruses are the only Ebolaviruses that are not pathogenic in humans. We analyzed 196 Ebolavirus genomes and identified specificity determining positions (SDPs) in all nine Ebolavirus proteins that distinguish Reston viruses from the four human pathogenic Ebolaviruses. A subset of these SDPs will explain the differences in human pathogenicity between Reston and the other four ebolavirus species. Structural analysis was performed to identify those SDPs that are likely to have a functional effect. This analysis revealed novel functional insights in particular for Ebolavirus proteins VP40 and VP24. The VP40 SDP P85T interferes with VP40 function by altering octamer formation. The VP40 SDP Q245P affects the structure and hydrophobic core of the protein and consequently protein function. Three VP24 SDPs (T131S, M136L, Q139R) are likely to impair VP24 binding to human karyopherin alpha5 (KPNA5) and therefore inhibition of interferon signaling. Since VP24 is critical for Ebolavirus adaptation to novel hosts, and only a few SDPs distinguish Reston virus VP24 from VP24 of other Ebolaviruses, human pathogenic Reston viruses may emerge. This is of concern since Reston viruses circulate in domestic pigs and can infect humans, possibly via airborne transmission. PMID:27009368

Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses.

PubMed

Pappalardo, Morena; Juliá, Miguel; Howard, Mark J; Rossman, Jeremy S; Michaelis, Martin; Wass, Mark N

2016-03-24

Reston viruses are the only Ebolaviruses that are not pathogenic in humans. We analyzed 196 Ebolavirus genomes and identified specificity determining positions (SDPs) in all nine Ebolavirus proteins that distinguish Reston viruses from the four human pathogenic Ebolaviruses. A subset of these SDPs will explain the differences in human pathogenicity between Reston and the other four ebolavirus species. Structural analysis was performed to identify those SDPs that are likely to have a functional effect. This analysis revealed novel functional insights in particular for Ebolavirus proteins VP40 and VP24. The VP40 SDP P85T interferes with VP40 function by altering octamer formation. The VP40 SDP Q245P affects the structure and hydrophobic core of the protein and consequently protein function. Three VP24 SDPs (T131S, M136L, Q139R) are likely to impair VP24 binding to human karyopherin alpha5 (KPNA5) and therefore inhibition of interferon signaling. Since VP24 is critical for Ebolavirus adaptation to novel hosts, and only a few SDPs distinguish Reston virus VP24 from VP24 of other Ebolaviruses, human pathogenic Reston viruses may emerge. This is of concern since Reston viruses circulate in domestic pigs and can infect humans, possibly via airborne transmission.

Prospective comparison of two models of integrating early infant male circumcision with maternal child health services in Kenya: The Mtoto Msafi Mbili Study

PubMed Central

Adera, Fredrick; Mackesy-Amiti, Mary Ellen; Adipo, Timothy; Nordstrom, Sherry K.; Mehta, Supriya D.; Jaoko, Walter; Langi, F. L. Fredrik G.; Obiero, Walter; Obat, Edmon; Otieno, Fredrick O.; Young, Marisa R.

2017-01-01

As countries scale up adult voluntary medical male circumcision (VMMC) for HIV prevention, they are looking ahead to long term sustainable strategies, including introduction of early infant male circumcision (EIMC). To address the lack of evidence regarding introduction of EIMC services in sub-Saharan African settings, we conducted a simultaneous, prospective comparison of two models of EIMC service delivery in Homa Bay County, Kenya. In one division a standard delivery package (SDP) was introduced and included health facility-based provision of EIMC services with community engagement for client referral versus in a different division a standard package plus (SDPplus) that included community-delivered EIMC services. Babies 1–60 days old were eligible for EIMC. A representative sample of mothers and fathers of baby boys at 16 health facilities was surveyed. We examined differences between mothers and fathers in the SDP and SDPplus divisions and identified factors associated with EIMC uptake. We report adjusted prevalence ratios (aPR). Of 1660 mothers interviewed, 1501 (89%) gave approval to contact the father, and 1259 fathers (84%) were interviewed. The proportion of babies circumcised was slightly greater in the SDPplus division than the SDP division (27.3% vs 23.7%), but the difference was not significant (p = 0.08). In adjusted analyses, however, the prevalence of babies being circumcised was greater in the SDPplus division (aPR = 1.23, 95% CI:1.04–1.45) and the factors associated with a baby being circumcised were the mother having received information about EIMC (during pregnancy, aPR = 4.81, 95% CI: 2.21–3.42), having discussed circumcision with the father if married or cohabiting (aPR = 5.39, 95% CI: 3.31–8.80) or being single (aPR = 5.67, 95% CI: 3.31–9.69), perceiving herself to be living with HIV (aPR = 1.39, 95% CI: 1.15–1.67), or having a post-secondary education (aPR = 1.33, 95% CI: 1.04–1.69), and the father being Muslim (aPR = 1.85, 95% CI: 1.29–2.65) or circumcised (aPR = 1.34, 95% CI: 1.13–1.59). The median age of 2117 babies circumcised was 8 days (IQR: 1–36), and the median weight was 3.6 kg (IQR: 3.2–4.4). There were 6 moderate adverse events (AEs) (0.28%); 5 severe AEs (0.24%), all involving an injury to the glans penis, requiring hospitalization and corrective surgery; and one death probably related to the procedure. There were no AEs among the 365 procedures performed outside health facilities. Information and education campaigns must reach members of the general population, especially men and fathers, who are influential to the EIMC decision. Serious AEs using the Mogen clamp are rare, but do occur and require efficient, reliable emergency back-up. Our results can assist countries considering scale-up of EIMC services for HIV prevention as their adult VMMC programs mature. PMID:28880904

Passive correlation ranging of a geostationary satellite using DVB-S payload signals.

NASA Astrophysics Data System (ADS)

Shakun, Leonid; Shulga, Alexandr; Sybiryakova, Yevgeniya; Bushuev, Felix; Kaliuzhnyi, Mykola; Bezrukovs, Vladislavs; Moskalenko, Sergiy; Kulishenko, Vladislav; Balagura, Oleg

2016-07-01

Passive correlation ranging (PaCoRa) for geostationary satellites is now considered as an alternate to tone-ranging (https://artes.esa.int/search/node/PaCoRa). The PaCoRa method has been employed in the Research Institute "Nikolaev astronomical observatory" since the first experiment in August 2011 with two stations spatially separated on 150 km. The PaCoRa has been considered as an independent method for tracking the future Ukrainian geostationary satellite "Lybid'. Now a radio engineering complex (RC) for passive ranging consists of five spatially separated stations of receiving digital satellite television and a data processing center located in Mykolaiv. The stations are located in Kyiv, Kharkiv, Mukacheve, Mykolaiv (Ukraine) and in Ventspils (Latvia). Each station has identical equipment. The equipment allows making synchronous recording of fragments of the DVB-S signal from the quadrature detector output of a satellite television receiver. The fragments are recorded every second. Synchronization of the stations is performed using GPS receivers. Samples of the complex signal obtained in this way are archived and are sent to the data processing center over the Internet. Here the time differences of arrival (TDOA) for pairs of the stations are determined as a result of correlation processing of received signals. The values of the TDOA that measured every second are used for orbit determination (OD) of the satellite. The results of orbit determination of the geostationary telecommunication satellite "Eutelsat-13B" (13º East) obtained during about four months of observations in 2015 are presented in the report. The TDOA and OD accuracies are also given. Single-measurement error (1 sigma) of the TDOA is equal about 8.7 ns for all pairs of the stations. Standard deviations and average values of the residuals between the observed TDOA and the TDOA computed using the orbit elements obtained from optical measurements are estimated for the pairs Kharkiv-Mykolaiv and Mukacheve-Mykolaiv. The standard deviations do not exceed 10 ns for the both pairs and the average values are equal +10 ns and -106 ns respectively for Kharkiv-Mykolaiv and Mukacheve-Mykolaiv. We discuss the residuals between the observed TDOA and estimates of the TDOA that are calculated by fitted models of satellite motion: the SGP4/SDP4 model and the model based on the numerical integration of the equations of motion taking into account the geopotential, and the perturbation from the Moon and the Sun. We note that residuals from the model SGP4/SDP4 have periodic deviations due to the inaccuracy of the SGP4/SDP4 model. As a result, estimation of the standard deviation of the satellite position is about 60 m for the epoch of the SGP4/SDP4 orbit elements. The residuals for the numerical model in the interval of one day do not show low-frequency deviation. In this case, the estimate of the standard deviation of the satellite position is about 12 m for the epoch of the numerical orbit elements. Keywords. DVB-S, geostationary satellite, orbit determination, passive ranging.

JPRS Report, West Europe.

DTIC Science & Technology

1988-09-29

Business Leaders Finds Most Favor Broad Coalition 7 Finnish Scholar-Diplomat, SPIEGEL Staffer Hit ’Finlandization’ Term 10 Korhonen: Term Erroneous 10...in the Government"] [Text] The VU [Volksunie] is being touched up inside and out. Painters are busy at work putting a fresh coat of paint on party...point of view of the SDP, a stand that would be consistent with principles is to press for refusal to do any business with the present Chilean

Identifying Fossil Shell Resources via Geophysical Surveys: Chesapeake Bay Region, Virginia

DTIC Science & Technology

2016-05-01

ER D C/ CH L TR -1 6- 4 Chesapeake Fossil Shell Survey Identifying Fossil Shell Resources via Geophysical Surveys: Chesapeake Bay Region...other technical reports published by ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/client/default. Chesapeake Fossil Shell...Survey ERDC/CHL TR-16-4 May 2016 Identifying Fossil Shell Resources via Geophysical Surveys: Chesapeake Bay Region, Virginia Heidi M. Wadman and Jesse

Sustainability-Related Publications: Calendar Years 2014 - 2015

DTIC Science & Technology

2016-03-03

five 100 kW wind turbines . The best performing turbine assessed at a hub height of 37 m could provide 52% of the site’s annual electric power needs...with a payback of approxi- mately 18 to 19.6 years. However, extrapo- lated long-term wind speeds suggest the best performing turbine assessed could... Wind Resource Assessment: Center Strafford Training Center, http://acwc.sdp.sirsi.net/client/search/asset/1047667 The New Hampshire Army National

Geophysical Survey of McMurdo Ice Shelf to Determine Infrastructure Stability and for Future Planning

DTIC Science & Technology

2017-01-01

ER D C/ CR RE L TR -1 7- 2 Engineering for Polar Operations, Logistics, and Research (EPOLAR) Geophysical Survey of McMurdo Ice Shelf...Army Engineer Research and Development Center (ERDC) solves the nation’s toughest engineering and environmental challenges. ERDC develops...ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/client/default. Engineering for Polar Operations, Logistics, and Research (EPOLAR

Atmospheric Propagation of High Energy Lasers: Modeling, Simulation, Tracking, and Control

DTIC Science & Technology

2008-04-29

the North American Aerospace Defense Command (NORAD) SGP4 /SDP4 orbital propagator and study on energy transfer to orbital assets. • Implementation of...scenarios which include orbital assets. We have incorporated into SHaRE the North American Aerospace Defense Command (NORAD) SGP4 (for near-earth... TLE ) datum. This allows us to investigate the energy characteristics of a ground based laser to an orbital asset. We have conducted a study using

Characterization and prediction of residues determining protein functional specificity.

PubMed

Capra, John A; Singh, Mona

2008-07-01

Within a homologous protein family, proteins may be grouped into subtypes that share specific functions that are not common to the entire family. Often, the amino acids present in a small number of sequence positions determine each protein's particular functional specificity. Knowledge of these specificity determining positions (SDPs) aids in protein function prediction, drug design and experimental analysis. A number of sequence-based computational methods have been introduced for identifying SDPs; however, their further development and evaluation have been hindered by the limited number of known experimentally determined SDPs. We combine several bioinformatics resources to automate a process, typically undertaken manually, to build a dataset of SDPs. The resulting large dataset, which consists of SDPs in enzymes, enables us to characterize SDPs in terms of their physicochemical and evolutionary properties. It also facilitates the large-scale evaluation of sequence-based SDP prediction methods. We present a simple sequence-based SDP prediction method, GroupSim, and show that, surprisingly, it is competitive with a representative set of current methods. We also describe ConsWin, a heuristic that considers sequence conservation of neighboring amino acids, and demonstrate that it improves the performance of all methods tested on our large dataset of enzyme SDPs. Datasets and GroupSim code are available online at http://compbio.cs.princeton.edu/specificity/. Supplementary data are available at Bioinformatics online.

Adenovirus and Norovirus Contaminants in Commercially Distributed Shellfish.

PubMed

Rodriguez-Manzano, Jesus; Hundesa, Ayalkibet; Calgua, Byron; Carratala, Anna; Maluquer de Motes, Carlos; Rusiñol, Marta; Moresco, Vanessa; Ramos, Ana Paula; Martínez-Marca, Fernando; Calvo, Miquel; Monte Barardi, Celia Regina; Girones, Rosina; Bofill-Mas, Sílvia

2014-03-01

Shellfish complying with European Regulations based on quantification of fecal bacterial indicators (FIB) are introduced into markets; however, information on viruses, more stable than FIB, is not available in the literature. To assess the presence of noroviruses (NoVs) GI and GII and human adenoviruses (HAdV) in domestic and imported mussels and clams (n = 151) their presence was analyzed during winter seasons (2004-2008) in north-west Spanish markets through a routine surveillance system. All samples tested negative for NoV GI and 13 % were positive for NoV GII. The role of HAdV as viral indicator was evaluated in 20 negative and 10 positive NoV GII samples showing an estimated sensitivity and specificity of HAdV to predict the presence of NoV GII of 100 and 74 % (cut-off 0.5). The levels of HAdV and NoVs and the efficiency of decontamination in shellfish depuration plants (SDP) were evaluated analyzing pre- and post-depurated mussels collected in May-June 2010 from three different SDP. There were no statistically significant differences in the prevalence and quantification of HAdV between pre- and post-depurated shellfish and between seawater entering and leaving the depuration systems. Moreover, infectious HAdV were detected in depurated mussels. These results confirm previous studies showing that current controls and depuration treatments limiting the number of FIB do not guarantee the absence of viruses in shellfish.

Prediction of a common beta-propeller catalytic domain for fructosyltransferases of different origin and substrate specificity.

PubMed

Pons, T; Hernández, L; Batista, F R; Chinea, G

2000-11-01

The three-dimensional (3D) structure of fructan biosynthetic enzymes is still unknown. Here, we have explored folding similarities between reported microbial and plant enzymes that catalyze transfructosylation reactions. A sequence-structure compatibility search using TOPITS, SDP, 3D-PSSM, and SAM-T98 programs identified a beta-propeller fold with scores above the confidence threshold that indicate a structurally conserved catalytic domain in fructosyltransferases (FTFs) of diverse origin and substrate specificity. The predicted fold appeared related to that of neuraminidase and sialidase, of glycoside hydrolase families 33 and 34, respectively. The most reliable structural model was obtained using the crystal structure of neuraminidase (Protein Data Bank file: 5nn9) as template, and it is consistent with the location of previously identified functional residues of bacterial levansucrases (Batista et al., 1999; Song & Jacques, 1999). The sequence-sequence analysis presented here reinforces the recent inclusion of fungal and plant FTFs into glycoside hydrolase family 32, and suggests a modified sequence pattern H-x (2)-[PTV]-x (4)-[LIVMA]-[NSCAYG]-[DE]-P-[NDSC][GA]3 for this family.

Prediction of a common beta-propeller catalytic domain for fructosyltransferases of different origin and substrate specificity.

PubMed Central

Pons, T.; Hernández, L.; Batista, F. R.; Chinea, G.

2000-01-01

The three-dimensional (3D) structure of fructan biosynthetic enzymes is still unknown. Here, we have explored folding similarities between reported microbial and plant enzymes that catalyze transfructosylation reactions. A sequence-structure compatibility search using TOPITS, SDP, 3D-PSSM, and SAM-T98 programs identified a beta-propeller fold with scores above the confidence threshold that indicate a structurally conserved catalytic domain in fructosyltransferases (FTFs) of diverse origin and substrate specificity. The predicted fold appeared related to that of neuraminidase and sialidase, of glycoside hydrolase families 33 and 34, respectively. The most reliable structural model was obtained using the crystal structure of neuraminidase (Protein Data Bank file: 5nn9) as template, and it is consistent with the location of previously identified functional residues of bacterial levansucrases (Batista et al., 1999; Song & Jacques, 1999). The sequence-sequence analysis presented here reinforces the recent inclusion of fungal and plant FTFs into glycoside hydrolase family 32, and suggests a modified sequence pattern H-x (2)-[PTV]-x (4)-[LIVMA]-[NSCAYG]-[DE]-P-[NDSC][GA]3 for this family. PMID:11305239

Investigation of the Corrosion Mechanism and Determination of the EMS Estimated Service Life at Site 81

DTIC Science & Technology

2013-02-01

nitric acid (HNO3 at 1:1 with deionized H2O). Solu- tions were then filtered and stored in vials. Chloride content analysis was performed using ion...ER D C SR -1 3- 1 Investigation of the Corrosion Mechanism and Determination of the EMS Estimated Service Life at Site 81 En gi ne er...at http://acwc.sdp.sirsi.net/client/default. ERDC SR-13-1 February 2013 Investigation of the Corrosion Mechanism and Determination of the

The Ostrovsky-Vakhnenko equation by a Riemann-Hilbert approach

NASA Astrophysics Data System (ADS)

Boutet de Monvel, Anne; Shepelsky, Dmitry

2015-01-01

We present an inverse scattering transform (IST) approach for the (differentiated) Ostrovsky-Vakhnenko equation This equation can also be viewed as the short wave model for the Degasperis-Procesi (sDP) equation. Our IST approach is based on an associated Riemann-Hilbert problem, which allows us to give a representation for the classical (smooth) solution, to get the principal term of its long time asymptotics, and also to describe loop soliton solutions. Dedicated to Johannes Sjöstrand with gratitude and admiration.

Spectral Assessment of Soil Properties: Standoff Quantification of Soil Organic Matter Content in Surface Mineral Soils and Alaskan Peat

DTIC Science & Technology

2017-08-01

ER D C TR -1 7- 9 ERDC 6.1 Geospatial Research and Engineering (GRE) and ERDC 6.2 GRE ARTEMIS STO-R DRTSPORE Spectral Assessment of...The U.S. Army Engineer Research and Development Center (ERDC) solves the nation’s toughest engineering and environmental challenges. ERDC...published by ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/client/default. ERDC 6.1 Geospatial Research and Engineering (GRE) and

Subjective Mapping of Dust Emission Sources by Using MODIS Imagery: Reproducibility Assessment

DTIC Science & Technology

2017-05-31

ER D C/ CR RE L TR -1 7- 8 ERDC 6.2 Geospatial Research and Engineering (GRE) ARTEMIS STO-R DUST-CLOUD Subjective Mapping of Dust...N. Sinclair and Sandra L. Jones May 2017 Approved for public release; distribution is unlimited. The U.S. Army Engineer Research and...library at http://acwc.sdp.sirsi.net/client/default. ERDC 6.2 Geospatial Research and Engineering (GRE) ARTEMIS STO-R DUST-CLOUD ERDC/CRREL TR-17-8

Acquisition of Earth Science Remote Sensing Observations from Commercial Sources: Lessons Learned from the Space Imaging IKONOS Example

NASA Technical Reports Server (NTRS)

Goward, Samuel N.; Townshend, John R.; Zanoni, Vicki; Policelli, Fritz; Stanley, Tom; Ryan, Robert; Holekamp, Kara; Underwood, Lauren; Pagnutti, Mary; Fletcher, Rose

2003-01-01

In an effort to more full explore the potential of commercial remotely sensed land data sources, the NASA Earth Science Enterprise (ESE) implemented an experimental Scientific Data Purchase (SDP) that solicited bids from the private sector to meet ESE-user data needs. The images from the Space Imaging IKONOS system provided a particularly good match to the current ESE missions such as Terra and Landsat 7 and therefore serve as a focal point in this analysis.

High-Bandwidth Tactical-Network Data Analysis in a High-Performance-Computing (HPC) Environment: Voice Call Analysis

DTIC Science & Technology

2015-09-01

Gateway 2 4. Voice Packet Flow: SIP , Session Description Protocol (SDP), and RTP 3 5. Voice Data Analysis 5 6. Call Analysis 6 7. Call Metrics 6...analysis processing is designed for a general VoIP system architecture based on Session Initiation Protocol ( SIP ) for negotiating call sessions and...employs Skinny Client Control Protocol for network communication between the phone and the local CallManager (e.g., for each dialed digit), SIP

The Arms Control and Crisis Management Potential of the Proposed International Satellite Monitoring Agency (ISMA)

DTIC Science & Technology

1984-12-01

unbiased scientific method , is widespread in the West. This is particularly true of the two arms control functions to which an ISMA would contribute...Elizabeth Young (Lord and Lady Kennett), Neitber Red Nor Dead:_ The Case for Dis• aumAmjeif, Social Democratic Party (SDP), Open Forum Paper No. 2...in the national interest. The Soviet Union is not the first, and is unlikely to be the last, country to adopt a . narrow, constructionist approach to

Pharmacotherapeutic education through problem based learning and its impact on cognitive and motivational attitude of Indian students.

PubMed

Chandra, D; Sharma, S; Sethi, G; Dkhar, S

1996-01-01

The cognitive and motivational attitudes to problem based learning (i.e., simple didactic problem stated in written form and Programmed Patient) has been compared with those to didactic lectures (DL), the traditional teaching method. The change in recall performance measured in MCQ tests was considered as a change in the cognitive domain. The first test was conducted one week after completion of the topic and second test was taken 3 months later, without prior information. The motivational change was recorded by open-ended questions about the learning method. Three groups of students at second MBBS professional year level consisting of 55, 57 and 59 people, were assigned a simple didactic problem stated in written form (SDP), programmed patients (PP), and didactic lecture (DL), respectively. The average scores obtained by the learners in problem based learning (PBL) groups were similar to the students in the DL group in both the tests. Most of the students in PBL groups appreciated the exercise and suggested including more such exercises in the curriculum. These exercises helped them to better understand patient problems and prescribing behaviour as well as in development of communication skills. However, these exercises were time consuming and were not examination oriented. Pharmacotherapeutic teaching through PBL could be used within a traditional curriculum to develop relevant and rational use of drugs, provided the evaluation method was also modified.

Stochastic control approaches for sensor management in search and exploitation

NASA Astrophysics Data System (ADS)

Hitchings, Darin Chester

Recent improvements in the capabilities of autonomous vehicles have motivated their increased use in such applications as defense, homeland security, environmental monitoring, and surveillance. To enhance performance in these applications, new algorithms are required to control teams of robots autonomously and through limited interactions with human operators. In this dissertation we develop new algorithms for control of robots performing information-seeking missions in unknown environments. These missions require robots to control their sensors in order to discover the presence of objects, keep track of the objects, and learn what these objects are, given a fixed sensing budget. Initially, we investigate control of multiple sensors, with a finite set of sensing options and finite-valued measurements, to locate and classify objects given a limited resource budget. The control problem is formulated as a Partially Observed Markov Decision Problem (POMDP), but its exact solution requires excessive computation. Under the assumption that sensor error statistics are independent and time-invariant, we develop a class of algorithms using Lagrangian Relaxation techniques to obtain optimal mixed strategies using performance bounds developed in previous research. We investigate alternative Receding Horizon (RH) controllers to convert the mixed strategies to feasible adaptive-sensing strategies and evaluate the relative performance of these controllers in simulation. The resulting controllers provide superior performance to alternative algorithms proposed in the literature and obtain solutions to large-scale POMDP problems several orders of magnitude faster than optimal Dynamic Programming (DP) approaches with comparable performance quality. We extend our results for finite action, finite measurement sensor control to scenarios with moving objects. We use Hidden Markov Models (HMMs) for the evolution of objects, according to the dynamics of a birth-death process. We develop a new lower bound on the performance of adaptive controllers in these scenarios, develop algorithms for computing solutions to this lower bound, and use these algorithms as part of a RH controller for sensor allocation in the presence of moving objects We also consider an adaptive Search problem where sensing actions are continuous and the underlying measurement space is also continuous. We extend our previous hierarchical decomposition approach based on performance bounds to this problem and develop novel implementations of Stochastic Dynamic Programming (SDP) techniques to solve this problem. Our algorithms are nearly two orders of magnitude faster than previously proposed approaches and yield solutions of comparable quality. For supervisory control, we discuss how human operators can work with and augment robotic teams performing these tasks. Our focus is on how tasks are partitioned among teams of robots and how a human operator can make intelligent decisions for task partitioning. We explore these questions through the design of a game that involves robot automata controlled by our algorithms and a human supervisor that partitions tasks based on different levels of support information. This game can be used with human subject experiments to explore the effect of information on quality of supervisory control.

The impact of regional culture on intensive care end of life decision making: an Israeli perspective from the ETHICUS study.

PubMed

Ganz, F D; Benbenishty, J; Hersch, M; Fischer, A; Gurman, G; Sprung, C L

2006-04-01

Decisions of patients, families, and health care providers about medical care at the end of life depend on many factors, including the societal culture. A pan-European study was conducted to determine the frequency and types of end of life practices in European intensive care units (ICUs), including those in Israel. Several results of the Israeli subsample were different to those of the overall sample. The objective of this article was to explore these differences and provide a possible explanation based on the impact of culture on end of life decision making. All adult patients admitted consecutively to three Israeli ICUs (n = 2778) who died or underwent any limitation of life saving interventions between 1 January 1999 and 30 June 2000 were studied prospectively (n = 363). These patients were compared with a similar sample taken from the larger study (ethics in European intensive care units: ETHICUS) carried out in 37 European ICUs. Patients were followed until discharge, death, or 2 months from the decision to limit therapy. End of life decisions were prospectively organised into one of five mutually exclusive categories: cardiopulmonary resuscitation (CPR), brain death, withholding treatment, withdrawing treatment, and active shortening of the dying process (SDP). The data also included patient characteristics (gender, age, ICU admission diagnosis, chronic disorders, date of hospital admission, date and time of decision to limit therapy, date of hospital discharge, date and time of death in hospital), specific therapies limited, and the method of SDP. The majority of patients (n = 252, 69%) had treatment withheld, none underwent SDP, 62 received CPR (17%), 31 had brain death (9%), and 18 underwent withdrawal of treatment (5%). The primary reason given for limiting treatment was that the patient was unresponsive to therapy (n = 187). End of life discussions were held with 132 families (36%), the vast majority of which revolved around withholding treatment (91% of the discussions) and the remainder concerned withdrawing treatment (n = 11, 9%). There was a statistically significant association (chi2 = 830.93, df = 12, p < 0.0001) between the type of end of life decision and region-that is, the northern region of Europe, the central region, the southern region, and Israel. Regional culture plays an important part in end of life decision making. Differences relating to end of life decision making exist between regions and these differences can often be attributed to cultural factors. Such cultures not only affect patients and their families but also the health care workers who make and carry out such decisions.

Assessing the contraceptive supply environment in Kinshasa, DRC: trend data from PMA2020.

PubMed

Babazadeh, S; Lea, S; Kayembe, P; Akilimali, P; Eitmann, L; Anglewicz, P; Bertrand, J

2018-03-01

Performance Monitoring and Accountability 2020 (PMA2020) is a population-based and facility-based survey program conducted in 11 countries to track contraceptive use dynamics and the supply environment. Annual data collection provides trend data unavailable from any other source. Two-stage cluster sampling was used to select 58 enumeration areas in Kinshasa; data were collected in 2014, 2015 and 2016 from three to six service delivery points (SDPs) per EA. Of the 228-248 SDPs surveyed each year, only two-thirds reported to offer family planning (FP) services. Of those reporting to offer FP, one-fifth or more did not do so on the day of the survey. As of 2016, only one-half of SDPs offering FP had at least three methods available, a proxy for contraceptive choice; only one in five had at least five methods. Long-acting reversible contraceptives, including implants and IUDs, were less widely offered and more often stocked out than resupply methods, including condoms, pills and injectables. Contraceptive stockouts were rampant: in 2016, over a quarter of the SDPs experienced stockouts of all methods (except condoms) in the previous 3 months, and two of the three most widely used methods-implants and injectables-were also the most likely to be stocked out. The findings documented the inconsistency in pricing of methods across facilities; moreover, less than one quarter of SDPs posted prices. Patterns in the contraceptive supply environment remained relatively unchanged between 2014 and 2016. The PMA2020 SDP module provides timely, actionable information to the DRC government, FP implementing organizations and donors involved in FP service delivery in Kinshasa, DRC. Yet the value of this information will be determined by the ability of the local FP stakeholders to use it in bringing the needed improvements identified by this survey to the contraceptive supply environment. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America.

Assessing the contraceptive supply environment in Kinshasa, DRC: trend data from PMA2020

PubMed Central

Babazadeh, S; Lea, S; Kayembe, P; Akilimali, P; Eitmann, L; Anglewicz, P; Bertrand, J

2018-01-01

Abstract Performance Monitoring and Accountability 2020 (PMA2020) is a population-based and facility-based survey program conducted in 11 countries to track contraceptive use dynamics and the supply environment. Annual data collection provides trend data unavailable from any other source. Two-stage cluster sampling was used to select 58 enumeration areas in Kinshasa; data were collected in 2014, 2015 and 2016 from three to six service delivery points (SDPs) per EA. Of the 228–248 SDPs surveyed each year, only two-thirds reported to offer family planning (FP) services. Of those reporting to offer FP, one-fifth or more did not do so on the day of the survey. As of 2016, only one-half of SDPs offering FP had at least three methods available, a proxy for contraceptive choice; only one in five had at least five methods. Long-acting reversible contraceptives, including implants and IUDs, were less widely offered and more often stocked out than resupply methods, including condoms, pills and injectables. Contraceptive stockouts were rampant: in 2016, over a quarter of the SDPs experienced stockouts of all methods (except condoms) in the previous 3 months, and two of the three most widely used methods—implants and injectables—were also the most likely to be stocked out. The findings documented the inconsistency in pricing of methods across facilities; moreover, less than one quarter of SDPs posted prices. Patterns in the contraceptive supply environment remained relatively unchanged between 2014 and 2016. The PMA2020 SDP module provides timely, actionable information to the DRC government, FP implementing organizations and donors involved in FP service delivery in Kinshasa, DRC. Yet the value of this information will be determined by the ability of the local FP stakeholders to use it in bringing the needed improvements identified by this survey to the contraceptive supply environment. PMID:29136172

SDP_mharwit_1: Demonstration of HIFI Linear Polarization Analysis of Spectral Features

NASA Astrophysics Data System (ADS)

Harwit, M.

