Satellite-tracking and earth-dynamics research programs. [geodetic and geophysical investigations and atmospheric research using satellite drag data

NASA Technical Reports Server (NTRS)

1972-01-01

Satellite tracking and earth dynamics research programs are discussed. Geodetic and geophysical investigations are reported along with atmospheric research using satellite drag data. Satellite tracking network functions and support groups which are discussed include: network operations, communications, data-services division, moonwatch, and programming group.

Surveying the Dynamic Radio Sky with the Long Wavelength Demonstrator Array

DTIC Science & Technology

2010-10-01

and potentially the Lunar Radio Array. Subject headings: instrumentation: interferometers — methods : observational — radio continuum: gen- eral 1Remote...Sensing Division, Naval Research Laboratory, 4555 Overlook Ave. SW, Washington, DC 20375 USA 2NASA Lunar Science Institute, NASA Ames Research Center...Moffett Field, CA 94035 USA 3Space Science Division, Naval Research Laboratory, 4555 Overlook Ave. SW, Washington, DC 20375-5382 USA 4Praxis, Inc

Lead from the center. How to manage divisions dynamically.

PubMed

Raynor, M E; Bower, J L

2001-05-01

Conventional wisdom holds that a company's divisions should be given almost total autonomy--especially under conditions of uncertainty--because they are closer to emerging technologies, customers, and competitors than corporate headquarters could ever be. But research from Michael Raynor and Joseph Bower suggests that the corporate office should be more, not less, directive in turbulent markets. Rapid changes in an industry make it difficult to predict where and when synergies among divisions might emerge. With so many possibilities and such uncertainty, companies can't afford to sacrifice their ability to flexibly execute business strategy. Corporate headquarters must play an active role in defining the scope of division-level strategy, the authors say, so that divisions do not act in ways that undermine opportunities to collaborate in the future. But neither can companies afford to sacrifice the competitiveness of their divisions as stand-alone businesses. In creating corporate-level strategic flexibility, a corporate office must balance the need for divisional autonomy now with the potential need for cooperation in the future. Through an examination of four corporations--Sprint, WPP, Teradyne, and Viacom--the authors challenge traditional approaches to diversification in which a company's divisions are either related (they share resources and collaborate) or unrelated (they compete for resources and operate as stand-alone businesses). They argue that companies should adopt a dynamic approach to cooperation among divisions, enabling varying degrees of relatedness between divisions depending on strategic circumstances. The authors offer four tactics to help executives manage divisions dynamically.

Lewis Structures Technology, 1988. Volume 3: Structural Integrity Fatigue and Fracture Wind Turbines HOST

NASA Technical Reports Server (NTRS)

1988-01-01

The charter of the Structures Division is to perform and disseminate results of research conducted in support of aerospace engine structures. These results have a wide range of applicability to practioners of structural engineering mechanics beyond the aerospace arena. The specific purpose of the symposium was to familiarize the engineering structures community with the depth and range of research performed by the division and its academic and industrial partners. Sessions covered vibration control, fracture mechanics, ceramic component reliability, parallel computing, nondestructive evaluation, constitutive models and experimental capabilities, dynamic systems, fatigue and damage, wind turbines, hot section technology (HOST), aeroelasticity, structural mechanics codes, computational methods for dynamics, structural optimization, and applications of structural dynamics, and structural mechanics computer codes.

Lewis Structures Technology, 1988. Volume 1: Structural Dynamics

NASA Technical Reports Server (NTRS)

1988-01-01

The specific purpose of the symposium was to familiarize the engineering structures community with the depth and range of research performed by the Structures Division of the Lewis Research Center and its academic and industrial partners. Sessions covered vibration control, fracture mechanics, ceramic component reliability, parallel computing, nondestructive testing, dynamical systems, fatigue and damage, wind turbines, hot section technology, structural mechanics codes, computational methods for dynamics, structural optimization, and applications of structural dynamics.

77 FR 35060 - Pfizer Therapeutic Research, Formerly Known as Warner Lambert Company, Pfizer Worldwide Research...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-12

... Research, Formerly Known as Warner Lambert Company, Pfizer Worldwide Research & Development Division, Antibacterials Research Unit, Pharmacokinetics, Dynamics and Metabolism Department, Antibacterial Chemistry... Regarding Eligibility To Apply for Worker Adjustment Assistance In accordance with Section 223 of the Trade...

Futurepath: The Story of Research and Technology at NASA Lewis Research Center. Structures for Flight Propulsion, ARC Sprayed Monotape, National Aero-Space Plane

NASA Technical Reports Server (NTRS)

1989-01-01

The story of research and technology at NASA Lewis Research Center's Structures Division is presented. The job and designs of the Structures Division needed for flight propulsion is described including structural mechanics, structural dynamics, fatigue, and fracture. The video briefly explains why properties of metals used in structural mechanics need to be tested. Examples of tests and simulations used in structural dynamics (bodies in motion) are briefly described. Destructive and non-destructive fatigue/fracture analysis is also described. The arc sprayed monotape (a composite material) is explained, as are the programs in which monotape plays a roll. Finally, the National Aero-Space Plane (NASP or x-30) is introduced, including the material development and metal matrix as well as how NASP will reduce costs for NASA.

Phoenix, a High-Performance UNIX with an Emphasis on Dynamic Modification, Real-Time Response and Survivability

DTIC Science & Technology

1990-01-12

Communications COM-28, (April 1980 ) 425-432. [6] Munch-Anderson, B. and T.U. Zahle, Scheduling According to Job Priority With Prevention of Deadlock and...Interconnection, IEEE Transactions on Communications COM-28, (April 1980 ) 425-432. (4] Cook, R.P., StarMod, A Language for Distributed Programming...Research Triangle Park, NC 27709-2211 Attention: Dr. David W. Hislop * Electronics Division 51 Dr. David W. Hislop Electronics Division U. S. Army Research

NASA earth science and applications division: The program and plans for FY 1988-1989-1990

NASA Technical Reports Server (NTRS)

1988-01-01

Described here are the Division's research goals, priorities and emphases for the next several years and an outline of longer term plans. Included are highlights of recent accomplishments, current activities in FY 1988, research emphases in FY 1989, and longer term future plans. Data and information systems, the Geodynamics Program, the Land Processes Program, the Oceanic Processes Program, the Atmospheric Dynamics and Radiation Program, the Atmospheric Chemistry Program, and space flight programs are among the topic covered.

Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy

NASA Astrophysics Data System (ADS)

Kemper, Björn; Bauwens, Andreas; Vollmer, Angelika; Ketelhut, Steffi; Langehanenberg, Patrik; Müthing, Johannes; Karch, Helge; von Bally, Gert

2010-05-01

Digital holographic microscopy (DHM) enables quantitative multifocus phase contrast imaging for nondestructive technical inspection and live cell analysis. Time-lapse investigations on human brain microvascular endothelial cells demonstrate the use of DHM for label-free dynamic quantitative monitoring of cell division of mother cells into daughter cells. Cytokinetic DHM analysis provides future applications in toxicology and cancer research.

Summary of the NASA/MSFC FY-79 Severe Storm and Local Weather research review. [cloud physics, atmospheric electricity, and mesoscale/storm dynamics reserach

NASA Technical Reports Server (NTRS)

1979-01-01

Significant acomplishments, current focus of work, plans for FY-80, and recommendations for new research are outlined for 36 research projects proposed for technical monitoring by the Atmospheric Sciences Division at Marshall Space Flight Center. Topics of the investigations, which were reviewed at a two-day meeting, relate to cloud physics, atmospheric electricity, and mesoscale/storm dynamics.

Chemistry Division annual progress report for period ending April 30, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poutsma, M.L.; Ferris, L.M.; Mesmer, R.E.

1993-08-01

The Chemistry Division conducts basic and applied chemical research on projects important to DOE`s missions in sciences, energy technologies, advanced materials, and waste management/environmental restoration; it also conducts complementary research for other sponsors. The research are arranged according to: coal chemistry, aqueous chemistry at high temperatures and pressures, geochemistry, chemistry of advanced inorganic materials, structure and dynamics of advanced polymeric materials, chemistry of transuranium elements and compounds, chemical and structural principles in solvent extraction, surface science related to heterogeneous catalysis, photolytic transformations of hazardous organics, DNA sequencing and mapping, and special topics.

A Study of Federal Academic Earmarks and Research Funding in Relation to the Institutional Research Culture of Research University/High (RU/H) Institutions in Mississippi

ERIC Educational Resources Information Center

Young, James Hubert, III

2013-01-01

Nationally, reductions in public funding for higher education, a stagnate economy, looming sequestration, and a divisive political culture present a complex and challenging dynamic for research universities in pursuit of external funding for their research programs and infrastructure needs. These universities and their research initiatives have…

Genes and the Microenvironment: Two Faces of Breast Cancer (LBNL Science at the Theater)

ScienceCinema

Gray, Joe; Love, Susan M.; Bissell, Min; Barcellos-Hoff, Mary Helen

2018-05-24

In this April 21, 2008 Berkeley Lab event, a dynamic panel of Berkeley Lab scientists highlight breast cancer research advances related to susceptibility, early detection, prevention, and therapy - a biological systems approach to tackling the disease from the molecular and cellular levels, to tissues and organs, and ultimately the whole individual. Joe Gray, Berkeley Lab Life Sciences Division Director, explores how chromosomal abnormalities contribute to cancer and respond to gene-targeted therapies. Mina Bissell, former Life Sciences Division Director, approaches the challenge of breast cancer from the breast's three dimensional tissue microenvironment and how the intracellular ''conversation'' triggers malignancies. Mary Helen Barcellos-Hoff, Deputy Director, Life Sciences Division, identifies what exposure to ionizing radiation can tell us about how normal tissues suppress carcinogenesis. The panel is moderated by Susan M. Love, breast cancer research pioneer, author, President and Medical Director of the Dr. Susan Love Research Foundation.

Genes and the Microenvironment: Two Faces of Breast Cancer (LBNL Science at the Theater)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gray, Joe; Love, Susan M.; Bissell, Min

In this April 21, 2008 Berkeley Lab event, a dynamic panel of Berkeley Lab scientists highlight breast cancer research advances related to susceptibility, early detection, prevention, and therapy - a biological systems approach to tackling the disease from the molecular and cellular levels, to tissues and organs, and ultimately the whole individual. Joe Gray, Berkeley Lab Life Sciences Division Director, explores how chromosomal abnormalities contribute to cancer and respond to gene-targeted therapies. Mina Bissell, former Life Sciences Division Director, approaches the challenge of breast cancer from the breast's three dimensional tissue microenvironment and how the intracellular ''conversation'' triggers malignancies. Marymore » Helen Barcellos-Hoff, Deputy Director, Life Sciences Division, identifies what exposure to ionizing radiation can tell us about how normal tissues suppress carcinogenesis. The panel is moderated by Susan M. Love, breast cancer research pioneer, author, President and Medical Director of the Dr. Susan Love Research Foundation.« less

Gender Dynamics Predict Changes in Marital Love Among African American Couples

PubMed Central

Stanik, Christine E.; McHale, Susan M.; Crouter, Ann C.

2013-01-01

This study examined the implications of gender attitudes and spouses’ divisions of household labor, time with children, and parental knowledge for their trajectories of love in a sample of 146 African American couples. Multilevel modeling in the context of an accelerated longitudinal design accommodated 3 annual waves of data. The results revealed that traditionality in husbands’ gender attitudes was linked to lower levels of love. Furthermore, divisions of household labor and parental knowledge moderated changes in love such that couples with more egalitarian divisions exhibited higher and more stable patterns of love, whereas more traditional couples exhibited significant declines in love over time. Finally, greater similarity between spouses’ time with their children was linked to higher levels of marital love. The authors highlight the implications of gender dynamics for marital harmony among African American couples and discuss ways that this work may be applied and extended in practice and future research. PMID:23956462

Activities of the Structures Division, Lewis Research Center

NASA Technical Reports Server (NTRS)

1990-01-01

The purpose of the NASA Lewis Research Center, Structures Division's 1990 Annual Report is to give a brief, but comprehensive, review of the technical accomplishments of the Division during the past calendar year. The report is organized topically to match the Center's Strategic Plan. Over the years, the Structures Division has developed the technology base necessary for improving the future of aeronautical and space propulsion systems. In the future, propulsion systems will need to be lighter, to operate at higher temperatures and to be more reliable in order to achieve higher performance. Achieving these goals is complex and challenging. Our approach has been to work cooperatively with both industry and universities to develop the technology necessary for state-of-the-art advancement in aeronautical and space propulsion systems. The Structures Division consists of four branches: Structural Mechanics, Fatigue and Fracture, Structural Dynamics, and Structural Integrity. This publication describes the work of the four branches by three topic areas of Research: (1) Basic Discipline; (2) Aeropropulsion; and (3) Space Propulsion. Each topic area is further divided into the following: (1) Materials; (2) Structural Mechanics; (3) Life Prediction; (4) Instruments, Controls, and Testing Techniques; and (5) Mechanisms. The publication covers 78 separate topics with a bibliography containing 159 citations. We hope you will find the publication interesting as well as useful.

FOOD WEB AND COMMUNITY COMPOSITION CHANGES IN RESPONSE TO NUTRIENT LOADING IN FRESHWATER AND MARINE COASTAL SYSTEMS (ESTUARIES AND COASTAL WETLANDS)

EPA Science Inventory

Our research will investigate the mechanisms by which increased loading of nutrients to coastal waters alters the structure and dynamics of food webs, resulting in declines in populations of ecologically and commercially important organisms. Research across NHEERL Divisions will...

AN INTEGRATED WATERSHED APPROACH LINKING SALMONID PRODUCTIVITY TO FRESHWATER HABITAT

EPA Science Inventory

EPA's Western Ecology Division is undertaking research addressing catchment-scale dynamics of freshwater habitat productivity for native fishes. Through partnerships with state and federal agencies and private landowners, current field efforts focus on linkages among stream chemi...

Competitive Advantage in Intercollegiate Athletics: Role of Intangible Resources.

PubMed

Won, Doyeon; Chelladurai, Packianathan

2016-01-01

The present research explored the dynamics of competitive advantages in intercollegiate athletics by investigating the contribution of intangible resources (i.e., athletic and academic reputations) on the generation of more tangible resources (i.e., human and financial resources), which in turn influence the athletic performance (i.e., winning record) and academic performance (i.e., graduation rates), and gender equity. The research was based entirely on archival data of 324 NCAA Division I member institutions. The results of the SEM supported the study's basic arguments that tangible resources are the sources of competitive advantages in Division I intercollegiate athletics, and that intangible resources contribute to the generation of tangible resources.

Navy DD(X), CG(X), and LCS Ship Acquisition Programs: Oversight Issues and Options for Congress

DTIC Science & Technology

2005-04-21

6. AUTHOR(S) 5d. PROJECT NUMBER 5e . TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Congressional Research...between Northrop Grumman’s Ship System Division ( NGSS ) and General Dynamics’ Bath Iron Works (GD/BIW) for the right to build all DD(X)s. Several Members...premature” a Navy proposal to hold a one-time, winner-take-all competition between Northrop Grumman’s Ship System Division ( NGSS ) and General Dynamics

Fish everywhere, all the time: modeling fish in the riverscape

EPA Science Inventory

From 2002-2006, EPA’s Western Ecology Division conducted innovative research on the population dynamics of fish within an entire stream network. Employing individual tagging and tracking technology, we examined spatial patterns of juvenile coho salmon (Oncorhynchus kisutch...

Preparation of a Manuscript on Leadership Dynamics.

DTIC Science & Technology

1977-11-01

Sciences Division, Office of Naval Research IB- KEY WORDS (Confirm* en feverae »Id» II rfc*,,mr, and Identity fey Meek number,) Leadership ... Management , Supervision Leader-Follower Relations Leadership Effectiveness, 3roup and Organizational Performance, Planned Change j 20. ABSTRACT

Atmospheric Research 2016 Technical Highlights

NASA Technical Reports Server (NTRS)

Platnick, Steven

2017-01-01

Atmospheric research in the Earth Sciences Division (610) consists of research and technology development programs dedicated to advancing knowledge and understanding of the atmosphere and its interaction with the climate of Earth. The Divisions goals are to improve understanding of the dynamics and physical properties of precipitation, clouds, and aerosols; atmospheric chemistry, including the role of natural and anthropogenic trace species on the ozone balance in the stratosphere and the troposphere; and radiative properties of Earth's atmosphere and the influence of solar variability on the Earth's climate. Major research activities are carried out in the Mesoscale Atmospheric Processes Laboratory, the Climate and Radiation Laboratory, the Atmospheric Chemistry and Dynamics Laboratory, and the Wallops Field Support Office. The overall scope of the research covers an end-to-end process, starting with the identification of scientific problems, leading to observation requirements for remote-sensing platforms, technology and retrieval algorithm development; followed by flight projects and satellite missions; and eventually, resulting in data processing, analyses of measurements, and dissemination from flight projects and missions. Instrument scientists conceive, design, develop, and implement ultraviolet, infrared, optical, radar, laser, and lidar technology to remotely sense the atmosphere. Members of the various laboratories conduct field measurements for satellite sensor calibration and data validation, and carry out numerous modeling activities. These modeling activities include climate model simulations, modeling the chemistry and transport of trace species on regional-to-global scales, cloud resolving models, and developing the next-generation Earth system models. Satellite missions, field campaigns, peer-reviewed publications, and successful proposals are essential at every stage of the research process to meeting our goals and maintaining leadership of the Earth Sciences Division in atmospheric science research. Figure 1.1 shows the 22-year record of peer-reviewed publications and proposals among the various laboratories.

Lewis Structures Technology, 1988. Volume 2: Structural Mechanics

NASA Technical Reports Server (NTRS)

1988-01-01

Lewis Structures Div. performs and disseminates results of research conducted in support of aerospace engine structures. These results have a wide range of applicability to practitioners of structural engineering mechanics beyond the aerospace arena. The engineering community was familiarized with the depth and range of research performed by the division and its academic and industrial partners. Sessions covered vibration control, fracture mechanics, ceramic component reliability, parallel computing, nondestructive evaluation, constitutive models and experimental capabilities, dynamic systems, fatigue and damage, wind turbines, hot section technology (HOST), aeroelasticity, structural mechanics codes, computational methods for dynamics, structural optimization, and applications of structural dynamics, and structural mechanics computer codes.

Variable threshold algorithm for division of labor analyzed as a dynamical system.

PubMed

Castillo-Cagigal, Manuel; Matallanas, Eduardo; Navarro, Iñaki; Caamaño-Martín, Estefanía; Monasterio-Huelin, Félix; Gutiérrez, Álvaro

2014-12-01

Division of labor is a widely studied aspect of colony behavior of social insects. Division of labor models indicate how individuals distribute themselves in order to perform different tasks simultaneously. However, models that study division of labor from a dynamical system point of view cannot be found in the literature. In this paper, we define a division of labor model as a discrete-time dynamical system, in order to study the equilibrium points and their properties related to convergence and stability. By making use of this analytical model, an adaptive algorithm based on division of labor can be designed to satisfy dynamic criteria. In this way, we have designed and tested an algorithm that varies the response thresholds in order to modify the dynamic behavior of the system. This behavior modification allows the system to adapt to specific environmental and collective situations, making the algorithm a good candidate for distributed control applications. The variable threshold algorithm is based on specialization mechanisms. It is able to achieve an asymptotically stable behavior of the system in different environments and independently of the number of individuals. The algorithm has been successfully tested under several initial conditions and number of individuals.

Competitive Advantage in Intercollegiate Athletics: Role of Intangible Resources

PubMed Central

Won, Doyeon; Chelladurai, Packianathan

2016-01-01

The present research explored the dynamics of competitive advantages in intercollegiate athletics by investigating the contribution of intangible resources (i.e., athletic and academic reputations) on the generation of more tangible resources (i.e., human and financial resources), which in turn influence the athletic performance (i.e., winning record) and academic performance (i.e., graduation rates), and gender equity. The research was based entirely on archival data of 324 NCAA Division I member institutions. The results of the SEM supported the study’s basic arguments that tangible resources are the sources of competitive advantages in Division I intercollegiate athletics, and that intangible resources contribute to the generation of tangible resources. PMID:26731118

A Bibliometric Analysis on Cancer Population Science with Topic Modeling.

PubMed

Li, Ding-Cheng; Rastegar-Mojarad, Majid; Okamoto, Janet; Liu, Hongfang; Leichow, Scott

2015-01-01

Bibliometric analysis is a research method used in library and information science to evaluate research performance. It applies quantitative and statistical analyses to describe patterns observed in a set of publications and can help identify previous, current, and future research trends or focus. To better guide our institutional strategic plan in cancer population science, we conducted bibliometric analysis on publications of investigators currently funded by either Division of Cancer Preventions (DCP) or Division of Cancer Control and Population Science (DCCPS) at National Cancer Institute. We applied two topic modeling techniques: author topic modeling (AT) and dynamic topic modeling (DTM). Our initial results show that AT can address reasonably the issues related to investigators' research interests, research topic distributions and popularities. In compensation, DTM can address the evolving trend of each topic by displaying the proportion changes of key words, which is consistent with the changes of MeSH headings.

An Overview-NASA LeRC Structures Program

NASA Technical Reports Server (NTRS)

Zaretsky, Erwin V.

1997-01-01

The Structures and Acoustics Division of the NASA Lewis Research Center has its genesis dating back to 1943. It has been an independent Division at Lewis since 1979. Its two primary capabilities are performance and life analysis of static and dynamic systems such as those found in aircraft and spacecraft propulsion systems and experimental verification of these analyses. Research is conducted in-house, through university grants and contracts, and through cooperative programs with industry. Our work directly supports NASA's Advanced Subsonic Technology (AST), Smart Green Engine, Fast Quiet Engine, High-Temperature Materials and Processing (HiTEMP), Hybrid Hyperspeed Propulsion, Rotorcraft, High-Speed Research (HSR), and Aviation Safety Program (AvSP). A general overview is given discussing these programs and other technologies that are being developed at NASA LeRC.

Gain control through divisive inhibition prevents abrupt transition to chaos in a neural mass model.

PubMed

Papasavvas, Christoforos A; Wang, Yujiang; Trevelyan, Andrew J; Kaiser, Marcus

2015-09-01

Experimental results suggest that there are two distinct mechanisms of inhibition in cortical neuronal networks: subtractive and divisive inhibition. They modulate the input-output function of their target neurons either by increasing the input that is needed to reach maximum output or by reducing the gain and the value of maximum output itself, respectively. However, the role of these mechanisms on the dynamics of the network is poorly understood. We introduce a novel population model and numerically investigate the influence of divisive inhibition on network dynamics. Specifically, we focus on the transitions from a state of regular oscillations to a state of chaotic dynamics via period-doubling bifurcations. The model with divisive inhibition exhibits a universal transition rate to chaos (Feigenbaum behavior). In contrast, in an equivalent model without divisive inhibition, transition rates to chaos are not bounded by the universal constant (non-Feigenbaum behavior). This non-Feigenbaum behavior, when only subtractive inhibition is present, is linked to the interaction of bifurcation curves in the parameter space. Indeed, searching the parameter space showed that such interactions are impossible when divisive inhibition is included. Therefore, divisive inhibition prevents non-Feigenbaum behavior and, consequently, any abrupt transition to chaos. The results suggest that the divisive inhibition in neuronal networks could play a crucial role in keeping the states of order and chaos well separated and in preventing the onset of pathological neural dynamics.

INFLUENCE OF STREAM NETWORK-SCALE HABITAT OF A COASTAL OREGON WATERSHED ON COHO SALMON AND OTHER NATIVE FISH

EPA Science Inventory

EPA's Western Ecology Division is undertaking research addressing catchment-scale dynamics of freshwater habitat productivity for native fishes. Through partnerships with state and federal agencies and private landowners, current field efforts focus on linkages among stream chemi...

Introduction to Robust Multivariable Control

DTIC Science & Technology

1986-02-01

AX DAVIS, Assistant for Research and Technology Flight Control Division Flight Dynamics Laboratory "If your address has changed, if you wish to be...particular chapter is given at the end of each chapter. It is needless to say that there are numerour other - publications in this area of controls research ...tco in this Area of research comprehensively in a single report. Finally, even though most of the material in this report comes from publications of W

Thermosphere-ionosphere-mesosphere energetics and dynamics (TIMED). The TIMED mission and science program report of the science definition team. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1991-01-01

A Science Definition Team was established in December 1990 by the Space Physics Division, NASA, to develop a satellite program to conduct research on the energetics, dynamics, and chemistry of the mesosphere and lower thermosphere/ionosphere. This two-volume publication describes the TIMED (Thermosphere-Ionosphere-Mesosphere, Energetics and Dynamics) mission and associated science program. The report outlines the scientific objectives of the mission, the program requirements, and the approach towards meeting these requirements.

Gain control through divisive inhibition prevents abrupt transition to chaos in a neural mass model

PubMed Central

Papasavvas, Christoforos A.; Wang, Yujiang; Trevelyan, Andrew J.; Kaiser, Marcus

2016-01-01

Experimental results suggest that there are two distinct mechanisms of inhibition in cortical neuronal networks: subtractive and divisive inhibition. They modulate the input-output function of their target neurons either by increasing the input that is needed to reach maximum output or by reducing the gain and the value of maximum output itself, respectively. However, the role of these mechanisms on the dynamics of the network is poorly understood. We introduce a novel population model and numerically investigate the influence of divisive inhibition on network dynamics. Specifically, we focus on the transitions from a state of regular oscillations to a state of chaotic dynamics via period-doubling bifurcations. The model with divisive inhibition exhibits a universal transition rate to chaos (Feigenbaum behavior). In contrast, in an equivalent model without divisive inhibition, transition rates to chaos are not bounded by the universal constant (non-Feigenbaum behavior). This non-Feigenbaum behavior, when only subtractive inhibition is present, is linked to the interaction of bifurcation curves in the parameter space. Indeed, searching the parameter space showed that such interactions are impossible when divisive inhibition is included. Therefore, divisive inhibition prevents non-Feigenbaum behavior and, consequently, any abrupt transition to chaos. The results suggest that the divisive inhibition in neuronal networks could play a crucial role in keeping the states of order and chaos well separated and in preventing the onset of pathological neural dynamics. PMID:26465514

A dynamic systems engineering methodology research study. Phase 2: Evaluating methodologies, tools, and techniques for applicability to NASA's systems projects

NASA Technical Reports Server (NTRS)

Paul, Arthur S.; Gill, Tepper L.; Maclin, Arlene P.

1989-01-01

A study of NASA's Systems Management Policy (SMP) concluded that the primary methodology being used by the Mission Operations and Data Systems Directorate and its subordinate, the Networks Division, is very effective. Still some unmet needs were identified. This study involved evaluating methodologies, tools, and techniques with the potential for resolving the previously identified deficiencies. Six preselected methodologies being used by other organizations with similar development problems were studied. The study revealed a wide range of significant differences in structure. Each system had some strengths but none will satisfy all of the needs of the Networks Division. Areas for improvement of the methodology being used by the Networks Division are listed with recommendations for specific action.

143. GENERAL DYNAMICS SPACE SYSTEMS DIVISION SCHEDULE BOARD IN LUNCH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

143. GENERAL DYNAMICS SPACE SYSTEMS DIVISION SCHEDULE BOARD IN LUNCH ROOM (120), LSB (BLDG. 770) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

A dynamic multi-scale Markov model based methodology for remaining life prediction

NASA Astrophysics Data System (ADS)

Yan, Jihong; Guo, Chaozhong; Wang, Xing

2011-05-01

The ability to accurately predict the remaining life of partially degraded components is crucial in prognostics. In this paper, a performance degradation index is designed using multi-feature fusion techniques to represent deterioration severities of facilities. Based on this indicator, an improved Markov model is proposed for remaining life prediction. Fuzzy C-Means (FCM) algorithm is employed to perform state division for Markov model in order to avoid the uncertainty of state division caused by the hard division approach. Considering the influence of both historical and real time data, a dynamic prediction method is introduced into Markov model by a weighted coefficient. Multi-scale theory is employed to solve the state division problem of multi-sample prediction. Consequently, a dynamic multi-scale Markov model is constructed. An experiment is designed based on a Bently-RK4 rotor testbed to validate the dynamic multi-scale Markov model, experimental results illustrate the effectiveness of the methodology.

Dynamic bandwidth allocation based on multiservice in software-defined wavelength-division multiplexing time-division multiplexing passive optical network

NASA Astrophysics Data System (ADS)

Wang, Fu; Liu, Bo; Zhang, Lijia; Jin, Feifei; Zhang, Qi; Tian, Qinghua; Tian, Feng; Rao, Lan; Xin, Xiangjun

2017-03-01

The wavelength-division multiplexing passive optical network (WDM-PON) is a potential technology to carry multiple services in an optical access network. However, it has the disadvantages of high cost and an immature technique for users. A software-defined WDM/time-division multiplexing PON was proposed to meet the requirements of high bandwidth, high performance, and multiple services. A reasonable and effective uplink dynamic bandwidth allocation algorithm was proposed. A controller with dynamic wavelength and slot assignment was introduced, and a different optical dynamic bandwidth management strategy was formulated flexibly for services of different priorities according to the network loading. The simulation compares the proposed algorithm with the interleaved polling with adaptive cycle time algorithm. The algorithm shows better performance in average delay, throughput, and bandwidth utilization. The results show that the delay is reduced to 62% and the throughput is improved by 35%.

Permafrost, Seasonally Frozen Ground, Snow Cover and Vegetation in the USSR

DTIC Science & Technology

1984-12-01

Snow Cover in Physical Geographic Processes (1948). He covered aspects of the dynamics of the snow cover, its properties and the connection between...Bigl, Research Physical Scientist, of the Geotechnical Research Branch, Experimental Engineering Division, un- der the general supervision of Dr...generalized from a detailed vegetation map in the volume Physical Geographic Atlas of the World (Gerasimov 1964), The tundra zone consists mostly of

Division H Commission 33: Structure & Dynamics of the Galactic System

NASA Astrophysics Data System (ADS)

Nordström, Birgitta; Bland-Hawthorn, Joss; Wyse, Rosemary; Athanassoula, Lia; Feltzing, Sofia; Jog, Chanda; Lockman, Jay; Minniti, Dante; Robin, Annie

2016-04-01

Research on the structure and dynamics of the Galactic System covers a large field of research, from formation scenarios to long-term evolution and secular processes. Today we speak of near-field cosmology where the oldest parts of the Galaxy are used to probe back to early times, e.g. studying the chemical signatures of the oldest star clusters and dwarf galaxies to learn about the byproducts of the first stars. Some of the most detailed work relates to the structure of the dark matter and baryons in order to compare with expectation from N-body models. Secular processes have been identified (e.g. stellar migration) where material within the Galaxy is being reorganized by dynamical resonances and feedback processes.

Learning about Cells as Dynamic Entities: An Inquiry-Driven Cell Culture Project

ERIC Educational Resources Information Center

Palombi, Peggy Shadduck; Jagger, Kathleen Snell

2008-01-01

Using cultured fibroblast cells, undergraduate students explore cell division and the responses of cultured cells to a variety of environmental changes. The students learn new research techniques and carry out a self-designed experiment. Through this project, students enhance their creative approach to scientific inquiry, learn time-management and…

The gammaTuRC Nanomachine Mechanism and Future Applications

NASA Astrophysics Data System (ADS)

Riehlman, Timothy D.

The complexity and precision of the eukaryotic cell's cytoskeletal network is unrivaled by any man-made systems, perfected by billions of years of evolution, mastering elegant processes of self-assembly, error correction, and self-repair. Understanding the capabilities of these networks will have important and far reaching applications in human medicine by aiding our understanding of developmental processes, cellular division, and disease mechanisms, and through biomimicry will provide insights for biosynthetic manufacturing at the nanoscale and across scales. My research utilizes cross species techniques from Human to the model organism of Fission Yeast to investigate the structure and mechanisms of the g-tubulin ring complex (gTuRC). The gTuRC is a highly conserved eukaryotic multiprotein complex serving as a microtubule organizing center (MTOC) responsible for microtubule nucleation through templating, regulation of dynamics, and establishment of microtubule polarity. Microtubules are 25 nm diameter dynamic flexible polymers of a/b-tubulin heterodimers that function as scaffolds, force generators, distributors, and intracellular highways. The microtubule cytoskeleton is essential for numerous fundamental cellular processes such as mitotic division of chromosomes and cell division, organelle distribution within the cell, cell signaling, and cell shape. This incredible diversity in functions is made possible in part due to molecular motor Kinesin-like proteins (Klps), which allow expansion into more specialized neural, immune, and ciliated cell functions. Combined, the MTOC, microtubules, and Klps represent ideal microtubule cytoskeleton protein (MCP) modular components for in vitro biomimicry towards generation of adaptable patterned networks for human designed applications. My research investigates the hypothesis that a mechanistic understanding of conserved MTOC gTuRC mechanisms will help us understand dynamic cellular nanomachines and their ability to self-assemble complex structures for applications in biomedicine and new roles in biomimetic nanotechnologies.

Structures and Dynamics Division research and technology plans, FY 1982

NASA Technical Reports Server (NTRS)

Bales, K. S.

1982-01-01

Computational devices to improve efficiency for structural calculations are assessed. The potential of large arrays of microprocessors operating in parallel for finite element analysis is defined, and the impact of specialized computer hardware on static, dynamic, thermal analysis in the optimization of structural analysis and design calculations is determined. General aviation aircraft crashworthiness and occupant survivability is also considered. Mechanics technology required for design coefficient, fault tolerant advanced composite aircraft components subject to combined loads, impact, postbuckling effects and local discontinuities are developed.

Physics Division annual report, 1 January-31 December 1984

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1985-10-01

A brief overview of each of the several areas of research is given with a list of resulting publications. Areas of research include electron-positron annihilation, neutrino interactions, neutrinoless double beta decay of /sup 100/Mo, double beta decay of /sup 76/Ge, antiproton-proton interactions, right-handed gauge boson effects, muon decay asymmetry parameter measurements, supernovae detection, Nemesis search, and detector development. Areas of theoretical research include electroweak interactions, strong interactions, nonperturbative dynamics, supersymmetry, and cosmology and particle physics. 34 figs. (WRF)

Pre-Cancer Atlas (PCA) and Other Human Tumor Atlas Network (HTAN) Funding Opportunity Announcements (FOAs) Released | Division of Cancer Prevention

Cancer.gov

There are 3 new funding opportunity announcements about the Pre-Cancer Atlas associated with the Beau Biden Cancer MoonshotSM Initiative that are intended to accelerate cancer research. The purpose of the FOAs is to promote research that results in a comprehensive view of the dynamic, multidimensional tumor ecosystem and is a direct response to the Moonshot Blue Ribbon Panel

Division by zero, pseudo-division by zero, Zhang dynamics method and Zhang-gradient method about control singularity conquering

NASA Astrophysics Data System (ADS)

Zhang, Yunong; Zhang, Yinyan; Chen, Dechao; Xiao, Zhengli; Yan, Xiaogang

2017-01-01

In this paper, the division-by-zero (DBO) problem in the field of nonlinear control, which is traditionally termed the control singularity problem (or specifically, controller singularity problem), is investigated by the Zhang dynamics (ZD) method and the Zhang-gradient (ZG) method. According to the impact of the DBO problem on the state variables of the controlled nonlinear system, the concepts of the pseudo-DBO problem and the true-DBO problem are proposed in this paper, which provide a new perspective for the researchers on the DBO problems as well as nonlinear control systems. Besides, the two classes of DBO problems are solved under the framework of the ZG method. Specific examples are shown and investigated in this paper to illustrate the two proposed concepts and the efficacy of the ZG method in conquering pseudo-DBO and true-DBO problems. The application of the ZG method to the tracking control of a two-wheeled mobile robot further substantiates the effectiveness of the ZG method. In addition, the ZG method is successfully applied to the tracking control of a pure-feedback nonlinear system.

Parallel Computational Fluid Dynamics: Current Status and Future Requirements

NASA Technical Reports Server (NTRS)

Simon, Horst D.; VanDalsem, William R.; Dagum, Leonardo; Kutler, Paul (Technical Monitor)

1994-01-01

One or the key objectives of the Applied Research Branch in the Numerical Aerodynamic Simulation (NAS) Systems Division at NASA Allies Research Center is the accelerated introduction of highly parallel machines into a full operational environment. In this report we discuss the performance results obtained from the implementation of some computational fluid dynamics (CFD) applications on the Connection Machine CM-2 and the Intel iPSC/860. We summarize some of the experiences made so far with the parallel testbed machines at the NAS Applied Research Branch. Then we discuss the long term computational requirements for accomplishing some of the grand challenge problems in computational aerosciences. We argue that only massively parallel machines will be able to meet these grand challenge requirements, and we outline the computer science and algorithm research challenges ahead.

Automatic speech recognition technology development at ITT Defense Communications Division

NASA Technical Reports Server (NTRS)

White, George M.

1977-01-01

An assessment of the applications of automatic speech recognition to defense communication systems is presented. Future research efforts include investigations into the following areas: (1) dynamic programming; (2) recognition of speech degraded by noise; (3) speaker independent recognition; (4) large vocabulary recognition; (5) word spotting and continuous speech recognition; and (6) isolated word recognition.

Eye-Rollers, Risk-Takers, and Turn Sharks: Target Students in a Professional Science Education Program

ERIC Educational Resources Information Center

Martin, Sonya N.; Milne, Catherine; Scantlebury, Kathryn

2006-01-01

In classrooms from kindergarten to graduate school, researchers have identified target students as students who monopolize material and human resources. Classroom structures that privilege the voice and actions of target students can cause divisive social dynamics that may generate cliques. This study focuses on the emergence of target students,…

Laboratory directed research and development program FY 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-03-01

This report compiles the annual reports of Laboratory Directed Research and Development projects supported by the Berkeley Lab. Projects are arranged under the following topical sections: (1) Accelerator and fusion research division; (2) Chemical sciences division; (3) Computing Sciences; (4) Earth sciences division; (5) Environmental energy technologies division; (6) life sciences division; (7) Materials sciences division; (8) Nuclear science division; (9) Physics division; (10) Structural biology division; and (11) Cross-divisional. A total of 66 projects are summarized.

Surgery on Fetus Reduces Complications of Spina Bifida

MedlinePlus Videos and Cool Tools

... Division of Intramural Research (DIR) Division of Intramural Population Health Research (DIPHR) Research Funded by NICHD Division of ... Research (DIR) Training in the Division of Intramural Population Health Research (DIPHR) Sample Applications Find a Program Officer ...

Behavioral Health and Performance at NASA JSC: Recent Successes and Future Plan for BHP Research and Operations

NASA Technical Reports Server (NTRS)

Leveton, L. B.; VanderArk, S. T.

2014-01-01

The Behavioral Health and Performance discipline at NASA Johnson Space Center is organized into two distinct Divisions (Biomedical Research and Environmental Science Division and Space and Clinical Operations Division) but is integrated and interrelated in its day-to-day work. Ongoing operations supporting NASA's spaceflight goals benefit from the research portfolios that address risks to mission success. Similarly, these research portfolios are informed by operations to ensure investigations stay relevant given the dynamic environment of spaceflight. There are many success stories that can be presented where initial work begun as a BHP Research project, and funded through the Human Research Program, was fully implemented in operations or addressed an operational need. Examples include improving effectiveness of the debriefings used within Mission Control by the Mission Operations Directorate and countermeasures for fatigue management. There is also ongoing collaboration with research and operations for developing selection methods for future generation astronauts, and to enhance and inform the current family support function. The objective of this panel is to provide examples of recent success stories, describe areas where close collaboration is benefitting ongoing research and operations, and summarize how this will come together as NASA plans for the one year ISS mission - a unique opportunity for both BHP operations and research to learn more about preparing and supporting crewmembers for extended missions in space. The proposed panel will be comprised of six presentations, each describing a unique aspect of research or operations and the benefits to current and future spaceflight.

Telepresence master glove controller for dexterous robotic end-effectors

NASA Technical Reports Server (NTRS)

Fisher, Scott S.

1987-01-01

This paper describes recent research in the Aerospace Human Factors Research Division at NASA's Ames Research Center to develop a glove-like, control and data-recording device (DataGlove) that records and transmits to a host computer in real time, and at appropriate resolution, a numeric data-record of a user's hand/finger shape and dynamics. System configuration and performance specifications are detailed, and current research is discussed investigating its applications in operator control of dexterous robotic end-effectors and for use as a human factors research tool in evaluation of operator hand function requirements and performance in other specialized task environments.

Research on Intense Electron Beams and Applications.

DTIC Science & Technology

1983-08-01

lITL IA-y < Tj-2 each figure, the real part of Atp- 1 in centimeters10 A-, > TL,/2’ (5 is plotted versus time in seconds. The resonance condition, Eq...Physics Division, Naval Research Laboratory. S-The report covers the period June 1981 to June 1983, during which time investigations were conducted into...areas: (1) Transverse linear beam dynamics in ’. time varying, azimuthally symmetric fields, (2) Effects of grad B0 induced drifts, (3) Orbital

Electrothermal-Chemical Modeling and Diagnostics Workshop. Volume 1

DTIC Science & Technology

1991-10-01

z ox IOX OLVox 110~ Table 2: Summary of the theorctical rcsuilts (J Powell and Zielinski (ideal plasma) Shot VTr T P.’ 4 Volts (cV) (.Pa) (. m) 2 1221...Gloria P. Wren Ballistic Research Laboratory ATTN: SLCBR-IB-B Aberdeen Proving Ground, MD 21005-5066 (301) 278-6199 Mr. Alex Zielinski Ballistic Research...Park Road, SE Warren, MI 48090-2074 Albuquerque, NM 87106 General Dynamics Land Systems Division 1 Teledyne Brown Engineering ATTN: Dave Toepler ATTN

Parallel realities: exploring poverty dynamics using mixed methods in rural Bangladesh.

PubMed

Davisa, Peter; Baulch, Bob

2011-01-01

This paper explores the implications of using two methodological approaches to study poverty dynamics in rural Bangladesh. Using data from a unique longitudinal study, we show how different methods lead to very different assessments of socio-economic mobility. We suggest five ways of reconciling these differences: considering assets in addition to expenditures, proximity to the poverty line, other aspects of well-being, household division, and qualitative recall errors. Considering assets and proximity to the poverty line along with expenditures resolves three-fifths of the qualitative and quantitative differences. Use of such integrated mixed-methods can therefore improve the reliability of poverty dynamics research.

Computational Fluid Dynamics Symposium on Aeropropulsion

NASA Technical Reports Server (NTRS)

1991-01-01

Recognizing the considerable advances that have been made in computational fluid dynamics, the Internal Fluid Mechanics Division of NASA Lewis Research Center sponsored this symposium with the objective of providing a forum for exchanging information regarding recent developments in numerical methods, physical and chemical modeling, and applications. This conference publication is a compilation of 4 invited and 34 contributed papers presented in six sessions: algorithms one and two, turbomachinery, turbulence, components application, and combustors. Topics include numerical methods, grid generation, chemically reacting flows, turbulence modeling, inlets, nozzles, and unsteady flows.

Microgravity science and applications projects and payloads

NASA Technical Reports Server (NTRS)

Crouch, R. K.

1987-01-01

An overview of work conducted by the Microgravity Science and Applications Division of NASA is presented. The goals of the program are the development and implementation of a reduced-gravity research, science and applications program, exploitation of space for human benefits, and the application of reduced gravity research for the development of advanced technologies. Space research of fluid dynamics and mass transport phenomena is discussed and the facilities available for reduced gravity experiments are presented. A program for improving communication with the science and applications communities and the potential use of the Space Station for microgravity research are also examined.

