Reproducibility of serum IgE, Ara h2 skin prick testing and fraction of exhaled nitric oxide for predicting clinical peanut allergy in children.

PubMed

Percival, Elizabeth; Bhatia, Rani; Preece, Kahn; McElduff, Patrick; McEvoy, Mark; Collison, Adam; Mattes, Joerg

2016-01-01

Ara h2 sIgE serum levels improve the diagnostic accuracy for predicting peanut allergy, but the use of Ara h2 purified protein as a skin prick test (SPT), has not been substantially evaluated. The fraction of exhaled nitric oxide (FeNO) shows promise as a novel biomarker of peanut allergy. Reproducibility of these measures has not been determined. The aim was to assess the accuracy and reproducibility (over a time-period of at least 12 months) of SPT to Ara h2 in comparison with four predictors of clinical peanut allergy (Peanut SPT, Ara h2 specific Immunoglobulin E (sIgE), Peanut sIgE and FeNO). Twenty-seven children were recruited in a follow-up of a prospective cohort of fifty-six children at least 12 months after an open-labelled peanut food challenge. Their repeat assessment involved a questionnaire, SPT to peanut and Ara h2 purified protein, FeNO and sIgE to peanut and Ara h2 measurements. Ara h2 SPT was no worse in accuracy when compared with peanut SPT, FeNO, Ara h2 sIgE and peanut sIgE (AUC 0.908 compared with 0.887, 0.889, 0.935 and 0.804 respectively) for predicting allergic reaction at previous food challenge. SPT for peanut and Ara h2 demonstrated limited reproducibility (ICC = 0.51 and 0.44); while FeNO demonstrated good reproducibility (ICC = 0.73) and sIgE for peanut and Ara h2 were highly reproducible (ICC = 0.81 and 0.85). In this population, Ara h2 SPT was no worse in accuracy when compared with current testing for the evaluation of clinical peanut allergy, but had-like peanut SPT-poor reproducibility. FeNO, peanut sIgE and Ara h2 sIgE were consistently reproducible despite an interval of at least 12 months between the repeated measurements.

Reactivity of triruthenium thiophyne and furyne clusters: competitive S-C and P-C bond cleavage reactions and the generation of highly unsymmetrical alkyne ligands.

PubMed

Uddin, Md Nazim; Begum, Noorjahan; Hassan, Mohammad R; Hogarth, Graeme; Kabir, Shariff E; Miah, Md Arzu; Nordlander, Ebbe; Tocher, Derek A

2008-11-28

The synthesis and reactivity of the thiophyne and furyne clusters [Ru3(CO)7(mu-dppm)(mu3-eta2-C4H2E)(mu-P(C4H3E)2)(mu-H)] (E = S, O) is reported. Addition of P(C4H3E)3 to [Ru3(CO)10(mu-dppm)] (1) at room temperature in the presence of Me3NO gives simple substitution products [Ru3(CO)9(mu-dppm)(P(C4H3E)3)] (E = S, 2; E = O, 3). Mild thermolysis in the presence of further Me3NO affords the thiophyne and furyne complexes [Ru3(CO)7(mu-dppm)(mu3-eta2-C4H2E)(mu-P(C4H3E)2)(mu-H)] (E = S, 4; E = O, 6) resulting from both carbon-hydrogen and carbon-phosphorus bond activation. In each the C4H2E (E = S, O) ligand donates 4-electrons to the cluster and the rings are tilted with respect to the mu-dppm and the phosphido-bridged open triruthenium unit. Heating 4 at 80 degrees C leads to the formation of the ring-opened cluster [Ru3(CO)5(mu-CO)(mu-dppm)(mu3-eta3-SC4H3)(mu-P(C4H3S)2)] (5) resulting from carbon-sulfur bond scission and carbon-hydrogen bond formation and containing a ring-opened mu3-eta3-1-thia-1,3-butadiene ligand. In contrast, a similar thermolysis of 3 affords the phosphinidene cluster [Ru3(CO)7(mu-dppm)(mu3-eta2-C4H2O)(mu3-P(C4H3O))] (7) resulting from a second phosphorus-carbon bond cleavage and (presumably) elimination of furan. Treatment of 4 and 6 with PPh3 affords the simple phosphine-substituted products [Ru3(CO)6(PPh3)(mu-dppm)(mu3-eta2-C4H2E)(mu-P(C4H3E)2)(mu-H)] (E = S, 8; E = O, 9). Both thiophyne and furyne clusters 4 and 6 readily react with hydrogen bromide to give [Ru3(CO)6Br(mu-Br)(mu-dppm)(mu3-eta2-eta1-C4H2E)(mu-P(C4H3E)2)(mu-H)] (E = S, 10; E = O, 11) containing both terminal and bridging bromides. Here the alkynes bind in a highly unsymmetrical manner with one carbon acting as a bridging alkylidene and the second as a terminally bonded Fisher carbene. As far as we are aware, this binding mode has only previously been noted in ynamine complexes or those with metals in different oxidation states. The crystal structures of seven of these new triruthenium clusters have been carried out, allowing a detailed analysis of the relative orientations of coordinated ligands.

Deviatoric Constitutive Relationship for Anisotropic Materials

DTIC Science & Technology

1987-06-01

SEFF = VMISES ICHECK (1) = 0 DEPSBP = 0. CALL XFORM (STR(I),STR(2),STR(3),STR(4),STR(5),STR(6), & SR2 ,SZ2 ,ST2 ,SZT2 ,SRT2 ,SRZ2,-TH) GO TO 310...END I F C c Yield h a s occured: D e t e r m i n e ALF, t h e f r a c t i o n of s t r a i n c t h a t is pre-y ie ld . C I F ( ICHECK ...c e l s e m u s t d e t e r m i n e e l a s t i c f r a c t i o n ( a l f ) (see V a v r i c k , J o h n s o n ) C ICHECK (1) = 1 TERM1 = 0

MATREX Simulation Architecture

DTIC Science & Technology

2008-03-10

r e S u p p o r t M i n e s , C o u n t e r m i n e s U n m a n n e d S y s t e m s L o g...i s t i c s N e t w o r k e d E f f e c t s C o m m a n d & C o n t r o l C o n s i s t e n t & H i g h - R e s M i s s i l e M o d e...l i n g C o n s i s t

Enhanced vector borne disease surveillance of California Culex mosquito populations reveals spatial and species-specific barriers of infection.

DOE Office of Scientific and Technical Information (OSTI.GOV)

VanderNoot, Victoria A.; Curtis, Deanna Joy; Koh, Chung-Yan

Monitor i ng in f ectio n s in v ect o rs su c h as m osquit o es, s a nd fl i es, tsetse fl i es, a nd ticks to i denti f y hu m a n path o gens m a y s e r v e as a n ear l y w arn i ng det e ction system t o dir e ct loc a l g o v er n ment dise a se pr e v en t i v e m easu r e s . Onemore » major hurdle i n de t ection is the abi l i t y to scre e n l arge n u mbers of v e c t ors for h uman patho g ens w i thout t h e u s e of ge n o t y pe - s p ecific m o lecu l ar tec h nique s . N e x t genera t ion s equ e nc i ng (NG S ) pr o v i des a n unbi a sed p latfo r m capab l e of identi f y i ng k n o w n a n d unk n o w n p ath o ge n s circula t ing w i thin a v e ctor p opul a tion, but utili z ing t h is te c h nolo g y i s tim e - con s u ming a n d cos t l y for v ecto r -b o rne disease su r v e illan c e pr o gra m s. T o addr e s s this w e d e v e lop e d cos t -eff e ct i v e Ilumina(r) R NA- S eq l i bra r y p r epara t ion m e thodol o gies i n con j u n ction w i t h an automa t ed c ompu t at i onal a n a l y sis pipel i n e to ch a racter i ze t h e microbial popula t ions c ircula t i n g in Cu l e x m o squit o e s (Cul e x qui n quef a s c iatu s , C ul e x quinq u efasc i atus / pip i ens co m pl e x h y bri d s, and C u l e x ta r salis ) t hroug h out Californ i a. W e assembled 2 0 n o vel a n d w e l l -do c ume n ted a r b o v i ruses repres e nting mem b e rs of B u n y a v ir i da e , F l a v i virid a e, If a virida e , Meson i v i rida e , Nid o v iri d ae, O rtho m y x o virid a e, Pa r v o v iri d ae, Re o virid a e, R h a b d o v i rid a e, T y m o v iri d ae, a s w ell as s e v e r al u n assi g n e d v irus e s . In addit i o n, w e m app e d mRNA s pecies to d i vergent s peci e s of t r y panos o ma a nd pl a s modium eu k a r yotic parasit e s and cha r a c terized t he p r oka r yot i c microb i al c o mposit i on to i d enti f y bacteri a l tran s c r ipts der i v ed from wolba c hia, clo s tridi u m, m y c oplas m a, fusoba c terium and c am p y l o bacter bac t er i al spec i e s . W e utilized the s e mic r obial transcri p tomes pre s e nt in g e ogra p hical l y defined Cul e x po p ul a tions to defi n e spatial and m osqui t o specie s -spec i fic ba r r iers of i n fecti o n. T he v i r ome and microbi o me c o mpos i tion id e ntified in e ach mosqui t o p o ol pr o v i ded suf f icient resolut i on to dete r m i ne both the mosq u ito species and the g e o graphic regi o n in Californ i a w h e re t h e mosqui t o po o l orig i n ated. T his d a ta pr o v i des ins i ght in t o the compl e x i t y of microb i al spec i es cir c ulati n g in med i cal l y i mport a nt Culex mosqui t oes a nd t h eir potent i al im p act o n t he tran s missi o n of v ector-b o rne human / veter i na r y p a t hogens in C a liforn i a.« less

Dual Functional Core-Shell Fluorescent Ag2S@Carbon Nanostructure for Selective Assay of E. coli O157:H7 and Bactericidal Treatment.

PubMed

Wang, Ning; Wei, Xing; Zheng, An-Qi; Yang, Ting; Chen, Ming-Li; Wang, Jian-Hua

2017-03-24

A dual functional fluorescent core-shell Ag 2 S@Carbon nanostructure is prepared by a hydrothermally assisted multi-amino synthesis approach with folic acid (FA), polyethylenimine (PEI), and mannoses (Mans) as carbon and nitrogen sources (FA-PEI-Mans-Ag 2 S nanocomposite shortly as Ag 2 S@C). The nanostructure exhibits strong fluorescent emission at λ ex /λ em = 340/450 nm with a quantum yield of 12.57 ± 0.52%. Ag 2 S@C is bound to E. coli O157:H7 via strong interaction with the Mans moiety in Ag 2 S@C with FimH proteins on the fimbriae tip in E. coli O157:H7. Fluorescence emission from Ag 2 S@C/E. coli conjugate is closely related to the content of E. coli O157:H7. Thus, a novel procedure for fluorescence assay of E. coli O157:H7 is developed, offering a detection limit of 330 cfu mL -1 . Meanwhile, the Ag 2 S@C nanostructure exhibits excellent antibacterial performance against E. coli O157:H7. A 99.9% sterilization rate can be readily achieved for E. coli O157:H7 at a concentration of 10 6 -10 7 cfu mL -1 with 3.3 or 10 μg mL -1 of Ag 2 S@C with an interaction time of 5 or 0.5 min, respectively.

Sickle Cell Hemoglobin with Mutation at αHis-50 Has Improved Solubility.

PubMed

Tam, Ming F; Tam, Tsuey Chyi S; Simplaceanu, Virgil; Ho, Nancy T; Zou, Ming; Ho, Chien

2015-08-28

The unliganded tetrameric Hb S has axial and lateral contacts with neighbors and can polymerize in solution. Novel recombinants of Hb S with single amino acid substitutions at the putative axial (recombinant Hb (rHb) (βE6V/αH20R) and rHb (βE6V/αH20Q)) or lateral (rHb (βE6V/αH50Q)) or double amino acid substitutions at both the putative axial and lateral (rHb (βE6V/αH20R/αH50Q) and rHb (βE6V/αH20Q/αH50Q)) contact sites were expressed in Escherichia coli and purified for structural and functional studies. The (1)H NMR spectra of the CO and deoxy forms of these mutants indicate that substitutions at either αHis-20 or αHis-50 do not change the subunit interfaces or the heme pockets of the proteins. The double mutants show only slight structural alteration in the β-heme pockets. All mutants have similar cooperativity (n50), alkaline Bohr effect, and autoxidation rate as Hb S. The oxygen binding affinity (P50) of the single mutants is comparable with that of Hb S. The double mutants bind oxygen with slightly higher affinity than Hb S under the acidic conditions. In high salt, rHb (βE6V/αH20R) is the only mutant that has a shorter delay time of polymerization and forms polymers more readily than Hb S with a dextran-Csat value of 1.86 ± 0.20 g/dl. Hb S, rHb (βE6V/αH20Q), rHb (βE6V/αH50Q), rHb (βE6V/αH20R/αH50Q), and rHb (βE6V/αH20Q/αH50Q) have dextran-Csat values of 2.95 ± 0.10, 3.04 ± 0.17, 11.78 ± 0.59, 7.11 ± 0.66, and 10.89 ± 0.83 g/dl, respectively. rHb (βE6V/αH20Q/αH50Q) is even more stable than Hb S under elevated temperature (60 °C). © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

An Experimental Investigation of Techniques to Suppress Edgetones from Perforated Wind Tunnel Walls

DTIC Science & Technology

1975-08-01

s e e m i t t e d by the p e r f o r a t e d wa l l s h a s b e e n u n d e r s t udy f o r s e v e r a l y e a r s at AEDC. A r e c e...ld at low supe r son i c speeds . Actual s amples of pe r fo ra t ed walls f r o m the t h ree t r a n s o n i c tunnels were t es ted...c t i o n flow and wal l angle that gave a r e a s o n a b l y f la t axia l Mach n u m b e r d i s t r i b u t i o n t h roughou t the

Phase 1 Environmental Baseline Survey for Leasing Nellis Air Force Base Land for Construction and Maintenance of a Stormwater Detention System and Relocation of Military Family Housing Clark County, Nevada

DTIC Science & Technology

2006-11-01

31138 - 65 -5Case Number: Not reportedPhone Number 3: (702)254-0031 HPhone...3000 WPhone Number 1: DAVIS,JEFFContact Name: 1,274.00Facility Rec#: BORAL HCChemical Name: 600 GALQuantity: 31138 - 65 -5Case Number: Not reportedPhone...E G A S S 10 65 14 38 6 R O Y A L E X P R E S S , I N C . IN T E R S T A T E 1 5 @ U .S . H IG H W A Y 9 S H W S LA S V E G A S S 10 58 05 49

PLA Naval Aviation Training and Operations

DTIC Science & Technology

2017-12-20

cr aft Ty p es,” Re n mi n H aij u n , 1 6 A pril 2 0 1 3, p. 3. 3 3 I bi d. 3 4 K o u Yo n g qi a n g, Li Yi mi n, a n d Li X u ef e n g, “ Ta k e...6 a e 4 d 0 d 6 c 1.s ht ml. C h e n Z h e, Z h u Weij u n, a n d Z h u Ya, “ Yo u n g Offi c ers a n d E nlist e d Pers o n n el i n a N ort h S e a...ct o b er 2 0 1 4 , p. 3. MI S SI O N S, O R G A NI Z A TI O N A L S T R U C T U R E, A N D T R AI NI N G ( 2 0 1 3- 1 5) 8 5 K o u Yo n g qi a n g

H.E.S.S. and ATOM detection of renewed activity of the FSRQ 3C 279

NASA Astrophysics Data System (ADS)

De Naurois, Mathieu

2018-06-01

H.E.S.S. observations at very-high energies (E > 100 GeV) of the flat spectrum radio quasar 3C 279 (reshift z=0.536, R.A.: 12h56m11.1665s, Dec: -05d47m21.523s (J2000)) have been carried out over the last 3 nights on the basis of another strong flare in the high-energy gamma-ray band (E > 100 MeV) detected with Fermi-LAT.

UNIVERSALITY OF THE NEAR-INFRARED EXTINCTION LAW BASED ON THE APOGEE SURVEY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Shu; Jiang, B. W., E-mail: shuwang@mail.bnu.edu.cn, E-mail: bjiang@bnu.edu.cn

Whether the near-infrared (NIR) extinction law is universal has long been a debated topic. Based on the APOGEE H-band spectroscopic survey, a key project of SDSS-III, the intrinsic colors of a large number of giant stars are accurately determined from the stellar effective temperature. Taking advantage of this and using a sample of 5942 K-type giants, the NIR extinction law is carefully revisited. The color excess ratio E(J – H)/E(J – K {sub S}), representative of the NIR extinction law, shows no dependence on the color excess when E(J – K {sub S}) changes from ∼0.3 to ∼4.0, which implies amore » universal NIR extinction law from diffuse to dense regions. The constant value of E(J – H)/E(J – K {sub S}), 0.64, corresponds to a power law index of 1.95. The other two ratios, E(H – K {sub S})/E(J – K {sub S}) and E(J – H)/E(H – K {sub S}), are 0.36 and 1.78, respectively. The results are consistent with the MRN dust size distribution.« less

History of the Chaparral/FAAR Air Defense System

DTIC Science & Technology

1977-05-31

i s t ed of t h e AN/DAW-1 guidance s e c t i o n ; t h e M817 t a r g e t d e t e c t i o n device (DIDO f u z e ) ; t h e M250 b l a s t...19n, 21-22, 25, 25n, 27-28, 30-32, 51, 88-89, 107-109, 175 Warhead Blast Fragmentation (BF), 92, 118 M250 (XM-250), 116, 119 continuous rod, 12

VizieR Online Data Catalog: Vela Junior (RX J0852.0-4622) HESS image (HESS+, 2018)

NASA Astrophysics Data System (ADS)

H. E. S. S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Andersson, T.; Anguener, E. O.; Arakawa, M.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Becker Tjus, J.; Berge, D.; Bernhard, S.; Bernloehr, K.; Blackwell, R.; Boettcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Buechele, M.; Bulik, T.; Capasso, M.; Carr, J.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chalme-Calvet, R.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Chretien, M.; Coffaro, M.; Colafrancesco, S.; Cologna, G.; Condon, B.; Conrad, J.; Cui, Y.; Davids, I. D.; Decock, J.; Degrange, B.; Deil, C.; Devin, J.; Dewilt, P.; Dirson, L.; Djannati-Atai, A.; Domainko, W.; Donath, A.; Drury, L. O'c.; Dutson, K.; Dyks, J.; Edwards, T.; Egberts, K.; Eger, P.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Foerster, A.; Funk, S.; Fuessling, M.; Gabici, S.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Gottschall, D.; Goyal, A.; Grondin, M.-H.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holler, M.; Horns, D.; Ivascenko, A.; Iwasaki, H.; Jacholkowska, A.; Jamrozy, M.; Janiak, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jogler, T.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzynski, K.; Katsuragawa, M.; Katz, U.; Kerszberg, D.; Khangulyan, D.; Khelifi, B.; Kieffer, M.; King, J.; Klepser, S.; Klochkov, D.; Kluzniak, W.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Kraus, M.; Krueger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lefranc, V.; Lemiere, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; Lopez-Coto, R.; Lypova, I.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Mora, K.; Moulin, E.; Murach, T.; Nakashima, S.; de Naurois, M.; Niederwanger, F.; Niemiec J.; Oakes, L.; O'Brien, P.; Odaka, H.; Oettl, S.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poon, H.; Prokhorov, D.; Prokoph, H.; Puehlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Reimer, A.; Reimer, O.; Renaud, M.; de Los Reyes, R.; Richter, S.; Rieger, F.; Romoli, C.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Saito, S.; Salek, D.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schuessler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Simoni, R.; Sol, H.; Spanier, F.; Spengler, G.; Spies, F.; Stawarz, L.; Steenkamp, R.; Stegmann, C.; Stycz, K.; Sushch, I.; Takahashi, T.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tsuji, N.; Tuffs, R.; Uchiyama, Y.; van der, Walt D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Voelk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Woernlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zaborov, D.; Zacharias, M.; Zanin, R.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Zywucka, N.

2018-03-01

skymap.fit: H.E.S.S. excess skymap in FITS format of the region comprising Vela Junior and its surroundings. The excess map has been corrected for the gradient of exposure and smoothed with a Gaussian function of width 0.08° to match the analysis point spread function, matching the procedure applied to derive the maps in Fig. 1. sp_stat.txt: H.E.S.S. spectral points and fit parameters for Vela Junior (H.E.S.S. data points in Fig. 3 and Tab. A.2 and H.E.S.S. spectral fit parameters in Tab. 4). The errors in this file represent statistical uncertainties at 1 sigma confidence level. The covariance matrix of the fit is also included in the format: c11 c12 c_13 c21 c22 c_23 c31 c32 c_33 where the subindices represent the following parameters of the power-law with exponential cut-off (ECPL) formula in Tab. 2: 1: flux normalization (Phi0) 2: spectral index (Gamma) 3: inverse of the cutoff energy (lambda=1/Ecut) The units for the covariance matrix are the same as for the fit parameters. Notice that, while the fit parameters section of the file shows E_cut as parameter, the fit was done in lambda=1/Ecut; hence the covariance matrix shows the values for lambda in TeV-1. sp_syst.txt: H.E.S.S. spectral points and fit parameters for Vela Junior (H.E.S.S. data points in Fig. 3 and Tab. A.2 and H.E.S.S. spectral fit parameters in Tab. 4). The errors in this file represent systematic uncertainties at 1 sigma confidence level. The integral fluxes for several energy ranges are also included. (4 data files).

Assessment of Accelerated Acquisition of Defense Programs

DTIC Science & Technology

2016-09-01

I N S T I T U T E F O R D E F E N S E A N A L Y S E S Assessment of Accelerated Acquisition of Defense Programs Richard H. Van Atta R. Royce...Defense for Acquisition . The views, opinions, and findings should not be construed as representing the official position of either the Department of...S T I T U T E F O R D E F E N S E A N A L Y S E S IDA Paper P-8161 Assessment of Accelerated Acquisition of Defense Programs Richard H. Van Atta

Molecular characterization of Echinococcus granulosus isolates from Bulgarian human cystic echinococcosis patients.

PubMed

Marinova, Irina; Spiliotis, Markus; Wang, Junhua; Muhtarov, Marin; Chaligiannis, Ilias; Sotiraki, Smaro; Rainova, Iskra; Gottstein, Bruno; Boubaker, Ghalia

2017-03-01

Although cystic echinococcosis (CE) is highly endemic in Bulgaria, there is still scarce information about species and/or genotypes of the Echinococcus granulosus complex that infect humans. Our study tackled the genetic diversity of E. granulosus complex in a cohort of 30 Bulgarian CE patients. Ten animal E. granulosus isolates from neighboring Greece were additionally included. Specimens were comparatively analyzed for partial sequences of five mitochondrial (mt) (cox I, nad I, rrnS, rrnL, and atp6) and three nuclear (nc) genes (act II, hbx 2, and ef-1α) using a PCR-sequencing approach. All 30 Bulgarian isolates were identified as E. granulosus sensu stricto (s.s.) and were showing identical sequences for each of the three examined partial nc gene markers. Based upon concatenated sequences from partial mtDNA markers, we detected 10 haplotypes: 6 haplotypes (H1-H6) clustering with E. granulosus s.s. (G1) and 4 haplotypes (H9-H13) grouping with E. granulosus s.s. (G3), with H1 and H10 being the most frequent in Bulgarian patients. The haplotypes H1, H4, and H11 were also present in Greek hydatid cyst samples of animal origin. In conclusion, E. granulosus s.s. (G1 and G3 genotypes) is the only causative agent found so far to cause human CE in Bulgaria. However, further studies including larger sample sizes and other additional geographic regions in Bulgaria will have to be performed to confirm our results.

AWARE Wide Field View

DTIC Science & Technology

2016-04-29

G. Anderson, S. D. Feller, E . M. Vera , H. S. Son, S.-H. Youn, J. Kim, M. E . Gehm, D. J. Brady, J. M. Nichols, K. P. Judd, M. D. Duncan, J. R...scale in monocentric gigapixel cameras." Applied Optics 50(30): 5824-5833. Tremblay, E . J., et al. (2012). "Design and scaling of monocentric...cameras. Optomechanical Engineering 2013. A. E . Hatheway. 8836. Youn, S. H., et al. (2013). Efficient testing methodologies for microcameras in a

A Method of Characteristics Computer Program for Three-Dimensional Supersonic Internal Flows

DTIC Science & Technology

1979-01-01

t s a r e i n good a g r e e m e n t w i t h t h e r e s u l t s f r o m a w e l l - e s t a b l i s h e d c o m p u t e r p r o g r a m...of the Lockheed axlsymmetrlc MOC computer program (Ref. 6) which Is well verified and widely used. The results from the two programs are in good ...F ( INE IGHoEOe 2) RETURN 99 CON’f |NUE VlR[ TE( 61 7) STOP END CALL RNEXG CALL REAONE 54 AEDC-TR-78-68 21 SUSROUTI NE NEIGH

Forward and Inverse Modeling of Near-Field Seismic Waveforms from Underground Nuclear Explosions for Effective Source Functions and Structure Parameters.

DTIC Science & Technology

1987-04-05

IP o , I-S " M4.7 :" * AMIWILTON & U, .-- EALY(I969) : o H CARROLL(1966) HADLEY (19811 C . Figure 2. P and S-wave velocity structure for Pahute Mesa...8217; 0 .02 s wh ilIe S -. cI by C ) >, s) thIe kta i Is o f t he wav e for:7s are quite well modeled bot h ir tr~~e inversion nd in tefrad mod e Iin~ indi...ESTIMATION 7-Te source parameters determined through waveform inversion for the fo: s o r c ri i c e h v h s~ ahute Mesa events studied are sum.:rarited in

Service Members in School: Military Veterans’ Experiences Using the Post-9/11 GI Bill and Pursuing Postsecondary Education

DTIC Science & Technology

2010-11-01

for Education, for the American Council on Education S E R V I C E M E M B E R S I N S C H O O L Military Veterans’ Experiences Using the Post...69 Appendix E : Focus Group Demographic Information Sheet . . . . . . . . . . . . . . 71 Appendix F: Interview Protocol for Non...Student Survey . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77 S E R V I C E M E M B E R S I N S C H O O L i i i C

Development of Nanoplatelet Composites

DTIC Science & Technology

2008-12-08

Graphite Intercalation Compounds and Applications, Oxford University Press, 2003. 27 S. Stankovich, D.A. Dikin , D.H.B. Dommett, K.H. Kohlhaas, E.J...Chemistry C 111,7565(2007). 30 S. Stankovich, D.A. Dikin , G.H.B. Dommett, K.M. Kolhaas, E.J. Zimney, E.A. Stach, R.D. Piner, S.T. Ngyuen, and R.A. Ruoff

Systems Engineering Measurement Primer

DTIC Science & Technology

1998-03-01

Schermerhorn , R ., “Determining metrics for...maintenance process. 12 S e l e c t a n d S p e c i f y M e a s u r e s a n d I n d i c a t o r s C o l l e c t D a t a C a l c u l a t e I n d i c a...t o r s A n a l y z e t h e M e a s u r e s o r I n d i c a t o r s R e p o r t a n d U s e t h e R e s u l t s Issues Goals Risks A

Sensitivity Analysis of Empirical Parameters in the Ionosphere-Plasmasphere Model

DTIC Science & Technology

2011-03-01

IFM output grid (Gardner , 2010). The longitudes have to be fit as well because the IPM flux tubes form a type of ‘ S ...n d 2 0 d a y ru n , a n d th e ri g h t p lo t is th e d iff e re n c e . A ft e r d a y fi v e , th e m o d e l o u tp u t h a s re a ch e d st e a ...lo c a ti o n s * . T h

Genomic Characterization of KIR2DL4 in Families and Unrelated Individuals Reveals Extensive Diversity in Exon and Intron Sequences Including a Common Frameshift Variation Occurring in Several Alleles

DTIC Science & Technology

2005-01-18

r A L 1 3 3 4 1 4 ) w a s u s e d a s a re fe re n c e . D a s h e s in d ic a te id e n ti...le d th e tr a n s m e m b ra n e e xo n a s e xo n 7 in o rd e r to k e e p th e re la ti o n s h ip a m o n g K IR e xo n s in th e d if fe re n t...g e n e s c o n s is te n t. N u c le o ti d e p o s it io n s w e

Phylogenetic analysis of Haemaphysalis erinacei Pavesi, 1884 (Acari: Ixodidae) from China, Turkey, Italy and Romania.

PubMed

Hornok, Sándor; Wang, Yuanzhi; Otranto, Domenico; Keskin, Adem; Lia, Riccardo Paolo; Kontschán, Jenő; Takács, Nóra; Farkas, Róbert; Sándor, Attila D

2016-12-15

Haemaphysalis erinacei is one of the few ixodid tick species for which valid names of subspecies exist. Despite their disputed taxonomic status in the literature, these subspecies have not yet been compared with molecular methods. The aim of the present study was to investigate the phylogenetic relationships of H. erinacei subspecies, in the context of the first finding of this tick species in Romania. After morphological identification, DNA was extracted from five adults of H. e. taurica (from Romania and Turkey), four adults of H. e. erinacei (from Italy) and 17 adults of H. e. turanica (from China). From these samples fragments of the cytochrome c oxidase subunit 1 (cox1) and 16S rRNA genes were amplified via PCR and sequenced. Results showed that cox1 and 16S rRNA gene sequence divergences between H. e. taurica from Romania and H. e. erinacei from Italy were below 2%. However, the sequence divergences between H. e. taurica from Romania and H. e. turanica from China were high (up to 7.3% difference for the 16S rRNA gene), exceeding the reported level of sequence divergence between closely related tick species. At the same time, two adults of H. e. taurica from Turkey had higher 16S rRNA gene similarity to H. e. turanica from China (up to 97.5%) than to H. e. taurica from Romania (96.3%), but phylogenetically clustered more closely to H. e. taurica than to H. e. turanica. This is the first finding of H. erinacei in Romania, and the first (although preliminary) phylogenetic comparison of H. erinacei subspecies. Phylogenetic analyses did not support that the three H. erinacei subspecies evaluated here are of equal taxonomic rank, because the genetic divergence between H. e. turanica from China and H. e. taurica from Romania exceeded the usual level of sequence divergence between closely related tick species, suggesting that they might represent different species. Therefore, the taxonomic status of the subspecies of H. erinacei needs to be revised based on a larger number of specimens collected throughout its geographical range.

Exploring the Integration of COSYSMO with a Model-Based Systems Engineering Methodology in Early Trade Space Analytics and Decisions

DTIC Science & Technology

2016-06-01

UAV system but had a larger scope. The publishing timeline for the second UAV model and this thesis ...r l o g i c a l ) t h a t can be used t o d e s c r i b e a p a r t o f t h e model . < / d e s c r i p t i o n > 7 <h idden> f a l s e < / h idden...July). Program manager e -tool kit: Hierarchy of models and simulations . [Online]. Available: https://acc.dau.mil/CommunityBrowser.aspx?id= 294530

A Trapped Mercury 199 Ion Frequency Standard

DTIC Science & Technology

1981-12-01

ing resul t t h a t could possibly be explained by a for tu i t ious cancel la t ion of t w o e f f ec t s : t h e second order doppler...h a t t h e helium cooling is e f f ec t ive . O the r e f f e c t s of t he helium include nar rower l ines and a la rger s ignal indicat...Desaintfuscien, K. Barjllet, J . Viennet, P. Pet i t , and C. Audoin, Appl. Phys. 24, 107 (1981). 4. R, Ifflaender and G. Werth; Metrologia 13, 167 (1977

A Population Pharmacokinetic Modeling Approach Shows that Serum Penicillin G Concentrations Are Below Inhibitory Concentrations by Two Weeks after Benzathine Penicillin G Injection in the Majority of Young Adults

DTIC Science & Technology

2014-11-01

H , El-Kholy AG, Madkour AA, Kaplan EL. 1996. Rheumatic fever prophylaxis using benzathine...by N A V A L H E A LT H R E S E A R C H C T R http://aac.asm .org/ D ow nloaded from received in the study. On day 1, which was sample 1, we...2015 by N A V A L H E A LT H R E S E A R C H C T R http://aac.asm .org/ D ow nloaded from mean of 0.006 g/ml for the other subjects.

Developing Treatment, Treatment Validation, and Treatment Scope in the Setting of an Autism Clinical Trial

DTIC Science & Technology

2013-06-01

neurodevelopmental disorders 3(2): 132-143. Buyske, S., T. A. Williams, A. E. Mars, E. S. Stenroos, S. X. Ming, R. Wang, M. Sreenath, M. F. Factura , C. Reddy, G. H...Gastroenterol Nutr. Williams, T. A., A. E. Mars, S. G. Buyske, E. S. Stenroos, R. Wang, M. F. Factura -Santiago, G. H. Lambert and W. G. Johnson (2007

Joint Force Quarterly. Number 21, Spring 1999

DTIC Science & Technology

1999-03-01

T H E J O I N T W O R L D 113 Doctrine ■ O F F T H E S H E L F 115 Mahan’s Blindness and Brilliance: A Review Essay...er ) U . S . A ir Fo rc e (J oe B el a) 2d M ar in e D iv is io n, C om ba t C am er a (J ac ob A . F ul le r) Marines in Norway for Battle...98. 2d M ar in e D iv is

H.E.S.S. Limits on Linelike Dark Matter Signatures in the 100 GeV to 2 TeV Energy Range Close to the Galactic Center.

PubMed

Abdalla, H; Abramowski, A; Aharonian, F; Ait Benkhali, F; Akhperjanian, A G; Andersson, T; Angüner, E O; Arrieta, M; Aubert, P; Backes, M; Balzer, A; Barnard, M; Becherini, Y; Becker Tjus, J; Berge, D; Bernhard, S; Bernlöhr, K; Birsin, E; Blackwell, R; Böttcher, M; Boisson, C; Bolmont, J; Bordas, P; Bregeon, J; Brun, F; Brun, P; Bryan, M; Bulik, T; Capasso, M; Carr, J; Casanova, S; Chakraborty, N; Chalme-Calvet, R; Chaves, R C G; Chen, A; Chevalier, J; Chrétien, M; Colafrancesco, S; Cologna, G; Condon, B; Conrad, J; Couturier, C; Cui, Y; Davids, I D; Degrange, B; Deil, C; Devin, J; deWilt, P; Djannati-Ataï, A; Domainko, W; Donath, A; Drury, L O'C; Dubus, G; Dutson, K; Dyks, J; Dyrda, M; Edwards, T; Egberts, K; Eger, P; Ernenwein, J-P; Eschbach, S; Farnier, C; Fegan, S; Fernandes, M V; Fiasson, A; Fontaine, G; Förster, A; Funk, S; Füßling, M; Gabici, S; Gajdus, M; Gallant, Y A; Garrigoux, T; Giavitto, G; Giebels, B; Glicenstein, J F; Gottschall, D; Goyal, A; Grondin, M-H; Grudzińska, M; Hadasch, D; Hahn, J; Hawkes, J; Heinzelmann, G; Henri, G; Hermann, G; Hervet, O; Hillert, A; Hinton, J A; Hofmann, W; Hoischen, C; Holler, M; Horns, D; Ivascenko, A; Jacholkowska, A; Jamrozy, M; Janiak, M; Jankowsky, D; Jankowsky, F; Jingo, M; Jogler, T; Jouvin, L; Jung-Richardt, I; Kastendieck, M A; Katarzyński, K; Katz, U; Kerszberg, D; Khélifi, B; Kieffer, M; King, J; Klepser, S; Klochkov, D; Kluźniak, W; Kolitzus, D; Komin, Nu; Kosack, K; Krakau, S; Kraus, M; Krayzel, F; Krüger, P P; Laffon, H; Lamanna, G; Lau, J; Lees, J-P; Lefaucheur, J; Lefranc, V; Lemière, A; Lemoine-Goumard, M; Lenain, J-P; Leser, E; Liu, R; Lohse, T; Lorentz, M; Lypova, I; Marandon, V; Marcowith, A; Mariaud, C; Marx, R; Maurin, G; Maxted, N; Mayer, M; Meintjes, P J; Meyer, M; Mitchell, A M W; Moderski, R; Mohamed, M; Morå, K; Moulin, E; Murach, T; de Naurois, M; Niederwanger, F; Niemiec, J; Oakes, L; O'Brien, P; Odaka, H; Ohm, S; Ostrowski, M; Öttl, S; Oya, I; Padovani, M; Panter, M; Parsons, R D; Paz Arribas, M; Pekeur, N W; Pelletier, G; Perennes, C; Petrucci, P-O; Peyaud, B; Pita, S; Poon, H; Prokhorov, D; Prokoph, H; Pühlhofer, G; Punch, M; Quirrenbach, A; Raab, S; Reimer, A; Reimer, O; Renaud, M; de Los Reyes, R; Rieger, F; Romoli, C; Rosier-Lees, S; Rowell, G; Rudak, B; Rulten, C B; Sahakian, V; Salek, D; Sanchez, D A; Santangelo, A; Sasaki, M; Schlickeiser, R; Schüssler, F; Schulz, A; Schwanke, U; Schwemmer, S; Settimo, M; Seyffert, A S; Shafi, N; Shilon, I; Simoni, R; Sol, H; Spanier, F; Spengler, G; Spies, F; Stawarz, Ł; Steenkamp, R; Stegmann, C; Stinzing, F; Stycz, K; Sushch, I; Tavernet, J-P; Tavernier, T; Taylor, A M; Terrier, R; Tibaldo, L; Tluczykont, M; Trichard, C; Tuffs, R; van der Walt, J; van Eldik, C; van Soelen, B; Vasileiadis, G; Veh, J; Venter, C; Viana, A; Vincent, P; Vink, J; Voisin, F; Völk, H J; Vuillaume, T; Wadiasingh, Z; Wagner, S J; Wagner, P; Wagner, R M; White, R; Wierzcholska, A; Willmann, P; Wörnlein, A; Wouters, D; Yang, R; Zabalza, V; Zaborov, D; Zacharias, M; Zdziarski, A A; Zech, A; Zefi, F; Ziegler, A; Żywucka, N

2016-10-07

A search for dark matter linelike signals iss performed in the vicinity of the Galactic Center by the H.E.S.S. experiment on observational data taken in 2014. An unbinned likelihood analysis iss developed to improve the sensitivity to linelike signals. The upgraded analysis along with newer data extend the energy coverage of the previous measurement down to 100 GeV. The 18 h of data collected with the H.E.S.S. array allow one to rule out at 95% C.L. the presence of a 130 GeV line (at l=-1.5°, b=0° and for a dark matter profile centered at this location) previously reported in Fermi-LAT data. This new analysis overlaps significantly in energy with previous Fermi-LAT and H.E.S.S. No significant excess associated with dark matter annihilations was found in the energy range of 100 GeV to 2 TeV and upper limits on the gamma-ray flux and the velocity weighted annihilation cross section are derived adopting an Einasto dark matter halo profile. Expected limits for present and future large statistics H.E.S.S. observations are also given.

H.E.S.S. Limits on Linelike Dark Matter Signatures in the 100 GeV to 2 TeV Energy Range Close to the Galactic Center

NASA Astrophysics Data System (ADS)

Abdalla, H.; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Andersson, T.; Angüner, E. O.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Becker Tjus, J.; Berge, D.; Bernhard, S.; Bernlöhr, K.; Birsin, E.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Bulik, T.; Capasso, M.; Carr, J.; Casanova, S.; Chakraborty, N.; Chalme-Calvet, R.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Chrétien, M.; Colafrancesco, S.; Cologna, G.; Condon, B.; Conrad, J.; Couturier, C.; Cui, Y.; Davids, I. D.; Degrange, B.; Deil, C.; Devin, J.; deWilt, P.; Djannati-Ataï, A.; Domainko, W.; Donath, A.; Drury, L. O'C.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Edwards, T.; Egberts, K.; Eger, P.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Funk, S.; Füßling, M.; Gabici, S.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Gottschall, D.; Goyal, A.; Grondin, M.-H.; Grudzińska, M.; Hadasch, D.; Hahn, J.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holler, M.; Horns, D.; Ivascenko, A.; Jacholkowska, A.; Jamrozy, M.; Janiak, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jogler, T.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kerszberg, D.; Khélifi, B.; Kieffer, M.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Kraus, M.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lefranc, V.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Liu, R.; Lohse, T.; Lorentz, M.; Lypova, I.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Morâ, K.; Moulin, E.; Murach, T.; de Naurois, M.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Ohm, S.; Ostrowski, M.; Öttl, S.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Romoli, C.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Salek, D.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Simoni, R.; Sol, H.; Spanier, F.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tluczykont, M.; Trichard, C.; Tuffs, R.; van der Walt, J.; van Eldik, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zaborov, D.; Zacharias, M.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Żywucka, N.; H. E. S. S. Collaboration

2016-10-01

A search for dark matter linelike signals iss performed in the vicinity of the Galactic Center by the H.E.S.S. experiment on observational data taken in 2014. An unbinned likelihood analysis iss developed to improve the sensitivity to linelike signals. The upgraded analysis along with newer data extend the energy coverage of the previous measurement down to 100 GeV. The 18 h of data collected with the H.E.S.S. array allow one to rule out at 95% C.L. the presence of a 130 GeV line (at l =-1.5 ° , b =0 ° and for a dark matter profile centered at this location) previously reported in Fermi-LAT data. This new analysis overlaps significantly in energy with previous Fermi-LAT and H.E.S.S. results. No significant excess associated with dark matter annihilations was found in the energy range of 100 GeV to 2 TeV and upper limits on the gamma-ray flux and the velocity weighted annihilation cross section are derived adopting an Einasto dark matter halo profile. Expected limits for present and future large statistics H.E.S.S. observations are also given.

OPERATION HARDTACK. Project 3.5. Loading and Response of Submarine Hulls from Underwater Bursts

DTIC Science & Technology

1985-09-01

Bursts H. L. Rich, Project Officer F. Weinberger E. T. Habib R. L. Bor W. J. Sette David Taylor Model Basin Washington, DC 15 December 1960 NOTICE: This...Hulls from Underwater Bursts, Extracted Version 12. PERSONAL AUTHOR(S) Rich, H.L., Project Officer; Weinberger, F.; Habib , E.T.; Bort, R.L.; Sette, W.J...SLO A D IN G oa n d R E S P O N S E o f S U B M A R IN E tULLS from UNDERWATER BURSTS H. L. Rich, Project Officer F. Weinberger E.T. Habib R.L. Bort W

Effect of Storm Enhanced Densities on Geo-Location Accuracy over CONUS

DTIC Science & Technology

2011-09-15

s in G A IM -G M , u si n g th e A F W A g ri d . T h e le ft co lu m n sh o w s th e IF M b a ck g ro u n d s th a t G A IM -G M w a s re...cr ea ti n g , w h ic h h a d b ee n d ep le te d b y a fa ct o r o f 4 a b o

Deeper H.E.S.S. observations of Vela Junior (RX J0852.0-4622): Morphology studies and resolved spectroscopy

NASA Astrophysics Data System (ADS)

H.E.S.S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Angüner, E. O.; Arakawa, M.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Becker Tjus, J.; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Capasso, M.; Carr, J.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chalme-Calvet, R.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Chrétien, M.; Coffaro, M.; Colafrancesco, S.; Cologna, G.; Condon, B.; Conrad, J.; Cui, Y.; Davids, I. D.; Decock, J.; Degrange, B.; Deil, C.; Devin, J.; deWilt, P.; Dirson, L.; Djannati-Ataï, A.; Domainko, W.; Donath, A.; Drury, L. O.'C.; Dutson, K.; Dyks, J.; Edwards, T.; Egberts, K.; Eger, P.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Funk, S.; Füßling, M.; Gabici, S.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Gottschall, D.; Goyal, A.; Grondin, M.-H.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holler, M.; Horns, D.; Ivascenko, A.; Iwasaki, H.; Jacholkowska, A.; Jamrozy, M.; Janiak, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jogler, T.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katsuragawa, M.; Katz, U.; Kerszberg, D.; Khangulyan, D.; Khélifi, B.; Kieffer, M.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kolitzus, D.; Komin, Nu.; Krakau, S.; Kraus, M.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lefranc, V.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morå, K.; Moulin, E.; Murach, T.; Nakashima, S.; de Naurois, M.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Öttl, S.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Richter, S.; Rieger, F.; Romoli, C.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Saito, S.; Salek, D.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Simoni, R.; Sol, H.; Spanier, F.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stycz, K.; Sushch, I.; Takahashi, T.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tsuji, N.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zaborov, D.; Zacharias, M.; Zanin, R.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Żywucka, N.

2018-04-01

Aims: We study γ-ray emission from the shell-type supernova remnant (SNR) RX J0852.0-4622 to better characterize its spectral properties and its distribution over the SNR. Methods: The analysis of an extended High Energy Spectroscopic System (H.E.S.S.) data set at very high energies (E > 100 GeV) permits detailed studies, as well as spatially resolved spectroscopy, of the morphology and spectrum of the whole RX J0852.0-4622 region. The H.E.S.S. data are combined with archival data from other wavebands and interpreted in the framework of leptonic and hadronic models. The joint Fermi-LAT-H.E.S.S. spectrum allows the direct determination of the spectral characteristics of the parent particle population in leptonic and hadronic scenarios using only GeV-TeV data. Results: An updated analysis of the H.E.S.S. data shows that the spectrum of the entire SNR connects smoothly to the high-energy spectrum measured by Fermi-LAT. The increased data set makes it possible to demonstrate that the H.E.S.S. spectrum deviates significantly from a power law and is well described by both a curved power law and a power law with an exponential cutoff at an energy of Ecut = (6.7 ± 1.2stat ± 1.2syst) TeV. The joint Fermi-LAT-H.E.S.S. spectrum allows the unambiguous identification of the spectral shape as a power law with an exponential cutoff. No significant evidence is found for a variation of the spectral parameters across the SNR, suggesting similar conditions of particle acceleration across the remnant. A simple modeling using one particle population to model the SNR emission demonstrates that both leptonic and hadronic emission scenarios remain plausible. It is also shown that at least a part of the shell emission is likely due to the presence of a pulsar wind nebula around PSR J0855-4644. A FITS image of the region of interest and two text files describing the H.E.S.S. spectrum of RX J0852.0-4622 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/612/A7

Catalytic activity of Cu4-cluster to adsorb H2S gas: h-BN nanosheet

NASA Astrophysics Data System (ADS)

Kansara, Shivam; Gupta, Sanjeev K.; Sonvane, Yogesh

2018-05-01

We have investigated the electronic properties, adsorptions strength and charge transfer using first principles calculations using density functional theory (DFT). The hexagonal boron nitride (h-BN) substrate shows metallic behavior, which helps to enhance the absorption process. The adsorption of three different orientations (S, D and T) of the H2S gas molecules to analyze the maximum adsorption strength from them onto a copper cluster (Cu4) based on h-BN nanosheet. The maximum adsorption energy of the H2S gas molecule is -1.50 eV for the S orientation and for D and U, it is -0.71 eV and -0.78 eV, respectively. The results show that Cu4 cluster helps to capture H2S gas from the environment and results are useful for the cleaning environment from the toxic gases.

--No Title--

Science.gov Websites

m n _ 5 0 m _ m e t a d a t a _ f i l e s / f i l e l i s t . x m l " > < l i n k r e l = E d i t - T i m e - D a t a h r e f = " m n _ 5 0 m _ m e t a d a t a _ f i l e s / e d i t d a t a . m s o " > < ! - - [ i f ! m s o ] > < s t y l e > v \\ : * { b e h a v i o

System Synthesis for Polymorphous Computing Architectures

DTIC Science & Technology

2002-02-01

G H F Proc 5 : 4 : 3 11 1 Figure 3. Self-timed execution. D C B F G H E D B H EA CG F D C B F G H E D B H EA CG F AProc 1 Proc 2...first-iteration actors denoted by T. D B H E CG F D C B F G H E D B H EA CG F A 18 T T T T Proc 3 Proc 4 Proc 5 Proc 1 Proc 2 1 T⁄ T trmin30 ture-mirror...Phase1Algo( , ) = transientReduction( ) Output T G S′ S G T S′ S S′ Figure 11. Pseudocode to find

Metal-Arc Welded Ti-6Al-4V, Ti-4Al-4V, and Ti-5Al-2 and 1/2 SN Titanium Alloys

DTIC Science & Technology

1959-05-01

x . 7 8 8 - x 2 . 1 2 i n c h ) V n o t c h Charpy i m p a c t spec imen . MATERIALS COHN* .25 . 2 3 The m a t e r i a l s u s e d d...i e d V n o t c h Charpy i m p a c t spec imen i n a s t a n d a r d i m p a c t machine w i th anvi l s modified so t h a t the center...of percussion of the pendulum coincided with the center of the impact specimen, This FIGURE 3: SUBSIZE T E N S I L E SPECIMEN FIGURE 4

Analysis of Deep Attack Operations Operation Bagration Belorussia 22 June-29 August 1944

DTIC Science & Technology

1987-03-01

v e r s which almost all r a n n o r t h o r south, t h e Dnieper, Drut, Beres ina , Western Dvina, Svis loch, P t i ch , and Neman . A l l...2d BRB t o the - Neman , and 1st BRF t o the western Bug, on t h e borders o f Poland, f i n a l l y br inging his l e f t wing i n t o ac...bridgeheads over the Vis tu l a River, as wel l a s t h e f u l l cross ing of t h e Neman and Narev Rivera on t h e way t o East Pmss ia

Accretion-powered Compact Binaries

NASA Astrophysics Data System (ADS)

Mauche, Christopher W.

2003-12-01

Preface; The workshop logo; A short history of the CV workshop F. A. Córdova; Part I. Observations: 1. Low mass x-ray binaries A. P. Cowley, P. C. Schmidtke, D. Crampton, J. B. Hutchings, C. A. Haswell, E. L. Robinson, K. D. Horne, H. M. Johnston, S. R. Kulkarni, S. Kitamoto, X. Han, R. M. Hjellming, R. M. Wagner, S. L. Morris, P. Hertz, A. N. Parmar, L. Stella, P. Giommi, P. J. Callanan, T. Naylor, P. A. Charles, C. D. Bailyn, J. N. Imamura, T. Steiman-Cameron, J. Kristian, J. Middleditch, L. Angelini and J. P. Noris; 2. Nonmagnetic cataclysmic variables R. S. Polidan, C. W. Mauche, R. A. Wade, R. H. Kaitchuck, E. M. Schlegel, P. A. Hantzios, R. C. Smith, J. H. Wood, F. Hessman, A. Fiedler, D. H. P. Jones, J. Casares, P. A. Charles, J. van Paradijs, E. Harlaftis, T. Naylor, G. Sonneborn, B. J. M. Hassall, K. Horne, C. A. la Dous, A. W. Shafter, N. A. Hawkins, D. A. H. Buckley, D. J. Sullivan, F. V. Hessman, V. S. Dhillon, T. R. Marsh, J. Singh, S. Seetha, F. Giovannelli, A. Bianchini, E. M. Sion, D. J. Mullan, H. L. Shipman, G. Machin, P. J. Callanan, S. B. Howell, P. Szkody, E. M. Schlegel and R. F. Webbink; 3. Magnetic cataclysmic variables C. Hellier, K. O. Mason, C. W. Mauche, G. S. Miller, J. C. Raymond, F. K. Lamb, J. Patterson, A. J. Norton, M. G. Watson, A. R. King, I. M. McHardy, H. Lehto, J. P. Osborne, E. L. Robinson, A. W. Shafter, S. Balachandran, S. R. Rosen, J. Krautter, W. Buchholz, D. A. H. Buckley, I. R. Tuoly, D. Crampton, B. Warner, R. M. Prestage, B. N. Ashoka, M. Mouchet, J. M. Bonnet-Bidaud, J. M. Hameury, P. Szkody, P. Garnavich, S. Howell, T. Kii, M. Cropper, K. Mason, J. Bailey, D. T. Wickramasinghe, L. Ferrario, K. Beuermann, A. D. Schwope, H.-C. Thomas, S. Jordan, J. Schachter, A. V. Filippenko, S. M. Kahn, F. B. S. Paerels, K. Mukai, M. L. Edgar, S. Larsson, R. F. Jameson, A. R. King, A. Silber, R. Remillard, H. Bradt, M. Ishida, T. Ohashi and G. D. Schmidt; Part II. Accretion Theory: 4. Nonmagnetic W. Kley, F. Geyer, H. Herold, H. Ruder, R. Whitehurst, A. King, J. C. Wheeler, S. Mineshige, M. Huang, S. W. Kim, Y. Tuchman, T. R. Kallman and J. A. Woods; 5. Magnetic M. T. Wolff, J. N. Imamura, K. S. Wood, J. H. Gardner, S. J. Litchfield, J. J. Brainerd, G. Chanmugan, K. Wu, J. Frank, T. Hanawa, K. Hirotani and N. Kawai; Part III. Novae S. Starrfield, R. M. Hjellming, A. B. Tomaney, A. W. Shafter, A. Cassatella, P. L. Selvelli, R. Gilmozzi, A. Bianchini, M. Friedjung, H. Ritter, M. J. Politano, M. Livio, R. F. Webbink, K. Horne, W. F. Welsh, R. A. Wade, J. Krauttler, M. A. J. Snijders, N. Vogt, L. H. Barrera, H. Barwig, K.-H Mantel, R. Gilmozzi, A. Shankar, A. Burkert, J. W. Truran and J. Hayes: Part IV. Evolution I. Iben Jr, M. S. Hjellming, R. E. Taam, M. Politano, F. D'Antona, I. Mazzitelli, H. Ritter, J. M. Hameury, A. R. King, J. P. Lasota, R. Popham, R. Narayan, J. Isern, J. Laybay, R. Canal, D. García, A. S. Fruchter, S. R. Kulkarni, R. W. Romani, A. Ray, W. Kluzniak, S. Miyaji and G. Chanmugam; Subject index; Star index.