2010-03-01

We propose to observe the polarization of the 621 GHz water vapor maser in VY Canis Majoris to demonstrate the capability of HIFI to make polarization observations of Far-Infrared/Submillimeter spectral lines. The proposed Demonstration Phase would: - Show that HIFI is capable of interesting linear polarization measurements of spectral lines; - Test out the highest spectral resolving power to sort out closely spaced Doppler components; - Determine whether the relative intensities predicted by Neufeld and Melnick are correct; - Record the degree and direction of linear polarization for the closely-Doppler shifted peaks.

Semiconductor radiation detector with internal gain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Iwanczyk, Jan; Patt, Bradley E.; Vilkelis, Gintas

An avalanche drift photodetector (ADP) incorporates extremely low capacitance of a silicon drift photodetector (SDP) and internal gain that mitigates the surface leakage current noise of an avalanche photodetector (APD). The ADP can be coupled with scintillators such as CsI(Tl), NaI(Tl), LSO or others to form large volume scintillation type gamma ray detectors for gamma ray spectroscopy, photon counting, gamma ray counting, etc. Arrays of the ADPs can be used to replace the photomultiplier tubes (PMTs) used in conjunction with scintillation crystals in conventional gamma cameras for nuclear medical imaging.

Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells.

PubMed

Sugimoto, Asuna; Miyazaki, Aya; Kawarabayashi, Keita; Shono, Masayuki; Akazawa, Yuki; Hasegawa, Tomokazu; Ueda-Yamaguchi, Kimiko; Kitamura, Takamasa; Yoshizaki, Keigo; Fukumoto, Satoshi; Iwamoto, Tsutomu

2017-12-18

The extracellular environment regulates the dynamic behaviors of cells. However, the effects of hydrostatic pressure (HP) on cell fate determination of mesenchymal stem cells (MSCs) are not clearly understood. Here, we established a cell culture chamber to control HP. Using this system, we found that the promotion of osteogenic differentiation by HP is depend on bone morphogenetic protein 2 (BMP2) expression regulated by Piezo type mechanosensitive ion channel component 1 (PIEZO1) in MSCs. The PIEZO1 was expressed and induced after HP loading in primary MSCs and MSC lines, UE7T-13 and SDP11. HP and Yoda1, an activator of PIEZO1, promoted BMP2 expression and osteoblast differentiation, whereas inhibits adipocyte differentiation. Conversely, PIEZO1 inhibition reduced osteoblast differentiation and BMP2 expression. Furthermore, Blocking of BMP2 function by noggin inhibits HP induced osteogenic maker genes expression. In addition, in an in vivo model of medaka with HP loading, HP promoted caudal fin ray development whereas inhibition of piezo1 using GsMTx4 suppressed its development. Thus, our results suggested that PIEZO1 is responsible for HP and could functions as a factor for cell fate determination of MSCs by regulating BMP2 expression.

Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion

PubMed Central

Alagdar, Gada Sulaiman A.; Oo, May Kyaw; Sengupta, Pinaki; Mandal, Uttam Kumar; Jaffri, Julian Md.; Chatterjee, Bappaditya

2017-01-01

Background and Objective: One of the established strategies to improve solubility and dissolution rate of poorly water-soluble drugs is solid dispersion (SD). Polyethylene glycol (PEG) is used as common carrier despite its stability problem which may be overcome by the addition of hydrophobic polymer. The present research aimed to develop an SD formulation with ibuprofen, a poor water-soluble BCS Class II drug as active pharmaceutical ingredient (API) and PEG 4000-ethyl cellulose (EC) as binary carrier. Methods: Melt mixing SD method was employed using a ratio of API: binary carrier (1:3.5 w/w) (SDPE). Another SD was prepared using only PEG (SDP) as a carrier for comparative study. The developed formulation was evaluated using optical microscopy, scanning electron microscopy (SEM), determination of moisture content, differential scanning calorimetry (DSC), in vitro dissolution test, attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) and flow properties. Results: SEM and DSC indicated the conversion of crystalline ibuprofen to fine partly amorphous solid dispersion, which was responsible for the increase in dissolution rate of SD than a physical mixture. The release characteristics within 1 h from the higher to the lower value were the SDPE> SDP> physical mixture. Flow property evaluation using the angle of repose showed no difference between SD and PM. However, by Carr index and Hausner ratio, the flow properties of SDPE was excellent. Conclusion: The SD formulation with the PEG 4000-EC carrier can be effective to enhance in vitro dissolution of ibuprofen immediate release dosage form. PMID:29184827

Expectancies, working alliance, and outcome in transdiagnostic and single diagnosis treatment for anxiety disorders: An investigation of mediation.

PubMed

Sauer-Zavala, Shannon; Boswell, James F; Bentley, Kate H; Thompson-Hollands, Johanna; Farchione, Todd J; Barlow, David H

2018-04-01

Patients' outcome expectancies and the working alliance are two psychotherapy process variables that researchers have found to be associated with treatment outcome, irrespective of treatment approach and problem area. Despite this, little is known about the mechanisms accounting for this association, and whether contextual factors (e.g., psychotherapy type) impact the strength of these relationships. The primary aim of this study was to examine whether patient-rated working alliance quality mediates the relationship between outcome expectancies and pre- to post-treatment change in anxiety symptoms using data from a recent randomized clinical trial comparing a transdiagnostic treatment (the Unified Protocol [UP]; Barlow et al., 2011a; Barlow, Sauer-Zavala, et al., in press) to single diagnosis protocols (SDPs) for patients with a principal heterogeneous anxiety disorder ( n = 179). The second aim was to explore whether cognitive-behavioral treatment condition (UP versus SDP) moderated this indirect relationship. Results from mediation and moderated mediation models indicated that, when collapsing across the two treatment conditions, the relationship between expectancies and outcome was partially mediated by the working alliance ( B = .037, SE = .05, 95% CI [.005, .096]). Interestingly, within-condition analyses showed that this conditional indirect effect was only present for SDP patients, whereas in the UP condition, working alliance did not account for the association between expectancies and outcome. These findings suggest that outcome expectancies and working alliance quality may interact to influence treatment outcomes, and that the nature and strength of the relationships among these constructs may differ as a function of the specific cognitive-behavioral treatment approach utilized.

Dipolarity versus polarizability and acidity versus basicity of ionic liquids as a function of their molecular structures.

PubMed

Schade, Alexander; Behme, Nicole; Spange, Stefan

2014-02-17

The four empirical solvent polarity parameters according to the Catalán scale--solvent acidity (SA), solvent basicity (SB), solvent polarizability (SP), and solvent dipolarity (SdP)--of 64 ionic liquids (ILs) were determined by the solvatochromic method. The SA parameter was determined solely by using [Fe(II)(1,10-phenanthroline)2(CN)2] (Fe), the SB parameter by using the pair of structurally comparable dyes 3-(4-amino-3-methylphenyl)-7-phenylbenzo[1,2-b:4,5-b']difuran-2,6-dione (ABF) and 3-(4-N,N-dimethylaminophenyl)-7-phenylbenzo[1,2-b:4,5-b']-difuran-2,6-dione (DMe-ABF), and the SP and SdP parameters by using the homomorphic pair of 4-tert-butyl-2-(dicyanomethylene)-5-[4-(diethylamino)benzylidene]-Δ(3)-thiazoline (Th) and 2-[4-(N,N-dimethylamino)benzylidene]malononitrile (BMN). The separation of SP and SdP for a set of 64 various ILs was performed for the first time. Correlation analyses of SP with physicochemical data related to ionization potentials of anions of ILs as well as with theoretical data show the correctness of the applied method. The found correlations of the Catalán parameters with each other and with the alkyl-chain length of 1-alkyl-3-methylimidazolium-type ILs gives new information about interactions within ILs. An analytical comparison of the determined Catalán parameters with the established Kamlet-Taft parameters and the Gutmann acceptor and donor numbers is also presented. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Square Kilometre Array Science Data Processing

NASA Astrophysics Data System (ADS)

Nikolic, Bojan; SDP Consortium, SKA

2014-04-01

The Square Kilometre Array (SKA) is planned to be, by a large factor, the largest and most sensitive radio telescope ever constructed. The first phase of the telescope (SKA1), now in the design phase, will in itself represent a major leap in capabilities compared to current facilities. These advances are to a large extent being made possible by advances in available computer processing power so that that larger numbers of smaller, simpler and cheaper receptors can be used. As a result of greater reliance and demands on computing, ICT is becoming an ever more integral part of the telescope. The Science Data Processor is the part of the SKA system responsible for imaging, calibration, pulsar timing, confirmation of pulsar candidates, derivation of some further derived data products, archiving and providing the data to the users. It will accept visibilities at data rates at several TB/s and require processing power for imaging in range 100 petaFLOPS -- ~1 ExaFLOPS, putting SKA1 into the regime of exascale radio astronomy. In my talk I will present the overall SKA system requirements and how they drive these high data throughput and processing requirements. Some of the key challenges for the design of SDP are: - Identifying sufficient parallelism to utilise very large numbers of separate compute cores that will be required to provide exascale computing throughput - Managing efficiently the high internal data flow rates - A conceptual architecture and software engineering approach that will allow adaptation of the algorithms as we learn about the telescope and the atmosphere during the commissioning and operational phases - System management that will deal gracefully with (inevitably frequent) failures of individual units of the processing system In my talk I will present possible initial architectures for the SDP system that attempt to address these and other challenges.

VizieR Online Data Catalog: X-ATLAS X-ray sources photometric redshifts (Mountrichas+, 2017)

NASA Astrophysics Data System (ADS)

Mountrichas, G.; Corral, A.; Masoura, V. A.; Georgantopoulos, I.; Ruiz, A.; Georgakakis, A.; Carrera, F. J.; Fotopoulou, S.

2017-10-01

The Herschel Terahertz Large Area survey (H-ATLAS) is the largest Open Time Key Project carried out with the Herschel Space Observatory (Eales et al., 2010PASP..122..499E), covering an area of 550 deg2 in five far-infrared and sub-millimeter (submm) bands (100, 160, 250, 350, and 500um). 16 deg2 have been presented in the Science Demonstration Phase (SDP) catalogue (Rigby et al., 2011, Cat. J/MNRAS/415/2336) and lie within one of the regions observed by the Galaxy And Mass Assembly (GAMA) survey (Driver et al. 2011, Cat. J/MNRAS/413/971; Baldry et al. 2010MNRAS.404...86B). XMM-Newton observed 7.1 deg2 with a total exposure time of 336ks (in the MOS1 camera) within the H-ATLAS SDP area, making the XMM-ATLAS one of the largest contiguous areas of the sky with both XMM-Newton and Herschel coverage. The catalogue contains 1816 unique sources (Ranalli et al. 2015, Cat. J/A+A/577/A121). To obtain optical, mid-IR, and far-IR photometry for the XMM-ATLAS sources, we cross-matched the X-ray catalogue with the SDSS-DR13 (Albareti et al., 2015, Cat. J/MNRAS/452/4153), the WISE (Wright et al. 2010AJ....140.1868W, See Cat. II/311 and II/328), and the VISTA-VIKING catalogues (Emerson et al. 2006, Msngr, 126, 41; Dalton et al. 2006, SPIE, 6269, see Cat. II/343/) with the ARCHES cross-correlation tool xmatch, which symmetrically matches an arbitrary number of catalogues providing a Bayesian Probability of association or non-association (Pineau, 2016, eprint arXiv:1609.03457). (1 data file).

A Convex Formulation for Learning a Shared Predictive Structure from Multiple Tasks

PubMed Central

Chen, Jianhui; Tang, Lei; Liu, Jun; Ye, Jieping

2013-01-01

In this paper, we consider the problem of learning from multiple related tasks for improved generalization performance by extracting their shared structures. The alternating structure optimization (ASO) algorithm, which couples all tasks using a shared feature representation, has been successfully applied in various multitask learning problems. However, ASO is nonconvex and the alternating algorithm only finds a local solution. We first present an improved ASO formulation (iASO) for multitask learning based on a new regularizer. We then convert iASO, a nonconvex formulation, into a relaxed convex one (rASO). Interestingly, our theoretical analysis reveals that rASO finds a globally optimal solution to its nonconvex counterpart iASO under certain conditions. rASO can be equivalently reformulated as a semidefinite program (SDP), which is, however, not scalable to large datasets. We propose to employ the block coordinate descent (BCD) method and the accelerated projected gradient (APG) algorithm separately to find the globally optimal solution to rASO; we also develop efficient algorithms for solving the key subproblems involved in BCD and APG. The experiments on the Yahoo webpages datasets and the Drosophila gene expression pattern images datasets demonstrate the effectiveness and efficiency of the proposed algorithms and confirm our theoretical analysis. PMID:23520249

A New Cloud and Aerosol Layer Detection Method Based on Micropulse Lidar Measurements

NASA Astrophysics Data System (ADS)

Wang, Q.; Zhao, C.; Wang, Y.; Li, Z.; Wang, Z.; Liu, D.

2014-12-01

A new algorithm is developed to detect aerosols and clouds based on micropulse lidar (MPL) measurements. In this method, a semi-discretization processing (SDP) technique is first used to inhibit the impact of increasing noise with distance, then a value distribution equalization (VDE) method is introduced to reduce the magnitude of signal variations with distance. Combined with empirical threshold values, clouds and aerosols are detected and separated. This method can detect clouds and aerosols with high accuracy, although classification of aerosols and clouds is sensitive to the thresholds selected. Compared with the existing Atmospheric Radiation Measurement (ARM) program lidar-based cloud product, the new method detects more high clouds. The algorithm was applied to a year of observations at both the U.S. Southern Great Plains (SGP) and China Taihu site. At SGP, the cloud frequency shows a clear seasonal variation with maximum values in winter and spring, and shows bi-modal vertical distributions with maximum frequency at around 3-6 km and 8-12 km. The annual averaged cloud frequency is about 50%. By contrast, the cloud frequency at Taihu shows no clear seasonal variation and the maximum frequency is at around 1 km. The annual averaged cloud frequency is about 15% higher than that at SGP.

Maximum Margin Clustering of Hyperspectral Data

NASA Astrophysics Data System (ADS)

Niazmardi, S.; Safari, A.; Homayouni, S.

2013-09-01

In recent decades, large margin methods such as Support Vector Machines (SVMs) are supposed to be the state-of-the-art of supervised learning methods for classification of hyperspectral data. However, the results of these algorithms mainly depend on the quality and quantity of available training data. To tackle down the problems associated with the training data, the researcher put effort into extending the capability of large margin algorithms for unsupervised learning. One of the recent proposed algorithms is Maximum Margin Clustering (MMC). The MMC is an unsupervised SVMs algorithm that simultaneously estimates both the labels and the hyperplane parameters. Nevertheless, the optimization of the MMC algorithm is a non-convex problem. Most of the existing MMC methods rely on the reformulating and the relaxing of the non-convex optimization problem as semi-definite programs (SDP), which are computationally very expensive and only can handle small data sets. Moreover, most of these algorithms are two-class classification, which cannot be used for classification of remotely sensed data. In this paper, a new MMC algorithm is used that solve the original non-convex problem using Alternative Optimization method. This algorithm is also extended for multi-class classification and its performance is evaluated. The results of the proposed algorithm show that the algorithm has acceptable results for hyperspectral data clustering.

Metering Wheel-Wire Track Wire Boom Deployment Mechanism

NASA Technical Reports Server (NTRS)

Granoff, Mark S.

2014-01-01

The NASA MMS Spin Plane Double Probe (SDP) Deployer utilizes a helical path, rotating Metering Wheel and a spring loaded Wire "Holding" Track to pay out a "fixed end" 57 meter x 1.5 mm diameter Wire Boom stored between concentric storage cylinders. Unlike rotating spool type storage devices, the storage cylinders remain stationary, and the boom wire is uncoiled along the length of the cylinder via the rotation of the Metering Wheel. This uncoiling action avoids the need for slip-ring contacts since the ends of the wire can remain stationary. Conventional fixed electrical connectors (Micro-D type) are used to terminate to operational electronics.

Tachyon driven quantum cosmology in string theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garcia-Compean, H.; Garcia-Jimenez, G.; Obregon, O.

2005-03-15

Recently an effective action of the SDp-brane decaying process in string theory has been proposed. This effective description involves the Tachyon driven matter coupled to bosonic ten-dimensional Type II supergravity. Here the Hamiltonian formulation of this system is given. Exact solutions for the corresponding quantum theory by solving the Wheeler-deWitt equation in the late-time limit of the rolling tachyon are found. The energy spectrum and the probability densities for several values of p are shown and their possible interpretation is discussed. In the process the effects of electromagnetic fields are also incorporated and it is shown that in this casemore » the interpretation of tachyon regarded as 'matter clock' is modified.« less

Space Station Freedom (SSF) Data Management System (DMS) performance model data base

NASA Technical Reports Server (NTRS)

Stovall, John R.

1993-01-01

The purpose of this document was originally to be a working document summarizing Space Station Freedom (SSF) Data Management System (DMS) hardware and software design, configuration, performance and estimated loading data from a myriad of source documents such that the parameters provided could be used to build a dynamic performance model of the DMS. The document is published at this time as a close-out of the DMS performance modeling effort resulting from the Clinton Administration mandated Space Station Redesign. The DMS as documented in this report is no longer a part of the redesigned Space Station. The performance modeling effort was a joint undertaking between the National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) Flight Data Systems Division (FDSD) and the NASA Ames Research Center (ARC) Spacecraft Data Systems Research Branch. The scope of this document is limited to the DMS core network through the Man Tended Configuration (MTC) as it existed prior to the 1993 Clinton Administration mandated Space Station Redesign. Data is provided for the Standard Data Processors (SDP's), Multiplexer/Demultiplexers (MDM's) and Mass Storage Units (MSU's). Planned future releases would have added the additional hardware and software descriptions needed to describe the complete DMS. Performance and loading data through the Permanent Manned Configuration (PMC) was to have been included as it became available. No future releases of this document are presently planned pending completion of the present Space Station Redesign activities and task reassessment.

Multiantenna Relay Beamforming Design for QoS Discrimination in Two-Way Relay Networks

PubMed Central

Xiong, Ke; Zhang, Yu; Li, Dandan; Zhong, Zhangdui

2013-01-01

This paper investigates the relay beamforming design for quality of service (QoS) discrimination in two-way relay networks. The purpose is to keep legitimate two-way relay users exchange their information via a helping multiantenna relay with QoS guarantee while avoiding the exchanged information overhearing by unauthorized receiver. To this end, we propose a physical layer method, where the relay beamforming is jointly designed with artificial noise (AN) which is used to interfere in the unauthorized user's reception. We formulate the joint beamforming and AN (BFA) design into an optimization problem such that the received signal-to-interference-ratio (SINR) at the two legitimate users is over a predefined QoS threshold while limiting the received SINR at the unauthorized user which is under a certain secure threshold. The objective of the optimization problem is to seek the optimal AN and beamforming vectors to minimize the total power consumed by the relay node. Since the optimization problem is nonconvex, we solve it by using semidefinite program (SDP) relaxation. For comparison, we also study the optimal relay beamforming without using AN (BFO) under the same QoS discrimination constraints. Simulation results show that both the proposed BFA and BFO can achieve the QoS discrimination of the two-way transmission. However, the proposed BFA yields significant power savings and lower infeasible rates compared with the BFO method. PMID:24391459

The FIELDS Instrument Suite on MMS: Scientific Objectives, Measurements, and Data Products

NASA Astrophysics Data System (ADS)

Torbert, R. B.; Russell, C. T.; Magnes, W.; Ergun, R. E.; Lindqvist, P.-A.; Le Contel, O.; Vaith, H.; Macri, J.; Myers, S.; Rau, D.; Needell, J.; King, B.; Granoff, M.; Chutter, M.; Dors, I.; Olsson, G.; Khotyaintsev, Y. V.; Eriksson, A.; Kletzing, C. A.; Bounds, S.; Anderson, B.; Baumjohann, W.; Steller, M.; Bromund, K.; Le, Guan; Nakamura, R.; Strangeway, R. J.; Leinweber, H. K.; Tucker, S.; Westfall, J.; Fischer, D.; Plaschke, F.; Porter, J.; Lappalainen, K.

2016-03-01

The FIELDS instrumentation suite on the Magnetospheric Multiscale (MMS) mission provides comprehensive measurements of the full vector magnetic and electric fields in the reconnection regions investigated by MMS, including the dayside magnetopause and the night-side magnetotail acceleration regions out to 25 Re. Six sensors on each of the four MMS spacecraft provide overlapping measurements of these fields with sensitive cross-calibrations both before and after launch. The FIELDS magnetic sensors consist of redundant flux-gate magnetometers (AFG and DFG) over the frequency range from DC to 64 Hz, a search coil magnetometer (SCM) providing AC measurements over the full whistler mode spectrum expected to be seen on MMS, and an Electron Drift Instrument (EDI) that calibrates offsets for the magnetometers. The FIELDS three-axis electric field measurements are provided by two sets of biased double-probe sensors (SDP and ADP) operating in a highly symmetric spacecraft environment to reduce significantly electrostatic errors. These sensors are complemented with the EDI electric measurements that are free from all local spacecraft perturbations. Cross-calibrated vector electric field measurements are thus produced from DC to 100 kHz, well beyond the upper hybrid resonance whose frequency provides an accurate determination of the local electron density. Due to its very large geometric factor, EDI also provides very high time resolution (˜1 ms) ambient electron flux measurements at a few selected energies near 1 keV. This paper provides an overview of the FIELDS suite, its science objectives and measurement requirements, and its performance as verified in calibration and cross-calibration procedures that result in anticipated errors less than 0.1 nT in B and 0.5 mV/m in E. Summaries of data products that result from FIELDS are also described, as well as algorithms for cross-calibration. Details of the design and performance characteristics of AFG/DFG, SCM, ADP, SDP, and EDI are provided in five companion papers.

SDP_wlanger_3: State of the Diffuse ISM: Galactic Observations of the Terahertz CII Line (GOT CPlus)

NASA Astrophysics Data System (ADS)

Langer, W.

2011-09-01

Star formation activity throughout the Galactic disk depends on the thermal and dynamical state of the interstellar gas, which in turn depends on heating and cooling rates, modulated by the gravitational potential and shock and turbulent pressures. Molecular cloud formation, and thus the star formation, may be regulated by pressures in the interstellar medium (ISM). To understand these processes we need information about the properties of the diffuse atomic and diffuse molecular gas clouds, and Photon Dominated Regions (PDR). An important tracer of these regions is the CII line at 158 microns (1900.5 GHz). We propose a "pencil-beam" survey of CII with HIFI band 7b, based on deep integrations and systematic sparse sampling of the Galactic disk plus selected targets, totaling over 900 lines of sight. We will detect both emission and, against the bright inner Galaxy and selected continuum sources, absorption lines. These spectra will provide the astronomical community with a large rich statistical database of the diffuse cloud properties throughout the Galaxy for understanding the Milky Way ISM and, by extension, other galaxies. It will be extremely valuable for determining the properties of the atomic gas, the role of barometric pressure and turbulence in cloud evolution, and the properties of the interface between the atomic and molecular clouds. The CII line is one of the major ISM cooling lines and is present throughout the Galactic plane. It is the strongest far-IR emission line in the Galaxy, with a total luminosity about a 1000 times that of the CO J=1-0 line. Combined with other data, it can be used to determine density, pressure, and radiation environment in gas clouds, and PDRs, and their dynamics via velocity fields. HSO is the best opportunity over the next several years to probe the ISM in this tracer and will provide a template for large-scale surveys with dedicated small telescopes and future surveys of other important ISM tracers.

Overview of the DART project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berry, K.R.; Hansen, F.R.; Napolitano, L.M.

1992-01-01

DART (DSP Arrary for Reconfigurable Tasks) is a parallel architecture of two high-performance SDP (digital signal processing) chips with the flexibility to handle a wide range of real-time applications. Each of the 32-bit floating-point DSP processes in DART is programmable in a high-level languate ( C'' or Ada). We have added extensions to the real-time operating system used by DART in order to support parallel processor. The combination of high-level language programmability, a real-time operating system, and parallel processing support significantly reduces the development cost of application software for signal processing and control applications. We have demonstrated this capability bymore » using DART to reconstruct images in the prototype VIP (Video Imaging Projectile) groundstation.« less

Overview of the DART project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berry, K.R.; Hansen, F.R.; Napolitano, L.M.

1992-01-01

DART (DSP Arrary for Reconfigurable Tasks) is a parallel architecture of two high-performance SDP (digital signal processing) chips with the flexibility to handle a wide range of real-time applications. Each of the 32-bit floating-point DSP processes in DART is programmable in a high-level languate (``C`` or Ada). We have added extensions to the real-time operating system used by DART in order to support parallel processor. The combination of high-level language programmability, a real-time operating system, and parallel processing support significantly reduces the development cost of application software for signal processing and control applications. We have demonstrated this capability by usingmore » DART to reconstruct images in the prototype VIP (Video Imaging Projectile) groundstation.« less

Development of Condensing Mesh Method for Corner Domain at Numerical Simulation Magnetic System

NASA Astrophysics Data System (ADS)

Perepelkin, E.; Tarelkin, A.; Polyakova, R.; Kovalenko, A.

2018-05-01

A magnetostatic problem arises in searching for the distribution of the magnetic field generated by magnet systems of many physics research facilities, e.g., accelerators. The domain in which the boundaryvalue problem is solved often has a piecewise smooth boundary. In this case, numerical calculations of the problem require the consideration of the solution behavior in the corner domain. In this work we obtained the upper estimation of the magnetic field growth and propose a method of condensing the differential grid near the corner domain of vacuum in case of 3-dimensional space based on this estimation. An example of calculating a real model problem for SDP NICA in the domain containing a corner point is given.

Versatile and declarative dynamic programming using pair algebras.

PubMed

Steffen, Peter; Giegerich, Robert

2005-09-12

Dynamic programming is a widely used programming technique in bioinformatics. In sharp contrast to the simplicity of textbook examples, implementing a dynamic programming algorithm for a novel and non-trivial application is a tedious and error prone task. The algebraic dynamic programming approach seeks to alleviate this situation by clearly separating the dynamic programming recurrences and scoring schemes. Based on this programming style, we introduce a generic product operation of scoring schemes. This leads to a remarkable variety of applications, allowing us to achieve optimizations under multiple objective functions, alternative solutions and backtracing, holistic search space analysis, ambiguity checking, and more, without additional programming effort. We demonstrate the method on several applications for RNA secondary structure prediction. The product operation as introduced here adds a significant amount of flexibility to dynamic programming. It provides a versatile testbed for the development of new algorithmic ideas, which can immediately be put to practice.

Adaption of a corrector module to the IMP dynamics program

NASA Technical Reports Server (NTRS)

1972-01-01

The corrector module of the RAEIOS program and the IMP dynamics computer program were combined to achieve a date-fitting capability with the more general spacecraft dynamics models of the IMP program. The IMP dynamics program presents models of spacecraft dynamics for satellites with long, flexible booms. The properties of the corrector are discussed and a description is presented of the performance criteria and search logic for parameter estimation. A description is also given of the modifications made to add the corrector to the IMP program. This includes subroutine descriptions, common definitions, definition of input, and a description of output.

Large-scale hydropower system optimization using dynamic programming and object-oriented programming: the case of the Northeast China Power Grid.

PubMed

Li, Ji-Qing; Zhang, Yu-Shan; Ji, Chang-Ming; Wang, Ai-Jing; Lund, Jay R

2013-01-01

This paper examines long-term optimal operation using dynamic programming for a large hydropower system of 10 reservoirs in Northeast China. Besides considering flow and hydraulic head, the optimization explicitly includes time-varying electricity market prices to maximize benefit. Two techniques are used to reduce the 'curse of dimensionality' of dynamic programming with many reservoirs. Discrete differential dynamic programming (DDDP) reduces the search space and computer memory needed. Object-oriented programming (OOP) and the ability to dynamically allocate and release memory with the C++ language greatly reduces the cumulative effect of computer memory for solving multi-dimensional dynamic programming models. The case study shows that the model can reduce the 'curse of dimensionality' and achieve satisfactory results.

Effects of climate change on daily minimum and maximum temperatures and cloudiness in the Shikoku region: a statistical downscaling model approach

NASA Astrophysics Data System (ADS)

Tatsumi, Kenichi; Oizumi, Tsutao; Yamashiki, Yosuke

2015-04-01

In this study, we present a detailed analysis of the effect of changes in cloudiness (CLD) between a future period (2071-2099) and the base period (1961-1990) on daily minimum temperature (TMIN) and maximum temperature (TMAX) in the same period for the Shikoku region, Japan. This analysis was performed using climate data obtained with the use of the Statistical DownScaling Model (SDSM). We calibrated the SDSM using the National Center for Environmental Prediction (NCEP) reanalysis dataset for the SDSM input and daily time series of temperature and CLD from 10 surface data points (SDP) in Shikoku. Subsequently, we validated the SDSM outputs, specifically, TMIN, TMAX, and CLD, obtained with the use of the NCEP reanalysis dataset and general circulation model (GCM) data against the SDP. The GCM data used in the validation procedure were those from the Hadley Centre Coupled Model, version 3 (HadCM3) for the Special Report on Emission Scenarios (SRES) A2 and B2 scenarios and from the third generation Coupled Global Climate Model (CGCM3) for the SRES A2 and A1B scenarios. Finally, the validated SDSM was run to study the effect of future changes in CLD on TMIN and TMAX. Our analysis showed that (1) the negative linear fit between changes in TMAX and those in CLD was statistically significant in winter while the relationship between the two changes was not evident in summer, (2) the dependency of future changes in TMAX and TMIN on future changes in CLD were more evident in winter than in other seasons with the present SDSM, (3) the diurnal temperature range (DTR) decreased in the southern part of Shikoku in summer in all the SDSM projections while DTR increased in the northern part of Shikoku in the same season in these projections, (4) the dependencies of changes in DTR on changes in CLD were unclear in summer and winter. Results of the SDSM simulations performed for climate change scenarios such as those from this study contribute to local-scale agricultural and hydrological simulations and development of agricultural and hydrological models.

Idiopathic polyhydramnios: persistence across gestation and impact on pregnancy outcomes.