ARO in Review 2013 Annual Historical Record of the Army Research Laboratory’s Army Research Office (ARO) Programs and Funding Activities

DTIC Science & Technology

2017-06-30

nonlinear dynamics and beyond. J . R. Soc. Interface. 8:107-116. PHYSICS DIVISION CHAPTER 12 ARO IN REVIEW 2013 232 C . Small Business Innovation...goals, management strategies, funding information, and accomplishments Douglas J . Kiserow, Ph.D. Editor Kelby O. Kizer, Ph.D. Editor...component programs (MURI, PECASE, and DURIP). C . Other Funding Sources In addition to the Army- and OSD-funded programs described earlier in this

A minimal model of epithelial tissue dynamics and its application to the corneal epithelium

NASA Astrophysics Data System (ADS)

Henkes, Silke; Matoz-Fernandez, Daniel; Kostanjevec, Kaja; Coburn, Luke; Sknepnek, Rastko; Collinson, J. Martin; Martens, Kirsten

Epithelial cell sheets are characterized by a complex interplay of active drivers, including cell motility, cell division and extrusion. Here we construct a particle-based minimal model tissue with only division/death dynamics and show that it always corresponds to a liquid state with a single dynamic time scale set by the division rate, and that no glassy phase is possible. Building on this, we construct an in-silico model of the mammalian corneal epithelium as such a tissue confined to a hemisphere bordered by the limbal stem cell zone. With added cell motility dynamics we are able to explain the steady-state spiral migration on the cornea, including the central vortex defect, and quantitatively compare it to eyes obtained from mice that are X-inactivation mosaic for LacZ.

Computational and analytical methods in nonlinear fluid dynamics

NASA Astrophysics Data System (ADS)

Walker, James

1993-09-01

The central focus of the program was on the application and development of modern analytical and computational methods to the solution of nonlinear problems in fluid dynamics and reactive gas dynamics. The research was carried out within the Division of Engineering Mathematics in the Department of Mechanical Engineering and Mechanics and principally involved Professors P.A. Blythe, E. Varley and J.D.A. Walker. In addition. the program involved various international collaborations. Professor Blythe completed work on reactive gas dynamics with Professor D. Crighton FRS of Cambridge University in the United Kingdom. Professor Walker and his students carried out joint work with Professor F.T. Smith, of University College London, on various problems in unsteady flow and turbulent boundary layers.

The role of model organisms in the history of mitosis research.

PubMed

Yanagida, Mitsuhiro

2014-09-02

Mitosis is a cell-cycle stage during which condensed chromosomes migrate to the middle of the cell and segregate into two daughter nuclei before cytokinesis (cell division) with the aid of a dynamic mitotic spindle. The history of mitosis research is quite long, commencing well before the discovery of DNA as the repository of genetic information. However, great and rapid progress has been made since the introduction of recombinant DNA technology and discovery of universal cell-cycle control. A large number of conserved eukaryotic genes required for the progression from early to late mitotic stages have been discovered, confirming that DNA replication and mitosis are the two main events in the cell-division cycle. In this article, a historical overview of mitosis is given, emphasizing the importance of diverse model organisms that have been used to solve fundamental questions about mitosis. Copyright © 2014 Cold Spring Harbor Laboratory Press; all rights reserved.

The Role of Model Organisms in the History of Mitosis Research

PubMed Central

Yanagida, Mitsuhiro

2014-01-01

Mitosis is a cell-cycle stage during which condensed chromosomes migrate to the middle of the cell and segregate into two daughter nuclei before cytokinesis (cell division) with the aid of a dynamic mitotic spindle. The history of mitosis research is quite long, commencing well before the discovery of DNA as the repository of genetic information. However, great and rapid progress has been made since the introduction of recombinant DNA technology and discovery of universal cell-cycle control. A large number of conserved eukaryotic genes required for the progression from early to late mitotic stages have been discovered, confirming that DNA replication and mitosis are the two main events in the cell-division cycle. In this article, a historical overview of mitosis is given, emphasizing the importance of diverse model organisms that have been used to solve fundamental questions about mitosis. PMID:25183827

Performance analysis of Integrated Communication and Control System networks

NASA Technical Reports Server (NTRS)

Halevi, Y.; Ray, A.

1990-01-01

This paper presents statistical analysis of delays in Integrated Communication and Control System (ICCS) networks that are based on asynchronous time-division multiplexing. The models are obtained in closed form for analyzing control systems with randomly varying delays. The results of this research are applicable to ICCS design for complex dynamical processes like advanced aircraft and spacecraft, autonomous manufacturing plants, and chemical and processing plants.

Helicopter Dynamic Performance Program. Volume 2. User’s Manual

DTIC Science & Technology

1980-07-01

Technologies Corporation Stratford, Connecticut 06602 July 1980 Final Report / • ., . Approved for public release; I distribution unlimited. ; A - Prepared...for : APPLIED TECHNOLOGY LABORATORY U. S. ARMY RESEARCH AND TECHNOLOGY LABORATORIES (AVRADCOM) Fort Eustis, Va. 23604 80 8 27 D APPLIED TECHNOLOGY ... Technology Division. Technic31 review of this report was also pro- vided by Messrs. W_ A. Pleasants of Design Integration and Analysis Technical Area

Bridging the Timescales of Single-Cell and Population Dynamics

NASA Astrophysics Data System (ADS)

Jafarpour, Farshid; Wright, Charles S.; Gudjonson, Herman; Riebling, Jedidiah; Dawson, Emma; Lo, Klevin; Fiebig, Aretha; Crosson, Sean; Dinner, Aaron R.; Iyer-Biswas, Srividya

2018-04-01

How are granular details of stochastic growth and division of individual cells reflected in smooth deterministic growth of population numbers? We provide an integrated, multiscale perspective of microbial growth dynamics by formulating a data-validated theoretical framework that accounts for observables at both single-cell and population scales. We derive exact analytical complete time-dependent solutions to cell-age distributions and population growth rates as functionals of the underlying interdivision time distributions, for symmetric and asymmetric cell division. These results provide insights into the surprising implications of stochastic single-cell dynamics for population growth. Using our results for asymmetric division, we deduce the time to transition from the reproductively quiescent (swarmer) to the replication-competent (stalked) stage of the Caulobacter crescentus life cycle. Remarkably, population numbers can spontaneously oscillate with time. We elucidate the physics leading to these population oscillations. For C. crescentus cells, we show that a simple measurement of the population growth rate, for a given growth condition, is sufficient to characterize the condition-specific cellular unit of time and, thus, yields the mean (single-cell) growth and division timescales, fluctuations in cell division times, the cell-age distribution, and the quiescence timescale.

Physics division. Progress report, January 1, 1995--December 31, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stewart, M.; Bacon, D.S.; Aine, C.J.

1997-10-01

This issue of the Physics Division Progress Report describes progress and achievements in Physics Division research during the period January 1, 1995-December 31, 1996. The report covers the five main areas of experimental research and development in which Physics Division serves the needs of Los Alamos National Laboratory and the nation in applied and basic sciences: (1) biophysics, (2) hydrodynamic physics, (3) neutron science and technology, (4) plasma physics, and (5) subatomic physics. Included in this report are a message from the Division Director, the Physics Division mission statement, an organizational chart, descriptions of the research areas of the fivemore » groups in the Division, selected research highlights, project descriptions, the Division staffing and funding levels for FY95-FY97, and a list of publications and presentations.« less

EPA/OFFICE OF RESEARCH AND DEVELOPMENT'S NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY/WESTERN ECOLOGY DIVISION INTERNET SITE

EPA Science Inventory

The Western Ecology Division (WED) is one of four ecological effects divisions of the National Health and Environmental Effects Research Laboratory. The four divisions are distributed bio-geographically. WED's mission is 1) to provide EPA with national scientific leadership for t...

Digital holographic microscopy long-term and real-time monitoring of cell division and changes under simulated zero gravity.

PubMed

Pan, Feng; Liu, Shuo; Wang, Zhe; Shang, Peng; Xiao, Wen

2012-05-07

The long-term and real-time monitoring the cell division and changes of osteoblasts under simulated zero gravity condition were succeed by combing a digital holographic microscopy (DHM) with a superconducting magnet (SM). The SM could generate different magnetic force fields in a cylindrical cavity, where the gravitational force of biological samples could be canceled at a special gravity position by a high magnetic force. Therefore the specimens were levitated and in a simulated zero gravity environment. The DHM was modified to fit with SM by using single mode optical fibers and a vertically-configured jig designed to hold specimens and integrate optical device in the magnet's bore. The results presented the first-phase images of living cells undergoing dynamic divisions and changes under simulated zero gravity environment for a period of 10 hours. The experiments demonstrated that the SM-compatible DHM setup could provide a highly efficient and versatile method for research on the effects of microgravity on biological samples.

Overview of Unsteady Transonic Wind Tunnel Test on a Semispan Straked Delta Wing Oscillating in Pitch

DTIC Science & Technology

1994-08-01

of research between the Lockheed Fort Worth Company (LFWC), Fort Worth, Texas, USA (Formerly the Fort Worth Division of General Dynamics until 28...Separation," NASA CR 4090, August 1987. 13. Cunningham, A.M., Jr. and Bushlow: "Steady and Unsteady Force Testing of Fighter Aircraft Models in a Water Tunnel," AIAA Papaer No. AIAA-90-2815, August 1990. 47

Surveys of research in the Chemistry Division, Argonne National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grazis, B.M.

1992-01-01

Research reports are presented on reactive intermediates in condensed phase (radiation chemistry, photochemistry), electron transfer and energy conversion, photosynthesis and solar energy conversion, metal cluster chemistry, chemical dynamics in gas phase, photoionization-photoelectrons, characterization and reactivity of coal and coal macerals, premium coal sample program, chemical separations, heavy elements coordination chemistry, heavy elements photophysics/photochemistry, f-electron interactions, radiation chemistry of high-level wastes (gas generation in waste tanks), ultrafast molecular electronic devices, and nuclear medicine. Separate abstracts have been prepared. Accelerator activites and computer system/network services are also reported.

Surveys of research in the Chemistry Division, Argonne National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grazis, B.M.

1992-11-01

Research reports are presented on reactive intermediates in condensed phase (radiation chemistry, photochemistry), electron transfer and energy conversion, photosynthesis and solar energy conversion, metal cluster chemistry, chemical dynamics in gas phase, photoionization-photoelectrons, characterization and reactivity of coal and coal macerals, premium coal sample program, chemical separations, heavy elements coordination chemistry, heavy elements photophysics/photochemistry, f-electron interactions, radiation chemistry of high-level wastes (gas generation in waste tanks), ultrafast molecular electronic devices, and nuclear medicine. Separate abstracts have been prepared. Accelerator activites and computer system/network services are also reported.

Loads and aeroelasticity division research and technology accomplishments for FY 1983 and plans for FY 1984

NASA Technical Reports Server (NTRS)

Gardner, J. E.; Dixon, S. C.

1984-01-01

Research was done in the following areas: development and validation of solution algorithms, modeling techniques, integrated finite elements for flow-thermal-structural analysis and design, optimization of aircraft and spacecraft for the best performance, reduction of loads and increase in the dynamic structural stability of flexible airframes by the use of active control, methods for predicting steady and unsteady aerodynamic loads and aeroelastic characteristics of flight vehicles with emphasis on the transonic range, and methods for predicting and reducing helicoper vibrations.

Long-term, high-resolution confocal time lapse imaging of Arabidopsis cotyledon epidermis during germination.

PubMed

Peterson, Kylee M; Torii, Keiko U

2012-12-31

Imaging in vivo dynamics of cellular behavior throughout a developmental sequence can be a powerful technique for understanding the mechanics of tissue patterning. During animal development, key cell proliferation and patterning events occur very quickly. For instance, in Caenorhabditis elegans all cell divisions required for the larval body plan are completed within six hours after fertilization, with seven mitotic cycles(1); the sixteen or more mitoses of Drosophila embryogenesis occur in less than 24 hr(2). In contrast, cell divisions during plant development are slow, typically on the order of a day (3,4,5) . This imposes a unique challenge and a need for long-term live imaging for documenting dynamic behaviors of cell division and differentiation events during plant organogenesis. Arabidopsis epidermis is an excellent model system for investigating signaling, cell fate, and development in plants. In the cotyledon, this tissue consists of air- and water-resistant pavement cells interspersed with evenly distributed stomata, valves that open and close to control gas exchange and water loss. Proper spacing of these stomata is critical to their function, and their development follows a sequence of asymmetric division and cell differentiation steps to produce the organized epidermis (Fig. 1). This protocol allows observation of cells and proteins in the epidermis over several days of development. This time frame enables precise documentation of stem-cell divisions and differentiation of epidermal cells, including stomata and epidermal pavement cells. Fluorescent proteins can be fused to proteins of interest to assess their dynamics during cell division and differentiation processes. This technique allows us to understand the localization of a novel protein, POLAR(6), during the proliferation stage of stomatal-lineage cells in the Arabidopsis cotyledon epidermis, where it is expressed in cells preceding asymmetric division events and moves to a characteristic area of the cell cortex shortly before division occurs. Images can be registered and streamlined video easily produced using public domain software to visualize dynamic protein localization and cell types as they change over time.

Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures

PubMed Central

Cerruti, Benedetta; Puliafito, Alberto; Shewan, Annette M.; Yu, Wei; Combes, Alexander N.; Little, Melissa H.; Chianale, Federica; Primo, Luca; Serini, Guido; Mostov, Keith E.; Celani, Antonio

2013-01-01

The growth of a well-formed epithelial structure is governed by mechanical constraints, cellular apico-basal polarity, and spatially controlled cell division. Here we compared the predictions of a mathematical model of epithelial growth with the morphological analysis of 3D epithelial structures. In both in vitro cyst models and in developing epithelial structures in vivo, epithelial growth could take place close to or far from mechanical equilibrium, and was determined by the hierarchy of time-scales of cell division, cell–cell rearrangements, and lumen dynamics. Equilibrium properties could be inferred by the analysis of cell–cell contact topologies, and the nonequilibrium phenotype was altered by inhibiting ROCK activity. The occurrence of an aberrant multilumen phenotype was linked to fast nonequilibrium growth, even when geometric control of cell division was correctly enforced. We predicted and verified experimentally that slowing down cell division partially rescued a multilumen phenotype induced by altered polarity. These results improve our understanding of the development of epithelial organs and, ultimately, of carcinogenesis. PMID:24145168

CONFERENCES AND SYMPOSIA Commemoration of the 85th birthday of S I Syrovatskii(Scientific session of the Physical Sciences Division of the Russian Academy of Sciences, 26 May 2010)

NASA Astrophysics Data System (ADS)

2010-12-01

A scientific session of the Physical Sciences Division, Russian Academy of Sciences (RAS), was held on 26 May 2010 at the conference hall of the Lebedev Physical Institute, RAS. The session was devoted to the 85th birthday of S I Syrovatskii. The program announced on the web page of the RAS Physical Sciences Division (www.gpad.ac.ru) contained the following reports: (1) Zelenyi L M (Space Research Institute, RAS, Moscow) "Current sheets and reconnection in the geomagnetic tail"; (2) Frank A G (Prokhorov General Physics Institute, RAS, Moscow) "Dynamics of current sheets as the cause of flare events in magnetized plasmas"; (3) Kuznetsov V D (Pushkov Institute of Terrestrial Magnetism, the Ionosphere, and Radio Wave Propagation, RAS, Troitsk, Moscow region) "Space research on the Sun"; (4) Somov B V (Shternberg Astronomical Institute, Lomonosov Moscow State University, Moscow) "Strong shock waves and extreme plasma states"; (5) Zybin K P (Lebedev Physical Institute, RAS, Moscow) "Structure functions for developed turbulence"; (6) Ptuskin V S (Pushkov Institute of Terrestrial Magnetism, the Ionosphere, and Radio Wave Propagation, RAS, Troitsk, Moscow region) "The origin of cosmic rays." Papers based on reports 1-4 and 6 are published in what follows. • Metastability of current sheets, L M Zelenyi, A V Artemyev, Kh V Malova, A A Petrukovich, R Nakamura Physics-Uspekhi, 2010, Volume 53, Number 9, Pages 933-941 • Dynamics of current sheets underlying flare-type events in magnetized plasmas, A G Frank Physics-Uspekhi, 2010, Volume 53, Number 9, Pages 941-947 • Space research of the Sun, V D Kuznetsov Physics-Uspekhi, 2010, Volume 53, Number 9, Pages 947-954 • Magnetic reconnection in solar flares, B V Somov Physics-Uspekhi, 2010, Volume 53, Number 9, Pages 954-958 • The origin of cosmic rays, V S Ptuskin Physics-Uspekhi, 2010, Volume 53, Number 9, Pages 958-961

Directory of AFRL/HEA Technical Publications Submitted to DTIC from 1969 to 2007

DTIC Science & Technology

2007-09-01

Research Division ( AFRL /HEA) 2004 to 30 September 1007 – Air Force Research Laboratory , Warfighter Readiness Research Division ( AFRL /HEA...NUMBER 2003 AIR FORCE RESEARCH LABORATORY WARFIGHTER TRAINING RESEARCH DIVISION ( AFRL /HEA) TECHNICAL DOCUMENTS AUTHOR(S) AFRL -HE-AZ-TP-2003...NUMBER WORK UNIT NUMBER 2002 AIR FORCE RESEARCH

Celebrating 65 Years of a Dynamic Organization for School Librarians

ERIC Educational Resources Information Center

Woolls, Blanche

2016-01-01

The American Association of School Librarians (AASL) as an American Library Association division is sixty-five years young in 2016. This article describes the AASL as a division of the American Library Association (ALA). The author presents: (1) Early Days in ALA; (2) AASL as a Division; (3) AASL's Future; and (4) Commemorating the Past by Paying…

Molecular System for the Division of Self-Propelled Oil Droplets by Component Feeding.

PubMed

Banno, Taisuke; Toyota, Taro

2015-06-30

Unique dynamics using inanimate molecular assemblies have drawn a great amount of attention for demonstrating prebiomimetic molecular systems. For the construction of an organized logic combining two fundamental dynamics of life, we demonstrate here a molecular system that exhibits both division and self-propelled motion using oil droplets. The key molecule of this molecular system is a novel cationic surfactant containing a five-membered acetal moiety, and the molecular system can feed the self-propelled oil droplet composed of a benzaldehyde derivative and an alkanol. The division dynamics of the self-propelled oil droplets were observed through the hydrolysis of the cationic surfactant in bulk solution. The mechanism of the current dynamics is argued to be based on the supply of "fresh" oil components in the moving oil droplets, which is induced by the Marangoni instability. We consider this molecular system to be a prototype of self-reproducing inanimate molecular assembly exhibiting self-propelled motion.

[Demographic growth and the dynamics of specialization in the Third World].

PubMed

Coussy, J

1983-01-01

All inquiries into the relationship between demographic growth and specialization in the 3rd World face a conflict found in the entire demographic-economic literature between 2 extreme positions that regard underdevelopment as caused either by the exploitation of developing by developed nations or as caused by overpopulation. This polarization of viewpoints appears to have deflected attention from more productive work and to have retarded empirical research. The object of the present study is to present a systematic and detailed critique of the opposing theoretical positions as a step in moving the debate into more productive areas. The section on the demographic explanation of the dynamics of specialization in developing countries considers its view of the comparative advantages and disadvantages created by demographic growth, including the impact of demographic growth on the availability of factors of production and on the structures of supply, demand, and exchange. The section discussing explanations of demographic-economic disequilibria in the 3rd World that are founded on the international division of labor describes the theory and its view of the division of labor in developing countries including such characteristics as the preponderance of the primary sector, the disproportionate attention to cash crops and relative neglect of subsistence crops, the importation of luxury goods, and the lack of local industrial production; the hypothesis that demographic growth and economic backwardness in developing countries both result from the international divisions of labor; the role of 3rd world demographic-economic disequilibrium in the continuation of the international division of labor; the possible advantages of demographic growth in stimulating supply, demand, and technological progress; and the increased probability of terminating the present international division of labor because of demographic pressure. The article ends with a general critique of the structures of the 2 theories. Despite their apparent simplicity, both extremes must resort to highly complicated formulations and selection of variables, consequently greatly reducing their own explanatory utility.

Industrial Technology Modernization Program. Project 28. Automation of Receiving, Receiving Inspection and Stores

DTIC Science & Technology

1987-06-15

001 GENERAL DYNAMICS 00 FORT WORTH DIVISION INDUSTRIAL TECHNOLOGY MODERNIZATION PROGRAM Phase 2 Final Project Repc t JUNG 0 ?7 PROJECT 28 AUTOMATION...DYNAMICS FORT WORTH DIVISION INDUSTRIAL TECHNOLOGY MODERNIZATION PROGRAM Phase 2 Final Project Report PROJECT 28 AUTOMATION OF RECEIVING, RECEIVING...13 6 PROJECT ASSUMPTIONS 20 7 PRELIMINARY/FINAL DESIGN AND FINDINGS 21 8 SYSTEM/EQUIPMENT/MACHINING SPECIFICATIONS 37 9 VENDOR/ INDUSTRY ANALYSIS

76 FR 75825 - Streamlining Inherited Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-05

... submitting comments. Mail: Research, Markets & Regulations Division, Bureau of Consumer Financial Protection... Lieu of Mail: Research, Markets & Regulations Division, Bureau of Consumer Financial Protection, 1700 G..., Counsel, Research, Markets & Regulations Division, Bureau of Consumer Financial Protection, (202) 453-7700...

NASA LeRC's Acoustic Fill Effect Test Program and Results

NASA Technical Reports Server (NTRS)

Hughes, William O.; Mcnelis, Mark E.; Manning, Jerome E.

1994-01-01

NASA Lewis Research Center, in conjunction with General Dynamics Space Systems Division, has performed a test program to investigate the acoustic fill effect for an unblanketed payload fairing for a variety of payload simulators. This paper will discuss this test program and fill factor test data, and make comparisons with theoretical predictions. This paper will also address the NASA acoustic fill effect standard which was verified from the test data analysis.

Time to Stabilization of Anterior Cruciate Ligament–Reconstructed Versus Healthy Knees in National Collegiate Athletic Association Division I Female Athletes

PubMed Central

Webster, Kathryn A.; Gribble, Phillip A.

2010-01-01

Abstract Context: Jump landing is a common activity in collegiate activities, such as women's basketball, volleyball, and soccer, and is a common mechanism for anterior cruciate ligament (ACL) injury. It is important to better understand how athletes returning to competition after ACL reconstruction are able to maintain dynamic postural control during a jump landing. Objective: To use time to stabilization (TTS) to measure differences in dynamic postural control during jump landing in ACL-reconstructed (ACLR) knees compared with healthy knees among National Collegiate Athletic Association Division I female athletes. Design: Case-control study. Setting: University athletic training research laboratory. Patients or Other Participants: Twenty-four Division I female basketball, volleyball, and soccer players volunteered and were assigned to the healthy control group (n  =  12) or the ACLR knee group (n  =  12). Participants with ACLR knees were matched to participants with healthy knees by sport and by similar age, height, and mass. Intervention(s): At 1 session, participants performed a single-leg landing task for both limbs. They were instructed to stabilize as quickly as possible in a single-limb stance and remain as motionless as possible for 10 seconds. Main Outcome Measure(s): The anterior-posterior TTS and medial-lateral TTS ground reaction force data were used to calculate resultant vector of the TTS (RVTTS) during a jump landing. A 1-way analysis of variance was used to determine group differences on RVTTS. The means and SDs from the participants' 10 trials in each leg were used for the analyses. Results: The ACLR group (2.01 ± 0.15 seconds, 95% confidence interval [CI]  =  1.91, 2.10) took longer to stabilize than the control group (1.90 ± 0.07 seconds, 95% CI  =  1.86, 1.95) (F1,22  =  4.28, P  =  .05). This result was associated with a large effect size and a 95% CI that did not cross zero (Cohen d  =  1.0, 95% CI  =  0.91, 1.09). Conclusions: Although they were Division I female athletes at an average of 2.5 years after ACL reconstruction, participants with ACLR knees demonstrated dynamic postural-control deficits as evidenced by their difficulty in controlling ground reaction forces. This increased TTS measurement might contribute to the established literature reflecting differences in single-limb dynamic control. Clinicians might need to focus rehabilitation efforts on stabilization after jump landing. Further research is needed to determine if TTS is a contributing factor in future injury. PMID:21062181

Engineering physics and mathematics division

NASA Astrophysics Data System (ADS)

Sincovec, R. F.

1995-07-01

This report provides a record of the research activities of the Engineering Physics and Mathematics Division for the period 1 Jan. 1993 - 31 Dec. 1994. This report is the final archival record of the EPM Division. On 1 Oct. 1994, ORELA was transferred to Physics Division and on 1 Jan. 1995, the Engineering Physics and Mathematics Division and the Computer Applications Division reorganized to form the Computer Science and Mathematics Division and the Computational Physics and Engineering Division. Earlier reports in this series are identified on the previous pages, along with the progress reports describing ORNL's research in the mathematical sciences prior to 1984 when those activities moved into the Engineering Physics and Mathematics Division.

Overview of the Applied Aerodynamics Division

NASA Technical Reports Server (NTRS)

1991-01-01

A major reorganization of the Aeronautics Directorate of the Langley Research Center occurred in early 1989. As a result of this reorganization, the scope of research in the Applied Aeronautics Division is now quite different than that in the past. An overview of the current organization, mission, and facilities of this division is presented. A summary of current research programs and sample highlights of recent research are also presented. This is intended to provide a general view of the scope and capabilities of the division.

Space human factors publications: 1980-1990

NASA Technical Reports Server (NTRS)

Dickson, Katherine J.

1991-01-01

A 10 year cummulative bibliography of publications resulting from research supported by the NASA Space Human Factors Program of the Life Science Division is provided. The goal of this program is to understand the basic mechanisms underlying behavioral adaptation to space and to develop and validate system design requirements, protocols, and countermeasures to ensure the psychological well-being, safety, and productivity of crewmembers. Subjects encompassed by this bibliography include selection and training, group dynamics, psychophysiological interactions, habitability issues, human-machine interactions, psychological support measures, and anthropometric data. Principal Investigators whose research tasks resulted in publication are identified by asterisk.

The finite state projection approach to analyze dynamics of heterogeneous populations

NASA Astrophysics Data System (ADS)

Johnson, Rob; Munsky, Brian

2017-06-01

Population modeling aims to capture and predict the dynamics of cell populations in constant or fluctuating environments. At the elementary level, population growth proceeds through sequential divisions of individual cells. Due to stochastic effects, populations of cells are inherently heterogeneous in phenotype, and some phenotypic variables have an effect on division or survival rates, as can be seen in partial drug resistance. Therefore, when modeling population dynamics where the control of growth and division is phenotype dependent, the corresponding model must take account of the underlying cellular heterogeneity. The finite state projection (FSP) approach has often been used to analyze the statistics of independent cells. Here, we extend the FSP analysis to explore the coupling of cell dynamics and biomolecule dynamics within a population. This extension allows a general framework with which to model the state occupations of a heterogeneous, isogenic population of dividing and expiring cells. The method is demonstrated with a simple model of cell-cycle progression, which we use to explore possible dynamics of drug resistance phenotypes in dividing cells. We use this method to show how stochastic single-cell behaviors affect population level efficacy of drug treatments, and we illustrate how slight modifications to treatment regimens may have dramatic effects on drug efficacy.

Two-Dimensional, Time-Dependent Plasma Structures of a Hall Effect Thruster

DTIC Science & Technology

2011-09-01

atmospheric pressure to 80 mtorr, is accomplished by a Leybold-Trivac rotary van vacuum pump and the second stage is completed by four 20 in CVI...Thruster”. Physics of Plasmas, 13, 2006. 3. Albarede, Luc, Vanessa Vial, Alexey Lazurenko, Andre Bouchoule, and Michel Dudeck. “Low Frequency Dynamical...Force Research Laboratory Space and Missile Division (AFRL/RZS) 5 Pollux Drive Edwards AFB, CA 93524 DSN 525-5230 AFRL/RZS Approval for public release

Simulation of Thrust-Vectored Aircraft Maneuvers on a Human Centrifuge: Model Validation and Design for the Dynamic Environment Simulator

DTIC Science & Technology

1998-09-01

reviewed and is approved for publication. FOR THE DIRECTOR ROGER L. STORK , Colonel, USAF, BSC Chief, Biodynamics and Protection Division Air Force Research...possible disorienting stimuli. Short radius yaw rotational movements that occur in helicopter flight and vertical take off and landing (VTOL) fixed wing ... wing flight. Aeronautical terms and thought has evolved. Tactical concepts, once thought inviolate, are changing. New terms are emerging and the very

Industrial Technology Modernization Program. Project 20. Consolidation and Automation of Material and Tool Storage. Phase 2

DTIC Science & Technology

1987-06-15

GENERAL DYNAMICS FORT WORTH DIVISION INDUSTRIAL TECHNOLOGY00 N MODERNIZATION PROGRAM Phase 2 Final Project Report DT C JUNO 7 1989J1K PROJECT 20...CLASSIFICATION O THIS PAGE All other editions are obsolete. unclassified Honeywell JUNE 15, 1987 GENERAL DYNAMICS FORT WORTH DIVISION INDUSTRIAL ...SYSTEMIEQUIPMENT/MACHINING SPECIFICATIONS 33 9 VENDOR/ INDUSTRY ANALYSIS FINDING 39 10 MIS REQUIREMENTS/IMPROVEMENTS 45 11 COST BENEFIT ANALYSIS 48 12 IMPLEMENTATION

75 FR 16353 - Revision of Organization and Conforming Changes to Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-01

... History Office. CENTER FOR BIOLOGICS EVALUATION AND RESEARCH.\\9\\ \\9\\ Mailing address: 1401 Rockville Pike.... Office of Blood Research and Review. Policy and Publications Staff. Division of Emerging and Transfusion Transmitted Diseases. Division of Hematology. Division of Blood Applications. Office of Vaccines Research and...

A Balancing Act: Division III Student-Athletes Time Demands and Life Roles

ERIC Educational Resources Information Center

Hoover, Daniel R., Jr.

2012-01-01

A majority of the research on student-athletes occurs at the Division I level, acid less is known about Division III student-athletes. The scant research addressing the experiences of Division III students-athletes focused on academics, campus involvement, development, and athletic identity (Griffith & Johnson, 2002; Heuser & Gray, 2009;…

Research Networks Map | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention supports major scientific collaborations and research networks at more than 100 sites across the United States. Seven Major Programs' sites are shown on this map. | The Division of Cancer Prevention supports major scientific collaborations and research networks at more than 100 sites across the United States.

Cognitive and Neural Sciences Division 1990 Programs.

ERIC Educational Resources Information Center

Vaughan, Willard S., Jr., Ed.

Research and development efforts carried out under sponsorship of the Cognitive and Neural Sciences Division of the Office of Naval Research during fiscal year 1990 are described in this compilation of project description summaries. The Division's research is organized in three types of programs: (1) Cognitive Science (the human learner--cognitive…

Biology Division progress report, October 1, 1993--September 30, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-10-01

This Progress Report summarizes the research endeavors of the Biology Division of the Oak Ridge National Laboratory during the period October 1, 1993, through September 30, 1995. The report is structured to provide descriptions of current activities and accomplishments in each of the Division`s major organizational units. Lists of information to convey the entire scope of the Division`s activities are compiled at the end of the report. Attention is focused on the following research activities: molecular, cellular, and cancer biology; mammalian genetics and development; genome mapping program; and educational activities.

Environmental Assessment for Air Force Research Laboratory Space Vehicles Integrated Experiments Division Office Space at Kirtland Air Force Base, Albuquerque, New Mexico

DTIC Science & Technology

2005-06-01

AIR FORCE RESEARCH LABORATORY SPACE VEHICLES INTEGRATED EXPERMENTS DIVISION OFFICE SPACE AT KIRTLAND AIR FORCE ... Kirtland Air Force Base (KAFB). The office building would house the Air Force Research Laboratory Space Vehicles Integrated Experiments Division...ADDRESS(ES) Air Force Research Laboratory ,Space Vehicles Directorate,3550 Aberdeen Ave. SE, Kirtland

Diet and Cancer Prevention: Chewing on the Human Complexities | Division of Cancer Prevention

Cancer.gov

Speaker Johanna W. Lampe, PhD, RD Research Professor University of Washington Full Member and Associate Division Director Cancer Prevention Program Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle, WA |

About DCP | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) is the division of the National Cancer Institute (NCI) devoted to cancer prevention research. DCP provides funding and administrative support to clinical and laboratory researchers, community and multidisciplinary teams, and collaborative scientific networks. |

76 FR 21256 - Proposed Assessment Rate Adjustment Guidelines for Large and Highly Complex Institutions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-15

... CONTACT: Lisa Ryu, Chief, Large Bank Pricing Section, Division of Insurance and Research, (202) 898-3538; Andrew Felton, Acting Chief, Large Bank Pricing Section, Division of Insurance and Research, (202) 898-3823; Mike Anas, Senior Financial Analyst, Division of Insurance and Research, (630) 241-0359 x 8252...

Sixth Annual NASA Ames Space Science and Astrobiology Jamboree

NASA Technical Reports Server (NTRS)

Hollingsworth, Jeffery; Howell, Steve; Fonda, Mark; Dateo, Chris; Martinez, Christine M.

2018-01-01

Welcome to the Sixth Annual NASA Ames Research Center, Space Science and Astrobiology Jamboree at NASA Ames Research Center (ARC). The Space Science and Astrobiology Division consists of over 60 Civil Servants, with more than 120 Cooperative Agreement Research Scientists, Post-Doctoral Fellows, Science Support Contractors, Visiting Scientists, and many other Research Associates. Within the Division there is engagement in scientific investigations over a breadth of disciplines including Astrobiology, Astrophysics, Exobiology, Exoplanets, Planetary Systems Science, and many more. The Division's personnel support NASA spacecraft missions (current and planned), including SOFIA, K2, MSL, New Horizons, JWST, WFIRST, and others. Our top-notch science research staff is spread amongst three branches in five buildings at ARC. Naturally, it can thus be difficult to remain abreast of what fellow scientific researchers pursue actively, and then what may present and/or offer regarding inter-Branch, intra-Division future collaborative efforts. In organizing this annual jamboree, the goals are to offer a wholesome, one-venue opportunity to sense the active scientific research and spacecraft mission involvement within the Division; and to facilitate communication and collaboration amongst our research scientists. Annually, the Division honors one senior research scientist with a Pollack Lecture, and one early career research scientist with an Outstanding Early Career Space Scientist Lecture. For the Pollack Lecture, the honor is bestowed upon a senior researcher who has made significant contributions within any area of research aligned with space science and/or astrobiology. This year we are pleased to honor Linda Jahnke. With the Early Career Lecture, the honor is bestowed upon an early-career researcher who has substantially demonstrated great promise for significant contributions within space science, astrobiology, and/or, in support of spacecraft missions addressing such disciplines. This year we are pleased to honor Amanda Cook. We hope that you will make time to join us for the day in meeting fellow Division members, expanding knowledge of our activities, and creating new collaborations within the Space Science and Astrobiology Division.

Division rate, cell size and proteome allocation: impact on gene expression noise and implications for the dynamics of genetic circuits

PubMed Central

2018-01-01

The cell division rate, size and gene expression programmes change in response to external conditions. These global changes impact on average concentrations of biomolecule and their variability or noise. Gene expression is inherently stochastic, and noise levels of individual proteins depend on synthesis and degradation rates as well as on cell-cycle dynamics. We have modelled stochastic gene expression inside growing and dividing cells to study the effect of division rates on noise in mRNA and protein expression. We use assumptions and parameters relevant to Escherichia coli, for which abundant quantitative data are available. We find that coupling of transcription, but not translation rates to the rate of cell division can result in protein concentration and noise homeostasis across conditions. Interestingly, we find that the increased cell size at fast division rates, observed in E. coli and other unicellular organisms, buffers noise levels even for proteins with decreased expression at faster growth. We then investigate the functional importance of these regulations using gene regulatory networks that exhibit bi-stability and oscillations. We find that network topology affects robustness to changes in division rate in complex and unexpected ways. In particular, a simple model of persistence, based on global physiological feedback, predicts increased proportion of persister cells at slow division rates. Altogether, our study reveals how cell size regulation in response to cell division rate could help controlling gene expression noise. It also highlights that understanding circuits' robustness across growth conditions is key for the effective design of synthetic biological systems. PMID:29657814

Solid State Division progress report for period ending March 31, 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, P.H.; Hinton, L.W.

1997-12-01

This report covers research progress in the Solid State Division from April 1, 1995, through March 31, 1997. During this period, the division conducted a broad, interdisciplinary materials research program in support of Department of Energy science and technology missions. The report includes brief summaries of research activities in condensed matter theory, neutron scattering, synthesis and characterization of materials, ion beam and laser processing, and the structure of solids and surfaces. An addendum includes listings of division publications and professional activities.

Argonne Discovery Yields Self-Healing Diamond-Like Carbon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cunningham, Greg; Jones, Katie Elyce

We report that large-scale reactive molecular dynamics simulations carried out on the US Department of Energy’s IBM Blue Gene/Q Mira supercomputer at the Argonne Leadership Computing Facility, along with experiments conducted by researchers in Argonne’s Energy Systems Division, enabled the design of a “self-healing” anti-wear coating that drastically reduces friction and related degradation in engines and moving machinery. Now, the computational work advanced for this purpose is being used to identify the friction-fighting potential of other catalysts.

Argonne Discovery Yields Self-Healing Diamond-Like Carbon

DOE PAGES

Cunningham, Greg; Jones, Katie Elyce

2016-10-27

We report that large-scale reactive molecular dynamics simulations carried out on the US Department of Energy’s IBM Blue Gene/Q Mira supercomputer at the Argonne Leadership Computing Facility, along with experiments conducted by researchers in Argonne’s Energy Systems Division, enabled the design of a “self-healing” anti-wear coating that drastically reduces friction and related degradation in engines and moving machinery. Now, the computational work advanced for this purpose is being used to identify the friction-fighting potential of other catalysts.

Engineering Research Division publication report, calendar year 1980

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, E.K.; Livingston, P.L.; Rae, D.C.

Each year the Engineering Research Division of the Electronics Engineering Department at Lawrence Livermore Laboratory has issued an internal report listing all formal publications produced by the Division during the calendar year. Abstracts of 1980 reports are presented.

Atmospheric Research 2014 Technical Highlights

NASA Technical Reports Server (NTRS)

Platnick, Steven

2015-01-01

Atmospheric research in the Earth Sciences Division (610) consists of research and technology development programs dedicated to advancing knowledge and understanding of the atmosphere and its interaction with the climate of Earth. The Division's goals are to improve understanding of the dynamics and physical properties of precipitation, clouds, and aerosols; atmospheric chemistry, including the role of natural and anthropogenic trace species on the ozone balance in the stratosphere and the troposphere; and radiative properties of Earth's atmosphere and the influence of solar variability on the Earth's climate. Major research activities are carried out in the Mesoscale Atmospheric Processes Laboratory, the Climate and Radiation Laboratory, the Atmospheric Chemistry and Dynamics Laboratory, and the Wallops Field Support Office. The overall scope of the research covers an end-to-end process, starting with the identification of scientific problems, leading to observation requirements for remote-sensing platforms, technology and retrieval algorithm development; followed by flight projects and satellite missions; and eventually, resulting in data processing, analyses of measurements, and dissemination from flight projects and missions. Instrument scientists conceive, design, develop, and implement ultraviolet, infrared, optical, radar, laser, and lidar technology to remotely sense the atmosphere. Members of the various Laboratories conduct field measurements for satellite sensor calibration and data validation, and carry out numerous modeling activities. These modeling activities include climate model simulations, modeling the chemistry and transport of trace species on regional-to-global scales, cloud resolving models, and developing the next-generation Earth system models. Satellite missions, field campaigns, peer-reviewed publications, and successful proposals are essential at every stage of the research process to meeting our goals and maintaining leadership of the Earth Sciences Division in atmospheric science research. Figure 1.1 shows the 20-year record of peer-reviewed publications and proposals among the various Laboratories. This data shows that the scientific work being conducted in the Laboratories is competitive with the work being done elsewhere in universities and other government agencies. The office of Deputy Director for Atmospheric Research will strive to maintain this record by rigorously monitoring and promoting quality while emphasizing coordination and integration among atmospheric disciplines. Also, an appropriate balance will be maintained between the scientists' responsibility for large collaborative projects and missions and their need to carry out active science research as a principal investigator. This balance allows members of the Laboratories to improve their scientific credentials, and develop leadership potentials. Interdisciplinary research is carried out in collaboration with other laboratories and research groups within the Earth Sciences Division, across the Sciences and Exploration Directorate, and with partners in universities and other government agencies. Members of the Laboratories interact with the general public to support a wide range of interests in the atmospheric sciences. Among other activities, the Laboratories raise the public's awareness of atmospheric science by presenting public lectures and demonstrations, by making scientific data available to wide audiences, by teaching, and by mentoring students and teachers. The Atmosphere Laboratories make substantial efforts to attract and recruit new scientists to the various areas of atmospheric research. We strongly encourage the establishment of partnerships with Federal and state agencies that have operational responsibilities to promote the societal application of our science products. This report describes our role in NASA's mission, provides highlights of our research scope and activities, and summarizes our scientists' major accomplishments during calendar year 2014. The composition of the organization is shown in Figure 1.2 for each code. This report is published in a printed version with an electronic version on our atmospheres Web site, http://atmospheres.gsfc.nasa.gov/.

The Yeast Cyclin-Dependent Kinase Routes Carbon Fluxes to Fuel Cell Cycle Progression.

PubMed

Ewald, Jennifer C; Kuehne, Andreas; Zamboni, Nicola; Skotheim, Jan M

2016-05-19

Cell division entails a sequence of processes whose specific demands for biosynthetic precursors and energy place dynamic requirements on metabolism. However, little is known about how metabolic fluxes are coordinated with the cell division cycle. Here, we examine budding yeast to show that more than half of all measured metabolites change significantly through the cell division cycle. Cell cycle-dependent changes in central carbon metabolism are controlled by the cyclin-dependent kinase (Cdk1), a major cell cycle regulator, and the metabolic regulator protein kinase A. At the G1/S transition, Cdk1 phosphorylates and activates the enzyme Nth1, which funnels the storage carbohydrate trehalose into central carbon metabolism. Trehalose utilization fuels anabolic processes required to reliably complete cell division. Thus, the cell cycle entrains carbon metabolism to fuel biosynthesis. Because the oscillation of Cdk activity is a conserved feature of the eukaryotic cell cycle, we anticipate its frequent use in dynamically regulating metabolism for efficient proliferation. Copyright © 2016 Elsevier Inc. All rights reserved.

Division and dynamic morphology of plastids.

PubMed

Osteryoung, Katherine W; Pyke, Kevin A

2014-01-01

Plastid division is fundamental to the biology of plant cells. Division by binary fission entails the coordinated assembly and constriction of four concentric rings, two internal and two external to the organelle. The internal FtsZ ring and external dynamin-like ARC5/DRP5B ring are connected across the two envelopes by the membrane proteins ARC6, PARC6, PDV1, and PDV2. Assembly-stimulated GTPase activity drives constriction of the FtsZ and ARC5/DRP5B rings, which together with the plastid-dividing rings pull and squeeze the envelope membranes until the two daughter plastids are formed, with the final separation requiring additional proteins. The positioning of the division machinery is controlled by the chloroplast Min system, which confines FtsZ-ring formation to the plastid midpoint. The dynamic morphology of plastids, especially nongreen plastids, is also considered here, particularly in relation to the production of stromules and plastid-derived vesicles and their possible roles in cellular communication and plastid functionality.

A gender analysis of a national community health workers program: A case study of Afghanistan.