Personality and Politics: The Untold Story of Robert S. McNamara and Curtis E. Lemay

DTIC Science & Technology

2012-06-01

James H. Douglas, Jr . F.F. Everest William C. Garland Harry E. Goldsworthy Brian S. Gunderson Ernest C. Hardin, Jr . Michael J. Ingelido Leon W...Schriever Alton D. Slay Frederick H. Smith F.H. Smith, Jr . Guyford H. Steven Maxwell D. Taylor John W. Vogt Adriel N. Williams E.M. Zuckert...of Oahu, Hawaii. 22 Curtis E. LeMay Oral History Interview conducted by Edgar F. Puryear, Jr . 17

Syntheses of halogen derivatives of L-tryptophan, L-tyrosine and L-phenylalanine labeled with hydrogen isotopes.

PubMed

Pająk, Małgorzata; Pałka, Katarzyna; Winnicka, Elżbieta; Kańska, Marianna

2016-01-01

Halogenated, labeled with tritium and doubly with deuterium and tritium, derivatives of L-tryptophan, i.e. 5'-bromo-[2-(3)H]-, 5'-bromo-[2-(2)H/(3)H]-, 5'-fluoro-[2-(3)H]-5'-fluoro-[2-(2)H/(3)H]-, 6'-fluoro-[2-(3)H]-, 6'-fluoro-[2-(2)H/(3)H]-L-tryptophan, as well as, L-tyrosine, i.e. 3'-fluoro-[2-(3)H]-, 3'-fluoro-[2-(2)H/(3)H]-, 3'-chloro-[2-(3)H]-, and 3'-chloro-[2-(2)H/(3)H]-L-tyrosine, and also L-phenylalanine, i.e. 2'-fluoro-[(3S)-(3)H]-, 2'-fluoro-[(3S)-(2)H/(3) H]-, 2'-chloro-[(3S)-(3)H]-, 2'-chloro-[(3S)-(2)H/(3)H]-, 4'-chloro-[(3S)-(3)H]-, and 4'-chloro-[(3S)-(2)H/(3)H]-L-phenylalanine were synthesized using enzymatic methods. Isotopomers of L-tryptophan were synthesized by coupling of halogenated indoles with S-methyl-L-cysteine carried out in deuteriated or tritiated incubation media. Labeled halogenated derivatives of L-tyrosine were obtained by the enzymatically supported exchange between halogenated L-tyrosine and isotopic water. Labeled halogenated isotopologues of L-Phe were synthesized by the enzymatic addition of ammonia to halogenated cinnamic acid. As a source of hydrogen tritiated water (HTO) and heavy water (D2O) with addition of HTO were used. Copyright © 2015 John Wiley & Sons, Ltd.

Army Ordnance Satellite Program

DTIC Science & Technology

1958-11-01

i t e h i s t o r y , beginning with s c i e n t i s t s Hermann Oberth and Robert Goddard a f t e r World War I. S t i l l t o be w r i t t e...satellite program really began with the fiction-like story of Professor Hermann Oberth , "father of 1 astronautics," Born in Hernannstadt...solved t h i s g r e a t problem, Yours very t r u l y Hermann Oberth , Student Hath, Heidelbergn This l e t t e r was w r i t t e n e a r l y i n

Search for TeV Gamma-ray Emission from GRB 100621A, an extremely bright GRB in X-rays, with H.E.S.S.

NASA Astrophysics Data System (ADS)

H.E.S.S. Collaboration; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Angüner, E.; Anton, G.; Balenderan, S.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker Tjus, J.; Bernlöhr, K.; Birsin, E.; Bissaldi, E.; Biteau, J.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Carrigan, S.; Casanova, S.; Cerruti, M.; Chadwick, P. M.; Chalme-Calvet, R.; Chaves, R. C. G.; Cheesebrough, A.; Chrétien, M.; Colafrancesco, S.; Cologna, G.; Conrad, J.; Couturier, C.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; deWilt, P.; Dickinson, H. J.; Djannati-Ataï, A.; Domainko, W.; O'C. Drury, L.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Edwards, T.; Egberts, K.; Eger, P.; Espigat, P.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giebels, B.; Glicenstein, J. F.; Grondin, M.-H.; Grudzińska, M.; Häffner, S.; Hahn, J.; Harris, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; Jahn, C.; Jamrozy, M.; Janiak, M.; Jankowsky, F.; Jung, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Khélifi, B.; Kieffer, M.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kneiske, T.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lefaucheur, J.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Lennarz, D.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Méhault, J.; Menzler, U.; Meyer, M.; Moderski, R.; Mohamed, M.; Moulin, E.; Murach, T.; Naumann, C. L.; de Naurois, M.; Niemiec, J.; Nolan, S. J.; Oakes, L.; O'Brien, P. T.; Ohm, S.; de Oña Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Poon, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Raue, M.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Rob, L.; Romoli, C.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sol, H.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Szostek, A.; Tam, P. H. T.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tluczykont, M.; Trichard, C.; Valerius, K.; van Eldik, C.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Völk, H. J.; Volpe, F.; Vorster, M.; Wagner, S. J.; Wagner, P.; Ward, M.; Weidinger, M.; Weitzel, Q.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Zacharias, M.; Zajczyk, A.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.

2014-05-01

The long gamma-ray burst (GRB) 100621A, at the time the brightest X-ray transient ever detected by Swift-XRT in the 0.3-10 keV range, has been observed with the H.E.S.S. imaging air Cherenkov telescope array, sensitive to gamma radiation in the very-high-energy (VHE, >100 GeV) regime. Due to its relatively small redshift of z ~ 0.5, the favourable position in the southern sky and the relatively short follow-up time (<700 s after the satellite trigger) of the H.E.S.S. observations, this GRB could be within the sensitivity reach of the H.E.S.S. instrument. The analysis of the H.E.S.S. data shows no indication of emission and yields an integral flux upper limit above ~380 GeV of 4.2 × 10-12 cm-2 s-1 (95% confidence level), assuming a simple Band function extension model. A comparison to a spectral-temporal model, normalised to the prompt flux at sub-MeV energies, constraints the existence of a temporally extended and strong additional hard power law, as has been observed in the other bright X-ray GRB 130427A. A comparison between the H.E.S.S. upper limit and the contemporaneous energy output in X-rays constrains the ratio between the X-ray and VHE gamma-ray fluxes to be greater than 0.4. This value is an important quantity for modelling the afterglow and can constrain leptonic emission scenarios, where leptons are responsible for the X-ray emission and might produce VHE gamma rays.

H2S adsorption and dissociation on NH-decorated graphene: A first principles study

NASA Astrophysics Data System (ADS)

Faye, Omar; Eduok, Ubong; Szpunar, Jerzy; Samoura, Almoustapha; Beye, Aboubaker

2018-02-01

The removal of H2S gas poses an emerging environmental concern because of the lack of knowledge of an efficient adsorbent. A detailed theoretical study of H2S adsorption and dissociation on NH-doped graphene (GNH) has been carried out by means of density theory calculations. Our results reveal that the adsorption of H2S molecule on GNH composite is enhanced by the presence of active site such as the NH radicals. These NH radical sites formed NHsbnd H bonds and increase the charge transfer from H2S to GNH. The dissociation of the adsorbed H2S molecule leads the chemisorption of SH radical via H-transfer to GNH, while the formation of GNH2 at a weight percent of 3.76 wt% of NH radical is an endothermic process with an energy of 0.299 eV and 0.358 eV for ortho and para-position respectively. However, at 7.25 wt% NH radical, we observed a complete dissociation of H2S molecule with an energy released of 0.711 eV for the chemisorbed S atom on GN2H4. Moreover, the H-transfer of the second H atom of H2S molecule at 3.76 wt% was energetic unfavorable. The trend of predicted results within this study reveals that NH-doped graphene (GNH) successfully adsorbed and eliminated of H2S molecule; this work unveils definitive theoretical procedures which can be tested and validated experimentally.

Final Environmental Assessment Test Operations at Arnold Engineering Development Center. Volumes 1 & 2

DTIC Science & Technology

2008-06-01

ir Fo rc e B as e, T en ne ss ee Fi gu re 1 -2 A er od yn am ic s A er op ro pu ls io n S pa ce & M is si le In fr as...lin es /te xt - fa ci lit ie s in s ta nd by o r m ot hb al le d st at us H ea lth , S af et y an d E nv ir on m en ta l M an ag em en t S ys...yp er so ni c C A er ot he rm al C A FC L La b H E AT -H 2 C C O S

Temporal Fluctuation of Multidrug Resistant Salmonella Typhi Haplotypes in the Mekong River Delta Region of Vietnam

PubMed Central

Chau, Tran Thuy; Duy, Pham Thanh; La, Tran Thi Phi; Hoang, Nguyen Van Minh; Nga, Tran Vu Thieu; Campbell, James I.; Manh, Bui Huu; Vinh Chau, Nguyen Van; Hien, Tran Tinh; Farrar, Jeremy; Dougan, Gordon; Baker, Stephen

2011-01-01

Background Typhoid fever remains a public health problem in Vietnam, with a significant burden in the Mekong River delta region. Typhoid fever is caused by the bacterial pathogen Salmonella enterica serovar Typhi (S. Typhi), which is frequently multidrug resistant with reduced susceptibility to fluoroquinolone-based drugs, the first choice for the treatment of typhoid fever. We used a GoldenGate (Illumina) assay to type 1,500 single nucleotide polymorphisms (SNPs) and analyse the genetic variation of S. Typhi isolated from 267 typhoid fever patients in the Mekong delta region participating in a randomized trial conducted between 2004 and 2005. Principal Findings The population of S. Typhi circulating during the study was highly clonal, with 91% of isolates belonging to a single clonal complex of the S. Typhi H58 haplogroup. The patterns of disease were consistent with the presence of an endemic haplotype H58-C and a localised outbreak of S. Typhi haplotype H58-E2 in 2004. H58-E2-associated typhoid fever cases exhibited evidence of significant geo-spatial clustering along the Sông H u branch of the Mekong River. Multidrug resistance was common in the established clone H58-C but not in the outbreak clone H58-E2, however all H58 S. Typhi were nalidixic acid resistant and carried a Ser83Phe amino acid substitution in the gyrA gene. Significance The H58 haplogroup dominates S. Typhi populations in other endemic areas, but the population described here was more homogeneous than previously examined populations, and the dominant clonal complex (H58-C, -E1, -E2) observed in this study has not been detected outside Vietnam. IncHI1 plasmid-bearing S. Typhi H58-C was endemic during the study period whilst H58-E2, which rarely carried the plasmid, was only transient, suggesting a selective advantage for the plasmid. These data add insight into the outbreak dynamics and local molecular epidemiology of S. Typhi in southern Vietnam. PMID:21245916

Investigation of a Cesium Raman Time/Frequency Standard

DTIC Science & Technology

1991-12-01

0. 1 4 XZ E(r, t) = ’h/(El(r)exp(- iwlt ) + c.c.) 0 + ’/,(E 2(r)exp(- iw.2t) + c.c.). (2) - /2 eAll remaining notations are defined in Table 1. By...h P - P33 Rabi frequency for 3-2 transition 92 = 623 E2 )/h [ [r Rotating-wave (a~~012 = P12 exp(- iwlt ) S 0 0i 2Ra 1 1f2sRotating-wav e a,3 2 e p(-i

Recommended Values of the Thermophysical Properties of Eight Alloys, Major Constituents and Their Oxides

DTIC Science & Technology

1966-01-01

V & 1? MATERIALS 732 e a ja o 8 i 1* •ŗ •3V h Q £ u HO > HS MSB Q »H ELEMENTS...CO e - « « s M u I 2 H t- xti CO in eo N i o 7 o T-S T-1110 ""A ’ityAnonpuoo iBttueqx -•-■-■-- - ■ - ^ H.^’.^" V ...IO CO M i-t •O COCS O tr- lO CON I s e IO 05 w O Ü o Ü I g E 1_5I ,_uio JJBM ’AiAnonpuoo iBrajaqi i V

Aircraft Observations for Improved Physical Parameterization for Seasonal Prediction

DTIC Science & Technology

2013-09-30

platform is ready for use in air-sea interaction research projects. RELATED PROJECTS None PUBLICATIONS Gerber H., G. Frick, S. Malinowski ... Malinowski , S. P., H. Gerber, I. Jen-LaPlante, M. K. Kopec, W. Kumala, K. Nurowska, P. Y. Chuang, K. E. Haman, D. D. Khelif, S. K. Krueger, and H. H. Jonsson...Haman, K. E., Kopec, M. K., Khelif, D., and Malinowski , S. P.: Modified ultrafast thermometer UFT-M and temperature measurements during Physics of

Flight Problems, Problems in Starting Service,

DTIC Science & Technology

1977-01-03

h i l e a t the same time preserving hi gh f l i g h t r egu la r i t~ l e a d s to t h e fa c t t h a t the t e c h n i cal s t a r t i n g... assembl ies and pa r t s of the a i r c r a f t d~ein the previous flight (R R ), the p r o b a b i l i t y of4pr esence in the landing airport of an...of the assemblies , sets and blocks /P.- can be exchange d in a single hour in case of defects. Furthermore , in the newly constructed L-lOll

Beta Human Chorionic Gonadotropin - Induction of Apoptosis in Breast Cancer

DTIC Science & Technology

2006-01-01

R., Sturzl, M ., Albini, A., Tschachler, E., Zangerle, R., Donini , S., Feichtinger, H., Schwarz, S., 1997. Induction of apoptosis in Kaposi’s...Roth, B., Bock, G., Recheis, H., Sgonc, R., Sturzl, M ., Albini, A., 18 Tschachler, E., Zangerle, R., Donini , S., Feichtinger, H., Schwarz, S., 1997...Biol. Anim. 30A, 4-8. Bièche, I., Lazar, V., Noguès, C., Poynard, T., Giovangrandi, Y., Bellet, D., Lidereau, R., Vidaud, M ., 1998. Prognostic value

David Miller | NREL

Science.gov Websites

Publications D.C. Miller, E. Annigoni, A. Ballion, J.G. Bokria, L.S. Bruckman, D.M. Burns, X. Chen, L. Elliott , J. Feng, R.H. French, S. Fowler, C.C. Honeker, M.D. Kempe, H. Khonkar, M. Köhl, L.-E. Perret-Aebi , L. Elliott, L. Feng, R.H. French, S. Fowler, X. Gu, P.L. Hacke, C.C. Honeker, M.D. Kempe, H. Khonkar

Biophysical Aspects of Cyclodextrin Interaction with Paraoxon

DTIC Science & Technology

2013-12-19

Rockville, MD, USA article is a U.S. Government work and is in the public domain in the USA. 1 1 1 Figure 2. NMR analysis of paraoxon (PX) and β-CD...interaction. Job’s plot analysis (continuous variation method) was performed for β-CD H1’, H2’, and H4’ protons and is shown in a–c respectively. The PX...resonances analyzed using nonlinear regression analysis for a. H1’, b. H2’, c. H5’, d. H2 H8, and e. H3 H5. S.-D. Soni, J. B. Bhonsle and G. E. Garcia

China’s ASAT Test: Motivations and Implications

DTIC Science & Technology

2007-01-01

h i l l i P c . S a u n D e r S and c h a r l e S D . l u t e S Dr. Phillip C. saunders and Colonel Charles D. Lutes, UsaF, are senior Research...at <www.aviationweek.com/aw/generic/story_generic. jsp?channel= awst &id=news/aw012207p2.xml>. 11 Chris Buckley, “China confirms satellite test, says

Microwave Spectrum of the H_2S Dimer: Observation of K_{a}=1 Lines

NASA Astrophysics Data System (ADS)

Das, Arijit; Mandal, Pankaj; Lovas, Frank J.; Medcraft, Chris; Arunan, Elangannan

2017-06-01

Large amplitude tunneling motions in (H_2S)_{2} complicate the analysis of its microwave spectrum. The previous rotational spectrum of (H_2S)_{2} was observed using the Balle-Flygare pulsed nozzle FT microwave spectrometers at NIST and IISc. For most isotopomers of (H_2S)_{2} a two state pattern of a-type K_{a}=0 transitions had been observed and were interpreted to arise from E_{1}^{+/-} and E_{2}^{+/-} states of the six tunneling states expected for (H_2S)_{2}. K_{a}=0 lines gave us only the distance between the acceptor and donor S atoms. The (B+C)/2 for E_{1} and E_{2} states were found to be 1749.3091(8) MHz and 1748.1090(8) MHz respectively. In this work, we have observed the K_{a}=1 microwave transitions which enable us to determine finer structural details of the dimer. The observation of the K_{a}=1 lines indicate that (H_2S)_{2} is not spherical in nature, their interactions do have some anisotropy. Preliminary assignment of K_{a}=1 lines for the E_{1} state results in B=1752.859 MHz and C=1745.780 MHz. We also report a new progression of lines which probably belongs to the parent isotopomers. F. J. Lovas, P. K. Mandal and E. Arunan, unpublished work P. K. Mandal Ph.D. Dissertation, Indian Institute of Science, (2005) F. J. Lovas, R. D. Suenram, and L. H. Coudert. 43rd Int.Symp. on Molecular Spectroscopy. (1988)

TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h

PubMed Central

Schepetilnikov, Mikhail; Dimitrova, Maria; Mancera-Martínez, Eder; Geldreich, Angèle; Keller, Mario; Ryabova, Lyubov A

2013-01-01

Mammalian target-of-rapamycin (mTOR) triggers S6 kinase (S6K) activation to phosphorylate targets linked to translation in response to energy, nutrients, and hormones. Pathways of TOR activation in plants remain unknown. Here, we uncover the role of the phytohormone auxin in TOR signalling activation and reinitiation after upstream open reading frame (uORF) translation, which in plants is dependent on translation initiation factor eIF3h. We show that auxin triggers TOR activation followed by S6K1 phosphorylation at T449 and efficient loading of uORF-mRNAs onto polysomes in a manner sensitive to the TOR inhibitor Torin-1. Torin-1 mediates recruitment of inactive S6K1 to polysomes, while auxin triggers S6K1 dissociation and recruitment of activated TOR instead. A putative target of TOR/S6K1—eIF3h—is phosphorylated and detected in polysomes in response to auxin. In TOR-deficient plants, polysomes were prebound by inactive S6K1, and loading of uORF-mRNAs and eIF3h was impaired. Transient expression of eIF3h-S178D in plant protoplasts specifically upregulates uORF-mRNA translation. We propose that TOR functions in polysomes to maintain the active S6K1 (and thus eIF3h) phosphorylation status that is critical for translation reinitiation. PMID:23524850

Arginine methyltransferase inhibitor 1 inhibits gastric cancer by downregulating eIF4E and targeting PRMT5.

PubMed

Zhang, Baolai; Zhang, Su; Zhu, Lijuan; Chen, Xue; Zhao, Yunfeng; Chao, Li; Zhou, Juanping; Wang, Xing; Zhang, Xinyang; Ma, Nengqian

2017-12-01

Arginine methylation is carried out by protein arginine methyltransferase (PRMTs) family. Arginine methyltransferase inhibitor 1 (AMI-1) is mainly used to inhibit type I PRMT activity in vitro. However, the effects of AMI-1 on type II PRMT5 activity and gastric cancer (GC) remain unclear. In this study, we provided the first evidence that AMI-1 significantly inhibited GC cell proliferation and migration while induced GC cell apoptosis, and reduced the expression of PRMT5, eukaryotic translation initiation factor 4E (eIF4E), symmetric dimethylation of histone 3 (H3R8me2s) and histone 4 (H4R3me2s). In addition, AMI-1 inhibited tumor growth, downregulated eIF4E, H4R3me2s and H3R8me2s expression in mice xenografts model of GC. Collectively, our results suggest that AMI-1 inhibits GC by downregulating eIF4E and targeting type II PRMT5. Copyright © 2017 Elsevier Inc. All rights reserved.

Canada’s First National Interoperability Baseline Assessment: CPRC 91052 Project Study

DTIC Science & Technology

2012-03-01

Time and Leadership. 33 Y on ge S t ., S ui te 4 20 , T or on to , O nt ar io C an ad a, M 5E 1 G 4 #91052 T A B L E O F C O N T E N T ...28  Essential Guidance 30   #91052 L I S T O F F I G U R E S P 1 Demographics...30 #91052 1 I N T H I S S T U D Y M e t h o d o l o g y This study was based on a web survey of 105

CD15s/CD62E Interaction Mediates the Adhesion of Non-Small Cell Lung Cancer Cells on Brain Endothelial Cells: Implications for Cerebral Metastasis.

PubMed

Jassam, Samah A; Maherally, Zaynah; Smith, James R; Ashkan, Keyoumars; Roncaroli, Federico; Fillmore, Helen L; Pilkington, Geoffrey J

2017-07-10

Expression of the cell adhesion molecule (CAM), Sialyl Lewis X (CD15s) correlates with cancer metastasis, while expression of E-selectin (CD62E) is stimulated by TNF-α. CD15s/CD62E interaction plays a key role in the homing process of circulating leukocytes. We investigated the heterophilic interaction of CD15s and CD62E in brain metastasis-related cancer cell adhesion. CD15s and CD62E were characterised in human brain endothelium (hCMEC/D3), primary non-small cell lung cancer (NSCLC) (COR-L105 and A549) and metastatic NSCLC (SEBTA-001 and NCI-H1299) using immunocytochemistry, Western blotting, flow cytometry and immunohistochemistry in human brain tissue sections. TNF-α (25 pg/mL) stimulated extracellular expression of CD62E while adhesion assays, under both static and physiological flow live-cell conditions, explored the effect of CD15s-mAb immunoblocking on adhesion of cancer cell-brain endothelium. CD15s was faintly expressed on hCMEC/D3, while high levels were observed on primary NSCLC cells with expression highest on metastatic NSCLC cells ( p < 0.001). CD62E was highly expressed on hCMEC/D3 cells activated with TNF-α, with lower levels on primary and metastatic NSCLC cells. CD15s and CD62E were expressed on lung metastatic brain biopsies. CD15s/CD62E interaction was localised at adhesion sites of cancer cell-brain endothelium. CD15s immunoblocking significantly decreased cancer cell adhesion to brain endothelium under static and shear stress conditions ( p < 0.001), highlighting the role of CD15s-CD62E interaction in brain metastasis.

In Vivo Interactions Between Cobalt or Ferric Compounds and the Pools of Sulphide in the Blood During and After H2S Poisoning

PubMed Central

Haouzi, Philippe; Sonobe, Takashi; Torsell-Tubbs, Nicole; Prokopczyk, Bogdan; Chenuel, Bruno; Klingerman, Candice M.

2014-01-01

Hydrogen sulphide (H2S), a chemical hazard in oil and gas production, has recently become a dreadful method of suicide, posing specific risks and challenges for the first responders. Currently, there is no proven effective treatment against H2S poisoning and its severe neurological, respiratory or cardiac after-effects. We have recently described that H2S is present in various compartments, or pools, in the body during sulphide exposure, which have different levels of toxicity. The general goals of our study were to (1) determine the concentrations and kinetics of the various pools of hydrogen sulphide in the blood, i.e., gaseous (CgH2S) versus total sulphide, i.e., reacting with monobromobimane (CMBBH2S), during and following H2S exposure in a small and large mammal and (2) establish the interaction between the pools of H2S and a methemoglobin (MetHb) solution or a high dose of hydroxocobalamin (HyCo). We found that CgH2S during and following H2S infusion was similar in sedated sheep and rats at any given rate of infusion/kg and provoked symptoms, i.e., hyperpnea and apnea, at the same CgH2S. After H2S administration was stopped, CgH2S disappeared within 1 min. CMBBH2S also dropped to 2–3μM, but remained above baseline levels for at least 30 min. Infusion of a MetHb solution during H2S infusion produced an immediate reduction in the free/soluble pool of H2S only, whereas CMBBH2S increased by severalfold. HyCo (70 mg/kg) also decreased the concentrations of free/soluble H2S to almost zero; CgH2S returned to pre-HyCo levels within a maximum of 20 min, if H2S infusion is maintained. These results are discussed in the context of a relevant scenario, wherein antidotes can only be administered after H2S exposure. PMID:25015662

24 CFR 16.15 - Specific exemptions.

Code of Federal Regulations, 2010 CFR

2010-04-01

...), (e)(1), (e)(4) (G), (H), (I), and (f). This exemption allows the Department to withhold records... under 5 U.S.C. 552(k)(5) from the requirements of 5 U.S.C. 552a (c)(3), (d), (e)(1), (e)(4), (G), (H... subsection (e)(1) because it is often impossible to determine relevance or necessity of information in pre...

Final Environmental Impact Statement for the Strategic Target System. Volume III

DTIC Science & Technology

1992-05-01

HH e . = - - A. H -O , ai ^ V-w;^M3J ^3 c +*’’ Q in tn a in ’■*5i iii +> jB ^f* TT-P...a a « HH -IUOJ m •£ a HŔ JJ • rH»J JJ-H « O B c u a H OJJ «^ w-i c s s a a Ö H a JJ fto BBC -H u^ U "W BUBO 0££ ɠ O...3 <§ E"S"§ « ö •S<S 00« gŖ O n> ■ £ a * BO 1 > I B JB S « - £ B 8 ^ O C O tj K I- O D, =« ° ° "O "P^MO’C S « S -S *" «

The effects of elevated CO2 and nitrogen fertilization on stomatal conductance estimated from 11 years of scaled sap flux measurements at Duke FACE.

PubMed

Ward, Eric J; Oren, Ram; Bell, David M; Clark, James S; McCarthy, Heather R; Kim, Hyun-Seok; Domec, Jean-Christophe

2013-02-01

In this study, we employ a network of thermal dissipation probes (TDPs) monitoring sap flux density to estimate leaf-specific transpiration (E(L)) and stomatal conductance (G(S)) in Pinus taeda (L.) and Liquidambar styraciflua L. exposed to +200 ppm atmospheric CO(2) levels (eCO(2)) and nitrogen fertilization. Scaling half-hourly measurements from hundreds of sensors over 11 years, we found that P. taeda in eCO(2) intermittently (49% of monthly values) decreased stomatal conductance (G(S)) relative to the control, with a mean reduction of 13% in both total E(L) and mean daytime G(S). This intermittent response was related to changes in a hydraulic allometry index (A(H)), defined as sapwood area per unit leaf area per unit canopy height, which decreased a mean of 15% with eCO(2) over the course of the study, due mostly to a mean 19% increase in leaf area (A(L)). In contrast, L. styraciflua showed a consistent (76% of monthly values) reduction in G(S) with eCO(2) with a total reduction of 32% E(L), 31% G(S) and 23% A(H) (due to increased A(L) per sapwood area). For L. styraciflua, like P. taeda, the relationship between A(H) and G(S) at reference conditions suggested a decrease in G(S) across the range of A(H). Our findings suggest an indirect structural effect of eCO(2) on G(S) in P. taeda and a direct leaf level effect in L. styraciflua. In the initial year of fertilization, P. taeda in both CO(2) treatments, as well as L. styraciflua in eCO(2), exhibited higher G(S) with N(F) than expected from shifts in A(H), suggesting a transient direct effect on G(S). Whether treatment effects on mean leaf-specific G(S) are direct or indirect, this paper highlights that long-term treatment effects on G(S) are generally reflected in A(H) as well.

Some Investigations Relating to the Elastostatics of a Tapered Tube

DTIC Science & Technology

1978-03-01

regularity of the solution on the Z axis. Indeed the assumption of such’regularity is stated explicitly by Heins (p. 789) and the problems solved (e.g. a... assumptions , becomes where t h e integrand is evaluated a t ( + i ,O). This i s a form P a of t he i n t e g r a l representa t ion of t h e...solut ion. Now l e t us look a t t h e assumptions on Q. F i r s t of a l l , i n order t o be sure t h a t our operations a r e l eg i

Edge-to-Stem Variability in Wet-Canopy Evaporation From an Urban Tree Row

NASA Astrophysics Data System (ADS)

Van Stan, John T.; Norman, Zachary; Meghoo, Adrian; Friesen, Jan; Hildebrandt, Anke; Côté, Jean-François; Underwood, S. Jeffrey; Maldonado, Gustavo

2017-11-01

Evaporation from wet-canopy (E_C) and stem (E_S) surfaces during rainfall represents a significant portion of municipal-to-global scale hydrologic cycles. For urban ecosystems, E_C and E_S dynamics play valuable roles in stormwater management. Despite this, canopy-interception loss studies typically ignore crown-scale variability in E_C and assume (with few indirect data) that E_S is generally {<}2% of total wet-canopy evaporation. We test these common assumptions for the first time with a spatially-distributed network of in-canopy meteorological monitoring and 45 surface temperature sensors in an urban Pinus elliottii tree row to estimate E_C and E_S under the assumption that crown surfaces behave as "wet bulbs". From December 2015 through July 2016, 33 saturated crown periods (195 h of 5-min observations) were isolated from storms for determination of 5-min evaporation rates ranging from negligible to 0.67 mm h^{-1}. Mean E_S (0.10 mm h^{-1}) was significantly lower (p < 0.01) than mean E_C (0.16 mm h^{-1}). But, E_S values often equalled E_C and, when scaled to trunk area using terrestrial lidar, accounted for 8-13% (inter-quartile range) of total wet-crown evaporation (E_S+E_C scaled to surface area). E_S contributions to total wet-crown evaporation maximized at 33%, showing a general underestimate (by 2-17 times) of this quantity in the literature. Moreover, results suggest wet-crown evaporation from urban tree rows can be adequately estimated by simply assuming saturated tree surfaces behave as wet bulbs, avoiding problematic assumptions associated with other physically-based methods.

Proton and hydrogen transport through two-dimensional monolayers

NASA Astrophysics Data System (ADS)

Seel, Max; Pandey, Ravindra

2016-06-01

Diffusion of protons and hydrogen atoms in representative two-dimensional materials is investigated. Specifically, density functional calculations were performed on graphene, hexagonal boron nitride (h-BN), phosphorene, silicene, and molybdenum disulfide (MoS2) monolayers to study the surface interaction and penetration barriers for protons and hydrogen atoms employing finite cluster models. The calculated barrier heights correlate approximately with the size of the opening formed by the three-fold open sites in the monolayers considered. They range from 1.56 eV (proton) and 4.61 eV (H) for graphene to 0.12 eV (proton) and 0.20 eV (H) for silicene. The results indicate that only graphene and h-BN monolayers have the potential for membranes with high selective permeability. The MoS2 monolayer behaves differently: protons and H atoms become trapped between the outer S layers in the Mo plane in a well with a depth of 1.56 eV (proton) and 1.5 eV (H atom), possibly explaining why no proton transport was detected, suggesting MoS2 as a hydrogen storage material instead. For graphene and h-BN, off-center proton penetration reduces the barrier to 1.38 eV for graphene and 0.11 eV for h-BN. Furthermore, Pt acting as a substrate was found to have a negligible effect on the barrier height. In defective graphene, the smallest barrier for proton diffusion (1.05 eV) is found for an oxygen-terminated defect. Therefore, it seems more likely that thermal protons can penetrate a monolayer of h-BN but not graphene and defects are necessary to facilitate the proton transport in graphene.

Effectiveness of the Hydrogen Sulfide Test as a Water Quality Indicator for Diarrhea Risk in Rural Bangladesh

PubMed Central

Islam, Mahfuza; Ercumen, Ayse; Naser, Abu Mohd; Unicomb, Leanne; Rahman, Mahbubur; Arnold, Benjamin F.; Colford, Jr., John M.; Luby, Stephen P.

2017-01-01

Abstract. Microbiological water quality is usually assessed by the identification of Escherichia coli (E. coli), a fecal indicator. The hydrogen sulfide (H2S) test is an inexpensive, easy-to-use, and portable alternative field-based water quality test. Our study evaluated the H2S test’s effectiveness as a water quality indicator for diarrhea risk. Field workers collected stored drinking water samples for H2S analysis and detection of E. coli by membrane filtration and measured caregiver-reported diarrhea among children < 5 years in the same households 1 month later. We assessed the association between the H2S test (incubated for 24 hours and 48 hours) and diarrhea prevalence, with 2-day and 7-day symptom recall periods (N = 1,348). We determined the sensitivity, specificity, and positive and negative predictive value (PPV, NPV) of the H2S test compared with E. coli (N = 525). Controlling for potentially confounding covariates, H2S-positive water (at 24 or 48 hours) was not associated with 2-day diarrhea prevalence (24-hour prevalence ratio [PR] = 1.03, 95% confidence interval [CI]: 0.63–1.69; 48-hour PR = 0.89, 95% CI: 0.58–1.38) or 7-day diarrhea prevalence (24-hour PR = 1.17, 95% CI: 0.76–1.78; 48-hour PR = 1.21, 95% CI: 0.81–1.80). The sensitivity, PPV, and NPV of the H2S test was significantly higher when the H2S test was incubated for 48 versus 24 hours whereas specificity showed the opposite trend. H2S test sensitivity, PPV, and NPV increased with increasing E. coli levels, consistent with previous evidence that the H2S test is a useful water quality tool in high-contamination settings. However, our results suggest that the H2S test is not an effective indicator for waterborne diarrhea. PMID:29141754

The INTERLISP Virtual Machine Specification,

DTIC Science & Technology

1976-09-01

typescript ” files. t h i n _ r b is. f i les contain -sung all ofthen i n n _ p m_ n_ b n_ u n _ l~m m : t tm , u i n _ :- , u - n_ h i On s w i t h...nm _ sIn _ c d of a File N~n _ mune ) n_ n _ u u ’J t b - s e nann_e of tb;e current , - typescript file (i f n _ n _ n _ n y). The conrespondunmg f

CD15s/CD62E Interaction Mediates the Adhesion of Non-Small Cell Lung Cancer Cells on Brain Endothelial Cells: Implications for Cerebral Metastasis

PubMed Central

Jassam, Samah A.; Maherally, Zaynah; Ashkan, Keyoumars; Roncaroli, Federico; Fillmore, Helen L.; Pilkington, Geoffrey J.

2017-01-01

Expression of the cell adhesion molecule (CAM), Sialyl Lewis X (CD15s) correlates with cancer metastasis, while expression of E-selectin (CD62E) is stimulated by TNF-α. CD15s/CD62E interaction plays a key role in the homing process of circulating leukocytes. We investigated the heterophilic interaction of CD15s and CD62E in brain metastasis-related cancer cell adhesion. CD15s and CD62E were characterised in human brain endothelium (hCMEC/D3), primary non-small cell lung cancer (NSCLC) (COR-L105 and A549) and metastatic NSCLC (SEBTA-001 and NCI-H1299) using immunocytochemistry, Western blotting, flow cytometry and immunohistochemistry in human brain tissue sections. TNF-α (25 pg/mL) stimulated extracellular expression of CD62E while adhesion assays, under both static and physiological flow live-cell conditions, explored the effect of CD15s-mAb immunoblocking on adhesion of cancer cell–brain endothelium. CD15s was faintly expressed on hCMEC/D3, while high levels were observed on primary NSCLC cells with expression highest on metastatic NSCLC cells (p < 0.001). CD62E was highly expressed on hCMEC/D3 cells activated with TNF-α, with lower levels on primary and metastatic NSCLC cells. CD15s and CD62E were expressed on lung metastatic brain biopsies. CD15s/CD62E interaction was localised at adhesion sites of cancer cell–brain endothelium. CD15s immunoblocking significantly decreased cancer cell adhesion to brain endothelium under static and shear stress conditions (p < 0.001), highlighting the role of CD15s–CD62E interaction in brain metastasis. PMID:28698503

Photothermal Deoxygenation of Graphene Oxide for Distributed Ignition and Patterning Applications (Postprint)

DTIC Science & Technology

2010-01-01

5] B. Brodie, Ann. Chim. Phys. 1855, 45, 351. [6] D. Dikin , S. Stankovich, E. J. Zimney, R. D. Piner, H. B. Dommett, G. Evmenenko, S. T. Nguyen, R. S... Dikin , R. D. Piner, K. A. Kohlhaas, A. Kleinhammes, Y. Jia, Y. Wu, S. T. Nguyen, R. S. Ruoff, Carbon 2007, 45, 1558. [9] S. Stankovich, R. D. Piner, X...Lett. 2007, 7, 3499. [16] S. Stankovich, D. A. Dikin , G. H. B. Dommett, K. M. Kohlhaas, E. J. Zimney, E. A. Stach, R. D. Piner, S. T. Nguyen, R. S

Use of acetic and citric acids to inhibit Escherichia coli O157:H7, Salmonella Typhimurium and Staphylococcus aureus in tabbouleh salad.

PubMed

Al-Rousan, Walid M; Olaimat, Amin N; Osaili, Tareq M; Al-Nabulsi, Anas A; Ajo, Radwan Y; Holley, Richard A

2018-08-01

The objective of the current study was to evaluate the antimicrobial action of different concentrations of acetic (0.3% and 0.4%) or citric (1% and 1.4%) acids and their combinations (1% citric acid plus 0.4% acetic acid and 1.4% citric acid plus 0.3% acetic acid) against Salmonella Typhimurium, Escherichia coli O157:H7 and Staphylococcus aureus in tabbouleh salad stored at 21, 10 and 4 °C. Acetic acid was more inhibitory toward S. Typhimurium and E. coli O157:H7 than citric acid at 21 °C; S. Typhimurium and E. coli O157:H7 cells were not detected in tabbouleh treated with 0.4% acetic acid after 5 and 7 days, respectively. The combined effect of acetic and citric acid was synergistic against S. Typhimurium, and E. coli O157:H7, but not against S. aureus. The combinations of acetic and citric acids reduced S. Typhimurium, and E. coli O157:H7 to below the detection levels after 2 and 3 days at 21 °C, respectively. However, these treatments significantly reduced S. aureus numbers compared to the control at tested temperatures by the end of storage. Acetic and citric acids have the potential to be used in tabbouleh salad to reduce the risk from S. Typhimurium, E. coli O157:H7 and S. aureus. Copyright © 2018. Published by Elsevier Ltd.

The diagnostic value of specific IgE to Ara h 2 to predict peanut allergy in children is comparable to a validated and updated diagnostic prediction model.

PubMed

Klemans, Rob J B; Otte, Dianne; Knol, Mirjam; Knol, Edward F; Meijer, Yolanda; Gmelig-Meyling, Frits H J; Bruijnzeel-Koomen, Carla A F M; Knulst, André C; Pasmans, Suzanne G M A

2013-01-01

A diagnostic prediction model for peanut allergy in children was recently published, using 6 predictors: sex, age, history, skin prick test, peanut specific immunoglobulin E (sIgE), and total IgE minus peanut sIgE. To validate this model and update it by adding allergic rhinitis, atopic dermatitis, and sIgE to peanut components Ara h 1, 2, 3, and 8 as candidate predictors. To develop a new model based only on sIgE to peanut components. Validation was performed by testing discrimination (diagnostic value) with an area under the receiver operating characteristic curve and calibration (agreement between predicted and observed frequencies of peanut allergy) with the Hosmer-Lemeshow test and a calibration plot. The performance of the (updated) models was similarly analyzed. Validation of the model in 100 patients showed good discrimination (88%) but poor calibration (P < .001). In the updating process, age, history, and additional candidate predictors did not significantly increase discrimination, being 94%, and leaving only 4 predictors of the original model: sex, skin prick test, peanut sIgE, and total IgE minus sIgE. When building a model with sIgE to peanut components, Ara h 2 was the only predictor, with a discriminative ability of 90%. Cutoff values with 100% positive and negative predictive values could be calculated for both the updated model and sIgE to Ara h 2. In this way, the outcome of the food challenge could be predicted with 100% accuracy in 59% (updated model) and 50% (Ara h 2) of the patients. Discrimination of the validated model was good; however, calibration was poor. The discriminative ability of Ara h 2 was almost comparable to that of the updated model, containing 4 predictors. With both models, the need for peanut challenges could be reduced by at least 50%. Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

Editing Procedure for Anthropometric Survey Data

DTIC Science & Technology

1978-07-01

prs. lli e er 21 A=S(I,1)/N, B=S(I,2)/N, C=S(I,3)/N, D=S(I,4)/N and, Mean = A + S(I,3) Standard Deviation = /B - A*A Veta I = (C - 3BA + 2A3...Aerospace Medical Research Laboratory (AMRL), Wright-Patterson Air Force Base. The authors wish to extend their thanks to C. E . Clauser, Sandra...W (-> u ɛ CO CT> a X! 0 +J rH C -H (U A! -P M-l • C 0 — •H CO CO u * a; x: QJ 0-.+J .p (0 C 0) — cu E +> TH 6

Molecular Biology of STLV-III and HTLV-IV

DTIC Science & Technology

1990-08-22

8217 AT( ACCA CTCAT.(3CA 5 Ci.T G,- .... ; . , P P, ( L D O S H s v H I -U" G r L "S " V " " , 3 E E 7 ’ T - ’ ’ ’ TJ - " t f? I f T G A- C-. C .T ’ CA8C P...R S N T V K N S D’ . Y S T m 2: G ! Y ’) V V G v I L L R 7 V T Y I’ ,9 M 3: i E F M C f7 E e I V C? iT C? e S . (N*’ 1 . Flist 5At(3CTAGC’’TAATGrAG

Experimental Study on Interactions Between H Atoms and Organic Haze

NASA Technical Reports Server (NTRS)

Sekine, Y.; Imanaka, H.; Khare, B. N.; Bakes, E. L. O.; McKay, C. P.; Sugita, S.; Matsui, T.

2005-01-01

In Titan s atmosphere composed of N2 and CH4, irradiations of both solar ultraviolet light and charged particles induce active chemical reactions. In the processes of these reactions, a large amount of hydrogen (H) atoms are expected to be formed by dissociation of CH4 and other hydrocarbons [e.g., 1, 2]. Theoretical models suggest that these active H atoms need to be converted to stable hydrogen molecules (H2) efficiently to maintain unsaturated hydrocarbons and organic haze in Titan s atmosphere [e.g., 1]. Furthermore, molecular hydrogen is an important greenhouse effect gas in Titan s atmosphere, and small variation in its abundance strongly affects Titan s surface temperature [3]. Thus, the formation of H2 molecules from H atoms is a key reaction for both the atmospheric chemistry and the surface environment of Titan. Although several numerical calculations have been conducted to investigate the atmospheric chemistry of Titan with hypothesized recombination reactions of H atoms, such as catalytic scheme of C4H2 [e.g., 1, 2], it is still unclear what chemical reaction is responsible for the conversion of H atoms to H2 molecules in Titan s atmosphere.

A cloud-evaporation parameterization for general ciculation models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schlesinger, M.E.; Oh, J.H.

1993-04-01

An evaporation-zone (EZ) model for cloud evaporation is developed. In this model a cloud consists of I [open quotes]cloudlets,[close quotes] each comprising cloud droplets with radii from zero to r[sub max], the latter value depending on the drop size distribution (DSD). Evaporation occurs only within the EZ comprised of J[le]I cloudlets. When the cloudlet at cloud edge evaporates, the EZ progresses one cloudlet into the cloud's interior. This eventually results in evaporation of the cloud in time t[sub E] = K(H/h)r[sup 2][sub max](1[minus]S[sub e])[sup [minus]1] where H is the cloud thickness, h the EZ thickness, S[sub e] the environmental saturationmore » ratio, and K a constant. Values of t[sub E](1[minus]S[sub e]) versus h are presented for eight observed DSDs. For use in atmospheric general circulation models (GCMs), the cloud evaporation process is represented by dm/dt=[minus](1[minus]S[sub e])m/[tau], where m is the cloud-water mixing ratio and [tau]=K(H/h)r[sup 2][sub max]n[sup [minus]1]. With parameter n chosen sufficiently large, a GCM cloud will evaporate virtually entirely in time t[sub E], for example, 99.3% for n = 5. Values of [tau] for use in the multilayer atmospheric CRCM have been determined by performing ten perpetual-January simulations and ten perpetual-July simulations, each set of ten for prescribed pairs of [tau] values for stratiform ([tau][sub s]) and cumuloform ([tau][sub c]) clouds. An optimum choice of [tau][sub s] and [tau][sub c], based on minimizing the errors of the model's simulated cloudiness, planetary albedo, outgoing longwave radiation, and precipitation, is [tau][sub s]=[tau][sub c] = 3 min. This corresponds to t[sub E](1-S[sub e]) = 15 min for both stratiform and cumuloform clouds; hence, to an EZ thickness of about 0.6-0.8 m for stratus, stratocumulus, and altostratus clouds, 2-3 m for nimbostratus and cumulus clouds, and 17 m for cumulonimbus clouds. 18 refs., 6 figs.« less

Emily Warren | NREL

Science.gov Websites

generators. Featured Publications Warren, E. L.; Atwater, H. A.; Lewis, N. S. "Silicon Microwire Arrays , (2013) Warren, E. L.; McKone, J. R.; Atwater, H. A.; Gray, H. B.; Lewis, N. S. "Hydrogen-Evolution Characteristics of Ni-Mo-Coated, Radial Junction, n+p-silicon Microwire Array Photocathodes," Energy &

System and process for capture of H.sub.2S from gaseous process streams and process for regeneration of the capture agent

DOEpatents

Heldenbrant, David J; Koech, Phillip K; Rainbolt, James E; Bearden, Mark D; Zheng, Feng

2014-02-18

A system and process are disclosed for selective removal and recovery of H.sub.2S from a gaseous volume, e.g., from natural gas. Anhydrous organic, sorbents chemically capture H.sub.2S gas to form hydrosulfide salts. Regeneration of the capture solvent involves addition of an anti-solvent that releases the captured H.sub.2S gas from the capture sorbent. The capture sorbent and anti-solvent are reactivated for reuse, e.g., by simple distillation.

Use of Spherical Nanoindentation to Characterize the Anisotropic Properties of Microscale Constituents and Interfaces in Hierarchically Structured Composite Materials

DTIC Science & Technology

2015-01-24

Lilleodden, P. Anderson, J.T. Wyrobek, Acta Materialia 44 (1996) 3585-3598. [75] W.W. Gerberich, S. Venkataraman , J. Nelson, H. Huang, E. Lilleodden, W...629-644. [76] W.W. Gerberich, S.K. Venkataraman , H. Huang, S.E. Harvey, D.L. Kohlstedt, Acta Metallurgica et Materialia 43 (1995) 1569. [77] A.E

Thin-Film Optical Switch.

DTIC Science & Technology

1976-09-01

UNCLASSIFIED St Cu* ITY C LA S S I F I C A T I O N OF tIllS PAGE (W~I. , 0.i. Ent.,.~d) REPODT rVW IIMEIITATIAII PACE READ INSTRUCTIONS...MEASUREMENTS 10 A. Ef fec t ive Channel Guide Width 10 13. Rid ge For mation St udies 10 C. Wave guide Loss Measurement s 10 D. Tape r Coup ling Eff...of less coup l ing e f f i c i e n c y at t h e t aper l e n g t h of 900 ~ rn . Ne l son 2 has c o n s i d e r e d the e f f i c i e n c y of

Development of Liposome Encapsulated Hemoglobin (LEH) and Studies of Hemorrhagic Shock by Use of Imaging Studies with Oxygen-15 and Other Radiotracers

DTIC Science & Technology

2004-09-01

hemoglobin in the oxy-hemoglobin state [Stratton 1988; Takeoka 1997]. 3) Decreased Vasoactivity. Because LEH has physical properties closer to red cells...in rabbit arterial segments. J Appl Physiol 82:1826-1835. [21] Sakai H, Horinouchi H, Masada Y, Takeoka S, Ikeda E, Takaori M, Kobayashi K and...4317-4325. [22] Sakai H, Horinouchi H, Tomiyama K, Ikeda E, Takeoka S, Kobayashi K and Tsuchida E (2001) Hemoglobin-vesicles as oxygen carriers

Rational Inhibitors of DNA Base Excision Repair Enzymes: New Tools for Elucidating the Role of BER in Cancer Chemotherapy

DTIC Science & Technology

2006-05-01

2005, 7, 493-500. (30) Nilsen, H.; Rosewell , I.; Robins, P.; Skjelbred, C. F.; Andersen, S.; Slupphaug, G.; Daly, G.; Krokan, H. E.; Lindahl, T.; Barnes...Cell Biol. 2005, 7, 493–500. 31. Nilsen, H.; Rosewell , I.; Robins, P.; Skjelbred, C. F.; Andersen, S.; Slupphaug, G.; Daly, G.; Krokan, H. E

TeV Gamma-Ray Observations of the Binary Neutron Star Merger GW170817 with H.E.S.S.

NASA Astrophysics Data System (ADS)

Abdalla, H.; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Angüner, E. O.; Arakawa, M.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Becker Tjus, J.; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bonnefoy, S.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Capasso, M.; Caroff, S.; Carosi, A.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Colafrancesco, S.; Condon, B.; Conrad, J.; Davids, I. D.; Decock, J.; Deil, C.; Devin, J.; deWilt, P.; Dirson, L.; Djannati-Ataï, A.; Donath, A.; O'C. Drury, L.; Dutson, K.; Dyks, J.; Edwards, T.; Egberts, K.; Emery, G.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Funk, S.; Füssling, M.; Gabici, S.; Gallant, Y. A.; Garrigoux, T.; Gaté, F.; Giavitto, G.; Giebels, B.; Glawion, D.; Glicenstein, J. F.; Gottschall, D.; Grondin, M.-H.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holch, T. L.; Holler, M.; Horns, D.; Ivascenko, A.; Iwasaki, H.; Jacholkowska, A.; Jamrozy, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katsuragawa, M.; Katz, U.; Kerszberg, D.; Khangulyan, D.; Khélifi, B.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Komin, Nu.; Kosack, K.; Krakau, S.; Kraus, M.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Malyshev, D.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morå, K.; Moulin, E.; Murach, T.; Nakashima, S.; de Naurois, M.; Ndiyavala, H.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poireau, V.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Rauth, R.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Rinchiuso, L.; Romoli, C.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Saito, S.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Shiningayamwe, K.; Simoni, R.; Sol, H.; Spanier, F.; Spir-Jacob, M.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Steppa, C.; Sushch, I.; Takahashi, T.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tsirou, M.; Tsuji, N.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zaborov, D.; Zacharias, M.; Zanin, R.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Zorn, J.; Zywucka, N.; H. E. S. S. Collaboration

2017-12-01

We search for high-energy gamma-ray emission from the binary neutron star merger GW170817 with the H.E.S.S. Imaging Air Cherenkov Telescopes. The observations presented here have been obtained starting only 5.3 hr after GW170817. The H.E.S.S. target selection identified regions of high probability to find a counterpart of the gravitational-wave event. The first of these regions contained the counterpart SSS17a that has been identified in the optical range several hours after our observations. We can therefore present the first data obtained by a ground-based pointing instrument on this object. A subsequent monitoring campaign with the H.E.S.S. telescopes extended over several days, covering timescales from 0.22 to 5.2 days and energy ranges between 270 {GeV} to 8.55 {TeV}. No significant gamma-ray emission has been found. The derived upper limits on the very-high-energy gamma-ray flux for the first time constrain non-thermal, high-energy emission following the merger of a confirmed binary neutron star system.

Publications - Plafker, George and Berg, H.C., 1994 | Alaska Division of

Science.gov Websites

, M.S., Smith, T.E., Berg, H.C., Andersen, G.L., Chipp, E.R., Gaard, D.R., Burton, P.J., Dunbler, John ., Newberry, R.J., Rogers, R.K., Rubin, C.M., Swainbank, R.C., Smith, P.R., and Stephens, Jackie, 1994 , H.C., Brew, D.A., Grybeck, Donald, Robinson, M.S., Smith, T.E., and Yeend, Warren, 1994, Metallogenic

H.E.S.S. detection of a strong VHE activity from the blazar 3C 279

NASA Astrophysics Data System (ADS)

Naurois, Mathieu

2018-01-01

H.E.S.S. observations of the flat spectrum radio quasar 3C 279 (redshift z=0.536, R.A.: 12h56m11.1665s, Dec: -05d47m21.523s (J2000)) have been carried out during the past 2 weeks, on the basis of the detection of flaring activity in the gamma-ray band with Fermi-LAT (ATel #11189) and AGILE (ATel #11200), as well as in the optical band (ATels #11190, #11196, #11202, #11216).

Pregnancy Augments VEGF-Stimulated In Vitro Angiogenesis and Vasodilator (NO and H2S) Production in Human Uterine Artery Endothelial Cells.