PubMed

Odibo, Imelda N; Newville, Trista M; Ounpraseuth, Songthip T; Dixon, Mandi; Lutgendorf, Monica A; Foglia, Lisa M; Magann, Everett F

2016-04-01

To investigate the likelihood of resolution of idiopathic polyhydramnios in pregnant women and compare outcomes between resolved and persistent cases. One hundred and sixty-three women with idiopathic polyhydramnios who delivered at two medical centers during a 3 year period (January 2012-January 2015) were included in the study. Exclusion criteria included congenital fetal anomalies, maternal diabetes, isoimmunization, fetal infection, placental tumors or anomalies, and multiple gestation. Polyhydramnios was defined as SDP≥8cm or AFI≥24cm. Resolved cases were defined as those with AFI and/or SDP falling and remaining below 24cm and 8cm respectively. Pregnancy outcomes were compared between resolved and persistent cases. Two-sample t-test or Wilcoxon rank-sum test was used for continuous variables while chi-square test or Fisher's exact test was used for categorical measures. Resolution was noted in 61 of 163 (37%) patients. There were no differences in maternal age, gravidity or parity between resolved and persistent cases. Mean gestational age at diagnosis of polyhydramnios and overall mean AFI were significantly lower in the cases that resolved (29.7±4.5 weeks vs 33.4±4.1 weeks, p<0.0001; 23.3±3.5cm vs 25.8 23.3±4.0cm, p=0.0002). Similar to AFI measurements, mean SDP was also lower in cases with resolution (p=0.002). There was no difference in induction rates, mode of delivery, amnioinfusion rates, meconium staining of amniotic fluid and fetal heart rate abnormalities influencing intrapartum management between the two groups. Induction of labor for fetal indication and rupture of membranes were significantly more common in the persistent group. Cesarean delivery for abnormal lie and fetal distress did not differ between the groups. There was an increased risk of macrosomia (>4000g) and preterm delivery (<37 weeks) in the persistent group (p<0.05). Resolution rate was approximately 37% and more likely in cases diagnosed earlier in pregnancy and with lower mean amniotic fluid volume. Preterm delivery and macrosomia were more common in cases that persisted across gestation. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

FINITE-STATE APPROXIMATIONS TO DENUMERABLE-STATE DYNAMIC PROGRAMS,

DTIC Science & Technology

AIR FORCE OPERATIONS, LOGISTICS), (*INVENTORY CONTROL, DYNAMIC PROGRAMMING), (*DYNAMIC PROGRAMMING, APPROXIMATION(MATHEMATICS)), INVENTORY CONTROL, DECISION MAKING, STOCHASTIC PROCESSES, GAME THEORY, ALGORITHMS, CONVERGENCE

A dynamic model of functioning of a bank

NASA Astrophysics Data System (ADS)

Malafeyev, Oleg; Awasthi, Achal; Zaitseva, Irina; Rezenkov, Denis; Bogdanova, Svetlana

2018-04-01

In this paper, we analyze dynamic programming as a novel approach to solve the problem of maximizing the profits of a bank. The mathematical model of the problem and the description of bank's work is described in this paper. The problem is then approached using the method of dynamic programming. Dynamic programming makes sure that the solutions obtained are globally optimal and numerically stable. The optimization process is set up as a discrete multi-stage decision process and solved with the help of dynamic programming.

Dynamic Optimization

NASA Technical Reports Server (NTRS)

Laird, Philip

1992-01-01

We distinguish static and dynamic optimization of programs: whereas static optimization modifies a program before runtime and is based only on its syntactical structure, dynamic optimization is based on the statistical properties of the input source and examples of program execution. Explanation-based generalization is a commonly used dynamic optimization method, but its effectiveness as a speedup-learning method is limited, in part because it fails to separate the learning process from the program transformation process. This paper describes a dynamic optimization technique called a learn-optimize cycle that first uses a learning element to uncover predictable patterns in the program execution and then uses an optimization algorithm to map these patterns into beneficial transformations. The technique has been used successfully for dynamic optimization of pure Prolog.

Addressing Dynamic Issues of Program Model Checking

NASA Technical Reports Server (NTRS)

Lerda, Flavio; Visser, Willem

2001-01-01

Model checking real programs has recently become an active research area. Programs however exhibit two characteristics that make model checking difficult: the complexity of their state and the dynamic nature of many programs. Here we address both these issues within the context of the Java PathFinder (JPF) model checker. Firstly, we will show how the state of a Java program can be encoded efficiently and how this encoding can be exploited to improve model checking. Next we show how to use symmetry reductions to alleviate some of the problems introduced by the dynamic nature of Java programs. Lastly, we show how distributed model checking of a dynamic program can be achieved, and furthermore, how dynamic partitions of the state space can improve model checking. We support all our findings with results from applying these techniques within the JPF model checker.

Analysis of structural dynamic data from Skylab. Volume 1: Technical discussion

NASA Technical Reports Server (NTRS)

Demchak, L.; Harcrow, H.

1976-01-01

A compendium of Skylab structural dynamics analytical and test programs is presented. These programs are assessed to identify lessons learned from the structural dynamic prediction effort and to provide guidelines for future analysts and program managers of complex spacecraft systems. It is a synopsis of the structural dynamic effort performed under the Skylab Integration contract and specifically covers the development, utilization, and correlation of Skylab Dynamic Orbital Models.

Joint Transmitter and Receiver Power Allocation under Minimax MSE Criterion with Perfect and Imperfect CSI for MC-CDMA Transmissions

NASA Astrophysics Data System (ADS)

Kotchasarn, Chirawat; Saengudomlert, Poompat

We investigate the problem of joint transmitter and receiver power allocation with the minimax mean square error (MSE) criterion for uplink transmissions in a multi-carrier code division multiple access (MC-CDMA) system. The objective of power allocation is to minimize the maximum MSE among all users each of which has limited transmit power. This problem is a nonlinear optimization problem. Using the Lagrange multiplier method, we derive the Karush-Kuhn-Tucker (KKT) conditions which are necessary for a power allocation to be optimal. Numerical results indicate that, compared to the minimum total MSE criterion, the minimax MSE criterion yields a higher total MSE but provides a fairer treatment across the users. The advantages of the minimax MSE criterion are more evident when we consider the bit error rate (BER) estimates. Numerical results show that the minimax MSE criterion yields a lower maximum BER and a lower average BER. We also observe that, with the minimax MSE criterion, some users do not transmit at full power. For comparison, with the minimum total MSE criterion, all users transmit at full power. In addition, we investigate robust joint transmitter and receiver power allocation where the channel state information (CSI) is not perfect. The CSI error is assumed to be unknown but bounded by a deterministic value. This problem is formulated as a semidefinite programming (SDP) problem with bilinear matrix inequality (BMI) constraints. Numerical results show that, with imperfect CSI, the minimax MSE criterion also outperforms the minimum total MSE criterion in terms of the maximum and average BERs.

Galactic Observations of Terahertz C+ (GOT C+): First Results: Inner Galaxy Survey

NASA Astrophysics Data System (ADS)

Langer, William; Velusamy, T.; Pineda, J. L.; Goldsmith, P. F.; Li, D.; Yorke, H. W.

2010-05-01

To understand the lifecycle of the interstellar gas and star formation we need detailed information about the diffuse atomic and diffuse molecular gas cloud properties. The ionized carbon [CII] 1.9 THz fine structure line is an important tracer of the atomic gas in the diffuse regions and the interface regions of atomic gas to molecular clouds. Furthermore, C+ is a major ISM coolant and among the Galaxy's strongest far-IR emission lines, and thus controls the thermal conditions throughout large parts of the Galaxy. Until now our knowledge of interstellar gas has been limited to the diffuse atomic phase traced by HI and to the dense molecular H2 phase traced by CO. However, we are missing an important phase of the ISM called "dark gas” in which there is no or little, HI, and mostly molecular hydrogen but with insufficient shielding of UV to allow CO to form. C+ emission and absorption lines at 1.9 THz have the potential to trace this gas. Galactic Observations of the Terahertz C+ Line (GOT C+) is a Herschel Space Observatory Open Time Key Program to study the diffuse interstellar medium by sampling [CII] 1.9 THz line emission throughout the Galactic disk. We discuss the broader perspective of this survey and the first results of GOT C+ obtained during the Science Demonstration Phase (SDP) and Priority Science Phase (PSP) of HIFI, which focus on approximately 100 lines of sight in the inner galaxy. This research was conducted at the Jet Propulsion Laboratory, California Institute of Technology under contract with the National Aeronautics and Space Administration.

Bellman's GAP--a language and compiler for dynamic programming in sequence analysis.

PubMed

Sauthoff, Georg; Möhl, Mathias; Janssen, Stefan; Giegerich, Robert

2013-03-01

Dynamic programming is ubiquitous in bioinformatics. Developing and implementing non-trivial dynamic programming algorithms is often error prone and tedious. Bellman's GAP is a new programming system, designed to ease the development of bioinformatics tools based on the dynamic programming technique. In Bellman's GAP, dynamic programming algorithms are described in a declarative style by tree grammars, evaluation algebras and products formed thereof. This bypasses the design of explicit dynamic programming recurrences and yields programs that are free of subscript errors, modular and easy to modify. The declarative modules are compiled into C++ code that is competitive to carefully hand-crafted implementations. This article introduces the Bellman's GAP system and its language, GAP-L. It then demonstrates the ease of development and the degree of re-use by creating variants of two common bioinformatics algorithms. Finally, it evaluates Bellman's GAP as an implementation platform of 'real-world' bioinformatics tools. Bellman's GAP is available under GPL license from http://bibiserv.cebitec.uni-bielefeld.de/bellmansgap. This Web site includes a repository of re-usable modules for RNA folding based on thermodynamics.

The Analysis of Soil Resistance During Screw Displacement Pile Installation

NASA Astrophysics Data System (ADS)

Krasinski, Adam

2015-02-01

The application of screw displacement piles (SDP) is still increasing due to their high efficiency and many advantages. However, one technological problem is a serious disadvantage of those piles. It relates to the generation of very high soil resistance during screw auger penetration, especially when piles are installed in non-cohesive soils. In many situations this problem causes difficulties in creating piles of designed length and diameter. It is necessary to find a proper method for prediction of soil resistance during screw pile installation. The analysis of screw resistances based on model and field tests is presented in the paper. The investigations were carried out as part of research project, financed by the Polish Ministry of Science and Higher Education. As a result of tests and analyses the empirical method for prediction of rotation resistance (torque) during screw auger penetration in non-cohesive subsoil based on CPT is proposed.

CrII Reactivity of Taurine/α-Ketoglutarate Dioxygenase

PubMed Central

Grzyska, Piotr K.; Hausinger, Robert P.

2008-01-01

The interaction of CrII with taurine/α-ketoglutarate (αKG) dioxygenase (TauD) was examined. CrII replaces FeII and binds stoichiometrically with αKG to the FeII/αKG-binding site of the protein, with additional CrII used to generate a chromophore attributed to a CrIII-semiquinone in a small percentage of the sample. Formation of the latter oxygen -sensitive species requires the dihydroxyphenylalanine (DOPA) quinone form of Tyr-73. This pre-formed side chain is generated by intracellular self-hydroxylation of Tyr-73 to form DOPA, which is subsequently oxidized to the quinone. No chromophore is generated when using NaBH4-treated sample, protein isolated from anaerobically grown cells, inactive TauD variants that are incapable of self-hydroxylation, or the Y73F active mutant of TauD. A CrIII-DOPA semiquinone also was observed in the herbicide hydroxylase SdpA. PMID:17973473

Cr(II) reactivity of taurine/alpha-ketoglutarate dioxygenase.

PubMed

Grzyska, Piotr K; Hausinger, Robert P

2007-11-26

The interaction of CrII with taurine/alpha-ketoglutarate (alphaKG) dioxygenase (TauD) was examined. CrII replaces FeII and binds stoichiometrically with alphaKG to the FeII/alphaKG binding site of the protein, with additional CrII used to generate a chromophore attributed to a CrIII-semiquinone in a small percentage of the sample. Formation of the latter oxygen-sensitive species requires the dihydroxyphenylalanine (DOPA) quinone form of Tyr-73. This preformed side chain is generated by intracellular self-hydroxylation of Tyr-73 to form DOPA, which is subsequently oxidized to the quinone. No chromophore is generated when using NaBH4-treated sample, protein isolated from anaerobically grown cells, inactive TauD variants that are incapable of self-hydroxylation, or the Y73F active mutant of TauD. A CrIII-DOPA semiquinone also was observed in the herbicide hydroxylase SdpA.

Spectral and physicochemical properties of difluoroboranyls containing N,N-dimethylamino group studied by solvatochromic methods

NASA Astrophysics Data System (ADS)

Jędrzejewska, Beata; Grabarz, Anna; Bartkowiak, Wojciech; Ośmiałowski, Borys

2018-06-01

The solvatochromism of the dyes was analyzed based on the four-parameter scale including: polarizability (SP), dipolarity (SdP), acidity (SA) and basicity (SB) parameters by method proposed by Catalán. The change of solvent to more polar caused the red shift of absorption and fluorescence band position. The frequency shifts manifest the change in the dipole moment upon excitation. The ground-state dipole moment of the difluoroboranyls was estimated based on changes in molecular polarization with temperature. Moreover, the Stokes shifts were used to calculate the excited state dipole moments of the dyes. For the calculation, the ground-state dipole moments and Onsager cavity radius were also determined theoretically using density functional theory (DFT). The experimentally determined excited-state dipole moments for the compounds are higher than the corresponding ground-state values. The increase in the dipole moment is described in terms of the nature of the excited state.

Ecological Research Division Theoretical Ecology Program. [Contains abstracts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1990-10-01

This report presents the goals of the Theoretical Ecology Program and abstracts of research in progress. Abstracts cover both theoretical research that began as part of the terrestrial ecology core program and new projects funded by the theoretical program begun in 1988. Projects have been clustered into four major categories: Ecosystem dynamics; landscape/scaling dynamics; population dynamics; and experiment/sample design.

INDDGO: Integrated Network Decomposition & Dynamic programming for Graph Optimization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Groer, Christopher S; Sullivan, Blair D; Weerapurage, Dinesh P

2012-10-01

It is well-known that dynamic programming algorithms can utilize tree decompositions to provide a way to solve some \\emph{NP}-hard problems on graphs where the complexity is polynomial in the number of nodes and edges in the graph, but exponential in the width of the underlying tree decomposition. However, there has been relatively little computational work done to determine the practical utility of such dynamic programming algorithms. We have developed software to construct tree decompositions using various heuristics and have created a fast, memory-efficient dynamic programming implementation for solving maximum weighted independent set. We describe our software and the algorithms wemore » have implemented, focusing on memory saving techniques for the dynamic programming. We compare the running time and memory usage of our implementation with other techniques for solving maximum weighted independent set, including a commercial integer programming solver and a semi-definite programming solver. Our results indicate that it is possible to solve some instances where the underlying decomposition has width much larger than suggested by the literature. For certain types of problems, our dynamic programming code runs several times faster than these other methods.« less

Computer program system for dynamic simulation and stability analysis of passive and actively controlled spacecraft. Volume 1. Theory

NASA Technical Reports Server (NTRS)

Bodley, C. S.; Devers, D. A.; Park, C. A.

1975-01-01

A theoretical development and associated digital computer program system is presented. The dynamic system (spacecraft) is modeled as an assembly of rigid and/or flexible bodies not necessarily in a topological tree configuration. The computer program system may be used to investigate total system dynamic characteristics including interaction effects between rigid and/or flexible bodies, control systems, and a wide range of environmental loadings. Additionally, the program system may be used for design of attitude control systems and for evaluation of total dynamic system performance including time domain response and frequency domain stability analyses. Volume 1 presents the theoretical developments including a description of the physical system, the equations of dynamic equilibrium, discussion of kinematics and system topology, a complete treatment of momentum wheel coupling, and a discussion of gravity gradient and environmental effects. Volume 2, is a program users' guide and includes a description of the overall digital program code, individual subroutines and a description of required program input and generated program output. Volume 3 presents the results of selected demonstration problems that illustrate all program system capabilities.

77 FR 19408 - Dynamic Mobility Applications and Data Capture Management Programs; Notice of Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-30

... DEPARTMENT OF TRANSPORTATION Dynamic Mobility Applications and Data Capture Management Programs...) Intelligent Transportation System Joint Program Office (ITS JPO) will host a free public meeting to provide stakeholders an update on the Data Capture and Management (DCM) and Dynamic Mobility Applications (DMA...

Multibody dynamics model building using graphical interfaces

NASA Technical Reports Server (NTRS)

Macala, Glenn A.

1989-01-01

In recent years, the extremely laborious task of manually deriving equations of motion for the simulation of multibody spacecraft dynamics has largely been eliminated. Instead, the dynamicist now works with commonly available general purpose dynamics simulation programs which generate the equations of motion either explicitly or implicitly via computer codes. The user interface to these programs has predominantly been via input data files, each with its own required format and peculiarities, causing errors and frustrations during program setup. Recent progress in a more natural method of data input for dynamics programs: the graphical interface, is described.

Earth and ocean dynamics program

NASA Technical Reports Server (NTRS)

Vonbun, F. O.

1976-01-01

The objectives and requirements of the Earth and Ocean Dynamics Programs are outlined along with major goals and experiments. Spaceborne as well as ground systems needed to accomplish program goals are listed and discussed along with program accomplishments.

Interaction with caveolin-1 modulates vascular ATP-sensitive potassium (KATP) channel activity

PubMed Central

Davies, Lowri M; Purves, Gregor I; Barrett-Jolley, Richard; Dart, Caroline

2010-01-01

ATP-sensitive potassium channels (KATP channels) of arterial smooth muscle are important regulators of arterial tone, and hence blood flow, in response to vasoactive transmitters. Recent biochemical and electron microscopic evidence suggests that these channels localise to small vesicular invaginations of the plasma membrane, known as caveolae, and interact with the caveolae-associated protein, caveolin. Here we report that interaction with caveolin functionally regulates the activity of the vascular subtype of KATP channel, Kir6.1/SUR2B. Pinacidil-evoked recombinant whole-cell Kir6.1/SUR2B currents recorded in HEK293 cells stably expressing caveolin-1 (69.6 ± 8.3 pA pF−1, n= 8) were found to be significantly smaller than currents recorded in caveolin-null cells (179.7 ± 35.9 pA pF−1, n= 6; P < 0.05) indicating that interaction with caveolin may inhibit channel activity. Inclusion in the pipette-filling solution of a peptide corresponding to the scaffolding domain of caveolin-1 had a similar inhibitory effect on whole-cell Kir6.1/SUR2B currents as co-expression with full-length caveolin-1, while a scrambled version of the same peptide had no effect. Interestingly, intracellular dialysis of vascular smooth muscle cells with the caveolin-1 scaffolding domain peptide (SDP) also caused inhibition of pinacidil-evoked native whole-cell KATP currents, indicating that a significant proportion of vascular KATP channels are susceptible to block by exogenously applied SDP. In cell-attached recordings of Kir6.1/SUR2B single channel activity, the presence of caveolin-1 significantly reduced channel open probability (from 0.05 ± 0.01 to 0.005 ± 0.001; P < 0.05) and the amount of time spent in a relatively long-lived open state. These changes in kinetic behaviour can be explained by a caveolin-induced shift in the channel's sensitivity to its physiological regulator MgADP. Our findings thus suggest that interaction with caveolin-1 suppresses vascular-type KATP channel activity. Since caveolin expression is regulated by cellular free cholesterol and plasma levels of low-density lipoprotein (LDL), this interaction may have implications in both the physiological and pathophysiological control of vascular function. PMID:20624795

Fluid dynamics computer programs for NERVA turbopump

NASA Technical Reports Server (NTRS)

Brunner, J. J.

1972-01-01

During the design of the NERVA turbopump, numerous computer programs were developed for the analyses of fluid dynamic problems within the machine. Program descriptions, example cases, users instructions, and listings for the majority of these programs are presented.

A digital computer program for the dynamic interaction simulation of controls and structure (DISCOS), volume 1

NASA Technical Reports Server (NTRS)

Bodley, C. S.; Devers, A. D.; Park, A. C.; Frisch, H. P.

1978-01-01

A theoretical development and associated digital computer program system for the dynamic simulation and stability analysis of passive and actively controlled spacecraft are presented. The dynamic system (spacecraft) is modeled as an assembly of rigid and/or flexible bodies not necessarily in a topological tree configuration. The computer program system is used to investigate total system dynamic characteristics, including interaction effects between rigid and/or flexible bodies, control systems, and a wide range of environmental loadings. In addition, the program system is used for designing attitude control systems and for evaluating total dynamic system performance, including time domain response and frequency domain stability analyses.

Program of Research in Structures and Dynamics

NASA Technical Reports Server (NTRS)

1988-01-01

The Structures and Dynamics Program was first initiated in 1972 with the following two major objectives: to provide a basic understanding and working knowledge of some key areas pertinent to structures, solid mechanics, and dynamics technology including computer aided design; and to provide a comprehensive educational and research program at the NASA Langley Research Center leading to advanced degrees in the structures and dynamics areas. During the operation of the program the research work was done in support of the activities of both the Structures and Dynamics Division and the Loads and Aeroelasticity Division. During the period of 1972 to 1986 the Program provided support for two full-time faculty members, one part-time faculty member, three postdoctoral fellows, one research engineer, eight programmers, and 28 graduate research assistants. The faculty and staff of the program have published 144 papers and reports, and made 70 presentations at national and international meetings, describing their research findings. In addition, they organized and helped in the organization of 10 workshops and national symposia in the structures and dynamics areas. The graduate research assistants and the students enrolled in the program have written 20 masters theses and 2 doctoral dissertations. The overall progress is summarized.

Bellman’s GAP—a language and compiler for dynamic programming in sequence analysis

PubMed Central

Sauthoff, Georg; Möhl, Mathias; Janssen, Stefan; Giegerich, Robert

2013-01-01

Motivation: Dynamic programming is ubiquitous in bioinformatics. Developing and implementing non-trivial dynamic programming algorithms is often error prone and tedious. Bellman’s GAP is a new programming system, designed to ease the development of bioinformatics tools based on the dynamic programming technique. Results: In Bellman’s GAP, dynamic programming algorithms are described in a declarative style by tree grammars, evaluation algebras and products formed thereof. This bypasses the design of explicit dynamic programming recurrences and yields programs that are free of subscript errors, modular and easy to modify. The declarative modules are compiled into C++ code that is competitive to carefully hand-crafted implementations. This article introduces the Bellman’s GAP system and its language, GAP-L. It then demonstrates the ease of development and the degree of re-use by creating variants of two common bioinformatics algorithms. Finally, it evaluates Bellman’s GAP as an implementation platform of ‘real-world’ bioinformatics tools. Availability: Bellman’s GAP is available under GPL license from http://bibiserv.cebitec.uni-bielefeld.de/bellmansgap. This Web site includes a repository of re-usable modules for RNA folding based on thermodynamics. Contact: robert@techfak.uni-bielefeld.de Supplementary information: Supplementary data are available at Bioinformatics online PMID:23355290

Use of a Computer Language in Teaching Dynamic Programming. Final Report.

ERIC Educational Resources Information Center

Trimble, C. J.; And Others

Most optimization problems of any degree of complexity must be solved using a computer. In the teaching of dynamic programing courses, it is often desirable to use a computer in problem solution. The solution process involves conceptual formulation and computational Solution. Generalized computer codes for dynamic programing problem solution…

The application of dynamic programming in production planning

NASA Astrophysics Data System (ADS)

Wu, Run

2017-05-01

Nowadays, with the popularity of the computers, various industries and fields are widely applying computer information technology, which brings about huge demand for a variety of application software. In order to develop software meeting various needs with most economical cost and best quality, programmers must design efficient algorithms. A superior algorithm can not only soul up one thing, but also maximize the benefits and generate the smallest overhead. As one of the common algorithms, dynamic programming algorithms are used to solving problems with some sort of optimal properties. When solving problems with a large amount of sub-problems that needs repetitive calculations, the ordinary sub-recursive method requires to consume exponential time, and dynamic programming algorithm can reduce the time complexity of the algorithm to the polynomial level, according to which we can conclude that dynamic programming algorithm is a very efficient compared to other algorithms reducing the computational complexity and enriching the computational results. In this paper, we expound the concept, basic elements, properties, core, solving steps and difficulties of the dynamic programming algorithm besides, establish the dynamic programming model of the production planning problem.

Approximating uncertainty of annual runoff and reservoir yield using stochastic replicates of global climate model data

NASA Astrophysics Data System (ADS)

Peel, M. C.; Srikanthan, R.; McMahon, T. A.; Karoly, D. J.

2015-04-01

Two key sources of uncertainty in projections of future runoff for climate change impact assessments are uncertainty between global climate models (GCMs) and within a GCM. Within-GCM uncertainty is the variability in GCM output that occurs when running a scenario multiple times but each run has slightly different, but equally plausible, initial conditions. The limited number of runs available for each GCM and scenario combination within the Coupled Model Intercomparison Project phase 3 (CMIP3) and phase 5 (CMIP5) data sets, limits the assessment of within-GCM uncertainty. In this second of two companion papers, the primary aim is to present a proof-of-concept approximation of within-GCM uncertainty for monthly precipitation and temperature projections and to assess the impact of within-GCM uncertainty on modelled runoff for climate change impact assessments. A secondary aim is to assess the impact of between-GCM uncertainty on modelled runoff. Here we approximate within-GCM uncertainty by developing non-stationary stochastic replicates of GCM monthly precipitation and temperature data. These replicates are input to an off-line hydrologic model to assess the impact of within-GCM uncertainty on projected annual runoff and reservoir yield. We adopt stochastic replicates of available GCM runs to approximate within-GCM uncertainty because large ensembles, hundreds of runs, for a given GCM and scenario are unavailable, other than the Climateprediction.net data set for the Hadley Centre GCM. To date within-GCM uncertainty has received little attention in the hydrologic climate change impact literature and this analysis provides an approximation of the uncertainty in projected runoff, and reservoir yield, due to within- and between-GCM uncertainty of precipitation and temperature projections. In the companion paper, McMahon et al. (2015) sought to reduce between-GCM uncertainty by removing poorly performing GCMs, resulting in a selection of five better performing GCMs from CMIP3 for use in this paper. Here we present within- and between-GCM uncertainty results in mean annual precipitation (MAP), mean annual temperature (MAT), mean annual runoff (MAR), the standard deviation of annual precipitation (SDP), standard deviation of runoff (SDR) and reservoir yield for five CMIP3 GCMs at 17 worldwide catchments. Based on 100 stochastic replicates of each GCM run at each catchment, within-GCM uncertainty was assessed in relative form as the standard deviation expressed as a percentage of the mean of the 100 replicate values of each variable. The average relative within-GCM uncertainties from the 17 catchments and 5 GCMs for 2015-2044 (A1B) were MAP 4.2%, SDP 14.2%, MAT 0.7%, MAR 10.1% and SDR 17.6%. The Gould-Dincer Gamma (G-DG) procedure was applied to each annual runoff time series for hypothetical reservoir capacities of 1 × MAR and 3 × MAR and the average uncertainties in reservoir yield due to within-GCM uncertainty from the 17 catchments and 5 GCMs were 25.1% (1 × MAR) and 11.9% (3 × MAR). Our approximation of within-GCM uncertainty is expected to be an underestimate due to not replicating the GCM trend. However, our results indicate that within-GCM uncertainty is important when interpreting climate change impact assessments. Approximately 95% of values of MAP, SDP, MAT, MAR, SDR and reservoir yield from 1 × MAR or 3 × MAR capacity reservoirs are expected to fall within twice their respective relative uncertainty (standard deviation/mean). Within-GCM uncertainty has significant implications for interpreting climate change impact assessments that report future changes within our range of uncertainty for a given variable - these projected changes may be due solely to within-GCM uncertainty. Since within-GCM variability is amplified from precipitation to runoff and then to reservoir yield, climate change impact assessments that do not take into account within-GCM uncertainty risk providing water resources management decision makers with a sense of certainty that is unjustified.

Representing and reasoning about program in situation calculus

NASA Astrophysics Data System (ADS)

Yang, Bo; Zhang, Ming-yi; Wu, Mao-nian; Xie, Gang

2011-12-01

Situation calculus is an expressive tool for modeling dynamical system in artificial intelligence, changes in a dynamical world is represented naturally by the notions of action, situation and fluent in situation calculus. Program can be viewed as a discrete dynamical system, so it is possible to model program with situation calculus. To model program written in a smaller core programming language CL, notion of fluent is expanded for representing value of expression. Together with some functions returning concerned objects from expressions, a basic action theory of CL programming is constructed. Under such a theory, some properties of program, such as correctness and termination can be reasoned about.

A Categorization of Dynamic Analyzers

NASA Technical Reports Server (NTRS)

Lujan, Michelle R.

1997-01-01

Program analysis techniques and tools are essential to the development process because of the support they provide in detecting errors and deficiencies at different phases of development. The types of information rendered through analysis includes the following: statistical measurements of code, type checks, dataflow analysis, consistency checks, test data,verification of code, and debugging information. Analyzers can be broken into two major categories: dynamic and static. Static analyzers examine programs with respect to syntax errors and structural properties., This includes gathering statistical information on program content, such as the number of lines of executable code, source lines. and cyclomatic complexity. In addition, static analyzers provide the ability to check for the consistency of programs with respect to variables. Dynamic analyzers in contrast are dependent on input and the execution of a program providing the ability to find errors that cannot be detected through the use of static analysis alone. Dynamic analysis provides information on the behavior of a program rather than on the syntax. Both types of analysis detect errors in a program, but dynamic analyzers accomplish this through run-time behavior. This paper focuses on the following broad classification of dynamic analyzers: 1) Metrics; 2) Models; and 3) Monitors. Metrics are those analyzers that provide measurement. The next category, models, captures those analyzers that present the state of the program to the user at specified points in time. The last category, monitors, checks specified code based on some criteria. The paper discusses each classification and the techniques that are included under them. In addition, the role of each technique in the software life cycle is discussed. Familiarization with the tools that measure, model and monitor programs provides a framework for understanding the program's dynamic behavior from different, perspectives through analysis of the input/output data.

Configuring Airspace Sectors with Approximate Dynamic Programming

NASA Technical Reports Server (NTRS)

Bloem, Michael; Gupta, Pramod

2010-01-01

In response to changing traffic and staffing conditions, supervisors dynamically configure airspace sectors by assigning them to control positions. A finite horizon airspace sector configuration problem models this supervisor decision. The problem is to select an airspace configuration at each time step while considering a workload cost, a reconfiguration cost, and a constraint on the number of control positions at each time step. Three algorithms for this problem are proposed and evaluated: a myopic heuristic, an exact dynamic programming algorithm, and a rollouts approximate dynamic programming algorithm. On problem instances from current operations with only dozens of possible configurations, an exact dynamic programming solution gives the optimal cost value. The rollouts algorithm achieves costs within 2% of optimal for these instances, on average. For larger problem instances that are representative of future operations and have thousands of possible configurations, excessive computation time prohibits the use of exact dynamic programming. On such problem instances, the rollouts algorithm reduces the cost achieved by the heuristic by more than 15% on average with an acceptable computation time.