PubMed

Najafizada, Said Ahmad Maisam; Bourgeault, Ivy Lynn; Labonté, Ronald

2018-05-07

Gender equity can be a neglected issue in health system reforms. This paper explores the multiple layered gender dynamics of the Afghan Community Health Worker (CHW) Program within broader health system reforms in Afghanistan using a qualitative research design. We interviewed policy makers, health managers, CHWs and community members in 16 sites in 2013 and 2014. We found that gendered societal norms interact and influence the Afghan CHW program in a dynamic way. Gendered social norms around the division of labour tend to privilege women in terms of access to resources at the community level, but it is men who hold leadership positions that ultimately decide how the resources are to be distributed. The Afghan Ministry of Public Health expresses a commitment to gender equity, but policies on gender are restricted to reproductive health, thus constraining a gender-equity approach as focused on maternal and child health. Our explicit gender analysis not only reveals gender inequities in the Afghan CHW Program and the broader health system, it also uncovers how a highly gendered division of health labour provides some opportunities for women's empowerment that can disrupt patriarchal role constraints and broader gender inequities.

Eternal non-Markovianity: from random unitary to Markov chain realisations.

PubMed

Megier, Nina; Chruściński, Dariusz; Piilo, Jyrki; Strunz, Walter T

2017-07-25

The theoretical description of quantum dynamics in an intriguing way does not necessarily imply the underlying dynamics is indeed intriguing. Here we show how a known very interesting master equation with an always negative decay rate [eternal non-Markovianity (ENM)] arises from simple stochastic Schrödinger dynamics (random unitary dynamics). Equivalently, it may be seen as arising from a mixture of Markov (semi-group) open system dynamics. Both these approaches lead to a more general family of CPT maps, characterized by a point within a parameter triangle. Our results show how ENM quantum dynamics can be realised easily in the laboratory. Moreover, we find a quantum time-continuously measured (quantum trajectory) realisation of the dynamics of the ENM master equation based on unitary transformations and projective measurements in an extended Hilbert space, guided by a classical Markov process. Furthermore, a Gorini-Kossakowski-Sudarshan-Lindblad (GKSL) representation of the dynamics in an extended Hilbert space can be found, with a remarkable property: there is no dynamics in the ancilla state. Finally, analogous constructions for two qubits extend these results from non-CP-divisible to non-P-divisible dynamics.

Imaging of Chromosome Dynamics in Mouse Testis Tissue by Immuno-FISH.

PubMed

Scherthan, Harry

2017-01-01

The mouse (Mus musculus) represents the central mammalian genetic model system for biomedical and developmental research. Mutant mouse models have provided important insights into chromosome dynamics during the complex meiotic differentiation program that compensates for the genome doubling at fertilization. Homologous chromosomes (homologues) undergo dynamic pairing and recombine during first meiotic prophase before they become partitioned into four haploid sets by two consecutive meiotic divisions that lack an intervening S-phase. Fluorescence in situ hybridization (FISH) has been instrumental in the visualization and imaging of the dynamic reshaping of chromosome territories and mobility during prophase I, in which meiotic telomeres were found to act as pacemakers for the chromosome pairing dance. FISH combined with immunofluorescence (IF) co-staining of nuclear proteins has been instrumental for the visualization and imaging of mammalian meiotic chromosome behavior. This chapter describes FISH and IF methods for the analysis of chromosome dynamics in nuclei of paraffin-embedded mouse testes. The techniques have proven useful for fresh and archived paraffin testis material of several mammalian species.

75 FR 2878 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-19

..., Resources and Training Review Branch, Division of Extramural Activities, National Cancer Institute, 6116... Officer, Research Programs Review Branch, Division of Extramural Activities, National Cancer Institute... Ahmad, PhD, Scientific Review Officer, Research Programs Review Branch, Division of Extramural...

3rd Annual NASA Ames Space Science and Astrobiology Jamboree

NASA Technical Reports Server (NTRS)

Dotson, Jessie

2015-01-01

The Space Science and Astrobiology Division at NASA Ames Research Center consists of over 50 civil servants and more than 110 contractors, co-­-ops, post-­-docs and associates. Researchers in the division are pursuing investigations in a variety of fields including exoplanets, planetary science, astrobiology and astrophysics. In addition, division personnel support a wide variety of NASA missions including (but not limited to) Kepler, SOFIA, LADEE, JWST, and New Horizons. With such a wide variety of interesting research going on, distributed among three branches in at least 5 different buildings, it can be difficult to stay abreast of what one's fellow researchers are doing. Our goal in organizing this symposium is to facilitate communication and collaboration among the scientists within the division, and to give center management and other ARC researchers and engineers an opportunity to see what scientific research and science mission work is being done in the division. We are also continuing the tradition within the Space Science and Astrobiology Division to honor one senior and one early career scientist with the Pollack Lecture and the Early Career Lecture, respectively. With the Pollack Lecture, our intent is to select a senior researcher who has made significant contributions to any area of research within the space sciences, and we are pleased to honor Dr. William Borucki this year. With the Early Career Lecture, our intent is to select a young researcher within the division who, by their published scientific papers, shows great promise for the future in any area of space science research, and we are pleased to honor Dr. Melinda Kahre this year

Accurate Cell Division in Bacteria: How Does a Bacterium Know Where its Middle Is?

NASA Astrophysics Data System (ADS)

Howard, Martin; Rutenberg, Andrew

2004-03-01

I will discuss the physical principles lying behind the acquisition of accurate positional information in bacteria. A good application of these ideas is to the rod-shaped bacterium E. coli which divides precisely at its cellular midplane. This positioning is controlled by the Min system of proteins. These proteins coherently oscillate from end to end of the bacterium. I will present a reaction-diffusion model that describes the diffusion of the Min proteins, and their binding/unbinding from the cell membrane. The system possesses an instability that spontaneously generates the Min oscillations, which control accurate placement of the midcell division site. I will then discuss the role of fluctuations in protein dynamics, and investigate whether fluctuations set optimal protein concentration levels. Finally I will examine cell division in a different bacteria, B. subtilis. where different physical principles are used to regulate accurate cell division. See: Howard, Rutenberg, de Vet: Dynamic compartmentalization of bacteria: accurate division in E. coli. Phys. Rev. Lett. 87 278102 (2001). Howard, Rutenberg: Pattern formation inside bacteria: fluctuations due to the low copy number of proteins. Phys. Rev. Lett. 90 128102 (2003). Howard: A mechanism for polar protein localization in bacteria. J. Mol. Biol. 335 655-663 (2004).

Increasing the power of accelerated molecular dynamics methods and plans to exploit the coming exascale

NASA Astrophysics Data System (ADS)

Voter, Arthur

Many important materials processes take place on time scales that far exceed the roughly one microsecond accessible to molecular dynamics simulation. Typically, this long-time evolution is characterized by a succession of thermally activated infrequent events involving defects in the material. In the accelerated molecular dynamics (AMD) methodology, known characteristics of infrequent-event systems are exploited to make reactive events take place more frequently, in a dynamically correct way. For certain processes, this approach has been remarkably successful, offering a view of complex dynamical evolution on time scales of microseconds, milliseconds, and sometimes beyond. We have recently made advances in all three of the basic AMD methods (hyperdynamics, parallel replica dynamics, and temperature accelerated dynamics (TAD)), exploiting both algorithmic advances and novel parallelization approaches. I will describe these advances, present some examples of our latest results, and discuss what should be possible when exascale computing arrives in roughly five years. Funded by the U.S. Department of Energy, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, and by the Los Alamos Laboratory Directed Research and Development program.

Constructive Method for Detecting the Information Backflow of Non-Markovian Dynamics.

PubMed

Bylicka, Bogna; Johansson, Markus; Acín, Antonio

2017-03-24

We investigate the relation between two approaches to the characterization of quantum Markovianity, divisibility and lack of information backflow. We show that a bijective dynamical map is completely positive divisible if and only if a monotonic nonincrease of distinguishability is observed for two equiprobable states of the evolving system and an ancilla. Moreover, our proof is constructive: given any such map that is not completely positive divisible, we give an explicit construction of two states that, when taken with the same a priori probability, exhibit information backflow. Finally, while an ancilla is necessary for the equivalence to hold in general, we show that it is always possible to witness the non-Markovianity of bijective maps without using any entanglement between the system and ancilla.

Long-range ordered vorticity patterns in living tissue induced by cell division

NASA Astrophysics Data System (ADS)

Rossen, Ninna S.; Tarp, Jens M.; Mathiesen, Joachim; Jensen, Mogens H.; Oddershede, Lene B.

2014-12-01

In healthy blood vessels with a laminar blood flow, the endothelial cell division rate is low, only sufficient to replace apoptotic cells. The division rate significantly increases during embryonic development and under halted or turbulent flow. Cells in barrier tissue are connected and their motility is highly correlated. Here we investigate the long-range dynamics induced by cell division in an endothelial monolayer under non-flow conditions, mimicking the conditions during vessel formation or around blood clots. Cell divisions induce long-range, well-ordered vortex patterns extending several cell diameters away from the division site, in spite of the system’s low Reynolds number. Our experimental results are reproduced by a hydrodynamic continuum model simulating division as a local pressure increase corresponding to a local tension decrease. Such long-range physical communication may be crucial for embryonic development and for healing tissue, for instance around blood clots.

Solid State Division progress report for period ending September 30, 1984

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, P.H.; Watson, D.M.

1985-03-01

During the reporting period, relatively minor changes have occurred in the research areas of interest to the Division. Nearly all the research of the Division can be classified broadly as mission-oriented basic research. Topics covered include: theoretical solid state physics; surface and near-surface properties of solids; defects in solids; transport properties of solids; neutron scattering; and preparation and characterization of research materials. (GHT)

Environmental Sciences Division annual progress report for period ending September 30, 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-04-01

This progress report summarizes the research and development activities conducted in the Environmental Sciences Division of Oak Ridge National Laboratory during the period October 1, 1990, through September 30, 1991. The report is structured to provide descriptions of current activities and accomplishments in each of the division`s major organizational units. Following the sections describing the organizational units is a section devoted to lists of information necessary to convey the scope of the work in the division. The Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) conducts environmental research and analyses associated with both energy technology development and themore » interactions between people and the environment. The division engages in basic and applied research for a diverse list of sponsors. While the US Department of Energy (DOE) is the primary sponsor ESD staff also perform research for other federal agencies, state agencies, and private industry. The division works collaboratively with federal agencies, universities, and private organizations in achieving its research objectives and hosts a large number of visiting investigators from these organizations. Given the diverse interdisciplinary specialization of its staff, ESD provides technical expertise on complex environmental problems and renders technical leadership for major environmental issues of national and local concern. This progress report highlights many of ESD`s accomplishment in these and other areas in FY 1991.« less

Summaries of research projects for fiscal years 1996 and 1997, medical applications and biophysical research

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The Medical Applications and Biophysical Research Division of the Office of Biological and Environmental Research supports and manages research in several distinct areas of science and technology. The projects described in this book are grouped by the main budgetary areas: General Life Sciences (structural molecular biology), Medical Applications (primarily nuclear medicine) and Measurement Science (analytical chemistry instrumentation), Environmental Management Science Program, and the Small Business Innovation Research Program. The research funded by this division complements that of the other two divisions in the Office of Biological and Environmental Research (OBER): Health Effects and Life Sciences Research, and Environmental Sciences. Mostmore » of the OBER programs are planned and administered jointly by the staff of two or all three of the divisions. This summary book provides information on research supported in these program areas during Fiscal Years 1996 and 1997.« less

Second Annual NASA Ames Space Science and Astrobiology Jamboree

NASA Technical Reports Server (NTRS)

Dotson, Jessie

2014-01-01

The Space Science and Astrobiology Division's researchers are pursuing investigations in a variety of fields, including exoplanets, planetary science, astrobiology, and astrophysics. In addition division personnel support a wide variety of NASA missions. With a wide variety of interesting research going on, distributed among the three branches in at least 5 buildings, it can be difficult to stay abreast of what one's fellow researchers are doing. Our goal in organizing this symposium is to facilitate communication and collaboration among the scientist within the division and to give center management and other ARC researchers and Engineers an opportunity to see what scientific missions work is being done in the division.

EGenBio: A Data Management System for Evolutionary Genomics and Biodiversity

PubMed Central

Nahum, Laila A; Reynolds, Matthew T; Wang, Zhengyuan O; Faith, Jeremiah J; Jonna, Rahul; Jiang, Zhi J; Meyer, Thomas J; Pollock, David D

2006-01-01

Background Evolutionary genomics requires management and filtering of large numbers of diverse genomic sequences for accurate analysis and inference on evolutionary processes of genomic and functional change. We developed Evolutionary Genomics and Biodiversity (EGenBio; ) to begin to address this. Description EGenBio is a system for manipulation and filtering of large numbers of sequences, integrating curated sequence alignments and phylogenetic trees, managing evolutionary analyses, and visualizing their output. EGenBio is organized into three conceptual divisions, Evolution, Genomics, and Biodiversity. The Genomics division includes tools for selecting pre-aligned sequences from different genes and species, and for modifying and filtering these alignments for further analysis. Species searches are handled through queries that can be modified based on a tree-based navigation system and saved. The Biodiversity division contains tools for analyzing individual sequences or sequence alignments, whereas the Evolution division contains tools involving phylogenetic trees. Alignments are annotated with analytical results and modification history using our PRAED format. A miscellaneous Tools section and Help framework are also available. EGenBio was developed around our comparative genomic research and a prototype database of mtDNA genomes. It utilizes MySQL-relational databases and dynamic page generation, and calls numerous custom programs. Conclusion EGenBio was designed to serve as a platform for tools and resources to ease combined analysis in evolution, genomics, and biodiversity. PMID:17118150

78 FR 28630 - Pfizer Therapeutic Research, Pfizer Worldwide Research & Development Division, Formerly Known as...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-15

..., Comparative Medicine Department, Including On-Site Leased From Charles River Laboratories and Execupharm, Inc... & Development Division, Comparative Medicine Department, including on-site leased workers from Charles River... Division, formerly known as Warner Lambert Company, Comparative Medicine Department. The Department has...

DIVISION OF ISOTOPES DEVELOPMENT RESEARCH AND DEVELOPMENT PROJECTS: 1968. Progress Reports on Sponsored Work.

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1969-01-01

This is the second edition of the Division of Isotopes Development project summaries. It presents a short summary of objectives, results, and future plans for each research or development project sponsored by the Division within each of eight program areas.

Cognitive and Neural Sciences Division, 1991 Programs.

ERIC Educational Resources Information Center

Vaughan, Willard S., Ed.

This report documents research and development performed under the sponsorship of the Cognitive and Neural Sciences Division of the Office of Naval Research in fiscal year 1991. It provides abstracts (title, principal investigator, project code, objective, approach, progress, and related reports) of projects of three program divisions (cognitive…

Atmospheric Research 2012 Technical Highlights

NASA Technical Reports Server (NTRS)

Lau, William K -M.

2013-01-01

This annual report, as before, is intended for a broad audience. Our readers include colleagues within NASA, scientists outside the Agency, science graduate students, and members of the general public. Inside are descriptions of atmospheric research science highlights and summaries of our education and outreach accomplishments for calendar year 2012.The report covers research activities from the Mesoscale Atmospheric Processes Laboratory, the Climate and Radiation Laboratory, the Atmospheric Chemistry and Dynamics Laboratory, and the Wallops Field Support Office under the Office of Deputy Director for Atmospheres, Earth Sciences Division in the Sciences and Exploration Directorate of NASAs Goddard Space Flight Center. The overall mission of the office is advancing knowledge and understanding of the Earths atmosphere. Satellite missions, field campaigns, peer-reviewed publications, and successful proposals are essential to our continuing research.

NASA Lewis Research Center Workshop on Forced Response in Turbomachinery

NASA Technical Reports Server (NTRS)

Stefko, George L. (Compiler); Murthy, Durbha V. (Compiler); Morel, Michael (Compiler); Hoyniak, Dan (Compiler); Gauntner, Jim W. (Compiler)

1994-01-01

A summary of the NASA Lewis Research Center (LeRC) Workshop on Forced Response in Turbomachinery in August, 1993 is presented. It was sponsored by the following NASA organizations: Structures, Space Propulsion Technology, and Propulsion Systems Divisions of NASA LeRC and the Aeronautics and Advanced Concepts & Technology Offices of NASA Headquarters. In addition, the workshop was held in conjunction with the GUIde (Government/Industry/Universities) Consortium on Forced Response. The workshop was specifically designed to receive suggestions and comments from industry on current research at NASA LeRC in the area of forced vibratory response of turbomachinery blades which includes both computational and experimental approaches. There were eight presentations and a code demonstration. Major areas of research included aeroelastic response, steady and unsteady fluid dynamics, mistuning, and corresponding experimental work.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mann, Reinhold C.

This is the first formal progress report issued by the ORNL Life Sciences Division. It covers the period from February 1997 through December 1998, which has been critical in the formation of our new division. The legacy of 50 years of excellence in biological research at ORNL has been an important driver for everyone in the division to do their part so that this new research division can realize the potential it has to make seminal contributions to the life sciences for years to come. This reporting period is characterized by intense assessment and planning efforts. They included thorough scrutinymore » of our strengths and weaknesses, analyses of our situation with respect to comparative research organizations, and identification of major thrust areas leading to core research efforts that take advantage of our special facilities and expertise. Our goal is to develop significant research and development (R&D) programs in selected important areas to which we can make significant contributions by combining our distinctive expertise and resources in the biological sciences with those in the physical, engineering, and computational sciences. Significant facilities in mouse genomics, mass spectrometry, neutron science, bioanalytical technologies, and high performance computing are critical to the success of our programs. Research and development efforts in the division are organized in six sections. These cluster into two broad areas of R&D: systems biology and technology applications. The systems biology part of the division encompasses our core biological research programs. It includes the Mammalian Genetics and Development Section, the Biochemistry and Biophysics Section, and the Computational Biosciences Section. The technology applications part of the division encompasses the Assessment Technology Section, the Environmental Technology Section, and the Toxicology and Risk Analysis Section. These sections are the stewards of the division's core competencies. The common mission of the division is to advance science and technology to understand complex biological systems and their relationship with human health and the environment.« less

AN OVERVIEW OF PATHOGEN RESEARCH IN THE MICROBIOLOGICAL AND CHEMICAL EXPOSURE ASSESSMENT RESEARCH DIVISION

EPA Science Inventory

The Microbiological and Chemical Exposure Assessment Research Division of the EPA Office of Research and Development's National Exposure Research Laboratory has a robust in-house research program aimed at developing better occurrence and exposure methods for waterborne pathogens....

Dynamic Divisive Normalization Predicts Time-Varying Value Coding in Decision-Related Circuits

PubMed Central

LoFaro, Thomas; Webb, Ryan; Glimcher, Paul W.

2014-01-01

Normalization is a widespread neural computation, mediating divisive gain control in sensory processing and implementing a context-dependent value code in decision-related frontal and parietal cortices. Although decision-making is a dynamic process with complex temporal characteristics, most models of normalization are time-independent and little is known about the dynamic interaction of normalization and choice. Here, we show that a simple differential equation model of normalization explains the characteristic phasic-sustained pattern of cortical decision activity and predicts specific normalization dynamics: value coding during initial transients, time-varying value modulation, and delayed onset of contextual information. Empirically, we observe these predicted dynamics in saccade-related neurons in monkey lateral intraparietal cortex. Furthermore, such models naturally incorporate a time-weighted average of past activity, implementing an intrinsic reference-dependence in value coding. These results suggest that a single network mechanism can explain both transient and sustained decision activity, emphasizing the importance of a dynamic view of normalization in neural coding. PMID:25429145

Aerodynamic Investigation of C-141 Leading Edge Modifications for Cruise Drag Reduction--Test 2.

DTIC Science & Technology

1981-04-01

82171.6 1 ((1 I III 11 1 - MI( RO( )FY R~ I IN II I (I 041PI AD A099 6 6 2 _ AFWAL-TR-81-3032 AERODYNAMIC INVESTIGATION OF C-141 LEADING EDGE MODIFICATIONS...FOR CRUISE DRAG REDUCTION -- TEST 2 Robert A. Large, Captain, USAF Aerodynamics & Airframe Branch Aeromechanics Division Flight Dynamics Laboratory...KEMloUA Ch, Aerodynamics & Airframe Br Aeromechanics Division FOR THE COMMANDER hie" Aeromechanics Division "If your address has changed, if you wish to

Dynamic segment shared protection for multicast traffic in meshed wavelength-division-multiplexing optical networks

NASA Astrophysics Data System (ADS)

Liao, Luhua; Li, Lemin; Wang, Sheng

2006-12-01

We investigate the protection approach for dynamic multicast traffic under shared risk link group (SRLG) constraints in meshed wavelength-division-multiplexing optical networks. We present a shared protection algorithm called dynamic segment shared protection for multicast traffic (DSSPM), which can dynamically adjust the link cost according to the current network state and can establish a primary light-tree as well as corresponding SRLG-disjoint backup segments for a dependable multicast connection. A backup segment can efficiently share the wavelength capacity of its working tree and the common resources of other backup segments based on SRLG-disjoint constraints. The simulation results show that DSSPM not only can protect the multicast sessions against a single-SRLG breakdown, but can make better use of the wavelength resources and also lower the network blocking probability.

Quantitation of Cellular Dynamics in Growing Arabidopsis Roots with Light Sheet Microscopy

PubMed Central

Birnbaum, Kenneth D.; Leibler, Stanislas

2011-01-01

To understand dynamic developmental processes, living tissues have to be imaged frequently and for extended periods of time. Root development is extensively studied at cellular resolution to understand basic mechanisms underlying pattern formation and maintenance in plants. Unfortunately, ensuring continuous specimen access, while preserving physiological conditions and preventing photo-damage, poses major barriers to measurements of cellular dynamics in growing organs such as plant roots. We present a system that integrates optical sectioning through light sheet fluorescence microscopy with hydroponic culture that enables us to image, at cellular resolution, a vertically growing Arabidopsis root every few minutes and for several consecutive days. We describe novel automated routines to track the root tip as it grows, to track cellular nuclei and to identify cell divisions. We demonstrate the system's capabilities by collecting data on divisions and nuclear dynamics. PMID:21731697

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The primary purpose of this report is to provide an archival record of the activities of the Engineering Physics and Mathematics Division during the period September 1, 1989 through March 31, 1991. Earlier reports in this series are identified on the previous pages, along with the progress reports describing ORNL's research on the mathematical sciences prior to 1984 when those activities moved into the division. As in previous reports, our research is described through abstracts of journal articles, technical reports, and presentations. Summary lists of publications and presentations, staff additions and departures, scientific and professional activities of division staff, andmore » technical conferences organized and sponsored by the division are included as appendices. The report is organized following the division of our research among four sections and information centers. These research areas are: Mathematical Sciences; Nuclear Data Measurement and Evaluations; Intelligent Systems; Nuclear Analysis and Shielding; and Engineering Physics Information Center.« less

Multiple-division of self-propelled oil droplets through acetal formation.

PubMed

Banno, Taisuke; Kuroha, Rie; Miura, Shingo; Toyota, Taro

2015-02-28

We demonstrate a novel system that exhibits both self-propelled motion and division of micrometer-sized oil droplets induced by chemical conversion of the system components. Such unique dynamics were observed in an oil-in-water emulsion of a benzaldehyde derivative, an alkanol and a cationic surfactant at a low pH.

Energy efficient flexible hybrid wavelength division multiplexing-time division multiplexing passive optical network with pay as you grow deployment

NASA Astrophysics Data System (ADS)

Garg, Amit Kumar; Madavi, Amresh Ashok; Janyani, Vijay

2017-02-01

A flexible hybrid wavelength division multiplexing-time division multiplexing passive optical network architecture that allows dual rate signals to be sent at 1 and 10 Gbps to each optical networking unit depending upon the traffic load is proposed. The proposed design allows dynamic wavelength allocation with pay-as-you-grow deployment capability. This architecture is capable of providing up to 40 Gbps of equal data rates to all optical distribution networks (ODNs) and up to 70 Gbps of a asymmetrical data rate to the specific ODN. The proposed design handles broadcasting capability with simultaneous point-to-point transmission, which further reduces energy consumption. In this architecture, each module sends a wavelength to each ODN, thus making the architecture fully flexible; this flexibility allows network providers to use only required OLT components and switch off others. The design is also reliable to any module or TRx failure and provides services without any service disruption. Dynamic wavelength allocation and pay-as-you-grow deployment support network extensibility and bandwidth scalability to handle future generation access networks.

ZapE Is a Novel Cell Division Protein Interacting with FtsZ and Modulating the Z-Ring Dynamics

PubMed Central

Marteyn, Benoit S.; Karimova, Gouzel; Fenton, Andrew K.; Gazi, Anastasia D.; West, Nicholas; Touqui, Lhousseine; Prevost, Marie-Christine; Betton, Jean-Michel; Poyraz, Oemer; Ladant, Daniel; Gerdes, Kenn; Sansonetti, Philippe J.; Tang, Christoph M.

2014-01-01

ABSTRACT Bacterial cell division requires the formation of a mature divisome complex positioned at the midcell. The localization of the divisome complex is determined by the correct positioning, assembly, and constriction of the FtsZ ring (Z-ring). Z-ring constriction control remains poorly understood and (to some extent) controversial, probably due to the fact that this phenomenon is transient and controlled by numerous factors. Here, we characterize ZapE, a novel ATPase found in Gram-negative bacteria, which is required for growth under conditions of low oxygen, while loss of zapE results in temperature-dependent elongation of cell shape. We found that ZapE is recruited to the Z-ring during late stages of the cell division process and correlates with constriction of the Z-ring. Overexpression or inactivation of zapE leads to elongation of Escherichia coli and affects the dynamics of the Z-ring during division. In vitro, ZapE destabilizes FtsZ polymers in an ATP-dependent manner. PMID:24595368

GENETIC INDICATORS IN ENVIRONMENTAL PROTECTION

EPA Science Inventory

University of California, Davis, Bodega Bay Marine Laboratory; US EPA National Exposure Research Laboratory, Molecular Ecology Research Division, Cincinnati, OH; US EPA National Health and Environmental Effects Research Laboratory (NHEERL), Gulf Ecology Division, Gulf Breeze, FL;...

NACA0012 benchmark model experimental flutter results with unsteady pressure distributions

NASA Technical Reports Server (NTRS)

Rivera, Jose A., Jr.; Dansberry, Bryan E.; Bennett, Robert M.; Durham, Michael H.; Silva, Walter A.

1992-01-01

The Structural Dynamics Division at NASA Langley Research Center has started a wind tunnel activity referred to as the Benchmark Models Program. The primary objective of this program is to acquire measured dynamic instability and corresponding pressure data that will be useful for developing and evaluating aeroelastic type computational fluid dynamics codes currently in use or under development. The program is a multi-year activity that will involve testing of several different models to investigate various aeroelastic phenomena. This paper describes results obtained from a second wind tunnel test of the first model in the Benchmark Models Program. This first model consisted of a rigid semispan wing having a rectangular planform and a NACA 0012 airfoil shape which was mounted on a flexible two degree of freedom mount system. Experimental flutter boundaries and corresponding unsteady pressure distribution data acquired over two model chords located at the 60 and 95 percent span stations are presented.

Advanced optical fiber communication systems

NASA Astrophysics Data System (ADS)

Kazovsky, Leonid G.

1994-03-01

Our research is focused on three major aspects of advanced optical fiber communication systems: dynamic wavelength division multiplexing (WDM) networks, fiber nonlinearities, and high dynamic range coherent analog optical links. In the area of WDM networks, we have designed and implemented two high-speed interface boards and measured their throughput and latency. Furthermore, we designed and constructed an experimental PSK/ASK transceiver that simultaneously transmits packet-switched ASK data and circuit-switched PSK data on the same optical carrier. In the area of fiber nonlinearities, we investigated the theoretical impact of modulation frequency on cross-phase modulation (XPM) in dispersive fibers. In the area of high dynamic range coherent analog optical links, we developed theoretical expressions for the RF power transfer ratio (or RF power gain) and the noise figure (NF) of angle-modulated links. We then compared the RF power gains and noise figures of these links to that of an intensity modulated direct detection (DD) link.

Towards understanding software: 15 years in the SEL

NASA Technical Reports Server (NTRS)

Mcgarry, Frank; Pajerski, Rose

1990-01-01

For 15 years, the Software Engineering Laboratory (SEL) at GSFC has been carrying out studies and experiments for the purpose of understanding, assessing, and improving software, and software processes within a production software environment. The SEL comprises three major organizations: (1) the GSFC Flight Dynamics Division; (2) the University of Maryland Computer Science Department; and (3) the Computer Sciences Corporation Flight Dynamics Technology Group. These organizations have jointly carried out several hundred software studies, producing hundreds of reports, papers, and documents: all describing some aspect of the software engineering technology that has undergone analysis in the flight dynamics environment. The studies range from small controlled experiments (such as analyzing the effectiveness of code reading versus functional testing) to large, multiple-project studies (such as assessing the impacts of Ada on a production environment). The key findings that NASA feels have laid the foundation for ongoing and future software development and research activities are summarized.

Solar Dynamics Observatory Briefing

NASA Image and Video Library

2010-01-21

Richard Fisher, Heliophysics Division Director at NASA Headquarters, speaks during a briefing to discuss the upcoming launch of NASA's Solar Dynamic Observatory, or SDO, Thursday, Jan. 21, 2010, at NASA Headquarters in Washington. The mission is to study the Sun and its dynamic behavior. Photo Credit: (NASA/Paul E. Alers)

Aerospace Human Factors

NASA Technical Reports Server (NTRS)

Jordan, Kevin

1999-01-01

The following contains the final report on the activities related to the Cooperative Agreement between the human factors research group at NASA Ames Research Center and the Psychology Department at San Jose State University. The participating NASA Ames division has been, as the organization has changed, the Aerospace Human Factors Research Division (ASHFRD and Code FL), the Flight Management and Human Factors Research Division (Code AF), and the Human Factors Research and Technology Division (Code IH). The inclusive dates for the report are November 1, 1984 to January 31, 1999. Throughout the years, approximately 170 persons worked on the cooperative agreements in one capacity or another. The Cooperative Agreement provided for research personnel to collaborate with senior scientists in ongoing NASA ARC research. Finally, many post-MA/MS and post-doctoral personnel contributed to the projects. It is worth noting that 10 former cooperative agreement personnel were hired into civil service positions directly from the agreements.

Natural hazards Early career scientist Team (NhET), a newborn group bridging science to a broader community

NASA Astrophysics Data System (ADS)

Lombardo, Luigi; Cigala, Valeria; Rizzi, Jonathan; Craciun, Iulya; Gain, Animesh Kumar; Albano, Raffaele

2017-04-01

Alongside with other major EGU divisions, Natural Hazard has recently formed his Early Career Scientist (ECS) team, known as NhET. NhET was born in 2016 and its scope includes various activities for the EGU members, the international scientific community as well as for the general public. We are a group of six early career researchers, either PhDs or Post-Docs, from different fields of Natural Hazard, keen to promote knowledge exchanges and collaborations. This is done by organizing courses, training sessions and social activities, especially targeting ECSs, during the EGU General Assembly for this year and the next to come. Outside the timeframe of the EGU conference, we constantly promote EGU contents for our division. This is done through the division website (http://www.egu.eu/nh), a mailing list (https://groups.google.com/forum/#!forum/nhet) and social media. With respect to the latter, a new Facebook page will be launched shortly and other platforms such as Twitter will be used to reach a broader audience. These platforms will foster the transmission of Natural Hazard topics to anyone who is interested. The main content will be researchers' interviews, information about open positions, trainings, open source software, conferences together with news on hazards and their anthropic and environmental impacts. We are NhET and we invite you all to follow and collaborate with us for a more dynamic, efficient and widespread scientific communication.

Environmental Sciences Division annual progress report for period ending September 30, 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-04-01

This progress report summarizes the research and development activities conducted in the Environmental Sciences Division of Oak Ridge National Laboratory during the period October 1, 1990, through September 30, 1991. The report is structured to provide descriptions of current activities and accomplishments in each of the division's major organizational units. Following the sections describing the organizational units is a section devoted to lists of information necessary to convey the scope of the work in the division. The Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) conducts environmental research and analyses associated with both energy technology development and themore » interactions between people and the environment. The division engages in basic and applied research for a diverse list of sponsors. While the US Department of Energy (DOE) is the primary sponsor ESD staff also perform research for other federal agencies, state agencies, and private industry. The division works collaboratively with federal agencies, universities, and private organizations in achieving its research objectives and hosts a large number of visiting investigators from these organizations. Given the diverse interdisciplinary specialization of its staff, ESD provides technical expertise on complex environmental problems and renders technical leadership for major environmental issues of national and local concern. This progress report highlights many of ESD's accomplishment in these and other areas in FY 1991.« less

Molecular coordination of Staphylococcus aureus cell division

PubMed Central

Cotterell, Bryony E; Walther, Christa G; Fenn, Samuel J; Grein, Fabian; Wollman, Adam JM; Leake, Mark C; Olivier, Nicolas; Cadby, Ashley; Mesnage, Stéphane; Jones, Simon

2018-01-01

The bacterial cell wall is essential for viability, but despite its ability to withstand internal turgor must remain dynamic to permit growth and division. Peptidoglycan is the major cell wall structural polymer, whose synthesis requires multiple interacting components. The human pathogen Staphylococcus aureus is a prolate spheroid that divides in three orthogonal planes. Here, we have integrated cellular morphology during division with molecular level resolution imaging of peptidoglycan synthesis and the components responsible. Synthesis occurs across the developing septal surface in a diffuse pattern, a necessity of the observed septal geometry, that is matched by variegated division component distribution. Synthesis continues after septal annulus completion, where the core division component FtsZ remains. The novel molecular level information requires re-evaluation of the growth and division processes leading to a new conceptual model, whereby the cell cycle is expedited by a set of functionally connected but not regularly distributed components. PMID:29465397

Peptidoglycan architecture can specify division planes in Staphylococcus aureus.

PubMed

Turner, Robert D; Ratcliffe, Emma C; Wheeler, Richard; Golestanian, Ramin; Hobbs, Jamie K; Foster, Simon J

2010-06-15

Division in Staphylococci occurs equatorially and on specific sequentially orthogonal planes in three dimensions, resulting, after incomplete cell separation, in the 'bunch of grapes' cluster organization that defines the genus. The shape of Staphylococci is principally maintained by peptidoglycan. In this study, we use Atomic Force Microscopy (AFM) and fluorescence microscopy with vancomycin labelling to examine purified peptidoglycan architecture and its dynamics in Staphylococcus aureus and correlate these with the cell cycle. At the presumptive septum, cells were found to form a large belt of peptidoglycan in the division plane before the centripetal formation of the septal disc; this often had a 'piecrust' texture. After division, the structures remain as orthogonal ribs, encoding the location of past division planes in the cell wall. We propose that this epigenetic information is used to enable S. aureus to divide in sequentially orthogonal planes, explaining how a spherical organism can maintain division plane localization with fidelity over many generations.

Assessing Student Reasoning in Upper-Division Electricity and Magnetism at Oregon State University

ERIC Educational Resources Information Center

Zwolak, Justyna P.; Manogue, Corinne A.

2015-01-01

Standardized assessment tests that allow researchers to compare the performance of students under various curricula are highly desirable. There are several research-based conceptual tests that serve as instruments to assess and identify students' difficulties in lower-division courses. At the upper-division level assessing students' difficulties…

Friday's Agenda | Division of Cancer Prevention

Cancer.gov

TimeAgenda8:00 am - 8:10 amWelcome and Opening RemarksLeslie Ford, MDAssociate Director for Clinical ResearchDivision of Cancer Prevention, NCIEva Szabo, MD Chief, Lung and Upper Aerodigestive Cancer Research GroupDivision of Cancer Prevention, NCI8:10 am - 8:40 amClinical Trials Statistical Concepts for Non-StatisticiansKevin Dodd, PhD |

Mechanical Forces Program the Orientation of Cell Division during Airway Tube Morphogenesis.

PubMed

Tang, Zan; Hu, Yucheng; Wang, Zheng; Jiang, Kewu; Zhan, Cheng; Marshall, Wallace F; Tang, Nan

2018-02-05

Oriented cell division plays a key role in controlling organogenesis. The mechanisms for regulating division orientation at the whole-organ level are only starting to become understood. By combining 3D time-lapse imaging, mouse genetics, and mathematical modeling, we find that global orientation of cell division is the result of a combination of two types of spindles with distinct spindle dynamic behaviors in the developing airway epithelium. Fixed spindles follow the classic long-axis rule and establish their division orientation before metaphase. In contrast, rotating spindles do not strictly follow the long-axis rule and determine their division orientation during metaphase. By using both a cell-based mechanical model and stretching-lung-explant experiments, we showed that mechanical force can function as a regulatory signal in maintaining the stable ratio between fixed spindles and rotating spindles. Our findings demonstrate that mechanical forces, cell geometry, and oriented cell division function together in a highly coordinated manner to ensure normal airway tube morphogenesis. Copyright © 2017 Elsevier Inc. All rights reserved.

Non-Markovianity Measure Based on Brukner-Zeilinger Invariant Information for Unital Quantum Dynamical Maps

NASA Astrophysics Data System (ADS)

He, Zhi; Zhu, Lie-Qiang; Li, Li

2017-03-01

A non-Markovianity measure based on Brukner-Zeilinger invariant information to characterize non-Markovian effect of open systems undergoing unital dynamical maps is proposed. The method takes advantage of non-increasing property of the Brukner-Zeilinger invariant information under completely positive and trace-preserving unital maps. The simplicity of computing the Brukner-Zeilinger invariant information is the advantage of the proposed measure because of mainly depending on the purity of quantum state. The measure effectively captures the characteristics of non-Markovianity of unital dynamical maps. As some concrete application, we consider two typical non-Markovian noise channels, i.e., the phase damping channel and the random unitary channel to show the sensitivity of the proposed measure. By investigation, we find that the conditions of detecting the non-Markovianity for the phase damping channel are consistent with the results of existing measures for non-Markovianity, i.e., information flow, divisibility and quantum mutual information. However, for the random unitary channel non-Markovian conditions are same to that of the information flow, but is different from that of the divisibility and quantum mutual information. Supported by the National Natural Science Foundation of China under Grant No. 61505053, the Natural Science Foundation of Hunan Province under Grant No. 2015JJ3092, the Research Foundation of Education Bureau of Hunan Province, China under Grant No. 16B177, the School Foundation from the Hunan University of Arts and Science under Grant No. 14ZD01

PhOTO Zebrafish: A Transgenic Resource for In Vivo Lineage Tracing during Development and Regeneration

PubMed Central

Dempsey, William P.; Fraser, Scott E.; Pantazis, Periklis

2012-01-01

Background Elucidating the complex cell dynamics (divisions, movement, morphological changes, etc.) underlying embryonic development and adult tissue regeneration requires an efficient means to track cells with high fidelity in space and time. To satisfy this criterion, we developed a transgenic zebrafish line, called PhOTO, that allows photoconvertible optical tracking of nuclear and membrane dynamics in vivo. Methodology PhOTO zebrafish ubiquitously express targeted blue fluorescent protein (FP) Cerulean and photoconvertible FP Dendra2 fusions, allowing for instantaneous, precise targeting and tracking of any number of cells using Dendra2 photoconversion while simultaneously monitoring global cell behavior and morphology. Expression persists through adulthood, making the PhOTO zebrafish an excellent tool for studying tissue regeneration: after tail fin amputation and photoconversion of a ∼100µm stripe along the cut area, marked differences seen in how cells contribute to the new tissue give detailed insight into the dynamic process of regeneration. Photoconverted cells that contributed to the regenerate were separated into three distinct populations corresponding to the extent of cell division 7 days after amputation, and a subset of cells that divided the least were organized into an evenly spaced, linear orientation along the length of the newly regenerating fin. Conclusions/Significance PhOTO zebrafish have wide applicability for lineage tracing at the systems-level in the early embryo as well as in the adult, making them ideal candidate tools for future research in development, traumatic injury and regeneration, cancer progression, and stem cell behavior. PMID:22431986

DCP's Early Detection Research Guides Future Science | Division of Cancer Prevention

Cancer.gov

Early detection research funded by the NCI's Division of Cancer Prevention has positively steered both public health and clinical outcomes, and set the stage for findings in the next generation of research. |

Multisensory integration: flexible use of general operations

PubMed Central

van Atteveldt, Nienke; Murray, Micah M.; Thut, Gregor; Schroeder, Charles

2014-01-01

Research into the anatomical substrates and “principles” for integrating inputs from separate sensory surfaces has yielded divergent findings. This suggests that multisensory integration is flexible and context-dependent, and underlines the need for dynamically adaptive neuronal integration mechanisms. We propose that flexible multisensory integration can be explained by a combination of canonical, population-level integrative operations, such as oscillatory phase-resetting and divisive normalization. These canonical operations subsume multisensory integration into a fundamental set of principles as to how the brain integrates all sorts of information, and they are being used proactively and adaptively. We illustrate this proposition by unifying recent findings from different research themes such as timing, behavioral goal and experience-related differences in integration. PMID:24656248

The Science of Cancer Prevention

Cancer.gov

The science of cancer prevention is described by Dr. Barnett S. Kramer, M.D., M.P.H., director of the Division of Cancer Prevention, National Cancer Institute (NCI). The Division of Cancer Prevention administers a broad spectrum of research that spans basic pre-clinical, laboratory research, supportive and palliative care research, early detection, and randomized controlled clinical trials. The Division also supports the Cancer Prevention Fellowship Program and is devoted to the balanced communication of scientific results.

Space Science Division cumulative bibliography: 1989-1994

NASA Technical Reports Server (NTRS)

Morrison, D.

1995-01-01

The Space Science Division at NASA's Ames Research Center is dedicated to research in astrophysics, exobiology, and planetary science. These research programs are structured around the study of origins and evolution of stars, planets, planetary atmospheres, and life, and address some of the most fundamental questions pursued by science; questions that examine the origin of life and of our place in the universe. This bibliography is the accumulation of peer-reviewed publications authored by Division scientists for the years 1989 through 1994. The list includes 777 papers published in over 5 dozen scientific journals representing the high productivity and interdisciplinary nature of the Space Science Division.

Physics division annual report 2006.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glover, J.; Physics

2008-02-28

This report highlights the activities of the Physics Division of Argonne National Laboratory in 2006. The Division's programs include the operation as a national user facility of ATLAS, the Argonne Tandem Linear Accelerator System, research in nuclear structure and reactions, nuclear astrophysics, nuclear theory, investigations in medium-energy nuclear physics as well as research and development in accelerator technology. The mission of nuclear physics is to understand the origin, evolution and structure of baryonic matter in the universe--the core of matter, the fuel of stars, and the basic constituent of life itself. The Division's research focuses on innovative new ways tomore » address this mission.« less

Mitotic Cortical Waves Predict Future Division Sites by Encoding Positional and Size Information.

PubMed

Xiao, Shengping; Tong, Cheesan; Yang, Yang; Wu, Min

2017-11-20

Dynamic spatial patterns such as traveling waves could theoretically encode spatial information, but little is known about whether or how they are employed by biological systems, especially higher eukaryotes. Here, we show that concentric target or spiral waves of active Cdc42 and the F-BAR protein FBP17 are invoked in adherent cells at the onset of mitosis. These waves predict the future sites of cell divisions and represent the earliest known spatial cues for furrow assembly. Unlike interphase waves, the frequencies and wavelengths of the mitotic waves display size-dependent scaling properties. While the positioning role of the metaphase waves requires microtubule dynamics, spindle and microtubule-independent inhibitory signals are propagated by the mitotic waves to ensure the singularity of furrow formation. Taken together, we propose that metaphase cortical waves integrate positional and cell size information for division-plane specification in adhesion-dependent cytokinesis. Copyright © 2017 Elsevier Inc. All rights reserved.