PubMed

Zhang, Hong-Hai; Chen, Jennifer C; Sheibani, Lili; Lechuga, Thomas J; Chen, Dong-Bao

2017-07-01

Augmented uterine artery (UA) production of vasodilators, including nitric oxide (NO) and hydrogen sulfide (H2S), has been implicated in pregnancy-associated and agonist-stimulated rise in uterine blood flow that is rate-limiting to pregnancy health. Developing a human UA endothelial cell (hUAEC) culture model from main UAs of nonpregnant (NP) and pregnant (P) women for testing a hypothesis that pregnancy augments endothelial NO and H2S production and endothelial reactivity to vascular endothelial growth factor (VEGF). Main UAs from NP and P women were used for developing hUAEC culture models. Comparisons were made between NP- and P-hUAECs in in vitro angiogenesis, activation of cell signaling, expression of endothelial NO synthase (eNOS) and H2S-producing enzymes cystathionine β-synthase (CBS) and cystathionine γ-lyase, and NO/H2S production upon VEGF stimulation. NP- and P-hUAECs displayed a typical cobblestone-like shape in culture and acetylated low-density lipoprotein uptake, stained positively for endothelial and negatively for smooth muscle markers, maintained key signaling proteins during passage, and had statistically significant greater eNOS and CBS proteins in P- vs NP-hUAECs. Treatment with VEGF stimulated in vitro angiogenesis and eNOS protein and NO production only in P-hUEACs and more robust cell signaling in P- vs NP-hUAECs. VEGF stimulated CBS protein expression, accounting for VEGF-stimulated H2S production in hUAECs. Comparisons between NP- and P-hUAECs reveal that pregnancy augments VEGF-stimulated in vitro angiogenesis and NO/H2S production in hUAECs, showing that the newly established hUAEC model provides a critical in vitro tool for understanding human uterine hemodynamics. Copyright © 2017 Endocrine Society

Phase Unwrapping in the Presence of Strong Turbulence

DTIC Science & Technology

2010-03-01

r a t i o n 49 h2=hh( IIndex ) ; 50 hhh =[(h2−de l ta4 ) (h2−de l ta3 ) h2 ( h2+de l ta3 ) ( h2+de l ta4 ) ] ; 51 121 52 f o r index=1:5 53 pha s e sh...i f t= hhh ( index ) ; 54 NonLS phase2 ( : , : , index ) = wrap wave ( w phase /(2∗ pi )−LS phase−pha s e sh i f t ) ; % wrapped waves 55 [ iwc l2...Index ] = min ( iwc l2 ) ; 60 UnwrappedPhase=LS phase+NonLS phase2 ( : , : , I Index ) ; 61 62 h= hhh ( IIndex ) ; % Get phase s h i f t from lowest

Changes in Helicopter Reliability/Maintainability Characteristics Over Time. Volume 2. Data Submitted by Helicopter Manufacturers

DTIC Science & Technology

1975-03-01

Quarterly Evaluation Report [ CH -54A] . . . S. TI. Eighth (8th) Quarterly CH -53 Readiness Report . . .. S-79 *.hrc.e parInation sequences are used In this...Total & Subsystem R Growth Parameters Table 2 CJF-46 Total Aircraft R~ Growth Statiatics Table 5 C7O-46 Subsystem R Growth Statistics Table 5 CH -46...UH-1 Navy. H-2 Navy, *-3 Navy# e OH-6 Army, H-19 Navy, H-19 Army, H-21 Air Force, H-21 Army. H-34 Army, H-34 Navy, H-37 Navy. H-37 Army, H-46 Navy, CH

Navy Nearshore Ocean Prediction Systems

DTIC Science & Technology

2014-09-01

SYSTEMS B Y J AYA R A M V E E R A M O N Y, M A R K D . O R Z E C H , K A C E Y L . E D W A R D S , M I C H A E L G I L L I G A N , J E I K O O...tthor(s) Name(s) (FirstMl est), Code, Afliliation not NR,L / layaram Vet~ramony 7 Mark D 01’%ech 732 Kacey L...Edwards 732{ Michael Gilligan NAVO Eric Terrill Unlv. of CA- Soripp~ rony dePaolo Unlv. of CA. Scripps s intend~ d to offer this paper to the (Nt;~m& of

Horizon geometry for Kerr black holes with synchronized hair

NASA Astrophysics Data System (ADS)

Delgado, Jorge F. M.; Herdeiro, Carlos A. R.; Radu, Eugen

2018-06-01

We study the horizon geometry of Kerr black holes (BHs) with scalar synchronized hair [1], a family of solutions of the Einstein-Klein-Gordon system that continuously connects to vacuum Kerr BHs. We identify the region in parameter space wherein a global isometric embedding in Euclidean 3-space, E3, is possible for the horizon geometry of the hairy BHs. For the Kerr case, such embedding is possible iff the horizon dimensionless spin jH (which equals the total dimensionless spin, j ), the sphericity s and the horizon linear velocity vH are smaller than critical values, j(S ),s(S ),vH(S ), respectively. For the hairy BHs, we find that jH

Population study of Galactic supernova remnants at very high γ-ray energies with H.E.S.S.

NASA Astrophysics Data System (ADS)

H.E.S.S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Angüner, E. O.; Arakawa, M.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Becker Tjus, J.; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bonnefoy, S.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Capasso, M.; Caroff, S.; Carosi, A.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Colafrancesco, S.; Condon, B.; Conrad, J.; Davids, I. D.; Decock, J.; Deil, C.; Devin, J.; deWilt, P.; Dirson, L.; Djannati-Ataï, A.; Donath, A.; Drury, L. O.'C.; Dutson, K.; Dyks, J.; Edwards, T.; Egberts, K.; Emery, G.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Funk, S.; Füßling, M.; Gabici, S.; Gallant, Y. A.; Garrigoux, T.; Gaté, F.; Giavitto, G.; Giebels, B.; Glawion, D.; Glicenstein, J. F.; Gottschall, D.; Grondin, M.-H.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holch, T. L.; Holler, M.; Horns, D.; Ivascenko, A.; Iwasaki, H.; Jacholkowska, A.; Jamrozy, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katsuragawa, M.; Katz, U.; Kerszberg, D.; Khangulyan, D.; Khélifi, B.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Komin, Nu.; Kosack, K.; Krakau, S.; Kraus, M.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Malyshev, D.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morå, K.; Moulin, E.; Murach, T.; Nakashima, S.; de Naurois, M.; Ndiyavala, H.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poireau, V.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Rauth, R.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Rinchiuso, L.; Romoli, C.; Rowell, G.; Rudak, B.; Rulten, C. B.; Safi-Harb, S.; Sahakian, V.; Saito, S.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Shiningayamwe, K.; Simoni, R.; Sol, H.; Spanier, F.; Spir-Jacob, M.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Steppa, C.; Sushch, I.; Takahashi, T.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tsirou, M.; Tsuji, N.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zaborov, D.; Zacharias, M.; Zanin, R.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Zorn, J.; Żywucka, N.

2018-04-01

Shell-type supernova remnants (SNRs) are considered prime candidates for the acceleration of Galactic cosmic rays (CRs) up to the knee of the CR spectrum at E ≈ 3 × 1015 eV. Our Milky Way galaxy hosts more than 350 SNRs discovered at radio wavelengths and at high energies, of which 220 fall into the H.E.S.S. Galactic Plane Survey (HGPS) region. Of those, only 50 SNRs are coincident with a H.E.S.S source and in 8 cases the very high-energy (VHE) emission is firmly identified as an SNR. The H.E.S.S. GPS provides us with a legacy for SNR population study in VHE γ-rays and we use this rich data set to extract VHE flux upper limits from all undetected SNRs. Overall, the derived flux upper limits are not in contradiction with the canonical CR paradigm. Assuming this paradigm holds true, we can constrain typical ambient density values around shell-type SNRs to n ≤ 7 cm-3 and electron-to-proton energy fractions above 10 TeV to ɛep ≤ 5 × 10-3. Furthermore, comparisons of VHE with radio luminosities in non-interacting SNRs reveal a behaviour that is in agreement with the theory of magnetic field amplification at shell-type SNRs.

Population study of Galactic supernova remnants at very high γ -ray energies with H.E.S.S.

DOE PAGES

Abdalla, H.; Abramowski, A.; Aharonian, F.; ...

2018-04-01

Shell-type supernova remnants (SNRs) are considered prime candidates for the acceleration of Galactic cosmic rays (CRs) up to the knee of the CR spectrum at E ≈ 3 × 10 15 eV. Our Milky Way galaxy hosts more than 350 SNRs discovered at radio wavelengths and at high energies, of which 220 fall into the H.E.S.S. Galactic Plane Survey (HGPS) region. Of those, only 50 SNRs are coincident with a H.E.S.S source and in 8 cases the very high-energy (VHE) emission is firmly identified as an SNR. The H.E.S.S. GPS provides us with a legacy for SNR population study inmore » VHE γ-rays and we use this rich data set to extract VHE flux upper limits from all undetected SNRs. Overall, the derived flux upper limits are not in contradiction with the canonical CR paradigm. Assuming this paradigm holds true, we can constrain typical ambient density values around shell-type SNRs to n ≤ 7 cm -3 and electron-to-proton energy fractions above 10 TeV to ϵ ep ≤ 5 × 10 -3. Furthermore, comparisons of VHE with radio luminosities in non-interacting SNRs reveal a behaviour that is in agreement with the theory of magnetic field amplification at shell-type SNRs.« less

Population study of Galactic supernova remnants at very high γ -ray energies with H.E.S.S.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdalla, H.; Abramowski, A.; Aharonian, F.

Shell-type supernova remnants (SNRs) are considered prime candidates for the acceleration of Galactic cosmic rays (CRs) up to the knee of the CR spectrum at E ≈ 3 × 10 15 eV. Our Milky Way galaxy hosts more than 350 SNRs discovered at radio wavelengths and at high energies, of which 220 fall into the H.E.S.S. Galactic Plane Survey (HGPS) region. Of those, only 50 SNRs are coincident with a H.E.S.S source and in 8 cases the very high-energy (VHE) emission is firmly identified as an SNR. The H.E.S.S. GPS provides us with a legacy for SNR population study inmore » VHE γ-rays and we use this rich data set to extract VHE flux upper limits from all undetected SNRs. Overall, the derived flux upper limits are not in contradiction with the canonical CR paradigm. Assuming this paradigm holds true, we can constrain typical ambient density values around shell-type SNRs to n ≤ 7 cm -3 and electron-to-proton energy fractions above 10 TeV to ϵ ep ≤ 5 × 10 -3. Furthermore, comparisons of VHE with radio luminosities in non-interacting SNRs reveal a behaviour that is in agreement with the theory of magnetic field amplification at shell-type SNRs.« less

Are there really no evolutionarily stable strategies in the iterated prisoner's dilemma?

PubMed

Lorberbaum, Jeffrey P; Bohning, Daryl E; Shastri, Ananda; Sine, Lauren E

2002-01-21

The evolutionary form of the iterated prisoner's dilemma (IPD) is a repeated game where players strategically choose whether to cooperate with or exploit opponents and reproduce in proportion to game success. It has been widely used to study the evolution of cooperation among selfish agents. In the past 15 years, researchers proved over a series of papers that there is no evolutionarily stable strategy (ESS) in the IPD when players maintain long-term relationships. This makes it difficult to make predictions about what strategies can actually persist as prevalent in a population over time. Here, we show that this no ESS finding may be a mathematical technicality, relying on implausible players who are "too perfect" in that their probability of cooperating on any move is arbitrarily close to either 0 or 1. Specifically, in the no ESS proof, all strategies were allowed, meaning that after a strategy X experiences any history H, X cooperates with an unrestricted probability p (X, H) where 0< or =p (X, H)< or =1. Here, we restrict strategies to the set S in which X is a member of S [corrected] if after any H, X cooperates with a restricted probability p (X, H) where e< or =p (X, H)< or =1-e and 0

Search for lepton flavour violating decays of the Higgs boson to eτ and eμ in proton-proton collisions at √{ s} = 8 TeV

NASA Astrophysics Data System (ADS)

Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Brondolin, E.; Dragicevic, M.; Erö, J.; Flechl, M.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hartl, C.; Hörmann, N.; Hrubec, J.; Jeitler, M.; Knünz, V.; König, A.; Krammer, M.; Krätschmer, I.; Liko, D.; Matsushita, T.; Mikulec, I.; Rabady, D.; Rahbaran, B.; Rohringer, H.; Schieck, J.; Schöfbeck, R.; Strauss, J.; Treberer-Treberspurg, W.; Waltenberger, W.; Wulz, C.-E.; Mossolov, V.; Shumeiko, N.; Suarez Gonzalez, J.; Alderweireldt, S.; Cornelis, T.; De Wolf, E. A.; Janssen, X.; Knutsson, A.; Lauwers, J.; Luyckx, S.; Van De Klundert, M.; Van Haevermaet, H.; Van Mechelen, P.; Van Remortel, N.; Van Spilbeeck, A.; Abu Zeid, S.; Blekman, F.; D'Hondt, J.; Daci, N.; De Bruyn, I.; Deroover, K.; Heracleous, N.; Keaveney, J.; Lowette, S.; Moreels, L.; Olbrechts, A.; Python, Q.; Strom, D.; Tavernier, S.; Van Doninck, W.; Van Mulders, P.; Van Onsem, G. P.; Van Parijs, I.; Barria, P.; Brun, H.; Caillol, C.; Clerbaux, B.; De Lentdecker, G.; Fasanella, G.; Favart, L.; Grebenyuk, A.; Karapostoli, G.; Lenzi, T.; Léonard, A.; Maerschalk, T.; Marinov, A.; Perniè, L.; Randle-conde, A.; Seva, T.; Vander Velde, C.; Vanlaer, P.; Yonamine, R.; Zenoni, F.; Zhang, F.; Beernaert, K.; Benucci, L.; Cimmino, A.; Crucy, S.; Dobur, D.; Fagot, A.; Garcia, G.; Gul, M.; Mccartin, J.; Ocampo Rios, A. A.; Poyraz, D.; Ryckbosch, D.; Salva, S.; Sigamani, M.; Tytgat, M.; Van Driessche, W.; Yazgan, E.; Zaganidis, N.; Basegmez, S.; Beluffi, C.; Bondu, O.; Brochet, S.; Bruno, G.; Caudron, A.; Ceard, L.; Da Silveira, G. G.; Delaere, C.; Favart, D.; Forthomme, L.; Giammanco, A.; Hollar, J.; Jafari, A.; Jez, P.; Komm, M.; Lemaitre, V.; Mertens, A.; Musich, M.; Nuttens, C.; Perrini, L.; Pin, A.; Piotrzkowski, K.; Popov, A.; Quertenmont, L.; Selvaggi, M.; Vidal Marono, M.; Beliy, N.; Hammad, G. H.; Aldá Júnior, W. L.; Alves, F. L.; Alves, G. A.; Brito, L.; Correa Martins Junior, M.; Hamer, M.; Hensel, C.; Moraes, A.; Pol, M. E.; Rebello Teles, P.; Belchior Batista Das Chagas, E.; Carvalho, W.; Chinellato, J.; Custódio, A.; Da Costa, E. M.; De Jesus Damiao, D.; De Oliveira Martins, C.; Fonseca De Souza, S.; Huertas Guativa, L. M.; Malbouisson, H.; Matos Figueiredo, D.; Mora Herrera, C.; Mundim, L.; Nogima, H.; Prado Da Silva, W. L.; Santoro, A.; Sznajder, A.; Tonelli Manganote, E. J.; Vilela Pereira, A.; Ahuja, S.; Bernardes, C. A.; De Souza Santos, A.; Dogra, S.; Fernandez Perez Tomei, T. R.; Gregores, E. M.; Mercadante, P. G.; Moon, C. S.; Novaes, S. F.; Padula, Sandra S.; Romero Abad, D.; Ruiz Vargas, J. C.; Aleksandrov, A.; Hadjiiska, R.; Iaydjiev, P.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Glushkov, I.; Litov, L.; Pavlov, B.; Petkov, P.; Ahmad, M.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Cheng, T.; Du, R.; Jiang, C. H.; Plestina, R.; Romeo, F.; Shaheen, S. M.; Spiezia, A.; Tao, J.; Wang, C.; Wang, Z.; Zhang, H.; Asawatangtrakuldee, C.; Ban, Y.; Li, Q.; Liu, S.; Mao, Y.; Qian, S. J.; Wang, D.; Xu, Z.; Avila, C.; Cabrera, A.; Chaparro Sierra, L. F.; Florez, C.; Gomez, J. P.; Gomez Moreno, B.; Sanabria, J. C.; Godinovic, N.; Lelas, D.; Puljak, I.; Ribeiro Cipriano, P. M.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Kadija, K.; Luetic, J.; Micanovic, S.; Sudic, L.; Attikis, A.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Rykaczewski, H.; Bodlak, M.; Finger, M.; Finger, M.; Abdelalim, A. A.; Awad, A.; Mahrous, A.; Radi, A.; Calpas, B.; Kadastik, M.; Murumaa, M.; Raidal, M.; Tiko, A.; Veelken, C.; Eerola, P.; Pekkanen, J.; Voutilainen, M.; Härkönen, J.; Karimäki, V.; Kinnunen, R.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Peltola, T.; Tuominen, E.; Tuominiemi, J.; Tuovinen, E.; Wendland, L.; Talvitie, J.; Tuuva, T.; Besancon, M.; Couderc, F.; Dejardin, M.; Denegri, D.; Fabbro, B.; Faure, J. 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A.; Chierici, R.; Contardo, D.; Courbon, B.; Depasse, P.; El Mamouni, H.; Fan, J.; Fay, J.; Gascon, S.; Gouzevitch, M.; Ille, B.; Lagarde, F.; Laktineh, I. B.; Lethuillier, M.; Mirabito, L.; Pequegnot, A. L.; Perries, S.; Ruiz Alvarez, J. D.; Sabes, D.; Sgandurra, L.; Sordini, V.; Vander Donckt, M.; Verdier, P.; Viret, S.; Toriashvili, T.; Tsamalaidze, Z.; Autermann, C.; Beranek, S.; Feld, L.; Heister, A.; Kiesel, M. K.; Klein, K.; Lipinski, M.; Ostapchuk, A.; Preuten, M.; Raupach, F.; Schael, S.; Schulte, J. F.; Verlage, T.; Weber, H.; Zhukov, V.; Ata, M.; Brodski, M.; Dietz-Laursonn, E.; Duchardt, D.; Endres, M.; Erdmann, M.; Erdweg, S.; Esch, T.; Fischer, R.; Güth, A.; Hebbeker, T.; Heidemann, C.; Hoepfner, K.; Knutzen, S.; Kreuzer, P.; Merschmeyer, M.; Meyer, A.; Millet, P.; Olschewski, M.; Padeken, K.; Papacz, P.; Pook, T.; Radziej, M.; Reithler, H.; Rieger, M.; Scheuch, F.; Sonnenschein, L.; Teyssier, D.; Thüer, S.; Cherepanov, V.; Erdogan, Y.; Flügge, G.; Geenen, H.; Geisler, M.; Hoehle, F.; Kargoll, B.; Kress, T.; Kuessel, Y.; Künsken, A.; Lingemann, J.; Nehrkorn, A.; Nowack, A.; Nugent, I. M.; Pistone, C.; Pooth, O.; Stahl, A.; Aldaya Martin, M.; Asin, I.; Bartosik, N.; Behnke, O.; Behrens, U.; Bell, A. J.; Borras, K.; Burgmeier, A.; Campbell, A.; Costanza, F.; Diez Pardos, C.; Dolinska, G.; Dooling, S.; Dorland, T.; Eckerlin, G.; Eckstein, D.; Eichhorn, T.; Flucke, G.; Gallo, E.; Garay Garcia, J.; Geiser, A.; Gizhko, A.; Gunnellini, P.; Hauk, J.; Hempel, M.; Jung, H.; Kalogeropoulos, A.; Karacheban, O.; Kasemann, M.; Katsas, P.; Kieseler, J.; Kleinwort, C.; Korol, I.; Lange, W.; Leonard, J.; Lipka, K.; Lobanov, A.; Lohmann, W.; Mankel, R.; Marfin, I.; Melzer-Pellmann, I.-A.; Meyer, A. B.; Mittag, G.; Mnich, J.; Mussgiller, A.; Naumann-Emme, S.; Nayak, A.; Ntomari, E.; Perrey, H.; Pitzl, D.; Placakyte, R.; Raspereza, A.; Roland, B.; Sahin, M. Ö.; Saxena, P.; Schoerner-Sadenius, T.; Schröder, M.; Seitz, C.; Spannagel, S.; Trippkewitz, K. D.; Walsh, R.; Wissing, C.; Blobel, V.; Centis Vignali, M.; Draeger, A. R.; Erfle, J.; Garutti, E.; Goebel, K.; Gonzalez, D.; Görner, M.; Haller, J.; Hoffmann, M.; Höing, R. S.; Junkes, A.; Klanner, R.; Kogler, R.; Kovalchuk, N.; Lapsien, T.; Lenz, T.; Marchesini, I.; Marconi, D.; Meyer, M.; Nowatschin, D.; Ott, J.; Pantaleo, F.; Peiffer, T.; Perieanu, A.; Pietsch, N.; Poehlsen, J.; Rathjens, D.; Sander, C.; Scharf, C.; Schettler, H.; Schleper, P.; Schlieckau, E.; Schmidt, A.; Schwandt, J.; Sola, V.; Stadie, H.; Steinbrück, G.; Tholen, H.; Troendle, D.; Usai, E.; Vanelderen, L.; Vanhoefer, A.; Vormwald, B.; Barth, C.; Baus, C.; Berger, J.; Böser, C.; Butz, E.; Chwalek, T.; Colombo, F.; De Boer, W.; Descroix, A.; Dierlamm, A.; Fink, S.; Frensch, F.; Friese, R.; Giffels, M.; Gilbert, A.; Haitz, D.; Hartmann, F.; Heindl, S. M.; Husemann, U.; Katkov, I.; Kornmayer, A.; Lobelle Pardo, P.; Maier, B.; Mildner, H.; Mozer, M. U.; Müller, T.; Müller, Th.; Plagge, M.; Quast, G.; Rabbertz, K.; Röcker, S.; Roscher, F.; Sieber, G.; Simonis, H. J.; Stober, F. M.; Ulrich, R.; Wagner-Kuhr, J.; Wayand, S.; Weber, M.; Weiler, T.; Williamson, S.; Wöhrmann, C.; Wolf, R.; Anagnostou, G.; Daskalakis, G.; Geralis, T.; Giakoumopoulou, V. A.; Kyriakis, A.; Loukas, D.; Psallidas, A.; Topsis-Giotis, I.; Agapitos, A.; Kesisoglou, S.; Panagiotou, A.; Saoulidou, N.; Tziaferi, E.; Evangelou, I.; Flouris, G.; Foudas, C.; Kokkas, P.; Loukas, N.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Strologas, J.; Bencze, G.; Hajdu, C.; Hazi, A.; Hidas, P.; Horvath, D.; Sikler, F.; Veszpremi, V.; Vesztergombi, G.; Zsigmond, A. J.; Beni, N.; Czellar, S.; Karancsi, J.; Molnar, J.; Szillasi, Z.; Bartók, M.; Makovec, A.; Raics, P.; Trocsanyi, Z. L.; Ujvari, B.; Choudhury, S.; Mal, P.; Mandal, K.; Sahoo, D. K.; Sahoo, N.; Swain, S. K.; Bansal, S.; Beri, S. B.; Bhatnagar, V.; Chawla, R.; Gupta, R.; Bhawandeep, U.; Kalsi, A. K.; Kaur, A.; Kaur, M.; Kumar, R.; Mehta, A.; Mittal, M.; Singh, J. B.; Walia, G.; Kumar, Ashok; Bhardwaj, A.; Choudhary, B. C.; Garg, R. B.; Kumar, A.; Malhotra, S.; Naimuddin, M.; Nishu, N.; Ranjan, K.; Sharma, R.; Sharma, V.; Bhattacharya, S.; Chatterjee, K.; Dey, S.; Dutta, S.; Jain, Sa.; Majumdar, N.; Modak, A.; Mondal, K.; Mukherjee, S.; Mukhopadhyay, S.; Roy, A.; Roy, D.; Roy Chowdhury, S.; Sarkar, S.; Sharan, M.; Abdulsalam, A.; Chudasama, R.; Dutta, D.; Jha, V.; Kumar, V.; Mohanty, A. K.; Pant, L. M.; Shukla, P.; Topkar, A.; Aziz, T.; Banerjee, S.; Bhowmik, S.; Chatterjee, R. M.; Dewanjee, R. K.; Dugad, S.; Ganguly, S.; Ghosh, S.; Guchait, M.; Gurtu, A.; Kole, G.; Kumar, S.; Mahakud, B.; Maity, M.; Majumder, G.; Mazumdar, K.; Mitra, S.; Mohanty, G. B.; Parida, B.; Sarkar, T.; Sur, N.; Sutar, B.; Wickramage, N.; Chauhan, S.; Dube, S.; Kapoor, A.; Kothekar, K.; Sharma, S.; Bakhshiansohi, H.; Behnamian, H.; Etesami, S. M.; Fahim, A.; Goldouzian, R.; Khakzad, M.; Mohammadi Najafabadi, M.; Naseri, M.; Paktinat Mehdiabadi, S.; Rezaei Hosseinabadi, F.; Safarzadeh, B.; Zeinali, M.; Felcini, M.; Grunewald, M.; Abbrescia, M.; Calabria, C.; Caputo, C.; Colaleo, A.; Creanza, D.; Cristella, L.; De Filippis, N.; De Palma, M.; Fiore, L.; Iaselli, G.; Maggi, G.; Maggi, M.; Miniello, G.; My, S.; Nuzzo, S.; Pompili, A.; Pugliese, G.; Radogna, R.; Ranieri, A.; Selvaggi, G.; Silvestris, L.; Venditti, R.; Verwilligen, P.; Abbiendi, G.; Battilana, C.; Benvenuti, A. C.; Bonacorsi, D.; Braibant-Giacomelli, S.; Brigliadori, L.; Campanini, R.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Chhibra, S. S.; Codispoti, G.; Cuffiani, M.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Fasanella, D.; Giacomelli, P.; Grandi, C.; Guiducci, L.; Marcellini, S.; Masetti, G.; Montanari, A.; Navarria, F. L.; Perrotta, A.; Rossi, A. M.; Rovelli, T.; Siroli, G. P.; Tosi, N.; Travaglini, R.; Cappello, G.; Chiorboli, M.; Costa, S.; Di Mattia, A.; Giordano, F.; Potenza, R.; Tricomi, A.; Tuve, C.; Barbagli, G.; Ciulli, V.; Civinini, C.; D'Alessandro, R.; Focardi, E.; Gori, V.; Lenzi, P.; Meschini, M.; Paoletti, S.; Sguazzoni, G.; Viliani, L.; Benussi, L.; Bianco, S.; Fabbri, F.; Piccolo, D.; Primavera, F.; Calvelli, V.; Ferro, F.; Lo Vetere, M.; Monge, M. R.; Robutti, E.; Tosi, S.; Brianza, L.; Dinardo, M. E.; Fiorendi, S.; Gennai, S.; Gerosa, R.; Ghezzi, A.; Govoni, P.; Malvezzi, S.; Manzoni, R. A.; Marzocchi, B.; Menasce, D.; Moroni, L.; Paganoni, M.; Pedrini, D.; Ragazzi, S.; Redaelli, N.; Tabarelli de Fatis, T.; Buontempo, S.; Cavallo, N.; Di Guida, S.; Esposito, M.; Fabozzi, F.; Iorio, A. O. 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T.; Ligabue, F.; Lomtadze, T.; Martini, L.; Messineo, A.; Palla, F.; Rizzi, A.; Savoy-Navarro, A.; Serban, A. T.; Spagnolo, P.; Tenchini, R.; Tonelli, G.; Venturi, A.; Verdini, P. G.; Barone, L.; Cavallari, F.; D'imperio, G.; Del Re, D.; Diemoz, M.; Gelli, S.; Jorda, C.; Longo, E.; Margaroli, F.; Meridiani, P.; Organtini, G.; Paramatti, R.; Preiato, F.; Rahatlou, S.; Rovelli, C.; Santanastasio, F.; Traczyk, P.; Amapane, N.; Arcidiacono, R.; Argiro, S.; Arneodo, M.; Bellan, R.; Biino, C.; Cartiglia, N.; Costa, M.; Covarelli, R.; Degano, A.; Demaria, N.; Finco, L.; Kiani, B.; Mariotti, C.; Maselli, S.; Migliore, E.; Monaco, V.; Monteil, E.; Obertino, M. M.; Pacher, L.; Pastrone, N.; Pelliccioni, M.; Pinna Angioni, G. L.; Ravera, F.; Romero, A.; Ruspa, M.; Sacchi, R.; Solano, A.; Staiano, A.; Belforte, S.; Candelise, V.; Casarsa, M.; Cossutti, F.; Della Ricca, G.; Gobbo, B.; La Licata, C.; Marone, M.; Schizzi, A.; Zanetti, A.; Kropivnitskaya, A.; Nam, S. K.; Kim, D. H.; Kim, G. N.; Kim, M. S.; Kong, D. J.; Lee, S.; Oh, Y. D.; Sakharov, A.; Son, D. C.; Brochero Cifuentes, J. A.; Kim, H.; Kim, T. J.; Song, S.; Choi, S.; Go, Y.; Gyun, D.; Hong, B.; Kim, H.; Kim, Y.; Lee, B.; Lee, K.; Lee, K. S.; Lee, S.; Park, S. K.; Roh, Y.; Yoo, H. D.; Choi, M.; Kim, H.; Kim, J. H.; Lee, J. S. H.; Park, I. C.; Ryu, G.; Ryu, M. S.; Choi, Y.; Goh, J.; Kim, D.; Kwon, E.; Lee, J.; Yu, I.; Dudenas, V.; Juodagalvis, A.; Vaitkus, J.; Ahmed, I.; Ibrahim, Z. A.; Komaragiri, J. R.; Md Ali, M. A. B.; Mohamad Idris, F.; Wan Abdullah, W. A. T.; Yusli, M. N.; Casimiro Linares, E.; Castilla-Valdez, H.; De La Cruz-Burelo, E.; Heredia-De La Cruz, I.; Hernandez-Almada, A.; Lopez-Fernandez, R.; Sanchez-Hernandez, A.; Carrillo Moreno, S.; Vazquez Valencia, F.; Pedraza, I.; Salazar Ibarguen, H. A.; Morelos Pineda, A.; Krofcheck, D.; Butler, P. H.; Ahmad, A.; Ahmad, M.; Hassan, Q.; Hoorani, H. R.; Khan, W. A.; Khurshid, T.; Shoaib, M.; Bialkowska, H.; Bluj, M.; Boimska, B.; Frueboes, T.; Górski, M.; Kazana, M.; Nawrocki, K.; Romanowska-Rybinska, K.; Szleper, M.; Zalewski, P.; Brona, G.; Bunkowski, K.; Byszuk, A.; Doroba, K.; Kalinowski, A.; Konecki, M.; Krolikowski, J.; Misiura, M.; Olszewski, M.; Walczak, M.; Bargassa, P.; Beirão Da Cruz E Silva, C.; Di Francesco, A.; Faccioli, P.; Ferreira Parracho, P. 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V.; Baskakov, A.; Belyaev, A.; Boos, E.; Dubinin, M.; Dudko, L.; Ershov, A.; Gribushin, A.; Klyukhin, V.; Kodolova, O.; Lokhtin, I.; Myagkov, I.; Obraztsov, S.; Petrushanko, S.; Savrin, V.; Snigirev, A.; Azhgirey, I.; Bayshev, I.; Bitioukov, S.; Kachanov, V.; Kalinin, A.; Konstantinov, D.; Krychkine, V.; Petrov, V.; Ryutin, R.; Sobol, A.; Tourtchanovitch, L.; Troshin, S.; Tyurin, N.; Uzunian, A.; Volkov, A.; Adzic, P.; Cirkovic, P.; Milosevic, J.; Rekovic, V.; Alcaraz Maestre, J.; Calvo, E.; Cerrada, M.; Chamizo Llatas, M.; Colino, N.; De La Cruz, B.; Delgado Peris, A.; Escalante Del Valle, A.; Fernandez Bedoya, C.; Fernández Ramos, J. P.; Flix, J.; Fouz, M. C.; Garcia-Abia, P.; Gonzalez Lopez, O.; Goy Lopez, S.; Hernandez, J. M.; Josa, M. I.; Navarro De Martino, E.; Pérez-Calero Yzquierdo, A.; Puerta Pelayo, J.; Quintario Olmeda, A.; Redondo, I.; Romero, L.; Santaolalla, J.; Soares, M. S.; Albajar, C.; de Trocóniz, J. F.; Missiroli, M.; Moran, D.; Cuevas, J.; Fernandez Menendez, J.; Folgueras, S.; Gonzalez Caballero, I.; Palencia Cortezon, E.; Vizan Garcia, J. M.; Cabrillo, I. J.; Calderon, A.; Castiñeiras De Saa, J. R.; De Castro Manzano, P.; Fernandez, M.; Garcia-Ferrero, J.; Gomez, G.; Lopez Virto, A.; Marco, J.; Marco, R.; Martinez Rivero, C.; Matorras, F.; Piedra Gomez, J.; Rodrigo, T.; Rodríguez-Marrero, A. Y.; Ruiz-Jimeno, A.; Scodellaro, L.; Trevisani, N.; Vila, I.; Vilar Cortabitarte, R.; Abbaneo, D.; Auffray, E.; Auzinger, G.; Bachtis, M.; Baillon, P.; Ball, A. H.; Barney, D.; Benaglia, A.; Bendavid, J.; Benhabib, L.; Benitez, J. F.; Berruti, G. 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V.; Neugebauer, H.; Orfanelli, S.; Orsini, L.; Pape, L.; Perez, E.; Peruzzi, M.; Petrilli, A.; Petrucciani, G.; Pfeiffer, A.; Pierini, M.; Piparo, D.; Racz, A.; Reis, T.; Rolandi, G.; Rovere, M.; Ruan, M.; Sakulin, H.; Schäfer, C.; Schwick, C.; Seidel, M.; Sharma, A.; Silva, P.; Simon, M.; Sphicas, P.; Steggemann, J.; Stieger, B.; Stoye, M.; Takahashi, Y.; Treille, D.; Triossi, A.; Tsirou, A.; Veres, G. I.; Wardle, N.; Wöhri, H. K.; Zagozdzinska, A.; Zeuner, W. D.; Bertl, W.; Deiters, K.; Erdmann, W.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; Kotlinski, D.; Langenegger, U.; Renker, D.; Rohe, T.; Bachmair, F.; Bäni, L.; Bianchini, L.; Casal, B.; Dissertori, G.; Dittmar, M.; Donegà, M.; Eller, P.; Grab, C.; Heidegger, C.; Hits, D.; Hoss, J.; Kasieczka, G.; Lustermann, W.; Mangano, B.; Marionneau, M.; Martinez Ruiz del Arbol, P.; Masciovecchio, M.; Meister, D.; Micheli, F.; Musella, P.; Nessi-Tedaldi, F.; Pandolfi, F.; Pata, J.; Pauss, F.; Perrozzi, L.; Quittnat, M.; Rossini, M.; Schönenberger, M.; Starodumov, A.; Takahashi, M.; Tavolaro, V. R.; Theofilatos, K.; Wallny, R.; Aarrestad, T. K.; Amsler, C.; Caminada, L.; Canelli, M. F.; Chiochia, V.; De Cosa, A.; Galloni, C.; Hinzmann, A.; Hreus, T.; Kilminster, B.; Lange, C.; Ngadiuba, J.; Pinna, D.; Rauco, G.; Robmann, P.; Ronga, F. J.; Salerno, D.; Yang, Y.; Cardaci, M.; Chen, K. H.; Doan, T. H.; Jain, Sh.; Khurana, R.; Konyushikhin, M.; Kuo, C. M.; Lin, W.; Lu, Y. J.; Pozdnyakov, A.; Yu, S. S.; Kumar, Arun; Bartek, R.; Chang, P.; Chang, Y. H.; Chang, Y. 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T.; Derdzinski, M.; Holzner, A.; Kelley, R.; Klein, D.; Letts, J.; Macneill, I.; Olivito, D.; Padhi, S.; Pieri, M.; Sani, M.; Sharma, V.; Simon, S.; Tadel, M.; Vartak, A.; Wasserbaech, S.; Welke, C.; Würthwein, F.; Yagil, A.; Zevi Della Porta, G.; Bradmiller-Feld, J.; Campagnari, C.; Dishaw, A.; Dutta, V.; Flowers, K.; Franco Sevilla, M.; Geffert, P.; George, C.; Golf, F.; Gouskos, L.; Gran, J.; Incandela, J.; Mccoll, N.; Mullin, S. D.; Richman, J.; Stuart, D.; Suarez, I.; West, C.; Yoo, J.; Anderson, D.; Apresyan, A.; Bornheim, A.; Bunn, J.; Chen, Y.; Duarte, J.; Mott, A.; Newman, H. B.; Pena, C.; Spiropulu, M.; Vlimant, J. R.; Xie, S.; Zhu, R. Y.; Andrews, M. B.; Azzolini, V.; Calamba, A.; Carlson, B.; Ferguson, T.; Paulini, M.; Russ, J.; Sun, M.; Vogel, H.; Vorobiev, I.; Cumalat, J. P.; Ford, W. T.; Gaz, A.; Jensen, F.; Johnson, A.; Krohn, M.; Mulholland, T.; Nauenberg, U.; Stenson, K.; Wagner, S. R.; Alexander, J.; Chatterjee, A.; Chaves, J.; Chu, J.; Dittmer, S.; Eggert, N.; Mirman, N.; Nicolas Kaufman, G.; Patterson, J. R.; Rinkevicius, A.; Ryd, A.; Skinnari, L.; Soffi, L.; Sun, W.; Tan, S. M.; Teo, W. D.; Thom, J.; Thompson, J.; Tucker, J.; Weng, Y.; Wittich, P.; Abdullin, S.; Albrow, M.; Apollinari, G.; Banerjee, S.; Bauerdick, L. A. T.; Beretvas, A.; Berryhill, J.; Bhat, P. C.; Bolla, G.; Burkett, K.; Butler, J. N.; Cheung, H. W. K.; Chlebana, F.; Cihangir, S.; Elvira, V. D.; Fisk, I.; Freeman, J.; Gottschalk, E.; Gray, L.; Green, D.; Grünendahl, S.; Gutsche, O.; Hanlon, J.; Hare, D.; Harris, R. M.; Hasegawa, S.; Hirschauer, J.; Hu, Z.; Jayatilaka, B.; Jindariani, S.; Johnson, M.; Joshi, U.; Klima, B.; Kreis, B.; Lammel, S.; Linacre, J.; Lincoln, D.; Lipton, R.; Liu, T.; Lopes De Sá, R.; Lykken, J.; Maeshima, K.; Marraffino, J. M.; Maruyama, S.; Mason, D.; McBride, P.; Merkel, P.; Mishra, K.; Mrenna, S.; Nahn, S.; Newman-Holmes, C.; O'Dell, V.; Pedro, K.; Prokofyev, O.; Rakness, G.; Sexton-Kennedy, E.; Soha, A.; Spalding, W. J.; Spiegel, L.; Strobbe, N.; Taylor, L.; Tkaczyk, S.; Tran, N. V.; Uplegger, L.; Vaandering, E. W.; Vernieri, C.; Verzocchi, M.; Vidal, R.; Weber, H. A.; Whitbeck, A.; Acosta, D.; Avery, P.; Bortignon, P.; Bourilkov, D.; Carnes, A.; Carver, M.; Curry, D.; Das, S.; Field, R. D.; Furic, I. K.; Gleyzer, S. V.; Konigsberg, J.; Korytov, A.; Kotov, K.; Ma, P.; Matchev, K.; Mei, H.; Milenovic, P.; Mitselmakher, G.; Rank, D.; Rossin, R.; Shchutska, L.; Snowball, M.; Sperka, D.; Terentyev, N.; Thomas, L.; Wang, J.; Wang, S.; Yelton, J.; Hewamanage, S.; Linn, S.; Markowitz, P.; Martinez, G.; Rodriguez, J. L.; Ackert, A.; Adams, J. R.; Adams, T.; Askew, A.; Bein, S.; Bochenek, J.; Diamond, B.; Haas, J.; Hagopian, S.; Hagopian, V.; Johnson, K. F.; Khatiwada, A.; Prosper, H.; Weinberg, M.; Baarmand, M. M.; Bhopatkar, V.; Colafranceschi, S.; Hohlmann, M.; Kalakhety, H.; Noonan, D.; Roy, T.; Yumiceva, F.; Adams, M. R.; Apanasevich, L.; Berry, D.; Betts, R. R.; Bucinskaite, I.; Cavanaugh, R.; Evdokimov, O.; Gauthier, L.; Gerber, C. E.; Hofman, D. J.; Kurt, P.; O'Brien, C.; Sandoval Gonzalez, I. D.; Turner, P.; Varelas, N.; Wu, Z.; Zakaria, M.; Bilki, B.; Clarida, W.; Dilsiz, K.; Durgut, S.; Gandrajula, R. P.; Haytmyradov, M.; Khristenko, V.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Moeller, A.; Nachtman, J.; Ogul, H.; Onel, Y.; Ozok, F.; Penzo, A.; Snyder, C.; Tiras, E.; Wetzel, J.; Yi, K.; Anderson, I.; Barnett, B. A.; Blumenfeld, B.; Eminizer, N.; Fehling, D.; Feng, L.; Gritsan, A. V.; Maksimovic, P.; Martin, C.; Osherson, M.; Roskes, J.; Sady, A.; Sarica, U.; Swartz, M.; Xiao, M.; Xin, Y.; You, C.; Baringer, P.; Bean, A.; Benelli, G.; Bruner, C.; Kenny, R. P., III; Majumder, D.; Malek, M.; Murray, M.; Sanders, S.; Stringer, R.; Wang, Q.; Ivanov, A.; Kaadze, K.; Khalil, S.; Makouski, M.; Maravin, Y.; Mohammadi, A.; Saini, L. K.; Skhirtladze, N.; Toda, S.; Lange, D.; Rebassoo, F.; Wright, D.; Anelli, C.; Baden, A.; Baron, O.; Belloni, A.; Calvert, B.; Eno, S. C.; Ferraioli, C.; Gomez, J. A.; Hadley, N. J.; Jabeen, S.; Kellogg, R. G.; Kolberg, T.; Kunkle, J.; Lu, Y.; Mignerey, A. C.; Shin, Y. H.; Skuja, A.; Tonjes, M. B.; Tonwar, S. C.; Apyan, A.; Barbieri, R.; Baty, A.; Bierwagen, K.; Brandt, S.; Busza, W.; Cali, I. A.; Demiragli, Z.; Di Matteo, L.; Gomez Ceballos, G.; Goncharov, M.; Gulhan, D.; Iiyama, Y.; Innocenti, G. M.; Klute, M.; Kovalskyi, D.; Lai, Y. S.; Lee, Y.-J.; Levin, A.; Luckey, P. D.; Marini, A. C.; Mcginn, C.; Mironov, C.; Narayanan, S.; Niu, X.; Paus, C.; Roland, C.; Roland, G.; Salfeld-Nebgen, J.; Stephans, G. S. F.; Sumorok, K.; Varma, M.; Velicanu, D.; Veverka, J.; Wang, J.; Wang, T. W.; Wyslouch, B.; Yang, M.; Zhukova, V.; Dahmes, B.; Evans, A.; Finkel, A.; Gude, A.; Hansen, P.; Kalafut, S.; Kao, S. C.; Klapoetke, K.; Kubota, Y.; Lesko, Z.; Mans, J.; Nourbakhsh, S.; Ruckstuhl, N.; Rusack, R.; Tambe, N.; Turkewitz, J.; Acosta, J. G.; Oliveros, S.; Avdeeva, E.; Bloom, K.; Bose, S.; Claes, D. R.; Dominguez, A.; Fangmeier, C.; Gonzalez Suarez, R.; Kamalieddin, R.; Knowlton, D.; Kravchenko, I.; Meier, F.; Monroy, J.; Ratnikov, F.; Siado, J. E.; Snow, G. R.; Alyari, M.; Dolen, J.; George, J.; Godshalk, A.; Harrington, C.; Iashvili, I.; Kaisen, J.; Kharchilava, A.; Kumar, A.; Rappoccio, S.; Roozbahani, B.; Alverson, G.; Barberis, E.; Baumgartel, D.; Chasco, M.; Hortiangtham, A.; Massironi, A.; Morse, D. M.; Nash, D.; Orimoto, T.; Teixeira De Lima, R.; Trocino, D.; Wang, R.-J.; Wood, D.; Zhang, J.; Hahn, K. A.; Kubik, A.; Low, J. F.; Mucia, N.; Odell, N.; Pollack, B.; Schmitt, M.; Stoynev, S.; Sung, K.; Trovato, M.; Velasco, M.; Brinkerhoff, A.; Dev, N.; Hildreth, M.; Jessop, C.; Karmgard, D. J.; Kellams, N.; Lannon, K.; Marinelli, N.; Meng, F.; Mueller, C.; Musienko, Y.; Planer, M.; Reinsvold, A.; Ruchti, R.; Smith, G.; Taroni, S.; Valls, N.; Wayne, M.; Wolf, M.; Woodard, A.; Antonelli, L.; Brinson, J.; Bylsma, B.; Durkin, L. S.; Flowers, S.; Hart, A.; Hill, C.; Hughes, R.; Ji, W.; Ling, T. Y.; Liu, B.; Luo, W.; Puigh, D.; Rodenburg, M.; Winer, B. L.; Wulsin, H. W.; Driga, O.; Elmer, P.; Hardenbrook, J.; Hebda, P.; Koay, S. A.; Lujan, P.; Marlow, D.; Medvedeva, T.; Mooney, M.; Olsen, J.; Palmer, C.; Piroué, P.; Saka, H.; Stickland, D.; Tully, C.; Zuranski, A.; Malik, S.; Barker, A.; Barnes, V. E.; Benedetti, D.; Bortoletto, D.; Gutay, L.; Jha, M. K.; Jones, M.; Jung, A. W.; Jung, K.; Miller, D. H.; Neumeister, N.; Radburn-Smith, B. C.; Shi, X.; Shipsey, I.; Silvers, D.; Sun, J.; Svyatkovskiy, A.; Wang, F.; Xie, W.; Xu, L.; Parashar, N.; Stupak, J.; Adair, A.; Akgun, B.; Chen, Z.; Ecklund, K. M.; Geurts, F. J. M.; Guilbaud, M.; Li, W.; Michlin, B.; Northup, M.; Padley, B. P.; Redjimi, R.; Roberts, J.; Rorie, J.; Tu, Z.; Zabel, J.; Betchart, B.; Bodek, A.; de Barbaro, P.; Demina, R.; Eshaq, Y.; Ferbel, T.; Galanti, M.; Garcia-Bellido, A.; Han, J.; Harel, A.; Hindrichs, O.; Khukhunaishvili, A.; Petrillo, G.; Tan, P.; Verzetti, M.; Arora, S.; Chou, J. P.; Contreras-Campana, C.; Contreras-Campana, E.; Ferencek, D.; Gershtein, Y.; Gray, R.; Halkiadakis, E.; Hidas, D.; Hughes, E.; Kaplan, S.; Kunnawalkam Elayavalli, R.; Lath, A.; Nash, K.; Panwalkar, S.; Park, M.; Salur, S.; Schnetzer, S.; Sheffield, D.; Somalwar, S.; Stone, R.; Thomas, S.; Thomassen, P.; Walker, M.; Foerster, M.; Riley, G.; Rose, K.; Spanier, S.; Bouhali, O.; Castaneda Hernandez, A.; Celik, A.; Dalchenko, M.; De Mattia, M.; Delgado, A.; Dildick, S.; Eusebi, R.; Gilmore, J.; Huang, T.; Kamon, T.; Krutelyov, V.; Mueller, R.; Osipenkov, I.; Pakhotin, Y.; Patel, R.; Perloff, A.; Rose, A.; Safonov, A.; Tatarinov, A.; Ulmer, K. A.; Akchurin, N.; Cowden, C.; Damgov, J.; Dragoiu, C.; Dudero, P. R.; Faulkner, J.; Kunori, S.; Lamichhane, K.; Lee, S. W.; Libeiro, T.; Undleeb, S.; Volobouev, I.; Appelt, E.; Delannoy, A. G.; Greene, S.; Gurrola, A.; Janjam, R.; Johns, W.; Maguire, C.; Mao, Y.; Melo, A.; Ni, H.; Sheldon, P.; Snook, B.; Tuo, S.; Velkovska, J.; Xu, Q.; Arenton, M. W.; Cox, B.; Francis, B.; Goodell, J.; Hirosky, R.; Ledovskoy, A.; Li, H.; Lin, C.; Neu, C.; Sinthuprasith, T.; Sun, X.; Wang, Y.; Wolfe, E.; Wood, J.; Xia, F.; Clarke, C.; Harr, R.; Karchin, P. E.; Kottachchi Kankanamge Don, C.; Lamichhane, P.; Sturdy, J.; Belknap, D. A.; Carlsmith, D.; Cepeda, M.; Dasu, S.; Dodd, L.; Duric, S.; Gomber, B.; Grothe, M.; Hall-Wilton, R.; Herndon, M.; Hervé, A.; Klabbers, P.; Lanaro, A.; Levine, A.; Long, K.; Loveless, R.; Mohapatra, A.; Ojalvo, I.; Perry, T.; Pierro, G. A.; Polese, G.; Ruggles, T.; Sarangi, T.; Savin, A.; Sharma, A.; Smith, N.; Smith, W. H.; Taylor, D.; Woods, N.; CMS Collaboration

2016-12-01

A direct search for lepton flavour violating decays of the Higgs boson (H) in the H → eτ and H → eμ channels is described. The data sample used in the search was collected in proton-proton collisions at √{ s} = 8 TeV with the CMS detector at the LHC and corresponds to an integrated luminosity of 19.7 fb-1. No evidence is found for lepton flavour violating decays in either final state. Upper limits on the branching fractions, B (H → eτ) < 0.69% and B (H → eμ) < 0.035%, are set at the 95% confidence level. The constraint set on B (H → eτ) is an order of magnitude more stringent than the existing indirect limits. The limits are used to constrain the corresponding flavour violating Yukawa couplings, absent in the standard model.

Feasibility Studies of an Electrochemical Test Method for Nitrogen Tetroxide Compatibility Testing.

DTIC Science & Technology

1978-11-01

I - fl i ght Density Acid ( HDA ) type systems (N204—HNO 3) in order to achieve t r a - s - ~t i r - i h s I e d e...id rich ph a s e w i l l r e s u l t in HDA type nitric acid corrosion in localized , s i t e s ( i . - . , c r e v t s~s , s - t c . ) . E l e

Antibodies Expressed by Intratumoral B Cells as the Basis for a Diagnostic Test for Lung Cancer

DTIC Science & Technology

2015-06-01

Dixon, A., Zhang, R., Walter, E., Parks, R., Whitesides, J., Marshall, D. J., Hwang, K. K., Yang, Y., Chen, X., Gao, F., Munshaw, S., Kepler , T. B...A., Jaeger, F., Donathan, M., Bilska, M., Gray, E. S., Abdool Karim, S. S., Kepler , T. B., Whitesides, J., Montefiori, D., Moody, M. A., Liao, H...A., Alam, S. M., Tomaras, G. D., Kepler , T. B., Kelsoe, G., Liao, H. X., and Haynes, B. F. (2011) H3N2 influenza infection elicits more cross

Super (a*, d*)-ℋ-antimagic total covering of second order of shackle graphs

NASA Astrophysics Data System (ADS)

Hesti Agustin, Ika; Dafik; Nisviasari, Rosanita; Prihandini, R. M.

2017-12-01

Let H be a simple and connected graph. A shackle of graph H, denoted by G = shack(H, v, n), is a graph G constructed by non-trivial graphs H 1, H 2, …, H n such that, for every 1 ≤ s, t ≤ n, H s and Ht have no a common vertex with |s - t| ≥ 2 and for every 1 ≤ i ≤ n - 1, Hi and H i+1 share exactly one common vertex v, called connecting vertex, and those k - 1 connecting vertices are all distinct. The graph G is said to be an (a*, d*)-H-antimagic total graph of second order if there exist a bijective function f : V(G) ∪ E(G) → {1, 2, …, |V(G)| + |E(G)|} such that for all subgraphs isomorphic to H, the total H-weights W(H)=\\displaystyle {\\sum }v\\in V(H)f(v)+\\displaystyle {\\sum }e\\in E(H)f(e) form an arithmetic sequence of second order of \\{a* ,a* +d* ,a* +3d* ,a* +6d* ,\\ldots ,a* +(\\frac{{n}2-n}{2})d* \\}, where a* and d* are positive integers and n is the number of all subgraphs isomorphic to H. An (a*, d*)-H-antimagic total labeling of second order f is called super if the smallest labels appear in the vertices. In this paper, we study a super (a*, d*)-H antimagic total labeling of second order of G = shack(H, v, n) by using a partition technique of second order.

Specific IgE to peanut 2S albumin Ara h 7 has a discriminative ability comparable to Ara h 2 and 6.

PubMed

Blankestijn, M A; Otten, H G; Suer, W; Weimann, A; Knol, E F; Knulst, A C

2018-01-01

Little is known on the clinical relevance of peanut 2S albumin Ara h 7. To investigate the discriminative ability of Ara h 7 in peanut allergy and assess the role of cross-reactivity between Ara h 2, 6 and Ara h 7 isoforms. Sensitization to recombinant peanut storage proteins Ara h 1, 2, 3, 6, and 7 was assessed using a line blot in sera from 40 peanut-tolerant and 40 peanut-allergic patients, based on food challenge outcome. A dose-dependent ELISA inhibition experiment was performed with recombinant Ara h 2, 6 and Ara h 7 isoforms. For Ara h 7.0201, an area under the ROC curve was found of 0.83, comparable to Ara h 2 (AUC 0.81) and Ara h 6 (AUC 0.85). Ara h 7 intensity values strongly correlated with those from Ara h 2 and 6 (r s = 0.81). Of all patients sensitized to 2S albumins Ara h 2, 6, or 7, the majority was co-sensitized to all three (n = 24, 68%), although mono-sensitization to either 2S albumin was also observed in selected patients (Ara h 2: n = 6, 17%; Ara h 6: n = 2, 6%; Ara h 7: n = 2, 6%). Binding to Ara h 7.0101 could be strongly inhibited by Ara h 7.0201, but not the other way around. Specific IgE against Ara h 7.0201 has a predictive ability for peanut allergy similar to Ara h 2 and 6 and possesses unique IgE epitopes as well as epitopes shared between the other Ara h 7 isoform and Ara h 2 and 6. While co-sensitization to all three 2S albumins is most common, mono-sensitization to either Ara h 2, 6, or 7 occurs in selected patients, leading to a risk of misdiagnosis when testing for a single 2S albumin. © 2017 John Wiley & Sons Ltd.

Crystal structure and substrate specificity of the [beta]-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qiu, Xiayang; Choudhry, Anthony E.; Janson, Cheryl A.