Hydraulic dynamic analysis

NASA Technical Reports Server (NTRS)

Gale, R. L.; Nease, A. W.; Nelson, D. J.

1978-01-01

Computer program mathematically describes complete hydraulic systems to study their dynamic performance. Program employs subroutines that simulate components of hydraulic system, which are then controlled by main program. Program is useful to engineers working with detailed performance results of aircraft, spacecraft, or similar hydraulic systems.

User's guide to the western spruce budworm modeling system

Treesearch

Nicholas L. Crookston; J. J. Colbert; Paul W. Thomas; Katharine A. Sheehan; William P. Kemp

1990-01-01

The Budworm Modeling System is a set of four computer programs: The Budworm Dynamics Model, the Prognosis-Budworm Dynamics Model, the Prognosis-Budworm Damage Model, and the Parallel Processing-Budworm Dynamics Model. Input to the first three programs and the output produced are described in this guide. A guide to the fourth program will be published separately....

Optimal Least-Squares Unidimensional Scaling: Improved Branch-and-Bound Procedures and Comparison to Dynamic Programming

ERIC Educational Resources Information Center

Brusco, Michael J.; Stahl, Stephanie

2005-01-01

There are two well-known methods for obtaining a guaranteed globally optimal solution to the problem of least-squares unidimensional scaling of a symmetric dissimilarity matrix: (a) dynamic programming, and (b) branch-and-bound. Dynamic programming is generally more efficient than branch-and-bound, but the former is limited to matrices with…

Space station structures and dynamics test program

NASA Technical Reports Server (NTRS)

Moore, Carleton J.; Townsend, John S.; Ivey, Edward W.

1987-01-01

The design, construction, and operation of a low-Earth orbit space station poses unique challenges for development and implementation of new technology. The technology arises from the special requirement that the station be built and constructed to function in a weightless environment, where static loads are minimal and secondary to system dynamics and control problems. One specific challenge confronting NASA is the development of a dynamics test program for: (1) defining space station design requirements, and (2) identifying the characterizing phenomena affecting the station's design and development. A general definition of the space station dynamic test program, as proposed by MSFC, forms the subject of this report. The test proposal is a comprehensive structural dynamics program to be launched in support of the space station. The test program will help to define the key issues and/or problems inherent to large space structure analysis, design, and testing. Development of a parametric data base and verification of the math models and analytical analysis tools necessary for engineering support of the station's design, construction, and operation provide the impetus for the dynamics test program. The philosophy is to integrate dynamics into the design phase through extensive ground testing and analytical ground simulations of generic systems, prototype elements, and subassemblies. On-orbit testing of the station will also be used to define its capability.

A user's guide to the Flexible Spacecraft Dynamics and Control Program

NASA Technical Reports Server (NTRS)

Fedor, J. V.

1984-01-01

A guide to the use of the Flexible Spacecraft Dynamics Program (FSD) is presented covering input requirements, control words, orbit generation, spacecraft description and simulation options, and output definition. The program can be used in dynamics and control analysis as well as in orbit support of deployment and control of spacecraft. The program is applicable to inertially oriented spinning, Earth oriented or gravity gradient stabilized spacecraft. Internal and external environmental effects can be simulated.

User's guide for a computer program to analyze the LRC 16 ft transonic dynamics tunnel cable mount system

NASA Technical Reports Server (NTRS)

Barbero, P.; Chin, J.

1973-01-01

The theoretical derivation of the set of equations is discussed which is applicable to modeling the dynamic characteristics of aeroelastically-scaled models flown on the two-cable mount system in a 16 ft transonic dynamics tunnel. The computer program provided for the analysis is also described. The program calculates model trim conditions as well as 3 DOF longitudinal and lateral/directional dynamic conditions for various flying cable and snubber cable configurations. Sample input and output are included.

Frequency Domain Computer Programs for Prediction and Analysis of Rail Vehicle Dynamics : Volume 2. Appendixes

DOT National Transportation Integrated Search

1975-12-01

Frequency domain computer programs developed or acquired by TSC for the analysis of rail vehicle dynamics are described in two volumes. Volume 2 contains program listings including subroutines for the four TSC frequency domain programs described in V...

Genetic Diversity Analysis of Selected Capsicum annuum Genotypes based on Morpho-Physiological, Yield Characteristics and their Biochemical Properties.

PubMed

Ridzuan, Raihana; Yusop, Mohd Rafii; Mohammad Yusof, Martini; Ismail, Siti Izera; Miah, Gous; Magaji, Usman

2018-05-31

The assessment of the different desirable characters among the chili genotypes expanded the effective selection for crop improvement. Identification of genetically superior parents is important in assortment of the best parents to develop new chili hybrid. This study was done to assess the hereditary assorted variety of selected genotypes of Capsicum annuum based on their morpho-physiological and yield traits in two planting seasons. Further, their biochemical properties; capsaicinoids content (capsaicin and dihydrocapsaicin), add up to the content of phenolic and antioxidant action determination of unripe and ripe chili pepper fruits were carried out at dry fruits. AVPP9813 and Kulai 907 were observed to have high fruit yield with 541.39 g/plant and 502.64 g/plant, respectively. The most increased genotypic coefficient variation (GCV) and phenotypic coefficient of variation (PCV) were shown by the fruit number per plant (49.71% and 66.04%, respectively). High heritability was observed in yield characters viz-a-viz fruit weight, length and girth and indicated high genetic advance. Eight groups were obtained from the cluster analysis. For the biochemical analysis, the capsaicinoids content and total phenolic content were high in Chili Bangi 3 at unripe and ripe fruit stage while for antioxidant activity SDP203 was the highest in ripe dry fruit. Higher GCV and PCV combined with moderate to high heritability and high hereditary progress were seen in number of fruit per plant, fruit yield per plant and fruit weight per fruit. These findings are beneficial for chili pepper breeders to select desirable quantitative characters in C. annuum in their breeding program. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

A comparison of graph- and kernel-based -omics data integration algorithms for classifying complex traits.

PubMed

Yan, Kang K; Zhao, Hongyu; Pang, Herbert

2017-12-06

High-throughput sequencing data are widely collected and analyzed in the study of complex diseases in quest of improving human health. Well-studied algorithms mostly deal with single data source, and cannot fully utilize the potential of these multi-omics data sources. In order to provide a holistic understanding of human health and diseases, it is necessary to integrate multiple data sources. Several algorithms have been proposed so far, however, a comprehensive comparison of data integration algorithms for classification of binary traits is currently lacking. In this paper, we focus on two common classes of integration algorithms, graph-based that depict relationships with subjects denoted by nodes and relationships denoted by edges, and kernel-based that can generate a classifier in feature space. Our paper provides a comprehensive comparison of their performance in terms of various measurements of classification accuracy and computation time. Seven different integration algorithms, including graph-based semi-supervised learning, graph sharpening integration, composite association network, Bayesian network, semi-definite programming-support vector machine (SDP-SVM), relevance vector machine (RVM) and Ada-boost relevance vector machine are compared and evaluated with hypertension and two cancer data sets in our study. In general, kernel-based algorithms create more complex models and require longer computation time, but they tend to perform better than graph-based algorithms. The performance of graph-based algorithms has the advantage of being faster computationally. The empirical results demonstrate that composite association network, relevance vector machine, and Ada-boost RVM are the better performers. We provide recommendations on how to choose an appropriate algorithm for integrating data from multiple sources.

Galactic Observations of Terahertz C+ (GOT C+): Inner Galaxy Survey

NASA Astrophysics Data System (ADS)

Yorke, Harold; Langer, William; Velusamy, T.; Pineda, J. L.; Goldsmith, P. F.; Li, D.

To understand the lifecycle of the interstellar gas and star formation we need detailed information about the diffuse atomic and diffuse molecular gas cloud properties. The ionized carbon [CII] 1.9 THz fine structure line is an important tracer of the atomic gas in the diffuse regions and the interface regions of atomic gas to molecular clouds. Furthermore, C+ is a major ISM coolant and among the Galaxy's strongest far-IR emission lines, and thus controls the thermal conditions throughout large parts of the Galaxy. Until now our knowledge of interstellar gas has been limited to the diffuse atomic phase traced by HI and to the dense molecular H2 phase traced by CO. However, we are missing an important phase of the ISM, called "dark gas" in which there is no or little, HI, and mostly molecular hydrogen but with insufficient shielding of UV to allow CO to form. C+ emission and absorption lines at 1.9 THz have the potential to trace such cloud transitions and evolution. Galactic Observations of the Terahertz C+ Line (GOT C+) is a Herschel Space Observatory Open Time Key Program to study the diffuse interstellar medium by sampling [CII] 1.9 THz line emission throughout the Galactic disk. We discuss the broader perspective of this survey and the first results of GOT C+ obtained during the Science Demonstration Phase (SDP) and Priority Science Phase (PSP) of HIFI, which focus on approximately 100 lines of sight in the inner galaxy. These observations are being carried out with the Herschel Space Observatory, which is an ESA cornerstone mission, with contributions from NASA. This research was conducted at the Jet Propulsion Laboratory, California Institute of Technology under contract with the National Aeronautics and Space Administration. JLP is a Caltech-JPL Postdoctoral Associate.

Integrated Network Decompositions and Dynamic Programming for Graph Optimization (INDDGO)

DOE Office of Scientific and Technical Information (OSTI.GOV)

The INDDGO software package offers a set of tools for finding exact solutions to graph optimization problems via tree decompositions and dynamic programming algorithms. Currently the framework offers serial and parallel (distributed memory) algorithms for finding tree decompositions and solving the maximum weighted independent set problem. The parallel dynamic programming algorithm is implemented on top of the MADNESS task-based runtime.

Hamilton-Jacobi-Bellman equations and approximate dynamic programming on time scales.

PubMed

Seiffertt, John; Sanyal, Suman; Wunsch, Donald C

2008-08-01

The time scales calculus is a key emerging area of mathematics due to its potential use in a wide variety of multidisciplinary applications. We extend this calculus to approximate dynamic programming (ADP). The core backward induction algorithm of dynamic programming is extended from its traditional discrete case to all isolated time scales. Hamilton-Jacobi-Bellman equations, the solution of which is the fundamental problem in the field of dynamic programming, are motivated and proven on time scales. By drawing together the calculus of time scales and the applied area of stochastic control via ADP, we have connected two major fields of research.

A Simulation Program for Dynamic Infrared (IR) Spectra

ERIC Educational Resources Information Center

Zoerb, Matthew C.; Harris, Charles B.

2013-01-01

A free program for the simulation of dynamic infrared (IR) spectra is presented. The program simulates the spectrum of two exchanging IR peaks based on simple input parameters. Larger systems can be simulated with minor modifications. The program is available as an executable program for PCs or can be run in MATLAB on any operating system. Source…

The Dynamics of Language Program Direction. Issues in Language Program Direction: A Series of Annual Volumes.

ERIC Educational Resources Information Center

Benseler, David P., Ed.

This collection papers begins with "Introduction: The Dynamics of Successful Leadership in Foreign Language Programs," then features the following: "The Undergraduate Program: Autonomy and Empowerment" (Wilga M. Rivers); "TA Supervision: Are We Preparing a Future Professoriate?" (Cathy Pons); "Applied Scholarship…

A short note on dynamic programming in a band.

PubMed

Gibrat, Jean-François

2018-06-15

Third generation sequencing technologies generate long reads that exhibit high error rates, in particular for insertions and deletions which are usually the most difficult errors to cope with. The only exact algorithm capable of aligning sequences with insertions and deletions is a dynamic programming algorithm. In this note, for the sake of efficiency, we consider dynamic programming in a band. We show how to choose the band width in function of the long reads' error rates, thus obtaining an [Formula: see text] algorithm in space and time. We also propose a procedure to decide whether this algorithm, when applied to semi-global alignments, provides the optimal score. We suggest that dynamic programming in a band is well suited to the problem of aligning long reads between themselves and can be used as a core component of methods for obtaining a consensus sequence from the long reads alone. The function implementing the dynamic programming algorithm in a band is available, as a standalone program, at: https://forgemia.inra.fr/jean-francois.gibrat/BAND_DYN_PROG.git.

An energy management for series hybrid electric vehicle using improved dynamic programming

NASA Astrophysics Data System (ADS)

Peng, Hao; Yang, Yaoquan; Liu, Chunyu

2018-02-01

With the increasing numbers of hybrid electric vehicle (HEV), management for two energy sources, engine and battery, is more and more important to achieve the minimum fuel consumption. This paper introduces several working modes of series hybrid electric vehicle (SHEV) firstly and then describes the mathematical model of main relative components in SHEV. On the foundation of this model, dynamic programming is applied to distribute energy of engine and battery on the platform of matlab and acquires less fuel consumption compared with traditional control strategy. Besides, control rule recovering energy in brake profiles is added into dynamic programming, so shorter computing time is realized by improved dynamic programming and optimization on algorithm.

Easy GROMACS: A Graphical User Interface for GROMACS Molecular Dynamics Simulation Package

NASA Astrophysics Data System (ADS)

Dizkirici, Ayten; Tekpinar, Mustafa

2015-03-01

GROMACS is a widely used molecular dynamics simulation package. Since it is a command driven program, it is difficult to use this program for molecular biologists, biochemists, new graduate students and undergraduate researchers who are interested in molecular dynamics simulations. To alleviate the problem for those researchers, we wrote a graphical user interface that simplifies protein preparation for a classical molecular dynamics simulation. Our program can work with various GROMACS versions and it can perform essential analyses of GROMACS trajectories as well as protein preparation. We named our open source program `Easy GROMACS'. Easy GROMACS can give researchers more time for scientific research instead of dealing with technical intricacies.

Investigation of Dynamic and Physical Processes in the Upper Troposphere and Lower Stratosphere

NASA Technical Reports Server (NTRS)

Selkirk, Henry B.; Pfister, Leonhard (Technical Monitor)

2002-01-01

Research under this Cooperative Agreement has been funded by several NASA Earth Science programs: the Atmospheric Effects of Radiation Program (AEAP), the Upper Atmospheric Research Program (UARP), and most recently the Atmospheric Chemistry and Modeling Assessment Program (ACMAP). The purpose of the AEAP was to understand the impact of the present and future fleets of conventional jet traffic on the upper troposphere and lower stratosphere, while complementary airborne observations under UARP seek to understand the complex interactions of dynamical and chemical processes that affect the ozone layer. The ACMAP is a more general program of modeling and data analysis in the general area of atmospheric chemistry and dynamics, and the Radiation Sciences program.

Hybrid Differential Dynamic Programming with Stochastic Search

NASA Technical Reports Server (NTRS)

Aziz, Jonathan; Parker, Jeffrey; Englander, Jacob

2016-01-01

Differential dynamic programming (DDP) has been demonstrated as a viable approach to low-thrust trajectory optimization, namely with the recent success of NASAs Dawn mission. The Dawn trajectory was designed with the DDP-based Static Dynamic Optimal Control algorithm used in the Mystic software. Another recently developed method, Hybrid Differential Dynamic Programming (HDDP) is a variant of the standard DDP formulation that leverages both first-order and second-order state transition matrices in addition to nonlinear programming (NLP) techniques. Areas of improvement over standard DDP include constraint handling, convergence properties, continuous dynamics, and multi-phase capability. DDP is a gradient based method and will converge to a solution nearby an initial guess. In this study, monotonic basin hopping (MBH) is employed as a stochastic search method to overcome this limitation, by augmenting the HDDP algorithm for a wider search of the solution space.

Separation of left and right lungs using 3D information of sequential CT images and a guided dynamic programming algorithm

PubMed Central

Park, Sang Cheol; Leader, Joseph Ken; Tan, Jun; Lee, Guee Sang; Kim, Soo Hyung; Na, In Seop; Zheng, Bin

2011-01-01

Objective this article presents a new computerized scheme that aims to accurately and robustly separate left and right lungs on CT examinations. Methods we developed and tested a method to separate the left and right lungs using sequential CT information and a guided dynamic programming algorithm using adaptively and automatically selected start point and end point with especially severe and multiple connections. Results the scheme successfully identified and separated all 827 connections on the total 4034 CT images in an independent testing dataset of CT examinations. The proposed scheme separated multiple connections regardless of their locations, and the guided dynamic programming algorithm reduced the computation time to approximately 4.6% in comparison with the traditional dynamic programming and avoided the permeation of the separation boundary into normal lung tissue. Conclusions The proposed method is able to robustly and accurately disconnect all connections between left and right lungs and the guided dynamic programming algorithm is able to remove redundant processing. PMID:21412104

Separation of left and right lungs using 3-dimensional information of sequential computed tomography images and a guided dynamic programming algorithm.

PubMed

Park, Sang Cheol; Leader, Joseph Ken; Tan, Jun; Lee, Guee Sang; Kim, Soo Hyung; Na, In Seop; Zheng, Bin

2011-01-01

This article presents a new computerized scheme that aims to accurately and robustly separate left and right lungs on computed tomography (CT) examinations. We developed and tested a method to separate the left and right lungs using sequential CT information and a guided dynamic programming algorithm using adaptively and automatically selected start point and end point with especially severe and multiple connections. The scheme successfully identified and separated all 827 connections on the total 4034 CT images in an independent testing data set of CT examinations. The proposed scheme separated multiple connections regardless of their locations, and the guided dynamic programming algorithm reduced the computation time to approximately 4.6% in comparison with the traditional dynamic programming and avoided the permeation of the separation boundary into normal lung tissue. The proposed method is able to robustly and accurately disconnect all connections between left and right lungs, and the guided dynamic programming algorithm is able to remove redundant processing.

Terrain Mechanics and Modeling Research Program: Enhanced Vehicle Dynamics Module

DTIC Science & Technology

2009-05-01

ER D C/ G SL T R- 09 -8 Terrain Mechanics and Modeling Research Program Enhanced Vehicle Dynamics Module Daniel C. Creighton, George...public release; distribution is unlimited. Terrain Mechanics and Modeling Research Program ERDC/GSL TR-09-8 May 2009 Enhanced Vehicle Dynamics...Module Daniel C. Creighton, George B. McKinley, and Randolph A. Jones Geotechnical and Structures Laboratory U.S. Army Engineer Research and

Thermosphere-ionosphere-mesosphere energetics and dynamics (TIMED). The TIMED mission and science program report of the science definition team. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1991-01-01

A Science Definition Team was established in December 1990 by the Space Physics Division, NASA, to develop a satellite program to conduct research on the energetics, dynamics, and chemistry of the mesosphere and lower thermosphere/ionosphere. This two-volume publication describes the TIMED (Thermosphere-Ionosphere-Mesosphere, Energetics and Dynamics) mission and associated science program. The report outlines the scientific objectives of the mission, the program requirements, and the approach towards meeting these requirements.

Dynamic mobility applications open source application development portal : Task 3.3 : concept of operations : final report.

DOT National Transportation Integrated Search

2016-10-12

The Dynamic Mobility Applications (DMA) program seeks to promote the highest level of collaboration and preservation of intellectual capital generated from application development and associated research activities funded by the program. The program ...

Technology development program for an advanced microsheet glass concentrator

NASA Technical Reports Server (NTRS)

Richter, Scott W.; Lacy, Dovie E.

1990-01-01

Solar Dynamic Space Power Systems are candidate electrical power generating systems for future NASA missions. One of the key components in a solar dynamic power system is the concentrator which collects the sun's energy and focuses it into a receiver. In 1985, the NASA Lewis Research Center initiated the Advanced Solar Dynamic Concentrator Program with funding from NASA's Office of Aeronautics and Space Technology (OAST). The objectives of the Advanced Concentrator Program is to develop the technology that will lead to lightweight, highly reflective, accurate, scaleable, and long lived (7 to 10 years) space solar dynamic concentrators. The Advanced Concentrator Program encompasses new and innovative concepts, fabrication techniques, materials selection, and simulated space environmental testing. The Advanced Microsheet Glass Concentrator Program, a reflector concept, that is currently being investigated both in-house and under contract is discussed.

Correlation between porosity and space holder content at different sintering temperatures of aluminum foam

NASA Astrophysics Data System (ADS)

Rushdi, N. M. F. M.; Jamaludin, S. B.; Mazlee, M. N.; Jamal, Z. A. Z.

2016-07-01

Aluminum foam is the most popular metal foam that can be used as energy absorbers, heat exchangers, air-oil separators and structure core of fuel cells. Melt-foaming agent, melt-gas injection, investment casting and powder-foaming agent techniques can be used to manufacture aluminum foam, but these techniques are too expensive. In this study, the aluminum foam was manufactured via a sintering dissolution process (SDP). Powders of aluminum and sodium chloride as space holder (25, 40, 50 wt. %) were mixed together to produce a homogeneous mixture. The mixture was compacted at 200 MPa followed by sintering at 500, 550 and 600˚C for 2 hours. A warm running water stream was used to dissolve the space holder that was embedded in the aluminum. The result showed that, the space holder content performed a significant role to control the total porosity to a value between 18 and 40%, and the porosity increased with increasing content of space holder and sintering temperature.

Quickbird Geometry Report for Summer 2003

NASA Technical Reports Server (NTRS)

Darbha, Ravikanth; Helder, Dennis; Choi, Taeyoung

2005-01-01

Digital Globe provides for general use 2.4 m multi-spectral and 0.7 m panchromatic imagery acquired by the Quickbird satellite. This geometrically corrected imagery was obtained as standard and orthorectified products; the difference between the two products is primarily in the degree of geometric accuracy that Digital Globe claims. For both products, every image pixel contains estimated sets of Northing/Easting and lat/long coordinates accessible through an image display application such as ENVI. Ground processing was performed by Digital Globe using the ADP 2.1 version of their system. Analysis conducted at South Dakota State University attempted to verify the geometric accuracy of standard and orthorectified Quickbird imagery to determine if specifications for the NASA Science Data Purchase (SDP) were met. These specifications are in Table 1 of Appendix 1. In this analysis, we had approximately 90 Ground Control Points (varies depending on scene size on each date), uniformly distributed over the Brookings, SD, area, from 4 Quickbird scenes acquired August 23, September 15, and October 21 of 2003.

The Improvement of Utilization Ratio of Metal Organic Sources for the Low Cost Preparation of MOCVD-synthesized YBCO Films based on a Self-heating Technology

NASA Astrophysics Data System (ADS)

Zhao, Ruipeng; Liu, Qing; Xia, Yudong; Tao, Bowan; Li, Yanrong

2017-12-01

We have successfully applied metal organic chemical vapor deposition (MOCVD) to synthesize biaxially textured YBa2Cu3O7-δ (YBCO) superconducting films on the templates of LaMnO3/epitaxial MgO/IBAD-MgO/solution deposition planarization (SDP) Y2O3/Hastelloy tape. The YBCO films have obtained dense and smooth surface with good structure and performance. A new self-heating method, which replaced the conventional heating-wire radiation heating method, has been used to heat the Hastelloy metal tapes by us. Compared with the heating-wire radiation heating method, the self-heating method shows higher energy efficiency and lower power consumption, which has good advantage to simplify the structure of the MOCVD system. Meanwhile, the utilization ratio of metal organic sources can be increased from 6% to 20% through adopting the new self-heating method. Then the preparation cost of the YBCO films can be also greatly reduced.

Introduction to the Application of the Dynalist Computer Program to the Analysis of Rail Systems Dynamics

DOT National Transportation Integrated Search

1974-08-01

DYNALIST, a computer program that extracts complex eigenvalues and eigenvectors for dynamic systems described in terms of matrix equations of motion, has been acquired and made operational at TSC. In this report, simple dynamic systems are used to de...

Hybrid Differential Dynamic Programming with Stochastic Search

NASA Technical Reports Server (NTRS)

Aziz, Jonathan; Parker, Jeffrey; Englander, Jacob A.

2016-01-01

Differential dynamic programming (DDP) has been demonstrated as a viable approach to low-thrust trajectory optimization, namely with the recent success of NASA's Dawn mission. The Dawn trajectory was designed with the DDP-based Static/Dynamic Optimal Control algorithm used in the Mystic software.1 Another recently developed method, Hybrid Differential Dynamic Programming (HDDP),2, 3 is a variant of the standard DDP formulation that leverages both first-order and second-order state transition matrices in addition to nonlinear programming (NLP) techniques. Areas of improvement over standard DDP include constraint handling, convergence properties, continuous dynamics, and multi-phase capability. DDP is a gradient based method and will converge to a solution nearby an initial guess. In this study, monotonic basin hopping (MBH) is employed as a stochastic search method to overcome this limitation, by augmenting the HDDP algorithm for a wider search of the solution space.

Frequency Domain Computer Programs for Prediction and Analysis of Rail Vehicle Dynamics : Volume 1. Technical Report

DOT National Transportation Integrated Search

1975-12-01

Frequency domain computer programs developed or acquired by TSC for the analysis of rail vehicle dynamics are described in two volumes. Volume I defines the general analytical capabilities required for computer programs applicable to single rail vehi...

Capacity planning for waste management systems: an interval fuzzy robust dynamic programming approach.

PubMed

Nie, Xianghui; Huang, Guo H; Li, Yongping

2009-11-01

This study integrates the concepts of interval numbers and fuzzy sets into optimization analysis by dynamic programming as a means of accounting for system uncertainty. The developed interval fuzzy robust dynamic programming (IFRDP) model improves upon previous interval dynamic programming methods. It allows highly uncertain information to be effectively communicated into the optimization process through introducing the concept of fuzzy boundary interval and providing an interval-parameter fuzzy robust programming method for an embedded linear programming problem. Consequently, robustness of the optimization process and solution can be enhanced. The modeling approach is applied to a hypothetical problem for the planning of waste-flow allocation and treatment/disposal facility expansion within a municipal solid waste (MSW) management system. Interval solutions for capacity expansion of waste management facilities and relevant waste-flow allocation are generated and interpreted to provide useful decision alternatives. The results indicate that robust and useful solutions can be obtained, and the proposed IFRDP approach is applicable to practical problems that are associated with highly complex and uncertain information.

Dynamic Programming: An Introduction by Example

ERIC Educational Resources Information Center

Zietz, Joachim

2007-01-01

The author introduces some basic dynamic programming techniques, using examples, with the help of the computer algebra system "Maple". The emphasis is on building confidence and intuition for the solution of dynamic problems in economics. To integrate the material better, the same examples are used to introduce different techniques. One covers the…

DAVE-ML Utility Programs

NASA Technical Reports Server (NTRS)

Jackson, Bruce

2006-01-01

DAVEtools is a set of Java archives that embodies tools for manipulating flight-dynamics models that have been encoded in dynamic aerospace vehicle exchange markup language (DAVE-ML). [DAVE-ML is an application program, written in Extensible Markup Language (XML), for encoding complete computational models of the dynamics of aircraft and spacecraft.

MSC products for the simulation of tire behavior

NASA Technical Reports Server (NTRS)

Muskivitch, John C.

1995-01-01

The modeling of tires and the simulation of tire behavior are complex problems. The MacNeal-Schwendler Corporation (MSC) has a number of finite element analysis products that can be used to address the complexities of tire modeling and simulation. While there are many similarities between the products, each product has a number of capabilities that uniquely enable it to be used for a specific aspect of tire behavior. This paper discusses the following programs: (1) MSC/NASTRAN - general purpose finite element program for linear and nonlinear static and dynamic analysis; (2) MSC/ADAQUS - nonlinear statics and dynamics finite element program; (3) MSC/PATRAN AFEA (Advanced Finite Element Analysis) - general purpose finite element program with a subset of linear and nonlinear static and dynamic analysis capabilities with an integrated version of MSC/PATRAN for pre- and post-processing; and (4) MSC/DYTRAN - nonlinear explicit transient dynamics finite element program.

Model-based control strategies for systems with constraints of the program type

NASA Astrophysics Data System (ADS)

Jarzębowska, Elżbieta

2006-08-01

The paper presents a model-based tracking control strategy for constrained mechanical systems. Constraints we consider can be material and non-material ones referred to as program constraints. The program constraint equations represent tasks put upon system motions and they can be differential equations of orders higher than one or two, and be non-integrable. The tracking control strategy relies upon two dynamic models: a reference model, which is a dynamic model of a system with arbitrary order differential constraints and a dynamic control model. The reference model serves as a motion planner, which generates inputs to the dynamic control model. It is based upon a generalized program motion equations (GPME) method. The method enables to combine material and program constraints and merge them both into the motion equations. Lagrange's equations with multipliers are the peculiar case of the GPME, since they can be applied to systems with constraints of first orders. Our tracking strategy referred to as a model reference program motion tracking control strategy enables tracking of any program motion predefined by the program constraints. It extends the "trajectory tracking" to the "program motion tracking". We also demonstrate that our tracking strategy can be extended to a hybrid program motion/force tracking.

Exploration of government policy structure which support and block energy transition process in indonesia using system dynamics model

NASA Astrophysics Data System (ADS)

Destyanto, A. R.; Silalahi, T. D.; Hidayatno, A.

2017-11-01

System dynamic modeling is widely used to predict and simulate the energy system in several countries. One of the applications of system dynamics is to evaluate national energy policy alternatives, and energy efficiency analysis. Using system dynamic modeling, this research aims to evaluate the energy transition policy that has been implemented in Indonesia on the past conversion program of kerosene to LPG for household cook fuel consumption, which considered as successful energy transition program implemented since 2007. This research is important since Indonesia considered not yet succeeded to execute another energy transition program on conversion program of oil fuel to gas fuel for transportation that has started since 1989. The aim of this research is to explore which policy intervention that has significant contribution to support or even block the conversion program. Findings in this simulation show that policy intervention to withdraw the kerosene supply and government push to increase production capacity of the support equipment industries (gas stove, regulator, and LPG Cylinder) is the main influence on the success of the program conversion program.

Geodynamics Branch research report, 1982

NASA Technical Reports Server (NTRS)

Kahn, W. D. (Editor); Cohen, S. C. (Editor)

1983-01-01

The research program of the Geodynamics Branch is summarized. The research activities cover a broad spectrum of geoscience disciplines including space geodesy, geopotential field modeling, tectonophysics, and dynamic oceanography. The NASA programs which are supported by the work described include the Geodynamics and Ocean Programs, the Crustal Dynamics Project, the proposed Ocean Topography Experiment (TOPEX) and Geopotential Research Mission. The individual papers are grouped into chapters on Crustal Movements, Global Earth Dynamics, Gravity Field Model Development, Sea Surface Topography, and Advanced Studies.