A New Model for the Estimation of Cell Proliferation Dynamics Using CFSE Data

PubMed Central

Banks, H.T.; Sutton, Karyn L.; Thompson, W. Clayton; Bocharov, Gennady; Doumic, Marie; Schenkel, Tim; Argilaguet, Jordi; Giest, Sandra; Peligero, Cristina; Meyerhans, Andreas

2011-01-01

CFSE analysis of a proliferating cell population is a popular tool for the study of cell division and division-linked changes in cell behavior. Recently [13, 43, 45], a partial differential equation (PDE) model to describe lymphocyte dynamics in a CFSE proliferation assay was proposed. We present a significant revision of this model which improves the physiological understanding of several parameters. Namely, the parameter γ used previously as a heuristic explanation for the dilution of CFSE dye by cell division is replaced with a more physical component, cellular autofluorescence. The rate at which label decays is also quantified using a Gompertz decay process. We then demonstrate a revised method of fitting the model to the commonly used histogram representation of the data. It is shown that these improvements result in a model with a strong physiological basis which is fully capable of replicating the behavior observed in the data. PMID:21889510

Biomedical Research Division significant accomplishments for FY 1983

NASA Technical Reports Server (NTRS)

Martello, N. V.

1984-01-01

Various research and technology activities of Ames Research Center's Biomedical Research Division are described. Contributions to the Space Administration's goals in the life sciences include research in operational medicine, cardiovascular deconditioning, motion sickness, bone alterations, muscle atrophy, fluid and electrolyte changes, radiation effects and protection, human behavior and performance, general biomedical research, and gravitational biology.

Functional Organization and Dynamic Activity in the Superior Colliculus of the Echolocating Bat, Eptesicus fuscus.

PubMed

Wohlgemuth, Melville J; Kothari, Ninad B; Moss, Cynthia F

2018-01-03

Sensory-guided behaviors require the transformation of sensory information into task-specific motor commands. Prior research on sensorimotor integration has emphasized visuomotor processes in the context of simplified orienting movements in controlled laboratory tasks rather than an animal's more complete, natural behavioral repertoire. Here, we conducted a series of neural recording experiments in the midbrain superior colliculus (SC) of echolocating bats engaged in a sonar target-tracking task that invoked dynamic active sensing behaviors. We hypothesized that SC activity in freely behaving animals would reveal dynamic shifts in neural firing patterns within and across sensory, sensorimotor, and premotor layers. We recorded neural activity in the SC of freely echolocating bats (three females and one male) and replicated the general trends reported in other species with sensory responses in the dorsal divisions and premotor activity in ventral divisions of the SC. However, within this coarse functional organization, we discovered that sensory and motor neurons are comingled within layers throughout the volume of the bat SC. In addition, as the bat increased pulse rate adaptively to increase resolution of the target location with closing distance, the activity of sensory and vocal premotor neurons changed such that auditory response times decreased, and vocal premotor lead times shortened. This finding demonstrates that SC activity can be modified dynamically in concert with adaptive behaviors and suggests that an integrated functional organization within SC laminae supports rapid and local integration of sensory and motor signals for natural, adaptive behaviors. SIGNIFICANCE STATEMENT Natural sensory-guided behaviors involve the rapid integration of information from the environment to direct flexible motor actions. The vast majority of research on sensorimotor integration has used artificial stimuli and simplified behaviors, leaving open questions about nervous system function in the context of natural tasks. Our work investigated mechanisms of dynamic sensorimotor feedback control by analyzing patterns of neural activity in the midbrain superior colliculus (SC) of an echolocating bat tracking and intercepting moving prey. Recordings revealed that sensory and motor neurons comingle within laminae of the SC to support rapid sensorimotor integration. Further, we discovered that neural activity in the bat SC changes with dynamic adaptations in the animal's echolocation behavior. Copyright © 2018 the authors 0270-6474/18/380245-12$15.00/0.

Biology Division progress report, October 1, 1991--September 30, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hartman, F.C.; Cook, J.S.

This Progress Report summarizes the research endeavors of the Biology Division of the Oak Ridge National Laboratory during the period October 1, 1991, through September 30, 1993. The report is structured to provide descriptions of current activities and accomplishments in each of the Division`s major organizational units. Lists of information to convey the entire scope of the Division`s activities are compiled at the end of the report.

RESEARCH PROGRAMS AT THE ECOSYSTEMS RESEARCH DIVISION, U.S. ENVIRONMENTAL PROTECTION AGENCY

EPA Science Inventory

This presentation presents information on the research programs at the Ecosystems Research Division (ERD) of the U.S. Environmental Protection Agency located in Athens, Georgia. The presentation gives an overview of the Agency, laws and regulations that the Agency operates under,...

78 FR 28234 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-14

...: Caterina Bianco, MD, Ph.D., Scientific Review Officer, Research Programs Review Branch, Division of... Officer, Research Programs Review Branch, Division of Extramural Activities, National Cancer Institute....396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398, Cancer Research Manpower; 93.399...

Reflections from a Computer Simulations Program on Cell Division in Selected Kenyan Secondary Schools

ERIC Educational Resources Information Center

Ndirangu, Mwangi; Kiboss, Joel K.; Wekesa, Eric W.

2005-01-01

The application of computer technology in education is a relatively new approach that is trying to justify inclusion in the Kenyan school curriculum. Being abstract, with a dynamic nature that does not manifest itself visibly, the process of cell division has posed difficulties for teachers. Consequently, a computer simulation program, using…

Dynamics of cancerous tissue correlates with invasiveness

NASA Astrophysics Data System (ADS)

West, Ann-Katrine Vransø; Wullkopf, Lena; Christensen, Amalie; Leijnse, Natascha; Tarp, Jens Magelund; Mathiesen, Joachim; Erler, Janine Terra; Oddershede, Lene Broeng

2017-03-01

Two of the classical hallmarks of cancer are uncontrolled cell division and tissue invasion, which turn the disease into a systemic, life-threatening condition. Although both processes are studied, a clear correlation between cell division and motility of cancer cells has not been described previously. Here, we experimentally characterize the dynamics of invasive and non-invasive breast cancer tissues using human and murine model systems. The intrinsic tissue velocities, as well as the divergence and vorticity around a dividing cell correlate strongly with the invasive potential of the tissue, thus showing a distinct correlation between tissue dynamics and aggressiveness. We formulate a model which treats the tissue as a visco-elastic continuum. This model provides a valid reproduction of the cancerous tissue dynamics, thus, biological signaling is not needed to explain the observed tissue dynamics. The model returns the characteristic force exerted by an invading cell and reveals a strong correlation between force and invasiveness of breast cancer cells, thus pinpointing the importance of mechanics for cancer invasion.

Internal fluid mechanics research on supercomputers for aerospace propulsion systems

NASA Technical Reports Server (NTRS)

Miller, Brent A.; Anderson, Bernhard H.; Szuch, John R.

1988-01-01

The Internal Fluid Mechanics Division of the NASA Lewis Research Center is combining the key elements of computational fluid dynamics, aerothermodynamic experiments, and advanced computational technology to bring internal computational fluid mechanics (ICFM) to a state of practical application for aerospace propulsion systems. The strategies used to achieve this goal are to: (1) pursue an understanding of flow physics, surface heat transfer, and combustion via analysis and fundamental experiments, (2) incorporate improved understanding of these phenomena into verified 3-D CFD codes, and (3) utilize state-of-the-art computational technology to enhance experimental and CFD research. Presented is an overview of the ICFM program in high-speed propulsion, including work in inlets, turbomachinery, and chemical reacting flows. Ongoing efforts to integrate new computer technologies, such as parallel computing and artificial intelligence, into high-speed aeropropulsion research are described.

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The Chemical Technology (CMT) Division is a diverse technical organization with principal emphases in environmental management and development of advanced energy sources. The Division conducts research and development in three general areas: (1) development of advanced power sources for stationary and transportation applications and for consumer electronics, (2) management of high-level and low-level nuclear wastes and hazardous wastes, and (3) electrometallurgical treatment of spent nuclear fuel. The Division also performs basic research in catalytic chemistry involving molecular energy resources, mechanisms of ion transport in lithium battery electrolytes, and the chemistry of technology-relevant materials and electrified interfaces. In addition, the Divisionmore » operates the Analytical Chemistry Laboratory, which conducts research in analytical chemistry and provides analytical services for programs at Argonne National Laboratory (ANL) and other organizations. Technical highlights of the Division`s activities during 1997 are presented.« less

A History of the Acoustics Division of the Naval Research Laboratory: The First Eight Decades 1923 - 2008

DTIC Science & Technology

2013-08-01

Superintendent” goes back to the early days of NRL in the 1920s and has been retained to the present, refer- ring to the director of each NRL research division...installation, energy for the final amplifiers was stored essentially in the fuel tank of a gas- turbine -driven generator. Signifi- cant research in the Sound...Division found a method for control of the gas turbine which permitted it to supply power in long pulses without damage to the turbine . Research on

Timing the start of division in E. coli: a single-cell study

NASA Astrophysics Data System (ADS)

Reshes, G.; Vanounou, S.; Fishov, I.; Feingold, M.

2008-12-01

We monitor the shape dynamics of individual E. coli cells using time-lapse microscopy together with accurate image analysis. This allows measuring the dynamics of single-cell parameters throughout the cell cycle. In previous work, we have used this approach to characterize the main features of single-cell morphogenesis between successive divisions. Here, we focus on the behavior of the parameters that are related to cell division and study their variation over a population of 30 cells. In particular, we show that the single-cell data for the constriction width dynamics collapse onto a unique curve following appropriate rescaling of the corresponding variables. This suggests the presence of an underlying time scale that determines the rate at which the cell cycle advances in each individual cell. For the case of cell length dynamics a similar rescaling of variables emphasizes the presence of a breakpoint in the growth rate at the time when division starts, τc. We also find that the τc of individual cells is correlated with their generation time, τg, and inversely correlated with the corresponding length at birth, L0. Moreover, the extent of the T-period, τg - τc, is apparently independent of τg. The relations between τc, τg and L0 indicate possible compensation mechanisms that maintain cell length variability at about 10%. Similar behavior was observed for both fast-growing cells in a rich medium (LB) and for slower growth in a minimal medium (M9-glucose). To reveal the molecular mechanisms that lead to the observed organization of the cell cycle, we should further extend our approach to monitor the formation of the divisome.

Flowfield visualization for SSME hot gas manifold

NASA Technical Reports Server (NTRS)

Roger, Robert P.

1988-01-01

The objective of this research, as defined by NASA-Marshall Space Flight Center, was two-fold: (1) to numerically simulate viscous subsonic flow in a proposed elliptical two-duct version of the fuel side Hot Gas Manifold (HGM) for the Space Shuttle Main Engine (SSME), and (2) to provide analytical support for SSME related numerical computational experiments, being performed by the Computational Fluid Dynamics staff in the Aerophysics Division of the Structures and Dynamics Laboratory at NASA-MSFC. Numerical results of HGM were calculations to complement both water flow visualization experiments and air flow visualization experiments and air experiments in two-duct geometries performed at NASA-MSFC and Rocketdyne. In addition, code modification and improvement efforts were to strengthen the CFD capabilities of NASA-MSFC for producing reliable predictions of flow environments within the SSME.

Earth survey applications division: Research leading to the effective use of space technology in applications relating to the Earth's surface and interior

NASA Technical Reports Server (NTRS)

Carpenter, L. (Editor)

1980-01-01

Accomplishments and future plans are described for the following areas: (1) geology - geobotanical indicators and geopotential data; (2) modeling magnetic fields; (3) modeling the structure, composition, and evolution of the Earth's crust; (4) global and regional motions of the Earth's crust and earthquake occurrence; (5) modeling geopotential from satellite tracking data; (6) modeling the Earth's gravity field; (7) global Earth dynamics; (8) sea surface topography, ocean dynamics; and geophysical interpretation; (9) land cover and land use; (10) physical and remote sensing attributes important in detecting, measuring, and monitoring agricultural crops; (11) prelaunch studies using LANDSAT D; (12) the multispectral linear array; (13) the aircraft linear array pushbroom radiometer; and (14) the spaceborne laser ranging system.

Computing the Length of the Shortest Telomere in the Nucleus

NASA Astrophysics Data System (ADS)

Dao Duc, K.; Holcman, D.

2013-11-01

The telomere length can either be shortened or elongated by an enzyme called telomerase after each cell division. Interestingly, the shortest telomere is involved in controlling the ability of a cell to divide. Yet, its dynamics remains elusive. We present here a stochastic approach where we model this dynamics using a Markov jump process. We solve the forward Fokker-Planck equation to obtain the steady state distribution and the statistical moments of telomere lengths. We focus specifically on the shortest one and we estimate its length difference with the second shortest telomere. After extracting key parameters such as elongation and shortening dynamics from experimental data, we compute the length of telomeres in yeast and obtain as a possible prediction the minimum concentration of telomerase required to ensure a proper cell division.

QA RESOURCE MATERIALS TO ASSIST IN DEVELOPING AND WRITING RESEARCH PLANS AT A USEPA OFFICE OF RESEARCH AND DEVELOPMENT DIVISION

EPA Science Inventory

In the process of adapting the Agency's Data Quality Objectives Workshop for presentation at an ORD Research Facility, ownership and consensus approval of the presentation by the Division's research staff was sought. Three groups of researchers, at various levels of responsibilit...

2010-11 Research Portfolio: Research & Development Division

ERIC Educational Resources Information Center

Educational Testing Service, 2010

2010-01-01

This document describes the breadth of the research that the ETS (Educational Testing Service) Research & Development division is conducting in 2010. This portfolio will be updated in early 2011 to reflect changes to existing projects and new projects that were added after this document was completed. The research described in this portfolio falls…

Cell-Division Behavior in a Heterogeneous Swarm Environment.

PubMed

Erskine, Adam; Herrmann, J Michael

2015-01-01

We present a system of virtual particles that interact using simple kinetic rules. It is known that heterogeneous mixtures of particles can produce particularly interesting behaviors. Here we present a two-species three-dimensional swarm in which a behavior emerges that resembles cell division. We show that the dividing behavior exists across a narrow but finite band of parameters and for a wide range of population sizes. When executed in a two-dimensional environment the swarm's characteristics and dynamism manifest differently. In further experiments we show that repeated divisions can occur if the system is extended by a biased equilibrium process to control the split of populations. We propose that this repeated division behavior provides a simple model for cell-division mechanisms and is of interest for the formation of morphological structure and to swarm robotics.

Alignment of cell division axes in directed epithelial cell migration

NASA Astrophysics Data System (ADS)

Marel, Anna-Kristina; Podewitz, Nils; Zorn, Matthias; Oskar Rädler, Joachim; Elgeti, Jens

2014-11-01

Cell division is an essential dynamic event in tissue remodeling during wound healing, cancer and embryogenesis. In collective migration, tensile stresses affect cell shape and polarity, hence, the orientation of the cell division axis is expected to depend on cellular flow patterns. Here, we study the degree of orientation of cell division axes in migrating and resting epithelial cell sheets. We use microstructured channels to create a defined scenario of directed cell invasion and compare this situation to resting but proliferating cell monolayers. In experiments, we find a strong alignment of the axis due to directed flow while resting sheets show very weak global order, but local flow gradients still correlate strongly with the cell division axis. We compare experimental results with a previously published mesoscopic particle based simulation model. Most of the observed effects are reproduced by the simulations.

Instrumentation and Controls Division Overview: Sensors Development for Harsh Environments at Glenn Research Center

NASA Technical Reports Server (NTRS)

Zeller, Mary V.; Lei, Jih-Fen

2002-01-01

The Instrumentation and Controls Division is responsible for planning, conducting and directing basic and applied research on advanced instrumentation and controls technologies for aerospace propulsion and power applications. The Division's advanced research in harsh environment sensors, high temperature high power electronics, MEMS (microelectromechanical systems), nanotechnology, high data rate optical instrumentation, active and intelligent controls, and health monitoring and management will enable self-feeling, self-thinking, self-reconfiguring and self-healing Aerospace Propulsion Systems. These research areas address Agency challenges to deliver aerospace systems with reduced size and weight, and increased functionality and intelligence for future NASA missions in advanced aeronautics, economical space transportation, and pioneering space exploration. The Division also actively supports educational and technology transfer activities aimed at benefiting all humankind.

CV-990 Landing Systems Research Aircraft (LSRA) during final Space Shuttle tire test

NASA Technical Reports Server (NTRS)

1995-01-01

A Convair 990 (CV-990) was used as a Landing Systems Research Aircraft (LSRA) at NASA's Dryden Flight Research Center, Edwards, California, to test space shuttle landing gear and braking systems as part of NASA's effort to upgrade and improve space shuttle capabilities. The first flight at Dryden of the CV-990 with shuttle test components occurred in April 1993, and tests continued into August 1995, when this photo shows a test of the shuttle tires. The purpose of this series of tests was to determine the performance parameters and failure limits of the tires. This particular landing was on the dry lakebed at Edwards, but other tests occurred on the main runway there. The CV-990, built in 1962 by the Convair Division of General Dynamics Corp., Ft. Worth, Texas, served as a research aircraft at Ames Research Center, Moffett Field, California, before it came to Dryden.

Materials Division research and technology accomplishments for FY 87 and plans for FY 88

NASA Technical Reports Server (NTRS)

Brinkley, Kay L.

1988-01-01

The research program of the Materials Division is presented as FY 87 accomplishments and FY 88 plans. The accomplishments for each Branch are highlighted and plans are outlined. Publications of the Division are included by Branch. This material will be useful in program coordination with other government organizations, universities, and industries in areas of mutual interest.

Materials Division research and technology accomplishments for FY 89 and plans for FY 90

NASA Technical Reports Server (NTRS)

Brinkley, Kay L.

1990-01-01

The research program of the Materials Division is presented as FY-89 accomplishments and FY-90 plans. The accomplishments for each Branch are highlighted and plans are outlined. Publications of the Division are included by Branch. This material will be useful in program coordination with other government organizations, universities, and industries in areas of mutual interest.

Materials Division research and technical accomplishments for FY 1988 and plans for FY 1989

NASA Technical Reports Server (NTRS)

Brinkley, Kay L.

1989-01-01

The research program of the Materials Division is presented as FY-88 accomplishments and FY-89 plans. The accomplishments for each Branch are highlighted and plans are outlined. Publications of the Division are included by Branch. This material is useful in program coordination with other government organizations, universities, and industry in areas of mutual interest.

Berkeley Lab - Materials Sciences Division

Science.gov Websites

Postdoc Forum Research Highlights Awards Publications Database Events Calendar Newsletter Archive People ; Finance Templates Travel One-Stop Investigators Division Staff Facilities and Centers Staff Jobs People Division, please use the links here. An outline of the Division structure is available at the Organization

7 CFR 2003.26 - Functional organization of RBS.

Code of Federal Regulations, 2011 CFR

2011-01-01

... on cooperative marketing. The division conducts research and analysis and gives technical assistance... cooperative resource management. The division conducts research and analysis and gives technical assistance to... service to cooperative associations by administering a program of research and analysis of economic...

Research and technology activities at Ames Research Center's Biomedical Research Division

NASA Technical Reports Server (NTRS)

Martello, N.

1985-01-01

Various research and technology activities at Ames Research Center's Biomedical Research Division are described. Contributions to the Space Administration's goals in the life sciences include descriptions of research in operational medicine, cardiovascular deconditioning, motion sickness, bone alterations, muscle atrophy, fluid and electrolyte changes, radiation effects and protection, behavior and performance, gravitational biology, and life sciences flight experiments.

Solar Dynamics Observatory Briefing

NASA Image and Video Library

2010-01-21

Richard Fisher, Heliophysics Division Director at NASA Headquarters, left, speaks during a briefing to discuss the upcoming launch of NASA's Solar Dynamic Observatory, or SDO, Thursday, Jan. 21, 2010, as Madhulika Guhathakurta, SDO Program Scientist looks on at NASA Headquarters in Washington. The mission is to study the Sun and its dynamic behavior. Photo Credit: (NASA/Paul E. Alers)

Dynamic divisive normalization predicts time-varying value coding in decision-related circuits.

PubMed

Louie, Kenway; LoFaro, Thomas; Webb, Ryan; Glimcher, Paul W

2014-11-26

Normalization is a widespread neural computation, mediating divisive gain control in sensory processing and implementing a context-dependent value code in decision-related frontal and parietal cortices. Although decision-making is a dynamic process with complex temporal characteristics, most models of normalization are time-independent and little is known about the dynamic interaction of normalization and choice. Here, we show that a simple differential equation model of normalization explains the characteristic phasic-sustained pattern of cortical decision activity and predicts specific normalization dynamics: value coding during initial transients, time-varying value modulation, and delayed onset of contextual information. Empirically, we observe these predicted dynamics in saccade-related neurons in monkey lateral intraparietal cortex. Furthermore, such models naturally incorporate a time-weighted average of past activity, implementing an intrinsic reference-dependence in value coding. These results suggest that a single network mechanism can explain both transient and sustained decision activity, emphasizing the importance of a dynamic view of normalization in neural coding. Copyright © 2014 the authors 0270-6474/14/3416046-12$15.00/0.

Three-dimensional patterns of cell division and expansion throughout the development of Arabidopsis thaliana leaves.

PubMed

Kalve, Shweta; Fotschki, Joanna; Beeckman, Tom; Vissenberg, Kris; Beemster, Gerrit T S

2014-12-01

Variations in size and shape of multicellular organs depend on spatio-temporal regulation of cell division and expansion. Here, cell division and expansion rates were quantified relative to the three spatial axes in the first leaf pair of Arabidopsis thaliana. The results show striking differences in expansion rates: the expansion rate in the petiole is higher than in the leaf blade; expansion rates in the lateral direction are higher than longitudinal rates between 5 and 10 days after stratification, but become equal at later stages of leaf blade development; and anticlinal expansion co-occurs with, but is an order of magnitude slower than periclinal expansion. Anticlinal expansion rates also differed greatly between tissues: the highest rates occurred in the spongy mesophyll and the lowest in the epidermis. Cell division rates were higher and continued for longer in the epidermis compared with the palisade mesophyll, causing a larger increase of palisade than epidermal cell area over the course of leaf development. The cellular dynamics underlying the effect of shading on petiole length and leaf thickness were then investigated. Low light reduced leaf expansion rates, which was partly compensated by increased duration of the growth phase. Inversely, shading enhanced expansion rates in the petiole, so that the blade to petiole ratio was reduced by 50%. Low light reduced leaf thickness by inhibiting anticlinal cell expansion rates. This effect on cell expansion was preceded by an effect on cell division, leading to one less layer of palisade cells. The two effects could be uncoupled by shifting plants to contrasting light conditions immediately after germination. This extended kinematic analysis maps the spatial and temporal heterogeneity of cell division and expansion, providing a framework for further research to understand the molecular regulatory mechanisms involved. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Nitric acid poisoning

MedlinePlus

... Board on Environmental Studies and Toxicology; Division on Earth and Life Studies; National Research Council. Nitric acid: ... Board on Environmental Studies and Toxicology; Division on Earth and Life Studies; National Research Council. Acute Exposure ...

Assessing the Added Value of Dynamical Downscaling Using ...

EPA Pesticide Factsheets

In this study, the Standardized Precipitation Index (SPI) is used to ascertain the added value of dynamical downscaling over the contiguous United States. WRF is used as a regional climate model (RCM) to dynamically downscale reanalysis fields to compare values of SPI over drought timescales that have implications for agriculture and water resources planning. The regional climate generated by WRF has the largest improvement over reanalysis for SPI correlation with observations as the drought timescale increases. This suggests that dynamically downscaled fields may be more reliable than larger-scale fields for water resource applications (e.g., water storage within reservoirs). WRF improves the timing and intensity of moderate to extreme wet and dry periods, even in regions with homogenous terrain. This study also examines changes in SPI from the extreme drought of 1988 and three “drought busting” tropical storms. Each of those events illustrates the importance of using downscaling to resolve the spatial extent of droughts. The analysis of the “drought busting” tropical storms demonstrates that while the impact of these storms on ending prolonged droughts is improved by the RCM relative to the reanalysis, it remains underestimated. These results illustrate the importance and some limitations of using RCMs to project drought. The National Exposure Research Laboratory’s Atmospheric Modeling Division (AMAD) conducts research in support of EPA’s mission t

Program report for FY 1984 and 1985 Atmospheric and Geophysical Sciences Division of the Physics Department

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knox, J.B.; MacCracken, M.C.; Dickerson, M.H.

1986-08-01

This annual report for the Atmospheric and Geophysical Sciences Division (G-Division) summarizes the activities and highlights of the past three years, with emphasis on significant research findings in two major program areas: the Atmospheric Release Advisory Capability (ARAC), with its recent involvement in assessing the effects of the Chernobyl reactor accident, and new findings on the environmental consequences of nuclear war. The technical highlights of the many other research projects are also briefly reported, along with the Division's organization, budget, and publications.

Metals and Ceramics Division progress report for period ending December 31, 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Craig, D.F.; Weir, J.R. Jr.

1993-04-01

This report provides a brief overview of the activities and accomplishments of the division, whose purpose is to provide technical support, primarily in the area of high-temperature materials, for the various technologies being developed by US DOE. Activities range from basic research to industrial research and technology transfer. The division (and the report) is divided into the following: Engineering materials, high-temperature materials, materials science, ceramics, nuclear fuel materials, program activities, collaborative research facilities and technology transfer, and educational programs.

Should Reproductive Anatomy Be Taught in University Health Courses?

ERIC Educational Resources Information Center

Powell, Brent; Fletcher, J. Sue

2013-01-01

There has been little research on undergraduate reproductive anatomy education. This pilot study explores knowledge of anatomical reproductive anatomy among university students in a lower division and upper division health course. Using a Qualtrics survey program, a convenience sample of 120 lower division and 157 upper division students for a…

78 FR 35982 - Meetings of Humanities Panel

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-14

... History, Social Science, and Education, submitted to the Division of Research Programs. 5. Date: July 17..., Anthropology, Psychology, and History of Science, submitted to the Division of Research Programs. 11. Date...

NCI: DCTD: Biometric Research Branch

Cancer.gov

The Biometric Research Branch (BRP) is the statistical and biomathematical component of the Division of Cancer Treatment, Diagnosis and Centers (DCTDC). Its members provide statistical leadership for the national and international research programs of the division in developmental therapeutics, developmental diagnostics, diagnostic imaging and clinical trials.

NCI: DCTD: Biometric Research Program

Cancer.gov

The Biometric Research Program (BRP) is the statistical and biomathematical component of the Division of Cancer Treatment, Diagnosis and Centers (DCTDC). Its members provide statistical leadership for the national and international research programs of the division in developmental therapeutics, developmental diagnostics, diagnostic imaging and clinical trials.

NCI: DCTD: Biometric Research Branch

Cancer.gov

The Biometric Research Branch (BRB) is the statistical and biomathematical component of the Division of Cancer Treatment, Diagnosis and Centers (DCTDC). Its members provide statistical leadership for the national and international research programs of the division in developmental therapeutics, developmental diagnostics, diagnostic imaging and clinical trials.

NCI: DCTD: Biometric Research Program

Cancer.gov

The Biometric Research Program (BRB) is the statistical and biomathematical component of the Division of Cancer Treatment, Diagnosis and Centers (DCTDC). Its members provide statistical leadership for the national and international research programs of the division in developmental therapeutics, developmental diagnostics, diagnostic imaging and clinical trials.

History-Based Response Threshold Model for Division of Labor in Multi-Agent Systems

PubMed Central

Lee, Wonki; Kim, DaeEun

2017-01-01

Dynamic task allocation is a necessity in a group of robots. Each member should decide its own task such that it is most commensurate with its current state in the overall system. In this work, the response threshold model is applied to a dynamic foraging task. Each robot employs a task switching function based on the local task demand obtained from the surrounding environment, and no communication occurs between the robots. Each individual member has a constant-sized task demand history that reflects the global demand. In addition, it has response threshold values for all of the tasks and manages the task switching process depending on the stimuli of the task demands. The robot then determines the task to be executed to regulate the overall division of labor. This task selection induces a specialized tendency for performing a specific task and regulates the division of labor. In particular, maintaining a history of the task demands is very effective for the dynamic foraging task. Various experiments are performed using a simulation with multiple robots, and the results show that the proposed algorithm is more effective as compared to the conventional model. PMID:28555031

Alpha status, dominance, leadership, and division of labor in wolf packs

USGS Publications Warehouse

Mech, L. David

1999-01-01

The prevailing view of a wolf (Canis lupus) pack is that of a group of individuals ever vying for dominance but held in check by the "alpha" pair, the alpha male and alpha female. Most research on the social dynamics of wolf packs, however, has been conducted on non-natural assortments of captive wolves. Here I describe the wolf-pack social order as it occurs in nature, discuss the alpha concept and social dominance and submission, and present data on the precise relationships among members in free-living packs, based on a literature review and 13 summers of observations of wolves on Ellesmere Island, Northwest Territories, Canada. I conclude that the typical wolf pack is a family, with the adult parents guiding the activities of the group in a division-of-labor system in which the female predominates primarily in such activities as pup care and defense and the male primarily during foraging and food-provisioning and the travels associated with them.

BioClips of symmetric and asymmetric cell division.

PubMed

Lu, Fong-Mei; Eliceiri, Kevin W; White, John G

2007-05-01

Animations have long been used as tools to illustrate complex processes in such diverse fields as mechanical engineering, astronomy, bacteriology and physics. Animations in biology hold particular educational promise for depicting complex dynamic processes, such as photosynthesis, motility, viral replication and cellular respiration, which cannot be easily explained using static two-dimensional images. However, these animations have often been restrictive in scope, having been created for a specific classroom or research audience. In recent years, a new type of animation has emerged called the BioClip (http://www.bioclips.com) that strives to present science in an interactive multimedia format, which is, at once, informative and entertaining, by combining animations, text descriptions and music in one portable cross-platform document. In the present article, we illustrate the educational value of this new electronic resource by reviewing in depth two BioClips our group has created which describe the processes of symmetric and asymmetric cell division (http://www.wormclassroom.org/cb/bioclip).

NASA Earth Science Partnerships - A Multi-Level Approach to Effectively Collaborating with Communities and Organizations to Utilize Earth Science Data for Societal Benefit

NASA Astrophysics Data System (ADS)

Favors, J.

2016-12-01

NASA's Earth Science Division (ESD) seeks to develop a scientific understanding of the Earth as a dynamic, integrated system of diverse components that interact in complex ways - analogous to the human body. The Division approaches this goal through a coordinated series of satellite and airborne missions, sponsored basic and applied research, technology development, and science education. Integral to this approach are strong collaborations and partnerships with a spectrum of organizations that produce substantive benefit to communities - both locally and globally. This presentation will showcase various ways ESD approaches partnering and will highlight best practices, challenges, and provide case studies related to rapid partnerships, co-location of scientists and end-user communities, capacity building, and ESD's new Partnerships Program which is built around taking an innovative approach to partnering that fosters interdisplinary teaming & co-production of knowledge to broaden the applicability of Earth observations and answer new, big questions for partners and NASA, alike.

Evolutionary dynamics of division of labor games with selfish agents

NASA Astrophysics Data System (ADS)

Zhang, Jianlei; Li, Qiaoyu; Zhang, Chunyan

2017-11-01

The division of labor is one of the most basic and widely studied aspects of collective behavior in natural systems. Studies of division of labor are concerned with the integration of the individual worker behavior into a colony level task organization and with the question of how the regulation of the division of labor may contribute to the colony efficiency. This paper investigates the evolution of the division of labor with three strategies by employing the evolutionary game theory. Thus, these available strategies are, respectively, strategy A (performing task A), strategy B (performing task B), and strategy D (not performing any task but only free riding others' contributions). And, two typical networks (i.e., BA scale-free network and lattice network) are employed here for describing the interaction structure among agents. The theoretical analysis together with simulation results reveal that the division of labor can evolve and leads to players that differ in their tendency to take on a given task. The conditions under which the division of labor evolves depend on the costs for performing the task, the benefits led by performing the task, and the interaction structures among the players who are involved with division of labor games.

Metals and Ceramics Division progress report for period ending December 31, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Craig, D.F.; Bradley, R.A.; Weir, J.R. Jr.

1994-07-01

This report provides an overview of activities and accomplishsments of the division from October 1992 through December 1993; the division is organized to provide technical support, mainly in the area of high-temperature materials, for technologies being developed by DOE. Activities span the range from basic research to industrial interactions (cooperative research and technology transfer). Sections 1-5 describe the different functional groups (engineering materials, high-temperature materials, materials science, ceramics, nuclear fuel materials). Sect. 6 provides an alternative view of the division in terms of the major programs, most of which cross group lines. Sect. 7 summarizes external interactions including cooperative Rmore » and D programs and technology transfer functions. Finally, Sect. 8 briefly describes the division`s involvement in educational activities. Several organizational changes were effected during this period.« less

Website for the Space Science Division

NASA Technical Reports Server (NTRS)

Schilling, James; DeVincenzi, Donald (Technical Monitor)

2002-01-01

The Space Science Division at NASA Ames Research Center is dedicated to research in astrophysics, exobiology, advanced life support technologies, and planetary science. These research programs are structured around Astrobiology (the study of life in the universe and the chemical and physical forces and adaptions that influence life's origin, evolution, and destiny), and address some of the most fundamental questions pursued by science. These questions examine the origin of life and our place in the universe. Ames is recognized as a world leader in Astrobiology. In pursuing our mission in Astrobiology, Space Science Division scientists perform pioneering basic research and technology development.

Berkeley Lab - Materials Sciences Division

Science.gov Websites

sponsors. Distinguish by scope/specific aspects of research; or by institution; or by individual. Example Sciences Division About Organization Contact Research Core Programs Materials Discovery, Design and Postdoc Forum Research Highlights Awards Publications Database Events Calendar Newsletter Archive People

RESEARCH AND TECHNOLOGY DIVISION REPORT FOR 1966.

ERIC Educational Resources Information Center

BAUM, C.

THE WORK OF THE RESEARCH AND TECHNOLOGY DIVISION OF SYSTEM DEVELOPMENT CORPORATION DURING 1966 IS REPORTED. THE PROGRESS OF VARIOUS STUDIES AND ACTIVITIES DISCUSSED IN THE REPORT WERE ADVANCED PROGRAMING, INFORMATION PROCESSING RESEARCH, PROGRAMING SYSTEMS, DATA BASE SYSTEMS. LANGUAGE PROCESSING AND RETRIEVAL, BEHAVIORAL GAMING AND SIMULATION…

Distinct temporal requirements for autophagy and the proteasome in yeast meiosis

PubMed Central

Wen, Fu-Ping; Guo, Yue-Shuai; Hu, Yang; Liu, Wei-Xiao; Wang, Qian; Wang, Yuan-Ting; Yu, Hai-Yan; Tang, Chao-Ming; Yang, Jun; Zhou, Tao; Xie, Zhi-Ping; Sha, Jia-Hao; Guo, Xuejiang; Li, Wei

2016-01-01

ABSTRACT Meiosis is a special type of cellular renovation that involves 2 successive cell divisions and a single round of DNA replication. Two major degradation systems, the autophagy-lysosome and the ubiquitin-proteasome, are involved in meiosis, but their roles have yet to be elucidated. Here we show that autophagy mainly affects the initiation of meiosis but not the nuclear division. Autophagy works not only by serving as a dynamic recycling system but also by eliminating some negative meiotic regulators such as Ego4 (Ynr034w-a). In a quantitative proteomics study, the proteasome was found to be significantly upregulated during meiotic divisions. We found that proteasomal activity is essential to the 2 successive meiotic nuclear divisions but not for the initiation of meiosis. Our study defines the roles of autophagy and the proteasome in meiosis: Autophagy mainly affects the initiation of meiosis, whereas the proteasome mainly affects the 2 successive meiotic divisions. PMID:27050457

Distinct temporal requirements for autophagy and the proteasome in yeast meiosis.

PubMed

Wen, Fu-ping; Guo, Yue-shuai; Hu, Yang; Liu, Wei-xiao; Wang, Qian; Wang, Yuan-ting; Yu, Hai-Yan; Tang, Chao-ming; Yang, Jun; Zhou, Tao; Xie, Zhi-ping; Sha, Jia-hao; Guo, Xuejiang; Li, Wei

2016-01-01

Meiosis is a special type of cellular renovation that involves 2 successive cell divisions and a single round of DNA replication. Two major degradation systems, the autophagy-lysosome and the ubiquitin-proteasome, are involved in meiosis, but their roles have yet to be elucidated. Here we show that autophagy mainly affects the initiation of meiosis but not the nuclear division. Autophagy works not only by serving as a dynamic recycling system but also by eliminating some negative meiotic regulators such as Ego4 (Ynr034w-a). In a quantitative proteomics study, the proteasome was found to be significantly upregulated during meiotic divisions. We found that proteasomal activity is essential to the 2 successive meiotic nuclear divisions but not for the initiation of meiosis. Our study defines the roles of autophagy and the proteasome in meiosis: Autophagy mainly affects the initiation of meiosis, whereas the proteasome mainly affects the 2 successive meiotic divisions.

The Nexus for Exoplanet System Science

NASA Technical Reports Server (NTRS)

Batalha, Natalie Marie; Gelino, Dawn; Del Genio, Tony

2016-01-01

NExSS is a research coordination network dedicated to the study of planetary habitability. A NASA cross-division initiative bringing astrophysicists, planetary scientists, Earth scientists, and heliophysicists together to bring a systems science approach to this problem. NExSS's goals being to investigate the diversity of planets, understanding how planet history, geology, and climate interact to create the conditions for life. Also, to put planets into an architectural context as stellar systems built over time by dynamical processes and sculpted by stars. Use experience from solar system (including Earth) history to identify where habitable niches are most likely to occur and which planets are most likely to be habitable. Leverage NASA investments in research and missions to accelerate discovery and characterization of potential life-bearing worlds.

Data collection procedures for the Software Engineering Laboratory (SEL) database

NASA Technical Reports Server (NTRS)

Heller, Gerard; Valett, Jon; Wild, Mary

1992-01-01

This document is a guidebook to collecting software engineering data on software development and maintenance efforts, as practiced in the Software Engineering Laboratory (SEL). It supersedes the document entitled Data Collection Procedures for the Rehosted SEL Database, number SEL-87-008 in the SEL series, which was published in October 1987. It presents procedures to be followed on software development and maintenance projects in the Flight Dynamics Division (FDD) of Goddard Space Flight Center (GSFC) for collecting data in support of SEL software engineering research activities. These procedures include detailed instructions for the completion and submission of SEL data collection forms.

Solid-State Division progress report for period ending March 31, 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, P.H.; Watson, D.M.

1983-09-01

Progress and activities are reported on: theoretical solid-state physics (surfaces; electronic, vibrational, and magnetic properties; particle-solid interactions; laser annealing), surface and near-surface properties of solids (surface, plasma-material interactions, ion implantation and ion-beam mixing, pulsed-laser and thermal processing), defects in solids (radiation effects, fracture, impurities and defects, semiconductor physics and photovoltaic conversion), transport properties of solids (fast-ion conductors, superconductivity, mass and charge transport in materials), neutron scattering (small-angle scattering, lattice dynamics, magnetic properties, structure and instrumentation), and preparation and characterization of research materials (growth and preparative methods, nuclear waste forms, special materials). (DLC)

An auxiliary graph based dynamic traffic grooming algorithm in spatial division multiplexing enabled elastic optical networks with multi-core fibers

NASA Astrophysics Data System (ADS)

Zhao, Yongli; Tian, Rui; Yu, Xiaosong; Zhang, Jiawei; Zhang, Jie

2017-03-01

A proper traffic grooming strategy in dynamic optical networks can improve the utilization of bandwidth resources. An auxiliary graph (AG) is designed to solve the traffic grooming problem under a dynamic traffic scenario in spatial division multiplexing enabled elastic optical networks (SDM-EON) with multi-core fibers. Five traffic grooming policies achieved by adjusting the edge weights of an AG are proposed and evaluated through simulation: maximal electrical grooming (MEG), maximal optical grooming (MOG), maximal SDM grooming (MSG), minimize virtual hops (MVH), and minimize physical hops (MPH). Numeric results show that each traffic grooming policy has its own features. Among different traffic grooming policies, an MPH policy can achieve the lowest bandwidth blocking ratio, MEG can save the most transponders, and MSG can obtain the fewest cores for each request.

76 FR 27563 - Margin and Capital Requirements for Covered Swap Entities

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

.... Board: Sean D. Campbell, Deputy Associate Director, Division of Research and Statistics, (202) 452-3761, Michael Gibson, Senior Associate Director, Division of Research and Statistics, (202) 452- 2495, or Jeremy..., DC 20429. FHFA: Robert Collender, Principal Policy Analyst, Office of Policy Analysis and Research...

RESEARCH ACTIVITIES AT THE US EPA'S GULF ECOLOGY DIVISION

EPA Science Inventory

The purpose of this talk was to present an overview of research activities at the US EPA's Office of Research and Development, Gulf Ecology Division located on Pensacola Beach, Florida. The talk was organized into three major sections. The first section covered my educational b...

21 CFR 312.48 - Dispute resolution.

Code of Federal Regulations, 2010 CFR

2010-04-01

... division in FDA's Center for Drug Evaluation and Research or Center for Biologics Evaluation and Research which is responsible for review of the IND, beginning with the consumer safety officer assigned to the... director of the division in FDA's Center for Drug Evaluation and Research or Center for Biologics...

NASA. Lewis Research Center materials research and technology: An overview

NASA Technical Reports Server (NTRS)

Grisaffe, Salvatore J.

1990-01-01

The Materials Division at the Lewis Research Center has a long record of contributions to both materials and process technology as well as to the understanding of key high-temperature phenomena. This paper overviews the division staff, facilities, past history, recent progress, and future interests.

The mechanisms of labor division from the perspective of individual optimization

NASA Astrophysics Data System (ADS)

Zhu, Lirong; Chen, Jiawei; Di, Zengru; Chen, Liujun; Liu, Yan; Stanley, H. Eugene

2017-12-01

Although the tools of complexity research have been applied to the phenomenon of labor division, its underlying mechanisms are still unclear. Researchers have used evolutionary models to study labor division in terms of global optimization, but focusing on individual optimization is a more realistic, real-world approach. We do this by first developing a multi-agent model that takes into account information-sharing and learning-by-doing and by using simulations to demonstrate the emergence of labor division. We then use a master equation method and find that the computational results are consistent with the results of the simulation. Finally we find that the core underlying mechanisms that cause labor division are learning-by-doing, information cost, and random fluctuation.

About the Western Ecology Division (WED) of EPA's National Health and Environmental Effects Research Laboratory

EPA Pesticide Factsheets

The Western Ecology Division (WED) conducts innovative research on watershed ecological epidemiology and the development of tools to achieve sustainable and resilient watersheds for application by stakeholders.

2005 annual progress report: Elk and bison grazing ecology in the Great Sand Dunes complex of lands

USGS Publications Warehouse

Schoenecker, Kate A.; Lubow, Bruce C.; Zeigenfuss, Linda C.; Mao, Julie

2006-01-01

To address the questions and needs of local resource managers, a multi-agency research project was initiated in 2005 to study the ecology, forage relations, and habitat relations of elk and bison in the Great Sand Dunes–Sangre de Cristo–Baca complex of lands. Meetings and discussions of what this research should include were started in 2001 with representatives from NPS, USFWS, TNC, the Colorado Division of Wildlife (CDOW), and USDA-FS/BLM. The final study plan was successfully funded in 2004 with research scheduled to start in 2005. The research was designed to encompass three major study elements: (1) animal movements and population dynamics, (2) vegetation and nutrient effects from ungulate herbivory, and (3) development of ecological models, using empirical data collected from the first two components, that will include estimates of elk carrying capacity and management scenarios for resource managers.