{beta}-Ketoacyl-ACP synthase III (FabH), an essential enzyme for bacterial viability, catalyzes the initiation of fatty acid elongation by condensing malonyl-ACP with acetyl-CoA. We have determined the crystal structure of FabH from Staphylococcus aureus, a Gram-positive human pathogen, to 2 {angstrom} resolution. Although the overall structure of S. aureus FabH is similar to that of Escherichia coli FabH, the primer binding pocket in S. aureus FabH is significantly larger than that present in E. coli FabH. The structural differences, which agree with kinetic parameters, provide explanation for the observed varying substrate specificity for E. coli and S. aureus FabH. The rankmore » order of activity of S. aureus FabH with various acyl-CoA primers was as follows: isobutyryl- > hexanoyl- > butyryl- > isovaleryl- >> acetyl-CoA. The availability of crystal structure may aid in designing potent, selective inhibitors of S. aureus FabH.« less

Using fluorescence measurement of zinc ions liberated from ZnS nanoparticle labels in bioassay for Escherichia coli O157:H7

NASA Astrophysics Data System (ADS)

Cowles, Chad L.; Zhu, Xiaoshan; Pai, Chi-Yun

2011-10-01

In this study, an alternative approach using ZnS nanoparticle biolabels as fluorescence signal transducers is reported for the immunoassay of E. coli O157:H7 in tap water samples. Instead of measuring the fluorescence of ZnS nanoparticles in the assay, the fluorescence signal is generated through the binding of zinc ions released from nanoparticle labels with zinc-ion sensitive fluorescence indicator Fluozin-3. In the assay, ZnS nanoparticles around 50 nm in diameter were synthesized, bioconjugated, and applied for the detection of E. coli O157:H7. The assay shows a detection range over two orders of magnitude and a detection limit around 1000 colony-forming units (cfu) of E. coli O157:H7.

The Galactic Center observed with H.E.S.S.

NASA Astrophysics Data System (ADS)

Jouvin, Lea

2017-08-01

The Galactic Center region has been a prime target region for the H.E.S.S. Imaging Atmospheric Cherenkov Telescope Array observations since da ta taking started in 2003. H.E.S.S. has revealed the presence of a very high energy gamma-ray diffuse emission in the central 200 pc, in addition to the detection of a point like source coincident with the supermassive black hole SgrA*. With more than 250 hours of H.E.S.S. data and the continuous improvement of the analysis techniques, a detailed morphology and spectral analysis of the region is now possible. We will report on the new characterisation of the spectrum of the central source down to 100 GeV energies taking advantage of the H.E.S.S. II data, obtained after the inclusion of the large 28-meter CT5 telescope in the array centre. We will present the recent discovery of a powerful cosmic PeVatron accelerator at the center of our Galaxy as well as a new characterization of the diffuse gamma-ray emission in the central 200 pc of our Galaxy through a detailed morphology study. By analysing the nature of the various components of this emission, the existence of a strong cosmic-ray gradient and thus the presence of a strong cosmic-ray accelerator at the very centre of our Galaxy was found. We will also report on the discovery of an additional point-like source HESS J1746-285 in this region possibly associated with the pulsar wind nebula candidate G0.13-0.11.

Cystathionine γ-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure.

PubMed

Szijártó, István András; Markó, Lajos; Filipovic, Milos R; Miljkovic, Jan Lj; Tabeling, Christoph; Tsvetkov, Dmitry; Wang, Ning; Rabelo, Luiza A; Witzenrath, Martin; Diedrich, André; Tank, Jens; Akahoshi, Noriyuki; Kamata, Shotaro; Ishii, Isao; Gollasch, Maik

2018-06-01

Hydrogen sulfide (H 2 S) and NO are important gasotransmitters, but how endogenous H 2 S affects the circulatory system has remained incompletely understood. Here, we show that CTH or CSE (cystathionine γ-lyase)-produced H 2 S scavenges vascular NO and controls its endogenous levels in peripheral arteries, which contribute to blood pressure regulation. Furthermore, eNOS (endothelial NO synthase) and phospho-eNOS protein levels were unaffected, but levels of nitroxyl were low in CTH-deficient arteries, demonstrating reduced direct chemical interaction between H 2 S and NO. Pretreatment of arterial rings from CTH-deficient mice with exogenous H 2 S donor rescued the endothelial vasorelaxant response and decreased tissue NO levels. Our discovery that CTH-produced H 2 S inhibits endogenous endothelial NO bioavailability and vascular tone is novel and fundamentally important for understanding how regulation of vascular tone is tailored for endogenous H 2 S to contribute to systemic blood pressure function. © 2018 American Heart Association, Inc.

TeV Gamma-Ray Observations of the Binary Neutron Star Merger GW170817 with H.E.S.S.

DOE PAGES

Abdalla, H.; Abramowski, A.; Aharonian, F.; ...

2017-11-22

Here, we search for high-energy gamma-ray emission from the binary neutron star merger GW170817 with the H.E.S.S. Imaging Air Cherenkov Telescopes. The observations presented here have been obtained starting only 5.3 hr after GW170817. The H.E.S.S. target selection identified regions of high probability to find a counterpart of the gravitational-wave event. The first of these regions contained the counterpart SSS17a that has been identified in the optical range several hours after our observations. We can therefore present the first data obtained by a ground-based pointing instrument on this object. A subsequent monitoring campaign with the H.E.S.S. telescopes extended over several days, covering timescales from 0.22 to 5.2 days and energy ranges betweenmore » $$270\\,\\mathrm{GeV}$$ to $$8.55\\,\\mathrm{TeV}$$. No significant gamma-ray emission has been found. The derived upper limits on the very-high-energy gamma-ray flux for the first time constrain non-thermal, high-energy emission following the merger of a confirmed binary neutron star system.« less

The upgrade of the H.E.S.S. cameras

NASA Astrophysics Data System (ADS)

Giavitto, Gianluca; Ashton, Terry; Balzer, Arnim; Berge, David; Brun, Francois; Chaminade, Thomas; Delagnes, Eric; Fontaine, Gerard; Füßling, Matthias; Giebels, Berrie; Glicenstein, Jean-Francois; Gräber, Tobias; Hinton, Jim; Jahnke, Albert; Klepser, Stefan; Kossatz, Marko; Kretzschmann, Axel; Lefranc, Valentin; Leich, Holger; Lüdecke, Hartmut; Lypova, Iryna; Manigot, Pascal; Marandon, Vincent; Moulin, Emmanuel; de Naurois, Mathieu; Nayman, Patrick; Ohm, Stefan; Penno, Marek; Ross, Duncan; Salek, David; Schade, Markus; Schwab, Thomas; Simoni, Rachel; Stegmann, Christian; Steppa, Constantin; Thornhill, Julian; Toussnel, Francois

2017-01-01

The High Energy Stereoscopic System (H.E.S.S.) is an array of five imaging atmospheric Cherenkov telescopes (IACT) located in Namibia. In order to assure the continuous operation of H.E.S.S. at its full sensitivity until and possibly beyond the advent of CTA, the older cameras, installed in 2003, are currently undergoing an extensive upgrade. Its goals are reducing the system failure rate, reducing the dead time and improving the overall performance of the array. All camera components have been upgraded, except the mechanical structure and the photo-multiplier tubes (PMTs). Novel technical solutions have been introduced: the upgraded readout electronics is based on the NECTAr analog memory chip; the control of the hardware is carried out by an FPGA coupled to an embedded ARM computer; the control software was re-written from scratch and it is based on modern C++ open source libraries. These hardware and software solutions offer very good performance, robustness and flexibility. The first camera was fielded in July 2015 and has been successfully commissioned; the rest is scheduled to be upgraded in September 2016. The present contribution describes the design, the testing and the performance of the new H.E.S.S. camera and its components.

TeV Gamma-Ray Observations of the Binary Neutron Star Merger GW170817 with H.E.S.S.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdalla, H.; Abramowski, A.; Aharonian, F.

Here, we search for high-energy gamma-ray emission from the binary neutron star merger GW170817 with the H.E.S.S. Imaging Air Cherenkov Telescopes. The observations presented here have been obtained starting only 5.3 hr after GW170817. The H.E.S.S. target selection identified regions of high probability to find a counterpart of the gravitational-wave event. The first of these regions contained the counterpart SSS17a that has been identified in the optical range several hours after our observations. We can therefore present the first data obtained by a ground-based pointing instrument on this object. A subsequent monitoring campaign with the H.E.S.S. telescopes extended over several days, covering timescales from 0.22 to 5.2 days and energy ranges betweenmore » $$270\\,\\mathrm{GeV}$$ to $$8.55\\,\\mathrm{TeV}$$. No significant gamma-ray emission has been found. The derived upper limits on the very-high-energy gamma-ray flux for the first time constrain non-thermal, high-energy emission following the merger of a confirmed binary neutron star system.« less

Role of Stat3 and ErbB2 in Breast Cancer

DTIC Science & Technology

2011-10-01

Cell. Biol. 29 (2009) 1796–1813. [29] M. Kohler, S. Ansieau, S. Prehn , A. Leutz, H. Haller, E. Hartmann, Cloning of two novel human importin-alpha...Christiansen, F.R. Bischoff, S. Prehn ,H.Haller, D. Gorlich, E. Hartmann, Evidence for distinct substrate specificities of importin alpha family members in

Interferon Antagonism as a Common Virulence Factor of Hemorrhagic Fever Viruses

DTIC Science & Technology

2009-02-01

pathogenesis. Proc Soc Exp Biol Med 223:241-57. 11. Kohler, M., S. Ansieau, S. Prehn , A. Leutz, H. Haller, and E. Hartmann. 1997. Cloning of two novel human...Christiansen, F. R. Bischoff, S. Prehn , H. Haller, D. Gorlich, and E. Hartmann. 1999. Evidence for distinct substrate specificities of importin

The Design Implementation of an Operational, Computer Based Weather Radar System,

DTIC Science & Technology

1979-01-01

AN OPERATIONAL, COMPUTER-BASED WEATHER RADAR SYSTEM Authors: A P Ball, J L Clarke, M J O’Brien A H Shaw , S E Trigg and T A Voller ’Original contains...A ’Ball, J L/Clarke, MJ/O’Brien A H , Shaw , S E Trigg and T A Voller SUMMARY Inis memorand,,m describes the work of the RSRE Weather Radar Division in...IMPLEMENTATION OF AN OPERATIONAL, COMPUTER BASED WEATHER RADAR SYSTEM A P Ball, J L Clarke, M J O’Brien, A H Shaw , S E Trigg and T A Voller CONTENTS 1

Inhibition of /sup 3/H-leukotriene D4 binding to guinea pig lung receptors by the novel leukotriene antagonist ICI 198,615

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aharony, D.; Falcone, R.C.; Krell, R.D.

1987-12-01

The specific binding of (/sup 3/H)5(S)hydroxy-6(R)-S-cysteinylglycyl -7(E),9(E),11(Z),14(Z)-eicosatetraenoic acid ((/sup 3/H)LTD4) to receptors on guinea pig lung parenchymal membranes and its inhibition by ICI 198,615, a representative example of a new class of leukotriene antagonists, was characterized by a receptor-ligand binding assay. (/sup 3/H)LTD4 bound specifically and rapidly (Kon = 0.29 +/- 0.6 nM-1.min-1) reaching equilibrium within 15 min. The rate of binding was greatly inhibited in the presence of ICI 198,615. Excess LTD4 or ICI 198,615 slowly (t1/2 = 20 min) dissociated about 70% of the receptor-bound (/sup 3/H)LTD4, whereas in combination with GTP analogs, both induced a rapid (t1/2more » less than 5 min) and full dissociation. Equilibrium saturation analysis of (/sup 3/H)LTD4 binding demonstrated a saturable (Bmax = 1014 +/- 174 fmol/mg) and high affinity (Kd = 0.43 +/- 0.09 nM) binding site. A high degree of stereoselectivity was demonstrated with inhibition of binding by the stereoisomers of LTD4: S,R much greater than R,R greater than R,S much greater than S,S. The rank order for inhibition of binding by peptide leukotriene was: LTD4 greater than 5(S)-hydroxy-6(R)-S-cysteinyl-7(E),9(E),11(Z),14(Z)-eicosatetraenoic acid much greater than 5(S)hydroxy-6(R)-S-glutathionyl-7(E),9(E),11(Z),14(Z)-eicosatetraenoic acid (potency ratios were: 1:4:590). In competition assays, ICI 198,615 competitively inhibited binding of (/sup 3/H)LTD4 (Ki = 0.27 +/- 0.16 nM) and was 2300-fold and 3100-fold more potent than LY171883 or FPL55712. These data, together with results obtained previously in functional receptor assays, illustrate that this new class of leukotriene antagonists are the most potent and selective competitive antagonists of LTD4 receptors yet described.« less

Salmonella enterica suppresses Pectobacterium carotovorum subsp. carotovorum population and soft rot progression by acidifying the microaerophilic environment.

PubMed

Kwan, Grace; Charkowski, Amy O; Barak, Jeri D

2013-02-12

Although enteric human pathogens are usually studied in the context of their animal hosts, a significant portion of their life cycle occurs on plants. Plant disease alters the phyllosphere, leading to enhanced growth of human pathogens; however, the impact of human pathogens on phytopathogen biology and plant health is largely unknown. To characterize the interaction between human pathogens and phytobacterial pathogens in the phyllosphere, we examined the interactions between Pectobacterium carotovorum subsp. carotovorum and Salmonella enterica or Escherichia coli O157:H7 with regard to bacterial populations, soft rot progression, and changes in local pH. The presence of P. carotovorum subsp. carotovorum enhanced the growth of both S. enterica and E. coli O157:H7 on leaves. However, in a microaerophilic environment, S. enterica reduced P. carotovorum subsp. carotovorum populations and soft rot progression by moderating local environmental pH. Reduced soft rot was not due to S. enterica proteolytic activity. Limitations on P. carotovorum subsp. carotovorum growth, disease progression, and pH elevation were not observed on leaves coinoculated with E. coli O157:H7 or when leaves were coinoculated with S. enterica in an aerobic environment. S. enterica also severely undermined the relationship between the phytobacterial population and disease progression of a P. carotovorum subsp. carotovorum budB mutant defective in the 2,3-butanediol pathway for acid neutralization. Our results show that S. enterica and E. coli O157:H7 interact differently with the enteric phytobacterial pathogen P. carotovorum subsp. carotovorum. S. enterica inhibition of soft rot progression may conceal a rapidly growing human pathogen population. Whereas soft rotted produce can alert consumers to the possibility of food-borne pathogens, healthy-looking produce may entice consumption of contaminated vegetables. Salmonella enterica and Escherichia coli O157:H7 may use plants to move between animal and human hosts. Their populations are higher on plants cocolonized with the common bacterial soft rot pathogen Pectobacterium carotovorum subsp. carotovorum, turning edible plants into a risk factor for human disease. We inoculated leaves with P. carotovorum subsp. carotovorum and S. enterica or E. coli O157:H7 to study the interactions between these bacteria. While P. carotovorum subsp. carotovorum enhanced the growth of both S. enterica and E. coli O157:H7, these human pathogens affected P. carotovorum subsp. carotovorum fundamentally differently. S. enterica reduced P. carotovorum subsp. carotovorum growth and acidified the environment, leading to less soft rot on leaves; E. coli O157:H7 had no such effects. As soft rot signals a food safety risk, the reduction of soft rot symptoms in the presence of S. enterica may lead consumers to eat healthy-looking but S. enterica-contaminated produce.

77 FR 3590 - Registration of Swap Dealers and Major Swap Participants; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-25

...--REGISTRATION Sec. 3.1 [Corrected] 0 2. On page 2626 in the left column, in Sec. 3.1 Definitions, in paragraph (f), ``4s(e), 4s(f), 4s(h), 4s(i), 4s(j), 4s(k) or 4s(l) of the Act.'' is corrected to read ``4s(e), 4s(f), 4s(g), 4s(h), 4s(i), 4s(j), 4s(k) or 4s(l) of the Act.'' PART 23--[CORRECTED] 0 3. On page...

Ara h 2 and Ara 6 are the best predictors of severe peanut allergy: a double-blind placebo-controlled study.

PubMed

Kukkonen, A K; Pelkonen, A S; Mäkinen-Kiljunen, S; Voutilainen, H; Mäkelä, M J

2015-10-01

Component-resolved diagnostics offers a modern tool in peanut allergy, but studies applying consistently double-blind placebo-controlled challenges are lacking. We aimed to optimize diagnostics for moderate-to-severe peanut allergy in a birch-endemic region and to create an oral-peanut challenge with its allergen activity characterized. We performed double-blind placebo-controlled peanut challenges for a referred sample of 6- to 18-year-olds with peanut sensitization or a high suspicion of peanut allergy, including anaphylaxis. We measured specific IgE (sIgE) to Ara h 1, 2, 3, 6, 8, and 9. Testing of allergen activity of the challenge products was by IgE microarray inhibition. Of the 102 patients, 69 were challenge positive: 25 (36%) had severe, 36 (52%) moderate, and 8 (12%) mild symptoms; 38 (37%) received adrenalin. SIgE to Ara h 6 AUC 0.98 (95%CI, 0.96-1.00) was the best marker of moderate-to-severe allergy. When sIgE to Ara h 2 and Ara h 6 was measured together, all (100%) severe reactions at low doses were successfully diagnosable. SIgE to Ara h 8 had no diagnostic value, AUC 0.42 (95%CI, 0.30-0.52). Both nonroasted and roasted peanut inhibited 100% of IgE binding to Ara h 1, 2, 3, and 6. Nonroasted peanut inhibited 87% of IgE binding to Ara h 8, roasted inhibited 30%. The products lacked Ara h 9 activity. Co-sensitization to Ara h 2 and Ara h 6 was associated with severe reactions distinguishing severe allergy from mild symptoms. SIgE to Ara h 8 added no diagnostic value. Component-resolved diagnostics reduce the need for oral challenges in peanut allergy. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

A Manual for the Prediction of Blast and Fragment Loadings on Structures

DTIC Science & Technology

1981-08-15

ives , assembles exp los ives components i n t o assemblies , does more i n s p e c t i o n s , and f i n a l l y packages and s h i p s t h...4100, Los Alamos S c i e n t i f i c Laboratory, Un ive r s i ty of C a l i f o r n i a , Los Alamos , New Mexico, February 1970. 4.29 " I n t e...Massachusetts I n s t i t u t e of Technology, 1976. B- 7 Bdzi l , J. B. and Davis, W. C., "Time-Dependent Detonat ions," J.A-5926-MS, Los Alamos S c i

Evidence for the η(b)(2S) and observation of h(b)(1P)→η(b)(1S)γ and h(b)(2P)→η(b)(1S)γ.

PubMed

Mizuk, R; Asner, D M; Bondar, A; Pedlar, T K; Adachi, I; Aihara, H; Arinstein, K; Aulchenko, V; Aushev, T; Aziz, T; Bakich, A M; Bay, A; Belous, K; Bhardwaj, V; Bhuyan, B; Bischofberger, M; Bonvicini, G; Bozek, A; Bračko, M; Brodzicka, J; Browder, T E; Chekelian, V; Chen, A; Chen, P; Cheon, B G; Chilikin, K; Chistov, R; Cho, I-S; Cho, K; Choi, S-K; Choi, Y; Dalseno, J; Danilov, M; Doležal, Z; Drásal, Z; Drutskoy, A; Eidelman, S; Epifanov, D; Fast, J E; Gaur, V; Gabyshev, N; Garmash, A; Golob, B; Haba, J; Hara, T; Hayasaka, K; Hayashii, H; Horii, Y; Hoshi, Y; Hou, W-S; Hsiung, Y B; Hyun, H J; Iijima, T; Ishikawa, A; Itoh, R; Iwabuchi, M; Iwasaki, Y; Iwashita, T; Jaegle, I; Julius, T; Kang, J H; Kapusta, P; Kawasaki, T; Kim, H J; Kim, H O; Kim, J H; Kim, K T; Kim, M J; Kim, Y J; Kinoshita, K; Ko, B R; Koblitz, S; Kodyš, P; Korpar, S; Kouzes, R T; Križan, P; Krokovny, P; Kuhr, T; Kumita, T; Kuzmin, A; Kwon, Y-J; Lange, J S; Lee, S-H; Li, J; Libby, J; Liu, C; Liu, Y; Liu, Z Q; Liventsev, D; Louvot, R; Matvienko, D; McOnie, S; Miyabayashi, K; Miyata, H; Mohanty, G B; Mohapatra, D; Moll, A; Muramatsu, N; Mussa, R; Nakao, M; Natkaniec, Z; Ng, C; Nishida, S; Nishimura, K; Nitoh, O; Nozaki, T; Ohshima, T; Okuno, S; Olsen, S L; Onuki, Y; Pakhlov, P; Pakhlova, G; Park, C W; Park, H; Pestotnik, R; Petrič, M; Piilonen, L E; Poluektov, A; Röhrken, M; Sakai, Y; Sandilya, S; Santel, D; Sanuki, T; Sato, Y; Schneider, O; Schwanda, C; Senyo, K; Seon, O; Sevior, M E; Shapkin, M; Shen, C P; Shibata, T-A; Shiu, J-G; Shwartz, B; Sibidanov, A; Simon, F; Smerkol, P; Sohn, Y-S; Sokolov, A; Solovieva, E; Stanič, S; Starič, M; Sumihama, M; Sumiyoshi, T; Tanida, K; Tatishvili, G; Teramoto, Y; Tikhomirov, I; Trabelsi, K; Tsuboyama, T; Uchida, M; Uehara, S; Uglov, T; Unno, Y; Uno, S; Vanhoefer, P; Varner, G; Varvell, K E; Vinokurova, A; Vorobyev, V; Wang, C H; Wang, M-Z; Wang, P; Wang, X L; Watanabe, M; Watanabe, Y; Williams, K M; Won, E; Yabsley, B D; Yamaoka, J; Yamashita, Y; Yuan, C Z; Zhang, Z P; Zhilich, V

2012-12-07

We report the first evidence for the η(b)(2S) using the h(b)(2P)→η(b)(2S)γ transition and the first observation of the h(b)(1P)→η(b)(1S)γ and h(b)(2P)→η(b)(1S)γ transitions. The mass and width of the η(b)(1S) and η(b)(2S) are measured to be m(η(b)(1S))=(9402.4±1.5±1.8) MeV/c(2), m(η(b)(2S))=(9999.0±3.5(-1.9)(+2.8)) MeV/c(2), and Γ(η(b)(1S))=(10.8(-3.7-2.0)(+4.0+4.5)) MeV. We also update the h(b)(1P) and h(b)(2P) mass measurements. We use a 133.4 fb(-1) data sample collected at energies near the Υ(5S) resonance with the Belle detector at the KEKB asymmetric-energy e(+)e(-) collider.

Super (a, d)-Cycle-Antimagic Total Labeling on Triangular Ladder Graph and Generalized Jahangir Graph

NASA Astrophysics Data System (ADS)

Roswitha, Mania; Amanda, Anna; Sri Martini, Titin; Winarno, Bowo

2017-06-01

Let G(V (G), E(G)) be a finite simple graph with |V (G)| = G and |E(G)| = eG . Let H be a subgraph of G. The graph G is said to be (a, d)-H-antimagic covering if every edge in G belongs to at least one of the subgraphs G isomorphic to H and there is a bijective function ξ : V ∪ E → {1, 2, …,νG + eG } such that all subgraphs H‧ isomorphic to H, the H‧ -weights w(H‧)=∑v∈V(H‧)ξ(v)+∑e∈E(H‧)ξ(e) constitutes an arithmetic progression {a, a + d, a + 2d, …, a + (t - 1)d}, where a and d are positive integers and t is the number of subgraphs G isomorphic to H. Such a labeling is called super if the vertices contain the smallest possible labels. This research provides super (a, d)-C 3-antimagic total labelng on triangular ladder TLn for n ≥ 2 and super (a, d)-C s+2-antimagic total labeling on generalized Jahangir Jk,s for k ≥ 2 and s ≥ 2.

Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

PubMed Central

Zhou, Qian; Liu, Chunxiao; Liu, Wen; Zhang, Hai; Zhang, Ruijie; Liu, Jia; Zhang, Jinfei; Xu, Chong; Liu, Lei; Huang, Shile; Chen, Long

2015-01-01

Rotenone, a common pesticide and inhibitor of mitochondrial complex I, induces loss of dopaminergic neurons and consequential aspects of Parkinson’s disease (PD). However, the exact mechanism of rotenone neurotoxicity is not fully elucidated. Here, we show that rotenone induced reactive oxygen species (ROS), leading to apoptotic cell death in PC12 cells and primary neurons. Pretreatment with catalase (CAT), a hydrogen peroxide-scavenging enzyme, attenuated rotenone-induced ROS and neuronal apoptosis, implying hydrogen peroxide (H2O2) involved, which was further verified by imaging intracellular H2O2 using a peroxide-selective probe H2DCFDA. Using thenoyltrifluoroacetone (TTFA), antimycin A, or Mito-TEMPO, we further demonstrated rotenone-induced mitochondrial H2O2-dependent neuronal apoptosis. Rotenone dramatically inhibited mTOR-mediated phosphorylation of S6K1 and 4E-BP1, which was also attenuated by CAT in the neuronal cells. Of interest, ectopic expression of wild-type mTOR or constitutively active S6K1, or downregulation of 4E-BP1 partially prevented rotenone-induced H2O2 and cell apoptosis. Furthermore, we noticed that rotenone-induced H2O2 was linked to the activation of caspase-3 pathway. This was evidenced by the finding that pretreatment with CAT partially blocked rotenone-induced cleavages of caspase-3 and poly (ADP-ribose) polymerase. Of note, zVAD-fmk, a pan caspase inhibitor, only partially prevented rotenone-induced apoptosis in PC12 cells and primary neurons. Expression of mTOR-wt, S6K1-ca, or silencing 4E-BP1 potentiated zVAD-fmk protection against rotenone-induced apoptosis in the cells. The results indicate that rotenone induction of H2O2 inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, resulting in caspase-dependent and -independent apoptosis in neuronal cells. Our findings suggest that rotenone-induced neuronal loss in PD may be prevented by activating mTOR signaling and/or administering antioxidants. PMID:25304210

Structure of a human cap-dependent 48S translation pre-initiation complex

PubMed Central

Eliseev, Boris; Yeramala, Lahari; Leitner, Alexander; Karuppasamy, Manikandan; Raimondeau, Etienne; Huard, Karine; Alkalaeva, Elena; Aebersold, Ruedi

2018-01-01

Abstract Eukaryotic translation initiation is tightly regulated, requiring a set of conserved initiation factors (eIFs). Translation of a capped mRNA depends on the trimeric eIF4F complex and eIF4B to load the mRNA onto the 43S pre-initiation complex comprising 40S and initiation factors 1, 1A, 2, 3 and 5 as well as initiator-tRNA. Binding of the mRNA is followed by mRNA scanning in the 48S pre-initiation complex, until a start codon is recognised. Here, we use a reconstituted system to prepare human 48S complexes assembled on capped mRNA in the presence of eIF4B and eIF4F. The highly purified h-48S complexes are used for cross-linking/mass spectrometry, revealing the protein interaction network in this complex. We report the electron cryo-microscopy structure of the h-48S complex at 6.3 Å resolution. While the majority of eIF4B and eIF4F appear to be flexible with respect to the ribosome, additional density is detected at the entrance of the 40S mRNA channel which we attribute to the RNA-recognition motif of eIF4B. The eight core subunits of eIF3 are bound at the 40S solvent-exposed side, as well as the subunits eIF3d, eIF3b and eIF3i. elF2 and initiator-tRNA bound to the start codon are present at the 40S intersubunit side. This cryo-EM structure represents a molecular snap-shot revealing the h-48S complex following start codon recognition. PMID:29401259

Escherichia coli serotype O157:H7 retention on solid surfaces and peroxide resistance is enhanced by dual-strain biofilm formation.

PubMed

Uhlich, Gaylen A; Rogers, Donna P; Mosier, Derek A

2010-08-01

In a previous study we showed that an Escherichia coli O157:H7 strain that was unable to form biofilm was retained in large numbers in dual-strain biofilms formed with an E. coli O-:H4 companion strain. In this study we tested additional companion strains for their ability to retain E. coli O157:H7 strain 0475s. Companion strains producing biofilm that withstood aggressive washes were able to significantly increase serotype O157:H7 retention. Dual-strain biofilms with certain companion strains retained higher percentages of strain 0475s, and that ability was independent of biofilm total cell numbers. Tests with additional non-biofilm-forming E. coli O157:H7 strains showed that enhancement by companion strains was not unique to strain 0475s. Experiments using an E. coli companion strain with deletions of various curli and cellulose genes indicated that dual-strain biofilm formation was dependent on companion strain properties. Strain 0475s was not able to generate biofilm or persist on plastic when grown in broth with a biofilm-forming companion and separated by a 0.2 microm porous membrane, indicating a requirement for intimate contact with the companion strain. When dual-strain biofilms and planktonic cells were challenged with 5% H(2)O(2), strain 0475 showed greater survival in biofilms with certain companion strains compared to the corresponding planktonic cells. The results of this study indicate that non-biofilm-forming E. coli O157:H7 strains are retained on solid surfaces associated with biofilms generated by companion strains. However, properties other than biofilm mass enable certain companion strains to retain greater numbers of E. coli O157:H7.

The Operational Equations of State, 4: The Dulong-Petit Equation of State for Hydrocode

DTIC Science & Technology

2012-07-01

1 1 , 2 2 ln T T T T V S S V S V S HHC C H V V E S V C C E E P VdE E E V d e CT e d V CT...71. 9. Grinfeld, M. A. Thermodynamic Methods in the Theory of Heterogeneous Systems , Longman, New York, 1991. NO. OF COPIES ORGANIZATION

Solid State Research, 1975:3

DTIC Science & Technology

1975-08-15

Heckscher T. F. Deutsch H. Kildal D. L. Spears I. Melngailis T. C. Haiman P. L. Kelley R. S. Eng D. L. Spears H. R. Fetterman H. R... Fetterman H. R. Schlossberg* W. E. Barch 1975 International IEEE/APS Symposium and USNC/URSI Meeting, Urbana, Illinois, 4 June 1975 * Author not...ft. Chinn, S. R. Del-eo, ft. E. Deutsch, T. F. Fetterman , II. R. Hancock, R. C. II. Ileckscher, Kildal, II. Larsen, D. M. Mandel, P

Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones as novel anti-MRSA agents: synthesis, SAR, and in-vitro assessment.

PubMed

Diwakar, Santosh D; Bhagwat, Sachin S; Shingare, Murlidhar S; Gill, Charansing H

2008-08-15

In search for a new antibacterial agent with improved antimicrobial spectrum and potency, we designed and synthesized a series of novel 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones 7a-h by convergent synthesis approach. All the synthesized compounds were assayed for their in-vitro antibacterial activities against gram-negative and gram-positive bacteria. The preliminary structure-activity relationship, to elucidate the essential structure requirements for the antimicrobial activity that results into anti-MRSA (methicillin-resistant S. aureus) potential, has been described. Amongst the synthesized compounds 7d, 7e, 7f and 7h were found to possess activity against methicillin-resistant S. aureus in addition to the activity against other bacterial strains such as E. faecalis, S. pneumoniae, and E. coli.

Software Process Modeling and Execution within Virtual Environments

DTIC Science & Technology

1997-08-01

LhFEX@nOHX@nOe+L X@L X[Lhq³AKe.?HWLvJ&%HV,=>brP"sK\\QehJQFK\\QH�X@nOehJQuUJQehJQHWLe.=�RaHnX>V.VhJQHWY�=@seR³ qwe .?H"L.X>PH?³sP[X>ApX>SUHA...HWLhe.HWYðR³ qwe .?H"YKHWL.nOVhJQFehJQ=@Aº=>bX>VoehJcb X@nOeOLiX>RE=>u@H@IÛe.?H?KsP�X>AºX>S@HAKe+LJQAºe.?HFV.=nOHWL.LX>V.HV.HFV.H� LhH...EX@LiLhsReOX@LhGLCr�’?H ÊUÇ�ÅÄWÀEÕUÄ+Õ,Lhe+Xke.HYUJMY A=@e,nO=@V.V.HWLlFE=@AEY�e.=�XkA³ qwe +XULhGÙIX>AEY�Lh=JQe,giX@L’VoHP=>u@HWYC

Realization of New and Enhanced Materials Properties Through Nanostructural Control

DTIC Science & Technology

2006-05-15

34 Proc. SPIE, 6014, 60140P-1-15 (2005). 57. C. Zhang, S. S. Sun, C. E. Bonner, S. Kim, H. R. Fetterman , and L. R. Dalton, "Polymer Materials for...Wang, J. Zhu, M. He, Y. Ra, S. S. H. Mao, A. W. Harper, L. R. Dalton, and H. R. Fetterman , "Low Vn High Thermal Stability Electro Optic Polymer...H. Zhang, S. M. Garner, S. S. Lee, W. H. Steier, J. Chen, F. Wang, J. Zhu, M. He, Y. Ra, S. S. Mao, A. W. Harper, L. R. Dalton, and H. R. Fetterman

The ST131 Escherichia coli H22 subclone from human intestinal microbiota: Comparison of genomic and phenotypic traits with those of the globally successful H30 subclone.

PubMed

Nicolas-Chanoine, Marie-Hélène; Petitjean, Marie; Mora, Azucena; Mayer, Noémie; Lavigne, Jean-Philippe; Boulet, Olivier; Leflon-Guibout, Véronique; Blanco, Jorge; Hocquet, Didier

2017-03-27

In 2006, we found healthy subjects carrying ST131 Escherichia coli in their intestinal microbiota consisting of two populations: a subdominant population of fluoroquinolone-resistant E. coli belonging to subclone H30 (H30-R or subclade C1), the current worldwide dominant ST131 subclone, and a dominant E. coli population composed of antibiotic-susceptible E. coli belonging to subclone H22 (clade B), the precursor of subclone H30. We sequenced the whole genome of fecal H22 strain S250, compared it to the genomes of ExPEC ST131 H30-Rx strain JJ1886 and commensal ST131 H41 strain SE15, sought the H22-H30 genomic differences in our fecal strains and assessed their phenotypic consequences. We detected 173 genes found in the Virulence Factor Database, of which 148 were shared by the three ST131 genomes, whereas some were genome-specific, notably those allowing determination of virotype (D for S250 and C for JJ1886). We found three sequences of the FimH site involved in adhesion: two in S250 and SE15 close and identical, respectively, to that previously reported to confer strong intestinal adhesion, and one in JJ1886, corresponding to that commonly present in uropathogenic E. coli. Among the genes involved in sugar metabolism, one encoding a gluconate kinase lacked in S250 and JJ1886. Although this gene was also absent in both our fecal H22 and H30-R strains, H22 strains showed a higher capacity to grow in minimal medium with gluconate. Among the genes involved in gluconate metabolism, only the ghrB gene differed between S250/H22 and JJ1886/H30-R strains, resulting in different gluconate reductases. Of the genes involved in biofilm formation, two were absent in the three genomes and one, fimB, in the JJ1886 genome. Our fecal H30-R strains lacking intact fimB displayed delayed biofilm formation relative to our fecal H22 strains. The H22 strains differed by subclade B type and plasmid content, whereas the H30-R strains were identical. Phenotypic analysis of our fecal strains based on observed genomic differences between S250 and JJ1886 strains suggests the presence of traits related to bacterial commensalism in our H22 strains and traits commonly found in uropathogenic E. coli in our H30-R strains.

Improved Performance of Protected Catecholic Polysiloxanes for Bioinspired Wet Adhesion to Surface Oxides

DTIC Science & Technology

2012-11-26

1374. (2) Cho, Y.; Sundaram, H. S.; Finlay , J. A.; Dimitriou, M. D.; Callow, M. E.; Callow, J. A.; Kramer, E. J.; Ober, C. K. Biomacromolecules 2012...139−144. (11) Zeng, H.; Hwang, D. S.; Israelachvili, J. N .; Waite, J. H. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 12850−12853. (12) Holten-Andersen, N ...Haeshin, L.; Dellatore, S. M.; Miller, W. M.; Messersmith, P. B. Science 2007, 318, 426−430. (14) Ling, D.; Park, W.; Park, Y. I.; Lee, N .; Li, F

Rapid and selective detection of E. coli O157:H7 combining phagomagnetic separation with enzymatic colorimetry.

PubMed

Zhang, Yun; Yan, Chenghui; Yang, Hang; Yu, Junping; Wei, Hongping

2017-11-01

Mammal IgG antibodies are normally used in conventional immunoassays for E. coli O157:H7, which could lead to false positive results from the presence of protein A producing S. aureus. In this study, a natural specific bacteriophage was isolated and then conjugated with magnetic beads as a capture element in a sandwich format for the rapid and selective detection of E. coli O157:H7. To the best of our knowledge, it was the first time to utilize a natural bacteriophage to develop a phagomagnetic separation combined with colorimetric assay for E. coli O157:H7. The method has an overall time less than 2h with a detection limit of 4.9×10 4 CFU/mL. No interference from S. aureus was observed. Furthermore, the proposed method was successfully applied to detect E. coli O157:H7 in spiked skim milk. The proposed detection system provided a potential method for E. coli O157:H7 and other pathogenic bacteria in food samples. Copyright © 2017 Elsevier Ltd. All rights reserved.

Gastrointestinal motor inhibition by exogenous human, salmon, and eel calcitonin in conscious dogs.

PubMed

Nakamura, H; Asano, T; Haruta, K; Takeda, K

1995-01-01

Effects of synthetic eel (E-), salmon (S-), and human (H-) calcitonin (CT) on gastrointestinal motility were studied in conscious beagle dogs, which had been implanted with strain gauge force transducers. Intramuscular administration of E-, S-, or H-CT interrupted gastric migrating motor complexes, digestive pattern, and gastric emptying. The order of potency was E-CT = S-CT > H-CT. Motor inhibition induced by CT occurred independently of plasma immunoreactive motilin levels or hypocalcemia. In addition, E-CT and S-CT induced vomiting without a retrograde giant contraction (RGC) during the postprandial state. Apomorphine or CuSO4 initiated RGC prior to vomiting. RGC induced by apomorphine was inhibited by pretreatment with E-CT as well as hexamethonium, atropine, or surgical vagotomy. E-CT showed no inhibitory effect on nicotine stimulated contraction of isolated guinea-pig ileum. These results suggest that peripherally administered CT inhibits canine gastrointestinal motility at the central nervous system level by lowering vagal activity.

Advanced Electron Optics for Vibrational Spectroscopy.

DTIC Science & Technology

1987-10-02

observations of vibrational losses measured 0 2z b n t l o a i r u e h s i by inelastic elctron scattering from surfaces. The basic dif- ference...AFOSR-86-6291 UNCLASSIFIED F/Ci 26/14 U EhEilEEEEEBI / E /EEiEEElh E /EEEE~h R-~ ~ 3 -00 0 0 S *...S :04 *.: UNA A ASSIFIED 469 RT CLASSIFICATION OF THIS...Surfaces", J.L. Erskine, American Vacuum Society Lecture, Texas A&M Unversity, College Station, Texas, April 24,1984. e "Electron Energy Loss Studies of

Antibody Contributes to Heterosubtypic Immunity In the Cotton Rat Model of Influenza

DTIC Science & Technology

2010-09-29

K 1 e t c b l E v v R o M 0 d Vaccine...described in Section 2. accine 24 (2006) 6264–6271 6267 B i o ( r t A 3 v A g A t m ( g w p f i p h i s i m 9 n V h s i p k t c Table 2 Proportion of...5493. Epstein, S.L., C.Y. Lo, J.A. Misplon, C.M. Lawson, B.A. Hendrickson, E.E. Max, K . Subbarao . 1997. Mechanisms of heterosubtypic immunity

Modeling the fate of Escherichia coli O157:H7 and Salmonella enterica in the agricultural environment: current perspective.

PubMed

Ongeng, Duncan; Haberbeck, Leticia U; Mauriello, Gianluigi; Ryckeboer, Jaak; Springael, Dirk; Geeraerd, Annemie H

2014-04-01

The significance of fresh vegetable consumption on human nutrition and health is well recognized. Human infections with Escherichia coli O157:H7 and Salmonella enterica linked to fresh vegetable consumption have become a serious public health problem inflicting a heavy economic burden. The use of contaminated livestock wastes such as manure and manure slurry in crop production is believed to be one of the principal routes of fresh vegetable contamination with E. coli O157:H7 and S. enterica at preharvest stage because both ruminant and nonruminant livestock are known carriers of E. coli O157:H7 and S. enterica in the environment. A number of challenge-testing studies have examined the fate of E. coli O157:H7 and S. enterica in the agricultural environment with the view of designing strategies for controlling vegetable contamination preharvest. In this review, we examined the mathematical modeling approaches that have been used to study the behavior of E. coli O157:H7 and S. enterica in the manure, manure-amended soil, and in manure-amended soil-plant ecosystem during cultivation of fresh vegetable crops. We focused on how the models have been applied to fit survivor curves, predict survival, and assess the risk of vegetable contamination preharvest. The inadequacies of the current modeling approaches are discussed and suggestions for improvements to enhance the applicability of the models as decision tools to control E. coli O157:H7 and S. enterica contamination of fresh vegetables during primary production are presented. © 2014 Institute of Food Technologists®

Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A

NASA Technical Reports Server (NTRS)

Boo, Yong Chool; Sorescu, George; Boyd, Nolan; Shiojima, Ichiro; Walsh, Kenneth; Du, Jie; Jo, Hanjoong

2002-01-01

Recently, we have shown that shear stress stimulates NO(*) production by the protein kinase B/Akt (Akt)-dependent mechanisms in bovine aortic endothelial cells (BAEC) (Go, Y. M., Boo, Y. C., Park, H., Maland, M. C., Patel, R., Pritchard, K. A., Jr., Fujio, Y., Walsh, K., Darley-Usmar, V., and Jo, H. (2001) J. Appl. Physiol. 91, 1574-1581). Akt has been believed to regulate shear-dependent production of NO(*) by directly phosphorylating endothelial nitric-oxide synthase (eNOS) at the Ser(1179) residue (eNOS-S(1179)), but a critical evaluation using specific inhibitors or dominant negative mutants (Akt(AA) or Akt(AAA)) has not been reported. In addition, other kinases, including protein kinase A (PKA) and AMP kinase have also shown to phosphorylate eNOS-S(1179). Here, we show that shear-dependent phosphorylation of eNOS-S(1179) is mediated by an Akt-independent, but a PKA-dependent, mechanism. Expression of Akt(AA) or Akt(AAA) in BAEC by using recombinant adenoviral constructs inhibited phosphorylation of eNOS-S(1179) if cells were stimulated by vascular endothelial growth factor (VEGF), but not by shear stress. As shown before, expression of Akt(AA) inhibited shear-dependent NO(*) production, suggesting that Akt is still an important regulator in NO production. Further studies showed that a selective inhibitor of PKA, H89, inhibited shear-dependent phosphorylation of eNOS-S(1179) and NO(*) production. In contrast, H89 did not inhibit phosphorylation of eNOS-S(1179) induced by expressing a constitutively active Akt mutant (Akt(Myr)) in BAEC, showing that the inhibitor did not affect the Akt pathway. 8-Bromo-cAMP alone phosphorylated eNOS-S(1179) within 5 min without activating Akt, in an H89-sensitive manner. Collectively, these results demonstrate that shear stimulates phosphorylation of eNOS-S(1179) in a PKA-dependent, but Aktindependent manner, whereas the NO(*) production is regulated by the mechanisms dependent on both PKA and Akt. A coordinated interaction between Akt and PKA may be an important mechanism by which eNOS activity is regulated in response to physiological stimuli such as shear stress.

Structure of the Mesophases Formed by a Perfluoroalkyl/Biphenyl Compound. Amphiphilic and Steric Effects

NASA Astrophysics Data System (ADS)

Pensec, Sandrine; Tournilhac, François-Genès; Bassoul, Pierre

1996-11-01

We describe the synthesis and mesomorphic behaviour of 4-(1H,1H-perfluorooctyloxy)- 4'-methoxy biphenyl. Two mesophases of smectic E and smectic A types were observed. X-ray diffraction study of the smectic E phase indicates a herringbone arrangement of the biphenyl cores, the perfluoroalkyl chains being in a molten state. The {S_E to S_A} transition is related to the melting of the biphenyl sublattice. In both phases, the flexibility of perfluoroalkyl chains permits the area matching between the two segregated sublayers. Nous décrivons la synthèse et les propriétés mésomorphes du 4-(1H,1H-perfluorooctyloxy)- 4'-méthoxy biphényle. Ce composé forme deux mésophases de type smectique E et smectique A. L'analyse par diffraction des rayons X révèle, dans le cas de la phase smectique E un arrangement en chevrons des coeurs biphényles, les chaînes perfluoroalkyles se trouvant dans un état désordonné. La transition {S_E to S_A} correspond à la fusion partielle de la sous-couche biphényle. Dans les deux phases smectiques, la flexibilité des chaînes perfluoroalkyles permet l'adéquation des aires moléculaires entre les deux sous-couches ségrégées.

Effect of slightly acidic electrolyzed water for inactivating Escherichia coli O157:H7 and Staphylococcus aureus analyzed by transmission electron microscopy.

PubMed

Nan, Songjian; Yongyu, L I; Baoming, L I; Wang, Chaoyuan; Cui, Xiaodong; Cao, Wei

2010-12-01

The use of different available chlorine concentrations (ACCs) of slightly acidic electrolyzed water (SAEW; 0.5 to 30 mg/liter), different treatment times, and different temperatures for inactivating Escherichia coli O157:H7 and Staphylococcus aureus was evaluated. The morphology of both pathogens also was analyzed with transmission electron microscopy. A 3-min treatment with SAEW (pH 6.0 to 6.5) at ACCs of 2 mg/liter for E. coli O157:H7 and 8 mg/liter for S. aureus resulted in 100% inactivation of two cultures (7.92- to 8.75-log reduction) at 25°C. The bactericidal activity of SAEW was independent of the treatment time and temperature at a higher ACC (P > 0.05). E. coli O157:H7 was much more sensitive than S. aureus to SAEW. The morphological damage to E. coli O157:H7 cells by SAEW was significantly greater than that to S. aureus cells. At an ACC as high as 30 mg/liter, E. coli O157:H7 cells were damaged, but S. aureus cells retained their structure and no cell wall damage or shrinkage was observed. SAEW with a near neutral pH may be a promising disinfectant for inactivation of foodborne pathogens.

On the star partition dimension of comb product of cycle and complete graph

NASA Astrophysics Data System (ADS)

Alfarisi, Ridho; Darmaji; Dafik

2017-06-01

Let G = (V, E) be a connected graphs with vertex set V (G), edge set E(G) and S ⊆ V (G). For an ordered partition Π = {S 1, S 2, S 3, …, Sk } of V (G), the representation of a vertex v ∈ V (G) with respect to Π is the k-vectors r(v|Π) = (d(v, S 1), d(v, S 2), …, d(v, Sk )), where d(v, Sk ) represents the distance between the vertex v and the set Sk , defined by d(v, Sk ) = min{d(v, x)|x ∈ Sk}. The partition Π of V (G) is a resolving partition if the k-vektors r(v|Π), v ∈ V (G) are distinct. The minimum resolving partition Π is a partition dimension of G, denoted by pd(G). The resolving partition Π = {S 1, S 2, S 3, …, Sk} is called a star resolving partition for G if it is a resolving partition and each subgraph induced by Si , 1 ≤ i ≤ k, is a star. The minimum k for which there exists a star resolving partition of V (G) is the star partition dimension of G, denoted by spd(G). Finding a star partition dimension of G is classified to be a NP-Hard problem. Furthermore, the comb product between G and H, denoted by G ⊲ H, is a graph obtained by taking one copy of G and |V (G)| copies of H and grafting the i-th copy of H at the vertex o to the i-th vertex of G. By definition of comb product, we can say that V (G ⊲ H) = {(a, u)|a ∈ V (G), u ∈ V (H)} and (a, u)(b, v) ∈ E(G ⊲ H) whenever a = b and uv ∈ E(H), or ab ∈ E(G) and u = v = o. In this paper, we will study the star partition dimension of comb product of cycle and complete graph, namely Cn ⊲ Km and Km ⊲ Cn for n ≥ 3 and m ≥ 3.

Fixed-wing Aircraft Combat Survivability Analysis for Operation Enduring Freedom and Operation Iraqi Freedom

DTIC Science & Technology

2011-03-01

H V ul ne ra bi lit y, P K │ H Ti m e Figure 2-2: One vs. One Kill Chain (Single Shot), taken from [6...ENGAGEMENT ENDGAME VULNERABILITY (2) (0) (3) (4) (5) (1) P S S P K │ SS Su sc ep tib ili ty , P H V ul ne ra bi lit y, P K │ H Ti m e Figure 2-3...Evaluation M &S Modeling and Simulation MANPADS Man Portable Air Defense Systems MDS Mission Design Series NMC Non-Mission Capable xii

Growth advantage of Escherichia coli O104:H4 strains on 5-N-acetyl-9-O-acetyl neuraminic acid as a carbon source is dependent on heterogeneous phage-Borne nanS-p esterases.

PubMed

Saile, Nadja; Schwarz, Lisa; Eißenberger, Kristina; Klumpp, Jochen; Fricke, Florian W; Schmidt, Herbert

2018-06-01

Enterohemorrhagic E. coli (EHEC) are serious bacterial pathogens which are able to cause a hemorrhagic colitis or the life-threatening hemolytic-uremic syndrome (HUS) in humans. EHEC strains can carry different numbers of phage-borne nanS-p alleles that are responsible for acetic acid release from mucin from bovine submaxillary gland and 5-N-acetyl-9-O-acetyl neuraminic acid (Neu5,9Ac 2 ), a carbohydrate present in mucin. Thus, Neu5,9Ac 2 can be transformed to 5-N-acetyl neuraminic acid, an energy source used by E. coli strains. We hypothesize that these NanS-p proteins are involved in competitive growth of EHEC in the gastrointestinal tract of humans and animals. The aim of the current study was to demonstrate and characterize the nanS-p alleles of the 2011 E. coli O104:H4 outbreak strain LB226692 and analyze whether the presence of multiple nanS-p alleles in the LB226692 genome causes a competitive growth advantage over a commensal E. coli strain. We detected and characterized five heterogeneous phage-borne nanS-p alleles in the genome of E. coli O104:H4 outbreak strain LB226692 by in silico analysis of its genome. Furthermore, successive deletion of all nanS-p alleles, subsequent complementation with recombinant NanS-p13-His, and in vitro co-culturing experiments with the commensal E. coli strain AMC 198 were conducted. We could show that nanS-p genes of E. coli O104:H4 are responsible for growth inhibition of strain AMC 198, when Neu5,9Ac 2 was used as sole carbon source in co-culture. The results of this study let us suggest that multiple nanS-p alleles may confer a growth advantage by outcompeting other E. coli strains in Neu5,9Ac 2 rich environments, such as mucus in animal and human gut. Copyright © 2018 Elsevier GmbH. All rights reserved.

Compile-Time Partitioning and Scheduling of Parallel Programs. Extended Summary,

DTIC Science & Technology

1986-01-01

OO-MI70 9PROGRAMS EXTENED, SUMNNRY(U) STANFORD, UNIV CA COMPUTERSYSTEMS LAO V SARKAR ET AL. L986 MDA9S3-SS-C-S432 UNCLASSIFIEDj F/ G 9/2 H El- 1 9 5...9 C M E h h h" E P RIIN N E O UI G O Fh E L i E Eu Iwle ui J l~I-O IWI INW 2-5 1= 13.111 2-2 l o U l1 . A 12- "m ’- - "- m°" m ’o ’ l ’. , " l...J. A. et al. "Parallel Processing: A Smart Compiler and a Dumb Machine". SIGPLAN Notices 19, 6 (June 1984). 8. Gajski , D. D., Padua, D. K. & Kuck, D

Thermal Design of Boiler Unit (Standard Method).

DTIC Science & Technology

1980-04-29

T-0411-80" h EhlllllEI mhEhhhhh m~lEElhElllllE Elhllllllhllll llllllllmllllu llllllllhllllu "’FTD-ID(RS)T-0411-80 FOREIGN TECHNOLOGY DIVISION THERMAL...Block italic Transliter. - - A a A, a P p p p R, r S B, b C C S B V, v T m , t r g Y y SD, d SE a Ye, ye; E, e* x X x Kh, , W Zc h , z h L 4 Ti , L...sh sn arc_4n 6 ch cosh arc or -. tar. th tanh arc t- Scot zth cct arc c’- h sec Sch sech arc sc- . - o-ec csc cscn cs ch aronc sc Russian Er.I n h rot

E.S.R., magnetic, electronic and superoxide dismutase studies of imidazolate-bridged Cu(II)-Cu(II) complexes with ethylenediamine as capping ligand.

PubMed

Patel, R N; Singh, Nripendra; Shukla, K K; Gundla, V L N

2005-06-01

X-band E.S.R., magnetic and electronic spectra of some imidazolate-bridged homometallic complexes [(en)2Cu-R-Im-Cu(en)2](ClO4)3 where en, ethylenediamine; R-ImH, R = H imidazole (ImH); if R = CH3, 2-methylimidazole (M-ImH) and if R = C2H5, 2-ethylimidazole (E-ImH), and mononuclear complexes [(en)Cu-dien](ClO4)2 and [(en)Cu-PMDT](ClO4)2 where dien, diethylenetriamine; PMDT, pentamethyldiethylenetriamine have been described. Superoxide dismutase (SOD) activity has also been measured and compared with earlier reported complexes. In frozen solution at 77 K, the spectra show axial symmetry with a d(x2-y2) ground state. Difference in lambda(max) between mononuclear and binuclear complexes was found to be approximately 65-75 nm. Magnetic susceptibility and E.S.R. spectral measurements for all these binuclear complexes revealed that the copper(II) ions are involved in antiferromagnetic exchange interactions propagated by the imidazolate bridge.