A Government/Industry Summary of the Design Analysis Methods for Vibrations (DAMVIBS) Program

NASA Technical Reports Server (NTRS)

Kvaternik, Raymond G. (Compiler)

1993-01-01

The NASA Langley Research Center in 1984 initiated a rotorcraft structural dynamics program, designated DAMVIBS (Design Analysis Methods for VIBrationS), with the objective of establishing the technology base needed by the rotorcraft industry for developing an advanced finite-element-based dynamics design analysis capability for vibrations. An assessment of the program showed that the DAMVIBS Program has resulted in notable technical achievements and major changes in industrial design practice, all of which have significantly advanced the industry's capability to use and rely on finite-element-based dynamics analyses during the design process.

Decision Support Model for Municipal Solid Waste Management at Department of Defense Installations.

DTIC Science & Technology

1995-12-01

Huang uses "Grey Dynamic Programming for Waste Management Planning Under Uncertainty." Fuzzy Dynamic Programming (FDP) is usually designed to...and Composting Programs. Washington: Island Press, 1991. Junio, D.F. Development of an Analytical Hierarchy Process ( AHP ) Model for Siting of

Reducing the risk of falls through proprioceptive dynamic posture training in osteoporotic women with kyphotic posturing: a randomized pilot study.

PubMed

Sinaki, Mehrsheed; Lynn, Susan G

2002-04-01

To assess the effect of a proprioceptive dynamic posture training program on balance in osteoporotic women with kyphotic posture. Subjects were randomly assigned to either a proprioceptive dynamic posture training program or exercise only group. Anthropometric measurements, muscle strength, level of physical activity, computerized dynamic posturography, and spine radiography were performed at baseline and 1 mo. At the 1-mo follow-up, three groups were formed on the basis of the baseline computerized dynamic posturography results. In general, groups 1 and 2 had no significant change at 1 mo, whereas group 3 improved balance significantly at 1 mo. The subjects who had abnormal balance and used the proprioceptive dynamic posture training program had the most significant improvement in balance. Improved balance could reduce the risk of falls.

Generalized dynamic engine simulation techniques for the digital computer

NASA Technical Reports Server (NTRS)

Sellers, J.; Teren, F.

1974-01-01

Recently advanced simulation techniques have been developed for the digital computer and used as the basis for development of a generalized dynamic engine simulation computer program, called DYNGEN. This computer program can analyze the steady state and dynamic performance of many kinds of aircraft gas turbine engines. Without changes to the basic program, DYNGEN can analyze one- or two-spool turbofan engines. The user must supply appropriate component performance maps and design-point information. Examples are presented to illustrate the capabilities of DYNGEN in the steady state and dynamic modes of operation. The analytical techniques used in DYNGEN are briefly discussed, and its accuracy is compared with a comparable simulation using the hybrid computer. The impact of DYNGEN and similar all-digital programs on future engine simulation philosophy is also discussed.

Generalized dynamic engine simulation techniques for the digital computer

NASA Technical Reports Server (NTRS)

Sellers, J.; Teren, F.

1974-01-01

Recently advanced simulation techniques have been developed for the digital computer and used as the basis for development of a generalized dynamic engine simulation computer program, called DYNGEN. This computer program can analyze the steady state and dynamic performance of many kinds of aircraft gas turbine engines. Without changes to the basic program DYNGEN can analyze one- or two-spool turbofan engines. The user must supply appropriate component performance maps and design-point information. Examples are presented to illustrate the capabilities of DYNGEN in the steady state and dynamic modes of operation. The analytical techniques used in DYNGEN are briefly discussed, and its accuracy is compared with a comparable simulation using the hybrid computer. The impact of DYNGEN and similar all-digital programs on future engine simulation philosophy is also discussed.

Generalized dynamic engine simulation techniques for the digital computers

NASA Technical Reports Server (NTRS)

Sellers, J.; Teren, F.

1975-01-01

Recently advanced simulation techniques have been developed for the digital computer and used as the basis for development of a generalized dynamic engine simulation computer program, called DYNGEN. This computer program can analyze the steady state and dynamic performance of many kinds of aircraft gas turbine engines. Without changes to the basic program, DYNGEN can analyze one- or two-spool turbofan engines. The user must supply appropriate component performance maps and design point information. Examples are presented to illustrate the capabilities of DYNGEN in the steady state and dynamic modes of operation. The analytical techniques used in DYNGEN are briefly discussed, and its accuracy is compared with a comparable simulation using the hybrid computer. The impact of DYNGEN and similar digital programs on future engine simulation philosophy is also discussed.

Role Management, Educational Satisfaction, and Role Dynamics in Post-Secondary, Re-entry Women.

ERIC Educational Resources Information Center

Edmondon, Mary Ellen; And Others

1986-01-01

A sample of 42 post-secondary, educational re-entry women completed questionnaires focusing on background status, role dynamics, and satisfaction with their re-entry experience. Results showed no differences between students in a vocational program and those in a traditional, academic program. Role-dynamic variables--but not background-status…

Analysis, modeling, and simulation (AMS) testbed development and evaluation to support dynamic mobility applications (DMA) and active transportation and demand management (ATDM) programs — evaluation summary for ATDM program.

DOT National Transportation Integrated Search

2017-07-04

The primary objective of this project is to develop multiple simulation testbeds/transportation models to evaluate the impacts of Dynamic Mobility Application (DMA) connected vehicle applications and Active Transportation and Dynamic management (ATDM...

Optimal blood glucose level control using dynamic programming based on minimal Bergman model

NASA Astrophysics Data System (ADS)

Rettian Anggita Sari, Maria; Hartono

2018-03-01

The purpose of this article is to simulate the glucose dynamic and the insulin kinetic of diabetic patient. The model used in this research is a non-linear Minimal Bergman model. Optimal control theory is then applied to formulate the problem in order to determine the optimal dose of insulin in the treatment of diabetes mellitus such that the glucose level is in the normal range for some specific time range. The optimization problem is solved using dynamic programming. The result shows that dynamic programming is quite reliable to represent the interaction between glucose and insulin levels in diabetes mellitus patient.

Lean and Efficient Software: Whole-Program Optimization of Executables

DTIC Science & Technology

2015-09-30

libraries. Many levels of library interfaces—where some libraries are dynamically linked and some are provided in binary form only—significantly limit...software at build time. The opportunity: Our objective in this project is to substantially improve the performance, size, and robustness of binary ...executables by using static and dynamic binary program analysis techniques to perform whole-program optimization directly on compiled programs

Multi-mesh gear dynamics program evaluation and enhancements

NASA Technical Reports Server (NTRS)

Boyd, L. S.; Pike, J.

1985-01-01

A multiple mesh gear dynamics computer program was continually developed and modified during the last four years. The program can handle epicyclic gear systems as well as single mesh systems with internal, buttress, or helical tooth forms. The following modifications were added under the current funding: variable contact friction, planet cage and ring gear rim flexibility options, user friendly options, dynamic side bands, a speed survey option and the combining of the single and multiple mesh options into one general program. The modified program was evaluated by comparing calculated values to published test data and to test data taken on a Hamilton Standard turboprop reduction gear-box. In general, the correlation between the test data and the analytical data is good.

Integrated Dynamic Transit Operations (IDTO) concept of operations.

DOT National Transportation Integrated Search

2012-05-01

In support of USDOTs Intelligent Transportation Systems (ITS) Mobility Program, the Dynamic Mobility Applications (DMA) program seeks to create applications that fully leverage frequently collected and rapidly disseminated multi-source data gat...

Programmers manual for static and dynamic reusable surface insulation stresses (resist)

NASA Technical Reports Server (NTRS)

Ogilvie, P. L.; Levy, A.; Austin, F.; Ojalvo, I. U.

1974-01-01

Programming information for the RESIST program for the dynamic and thermal stress analysis of the space shuttle surface insulation is presented. The overall flow chart of the program, overlay chart, data set allocation, and subprogram calling sequence are given along with a brief description of the individual subprograms and typical subprogram output.

Satellite-tracking and earth-dynamics research programs. [geodetic and geophysical investigations and atmospheric research using satellite drag data

NASA Technical Reports Server (NTRS)

1972-01-01

Satellite tracking and earth dynamics research programs are discussed. Geodetic and geophysical investigations are reported along with atmospheric research using satellite drag data. Satellite tracking network functions and support groups which are discussed include: network operations, communications, data-services division, moonwatch, and programming group.

Dynamic Learning Objects to Teach Java Programming Language

ERIC Educational Resources Information Center

Narasimhamurthy, Uma; Al Shawkani, Khuloud

2010-01-01

This article describes a model for teaching Java Programming Language through Dynamic Learning Objects. The design of the learning objects was based on effective learning design principles to help students learn the complex topic of Java Programming. Visualization was also used to facilitate the learning of the concepts. (Contains 1 figure and 2…

Spaceflight dynamics 1993; AAS/NASA International Symposium, 8th, Greenbelt, MD, Apr. 26-30, 1993, Parts 1 & 2

NASA Technical Reports Server (NTRS)

Teles, Jerome (Editor); Samii, Mina V. (Editor)

1993-01-01

A conference on spaceflight dynamics produced papers in the areas of orbit determination, spacecraft tracking, autonomous navigation, the Deep Space Program Science Experiment Mission (DSPSE), the Global Positioning System, attitude control, geostationary satellites, interplanetary missions and trajectories, applications of estimation theory, flight dynamics systems, low-Earth orbit missions, orbital mechanics, mission experience in attitude dynamics, mission experience in sensor studies, attitude dynamics theory and simulations, and orbit-related experience. These papaers covered NASA, European, Russian, Japanese, Chinese, and Brazilian space programs and hardware.

Programming and memory dynamics of innate leukocytes during tissue homeostasis and inflammation.

PubMed

Lee, Christina; Geng, Shuo; Zhang, Yao; Rahtes, Allison; Li, Liwu

2017-09-01

The field of innate immunity is witnessing a paradigm shift regarding "memory" and "programming" dynamics. Past studies of innate leukocytes characterized them as first responders to danger signals with no memory. However, recent findings suggest that innate leukocytes, such as monocytes and neutrophils, are capable of "memorizing" not only the chemical nature but also the history and dosages of external stimulants. As a consequence, innate leukocytes can be dynamically programmed or reprogrammed into complex inflammatory memory states. Key examples of innate leukocyte memory dynamics include the development of primed and tolerant monocytes when "programmed" with a variety of inflammatory stimulants at varying signal strengths. The development of innate leukocyte memory may have far-reaching translational implications, as programmed innate leukocytes may affect the pathogenesis of both acute and chronic inflammatory diseases. This review intends to critically discuss some of the recent studies that address this emerging concept and its implication in the pathogenesis of inflammatory diseases. © Society for Leukocyte Biology.

The NASA Computational Fluid Dynamics (CFD) program - Building technology to solve future challenges

NASA Technical Reports Server (NTRS)

Richardson, Pamela F.; Dwoyer, Douglas L.; Kutler, Paul; Povinelli, Louis A.

1993-01-01

This paper presents the NASA Computational Fluid Dynamics program in terms of a strategic vision and goals as well as NASA's financial commitment and personnel levels. The paper also identifies the CFD program customers and the support to those customers. In addition, the paper discusses technical emphasis and direction of the program and some recent achievements. NASA's Ames, Langley, and Lewis Research Centers are the research hubs of the CFD program while the NASA Headquarters Office of Aeronautics represents and advocates the program.

Test readiness assessment summary for Integrated Dynamic Transit Operations (IDTO).

DOT National Transportation Integrated Search

2012-10-01

In support of USDOTs Intelligent Transportation Systems (ITS) Mobility Program, the Dynamic Mobility Applications (DMA) program seeks to create applications that fully leverage frequently collected and rapidly disseminated multi-source data gat...

User's Manual for Computer Program ROTOR. [to calculate tilt-rotor aircraft dynamic characteristics

NASA Technical Reports Server (NTRS)

Yasue, M.

1974-01-01

A detailed description of a computer program to calculate tilt-rotor aircraft dynamic characteristics is presented. This program consists of two parts: (1) the natural frequencies and corresponding mode shapes of the rotor blade and wing are developed from structural data (mass distribution and stiffness distribution); and (2) the frequency response (to gust and blade pitch control inputs) and eigenvalues of the tilt-rotor dynamic system, based on the natural frequencies and mode shapes, are derived. Sample problems are included to assist the user.

Research activities of the Geodynamics Branch

NASA Technical Reports Server (NTRS)

Kahn, W. D. (Editor); Cohen, S. C. (Editor)

1984-01-01

A broad spectrum of geoscience disciplines including space geodesy, geopotential field modeling, tectonophysics, and dynamic oceanography are discussed. The NASA programs, include the Geodynamics and Ocean Programs, the Crustal Dynamics Project, the proposed Ocean Topography Experiment (TOPEX), and the Geopotential Research Mission (GRM). The papers are grouped into chapters on Crustal Movements, Global Earth Dynamics, Gravity Field Model Development, Sea Surface Topography, and Advanced Studies.

Dynamics of WIC Program Participation by Infants and Children, 2001 to 2003. Final Report

ERIC Educational Resources Information Center

Castner, Laura; Mabli, James; Sykes, Julie

2009-01-01

The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) provides nutritious foods that promote the health of low-income pregnant women, new mothers, infants, and preschool children. This study examines WIC participation dynamics of infants and children from 2001 to 2003 using the Survey of Income and Program Participation…

Theory and Programs for Dynamic Modeling of Tree Rings from Climate

Treesearch

Paul C. van Deusen; Jennifer Koretz

1988-01-01

Computer programs written in GAUSS(TM) for IBM compatible personal computers are described that perform dynamic tree ring modeling with climate data; the underlying theory is also described. The programs and a separate users manual are available from the authors, although users must have the GAUSS software package on their personal computer. An example application of...

The Long-Run Effect of a Tax-Rebate Program

ERIC Educational Resources Information Center

Wang, Yuntong; Kasper, Hirschel

2007-01-01

In each period of a dynamic tax-rebate program, a (fixed) quantity tax is imposed on each unit of a given good, and the tax revenue is rebated back to the consumer in the next period. The program lasts for infinite number of periods. The author considers a representative consumer's dynamic consumption behavior, the long-run steady-state…

MATLAB implementation of a dynamic clamp with bandwidth >125 KHz capable of generating INa at 37°C

PubMed Central

Clausen, Chris; Valiunas, Virginijus; Brink, Peter R.; Cohen, Ira S.

2012-01-01

We describe the construction of a dynamic clamp with bandwidth >125 KHz that utilizes a high performance, yet low cost, standard home/office PC interfaced with a high-speed (16 bit) data acquisition module. High bandwidth is achieved by exploiting recently available software advances (code-generation technology, optimized real-time kernel). Dynamic-clamp programs are constructed using Simulink, a visual programming language. Blocks for computation of membrane currents are written in the high-level matlab language; no programming in C is required. The instrument can be used in single- or dual-cell configurations, with the capability to modify programs while experiments are in progress. We describe an algorithm for computing the fast transient Na+ current (INa) in real time, and test its accuracy and stability using rate constants appropriate for 37°C. We then construct a program capable of supplying three currents to a cell preparation: INa, the hyperpolarizing-activated inward pacemaker current (If), and an inward-rectifier K+ current (IK1). The program corrects for the IR drop due to electrode current flow, and also records all voltages and currents. We tested this program on dual patch-clamped HEK293 cells where the dynamic clamp controls a current-clamp amplifier and a voltage-clamp amplifier controls membrane potential, and current-clamped HEK293 cells where the dynamic clamp produces spontaneous pacing behavior exhibiting Na+ spikes in otherwise passive cells. PMID:23224681

Dynamic wavefront creation for processing units using a hybrid compactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Puthoor, Sooraj; Beckmann, Bradford M.; Yudanov, Dmitri

A method, a non-transitory computer readable medium, and a processor for repacking dynamic wavefronts during program code execution on a processing unit, each dynamic wavefront including multiple threads are presented. If a branch instruction is detected, a determination is made whether all wavefronts following a same control path in the program code have reached a compaction point, which is the branch instruction. If no branch instruction is detected in executing the program code, a determination is made whether all wavefronts following the same control path have reached a reconvergence point, which is a beginning of a program code segment tomore » be executed by both a taken branch and a not taken branch from a previous branch instruction. The dynamic wavefronts are repacked with all threads that follow the same control path, if all wavefronts following the same control path have reached the branch instruction or the reconvergence point.« less

Real-time stereo matching using orthogonal reliability-based dynamic programming.

PubMed

Gong, Minglun; Yang, Yee-Hong

2007-03-01

A novel algorithm is presented in this paper for estimating reliable stereo matches in real time. Based on the dynamic programming-based technique we previously proposed, the new algorithm can generate semi-dense disparity maps using as few as two dynamic programming passes. The iterative best path tracing process used in traditional dynamic programming is replaced by a local minimum searching process, making the algorithm suitable for parallel execution. Most computations are implemented on programmable graphics hardware, which improves the processing speed and makes real-time estimation possible. The experiments on the four new Middlebury stereo datasets show that, on an ATI Radeon X800 card, the presented algorithm can produce reliable matches for 60% approximately 80% of pixels at the rate of 10 approximately 20 frames per second. If needed, the algorithm can be configured for generating full density disparity maps.

Middle Atmosphere Program. Handbook for MAP, volume 27

NASA Technical Reports Server (NTRS)

Edwards, Belva (Editor)

1989-01-01

The proceedings are presented from the MAP program of July 1988. It is intended to be a quick synopsis of the symposium. General topics include: New International Equatorial Observatory; Dynamics of the Middle Atmosphere in Winter (DYNAMICS); Global Budget of Stratospheric Trace Constituents (GLOBUS); Gravity Waves and Turbulence in the Middle Atmosphere Program (GRATMAP); Middle Atmosphere Electrodynamics (MAE); Winter in Northern Europe (WINE); Atmospheric Tides Middle Atmosphere Program (ATMAP); and many others.

Ocean Thermal Energy Conversion power system development. Phase I: preliminary design. Final report. [ODSP-3 code; OTEC Steady-State Analysis Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1978-12-04

The following appendices are included; Dynamic Simulation Program (ODSP-3); sample results of dynamic simulation; trip report - NH/sub 3/ safety precautions/accident records; trip report - US Coast Guard Headquarters; OTEC power system development, preliminary design test program report; medium turbine generator inspection point program; net energy analysis; bus bar cost of electricity; OTEC technical specifications; and engineer drawings. (WHK)

Application of dynamic milling in stainless steel processing

NASA Astrophysics Data System (ADS)

Shan, Wenju

2017-09-01

This paper mainly introduces the method of parameter setting for NC programming of stainless steel parts by dynamic milling. Stainless steel is of high plasticity and toughness, serious hard working, large cutting force, high temperature in cutting area and easy wear of tool. It is difficult to process material. Dynamic motion technology is the newest NC programming technology of Mastercam software. It is an advanced machining idea. The tool path generated by the dynamic motion technology is more smooth, more efficient and more stable in the machining process. Dynamic motion technology is very suitable for cutting hard machining materials.

The effect of a rhythmic gymnastics program on the dynamic balance ability of individuals with intellectual disability.

PubMed

Fotiadou, Eleni G; Neofotistou, Konstantina H; Sidiropoulou, Maria P; Tsimaras, Vasilios K; Mandroukas, Athanasios K; Angelopoulou, Nickoletta A

2009-10-01

The purpose of this study was to examine the effect of a rhythmic gymnastics program on the dynamic balance ability of a group of adults with intellectual disability (ID). The sample consisted of 18 adults with ID. The control group consisted of 8 adults and an intervention group of 10. The subjects were assigned to each group according to their desire to participate or not in the intervention program. Both groups were comparable in terms of age, weight, height, IQ, and socioeconomic background. The intervention group received a 12-week rhythmic gymnastics program at a frequency of 3 lessons per week, of 45 minutes. The methods of data collection included pre/post-test measurements of the dynamic balance for all subjects of both groups. The dynamic balance ability was measured by means of a balance deck (Lafayette) and was determined by the number of seconds the subject could remain standing on the platform of the stabilometer in durations of 30-, 45-, and 60-second intervals. As the results indicated, the intervention group showed a statistically significant improvement (p < 0.05) in terms of dynamic balance ability in each interval after the application of the rhythmic gymnastics program when compared with the control group. It is concluded that adults with ID can improve their balance ability with the application of a well-designed rhythmic gymnastics program.

The Analysis of Forward and Backward Dynamic Programming for Multistage Graph

NASA Astrophysics Data System (ADS)

Sitinjak, Anna Angela; Pasaribu, Elvina; Simarmata, Justin E.; Putra, Tedy; Mawengkang, Herman

2018-01-01

Dynamic programming is an optimization approach that divides the complex problems into the simple sequences of problems in which they are interrelated leading to decisions. In the dynamic programming, there is no standard formula that can be used to make a certain formulation. In this paper we use forward and backward method to find path which have the minimum cost and to know whether they make the same final decision. Convert the problem into several successive sequential stages starting on from stages 1,2,3 and 4 for forward dynamic programming and the step back from stage 4.3,2,1 for backward dynamic programming and interconnected with a decision rule in each stage. Find the optimal solution with cost principle at next stage. Based on the characteristics of the dynamic programming, the case is divided into several stages and the decision is has to be made (xk) at each stage. The results obtained at a stage are used for the states in the next stage so that at the forward stage 1, f1 (s) is obtained and used as a consideration of the decision in the next stage. In the backward, used firstly stage 4, f4 (s) is obtained and used as a consideration of the decision in the next stage. Cost forward and backward always increase steadily, because the cost in the next stage depends on the cost in the previous stage and formed the decision of each stage by taking the smallest fk value. Therefore the forward and backward approaches have the same result.

A new 2D segmentation method based on dynamic programming applied to computer aided detection in mammography.

PubMed

Timp, Sheila; Karssemeijer, Nico

2004-05-01

Mass segmentation plays a crucial role in computer-aided diagnosis (CAD) systems for classification of suspicious regions as normal, benign, or malignant. In this article we present a robust and automated segmentation technique--based on dynamic programming--to segment mass lesions from surrounding tissue. In addition, we propose an efficient algorithm to guarantee resulting contours to be closed. The segmentation method based on dynamic programming was quantitatively compared with two other automated segmentation methods (region growing and the discrete contour model) on a dataset of 1210 masses. For each mass an overlap criterion was calculated to determine the similarity with manual segmentation. The mean overlap percentage for dynamic programming was 0.69, for the other two methods 0.60 and 0.59, respectively. The difference in overlap percentage was statistically significant. To study the influence of the segmentation method on the performance of a CAD system two additional experiments were carried out. The first experiment studied the detection performance of the CAD system for the different segmentation methods. Free-response receiver operating characteristics analysis showed that the detection performance was nearly identical for the three segmentation methods. In the second experiment the ability of the classifier to discriminate between malignant and benign lesions was studied. For region based evaluation the area Az under the receiver operating characteristics curve was 0.74 for dynamic programming, 0.72 for the discrete contour model, and 0.67 for region growing. The difference in Az values obtained by the dynamic programming method and region growing was statistically significant. The differences between other methods were not significant.

LAMMPS framework for dynamic bonding and an application modeling DNA

NASA Astrophysics Data System (ADS)

Svaneborg, Carsten

2012-08-01

We have extended the Large-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) to support directional bonds and dynamic bonding. The framework supports stochastic formation of new bonds, breakage of existing bonds, and conversion between bond types. Bond formation can be controlled to limit the maximal functionality of a bead with respect to various bond types. Concomitant with the bond dynamics, angular and dihedral interactions are dynamically introduced between newly connected triplets and quartets of beads, where the interaction type is determined from the local pattern of bead and bond types. When breaking bonds, all angular and dihedral interactions involving broken bonds are removed. The framework allows chemical reactions to be modeled, and use it to simulate a simplistic, coarse-grained DNA model. The resulting DNA dynamics illustrates the power of the present framework. Catalogue identifier: AEME_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEME_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public Licence No. of lines in distributed program, including test data, etc.: 2 243 491 No. of bytes in distributed program, including test data, etc.: 771 Distribution format: tar.gz Programming language: C++ Computer: Single and multiple core servers Operating system: Linux/Unix/Windows Has the code been vectorized or parallelized?: Yes. The code has been parallelized by the use of MPI directives. RAM: 1 Gb Classification: 16.11, 16.12 Nature of problem: Simulating coarse-grain models capable of chemistry e.g. DNA hybridization dynamics. Solution method: Extending LAMMPS to handle dynamic bonding and directional bonds. Unusual features: Allows bonds to be created and broken while angular and dihedral interactions are kept consistent. Additional comments: The distribution file for this program is approximately 36 Mbytes and therefore is not delivered directly when download or E-mail is requested. Instead an html file giving details of how the program can be obtained is sent. Running time: Hours to days. The examples provided in the distribution take just seconds to run.

Project implementation plan : variable dynamic testbed vehicle

DOT National Transportation Integrated Search

1997-02-01

This document is the project implementation plan for the Variable Dynamic Testbed Vehicle (VDTV) program, sponsored by the Jet Propulsion Laboratory for the Office of Crash Avoidance Research (OCAR) programs in support of Thrust One of the National H...

Satellite-tracking and earth-dynamics research programs

NASA Technical Reports Server (NTRS)

1975-01-01

The activities and progress in the satellite tracking and earth dynamics research during the first half of calendar year 1975 are described. Satellite tracking network operations, satellite geodesy and geophysics programs, GEOS 3 project support, and atmospheric research are covered.

Dynamic mobility applications, program evaluation : national-level impacts and costs estimation : final report.

DOT National Transportation Integrated Search

2016-07-01

The vision of the Dynamic Mobility Applications (DMA) program is to expedite the development, testing, and deployment of innovative mobility applications that maximize system productivity and enhance mobility of individuals within the surface transpo...

Structures and Dynamics Division research and technology plans, fiscal year, 1981

NASA Technical Reports Server (NTRS)

Bales, K. S.

1981-01-01

The objectives, expected results, approach, and FY 81 milestones for the Structures and Dynamics Division's research program are presented. This information will be useful in program coordination with other government organizations in areas of mutual interest.

Six degree of freedom FORTRAN program, ASTP docking dynamics, users guide

NASA Technical Reports Server (NTRS)

Mount, G. O., Jr.; Mikhalkin, B.

1974-01-01

The digital program ASTP Docking Dynamics as outlined is intended to aid the engineer using the program to determine the docking system loads and attendant vehicular motion resulting from docking two vehicles that have an androgynous, six-hydraulic-attenuator, guide ring, docking interface similar to that designed for the Apollo/Soyuz Test Project (ASTP). This program is set up to analyze two different vehicle combinations: the Apollo CSM docking to Soyuz and the shuttle orbiter docking to another orbiter. The subroutine modifies the vehicle control systems to describe one or the other vehicle combinations; the rest of the vehicle characteristics are changed by input data. To date, the program has been used to predict and correlate ASTP docking loads and performance with docking test program results from dynamic testing. The program modified for use on IBM 360 computers. Parts of the original docking system equations in the areas of hydraulic damping and capture latches are modified to better describe the detail design of the ASTP docking system.

A NASTRAN/TREETOPS solution to a flexible, multi-body dynamics and controls problem on a UNIX workstation

NASA Technical Reports Server (NTRS)

Benavente, Javier E.; Luce, Norris R.

1989-01-01

Demands for nonlinear time history simulations of large, flexible multibody dynamic systems has created a need for efficient interfaces between finite-element modeling programs and time-history simulations. One such interface, TREEFLX, an interface between NASTRAN and TREETOPS, a nonlinear dynamics and controls time history simulation for multibody structures, is presented and demonstrated via example using the proposed Space Station Mobile Remote Manipulator System (MRMS). The ability to run all three programs (NASTRAN, TREEFLX and TREETOPS), in addition to other programs used for controller design and model reduction (such as DMATLAB and TREESEL, both described), under a UNIX Workstation environment demonstrates the flexibility engineers now have in designing, developing and testing control systems for dynamically complex systems.

Parallel Programming Strategies for Irregular Adaptive Applications

NASA Technical Reports Server (NTRS)

Biswas, Rupak; Biegel, Bryan (Technical Monitor)

2001-01-01

Achieving scalable performance for dynamic irregular applications is eminently challenging. Traditional message-passing approaches have been making steady progress towards this goal; however, they suffer from complex implementation requirements. The use of a global address space greatly simplifies the programming task, but can degrade the performance for such computations. In this work, we examine two typical irregular adaptive applications, Dynamic Remeshing and N-Body, under competing programming methodologies and across various parallel architectures. The Dynamic Remeshing application simulates flow over an airfoil, and refines localized regions of the underlying unstructured mesh. The N-Body experiment models two neighboring Plummer galaxies that are about to undergo a merger. Both problems demonstrate dramatic changes in processor workloads and interprocessor communication with time; thus, dynamic load balancing is a required component.

INFORM: An interactive data collection and display program with debugging capability

NASA Technical Reports Server (NTRS)

Cwynar, D. S.

1980-01-01

A computer program was developed to aid ASSEMBLY language programmers of mini and micro computers in solving the man machine communications problems that exist when scaled integers are involved. In addition to producing displays of quasi-steady state values, INFORM provides an interactive mode for debugging programs, making program patches, and modifying the displays. Auxiliary routines SAMPLE and DATAO add dynamic data acquisition and high speed dynamic display capability to the program. Programming information and flow charts to aid in implementing INFORM on various machines together with descriptions of all supportive software are provided. Program modifications to satisfy the individual user's needs are considered.

Analysis of the Dynamics among Tutors in an After-School Tutoring Program in a Homeless Shelter for Families

ERIC Educational Resources Information Center

MacGillivray, Laurie; Goode, Gretchen S.