The Optimal Allocation of Army Enlistment Incentives by MOS; Analyses of CY 86-87 Experience, Impacts of Nonmonetary Guidance Counselor Incentives, and PC Software

DTIC Science & Technology

1989-05-01

0 ELECTE VARSHA P. RAO SEP11190 AND U DONNA ROBERTS MAY 1989 APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED O Research & Studies Division U.S...DAKF 15-87-0-0144 Subcontract Sub-Hi 88-12, Do No. 88-007, with the Research and Studies Division, Program Analysis and Evaluation Directorate of...Toomepuu, Chief, Research and Studies Division, for their helpful counsel. ii TABLE OF CONTENTS PAGE DISCLAIMER ii ACKNOWLEDGMENTS ii LIST OF FIGURES v

Dependence within Families and the Division of Labor: Comparing Sweden and the United States

ERIC Educational Resources Information Center

Evertsson, Marie; Nermo, Magnus

2004-01-01

This article assesses the relative explanatory value of the resource-bargaining perspective and the doing-gender approach for the division of housework in the United States and Sweden from the mid-1970s to 2000. The data used are the Panel Study of Income Dynamics (PSID) and the Swedish Level of Living Survey. Overall results show that housework…

Static and Dynamic Human Shape Modeling - A Review of the Literature and State of the Art

DTIC Science & Technology

2009-04-01

Figure 60. Confluent marker-based animation (Aguiar et al. 2006). Subsequent frames showing the female scan authentically performing a soccer kick ...Infoscitex Corp. 4027 Colonel Glenn Highway Suite 210 Dayton OH 45431-1672 Kathleen Robinette Biosciences and Protection Division Biomechanics ...Biosciences and Protection Division Biomechanics Branch Wright-Patterson AFB OH 45433 Approved for public release; distribution unlimited. NOTICE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Craig, D.F.

The division was formed in 1946 at the suggestion of Dr. Eugene P. Wigner to attack the problem of the distortion of graphite in the early reactors due to exposure to reactor neutrons, and the consequent radiation damage. It was called the Metallurgy Division and assembled the metallurgical and solid state physics activities of the time which were not directly related to nuclear weapons production. William A. Johnson, a Westinghouse employee, was named Division Director in 1946. In 1949 he was replaced by John H Frye Jr. when the Division consisted of 45 people. He was director during most ofmore » what is called the Reactor Project Years until 1973 and his retirement. During this period the Division evolved into three organizational areas: basic research, applied research in nuclear reactor materials, and reactor programs directly related to a specific reactor(s) being designed or built. The Division (Metals and Ceramics) consisted of 204 staff members in 1973 when James R. Weir, Jr., became Director. This was the period of the oil embargo, the formation of the Energy Research and Development Administration (ERDA) by combining the Atomic Energy Commission (AEC) with the Office of Coal Research, and subsequent formation of the Department of Energy (DOE). The diversification process continued when James O. Stiegler became Director in 1984, partially as a result of the pressure of legislation encouraging the national laboratories to work with U.S. industries on their problems. During that time the Division staff grew from 265 to 330. Douglas F. Craig became Director in 1992.« less

Supercharger Research at the Aircraft Engine Research Laboratory

NASA Image and Video Library

1944-01-21

A researcher in the Supercharger Research Division at the National Advisory Committee for Aeronautics (NACA) Aircraft Engine Research Laboratory measures the blade thickness on a supercharger. Superchargers were developed at General Electric used to supply additional air to reciprocating engines. The extra air resulted in increased the engine’s performance, particularly at higher altitudes. The Aircraft Engine Research Laboratory had an entire division dedicated to superchargers during World War II. General Electric developed the supercharger in response to a 1917 request from the NACA to develop a device to enhance high-altitude flying. The supercharger pushed larger volumes of air into the engine manifold. The extra oxygen allowed the engine to operate at its optimal sea-level rating even when at high altitudes. Thus, the aircraft could maintain its climb rate, maneuverability and speed as it rose higher into the sky. NACA work on the supercharger ceased after World War II due to the arrival of the turbojet engine. The Supercharger Research Division was disbanded in October 1945 and reconstituted as the Compressor and Turbine Division.

Acoustics Division recent accomplishments and research plans

NASA Technical Reports Server (NTRS)

Clark, L. R.; Morgan, H. G.

1986-01-01

The research program currently being implemented by the Acoustics Division of NASA Langley Research Center is described. The scope, focus, and thrusts of the research are discussed and illustrated for each technical area by examples of recent technical accomplishments. Included is a list of publications for the last two calendar years. The organization, staff, and facilities are also briefly described.

How PI3K-derived lipids control cell division.

PubMed

Campa, Carlo C; Martini, Miriam; De Santis, Maria C; Hirsch, Emilio

2015-01-01

To succeed in cell division, intense cytoskeletal and membrane remodeling are required to allow accurate chromosome segregation and cytoplasm partitioning. Spatial restriction of the actin dynamics and vesicle trafficking define the cell symmetry and equivalent membrane scission events, respectively. Protein complexes coordinating mitosis are recruited to membrane microdomains characterized by the presence of the phosphatidylinositol lipid members (PtdIns), like PtdIns(3,4,5)P 3,PtdIns(4,5)P 2, and PtdIns(3)P. These PtdIns represent a minor component of cell membranes, defining membrane domain identity, ultimately controlling cytoskeleton and membrane dynamics during mitosis. The coordinated presence of PtdIns(3,4,5)P 3 at the cell poles and PtdIns(4,5)P 2 at the cleavage furrow controls the polarity of the actin cytoskeleton leading to symmetrical cell division. In the endosomal compartment, the trafficking of PtdIns(3)P positive vesicles allows the recruitment of the protein machinery required for the abscission.

Real-time tracking of cell cycle progression during CD8+ effector and memory T-cell differentiation

PubMed Central

Kinjyo, Ichiko; Qin, Jim; Tan, Sioh-Yang; Wellard, Cameron J.; Mrass, Paulus; Ritchie, William; Doi, Atsushi; Cavanagh, Lois L.; Tomura, Michio; Sakaue-Sawano, Asako; Kanagawa, Osami; Miyawaki, Atsushi; Hodgkin, Philip D.; Weninger, Wolfgang

2015-01-01

The precise pathways of memory T-cell differentiation are incompletely understood. Here we exploit transgenic mice expressing fluorescent cell cycle indicators to longitudinally track the division dynamics of individual CD8+ T cells. During influenza virus infection in vivo, naive T cells enter a CD62Lintermediate state of fast proliferation, which continues for at least nine generations. At the peak of the anti-viral immune response, a subpopulation of these cells markedly reduces their cycling speed and acquires a CD62Lhi central memory cell phenotype. Construction of T-cell family division trees in vitro reveals two patterns of proliferation dynamics. While cells initially divide rapidly with moderate stochastic variations of cycling times after each generation, a slow-cycling subpopulation displaying a CD62Lhi memory phenotype appears after eight divisions. Phenotype and cell cycle duration are inherited by the progeny of slow cyclers. We propose that memory precursors cell-intrinsically modulate their proliferative activity to diversify differentiation pathways. PMID:25709008

Real-time tracking of cell cycle progression during CD8+ effector and memory T-cell differentiation.

PubMed

Kinjyo, Ichiko; Qin, Jim; Tan, Sioh-Yang; Wellard, Cameron J; Mrass, Paulus; Ritchie, William; Doi, Atsushi; Cavanagh, Lois L; Tomura, Michio; Sakaue-Sawano, Asako; Kanagawa, Osami; Miyawaki, Atsushi; Hodgkin, Philip D; Weninger, Wolfgang

2015-02-24

The precise pathways of memory T-cell differentiation are incompletely understood. Here we exploit transgenic mice expressing fluorescent cell cycle indicators to longitudinally track the division dynamics of individual CD8(+) T cells. During influenza virus infection in vivo, naive T cells enter a CD62L(intermediate) state of fast proliferation, which continues for at least nine generations. At the peak of the anti-viral immune response, a subpopulation of these cells markedly reduces their cycling speed and acquires a CD62L(hi) central memory cell phenotype. Construction of T-cell family division trees in vitro reveals two patterns of proliferation dynamics. While cells initially divide rapidly with moderate stochastic variations of cycling times after each generation, a slow-cycling subpopulation displaying a CD62L(hi) memory phenotype appears after eight divisions. Phenotype and cell cycle duration are inherited by the progeny of slow cyclers. We propose that memory precursors cell-intrinsically modulate their proliferative activity to diversify differentiation pathways.

Dr. Worta McCaskill-Stevens Named Recipient of AACR Minorities in Cancer Research Award | Division of Cancer Prevention

Cancer.gov

Worta McCaskill-Stevens, MD, MS, Chief of the Community Oncology and Prevention Trials Research Group, NCI Division of Cancer Prevention, was named the recipient of the 2016 American Association for Cancer Research Jane Cooke Wright Memorial Lectureship. |

78 FR 50065 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-16

... Methodological Research for Cancer Epidemiology Cohorts. Date: October 25, 2013. Time: 10:30 a.m. to 2:30 p.m... Lopaczynski, MD, Ph.D., Scientific Review Officer, Research Programs Review Branch, Division of Extramural.... Contact Person: Shakeel Ahmad, Ph.D., Scientific Review Officer, Research Programs Review Branch, Division...

RESEARCH AREA -- ARTIFICIAL INTELLIGENCE CONTROL (AIR POLLUTION TECHNOLOGY BRANCH, AIR POLLUTION PREVENTION AND CONTROL DIVISION, NRMRL)

EPA Science Inventory

The Air Pollution Technology Branch (APTB) of NRMRL's Air Pollution Prevention and Control Division in Research Triangle Park, NC, has conducted several research projects for evaluating the use of artificial intelligence (AI) to improve the control of pollution control systems an...

Psychological Sciences Division: 1985 Programs.

ERIC Educational Resources Information Center

Office of Naval Research, Washington, DC. Psychological Sciences Div.

This booklet describes research carried out under sponsorship of the Psychological Sciences Division of the U.S. Office of Naval Research during Fiscal Year 1985. The booklet is divided into three programmatic research areas: (1) Engineering Psychology; (2) Personnel and Training; and (3) Group Psychology. Each program is described by an overview…

77 FR 8268 - National Institute of Neurological Disorders and Stroke Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-14

... Branch, Division of Extramural Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite... Officer, Scientific Review Branch, Division of Extramural Research, NINDS/NIH/DHHS/Neuroscience Center... Disorders; 93.854, Biological Basis Research in the Neurosciences, National Institutes of Health, HHS) Dated...

78 FR 26379 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-06

... Methodological Research for Cancer Epidemiology Cohorts. Date: June 25, 2013. Time: 11:00 a.m. to 4:00 p.m... Officer, Research Programs Review Branch, Division of Extramural Activities, National Cancer Institute... Person: David G. Ransom, Ph.D., Scientific Review Officer, Research Programs Review Branch, Division of...

Communications and Intelligent Systems Division Overview

NASA Technical Reports Server (NTRS)

Emerson, Dawn

2017-01-01

Provides expertise, and plans, conducts and directs research and engineering development in the competency fields of advanced communications and intelligent systems technologies for applications in current and future aeronautics and space systems.Advances communication systems engineering, development and analysis needed for Glenn Research Center's leadership in communications and intelligent systems technology. Focus areas include advanced high frequency devices, components, and antennas; optical communications, health monitoring and instrumentation; digital signal processing for communications and navigation, and cognitive radios; network architectures, protocols, standards and network-based applications; intelligent controls, dynamics and diagnostics; and smart micro- and nano-sensors and harsh environment electronics. Research and discipline engineering allow for the creation of innovative concepts and designs for aerospace communication systems with reduced size and weight, increased functionality and intelligence. Performs proof-of-concept studies and analyses to assess the impact of the new technologies.

An Appreciation of the Life and Work of William C. Reynolds (1933-2004)

NASA Astrophysics Data System (ADS)

Moin, Parviz; Homsy, G. M.

2017-01-01

Bill Reynolds was a remarkably creative scientist who combined a natural curiosity with enormous energy to make significant contributions to fluid mechanics research. In this article, we combine our own recollections with those of many others to capture the aspects of Bill's personality and sense of humor that made him the irrepressible person that he was. We discuss his works on turbulent flow and touch on others that illustrate the wide range of his interests. We survey his involvement in education through classroom teaching and mentoring of research students, and his lifelong support of the Division of Fluid Dynamics of the American Physical Society. And we cover his many contributions during his long career at Stanford University, where he spent his entire working life, especially his seminal role with the Center for Turbulence Research.

Intelligent systems installed in building of research centre for research purposes

NASA Astrophysics Data System (ADS)

Matusov, Jozef; Mokry, Marian; Kolkova, Zuzana; Sedivy, Stefan

2016-06-01

The attractiveness of intelligent buildings is nowadays directly connected with higher level of comfort and also the economic mode of consumption energy for heating, cooling and the total consumption of electricity for electric devices. The technologies of intelligent buildings compared with conventional solutions allow dynamic optimization in real time and make it easy for operational message. The basic division of functionality in horizontal direction is possible divide in to two areas such as Economical sophisticated residential care about the comfort of people in the building and Security features. The paper deals with description of intelligent systems which has a building of Research Centre. The building has installed the latest technology for utilization of renewable energy and also latest systems of controlling and driving all devices which contribute for economy operation by achieving the highest thermal comfort and overall safety.

Boost-phase discrimination research

NASA Technical Reports Server (NTRS)

Langhoff, Stephen R.; Feiereisen, William J.

1993-01-01

The final report describes the combined work of the Computational Chemistry and Aerothermodynamics branches within the Thermosciences Division at NASA Ames Research Center directed at understanding the signatures of shock-heated air. Considerable progress was made in determining accurate transition probabilities for the important band systems of NO that account for much of the emission in the ultraviolet region. Research carried out under this project showed that in order to reproduce the observed radiation from the bow shock region of missiles in their boost phase it is necessary to include the Burnett terms in the constituent equation, account for the non-Boltzmann energy distribution, correctly model the NO formation and rotational excitation process, and use accurate transition probabilities for the NO band systems. This work resulted in significant improvements in the computer code NEQAIR that models both the radiation and fluid dynamics in the shock region.

Hurricane Research Division of AOML/NOAA

Science.gov Websites

Statement The mission of NOAA's Hurricane Research Division (HRD) is to advance the understanding and Learn More. What's New Links of Interest Hurricane Field Program Current Hurricane Data Hurricane FAQ

About the Mid-Continent Ecology Division (MED) of EPA's National Health and Environmental Effects Research Laboratory

EPA Pesticide Factsheets

The Mid-Continent Ecology Division (MED) conducts innovative research and predictive modeling to document and forecast the effects of pollutants on the integrity of watersheds and freshwater ecosystems.

Computational and Experimental Evaluation of a Complex Inlet Swirl Pattern Generation System (POSTPRINT)

DTIC Science & Technology

2016-08-01

Sanders, Chase A. Nessler, William W. Copenhaver, Michael G. List, and Timothy J. Janczewski Turbomachinery Branch Turbine Engine Division AUGUST...Branch Turbine Engine Division Turbine Engine Division Aerospace Systems Directorate //Signature// ROBERT D. HANCOCK Principal Scientist Turbine ...ORGANIZATION Turbomachinery Branch Turbine Engine Division Air Force Research Laboratory, Aerospace Systems Directorate Wright-Patterson Air Force

Tools for 3D scientific visualization in computational aerodynamics at NASA Ames Research Center

NASA Technical Reports Server (NTRS)

Bancroft, Gordon; Plessel, Todd; Merritt, Fergus; Watson, Val

1989-01-01

Hardware, software, and techniques used by the Fluid Dynamics Division (NASA) for performing visualization of computational aerodynamics, which can be applied to the visualization of flow fields from computer simulations of fluid dynamics about the Space Shuttle, are discussed. Three visualization techniques applied, post-processing, tracking, and steering, are described, as well as the post-processing software packages used, PLOT3D, SURF (Surface Modeller), GAS (Graphical Animation System), and FAST (Flow Analysis software Toolkit). Using post-processing methods a flow simulation was executed on a supercomputer and, after the simulation was complete, the results were processed for viewing. It is shown that the high-resolution, high-performance three-dimensional workstation combined with specially developed display and animation software provides a good tool for analyzing flow field solutions obtained from supercomputers.

59th Clinical Research Division Research Day Briefing

DTIC Science & Technology

2016-10-27

59th Medical Wing a ’r’. ’ ( ~ ~ ’ ""· ~... ’ .,,,. lS! lflof!’~l. 59th Clinical Research Division Research Day Briefing Colonel Linda Steel...oversight and guidance to researchers in the development, performance, and dissemination of clinical investigations. CRD directly supports wing...Clinical Investigation Support 2. Training 3. Support of RDT&E protocols 4. Research Subject Protection • Human Subjects: IRS - Institutional

7 CFR 3700.2 - Organization.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Organization. 3700.2 Section 3700.2 Agriculture Regulations of the Department of Agriculture (Continued) ECONOMIC RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE...; (c) Five Divisions; Commercial Agriculture Division, Food and Consumer Economics Division...

7 CFR 3700.2 - Organization.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false Organization. 3700.2 Section 3700.2 Agriculture Regulations of the Department of Agriculture (Continued) ECONOMIC RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE...; (c) Five Divisions; Commercial Agriculture Division, Food and Consumer Economics Division...

7 CFR 3700.2 - Organization.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Organization. 3700.2 Section 3700.2 Agriculture Regulations of the Department of Agriculture (Continued) ECONOMIC RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE...; (c) Five Divisions; Commercial Agriculture Division, Food and Consumer Economics Division...

7 CFR 3700.2 - Organization.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Organization. 3700.2 Section 3700.2 Agriculture Regulations of the Department of Agriculture (Continued) ECONOMIC RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE...; (c) Five Divisions; Commercial Agriculture Division, Food and Consumer Economics Division...

7 CFR 3700.2 - Organization.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Organization. 3700.2 Section 3700.2 Agriculture Regulations of the Department of Agriculture (Continued) ECONOMIC RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE...; (c) Five Divisions; Commercial Agriculture Division, Food and Consumer Economics Division...

Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover.

PubMed

Westera, Liset; van Hoeven, Vera; Drylewicz, Julia; Spierenburg, Gerrit; van Velzen, Jeroen F; de Boer, Rob J; Tesselaar, Kiki; Borghans, José A M

2015-04-01

In healthy humans, lymphocyte populations are maintained at a relatively constant size throughout life, reflecting a balance between lymphocyte production and loss. Given the profound immunological changes that occur during healthy aging, including a significant decline in T-cell production by the thymus, lymphocyte maintenance in the elderly is generally thought to require homeostatic alterations in lymphocyte dynamics. Surprisingly, using in vivo (2) H2 O labeling, we find similar dynamics of most lymphocyte subsets between young adult and elderly healthy individuals. As the contribution of thymic output to T-cell production is only minor from young adulthood onward, compensatory increases in peripheral T-cell division rates are not required to maintain the T-cell pool, despite a tenfold decline in thymic output. These fundamental insights will aid the interpretation of further research into aging and clinical conditions related to disturbed lymphocyte dynamics. © 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Lunar and planetary studies

NASA Technical Reports Server (NTRS)

Muhleman, Duane O.; Goldreich, P.; Ingersoll, A. P.; Westphal, J. A.

1988-01-01

This grant supports the core program in planetary astronomy at Caltech. The research includes observations in the IR, sub-mm, mm and cm wavelengths at national and Caltech observatories with a strong emphasis on integrating the observations with spacecraft data and with models of atmospheric structure, dynamics and chemistry. Muhleman's group made extensive observations of Saturn, Uranus and Neptune which are being interpreted in terms of deep atmospheric structures which are obvious in the 2 and 6 cm maps of Saturn and Uranus. The microwave measurements are one of the few sources of information below the 2 bar level. Goldreich is investigating the dynamics of narrow rings with postdoctoral fellow, Pierre-Yves Longaretti. Their work has focused on the role of collisional stresses on the precession of the rings, since the Voyager radio science results imply that the previous model based on the ring's self-gravity is not the entire story. In addition Borderies, Goldreich and Tremaine have completed an investigation of the dynamics of the Encke division in Saturn's A ring.

ROBUS-2: A Fault-Tolerant Broadcast Communication System

NASA Technical Reports Server (NTRS)

Torres-Pomales, Wilfredo; Malekpour, Mahyar R.; Miner, Paul S.

2005-01-01

The Reliable Optical Bus (ROBUS) is the core communication system of the Scalable Processor-Independent Design for Enhanced Reliability (SPIDER), a general-purpose fault-tolerant integrated modular architecture currently under development at NASA Langley Research Center. The ROBUS is a time-division multiple access (TDMA) broadcast communication system with medium access control by means of time-indexed communication schedule. ROBUS-2 is a developmental version of the ROBUS providing guaranteed fault-tolerant services to the attached processing elements (PEs), in the presence of a bounded number of faults. These services include message broadcast (Byzantine Agreement), dynamic communication schedule update, clock synchronization, and distributed diagnosis (group membership). The ROBUS also features fault-tolerant startup and restart capabilities. ROBUS-2 is tolerant to internal as well as PE faults, and incorporates a dynamic self-reconfiguration capability driven by the internal diagnostic system. This version of the ROBUS is intended for laboratory experimentation and demonstrations of the capability to reintegrate failed nodes, dynamically update the communication schedule, and tolerate and recover from correlated transient faults.

Think Tank: Identifying and Creating the Next Generation of Community-Based Cancer Prevention Studies | Division of Cancer Prevention

Cancer.gov

In late 2015, the NCI Division of Cancer Prevention convened cancer prevention research experts and stakeholders to discuss the current state of cancer prevention research, identify key prevention research priorities for the NCI, and identify studies that could be conducted within the NCI Community Oncology Research Program. Read the Cancer Prevention Research journal article

Bayesian Research at the NASA Ames Research Center,Computational Sciences Division

NASA Technical Reports Server (NTRS)

Morris, Robin D.

2003-01-01

NASA Ames Research Center is one of NASA s oldest centers, having started out as part of the National Advisory Committee on Aeronautics, (NACA). The site, about 40 miles south of San Francisco, still houses many wind tunnels and other aviation related departments. In recent years, with the growing realization that space exploration is heavily dependent on computing and data analysis, its focus has turned more towards Information Technology. The Computational Sciences Division has expanded rapidly as a result. In this article, I will give a brief overview of some of the past and present projects with a Bayesian content. Much more than is described here goes on with the Division. The web pages at http://ic.arc. nasa.gov give more information on these, and the other Division projects.

The Global Positioning System (GPS) and attitude determination: Applications and activities in the Flight Dynamics Division

NASA Technical Reports Server (NTRS)

Ketchum, Eleanor; Garrick, Joe

1995-01-01

The application of GPS to spacecraft attitude determination is a new and growing field. Although the theoretical literature is extensive, space flight testing is currently sparse and inadequate. As an operations organization, the Flight Dynamics Division (FDD) has the responsibility to investigate this new technology, and determine how best to implement the innovation to provide adequate support for future missions. This paper presents some of the current efforts within FDD with regard to GPS attitude determination. This effort specifically addresses institutional capabilities to accommodate a new type of sensor, critically evaluating the literature for recent advancements, and in examining some available -albeit crude- flight data.

Divisions of geologic time-major chronostratigraphic and geochronologic units

USGS Publications Warehouse

,

2010-01-01

Effective communication in the geosciences requires consistent uses of stratigraphic nomenclature, especially divisions of geologic time. A geologic time scale is composed of standard stratigraphic divisions based on rock sequences and is calibrated in years. Over the years, the development of new dating methods and the refinement of previous methods have stimulated revisions to geologic time scales. Advances in stratigraphy and geochronology require that any time scale be periodically updated. Therefore, Divisions of Geologic Time, which shows the major chronostratigraphic (position) and geochronologic (time) units, is intended to be a dynamic resource that will be modified to include accepted changes of unit names and boundary age estimates. This fact sheet is a modification of USGS Fact Sheet 2007-3015 by the U.S. Geological Survey Geologic Names Committee.

CoMIC, the hidden dynamics of mitochondrial inner compartments

PubMed Central

Cho, Bongki; Sun, Woong

2017-01-01

Mitochondria have evolutionarily, functionally and structurally distinct outer- (OMM) and inner-membranes (IMM). Thus, mitochondrial morphology is controlled by independent but coordinated activity of fission and fusion of the OMM and IMM. Constriction and division of the OMM are mediated by endocytosis-like machineries, which include dynamin-related protein 1 with additional cytosolic vesicle scissoring machineries such as actin filament and Dynamin 2. However, structural alteration of the IMM during mitochondrial division has been poorly understood. Recently, we found that the IMM and the inner compartments undergo transient and reversible constriction prior to the OMM division, which we termed CoMIC, Constriction of Mitochondrial Inner Compartment. In this short review, we further discuss the evolutionary perspective and the regulatory mechanism of CoMIC during mitochondrial division. PMID:28803609

CoMIC, the hidden dynamics of mitochondrial inner compartments.

PubMed

Cho, Bongki; Sun, Woong

2017-12-01

Mitochondria have evolutionarily, functionally and structurally distinct outer- (OMM) and inner-membranes (IMM). Thus, mitochondrial morphology is controlled by independent but coordinated activity of fission and fusion of the OMM and IMM. Constriction and division of the OMM are mediated by endocytosis-like machineries, which include dynamin-related protein 1 with additional cytosolic vesicle scissoring machineries such as actin filament and Dynamin 2. However, structural alteration of the IMM during mitochondrial division has been poorly understood. Recently, we found that the IMM and the inner compartments undergo transient and reversible constriction prior to the OMM division, which we termed CoMIC, Constriction of Mitochondrial Inner Compartment. In this short review, we further discuss the evolutionary perspective and the regulatory mechanism of CoMIC during mitochondrial division. [BMB Reports 2017; 50(12): 597-598].

R and E: Communications and Intelligent Systems Division (LC)

NASA Technical Reports Server (NTRS)

Emerson, Dawn C.; Miranda, Felix A.

2015-01-01

This presentation is intended for the Ohio Federal Research Network's Centers of Excellence. The presentation provides an overview of the Communications and Intelligent Systems Division including current research and engineering work as well as future technology needs.

Robert S. Kerr Environmental Research Center

EPA Science Inventory

The Kerr Center, situated on 16 acres three miles south of Ada, Oklahoma, houses the Ground Water and Ecosystems Restoration Division (GWERD) of the National Risk Management Research Laboratory (NRMRL). The division develops strategies and technologies to protect and restore grou...

Dynamics of gene expression with positive feedback to histone modifications at bivalent domains

NASA Astrophysics Data System (ADS)

Huang, Rongsheng; Lei, Jinzhi

2018-03-01

Experiments have shown that in embryonic stem cells, the promoters of many lineage-control genes contain “bivalent domains”, within which the nucleosomes possess both active (H3K4me3) and repressive (H3K27me3) marks. Such bivalent modifications play important roles in maintaining pluripotency in embryonic stem cells. Here, to investigate gene expression dynamics when there are regulations in bivalent histone modifications and random partition in cell divisions, we study how positive feedback to histone methylation/demethylation controls the transition dynamics of the histone modification patterns along with cell cycles. We constructed a computational model that includes dynamics of histone marks, three-stage chromatin state transitions, transcription and translation, feedbacks from protein product to enzymes to regulate the addition and removal of histone marks, and the inheritance of nucleosome state between cell cycles. The model reveals how dynamics of both nucleosome state transition and gene expression are dependent on the enzyme activities and feedback regulations. Results show that the combination of stochastic histone modification at each cell division and the deterministic feedback regulation work together to adjust the dynamics of chromatin state transition in stem cell regenerations.

Environmental Sciences Division: Summaries of research in FY 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This document describes the Fiscal Year 1996 activities and products of the Environmental Sciences Division, Office of Biological and Environmental Research, Office of Energy Research. The report is organized into four main sections. The introduction identifies the basic program structure, describes the programs of the Environmental Sciences Division, and provides the level of effort for each program area. The research areas and project descriptions section gives program contact information, and provides descriptions of individual research projects including: three-year funding history, research objective and approach used in each project, and results to date. Appendixes provide postal and e-mail addresses for principalmore » investigators and define acronyms used in the text. The indexes provide indexes of principal investigators, research institutions, and keywords for easy reference. Research projects are related to climatic change and remedial action.« less

PROFILE OF THE GULF ECOLOGY DIVISION, UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

EPA Science Inventory

A history of the man-made island on which the Gulf Ecology Division is located,from its origin in 1876 to the present day (2007). Contains a synopsis of current research and future plans of the division.

Lightning Talks 2015: Theoretical Division

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shlachter, Jack S.

2015-11-25

This document is a compilation of slides from a number of student presentations given to LANL Theoretical Division members. The subjects cover the range of activities of the Division, including plasma physics, environmental issues, materials research, bacterial resistance to antibiotics, and computational methods.

Human Systems Integration at NASA Ames Research Center

NASA Technical Reports Server (NTRS)

McCandless, Jeffrey

2017-01-01

The Human Systems Integration Division focuses on the design and operations of complex aerospace systems through analysis, experimentation and modeling. With over a dozen labs and over 120 people, the division conducts research to improve safety, efficiency and mission success. Areas of investigation include applied vision research which will be discussed during this seminar.

Purposing Division Strategy for Pharmaceutical Producer Dexa Medica in the Demanding Market

ERIC Educational Resources Information Center

Setiawati, Cut Irna; Wahyono, Agatha Christy

2017-01-01

This research aims to purpose the division strategy for a pharmaceutical producer in Kalimantan area, named Dexa Medica Samarinda. Currently, this firm is facing a competitive market condition and evolving a decline position in the market. This research uses qualitative research method by organising intensive interview to important informants so…

Division of Computer Research Summary of Awards. Fiscal Year 1984.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC. Directorate for Mathematical and Physical Sciences.

Provided in this report are summaries of grants awarded by the National Science Foundation Division of Computer Research in fiscal year 1984. Similar areas of research are grouped (for the purposes of this report only) into these major categories: (1) computational mathematics; (2) computer systems design; (3) intelligent systems; (4) software…

The C. elegans engrailed homolog ceh-16 regulates the self-renewal expansion division of stem cell-like seam cells.

PubMed

Huang, Xinxin; Tian, E; Xu, Yanhua; Zhang, Hong

2009-09-15

Stem cells undergo symmetric and asymmetric division to maintain the dynamic equilibrium of the stem cell pool and also to generate a variety of differentiated cells. The homeostatic mechanism controlling the choice between self-renewal and differentiation of stem cells is poorly understood. We show here that ceh-16, encoding the C. elegans ortholog of the transcription factor Engrailed, controls symmetric and asymmetric division of stem cell-like seam cells. Loss of function of ceh-16 causes certain seam cells, which normally undergo symmetric self-renewal expansion division with both daughters adopting the seam cell fate, to divide asymmetrically with only one daughter retaining the seam cell fate. The human engrailed homolog En2 functionally substitutes the role of ceh-16 in promoting self-renewal expansion division of seam cells. Loss of function of apr-1, encoding the C. elegans homolog of the Wnt signaling component APC, results in transformation of self-renewal maintenance seam cell division to self-renewal expansion division, leading to seam cell hyperplasia. The apr-1 mutation suppresses the seam cell division defect in ceh-16 mutants. Our study reveals that ceh-16 interacts with the Wnt signaling pathway to control the choice between self-renewal expansion and maintenance division and also demonstrates an evolutionarily conserved function of engrailed in promoting cell proliferation.

The Phragmoplast-Orienting Kinesin-12 Class Proteins Translate the Positional Information of the Preprophase Band to Establish the Cortical Division Zone in Arabidopsis thaliana[C][W

PubMed Central

Lipka, Elisabeth; Gadeyne, Astrid; Stöckle, Dorothee; Zimmermann, Steffi; De Jaeger, Geert; Ehrhardt, David W.; Kirik, Viktor; Van Damme, Daniel; Müller, Sabine

2014-01-01

The preprophase band (PPB) is a faithful but transient predictor of the division plane in somatic cell divisions. Throughout mitosis the PPBs positional information is preserved by factors that continuously mark the division plane at the cell cortex, the cortical division zone, by their distinct spatio-temporal localization patterns. However, the mechanism maintaining these identity factors at the plasma membrane after PPB disassembly remains obscure. The pair of kinesin-12 class proteins PHRAGMOPLAST ORIENTING KINESIN1 (POK1) and POK2 are key players in division plane maintenance. Here, we show that POK1 is continuously present at the cell cortex, providing a spatial reference for the site formerly occupied by the PPB. Fluorescence recovery after photobleaching analysis combined with microtubule destabilization revealed dynamic microtubule-dependent recruitment of POK1 to the PPB during prophase, while POK1 retention at the cortical division zone in the absence of cortical microtubules appeared static. POK function is strictly required to maintain the division plane identity factor TANGLED (TAN) after PPB disassembly, although POK1 and TAN recruitment to the PPB occur independently during prophase. Together, our data suggest that POKs represent fundamental early anchoring components of the cortical division zone, translating and preserving the positional information of the PPB by maintaining downstream identity markers. PMID:24972597

Character Education as a Bridge from Elementary to Middle School: A Case Study of Effective Practices and Processes

ERIC Educational Resources Information Center

Khoury, Ruba

2017-01-01

This qualitative single-case study illuminates the significance of effective character education implementation during elementary school years as students transition into middle school. The researcher conducted the study in an American school that consisted of two divisions: K-6 lower division and 7-12 upper division. The lower-school division was…

Earth Sciences Division Research Summaries 2002-2003

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bodvarsson, G.S.

2003-11-01

Research in earth and atmospheric sciences is becoming increasingly important in light of the energy, climate change, and environmental issues facing the United States and the world. The development of new energy resources other than hydrocarbons and the safe disposal of nuclear waste and greenhouse gases (such as carbon dioxide and methane) are critical to the future energy needs and environmental safety of this planet. In addition, the cleanup of many contaminated sites in the U.S., along with the preservation and management of our water supply, remain key challenges for us as well as future generations. Addressing these energy, climatemore » change, and environmental issues requires the timely integration of earth sciences' disciplines (such as geology, hydrology, oceanography, climatology, geophysics, geochemistry, geomechanics, ecology, and environmental sciences). This integration will involve focusing on fundamental crosscutting concerns that are common to many of these issues. A primary focus will be the characterization, imaging, and manipulation of fluids in the earth. Such capabilities are critical to many DOE applications, from environmental restoration to energy extraction and optimization. The Earth Sciences Division (ESD) of the Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab) is currently addressing many of the key technical issues described above. In this document, we present summaries of many of our current research projects. While it is not a complete accounting, it is representative of the nature and breadth of our research effort. We are proud of our scientific efforts, and we hope that you will find our research useful and exciting. Any comments on our research are appreciated and can be sent to me personally. This report is divided into five sections that correspond to the major research programs in the Earth Sciences Division: (1) Fundamental and Exploratory Research; (2) Nuclear Waste; (3) Energy Resources; (4) Environmental Remediation Technology; and (5) Climate Variability and Carbon Management. These programs draw from each of ESD's disciplinary departments: Microbial Ecology and Environmental Engineering, Geophysics and Geomechanics, Geochemistry, and Hydrogeology and Reservoir Dynamics. Short descriptions of these departments are provided as introductory material. A list of publications for the period from January 2002 to June 2003, along with a listing of our personnel, are appended to the end of this report.« less

Energy and Environment Division annual report, 1978

DOE Office of Scientific and Technical Information (OSTI.GOV)

Camp, J.A.

1978-01-01

Research activities of this Division are reported under nine separate programs, namely: Energy Analysis; Solar Energy; Energy-Efficient Buildings; Chemical Process Research and Development; Environmental Research; Atmospheric Aerosol Research; Oil Shale Research; Instrumentation Development; and Combustion Research. A separate abstract was prepared for each of the nine programs, each of which contained several individual research summaries, with responsible researchers listed. All of the abstracts will appear in Energy Research Abstracts (ERA), and five will appear in Energy Abstracts for Policy Analysis (EAPA).

Energy-efficient orthogonal frequency division multiplexing-based passive optical network based on adaptive sleep-mode control and dynamic bandwidth allocation

NASA Astrophysics Data System (ADS)

Zhang, Chongfu; Xiao, Nengwu; Chen, Chen; Yuan, Weicheng; Qiu, Kun

2016-02-01

We propose an energy-efficient orthogonal frequency division multiplexing-based passive optical network (OFDM-PON) using adaptive sleep-mode control and dynamic bandwidth allocation. In this scheme, a bidirectional-centralized algorithm named the receiver and transmitter accurate sleep control and dynamic bandwidth allocation (RTASC-DBA), which has an overall bandwidth scheduling policy, is employed to enhance the energy efficiency of the OFDM-PON. The RTASC-DBA algorithm is used in an optical line terminal (OLT) to control the sleep mode of an optical network unit (ONU) sleep and guarantee the quality of service of different services of the OFDM-PON. The obtained results show that, by using the proposed scheme, the average power consumption of the ONU is reduced by ˜40% when the normalized ONU load is less than 80%, compared with the average power consumption without using the proposed scheme.

Dynamics of phenotypic switching of bacterial cells with temporal fluctuations in pressure

NASA Astrophysics Data System (ADS)

Nepal, Sudip; Kumar, Pradeep

2018-05-01

Phenotypic switching is one of the mechanisms by which bacteria thrive in ever changing environmental conditions around them. Earlier studies have shown that the application of steady high hydrostatic pressure leads to stochastic switching of mesophilic bacteria from a cellular phenotype having a normal cell cycle to another phenotype lacking cell division. Here, we have studied the dynamics of this phenotypic switching with fluctuating periodic pressure using a set of experiments and a theoretical model. Our results suggest that the phenotypic switching rate from high-pressure phenotype to low-pressure phenotype in the reversible regime is larger as compared to the switching rate from low-pressure phenotype to high-pressure phenotype. Furthermore, we find that even though the cell division and elongation are presumably regulated by a large number of genes the underlying physics of the dynamics of stochastic switching at high pressure is captured reasonably well by a simple two-state model.

Overview of NASA Glenn Research Center's Communications and Intelligent Systems Division

NASA Technical Reports Server (NTRS)

Miranda, Felix A.

2016-01-01

The Communications and Intelligent Systems Division provides expertise, plans, conducts and directs research and engineering development in the competency fields of advanced communications and intelligent systems technologies for application in current and future aeronautics and space systems.

PUBLICATIONS (AIR POLLUTION TECHNOLOGY BRANCH, AIR POLLUTION PREVENTION AND CONTROL DIVISION, NRMRL)

EPA Science Inventory

The Air Pollution Technology Branch (APTB) of NRMRL's Air Pollution Prevention and Control Division produces and publishes highly specialized technical and scientific documents related to APTB's research. Areas of research covered include artificial intelligence, CFC destruction,...

Thursday's Agenda | Division of Cancer Prevention

Cancer.gov

TimeAgenda8:30 am - 8:50 amRegistration - Networking8:50 am - 8:55 amWelcome and Opening RemarksLeslie Ford, MDAssociate Director for Clinical ResearchDivision of Cancer Prevention, NCIEva Szabo, MD Chief, Lung and Upper Aerodigestive Cancer Research Group |

About the Atlantic Ecology Division (AED) of EPA's National Health and Environmental Effects Research Laboratory

EPA Pesticide Factsheets

The Atlantic Ecology Division (AED), conducts innovative research and predictive modeling to assess and forecast the risks of anthropogenic stressors to near coastal waters and their watersheds, to develop tools to support resilient watersheds.

DOE Office of Scientific and Technical Information (OSTI.GOV)

INSTRUMENTATION DIVISION STAFF

To develop state-of-the-art instrumentation required for experimental research programs at BNL, and to maintain the expertise and facilities in specialized high technology areas essential for this work. Development of facilities is motivated by present BNL research programs and anticipated future directions of BNL research. The Division's research efforts also have a significant impact on programs throughout the world that rely on state-of-the-art radiation detectors and readout electronics. Our staff scientists are encouraged to: Become involved in challenging problems in collaborations with other scientists; Offer unique expertise in solving problems; and Develop new devices and instruments when not commercially available. Scientistsmore » from other BNL Departments are encouraged to bring problems and ideas directly to the Division staff members with the appropriate expertise. Division staff is encouraged to become involved with research problems in other Departments to advance the application of new ideas in instrumentation. The Division Head integrates these efforts when they evolve into larger projects, within available staff and budget resources, and defines the priorities and direction with concurrence of appropriate Laboratory program leaders. The Division Head also ensures that these efforts are accompanied by strict adherence to all ES and H regulatory mandates and policies of the Laboratory. The responsibility for safety and environmental protection is integrated with supervision of particular facilities and conduct of operations.« less

A crucial step in cell division identified | Center for Cancer Research

Cancer.gov

When cell division doesn’t go according to plan, the resulting daughter cells can become unstable or even cancerous. A team of CCR investigators has now discovered a crucial step required for normal cell division to occur. Read more...

THE WESTERN ECOLOGY DIVISION STUDENT INTERN PROGRAM VIDEO

EPA Science Inventory

The Western Ecology Division of the National Health & Environmental Effects Research Laboratory has produced a 15 minute video documenting the internship program at the Division. The video highlights various CWEST student interns reporting on their experiences at an end-of-the-s...

An Evaluation of Operational Airspace Sectorization Integrated System (OASIS) Advisory Tool

NASA Technical Reports Server (NTRS)

Lee, Paul U.; Mogford, Richard H.; Bridges, Wayne; Buckley, Nathan; Evans, Mark; Gujral, Vimmy; Lee, Hwasoo; Peknik, Daniel; Preston, William

2013-01-01

In January 2013, a human-in-the-loop evaluation of the Operational Airspace Sectorization Integrated System (OASIS) was conducted in the Airspace Operations Laboratory of the Human Systems Integration Division (Code TH) in conjunction with the Aviation Systems Division (Code AF). The development of OASIS is a major activity of the Dynamic Airspace Configuration (DAC) research focus area within the Aeronautics Research Mission Directorate (ARMD) Airspace Systems Program. OASIS is an advisory tool to assist Federal Aviation Administration (FAA) En Route Area Supervisors in their planning of sector combinedecombine operations as well as opening closing of Data-side (D-side) control positions. These advisory solutions are tailored to the predicted traffic demand over the next few hours. During the experiment, eight retired FAA personnel served as participants for a part-task evaluation of OASIS functionality, covering the user interface as well as the underlying algorithm. Participants gave positive feedback on both the user interface and the algorithm solutions for airspace configuration, including an excellent average rating of 94 on the tool usability scales. They also suggested various enhancements to the OASIS tool, which will be incorporated into the next tool development cycle for the full-scale human-in-the-loop evaluation to be conducted later this year.

Fast aurora zone analysis

NASA Technical Reports Server (NTRS)

Booker, Mattie

1992-01-01

The Flight Dynamics Facility (FDF) of the Flight Dynamics Division (FDD), of the Goddard Space Flight Center provides acquisition data to tracking stations and orbit and attitude services to scientists and mission support personnel. The following paper explains how a method was determined that found spacecraft entry and exit times of the aurora zone.

Solid State Division progress report for period ending September 30, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, P.H.; Hinton, L.W.