Measurement of the EBL spectral energy distribution using the VHE γ-ray spectra of H.E.S.S. blazars

NASA Astrophysics Data System (ADS)

H. E. S. S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Andersson, T.; Angüner, E. O.; Arakawa, M.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Tjus, J. Becker; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bonnefoy, S.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Capasso, M.; Carr, J.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Coffaro, M.; Colafrancesco, S.; Cologna, G.; Condon, B.; Conrad, J.; Cui, Y.; Davids, I. D.; Decock, J.; Degrange, B.; Deil, C.; Devin, J.; de Wilt, P.; Dirson, L.; Djannati-Ataï, A.; Domainko, W.; Donath, A.; Drury, L. O.'C.; Dutson, K.; Dyks, J.; Edwards, T.; Egberts, K.; Eger, P.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Funk, S.; Füßling, M.; Gabici, S.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Gottschall, D.; Goyal, A.; Grondin, M.-H.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holch, T. L.; Holler, M.; Horns, D.; Ivascenko, A.; Iwasaki, H.; Jacholkowska, A.; Jamrozy, M.; Janiak, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jogler, T.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katsuragawa, M.; Katz, U.; Kerszberg, D.; Khangulyan, D.; Khélifi, B.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Kraus, M.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lefranc, V.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morå, K.; Moulin, E.; Murach, T.; Nakashima, S.; de Naurois, M.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Rauth, R.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Richter, S.; Rieger, F.; Romoli, C.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Saito, S.; Salek, D.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Simoni, R.; Sol, H.; Spanier, F.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stycz, K.; Sushch, I.; Takahashi, T.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tsuji, N.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zaborov, D.; Zacharias, M.; Zanin, R.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Żywucka, N.

2017-10-01

Very high-energy γ rays (VHE, E ≳ 100 GeV) propagating over cosmological distances can interact with the low-energy photons of the extragalactic background light (EBL) and produce electron-positron pairs. The transparency of the Universe to VHE γ rays is then directly related to the spectral energy distribution (SED) of the EBL. The observation of features in the VHE energy spectra of extragalactic sources allows the EBL to be measured, which otherwise is very difficult. An EBL model-independent measurement of the EBL SED with the H.E.S.S. array of Cherenkov telescopes is presented. It was obtained by extracting the EBL absorption signal from the reanalysis of high-quality spectra of blazars. From H.E.S.S. data alone the EBL signature is detected at a significance of 9.5σ, and the intensity of the EBL obtained in different spectral bands is presented together with the associated γ-ray horizon.

77 FR 66196 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Extension of Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-02

....\\4\\ \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. \\3\\ Securities Exchange Act Release No. 67835...\\ 12 U.S.C. 5465(e)(1)(H). The Commission finds it is appropriate to extend the review period for the... for OTC S&P 500 Index options. Accordingly, the Commission, pursuant to 806(e)(1)(H) of the Clearing...

Hydrogen sulfide facilities production of nitric oxide via the Akt/endothelial nitric oxide synthases signaling pathway to protect human umbilical vein endothelial cells from injury by angiotensin II.

PubMed

Cui, Jiasen; Zhuang, Shunjiu; Qi, Shaohong; Li, Li; Zhou, Junwen; Zhang, Wan; Zhao, Yun; Qi, Ning; Yin, Yangjun; Huang, Lu

2017-11-01

Angiotensin II (Ang II) has been reported as key in inducing endothelial cell injury, and endothelial cells may produce nitric oxide (NO) to protect themselves. However, the underlying mechanism remains elusive. Human umbilical vein endothelial cells (HUVECs) were divided into five treatment groups as follows: Normal control, Ang II, Ang II + sodium hydrosulfide [NaHS; hydrogen sulfide (H2S) donor], Ang II + Akt inhibitors + NaHS, and Ang II + endothelial nitric oxide synthases (eNOS) inhibitors + NaHS. Subsequently, cell viability, apoptosis, migration, proliferation and adhesion ability were determined. In addition, tubular structure formation was observed, and the NO and phosphorylation levels of Akt and eNOS were evaluated. Compared with the normal control group, Ang II treatment reduced the viability of HUVECs and increased the level of cell apoptosis (P<0.05). Furthermore, Ang II treatment inhibited the phosphorylation level of eNOS and Akt, as well as the generation of NO (P<0.05). H2S reversed the above‑mentioned effects significantly and increased cell proliferation, adhesion ability and promoted tubular structure formation (P<0.05); however, H2S did not reverse the impact of eNOS and Akt phosphorylation levels after being processed with Akt and eNOS inhibitors, which indicates that H2S is capable of protecting HUVECs via the eNOS/Akt signaling pathway (P<0.05). Thus, H2S stimulates the production of NO and protects HUVECs via inducing the Akt/eNOS signaling pathway.

Ship Production Symposium Held in Long Beach, California on September 11-13, 1985. Volume 2 (The National Shipbuilding Research Program)

DTIC Science & Technology

1985-09-01

t h e long- term we are comple te ly redes ign ing the Weapon Systems F i le c o m p u t e r s o f t w a r e s o t h a t i t i s f u l l y ...sidewall 6) ability to repair surface defects by carbon arcing and grinding -572- LIST OF REFERENCES 1) Kimura, S., Ichihara, I., and Nagai, Y ...5.5 inch/min) (50/60 Hz) Stroke: 350mm (I 3.8 inch) electric inching method M o u n t i n g A s s e m b l y ) Vertical Head adjustment Slide speed

Na(+) transport, and the E(1)P-E(2)P conformational transition of the Na(+)/K(+)-ATPase.

PubMed Central

Babes, A; Fendler, K

2000-01-01

We have used admittance analysis together with the black lipid membrane technique to analyze electrogenic reactions within the Na(+) branch of the reaction cycle of the Na(+)/K(+)-ATPase. ATP release by flash photolysis of caged ATP induced changes in the admittance of the compound membrane system that are associated with partial reactions of the Na(+)/K(+)-ATPase. Frequency spectra and the Na(+) dependence of the capacitive signal are consistent with an electrogenic or electroneutral E(1)P <--> E(2)P conformational transition which is rate limiting for a faster electrogenic Na(+) dissociation reaction. We determine the relaxation rate of the rate-limiting reaction and the equilibrium constants for both reactions at pH 6.2-8.5. The relaxation rate has a maximum value at pH 7.4 (approximately 320 s(-1)), which drops to acidic (approximately 190 s(-1)) and basic (approximately 110 s(-1)) pH. The E(1)P <--> E(2)P equilibrium is approximately at a midpoint position at pH 6.2 (equilibrium constant approximately 0.8) but moves more to the E(1)P side at basic pH 8.5 (equilibrium constant approximately 0.4). The Na(+) affinity at the extracellular binding site decreases from approximately 900 mM at pH 6.2 to approximately 200 mM at pH 8.5. The results suggest that during Na(+) transport the free energy supplied by the hydrolysis of ATP is mainly used for the generation of a low-affinity extracellular Na(+) discharge site. Ionic strength and lyotropic anions both decrease the relaxation rate. However, while ionic strength does not change the position of the conformational equilibrium E(1)P <--> E(2)P, lyotropic anions shift it to E(1)P. PMID:11053130

Toward a Global 1/25 deg HYCOM Ocean Prediction System with Tides

DTIC Science & Technology

2011-09-30

Wallcraft, C. Lozano, H. L.Tolman, A. Srinivasan, S. Hankin, P. Cornillon, R. Weisberg, A. Barth, R. He, C. Werner, and J. Wilkin , 2009. U.S. GODAE...United States. Climate Dynamics, doi:10.1007/s00382-010-0988-7. Xu, X., W.J. Schmitz Jr., H.E. Hurlburt, P.J. Hogan , and E.P. Chassignet, 2010. Transport

Naval Operations: A Close Look at the Operational Level of War at Sea

DTIC Science & Technology

2012-07-01

strategic.’”6 Among non-American examples there are no better illustrations than Italian admiral Romeo Bernotti’s two fine books on tactics and strategy...vital role of operational art in testing every strategy. N O T E S H U G H E S 45 7. Two excellent authorities are Michael Vlahos, “Wargaming, an

Persistence of Escherichia coli O157:H7 in dairy fermentation systems.

PubMed

Dineen, S S; Takeuchi, K; Soudah, J E; Boor, K J

1998-12-01

We examined (i) the persistence of Escherichia coli O157:H7 as a postpasteurization contaminant in fermented dairy products; (ii) the ability of E. coli O157:H7 strains with and without the general stress regulatory protein, RpoS, to compete with commercial starter cultures in fermentation systems; and (iii) the survival of E. coli O157:H7 in the yogurt production process. In commercial products inoculated with 10(3) CFU/ml, E. coli O157:H7 was recovered for up to 12 days in yogurt (pH 4.0), 28 days in sour cream (pH 4.3), and at levels > 10(2) CFU/ml at 35 days in buttermilk (pH 4.1). For the starter culture competition trials, the relative inhibition of E. coli O157:H7 in the experimental fermentation systems was, in decreasing order, thermophilic culture mixture, Lactobacillus delbrueckii subsp. bulgaricus R110 alone, Lactococcus lactis subsp. lactis D280 alone, Lactococcus lactis subsp. cremoris D62 alone, and Streptococcus thermophilus C90 alone showing the least inhibition. Recovery of the rpoS mutant was lower than recovery of its wild-type parent by 72 h or earlier in the presence of individual starter cultures. No E. coli O157:H7 were recovered after the curd formation step in yogurt manufactured with milk inoculated with 10(5) CFU/ml. Our results show that (i) postprocessing entry of E. coli O157:H7 into fermented dairy products represents a potential health hazard; (ii) commercial starter cultures differ in their ability to reduce E. coli O157:H7 CFU numbers in fermentation systems; and (iii) the RpoS protein appears to most effectively contribute to bacterial survival in the presence of conditions that are moderately lethal to the cell.

A comparative study of low pH stress in E. coli and S. typhimurium, and a comparative study of the inducibility of lysyl-tRNA synthetase in the enterobacteriaceae

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hickey, E.W.

1988-01-01

Lysyl-tRNA synthetase (LRS) in Escherichia coli is coded by two genes, one constitutive, and the other inducible. The commonness of inducibility of this enzyme in prokaryotes was first tested in eight members of the Enterobacteriaceae using culture conditions known to induce it in E. coli. LRS was found to be inducible in Salmonella Typhimurium, Citrobacter freundii, Klebsiella pneumoniae and Enterobacter aerogenes, but not in Serratia marcescens, Proteus mirabilis, Proteus vulgaris or Morganella morganii. The results also indicated that LRS was not induced in E. coli grown in defined medium (SMM) at an external pH (pH{sub 0}) of 5.0, whereas, itmore » was induced in S. typhimurium under this condition. Further investigation of low pH{sub 0} induced behavior in E. coli and S. typhimurium by quantitation of H{sub 2} {sup 35}SO{sub 4} labeled proteins from two dimensional polyacrylamide gels of whole cell sonic extracts showed that at least twenty proteins were induced from 2- to 16-fold in S. typhimurium grown at pH{sub 0} 5.0 or shifted from growth at pH{sub 0} 7.0 to 5.0. Internal pH (pH{sub i}) changes occurring during steady state growth at low pH{sub 0}, and on shifting from pH{sub 0} 7.0 to 5.0, were measured using {sup 14}C-benzoic acid uptake.« less

A revision of the Axylus group of Agraeciini (Orthoptera: Tettigoniidae: Conocephalinae) and of some other species formerly included in Nicsara or Anthracites Revision of the Indo-Australian Conocephalinae, Part 3.

PubMed

Ingrisch, Sigfrid

2015-11-23

Axylus group is used to include the five genera Axylus Stål, 1877, Anthracites Redtenbacher, 1891 sensu stricto, Eucoptaspis Willemse, 1966, Eulobaspis gen. nov., and Heminicsara Karny, 1912. It is mainly based on a combination of the characters shape of pronotum, spiniform meso- and metasternal lobes, and similar basic ground plans of the male cerci, titillators and female subgenital plates. The five genera together with two superficially similar genera Euanthracites gen. nov. and Sulasara gen. nov. are fully revised. Papuacites gen. nov. is proposed for two New Guinean species formerly included in Anthracites. Nicsara Walker, 1869 is restricted to Australian species; Spinisternum Willemse, 1942 is synonymised with Heminicsara Karny, 1912; Odontocoryphus Karny, 1907 based on two nymphs is synonymised with Macroxiphus Pictet, 1888; Pseudoliara Karny, 1907 described after one nymph is regarded incertae sedis. 40 new combination of species are proposed: Axylus bimaculatus (Redtenbacher, 1891) comb. nov., A. inferior (Brunner, 1898) comb. nov., A. inflatus (Brunner, 1898) comb. nov., A. loboensis (De Haan, 1842) comb. nov., A. minutus (Dohrn, 1905) comb. nov., A. nigrifrons (Brunner, 1898) comb. nov., A. philippinus (Hebard, 1922) comb. nov., A, taylori (Hebard, 1922) comb. nov., and A. thoracicus (Dohrn, 1905) comb. nov. (all from Nicsara); Euanthracites apoensis (Hebard, 1922) comb. nov., E. femoralis (Dohrn, 1905) comb. nov., E. rufus (Ingrisch, 1998) comb. nov., and E. tibialis (Karny, 1931) comb. nov. (from Anthracites); Eucoptaspis inexpectatus (Willemse, 1953) comb. nov. (from Gonatacanthus Karny, 1907); Eulobaspis dehaani (Karny, 1920) comb. nov., E. emarginata (Karny, 1926) comb. nov., E. moluccana (Redtenbacher, 1891) comb. nov., E. personata (Karny, 1926) comb. nov., E. quadrimaculata (Karny, 1926) comb. nov., E. rotundata (Karny, 1926) comb. nov., and E. strigatipes (Bolivar, 1898) comb. nov. (from Nicsara); Eulobaspis lobaspoides (Karny, 1907) comb. nov. and E. ornata (Brunner, 1898) comb. nov. (from Axylus); Heminicsara excisa (Karny, 1926) comb. nov., H. insulana (Willemse, 1966) comb. nov., H. schlaginhaufeni (Karny, 1912) comb. nov., and H. viridipes (Karny, 1912) comb. nov. (from Nicsara); Heminicsara castaneipictus (Willemse, 1966) comb. nov., H. insularis (Willemse, 1942) comb. nov., and H. palauensis (Vickery & Kevan, 1999) comb. nov. (from Spinisternum); Heminicsara decipiens (Karny, 1926) comb. nov. and H. griffinii (Karny, 1911) comb. nov. (from Gonatacanthus); Heminicsara novaeguineae (Willemse, 1966) comb. nov. (from Eucoptaspis); Sulasara aethiops (Karny, 1931) comb. nov., S. karnyi (Willemse, 1932) comb. nov., and Sulasara sarasini (Karny, 1931) comb. nov. (from Nicsara); Papuacites nigrifrons (Karny, 1912) comb. nov. and P. nakanaiensis (Naskrecki & Rentz, 2010) comb. nov. (from Anthracites); Paramacroxiphus multispinosa (Bolivar, 1898) comb. nov. (from Nicsara); Palaeoagraecia globiceratus Vickery & Kevan, 1999 comb. nov. (from Macroxiphus). Odontocoryphus pullus Karny, 1907 becomes a new synonym of Macroxiphus sumatranus sumatranus (Haan, 1842). 87 species are described as new: nine species in Axylus: A. brachypterus sp. nov., A. dulang sp. nov., A. furcatus sp. nov., A. mengkoka sp. nov., A. montanus sp. nov., A. negros sp. nov. , A. superior sp. nov., A. totop sp. nov. , A. unicolor sp. nov.; six species in Anthracites: A. bilineatus sp. nov., A. flagellatus sp. nov., A. pyramidalis sp. nov., A. romblon sp. nov., A. sinuatus sp. nov., A. unispinus sp. nov.; four species in Euanthracites: E. bispinus sp. nov., E. eboreus sp. nov., E. ile sp. nov., E. uru sp. nov.; six species in Eucoptaspis: E. adonara sp. nov., E. hexamaculatus sp. nov., E. remotus sp. nov., E. stylatus sp. nov., E. trapezoides sp. nov., E. wawo sp. nov.; eight species in Eulobaspis: E. bacan C.Willemse & Ingrisch sp. nov., E. baduri sp. nov., E. buruensis sp. nov., E. ceramica C.Willemse & Ingrisch sp. nov., E. morotai sp. nov., E. sudirman sp. nov., E. ternate sp. nov., E. variata sp. nov.; 51 species in Heminicsara: H. albatros sp. nov., H. albipuncta sp. nov., H. albogeniculata Naskrecki & Ingrisch sp. nov., H. alticola sp. nov., H. ammea sp. nov., H. anggi sp. nov., H. bilobata sp. nov., H. cingima sp. nov., H. comprima sp. nov., H. coriformis sp. nov., H. corneli sp. nov., H. cyclops sp. nov., H. despecta Naskrecki & Ingrisch sp. nov., H. dilatata sp. nov., H. dividata sp. nov., H. dobo sp. nov., H. elongata Naskrecki & Ingrisch sp. nov., H. furcata sp. nov., H. gibba sp. nov., H. gugusu Naskrecki & Ingrisch sp. nov., H. illugi sp. nov., H. jacobii Karny, 1912, H. jayawijaya sp. nov., H. kelila sp. nov., H. kolombangara sp. nov., H. lamas Naskrecki & Ingrisch sp. nov., H. longiloba sp. nov., H. lord sp. nov., H. malu sp. nov., H. mamberamo sp. nov., H. manus sp. nov., H. montana sp. nov., H. nigra sp. nov., H. nomoensis sp. nov., H. obiensis sp. nov., H. ohu sp. nov., H. pak sp. nov., H. parallela Naskrecki & Ingrisch sp. nov., H. pinniger sp. nov., H. popoman sp. nov., H. rugosa sp. nov., H. scutula sp. nov., H. sica sp. nov., H. sinewit sp. nov., H. siwi sp. nov., H. stylata sp. nov., H. tabtab sp. nov., H. truncata Naskrecki & Ingrisch sp. nov., H. tumulus sp. nov., H. umasani sp. nov., H. wanuma sp. nov., H. zugi sp. nov.; and three species in Sulasara: S. armata sp. nov., S. renschi sp. nov., S. tambu sp. nov.

Revised model core potentials for third-row transition-metal atoms from Lu to Hg

NASA Astrophysics Data System (ADS)

Mori, Hirotoshi; Ueno-Noto, Kaori; Osanai, You; Noro, Takeshi; Fujiwara, Takayuki; Klobukowski, Mariusz; Miyoshi, Eisaku

2009-07-01

We have produced new relativistic model core potentials (spdsMCPs) for the third-row transition-metal atoms from Lu to Hg explicitly treating explicitly 5s and 5p electrons in addition to 5d and 6s electrons in the same manner for the first- and second-row transition-metal atoms given in the previous Letters [Y. Osanai, M.S. Mon, T. Noro, H. Mori, H. Nakashima, M. Klobukowski, E. Miyoshi, Chem. Phys. Lett. 452 (2008) 210; Y. Osanai, E. Soejima, T. Noro, H. Mori, M.S. Mon, M. Klobukowski, E. Miyoshi, Chem. Phys. Lett. 463 (2008) 230]. Using suitable correlating functions with the split-valence MCP functions, we demonstrate that the present MCP basis sets show reasonable performance in describing the electronic structures of atoms and molecules, bringing about accurate excitation energies for atoms and proper spectroscopic constants for Au 2, Hg 2, and AuH.

Dehydroepiandrosterone Derivatives as Potent Antiandrogens with Marginal Agonist Activity

DTIC Science & Technology

2012-07-01

press. Other Presentations/Abstracts 1. Gordetsky J, Subik K, Choy B, Varghese M, Messing E, Miyamoto H, Yeh S: Analysis of tocopherol -associated...Abstract published in Arch Pathol Lab Med 135(9): 1128, 2011. 7 4. Gordetsky J, Varghese M, Messing E, Miyamoto H, Yeh S: Analysis of tocopherol - associated

Search for the rare decays D →h (h('))e+e-

NASA Astrophysics Data System (ADS)

Ablikim, M.; Achasov, M. N.; Ahmed, S.; Albrecht, M.; Alekseev, M.; Amoroso, A.; An, F. F.; An, Q.; Bai, J. Z.; Bai, Y.; Bakina, O.; Baldini Ferroli, R.; Ban, Y.; Begzsuren, K.; Bennett, D. W.; Bennett, J. V.; Berger, N.; Bertani, M.; Bettoni, D.; Bianchi, F.; Boger, E.; Boyko, I.; Briere, R. A.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chai, J.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, P. L.; Chen, S. J.; Chen, X. R.; Chen, Y. B.; Cheng, W.; Chu, X. K.; Cibinetto, G.; Cossio, F.; Dai, H. L.; Dai, J. P.; Dbeyssi, A.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; de Mori, F.; Ding, Y.; Dong, C.; Dong, J.; Dong, L. Y.; Dong, M. Y.; Dou, Z. L.; Du, S. X.; Duan, P. F.; Fang, J.; Fang, S. S.; Fang, Y.; Farinelli, R.; Fava, L.; Fegan, S.; Feldbauer, F.; Felici, G.; Feng, C. Q.; Fioravanti, E.; Fritsch, M.; Fu, C. D.; Gao, Q.; Gao, X. L.; Gao, Y.; Gao, Y. G.; Gao, Z.; Garillon, B.; Garzia, I.; Gilman, A.; Goetzen, K.; Gong, L.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guo, A. Q.; Guo, R. P.; Guo, Y. P.; Guskov, A.; Haddadi, Z.; Han, S.; Hao, X. Q.; Harris, F. A.; He, K. L.; He, X. Q.; Heinsius, F. H.; Held, T.; Heng, Y. K.; Hou, Z. L.; Hu, H. M.; Hu, J. F.; Hu, T.; Hu, Y.; Huang, G. S.; Huang, J. S.; Huang, X. T.; Huang, X. Z.; Huang, Z. L.; Hussain, T.; Ikegami Andersson, W.; Irshad, M.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, X. S.; Jiang, X. Y.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Jin, Y.; Johansson, T.; Julin, A.; Kalantar-Nayestanaki, N.; Kang, X. S.; Kavatsyuk, M.; Ke, B. C.; Keshk, I. K.; Khan, T.; Khoukaz, A.; Kiese, P.; Kiuchi, R.; Kliemt, R.; Koch, L.; Kolcu, O. B.; Kopf, B.; Kornicer, M.; Kuemmel, M.; Kuessner, M.; Kupsc, A.; Kurth, M.; Kühn, W.; Lange, J. S.; Larin, P.; Lavezzi, L.; Leithoff, H.; Li, C.; Li, Cheng; Li, D. M.; Li, F.; Li, F. Y.; Li, G.; Li, H. B.; Li, H. J.; Li, J. C.; Li, J. W.; Li, Jin; Li, K. J.; Li, Kang; Li, Ke; Li, Lei; Li, P. L.; Li, P. R.; Li, Q. Y.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Liao, L. Z.; Libby, J.; Lin, C. X.; Lin, D. X.; Liu, B.; Liu, B. J.; Liu, C. X.; Liu, D.; Liu, D. Y.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H. B.; Liu, H. L.; Liu, H. M.; Liu, Huanhuan; Liu, Huihui; Liu, J. B.; Liu, J. Y.; Liu, K.; Liu, K. Y.; Liu, Ke; Liu, L. D.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqing; Long, Y. F.; Lou, X. C.; Lu, H. J.; Lu, J. G.; Lu, Y.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lusso, S.; Lyu, X. R.; Ma, F. C.; Ma, H. L.; Ma, L. L.; Ma, M. M.; Ma, Q. M.; Ma, T.; Ma, X. N.; Ma, X. Y.; Ma, Y. M.; Maas, F. E.; Maggiora, M.; Maldaner, S.; Malik, Q. A.; Mangoni, A.; Mao, Y. J.; Mao, Z. P.; Marcello, S.; Meng, Z. X.; Messchendorp, J. G.; Mezzadri, G.; Min, J.; Mitchell, R. E.; Mo, X. H.; Mo, Y. J.; Morales Morales, C.; Muchnoi, N. Yu.; Muramatsu, H.; Mustafa, A.; Nefedov, Y.; Nerling, F.; Nikolaev, I. B.; Ning, Z.; Nisar, S.; Niu, S. L.; Niu, X. Y.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Pan, Y.; Papenbrock, M.; Patteri, P.; Pelizaeus, M.; Pellegrino, J.; Peng, H. P.; Peng, Z. Y.; Peters, K.; Pettersson, J.; Ping, J. L.; Ping, R. G.; Pitka, A.; Poling, R.; Prasad, V.; Qi, H. R.; Qi, M.; Qi, T. Y.; Qian, S.; Qiao, C. F.; Qin, N.; Qin, X. S.; Qin, Z. H.; Qiu, J. F.; Qu, S. Q.; Rashid, K. H.; Redmer, C. F.; Richter, M.; Ripka, M.; Rivetti, A.; Rolo, M.; Rong, G.; Rosner, Ch.; Sarantsev, A.; Savrié, M.; Schoenning, K.; Shan, W.; Shan, X. Y.; Shao, M.; Shen, C. P.; Shen, P. X.; Shen, X. Y.; Sheng, H. Y.; Shi, X.; Song, J. J.; Song, W. M.; Song, X. Y.; Sosio, S.; Sowa, C.; Spataro, S.; Sun, G. X.; Sun, J. F.; Sun, L.; Sun, S. S.; Sun, X. H.; Sun, Y. J.; Sun, Y. K.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tan, Y. T.; Tang, C. J.; Tang, G. Y.; Tang, X.; Tapan, I.; Tiemens, M.; Tsednee, B.; Uman, I.; Wang, B.; Wang, B. L.; Wang, D.; Wang, D. Y.; Wang, Dan; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, Meng; Wang, P.; Wang, P. L.; Wang, W. P.; Wang, X. F.; Wang, Y.; Wang, Y. F.; Wang, Z.; Wang, Z. G.; Wang, Z. Y.; Wang, Zongyuan; Weber, T.; Wei, D. H.; Weidenkaff, P.; Wen, S. P.; Wiedner, U.; Wolke, M.; Wu, L. H.; Wu, L. J.; Wu, Z.; Xia, L.; Xia, Y.; Xiao, D.; Xiao, Y. J.; Xiao, Z. J.; Xie, Y. G.; Xie, Y. H.; Xiong, X. A.; Xiu, Q. L.; Xu, G. F.; Xu, J. J.; Xu, L.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Yan, F.; Yan, L.; Yan, W. B.; Yan, W. C.; Yan, Y. H.; Yang, H. J.; Yang, H. X.; Yang, L.; Yang, R. X.; Yang, Y. H.; Yang, Y. X.; Yang, Yifan; Yang, Z. Q.; Ye, M.; Ye, M. H.; Yin, J. H.; You, Z. Y.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yu, J. S.; Yuan, C. Z.; Yuan, Y.; Yuncu, A.; Zafar, A. A.; Zeng, Y.; Zhang, B. X.; Zhang, B. Y.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J.; Zhang, J. L.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, K.; Zhang, L.; Zhang, T. J.; Zhang, X. Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Y. T.; Zhang, Yang; Zhang, Yao; Zhang, Yu; Zhang, Z. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, J. W.; Zhao, J. Y.; Zhao, J. Z.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, W. J.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, Q.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhou, X. Y.; Zhou, Xiaoyu; Zhou, Xu; Zhu, A. N.; Zhu, J.; Zhu, J.; Zhu, K.; Zhu, K. J.; Zhu, S.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zou, B. S.; Zou, J. H.; Besiii Collaboration

2018-04-01

We search for rare decays of D mesons to hadrons accompanied by an electron-positron pair (h (h('))e+e-), using an e+e- collision sample corresponding to an integrated luminosity of 2.93 fb-1 collected with the BESIII detector at √{s }=3.773 GeV . No significant signals are observed, and the corresponding upper limits on the branching fractions at the 90% confidence level are determined. The sensitivities of the results are at the level of 10-5- 10-6 , providing a large improvement over previous searches.

Search for the rare decays D → h ( h ( ' ) ) e + e -

DOE PAGES

Ablikim, M.; Achasov, M. N.; Ahmed, S.; ...

2018-04-27

We search for rare decays of D mesons to hadrons accompanied by an electron-positron pair (h(h ('))e +e -), using an e +e - collision sample corresponding to an integrated luminosity of 2.93 fb -1 collected with the BESIII detector at √ s = 3.773 GeV . No significant signals are observed, and the corresponding upper limits on the branching fractions at the 90% confidence level are determined. The sensitivities of the results are at the level of 10 -5 –10 -6, providing a large improvement over previous searches.

Search for the rare decays D → h ( h ( ' ) ) e + e -

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ablikim, M.; Achasov, M. N.; Ahmed, S.

We search for rare decays of D mesons to hadrons accompanied by an electron-positron pair (h(h ('))e +e -), using an e +e - collision sample corresponding to an integrated luminosity of 2.93 fb -1 collected with the BESIII detector at √ s = 3.773 GeV . No significant signals are observed, and the corresponding upper limits on the branching fractions at the 90% confidence level are determined. The sensitivities of the results are at the level of 10 -5 –10 -6, providing a large improvement over previous searches.

The polymorphic aggregative phenotype of Shiga toxin-producing Escherichia coli O111 depends on rpoS and curli

USDA-ARS?s Scientific Manuscript database

Escherichia coli O111 is an emerging non-O157:H7 Shiga toxin-producing E. coli (STEC). We previously reported that outbreak and environmental, but not sporadic case, strains of STEC O111 share a distinct aggregation phenotype (M. E. Diodati, A. H. Bates, M. B. Cooley, S. Walker, R. E. Mandrell, and ...

The MIT - Cornell Collision and Why it Happened

DTIC Science & Technology

2008-10-01

George Boulevard Ben and Team UCF’s Knight Rider Section 2.2 2h00m North Nevada and Red Zone CarOLO’s Caroline turns across MIT’s Talos Section 2.3...3h00m White Zone Caroline and Talos collide. Section 2.4 4h00m Carolina Avenue and Texas Avenue Talos swerves to avoid Victor Tango’s Odin Section 2.5...stopped in time to prevent a collision. 2.3 Caroline and Talos at North Nevada and Red Zone N or th N ev ad a Av e C ar ol in a Av e Red Zone

Stochastic Navier-Stokes Equations in Unbounded Channel Domains (Open Source)

DTIC Science & Technology

2014-09-17

0 (Θ) = The space of all infinitely differentiable vector fields with compact support in Θ, W0(Θ) = The completion of C∞0 (Θ) vector fields in the...us use the differentiability of K(y, t) in time t. For |h| < η, we have E [( w1(y, t+ h, ω)− w1(y, t, ω) h − w1t(y, t, ω) )2 ] = E [∫ t 0 ( K(y, t+ h...s, ω) → K(y, 0)f(t, ω) = f(t, ω). Thus by the Lebesgue’s differentiation theorem (Theorem 6, Appendix E.4 of Evans [21]), the last term of the right

Automation of the Marine Corps Planning Process

DTIC Science & Technology

2014-06-01

I & IV P ro b le m Fr am in g C h ap te r II  JT C W  C P O F  IO Sv 1 C O A D e ve lo p m e n t C O A W ar -G am e C O A C o m p...S  JA D IC S  P SS -S O F  St ri ke Li n k  C ID N E  IO Sv 2  IO Sv 3  M ar in e Li n k Command & Control C h ap te r II I

Joint Project Manager (JPM) Chemical Biological Individual and Collective Protection Industry Day

DTIC Science & Technology

2008-07-22

ANSWER: The SBA operates the Office of Women’s B i O hi Th OWBO t thus ness wners p. e promo es e growth of women owned businesses through programs...TIC prioritization focused on a h i i k t f h tcompre ens ve r s managemen o w a we do not know: Absolute global production levels Absolute global...Modeling (For operational analyses) 2. Breakthrough Levels 3 D t ti A h. e ec on pproac es Multiple species may be present 4. Chemical Class Analysis

Response Protocol Toolbox: Planning for and Responding to Drinking Water Contamination Threats and Incidents. Response Guidelines

DTIC Science & Technology

2004-08-01

sp ec if ic ra d io n u cl id es 9 0 0 S er ie s 3 2 In te ri m F in al – A u g u st 2 0 0 4 R E S...in je ct io n , h ea d sp ac e S ee M o d u le 4 A n a ly si s: G C /M S , G C , H P L C , L C -M S U n k n o w n in o rg an ic s 1 L...er f o r th e m et er o r k it u se d d u ri n g s

Hydrogen-induced structural transition in single layer ReS2

NASA Astrophysics Data System (ADS)

Yagmurcukardes, M.; Bacaksiz, C.; Senger, R. T.; Sahin, H.

2017-09-01

By performing density functional theory-based calculations, we investigate how structural, electronic and mechanical properties of single layer ReS2 can be tuned upon hydrogenation of its surfaces. It is found that a stable, fully hydrogenated structure can be obtained by formation of strong S-H bonds. The optimized atomic structure of ReS2H2 is considerably different than that of the monolayer ReS2 which has a distorted-1T phase. By performing phonon dispersion calculations, we also predict that the Re2-dimerized 1T structure (called 1T {{}\\text{R{{\\text{e}}2}}} ) of the ReS2H2 is dynamically stable. Unlike the bare ReS2 the 1T {{}\\text{R{{\\text{e}}2}}} -ReS2H2 structure which is formed by breaking the Re4 clusters into separated Re2 dimers, is an indirect-gap semiconductor. Furthermore, mechanical properties of the 1T {{}\\text{R{{\\text{e}}2}}} phase in terms of elastic constants, in-plane stiffness (C) and Poisson ratio (ν) are investigated. It is found that full hydrogenation not only enhances the flexibility of the single layer ReS2 crystal but also increases anisotropy of the elastic constants.

H.E.S.S. discovery of VHE γ-rays from the quasar PKS 1510-089

NASA Astrophysics Data System (ADS)

H.E.S.S. Collaboration; Abramowski, A.; Acero, F.; Aharonian, F.; Akhperjanian, A. G.; Anton, G.; Balenderan, S.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker Tjus, J.; Behera, B.; Bernlöhr, K.; Birsin, E.; Biteau, J.; Bochow, A.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Carrigan, S.; Casanova, S.; Cerruti, M.; Chadwick, P. M.; Chaves, R. C. G.; Cheesebrough, A.; Colafrancesco, S.; Cologna, G.; Conrad, J.; Couturier, C.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; deWilt, P.; Dickinson, H. J.; Djannati-Ataï, A.; Domainko, W.; O'C. Drury, L.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Egberts, K.; Eger, P.; Espigat, P.; Fallon, L.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Gast, H.; Giebels, B.; Glicenstein, J. F.; Glück, B.; Göring, D.; Grondin, M.-H.; Grudzińska, M.; Häffner, S.; Hague, J. D.; Hahn, J.; Hampf, D.; Harris, J.; Hauser, M.; Heinz, S.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; Jahn, C.; Jamrozy, M.; Jung, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Khélifi, B.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kneiske, T.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Kossakowski, R.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lefaucheur, J.; Lemoine-Goumard, M.; Lenain, J.-P.; Lennarz, D.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Masbou, J.; Maurin, G.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Medina, M. C.; Méhault, J.; Menzler, U.; Moderski, R.; Mohamed, M.; Moulin, E.; Naumann, C. L.; Naumann-Godo, M.; de Naurois, M.; Nedbal, D.; Nguyen, N.; Niemiec, J.; Nolan, S. J.; Ohm, S.; de Oña Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Raue, M.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Ripken, J.; Rob, L.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sheidaei, F.; Skilton, J. L.; Sol, H.; Spengler, G.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Szostek, A.; Tavernet, J.-P.; Terrier, R.; Tluczykont, M.; Trichard, C.; Valerius, K.; van Eldik, C.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Völk, H. J.; Volpe, F.; Vorobiov, S.; Vorster, M.; Wagner, S. J.; Ward, M.; White, R.; Wierzcholska, A.; Wouters, D.; Zacharias, M.; Zajczyk, A.; Zdziarski, A. A.; Zech, A.; Zechlin, H. S.

2013-06-01

The quasar PKS 1510-089 (z = 0.361) was observed with the H.E.S.S. array of imaging atmospheric Cherenkov telescopes during high states in the optical and GeV bands, to search for very high energy (VHE, defined as E ≥ 0.1 TeV) emission. VHE γ-rays were detected with a statistical significance of 9.2 standard deviations in 15.8 h of H.E.S.S. data taken during March and April 2009. A VHE integral flux of I(0.15 TeV < E < 1.0 TeV)= (1.0 ± 0.2stat ± 0.2sys) × 10-11 cm-2 s-1 is measured. The best-fit power law to the VHE data has a photon index of Γ = 5.4 ± 0.7stat ± 0.3sys. The GeV and optical light curves show pronounced variability during the period of H.E.S.S. observations. However, there is insufficient evidence to claim statistically significant variability in the VHE data. Because of its relatively high redshift, the VHE flux from PKS 1510-089 should suffer considerable attenuation in the intergalactic space due to the extragalactic background light (EBL). Hence, the measured γ-ray spectrum is used to derive upper limits on the opacity due to EBL, which are found to be comparable with the previously derived limits from relatively-nearby BL Lac objects. Unlike typical VHE-detected blazars where the broadband spectrum is dominated by nonthermal radiation at all wavelengths, the quasar PKS 1510-089 has a bright thermal component in the optical to UV frequency band. Among all VHE detected blazars, PKS 1510-089 has the most luminous broad line region. The detection of VHE emission from this quasar indicates a low level of γ - γ absorption on the internal optical to UV photon field.

Vaccination with Killed but Metabolically Active E. coli Over-expressing Hemagglutinin Elicits Neutralizing Antibodies to H1N1 Swine Origin Influenza A Virus

PubMed Central

Liu, Pei-Feng; Wang, Yanhan; Liu, Yu-Tsueng; Huang, Chun-Ming

2017-01-01

There is a need for a fast and simple method for vaccine production to keep up with the pace of a rapidly spreading virus in the early phases of the influenza pandemic. The use of whole viruses produced in chicken eggs or recombinant antigens purified from various expression systems has presented considerable challenges, especially with lengthy processing times. Here, we use the killed but metabolically active (KBMA) Escherichia coli (E. coli) to harbor the hemagglutinin (HA) of swine origin influenza A (H1N1) virus (S-OIV) San Diego/01/09 (SD/H1N1-S-OIV). Intranasal vaccination of mice with KBMA E. coli SD/H1N1-S-OIV HA without adding exogenous adjuvants provoked detectable neutralizing antibodies against the virus-induced hemagglutination within three weeks. Boosting vaccination enhanced the titers of neutralizing antibodies, which can decrease viral infectivity in Madin-Darby canine kidney (MDCK) cells. The antibodies were found to specifically neutralize the SD/H1N1-S-OIV-, but not seasonal influenza viruses (H1N1 and H3N2), -induced hemagglutination. The use of KBMA E. coli as an egg-free system to produce anti-influenza vaccines makes unnecessary the rigorous purification of an antigen prior to immunization, providing an alternative modality to combat influenza virus in future outbreaks. PMID:28492063

HESS J1741-302: a hidden accelerator in the Galactic plane

NASA Astrophysics Data System (ADS)

H.E.S.S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Angüner, E. O.; Arakawa, M.; Armand, C.; Arrieta, M.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Becker Tjus, J.; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bonnefoy, S.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Capasso, M.; Caroff, S.; Carosi, A.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Colafrancesco, S.; Condon, B.; Conrad, J.; Davids, I. D.; Decock, J.; Deil, C.; Devin, J.; Dewilt, P.; Dirson, L.; Djannati-Ataï, A.; Donath, A.; Drury, L. O.'c.; Dyks, J.; Edwards, T.; Egberts, K.; Emery, G.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Funk, S.; Füßling, M.; Gabici, S.; Gallant, Y. A.; Garrigoux, T.; Gaté, F.; Giavitto, G.; Glawion, D.; Glicenstein, J. F.; Gottschall, D.; Grondin, M.-H.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holch, T. L.; Holler, M.; Horns, D.; Ivascenko, A.; Iwasaki, H.; Jacholkowska, A.; Jamrozy, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katsuragawa, M.; Katz, U.; Kerszberg, D.; Khangulyan, D.; Khélifi, B.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Komin, Nu.; Kosack, K.; Krakau, S.; Kraus, M.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lefaucheur, J.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Malyshev, D.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morå, K.; Moulin, E.; Murach, T.; Nakashima, S.; De Naurois, M.; Ndiyavala, H.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poireau, V.; Prokhorov, D. A.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Rauth, R.; Reimer, A.; Reimer, O.; Renaud, M.; De Los Reyes, R.; Rieger, F.; Rinchiuso, L.; Romoli, C.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Saito, S.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Shiningayamwe, K.; Simoni, R.; Sol, H.; Spanier, F.; Spir-Jacob, M.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Steppa, C.; Sushch, I.; Takahashi, T.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tsirou, M.; Tsuji, N.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zaborov, D.; Zacharias, M.; Zanin, R.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Zorn, J.; Żywucka, N.; NANTEN Collaboration; Enokiya, R.; Fukui, Y.; Hayakawa, T.; Okuda, T.; Torii, K.; Yamamoto, H.

2018-04-01

The H.E.S.S. Collaboration has discovered a new very high energy (VHE, E > 0.1 TeV) γ-ray source, HESS J1741-302, located in the Galactic plane. Despite several attempts to constrain its nature, no plausible counterpart has been found so far at X-ray and MeV/GeV γ-ray energies, and the source remains unidentified. An analysis of 145-h of observations of HESS J1741-302 at VHEs has revealed a steady and relatively weak TeV source ( 1% of the Crab Nebula flux), with a spectral index of Γ = 2.3 ± 0.2stat ± 0.2sys, extending to energies up to 10 TeV without any clear signature of a cut-off. In a hadronic scenario, such a spectrum implies an object with particle acceleration up to energies of several hundred TeV. Contrary to most H.E.S.S. unidentified sources, the angular size of HESS J1741-302 is compatible with the H.E.S.S. point spread function at VHEs, with an extension constrained to be below 0.068° at a 99% confidence level. The γ-ray emission detected by H.E.S.S. can be explained both within a hadronic scenario, due to collisions of protons with energies of hundreds of TeV with dense molecular clouds, and in a leptonic scenario, as a relic pulsar wind nebula, possibly powered by the middle-aged (20 kyr) pulsar PSR B1737-30. A binary scenario, related to the compact radio source 1LC 358.266+0.038 found to be spatially coincident with the best fit position of HESS J1741-302, is also envisaged.

HESS J1741-302: a hidden accelerator in the Galactic plane

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdalla, H.; Abramowski, A.; Aharonian, F.

The H.E.S.S. Collaboration has discovered a new very high energy (VHE, E > 0.1 TeV) γ-ray source, HESS J1741-302, located in the Galactic plane. Despite several attempts to constrain its nature, no plausible counterpart has been found so far at X-ray and MeV/GeV γ-ray energies, and the source remains unidentified. An analysis of 145-h of observations of HESS J1741-302 at VHEs has revealed a steady and relatively weak TeV source (~1% of the Crab Nebula flux), with a spectral index of Γ = 2.3 ± 0.2stat ± 0.2sys, extending to energies up to 10 TeV without any clear signature ofmore » a cut-off. In a hadronic scenario, such a spectrum implies an object with particle acceleration up to energies of several hundred TeV. Contrary to most H.E.S.S. unidentified sources, the angular size of HESS J1741-302 is compatible with the H.E.S.S. point spread function at VHEs, with an extension constrained to be below 0.068° at a 99% confidence level. The γ-ray emission detected by H.E.S.S. can be explained both within a hadronic scenario, due to collisions of protons with energies of hundreds of TeV with dense molecular clouds, and in a leptonic scenario, as a relic pulsar wind nebula, possibly powered by the middle-aged (20 kyr) pulsar PSR B1737-30. A binary scenario, related to the compact radio source 1LC 358.266+0.038 found to be spatially coincident with the best fit position of HESS J1741-302, is also envisaged.« less

HESS J1741-302: a hidden accelerator in the Galactic plane

DOE PAGES

Abdalla, H.; Abramowski, A.; Aharonian, F.; ...

2018-04-01

The H.E.S.S. Collaboration has discovered a new very high energy (VHE, E > 0.1 TeV) γ-ray source, HESS J1741-302, located in the Galactic plane. Despite several attempts to constrain its nature, no plausible counterpart has been found so far at X-ray and MeV/GeV γ-ray energies, and the source remains unidentified. An analysis of 145-h of observations of HESS J1741-302 at VHEs has revealed a steady and relatively weak TeV source (~1% of the Crab Nebula flux), with a spectral index of Γ = 2.3 ± 0.2stat ± 0.2sys, extending to energies up to 10 TeV without any clear signature ofmore » a cut-off. In a hadronic scenario, such a spectrum implies an object with particle acceleration up to energies of several hundred TeV. Contrary to most H.E.S.S. unidentified sources, the angular size of HESS J1741-302 is compatible with the H.E.S.S. point spread function at VHEs, with an extension constrained to be below 0.068° at a 99% confidence level. The γ-ray emission detected by H.E.S.S. can be explained both within a hadronic scenario, due to collisions of protons with energies of hundreds of TeV with dense molecular clouds, and in a leptonic scenario, as a relic pulsar wind nebula, possibly powered by the middle-aged (20 kyr) pulsar PSR B1737-30. A binary scenario, related to the compact radio source 1LC 358.266+0.038 found to be spatially coincident with the best fit position of HESS J1741-302, is also envisaged.« less

Comprehensive High School Bilingual Program. E.S.E.A. Title VII Final Evaluation Report, 1980-1981.

ERIC Educational Resources Information Center

Shore, Rima, Ed.; And Others

This report describes, provides demographic data for, and evaluates the effectiveness of the Comprehensive High School Bilingual Program (C.H.S.B.P.), which provided staff and material resources to five high school Spanish, Chinese, and Italian bilingual programs in New York City. In 1980-81, C.H.S.B.P. served 468 students of limited English…

INFLAMMATORY DISORDERS ASSOCIATED WITH HELICOBACTER PYLORI IN THE ROUX-EN-Y BYPASS GASTRIC POUCH.

PubMed

Chaves, Luiz Claudio Lopes; Borges, Isabela Klautau Leite Chaves; Souza, Maíra Danielle Gomes de; Silva, Ian Passos; Silva, Lyz Bezerra; Magalhães, Marcelo Alexandre Prado; Fonseca, Allan Herbert Feliz; Campos, Josemberg Marins

The prevalence of Helicobacter pylori in obese candidates for bariatric surgery and its role in the emergence of inflammatory lesions after surgery has not been well established. To identify the incidence of inflammatory lesions in the stomach after bariatric surgery and to correlate it with H. pylori infection. This is a prospective study with 216 patients undergoing Roux-en-Y gastric bypass. These patients underwent histopathological endoscopy to detect H. pylori prior to surgery. Positive cases were treated with antibiotics and a proton inhibitor pump followed by endoscopic follow-up in the 6th and 12th month after surgery. Most patients were female (68.1%), with grade III obesity (92.4%). Preoperative endoscopy revealed gastritis in 96.8%, with H. pylori infection in 40.7% (88/216). A biopsy was carried out in 151 patients, revealing H. pylori in 60/151, related to signs of inflammation in 90% (54/60). In the 6th and 12th month after surgery, the endoscopy and the histopathological exam showed a normal gastric pouch in 84% of patients and the incidence of H. pylori was 11% and 16%, respectively. The presence of inflammation was related to H. pylori infection (p<0,001). H. pylori has a similar prevalence in both obese patients scheduled to undergo bariatric surgery and the general population. There is a low incidence of it in the 6th and 12th months after surgery, probably owing to its eradication when detected prior to surgery. When inflammatory disease is present in the new gastric reservoir it is directly related to H. pylori infection. Helicobacter pylori é responsável por várias doenças gastrointestinais. Com o aumento de cirurgia bariátrica no país, há poucos estudos sobre a prevalência desta bactéria em obesos com indicação cirúrgica e o seu papel no surgimento de lesões inflamatórias no pós-operatório. Identificar a incidência de lesões inflamatórias no estômago pós-cirurgia bariátrica e correlacionar com a infecção por H. pylori. Estudo prospectivo com dois grupos de pacientes. Em ambos os grupos verificou-se a prevalência do H. pylori no pré-operatório através de histopatologia, mas em apenas um dos grupos, nos casos de H. pylori positivo realizou-se o tratamento com antibioticoterapia e inibidor de bomba de próton com realização de nova endoscopia no 6° e 12° mês pós-operatório. Avaliou-se 216 pacientes, com as seguintes características: sexo feminino (68,1%), faixa etária entre 30-40 anos, com 31,9% e 31%, respectivamente. De acordo com o IMC, 17,6% apresentavam obesidade moderada, 82,4% obesidade severa/mórbida e 9,7% superobesidade. Nos pacientes submetidos à endoscopia, a positividade do H. pylori se manifestou em 40,7%, sendo responsável pela atividade inflamatória na mucosa gástrica (p<0,001). No pós-operatório, investigou-se a mucosa gástrica através de endoscopia e histopatologia no 6° e 12° mês, que demonstrou normalidade no neorreservatorio gástrico em 84% dos pacientes, e a incidência de H. pylori foi 11% aos seis meses e 16% aos 12 meses, sendo a presença de processo inflamatório relacionado com a infecção pela bactéria (p<0,001). - H. pylori apresenta prevalência similar tanto em obesos que irão submeter-se à cirurgia bariátrica quanto à população em geral; há baixa incidência dele no 6° e 12° mês após a operação e isto deve-se provavelmente à sua erradicação quando detectado no pré-operatório; quando presente a doença inflamatória no neorreservatório gástrico possui relação direta com a infecção por H. pylori.

Enduring Strategic Rivalries

DTIC Science & Technology

2014-08-01

I N S T I T U T E F O R D E F E N S E A N A L Y S E S August 2014 Approved for public release; distribution is unlimited. IDA Paper P-5178 Log: H...license under the clause at DFARS 252.227-7013 (a)(16) [Jun 2013] I N S T I T U T E F O R D E F E N S E A N A L Y S E S IDA Paper P-5178 Enduring...City and its Countryside (London: G. Phillip, 1987), 75-81. 9 See John S. Morrison, John F. Coates, and N . Boris Rankov, The Athenian Trireme: The

DOE Research and Development Accomplishments Site Index (A-Z)

Science.gov Websites

dropdown arrow Site Map A-Z Index Menu Synopsis A - Z Index A B C D E F G H I J K L M N O P Q R S T U V W X Buckminsterfullerene Curl Smalley Buckyball Curl Smalley TOP A B C D E F G H I J K L M N O P Q R S T U V W X Y Z C transcription Dresselhaus, Mildred (Millie) Drosophila dynamics TOP A B C D E F G H I J K L M N O P Q R S T U V

The Effects of Antioxidants and Experience on the Development of Age Dependent Cognitive Dysfunction and Neuropathology in Canines

DTIC Science & Technology

2001-10-01

Douglas, H. Murphey, B.A. Muggenburg, S. Zicker , and N.W. Milgram. The effects of experience and antioxidants on size discrimination learning in the dog...submission: Appendix F. N.W. Milgram, S.C. Zicker , E. Head, B.A. Muggenburg, H. Murphey, C. Ikeda-Douglas, and C.W. Cotman. Dietary enrichment...dysfunction in canines N.W. Milgram,1* S.C. Zicker ,2 E. Head,3 B. A.Muggenburg,4 H. Murphey,4 C. Ikeda-Douglas’, and C.W. Cotman 3 ’Life Science Division

Gradientes de abundâncias em galáxias espirais

NASA Astrophysics Data System (ADS)

Dors, O. L.., Jr.; Copetti, M. V. F.

2003-08-01

Gradientes de abundâncias obtidos através de observações de regiões H II têm um papel importante no estudo de formação e evolução de galáxias espirais. Determinações diretas de abundâncias somente são obtidas quando linhas de emissão sensíveis à temperatura eletrônica (e.g., [O III]l4363) são detectadas. Infelizmente estas linhas são fracas ou não observadas em regiões H II de baixa excitação. Nestes casos métodos empíricos são utilizados para estimar as abundâncias químicas. Entretanto, diferentes métodos têm produzido diferentes estimativas de gradientes de abundâncias. Neste trabalho, nós construímos modelos de fotoionização com o objetivo de descrever diagramas de diagnósticos construídos com dados publicados de algumas galáxias espirais normais e barradas. Comparações entre nossas estimativas de abundâncias e de outros métodos mostram que quando não há acordo entre eles, nossos modelos superestimam as abundâncias de O/H e N/H por um fator de 0.3 dex em relação a estimativas diretas de abundâncias, e por fator de 0.2 dex em relação a outros métodos empíricos. A origem da produção de nitrogênio nas galáxias estudadas é discutida.

On the interconnection between Natural Time and Network Theory as a tool for predicting extreme events in seismology

NASA Astrophysics Data System (ADS)

Sarlis, N. V.; Skordas, E. S.; Varotsos, P.

2009-12-01

A new time domain, termed natural time χ, has been introduced by the authors[1]. This enables, among others, the distinction of Seismic Electric Signals (SES), which are low frequency geoelectric signals (≤1Hz) characterized by critical dynamics and precede earthquakes, from noise emitted from human made sources[2]. If one analyzes in natural time the seismicity subsequent to the SES by using an appropriately constructed network of earthquakes, the time of the impending mainshock can be identified within a few days[3-8]. The values of natural time specify the nodes of this network. Examples are presented, which include the prediction of the largest earthquake that occurred in Greece during the last twenty five years [9]. These examples provide evidence that natural time in conjunction with network theory is beneficial for the prediction of extreme events in seismology[3-6,8] and volcanology[7]. References: [1] P.A. Varotsos, N.V. Sarlis, and E.S. Skordas, Phys. Rev. E 66 , 011902 (2002). [2] P.A. Varotsos, N.V. Sarlis, and E.S. Skordas, Phys. Rev. E 67 , 021109 (2003); 68 , 031106 (2003); Phys. Rev. Lett. 91, 148501(2003). [3] P.A. Varotsos, N.V. Sarlis, H.K. Tanaka, and E.S. Skordas, Phys. Rev. E 72, 041103 (2005). [4] P. A. Varotsos, N. V. Sarlis, E. S. Skordas, H. K. Tanaka, and M. S. Lazaridou, Phys. Rev. E 73 , 031114 (2006); 74 , 021123 (2006). [5] P. A. Varotsos, N. V. Sarlis, E. S. Skordas, and M. S. Lazaridou, J. Appl. Phys. 103 , 014906 (2008). [6] N. V. Sarlis, E. S. Skordas, M. S. Lazaridou, and P. A. Varotsos, Proc. Jpn. Acad., Ser. B: Phys. Biol. Sci. 84 , 331 (2008) [7] S. Uyeda, M. Kamogawa and H. Tanaka, J. Geophys. Res. 114, B02310 (2009). [8] P. A. Varotsos, N. V. Sarlis and E. S. Skordas, CHAOS 19 , 023114 (2009). [9] Uyeda, S., and Kamogawa, M. Eos Trans. AGU 89 , 363 (2008).