2016-01-01

Researchers of after-school tutoring primarily focus on educational outcomes with little attention to the social dynamics of such programs. In our qualitative case study, we examined the nature of interactions among tutors in a tutoring program at a homeless shelter for families. Employing Bourdieu's concepts of "social capital" and…

Dynamics of a Successful Planned Giving Program Utilizing Shared Leadership at Historically Black Colleges and Universities (HBCUs)

ERIC Educational Resources Information Center

Baldwin, Robin Lynn Brunty

2013-01-01

The purpose of this study was to evaluate the dynamics of a successful planned giving program utilizing shared leadership at Historically Black Colleges and Universities (HBCUs). This information will assist the leadership in determining if and how a successful planned giving program can be established for HBCUs. It is possible for planned gifts…

Effects of virtual reality programs on balance in functional ankle instability

PubMed Central

Kim, Ki-Jong; Heo, Myoung

2015-01-01

[Purpose] The aim of present study was to identify the impact that recent virtual reality training programs used in a variety of fields have had on the ankle’s static and dynamic senses of balance among subjects with functional ankle instability. [Subjects and Methods] This study randomly divided research subjects into two groups, a strengthening exercise group (Group I) and a balance exercise group (Group II), with each group consisting of 10 people. A virtual reality program was performed three times a week for four weeks. Exercises from the Nintendo Wii Fit Plus program were applied to each group for twenty minutes along with ten minutes of warming up and wrap-up exercises. [Results] Group II showed a significant decrease of post-intervention static and dynamic balance overall in the anterior-posterior, and mediolateral directions, compared with the pre-intervention test results. In comparison of post-intervention static and dynamic balance between Group I and Group II, a significant decrease was observed overall. [Conclusion] Virtual reality programs improved the static balance and dynamic balance of subjects with functional ankle instability. Virtual reality programs can be used more safely and efficiently if they are implemented under appropriate monitoring by a physiotherapist. PMID:26644652

Effects of virtual reality programs on balance in functional ankle instability.

PubMed

Kim, Ki-Jong; Heo, Myoung

2015-10-01

[Purpose] The aim of present study was to identify the impact that recent virtual reality training programs used in a variety of fields have had on the ankle's static and dynamic senses of balance among subjects with functional ankle instability. [Subjects and Methods] This study randomly divided research subjects into two groups, a strengthening exercise group (Group I) and a balance exercise group (Group II), with each group consisting of 10 people. A virtual reality program was performed three times a week for four weeks. Exercises from the Nintendo Wii Fit Plus program were applied to each group for twenty minutes along with ten minutes of warming up and wrap-up exercises. [Results] Group II showed a significant decrease of post-intervention static and dynamic balance overall in the anterior-posterior, and mediolateral directions, compared with the pre-intervention test results. In comparison of post-intervention static and dynamic balance between Group I and Group II, a significant decrease was observed overall. [Conclusion] Virtual reality programs improved the static balance and dynamic balance of subjects with functional ankle instability. Virtual reality programs can be used more safely and efficiently if they are implemented under appropriate monitoring by a physiotherapist.

The investigation of tethered satellite system dynamics

NASA Technical Reports Server (NTRS)

Lorenzini, E.

1985-01-01

A progress report is presented that deals with three major topics related to Tethered Satellite System Dynamics. The SAO rotational dynamics computer code was updated. The program is now suitable to deal with inclined orbits. The output has been also modified in order to show the satellite Euler angles referred to the rotating orbital frame. The three-dimensional high resolution computer program SLACK3 was developed. The code simulates the three-dimensional dynamics of a tether going slack taking into account the effect produced by boom rotations. Preliminary simulations on the three-dimensional dynamics of a recoiling slack tether are shown in this report. A program to evaluate the electric potential around a severed tether is immersed in a plasma. The potential is computed on a three-dimensional grid axially symmetric with respect to the tether longitudinal axis. The electric potential variations due to the plasma are presently under investigation.

NASTRAN analysis of the 1/8-scale space shuttle dynamic model

NASA Technical Reports Server (NTRS)

Bernstein, M.; Mason, P. W.; Zalesak, J.; Gregory, D. J.; Levy, A.

1973-01-01

The space shuttle configuration has more complex structural dynamic characteristics than previous launch vehicles primarily because of the high model density at low frequencies and the high degree of coupling between the lateral and longitudinal motions. An accurate analytical representation of these characteristics is a primary means for treating structural dynamics problems during the design phase of the shuttle program. The 1/8-scale model program was developed to explore the adequacy of available analytical modeling technology and to provide the means for investigating problems which are more readily treated experimentally. The basic objectives of the 1/8-scale model program are: (1) to provide early verification of analytical modeling procedures on a shuttle-like structure, (2) to demonstrate important vehicle dynamic characteristics of a typical shuttle design, (3) to disclose any previously unanticipated structural dynamic characteristics, and (4) to provide for development and demonstration of cost effective prototype testing procedures.

Report on stakeholder input on transformational goals, performance measures and user needs for integrated dynamic transit operations.

DOT National Transportation Integrated Search

2012-03-01

In support of USDOTs Intelligent Transportation Systems (ITS) Mobility Program, the Dynamic Mobility Applications (DMA) program seeks to create applications that fully leverage frequently collected and rapidly disseminated multi-source data gat...

Data compression of discrete sequence: A tree based approach using dynamic programming

NASA Technical Reports Server (NTRS)

Shivaram, Gurusrasad; Seetharaman, Guna; Rao, T. R. N.

1994-01-01

A dynamic programming based approach for data compression of a ID sequence is presented. The compression of an input sequence of size N to that of a smaller size k is achieved by dividing the input sequence into k subsequences and replacing the subsequences by their respective average values. The partitioning of the input sequence is carried with the intention of reducing the mean squared error in the reconstructed sequence. The complexity involved in finding the partitions which would result in such an optimal compressed sequence is reduced by using the dynamic programming approach, which is presented.

Optimal blood glucose control in diabetes mellitus treatment using dynamic programming based on Ackerman’s linear model

NASA Astrophysics Data System (ADS)

Pradanti, Paskalia; Hartono

2018-03-01

Determination of insulin injection dose in diabetes mellitus treatment can be considered as an optimal control problem. This article is aimed to simulate optimal blood glucose control for patient with diabetes mellitus. The blood glucose regulation of diabetic patient is represented by Ackerman’s Linear Model. This problem is then solved using dynamic programming method. The desired blood glucose level is obtained by minimizing the performance index in Lagrange form. The results show that dynamic programming based on Ackerman’s Linear Model is quite good to solve the problem.

Risk-Sensitive Control of Pure Jump Process on Countable Space with Near Monotone Cost

DOE Office of Scientific and Technical Information (OSTI.GOV)

Suresh Kumar, K., E-mail: suresh@math.iitb.ac.in; Pal, Chandan, E-mail: cpal@math.iitb.ac.in

2013-12-15

In this article, we study risk-sensitive control problem with controlled continuous time pure jump process on a countable space as state dynamics. We prove multiplicative dynamic programming principle, elliptic and parabolic Harnack’s inequalities. Using the multiplicative dynamic programing principle and the Harnack’s inequalities, we prove the existence and a characterization of optimal risk-sensitive control under the near monotone condition.

A comprehensive analytical model of rotorcraft aerodynamics and dynamics. Part 2: User's manual

NASA Technical Reports Server (NTRS)

Johnson, W.

1980-01-01

The use of a computer program for a comprehensive analytical model of rotorcraft aerodynamics and dynamics is described. The program calculates the loads and motion of helicopter rotors and airframe. First the trim solution is obtained, then the flutter, flight dynamics, and/or transient behavior can be calculated. Either a new job can be initiated or further calculations can be performed for an old job.

Multiplicity of the 660-km discontinuity beneath the Izu-Bonin area

NASA Astrophysics Data System (ADS)

Zhou, Yuan-Ze; Yu, Xiang-Wei; Yang, Hui; Zang, Shao-Xian

2012-05-01

The relatively simple subducting slab geometry in the Izu-Bonin region provides a valuable opportunity to study the multiplicity of the 660-km discontinuity and the related response of the subducting slab on the discontinuity. Vertical short-period recordings of deep events with simple direct P phases beneath the Izu-Bonin region were retrieved from two seismic networks in the western USA and were used to study the structure of the 660-km discontinuity. After careful selection and pre-processing, 23 events from the networks, forming 32 pairs of event-network records, were processed. Related vespagrams were produced using the N-th root slant stack method for detecting weak down-going SdP phases that were inverted to the related conversion points. From depth histograms and the spatial distribution of the conversion points, there were three clear interfaces at depths of 670, 710 and 730 km. These interfaces were depressed approximately 20-30 km in the northern region. In the southern region, only two layers were identified in the depth histograms, and no obvious layered structure could be observed from the distribution of the conversion points.

A distributed approach to the OPF problem

NASA Astrophysics Data System (ADS)

Erseghe, Tomaso

2015-12-01

This paper presents a distributed approach to optimal power flow (OPF) in an electrical network, suitable for application in a future smart grid scenario where access to resource and control is decentralized. The non-convex OPF problem is solved by an augmented Lagrangian method, similar to the widely known ADMM algorithm, with the key distinction that penalty parameters are constantly increased. A (weak) assumption on local solver reliability is required to always ensure convergence. A certificate of convergence to a local optimum is available in the case of bounded penalty parameters. For moderate sized networks (up to 300 nodes, and even in the presence of a severe partition of the network), the approach guarantees a performance very close to the optimum, with an appreciably fast convergence speed. The generality of the approach makes it applicable to any (convex or non-convex) distributed optimization problem in networked form. In the comparison with the literature, mostly focused on convex SDP approximations, the chosen approach guarantees adherence to the reference problem, and it also requires a smaller local computational complexity effort.

Step changes in leaf oil accumulation via iterative metabolic engineering.

PubMed

Vanhercke, Thomas; Divi, Uday K; El Tahchy, Anna; Liu, Qing; Mitchell, Madeline; Taylor, Matthew C; Eastmond, Peter J; Bryant, Fiona; Mechanicos, Anna; Blundell, Cheryl; Zhi, Yao; Belide, Srinivas; Shrestha, Pushkar; Zhou, Xue-Rong; Ral, Jean-Philippe; White, Rosemary G; Green, Allan; Singh, Surinder P; Petrie, James R

2017-01-01

Synthesis and accumulation of plant oils in the entire vegetative biomass offers the potential to deliver yields surpassing those of oilseed crops. However, current levels still fall well short of those typically found in oilseeds. Here we show how transcriptome and biochemical analyses pointed to a futile cycle in a previously established Nicotiana tabacum line, accumulating up to 15% (dry weight) of the storage lipid triacylglycerol in leaf tissue. To overcome this metabolic bottleneck, we either silenced the SDP1 lipase or overexpressed the Arabidopsis thaliana LEC2 transcription factor in this transgenic background. Both strategies independently resulted in the accumulation of 30-33% triacylglycerol in leaf tissues. Our results demonstrate that the combined optimization of de novo fatty acid biosynthesis, storage lipid assembly and lipid turnover in leaf tissue results in a major overhaul of the plant central carbon allocation and lipid metabolism. The resulting further step changes in oil accumulation in the entire plant biomass offers the possibility of delivering yields that outperform current oilseed crops. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Training Vocational Rehabilitation Counselors in Group Dynamics: A Psychoeducational Model.

ERIC Educational Resources Information Center

Elliott, Timothy R.

1990-01-01

Describes a six-session psychoeducational program for training vocational rehabilitation counselors in group dynamics. Presents evaluation of program by counselors (N=15) in which leadership styles, conflict management, and typology of group tasks concepts were rated as most beneficial. (Author/ABL)

CARBON DYNAMICS OF THE CONSERVATION AND WETLAND RESERVE PROGRAMS

EPA Science Inventory

Data from the Conservation (CRP) and Wetland (WRP) Reserve Programs were analyzed to quantify the carbon (C) dynamics of associated cropland converted to grassland or forestland. Land-area enrollments were multiplied by grassland- and forestland-C densities to calculate C pools a...

Dynamic Test Program, Contact Power Collection for High Speed Tracked Vehicles

DOT National Transportation Integrated Search

1973-01-01

A laboratory test program is defined for determining the dynamic characteristics of a contact power collection system for a high speed tracked vehicle. The use of a hybrid computer is conjuntion with hydraulic exciters to simulate the expected dynami...

Report on functional and performance requirements, and high-level data and communication needs for integrated dynamic transit operations (IDTO).

DOT National Transportation Integrated Search

2012-08-01

In support of USDOTs Intelligent Transportation Systems (ITS) Mobility Program, the Dynamic Mobility Applications (DMA) program seeks to create applications that fully leverage frequently collected and rapidly disseminated multi-source data gat...

Assessment of relevant prior and ongoing research for the concept development and needs identification for integrated dynamic transit operations.

DOT National Transportation Integrated Search

2011-11-01

In support of USDOTs Intelligent Transportation Systems (ITS) Mobility Program, the Dynamic Mobility Applications (DMA) program seeks to create applications that fully leverage frequently collected and rapidly disseminated multi-source data gat...

DRACULA: Dynamic range control for broadcasting and other applications

NASA Astrophysics Data System (ADS)

Gilchrist, N. H. C.

The BBC has developed a digital processor which is capable of reducing the dynamic range of audio in an unobtrusive manner. It is ideally suited to the task of controlling the level of musical programs. Operating as a self-contained dynamic range controller, the processor is suitable for controlling levels in conventional AM or FM broadcasting, or for applications such as the compression of program material for in-flight entertainment. It can, alternatively, be used to provide a supplementary signal in DAB (digital audio broadcasting) for optional dynamic compression in the receiver.

Dynamic UNITY

DTIC Science & Technology

2002-01-01

UNITY program that implements exactly the same algorithm as Specification 1.1. The correctness of this program is proven in amanner sim- 4 program...chapter, we introduce the Dynamic UNITY formalism, which allows us to reason about algorithms and protocols in which the sets of participating processes...implements Euclid’s algorithm for calculating the greatest common divisor (GCD) of two integers; it repeat- edly reads an integer message from each of its

User's guide for a revised computer program to analyze the LRC 16 foot transonic dynamics tunnel active cable mount system. [computer techniques - aircraft models

NASA Technical Reports Server (NTRS)

Chin, J.; Barbero, P.

1975-01-01

The revision of an existing digital program to analyze the stability of models mounted on a two-cable mount system used in a transonic dynamics wind tunnel is presented. The program revisions and analysis of an active feedback control system to be used for controlling the free-flying models are treated.

Efficient dynamic optimization of logic programs

NASA Technical Reports Server (NTRS)

Laird, Phil

1992-01-01

A summary is given of the dynamic optimization approach to speed up learning for logic programs. The problem is to restructure a recursive program into an equivalent program whose expected performance is optimal for an unknown but fixed population of problem instances. We define the term 'optimal' relative to the source of input instances and sketch an algorithm that can come within a logarithmic factor of optimal with high probability. Finally, we show that finding high-utility unfolding operations (such as EBG) can be reduced to clause reordering.

Life and dynamic capacity modeling for aircraft transmissions

NASA Technical Reports Server (NTRS)

Savage, Michael

1991-01-01

A computer program to simulate the dynamic capacity and life of parallel shaft aircraft transmissions is presented. Five basic configurations can be analyzed: single mesh, compound, parallel, reverted, and single plane reductions. In execution, the program prompts the user for the data file prefix name, takes input from a ASCII file, and writes its output to a second ASCII file with the same prefix name. The input data file includes the transmission configuration, the input shaft torque and speed, and descriptions of the transmission geometry and the component gears and bearings. The program output file describes the transmission, its components, their capabilities, locations, and loads. It also lists the dynamic capability, ninety percent reliability, and mean life of each component and the transmission as a system. Here, the program, its input and output files, and the theory behind the operation of the program are described.

Study Trapped Charge Distribution in P-Channel Silicon-Oxide-Nitride-Oxide-Silicon Memory Device Using Dynamic Programming Scheme

NASA Astrophysics Data System (ADS)

Li, Fu-Hai; Chiu, Yung-Yueh; Lee, Yen-Hui; Chang, Ru-Wei; Yang, Bo-Jun; Sun, Wein-Town; Lee, Eric; Kuo, Chao-Wei; Shirota, Riichiro

2013-04-01

In this study, we precisely investigate the charge distribution in SiN layer by dynamic programming of channel hot hole induced hot electron injection (CHHIHE) in p-channel silicon-oxide-nitride-oxide-silicon (SONOS) memory device. In the dynamic programming scheme, gate voltage is increased as a staircase with fixed step amplitude, which can prohibits the injection of holes in SiN layer. Three-dimensional device simulation is calibrated and is compared with the measured programming characteristics. It is found, for the first time, that the hot electron injection point quickly traverses from drain to source side synchronizing to the expansion of charged area in SiN layer. As a result, the injected charges quickly spread over on the almost whole channel area uniformly during a short programming period, which will afford large tolerance against lateral trapped charge diffusion by baking.

Dynamic analysis for solid waste management systems: an inexact multistage integer programming approach.

PubMed

Li, Yongping; Huang, Guohe

2009-03-01

In this study, a dynamic analysis approach based on an inexact multistage integer programming (IMIP) model is developed for supporting municipal solid waste (MSW) management under uncertainty. Techniques of interval-parameter programming and multistage stochastic programming are incorporated within an integer-programming framework. The developed IMIP can deal with uncertainties expressed as probability distributions and interval numbers, and can reflect the dynamics in terms of decisions for waste-flow allocation and facility-capacity expansion over a multistage context. Moreover, the IMIP can be used for analyzing various policy scenarios that are associated with different levels of economic consequences. The developed method is applied to a case study of long-term waste-management planning. The results indicate that reasonable solutions have been generated for binary and continuous variables. They can help generate desired decisions of system-capacity expansion and waste-flow allocation with a minimized system cost and maximized system reliability.

Application of the ADAMS program to deployable space truss structures

NASA Technical Reports Server (NTRS)

Calleson, R. E.

1985-01-01

The need for a computer program to perform kinematic and dynamic analyses of large truss structures while deploying from a packaged configuration in space led to the evaluation of several existing programs. ADAMS (automatic dynamic analysis of mechanical systems), a generalized program from performing the dynamic simulation of mechanical systems undergoing large displacements, is applied to two concepts of deployable space antenna units. One concept is a one cube folding unit of Martin Marietta's Box Truss Antenna and the other is a tetrahedral truss unit of a Tetrahedral Truss Antenna. Adequate evaluation of dynamic forces during member latch-up into the deployed configuration is not yet available from the present version of ADAMS since it is limited to the assembly of rigid bodies. Included is a method for estimating the maximum bending stress in a surface member at latch-up. Results include member displacement and velocity responses during extension and an example of member bending stresses at latch-up.

DORCA 2 computer program. Volume 3: Program listing

NASA Technical Reports Server (NTRS)

Carey, J. B.

1972-01-01

A program listing for the Dynamic Operational Requirements and Cost Analysis Program is presented. Detailed instructions for the computer programming involved in space mission planning and project requirements are developed.

The Solar Dynamics Observatory (SDO) Education and Outreach (E/PO) Program: Changing Perceptions One Program at a Time

NASA Technical Reports Server (NTRS)

Drobnes, Emilie; Littleton, A.; Pesnell, William D.; Beck, K.; Buhr, S.; Durscher, R.; Hill, S.; McCaffrey, M.; McKenzie, D. E.; Myers, D.;

The Synthetic Aperture Radar Science Data Processing Foundry Concept for Earth Science

NASA Astrophysics Data System (ADS)

Rosen, P. A.; Hua, H.; Norton, C. D.; Little, M. M.

2015-12-01

Since 2008, NASA's Earth Science Technology Office and the Advanced Information Systems Technology Program have invested in two technology evolutions to meet the needs of the community of scientists exploiting the rapidly growing database of international synthetic aperture radar (SAR) data. JPL, working with the science community, has developed the InSAR Scientific Computing Environment (ISCE), a next-generation interferometric SAR processing system that is designed to be flexible and extensible. ISCE currently supports many international space borne data sets but has been primarily focused on geodetic science and applications. A second evolutionary path, the Advanced Rapid Imaging and Analysis (ARIA) science data system, uses ISCE as its core science data processing engine and produces automated science and response products, quality assessments and metadata. The success of this two-front effort has been demonstrated in NASA's ability to respond to recent events with useful disaster support. JPL has enabled high-volume and low latency data production by the re-use of the hybrid cloud computing science data system (HySDS) that runs ARIA, leveraging on-premise cloud computing assets that are able to burst onto the Amazon Web Services (AWS) services as needed. Beyond geodetic applications, needs have emerged to process large volumes of time-series SAR data collected for estimation of biomass and its change, in such campaigns as the upcoming AfriSAR field campaign. ESTO is funding JPL to extend the ISCE-ARIA model to a "SAR Science Data Processing Foundry" to on-ramp new data sources and to produce new science data products to meet the needs of science teams and, in general, science community members. An extension of the ISCE-ARIA model to support on-demand processing will permit PIs to leverage this Foundry to produce data products from accepted data sources when they need them. This paper will describe each of the elements of the SAR SDP Foundry and describe their integration into a new conceptual approach to enable more effective use of SAR instruments.

A space-efficient algorithm for local similarities.

PubMed

Huang, X Q; Hardison, R C; Miller, W

1990-10-01

Existing dynamic-programming algorithms for identifying similar regions of two sequences require time and space proportional to the product of the sequence lengths. Often this space requirement is more limiting than the time requirement. We describe a dynamic-programming local-similarity algorithm that needs only space proportional to the sum of the sequence lengths. The method can also find repeats within a single long sequence. To illustrate the algorithm's potential, we discuss comparison of a 73,360 nucleotide sequence containing the human beta-like globin gene cluster and a corresponding 44,594 nucleotide sequence for rabbit, a problem well beyond the capabilities of other dynamic-programming software.

Parallel Optimization of Polynomials for Large-scale Problems in Stability and Control

NASA Astrophysics Data System (ADS)

Kamyar, Reza

In this thesis, we focus on some of the NP-hard problems in control theory. Thanks to the converse Lyapunov theory, these problems can often be modeled as optimization over polynomials. To avoid the problem of intractability, we establish a trade off between accuracy and complexity. In particular, we develop a sequence of tractable optimization problems --- in the form of Linear Programs (LPs) and/or Semi-Definite Programs (SDPs) --- whose solutions converge to the exact solution of the NP-hard problem. However, the computational and memory complexity of these LPs and SDPs grow exponentially with the progress of the sequence - meaning that improving the accuracy of the solutions requires solving SDPs with tens of thousands of decision variables and constraints. Setting up and solving such problems is a significant challenge. The existing optimization algorithms and software are only designed to use desktop computers or small cluster computers --- machines which do not have sufficient memory for solving such large SDPs. Moreover, the speed-up of these algorithms does not scale beyond dozens of processors. This in fact is the reason we seek parallel algorithms for setting-up and solving large SDPs on large cluster- and/or super-computers. We propose parallel algorithms for stability analysis of two classes of systems: 1) Linear systems with a large number of uncertain parameters; 2) Nonlinear systems defined by polynomial vector fields. First, we develop a distributed parallel algorithm which applies Polya's and/or Handelman's theorems to some variants of parameter-dependent Lyapunov inequalities with parameters defined over the standard simplex. The result is a sequence of SDPs which possess a block-diagonal structure. We then develop a parallel SDP solver which exploits this structure in order to map the computation, memory and communication to a distributed parallel environment. Numerical tests on a supercomputer demonstrate the ability of the algorithm to efficiently utilize hundreds and potentially thousands of processors, and analyze systems with 100+ dimensional state-space. Furthermore, we extend our algorithms to analyze robust stability over more complicated geometries such as hypercubes and arbitrary convex polytopes. Our algorithms can be readily extended to address a wide variety of problems in control such as Hinfinity synthesis for systems with parametric uncertainty and computing control Lyapunov functions.

HEMP 3D: A finite difference program for calculating elastic-plastic flow, appendix B

NASA Astrophysics Data System (ADS)

Wilkins, Mark L.

1993-05-01

The HEMP 3D program can be used to solve problems in solid mechanics involving dynamic plasticity and time dependent material behavior and problems in gas dynamics. The equations of motion, the conservation equations, and the constitutive relations listed below are solved by finite difference methods following the format of the HEMP computer simulation program formulated in two space dimensions and time.

Industrial Technology Modernization Program. Project 28. Automation of Receiving, Receiving Inspection and Stores

DTIC Science & Technology

1987-06-15

001 GENERAL DYNAMICS 00 FORT WORTH DIVISION INDUSTRIAL TECHNOLOGY MODERNIZATION PROGRAM Phase 2 Final Project Repc t JUNG 0 ?7 PROJECT 28 AUTOMATION...DYNAMICS FORT WORTH DIVISION INDUSTRIAL TECHNOLOGY MODERNIZATION PROGRAM Phase 2 Final Project Report PROJECT 28 AUTOMATION OF RECEIVING, RECEIVING...13 6 PROJECT ASSUMPTIONS 20 7 PRELIMINARY/FINAL DESIGN AND FINDINGS 21 8 SYSTEM/EQUIPMENT/MACHINING SPECIFICATIONS 37 9 VENDOR/ INDUSTRY ANALYSIS

Visualization of fluid dynamics at NASA Ames

NASA Technical Reports Server (NTRS)

Watson, Val

1989-01-01

The hardware and software currently used for visualization of fluid dynamics at NASA Ames is described. The software includes programs to create scenes (for example particle traces representing the flow over an aircraft), programs to interactively view the scenes, and programs to control the creation of video tapes and 16mm movies. The hardware includes high performance graphics workstations, a high speed network, digital video equipment, and film recorders.

Mississippi Curriculum Framework for Family Dynamics. Secondary Programs.

ERIC Educational Resources Information Center

Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for family dynamics. The course uses skills in critical thinking, decision…

Investigation of the Dynamics of a Maglev Vehicle Traversing a Flexible Guideway : Theory and Experiment

DOT National Transportation Integrated Search

1979-04-01

This report presents the results of a research program conducted jointly by the United States Department of Transportation and the Federal Republic of Germany Ministry for Research and Technology. The object of this program was to study the dynamics ...

A Symbolic and Graphical Computer Representation of Dynamical Systems

NASA Astrophysics Data System (ADS)

Gould, Laurence I.

2005-04-01

AUTONO is a Macsyma/Maxima program, designed at the University of Hartford, for solving autonomous systems of differential equations as well as for relating Lagrangians and Hamiltonians to their associated dynamical equations. AUTONO can be used in a number of fields to decipher a variety of complex dynamical systems with ease, producing their Lagrangian and Hamiltonian equations in seconds. These equations can then be incorporated into VisSim, a modeling and simulation program, which yields graphical representations of motion in a given system through easily chosen input parameters. The program, along with the VisSim differential-equations graphical package, allows for resolution and easy understanding of complex problems in a relatively short time; thus enabling quicker and more advanced computing of dynamical systems on any number of platforms---from a network of sensors on a space probe, to the behavior of neural networks, to the effects of an electromagnetic field on components in a dynamical system. A flowchart of AUTONO, along with some simple applications and VisSim output, will be shown.

DEAN: A Program for Dynamic Engine Analysis.

DTIC Science & Technology

1985-01-01

hardware and memory limitations. DIGTEM (ref. 4), a recently written code allows steady-state as well as transient calculations to be performed. DIGTEM has...Computer Program for Generating Dynamic Turbofan Engine Models ( DIGTEM )," NASA TM-83446. 5. Carnahan, B., Luther, H.A., and Wilkes, J.O., Applied Numerical

Structures and Dynamics Division research and technology plans for FY 1986 and accomplishments for FY 1985

NASA Technical Reports Server (NTRS)

Bales, K. S.

1986-01-01

Presented are the Objectives, FY 1986 Plans, Approach, and FY 1986 Milestones for the Structures and Dynamics Division's research programs. FY 1985 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

NASA automatic system for computer program documentation, volume 2

NASA Technical Reports Server (NTRS)

Simmons, D. B.

1972-01-01

The DYNASOR 2 program is used for the dynamic nonlinear analysis of shells of revolution. The equations of motion of the shell are solved using Houbolt's numerical procedure. The displacements and stress resultants are determined for both symmetrical and asymmetrical loading conditions. Asymmetrical dynamic buckling can be investigated. Solutions can be obtained for highly nonlinear problems utilizing as many as five of the harmonics generated by SAMMSOR program. A restart capability allows the user to restart the program at a specified time. For Vol. 1, see N73-22129.

The Solar Dynamics Observatory Education and Public Outreach Program: The First Years

NASA Astrophysics Data System (ADS)

Wawro, M.; Drobnes, E.; van Doren, A.; Scherrer, D. K.

2010-12-01

The Solar Dynamics Observatory (SDO) Education and Public Outreach (E/PO) program began as a series of discrete programs implemented by each of the instrument teams and has evolved into a well-rounded program with a full suite of national and international programs: student, teacher, and journalist workshops, international research programs, family programs, etc. In this presentation, we provide an overview of our philosophy and approach and of some of the programs developed and implemented prior to launch. In conclusion we will summarize our successes, our failures, our lessons learned, and present guiding principles in the hope that future missions will use our platform as a guide to build upon for future programs, incorporating their own content to enhance the public's appreciation of the science that NASA does and its benefit to society.

Two stage gear tooth dynamics program

NASA Technical Reports Server (NTRS)

Boyd, Linda S.

1989-01-01

The epicyclic gear dynamics program was expanded to add the option of evaluating the tooth pair dynamics for two epicyclic gear stages with peripheral components. This was a practical extension to the program as multiple gear stages are often used for speed reduction, space, weight, and/or auxiliary units. The option was developed for either stage to be a basic planetary, star, single external-external mesh, or single external-internal mesh. The two stage system allows for modeling of the peripherals with an input mass and shaft, an output mass and shaft, and a connecting shaft. Execution of the initial test case indicated an instability in the solution with the tooth paid loads growing to excessive magnitudes. A procedure to trace the instability is recommended as well as a method of reducing the program's computation time by reducing the number of boundary condition iterations.

DYNSYL: a general-purpose dynamic simulator for chemical processes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patterson, G.K.; Rozsa, R.B.

1978-09-05

Lawrence Livermore Laboratory is conducting a safeguards program for the Nuclear Regulatory Commission. The goal of the Material Control Project of this program is to evaluate material control and accounting (MCA) methods in plants that handle special nuclear material (SNM). To this end we designed and implemented the dynamic chemical plant simulation program DYNSYL. This program can be used to generate process data or to provide estimates of process performance; it simulates both steady-state and dynamic behavior. The MCA methods that may have to be evaluated range from sophisticated on-line material trackers such as Kalman filter estimators, to relatively simplemore » material balance procedures. This report describes the overall structure of DYNSYL and includes some example problems. The code is still in the experimental stage and revision is continuing.« less

Coupled rotor/airframe vibration analysis program manual manual. Volume 1: User's and programmer's instructions

NASA Technical Reports Server (NTRS)

Cassarino, S.; Sopher, R.