1994-08-01

This report covers research progress in the Solid State Division from April 1, 1992, to September 30, 1993. During this period, the division conducted a broad, interdisciplinary materials research program with emphasis on theoretical solid state physics, neutron scattering, synthesis and characterization of materials, ion beam and laser processing, and the structure of solids and surfaces. This research effort was enhanced by new capabilities in atomic-scale materials characterization, new emphasis on the synthesis and processing of materials, and increased partnering with industry and universities. The theoretical effort included a broad range of analytical studies, as well as a new emphasismore » on numerical simulation stimulated by advances in high-performance computing and by strong interest in related division experimental programs. Superconductivity research continued to advance on a broad front from fundamental mechanisms of high-temperature superconductivity to the development of new materials and processing techniques. The Neutron Scattering Program was characterized by a strong scientific user program and growing diversity represented by new initiatives in complex fluids and residual stress. The national emphasis on materials synthesis and processing was mirrored in division research programs in thin-film processing, surface modification, and crystal growth. Research on advanced processing techniques such as laser ablation, ion implantation, and plasma processing was complemented by strong programs in the characterization of materials and surfaces including ultrahigh resolution scanning transmission electron microscopy, atomic-resolution chemical analysis, synchrotron x-ray research, and scanning tunneling microscopy.« less

75 FR 70002 - Senior Executive Service Performance Review Board; Membership

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-16

... CONTACT: Karen D. Higginbotham, Director, Executive Resources Division, 3606A, Office of Human Resources... Human Resources, Office of Administration and Resources Management; William H. Benson, Director, Gulf Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and...

GENDER-SPECIFIC DIFFERENCES IN THE RESPONSE OF MATURING GAMETES TO TOXIC INSULT

EPA Science Inventory

GENDER-SPECIFIC DIFFERENCES IN THE RESPONSE OF MATURING GAMETES TO TOXIC INSULT

Sally D. Perreault, U. S. Environmental Toxicology Division, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Research Triangle Park, NC 27711

Progress at LAMPF: Clinton P. Anderson Meson Physics Facility. Progress report, January-June 1981

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allred, J.C.

1981-09-01

Progress at LAMPF is the semiannual progress report of the MP Division of the Los Alamos National Laboratory. The report includes brief reports on research done at LAMPF by researchers from other institutions and Los Alamos divisions.

Educational research at Johns Hopkins University School of Medicine: a grassroots development.

PubMed

Thomas, Patricia A; Wright, Scott M; Kern, David E

2004-10-01

The Divisions of General Internal Medicine at Johns Hopkins University School of Medicine have been a rich source of educational research. To better understand the facilitators and barriers to educational research within the divisions, the authors reviewed published educational research from the divisions published between 1995-2004 and examined the history, leadership decisions, and sentinel events that have allowed educational scholarship within the divisions to grow. The authors' analysis suggests a grassroots model of programmatic growth that includes a growing cadre of clinician-educator scholars, effective mentorship, a faculty development program, access to learners, access to research expertise, protected time for scholarship, some funding, and an institutional culture that stimulates scholarship. A medical education fellowship was integral to the model; fellows were first authors for 47% of reviewed manuscripts. Extramural funding has helped build an infrastructure that supports educational scholarship; however, only 12% of the publications have had extramural funding. Protected time for faculty is the characteristic of this model most at risk. While there has been a move toward more institutional support of educational research, it is clear that further growth in the educational research program will require noninstitutional resources.

Summaries of FY 1979 research in the chemical sciences

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1980-05-01

The purpose of this report is to help those interested in research supported by the Department of Energy's Division of Chemical Sciences, which is one of six Divisions of the Office of Basic Energy Sciences in the Office of Energy Research. Chemists, physicists, chemical engineers and others who are considering the possibility of proposing research for support by this Division wll find the booklet useful for gauging the scope of the program in basic research, and the relationship of their interests to the overall program. These smmaries are intended to provide a rapid means for becoming acquainted with the Chemicalmore » Sciences program for members of the scientific and technological public, and interested persons in the Legislative and Executive Branches of the Government, in order to indicate the areas of research supported by the Division and energy technologies which may be advanced by use of basic knowledge discovered in this program. Scientific excellence is a major criterion applied in the selection of research supported by Chemical Sciences. Another important consideration is the identifying of chemical, physical and chemical engineering subdisciplines which are advancing in ways which produce new information related to energy, needed data, or new ideas.« less

Physics division annual report 2000.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thayer, K., ed.

2001-10-04

This report summarizes the research performed in 2000 in the Physics Division of Argonne National Laboratory. The Division's programs include operation of ATLAS as a national user facility, nuclear structure and reaction research, nuclear theory and medium energy physics research, and accelerator research and development. As the Nuclear Science Advisory Committee and the nuclear science community create a new long range plan for the field in 2001, it is clear that the research of the Division is closely aligned with and continues to help define the national goals of our field. The NSAC 2001 Long Range Plan recommends as themore » highest priority for major new construction the Rare Isotope Accelerator (RIA), a bold step forward for nuclear structure and nuclear astrophysics. The accelerator R&D in the Physics Division has made major contributions to almost all aspects of the RIA design concept and the community was convinced that this project is ready to move forward. 2000 saw the end of the first Gammasphere epoch at ATLAS, One hundred Gammasphere experiments were completed between January 1998 and March 2000, 60% of which used the Fragment Mass Analyzer to provide mass identification in the reaction. The experimental program at ATLAS then shifted to other important research avenues including proton radioactivity, mass measurements with the Canadian Penning Trap and measurements of high energy gamma-rays in nuclear reactions with the MSU/ORNL/Texas A&M BaF{sub 2} array. ATLAS provided 5460 beam-research hours for user experiments and maintained an operational reliability of 95%. Radioactive beams accounted for 7% of the beam time. ATLAS also provided a crucial test of a key RIA concept, the ability to accelerate multiple charge states in a superconducting heavy-ion linac. This new capability was immediately used to increase the performance for a scheduled experiment. The medium energy program continued to make strides in examining how the quark-gluon structure of matter impacts the structure of nuclei and extended the exquisite sensitivity of the Atom-Trap-Trace-Analysis technique to new species and applications. All of this progress was built on advances in nuclear theory, which the Division pursues at the quark, hadron, and nuclear collective degrees of freedom levels. These are just a few of the highlights in the Division's research program. The results reflect the talents and dedication of the Physics Division staff and the visitors, guests and students who bring so much to the research.« less

3D Grain Reconstruction from Boxscan Data

DTIC Science & Technology

2010-01-01

H.F. Poulsen∗ and E. M. Lauridsen∗ ∗ Center for Fundamental Research: Metal Structures in Four Dimensions, Materials Research Division, Risø- DTU , DK...Center for Fundamental Research,Metal Structures in FOur Dimensions, Materials Research Division,Riso- DTU , DK-4000,Roskilde, Denmark, 8. PERFORMING...provision of beam time by the ESRF, Grenoble, France, is greatly acknowledged. Furthermore, the staff at Risø- DTU thanks R. Gardner for valuable

Teamwork in Task Analysis. Training Manual V

DTIC Science & Technology

1975-11-01

Research Programs Psychological Sciences Division Office of Naval Research Contract No. N00014-74-A-0436-0001 NR 151-370 Approved for public...Corps (Code RD) And Monitored By Personnel and Training Research Programs Psychological Sciences Division Office of Naval Research Contract No...survival in the hidden warfare of the destructive psychological win-lose game. Win-lose behavior stems from individual attitudes and manage- ment climate

ARC-2009-ACD09-0261-013

NASA Image and Video Library

2009-12-10

Korean High Level Delegation Visit Ames Certer Director and various Senior staff: Dan Andrews give presentation about LCROSS/LRO to Seorium Lee, Senior Researcher, International Relations Korea Aerospace Research Institute, Soon-Duk Bae, Deputy Director, Big Science Policy Division, Ministry of Educaiton, Science Technology, Young-Mok Hyun, Deputy Director, Space Development Division, Ministry of Educaiton, Science Technology, Seorium Lee, Senior Researcher, International Relations Korea Aerospace Research Institute.

Staff survey of organizational structure and process for a Public Health Department.

PubMed

Dwyer, J J

1995-01-01

A survey of 227 North York Public Health Department (NYPHD) staff provided their perspective on the organizational structure. They perceived that (a) the departmental and divisional organizational structures are effective for program delivery, (b) the Central Resources structure and divisional and departmental reporting structures are moderately effective for program delivery, (c) the decentralized office structure is an advantage for service delivery but less so for administration and intra-division and inter-division communication, (d) the mandatory program structure involves low to moderate interdisciplinary teamwork and moderately impacts service delivery, (e) intra-division and management-staff communication are fair but inter-division and office communication are between poor and fair, (f) education, research, and service are moderately integrated, and (g) the divisional and departmental work atmospheres are a little positive. Management perceived greater participation in program planning, more frequent communication with other divisions, a number of education and research opportunities from various divisions/units, and more management recognition than front line staff did.

[50 years anniversary of Research Institute for Occupational Medicine and Human Ecology with Siberian Division of RAMSc].

PubMed

Rukavishnikov, V S; Shaiakhmetov, S F; Gus'kova, T M

2010-01-01

The article covers main steps of establishment and development of Research Institute for Occupational medicine and Human ecology with Siberian Division of RAMSc over 50 years of activities, major results of research, contribution of the Institute personnel into development of hygienic science and practical medicine in Siberia.

The John Milner Nutrition and Cancer Prevention Research Practicum | Division of Cancer Prevention

Cancer.gov

The Nutritional Science Research Group in the Division of Cancer Prevention at the National Cancer Institute, National Institutes of Health and the Department of Nutrition at the Clinical Center, National Institutes of Health, and the US Department of Agriculture's Beltsville Human Nutrition Research Center are offering a one week educational opportunity in "Nutrition and

Nutrition and Cancer Prevention Research Practicum | Division of Cancer Prevention

Cancer.gov

The Nutritional Science Research Group in the Division of Cancer Prevention at the National Cancer Institute, National Institutes of Health and the Department of Nutrition at the Clinical Center, National Institutes of Health are offering a one week educational opportunity in "Nutrition and Cancer Prevention Research" for individuals with a sustained commitment to nutrition

Unified quantitative characterization of epithelial tissue development

PubMed Central

Guirao, Boris; Rigaud, Stéphane U; Bosveld, Floris; Bailles, Anaïs; López-Gay, Jesús; Ishihara, Shuji; Sugimura, Kaoru

2015-01-01

Understanding the mechanisms regulating development requires a quantitative characterization of cell divisions, rearrangements, cell size and shape changes, and apoptoses. We developed a multiscale formalism that relates the characterizations of each cell process to tissue growth and morphogenesis. Having validated the formalism on computer simulations, we quantified separately all morphogenetic events in the Drosophila dorsal thorax and wing pupal epithelia to obtain comprehensive statistical maps linking cell and tissue scale dynamics. While globally cell shape changes, rearrangements and divisions all significantly participate in tissue morphogenesis, locally, their relative participations display major variations in space and time. By blocking division we analyzed the impact of division on rearrangements, cell shape changes and tissue morphogenesis. Finally, by combining the formalism with mechanical stress measurement, we evidenced unexpected interplays between patterns of tissue elongation, cell division and stress. Our formalism provides a novel and rigorous approach to uncover mechanisms governing tissue development. DOI: http://dx.doi.org/10.7554/eLife.08519.001 PMID:26653285

Quasi-Square Hole with Optimum Shape in an Infinite Plate Subjected to In-Plane Loading. Optimization of Inner and Outer Boundaries of Beams and Plates with Holes,

DTIC Science & Technology

1982-04-01

Division 045 Administracion Naval Ship Resarc; and Development 14114 (Technical Library) Structures Research Division Center Langley Research Center...Virginia 23607 university of California. San Diego Dr. J. L. Swedlow Department of Applied Mechanics Carnegie-Mellon University La Jolla, California...Batdorf Keman AviDyne Suite 220 University of California Division of Kaman La Jolla, California 92037 School of Engineering Sciences Corporation and

Structure formation in binary mixtures of lipids and detergents: self-assembly and vesicle division.

PubMed

Noguchi, Hiroshi

2013-01-14

Self-assembly dynamics in binary surfactant mixtures and structure changes of lipid vesicles induced by detergent solution are studied using coarse-grained molecular simulations. Disk-shaped micelles, the bicelles, are stabilized by detergents surrounding the rim of a bilayer disk of lipids. The self-assembled bicelles are considerably smaller than bicelles formed from vesicle rupture, and their size is determined by the concentrations of lipids and detergents and the interactions between the two species. The detergent-adsorption induces spontaneous curvature of the vesicle bilayer and results in vesicle division into two vesicles or vesicle rupture into worm-like micelles. The division occurs mainly via the inverse pathway of the modified stalk model. For large spontaneous curvature of the monolayers of the detergents, a pore is often opened, thereby leading to vesicle division or worm-like micelle formation.

A COMPARATIVE ANALYSIS OF THE RESEARCH UTILIZATION PROCESS.

ERIC Educational Resources Information Center

LIPPITT, RONALD; AND OTHERS

A SUGGESTED MODEL FOR ADEQUATE DISSEMINATION OF RESEARCH FINDINGS CONSIDERS FOUR PRIMARY BARRIERS TO EFFECTIVE COMMUNICATION--(1) DIVISION OF PERSONNEL LABOR INTO TASK ROLES, (2) INSTITUTIONAL DISTINCTIONS, (3) DEVELOPMENT OF PROFESSIONAL REFERENCE GROUPS, AND (4) GEOGRAPHICAL DIVISIONS. SUGGESTED SOLUTIONS INCLUDE LINKING SYSTEMS AND ROLES,…

1997 JOURNAL ARTICLES FROM LRPCD (TREATMENT AND DESTRUCTION BRANCH, LAND REMEDIATION AND POLLUTION CONTROL DIVISION, NRMRL)

EPA Science Inventory

The Treatment and Destruction Branch (TDB) of NRMRL's Land Remediation and Pollution Control Division (LRPCD) produces and publishes highly technical and scientific documents relating to TDB's research. TDB conducts bioremediation and physical/chemical treatment research. The res...

1996 JOURNAL ARTICLES FROM LRPCD (TREATMENT AND DESTRUCTION BRANCH, LAND REMEDIATION AND POLLUTION CONTROL DIVISION, NRMRL)

EPA Science Inventory

The Treatment and Destruction Branch (TDB) of NRMRL's Land Remediation and Pollution Control Division (LRPCD) produces and publishes highly technical and scientific articles relating to TDB's research. TDB conducts bioremediation and physical/chemical treatment research. The rese...

1998 JOURNAL ARTICLES FROM LRPCD (TREATMENT AND DESTRUCTION BRANCH, LAND REMEDIATION AND POLLUTION CONTROL DIVISION, NRMRL)

EPA Science Inventory

The Treatment and Destruction Branch (TDB) of NRMRL's Land Remediation and Pollution Control Division (LRPCD) produces and publishes highly technical and scientific documents relating to TDB's research. TDB conducts bioremediation and physical/chemical treatment research. The res...

1999 JOURNAL ARTICLES FROM LRPCD (TREATMENT AND DESTRUCTION BRANCH, LAND REMEDIATION AND POLLUTION CONTROL DIVISION, NRMRL)

EPA Science Inventory

The Treatment and Destruction Branch (TDB) of NRMRL's Land Remediation and Pollution Control Division (LRPCD) produces and publishes highly technical and scientific documents relating to TDB's research. TDB conducts bioremediation and physical/chemical treatment research. The res...

NEAR ROADWAY RESEARCH IN THE ATMOSPHERIC MODELING DIVISION

EPA Science Inventory

This is a presentation to the CRC Mobile Source Air Toxics Workshop in Phoenix, AZ, on 23 October 2006. The presentation provides an overview of air quality modeling research in the USEPA/ORD/NERL's Atmospheric Modeling Division, with an emphasis on near-road pollutant character...

76 FR 29770 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-23

... K. Saha, PhD, Scientific Review Officer, Program Coordination and Referral Branch, Division of..., PhD, Scientific Review Officer, Scientific Review and Logistic Branch, Division of Extramural....395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93...

75 FR 60465 - Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-30

.... 93.14, Intramural Research Training Award; 93.22, Clinical Research Loan Repayment Program for... Program; 93.187, Undergraduate Scholarship Program for Individuals from Disadvantaged Backgrounds... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Division of Program...

Methods for geochemical analysis

USGS Publications Warehouse

Baedecker, Philip A.

1987-01-01

The laboratories for analytical chemistry within the Geologic Division of the U.S. Geological Survey are administered by the Office of Mineral Resources. The laboratory analysts provide analytical support to those programs of the Geologic Division that require chemical information and conduct basic research in analytical and geochemical areas vital to the furtherance of Division program goals. Laboratories for research and geochemical analysis are maintained at the three major centers in Reston, Virginia, Denver, Colorado, and Menlo Park, California. The Division has an expertise in a broad spectrum of analytical techniques, and the analytical research is designed to advance the state of the art of existing techniques and to develop new methods of analysis in response to special problems in geochemical analysis. The geochemical research and analytical results are applied to the solution of fundamental geochemical problems relating to the origin of mineral deposits and fossil fuels, as well as to studies relating to the distribution of elements in varied geologic systems, the mechanisms by which they are transported, and their impact on the environment.

Kenneth J. Szalai

NASA Technical Reports Server (NTRS)

1997-01-01

Kenneth J. Szalai was Director of the NASA Hugh L. Dryden Flight Research Center, Edwards, Calif., from January 1994 through July 1998. He retired from NASA at the end of July to join IBP Aerospace Group, Inc., as the company's new president and chief operating officer. As NASA's primary installation for flight research for more than half a century, Dryden is chartered to conceive and conduct experimental flight research for integrated flight and propulsion controls; advanced optical sensors and controls; viscous drag reduction; advanced configurations; high-altitude, long-endurance aircraft; remotely piloted vehicle technology; hypersonic vehicle experiments; high-speed research for civil transportation; atmospheric tests of advanced rocket and airbreathing propulsion concepts; instrumentation systems; and flight loads predictions. In carrying out this mission, Dryden operates some of the most advanced research aircraft in the nation. When Dryden was administratively a part of the NASA Ames Research Center, Moffett Field, Calif., Szalai was director and also held the position of Ames Deputy Director for Dryden from December 1990 until assuming his current position From 1982 until December 1990, Szalai directed the Dryden Research Engineering Division. He served as Associate Director of the Ames Research Center in 1989. Prior to 1982 he was chief of the Research Engineering Division's Dynamics and Control Branch, and chief of the Flight Control Section. Szalai began his NASA career at Dryden in 1964 following graduation from the University of Wisconsin, where he attended both the Milwaukee and Madison campuses. His bachelor of science degree is in electrical engineering. He also received a master of science degree in mechanical engineering from the University of Southern California in 1970. Szalai was principal investigator on the F-8 Digital Fly-By-Wire program, which successfully flew the first aircraft equipped with a digital electronic flight control system without any mechanical reversion capability. Szalai also held research and systems engineering positions on several research aircraft programs investigating flying qualities, integrated flight controls, and fault tolerant-flight critical systems. He was also flight test engineer and principal investigator on the NASA Airborne Simulator before assuming management positions within the Research Engineering Division. Szalai has worked in various technical and management positions on such programs as the F-111 IPCS, AFTI/F-16, HiMAT, F-15 DEEC, F-15 HIDEC, X-29, X-31, F-16XL Laminar Flow, Space Shuttle Orbiter, Pathfinder Solar Powered Aircraft, SR-71 Sonic Boom, F-15 and MD-11 Propulsion Controlled Aircraft, X-33, and X-38. Szalai has authored over 25 papers and reports and has been a lecturer for the NATO Advisory Group for Aeronautical Research and Development (AGARD). He has served on various technical committees and subcommittees for the American Institute of Aeronautics and Astronautics (AIAA) and Society of Automotive Engineers (SAE). Szalai, a Fellow of the AIAA, also served on the National Academy of Science's 'Aeronautics-2000' study. Among the awards Szalai has received are NASA's Exceptional Service Medal, the NASA Outstanding Leadership Medal, and the Presidential Meritorious and Distinguished Rank awards. Szalai was born June 1, 1942, in Milwaukee, Wisc., where he graduated from West Division High School.

The histone codes for meiosis.

PubMed

Wang, Lina; Xu, Zhiliang; Khawar, Muhammad Babar; Liu, Chao; Li, Wei

2017-09-01

Meiosis is a specialized process that produces haploid gametes from diploid cells by a single round of DNA replication followed by two successive cell divisions. It contains many special events, such as programmed DNA double-strand break (DSB) formation, homologous recombination, crossover formation and resolution. These events are associated with dynamically regulated chromosomal structures, the dynamic transcriptional regulation and chromatin remodeling are mainly modulated by histone modifications, termed 'histone codes'. The purpose of this review is to summarize the histone codes that are required for meiosis during spermatogenesis and oogenesis, involving meiosis resumption, meiotic asymmetric division and other cellular processes. We not only systematically review the functional roles of histone codes in meiosis but also discuss future trends and perspectives in this field. © 2017 Society for Reproduction and Fertility.

Single-shot thermal ghost imaging using wavelength-division multiplexing

NASA Astrophysics Data System (ADS)

Deng, Chao; Suo, Jinli; Wang, Yuwang; Zhang, Zhili; Dai, Qionghai

2018-01-01

Ghost imaging (GI) is an emerging technique that reconstructs the target scene from its correlated measurements with a sequence of patterns. Restricted by the multi-shot principle, GI usually requires long acquisition time and is limited in observation of dynamic scenes. To handle this problem, this paper proposes a single-shot thermal ghost imaging scheme via a wavelength-division multiplexing technique. Specifically, we generate thousands of correlated patterns simultaneously by modulating a broadband light source with a wavelength dependent diffuser. These patterns carry the scene's spatial information and then the correlated photons are coupled into a spectrometer for the final reconstruction. This technique increases the speed of ghost imaging and promotes the applications in dynamic ghost imaging with high scalability and compatibility.

Teaching Cell Division: Basics and Recommendations.

ERIC Educational Resources Information Center

Smith, Mike U.; Kindfield, Ann C. H.

1999-01-01

Presents a concise overview of cell division that includes only the essential concepts necessary for understanding genetics and evolution. Makes recommendations based on published research and teaching experiences that can be used to judge the merits of potential activities and materials for teaching cell division. Makes suggestions regarding the…

Dynamic distribution of the SecA and SecY translocase subunits and septal localization of the HtrA surface chaperone/protease during Streptococcus pneumoniae D39 cell division.

PubMed

Tsui, Ho-Ching Tiffany; Keen, Susan K; Sham, Lok-To; Wayne, Kyle J; Winkler, Malcolm E

2011-01-01

The Sec translocase pathway is the major route for protein transport across and into the cytoplasmic membrane of bacteria. Previous studies reported that the SecA translocase ATP-binding subunit and the cell surface HtrA protease/chaperone formed a single microdomain, termed "ExPortal," in some species of ellipsoidal (ovococcus) Gram-positive bacteria, including Streptococcus pyogenes. To investigate the generality of microdomain formation, we determined the distribution of SecA and SecY by immunofluorescent microscopy in Streptococcus pneumoniae (pneumococcus), which is an ovococcus species evolutionarily distant from S. pyogenes. In the majority (≥ 75%) of exponentially growing cells, S. pneumoniae SecA (SecA (Spn)) and SecY (Spn) located dynamically in cells at different stages of division. In early divisional cells, both Sec subunits concentrated at equators, which are future sites of constriction. Further along in division, SecA(Spn) and SecY(Spn) remained localized at mid-cell septa. In late divisional cells, both Sec subunits were hemispherically distributed in the regions between septa and the future equators of dividing cells. In contrast, the HtrA (Spn) homologue localized to the equators and septa of most (> 90%) dividing cells, whereas the SrtA(Spn) sortase located over the surface of cells in no discernable pattern. This dynamic pattern of Sec distribution was not perturbed by the absence of flotillin family proteins, but was largely absent in most cells in early stationary phase and in cls mutants lacking cardiolipin synthase. These results do not support the existence of an ExPortal microdomain in S. pneumoniae. Instead, the localization of the pneumococcal Sec translocase depends on the stage of cell division and anionic phospholipid content. Two patterns of Sec translocase distribution, an ExPortal microdomain in certain ovococcus-shaped species like Streptococcus pyogenes and a spiral pattern in rod-shaped species like Bacillus subtilis, have been reported for Gram-positive bacteria. This study provides evidence for a third pattern of Sec localization in the ovococcus human pathogen Streptococcus pneumoniae. The SecA motor and SecY channel subunits of the Sec translocase localize dynamically to different places in the mid-cell region during the division cycle of exponentially growing, but not stationary-phase, S. pneumoniae. Unexpectedly, the S. pneumoniae HtrA (HtrA(Spn)) protease/chaperone principally localizes to cell equators and division septa. The coincident localization of SecA(Spn), SecY (Spn), and HtrA (Spn) to regions of peptidoglycan (PG) biosynthesis in unstressed, growing cells suggests that the pneumococcal Sec translocase directs assembly of the PG biosynthesis apparatus to regions where it is needed during division and that HtrA(Spn) may play a general role in quality control of proteins exported by the Sec translocase.

Gender Writ Small: Gender Enactments and Gendered Narratives about Lab Organization and Knowledge Transmission in a Biomedical Engineering Research Setting

NASA Astrophysics Data System (ADS)

Malone, Kareen Ror; Nersessian, Nancy J.; Newstetter, Wendy

This article presents qualitative data and offers some innovative theoretical approaches to frame the analysis of gender in science, technology, engineering, and mathematics (STEM) settings. It begins with a theoretical discussion of a discursive approach to gender that captures how gender is lived "on the ground." The authors argue for a less individualistic approach to gender. Data for this research project was gathered from intensive interviews with lab members and ethnographic observations in a biomedical engineering lab. Data analysis relied on a mixed methodology involving qualitative approaches and dialogues with findings from other research traditions. Three themes are highlighted: lab dynamics in relation to issues of critical mass, the division of labor, and knowledge transmission. The data illustrate how gender is created in interactions and is inflected through forms of social organization.

Improving the efficiency of the Finite Temperature Density Matrix Renormalization Group method

NASA Astrophysics Data System (ADS)

Nocera, Alberto; Alvarez, Gonzalo

I review the basics of the finite temperature DMRG method, and then show how its efficiency can be improved by working on reduced Hilbert spaces and by using canonical approaches. My talk explains the applicability of the ancilla DMRG method beyond spins systems to t-J and Hubbard models, and addresses the computation of static and dynamical observables at finite temperature. Finally, I discuss the features of and roadmap for our DMRG + + codebase. Work done at CNMS, sponsored by the SUF Division, BES, U.S. DOE under contract with UT-Battelle. Support by the early career research program, DSUF, BES, DOE.

Dynamic FtsA and FtsZ localization and outer membrane alterations during polar growth and cell division in Agrobacterium tumefaciens

PubMed Central

Zupan, John R.; Cameron, Todd A.; Anderson-Furgeson, James; Zambryski, Patricia C.

2013-01-01

Growth and cell division in rod-shaped bacteria have been primarily studied in species that grow predominantly by peptidoglycan (PG) synthesis along the length of the cell. Rhizobiales species, however, predominantly grow by PG synthesis at a single pole. Here we characterize the dynamic localization of several Agrobacterium tumefaciens components during the cell cycle. First, the lipophilic dye FM 4-64 predominantly stains the outer membranes of old poles versus growing poles. In cells about to divide, however, both poles are equally labeled with FM 4-64, but the constriction site is not. Second, the cell-division protein FtsA alternates from unipolar foci in the shortest cells to unipolar and midcell localization in cells of intermediate length, to strictly midcell localization in the longest cells undergoing septation. Third, the cell division protein FtsZ localizes in a cell-cycle pattern similar to, but more complex than, FtsA. Finally, because PG synthesis is spatially and temporally regulated during the cell cycle, we treated cells with sublethal concentrations of carbenicillin (Cb) to assess the role of penicillin-binding proteins in growth and cell division. Cb-treated cells formed midcell circumferential bulges, suggesting that interrupted PG synthesis destabilizes the septum. Midcell bulges contained bands or foci of FtsA-GFP and FtsZ-GFP and no FM 4-64 label, as in untreated cells. There were no abnormal morphologies at the growth poles in Cb-treated cells, suggesting unipolar growth uses Cb-insensitive PG synthesis enzymes. PMID:23674672

Major Programs | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention supports major scientific collaborations, research networks, investigator-initiated grants, postdoctoral training, and specialized resources across the United States. |

Metals and Ceramics Division progress report for period ending June 30, 1984

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brogden, I.

1984-09-01

This progress report covers the research and development activities of the Metals and Ceramics Division from January 1, 1983, through June 30, 1984. The format of the report follows the organizational structure of the division. Short summaries of technical work in progress in the various experimental groups are presented in six parts. Chapter 1 deals with the research and development activities of the Engineering Materials Section, Chapter 2 with the Processing Science and Technology Section, Chapter 3 with the Materials Science Section, Chapter 4 with Project Activities, Chapter 5 with Specialized Research Facilities and Equipment, and Chapter 6 with Miscellaneousmore » Activities.« less

A Description and Comparison of the Perceptions of NCAA Division II and Division III College Presidents Regarding the Impacts of Intercollegiate Athletics at Their Institutions

ERIC Educational Resources Information Center

Huffman, Aaron C.

2013-01-01

The purpose of this study was to describe and compare the perceptions of NCAA Division II and NCAA Division III college and university presidents regarding the impacts of intercollegiate athletics at their institutions. The data were collected with an anonymous online survey instrument developed by the researcher and sent via email using…

American Chemical Society division of fuel chemistry Henry H. Storch award.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chemistry

American Chemical Society Division of Fuel Chemistry Henry H. Storch Award ... The purpose of the Henry H. Storch Award is to recognize distinguished contributions worldwide to fundamental or engineering research on the chemistry and utilization of all hydrocarbon fuels, with the exception of petroleum. ... The award was established in 1964 by the American Chemical Society Division of Fuel Chemistry and administered by the Division until 1985.

Cognitive and Neural Sciences Division 1991 Programs

DTIC Science & Technology

1991-08-01

FUNDING NUMBERS Cognitive and Neural Sciences Division 1991 Programs PE 61153N 6. AUTHOR(S) Edited by Willard S. Vaughan 7. PERFORMING ORGANIZATION...NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Office of Naval Research 0CNR !1491-19 Cognitive and Neural Sciences Division Code 1142...NOTES iN This is a compilation of abstracts representing R&D sponsored by the ONR Cognitive and Neural Sciences Division. 12a. DISTRIBUTION

Flux line relaxation kinetics following current quenches in disordered type-II superconductors

NASA Astrophysics Data System (ADS)

Chaturvedi, Harshwardhan; Assi, Hiba; Dobramysl, Ulrich; Pleimling, Michel; Täuber, Uwe

We describe the disordered vortex system in type-II superconductors with an elastic line model, whose dynamics we investigate numerically by means of Langevin Molecular Dynamics. A system of driven interacting flux lines in a sample with randomly distributed point pinning centers is subjected to drive quench from a moving non-equilibrium steady state into one of three regimes viz. moving (steady state), pinned (glassy) or depinning (critical). The first yields fast exponential relaxation to the new non-equilibrium stationary state while the second displays algebraically slow relaxation and aging scaling with non-universal exponents. Our most recent work consists of aging and finite temperature scaling studies for drive quenches into the critical depinning regime. This research is supported by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering under Award DE-FG02-09ER46613.

Interactive information processing for NASA's mesoscale analysis and space sensor program

NASA Technical Reports Server (NTRS)

Parker, K. G.; Maclean, L.; Reavis, N.; Wilson, G.; Hickey, J. S.; Dickerson, M.; Karitani, S.; Keller, D.

1985-01-01

The Atmospheric Sciences Division (ASD) of the Systems Dynamics Laboratory at NASA's Marshall Space Flight Center (MSFC) is currently involved in interactive information processing for the Mesoscale Analysis and Space Sensor (MASS) program. Specifically, the ASD is engaged in the development and implementation of new space-borne remote sensing technology to observe and measure mesoscale atmospheric processes. These space measurements and conventional observational data are being processed together to gain an improved understanding of the mesoscale structure and the dynamical evolution of the atmosphere relative to cloud development and precipitation processes. To satisfy its vast data processing requirements, the ASD has developed a Researcher Computer System consiting of three primary computer systems which provides over 20 scientists with a wide range of capabilities for processing and displaying a large volumes of remote sensing data. Each of the computers performs a specific function according to its unique capabilities.

EarthCube: A Community-Driven Cyberinfrastructure for the Geosciences

NASA Astrophysics Data System (ADS)

Koskela, Rebecca; Ramamurthy, Mohan; Pearlman, Jay; Lehnert, Kerstin; Ahern, Tim; Fredericks, Janet; Goring, Simon; Peckham, Scott; Powers, Lindsay; Kamalabdi, Farzad; Rubin, Ken; Yarmey, Lynn

2017-04-01

EarthCube is creating a dynamic, System of Systems (SoS) infrastructure and data tools to collect, access, analyze, share, and visualize all forms of geoscience data and resources, using advanced collaboration, technological, and computational capabilities. EarthCube, as a joint effort between the U.S. National Science Foundation Directorate for Geosciences and the Division of Advanced Cyberinfrastructure, is a quickly growing community of scientists across all geoscience domains, as well as geoinformatics researchers and data scientists. EarthCube has attracted an evolving, dynamic virtual community of more than 2,500 contributors, including earth, ocean, polar, planetary, atmospheric, geospace, computer and social scientists, educators, and data and information professionals. During 2017, EarthCube will transition to the implementation phase. The implementation will balance "innovation" and "production" to advance cross-disciplinary science goals as well as the development of future data scientists. This presentation will describe the current architecture design for the EarthCube cyberinfrastructure and implementation plan.

Lewis materials research and technology: An overview

NASA Technical Reports Server (NTRS)

Grisaffe, Salvatore J.

1987-01-01

The Materials Division at the Lewis Research Center has a long record of contributions to both materials and process technology as well as to the understanding of key high-temperature phenomena. An overview of the division staff, facilities, past history, recent progress, and future interests is presented.

32 CFR 776.12 - Maintenance of files.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Research and Civil Law Branch, JA Division, HQMC. (a) Requests for access to such records should be..., Judge Advocate Research and Civil Law Branch, JA Division, Headquarters Marine Corps, Washington Navy... § 776.12 Maintenance of files. Ethics complaint records shall be maintained by the Administrative Law...

32 CFR 776.12 - Maintenance of files.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Research and Civil Law Branch, JA Division, HQMC. (a) Requests for access to such records should be..., Judge Advocate Research and Civil Law Branch, JA Division, Headquarters Marine Corps, Washington Navy... § 776.12 Maintenance of files. Ethics complaint records shall be maintained by the Administrative Law...

32 CFR 776.12 - Maintenance of files.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Research and Civil Law Branch, JA Division, HQMC. (a) Requests for access to such records should be..., Judge Advocate Research and Civil Law Branch, JA Division, Headquarters Marine Corps, Washington Navy... § 776.12 Maintenance of files. Ethics complaint records shall be maintained by the Administrative Law...

32 CFR 776.12 - Maintenance of files.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Research and Civil Law Branch, JA Division, HQMC. (a) Requests for access to such records should be..., Judge Advocate Research and Civil Law Branch, JA Division, Headquarters Marine Corps, Washington Navy... § 776.12 Maintenance of files. Ethics complaint records shall be maintained by the Administrative Law...

32 CFR 776.12 - Maintenance of files.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Research and Civil Law Branch, JA Division, HQMC. (a) Requests for access to such records should be..., Judge Advocate Research and Civil Law Branch, JA Division, Headquarters Marine Corps, Washington Navy... § 776.12 Maintenance of files. Ethics complaint records shall be maintained by the Administrative Law...

77 FR 12318 - National Cancer Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-29

... Research in Integrative Cancer Biology and the Tumor Microenvironment. Date: March 20, 2012. Time: 8 a.m... Review Officer, Special Review & Logistics Branch, Division of Extramural Activities, National Cancer...: Ilda M McKenna, Ph.D., Scientific Review Officer, Research Training Review Branch, Division of...

75 FR 79049 - Notice of Issuance of Regulatory Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-17

..., Division of Engineering, Office of Nuclear Regulatory Research, U.S. Nuclear Regulatory Commission... INFORMATION: I. Introduction The U.S. Nuclear Regulatory Commission (NRC) is issuing a revision to an existing... Development Branch, Division of Engineering, Office of Nuclear Regulatory Research. [FR Doc. 2010-31731 Filed...

Cognitive and Neural Sciences Division, 1988 Programs.

ERIC Educational Resources Information Center

Vaughan, Willard S., Ed.

The research and development efforts performed by principal investigators under sponsorship of the Office of Naval Research Cognitive and Neural Sciences Division during 1988 are documented. The title, name and affiliation of the principal investigator, project code, contract number, current end date, technical objective, approach, and progress of…

75 FR 66772 - National Heart, Lung, and Blood Institute; Notice of Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-29

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and..., Director, National Center on Sleep Disorders Research, Division of Lung Diseases, National Heart, Lung, and... Sleep Disorders Research, Division of Lung Diseases, National Heart, Lung, and Blood Institute, National...

Clinical Trials Management | Division of Cancer Prevention

Cancer.gov

Information for researchers about developing, reporting, and managing NCI-funded cancer prevention clinical trials. Protocol Information Office The central clearinghouse for clinical trials management within the Division of Cancer Prevention.Read more about the Protocol Information Office. | Information for researchers about developing, reporting, and managing NCI-funded

21 CFR 1.101 - Notification and recordkeeping.

Code of Federal Regulations, 2011 CFR

2011-04-01

... products and devices regulated by the Center for Biologics Evaluation and Research—Division of Case... Research, Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville, MD 20852-1448. (ii) For... Research—Division of New Drugs and Labeling Compliance, Center for Drug Evaluation and Research, Food and...

21 CFR 1.101 - Notification and recordkeeping.

Code of Federal Regulations, 2010 CFR

2010-04-01

... products and devices regulated by the Center for Biologics Evaluation and Research—Division of Case... Research, Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville, MD 20852-1448. (ii) For... Research—Division of New Drugs and Labeling Compliance, Center for Drug Evaluation and Research, Food and...

Groundwater Technical Support Center (GWTSC) Annual Report Fiscal Year 2016 (FY16)

EPA Science Inventory

The Groundwater Technical Support Center (GWTSC) is part of the Groundwater, Watershed, and Ecosystem Restoration Division (GWERD), which is based in the Robert S. Kerr Environmental Research Center in Ada, Oklahoma. The GWERD is a research division of EPA’s National Risk M...

Lessons from bacterial homolog of tubulin, FtsZ for microtubule dynamics.

PubMed

Battaje, Rachana Rao; Panda, Dulal

2017-09-01

FtsZ, a homolog of tubulin, is found in almost all bacteria and archaea where it has a primary role in cytokinesis. Evidence for structural homology between FtsZ and tubulin came from their crystal structures and identification of the GTP box. Tubulin and FtsZ constitute a distinct family of GTPases and show striking similarities in many of their polymerization properties. The differences between them, more so, the complexities of microtubule dynamic behavior in comparison to that of FtsZ, indicate that the evolution to tubulin is attributable to the incorporation of the complex functionalities in higher organisms. FtsZ and microtubules function as polymers in cell division but their roles differ in the division process. The structural and partial functional homology has made the study of their dynamic properties more interesting. In this review, we focus on the application of the information derived from studies on FtsZ dynamics to study microtubule dynamics and vice versa. The structural and functional aspects that led to the establishment of the homology between the two proteins are explained to emphasize the network of FtsZ and microtubule studies and how they are connected. © 2017 Society for Endocrinology.

Dynamics of Cell Ensembles on Adhesive Micropatterns: Bridging the Gap between Single Cell Spreading and Collective Cell Migration

PubMed Central

Albert, Philipp J.; Schwarz, Ulrich S.

2016-01-01

The collective dynamics of multicellular systems arise from the interplay of a few fundamental elements: growth, division and apoptosis of single cells; their mechanical and adhesive interactions with neighboring cells and the extracellular matrix; and the tendency of polarized cells to move. Micropatterned substrates are increasingly used to dissect the relative roles of these fundamental processes and to control the resulting dynamics. Here we show that a unifying computational framework based on the cellular Potts model can describe the experimentally observed cell dynamics over all relevant length scales. For single cells, the model correctly predicts the statistical distribution of the orientation of the cell division axis as well as the final organisation of the two daughters on a large range of micropatterns, including those situations in which a stable configuration is not achieved and rotation ensues. Large ensembles migrating in heterogeneous environments form non-adhesive regions of inward-curved arcs like in epithelial bridge formation. Collective migration leads to swirl formation with variations in cell area as observed experimentally. In each case, we also use our model to predict cell dynamics on patterns that have not been studied before. PMID:27054883

Universal rule for the symmetric division of plant cells

PubMed Central

Besson, Sébastien; Dumais, Jacques

2011-01-01

The division of eukaryotic cells involves the assembly of complex cytoskeletal structures to exert the forces required for chromosome segregation and cytokinesis. In plants, empirical evidence suggests that tensional forces within the cytoskeleton cause cells to divide along the plane that minimizes the surface area of the cell plate (Errera’s rule) while creating daughter cells of equal size. However, exceptions to Errera’s rule cast doubt on whether a broadly applicable rule can be formulated for plant cell division. Here, we show that the selection of the plane of division involves a competition between alternative configurations whose geometries represent local area minima. We find that the probability of observing a particular division configuration increases inversely with its relative area according to an exponential probability distribution known as the Gibbs measure. Moreover, a comparison across land plants and their most recent algal ancestors confirms that the probability distribution is widely conserved and independent of cell shape and size. Using a maximum entropy formulation, we show that this empirical division rule is predicted by the dynamics of the tense cytoskeletal elements that lead to the positioning of the preprophase band. Based on the fact that the division plane is selected from the sole interaction of the cytoskeleton with cell shape, we posit that the new rule represents the default mechanism for plant cell division when internal or external cues are absent. PMID:21383128

Noise and Epigenetic Inheritance of Single-Cell Division Times Influence Population Fitness.

PubMed

Cerulus, Bram; New, Aaron M; Pougach, Ksenia; Verstrepen, Kevin J

2016-05-09

The fitness effect of biological noise remains unclear. For example, even within clonal microbial populations, individual cells grow at different speeds. Although it is known that the individuals' mean growth speed can affect population-level fitness, it is unclear how or whether growth speed heterogeneity itself is subject to natural selection. Here, we show that noisy single-cell division times can significantly affect population-level growth rate. Using time-lapse microscopy to measure the division times of thousands of individual S. cerevisiae cells across different genetic and environmental backgrounds, we find that the length of individual cells' division times can vary substantially between clonal individuals and that sublineages often show epigenetic inheritance of division times. By combining these experimental measurements with mathematical modeling, we find that, for a given mean division time, increasing heterogeneity and epigenetic inheritance of division times increases the population growth rate. Furthermore, we demonstrate that the heterogeneity and epigenetic inheritance of single-cell division times can be linked with variation in the expression of catabolic genes. Taken together, our results reveal how a change in noisy single-cell behaviors can directly influence fitness through dynamics that operate independently of effects caused by changes to the mean. These results not only allow a better understanding of microbial fitness but also help to more accurately predict fitness in other clonal populations, such as tumors. Copyright © 2016 Elsevier Ltd. All rights reserved.

Summaries of FY 92 geosciences research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-12-01

The Department of Energy supports research in the geosciences in order to provide a sound foundation of fundamental knowledge in those areas of the geosciences that are germane to the Department of Energy's many missions. The Division of Engineering and Geosciences, part of the Office of Basic Energy Sciences of the Office of Energy Research, supports the Geosciences Research Program. The participants in this program include Department of Energy laboratories, academic institutions, and other governmental agencies. These activities are formalized by a contract or grant between the Department of Energy and the organization performing the work, providing funds for salaries,more » equipment, research materials, and overhead. The summaries in this document, prepared by the investigators, describe the scope of the individual programs. The Geosciences Research Program includes research in geophysics, geochemistry, resource evaluation, solar-terrestrial interactions and their subdivisions including Earth dynamics, properties of Earth materials, rock mechanics, underground imaging, rock-fluid interactions, continental scientific drilling, geochemical transport, solar/atmospheric physics, and modeling, with emphasis on the interdisciplinary areas. All such research is related either directly or indirectly to the Department of Energy's long-range technological needs.« less

IFLA General Conference, 1992. Division of General Research Libraries: Section on National Libraries; Section on Parliamentary Libraries; Section on University Libraries and Other General Research Libraries. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations and Institutions, London (England).