Remote Sensing of Crosswind Profiles Using the Correlation Slope Method.

DTIC Science & Technology

1979-07-01

i s ‘What is the aeceptab it’ upper 1 int l t on ~ ~ca 11 i t 4 1 or w h i cli the i n v e r s i o n works in the noi seless case ?” In order to...ions in t h i s pape r . The b e h a v i o r of the pat h-we i g u t I ng fut te t i on W( • c i t s shoi ~t t iii I g . 2 t v a l u a t lOf l...1 Final Repsr~~ -~~ S. PV~~PO~ UWW O~~G; PORT NUMSEN • -S.--__ — - ~~. AUTHON(.) S. CONT R ACT ON GR ANT NUMSEN( . ) ,~ Ri~~~~ J~arakat/ Bolt

U.S. EPA, Pesticide Product Label, SANI-CLOTH PLUS GERMICIDAL DISPOSABLE CLOTH, 10/30/2007

EPA Pesticide Factsheets

2011-04-21

... Escherichia coli (E. coli) 0157:H7 (AIQGE~5Jj:5P) .... ... k1~~~g~:g~l~~I~r~;,'~ 1~~~~:e!g:'tEi#ure~"wiP.Ei!:c)~~b;s:;[~H~';iji~9J!Ii;~~] ...

Revealing the Effect of Irradiation on Cement Hydrates: Evidence of a Topological Self-Organization.

PubMed

Krishnan, N M Anoop; Wang, Bu; Sant, Gaurav; Phillips, James C; Bauchy, Mathieu

2017-09-20

Despite the crucial role of concrete in the construction of nuclear power plants, the effects of radiation exposure (i.e., in the form of neutrons) on the calcium-silicate-hydrate (C-S-H, i.e., the glue of concrete) remain largely unknown. Using molecular dynamics simulations, we systematically investigate the effects of irradiation on the structure of C-S-H across a range of compositions. Expectedly, although C-S-H is more resistant to irradiation than typical crystalline silicates, such as quartz, we observe that radiation exposure affects C-S-H's structural order, silicate mean chain length, and the amount of molecular water that is present in the atomic network. By topological analysis, we show that these "structural effects" arise from a self-organization of the atomic network of C-S-H upon irradiation. This topological self-organization is driven by the (initial) presence of atomic eigenstress in the C-S-H network and is facilitated by the presence of water in the network. Overall, we show that C-S-H exhibits an optimal resistance to radiation damage when its atomic network is isostatic (at Ca/Si = 1.5). Such an improved understanding of the response of C-S-H to irradiation can pave the way to the design of durable concrete for radiation applications.

JETCAL 2000R Analyzer H337PA-603 Operational Test and Evaluation (OT&E) on H-53 E/J Aircraft and H46 D/E Aircraft

DTIC Science & Technology

2003-01-28

Proposal Title PORTABLE TEST CELL - JETCAL 2000(R) Lead Proposer HOWELL INSTRUMENTS Military Customer NAVY/MARINE H53...B-4 Proposal Title PORTABLE TEST CELL - JETCAL 2000(R) Lead Proposer HOWELL INSTRUMENTS Military Customer...TEST CELL - JETCAL 2000(R) Lead Proposer HOWELL INSTRUMENTS Military Customer NAVY/MARINE H53 AIRCRAFT Baseline Costs -- DoD’s Costs When COSSI is NOT

Verification of Production Hole Quality. Volume 1

DTIC Science & Technology

1977-11-01

good metallurgical quality in that the surfaces...V < -< .. w / / ^1 -! .. 2 tf / / M O D E : A X IA F R E Q U E N C Y O R IE N T A T IO T E M P E R A T U n/ OJ / in o r | / / 0/ 0...i H / I 2 < 1. 1 u « 1 L Y S IS - O P - A X IA L S C • .0. u ^ 1 1 ^ 1 H 1 M 1 -1 1 n 1 1 0 <-

MTMC’s Approach to Reengineering DoD’s Personal Property Business Process.

DTIC Science & Technology

1996-01-01

Logistics Management Institute MTMG’s Approach to Reengineering DoD’s Personal Property Business Process MT502MR2 Alfred H.. Beyer James E...concerns, as expressed by business owners, senior executives, and managers during meetings, telephone conversations, and in correspondence, regarding... Business Process MT502MR2 Alfred H. Beyer James E. Cotterman Prepared pursuant to Department of Defense Contract DASW01-95-C-0019. The views

Mechanisms of Polymer Curing and Thermal Degradation

DTIC Science & Technology

1979-12-01

respectively. 29 0)- Fi . J . IR S e t u f i ( - 3 E hy y p e o y Ph n l S f n .30 z Iii 41 rI2P6i4000 3500 3000 42500 §200010 6010 2010 0 0 0 0...Polymer X Obs.6(_pm) Obs.(ppmA H 7.9,8.0 g,h 7.8 g,h 7.5 I ,e 7.5 i ,c,2 7.3 b,e 6.0-7.2 b,d,f,j,=CH 7.2 d 7.0 f,j 3.1 a HC C =- T O" 7.9 g 7.9 g 7.3 b...e 7.4 b,e 7.1 d 6.0-7.1 c,d,f,=CH 7.0 f,c 3.1 a 3.1 a aFor X 0 H, ggh, f= i b Based on first-order analysis of multiplets. 37 t TABLE 4. SUMMARY OF 13C

17 CFR 200.30-3 - Delegation of authority to Director of Division of Trading and Markets.

Code of Federal Regulations, 2011 CFR

2011-04-01

...(h) (§§ 240.14e-4(c), 240.14e-5(d), and 240.15c2-11(h) of this chapter), and Rules 101(d), 102(e...)(1)(viii)(G), § 240.15c3-1e(a)(1)(ix)(C), § 240.15c3-1e(a)(4), § 240.15c3-1g(b)(1)(i)(H), and § 240... Commission pursuant to sections 5318A(a)(4), 5318A(e)(2) and 5318(h)(2) of the Bank Secrecy Act (31 U.S.C...

Aircraft Landing Dynamic Analysis. Volume 1. Equations of Motion

DTIC Science & Technology

1987-11-09

aQh Xp* (WB 1I H 3 Hh pg esd r f, d X, r B dIp ~ b X aH Hf (a, B + b B 3 b) + F d el 1N + b 60 The fB 2 equation is fBEB N G B f2B (M )CS a 1, N ] B...1 a a TBB (A s a’ Ga 3bg a=I a ah a C + F Hb ( B/eB ) B d 6be d H c + e TBg C l e H e 3 Hh Pg esdr x f ?Hd (a r + b XBr) 8 s ) H 3 f TB 1 b VB BY + g...nondecreasing on [a,b] then f is g integrable on [a,b] (Reference (3)). This is denoted by Jb f dg. In the special case where g = I (the identity

32 CFR Appendix H to Part 323 - DLA Exemption Rules

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false DLA Exemption Rules H Appendix H to Part 323... PROGRAM DEFENSE LOGISTICS AGENCY PRIVACY PROGRAM Pt. 323, App. H Appendix H to Part 323—DLA Exemption...) through (4), (e)(1), (e)(4)(G), (H), and (I), and (f). 3. Authorities: 5 U.S.C. 552a(k)(2) and (k)(5). 4...

Bulletin of the American Astronomical Society. Volume 36, Number 1, 2004

DTIC Science & Technology

2004-01-01

A. S., Van Malderen, R., Uytterhoeven, K., Davignon, G., Dunham, E. W., Olkin , C. B., Taylor, B. W., Wasserman, L. H., Clancy, K., Person, M. J...Leggett, S. K., Levine, S. E., Moon, D.-S., Olkin , C. B., Osip, D. J., Pasachoff, J. M., Penprase, B. E., Person, M. J., Qu, S., Rayner, J. T., Rob...Moon, D.-S., Buie, M. W., Dunham, E. W., Olkin , C. B., Taylor, B., Kern, S. D., Qu, S., Salyk, C. V., Leggett, S. K., Levine, S. E., and Stone, R. C

Hydrogen collisions with transition metal surfaces: Universal electronically nonadiabatic adsorption

NASA Astrophysics Data System (ADS)

Dorenkamp, Yvonne; Jiang, Hongyan; Köckert, Hansjochen; Hertl, Nils; Kammler, Marvin; Janke, Svenja M.; Kandratsenka, Alexander; Wodtke, Alec M.; Bünermann, Oliver

2018-01-01

Inelastic scattering of H and D atoms from the (111) surfaces of six fcc transition metals (Au, Pt, Ag, Pd, Cu, and Ni) was investigated, and in each case, excitation of electron-hole pairs dominates the inelasticity. The results are very similar for all six metals. Differences in the average kinetic energy losses between metals can mainly be attributed to different efficiencies in the coupling to phonons due to the different masses of the metal atoms. The experimental observations can be reproduced by molecular dynamics simulations based on full-dimensional potential energy surfaces and including electronic excitations by using electronic friction in the local density friction approximation. The determining factors for the energy loss are the electron density at the surface, which is similar for all six metals, and the mass ratio between the impinging atoms and the surface atoms. Details of the electronic structure of the metal do not play a significant role. The experimentally validated simulations are used to explore sticking over a wide range of incidence conditions. We find that the sticking probability increases for H and D collisions near normal incidence—consistent with a previously reported penetration-resurfacing mechanism. The sticking probability for H or D on any of these metals may be represented as a simple function of the incidence energy, Ein, metal atom mass, M, and incidence angle, 𝜗i n. S =(S0+a ṡEi n+b ṡM ) *(1 -h (𝜗i n-c ) (1 -cos(𝜗 i n-c ) d ṡh (Ei n-e ) (Ei n-e ) ) ) , where h is the Heaviside step function and for H, S0 = 1.081, a = -0.125 eV-1, b =-8.40 ṡ1 0-4 u-1, c = 28.88°, d = 1.166 eV-1, and e = 0.442 eV; whereas for D, S0 = 1.120, a = -0.124 eV-1, b =-1.20 ṡ1 0-3 u-1, c = 28.62°, d = 1.196 eV-1, and e = 0.474 eV.

Converging shocks in elastic-plastic solids.

PubMed

Ortega, A López; Lombardini, M; Hill, D J

2011-11-01

We present an approximate description of the behavior of an elastic-plastic material processed by a cylindrically or spherically symmetric converging shock, following Whitham's shock dynamics theory. Originally applied with success to various gas dynamics problems, this theory is presently derived for solid media, in both elastic and plastic regimes. The exact solutions of the shock dynamics equations obtained reproduce well the results obtained by high-resolution numerical simulations. The examined constitutive laws share a compressible neo-Hookean structure for the internal energy e=e(s)(I(1))+e(h)(ρ,ς), where e(s) accounts for shear through the first invariant of the Cauchy-Green tensor, and e(h) represents the hydrostatic contribution as a function of the density ρ and entropy ς. In the strong-shock limit, reached as the shock approaches the axis or origin r=0, we show that compression effects are dominant over shear deformations. For an isothermal constitutive law, i.e., e(h)=e(h)(ρ), with a power-law dependence e(h) is proportional to ρ(α), shock dynamics predicts that for a converging shock located at r=R(t) at time t, the Mach number increases as M is proportional to [log(1/R)](α), independently of the space index s, where s=2 in cylindrical geometry and 3 in spherical geometry. An alternative isothermal constitutive law with p(ρ) of the arctanh type, which enforces a finite density in the strong-shock limit, leads to M is proportional to R(-(s-1)) for strong shocks. A nonisothermal constitutive law, whose hydrostatic part e(h) is that of an ideal gas, is also tested, recovering the strong-shock limit M is proportional to R(-(s-1)/n(γ)) originally derived by Whitham for perfect gases, where γ is inherently related to the maximum compression ratio that the material can reach, (γ+1)/(γ-1). From these strong-shock limits, we also estimate analytically the density, radial velocity, pressure, and sound speed immediately behind the shock. While the hydrostatic part of the energy essentially commands the strong-shock behavior, the shear modulus and yield stress modify the compression ratio and velocity of the shock far from the axis or origin. A characterization of the elastic-plastic transition in converging shocks, which involves an elastic precursor and a plastic compression region, is finally exposed.

Atomic Engineering of Superconductors by Design

DTIC Science & Technology

2014-10-23

Kumah, J. H. Ngai, E. D. Specht , D. A. Arena, F. J. Walker, C. H. Ahn. Phase diagram of compressively strained nickelate thin films, Applied Physics...1940 (2014)10.1002/adma.201304256). 3. A. S. Disa, D. P. Kumah, J. H. Ngai, E. D. Specht , D. A. Arena, F. J. Walker, C. H. Ahn, Phase diagram of

Unsaturated macrocyclic dihydroxamic acid siderophores produced by Shewanella putrefaciens using precursor-directed biosynthesis.

PubMed

Soe, Cho Z; Codd, Rachel

2014-04-18

To acquire iron essential for growth, the bacterium Shewanella putrefaciens produces the macrocyclic dihydroxamic acid putrebactin (pbH2; [M + H(+)](+), m/zcalc 373.2) as its native siderophore. The assembly of pbH2 requires endogenous 1,4-diaminobutane (DB), which is produced from the ornithine decarboxylase (ODC)-catalyzed decarboxylation of l-ornithine. In this work, levels of endogenous DB were attenuated in S. putrefaciens cultures by augmenting the medium with the ODC inhibitor 1,4-diamino-2-butanone (DBO). The presence in the medium of DBO together with alternative exogenous non-native diamine substrates, (15)N2-1,4-diaminobutane ((15)N2-DB) or 1,4-diamino-2(E)-butene (E-DBE), resulted in the respective biosynthesis of (15)N-labeled pbH2 ((15)N4-pbH2; [M + H(+)](+), m/zcalc 377.2, m/zobs 377.2) or the unsaturated pbH2 variant, named here: E,E-putrebactene (E,E-pbeH2; [M + H(+)](+), m/zcalc 369.2, m/zobs 369.2). In the latter system, remaining endogenous DB resulted in the parallel biosynthesis of the monounsaturated DB-E-DBE hybrid, E-putrebactene (E-pbxH2; [M + H(+)](+), m/zcalc 371.2, m/zobs 371.2). These are the first identified unsaturated macrocyclic dihydroxamic acid siderophores. LC-MS measurements showed 1:1 complexes formed between Fe(III) and pbH2 ([Fe(pb)](+); [M](+), m/zcalc 426.1, m/zobs 426.2), (15)N4-pbH2 ([Fe((15)N4-pb)](+); [M](+), m/zcalc 430.1, m/zobs 430.1), E,E-pbeH2 ([Fe(E,E-pbe)](+); [M](+), m/zcalc 422.1, m/zobs 422.0), or E-pbxH2 ([Fe(E-pbx)](+); [M](+), m/zcalc 424.1, m/zobs 424.2). The order of the gain in siderophore-mediated Fe(III) solubility, as defined by the difference in retention time between the free ligand and the Fe(III)-loaded complex, was pbH2 (ΔtR = 8.77 min) > E-pbxH2 (ΔtR = 6.95 min) > E,E-pbeH2 (ΔtR = 6.16 min), which suggests one possible reason why nature has selected for saturated rather than unsaturated siderophores as Fe(III) solubilization agents. The potential to conduct multiple types of ex situ chemical conversions across the double bond(s) of the unsaturated macrocycles provides a new route to increased molecular diversity in this class of siderophore.

Naval Postgraduate School Research. Volume 10, Number 2, June 2000

DTIC Science & Technology

2000-06-01

Associate Provost and Dean of Research Dr. David W. Netzer R E S E A R C H N A V A L P O S T G R A D U A T E S C H O O L Introduction The past two...capture during the execution phase of Fleet Battle Experiment Golf (FBE- G ). Fleet Battle Experiment Golf was conducted by Sixth Fleet and the Maritime...in FBE- G . The National Security Telecommunications and Information Systems Security Committee (NSTISSC) and the National Security Agency has certified

NRL (Naval Research Laboratory) Plasma Formulary. Revised.

DTIC Science & Technology

1983-01-01

EQUATIONS Name Rationalized inks Gaussian Faday’s law V xE -- !-s VxE--l1p .aD -l3D 4i" Ampere’slta xH-VxH -- +J VxH -- .- +- J at C at C Poison’s eqution...energy density Froude Fr t V (gL ) 1/2 (Inertial forces/gravitational or VINL buoyancy forces) t/2 Gay- Lussac Ga I/PA T (Relative volume change...112 Alfvin speed a Newton’s- law heat coefficient, k x " aA T aix Volumetric expansion coefficient, dV/ V - )dT r Bulk modulus (units m/it 2 ) AR, A

[The H+/e- ratio in the photosynthetic electron transport chain].

PubMed

Ivanov, B N; Shmeleva, V L; Ovchinnikova, V I

1983-06-01

The number of protons adsorbed by tylakoids during one electron passage along the photosynthetic electron transport chain (i.e. the H+/e- ratio) was measured in isolated pea chloroplasts upon continuous illumination. Methylviologen was used as electron acceptor on the reducing side of PS I. It was found that at pH 6.0 upon illumination with red light (lambda greater than 620 nm) at an intensity of 2 . 10(5) erg/cm2 . s ("intensive" light) the H+/e- ratio is equal to 3. Upon illumination of dark-adapted chloroplasts with a "weak" light (900 erg/cm2 . s) the H+/e- ratio is equal to 2. Upon illumination of the chloroplasts with a "weak" after "intensive" light the value of this ratio is close to 3. Azide when added to the reaction mixture may interfere with the accuracy of measurements of the value of the H+/e- ratio by affecting proton exchange. Based on the changes in the H+/e- ratio induced by illumination it was assumed that at saturating intensity of the illuminating light the electron transport chain passes into a so-called "light" state when the mechanisms of proton-electron coupling differing from those of rare electron transfer ("weak" light, flashes) are triggered on. At pH 6.0 the "light" state of the electron transport chain is maintained for some time in the dark.

Hiding in plain sight: immune evasion by the staphylococcal protein SdrE.

PubMed

Herr, Andrew B; Thorman, Alexander W

2017-05-10

The human immune system is responsible for identification and destruction of invader cells, such as the bacterial pathogen Staphylococcus aureus In response, S. aureus brings to the fight a large number of virulence factors, including several that allow it to evade the host immune response. The staphylococcal surface protein SdrE was recently reported to bind to complement Factor H, an important regulator of complement activation. Factor H attaches to the surface of host cells to inhibit complement activation and amplification, preventing the destruction of the host cell. SdrE binding to Factor H allows S. aureus to mimic a host cell and reduces bacterial killing by granulocytes. In a new study published in Biochemical Journal , Zhang et al. describe crystal structures of SdrE and its complex with the C-terminal portion of Factor H. The structure of SdrE and its interaction with the Factor H peptide closely resemble a family of surface proteins that recognize extracellular matrix components such as fibrinogen. However, unbound SdrE forms a novel 'Closed' conformation with an occluded peptide-binding groove. These structures reveal a fascinating mechanism for immune evasion and provide a potential avenue for the development of novel antimicrobial agents to target SdrE. © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society.

Reactive Removal of BiF Ground State

DTIC Science & Technology

1990-09-28

1978). 3. W E. Jones and T D. McLean, J. Mol. Spectrosc. 90, 481 (1981). 4. R. E Heidner, H . Helvajian , J. S. Holloway, and J. B. Koffend, J. Chem...Phys. 84, 2137 (1986). 5. C. R. Jones and H . P. Broida, J. Chem. Phys. 60, 4369 (1974). 6. H . Helvajian , J. S. Holloway, and J. B. Koffend, J. Chem...Phys. Rev. A6, 631 (1972). 27. H . Hotop and W C. Lineberger, J. Phys. Chem. Ref. Data 4, 539 (1985). 28. J.M. Herbelin, Conf. Proc., Intl. Gonf. on

Thermal detection of single e-h pairs in a biased silicon crystal detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romani, R. K.; Brink, P. L.; Cabrera, B.

We demonstrate that individual electron-hole pairs are resolved in a 1 cm 2 by 4 mm thick silicon crystal (0.93 g) operated at ~35 mK. One side of the detector is patterned with two quasiparticle-trap-assisted electro-thermal-feedback transition edge sensor arrays held near ground potential. The other side contains a bias grid with 20% coverage. Bias potentials up to ±160 V were used in the work reported here. A fiber optic provides 650 nm (1.9 eV) photons that each produce an electron-hole (e –h +) pair in the crystal near the grid. The energy of the drifting charges is measured withmore » a phonon sensor noise σ ~0.09 e – h + pair. In conclusion, the observed charge quantization is nearly identical for h +s or e –s transported across the crystal.« less

Thermal detection of single e-h pairs in a biased silicon crystal detector

DOE PAGES

Romani, R. K.; Brink, P. L.; Cabrera, B.; ...

2018-01-23

We demonstrate that individual electron-hole pairs are resolved in a 1 cm 2 by 4 mm thick silicon crystal (0.93 g) operated at ~35 mK. One side of the detector is patterned with two quasiparticle-trap-assisted electro-thermal-feedback transition edge sensor arrays held near ground potential. The other side contains a bias grid with 20% coverage. Bias potentials up to ±160 V were used in the work reported here. A fiber optic provides 650 nm (1.9 eV) photons that each produce an electron-hole (e –h +) pair in the crystal near the grid. The energy of the drifting charges is measured withmore » a phonon sensor noise σ ~0.09 e – h + pair. In conclusion, the observed charge quantization is nearly identical for h +s or e –s transported across the crystal.« less

Thermal detection of single e-h pairs in a biased silicon crystal detector

NASA Astrophysics Data System (ADS)

Romani, R. K.; Brink, P. L.; Cabrera, B.; Cherry, M.; Howarth, T.; Kurinsky, N.; Moffatt, R. A.; Partridge, R.; Ponce, F.; Pyle, M.; Tomada, A.; Yellin, S.; Yen, J. J.; Young, B. A.

2018-01-01

We demonstrate that individual electron-hole pairs are resolved in a 1 cm2 by 4 mm thick silicon crystal (0.93 g) operated at ˜35 mK. One side of the detector is patterned with two quasiparticle-trap-assisted electro-thermal-feedback transition edge sensor arrays held near ground potential. The other side contains a bias grid with 20% coverage. Bias potentials up to ±160 V were used in the work reported here. A fiber optic provides 650 nm (1.9 eV) photons that each produce an electron-hole (e- h+) pair in the crystal near the grid. The energy of the drifting charges is measured with a phonon sensor noise σ ˜0.09 e- h+ pair. The observed charge quantization is nearly identical for h+s or e-s transported across the crystal.

Total reaction cross sections of electronic state-specified transition metal cations: V + +C2H6, C3H8, and C2H4 at 0.2 eV

NASA Astrophysics Data System (ADS)

Sanders, Lary; Hanton, Scott D.; Weisshaar, James C.

1990-03-01

We describe a crossed beam experiment which measures total cross sections for reaction of electronic state-specified V+ with small hydrocarbons at well-defined collision energy E=0.2 eV. The V+ state distribution created at each ionizing wavelength is directly measured by angle-integrated photoelectron spectroscopy (preceding paper). Reactant and product ions are collected and analyzed by pulsed time-of-flight mass spectrometry following a reaction time of 6 μs. Tests of the performance of the apparatus are described in detail. Our experiment defines the reactant V+ electronic state distribution and the collision energy much more precisely than previous work. For all three hydrocarbons C2H6, C3H8, and C2H4, H2 elimination products dominate at 0.2 eV. We observe a dramatic dependence of cross section on the V+ electronic term. The second excited term 3d34s(3F) is more reactive than either lower energy quintet term 3d4(5D) or 3d34s(5F) by a factor of ≥270, 80, and ≥6 for the C2H6, C3H8, and C2H4 reactions, respectively. The 3d34s(3F) reaction cross sections at 0.2 eV are 20±11 Å2, 37±19 Å2, and 2.7±1.6 Å2, respectively, compared with Langevin cross sections of ˜80 Å2. For the C2H6 and C3H8 reactions, cross sections are independent of initial spin-orbit level J within the 3F term to the limits of our accuracy. Comparison with earlier work by Armentrout and co-workers shows that electronic excitation to d3s(3F) is far more effective at promoting H2 elimination than addition of the same total kinetic energy to reactants. Electron spin is clearly a key determinant of V+ reactivity with small hydrocarbons. We suggest that triplet V+ reacts much more efficiently than quintet V+ because of its ability to conserve total electron spin along paths to insertion in a C-H bond of the hydrocarbon.

Ordered to isotropic morphology transition in pattern-directed dewetting of polymer thin films on substrates with different feature heights.

PubMed

Roy, Sudeshna; Mukherjee, Rabibrata

2012-10-24

Controlled dewetting of a thin polymer film on a topographically patterned substrate is an interesting approach for aligning isotropic dewetted structures. In this article, we investigate the influence of substrate feature height (H(S)) on the dewetting pathway and final pattern morphology by studying the dewetting of polystyrene (PS) thin films on grating substrates with identical periodicity (λ(P) = 1.5 μm), but H(S) varying between 10 nm and 120 nm. We identify four distinct categories of final dewetted morphology, with different extent of ordering: (1) array of aligned droplets (H(S) ≈ 120 nm); (2) aligned undulating ribbons (H(S) ≈ 70-100 nm); (3) multilength scale structures with coexisting large droplets uncorrelated to the substrate and smaller droplets/ribbons aligned along the stripes (H(S) ≈ 40-60 nm); and (4) large droplets completely uncorrelated to the substrate (H(S) < 25 nm). The distinct morphologies across the categories are attributed to two major factors: (a) whether the as-cast film is continuous (H(S)≤ 80 nm) or discontinuous (H(S)≥ 100 nm) and (b) in case of a continuous film, whether the film ruptures along each substrate stripe (H(S)≥ 70 nm) or with nucleation of random holes that are not correlated to the substrate features (H(S)≤ 60 nm). While the ranges of H(S) values indicated in the parentheses are valid for PS films with an equivalent thickness (h(E)) ≈ 50.3 nm on a flat substrate, a change in h(E) merely alters the cut-off values of H(S), as the final dewetted morphologies and transition across categories remain generically unaltered. We finally show that the structures obtained by dewetting on different H(S) substrates exhibits different levels of hydrophobicity because of combined spatial variation of chemical and topographic contrast along the surface. Thus, the work reported in this article can find potential application in fabricating surfaces with controlled wettability.

Naval Space Forum. March-April 2010

DTIC Science & Technology

2010-04-01

of Dennis Tito, an U.S. businessman. In all, seven space tourists have made the journey, the latest, Canadian Guy Laliberte, founder of Cirque du ... Soleil , who flew to the space station in October. I R A N — I N F U S E D W I T H T H E I R O W N O R B I T A L P O T E N T I A L satnews.com

Reticulocyte hemoglobin measurement--comparison of two methods in the diagnosis of iron-restricted erythropoiesis.

PubMed

Thomas, Lothar; Franck, Susanne; Messinger, Maren; Linssen, Jo; Thomé, Marcus; Thomas, Christian

2005-01-01

The aims of this study were to diagnose iron-restricted erythropoiesis (functional iron deficiency) in patients with classic iron deficiency (ID), anemia of chronic disease (ACD) and the combined state of ID/ACD with the use of two hematological methods for the measurement of reticulocyte hemoglobinization. In comparison, the biochemical markers of iron status were determined. We studied 474 anemic patients admitted to hospital with a broad spectrum of diseases. We measured indicators of reticulocyte hemoglobinization. CHr was determined on an Advia 120 hematology analyzer. A Sysmex XE-2100 hematology analyzer was used to determine RET-Y, the forward scatter of fluorescence-labeled reticulocytes, which can also be expressed as the reticulocyte hemoglobin equivalent (RET-H(e)), as well as RBC-Y, the forward scatter of fluorescence-labeled erythrocytes, which can be expressed as the erythrocyte hemoglobin equivalent. Ferritin, soluble transferrin receptor (sTfR) and the sTfR/log ferritin ratio (sTfR-F index) were used as biochemical markers. The comparison of RET-Y with CHr demonstrated an excellent curvilinear relationship between the two parameters. The normal reference range for Ret-Y was 1630-1860 arbitrary units (AU); mathematical transformation to RET-H(e) gave a range of 28.2-35.7 pg. Correlations of biochemical iron markers with RET-H(e) were as weak as with CHr in patients with ACD and acute phase response. In a diagnostic plot to identify iron status, RET-H(e) could replace CHr without any loss of sensitivity or specificity. Patient mismatch analysis between RET-H(e) and CHr in the diagnostic plot demonstrated agreement for 449 of 474 patients (94.4%). Patient specific anemia mismatches were 2.9-6.2%. According to our results, the indicators of reticulocyte hemoglobinization, RET-H(e) and CHr, measure the same phenomenon. RET-H(e) is as valuable as CHr for the diagnosis of iron-restricted erythropoiesis. The combination of RET-H(e) and the sTfR-F index in a diagnostic plot offers an attractive tool for the evaluation of iron status and identification of the progression of ID.

Inactivation of Shiga toxin-producing Escherichia coli O104:H4 using cold atmospheric pressure plasma.

PubMed

Baier, Matthias; Janssen, Traute; Wieler, Lothar H; Ehlbeck, Jörg; Knorr, Dietrich; Schlüter, Oliver

2015-09-01

From cultivation to the end of the post-harvest chain, heat-sensitive fresh produce is exposed to a variety of sources of pathogenic microorganisms. If contaminated, effective gentle means of sanitation are necessary to reduce bacterial pathogen load below their infective dose. The occurrence of rare or new serotypes raises the question of their tenacity to inactivation processes. In this study the antibacterial efficiency of cold plasma by an atmospheric pressure plasma-jet was examined against the Shiga toxin-producing outbreak strain Escherichia coli O104:H4. Argon was transformed into non-thermal plasma at a power input of 8 W and a gas flow of 5 L min(-1). Basic tests were performed on polysaccharide gel discs, including the more common E. coli O157:H7 and non-pathogenic E. coli DSM 1116. At 5 mm treatment distance and 10(5) cfu cm(-2) initial bacterial count, plasma reduced E. coli O104:H4 after 60 s by 4.6 ± 0.6 log, E. coli O157:H7 after 45 s by 4.5 ± 0.6 log, and E. coli DSM 1116 after 30 s by 4.4 ± 1.1 log. On the surface of corn salad leaves, gentle plasma application at 17 mm reduced 10(4) cfu cm(-2) of E. coli O104:H4 by 3.3 ± 1.1 log after 2 min, whereas E. coli O157:H7 was inactivated by 3.2 ± 1.1 log after 60 s. In conclusion, plasma treatment has the potential to reduce pathogens such as E. coli O104:H4 on the surface of fresh produce. However, a serotype-specific adaptation of the process parameters is required. Copyright © 2015 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

H2S as an Indicator of Water Supply Vulnerability and Health Risk in Low-Resource Settings: A Prospective Cohort Study

PubMed Central

Khush, Ranjiv S.; Arnold, Benjamin F.; Srikanth, Padma; Sudharsanam, Suchithra; Ramaswamy, Padmavathi; Durairaj, Natesan; London, Alicia G.; Ramaprabha, Prabhakar; Rajkumar, Paramasivan; Balakrishnan, Kalpana; Colford Jr., John M.

2013-01-01

In this large-scale longitudinal study conducted in rural Southern India, we compared a presence/absence hydrogen sulfide (H2S) test with quantitative assays for total coliforms and Escherichia coli as measures of water quality, health risk, and water supply vulnerability to microbial contamination. None of the three indicators showed a significant association with child diarrhea. The presence of H2S in a water sample was associated with higher levels of total coliform species that may have included E. coli but that were not restricted to E. coli. In addition, we observed a strong relationship between the percent positive H2S test results and total coliform levels among water source samples (R2 = 0.87). The consistent relationships between H2S and total coliform levels indicate that presence/absence of H2S tests provide a cost-effective option for assessing both the vulnerability of water supplies to microbial contamination and the results of water quality management and risk mitigation efforts. PMID:23716404

International Hydrogenase Conference (7th) Held at the University of Reading on August 24th to 29th 2004.

DTIC Science & Technology

2004-08-19

Johannes Hackstein [ PB GIO rNovel Fe-hydrogenases from the rumen ciliate metagenome . :12.50 :114.00 -1 Lunch [ 114.00 1 7.00 1 Poster Session 2...d.r.o’ g’.e n-.a-.s.e..s from the rumnen ciliate metagenome . p36 Severing, E., Boxma, B., van Alen, T.A., Ricard, G., van Hoek, A.H.A.M., Moon-van...hydrogenases from the rumen ciliate metagenome . Severing, E.’, Boxma, B.1, van Alen, T.A.’, Ricard, G.z, van Hoek, A.H.A.M.’, Moon-van der Staay, S.Y

Preliminary Compositional Comparisons of H-Chondrite Falls to Antarctic H-Chondrite Populations

NASA Astrophysics Data System (ADS)

Kallemeyn, G. W.; Krot, A. N.; Rubin, A. E.

1993-07-01

In a series of papers [e.g., 1,2], Lipschutz and co-workers compared trace- element RNAA data from Antarctic and non-Antarctic H4-6 chondrites and concluded that the two populations have significantly different concentrations of several trace elements including Co, Se, and Sb. They interpreted their data as indicating that these Antarctic H chondrites form different populations than observed H falls and may have originated in separate parent bodies. Recent work by Sears and co-workers [e.g., 3] has shown that there seem to be distinct populations of Antarctic H chondrites, distinguishable on the bases of induced thermoluminescence (TL) peak temperature, metallographic cooling rate, and cosmic ray exposure age. They showed that a group of Antarctic H chondrites having abnormally high induced TL peak temperatures (>=190 degrees C) also has cosmic ray exposure ages <20 Ma (mostly ~8 Ma) and fast metallographic cooling rates (~100 K/Ma). Another group having induced TL peak temperatures <190 degrees C has exposure ages >20 Ma and slower cooling rates (~10-20 K/Ma). We studied 24 H4-6 chondrites from Victoria Land (including 12 previously analyzed by the Lipschutz group) by optical microscopy and electron microprobe. Many of the Antarctic H chondrites studied by Lipschutz and co- workers are unsuitable for proper compositional comparisons with H chondrite falls: Four are very weathered, five are extensively shocked, and two are extensively brecciated. Furthermore, at least five of the samples contain solar-wind gas (and hence are regolith breccias) [4]. These samples were rejected because of possible compositional modification by secondary processes. For our INAA study we chose a suite of relatively unweathered and unbrecciated Antarctic H chondrites (including nine from the Lipschutz set): ALHA 77294 (H5, S3); ALHA 79026 (H5, S3); ALHA 79039 (H5, S3); ALHA 80131 (H5, S3); ALHA 80132 (H5, S4); ALHA 81037 (H6, S3); EETA 79007 (H5, S4); LEW 85320 (H6, S4); LEW 85329 (H6, S3); RKPA 78002 (H5, S2); and RKPA 78004 (H4, S4). Single samples were each analyzed for 27 elements. Only four of our samples have been analyzed by TL. Concentrations of siderophile elements (Fe, Co, Ni, Ga, As, Au) in the Antarctic H chondrites tend to scatter more than those of 24 H falls studied in replicate at UCLA. This is probably due in part to the fact that replicate samples of the Antarctic chondrites have not yet been analyzed. The median concentrations of siderophile elements also tend to be slightly lower in Antarctic H chondrites, although 95% confidence intervals on the medians overlap with those of H falls for every element. Concentration ranges and median values of two chalcophile elements, Se and Zn, are nearly identical between the Antarctic H chondrites and H falls. Kolmogorov-Smirnov two-tailed tests on these elements show no significant differences between the two populations. Three of the elements analyzed in this study (Co, Se, Sb) are among those reported to vary significantly between Antarctic H chondrites and H falls by Dennison and Lipschutz [1], who found that median concentrations of these elements were slightly higher in Antarctic H chondrites. As noted earlier, we determined slightly lower median concentrations for Co and Sb in Antarctic H chondrites than in H falls; median Se concentrations were identical. The slightly lower median concentration values that we found for siderophile elements in general are probably indicative of a slight weathering loss of metal. Based on our compositional data, the Victoria Land H chondrites and non-Antarctic H falls do not require derivation from separate parent populations. References: [1] Dennison J. E. and Lipschutz M. E. (1987) GCA, 51, 741-754. [2] Lipschutz M. E. and Samuels S. M. (1991) GCA, 55, 19-34. [3] Benoit P. H. and Sears D. W. G. (1993) Icarus, 101, 188-200. [4] Schultz L. et al. (1991) GCA, 55, 59-66.

24 CFR 576.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 41403(6) of the Violence Against Women Act of 1994 (42 U.S.C. 14043e-2(6)), section 330(h)(5)(A) of the... the Violence Against Women Act of 1994 (42 U.S.C. 14043e-2), section 330(h) of the Public Health... disabilities, chronic physical health or mental health conditions, substance addiction, histories of domestic...

24 CFR 576.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 41403(6) of the Violence Against Women Act of 1994 (42 U.S.C. 14043e-2(6)), section 330(h)(5)(A) of the... the Violence Against Women Act of 1994 (42 U.S.C. 14043e-2), section 330(h) of the Public Health... disabilities, chronic physical health or mental health conditions, substance addiction, histories of domestic...

24 CFR 576.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 41403(6) of the Violence Against Women Act of 1994 (42 U.S.C. 14043e-2(6)), section 330(h)(5)(A) of the... the Violence Against Women Act of 1994 (42 U.S.C. 14043e-2), section 330(h) of the Public Health... disabilities, chronic physical health or mental health conditions, substance addiction, histories of domestic...

Fluorinated Materials for Air-stable and Moisture-resistant Flexible Optoelectronics

DTIC Science & Technology

2014-01-02

Kim Jong , H.; Shin, S.; Yang, H.; An, B.-K.; Yang, L.; Park Soo, Y. Adv Mater 2012, 24, 911-915; (c) Geng, Y.; Li, H.-B.; Wu, S.-X.; Su, Z.-M. J...Park, J.-U.; Shir, D. J.-L.; Nam , Y.-S.; Jeon, S.; Rogers, J. A. Chem. Rev. 2007, 107, 1117-1160; (g) Murphy, A. R.; Frechet, J. M. J. Chem. Rev. 2007...2649-2655; (w) Song, H.-J.; Kim , D.-H.; Lee, E.-J.; Heo, S.-W.; Lee, J.-Y.; Moon, D.-K. Macromolecules (Washington, DC, U. S.) 2012, 45, 7815- 7822; (x

In vitro evaluation of antimicrobial features of sugammadex.

PubMed

Hanci, Volkan; Vural, Ahmet; Hanci, Sevgi Yılmaz; Ali Kiraz, Hasan; Omür, Dilek; Unver, Ahmet

2014-01-01

Drugs administered by intravenous routes may be contaminated during several stages of production or preparation. Sugammadex is a modified gamma cyclodextrin. While research into the antibacterial effects of varieties of cyclodextrin is available, there are no studies focusing on the antibacterial effects of sugammadex. This study investigates the in vitro antimicrobial activity of sugammadex. The in vitro antimicrobial activity of sugammadex was investigated using the broth microdilution method. The pH of the test solution was determined using a pH meter. The test microorganisms included Staphylococcus aureus ATCC 29213, Enterococcus fecalis ATCC 29212, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853. In the second phase of the study 100mg/mL sugammadex (50μg) was contaminated with test microorganisms (50μg), including S. aureus ATCC 29213, E. fecalis ATCC 29212, E. coli ATCC 25922 and P. aeruginosa ATCC 27853, left to incubate for 24h and then the bacterial production in sugammadex was evaluated. The pH of the test solutions ranged between 7.25 and 6.97. Using the microdilution method, sugammadex had no antibacterial effect on S. aureus, E. fecalis, E. coli and P. aeruginosa at any concentration. In the second phase of the study bacterial production was observed after 24h in 100mg/mL sugammadex contaminated with the test microorganisms S. aureus, E. fecalis, E. coli and P. aeruginosa. Sugammadex had no antimicrobial effect on the test microorganisms, S. aureus, E. fecalis, E. coli and P. aeruginosa. Care should be taken that sterile conditions are maintained in the preparation of sugammadex; that the same sugammadex preparation not be used for more than one patient; and that storage conditions are adhered to after sugammadex is put into the injector. Copyright © 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

The near ultraviolet photodissociation dynamics of 2- and 3-substituted thiophenols: Geometric vs. electronic structure effects

NASA Astrophysics Data System (ADS)

Marchetti, Barbara; Karsili, Tolga N. V.; Cipriani, Maicol; Hansen, Christopher S.; Ashfold, Michael N. R.

2017-07-01

The near ultraviolet spectroscopy and photodissociation dynamics of two families of asymmetrically substituted thiophenols (2- and 3-YPhSH, with Y = F and Me) have been investigated experimentally (by H (Rydberg) atom photofragment translational spectroscopy) and by ab initio electronic structure calculations. Photoexcitation in all cases populates the 11ππ* and/or 11πσ* excited states and results in S-H bond fission. Analyses of the experimentally obtained total kinetic energy release (TKER) spectra yield the respective parent S-H bond strengths, estimates of ΔE(A ˜ -X ˜ ), the energy splitting between the ground (X ˜ ) and first excited (A ˜ ) states of the resulting 2-(3-)YPhS radicals, and reveal a clear propensity for excitation of the C-S in-plane bending vibration in the radical products. The companion theory highlights roles for both geometric (e.g., steric effects and intramolecular H-bonding) and electronic (i.e., π (resonance) and σ (inductive)) effects in determining the respective parent minimum energy geometries, and the observed substituent and position-dependent trends in S-H bond strength and ΔE(A ˜ -X ˜ ). 2-FPhSH shows some clear spectroscopic and photophysical differences. Intramolecular H-bonding ensures that most 2-FPhSH molecules exist as the syn rotamer, for which the electronic structure calculations return a substantial barrier to tunnelling from the photoexcited 11ππ* state to the 11πσ* continuum. The 11ππ* ← S0 excitation spectrum of syn-2-FPhSH thus exhibits resolved vibronic structure, enabling photolysis studies with a greater parent state selectivity. Structure apparent in the TKER spectrum of the H + 2-FPhS products formed when exciting at the 11ππ* ← S0 origin is interpreted by assuming unintended photoexcitation of an overlapping resonance associated with syn-2-FPhSH(v33 = 1) molecules. The present data offer tantalising hints that such out-of-plane motion influences non-adiabatic coupling in the vicinity of a conical intersection (between the 11πσ* and ground state potentials at extended S-H bond lengths) and thus the electronic branching in the eventual radical products.

Metabolism of dehydroepiandrosterone sulfate and estrone-sulfate by human platelets.

PubMed

Garrido, A; Munoz, Y; Sierralta, W; Valladares, L

2012-01-01

The aim of the present research was to study the uptake of DHEAS, and to establish the intracrine capacity of human platelets to produce sex steroid hormones. The DHEAS transport was evaluated through the uptake of [(3)H]-DHEAS in the presence or absence of different substrates through the organic anion transporting polypeptide (OATP) family. The activity of sulfatase enzyme was evaluated, and the metabolism of DHEAS was measured by the conversion of [(3)H]-DHEAS to [(3)H]-androstenedione, [(3)H]-testosterone, [(3)H]-estrone and [(3)H]-17beta-estradiol. Results indicated the existence in the plasma membrane of an OATP with high affinity for DHEAS and estrone sulphate (E(1)S). The platelets showed the capacity to convert DHEAS to active DHEA by the steroid-sulfatase activity. The cells resulted to be a potential site for androgens production, since they have the capacity to produce androstenedione and testosterone; in addition, they reduced [(3)H]-estrone to [(3)H]-17beta-estradiol. This is the first demonstration that human platelets are able to import DHEAS and E(1)S using the OATP family and to convert DHEAS to active DHEA, and to transform E(1)S to 17beta-estradiol.

Cation or Solvent-Induced Supermolecular Phthalocyanine Formation: Crown Ether Substituted Phthalocyanines.

DTIC Science & Technology

1987-06-01

38.) of slightly bluish green powder (Anal, see Table I). tH NMR(CDCl 3 ) 8.02(8H,s), 4.7-3.6(64H,m), - 3.41(2H,s). ZnCRPc was obtained by reaction of...J.P.; Bencosme, S.; Evitt, E., Sessler, J. Chem. Phys. 1984, 86, 161. Mialoco, C.; Giannotti, A., Maillard , P.; Momeuteau, M. Chem. Phys. Lett. 1984

Detection Performance of Horizontal Linear Hydrophone Arrays in Shallow Water.

DTIC Science & Technology

1980-12-15

random phase G gain G angle interval covariance matrix h processor vector H matrix matched filter; generalized beamformer I unity matrix 4 SACLANTCEN SR...omnidirectional sensor is h*Ph P G = - h [Eq. 47] G = h* Q h P s The following two sections evaluate a few examples of application of the OLP. Following the...At broadside the signal covariance matrix reduces to a dyadic: P 󈧬 s s*;therefore, the gain (e.g. Eq. 37) becomes tr(H* P H) Pn * -1 Q -1 Pn G ~OQp

Engineering of Yersinia Phytases to Improve Pepsin and Trypsin Resistance and Thermostability and Application Potential in the Food and Feed Industry.

PubMed

Niu, Canfang; Yang, Peilong; Luo, Huiying; Huang, Huoqing; Wang, Yaru; Yao, Bin

2017-08-30

Susceptibility to proteases usually limits the application of phytase. We sought to improve the pepsin and trypsin resistance of YeAPPA from Yersinia enterocolitica and YkAPPA from Y. kristensenii by optimizing amino acid polarity and charge. The predicted pepsin/trypsin cleavage sites F89/K226 in pepsin/trypsin-sensitive YeAPPA and the corresponding sites (F89/E226) in pepsin-sensitive but trypsin-resistant YkAPPA were substituted with S and H, respectively. Six variants were produced in Pichia pastoris for catalytic and biochemical characterization. F89S, E226H, and F89S/E226H elevated pepsin resistance and thermostability and K226H and F89S/K226H improved pepsin and trypsin resistance and stability at 60 °C and low pH. All the variants increased the ability of the proteins to hydrolyze phytate in corn meal by 2.6-14.9-fold in the presence of pepsin at 37 °C and low pH. This study developed a genetic manipulation strategy specific for pepsin/trypsin-sensitive phytases that can improve enzyme tolerance against proteases and heat and benefit the food and feed industry in a cost-effective way.

Mössbauer spectroscopy and DFT calculations on all protonation states of the 2Fe-2S cluster of the Rieske protein

NASA Astrophysics Data System (ADS)

Müller, C. S.; Auerbach, H.; Stegmaier, K.; Wolny, J. A.; Schünemann, V.; Pierik, A. J.

2017-11-01

The Thermus thermophilus Rieske protein ( TtRP) contains a 2Fe-2S cluster with one iron (Fe-Cys) coordinated by four sulfur atoms (2xS2- and 2xCys) and one iron (Fe-His) by two sulfur and two nitrogen atoms (2xS2-, His134 and His154). Here, the protein is investigated at three pH values (6.0, 8.5 and 10.5) in order to elucidate the protonation states of the His-ligands. Examination of the effect of protonation on the electronic structure of the cluster via Mössbauer spectroscopy gives a deeper understanding of the coupling of electron transfer to the protonation state of the His-ligands. Two components (1 referring to Fe-Cys and 2 to Fe-His) with parameters typical for a diamagnetic [2Fe-2S]2+ cluster are detected. The Mössbauer parameters and the protonation state clearly correlate: while δ remains almost pH-independent with δ 1 (pH6.0) = 0.23 (± 0.01) mms- 1 and δ 1 (pH10.5) = 0.24 (± 0.01) mms- 1 for Fe-Cys, it decreases for Fe-His from δ 2 (pH6.0) = 0.34 (± 0.01) mms- 1 to δ 2 (pH10.5) = 0.28 (± 0.01) mms- 1. Δ E Q changes from Δ E Q1 (pH6.0) = 0.57 (± 0.01) mms- 1 to Δ E Q1 (pH10.5) = 0.45 (± 0.01) mms- 1 and from Δ E Q2 (pH6.0) = 1.05 (± 0.01) mms- 1 to Δ E Q2 (pH10.5) = 0.71 (± 0.01) mms- 1. Density functional theory (DFT)-calculations based on the crystal structure (pdb 1NYK) (Hunsicker-Wang et al. Biochemistry 42, 7303, 2003) have been performed for the Rieske-cluster with different His-ligand protonation states, reproducing the experimentally observed trend.

Myocardial and lung injuries induced by hydrogen sulfide and the effectiveness of oxygen therapy in rats.

PubMed

Wu, Na; Du, Xuqin; Wang, Dixin; Hao, Fengtong

2011-03-01

To study myocardial and lung injuries initiated by hydrogen sulfide, and evaluate the role and effectiveness of normobaric and hyperbaric oxygen (HBO) treatment in rats. One hundred healthy male Wistar rats were randomly divided into five groups: A: Normal control group (no H2S); B: H2S-exposed group; C: H2S+33% oxygen treatment group; D: H2S+50% oxygen treatment group; E: H2S+HBO group. The rats in groups C, D and E were exposed to H2S in an exposure chamber (1 m3) and were made to inhale 300 ppm hydrogen sulfide for 60 min, and then they were subjected to normobaric or HBO therapy. Normobaric oxygen was at concentrations of 33% or 50%, HBO was for 100 min including compression and decompression; the rats in group A inhaled air under the same conditions. Blood was sampled immediately after the experiment for analysis of arterial blood gases, myocardial enzymes and cardiac troponin I. Lung was rapidly removed to be made into tissue homogenates and then cytochrome c oxidase activity was measured; myocardial and lung ultrastructural changes were observed by electron microscopy. Arterial blood gases: partial pressure of O2 (mmHg) (Group A, 97.6 ± 8.38; B, 76.5 ± 6.95*; C, 83.2 ± 2.66*; D, 86.20 ± 10.75*; E, 93.50 ± 4.97: *p < 0.01 compared to group A) was significantly lower than that in group in all but HBO rats. For myocardial enzymes and cardiac troponin I every parameter in groups B and C was significantly higher than that in group A (p<0.01),with no difference in D and E. Cytochrome c oxidase activity (u/mg) of lung tissue was reduced compared to group A after all treatments (A, 1.76 ± 0.02; B, 0.36 ± 0.04; C, 0.50 ± 0.12; D, 0.56 ± 0.07; E, 0.68 ± 0.05 (A vs. B p < 0.01; B vs. C,D,E p < 0.05 or p < 0.01), with a graded effect of oxygen dose in C, D and E. Pathological changes: (1) Myocardium - Mitochondrial swelling and autolysis with blurred or broken cristae was observed in the myocardium of H2S-exposed group; in group E, mitochondrial structure was basically normal, and clear cristae were found. (2) Lung tissue - In H2S-exposed group, alveolar epithelial cells disappeared, vacuolization of the organelle occurred, nuclear membrane was irregular and marginal condensation of heterochromatin was present; nucleus showed relatively normal morphology in group E, although some vacuoles still persisted within them. HBO therapy can effectively improve arterial oxygen partial pressure, and significantly reduce myocardial damage, as well as potentially relieve lung injury in this model. Further work in humans appears warranted.

Fluid inclusion volatile analysis by gas chromatography with photoionization micro-thermal conductivity detectors: Applications to magmatic MoS 2 and other H 2O-CO 2 and H 2O-CH 4 fluids

NASA Astrophysics Data System (ADS)

Bray, C. J.; Spooner, E. T. C.