1982-01-01

user instruction and software descriptions for the base program of the coupled rotor/airframe vibration analysis are provided. The functional capabilities and procedures for running the program are provided. Interfaces with external programs are discussed. The procedure of synthesizing a dynamic system and the various solution methods are described. Input data and output results are presented. Detailed information is provided on the program structure. Sample test case results for five representative dynamic configurations are provided and discussed. System response are plotted to demonstrate the plots capabilities available. Instructions to install and execute SIMVIB on the CDC computer system are provided.

Program of Research in Flight Dynamics, The George Washington University at NASA Langley Research Center

NASA Technical Reports Server (NTRS)

Murphy, Patrick C. (Technical Monitor); Klein, Vladislav

2005-01-01

The program objectives are fully defined in the original proposal entitled Program of Research in Flight Dynamics in GW at NASA Langley Research Center, which was originated March 20, 1975, and in the renewals of the research program from January 1, 2003 to September 30, 2005. The program in its present form includes three major topics: 1. the improvement of existing methods and development of new methods for wind tunnel and flight data analysis, 2. the application of these methods to wind tunnel and flight test data obtained from advanced airplanes, 3. the correlation of flight results with wind tunnel measurements, and theoretical predictions.

Correlation of finite-element structural dynamic analysis with measured free vibration characteristics for a full-scale helicopter fuselage

NASA Technical Reports Server (NTRS)

Kenigsberg, I. J.; Dean, M. W.; Malatino, R.

1974-01-01

The correlation achieved with each program provides the material for a discussion of modeling techniques developed for general application to finite-element dynamic analyses of helicopter airframes. Included are the selection of static and dynamic degrees of freedom, cockpit structural modeling, and the extent of flexible-frame modeling in the transmission support region and in the vicinity of large cut-outs. The sensitivity of predicted results to these modeling assumptions are discussed. Both the Sikorsky Finite-Element Airframe Vibration analysis Program (FRAN/Vibration Analysis) and the NASA Structural Analysis Program (NASTRAN) have been correlated with data taken in full-scale vibration tests of a modified CH-53A helicopter.

i-PI: A Python interface for ab initio path integral molecular dynamics simulations

NASA Astrophysics Data System (ADS)

Ceriotti, Michele; More, Joshua; Manolopoulos, David E.

2014-03-01

Recent developments in path integral methodology have significantly reduced the computational expense of including quantum mechanical effects in the nuclear motion in ab initio molecular dynamics simulations. However, the implementation of these developments requires a considerable programming effort, which has hindered their adoption. Here we describe i-PI, an interface written in Python that has been designed to minimise the effort required to bring state-of-the-art path integral techniques to an electronic structure program. While it is best suited to first principles calculations and path integral molecular dynamics, i-PI can also be used to perform classical molecular dynamics simulations, and can just as easily be interfaced with an empirical forcefield code. To give just one example of the many potential applications of the interface, we use it in conjunction with the CP2K electronic structure package to showcase the importance of nuclear quantum effects in high-pressure water. Catalogue identifier: AERN_v1_0 Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AERN_v1_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: GNU General Public License, version 3 No. of lines in distributed program, including test data, etc.: 138626 No. of bytes in distributed program, including test data, etc.: 3128618 Distribution format: tar.gz Programming language: Python. Computer: Multiple architectures. Operating system: Linux, Mac OSX, Windows. RAM: Less than 256 Mb Classification: 7.7. External routines: NumPy Nature of problem: Bringing the latest developments in the modelling of nuclear quantum effects with path integral molecular dynamics to ab initio electronic structure programs with minimal implementational effort. Solution method: State-of-the-art path integral molecular dynamics techniques are implemented in a Python interface. Any electronic structure code can be patched to receive the atomic coordinates from the Python interface, and to return the forces and energy that are used to integrate the equations of motion. Restrictions: This code only deals with distinguishable particles. It does not include fermonic or bosonic exchanges between equivalent nuclei, which can become important at very low temperatures. Running time: Depends dramatically on the nature of the simulation being performed. A few minutes for short tests with empirical force fields, up to several weeks for production calculations with ab initio forces. The examples provided with the code run in less than an hour.

Method for resource control in parallel environments using program organization and run-time support

NASA Technical Reports Server (NTRS)

Ekanadham, Kattamuri (Inventor); Moreira, Jose Eduardo (Inventor); Naik, Vijay Krishnarao (Inventor)

2001-01-01

A system and method for dynamic scheduling and allocation of resources to parallel applications during the course of their execution. By establishing well-defined interactions between an executing job and the parallel system, the system and method support dynamic reconfiguration of processor partitions, dynamic distribution and redistribution of data, communication among cooperating applications, and various other monitoring actions. The interactions occur only at specific points in the execution of the program where the aforementioned operations can be performed efficiently.

Method for resource control in parallel environments using program organization and run-time support

NASA Technical Reports Server (NTRS)

Ekanadham, Kattamuri (Inventor); Moreira, Jose Eduardo (Inventor); Naik, Vijay Krishnarao (Inventor)

1999-01-01

A system and method for dynamic scheduling and allocation of resources to parallel applications during the course of their execution. By establishing well-defined interactions between an executing job and the parallel system, the system and method support dynamic reconfiguration of processor partitions, dynamic distribution and redistribution of data, communication among cooperating applications, and various other monitoring actions. The interactions occur only at specific points in the execution of the program where the aforementioned operations can be performed efficiently.

Experimental dynamic response of a two-dimensional, Mach 2.7, mixed compression inlet

NASA Technical Reports Server (NTRS)

Baumbick, R. J.; Neiner, G. H.; Cole, G. L.

1972-01-01

A test program was conducted on a two-dimensional supersonic inlet. Internal disturbances in diffuser exit mass flow were produced by oscillating overboard bypass doors. Open-loop dynamic responses of shock position, throat exit and diffuser exit static pressures are presented. The steady-state and dynamic coupling between ducts were also obtained. The experimental results from the two-dimensional inlet are compared to results from a similar size axisymmetric inlet and also to a transfer function synthesis program.

77 FR 44684 - General Dynamics Itronix Corporation; A Subsidiary of General Dynamics Corporation, Including...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

... program management services for rugged laptop computers and rugged mobile devices. The worker group... of program management services for rugged laptop computers and rugged mobile devices, meet the worker... threatened to become totally or partially separated. Section 222(a)(2)(A)(i) has been met because the sales...

Analysis of structural dynamic data from Skylab. Volume 1: Technical discussion

NASA Technical Reports Server (NTRS)

Demchak, L.; Harcrow, H.

1976-01-01

The results of a study to analyze data and document dynamic program highlights of the Skylab Program are presented. Included are structural model sources, illustration of the analytical models, utilization of models and the resultant derived data, data supplied to organization and subsequent utilization, and specifications of model cycles.

Analysis, modeling, and simulation (AMS) testbed development and evaluation to support dynamic mobility applications (DMA) and active transportation and demand management (ATDM) programs — evaluation summary for DMA program.

DOT National Transportation Integrated Search

2017-07-04

The primary objective of this project is to develop multiple simulation testbeds/transportation models to evaluate the impacts of Dynamic Mobility Application (DMA) connected vehicle applications and Active Transportation and Demand management (ATDM)...

Teachers' Scaffolding of Students' Learning of Geometry While Using a Dynamic Geometry Program

ERIC Educational Resources Information Center

Dove, Anthony; Hollenbrands, Karen

2014-01-01

This study examined the scaffolds that three high school mathematics teachers provided to their geometry students as they used technology to explore geometric ideas. Teachers often used structured activities using a dynamic geometry program and provided significant emotive feedback while students worked through the tasks. This provided…

Structures and Dynamics Division research and technology plans for FY 1988 and accomplishments for FY 1987

NASA Technical Reports Server (NTRS)

Bales, Kay S.

1988-01-01

Presented are the Objectives, FY 1988 Plans, Approach, and FY 1988 Milestones for the Structures and Dynamics Division (Langley Research Center) research programs. FY 1987 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

Analysis, modeling, and simulation (AMS) testbed development and evaluation to support dynamic mobility applications (DMA) and active transportation and demand management (ATDM) programs — evaluation report for ATDM program.

DOT National Transportation Integrated Search

2017-07-16

The primary objective of this project is to develop multiple simulation testbeds/transportation models to evaluate the impacts of Dynamic Mobility Applications (DMA) and the Active Transportation and Demand Management (ATDM) strategies. Specifically,...

Suggested Courseware for the Non-Calculus Physics Student: Projectile Motion, Circular Motion, Rotational Dynamics, and Statics.

ERIC Educational Resources Information Center

Mahoney, Joyce; And Others

1988-01-01

Evaluates 10 courseware packages covering topics for introductory physics. Discusses the price; sub-topics; program type; interaction; possible hardware; time; calculus required; graphics; and comments on each program. Recommends two packages in projectile and circular motion, and three packages in statics and rotational dynamics. (YP)

An Optimal Algorithm towards Successive Location Privacy in Sensor Networks with Dynamic Programming

NASA Astrophysics Data System (ADS)

Zhao, Baokang; Wang, Dan; Shao, Zili; Cao, Jiannong; Chan, Keith C. C.; Su, Jinshu

In wireless sensor networks, preserving location privacy under successive inference attacks is extremely critical. Although this problem is NP-complete in general cases, we propose a dynamic programming based algorithm and prove it is optimal in special cases where the correlation only exists between p immediate adjacent observations.

The Dynamic Geometrisation of Computer Programming

ERIC Educational Resources Information Center

Sinclair, Nathalie; Patterson, Margaret

2018-01-01

The goal of this paper is to explore dynamic geometry environments (DGE) as a type of computer programming language. Using projects created by secondary students in one particular DGE, we analyse the extent to which the various aspects of computational thinking--including both ways of doing things and particular concepts--were evident in their…

MassMutual Partners with EP for a Dynamic Double Play

ERIC Educational Resources Information Center

Exceptional Parent, 2008

2008-01-01

In 2002 "Exceptional Parent" (EP) magazine had a vision--a vision of a dynamic, community outreach program that would raise the public's awareness about the special needs community. This program, now known as Disability Awareness Night, or DAN, would enlighten the public by calling attention to the dedication, perseverance, and the extraordinary…

Analysis, modeling, and simulation (AMS) testbed development and evaluation to support dynamic mobility applications (DMA) and active transportation and demand management (ATDM) programs — evaluation report for DMA program.

DOT National Transportation Integrated Search

2017-02-02

The primary objective of this project is to develop multiple simulation testbeds/transportation models to evaluate the impacts of DMA connected vehicle applications and the active and dynamic transportation management (ATDM) strategies. The outputs (...

Heuristic Implementation of Dynamic Programming for Matrix Permutation Problems in Combinatorial Data Analysis

ERIC Educational Resources Information Center

Brusco, Michael J.; Kohn, Hans-Friedrich; Stahl, Stephanie

2008-01-01

Dynamic programming methods for matrix permutation problems in combinatorial data analysis can produce globally-optimal solutions for matrices up to size 30x30, but are computationally infeasible for larger matrices because of enormous computer memory requirements. Branch-and-bound methods also guarantee globally-optimal solutions, but computation…

Structures and Dynamics Division research and technology plans for FY 1987 and accomplishments for FY 1986

NASA Technical Reports Server (NTRS)

Bales, Kay S.

1987-01-01

This paper presents the Objectives, FY 1987 Plans, Approach, and FY 1987 Milestones for the Structures and Dynamics Division's research programs. FY 1986 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

Structures and Dynamics Division research and technology plans for FY 1985 and accomplishments for FY 1984

NASA Technical Reports Server (NTRS)

Bales, K. S.

1985-01-01

The objectives, FY 1985 plans, approach, and FY 1985 milestones for the Structures and Dynamics Division's research programs are presented. The FY 1984 accomplishments are presented where applicable. This information is useful in program coordination with other government organizations in areas of mutual interest.

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program.

PubMed

Khacho, Mireille; Clark, Alysen; Svoboda, Devon S; Azzi, Joelle; MacLaurin, Jason G; Meghaizel, Cynthia; Sesaki, Hiromi; Lagace, Diane C; Germain, Marc; Harper, Mary-Ellen; Park, David S; Slack, Ruth S

2016-08-04

Regulated mechanisms of stem cell maintenance are key to preventing stem cell depletion and aging. While mitochondrial morphology plays a fundamental role in tissue development and homeostasis, its role in stem cells remains unknown. Here, we uncover that mitochondrial dynamics regulates stem cell identity, self-renewal, and fate decisions by orchestrating a transcriptional program. Manipulation of mitochondrial structure, through OPA1 or MFN1/2 deletion, impaired neural stem cell (NSC) self-renewal, with consequent age-dependent depletion, neurogenesis defects, and cognitive impairments. Gene expression profiling revealed ectopic expression of the Notch self-renewal inhibitor Botch and premature induction of transcription factors that promote differentiation. Changes in mitochondrial dynamics regulate stem cell fate decisions by driving a physiological reactive oxygen species (ROS)-mediated process, which triggers a dual program to suppress self-renewal and promote differentiation via NRF2-mediated retrograde signaling. These findings reveal mitochondrial dynamics as an upstream regulator of essential mechanisms governing stem cell self-renewal and fate decisions through transcriptional programming. Copyright © 2016 Elsevier Inc. All rights reserved.

Application of dynamic programming to control khuzestan water resources system

USGS Publications Warehouse

Jamshidi, M.; Heidari, M.

1977-01-01

An approximate optimization technique based on discrete dynamic programming called discrete differential dynamic programming (DDDP), is employed to obtain the near optimal operation policies of a water resources system in the Khuzestan Province of Iran. The technique makes use of an initial nominal state trajectory for each state variable, and forms corridors around the trajectories. These corridors represent a set of subdomains of the entire feasible domain. Starting with such a set of nominal state trajectories, improvements in objective function are sought within the corridors formed around them. This leads to a set of new nominal trajectories upon which more improvements may be sought. Since optimization is confined to a set of subdomains, considerable savings in memory and computer time are achieved over that of conventional dynamic programming. The Kuzestan water resources system considered in this study is located in southwest Iran, and consists of two rivers, three reservoirs, three hydropower plants, and three irrigable areas. Data and cost benefit functions for the analysis were obtained either from the historical records or from similar studies. ?? 1977.

Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming.

PubMed

Zhao, Ting; Fu, Yao; Zhu, Jialiang; Liu, Yifang; Zhang, Qian; Yi, Zexuan; Chen, Shi; Jiao, Zhonggang; Xu, Xiaochan; Xu, Junquan; Duo, Shuguang; Bai, Yun; Tang, Chao; Li, Cheng; Deng, Hongkui

2018-06-12

Chemical reprogramming provides a powerful platform for exploring the molecular dynamics that lead to pluripotency. Although previous studies have uncovered an intermediate extraembryonic endoderm (XEN)-like state during this process, the molecular underpinnings of pluripotency acquisition remain largely undefined. Here, we profile 36,199 single-cell transcriptomes at multiple time points throughout a highly efficient chemical reprogramming system using RNA-sequencing and reconstruct their progression trajectories. Through identifying sequential molecular events, we reveal that the dynamic early embryonic-like programs are key aspects of successful reprogramming from XEN-like state to pluripotency, including the concomitant transcriptomic signatures of two-cell (2C) embryonic-like and early pluripotency programs and the epigenetic signature of notable genome-wide DNA demethylation. Moreover, via enhancing the 2C-like program by fine-tuning chemical treatment, the reprogramming process is remarkably accelerated. Collectively, our findings offer a high-resolution dissection of cell fate dynamics during chemical reprogramming and shed light on mechanistic insights into the nature of induced pluripotency. Copyright © 2018 Elsevier Inc. All rights reserved.

Joint Chance-Constrained Dynamic Programming

NASA Technical Reports Server (NTRS)

Ono, Masahiro; Kuwata, Yoshiaki; Balaram, J. Bob

2012-01-01

This paper presents a novel dynamic programming algorithm with a joint chance constraint, which explicitly bounds the risk of failure in order to maintain the state within a specified feasible region. A joint chance constraint cannot be handled by existing constrained dynamic programming approaches since their application is limited to constraints in the same form as the cost function, that is, an expectation over a sum of one-stage costs. We overcome this challenge by reformulating the joint chance constraint into a constraint on an expectation over a sum of indicator functions, which can be incorporated into the cost function by dualizing the optimization problem. As a result, the primal variables can be optimized by a standard dynamic programming, while the dual variable is optimized by a root-finding algorithm that converges exponentially. Error bounds on the primal and dual objective values are rigorously derived. We demonstrate the algorithm on a path planning problem, as well as an optimal control problem for Mars entry, descent and landing. The simulations are conducted using a real terrain data of Mars, with four million discrete states at each time step.

Algorithms and software for nonlinear structural dynamics

NASA Technical Reports Server (NTRS)

Belytschko, Ted; Gilbertsen, Noreen D.; Neal, Mark O.

1989-01-01

The objective of this research is to develop efficient methods for explicit time integration in nonlinear structural dynamics for computers which utilize both concurrency and vectorization. As a framework for these studies, the program WHAMS, which is described in Explicit Algorithms for the Nonlinear Dynamics of Shells (T. Belytschko, J. I. Lin, and C.-S. Tsay, Computer Methods in Applied Mechanics and Engineering, Vol. 42, 1984, pp 225 to 251), is used. There are two factors which make the development of efficient concurrent explicit time integration programs a challenge in a structural dynamics program: (1) the need for a variety of element types, which complicates the scheduling-allocation problem; and (2) the need for different time steps in different parts of the mesh, which is here called mixed delta t integration, so that a few stiff elements do not reduce the time steps throughout the mesh.

Adaptive Event-Triggered Control Based on Heuristic Dynamic Programming for Nonlinear Discrete-Time Systems.

PubMed

Dong, Lu; Zhong, Xiangnan; Sun, Changyin; He, Haibo

2017-07-01

This paper presents the design of a novel adaptive event-triggered control method based on the heuristic dynamic programming (HDP) technique for nonlinear discrete-time systems with unknown system dynamics. In the proposed method, the control law is only updated when the event-triggered condition is violated. Compared with the periodic updates in the traditional adaptive dynamic programming (ADP) control, the proposed method can reduce the computation and transmission cost. An actor-critic framework is used to learn the optimal event-triggered control law and the value function. Furthermore, a model network is designed to estimate the system state vector. The main contribution of this paper is to design a new trigger threshold for discrete-time systems. A detailed Lyapunov stability analysis shows that our proposed event-triggered controller can asymptotically stabilize the discrete-time systems. Finally, we test our method on two different discrete-time systems, and the simulation results are included.

Engineering evaluation of SSME dynamic data from engine tests and SSV flights

NASA Technical Reports Server (NTRS)

1986-01-01

An engineering evaluation of dynamic data from SSME hot firing tests and SSV flights is summarized. The basic objective of the study is to provide analyses of vibration, strain and dynamic pressure measurements in support of MSFC performance and reliability improvement programs. A brief description of the SSME test program is given and a typical test evaluation cycle reviewed. Data banks generated to characterize SSME component dynamic characteristics are described and statistical analyses performed on these data base measurements are discussed. Analytical models applied to define the dynamic behavior of SSME components (such as turbopump bearing elements and the flight accelerometer safety cut-off system) are also summarized. Appendices are included to illustrate some typical tasks performed under this study.

Dynamics of the McDonnell Douglas Large Scale Dynamic Rig and Dynamic Calibration of the Rotor Balance

DOT National Transportation Integrated Search

1994-10-01

A shake test was performed on the Large Scale Dynamic Rig in the 40- by 80-Foot Wind Tunnel in support of the McDonnell Douglas Advanced Rotor Technology (MDART) Test Program. The shake test identifies the hub modes and the dynamic calibration matrix...

MPI implementation of PHOENICS: A general purpose computational fluid dynamics code

NASA Astrophysics Data System (ADS)

Simunovic, S.; Zacharia, T.; Baltas, N.; Spalding, D. B.

1995-03-01

PHOENICS is a suite of computational analysis programs that are used for simulation of fluid flow, heat transfer, and dynamical reaction processes. The parallel version of the solver EARTH for the Computational Fluid Dynamics (CFD) program PHOENICS has been implemented using Message Passing Interface (MPI) standard. Implementation of MPI version of PHOENICS makes this computational tool portable to a wide range of parallel machines and enables the use of high performance computing for large scale computational simulations. MPI libraries are available on several parallel architectures making the program usable across different architectures as well as on heterogeneous computer networks. The Intel Paragon NX and MPI versions of the program have been developed and tested on massively parallel supercomputers Intel Paragon XP/S 5, XP/S 35, and Kendall Square Research, and on the multiprocessor SGI Onyx computer at Oak Ridge National Laboratory. The preliminary testing results of the developed program have shown scalable performance for reasonably sized computational domains.

MPI implementation of PHOENICS: A general purpose computational fluid dynamics code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simunovic, S.; Zacharia, T.; Baltas, N.

1995-04-01

PHOENICS is a suite of computational analysis programs that are used for simulation of fluid flow, heat transfer, and dynamical reaction processes. The parallel version of the solver EARTH for the Computational Fluid Dynamics (CFD) program PHOENICS has been implemented using Message Passing Interface (MPI) standard. Implementation of MPI version of PHOENICS makes this computational tool portable to a wide range of parallel machines and enables the use of high performance computing for large scale computational simulations. MPI libraries are available on several parallel architectures making the program usable across different architectures as well as on heterogeneous computer networks. Themore » Intel Paragon NX and MPI versions of the program have been developed and tested on massively parallel supercomputers Intel Paragon XP/S 5, XP/S 35, and Kendall Square Research, and on the multiprocessor SGI Onyx computer at Oak Ridge National Laboratory. The preliminary testing results of the developed program have shown scalable performance for reasonably sized computational domains.« less

Expansion of epicyclic gear dynamic analysis program

NASA Technical Reports Server (NTRS)

Boyd, Linda Smith; Pike, James A.

1987-01-01

The multiple mesh/single stage dynamics program is a gear tooth analysis program which determines detailed geometry, dynamic loads, stresses, and surface damage factors. The program can analyze a variety of both epicyclic and single mesh systems with spur or helical gear teeth including internal, external, and buttress tooth forms. The modifications refine the options for the flexible carrier and flexible ring gear rim and adds three options: a floating Sun gear option; a natural frequency option; and a finite element compliance formulation for helical gear teeth. The option for a floating Sun incorporates two additional degrees of freedom at the Sun center. The natural frequency option evaluates the frequencies of planetary, star, or differential systems as well as the effect of additional springs at the Sun center and those due to a flexible carrier and/or ring gear rim. The helical tooth pair finite element calculated compliance is obtained from an automated element breakup of the helical teeth and then is used with the basic gear dynamic solution and stress postprocessing routines. The flexible carrier or ring gear rim option for planetary and star spur gear systems allows the output torque per carrier and ring gear rim segment to vary based on the dynamic response of the entire system, while the total output torque remains constant.

Romantic Relationship Dynamics of Urban African American Adolescents: Patterns of Monogamy, Commitment, and Trust.

PubMed

Towner, Senna L; Dolcini, M Margaret; Harper, Gary W

2015-05-01

Relationship dynamics develop early in life and are influenced by social environments. STI/HIV prevention programs need to consider romantic relationship dynamics that contribute to sexual health. The aim of this study was to examine monogamous patterns, commitment, and trust in African American adolescent romantic relationships. The authors also focused on the differences in these dynamics between and within gender. The way that such dynamics interplay in romantic relationships has the potential to influence STI/HIV acquisition risk. In-depth interviews were conducted with 28 African American adolescents aged 14 to 21 living in San Francisco. Our results discuss data related to monogamous behaviors, expectations, and values; trust and respect in romantic relationships; commitment to romantic relationships; and outcomes of mismatched relationship expectations. Incorporating gender-specific romantic relationships dynamics can enhance the effectiveness of prevention programs.

Computer Program for Analysis, Design and Optimization of Propulsion, Dynamics, and Kinematics of Multistage Rockets

NASA Astrophysics Data System (ADS)

Lali, Mehdi

2009-03-01

A comprehensive computer program is designed in MATLAB to analyze, design and optimize the propulsion, dynamics, thermodynamics, and kinematics of any serial multi-staging rocket for a set of given data. The program is quite user-friendly. It comprises two main sections: "analysis and design" and "optimization." Each section has a GUI (Graphical User Interface) in which the rocket's data are entered by the user and by which the program is run. The first section analyzes the performance of the rocket that is previously devised by the user. Numerous plots and subplots are provided to display the performance of the rocket. The second section of the program finds the "optimum trajectory" via billions of iterations and computations which are done through sophisticated algorithms using numerical methods and incremental integrations. Innovative techniques are applied to calculate the optimal parameters for the engine and designing the "optimal pitch program." This computer program is stand-alone in such a way that it calculates almost every design parameter in regards to rocket propulsion and dynamics. It is meant to be used for actual launch operations as well as educational and research purposes.

Dynamic gas temperature measurement system. Volume 2: Operation and program manual

NASA Technical Reports Server (NTRS)

Purpura, P. T.

1983-01-01

The hot section technology (HOST) dynamic gas temperature measurement system computer program acquires data from two type B thermocouples of different diameters. The analysis method determines the in situ value of an aerodynamic parameter T, containing the heat transfer coefficient from the transfer function of the two thermocouples. This aerodynamic parameter is used to compute a fequency response spectrum and compensate the dynamic portion of the signal of the smaller thermocouple. The calculations for the aerodynamic parameter and the data compensation technique are discussed. Compensated data are presented in either the time or frequency domain, time domain data as dynamic temperature vs time, or frequency domain data.

Integrating multiple data sources for malware classification

DOEpatents

Anderson, Blake Harrell; Storlie, Curtis B; Lane, Terran

2015-04-28

Disclosed herein are representative embodiments of tools and techniques for classifying programs. According to one exemplary technique, at least one graph representation of at least one dynamic data source of at least one program is generated. Also, at least one graph representation of at least one static data source of the at least one program is generated. Additionally, at least using the at least one graph representation of the at least one dynamic data source and the at least one graph representation of the at least one static data source, the at least one program is classified.

How Formal Dynamic Verification Tools Facilitate Novel Concurrency Visualizations

NASA Astrophysics Data System (ADS)

Aananthakrishnan, Sriram; Delisi, Michael; Vakkalanka, Sarvani; Vo, Anh; Gopalakrishnan, Ganesh; Kirby, Robert M.; Thakur, Rajeev

With the exploding scale of concurrency, presenting valuable pieces of information collected by formal verification tools intuitively and graphically can greatly enhance concurrent system debugging. Traditional MPI program debuggers present trace views of MPI program executions. Such views are redundant, often containing equivalent traces that permute independent MPI calls. In our ISP formal dynamic verifier for MPI programs, we present a collection of alternate views made possible by the use of formal dynamic verification. Some of ISP’s views help pinpoint errors, some facilitate discerning errors by eliminating redundancy, while others help understand the program better by displaying concurrent even orderings that must be respected by all MPI implementations, in the form of completes-before graphs. In this paper, we describe ISP’s graphical user interface (GUI) capabilities in all these areas which are currently supported by a portable Java based GUI, a Microsoft Visual Studio GUI, and an Eclipse based GUI whose development is in progress.

Research program of the Geodynamics Branch

NASA Technical Reports Server (NTRS)

Kahn, W. D. (Editor); Cohen, S. C. (Editor); Boccucci, B. S. (Editor)

1986-01-01

This report is the Fourth Annual Summary of the Research Program of the Geodynamics Branch. The branch is located within the Laboratory for Terrestrial Physics of the Space and Earth Sciences Directorate of the Goddard Space Flight Center. The research activities of the branch staff cover a broad spectrum of geoscience disciplines including: tectonophysics, space geodesy, geopotential field modeling, and dynamic oceanography. The NASA programs which are supported by the work described in this document include the Geodynamics and Ocean Programs, the Crustal Dynamics Project and the proposed Ocean Topography Experiment (TOPEX). The reports highlight the investigations conducted by the Geodynamics Branch staff during calendar year 1985. The individual papers are grouped into chapters on Crustal Movements and Solid Earth Dynamics, Gravity Field Modeling and Sensing Techniques, and Sea Surface Topography. Further information on the activities of the branch or the particular research efforts described herein can be obtained through the branch office or from individual staff members.

NACA0012 benchmark model experimental flutter results with unsteady pressure distributions

NASA Technical Reports Server (NTRS)

Rivera, Jose A., Jr.; Dansberry, Bryan E.; Bennett, Robert M.; Durham, Michael H.; Silva, Walter A.

1992-01-01

The Structural Dynamics Division at NASA Langley Research Center has started a wind tunnel activity referred to as the Benchmark Models Program. The primary objective of this program is to acquire measured dynamic instability and corresponding pressure data that will be useful for developing and evaluating aeroelastic type computational fluid dynamics codes currently in use or under development. The program is a multi-year activity that will involve testing of several different models to investigate various aeroelastic phenomena. This paper describes results obtained from a second wind tunnel test of the first model in the Benchmark Models Program. This first model consisted of a rigid semispan wing having a rectangular planform and a NACA 0012 airfoil shape which was mounted on a flexible two degree of freedom mount system. Experimental flutter boundaries and corresponding unsteady pressure distribution data acquired over two model chords located at the 60 and 95 percent span stations are presented.

Effects of a resistance training program on balance and fatigue perception in patients with Parkinson's disease: A randomized controlled trial.

PubMed

Ortiz-Rubio, Araceli; Cabrera-Martos, Irene; Torres-Sánchez, Irene; Casilda-López, Jesús; López-López, Laura; Valenza, Marie Carmen

2017-11-22

Fatigue and balance impairment leads to a loss of independence and are important to adequately manage. The objective of this study was to examine the effects of a resistance training program on dynamic balance and fatigue in patients with Parkinson's disease (PD). Randomized controlled trial. Forty-six patients with PD were randomly allocated to an intervention group receiving a 8-week resistance training program focused on lower limbs or to a control group. Balance was assessed using the Mini-BESTest and fatigue was assessed by the Piper Fatigue Scale. Patients in the intervention group improved significantly (p<0.05) on dynamic balance (reactive postural control and total values) and perceived fatigue. An 8-week resistance training program was found to be effective at improving dynamic balance and fatigue in patients with PD. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

Dynamic Mobility Applications Policy Analysis: Policy and Institutional Issues for Integrated Dynamic Transit Operations (IDTO). [supporting datasets

DOT National Transportation Integrated Search

2015-01-27

The datasets in this zip file are in support of Intelligent Transportation Systems Joint Program Office (ITS JPO) report FHWA-JPO-14-134, "Dynamic Mobility Applications Policy Analysis: Policy and Institutional Issues for Integrated Dynamic Transit O...

Solution Methods for Stochastic Dynamic Linear Programs.