Fifteen papers delivered for the Division of General Research Libraries at the 1992 International Federation of Library Associations and Institutions annual meeting are presented. These papers deal with national libraries, parliamentary (legislative) libraries, and university libraries. The papers are: (1) "Seeking Alternatives to National…

The John Milner Nutrition and Cancer Prevention Research Practicum | Division of Cancer Prevention

Cancer.gov

The Nutritional Science Research Group in the Division of Cancer Prevention at the National Cancer Institute, National Institutes of Health and the Department of Nutrition at the Clinical Center, National Institutes of Health, and the U.S. Department of Agriculture’s Beltsville Human Nutrition Research Center are offering a one-week educational opportunity in Nutrition and

The John Milner Nutrition and Cancer Prevention Research Practicum | Division of Cancer Prevention

Cancer.gov

The Nutritional Science Research Group in the Division of Cancer Prevention at the National Cancer Institute, National Institutes of Health and the Department of Nutrition at the Clinical Center, National Institutes of Health, and the U.S. Department of Agriculture’s (U.S.D.A.) Beltsville Human Nutrition Research Center are offering a one-week educational opportunity in

A Case Study of Faculty Development Programs in Division I Research Institution Colleges: The Perspective of the Program Administrators

ERIC Educational Resources Information Center

FitzSimmons, Jason

2010-01-01

The purpose of this study was to investigate faculty development from the perspectives of program administrators in different colleges of a Division I research institution. The participants were administrators of faculty development programs from eight different colleges at the institution. The research questions were (a) How do the administrators…

Job Opening for Medical Officer in DCP’s Breast and Gynecologic Cancer Research Group | Division of Cancer Prevention

Cancer.gov

The Breast and Gynecologic Cancer Research Group (BGCRG), Division of Cancer Prevention (DCP), National Cancer Institute (NCI), has an opening for an experienced Medical Officer. BGCRG focuses on fostering the development and conduct of research on the prevention and early detection of breast cancer, cervix and human papillomavirus (HPV)-related cancers, endometrial cancers,

THE IMPORTANCE OF A SUCCESSFUL QUALITY ASSURANCE (QA) PROGRAM FROM A RESEARCH MANAGER'S PERSPECTIVE

EPA Science Inventory

The paper discusses the Air Pollution Prevention and Control Division's Quality Assurance (QA) program and the approaches used to meet QA requirements in the Division. The presentation is a technical manager's perspective of the Division's requirements for and approach to QA in i...

The Application of SERS (Surface Enhanced Raman Scattering) to Study Surface Oxidation Reactions of Phosphonates.

DTIC Science & Technology

1988-02-15

Center Attn: Dr. Ron Atkins Code 50C Chemistry Division Crane, Indiana 47522-5050 China Lake, California 93555 Scientific Advisor INaval Civil...Superintendent Marine Sciences Division Chemistry Division, Code 6100 San Diego, California 91232 Naval Research Laboratory Washington, D.C. 20375-5000 ,! .1

Division site selection in Escherichia coli involves dynamic redistribution of Min proteins within coiled structures that extend between the two cell poles

NASA Astrophysics Data System (ADS)

Shih, Yu-Ling; Le, Trung; Rothfield, Lawrence

2003-06-01

The MinCDE proteins of Escherichia coli are required for proper placement of the division septum at midcell. The site selection process requires the rapid oscillatory redistribution of the proteins from pole to pole. We report that the three Min proteins are organized into extended membrane-associated coiled structures that wind around the cell between the two poles. The pole-to-pole oscillation of the proteins reflects oscillatory changes in their distribution within the coiled structure. We also report that the E. coli MreB protein, which is required for maintaining the rod shape of the cell, also forms extended coiled structures, which are similar to the MreB structures that have previously been reported in Bacillus subtilis. The MreB and MinCDE coiled arrays do not appear identical. The results suggest that at least two functionally distinct cytoskeletal-like elements are present in E. coli and that structures of this type can undergo dynamic changes that play important roles in division site placement and possibly other aspects of the life of the cell.

Bulletin of the Division of Electrical Engineering, 1987-1988, volume 3, number 2

NASA Astrophysics Data System (ADS)

1988-05-01

A report is provided on the activities of the Division of Electrical Engineering of the National Research Council of Canada. The Division engages in the development of standards and test procedures, and undertakes applied research in support of Canadian industry, government departments, and universities. Technology transfer and collaborative research continue to grow in importance as focuses of Division activities. The Division is comprised of three sections: the Laboratory for Biomedical Engineering, the Laboratory for Electromagnetic and Power Engineering, and the Laboratory for Intelligent Systems. An agreement has been reached to commercially exploit the realtime multiprocessor operating system Harmony. The dielectrics group has made contract research agreements with industry from both Canada and the United States. The possibility of employing a new advanced laser vision camera, which can be mounted on a robot arm in a variety of industrial applications is being explored. Potential short-term spinoffs related to intelligent wheelchairs are being sought as part of the new interlaboratory program which has as its long-term objective the development of a mobile robot for health care applications. A program in applied artificial intelligence has been established. Initiatives in collaboration with outside groups include proposals for major institutes in areas ranging from police and security research to rehabilitation research, programs to enhance Canadian industrial competence working with the Canadian Manufacturers' Association and other government departments, and approaches to the utilization of existing facilities which will make them more valuable without significant financial expenditures.

Impact Properties of Metal Fan Containment Materials Being Evaluated for the High-Speed Civil Transport (HSCT)

NASA Technical Reports Server (NTRS)

1996-01-01

Under the Enabling Propulsion Materials (EPM) program - a partnership between NASA, Pratt & Whitney, and GE Aircraft Engines - the Materials and Structures Divisions of the NASA Lewis Research Center are involved in developing a fan-containment system for the High-Speed Civil Transport (HSCT). The program calls for a baseline system to be designed by the end of 1995, with subsequent testing of innovative concepts. Five metal candidate materials are currently being evaluated for the baseline system in the Structures Division's Ballistic Impact Facility. This facility was developed to provide the EPM program with cost-efficient and timely impact test data. At the facility, material specimens are impacted at speeds up to 350 m/sec by projectiles of various sizes and shapes to assess the specimens' ability to absorb energy and withstand impact. The tests can be conducted at either room or elevated temperatures. Posttest metallographic analysis is conducted to improve understanding of the failure modes. A dynamic finite element program is used to simulate the events and both guide the testing as well as aid in designing the fan-containment system.

Phase-Division-Based Dynamic Optimization of Linkages for Drawing Servo Presses

NASA Astrophysics Data System (ADS)

Zhang, Zhi-Gang; Wang, Li-Ping; Cao, Yan-Ke

2017-11-01

Existing linkage-optimization methods are designed for mechanical presses; few can be directly used for servo presses, so development of the servo press is limited. Based on the complementarity of linkage optimization and motion planning, a phase-division-based linkage-optimization model for a drawing servo press is established. Considering the motion-planning principles of a drawing servo press, and taking account of work rating and efficiency, the constraints of the optimization model are constructed. Linkage is optimized in two modes: use of either constant eccentric speed or constant slide speed in the work segments. The performances of optimized linkages are compared with those of a mature linkage SL4-2000A, which is optimized by a traditional method. The results show that the work rating of a drawing servo press equipped with linkages optimized by this new method improved and the root-mean-square torque of the servo motors is reduced by more than 10%. This research provides a promising method for designing energy-saving drawing servo presses with high work ratings.

Analytical Chemistry Division annual progress report for period ending December 31, 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The Analytical Chemistry Division of Oak Ridge National Laboratory (ORNL) is a large and diversified organization. As such, it serves a multitude of functions for a clientele that exists both in and outside of ORNL. These functions fall into the following general categories: (1) Analytical Research, Development, and Implementation. The division maintains a program to conceptualize, investigate, develop, assess, improve, and implement advanced technology for chemical and physicochemical measurements. Emphasis is on problems and needs identified with ORNL and Department of Energy (DOE) programs; however, attention is also given to advancing the analytical sciences themselves. (2) Programmatic Research, Development, andmore » Utilization. The division carries out a wide variety of chemical work that typically involves analytical research and/or development plus the utilization of analytical capabilities to expedite programmatic interests. (3) Technical Support. The division performs chemical and physicochemical analyses of virtually all types. The Analytical Chemistry Division is organized into four major sections, each of which may carry out any of the three types of work mentioned above. Chapters 1 through 4 of this report highlight progress within the four sections during the period January 1 to December 31, 1988. A brief discussion of the division's role in an especially important environmental program is given in Chapter 5. Information about quality assurance, safety, and training programs is presented in Chapter 6, along with a tabulation of analyses rendered. Publications, oral presentations, professional activities, educational programs, and seminars are cited in Chapters 7 and 8.« less

Modeling and simulation of dynamic ant colony's labor division for task allocation of UAV swarm

NASA Astrophysics Data System (ADS)

Wu, Husheng; Li, Hao; Xiao, Renbin; Liu, Jie

2018-02-01

The problem of unmanned aerial vehicle (UAV) task allocation not only has the intrinsic attribute of complexity, such as highly nonlinear, dynamic, highly adversarial and multi-modal, but also has a better practicability in various multi-agent systems, which makes it more and more attractive recently. In this paper, based on the classic fixed response threshold model (FRTM), under the idea of "problem centered + evolutionary solution" and by a bottom-up way, the new dynamic environmental stimulus, response threshold and transition probability are designed, and a dynamic ant colony's labor division (DACLD) model is proposed. DACLD allows a swarm of agents with a relatively low-level of intelligence to perform complex tasks, and has the characteristic of distributed framework, multi-tasks with execution order, multi-state, adaptive response threshold and multi-individual response. With the proposed model, numerical simulations are performed to illustrate the effectiveness of the distributed task allocation scheme in two situations of UAV swarm combat (dynamic task allocation with a certain number of enemy targets and task re-allocation due to unexpected threats). Results show that our model can get both the heterogeneous UAVs' real-time positions and states at the same time, and has high degree of self-organization, flexibility and real-time response to dynamic environments.

Energy Division annual progress report for period ending September 30, 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This report covers work done during FY 1983 by the staff of the Energy Division and its subcontractors and by colleagues in other Oak Ridge National Laboratory divisions working on Energy Division projects. The work can be divided into four areas: (1) analysis and assessment, (2) models and data systems, (3) research to improve the efficiency of energy use and to improve electric power transmission and distribution, and (4) research utilization. Support came principally from the US Department of Energy (DOE), the US Nuclear Regulatory Commission, and the US Department of Defense, but also from a number of other agenciesmore » and organizations. Analysis and assessment included work on (a) environmental issues, including those deriving from the preparation of environmental impact statements; (b) energy and resource analysis; and (c) emergency preparedness. The models and data systems area involved research on evaluating and developing energy, environment, and engineering simulation models and on devising large data management systems, evaluating user data requirements, and compiling data bases. Research on improving the efficiency of energy use was focused primarily on the buildings and electricity sectors. A major effort on heat pump technology, which includes both heat-activated and electrically driven systems, continues. An important aspect of all the work was research utilization. Since the Energy Division is doing applied research, results are, by definition, intended to solve problems or answer questions of DOE and other sponsors. However, there are other users, and research utilization activities include technology transfer, commercialization efforts, outreach to state and regional organizations, and, of course, information dissemination.« less

Neutron Diffraction Studies of Carbonate Apatite

NASA Astrophysics Data System (ADS)

Moghaddam, Hadi Y.; Leventouri, Theodora; Chakoumakos, Bryan C.

1998-11-01

Moghaddam H.Y., Leventouri Th.* (Dept. of Physics & Alloy Research Center, Florida Atlantic Univ.) Chakoumakos B.C. (Solid State Division, Oak Ridge National Lab.**,kou@ornl.gov) We report Rietveld structural refinements of neutron diffraction data of a highly crystalline, single-phase natural carbonate apatite,(francolite of Epirus, Greece), in order to elucidate the details of carbonate substitution in the apatites. The composition is Ca9.56Na0.38Mg0.08(PO4)4.82(CO3)0.946(SO4)0.2F2.34, as determined by electron microprobe analysis. We report refinements of data for the native francolite as a function of temperature between 296K and 10K after the material had been heated at 750 °C to drive off adsorbed water and CO2. The neutron diffractioii@data were collected using a wavelength 1.0912 A on the HB4 high resolution powder diffractometer at the High Flux Isotope Reactor at Oak Ridge National Laboratory. Analysis of the temperature dependence of the anisotropic displacement parameters can reveal the contribution from the temperature independent static positional disorder. Difference displacement parameters evaluated along various bonding directions are being used to describe the mechanics and dynamics of the carbonate for phosphate substitution.*Supported by a SURA-ORNL Summer Cooperative Research Program 1998.**Supported by the Division of Materials Sciences,U.S. D.O.E. (contract DE-AC05-96OR22464 with Lockheed Martin Energy Research Corporation).

Research and technology plans for FY 1989 and accomplishments for FY 1988. [Structural Mechanics Division

NASA Technical Reports Server (NTRS)

Bales, Kay S.

1989-01-01

The Objectives, FY 1989 Plans, Approach, and FY 1989 Milestones for the Structural Mechanics Division's research programs are presented. Fiscal year 1988 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

Home | Division of Cancer Prevention

Cancer.gov

Our Research The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into cancer. |

The Construction of Academic Time: Sub/Contracting Academic Labour in Research.

ERIC Educational Resources Information Center

Hey, Valerie

2001-01-01

Offers a poststructuralist analysis of the UK higher education sector's academic division of labor, exploring some new contradictions from a contract researcher's standpoint. Raises political, social, and methodological questions about these divisions by exploring their class and gender dimensions. Too many academics remain silent about adverse…

Ground Water Technical Support Center (GWTSC) Annual Report Fiscal Year 2014 (FY14)

EPA Science Inventory

The Ground Water Technical Support Center (GWTSC) is part of the Ground Water and Ecosystems Restoration Division (GWERD), which is based in the Robert S. Kerr Environmental Research Center in Ada, Oklahoma. The GWERD is a research division of U.S. EPA's National Risk Management...

Ground Water Technical Support Center (GWTSC) Annual Report Fiscal Year 2015

EPA Science Inventory

The Ground Water Technical Support Center (GWTSC) is part of the Ground Water and Ecosystems Restoration Division (GWERD), which is based in the Robert S. Kerr Environmental Research Center in Ada, Oklahoma. The GWERD is a research division of U.S. EPA’s National Risk Management ...

Structural Mechanics Division research and technology plans for FY 1990 and accomplishments for FY 1989

NASA Technical Reports Server (NTRS)

Bales, Kay S.

1990-01-01

The Objectives, FY 1990 Plans, Approach, and FY 1990 Milestones for the Structural Mechanics Division's research programs are presented. FY 1989 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

75 FR 41551 - Meetings of Humanities Panel

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-16

... Psychology in Fellowships, submitted to the Division of Research Programs at the May 4, 2010 deadline. 21... applications for Advanced Social Science Research on Japan in Fellowships, submitted to the Division of...:30 a.m. to 5 p.m. Room: 415. Program: This meeting will review applications for Social Sciences and...

Cognitive and Neural Sciences Division, 1989 Programs.

ERIC Educational Resources Information Center

Vaughan, Willard S., Ed.

This report documents research and development performed by principal investigators under the sponsorship of the Office of Naval Research Cognitive and Neural Sciences Division during fiscal year 1989. Programs are conducted under contracts and grants awarded on the basis of proposals received in response to a Broad Agency Announcement in the…

77 FR 14534 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-12

... Disorders and Stroke Special Emphasis Panel, NIH Blueprint for Neuroscience. Date: March 28, 2012. Time: 8 a... Officer, Scientific Review Branch, Division of Extramural Research, NINDS/NIH/DHHS/Neuroscience Center..., Division of Extramural Research, NINDS/NIH/DHHS/Neuroscience Center, 6001 Executive Blvd., Suite 3208, MSC...

research_group | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Spatial Ability Improvement and Curriculum Content

ERIC Educational Resources Information Center

Connolly, Patrick E.

2009-01-01

There has been a significant history of research on spatial ability and visualization improvement and related curriculum content presented by members of the Engineering Design Graphics Division over the past decade. Recently, interest in this topic has again been heightened thanks to the work of several division members on research such as the…

Diverse behaviors of outer radial glia in developing ferret and human cortex.

PubMed

Gertz, Caitlyn C; Lui, Jan H; LaMonica, Bridget E; Wang, Xiaoqun; Kriegstein, Arnold R

2014-02-12

The dramatic increase in neocortical size and folding during mammalian brain evolution has been attributed to the elaboration of the subventricular zone (SVZ) and the associated increase in neural progenitors. However, recent studies have shown that SVZ size and the abundance of resident progenitors do not directly predict cortical topography, suggesting that complex behaviors of the progenitors themselves may contribute to the overall size and shape of the adult cortex. Using time-lapse imaging, we examined the dynamic behaviors of SVZ progenitors in the ferret, a gyrencephalic carnivore, focusing our analysis on outer radial glial cells (oRGs). We identified a substantial population of oRGs by marker expression and their unique mode of division, termed mitotic somal translocation (MST). Ferret oRGs exhibited diverse behaviors in terms of division location, cleavage angle, and MST distance, as well as fiber orientation and dynamics. We then examined the human fetal cortex and found that a subset of human oRGs displayed similar characteristics, suggesting that diversity in oRG behavior may be a general feature. Similar to the human, ferret oRGs underwent multiple rounds of self-renewing divisions but were more likely to undergo symmetric divisions that expanded the oRG population, as opposed to producing intermediate progenitor cells (IPCs). Differences in oRG behaviors, including proliferative potential and daughter cell fates, may contribute to variations in cortical structure between mammalian species.

Principles of Training in Marine Corps Task Analysis. Training Manual 1

DTIC Science & Technology

1975-12-01

Training Research Programs Psychological Sciences Division Office of Naval Research Contract No. N00014-74-A-0436-0001 NR 151-370 Approved for...and Training Research Programs Psychological Sciences Division Office of Naval Research Contract No. N00014-74-A-0436-0001 NR 151-370 Approved... psychological reward; the trainee loses the connection between performance and the pat on the back that is its consequence. DIMENSIONS OF THE TRAINING

Guidelines for Research Planning and Design in Task Analysis

DTIC Science & Technology

1975-09-01

Personnel and Training Research Programs Psychological Sciences Division Office of Naval Research Contract No. N00014-74-A-0436-0001 NR 151-370...Programs Psychological Sciences Division Office of Naval Research Contract No. N00014-74-A-0436-0001 NR 151-370 Approved for public release...for ways in which the hypothesis can be tested . There are 11 several ways to do this and they are often used jointly. 1* Review of the Literature

New Directions in NASA's Materials Science Program

NASA Technical Reports Server (NTRS)

Gillies, Donald C.; Whitaker, Ann F. (Technical Monitor)

2001-01-01

Recently, NASA's Microgravity Research Division was re-aligned to match the Agency's increasing awareness of the importance of biological and nano-structural sciences. The Division has become the Physical Sciences Research section within the newly created Office of Biological and Physical Research. Within materials science and in the last few years, new programs aimed at biomaterials have been initiated. Results from these programs and also new research pertaining to materials for radiation protection will be discussed.

Dynamic self-organisation of haematopoiesis and (a)symmetric cell division.

PubMed

Måløy, Marthe; Måløy, Frode; Jakobsen, Per; Olav Brandsdal, Bjørn

2017-02-07

A model of haematopoiesis that links self-organisation with symmetric and asymmetric cell division is presented in this paper. It is assumed that all cell divisions are completely random events, and that the daughter cells resulting from symmetric and asymmetric stem cell divisions are, in general, phenotypically identical, and still, the haematopoietic system has the flexibility to self-renew, produce mature cells by differentiation, and regenerate undifferentiated and differentiated cells when necessary, due to self-organisation. As far as we know, no previous model implements symmetric and asymmetric division as the result of self-organisation. The model presented in this paper is inspired by experiments on the Drosophila germline stem cell, which imply that under normal conditions, the stem cells typically divide asymmetrically, whereas during regeneration, the rate of symmetric division increases. Moreover, the model can reproduce several of the results from experiments on female Safari cats. In particular, the model can explain why significant fluctuation in the phenotypes of haematopoietic cells was observed in some cats, when the haematopoietic system had reached normal population level after regeneration. To our knowledge, no previous model of haematopoiesis in Safari cats has captured this phenomenon. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Functional redundancy of division specific penicillin-binding proteins in Bacillus subtilis.

PubMed

Sassine, Jad; Xu, Meizhu; Sidiq, Karzan R; Emmins, Robyn; Errington, Jeff; Daniel, Richard A

2017-10-01

Bacterial cell division involves the dynamic assembly of a diverse set of proteins that coordinate the invagination of the cell membrane and synthesis of cell wall material to create the new cell poles of the separated daughter cells. Penicillin-binding protein PBP 2B is a key cell division protein in Bacillus subtilis proposed to have a specific catalytic role in septal wall synthesis. Unexpectedly, we find that a catalytically inactive mutant of PBP 2B supports cell division, but in this background the normally dispensable PBP 3 becomes essential. Phenotypic analysis of pbpC mutants (encoding PBP 3) shows that PBP 2B has a crucial structural role in assembly of the division complex, independent of catalysis, and that its biochemical activity in septum formation can be provided by PBP 3. Bioinformatic analysis revealed a close sequence relationship between PBP 3 and Staphylococcus aureus PBP 2A, which is responsible for methicillin resistance. These findings suggest that mechanisms for rescuing cell division when the biochemical activity of PBP 2B is perturbed evolved prior to the clinical use of β-lactams. © 2017 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.

Instrumentation and Controls Division progress report for the period July 1, 1986 to June 30, 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klobe, L.E.

1988-12-01

The Instrumentation and Controls (IandC) Division of Oak Ridge National Laboratory (ORNL) performs basic and applied instrumentation and controls research, development and design engineering, specialized instrument design and fabrication, and maintenance services for instruments, electronics, and computers. The IandC Division is one of the largest RandD organizations of its type among government laboratories, and it exists as the result of an organizational strategy to integrate ORNL's instrumentation and controls-related disciplines into one dedicated functional organization to increase the Laboratory's expertise and capabilities in these rapidly expanding, innovative areas of technology. The Division participates in the programs and projects of ORNLmore » by applying its expertise and capabilities in concert with other divisions to perform basic research and mission-oriented technology development. Many of the Division's RandD tasks that are a part of a larger ORNL program are of sufficient scope that the IandC effort constitutes a separate program element with direct funding and management responsibility within the Division. The activities of IandC include performance of an RandD task in IandC facilities, the participation of from one of many IandC engineers and scientists in a multidisciplinary team working in a specific research area or development project, design and fabrication of a special instrument or instrumentation system, or a few hours of maintenance service. In its support and maintenance work, the role of the IandC Division is to provide a level of expertise appropriate to complete a job successfully at minimum overall cost and time schedule---a role which involves IandC in almost all ORNL activities.« less

Cytoplasmic removal, enucleation, and cell fusion of mouse oocytes.

PubMed

Kyogoku, Hirohisa; Yoshida, Shuhei; Kitajima, Tomoya S

2018-01-01

Meiotic divisions in females occur in fully grown oocytes that have a large cytoplasmic volume. The intracellular processes that are needed to accomplish meiotic divisions, such as spindle formation, chromosome segregation, and polar body extrusion, are controlled by the concerted actions of nuclear and cytoplasmic factors, which exhibit dynamic quantitative and spatiotemporal changes during meiotic maturation. Thus, distinguishing between meiotic controls that are mediated by cytoplasmic factors and those mediated by nuclear factors helps in the understanding of the mechanisms underlying meiotic divisions. Here, we describe a method to artificially modify the number of nuclei and the volume of the cytoplasm of mouse oocytes through cytoplasmic removal, enucleation, and cell fusion. The oocytes generated by this method are viable and undergo reproducible meiotic divisions exhibiting the effects of altered amounts of cytoplasmic and nuclear factors, which can be analyzed by various assays, such as live imaging microscopy. © 2018 Elsevier Inc. All rights reserved.

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells.

PubMed

Lewis, Samantha C; Uchiyama, Lauren F; Nunnari, Jodi

2016-07-15

Mitochondrial DNA (mtDNA) encodes RNAs and proteins critical for cell function. In human cells, hundreds to thousands of mtDNA copies are replicated asynchronously, packaged into protein-DNA nucleoids, and distributed within a dynamic mitochondrial network. The mechanisms that govern how nucleoids are chosen for replication and distribution are not understood. Mitochondrial distribution depends on division, which occurs at endoplasmic reticulum (ER)-mitochondria contact sites. These sites were spatially linked to a subset of nucleoids selectively marked by mtDNA polymerase and engaged in mtDNA synthesis--events that occurred upstream of mitochondrial constriction and division machine assembly. Our data suggest that ER tubules proximal to nucleoids are necessary but not sufficient for mtDNA synthesis. Thus, ER-mitochondria contacts coordinate licensing of mtDNA synthesis with division to distribute newly replicated nucleoids to daughter mitochondria. Copyright © 2016, American Association for the Advancement of Science.

Publications on acoustics research at the Langley Research Center during 1980-1986

NASA Technical Reports Server (NTRS)

Sutherland, Linda W. (Compiler)

1988-01-01

This report is a compilation of publications from acoustics research at the Langley Research Center. The reports are listed in chronological order and summarize the written output of the Acoustics Division and its predecessor, The Acoustics and Noise Reduction Division, for the period 1980 through 1986. The information assembled has been extracted from the 1980 through 1986 issues for the Technical Memorandum entitled, Scientific and Technical Information Output of the Langley Research Center for the Calendar Year.

Nonlocal Effects of Crack Curving.

DTIC Science & Technology

1982-07-01

Structures Research Division Marine Corps Development Langley Research Center and Education Comand Langley Station Quantice , Virginia 22134i~l EaptOn, Vtiina...Advanced lomn 3C128 Research and Technology The Pentagon Washington. D.C. 2054 Washington, D.C* 20301 Air Force Dr. G Sans National Science Foundation... Science and Technology Division (FIS) Washingtono DOC* 20540 AM (XIM)Director Chief Applied Mechanics Group Defense Nuclear Agency U.S.. Air Force

Serosurveillance of Viral Pathogens Circulating in West Africa

DTIC Science & Technology

2016-05-20

Research Institute of Infectious Diseases, Fort 5 Detrick, Maryland, USA 6 7 2 Statistics Division, US Army Medical Research Institute of...17 18 19 20 21 22 * Corresponding author: 23 Randal J. Schoepp 24 Diagnostic Systems Division 25 U.S. Army Medical Research Institute...STATEMENT A: Approved for public release; distribution is unlimited. UNCLASSIFIED We used the magnetic bead-based MAGPIX® system (Luminex, Austin , TX ) to

International Federation of Library Associations Annual Conference Papers. General Research Libraries Division: Parliamentary Libraries and National Libraries Sections (47th, Leipzig, East Germany, August 17-22, 1981).

ERIC Educational Resources Information Center

Gude, Gilbert; And Others

This set of papers presented to the General Research Libraries Division of the International Federation of Library Associations (IFLA) during its 47th annual conference (1981) includes: "The Effect of the Introduction of Computers on Library and Research Staff," by Gilbert Gude; "Libraries as Information Service Agencies…

The Division of Labor in Lesbian, Gay, and Heterosexual New Adoptive Parents

ERIC Educational Resources Information Center

Goldberg, Abbie E.; Smith, JuliAnna Z.; Perry-Jenkins, Maureen

2012-01-01

Little research has investigated the division of child care and housework in adoptive or lesbian/gay parent families, yet these contexts "control for" family characteristics such as biological relatedness and parental gender differences known to be linked to family work. This study examined predictors (measured preadoption) of the division of…

Division I Men's Basketball Scholarship: The Challenges of Being a Black Male Athlete

ERIC Educational Resources Information Center

Wright, Lonnie

2015-01-01

The Qualitative research will explore issues that interface particularly with Black student- athletes on Division 1 basketball scholarships regarding academic readiness, academic support, family support and how the experience of a Division 1 scholarship impacted their lives. The population of Black student-athletes that the focus of the research…

Life Sciences Accomplishments 1994

NASA Technical Reports Server (NTRS)

Burnell, Mary Lou (Editor)

1993-01-01

The NASA Life and Biomedical Sciences and Applications Division (LBSAD) serves the Nation's life sciences community by managing all aspects of U.S. space-related life sciences research and technology development. The activities of the Division are integral components of the Nation's overall biological sciences and biomedical research efforts. However, NASA's life sciences activities are unique, in that space flight affords the opportunity to study and characterize basic biological mechanisms in ways not possible on Earth. By utilizing access to space as a research tool, NASA advances fundamental knowledge of the way in which weightlessness, radiation, and other aspects of the space-flight environment interact with biological processes. This knowledge is applied to procedures and technologies that enable humans to live and work in and explore space and contributes to the health and well-being of people on Earth. The activities of the Division are guided by the following three goals: Goal 1) Use microgravity and other unique aspects of the space environment to enhance our understanding of fundamental biological processes. Goal 2) Develop the scientific and technological foundations for supporting exploration by enabling productive human presence in space for extended periods. Goal 3) Apply our unique mission personnel, facilities, and technology to improve education, the quality of life on Earth, and U.S. competitiveness. The Division pursues these goals with integrated ground and flight programs involving the participation of NASA field centers, industry, and universities, as well as interactions with other national agencies and NASA's international partners. The published work of Division-sponsored researchers is a record of completed research in pursuit of these goals. During 1993, the LBSAD instituted significant changes in its experiment solicitation and peer review processes. For the first time, a NASA Research Announcement (NRA) was released requesting proposals for ground-based and flight research for all programs. Areas of particular interest to NASA were defined Proposals due April 29, 1994, will be peer reviewed - externally for scientific merit. This annual NRA process is now the mechanism for recruiting both extramural and intramural investigations. As an overview of LBSAD activities in 1993, this accomplishments document covers each of the major organizational components of the Division and the accomplishments of each. The second section is a review of the Space Life Sciences Research programs Space Biology, Space Physiology and Countermeasures, Radiation Health, Environmental Health, Space Human Factors, Advanced Life Support, and Global Monitoring and Disease Prediction, The third section, Research in Space Flight, describes the substantial contributions of the Spacelab Life Sciences 2 (SLS-2) mission to life sciences research and the significant contributions of the other missions flown in 1993, along with plans for future missions. The Division has greatly expanded and given high priority to its Education and Outreach Programs, which are presented in the fourth section. The fifth and final section, Partners for Space, shows the Divisions Cooperative efforts with other national and international agencies to achieve common goals, along with the accomplishments of joint research and analysis programs.

CV-990 Landing Systems Research Aircraft (LSRA) during Space Shuttle tire test

NASA Image and Video Library

1995-08-02

A NASA CV-990, modified as a Landing Systems Research Aircraft (LSRA), lands on the Edwards AFB main runway in test of the space shuttle landing gear system. In this case, the shuttle tire failed, bursting into flame during the rollout. The space shuttle landing gear test unit, operated by a high-pressure hydraulic system, allowed engineers to assess and document the performance of space shuttle main and nose landing gear systems, tires and wheel assemblies, plus braking and nose wheel steering performance. The series of 155 test missions for the space shuttle program provided extensive data about the life and endurance of the shuttle tire systems and helped raise the shuttle crosswind landing limits at Kennedy. The CV-990 used as the LSRA was built in 1962 by the Convair Division of General Dynamics Corp., Ft. Worth, Texas, served as a research aircraft at Ames Research Center, Moffett Field, California, before it came to Dryden.

Divalent Ion Parameterization Strongly Affects Conformation and Interactions of an Anionic Biomimetic Polymer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daily, Michael D.; Baer, Marcel D.; Mundy, Christopher J.

2016-03-10

The description of peptides and the use of molecular dynamics simulations to refine structures and investigate the dynamics on an atomistic scale are well developed. Through a consensus in this community over multiple decades, parameters were developed for molecular interactions that only require the sequence of amino-acids and an initial guess for the three-dimensional structure. The recent discovery of peptoids will require a retooling of the currently available interaction potentials in order to have the same level of confidence in the predicted structures and pathways as there is presently in the peptide counterparts. Here we present modeling of peptoids usingmore » a combination of ab initio molecular dynamics (AIMD) and atomistic resolution classical forcefield (FF) to span the relevant time and length scales. To properly account for the dominant forces that stabilize ordered structures of peptoids, namely steric-, electrostatic, and hydrophobic interactions mediated through sidechain-sidechain interactions in the FF model, those have to be first mapped out using high fidelity atomistic representations. A key feature here is not only to use gas phase quantum chemistry tools, but also account for solvation effects in the condensed phase through AIMD. One major challenge is to elucidate ion binding to charged or polar regions of the peptoid and its concomitant role in the creation of local order. Here, similar to proteins, a specific ion effect is observed suggesting that both the net charge and the precise chemical nature of the ion will need to be described. MDD was supported by MS3 (Materials Synthesis and Simulation Across Scales) Initiative at Pacific Northwest National Laboratory. Research was funded by the Laboratory Directed Research and Development program at Pacific Northwest National Laboratory. MDB acknowledges support from US Department of Energy, Office of Science, Office of Basic Energy Sciences, Division of Material & Engineering. CJM acknowledges support from US Department of Energy, Office of Science, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences & Biosciences. PNNL is a multiprogram national laboratory operated by Battelle for the U.S. Department of Energy.« less

Dynamic Bandwidth Allocation with Effective Utilization of Polling Interval over WDM/TDM PON

NASA Astrophysics Data System (ADS)

Ni, Cuiping; Gan, Chaoqin; Gao, Ziyue

2014-12-01

WDM/TDM (wavelength-division multiplexing/time-division multiplexing) PON (passive optical network) appears to be an attractive solution for the next generation optical access networks. Dynamic bandwidth allocation (DBA) plays a crucial role in efficiently and fairly allocating the bandwidth among all users in WDM/TDM PON. In this paper, two dynamic bandwidth allocation schemes (DBA1 and DBA2) are proposed to eliminate the idle time of polling cycles (i.e. polling interval), improve bandwidth utilization and make full use of bandwidth resources. The two DBA schemes adjust the time slot of sending request information and make fair scheduling among users to achieve the effective utilization of polling interval in WDM/TDM PON. The simulation and theoretical analyses verify that the proposed schemes outperform the conventional DBA scheme. We also make comparisons between the two schemes in terms of bandwidth utilization and average packet delay to further demonstrate the effectiveness of the scheme of DBA2.

Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump

DOE Office of Scientific and Technical Information (OSTI.GOV)

Su, Chih-Chia; Yin, Linxiang; Kumar, Nitin

2017-08-01

Resistance-nodulation-cell division efflux pumps are integral membrane proteins that catalyze the export of substrates across cell membranes. Within the hydrophobe-amphiphile efflux subfamily, these resistance-nodulation-cell division proteins largely form trimeric efflux pumps. The drug efflux process has been proposed to entail a synchronized motion between subunits of the trimer to advance the transport cycle, leading to the extrusion of drug molecules. Here we use X-ray crystallography and single-molecule fluorescence resonance energy transfer imaging to elucidate the structures and functional dynamics of the Campylobacter jejuni CmeB multidrug efflux pump. We find that the CmeB trimer displays a very unique conformation. A directmore » observation of transport dynamics in individual CmeB trimers embedded in membrane vesicles indicates that each CmeB subunit undergoes conformational transitions uncoordinated and independent of each other. On the basis of our findings and analyses, we propose a model for transport mechanism where CmeB protomers function independently within the trimer.« less

77 FR 40085 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-American Gap...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--American Gap Association Notice is hereby given that, on June 6, 2012, pursuant to...'' educational programs. Patricia A. Brink, Director of Civil Enforcement, Antitrust Division. [FR Doc. 2012...

Active Supportive and Palliative Care Research Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

NCI Community Oncology Research Program Clinical Trials | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Active NCI Community Oncology Research Program Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Supportive and Palliative Care Research Funding Opportunities | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

78 FR 63971 - Notice of Availability of Record of Decision for Outdoor Research, Development, Test and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-25

... Outdoor Research, Development, Test and Evaluation Activities at Naval Surface Warfare Center, Dahlgren Division, Dahlgren, VA AGENCY: Department of the Navy, DoD. ACTION: Notice. SUMMARY: The Department of the... proposed action, announces its decision to expand the Naval Surface Warfare Center, Dahlgren Division's...

NRCL-70, Review of the Activities of the Laboratories 1970.

ERIC Educational Resources Information Center

National Research Council of Canada, Ottawa (Ontario).

Included are descriptions of activities of each of the 12 laboratories in the National Research Council of Canada, including background information and a summary of the studies (research) and results. The 12 laboratories in the NRCL are the following: Atlantic Regional Laboratory, Biochemistry Laboratory, Division of Biology, Division of Building…

Keeping Children Safe: OJJDP's Child Protection Division.

ERIC Educational Resources Information Center

Cullen, Thomas

More than two decades of research have pointed to the connection between childhood maltreatment and delinquency. In addition, recent research confirms that harm is inflicted on children who are subjected to family and community violence. The Child Protection Division was created in an effort to bring child protection to the forefront and to…

Claire Zhu, PhD | Division of Cancer Prevention

Cancer.gov

Dr. Claire Zhu is a program director in the Early Detection Research Group of the Division of Cancer Prevention at the NCI, where she coordinates the Etiologic and Early Marker Studies Program (EEMS) in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO), as well as manages a grant portfolio in early detection research. |

Barrett's Esophagus Translational Research Network (BETRNet) | Division of Cancer Prevention

Cancer.gov

The goal of BETRNet is to reduce the incidence, morbidity, and mortality of esophageal adenocarcinoma by answering key questions related to the progression of the disease, especially in the premalignant stage. In partnership with NCI’s Division of Cancer Biology, multidisciplinary translational research centers collaborate to better understand the biology of Barrett's

Supportive and Palliative Care Research Clinical Trials | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Ground Water Technical Support Center (GWTSC) Annual Report FY 2012: October 2011 – September 2012

EPA Science Inventory

The Ground Water Technical Support Center (GWTSC) is part of the Ground Water and Ecosystems Restoration Division (GWERD), which is based in the Robert S. Kerr Environmental Research Center in Ada, Oklahoma. The GWERD is a research division of U.S. EPA's National Risk Management...

Completed Supportive and Palliative Care Research Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

77 FR 57569 - Science Advisory Board to the National Center for Toxicological Research; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-18

... overview of research activities from the NCTR Division of Bioinformatics and Computational Biology and the Division of Systems Biology. The SAB will also receive and update from the subcommittee on Immunotoxicology... advisory committee meetings and will make every effort to accommodate persons with physical disabilities or...

Computational Modeling of Laser-Cell Biochemical Interactions

DTIC Science & Technology

2010-12-31

San Antonio, TX 78228 Jeffrey W. Oliver. Ph.D. Human Effectiveness Directorate Directed Energy Bioeffects Division Optical Radiation Branch...Affairs Case No. 11-080 Air Force Research Laboratory 711 Human Performance Wing Human Effectiveness Directorate Directed Energy Bioeffects...Directed Energy Bioeffects Division Human Effectiveness Directorate 711 Human Performance Wing Air Force Research Laboratory This report is

Active Early Detection Research Network Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Active Barrett's Esophagus Translational Research Network Grants | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

77 FR 9706 - Meetings of Humanities Panel

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-17

... submitted to the Scholarly Editions grant program in the Division of Research Programs, at the December 8... Division of Research Programs, at the December 8, 2011 deadline. 3. Date: March 20, 2012. Time: 8:30 a.m. to 5 p.m. Room: 315. Program: This meeting will review applications on the subject of Philosophy and...

The Ampere and Electrical Standards

PubMed Central

Elmquist, Randolph E.; Cage, Marvin E.; Tang, Yi-hua; Jeffery, Anne-Marie; Kinard, Joseph R.; Dziuba, Ronald F.; Oldham, Nile M.; Williams, Edwin R.

2001-01-01

This paper describes some of the major contributions to metrology and physics made by the NIST Electricity Division, which has existed since 1901. It was one of the six original divisions of the National Bureau of Standards. The Electricity Division provides dc and low-frequency calibrations for industrial, scientific, and research organizations, and conducts research on topics related to electrical metrology and fundamental constants. The early work of the Electricity Division staff included the development of precision standards, such as Rosa and Thomas standard resistors and the ac-dc thermal converter. Research contributions helped define the early international system of measurement units and bring about the transition to absolute units based on fundamental principles and physical and dimensional measurements. NIST research has helped to develop and refine electrical standards using the quantum Hall effect and the Josephson effect, which are both based on quantum physics. Four projects covering a number of voltage and impedance measurements are described in detail. Several other areas of current research at NIST are described, including the use of the Internet for international compatibility in metrology, determination of the fine-structure and Planck constants, and construction of the electronic kilogram. PMID:27500018

A Simple Microscopy Assay to Teach the Processes of Phagocytosis and Exocytosis

ERIC Educational Resources Information Center

Gray, Ross; Gray, Andrew; Fite, Jessica L.; Jordan, Renee; Stark, Sarah; Naylor, Kari

2012-01-01

Phagocytosis and exocytosis are two cellular processes involving membrane dynamics. While it is easy to understand the purpose of these processes, it can be extremely difficult for students to comprehend the actual mechanisms. As membrane dynamics play a significant role in many cellular processes ranging from cell signaling to cell division to…

On the geometric analysis and adjustment of optical satellite observations. M.S. Thesis

NASA Technical Reports Server (NTRS)

Tsimis, E.

1972-01-01

Satellite geodesy methods were catagorized into three divisions: geometric, dynamic, and mixed. These catagories furnish the basis for distinction between geometric and dynamic satellite geodesy. The dual adjustment, geometric analysis, and Cartesian coodinate determination are examined for two observing stations. Similar illustrations are given when more than two observing stations are used.

A DYNAMIC NONLINEAR MODEL OF OZONE-INDUCED FEV1 RESPONSE UNDER CHANGING EXPOSURE CONDITIONS

EPA Science Inventory

A Dynamic Nonlinear Model of Ozone-induced FEV1 Response under Changing Exposure Conditions. 1WF McDonnell, 2PW Stewart, 3MV Smith. 1Human Studies Division, NHEERL, U.S. EPA, RTP, NC. 2University of North Carolina, Chapel Hill, NC. 3ASI, Durham, NC.

Ozone exposure result...

Experimental unsteady pressures at flutter on the Supercritical Wing Benchmark Model

NASA Technical Reports Server (NTRS)

Dansberry, Bryan E.; Durham, Michael H.; Bennett, Robert M.; Rivera, Jose A.; Silva, Walter A.; Wieseman, Carol D.; Turnock, David L.

1993-01-01

This paper describes selected results from the flutter testing of the Supercritical Wing (SW) model. This model is a rigid semispan wing having a rectangular planform and a supercritical airfoil shape. The model was flutter tested in the Langley Transonic Dynamics Tunnel (TDT) as part of the Benchmark Models Program, a multi-year wind tunnel activity currently being conducted by the Structural Dynamics Division of NASA Langley Research Center. The primary objective of this program is to assist in the development and evaluation of aeroelastic computational fluid dynamics codes. The SW is the second of a series of three similar models which are designed to be flutter tested in the TDT on a flexible mount known as the Pitch and Plunge Apparatus. Data sets acquired with these models, including simultaneous unsteady surface pressures and model response data, are meant to be used for correlation with analytical codes. Presented in this report are experimental flutter boundaries and corresponding steady and unsteady pressure distribution data acquired over two model chords located at the 60 and 95 percent span stations.