1992-01-01

Eighteen fluid inclusion volatile peaks have been detected and identified from 1-2 g samples (quartz) by gas chromatography using heated (~105°C) on-line crushing, helium carrier gas, a single porous polymer column (HayeSep R; 10' × 1/8″: 100/120#; Ni alloy tubing), two temperature programme conditions for separate sample aliquots, micro-thermal conductivity (TCD) and photoionization detectors (PID; 11.7 eV lamp), and off-line digital peak processing. In order of retention time these volatile peaks are: N 2, Ar, CO, CH 4, CO 2, C 2H 4, C 2H 6, C 2H 2, COS, C 3H 6, C 3H 8, C 3H 4 (propyne), H 2O (22.7 min at 80°C), SO 2, ± iso- C4H10 ± C4H8 (1-butene) ± CH3SH, C 4H 8 (iso-butylene), (?) C 4H 6 (1,3 butadiene) and ± n- C4H10 ± C4H8 (trans-2-butene) (80 and -70°C temperature programme conditions combined). H 2O is analysed directly. O 2 can be analysed cryogenically between N 2 and Ar, but has not been detected in natural samples to date in this study. H 2S, SO 2, NH 3, HCl, HCN, and H 2 ca nnot be analysed at present. Blanks determined by crushing heat-treated Brazilian quartz (800-900°C/4 h) are zero for 80°C temperature programme conditions, except for a large, unidentified peak at ~64 min, but contain H 2O, CO 2, and some low molecular weight hydrocarbons at -70°C temperature conditions due to cryogenic accumulation from the carrier gas and subsequent elution. TCD detection limits are ~30 ppm molar in inclusions; PID detection limits are ~ 1 ppm molar in inclusions and lower for unsaturated hydrocarbons (e.g., ~0.2 ppm for C 2H 4; ~ 1 ppb for C 2H 2; ~0.3 ppb for C 3H 6). Precisions (1σ) are ~ ±1-2% and ~ ± 13% for H 2O in terms of total moles detected; the latter value is equivalent to ±0.6 mol% at the 95 mol% H 2O level. Major fluid inclusion volatile species have been successfully analysed on a ~50 mg fluid inclusion section chip (~7 mm × ~10 mm × ~100 μm). Initial inclusion volatile analyses of fluids of interpreted magmatic origin from the Cretaceous Boss Mtn. monzogranite stock-related MoS 2 deposit, central British Columbia of ~97 mol% H 2O, ~3% CO 2, ~ 140-150 ppm N 2, and ~16-39 ppm CH 4 (~300-350°C) are reasonable in comparison with high temperature (~400-900°C) volcanic gas analyses from four, active calc-alkaline volcanoes; e.g., the H 2O contents of volcanic gases from the White Island (New Zealand), Mount St. Helens (Washington, USA), Merapi (Bali, Indonesia), and Momotombo (Nicaragua) volcanoes are 88-95%, >90% (often >95%), 88-95% and ~93%, respectively; CO 2 contents are ~3-10%, 1-10%, 3-8%, and ~3.5%. CO 2/N 2 ratios for the Boss Mtn. MoS 2 fluids of ~ 190-220 are in the range for known volcanic gas ratios (e.g., ~ 150- 240; White Island). The ∑S content of the Boss Mtn. MoS 2 fluid prior to S loss by sulphide precipitation may have been ~2 mol% since CO 2/∑S molar ratios of analysed high-temperature volcanic gases are ~ 1.5. This estimate is supported by ∑S contents for White Island, Merapi and Momotombo volcanic gases of ~2%, ~0.5-2.5%, and ~2%. COS has been determined in H 2O-CO 2 fluid inclusions of interpreted magmatic origin from the Boss Mtn. MoS 2 deposit and the Tanco zoned granitic pegmatite, S.E. Manitoba at ~50-100 ppm molar levels, which are consistent with levels in volcanic gases. It appears that low, but significant, concentrations of C 2-C 4 alkanes (~ 1-20 ppm), C 2-C 4 alkenes (~ 1-480 ppb) and alkynes (e.g., C 3H 4) have been detected in magmatically derived fluids (Boss Mtn. MoS 2 deposit; Tanco granitic pegmatite). Significantly higher, low molecular weight hydrocarbon concentrations have been determined in a CH 4-rich (~ 2%), externally derived fluid of possible metamorphic or deep crustal origin trapped as inclusions in metasomatic wall-rock tourmaline adjacent to the Tanco pegmatite (e.g., 300/470 ppm C 2H 6; 50/90 ppm C 3H 8; 3-60 ppm C 2H 4/C 3H 6 n-C 4H 10).

21st Century Military Nutrition: Considerations and Approaches

DTIC Science & Technology

2008-07-15

S U H S , B e t h e s d a , M d 1 5 - 1 6 J u l 0 8 Nutrient Factors  Macronutrients  Micronutrients  Bioactive Components Non-Nutrient...Factors  Food associated  Individual associated  Environmental Nutritional Value Food Preferences & Consumption Dietary Quality Meiselman & MacFie...influences  Expectations* (marketing, education influence)  Attitudes (neophobia, involvement, dietary restraint)  Commensality (non-obese vs. obese

Towards a Comprehensive Approach to the Analysis of Categorical Data.

DTIC Science & Technology

1983-06-01

have made methodological contributions to the topic include R.L. Anderson, K. Hinkelman, 0. Kempthorne, and K. Koehler . The next section of this paper...their sufficient statistics that originated in the 1930’s with Fisher (e.g. see Dempster, 1971, and the discussion in Andersen. 1980 ). From the...ones from the original density for which h, h, .... h are MSS’s, and h ,h. h are the corresponding MSS’s in the conditional density (see Andersen, 1980

Very Large-Scale Multiuser Detection (VLSMUD)

DTIC Science & Technology

2006-09-01

networks: A market -based approach,” IEEE/ACM Transactions on Networking, vol. 13, no. 6, pp. 1325– 1338, December 2005. [5] F. Meshkati, H. V. Poor, S . C... s / / s / DAVID HENCH WARREN H. DEBANY, Jr. Work Unit Manager Technical Advisor, Information Grid Division...5e. TASK NUMBER UD 6. AUTHOR( S ) H. Vincent Poor 5f. WORK UNIT NUMBER 01 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) Princeton

Laboratory testing of the (Japan Storage Battery) traction batteries GS E75A and GS E150H

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This report describes the testing of the GS E75A and GS E150H flooded lead-acid 12-volt traction batteries and compares the selected batteries to U.S.-made electric vehicle batteries. The results and conclusions of the testing are presented.

3. Historic American Buildings Survey E. H. Pickering, Photographer October ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Historic American Buildings Survey E. H. Pickering, Photographer October 1936 ESTATE OF LORD BALTIMORE'S BROTHER-IN-LAW STONE BARN - Linden, Belair Road (U.S. Route 1), Baltimore, Independent City, MD

Correlating Temporal Rules to Time-Series Data With Rule-Based Intuition

DTIC Science & Technology

2010-03-01

t i m e o b j e c t and r e t u r n s True ( i n r u l e ) or F a l s e ( n o t i n r u l e ) . Des ign : r u l e l i s t − an a r r a y t h...e . d a t e o b j e c t s . ””” def i n i t ( s e l f , name , days , i g n o r e y e a r =True ) : s e l f . name = name s e l f . days = days 49 s...a l . tm wday == 6 r u l e l i s t . append ( Sunday ( ) ) c l a s s J a n u a r y ( TimeRule ) : ””” I s True i f i t i s January

Evaluating the Effectiveness of Air Force Foundational Cyberspace Training

DTIC Science & Technology

2012-06-14

fileticket=zAcDCP6H2T4%3d&tabid=56&mid=415 (accessed 25 May 2012). VIT .1 Vita . U N I T E D S T A T E S A I R F O R C E MAJOR APRIL...as of May 2012) VIT .2 . U N I T E D S T A T E S A I R F O R C E MAJOR APRIL L. WIMMER ASSIGNMENTS 1. September 2000

VHE gamma-ray Emitting Pulsar Wind Nebulae Discovered by H.E.S.S.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gallant, Y.A.; /Montpellier U.; Carrigan, S.

2008-06-05

Recent advances in very-high-energy (VHE) gamma-ray astronomy have opened a new observational window on the physics of pulsars. The high sensitivity of current imaging atmospheric Cherenkov telescopes, and in particular of the H.E.S.S. array, has already led to the discovery of about a dozen VHE-emitting pulsar wind nebulae (PWNe) and PWN candidates. These include the plerions in the composite supernova remnants MSH 15-52, G21.5-0.9, Kes 75, and Vela, two sources in the Kookaburra, and the nebula of PSR B1823-13. This VHE emission is generally interpreted as inverse Compton emission from the relativistic electrons and positrons accelerated by the pulsar andmore » its wind; as such, it can yield a more direct spatial and spectral view of the accelerated particles than can be inferred from observations of their synchrotron emission. The VHE-emitting PWNe detected by the H.E.S.S. telescopes are reviewed and the implications for pulsar physics discussed.« less

Coagulopathy and Shock on Admission is Associated with Mortality for Children with Traumatic Injuries at Combat Support Hospitals

DTIC Science & Technology

2012-01-01

Charles E . Wade, PhD; Lorne H. Blackbourne, MD; Philip C. Spinella, MD Trauma remains one of the most common causes of death in all age groups...the U.S. Government. The authors have not disclosed any potential conflicts of interest. For information regarding this article, E -mail: Jpatregnani...ELEMENT NUMBER 6. AUTHOR(S) Patregnani J. T., Borgman M. A., Maegele M., Wade C. E ., Blackbourne L. H., Spinella P. C., 5d. PROJECT NUMBER 5e. TASK

Prime Contract Awards by State or Country, Place and Contractor. Part 1 (Addison, Alabama - Mountain Pine, Arkansas), FY1991

DTIC Science & Technology

1991-01-01

460oo4OOoo S03 : I (oo E a -T E4 *4 4 to- r-4 inIn canan a .-40000 .40000 00 000000 00 M0 0 1 (0(0 a 0-4 0-4 *-4 -- 4 0-1-4 .4-4..4 -1 .--- 4.4 L-4-4 -1 -4...z ZZZZ ZZ 2 Z 2 z IL 0 -0 H o CO a z zzzzz z z z z z z z z z I ivan HO1 0 40 0 0 0 0 0. o 0o H I 0-*w H ’ H ) 0-*< H3 a S c 04 0 H u00 H~ 0 QSNN NNN

[Comparative study of sleep patterns in nurses working day and night shifts].

PubMed

De Martino, Milva Maria Figueiredo

2002-08-01

To compare sleep patterns in nurses working day and night shifts in a hospital in Campinas (SP), Brazil. Fifty-nine nurses between 23 and 59 years of age participated in the study. For day shift workers, the pattern of nocturnal sleep was examined; for night shift workers, nocturnal and diurnal sleep patterns were examined. During 1 week, participants filled out a sleep diary right after waking up. The following items were assessed: time going to bed, falling asleep, and waking up; sleep latency; duration in hours of nocturnal and diurnal sleep; naps; quality of sleep; mode of waking up; and comparison between the sleep recorded in the diary with the usual sleep. Personal and professional information was also collected. Day shift workers went to bed at 23h36min, and night workers at 23h52min (P > 0.05). The nurses working a day schedule woke up earlier (7h3min) than those working a night schedule when they slept at night (8h30min) (P

Mexico: Its Economic, Political and Social Situation and Its Implications for the United States

DTIC Science & Technology

1991-04-25

visible factors are hauling and pulling in different directions. The oil trade is itself being affected by a nurber of powerful factors, Whet.he- or not Me...oppori tuni1 t 1ies t,- r fad e i ts na.t i .: -a I p,- .:. i c t. mocre v iabl 1e. I t i s w it h t h Is goalI in mi 111nd t.h at ei CoC i s r ea dy

Hydrogen Sulfide Mitigates Reperfusion Injury in a Porcine Model of Vascularized Composite Autotransplantation

DTIC Science & Technology

2014-05-01

H2S in tissue preservation and stabilization. Blackstone et al12 demonstrated the ability of H2S to induce a state of suspended ani- mation in mice by...Williams & Wilkins. Unauthorized reproduction of this article is prohibited. 12. Blackstone E, Morrison M, Roth M. H2S induces a suspended animation

Editorial: Focus on X-ray Beams with High Coherence

NASA Astrophysics Data System (ADS)

Robinson, Ian; Gruebel, Gerhard; Mochrie, Simon

2010-03-01

This editorial serves as the preface to a special issue of New Journal of Physics, which collects together solicited papers on a common subject, x-ray beams with high coherence. We summarize the issue's content, and explain why there is so much current interest both in the sources themselves and in the applications to the study of the structure of matter and its fluctuations (both spontaneous and driven). As this collection demonstrates, the field brings together accelerator physics in the design of new sources, particle physics in the design of detectors, and chemical and materials scientists who make use of the coherent beams produced. Focus on X-ray Beams with High Coherence Contents Femtosecond pulse x-ray imaging with a large field of view B Pfau, C M Günther, S Schaffert, R Mitzner, B Siemer, S Roling, H Zacharias, O Kutz, I Rudolph, R Treusch and S Eisebitt The FERMI@Elettra free-electron-laser source for coherent x-ray physics: photon properties, beam transport system and applications E Allaria, C Callegari, D Cocco, W M Fawley, M Kiskinova, C Masciovecchio and F Parmigiani Beyond simple exponential correlation functions and equilibrium dynamics in x-ray photon correlation spectroscopy Anders Madsen, Robert L Leheny, Hongyu Guo, Michael Sprung and Orsolya Czakkel The Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source (LCLS) Sébastien Boutet and Garth J Williams Dynamics and rheology under continuous shear flow studied by x-ray photon correlation spectroscopy Andrei Fluerasu, Pawel Kwasniewski, Chiara Caronna, Fanny Destremaut, Jean-Baptiste Salmon and Anders Madsen Exploration of crystal strains using coherent x-ray diffraction Wonsuk Cha, Sanghoon Song, Nak Cheon Jeong, Ross Harder, Kyung Byung Yoon, Ian K Robinson and Hyunjung Kim Coherence properties of the European XFEL G Geloni, E Saldin, L Samoylova, E Schneidmiller, H Sinn, Th Tschentscher and M Yurkov Fresnel coherent diffractive imaging: treatment and analysis of data G J Williams, H M Quiney, A G Peele and K A Nugent Imaging of complex density in silver nanocubes by coherent x-ray diffraction R Harder, M Liang, Y Sun, Y Xia and I K Robinson Methodology for studying strain inhomogeneities in polycrystalline thin films during in situ thermal loading using coherent x-ray diffraction N Vaxelaire, H Proudhon, S Labat, C Kirchlechner, J Keckes, V Jacques, S Ravy, S Forest and O Thomas Ptychographic coherent diffractive imaging of weakly scattering specimens Martin Dierolf, Pierre Thibault, Andreas Menzel, Cameron M Kewish, Konstantins Jefimovs, Ilme Schlichting, Konstanze von König, Oliver Bunk and Franz Pfeiffer Dose requirements for resolving a given feature in an object by coherent x-ray diffraction imaging Andreas Schropp and Christian G Schroer FLASH: new opportunities for (time-resolved) coherent imaging of nanostructures R Treusch and J Feldhaus Structure of a single particle from scattering by many particles randomly oriented about an axis: toward structure solution without crystallization? D K Saldin, V L Shneerson, M R Howells, S Marchesini, H N Chapman, M Bogan, D Shapiro, R A Kirian, U Weierstall, K E Schmidt and J C H Spence Analysis of strain and stacking faults in single nanowires using Bragg coherent diffraction imaging V Favre-Nicolin, F Mastropietro, J Eymery, D Camacho, Y M Niquet, B M Borg, M E Messing, L-E Wernersson, R E Algra, E P A M Bakkers, T H Metzger, R Harder and I K Robinson Coherent science at the SwissFEL x-ray laser B D Patterson, R Abela, H-H Braun, U Flechsig, R Ganter, Y Kim, E Kirk, A Oppelt, M Pedrozzi, S Reiche, L Rivkin, Th Schmidt, B Schmitt, V N Strocov, S Tsujino and A F Wrulich Energy recovery linac (ERL) coherent hard x-ray sources Donald H Bilderback, Joel D Brock, Darren S Dale, Kenneth D Finkelstein, Mark A Pfeifer and Sol M Gruner Statistical and coherence properties of radiation from x-ray free-electron lasers E L Saldin, E A Schneidmiller and M V Yurkov Microscopic return point memory in Co/Pd multilayer films K A Seu, R Su, S Roy, D Parks, E Shipton, E E Fullerton and S D Kevan Holographic and diffractive x-ray imaging using waveguides as quasi-point sources K Giewekemeyer, H Neubauer, S Kalbfleisch, S P Krüger and T Salditt Mapping the conformations of biological assemblies P Schwander, R Fung, G N Phillips Jr and A Ourmazd Imaging the displacement field within epitaxial nanostructures by coherent diffraction: a feasibility study Ana Diaz, Virginie Chamard, Cristian Mocuta, Rogerio Magalhães-Paniago, Julian Stangl, Dina Carbone, Till H Metzger and Günther Bauer The potential for two-dimensional crystallography of membrane proteins at future x-ray free-electron laser sources Cameron M Kewish, Pierre Thibault, Oliver Bunk and Franz Pfeiffer Coherence properties of hard x-ray synchrotron sources and x-ray free-electron lasers I A Vartanyants and A Singer Coherent imaging of biological samples with femtosecond pulses at the free-electron laser FLASH A P Mancuso, Th Gorniak, F Staier, O M Yefanov, R Barth, C Christophis, B Reime, J Gulden, A Singer, M E Pettit, Th Nisius, Th Wilhein, C Gutt, G Grübel, N Guerassimova, R Treusch, J Feldhaus, S Eisebitt, E Weckert, M Grunze, A Rosenhahn and I A Vartanyants

31 CFR 315.35 - Payment (redemption).

Code of Federal Regulations, 2013 CFR

2013-07-01

... and Savings Notes. A Series E bond will be paid at any time after two months from issue date at the... interest is $6.90 per $500. (e) Series H. A Series H bond will be redeemed at face value at any time after..., SERIES A, B, C, D, E, F, G, H, J, AND K, AND U.S. SAVINGS NOTES General Provisions for Payment § 315.35...

31 CFR 315.35 - Payment (redemption).

Code of Federal Regulations, 2010 CFR

2010-07-01

... and Savings Notes. A Series E bond will be paid at any time after two months from issue date at the... interest is $6.90 per $500. (e) Series H. A Series H bond will be redeemed at face value at any time after..., SERIES A, B, C, D, E, F, G, H, J, AND K, AND U.S. SAVINGS NOTES General Provisions for Payment § 315.35...

31 CFR 315.35 - Payment (redemption).

Code of Federal Regulations, 2012 CFR

2012-07-01

... and Savings Notes. A Series E bond will be paid at any time after two months from issue date at the... interest is $6.90 per $500. (e) Series H. A Series H bond will be redeemed at face value at any time after..., SERIES A, B, C, D, E, F, G, H, J, AND K, AND U.S. SAVINGS NOTES General Provisions for Payment § 315.35...

31 CFR 315.35 - Payment (redemption).

Code of Federal Regulations, 2011 CFR

2011-07-01

... and Savings Notes. A Series E bond will be paid at any time after two months from issue date at the... interest is $6.90 per $500. (e) Series H. A Series H bond will be redeemed at face value at any time after..., SERIES A, B, C, D, E, F, G, H, J, AND K, AND U.S. SAVINGS NOTES General Provisions for Payment § 315.35...

Variable (Tg, Ts) Measurements of Alkane Dissociative Sticking Coefficients

NASA Astrophysics Data System (ADS)

Valadez, Leticia; Dewitt, Kristy; Abbott, Heather; Kolasinski, Kurt; Harrision, Ian

2006-03-01

Dissociative sticking coefficients S(Tg, Ts) for CH4 and C2H6 on Pt(111) have been measured as a function of gas temperature (Tg) and surface temperature (Ts) using an effusive molecular beam. Microcanonical unimolecular rate theory (MURT) was employed to extract transition state characteristics [e.g., E0(CH4) = 52.5±3.5 kJ/mol-1 and E0(C2H6) = 26.5±3 kJ/mol-1]. MURT allows our S(Tg, Ts) values to be directly compared to other supersonic molecular beam and thermal equilibrium sticking measurements. The S(Tg, Ts) depend strongly on Ts, however, only for CH4 is a strong Tg dependence observed. The fairly weak Tg dependence for C2H6 suggests that vibrational mode specific behavior and/or molecular rotations play stronger roles in the dissociative chemisorption of C2H6 than they do for CH4. Interestingly, thermal S(Tg=Ts) predictions based on MURT modeling of our CH4/Pt(111) data are three orders of magnitude higher than recent thermal equilibrium measurements on supported Pt nanocrystallite catalysts [J. M. Wei, E. Iglesia, J. Phys. Chem. B 108, 4094 (2004)].

Antibacterial Activities of Wasabi against Escherichia coli O157:H7 and Staphylococcus aureus

PubMed Central

Lu, Zhongjing; Dockery, Christopher R.; Crosby, Michael; Chavarria, Katherine; Patterson, Brett; Giedd, Matthew

2016-01-01

Escherichia coli O157:H7 and Staphylococcus aureus are two of the major pathogens frequently involved in foodborne outbreaks. Control of these pathogens in foods is essential to food safety. It is of great interest in the use of natural antimicrobial compounds present in edible plants to control foodborne pathogens as consumers prefer more natural “green” foods. Allyl isothiocyanate (AITC) is an antimicrobial compound naturally present in wasabi (Japanese horseradish) and several other edible plants. Although the antibacterial effects of pure AITC and wasabi extract (essential oil) against several bacteria have been reported, the antibacterial property of natural wasabi has not been well studied. This study investigated the antibacterial activities of wasabi as well as AITC against E. coli O157:H7 and S. aureus. Chemical analysis showed that AITC is the major isothiocyanate in wasabi. The AITC concentration in the wasabi powder used in this study was 5.91 ± 0.59 mg/g. The minimum inhibitory concentration (MIC) of wasabi against E. coli O157:H7 or S. aureus was 1% (or 10 mg/ml). Wasabi at 4% displayed higher bactericidal activity against S. aureus than against E. coli O157:H7. The MIC of AITC against either pathogen was between 10 and 100 μg/ml. AITC at 500 μg/ml was bactericidal against both pathogens while AITC at 1000 μg/ml eliminated E. coli O157:H7 much faster than S. aureus. The results from this study showed that wasabi has strong antibacterial property and has high potential to effectively control E. coli O157:H7 and S. aureus in foods. The antibacterial property along with its natural green color, unique flavor, and advantage to safeguard foods at the point of ingestion makes wasabi a promising natural edible antibacterial plant. The results from this study may be of significant interest to the food industry as they develop new and safe foods. These results may also stimulate more research to evaluate the antibacterial effect of wasabi against other foodborne pathogens and to explore other edible plants for their antimicrobial properties. To our knowledge, this is the first report on the antibacterial activity of wasabi in its natural form of consumption against E. coli O157:H7 and S. aureus. PMID:27708622

Antibacterial Activities of Wasabi against Escherichia coli O157:H7 and Staphylococcus aureus.

PubMed

Lu, Zhongjing; Dockery, Christopher R; Crosby, Michael; Chavarria, Katherine; Patterson, Brett; Giedd, Matthew

2016-01-01

Escherichia coli O157:H7 and Staphylococcus aureus are two of the major pathogens frequently involved in foodborne outbreaks. Control of these pathogens in foods is essential to food safety. It is of great interest in the use of natural antimicrobial compounds present in edible plants to control foodborne pathogens as consumers prefer more natural "green" foods. Allyl isothiocyanate (AITC) is an antimicrobial compound naturally present in wasabi (Japanese horseradish) and several other edible plants. Although the antibacterial effects of pure AITC and wasabi extract (essential oil) against several bacteria have been reported, the antibacterial property of natural wasabi has not been well studied. This study investigated the antibacterial activities of wasabi as well as AITC against E . coli O157:H7 and S . aureus . Chemical analysis showed that AITC is the major isothiocyanate in wasabi. The AITC concentration in the wasabi powder used in this study was 5.91 ± 0.59 mg/g. The minimum inhibitory concentration (MIC) of wasabi against E. coli O157:H7 or S. aureus was 1% (or 10 mg/ml). Wasabi at 4% displayed higher bactericidal activity against S. aureus than against E. coli O157:H7. The MIC of AITC against either pathogen was between 10 and 100 μg/ml. AITC at 500 μg/ml was bactericidal against both pathogens while AITC at 1000 μg/ml eliminated E. coli O157:H7 much faster than S. aureus . The results from this study showed that wasabi has strong antibacterial property and has high potential to effectively control E. coli O157:H7 and S. aureus in foods. The antibacterial property along with its natural green color, unique flavor, and advantage to safeguard foods at the point of ingestion makes wasabi a promising natural edible antibacterial plant. The results from this study may be of significant interest to the food industry as they develop new and safe foods. These results may also stimulate more research to evaluate the antibacterial effect of wasabi against other foodborne pathogens and to explore other edible plants for their antimicrobial properties. To our knowledge, this is the first report on the antibacterial activity of wasabi in its natural form of consumption against E. coli O157:H7 and S. aureus .

Perfection and Entry: An Example,

DTIC Science & Technology

1983-07-01

p(t),a(t)) 0 I t=fi I (2) - t-1 H ([p,a]) = (I - C) I h (p(t),a(t)) E t-1 E The stationary equilibrium outcomes of such a game are those strategy...aSO41 SuOwe seP! JO ague4:pxO a4) aMP)! 03 s! asodind Ja4aIL ye~s leuossajoid sll ol asias e se uoiejodioj) puell a4. Aq partssi ate siaded saiuaS...does not 1). reduce the set of equilibrium outcomes in the discounted gamelJ. The essential features of the market situation required to produce the phe

The Opposing Roles of Nucleophosmin and the ARF Tumor Suppressor in Breast Cancer

DTIC Science & Technology

2007-04-01

P ., R. K. Busch, B. C. Valdez, and H. Busch. 1996 . C23 interacts with B23, a putative nucleolar...beneficial anti-cancer activity of peptides in vivo. Injection of a peptide from the von Hippel -Lindau (VHL) tumor suppressor inhibited the growth and... 240 WT Arf -/- 1 2 3 4 5 0 C y to s o lic 3 H -M e th y l M e th io n in e c p m ( x 1 0 3 ) A 28S 18S WT chase (min): Arf -/- 120 240 120 240 N

Studies in Rheoencephalography (REG)

DTIC Science & Technology

2010-04-01

r o t i d F l o w m L / m i n i R E G A r b . u n i t E K G m V S A P m m H g S h e d b l o o d m l Bodo: Studies in Rheoencephalography (REG). J...Bodo M, Pearce F, Garcia A, Van Albert S, Settle T , Szebe- ni J, Baranyi L, Hartings J, Armonda R . In vivo cerebral blood flow autoregulation...Microsoft, Redmond, WA) spreadsheet for further processing unless published differently. In most cases, the Student t -test was used for statistical

Naval Postgraduate School Research. Volume 9, Number 2, June 1999

DTIC Science & Technology

1999-06-01

widths of a few tenths of a degree of R E S E A R C H N A V A L P O S T G R A D U A T E S C H O O L Report Documentation Page Form ApprovedOMB No. 0704...TASK FORCES FROM ANTI-SHIP MISSILE ATTACK LCDR James R . Townsend, USN Master of Science in Operations Research-March 1999 Advisors: Professor James G ...Command, Control and Communications Academic Group Michael G . Sovereign, Rolands and Associates LT Michelle Glenn, USN CDR Ray Holt, USN Capt Steve Paxton

A Recombinant Humanized Anti-Cocaine Monoclonal Antibody Inhibits the Distribution of Cocaine to the Brain in Rats

PubMed Central

Gooden, Felicia C. T.; Tabet, Michael R.; Ball, William J.

2014-01-01

The monoclonal antibody (mAb), h2E2, is a humanized version of the chimeric human/murine anti-cocaine mAb 2E2. The recombinant h2E2 protein was produced in vitro from a transfected mammalian cell line and retained high affinity (4 nM Kd) and specificity for cocaine over its inactive metabolites benzoylecgonine (BE) and ecgonine methyl ester. In rats, pharmacokinetic studies of h2E2 (120 mg/kg i.v.) showed a long terminal elimination half-life of 9.0 days and a low volume of distribution at steady state (Vdss) of 0.3 l/kg. Pretreatment with h2E2 produced a dramatic 8.8-fold increase in the area under the plasma cocaine concentration-time curve (AUC) and in brain a concomitant decrease of 68% of cocaine’s AUC following an i.v. injection of an equimolar cocaine dose. Sequestration of cocaine in plasma by h2E2, shown via reduction of cocaine’s Vdss, indicates potential clinical efficacy. Although the binding of cocaine to h2E2 in plasma should inhibit distribution and metabolism, the elimination of cocaine remained multicompartmental and was still rapidly eliminated from plasma despite the presence of h2E2. BE was the major cocaine metabolite, and brain BE concentrations were sixfold higher than in plasma, indicating that cocaine is normally metabolized in the brain. In the presence of h2E2, brain BE concentrations were decreased and plasma BE was increased, consistent with the observed h2E2-induced changes in cocaine disposition. The inhibition of cocaine distribution to the brain confirms the humanized mAb, h2E2, as a lead candidate for development as an immunotherapy for cocaine abuse. PMID:24733787

Relationships between IgE/IgG4 Epitopes, Structure and Function in Anisakis simplex Ani s 5, a Member of the SXP/RAL-2 Protein Family

PubMed Central

García-Mayoral, María Flor; Treviño, Miguel Angel; Pérez-Piñar, Teresa; Caballero, María Luisa; Knaute, Tobias; Umpierrez, Ana

2014-01-01

Background Anisakiasis is a re-emerging global disease caused by consumption of raw or lightly cooked fish contaminated with L3 Anisakis larvae. This zoonotic disease is characterized by severe gastrointestinal and/or allergic symptoms which may misdiagnosed as appendicitis, gastric ulcer or other food allergies. The Anisakis allergen Ani s 5 is a protein belonging to the SXP/RAL-2 family; it is detected exclusively in nematodes. Previous studies showed that SXP/RAL-2 proteins are active antigens; however, their structure and function remain unknown. The aim of this study was to elucidate the three-dimensional structure of Ani s 5 and its main IgE and IgG4 binding regions. Methodology/Principal Findings The tertiary structure of recombinant Ani s 5 in solution was solved by nuclear magnetic resonance. Mg2+, but not Ca2+, binding was determined by band shift using SDS-PAGE. IgE and IgG4 epitopes were elucidated by microarray immunoassay and SPOTs membranes using sera from nine Anisakis allergic patients. The tertiary structure of Ani s 5 is composed of six alpha helices (H), with a Calmodulin like fold. H3 is a long, central helix that organizes the structure, with H1 and H2 packing at its N-terminus and H4 and H5 packing at its C-terminus. The orientation of H6 is undefined. Regarding epitopes recognized by IgE and IgG4 immunoglobulins, the same eleven peptides derived from Ani s 5 were bound by both IgE and IgG4. Peptides 14 (L40-K59), 26 (A76-A95) and 35 (I103-D122) were recognized by three out of nine sera. Conclusions/Significance This is the first reported 3D structure of an Anisakis allergen. Magnesium ion binding and structural resemblance to Calmodulin, suggest some putative functions for SXP/RAL-2 proteins. Furthermore, the IgE/IgG4 binding regions of Ani s 5 were identified as segments localized on its surface. These data will contribute towards a better understanding of the interactions that occur between immunoglobulins and allergens and, in turn, facilitate the design of novel diagnostic tests and immunotherapeutic strategies. PMID:24603892

29 CFR 776.19 - Employees of independent employers meeting needs of producers for commerce.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Electrical Co. v. Walling, 326 U.S. 657; Farmers Reservoir Co. v. McComb, 337 U.S. 755; H. Mgrs. St., 1949, p... U.S. 578. 97 H. Mgrs. St., 1949, p. 14; Kirschbaum Co. v. Walling, 316 U.S. 517; Warren-Bradshaw Drilling Co. v. Hall, 317 U.S. 88. 98 See H. Mgrs. St., p. 14, and 10 E. 40th St. Bldg. Co. v. Callus, 325...

Real-Time Radio Wave Propagation for Mobile Ad-Hoc Network Emulation and Simulation Using General Purpose Graphics Processing Units (GPGPUs)

DTIC Science & Technology

2014-05-01

COST-Walfisch- Ikegami model (14) estimates the received power predominantly on the basis of frequency and distance to the transmitter. Ray-optical (15...34 # $ $ # % & ’ ( ) * + , , - . / - 0 1 2 3 4 5 6 7 7 6 8 9 : ; < = > ? @ A B C ? D E F A B G H ? E E I J K L M N O P Q R S T U V W X S Y Z O Y [ Q [ \\ W O P...a b _ c _ d _ e f ` d g h ` i j k l l m n o p k q r s t u v w w x y z

Assessment of biofilm changes and concentration-depth profiles during arsenopyrite oxidation by Acidithiobacillus thiooxidans.

PubMed

Ramírez-Aldaba, Hugo; Vazquez-Arenas, Jorge; Sosa-Rodríguez, Fabiola S; Valdez-Pérez, Donato; Ruiz-Baca, Estela; García-Meza, Jessica Viridiana; Trejo-Córdova, Gabriel; Lara, René H

2017-08-01

Biofilm formation and evolution are key factors to consider to better understand the kinetics of arsenopyrite biooxidation. Chemical and surface analyses were carried out using Raman spectroscopy, scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), glow discharge spectroscopy (GDS), and protein analysis (i.e., quantification) in order to evaluate the formation of intermediate secondary compounds and any significant changes arising in the biofilm structure of Acidithiobacillus thiooxidans during a 120-h period of biooxidation. Results show that the biofilm first evolves from a low cell density structure (1 to 12 h) into a formation of microcolonies (24 to 120 h) and then finally becomes enclosed by a secondary compound matrix that includes pyrite (FeS 2 )-like, S n 2- /S 0 , and As 2 S 3 compounds, as shown by Raman and SEM-EDS. GDS analyses (concentration-depth profiles, i.e., 12 h) indicate significant differences for depth speciation between abiotic control and biooxidized surfaces, thus providing a quantitative assessment of surface-bulk changes across samples (i.e. reactivity and /or structure-activity relationship). Respectively, quantitative protein analyses and CLSM analyses suggest variations in the type of extracellular protein expressed and changes in the biofilm structure from hydrophilic (i.e., exopolysaccharides) to hydrophobic (i.e., lipids) due to arsenopyrite and cell interactions during the 120-h period of biooxidation. We suggest feasible environmental and industrial implications for arsenopyrite biooxidation based on the findings of this study.

Genetically Programming Interfaces between Active Materials, Conductive Pathway and Current Collector in Li Ion Batteries

DTIC Science & Technology

2012-01-01

2 Recombinant M13 phages Clone ID pIII pVIII E4-A1 STIHGST EEEE E4-A2 ATFNTMT EEEE E4-S7 SSSSSSS EEEE E4- T7 TTTTTTT EEEE E4-H7 HHHHHHH EEEE...higher binding strength, with A1 and H7 motifs 0 5E+10 1E+11 1.5E+11 2E+11 E4-W E4-A1 E4- T7 E4-H7 Phage Clones ECS Transactions, 41 (41) 55-64...prepared through conventional approaches. 5 Compared to other bio-templates used, the advantages of M13 phages exist not only in their well-understood

Performance Characterization of the Free Molecule Micro-Resistojet Utilizing Water Propellant (Postprint)

DTIC Science & Technology

2007-07-01

Micci and A. Ketsdever, AIAA Progress in Astronautics and Aeronautics, Vol 187, pp. 45-137, 2000. 3. Janson, S., Helvajian , H ., Hansen, W., and...the radius of the propellant tank. The volume of the empty portion of a spherical propellant tank is given by ( )2 21 33e e t eV h r hπ= + (1...Where the resulting height of the propellant is 2p t eh r h = − (2) A correlation between p t h r and w m M is found in ref. 10. For the

Performance Characterization of the Free Molecule Micro-Resistojet Utilizing Water Propellant (Preprint)

DTIC Science & Technology

2007-05-24

187, pp. 45-137, 2000. 3. Janson, S., Helvajian , H ., Hansen, W., and Lodmell, J. “Microthrusters for Nanosatellites,” The Second International...spherical propellant tank is given by ( )2 21 33e e t eV h r hπ= + (1) Where the resulting height of the propellant is 2p t eh r h = − (2) A...correlation between p t h r and w m M is found in ref. 10. For the parameters of the TD, the resulting mass of the sloshing waves prior to the burn

Noise Levels and Flight Profiles of Eight Helicopters Using Proposed International Certification Procedures

DTIC Science & Technology

1979-03-01

it.~ It En U-1 fx~ I o z.~ ~ ~60 -l .00 0J 0.4 >, 4 1 JI II r-E.4 In t I蘉[ NIrolff:f~ 61 . U, *0 E44 oo Ln t4 0 co~ S la,) a’H Lat rDH3A 462 03...the Bell 212 (H-1) and the Sikorsky S- 61 (H-3) Purolator, Inc. Provided the Gazelle Ronson Aviation, Trenton, New Jersey ti Iii TABLE OF CONTE ’TS...Photograph: S- 61 (H-3) 22 2.3.6 Photograph: Bell 212 (UHIN) 23 2.3.7 Photograph: Hughes 500C 24 2.3.8 Photograph: SA 341G 25 4.2.1 NAFEG’ lest Data

Deep H.E.S.S. observations of the supernova remnant RX J0852.0-4622

NASA Astrophysics Data System (ADS)

Sushch, Iurii; Paz Arribas, Manuel; Komin, Nukri; Schwanke, Ullrich

2016-06-01

The largest TeV source, RX J0852.0-4622 (Vela Jr.), is one of the few supernova remnants (SNRs) with well resolved shell-like morphology at very-high-energy (VHE; E>100 GeV) gamma-rays. Strong non-thermal emission across the electromagnetic spectrum from radio to VHE gamma-rays, young age and proximity of the remnant makes it one of the prime objects for the study of particle acceleration aiming to test the paradigm of SNRs being sources of Galactic cosmic rays. Here we present deep H.E.S.S. observations of RX J0852.0-4622 with roughly doubled exposure comparing to previously published results. Improved statistics together with new analysis techniques result in a firm determination of the cut-off in the gamma-ray spectrum and allow the spatially resolved spectroscopy studies. A smooth connection of the H.E.S.S. spectrum to the spectrum at GeV energies as reported by Fermi/LAT provides an exciting opportunity to recover the present-time parent particle population in both leptonic and hadronic scenarios directly from the gamma-ray data alone. These new observations provide us a deeper insight and better understanding of the physical processes in SNRs.

Shaping the Security Environment Newport paper no. 29

DTIC Science & Technology

2006-11-29

interest in and set the stage for a ministerial conference. That ministerial conference, held in November 2006 in Cotonou , Benin, brought together...awareness has been at least partially met. The Accra workshop and Cotonou Ministerial Conference were both considered suc- cessful in that the outputs...Organization and the Maritime Organization for West and Central Africa in the Accra workshop and Cotonou S H A P I N G T H E S E C U R I T Y E N V I R

RTO Meeting Proceedings 16, Aircraft Weapon System Compatibility and Integration held in Chester, United Kingdom, 28-30 September, 1998

DTIC Science & Technology

1999-04-01

project, there was a requirement to place a camera behind a each photogrammetric target in the image and for each cylindrically curved window...testing. T by the wind tunnel’s captive trajectory sting, U.S. wing open effets on the o erthnd, h e Navyengneer h e obervd sgnifcan difereces wing...Flying Qualities, Symposium on Aeroballistics, May 1981. Aerodynamics, and Structures disciplines benefit directly 6. Magnus , A. E., and Epton, M. A

Integrating Training Simulations and e-Learning Systems: The SimSCORM Platform (Integratie van Training Simulaties en e-Learning Systemen: Het SimSCORM Platform)

DTIC Science & Technology

2008-07-01

SimSCORM Opdrachtnummer Trainingsconcepten voor Defensie Datum Programmanummer Projectnummer juli 2008 V406 032.13224 Auteur (s) ir H.L.H. de Penning...simulators can provide learners with powerful and realistic learning environments: whereas e-learning systems provide them with interactive, mostly theory ...practice and theory , in both learning and evaluation, is becoming increasingly important. From a learner’s point of view, a powerful learning environment

Electrical percolation threshold of magnetostrictive inclusions in a piezoelectric matrix under simulated sintering conditions

NASA Astrophysics Data System (ADS)

Bedard, Antoine Joseph; Barbero, Ever J.

2018-03-01

Magnetoelectric (ME) composites can be produced by embedding magnetostrictive H particles in a piezoelectric E matrix derived from a piezoelectric powder precursor. Previously, using a bi-disperse hard-shell model (Barbero and Bedard in Comput Part Mech, 2018. https://doi.org/10.1007/s40571-017-0165-4), it has been shown that the electrical percolation threshold of the conductive H phase can be increased by decreasing the piezoelectric E particle size, relative to the H phase particle size, and by increasing short-range affinity between the E and H particles. This study builds on our previous study by exploring what happens during sintering of the ME composite when either the H or E particles undergo deformation. It was found that deformation of the H particles reduces the percolation threshold, and that deformation of E particles increases inter-phase H-E mechanical coupling, thus contributing to enhancing of ME coupling.

Uso de curativo a vácuo como terapia adjuvante na cicatrização de sítio cirúrgico infectado

PubMed Central

de Camargo, Paula Angeleli Bueno; Bertanha, Matheus; Moura, Regina; Jaldin, Rodrigo Gibin; Yoshida, Ricardo de Alvarenga; Pimenta, Rafael Elias Farres; Mariúba, Jamil Victor de Oliveira; Sobreira, Marcone Lima

2016-01-01

Resumo Infecções de sítios cirúrgicos com envolvimento de próteses sintéticas constituem grande desafio para tratamento. Apresentamos o caso de uma paciente com múltiplas comorbidades, histórico de enxerto aortobifemoral há 6 anos e reabordagem das anastomoses femorais por reestenoses há 5 anos. Apresentou dor inguinal esquerda e abaulamento súbitos com diagnóstico de pseudoaneurisma femoral roto e instabilidade hemodinâmica. Foi submetida a correção emergencial com interposição de prótese de dácron recoberta por prata e correção de grande hérnia incisional abdominal com tela sintética ao mesmo tempo. No pós-operatório, manteve-se por longo período sob terapia intensiva com dificuldade de extubação. Nesse ínterim, apresentou deiscência das suturas e fístula purulenta inguinal esquerda em contato com a prótese vascular. Optou-se pelo tratamento conservador, com desbridamento das feridas e aplicação de curativo a vácuo. A paciente evoluiu com melhora e cicatrização das feridas. Essa pode se constituir em ferramenta importante em casos similares.

Accurate Dynamic Response Predictions of Plug-and-Play Sat I

DTIC Science & Technology

2010-03-01

damping. The foam pads are necessary to damp out the s ystem b etween s trikes f rom t he s haker . Elevating t he f oam p ads p rovides i ncreased... haker set to a ct as an au tomatic p ing h ammer ( Figure 15) provides impulse like excitiations. A Hewlett Packard 33120A 15MHz/Arbitray...n M B Dynamics C al50 E xciter el ectrodynamic s haker b eing d riven b y a H ewlett P ackard 33120A 15M Hz/Arbitrary waveform generator p

Exact expression of the t-J model in terms of local spin and fermionic holon operators

NASA Astrophysics Data System (ADS)

Wang, Y. R.; Rice, M. J.

1994-02-01

An exact expression for the Hamiltonian H of the t-J model in terms of local spin (Si) and fermionic holon (ei) operators is derived which requires no constraint between these operators. The result for the Hamiltonian H is H=-t tsumijeie°j(1/2+2Si.Sj)+(J/2)t smij(1-e°iei)(Si.Sj-1/4)(1-e°je The number of electrons at site i is given by ni=1-e°iei, and the true spin operator S~i, is related to the local spin operator by S~i=(1-e°iei)Si. The expression correctly produces the Nagaoka theorem in the limit J-->0, and preserves the time-reversal symmetry of the original model. For a bipartite lattice, H describes a competition between ferromagnetism, favored by the hopping term, and antiferromagnetism, favored by the Heisenberg term.

Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats.

PubMed

Tan, Gang; Pan, Shangha; Li, Jie; Dong, Xuesong; Kang, Kai; Zhao, Mingyan; Jiang, Xian; Kanwar, Jagat R; Qiao, Haiquan; Jiang, Hongchi; Sun, Xueying

2011-01-01

Hydrogen sulfide (H(2)S) displays vasodilative, anti-oxidative, anti-inflammatory and cytoprotective activities. Impaired production of H(2)S contributes to the increased intrahepatic resistance in cirrhotic livers. The study aimed to investigate the roles of H(2)S in carbon tetrachloride (CCl(4))-induced hepatotoxicity, cirrhosis and portal hypertension. Sodium hydrosulfide (NaHS), a donor of H(2)S, and DL-propargylglycine (PAG), an irreversible inhibitor of cystathionine γ-lyase (CSE), were applied to the rats to investigate the effects of H(2)S on CCl(4)-induced acute hepatotoxicity, cirrhosis and portal hypertension by measuring serum levels of H(2)S, hepatic H(2)S producing activity and CSE expression, liver function, activity of cytochrome P450 (CYP) 2E1, oxidative and inflammatory parameters, liver fibrosis and portal pressure. CCl(4) significantly reduced serum levels of H(2)S, hepatic H(2)S production and CSE expression. NaHS attenuated CCl(4)-induced acute hepatotoxicity by supplementing exogenous H(2)S, which displayed anti-oxidative activities and inhibited the CYP2E1 activity. NaHS protected liver function, attenuated liver fibrosis, inhibited inflammation, and reduced the portal pressure, evidenced by the alterations of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), albumin, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and soluble intercellular adhesion molecule (ICAM)-1, liver histology, hepatic hydroxyproline content and α-smooth muscle actin (SMA) expression. PAG showed opposing effects to NaHS on most of the above parameters. Exogenous H(2)S attenuates CCl(4)-induced hepatotoxicity, liver cirrhosis and portal hypertension by its multiple functions including anti-oxidation, anti-inflammation, cytoprotection and anti-fibrosis, indicating that targeting H(2)S may present a promising approach, particularly for its prophylactic effects, against liver cirrhosis and portal hypertension.

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects

PubMed Central

Módis, Katalin; Bos, Eelke M; Calzia, Enrico; van Goor, Harry; Coletta, Ciro; Papapetropoulos, Andreas; Hellmich, Mark R; Radermacher, Peter; Bouillaud, Frédéric; Szabo, Csaba

2014-01-01

Emerging work demonstrates the dual regulation of mitochondrial function by hydrogen sulfide (H2S), including, at lower concentrations, a stimulatory effect as an electron donor, and, at higher concentrations, an inhibitory effect on cytochrome C oxidase. In the current article, we overview the pathophysiological and therapeutic aspects of these processes. During cellular hypoxia/acidosis, the inhibitory effect of H2S on complex IV is enhanced, which may shift the balance of H2S from protective to deleterious. Several pathophysiological conditions are associated with an overproduction of H2S (e.g. sepsis), while in other disease states H2S levels and H2S bioavailability are reduced and its therapeutic replacement is warranted (e.g. diabetic vascular complications). Moreover, recent studies demonstrate that colorectal cancer cells up-regulate the H2S-producing enzyme cystathionine β-synthase (CBS), and utilize its product, H2S, as a metabolic fuel and tumour-cell survival factor; pharmacological CBS inhibition or genetic CBS silencing suppresses cancer cell bioenergetics and suppresses cell proliferation and cell chemotaxis. In the last chapter of the current article, we overview the field of H2S-induced therapeutic ‘suspended animation’, a concept in which a temporary pharmacological reduction in cell metabolism is achieved, producing a decreased oxygen demand for the experimental therapy of critical illness and/or organ transplantation. Linked Articles This article is part of a themed issue on Mitochondrial Pharmacology: Energy, Injury & Beyond. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2014.171.issue-8 PMID:23991749

H2S and polysulfide metabolism: Conventional and unconventional pathways.

PubMed

Olson, Kenneth R

2018-03-01

It is now well established that hydrogen sulfide (H 2 S) is an effector of a wide variety of physiological processes. It is also clear that many of the effects of H 2 S are mediated through reactions with cysteine sulfur on regulatory proteins and most of these are not mediated directly by H 2 S but require prior oxidation of H 2 S and the formation of per- and polysulfides (H 2 S n , n = 2-8). Attendant with understanding the regulatory functions of H 2 S and H 2 S n is an appreciation of the mechanisms that control, i.e., both increase and decrease, their production and catabolism. Although a number of standard "conventional" pathways have been described and well characterized, novel "unconventional" pathways are continuously being identified. This review summarizes our current knowledge of both the conventional and unconventional. Copyright © 2017 Elsevier Inc. All rights reserved.

The Effects of Hub Drag, Solidity, Dual Rotation, and Number of Blades upon the Efficiency of High-Pitch Propellers

DTIC Science & Technology

1941-10-01

obJectivos. Pr.w eiited i n t h ” s rcpoi-t are thc ? rc.,:iG.tn of thesc? experiments wh’ch i , c e cslri-ied ou t f o r t h e K.WA i n t n...r shroude slig"lt1y overlapped thc spinners, clc3rcd them radially b) 0.05 inch an< t e rn ina te3 2.2 inches a f t of the ;:.me of ro?a t ion...o adinit t;ie c i r c u l a r Slade shanks and the Si i t ts of t h e blades tovched thc spimiers when scc a t iargs a q l e s . (Sce f i g

Synthesis, molecular properties estimations, and dual dopamine D2 and D3 receptor activities of Benzthiazole-based ligands.

NASA Astrophysics Data System (ADS)

Schübler, Moritz; Sadek, Bassem; Kottke, Tim; Weizel, Lilia; Stark, Holger

2017-09-01

Neurleptic drugs, e.g. aripiprazole, targeting the dopamine D2s and D3 receptors (D2sR and D3R) in the central nervous system are widely used in the treatment of several psychotic and neurodegenerative diseases. Therefore, a new series of benz[d]thiazole-based ligands (1-18) was synthesized by applying the bioisosteric approach derived from the selective D3Rs ligand BP-897 and its structurally related benz[d]imidazole derivatives. Herein, introduction of the benz[d]thiazole moiety was well tolerated by D2sR and D3R binding sites leading to antagonist affinities in the low nanomolar concentration range at both receptor subtypes. Further exploration of different substitution patterns at the benz[d]thiazole heterocycle and the basic 4-phenylpiperazine resulted in the discovery of high dually acting D2sR and D3R ligands. Moreover, the methoxy substitution at 2-position of 4-phenylpiperazine resulted in significantly (22-fold) increased D2sR binding affinity as compared to the parent ligand BP-897, and improved physicochemical and drug-likeness properties of ligands 1-9. However, the latter structural modifications failed to improve the drug-able properties in ligands having un-substituted 4-phenylpiperazine analogues (10-18). Accordingly, compound 7 showed in addition to high dual affinity at the D2sR and D3R (Ki (hD2SR) = 2.8 ± 0.8 nM; Ki (hD3R) = 3.0 ± 1.6 nM), promising clogS, clogP, LE (hD2sR, hD3R), LipE (hD2sR, hD3R), and drug-likeness score values of -4.7, 4.2, (0.4, 0.4), (4.4, 4.3), and 0.7, respectively. Also, the deaminated analogue 8 (Ki (hD2SR) = 3.2 ± 0.4 nM; Ki (hD3R) = 8.5 ± 2.2 nM) revealed clogS, clogP, LE (hD2sR, hD3R), LipE (hD2sR, hD3R) and drug-likeness score values of -4.7, 4.2, (0.4, 0.4), (3.9, 3.5), and 0.4, respectively. The results observed for the newly developed benz[d]thiazole-based ligands 1-18 provide clues for the diversity in structure activity relationships (SARs) at the D2sR and D3R subtypes.

A Study of the Jettisoning of JP-4 Fuel in the Atmosphere

DTIC Science & Technology

1975-11-01

t e r m i n e d by m e a s u r i n g the s tagna t ion p r e s s u r e with a pitot probe , shown in Fig. 21, with the s p h e r i c a l t...ip. The rod loca ted to the r igh t of the pitot probe was loca ted in the s a m e photographic plane as the suspended J P - 4 drop- le t...of Atomiza t ion in C a r b u r e t o r s . " NACA TM 518, 1929. 13. Lapple , C. E . , Henry , J . P . , J r . , and Blake, D. E. " A t o

Preliminary Inventory in the Early Coma of Comet 67P/Churyumov-Gerasimenko

NASA Astrophysics Data System (ADS)

Calmonte, Ursina; Altwegg, Kathrin; Le Roy, Léna; Rubin, Martin; Berthelier, Jean-Jacques; De Keyser, Johan; Fiethe, Björn; Fuselier, Steve A; Combi, Mike

2014-11-01

After a 10-year journey, the European Space Agency’s Rosetta mission encountered its target comet Churyumov-Gerasimenko. Rosetta will accompany the comet to perihelion and beyond. On board the Rosetta spacecraft is the ROSINA (Rosetta Orbiter Spectrometer for Ion and Neutral Analysis) experiment. ROSINA consists of a pressure sensor and two complementary mass spectrometers. One is the Double Focusing Mass Spectrometer, which has high dynamic range and a mass resolution m/Δm = 3000 at 1% peak height (m/Δm = 9000 at 50% peak height) at mass 28 amu/q. It is therefore well suited to detect minor species in the lower mass range up to mass 140 amu [1].ROSINA has been taking data since May 2014 and first signals of the comet were detected at the beginning of August. We will present a preliminary inventory of species seen by ROSINA in the early coma of comet Churyumov-Gerasimenko.References[1] Balsiger, H., Altwegg, K., Bochsler, P., Eberhardt, P., Fischer, J., Graf, S., Jäckel, A., Kopp, E., Langer, U., Mildner, M., Müller, J., Riesen, T., Rubin, M., Scherer, S., Wurz, P., Wüthrich, S., Arijs, E., Delanoye, S., de Keyser, J., Neefs, E., Nevejans, D., Rème, H., Aoustin, C., Mazelle, C., Médale, J.-L., Sauvaud, J.A., Berthelier, J.-J., Bertaux, J.-L., Duvet, L., Illiano, J.-M., Fuselier, S.A., Ghielmetti, A.G., Magoncelli, T., Shelley, E.G., Korth, A., Heerlein, K., Lauche, H., Livi, S., Loose, A., Mall, U., Wilken, B., Gliem, F., Fiethe, B., Gombosi, T.I., Block, B., Carignan, G.R., Fisk, L.A., Waite, J.H., Young, D.T. and Wollnik, H.,. Rosina Rosetta Orbiter Spectrometer for Ion and Neutral Analysis, Space Science Reviews 128, pp745-801, 2007.

Inactivation by lemon juice of Escherichia coli O157:H7, Salmonella Enteritidis, and Listeria monocytogenes in beef marinating for the ethnic food kelaguen.