DTIC Science & Technology

1980-12-01

16, No. 11, pp. 652-675, July 1970. [28] Glassey, C.R., "Dynamic linear programs for production scheduling", OR 19, pp. 45-56. 1971 . 129 Glassey, C.R...Huang, C.C., I. Vertinsky, W.T. Ziemba, ’Sharp bounds on the value of perfect information", OR 25, pp. 128-139, 1977. [37 Kall , P., ’Computational... 1971 . [701 Ziemba, W.T., *Computational algorithms for convex stochastic programs with simple recourse", OR 8, pp. 414-431, 1970. 131 UNCLASSI FIED

Overview of the solar dynamic ground test demonstration program

NASA Technical Reports Server (NTRS)

Shaltens, Richard K.; Boyle, Robert V.

1993-01-01

The Solar Dynamic (SD) Ground Test Demonstration (GTD) program demonstrates the availability of SD technologies in a simulated space environment at the NASA Lewis Research Center (LeRC) vacuum facility. An aerospace industry/ government team is working together to design, fabricate, build, and test a complete SD system. This paper reviews the goals and status of the SD GTD program. A description of the SD system includes key design features of the system, subsystems, and components as reported at the Critical Design Review (CDR).

Brayton advanced heat receiver development program

NASA Technical Reports Server (NTRS)

Heidenreich, G. R.; Downing, R. S.; Lacey, Dovie E.

1989-01-01

NASA Lewis Research Center is managing an advanced solar dynamic (ASD) space power program. The objective of the ASD program is to develop small and lightweight solar dynamic systems which show significant improvement in efficiency and specific mass over the baseline design derived from the Space Station Freedom technology. The advanced heat receiver development program is a phased program to design, fabricate and test elements of a 7-kWe heat-receiver/thermal-energy-storage subsystem. Receivers for both Brayton and Stirling heat engines are being developed under separate contracts. Phase I, described here, is the current eighteen month effort to design and perform critical technology experiments on innovative concepts designed to reduce mass without compromising thermal efficiency and reliability.

Dynamic trunk stabilization: a conceptual back injury prevention program for volleyball athletes.

PubMed

Smith, Chad E; Nyland, John; Caudill, Paul; Brosky, Joseph; Caborn, David N M

2008-11-01

The sport of volleyball creates considerable dynamic trunk stability demands. Back injury occurs all too frequently in volleyball, particularly among female athletes. The purpose of this clinical commentary is to review functional anatomy, muscle coactivation strategies, assessment of trunk muscle performance, and the characteristics of effective exercises for the trunk or core. From this information, a conceptual progressive 3-phase volleyball-specific training program is presented to improve dynamic trunk stability and to potentially reduce the incidence of back injury among volleyball athletes. Phase 1 addresses low-velocity motor control, kinesthetic awareness, and endurance, with the clinician providing cues to teach achievement of biomechanically neutral spine alignment. Phase 2 focuses on progressively higher velocity dynamic multiplanar endurance, coordination, and strength-power challenges integrating upper and lower extremity movements, while maintaining neutral spine alignment. Phase 3 integrates volleyball-specific skill simulations by breaking down composite movement patterns into their component parts, with differing dynamic trunk stability requirements, while maintaining neutral spine alignment. Prospective research is needed to validate the efficacy of this program.

Ckmeans.1d.dp: Optimal k-means Clustering in One Dimension by Dynamic Programming.

PubMed

Wang, Haizhou; Song, Mingzhou

2011-12-01

The heuristic k -means algorithm, widely used for cluster analysis, does not guarantee optimality. We developed a dynamic programming algorithm for optimal one-dimensional clustering. The algorithm is implemented as an R package called Ckmeans.1d.dp . We demonstrate its advantage in optimality and runtime over the standard iterative k -means algorithm.

Solving mixed integer nonlinear programming problems using spiral dynamics optimization algorithm

NASA Astrophysics Data System (ADS)

Kania, Adhe; Sidarto, Kuntjoro Adji

2016-02-01

Many engineering and practical problem can be modeled by mixed integer nonlinear programming. This paper proposes to solve the problem with modified spiral dynamics inspired optimization method of Tamura and Yasuda. Four test cases have been examined, including problem in engineering and sport. This method succeeds in obtaining the optimal result in all test cases.

A Constraint Embedding Approach for Complex Vehicle Suspension Dynamics

DTIC Science & Technology

2015-04-24

Complex Vehicle Suspension Dynamics ECCOMAS Thematic Conference on Multibody Dynamics 2015 Abhinandan Jain∗, Calvin Kuo#, Paramsothy Jayakumar †, Jonathan...Suspension Dynamics ECCOMAS Thematic Conference on Multibody Dynamics 2015 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...13. SUPPLEMENTARY NOTES ECCOMAS Thematic Conference on Multibody Dynamics 2015, June 29-July 2, 2015, Barcelona, Catalonia, Spain 14. ABSTRACT See

Space truss zero gravity dynamics

NASA Technical Reports Server (NTRS)

Swanson, Andy

1989-01-01

The Structural Dynamics Branch of the Air Force Flight Dynamics Laboratory in cooperation with the Reduced Gravity Office of the NASA Lyndon B. Johnson Space Center (JSC) plans to perform zero-gravity dynamic tests of a 12-meter truss structure. This presentation describes the program and presents all results obtained to date.

Space station dynamics, attitude control and momentum management

NASA Technical Reports Server (NTRS)

Sunkel, John W.; Singh, Ramen P.; Vengopal, Ravi

1989-01-01

The Space Station Attitude Control System software test-bed provides a rigorous environment for the design, development and functional verification of GN and C algorithms and software. The approach taken for the simulation of the vehicle dynamics and environmental models using a computationally efficient algorithm is discussed. The simulation includes capabilities for docking/berthing dynamics, prescribed motion dynamics associated with the Mobile Remote Manipulator System (MRMS) and microgravity disturbances. The vehicle dynamics module interfaces with the test-bed through the central Communicator facility which is in turn driven by the Station Control Simulator (SCS) Executive. The Communicator addresses issues such as the interface between the discrete flight software and the continuous vehicle dynamics, and multi-programming aspects such as the complex flow of control in real-time programs. Combined with the flight software and redundancy management modules, the facility provides a flexible, user-oriented simulation platform.

ONR Ocean Wave Dynamics Workshop

NASA Astrophysics Data System (ADS)

In anticipation of the start (in Fiscal Year 1988) of a new Office of Naval Research (ONR) Accelerated Research Initiative (ARI) on Ocean Surface Wave Dynamics, a workshop was held August 5-7, 1986, at Woods Hole, Mass., to discuss new ideas and directions of research. This new ARI on Ocean Surface Wave Dynamics is a 5-year effort that is organized by the ONR Physical Oceanography Program in cooperation with the ONR Fluid Mechanics Program and the Physical Oceanography Branch at the Naval Ocean Research and Development Activity (NORDA). The central theme is improvement of our understanding of the basic physics and dynamics of surface wave phenomena, with emphasis on the following areas: precise air-sea coupling mechanisms,dynamics of nonlinear wave-wave interaction under realistic environmental conditions,wave breaking and dissipation of energy,interaction between surface waves and upper ocean boundary layer dynamics, andsurface statistical and boundary layer coherent structures.

Romantic Relationship Dynamics of Urban African American Adolescents: Patterns of Monogamy, Commitment, and Trust

PubMed Central

Towner, Senna L.; Dolcini, M. Margaret; Harper, Gary W.

2013-01-01

Relationship dynamics develop early in life and are influenced by social environments. STI/HIV prevention programs need to consider romantic relationship dynamics that contribute to sexual health. The aim of this study was to examine monogamous patterns, commitment, and trust in African American adolescent romantic relationships. The authors also focused on the differences in these dynamics between and within gender. The way that such dynamics interplay in romantic relationships has the potential to influence STI/HIV acquisition risk. In-depth interviews were conducted with 28 African American adolescents aged 14 to 21 living in San Francisco. Our results discuss data related to monogamous behaviors, expectations, and values; trust and respect in romantic relationships; commitment to romantic relationships; and outcomes of mismatched relationship expectations. Incorporating gender-specific romantic relationships dynamics can enhance the effectiveness of prevention programs. PMID:26691404

Determination of the plasma impedance of a glow discharge in carbon dioxide

NASA Astrophysics Data System (ADS)

Kiselev, A. S.; Smirnov, E. A.

2017-07-01

In this work an expression for the dynamic resistance of a glow discharge flowing in long tubes is obtained and analyzed. The expression describes the physical processes occurring in the positive column of a glow discharge. The frequency dependences of the active and reactive components as well as the dynamic resistance module for the discharge conditions corresponding to CO2-lasers have been calculated. Based on the simulation results developed a computer program in the C# programming language for modeling the dynamic resistance discharge of glow discharge lasers.

Dynamic Programming for Structured Continuous Markov Decision Problems

NASA Technical Reports Server (NTRS)

Dearden, Richard; Meuleau, Nicholas; Washington, Richard; Feng, Zhengzhu

2004-01-01

We describe an approach for exploiting structure in Markov Decision Processes with continuous state variables. At each step of the dynamic programming, the state space is dynamically partitioned into regions where the value function is the same throughout the region. We first describe the algorithm for piecewise constant representations. We then extend it to piecewise linear representations, using techniques from POMDPs to represent and reason about linear surfaces efficiently. We show that for complex, structured problems, our approach exploits the natural structure so that optimal solutions can be computed efficiently.

The READY program: Building a global potential energy surface and reactive dynamic simulations for the hydrogen combustion.

PubMed

Mogo, César; Brandão, João

2014-06-30

READY (REActive DYnamics) is a program for studying reactive dynamic systems using a global potential energy surface (PES) built from previously existing PESs corresponding to each of the most important elementary reactions present in the system. We present an application to the combustion dynamics of a mixture of hydrogen and oxygen using accurate PESs for all the systems involving up to four oxygen and hydrogen atoms. Results at the temperature of 4000 K and pressure of 2 atm are presented and compared with model based on rate constants. Drawbacks and advantages of this approach are discussed and future directions of research are pointed out. Copyright © 2014 Wiley Periodicals, Inc.

Supercomputer optimizations for stochastic optimal control applications

NASA Technical Reports Server (NTRS)

Chung, Siu-Leung; Hanson, Floyd B.; Xu, Huihuang

1991-01-01

Supercomputer optimizations for a computational method of solving stochastic, multibody, dynamic programming problems are presented. The computational method is valid for a general class of optimal control problems that are nonlinear, multibody dynamical systems, perturbed by general Markov noise in continuous time, i.e., nonsmooth Gaussian as well as jump Poisson random white noise. Optimization techniques for vector multiprocessors or vectorizing supercomputers include advanced data structures, loop restructuring, loop collapsing, blocking, and compiler directives. These advanced computing techniques and superconducting hardware help alleviate Bellman's curse of dimensionality in dynamic programming computations, by permitting the solution of large multibody problems. Possible applications include lumped flight dynamics models for uncertain environments, such as large scale and background random aerospace fluctuations.

Overview of the Solar Dynamic Ground Test Demonstration Program at the NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Shaltens, Richard K.

1995-01-01

The Solar Dynamic (SD) Ground Test Demonstration (GTD) program demonstrates the availability of SD technologies in a simulated space environment at the NASA Lewis Research Center (LERC) vacuum facility. Data from the SD GTD program will be provided to the joint U.S. and Russian team which is currently designing a 2 kW SD flight demonstration power system. This SD technology has the potential as a future power source for the International Space Station. This paper reviews the goals and status of the SD GTD program. A description of the SD GTD system includes key design features of the system, subsystems and components.

NERVA dynamic analysis methodology, SPRVIB

NASA Technical Reports Server (NTRS)

Vronay, D. F.

1972-01-01

The general dynamic computer code called SPRVIB (Spring Vib) developed in support of the NERVA (nuclear engine for rocket vehicle application) program is described. Using normal mode techniques, the program computes kinematical responses of a structure caused by various combinations of harmonic and elliptic forcing functions or base excitations. Provision is made for a graphical type of force or base excitation input to the structure. A description of the required input format and a listing of the program are presented, along with several examples illustrating the use of the program. SPRVIB is written in FORTRAN 4 computer language for use on the CDC 6600 or the IBM 360/75 computers.

Dynamic Docking Test System (DDTS) active table computer program NASA Advanced Docking System (NADS)

NASA Technical Reports Server (NTRS)

Gates, R. M.; Jantz, R. E.

1974-01-01

A computer program was developed to describe the three-dimensional motion of the Dynamic Docking Test System active table. The input consists of inertia and geometry data, actuator structural data, forcing function data, hydraulics data, servo electronics data, and integration control data. The output consists of table responses, actuator bending responses, and actuator responses.

Analysis, Modeling, and Simulation (AMS) Testbed Development and Evaluation to Support Dynamic Mobility Applications (DMA) and Active Transportation and Demand Management (ATDM) Programs - calibration Report for Phoenix Testbed : Final Report. [supporting datasets - Phoenix Testbed

DOT National Transportation Integrated Search

2017-07-26

The datasets in this zip file are in support of FHWA-JPO-16-379, Analysis, Modeling, and Simulation (AMS) Testbed Development and Evaluation to Support Dynamic Mobility Applications (DMA) and Active Transportation and Demand Management (ATDM) Program...

Analysis, modeling, and simulation (AMS) testbed development and evaluation to support dynamic mobility applications (DMA) and active transportation and demand management (ATDM) programs — summary report for the Chicago testbed. [supporting datasets - Chicago Testbed

DOT National Transportation Integrated Search

2017-04-01

The datasets in this zip file are in support of Intelligent Transportation Systems Joint Program Office (ITS JPO) report FHWA-JPO-16-385, "Analysis, Modeling, and Simulation (AMS) Testbed Development and Evaluation to Support Dynamic Mobility Applica...

Analysis, modeling, and simulation (AMS) testbed development and evaluation to support dynamic mobility applications (DMA) and active transportation and demand management (ATDM) programs : Dallas testbed analysis plan. [supporting datasets - Dallas Testbed

DOT National Transportation Integrated Search

2017-07-26

The datasets in this zip file are in support of Intelligent Transportation Systems Joint Program Office (ITS JPO) report FHWA-JPO-16-385, "Analysis, Modeling, and Simulation (AMS) Testbed Development and Evaluation to Support Dynamic Mobility Applica...

The Effects of Exercise on the Firing Patterns of Single Motor Units.

ERIC Educational Resources Information Center

Cracraft, Joe D.

In this study, the training effects of static and dynamic exercise programs on the firing patterns of 450 single motor units (SMU) in the human tibialis anterior muscle were investigated. In a six week program, the static group (N=5) participated in daily high intensity, short duration, isometric exercises while the dynamic group (N=5)…

Dynamics of change in Alaska's boreal forests: resilience and vulnerability in response to climate warming

Treesearch

A. David McGuire; F.S. Chapin; R.W. Ruess

2010-01-01

Long-term research by the Bonanza Creek (BNZ) Long Term Ecological Research (LTER) program has documented natural patterns of interannual and successional variability of the boreal forest in interior Alaska against which we can detect changes in system behavior. Between 2004 and 2010 the BNZ LTER program focused on understanding the dynamics of change through studying...

Analysis, Modeling, and Simulation (AMS) Testbed Development and Evaluation to Support Dynamic Mobility Applications (DMA) and Active Transportation and Demand Management (ATDM) Programs - San Mateo Testbed Analysis Plan [supporting datasets - San Mateo Testbed

DOT National Transportation Integrated Search

2017-06-26

This zip file contains files of data to support FHWA-JPO-16-370, Analysis, Modeling, and Simulation (AMS) Testbed Development and Evaluation to Support Dynamic Mobility Applications (DMA) and Active Transportation and Demand Management (ATDM) Program...

Evaluation Program for Secondary Spacecraft Cells: Initial Evaluation Tests of General Electric Company 6.0 Ampere Hour Nickel Cadmium Spacecraft Cells for the Dynamic Explorer Satellite Program

NASA Technical Reports Server (NTRS)

Harkness, J. D.

1980-01-01

Evaluation tests of 10 nickel cadmium cells are described. Although pressures were greater than what normally was exhibited by General Electric cells in the past, it is recommended that these cells be placed on life test simulating the predicted Dynamic Explorer flight profiles.

Application of a Dynamic Programming Algorithm for Weapon Target Assignment

DTIC Science & Technology

2016-02-01

25] A . Turan , “Techniques for the Allocation of Resources Under Uncertainty,” Middle Eastern Technical University, Ankara, Turkey, 2012. [26] K...UNCLASSIFIED UNCLASSIFIED Application of a Dynamic Programming Algorithm for Weapon Target Assignment Lloyd Hammond Weapons and...optimisation techniques to support the decision making process. This report documents the methodology used to identify, develop and assess a

Dynamic programming for optimization of timber production and grazing in ponderosa pine

Treesearch

Kurt H. Riitters; J. Douglas Brodie; David W. Hann

1982-01-01

Dynamic programming procedures are presented for optimizing thinning and rotation of even-aged ponderosa pine by using the four descriptors: age, basal area, number of trees, and time since thinning. Because both timber yield and grazing yield are functions of stand density, the two outputs-forage and timber-can both be optimized. The soil expectation values for single...

SigniSite: Identification of residue-level genotype-phenotype correlations in protein multiple sequence alignments.

PubMed

Jessen, Leon Eyrich; Hoof, Ilka; Lund, Ole; Nielsen, Morten

2013-07-01

Identifying which mutation(s) within a given genotype is responsible for an observable phenotype is important in many aspects of molecular biology. Here, we present SigniSite, an online application for subgroup-free residue-level genotype-phenotype correlation. In contrast to similar methods, SigniSite does not require any pre-definition of subgroups or binary classification. Input is a set of protein sequences where each sequence has an associated real number, quantifying a given phenotype. SigniSite will then identify which amino acid residues are significantly associated with the data set phenotype. As output, SigniSite displays a sequence logo, depicting the strength of the phenotype association of each residue and a heat-map identifying 'hot' or 'cold' regions. SigniSite was benchmarked against SPEER, a state-of-the-art method for the prediction of specificity determining positions (SDP) using a set of human immunodeficiency virus protease-inhibitor genotype-phenotype data and corresponding resistance mutation scores from the Stanford University HIV Drug Resistance Database, and a data set of protein families with experimentally annotated SDPs. For both data sets, SigniSite was found to outperform SPEER. SigniSite is available at: http://www.cbs.dtu.dk/services/SigniSite/.

Multi-Aperture Shower Design for the Improvement of the Transverse Uniformity of MOCVD-Derived GdYBCO Films

PubMed Central

Zhao, Ruipeng; Liu, Qing; Xia, Yudong; Zhang, Fei; Lu, Yuming; Cai, Chuanbing; Tao, Bowan; Li, Yanrong

2017-01-01

A multi-aperture shower design is reported to improve the transverse uniformity of GdYBCO superconducting films on the template of sputtered-LaMnO3/epitaxial-MgO/IBAD-MgO/solution deposition planarization (SDP)-Y2O3-buffered Hastelloy tapes. The GdYBCO films were prepared by the metal organic chemical vapor deposition (MOCVD) process. The transverse uniformities of structure, morphology, thickness, and performance were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), step profiler, and the standard four-probe method using the criteria of 1 μV/cm, respectively. Through adopting the multi-aperture shower instead of the slit shower, measurement by step profiler revealed that the thickness difference between the middle and the edges based on the slit shower design was well eliminated. Characterization by SEM showed that a GdYBCO film with a smooth surface was successfully prepared. Moreover, the transport critical current density (Jc) of its middle and edge positions at 77 K and self-field were found to be over 5 MA/cm2 through adopting the micro-bridge four-probe method. PMID:28914793

The Use of Kosher Phenotyping for Mapping QTL Affecting Susceptibility to Bovine Respiratory Disease

PubMed Central

Eitam, Harel; Yishay, Moran; Schiavini, Fausta; Soller, Morris; Bagnato, Alessandro; Shabtay, Ariel

2016-01-01

Bovine respiratory disease (BRD) is the leading cause of morbidity and mortality in feedlot cattle, caused by multiple pathogens that become more virulent in response to stress. As clinical signs often go undetected and various preventive strategies failed, identification of genes affecting BRD is essential for selection for resistance. Selective DNA pooling (SDP) was applied in a genome wide association study (GWAS) to map BRD QTLs in Israeli Holstein male calves. Kosher scoring of lung adhesions was used to allocate 122 and 62 animals to High (Glatt Kosher) and Low (Non-Kosher) resistant groups, respectively. Genotyping was performed using the Illumina BovineHD BeadChip according to the Infinium protocol. Moving average of -logP was used to map QTLs and Log drop was used to define their boundaries (QTLRs). The combined procedure was efficient for high resolution mapping. Nineteen QTLRs distributed over 13 autosomes were found, some overlapping previous studies. The QTLRs contain polymorphic functional and expression candidate genes to affect kosher status, with putative immunological and wound healing activities. Kosher phenotyping was shown to be a reliable means to map QTLs affecting BRD morbidity. PMID:27077383

Football and post-war reintegration: exploring the role of sport in DDR processes in Sierra Leone.

PubMed

Dyck, Christopher B

2011-01-01

Growing enthusiasm for 'Sport for development and peace' (SDP) projects around the world has created a much greater interest among critical scholars seeking to interrogate potential gains, extant limitations and challenges of using sport to advance 'development' and 'peace' in Africa. Despite this interest, the role of sport in post-conflict peace building remains poorly understood. Since peace building, as a field of study, lends itself to practical approaches that seek to address underlying sources of violent conflict, it is surprising that it has neglected to take an interest in sport, especially its grassroots models. In Africa, football (soccer) in particular has a strong appeal because of its popularity and ability to mobilise individuals and communities. Through a case study on Sierra Leone, this paper focuses on sports in a particularly prominent post-civil war UN intervention—the disarmament, demobilisation and reintegration (DDR) process—to determine how ex-youth combatants, camp administrators and caregivers perceive the role and significance of sporting activities in interim care centres (ICCS) or DDR camps. It argues that sporting experiences in ddr processes are fruitful microcosms for understanding nuanced forms of violence and healing among youth combatants during their reintegration process.

Pursuit-evasion games with information uncertainties for elusive orbital maneuver and space object tracking

NASA Astrophysics Data System (ADS)

Shen, Dan; Jia, Bin; Chen, Genshe; Blasch, Erik; Pham, Khanh

2015-05-01

This paper develops and evaluates a pursuit-evasion (PE) game approach for elusive orbital maneuver and space object tracking. Unlike the PE games in the literature, where the assumption is that either both players have perfect knowledge of the opponents' positions or use primitive sensing models, the proposed PE approach solves the realistic space situation awareness (SSA) problem with imperfect information, where the evaders will exploit the pursuers' sensing and tracking models to confuse their opponents by maneuvering their orbits to increase the uncertainties, which the pursuers perform orbital maneuvers to minimize. In the game setup, each game player P (pursuer) and E (evader) has its own motion equations with a small continuous low-thrust. The magnitude of the low thrust is fixed and the direction can be controlled by the associated game player. The entropic uncertainty is used to generate the cost functions of game players. The Nash or mixed Nash equilibrium is composed of the directional controls of low-thrusts. Numerical simulations are emulated to demonstrate the performance. Simplified perturbations models (SGP4/SDP4) are exploited to calculate the ground truth of the satellite states (position and speed).

Final Report from The University of Texas at Austin for DEGAS: Dynamic Global Address Space programming environments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erez, Mattan; Yelick, Katherine; Sarkar, Vivek

The Dynamic, Exascale Global Address Space programming environment (DEGAS) project will develop the next generation of programming models and runtime systems to meet the challenges of Exascale computing. Our approach is to provide an efficient and scalable programming model that can be adapted to application needs through the use of dynamic runtime features and domain-specific languages for computational kernels. We address the following technical challenges: Programmability: Rich set of programming constructs based on a Hierarchical Partitioned Global Address Space (HPGAS) model, demonstrated in UPC++. Scalability: Hierarchical locality control, lightweight communication (extended GASNet), and ef- ficient synchronization mechanisms (Phasers). Performance Portability:more » Just-in-time specialization (SEJITS) for generating hardware-specific code and scheduling libraries for domain-specific adaptive runtimes (Habanero). Energy Efficiency: Communication-optimal code generation to optimize energy efficiency by re- ducing data movement. Resilience: Containment Domains for flexible, domain-specific resilience, using state capture mechanisms and lightweight, asynchronous recovery mechanisms. Interoperability: Runtime and language interoperability with MPI and OpenMP to encourage broad adoption.« less

Alternate space station freedom configuration considerations to accommodate solar dynamic power

NASA Technical Reports Server (NTRS)

Deryder, L. J.; Cruz, J. N.; Heck, M. L.; Robertson, B. P.; Troutman, P. A.

1989-01-01

The results of a technical audit of the Space Station Freedom Program conducted by the Program Director was announced in early 1989 and included a proposal to use solar dynamic power generation systems to provide primary electrical energy for orbital flight operations rather than photovoltaic solar array systems. To generate the current program baseline power of 75 kW, two or more solar concentrators approximately 50 feet in diameter would be required to replace four pairs of solar arrays whose rectangular blanket size is approximately 200 feet by 30 feet. The photovoltaic power system concept uses solar arrays to generate electricity that is stored in nickel-hydrogen batteries. The proposed concept uses the solar concentrator dishes to reflect and focus the Sun's energy to heat helium-xenon gas to drive electricity generating turbines. The purpose here is to consider the station configuration issues for incorporation of solar dynamic power system components. Key flight dynamic configuration geometry issues are addressed and an assembly sequence scenario is developed.

Planning Future Instructional Programs through Computerized L2 Dynamic Assessment

ERIC Educational Resources Information Center

Ebadi, Saman; Saeedian, Abdulbaset

2016-01-01

Dynamic Assessment (DA) is a postmodern notion in testing which sees instruction and assessment as inextricably mingled contending that learners will progress if provided with dynamic interactions. The main purpose of the study is to see if the scores generated by the computerized dynamic assessment (C-DA) which is grounded in Vygotsky's…

Mapping the information landscape: Discerning peaks and valleys for ecological monitoring

USGS Publications Warehouse

Moniz, L.J.; Nichols, J.D.; Nichols, J.M.

2007-01-01

We investigate previously unreported phenomena that have a potentially significant impact on the design of surveillance monitoring programs for ecological systems. Ecological monitoring practitioners have long recognized that different species are differentially informative of a system?s dynamics, as codified in the well-known concepts of indicator or keystone species. Using a novel combination of analysis techniques from nonlinear dynamics, we describe marked variation among spatial sites in information content with respect to system dynamics in the entire region. We first observed these phenomena in a spatially extended predator?prey model, but we observed strikingly similar features in verified water-level data from a NOAA/NOS Great Lakes monitoring program. We suggest that these features may be widespread and the design of surveillance monitoring programs should reflect knowledge of their existence.

Adaptive critic designs for discrete-time zero-sum games with application to H(infinity) control.

PubMed

Al-Tamimi, Asma; Abu-Khalaf, Murad; Lewis, Frank L

2007-02-01

In this correspondence, adaptive critic approximate dynamic programming designs are derived to solve the discrete-time zero-sum game in which the state and action spaces are continuous. This results in a forward-in-time reinforcement learning algorithm that converges to the Nash equilibrium of the corresponding zero-sum game. The results in this correspondence can be thought of as a way to solve the Riccati equation of the well-known discrete-time H(infinity) optimal control problem forward in time. Two schemes are presented, namely: 1) a heuristic dynamic programming and 2) a dual-heuristic dynamic programming, to solve for the value function and the costate of the game, respectively. An H(infinity) autopilot design for an F-16 aircraft is presented to illustrate the results.

Synthesizing Dynamic Programming Algorithms from Linear Temporal Logic Formulae

NASA Technical Reports Server (NTRS)

Rosu, Grigore; Havelund, Klaus

2001-01-01

The problem of testing a linear temporal logic (LTL) formula on a finite execution trace of events, generated by an executing program, occurs naturally in runtime analysis of software. We present an algorithm which takes an LTL formula and generates an efficient dynamic programming algorithm. The generated algorithm tests whether the LTL formula is satisfied by a finite trace of events given as input. The generated algorithm runs in linear time, its constant depending on the size of the LTL formula. The memory needed is constant, also depending on the size of the formula.

Update of the 2 Kw Solar Dynamic Ground Test Demonstration Program

NASA Technical Reports Server (NTRS)

Shaltens, Richard K.; Boyle, Robert V.

1994-01-01

The Solar Dynamic (SD) Ground Test Demonstration (GTD) program demonstrates the operation of a complete 2 kW, SD system in a simulated space environment at a NASA Lewis Research Center (LeRC) thermal-vacuum facility. This paper reviews the goals and status of the SD GTD program. A brief description of the SD system identifying key design features of the system, subsystems, and components is included. An aerospace industry/government team is working together to design, fabricate, assemble, and test a complete SD system.

HARP model rotor test at the DNW. [Hughes Advanced Rotor Program

NASA Technical Reports Server (NTRS)

Dawson, Seth; Jordan, David; Smith, Charles; Ekins, James; Silverthorn, Lou

1989-01-01

Data from a test of a dynamically scaled model of the Hughes Advanced Rotor Program (HARP) bearingless model main rotor and 369K tail rotor are reported. The history of the HARP program and its goals are reviewed, and the main and tail rotor models are described. The test facilities and instrumentation are described, and wind tunnel test data are presented on hover, forward flight performance, and blade-vortex interaction. Performance data, acoustic data, and dynamic data from near field/far field and shear layer studies are presented.

Technical evaluation report of AGARD Technical Evaluation Meeting on Unsteady Aerodynamics: Fundamentals and Applications to Aircraft Dynamics

NASA Technical Reports Server (NTRS)

Mabey, D. G.; Chambers, J. R.

1986-01-01

From May 6 to 9, 1985, the Fluid Dynamics Panel and Flight Mechanics Panel of AGARD jointly arranged a Symposium on Unsteady Aerodynamics-Fundamentals and Applications to Aircraft Dynamics at the Stadthall, Goettingen, West Germany. This Symposium was organized by an international program committee chaired by Dr. K. J. Orlik-Ruckemann of the Fluid Dynamics Panel. The program consisted of five sessions grouped in two parts: (1) Fundamentals of Unsteady Aerodynamics; and (2) Applications to Aircraft Dynamics. The 35 papers presented at the 4 day meeting are published in AGARD CP 386 and listed in the Appendix. As the papers are already available and cover a very wide field, the evaluators have offered brief comments on every paper, followed by an overall evaluation of the meeting, together with some general conclusions and recommendations.