Localization of FtsZ in Helicobacter pylori and Consequences for Cell Division

PubMed Central

Specht, Mara; Dempwolff, Felix; Schätzle, Sarah; Thomann, Ralf

2013-01-01

Of the various kinds of cell division, the most common mode is binary fission, the division of a cell into two morphologically identical daughter cells. However, in the case of asymmetric cell division, Caulobacter crescentus produces two morphologically and functionally distinct cell types. Here, we have studied cell cycle progression of the human pathogen Helicobacter pylori using a functional green fluorescent protein (GFP) fusion of FtsZ protein and membrane staining. In small cells, representing newly divided cells, FtsZ localizes to a single cell pole. During the cell cycle, spiral intermediates are formed until an FtsZ ring is positioned with very little precision, such that central as well as acentral rings can be observed. Daughter cells showed considerably different sizes, suggesting that H. pylori divides asymmetrically. Fluorescence recovery after photobleaching (FRAP) analyses demonstrate that the H. pylori FtsZ ring is about as dynamic as that of Escherichia coli but that polar assemblies show less turnover. Strikingly, our results demonstrate that H. pylori cell division follows a different route from that in E. coli and Bacillus subtilis. It is also different from that in C. crescentus, where cytokinesis regulation proteins like MipZ play a role. Therefore, this report provides the first cell-biological analysis of FtsZ dynamics in the human pathogen H. pylori and even in epsilonproteobacteria to our knowledge. In addition, analysis of the filament architecture of H. pylori and E. coli FtsZ filaments in the heterologous system of Drosophila melanogaster S2 Schneider cells revealed that both have different filamentation properties in vivo, suggesting a unique intrinsic characteristic of each protein. PMID:23335414

Divide and shape: an endosymbiont in action.

PubMed

Pyke, Kevin A

2013-02-01

The endosymbiotic evolution of the plastid within the host cell required development of a mechanism for efficient division of the plastid. Whilst a model for the mechanism of chloroplast division has been constructed, little is known of how other types of plastids divide, especially the proplastid, the progenitor of all plastid types in the cell. It has become clear that plastid shape is highly heterogeneous and dynamic, especially stromules. This article considers how such variation in morphology might be controlled and how such plastids might divide efficiently.

Distributed Processing Tools Definition. Volume 1. Hardware and Software Technologies for Tightly-Coupled Distributed Systems.

DTIC Science & Technology

1983-06-01

LOSARDO Project Engineer APPROVED: .MARMCINIhI, Colonel. USAF Chief, Coaud and Control Division FOR THE CCOaIDKR: Acting Chief, Plea Off ice * **711...WORK UNIT NUMBERS General Dynamics Corporation 62702F Data Systems Division P 0 Box 748, Fort Worth TX 76101 55811829 I1. CONTROLLING OFFICE NAME AND...Processing System for 29 the Operation/Direction Center(s) 4-3 Distribution of Processing Control 30 for the Operation/Direction Center(s) 4-4 Generalized

Spire, an actin nucleation factor, regulates cell division during Drosophila heart development.

PubMed

Xu, Peng; Johnson, Tamara L; Stoller-Conrad, Jessica R; Schulz, Robert A

2012-01-01

The Drosophila dorsal vessel is a beneficial model system for studying the regulation of early heart development. Spire (Spir), an actin-nucleation factor, regulates actin dynamics in many developmental processes, such as cell shape determination, intracellular transport, and locomotion. Through protein expression pattern analysis, we demonstrate that the absence of spir function affects cell division in Myocyte enhancer factor 2-, Tinman (Tin)-, Even-skipped- and Seven up (Svp)-positive heart cells. In addition, genetic interaction analysis shows that spir functionally interacts with Dorsocross, tin, and pannier to properly specify the cardiac fate. Furthermore, through visualization of double heterozygous embryos, we determines that spir cooperates with CycA for heart cell specification and division. Finally, when comparing the spir mutant phenotype with that of a CycA mutant, the results suggest that most Svp-positive progenitors in spir mutant embryos cannot undergo full cell division at cell cycle 15, and that Tin-positive progenitors are arrested at cell cycle 16 as double-nucleated cells. We conclude that Spir plays a crucial role in controlling dorsal vessel formation and has a function in cell division during heart tube morphogenesis.

Division of Labor in Biofilms: the Ecology of Cell Differentiation.

PubMed

van Gestel, Jordi; Vlamakis, Hera; Kolter, Roberto

2015-04-01

The dense aggregation of cells on a surface, as seen in biofilms, inevitably results in both environmental and cellular heterogeneity. For example, nutrient gradients can trigger cells to differentiate into various phenotypic states. Not only do cells adapt physiologically to the local environmental conditions, but they also differentiate into cell types that interact with each other. This allows for task differentiation and, hence, the division of labor. In this article, we focus on cell differentiation and the division of labor in three bacterial species: Myxococcus xanthus, Bacillus subtilis, and Pseudomonas aeruginosa. During biofilm formation each of these species differentiates into distinct cell types, in some cases leading to cooperative interactions. The division of labor and the cooperative interactions between cell types are assumed to yield an emergent ecological benefit. Yet in most cases the ecological benefits have yet to be elucidated. A notable exception is M. xanthus, in which cell differentiation within fruiting bodies facilitates the dispersal of spores. We argue that the ecological benefits of the division of labor might best be understood when we consider the dynamic nature of both biofilm formation and degradation.

The National Shipbuilding Research Program: Producibility Cost Reductions through Alternative Materials and Processes

DTIC Science & Technology

1999-03-01

steel; -60F - 250 F; nonflammable acrylic mod- ified methyl - methacrylate Hernon MI React 761; Act 63 two component unprimed steel/primed/ painted trowel... MSD ) of the University of Michigan Transportation Institute (UMTRI), the Shipyards Division of Avondale Industries, and Damilic Corporation, to...classification society requirements. This research was conducted by the research team of the Marine Systems Division ( MSD ) of the University of Michigan

IFLA General Conference, 1989. Division of Education and Research. Section on Education and Training; Round Table on Library History; Round Table on Research in Reading; Round Table on Continuing Professional Education. Booklet 70.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

There are 10 papers in this collection from the Division of Education and Research: (1) "The Importance of Basic Training in Marketing for Librarians and Information Professionals" (French and English versions; Rejean Savard); (2) "Information Management Education: Some Interdisciplinary Approaches" (Marianne Broadbent); (3) "Educational…

The Biological and Chemical Oceanography Data Management Office

NASA Astrophysics Data System (ADS)

Allison, M. D.; Chandler, C. L.; Groman, R. C.; Wiebe, P. H.; Glover, D. M.; Gegg, S. R.

2011-12-01

Oceanography and marine ecosystem research are inherently interdisciplinary fields of study that generate and require access to a wide variety of measurements. In late 2006 the Biological and Chemical Oceanography Sections of the National Science Foundation (NSF) Geosciences Directorate Division of Ocean Sciences (OCE) funded the Biological and Chemical Oceanography Data Management Office (BCO-DMO). In late 2010 additional funding was contributed to support management of research data from the NSF Office of Polar Programs Antarctic Organisms & Ecosystems Program. The BCO-DMO is recognized in the 2011 Division of Ocean Sciences Sample and Data Policy as one of several program specific data offices that support NSF OCE funded researchers. BCO-DMO staff members offer data management support throughout the project life cycle to investigators from large national programs and medium-sized collaborative research projects, as well as researchers from single investigator awards. The office manages and serves all types of oceanographic data and information generated during the research process and contributed by the originating investigators. BCO-DMO has built a data system that includes the legacy data from several large ocean research programs (e.g. United States Joint Global Ocean Flux Study and United States GLOBal Ocean ECosystems Dynamics), to which data have been contributed from recently granted NSF OCE and OPP awards. The BCO-DMO data system can accommodate many different types of data including: in situ and experimental biological, chemical, and physical measurements; modeling results and synthesis data products. The system enables reuse of oceanographic data for new research endeavors, supports synthesis and modeling activities, provides availability of "real data" for K-12 and college level use, and provides decision-support field data for policy-relevant investigations. We will present an overview of the data management system capabilities including: map-based and text-based data discovery and access systems; recent enhancements to data search tools; data export and download utilities; and strategic use of controlled vocabularies to facilitate data integration and to improve data system interoperability.

Whatever Works: A Test of the "Division of Labor" Component of Uses and Gratifications Theory.

ERIC Educational Resources Information Center

Carvalho, John

The 1974 book, "The Uses of Mass Communication: Current Perspectives on Gratifications Research" introduced the concept of a "division of labor"--that certain media work better than others in meeting audience gratifications. Since the division of labor concept has not been subjected to empirical testing, a study elaborated an…

Comparing the Impacts of Tutorial and Edutainment Software Programs on Students' Achievements, Misconceptions, and Attitudes towards Biology

ERIC Educational Resources Information Center

Kara, Yilmaz; Yesilyurt, Selami

2008-01-01

The purpose of this study was to investigate the effects of tutorial and edutainment design of instructional software programs related to the "cell division" topic on student achievements, misconceptions and attitudes. An experimental research design including the cell division achievement test (CAT), the cell division concept test (CCT) and…

Japanese Sex Differences in Preferred & Observed Divisions of Labor in the Home.

ERIC Educational Resources Information Center

Engel, John W.

This research describes sex roles and divisions of labor observed in families of origin by contemporary Japanese (n=1,000) and contemporary preferences for division or sharing of family tasks. It then compares these preferences to determine whether significant differences exist between men and women in contemporary Japan. For their present and…

Dr. von Braun With Management Team

NASA Technical Reports Server (NTRS)

1961-01-01

Dr. von Braun is shown in this photograph, which was probably taken in the early 1960s, with members of his management team. Pictured from left to right are, Werner Kuers, Director of the Manufacturing Engineering Division; Dr. Walter Haeussermarn, Director of the Astrionics Division; Dr. William Mrazek, Propulsion and Vehicle Engineering Division; Dr. von Braun; Dieter Grau, Director of the Quality Assurance Division; Dr. Oswald Lange, Director of the Saturn Systems Office; and Erich Neubert , Associate Deputy Director for Research and Development.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The goals and accomplishments of the Energy Division of Oak Ridge National Laboratory are described in this annual progress report for Fiscal Year (FY) 1988. The Energy Division is a multidisciplinary research organization committed to (1) increasing the knowledge and understanding of the way society makes choices in energy use and energy-using technologies, (2) improving society's understanding of the environmental implications of changes in energy technology, and (3) improving and developing new energy-efficient technologies. The Energy Division's programmatic activities focus on four major areas: (1) analysis and assessment, (2) transportation and decision systems research, (3) technology research and development formore » improving the efficiency of energy and end-use technologies, and (4) electric power systems. The Division's total expenditures in FY 1988 were $44.3 million. The work is supported by the US Department of Energy, US Department of Defense, many other federal agencies, and some private organizations. Disciplines of the 139 staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics.« less

New position at Lamont-Doherty

NASA Astrophysics Data System (ADS)

Three scientists at the Lamont-Doherty Geological Observatory have been appointed to the position of Doherty Senior Research Scientist, newly created to recognize members of the observatory's senior research staff who have demonstrated “the highest levels of scholarship, scientific leadership, and promise of continuing excellence.”William Ruddiman, associate director of the observatory's Oceans and Climate Division, Taro Takahashi, associate director of the Geochemistry Division, and Dennis Kent, known for his research in paleomagnetics and rock magnetism, were each appointed to 5-year terms as Doherty Senior Research Scientists.

Loads and aeroelasticity division research and technology accomplishments for FY 1985 and plans for FY 1986

NASA Technical Reports Server (NTRS)

Gardner, J. E.; Dixon, S. C.

1986-01-01

The Langley Research Center Loads and Aeroelasticity Division's research accomplishments for FY85 and research plans for FY86 are presented. The rk under each branch (technical area) will be described in terms of highlights of accomplishments during the past year and highlights of plans for the current year as they relate to five year plans for each technical area. This information will be useful in program coordination with other government organizations and industry in areas of mutual interest.

IFLA General Conference, 1991. Division of Education and Research: Section of Education and Training; Continuing Professional Education (RT); Section of Library Theory and Research; Library History (RT); Research in Reading (RT); Editors of Library Journals (RT). Booklet 7.

ERIC Educational Resources Information Center

International Federation of Library Associations and Institutions, The Hague (Netherlands).

The 12 papers in this collection were presented at 6 sections of the Division of Education and Research: (1) "Emergence of the Asian Pacific Area and Its Impact on Education and Training of Librarians" (Maxine K. Rochester, Australia); (2) "The Cultural Aspects of Colonialism: Case Study of the Relevance of the Imported Curriculum…

IFLA General Conference, 1992. Division of Education and Research: Editors of Library Journals (RT); Section on Research in Reading; Section on Women's Interest in Librarianship; Section on Education and Training; Continuing Professional Education (RT); Section on Library Theory and Research. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations and Institutions, London (England).

The following 19 papers were delivered at the 1992 annual meeting of the International Federation of Library Associations and Institutions for the Division of Education and Research: (1) "Across the Frontiers: Impact of Foreign Journals in Library Science in India: A Citation Analysis" (M. A. Gopinath); (2) "Children and Reading in…

Identifying and Promoting Transition Evidence-Based Practices and Predictors of Success: A Position Paper of the Division on Career Development and Transition

ERIC Educational Resources Information Center

Mazzotti, Valerie L.; Rowe, Dawn A.; Cameto, Renee; Test, David W.; Morningstar, Mary E.

2013-01-01

This position paper describes the Division of Career Development and Transition's stance and recommendations for identifying and promoting secondary transition evidence-based practices and predictors of postschool success for students with disabilities. Recommendations for experimental research, correlational research, and secondary analysis of…

Foundation laid for understanding essentials of cell division | Center for Cancer Research

Cancer.gov

NCI Center for Cancer Research (CCR) scientists reported new molecular insights into understanding a critical aspect of cell division through a cross-disciplinary effort that combines cryo-electron microscopy (cryo-EM), biochemical and cell biological approaches. Errors in segregation of chromosomes during mitosis can lead to an aberrant number of chromosomes, a condition

Management Auditing

DTIC Science & Technology

1975-09-01

Programs Psychological Sciences Division Office of Naval Research Contract No. N00014-74-A-0436-0001 NR 151-370 Approved for public release...Supported By Commandant of the Marine Corps (Code RD) And Monitored By Personnel and Training Research Programs Psychological Sciences Division...balance 6. Test for effectiveness 7. Search for problems 8. Ascertain solutions 9« Determine alternatives 10. Seek out methods for improvement

The Inverse Relation between Multiplication and Division: Concepts, Procedures, and a Cognitive Framework

ERIC Educational Resources Information Center

Robinson, Katherine M.; LeFevre, Jo-Anne

2012-01-01

Researchers have speculated that children find it more difficult to acquire conceptual understanding of the inverse relation between multiplication and division than that between addition and subtraction. We reviewed research on children and adults' use of shortcut procedures that make use of the inverse relation on two kinds of problems:…

Adaptive Training Considerations for Use in Simulation-Based Systems

DTIC Science & Technology

2010-09-01

their rulings were given and three cases were used for both the pretest and posttest . In the fully adaptive condition, the number of instances...Mercado Anthony J. Aakre KAEGAN Corporation NAVAL AIR WARFARE CENTER TRAINING SYSTEMS DIVISION 12350 Research Parkway Orlando, FL, 32826-3275...Engineering Director, Research & Technology Division Department Special Report 2010-001 2

Scientific Scope | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention conducts and supports research to determine a person's risk of developing cancer and to find ways to reduce that risk. Through laboratory, clinical, and epidemiologic research, scientists have shown that the diseases of cancer occur not as single, catastrophic events, but rather as the result of a complex and long-evolving molecular process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

In 1988 the Atmospheric and Geophysical Sciences Division began its 15th year as a division. As the Division has grown over the years, its modeling capabilities have expanded to include a broad range of time and space scales ranging from hours to years, and from kilometers to global, respectively. For this report, we have chosen to show a subset of results from several projects to illustrate the breadth, depth, and diversity of the modeling activities that are a major part of the Division's research, development, and application efforts. In addition, the recent reorganization of the Division, including the merger ofmore » another group with the Division, is described, and the budget, personnel, models, and publications are reviewed. 95 refs., 26 figs., 2 tabs.« less

Honors

NASA Astrophysics Data System (ADS)

Anonymous

2013-07-01

The Geological Society of America's (GSA) new class of medal and award recipients and fellows includes many AGU members. Medal and award recipients are Stephen G. Pollock, University of Southern Maine: GSA Distinguished Service Award; John R. Wheaton, Montana Bureau of Mines and Geology: John C. Frye Award; Clifford A. Jacobs, National Science Foundation (NSF): Outstanding Contributions Award, Geoinformatics Division; Peter Bird, University of California, Los Angeles (emeritus): George P. Woollard Award, Geophysics Division; Chunmiao Zheng, University of Alabama: O. E. Meinzer Award, Hydrogeology Division; Gerhard Wörner, Georg August Universität Göttingen: Distinguished Geologic Career Award, Mineralogy, Geochemistry, Petrology, and Volcanology Division; Alan D. Howard, University of Virginia: G. K. Gilbert Award, Planetary Geology Division; Michael E. Perkins, University of Utah: Kirk Bryan Award for Research Excellence, Quaternary Geology and Geomorphology Division; and Peter J. Hudleston, University of Minnesota: Career Contribution Award, Structural Geology and Tectonics Division.

A Shortened Stress Measure in Military Nursing Personnel

DTIC Science & Technology

2017-10-17

NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION 59th Clinical Research Division REPORT NUMBER 1100 Willford...ACRONYM(S) 59th Clinical Research Division 1100 Willford Hall Loop, Bldg 4430 JBSA-Lackland, TX 78236-9908 11. SPONSOR/MONITOR’S REPORT 210-292-7141...consent of the subjects used in this research was obtained as required by 32 CFR 2019 and DODI 3216.02 AFI 40-402. SHORTENED STRESS MEASURE WITH

ADP Analysis project for the Human Resources Management Division

NASA Technical Reports Server (NTRS)

Tureman, Robert L., Jr.

1993-01-01

The ADP (Automated Data Processing) Analysis Project was conducted for the Human Resources Management Division (HRMD) of NASA's Langley Research Center. The three major areas of work in the project were computer support, automated inventory analysis, and an ADP study for the Division. The goal of the computer support work was to determine automation needs of Division personnel and help them solve computing problems. The goal of automated inventory analysis was to find a way to analyze installed software and usage on a Macintosh. Finally, the ADP functional systems study for the Division was designed to assess future HRMD needs concerning ADP organization and activities.

Teaching Cell Division to Secondary School Students: An Investigation of Difficulties Experienced by Turkish Teachers

ERIC Educational Resources Information Center

Oztap, Haydar; Ozay, Esra; Oztap, Fulya

2003-01-01

This study examines the difficulties biology teachers face when teaching cell division in the secondary schools of the central part of the Erzurum province in Turkey. During this research, a questionnaire was distributed to a total of 36 secondary school biology teachers. Findings of the study indicate biology teachers perceive cell division as…

A Design Study to Develop Young Children's Understanding of Multiplication and Division

ERIC Educational Resources Information Center

Bicknell, Brenda; Young-Loveridge, Jenny; Nguyen, Nhung

2016-01-01

This design study investigated the use of multiplication and division problems to help 5-year-old children develop an early understanding of multiplication and division. One teacher and her class of 15 5-year-old children were involved in a collaborative partnership with the researchers. The design study was conducted over two 4-week periods in…

Preparing for Exit from Sport: A Phenomenological Examination of the Pre-Transition Experiences of Division I Female Intercollegiate Athletes

ERIC Educational Resources Information Center

Archer, David Eric

2010-01-01

Scope and Method of Study: The purpose of this study was to discover the meanings female intercollegiate athletes ascribe to their experiences preceding exit from NCAA Division I competition. The study sample included five Division I female intercollegiate athletes. Four of these attended a large public research institution in the Southern Plains…

Structures and Acoustics Division

NASA Technical Reports Server (NTRS)

Acquaviva, Cynthia S.

1999-01-01

The Structures and Acoustics Division of NASA Glenn Research Center is an international leader in rotating structures, mechanical components, fatigue and fracture, and structural aeroacoustics. Included are disciplines related to life prediction and reliability, nondestructive evaluation, and mechanical drive systems. Reported are a synopsis of the work and accomplishments reported by the Division during the 1996 calendar year. A bibliography containing 42 citations is provided.

All Tumor Cells Are Not Created Equal | Center for Cancer Research

Cancer.gov

Cell division is commonly thought of as a process whereby one cell gives rise to two identical daughter cells. However, rare cell divisions are asymmetric, generating daughter cells that may differ in size, developmental potential, or even DNA content. The ability of stem cells to undergo asymmetric division allows them to self-renew while simultaneously generate daughter

Cell cycle-regulated PLEIADE/AtMAP65-3 links membrane and microtubule dynamics during plant cytokinesis.

PubMed

Steiner, Alexander; Rybak, Katarzyna; Altmann, Melina; McFarlane, Heather E; Klaeger, Susan; Nguyen, Ngoc; Facher, Eva; Ivakov, Alexander; Wanner, Gerhard; Kuster, Bernhard; Persson, Staffan; Braun, Pascal; Hauser, Marie-Theres; Assaad, Farhah F

2016-11-01

Cytokinesis, the partitioning of the cytoplasm following nuclear division, requires extensive coordination between cell cycle cues, membrane trafficking and microtubule dynamics. Plant cytokinesis occurs within a transient membrane compartment known as the cell plate, to which vesicles are delivered by a plant-specific microtubule array, the phragmoplast. While membrane proteins required for cytokinesis are known, how these are coordinated with microtubule dynamics and regulated by cell cycle cues remains unclear. Here, we document physical and genetic interactions between Transport Protein Particle II (TRAPPII) tethering factors and microtubule-associated proteins of the PLEIADE/AtMAP65 family. These interactions do not specifically affect the recruitment of either TRAPPII or MAP65 proteins to the cell plate or midzone. Rather, and based on single versus double mutant phenotypes, it appears that they are required to coordinate cytokinesis with the nuclear division cycle. As MAP65 family members are known to be targets of cell cycle-regulated kinases, our results provide a conceptual framework for how membrane and microtubule dynamics may be coordinated with each other and with the nuclear cycle during plant cytokinesis. © 2016 The Authors The Plant Journal © 2016 John Wiley & Sons Ltd.

MONTHLY HIGHLIGHTS (SUBSURFACE PROTECTION AND REMEDIATION DIVISION)

EPA Science Inventory

The Subsurface Protection and Remediation Division (SPRD) produces monthly highlights describing research accomplishments, involvement in current technical assistance activities, and staff participation in scientific meetings and conferences. Announcements of the release and avai...

Data Presentation on Transportation Agency Websites: Trends and Best Practices

DOT National Transportation Integrated Search

2017-05-01

The Division of Research, Innovation and System Information (DRISI) within Californias Department of Transportation (Caltrans) provides solutions and knowledge that improves Californias transportation system. The Division recently sought to det...

Coordinated Research in Robotics and Integrated Manufacturing.

DTIC Science & Technology

1983-07-31

of three research divisions: Robot Systems, Management Systems, and Integrated Design and Manufacturing, and involves about 40 faculty spanning the...keystone of their program. A relatively smaller level of effort is being supported within the Management Systems Division. This is the first annual...SYSTEMS MANAGEMENT 0 DESIGN DATABASES " ROBOT-BASED 0 HUMAN FACTORSMANUFACTURING • CAD CELL* PRODUCTIONMUCR LANNING * INTEGRATION LANGUAGE AND VIA LOCAL

National Nutrition Policy: Nutrition and Health; Nutrition and the International Situation; Nutrition and Food Availability, Working Papers.

ERIC Educational Resources Information Center

Quimby, Freeman H.; Chapman, Cynthia B.

This document was compiled by the Specialist, Life Sciences, Science Policy Research Division and the Analyst, Biological Sciences, Science Policy Research Division of the Library of Congress in response to a request of the Senate Select Committee on Nutrition and Human Needs. Submitted under the general title, "A Compilation of Key Papers for Use…

Clinical Characterization of Aerosolized Francisella tularensis Infection in Cynomolgus macaques

DTIC Science & Technology

2016-11-21

2Molecular Toxicology Division, 3Pathology Division U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Maryland...Corresponding author. Address: Center for Aerobiological Sciences, U.S. Army Medical Research Institute of Infectious Diseases , 1425 Porter Street...16-186 DISTRIBUTION STATEMENT A: Approved for public release; distribution is unlimited. UNCLASSIFIED 2 Abstract The disease progression and

The Effects of Ejection Seat Cushion Design on Physical Fatigue and Cognitive Performance

DTIC Science & Technology

2006-11-01

Protection Division Biomechanics Branch Wright-Patterson AFB Ohio 45433-7947 Approved for public release; distribution is unlimited. NOTICE...ADDRESS(ES *Air Force Materiel Command Air Force Research Laboratory Human Effectiveness Directorate Biosciences & Protection Division Biomechanics ...Dayton, Ohio. Analyses of the data were accomplished by the Biomechanics Branch, Human Effectiveness Directorate of the Air Force Research Laboratory

Analytical Tools for Affordability Analysis

DTIC Science & Technology

2015-05-01

function (Womer)  Unit cost as a function of learning and rate  Learning with forgetting (Benkard)  Learning depreciates over time  Discretionary...Analytical Tools for Affordability Analysis David Tate Cost Analysis and Research Division Institute for Defense Analyses Report Documentation...ES) Institute for Defense Analyses, Cost Analysis and Research Division,4850 Mark Center Drive,Alexandria,VA,22311-1882 8. PERFORMING ORGANIZATION

ARC-2009-ACD09-0261-015

NASA Image and Video Library

2009-12-10

Korean High Level Delegation Visit Ames Certer Director and various Senior staff: John Hines, Ames Center Chief Technologist (middel left) explains operations at the LADEE lab to Soon-Duk Bae, Deputy Director, Big Science Policy Division, Ministry of Educaiton, Science Technology, Young-Mok Hyun, Deputy Director, Space Development Division, Ministry of Educaiton, Science Technology, Seorium Lee, Senior Researcher, International Relations Korea Aerospace Research Institute.

Two Outstanding Investigator Awards Go to Division of Cancer Prevention Grantees | Division of Cancer Prevention

Cancer.gov

NCI's Outstanding Investigator Award supports accomplished leaders in cancer research, who are providing significant contributions toward understanding cancer and developing applications that may lead to a breakthrough in biomedical, behavioral, or clinical cancer research. The Award provides up to $600,000 in direct costs per year for 7 years, allowing substantial time for

Shizuko Sei, MD | Division of Cancer Prevention

Cancer.gov

Dr. Shizuko Sei (formerly Shizuko Aoki) is a medical officer with over 27 years of translational and clinical research experience in the field of cancer and AIDS. After completing her pediatric oncology fellowship at NCI Center for Cancer Research (CCR), she held various positions in the CCR and Division of Cancer Treatment and Diagnosis (DCTD) before joining the DCP in July

Ann O'Mara, PhD, RN, MPH | Division of Cancer Prevention

Cancer.gov

Dr. Ann O'Mara is Head of Palliative Research in the NCI Division of Cancer Prevention. She manages a portfolio of symptom management and palliative and end-of-life care research projects. The majority of these projects focus on the more common morbidities associated with cancer and its treatment, e.g., pain, chemotherapy induced neuropathy, fatigue, sleep disturbances, and

2016.11.22 Updated Materials Physics and Applications Division Overview Presentation for TV monitor in 3-1415-Lobby

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duran, Susan M.

These slides are the updated overview presentation for the TV monitor in 3-1415-Lobby at Los Alamos National Laboratory (LANL). It gives an overview of the Materials Physics and Applications Division, including descriptions of the leaders, where researchers are fellows (such as APS or OSA), the newest LANL fellows at MPA, and many other researchers who have won prizes. Finally, MPA's research accomplishments and focuses are detailed.

Modification of Measures of Acute Kidney Injury to Risk Stratify Combat Casualties

DTIC Science & Technology

2017-08-26

AUTHOR(S) Lt Col Jonathan Sosnov 7. PERFORMING ORGANIZATIO,N NAME(S)ANDAODRESS(ES) 59th Clinical Research Division ! JOO \\Villford Hall Loop, Bldg...4430 JBSA-Lackland, TX 78236-9908 210-292-7141 9. SPONSORING/MONITORING AGENCY NAME(S) ANO ADORESS(ES) 59th Clinical Research Division 1100 Will...3218.02_AFI 40-402. Methods Patients: 130 consecutive bum patients admitted to the ICU at the United States Army Institute of Surgical Research

Sustainable production of wood and non-wood forest products: Proceedings of IUFRO Division 5 Research Groups 5.11 and 5.12, Rotorua, New Zealand, March 11–15, 2003.

Treesearch

E.M. Donoghue; G.L. Benson; J.L. Chamberlain

2004-01-01

This proceedings is a collection of 18 papers and extended abstracts based on talks presented at the International Union of Forest Research Organizations (IUFRO) All Division 5 Conference, held in Rotorua, New Zealand, March 11–15, 2003. This conference emphasized the many ways that forest products research can contribute to sustainable choices in forest management....

Using stochastic cell division and death to probe minimal units of cellular replication

NASA Astrophysics Data System (ADS)

Chib, Savita; Das, Suman; Venkatesan, Soumya; Sai Narain Seshasayee, Aswin; Thattai, Mukund

2018-03-01

The invariant cell initiation mass measured in bacterial growth experiments has been interpreted as a minimal unit of cellular replication. Here we argue that the existence of such minimal units induces a coupling between the rates of stochastic cell division and death. To probe this coupling we tracked live and dead cells in Escherichia coli populations treated with a ribosome-targeting antibiotic. We find that the growth exponent from macroscopic cell growth or decay measurements can be represented as the difference of microscopic first-order cell division and death rates. The boundary between cell growth and decay, at which the number of live cells remains constant over time, occurs at the minimal inhibitory concentration (MIC) of the antibiotic. This state appears macroscopically static but is microscopically dynamic: division and death rates exactly cancel at MIC but each is remarkably high, reaching 60% of the antibiotic-free division rate. A stochastic model of cells as collections of minimal replicating units we term ‘widgets’ reproduces both steady-state and transient features of our experiments. Sub-cellular fluctuations of widget numbers stochastically drive each new daughter cell to one of two alternate fates, division or death. First-order division or death rates emerge as eigenvalues of a stationary Markov process, and can be expressed in terms of the widget’s molecular properties. High division and death rates at MIC arise due to low mean and high relative fluctuations of widget number. Isolating cells at the threshold of irreversible death might allow molecular characterization of this minimal replication unit.

Ground Water Technical Support Center (GWTSC) Annual ...

EPA Pesticide Factsheets

The Ground Water Technical Support Center (GWTSC) is part of the Ground Water and Ecosystems Restoration Division (GWERD), which is based in the Robert S. Kerr Environmental Research Center in Ada, Oklahoma. The GWERD is a research division of U.S. EPA’s National Risk Management Research Laboratory (NRMRL). The GWTSC is one of an interlinked group of specialized Technical Support Centersthat were established under the Technical Support Project (TSP). The GWTSC provides technical support on issues related to groundwater. Specifically, the GWTSC provides technical support to U.S. EPA and State regulators for issues and problems related to:1. subsurface contamination (contaminants in ground water, soils and sediments),2. cross-media transfer (movement of contaminants from the subsurface to other media such as surface water or air), and3. restoration of impacted ecosystems.The GWTSC works with Remedial Project Managers (RPMs) and other decision makers to solve specific problems at Superfund, RCRA (Resource Conservation and Recovery Act), Brownfields sites, and ecosystem restoration sites. The Ground Water Technical Support Center (GWTSC) is part of the Ground Water and Ecosystems Restoration Division (GWERD), which is based in the Robert S. Kerr Environmental Research Center in Ada, Oklahoma. The GWERD is a research division of U.S. EPA’s National Risk Management Research Laboratory (NRMRL). The GWTSC is one of an interlinked group of specialized Technical Suppo

Arabidopsis plants perform arithmetic division to prevent starvation at night

PubMed Central

Scialdone, Antonio; Mugford, Sam T; Feike, Doreen; Skeffington, Alastair; Borrill, Philippa; Graf, Alexander; Smith, Alison M; Howard, Martin

2013-01-01

Photosynthetic starch reserves that accumulate in Arabidopsis leaves during the day decrease approximately linearly with time at night to support metabolism and growth. We find that the rate of decrease is adjusted to accommodate variation in the time of onset of darkness and starch content, such that reserves last almost precisely until dawn. Generation of these dynamics therefore requires an arithmetic division computation between the starch content and expected time to dawn. We introduce two novel chemical kinetic models capable of implementing analog arithmetic division. Predictions from the models are successfully tested in plants perturbed by a night-time light period or by mutations in starch degradation pathways. Our experiments indicate which components of the starch degradation apparatus may be important for appropriate arithmetic division. Our results are potentially relevant for any biological system dependent on a food reserve for survival over a predictable time period. DOI: http://dx.doi.org/10.7554/eLife.00669.001 PMID:23805380

Day-night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis.

PubMed

Tulina, Natalia M; Chen, Wen-Feng; Chen, Jung Hsuan; Sowcik, Mallory; Sehgal, Amita

2014-02-25

Adult stem cells maintain tissue integrity and function by renewing cellular content of the organism through regulated mitotic divisions. Previous studies showed that stem cell activity is affected by local, systemic, and environmental cues. Here, we explore a role of environmental day-night cycles in modulating cell cycle progression in populations of adult stem cells. Using a classic stem cell system, the Drosophila spermatogonial stem cell niche, we reveal daily rhythms in division frequencies of germ-line and somatic stem cells that act cooperatively to produce male gametes. We also examine whether behavioral sleep-wake cycles, which are driven by the environmental day-night cycles, regulate stem cell function. We find that flies lacking the sleep-promoting factor Sleepless, which maintains normal sleep in Drosophila, have increased germ-line stem cell (GSC) division rates, and this effect is mediated, in part, through a GABAergic signaling pathway. We suggest that alterations in sleep can influence the daily dynamics of GSC divisions.

CLASSIFICATION FRAMEWORK FOR COASTAL SYSTEMS

EPA Science Inventory

U.S. Environmental Protection Agency. Classification Framework for Coastal Systems. EPA/600/R-04/061. U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, Narragansett, RI, Gulf Ecology Division, Gulf Bree...

32 CFR 776.79 - The complaint.

Code of Federal Regulations, 2010 CFR

2010-07-01

... attached to the complaint. (b) A complaint may be initiated by any person, including the Administrative Law Division of the Office of JAG (JAG (13)), or the Judge Advocate Research and Civil Law Branch, JA Division...

32 CFR 776.79 - The complaint.

Code of Federal Regulations, 2011 CFR

2011-07-01

... attached to the complaint. (b) A complaint may be initiated by any person, including the Administrative Law Division of the Office of JAG (JAG (13)), or the Judge Advocate Research and Civil Law Branch, JA Division...

32 CFR 776.79 - The complaint.

Code of Federal Regulations, 2013 CFR

2013-07-01

... attached to the complaint. (b) A complaint may be initiated by any person, including the Administrative Law Division of the Office of JAG (JAG (13)), or the Judge Advocate Research and Civil Law Branch, JA Division...

32 CFR 776.79 - The complaint.

Code of Federal Regulations, 2014 CFR

2014-07-01

... attached to the complaint. (b) A complaint may be initiated by any person, including the Administrative Law Division of the Office of JAG (JAG (13)), or the Judge Advocate Research and Civil Law Branch, JA Division...

32 CFR 776.79 - The complaint.

Code of Federal Regulations, 2012 CFR

2012-07-01

... attached to the complaint. (b) A complaint may be initiated by any person, including the Administrative Law Division of the Office of JAG (JAG (13)), or the Judge Advocate Research and Civil Law Branch, JA Division...

Achievement of First-, Second-, and Third-Grade Students on Multiplication and Division Word Problems in Two Different Solution Environments.

ERIC Educational Resources Information Center

O'Brien, Aileen; Cabral, Sheryl Ann

This is a project in an emerging line of research investigating children's informed knowledge of mathematics questions. The purpose of this study was to analyze the ability of students who had not received multiplication or division instruction to solve multiplication and division word problems. The study consisted of videotaped interviews with 89…

IFLA General Conference, 1990. Division of Education and Research: Section of Education and Training; Section of Library Theory and Research; Library History, Round Table; Research in Reading, Round Table; Editors of Library Journals, Round Table; and Continuing Professional Education, Round Table; Joint Workshop Papers. Booklet 7.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

The 21 papers in this collection were presented at the meetings of two sections and three round tables of the Division of Education and Research: (1) "Library and Information Services in Culturally Diverse Communities" (Cheryl Metoyer-Duran); (2) "Library Education in a Pluralistic Society" (Shmuel Sever); (3) "Each One an Individual:…

Spotlight on GME/GHSE Supported Research

DTIC Science & Technology

2017-12-07

REPORT TYPE 3. DATES COVERED (From- To) 12/07/2017 Poster 4. TITLE AND SUBTITLE Sa. CONTRACT NUMBER Spotlight on GME/GHSE-Supported Research Sb...Clinical Research Division ., 4t€t.>Jc~"-\\. ~[lJI~IT~&[L IT~W~~UIT@&lYIT©~~ ~~@@~[RJ ~[0@1J[LI1@ 1r (Q)~ @~ An example of a "Parent" 59 MDW/ST R&D Project...ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION 59th Clinical Research Division REPORT NUMBER 1100 Willford Hall Loop, Bldg 4430 JBSA

Summaries of FY 1993 Engineering Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-09-01

This report documents the BES Engineering Research Program for fiscal year 1993; it provides a summary for each of the program projects in addition to a brief program overview. The report is intended to provide staff of Congressional committees, other executive departments, and other DOE offices with substantive program information so as to facilitate governmental overview and coordination of Federal research programs. Of equal importance, its availability facilitates communication of program information to interested research engineers and scientists. The organizational chart for the DOE Office of Energy Research (OER) on the next page delineates the six Divisions within the OERmore » Office of Basic Energy Sciences (BES). Each BES Division administers basic, mission oriented research programs in the area indicated by its title. The BES Engineering Research Program is one such program; it is administered by the Engineering and Geosciences Division of BES. In preparing this report we asked the principal investigators to submit summaries for their projects that were specifically applicable to fiscal year 1993. The summaries received have been edited if necessary.« less

CFD Data Sets on the WWW for Education and Testing

NASA Technical Reports Server (NTRS)

Globus, Al; Lasinski, T. A. (Technical Monitor)

1995-01-01

The Numerical Aerodynamic Simulation (NAS) Systems Division at NASA Ames Research Center has begun the development of a Computational Fluid Dynamics (CFD) data set archive on the World Wide Web (WWW) at URL http://www.nas.nasa.gov/NAS/DataSets/. Data sets are integrated with related information such as research papers, metadata, visualizations, etc. In this paper, four classes of users are identified and discussed: students, visualization developers, CFD practitioners, and management. Bandwidth and security issues are briefly reviewed and the status of the archive as of May 1995 is examined. Routine network distribution of data sets is likely to have profound implications for the conduct of science. The exact nature of these changes is subject to speculation, but the ability for anyone to examine the data, in addition to the investigator's analysis, may well play an important role in the future.

Earth Survey Applications Division. [a bibliography

NASA Technical Reports Server (NTRS)

Carpenter, L. (Editor)

1981-01-01

Accomplishments of research and data analysis conducted to study physical parameters and processes inside the Earth and on the Earth's surface, to define techniques and systems for remotely sensing the processes and measuring the parameters of scientific and applications interest, and the transfer of promising operational applications techniques to the user community of Earth resources monitors, managers, and decision makers are described. Research areas covered include: geobotany, magnetic field modeling, crustal studies, crustal dynamics, sea surface topography, land resources, remote sensing of vegetation and soils, and hydrological sciences. Major accomplishments include: production of global maps of magnetic anomalies using Magsat data; computation of the global mean sea surface using GEOS-3 and Seasat altimetry data; delineation of the effects of topography on the interpretation of remotely-sensed data; application of snowmelt runoff models to water resources management; and mapping of snow depth over wheat growing areas using Nimbus microwave data.

The contribution of the Georges Heights Experimental Radar Antenna to Australian radio astronomy

NASA Astrophysics Data System (ADS)

Orchiston, Wayne; Wendt, Harry

2017-12-01

During the late 1940s and throughout the1950s Australia was one of the world’s foremost astronomical nations owing primarily to the dynamic Radio Astronomy Group within the Commonwealth Scientific and Industrial Organisation’s Division of Radiophysics based in Sydney. The earliest celestial observations were made with former WWII radar antennas and simple Yagi aerials attached to recycled radar receivers, before more sophisticated purpose-built radio telescopes of various types were designed and developed. One of the recycled WWII antennas that was used extensively for pioneering radio astronomical research was an experimental radar antenna that initially was located at the Division’s short-lived Georges Heights Field Station but in 1948 was relocated to the new Potts Hill Field Station in suburban Sydney. In this paper we describe this unique antenna, and discuss the wide-ranging solar, galactic and extragalactic research programs that it was used for.

NASA Earth Science Partnerships - The Role and Value of Commercial and Non-Profit Partnerships with Government in the Earth Sciences

NASA Astrophysics Data System (ADS)

Favors, J.; Cauffman, S.; Ianson, E.; Kaye, J. A.; Friedl, L.; Green, D. S.; Lee, T. J.; Murphy, K. J.; Turner, W.

2017-12-01

NASA's Earth Science Division (ESD) seeks to develop a scientific understanding of the Earth as a dynamic, integrated system of diverse components that interact in complex ways - analogous to the human body. The Division approaches this goal through a coordinated series of satellite and airborne missions, sponsored basic and applied research, and technology development. Integral to this approach are strong collaborations and partnerships with a spectrum of organizations with technical and non-technical expertise. This presentation will focus on a new commercial and non-profit partnership effort being undertaken by ESD to integrate expertise unique to these sectors with expertise at NASA to jointly achieve what neither group could alone. Highlights will include case study examples of joint work with perspectives from both NASA and the partner, building interdisciplinary teams with diverse backgrounds but common goals (e.g., economics and Earth observations for valuing natural capital), partnership successes and challenges in the co-production of science and applications, utilizing partner networks to amplify project outcomes, and how involving partners in defining the project scope drives novel and unique scientific and decision-making questions to arise.

A Location-Based Duplex Scheme for Cost Effective Rural Broadband Connectivity Using IEEE 802.22 Cognitive Radio Based Wireless Regional Area Networks

NASA Astrophysics Data System (ADS)

Kalidoss, R.; Bhagyaveni, M. A.; Vishvaksenan, K. S.

2014-08-01

The search for a method of utilizing the scarce spectrum in an efficient manner is an active area of research in both academic and industrial communities. IEEE 802.22 is a standard for wireless regional area network (WRAN) based on cognitive radio (CR) that operates over underutilized portions of TV bands (54-862 MHz). Time division duplex (TDD)-based WRAN cells have such advantages as dynamic traffic allocation, traffic asymmetry to users and ease of spectrum allocation. However, these cells suffer from severe cross time slot (CTS) interference when the frames of the cells are not synchronized with adjacent WRAN cells. In this paper, we evaluate the location-based duplex (LBD) scheme for eliminating the CTS interference. The proposed LBD system is much more flexible and efficient in providing asymmetric data service and eliminating CTS interference by exploiting the advantages of both TDD and frequency division duplex (FDD) schemes. We also compare the performance of LBD systems with virtual cell concepts. Furthermore, our simulation results reveal that LBD-based systems outperform the virtual cell approach in terms of the low signal-to-interference (SIR) ratio requirement by mitigating the effects of CTS.