PubMed

Yang, Jian; Lee, Delores; Afaisen, Shayna; Gadi, Rama

2013-01-01

Lemon juice, a major source of acidulant citric acid, is frequently used in the preparation of ethnic foods. Raw or partially cooked meats are marinated with lemon juice in the preparation of a popular Chamorro dish called kelaguen, which is, unfortunately, strongly associated with foodborne illness outbreaks in Guam. We investigated the efficacy of lemon juice in reducing numbers of Escherichia coli O157:H7, Salmonella Enteritidis, and Listeria monocytogenes at stationary phase during marination. Beef inoculated with a three-strain mixture of E. coli O157:H7, S. Enteritidis, or L. monocytogenes at 10(6)CFU/mL was marinated with lemon juice from 0.2 to 10mL/g for 48h at 28°C. The decline of the pathogens during marination exhibited various degrees of deviation from first-order kinetics. Based on calculations with both linear regression and Weibull models, the decimal reduction time (4-D values) over the range of lemon concentrations was 366-5.1h for E. coli O157:H7, 282-2.4h for S. Enteritidis, and 104-2.4h for L. monocytogenes, indicating that E. coli O157:H7 was the most lemon-juice-resistant of the three. The pathogen reduction time (log 4-D values) plotted against undissociated titratable citric acid exhibited a biphasic pattern. The pathogen reduction time (log 4-D or δ values) was linearly correlated with the pH of the marinating beef (R(2)=0.92 to 0.98). The Z(pH) values (pH dependence of death rate) with beef marination were 1.03 for E. coli O157:H7, 0.92 for S. Enteritidis, and 1.29 for L. monocytogenes, indicating that L. monocytogenes was the most pH resistant of the three. L. monocytogenes exhibited less resistance to lemon juice than S. Enteritidis at pH of 3.5-4.4 but more resistance at pH of 2.6-2.8. In addition, at 4°C, all three pathogens exhibited 4-D values 1.7-4.1 times greater than those at 24°C at 5mL lemon juice/g beef. In conclusion, the usual beef marinating practice for kelaguen preparation (<0.5mL lemon juice/g beef for 1-12h) did not sufficiently inactivate E. coli O157:H7, S. Enteritidis, and L. monocytogenes to meet minimum food-safety requirements. To reduce the risk of kelaguen-associated foodborne illness, kelaguen preparation must include heat treatment in addition to marination with lemon juice. Published by Elsevier B.V.

Face Detection and Modeling for Recognition

DTIC Science & Technology

2002-01-01

gi st er ed ra n ge an d co lo r im ag es . 16 F ig u re 1. 12 . S y st em d ia gr...it h an d w it h ou t th e tr an sf or m ar e sh ow n . F or ea ch ex am p le , th e im ag es sh ow n in th e fi rs t co lu m n ar e sk in re gi on s...software/products /perflib/ipl/index.htm>. [187] Intel Open Source Computer Vision Library, <http://developer.intel.com/ soft- ware/opensource/cvfl/ opencv

An Investigation of Aircraft Heaters. 2 - Measured and Predicted Performance

DTIC Science & Technology

1942-10-01

of a cent r i fuga l exhaust f an located, downstream from the heat exchanger. The r a t e pf exhaust gas flow w a s measured by means of a...p a r t i a l Hohlrawns ( idea l absorber). Further inspecfion o f t a b l e I shows that t h e rad ian t heat t r ans fe r from the oGter...pressure drop at any o ther temperature T is de - s i red , I For d i r e c t comparison to t h e isothermal data which were were correct

Genetics Home Reference: MyD88 deficiency

MedlinePlus

... L, Al-Muhsen S, Al-Hajjar S, Al-Ghonaium A, Day-Good NK, Holland SM, Gallin JI, Chapel H, Speert DP, Rodriguez-Gallego C, Colino E, Garty BZ, Roifman C, Hara T, Yoshikawa H, Nonoyama S, Domachowske J, Issekutz AC, Tang M, Smart J, Zitnik SE, ...

Colonization and Containment of Hyalomma Marginatum Rufipes for Studies on the Transmission of Crimean-Congo Hemorrhagic Fever

DTIC Science & Technology

1987-07-31

tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe and Africa. J. Med. Entomol. 15: 307-417. Hoogstraal, H., M. N. Kaiser, M. A. Taylor, S. Gaber ...N. Kaiser, M. A. Taylor, E. Guindy, and S. Gaber . 1963. Tick (Ixodoidea) on birds migrating from Europe and Asia to Africa, 1959-1961. IBID. Pegram...Hoogstraal, H Traylor, M.A., Gaber , S., Malakatis, G., Guindy, E. & Relmy, 1. 1964 ricks (Ixodidae) on migrating birds in Eg ypt, Spring and Fall

Ab initio investigation of electron capture by Cl{sup 7+} ions from H

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, L. B.; Stancil, P. C.; Watanabe, A.

2007-08-15

An investigation of charge transfer in collisions of ground-state Cl{sup 7+} with H has been conducted based on a fully quantum-mechanical molecular-orbital close-coupling (QMOCC) approach. The charge-transfer process Cl{sup 7+}({sup 1}S)+H{yields}Cl{sup 6+}(2p{sup 6}nl {sup 2}S,{sup 2}P{sup o},{sup 2}D,{sup 2}F{sup o},{sup 2}G)+H{sup +} with n=5 and 6 is taken into account for collision energies between 10{sup -4} eV/u and 1 keV/u. The relevant adiabatic potentials and nonadiabatic coupling matrix elements for the ClH{sup 7+} system are evaluated with the configuration-interaction method. The investigation shows that electron capture into the 5d, 5f, 5g, and 6p states dominates for collision energies less thanmore » {approx}1 eV/u, while above 100 eV/u the 5s, 5p, 5d, and 6p are the primary capture channels. Comparison with experimental data for collisions of Cl{sup 7+}({sup 1}S) with D reveals a discrepancy over the full range of measured energies (5-430 eV/u), while no significant isotope effect is found for QMOCC calculations with deuterium. Furthermore, comparison with a previous calculation of the one-electron N{sup 7+}+H system, as well as measurements of the multielectron Al{sup 7+}+H and Fe{sup 7+}+H systems, suggests that the electronic structure of the core has a non-negligible effect on the charge-transfer process. A one-electron model for relative l distributions is found to agree with the QMOCC results for n=5 between 100 and 1000 eV/u, but fails at lower collision energies. Finally, state-selective and total rate coefficients are given for temperatures between 10 and 200 000 K.« less

Electrostatic environment of hemes in proteins: pK(a)s of hydroxyl ligands.

PubMed

Song, Yifan; Mao, Junjun; Gunner, M R

2006-07-04

The pK(a)s of ferric aquo-heme and aquo-heme electrochemical midpoints (E(m)s) at pH 7 in sperm whale myoglobin, Aplysia myoblogin, hemoglobin I, heme oxygenase 1, horseradish peroxidase and cytochrome c oxidase were calculated with Multi-Conformation Continuum Electrostatics (MCCE). The pK(a)s span 3.3 pH units from 7.6 in heme oxygenase 1 to 10.9 in peroxidase, and the E(m)s range from -250 mV in peroxidase to 125 mV in Aplysia myoglobin. Proteins with higher in situ ferric aquo-heme pK(a)s tend to have lower E(m)s. Both changes arise from the protein stabilizing a positively charged heme. However, compared with values in solution, the protein shifts the aquo-heme E(m)s more than the pK(a)s. Thus, the protein has a larger effective dielectric constant for the protonation reaction, showing that electron and proton transfers are coupled to different conformational changes that are captured in the MCCE analysis. The calculations reveal a breakdown in the classical continuum electrostatic analysis of pairwise interactions. Comparisons with DFT calculations show that Coulomb's law overestimates the large unfavorable interactions between the ferric water-heme and positively charged groups facing the heme plane by as much as 60%. If interactions with Cu(B) in cytochrome c oxidase and Arg 38 in horseradish peroxidase are not corrected, the pK(a) calculations are in error by as much as 6 pH units. With DFT corrected interactions calculated pK(a)s and E(m)s differ from measured values by less than 1 pH unit or 35 mV, respectively. The in situ aquo-heme pK(a) is important for the function of cytochrome c oxidase since it helps to control the stoichiometry of proton uptake coupled to electron transfer [Song, Michonova-Alexova, and Gunner (2006) Biochemistry 45, 7959-7975].

Bisphosphonate-ciprofloxacin bound to Skelite is a prototype for enhancing experimental local antibiotic delivery to injured bone.

PubMed

Buxton, T B; Walsh, D S; Harvey, S B; McPherson, J C; Hartmann, J F; Plowman, K M

2004-09-01

The risk of osteomyelitis after open bone fracture may be reduced by locally applied antibiotics. ENC-41-HP (E41), which comprises ciprofloxacin linked to a 'bone seeking' bisphosphonate, loaded on to carrier Skelite calcium phosphate granules (E41-Skelite) has favourable in vitro characteristics for application to wounded bone. This study assessed E41-Skelite in a rat model of acute tibial osteomyelitis. Mechanically induced tibial troughs were contaminated with approximately log10 4 colony forming units (c.f.u.) of Staphylococcus aureus (Cowan 1 strain) 'resistant' to E41 (minimum inhibitory concentration 8-16 microg/ml), lavaged and packed with Skelite alone, or with E41-Skelite slurry. Animals were killed at 24 h (n = 62), 72 h (n = 46) or 14 days (n = 12), and each tibia was assessed for S. aureus load (c.f.u./g tibia) and histological appearance (14 days only). At 24 and 72 h, the tibias of rats treated with E41-Skelite (n = 54) had a significantly lower mean (s.e.m.) load of S. aureus than animals that received Skelite alone (n = 54): log10 3.6(0.2) versus 6.4(0.1) c.f.u./g respectively at 24 h (P < 0.001, Mann-Whitney rank sum test) and log10 4.4(0.2) versus 6.6(0.1) c.f.u./g at 72 h (P < 0.001). At 14 days, E41-Skelite-treated tibias had fewer bacteria, no signs of osteomyelitis and histological signs of healing. E41-Skelite, a prototype granulated topical antibiotic delivery system, reduced the development of infection in experimental bone wounds. Copyright 2004 British Journal of Surgery Society Ltd.

Interpretation of high rate dust measurements with the Cassini dust detector CDA

NASA Astrophysics Data System (ADS)

Kempf, Sascha

2008-03-01

For two years the cosmic dust analyser (CDA) onboard the Cassini spacecraft has been exploring the dust environment of Saturn [Srama, R., Kempf, S., Moragas-Klostermeyer, G., Helfert, S., Ahrens, T. J., Altobelli, N., Auer, S., Beckmann, U., Bradley, J.G., Burton, M., Dikarev, V.V., Economou, T., Fechtig, H., Green, S.F., Grande, M., Havnes, O., Hillier, J.K., Horanyi, M., Igenbergs, E., Jessberger, E.K., Johnson, T.V., Krüger, H., Matt, G., McBride, N., Mocker, A., Lamy, P., Linkert, D., Linkert, G., Lura, F., McDonnell, J.A.M., Möhlmann, D., Morfill, G.E., Postberg, F., Roy, M., Schwehm, G.H., Spahn, F., Svestka, J., Tschernjawski, V., Tuzzolino, A.J., Wäsch, R., Grün, E., 2006. In situ dust measurements in the inner Saturnian system. Planet. Space Sci. 54, 967-987]. One major goal of the CDA instruments is to investigate Saturn's enigmatic E ring - the largest known planetary ring of the solar system. The sophisticated main detector (dust analyser - DA) of CDA is rather slow when processing the impact data, and limits the detectable number of impacts to 60min-1 [Srama, R., Ahrens, T., Altobelli, N., Auer, S., Bradley, J., Burton, M., Dikarev, V., Economou, T., Fechtig, H., Görlich, M., Grande, M., Graps, A., Grün, E., Havnes, O., Helfert, S., Horányi, M., Igenbergs, E., Jeßberger, E., Johnson, T., Kempf, S., Krivov, A., Krüger, H., Mocker-Ahlreep, A., Moragas-Klostermeyer, G., Lamy, P., Landgraf, M., Linkert, D., Linkert, G., Lura, F., McDonnel, J., Möhlmann, D., Morfill, G., Müller, M., Roy, M., Schäfer, G., Schlotzhauer, G., Schwehm, G., Spahn, F., Stübig, M., Svestka, J., Tschernjawski, V., Tuzzolino, A., Wäsch, R., Zook, H., 2004. The Cassini cosmic dust analyser. Space Sci. Rev. 114, 465-518]. However, measurements by the CDA high rate detector (HRD) imply that the DA impact rates in the inner core of the E ring exceed 1000min-1. Clearly, to investigate dust-rich environments with the DA requires knowledge about the instrument performance at high impact rates. In this paper, we study the dependence of the number of detected impacts on the average impact rate arising from a Poisson process. We demonstrate the validity of the resulting expressions by comparing them with Monte Carlo (MC) simulations of the DA performance. We argue that DA measurements provide meaningful impact rate estimates even if the DA detects slightly less than 60 impacts per minute. Finally, we apply the derived expressions to a DA E ring measurement.

Severe Weather Guide - Mediterranean Ports. 2. Naples

DTIC Science & Technology

1988-01-01

Include Security Classification) S^ere Weather Guide - Mediterranean Ports - 2. Naples (U) ? SONAi <^UTHOR(S) .■/ L,^glebretson, Ronald E. (LCDR...AN ( j. ) HIJ-H F’B (2i 040200 ■ CI ’ 3) (U) C A (b) o I..; i E W C E A F’ P L. IC A T.[ G N Ei IN ! E R N...threatened try actual or -forecast 51 r D n q w i n d s , n i g n a e a s , r s s t r i c t e d v i s i D1111 y o i- thunderstcjrms m the port

Tripolar Stability: The Future of Nuclear Relations Among the United States, Russia, and China

DTIC Science & Technology

2002-09-01

I N S T I T U T E F O R D E F E N S E A N A L Y S E S D E F E N S E T H R E A T R E D U C T I O N A G E N C Y Tripolar Stability: The Future of... Tripolar Stability: The Future of Nuclear Relations Among the United States, Russia, and China Brad Roberts PREFACE Since the creation of the...here were first sketched out in a symposium convened at IDA on July 28 on nuclear tripolarity , where thoughtful presentations were made on facets

S K-edge XAS and DFT Calculations on Square Planar NiII-thiolate Complexes: Effects of Active and Passive H-bonding

PubMed Central

Dey, Abhishek; Green, Kayla N.; Jenkins, Roxanne M.; Jeffrey, Stephen P.; Darensbourg, Marcetta; Hodgson, Keith O.; Hedman, Britt; Solomon, Edward I.

2008-01-01

S K-edge XAS for a low-spin NiII-thiolate complex shows a 0.2 eV shift to higher pre-edge energy but no change in Ni-S bond covalency upon H-bonding. This is different from the H-bonding effect we observed in high spin FeIII-thiolate complexes where there is a significant decrease in Fe-S bond covalency but no change in energy due to H-bonding (Dey, A.; Okamura, T.-A.; Ueyama, N.; Hedman, B.; Hodgson, K. O.; Solomon, E. I. J. Am. Chem. Soc.; 2005; 127, 12046-12053.). These differences were analyzed using DFT calculations and the results indicate that two different types of H-bonding interactions are possible in metal-thiolate systems. In the high-spin FeIII-thiolate case, the H-bonding involves a thiolate donor orbital which is also involved in bonding with the metal (active), while in the low-spin NiII-thiolate the orbital involved in H-bonding is non-bonding with respect to the M-S bonding (passive). The contributions of active and passive H-bonds to the reduction potential and Lewis acid properties of a metal center are evaluated. PMID:17949080

A Major Upgrade of the H.E.S.S. Cherenkov Cameras

NASA Astrophysics Data System (ADS)

Lypova, Iryna; Giavitto, Gianluca; Ashton, Terry; Balzer, Arnim; Berge, David; Brun, Francois; Chaminade, Thomas; Delagnes, Eric; Fontaine, Gerard; Füßling, Matthias; Giebels, Berrie; Glicenstein, Jean-Francois; Gräber, Tobias; Hinton, Jim; Jahnke, Albert; Klepser, Stefan; Kossatz, Marko; Kretzschmann, Axel; Lefranc, Valentin; Leich, Holger; Lüdecke, Hartmut; Manigot, Pascal; Marandon, Vincent; Moulin, Emmanuel; de Naurois, Mathieu; Nayman, Patrick; Ohm, Stefan; Penno, Marek; Ross, Duncan; Salek, David; Schade, Markus; Schwab, Thomas; Simoni, Rachel; Stegmann, Christian; Steppa, Constantin; Thornhill, Julian; Toussnel, Francois

2017-03-01

The High Energy Stereoscopic System (H.E.S.S.) is an array of imaging atmospheric Cherenkov telescopes (IACTs) located in Namibia. It was built to detect Very High Energy (VHE, >100 GeV) cosmic gamma rays, and consists of four 12 m diameter Cherenkov telescopes (CT1-4), built in 2003, and a larger 28 m telescope (CT5), built in 2012. The larger mirror surface of CT5 permits to lower the energy threshold of the array down to 30 GeV. The cameras of CT1-4 are currently undergoing an extensive upgrade, with the goals of reducing their failure rate, reducing their readout dead time and improving the overall performance of the array. The entire camera electronics has been renewed from ground-up, as well as the power, ventilation and pneumatics systems, and the control and data acquisition software. Technical solutions forseen for the next-generation Cherenkov Telescope Array (CTA) observatory have been introduced, most notably the readout is based on the NECTAr analog memory chip. The camera control subsystems and the control software framework also pursue an innovative design, increasing the camera performance, robustness and flexibility. The CT1 camera has been upgraded in July 2015 and is currently taking data; CT2-4 will upgraded in Fall 2016. Together they will assure continuous operation of H.E.S.S at its full sensitivity until and possibly beyond the advent of CTA. This contribution describes the design, the testing and the in-lab and on-site performance of all components of the newly upgraded H.E.S.S. camera.

Annual Research Progress Report, Fiscal Year 1983,

DTIC Science & Technology

1983-10-01

Liver Plasma Membranes. Acceoted by Endocrinology, Sep 83. Submitted for Publication: Friedl, K.E. and Plymate, S.R.: Effects of Obesity on...i4c)ttle Feed and the Effect of Lactat ion i-i :’ost 0-tarti1u Wei-ght 1 ,oss. Presente.i to 10t h Anniversary Family Pract ico \\Iumni C’onterence...Madiga n Army Med icai C’enter, Tacorma, WA, Jan 1 . DEPARTME.N1 ()F MEDICINE Fincher, M.E., Little, J.S., PLymate, H.R. and Fariss, H.L.: Effect of

Mitigation of Confined Explosion Effects by Placing Water in Proximity of Explosives

DTIC Science & Technology

1992-08-01

fo rced conc re t e wa l l s and equlpment door; a s loped , f r a n g i b l e , cor ruga ted metal roof; and a smal l a t t ached s t r...r b lanket a re shown i n F igure 1. b. Replace t h e e x i s t i n g cor ruga ted metal roof wi th a p r e c a s t , R/concrete roo f

Genetic sharing and heritability of paediatric age of onset autoimmune diseases

PubMed Central

Li, Yun R.; Zhao, Sihai D.; Li, Jin; Bradfield, Jonathan P.; Mohebnasab, Maede; Steel, Laura; Kobie, Julie; Abrams, Debra J.; Mentch, Frank D.; Glessner, Joseph T.; Guo, Yiran; Wei, Zhi; Connolly, John J.; Cardinale, Christopher J.; Bakay, Marina; Li, Dong; Maggadottir, S. Melkorka; Thomas, Kelly A.; Qui, Haijun; Chiavacci, Rosetta M.; Kim, Cecilia E.; Wang, Fengxiang; Snyder, James; Flatø, Berit; Førre, Øystein; Denson, Lee A.; Thompson, Susan D.; Becker, Mara L.; Guthery, Stephen L.; Latiano, Anna; Perez, Elena; Resnick, Elena; Strisciuglio, Caterina; Staiano, Annamaria; Miele, Erasmo; Silverberg, Mark S.; Lie, Benedicte A.; Punaro, Marilynn; Russell, Richard K.; Wilson, David C.; Dubinsky, Marla C.; Monos, Dimitri S.; Annese, Vito; Munro, Jane E.; Wise, Carol; Chapel, Helen; Cunningham-Rundles, Charlotte; Orange, Jordan S.; Behrens, Edward M.; Sullivan, Kathleen E.; Kugathasan, Subra; Griffiths, Anne M.; Satsangi, Jack; Grant, Struan F. A.; Sleiman, Patrick M. A.; Finkel, Terri H.; Polychronakos, Constantin; Baldassano, Robert N.; Luning Prak, Eline T.; Ellis, Justine A.; Li, Hongzhe; Keating, Brendan J.; Hakonarson, Hakon

2015-01-01

Autoimmune diseases (AIDs) are polygenic diseases affecting 7–10% of the population in the Western Hemisphere with few effective therapies. Here, we quantify the heritability of paediatric AIDs (pAIDs), including JIA, SLE, CEL, T1D, UC, CD, PS, SPA and CVID, attributable to common genomic variations (SNP-h2). SNP-h2 estimates are most significant for T1D (0.863±s.e. 0.07) and JIA (0.727±s.e. 0.037), more modest for UC (0.386±s.e. 0.04) and CD (0.454±0.025), largely consistent with population estimates and are generally greater than that previously reported by adult GWAS. On pairwise analysis, we observed that the diseases UC-CD (0.69±s.e. 0.07) and JIA-CVID (0.343±s.e. 0.13) are the most strongly correlated. Variations across the MHC strongly contribute to SNP-h2 in T1D and JIA, but does not significantly contribute to the pairwise rG. Together, our results partition contributions of shared versus disease-specific genomic variations to pAID heritability, identifying pAIDs with unexpected risk sharing, while recapitulating known associations between autoimmune diseases previously reported in adult cohorts. PMID:26450413

The Army Air Forces in World War II. Volume 7. Services Around the World

DTIC Science & Technology

1983-01-01

la., Maj. Gen. J. S . Stowell to Frank H. Heck, I I Sept. 1952. 64. Schedules included in SATD SOP for Green Proj., in Hist. SATD, May- 65. Ltr...E S I N W O R L D W A R I I it was the first war truly world wide in geographical scope but in that for the first time combat operations were...various mechanical ailments calling for numerous modi- fications and was a hard plane to fly and to maintain. Vii T H E A R M Y A I R F O R C E S I

Considerations in Establishing an Economic Community of West African States’ Defense Pact.

DTIC Science & Technology

1987-03-01

AU-AWC-87-062 UNCLASSIFIED F/G 5/2 ElhEEEEElhhhlE E ~hEEEllEllhlE IEEEEEEEllEEEE EIIEEEEEEEEEEE EllEEEEEE~lEEE ElllEEllEIh~hE 11111L2 1.0 1 6 Ma...33 Political Instability ....... .. .. . .. o .. . .. 34 Economnics ....... ... *... e ... ......... 34 A c r s. . . . . . o...41 Role and Policy.. .... . .. o . .. . .. . . .. . .. 41 Economic............................ 42 Accords, France and Libya... .......... 43 N i g e

A low-toxic site-directed mutant of Clostridium perfringens ε-toxin as a potential candidate vaccine against enterotoxemia.

PubMed

Li, Qing; Xin, Wenwen; Gao, Shan; Kang, Lin; Wang, Jinglin

2013-11-01

Clostridium perfringens epsilon toxin (ETX), one of the most potent toxins known, is a potential biological weapon; therefore, the development of an effective vaccine is important for preventing intoxication or disease by ETX. In this study, genetically detoxified epsilon toxin mutants were developed as candidate vaccines. We used site-directed mutagenesis to mutate the essential amino acid residues (His106, Ser111 and Phe199). Six site-directed mutants of ETX (mETX (H106P) , mETX (S111H) , mETX (S111Y) , mETX (F199H) , mETX (F199E) , mETX (S111YF199E) ) were generated and then expressed in Escherichia coli. Both mETX (F199E) and mETX (H106P) with low or non-cytotoxicity that retained their immunogenicity were selected to immunize mice 3 times, and the mouse survival data were recorded after challenging with recombinant wild-type ETX. mETX (F199E) induces the same protection as mETX (H106P) , which was reported previously as a promising toxin mutant for vaccine, and both of them could protect immunized mice against a 100× LD₅₀ dose of active wild-type recombinant ETX. This work showed that mETX (F199E) is another promising candidate vaccine against enterotoxemia and other diseases caused by ETX.

Biotechnology Process Engineering Center at MIT Home

Science.gov Websites

; < N o r m a l CJ aJ mH sH tH D A@òÿ¡ D D e f a u l t P a r a g r a p h F o n t R i@óÿ³ R T a b l e N o r m a l ö 4Ö ; l 4Ö aö ( k@ôÿÁ ( N o L i s t º@ ¦

Probability of Detection Study to Assess the Performance of Nondestructive Inspection Methods for Wind Turbine Blades.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roach, Dennis P.; Rice, Thomas M.; Paquette, Joshua

Wind turbine blades pose a unique set of inspection challenges that span from very thick and attentive spar cap structures to porous bond lines, varying core material and a multitude of manufacturing defects of interest. The need for viable, accurate nondestructive inspection (NDI) technology becomes more important as the cost per blade, and lost revenue from downtime, grows. NDI methods must not only be able to contend with the challenges associated with inspecting extremely thick composite laminates and subsurface bond lines, but must also address new inspection requirements stemming from the growing understanding of blade structural aging phenomena. Under itsmore » Blade Reliability Collaborative program, Sandia Labs quantitatively assessed the performance of a wide range of NDI methods that are candidates for wind blade inspections. Custom wind turbine blade test specimens, containing engineered defects, were used to determine critical aspects of NDI performance including sensitivity, accuracy, repeatability, speed of inspection coverage, and ease of equipment deployment. The detection of fabrication defects helps enhance plant reliability and increase blade life while improved inspection of operating blades can result in efficient blade maintenance, facilitate repairs before critical damage levels are reached and minimize turbine downtime. The Sandia Wind Blade Flaw Detection Experiment was completed to evaluate different NDI methods that have demonstrated promise for interrogating wind blades for manufacturing flaws or in-service damage. These tests provided the Probability of Detection information needed to generate industry-wide performance curves that quantify: 1) how well current inspection techniques are able to reliably find flaws in wind turbine blades (industry baseline) and 2) the degree of improvements possible through integrating more advanced NDI techniques and procedures. _____________ S a n d i a N a t i o n a l L a b o r a t o r i e s i s a m u l t i m i s s i o n l a b o r a t o r y m a n a g e d a n d o p e r a t e d b y N a t i o n a l T e c h n o l o g y a n d E n g i n e e r i n g S o l u t i o n s o f S a n d i a , L L C , a w h o l l y o w n e d s u b s i d i a r y o f H o n e y w e l l I n t e r n a t i o n a l , I n c . , f o r t h e U . S . D e p a r t m e n t o f E n e r g y ' s N a t i o n a l N u c l e a r S e c u r i t y A d m i n i s t r a t i o n u n d e r c o n t r a c t D E - N A 0 0 0 3 5 2 5 .« less

H-Field, E-Field, and Combined Field Solutions for Bodies of Revolution

DTIC Science & Technology

1977-03-01

thle Report) A - Approved for I)ublic release; distribution unlimited 17. DISTRIBUTION STATEMENT (of the abetrect entered fIn Block 20, If differentI ...transfer the differential operator on 0 in (49) to Wp Since S is closed,.+.ffi" ff V s (P W) ds 0 (51) S where W denotes W Now, the representation V...Se Cti iOn V , i t: i SSlIo071 t h at IeIIC liTlTIiý(O 0 0tt IS e quI a IIor, as-, ocK a te d w ith th el co-b i n1e d f e I d -o 1mnitIl a t 1 1) os n

A search for new supernova remnant shells in the Galactic plane with H.E.S.S.

NASA Astrophysics Data System (ADS)

H. E. S. S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Andersson, T.; Angüner, E. O.; Arakawa, M.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Becker Tjus, J.; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bonnefoy, S.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Capasso, M.; Carr, J.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Coffaro, M.; Colafrancesco, S.; Cologna, G.; Condon, B.; Conrad, J.; Cui, Y.; Davids, I. D.; Decock, J.; Degrange, B.; Deil, C.; Devin, J.; deWilt, P.; Dirson, L.; Djannati-Ataï, A.; Domainko, W.; Donath, A.; Drury, L. O.'C.; Dutson, K.; Dyks, J.; Edwards, T.; Egberts, K.; Eger, P.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Funk, S.; Füßling, M.; Gabici, S.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Gottschall, D.; Goyal, A.; Grondin, M.-H.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holch, T. L.; Holler, M.; Horns, D.; Ivascenko, A.; Iwasaki, H.; Jacholkowska, A.; Jamrozy, M.; Janiak, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jogler, T.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katsuragawa, M.; Katz, U.; Kerszberg, D.; Khangulyan, D.; Khélifi, B.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Kraus, M.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lefranc, V.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morå, K.; Moulin, E.; Murach, T.; Nakashima, S.; de Naurois, M.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Öttl, S.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Richter, S.; Rieger, F.; Romoli, C.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Saito, S.; Salek, D.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Simoni, R.; Sol, H.; Spanier, F.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stycz, K.; Sushch, I.; Takahashi, T.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tsuji, N.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zaborov, D.; Zacharias, M.; Zanin, R.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Żywucka, N.; Bamba, A.; Fukui, Y.; Sano, H.; Yoshiike, S.

2018-04-01

A search for new supernova remnants (SNRs) has been conducted using TeV γ-ray data from the H.E.S.S. Galactic plane survey. As an identification criterion, shell morphologies that are characteristic for known resolved TeV SNRs have been used. Three new SNR candidates were identified in the H.E.S.S. data set with this method. Extensive multiwavelength searches for counterparts were conducted. A radio SNR candidate has been identified to be a counterpart to HESS J1534-571. The TeV source is therefore classified as a SNR. For the other two sources, HESS J1614-518 and HESS J1912+101, no identifying counterparts have been found, thus they remain SNR candidates for the time being. TeV-emitting SNRs are key objects in the context of identifying the accelerators of Galactic cosmic rays. The TeV emission of the relativistic particles in the new sources is examined in view of possible leptonic and hadronic emission scenarios, taking the current multiwavelength knowledge into account.

PKS 2155-304 in July 2006: H.E.S.S. results and simultaneous multi-wavelength observations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lenain, Jean-Philippe; Boisson, Catherine; Sol, Helne

2008-12-24

The high-frequency-peaked BL Lac PKS 2155-304 is one of the brightest and best-studied VHE {gamma}-ray sources in the southern hemisphere. The High Energy Stereoscopic System (H.E.S.S.) has monitored PKS 2155-304 in 2006 and a multi-wavelength campaign involving X-ray, optical and radio observatories was triggered by the detection of an active state in July 2006, followed by the detection of two extraordinary flares on July, 28th and 30th, with peak fluxes {approx}100 times the usual values. We present results from the spectral and flux variability analysis of the VHE and simultaneous X-ray observations with Chandra during the second flare, as wellmore » as the detailed evolution of the VHE flux of PKS 2155-304 observed by H.E.S.S. in 2006. A study of flux correlations in the different frequency ranges during the second flare and the adjacent nights is discussed. We also present an interpretation of the active state of PKS 2155-304 in the framework of synchrotron self-Compton emission.« less

Simulating deep surveys of the Galactic Plane with the Advanced Gamma-ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Funk, Stefan; Digel, Seth

2009-05-01

The pioneering survey of the Galactic plane by H.E.S.S., together with the northern complement now underway with VERITAS, has shown the inner Milky Way to be rich in TeV-emitting sources; new source classes have been found among the H.E.S.S. detections and unidentified sources remain. In order to explore optimizations of the design of an Advanced Gamma-ray Imaging System (AGIS)-like instrument for survey science, we constructed a model of the flux and size distributions of Galactic TeV sources, normalized to the H.E.S.S. sources but extrapolated to lower flux levels. We investigated potential outcomes from a survey with the order of magnitude improvement in sensitivity and attendant improvement in angular resolution planned for AGIS. Studies of individual sources and populations found with such a sensitivity survey will advance understanding of astrophysical particle acceleration, source populations, and even high-energy cosmic rays via detection of the low-level TeV diffuse emission in regions of high cosmic-ray densitiy.

Boron Nitride Substrates for High Mobility Chemical Vapor Deposited Graphene

DTIC Science & Technology

2011-06-13

Hone, H. L. Stormer , and P. Kim, Phys. Rev. Lett. 101, 096802 2008. 5K. I. Bolotin, K. J. Sikes, Z. Jiang, M. Klima, G. Fudenberg, J. Hone, P. Kim, and...H. L. Stormer , Solid State Commun. 146, 351 2008. 6S. Berciaud, S. Ryu, L. E. Brus, and T. F. Heinz, Nano Lett. 9, 346 2009. 7S. Bae, H. Kim, Y

Increased flexibility in the use of exogenous lipoic acid by Staphylococcus aureus.

PubMed

Laczkovich, Irina; Teoh, Wei Ping; Flury, Sarah; Grayczyk, James P; Zorzoli, Azul; Alonzo, Francis

2018-04-16

Lipoic acid is a cofactor required for intermediary metabolism that is either synthesized de novo or acquired from environmental sources. The bacterial pathogen Staphylococcus aureus encodes enzymes required for de novo biosynthesis, but also encodes two ligases, LplA1 and LplA2, that are sufficient for lipoic acid salvage during infection. S. aureus also encodes two H proteins, GcvH of the glycine cleavage system and the homologous GcvH-L encoded in an operon with LplA2. GcvH is a recognized conduit for lipoyl transfer to α-ketoacid dehydrogenase E2 subunits, while the function of GcvH-L remains unclear. The potential to produce two ligases and two H proteins is an unusual characteristic of S. aureus that is unlike most other Gram positive Firmicutes and might allude to an expanded pathway of lipoic acid acquisition in this microorganism. Here, we demonstrate that LplA1 and LplA2 facilitate lipoic acid salvage by differentially targeting lipoyl domain-containing proteins; LplA1 targets H proteins and LplA2 targets α-ketoacid dehydrogenase E2 subunits. Furthermore, GcvH and GcvH-L both facilitate lipoyl relay to E2 subunits. Altogether, these studies identify an expanded mode of lipoic acid salvage used by S. aureus and more broadly underscore the importance of bacterial adaptations when faced with nutritional limitation. © 2018 John Wiley & Sons Ltd.

Modulation of Gain-of-function α6*-Nicotinic Acetylcholine Receptor by β3 Subunits*

PubMed Central

Dash, Bhagirathi; Lukas, Ronald J.

2012-01-01

We previously have shown that β3 subunits either eliminate (e.g. for all-human (h) or all-mouse (m) α6β4β3-nAChR) or potentiate (e.g. for hybrid mα6hβ4hβ3- or mα6mβ4hβ3-nAChR containing subunits from different species) function of α6*-nAChR expressed in Xenopus oocytes, and that nAChR hα6 subunit residues Asn-143 and Met-145 in N-terminal domain loop E are important for dominant-negative effects of nAChR hβ3 subunits on hα6*-nAChR function. Here, we tested the hypothesis that these effects of β3 subunits would be preserved even if nAChR α6 subunits harbored gain-of-function, leucine- or valine-to-serine mutations at 9′ or 13′ positions (L9′S or V13′S) in their second transmembrane domains, yielding receptors with heightened functional activity and more amenable to assessment of effects of β3 subunit incorporation. However, coexpression with β3 subunits potentiates rather than suppresses function of all-human, all-mouse, or hybrid α6(L9′S or V13′S)β4*- or α6(N143D+M145V)L9′Sβ2*-nAChR. This contrasts with the lack of consistent function when α6(L9′S or V13′S) and β2 subunits are expressed alone or in the presence of wild-type β3 subunits. These results provide evidence that gain-of-function hα6hβ2*-nAChR (i.e. hα6(N143D+M145V)L9′Shβ2hβ3 nAChR) could be produced in vitro. These studies also indicate that nAChR β3 subunits can be assembly partners in functional α6*-nAChR and that 9′ or 13′ mutations in the nAChR α6 subunit second transmembrane domain can act as gain-of-function and/or reporter mutations. Moreover, our findings suggest that β3 subunit coexpression promotes function of α6*-nAChR. PMID:22315221

Comparative Analysis of Routing Algorithms for Computer Networks

DTIC Science & Technology

1977-06-01

the ab ~l i tv of ~ to lower t h u(j+ l) - (j- ~- l ) objective funct ion upo n being included in the basis , but also - Rd Cost (‘P(j+ l ) ) is an...for exposi t ion of a s im i l a r proof . Steps 1 and 2 a n - b o o t s t r - ap p i n g successive diagonal and f i r s t o f f -d i agona l...An N x N ‘ next arc ’ m a t r : x , K = [x. ], ~ e s t ab l i shed , w h e r e x . - is the f i r s t arc on the c~~rr~~nt1] est imate of the

Detonation Wave Curvature, Corner Turning, and Unreacted Hugoniot of PBXN-111

DTIC Science & Technology

1992-03-19

ILl LA LU in 0 qR R q q (wwj) sn iavvI NONiAVM 13 NSWCDD/TR-92/164 E-- N H , H - t• tC) H- :: E4 E W .,1 0 v 01O H- LD P H H 44 Zo r4 11 tD 0o S+1 +1...K STEIN) 1 WASHINGTON DC 20301 SPSP (M FRANKEL) 1 SPRV CT FREDRTCKSON)J 1 ATTN I BLATSTEIN ( TD ) 1 SP (C MCFARLAND) I NAVAL SURFACE WARFARE CENTER...LIBRARY 1 HARRY DIAMOND LABORATORIES PRESIDENT 2800 POWDER MILL ROAD NAVAL WAR COLLEGE ADELPHI MD 20783 NEWPORT RI 02841 ATTN AMSLC TD (R VITALI) 1

First limits on the very-high energy gamma-ray afterglow emission of a fast radio burst. H.E.S.S. observations of FRB 150418

NASA Astrophysics Data System (ADS)

H.E.S.S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Andersson, T.; Angüner, E. O.; Arakawa, M.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Becker Tjus, J.; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Capasso, M.; Carr, J.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chalme-Calvet, R.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Chrétien, M.; Coffaro, M.; Colafrancesco, S.; Cologna, G.; Condon, B.; Conrad, J.; Cui, Y.; Davids, I. D.; Decock, J.; Degrange, B.; Deil, C.; Devin, J.; Dewilt, P.; Dirson, L.; Djannati-Ataï, A.; Domainko, W.; Donath, A.; Drury, L. O.'c.; Dutson, K.; Dyks, J.; Edwards, T.; Egberts, K.; Eger, P.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Funk, S.; Füßling, M.; Gabici, S.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Gottschall, D.; Goyal, A.; Grondin, M.-H.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holler, M.; Horns, D.; Ivascenko, A.; Iwasaki, H.; Jacholkowska, A.; Jamrozy, M.; Janiak, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jogler, T.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katsuragawa, M.; Katz, U.; Kerszberg, D.; Khangulyan, D.; Khélifi, B.; Kieffer, M.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Kraus, M.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lefranc, V.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morå, K.; Moulin, E.; Murach, T.; Nakashima, S.; de Naurois, M.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Öttl, S.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Reimer, A.; Reimer, O.; Renaud, M.; de Los Reyes, R.; Richter, S.; Rieger, F.; Romoli, C.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Saito, S.; Salek, D.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Simoni, R.; Sol, H.; Spanier, F.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stycz, K.; Sushch, I.; Takahashi, T.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tsuji, N.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zaborov, D.; Zacharias, M.; Zanin, R.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Żywucka, N.; Superb Collaboration; Jankowski, F.; Keane, E. F.; Petroff, E.

2017-01-01

Aims: Following the detection of the fast radio burst FRB150418 by the SUPERB project at the Parkes radio telescope, we aim to search for very-high energy gamma-ray afterglow emission. Methods: Follow-up observations in the very-high energy gamma-ray domain were obtained with the H.E.S.S. imaging atmospheric Cherenkov telescope system within 14.5 h of the radio burst. Results: The obtained 1.4 h of gamma-ray observations are presented and discussed. At the 99% C.L. we obtained an integral upper limit on the gamma-ray flux of Φγ(E > 350 GeV) < 1.33 × 10-8 m-2 s-1. Differential flux upper limits as function of the photon energy were derived and used to constrain the intrinsic high-energy afterglow emission of FRB 150418. Conclusions: No hints for high-energy afterglow emission of FRB 150418 were found. Taking absorption on the extragalactic background light into account and assuming a distance of z = 0.492 based on radio and optical counterpart studies and consistent with the FRB dispersion, we constrain the gamma-ray luminosity at 1 TeV to L < 5.1 × 1047 erg/s at 99% C.L.

Urban Terrain Analysis Training Aids

DTIC Science & Technology

1981-09-01

h a t o f Jeep- mounted TOW’S. These could be f i r e d from any f l o o r w i t h o u t f e a r of back b l a s t . Some cover and...stone cladding 2. Mass construction: stone 3. Mass construction: brick with stone veneer IV. Site 4: Rainier Bank 1 A. What is the class of window

Protecting Critical Rail Infrastructure

DTIC Science & Technology

2006-12-01

Gulliver.Trb.Org/Publications/Sr/Sr270.Pdf. 38. Allan J. DeBlasio, Terrance J. Regan, Margaret E . Zirker, Katherine S. Fichter, Kristin Lovejoy ...getrpt?GAO-04-598T. 4. Ibid. 5. Thomas H. Kean, Lee H. Hamilton, Richard Ben-Veniste, Fred F. Fielding, Jamie S. Gorelick, Slade Gorton, Bob Kerrey...Committee, Current and Projected National Security Threats to the United States, Vice Admiral Lowell E . Jacoby, United States Navy, Director, Defense

Production of 10S-hydroxy-8(E)-octadecenoic acid from oleic acid by whole recombinant Escherichia coli cells expressing 10S-dioxygenase from Nostoc punctiforme PCC 73102 with the aid of a chaperone.

PubMed

Kim, Min-Ji; Seo, Min-Ju; Shin, Kyung-Chul; Oh, Deok-Kun

2017-01-01

To increase the production of 10S-hydroxy-8(E)-octadecenoic acid from oleic acid by whole recombinant Escherichia coli cells expressing Nostoc punctiforme 10S-dioxygenase with the aid of a chaperone. The optimal conditions for 10S-hydroxy-8(E)-octadecenoic acid production by recombinant cells co-expressing chaperone plasmid were pH 9, 35 °C, 15 % (v/v) dimethyl sulfoxide, 40 g cells l -1 , and 10 g oleic acid l -1 . Under these conditions, recombinant cells co-expressing chaperone plasmid produced 7.2 g 10S-hydroxy-8(E)-octadecenoic acid l -1 within 30 min, with a conversion yield of 72 % (w/w) and a volumetric productivity of 14.4 g l -1 h -1 . The activity of recombinant cells expressing 10S-dioxygenase was increased by 200 % with the aid of a chaperone, demonstrating the first biotechnological production of 10S-hydroxy-8(E)-octadecenoic acid using recombinant cells expressing 10S-dioxygenase.

Chemical Composition and Evaluation of Nicotine, Tobacco Alkaloids, pH, and Selected Flavors in E-Cigarette Cartridges and Refill Solutions.

PubMed

Lisko, Joseph G; Tran, Hang; Stanfill, Stephen B; Blount, Benjamin C; Watson, Clifford H

2015-10-01

Electronic cigarette (e-cigarette) use is increasing dramatically in developed countries, but little is known about these rapidly evolving products. This study analyzed and evaluated the chemical composition including nicotine, tobacco alkaloids, pH, and flavors in 36 e-liquids brands from 4 manufacturers. We determined the concentrations of nicotine, alkaloids, and select flavors and measured pH in solutions used in e-cigarettes. E-cigarette products were chosen based upon favorable consumer approval ratings from online review websites. Quantitative analyses were performed using strict quality assurance/quality control validated methods previously established by our lab for the measurement of nicotine, alkaloids, pH, and flavors. Three-quarters of the products contained lower measured nicotine levels than the stated label values (6%-42% by concentration). The pH for e-liquids ranged from 5.1-9.1. Minor tobacco alkaloids were found in all samples containing nicotine, and their relative concentrations varied widely among manufacturers. A number of common flavor compounds were analyzed in all e-liquids. Free nicotine levels calculated from the measurement of pH correlated with total nicotine content. The direct correlation between the total nicotine concentration and pH suggests that the alkalinity of nicotine drives the pH of e-cigarette solutions. A higher percentage of nicotine exists in the more absorbable free form as total nicotine concentration increases. A number of products contained tobacco alkaloids at concentrations that exceed U.S. pharmacopeia limits for impurities in nicotine used in pharmaceutical and food products. © Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

U. S. Naval Forces, Vietnam Monthly Historical Summary for November 1969

DTIC Science & Technology

1970-01-01

D & E) LIST V (A) LIST VI (A 2&2, DI, E & H14) I .-’-.5 S2.2 ŕ 7 - UNCLASSWIFIE•.-. .. •. ’• -o- --. * --" U.~~~~ S . NAALFOCE Vi~ri...Vi V ’ ’-* 0S a,- 0 - 00 - _ d 0 00El IAC~ CV V V . ~ El ( V ( V ~i 500 GO en I A- s ’ ~ S ~-. otoU - 1 (12 a (Vs Eli a ( V -mc PE 0 - *~~i ss .8 E8.Ela 0...Nov. 7. S E S - -3 No v . 4 D . SEA FLOAT - l14 Nov. :E. SEA

Palyosulfonoceramides A and B: unique sulfonylated ceramides from the Brazilian zoanthids Palythoa caribaeorum and Protopalythoa variabilis.

PubMed

Almeida, Jose Gustavo L; Maia, Ana Isabel V; Wilke, Diego V; Silveira, Edilberto R; Braz-Filho, Raimundo; La Clair, James J; Costa-Lotufo, Leticia V; Pessoa, Otília Deusdenia L

2012-12-14

The zoanthids Palythoa caribaeorum and Protopalythoa variabilis are among the most abundant marine species along the Brazilian coast. We now report the isolation and structure elucidation of two unprecedented sulfonylated ceramides, palyosulfonoceramide A (1) and palyosulfonoceramide B (2) from specimens collected off Brazil's northeastern coast. The structures of 1 and 2 were established using a combination of NMR analyses, including: evaluation of 1H, 13C, ¹H--¹H COSY, ¹H--¹³C HSQC, ¹H--¹³C HMBC, and ¹H--¹⁵N HMBC NMR spectra, high-resolution mass spectrometry and chemical degradation. In addition, we also isolated the corresponding known ceramides, N-((2S,3R,4E,8E)-1, 3-dihydroxyoctadeca-4,8-dien-2-yl)-hexadecanamide (3) and N-((2S,3R,4E)-1,3-dihydroxy octadeca-4-en-2-yl)-hexadecanamide (4), which provided further support for the assignments of 1 and 2.

Geographical Information Extraction With Remote Sensing. Part I - Main Report.

DTIC Science & Technology

1998-08-01

Oude Waalsdorperweg 63 Date P0 Box 96864 2509 JG The Hague August 1998 The Netherlands Author(s) Phone +31 70 374 00 00 Dr A.C. van den Broek Fax +31 70...328 09 61 M. van Persie H.H.S. Noorbergen Dr G.J. Rijckenberg SSponsor HWO-COfHWO-KL N E R Project officer J. Rogge Affiliation KIN/IA - i All...Main report Auteur(s) Dr. A.C. van den Broek, Ir. M. van Persie, Ing. H.H.S. Noorberg~en, Dr. G.J. Rijkenberg Datum augustus 1998 Opdrachtnr

Making Riflemen from Mud: Restoring the Army’s Culture of Irregular Warfare (CSL Student Issue Paper, Volume S01-07, Jul 2007)

DTIC Science & Technology

2007-07-01

CSLC E N T E R f o r S T R AT E G I C L E A D E R S H I P Student Issue PaperCenter for Strategic Leadership, U.S...Matthew Batson was commanding L Troop, 4th U.S. Cavalry, during operations in the Philippines. Already recognized as an energetic and courageous officer...Said England unto Pharaoh, “You’ve had miracles before, When Aaron struck your rivers into blood; But if you watch the Sergeant he can show you

Influence of leaching conditions for ecotoxicological classification of ash.

PubMed

Stiernström, S; Enell, A; Wik, O; Hemström, K; Breitholtz, M

2014-02-01

The Waste Framework Directive (WFD; 2008/98/EC) states that classification of hazardous ecotoxicological properties of wastes (i.e. criteria H-14), should be based on the Community legislation on chemicals (i.e. CLP Regulation 1272/2008). However, harmonizing the waste and chemical classification may involve drastic changes related to choice of leaching tests as compared to e.g. the current European standard for ecotoxic characterization of waste (CEN 14735). The primary aim of the present study was therefore to evaluate the influence of leaching conditions, i.e. pH (inherent pH (∼10), and 7), liquid to solid (L/S) ratio (10 and 1000 L/kg) and particle size (<4 mm, <1 mm, and <0.125 mm), for subsequent chemical analysis and ecotoxicity testing in relation to classification of municipal waste incineration bottom ash. The hazard potential, based on either comparisons between element levels in leachate and literature toxicity data or ecotoxicity testing of the leachates, was overall significantly higher at low particle size (<0.125 mm) as compared to particle fractions <1mm and <4mm, at pH 10 as compared to pH 7, and at L/S 10 as compared to L/S 1000. These results show that the choice of leaching conditions is crucial for H-14 classification of ash and must be carefully considered in deciding on future guidance procedures in Europe. Copyright © 2013 Elsevier Ltd. All rights reserved.

Ring Opening Polymerization and Copolymerization of Cyclic Esters Catalyzed by Group 2 Metal Complexes Supported by Functionalized P-N Ligands.

PubMed

Harinath, Adimulam; Bhattacharjee, Jayeeta; Sarkar, Alok; Nayek, Hari Pada; Panda, Tarun K

2018-03-05

We report the preparation of alkali and alkaline earth (Ae) metal complexes supported by 2-picolylamino-diphenylphosphane chalcogenide [(Ph 2 P(=E)NHCH 2 (C 5 H 4 N)] [E = S (1-H); Se (2-H)] ligands. The treatment of the protic ligand, 1-H or 2-H, with alkali metal hexamethyldisilazides at room temperature afforded the corresponding alkali metal salts [M(THF) 2 (Ph 2 P(=E)NCH 2 (C 5 H 4 N)] [M = Li, E = S (3a), Se (3b)] and [{M(THF) n (Ph 2 P(=E)NCH 2 (C 5 H 4 N)} 2 ] [M = Na, E = S (4a), Se (4b); M = K, E = Se (5b)] in good yield. The homoleptic Ae metal complexes [κ 2 -(Ph 2 P(=Se)NCH 2 (C 5 H 4 N)Mg(THF)] (6b) and [κ 3 -{(Ph 2 P(=Se)NCH 2 (C 5 H 4 N)} 2 M(THF) n ] (M = Ca (7b), Sr (8b), Ba (9b)] were synthesized by the one-pot reaction of 2-H with [KN(SiMe 3 ) 2 ] and MI 2 in a 2:2:1 molar ratio at room temperature. The molecular structures of the protic-ligands 1-H and 2-H, as well as complexes 3a,b-5a,b and 6b-9b were established using single-crystal X-ray analysis. The Ae metal complexes 6b-9b were tested for ring-opening polymerization (ROP) of racemic lactide ( rac-LA) and copolymerization of rac-LA and ε-caprolactone (ε-CL) at room temperature. In the ROP of rac-LA, the calcium complex 7b exhibited high isoselectivity, with P i = 0.89, whereas both the barium and strontium complexes showed lower isoselectivity with P i = 0.78-0.62. In the copolymerization of rac-LA and ε-CL, both barium and strontium complexes proved to be efficient precatalysts for the formation of the block copolymer rac-LA-CL, but the reactivity of 9b was found to be better than that of 8b. All the polymers were fully characterized using differential scanning calorimetry, thermogravimetric analysis, and gel permeation chromatography analyses. Kinetic studies on the ROP reaction of LA confirmed that the rate of polymerization followed the order Ba ≫ Sr ≈ Ca.

Polarizabilities and hyperpolarizabilities for the atoms Al, Si, P, S, Cl, and Ar: Coupled cluster calculations.

PubMed

Lupinetti, Concetta; Thakkar, Ajit J

2005-01-22

Accurate static dipole polarizabilities and hyperpolarizabilities are calculated for the ground states of the Al, Si, P, S, Cl, and Ar atoms. The finite-field computations use energies obtained with various ab initio methods including Moller-Plesset perturbation theory and the coupled cluster approach. Excellent agreement with experiment is found for argon. The experimental alpha for Al is likely to be in error. Only limited comparisons are possible for the other atoms because hyperpolarizabilities have not been reported previously for most of these atoms. Our recommended values of the mean dipole polarizability (in the order Al-Ar) are alpha/e(2)a(0) (2)E(h) (-1)=57.74, 37.17, 24.93, 19.37, 14.57, and 11.085 with an error estimate of +/-0.5%. The recommended values of the mean second dipole hyperpolarizability (in the order Al-Ar) are gamma/e(4)a(0) (4)E(h) (-3)=2.02 x 10(5), 4.31 x 10(4), 1.14 x 10(4), 6.51 x 10(3), 2.73 x 10(3), and 1.18 x 10(3) with an error estimate of +/-2%. Our recommended polarizability anisotropy values are Deltaalpha/e(2)a(0) (2)E(h) (-1)=-25.60, 8.41, -3.63, and 1.71 for Al, Si, S, and Cl respectively, with an error estimate of +/-1%. The recommended hyperpolarizability anisotropies are Deltagamma/e(4)a(0) (4)E(h) (-3)=-3.88 x 10(5), 4.16 x 10(4), -7.00 x 10(3), and 1.65 x 10(3) for Al, Si, S, and Cl, respectively, with an error estimate of +/-4%. (c) 2005 American Institute of Physics.

Numerical Analysis of Turbulent Separated Subsonic Diffuser Flows

DTIC Science & Technology

1977-02-01

the s u b l a y e r r eg ion when one a t t e m p t s to use a un i fo rm coord ina te s y s t e m to d e s c r i b e the p r o - f i l es ...s u m e d p ro f i l e in the v ic in i ty of s e p a r a t i o n is ques t ionable . C l e a r l y , an adequate solut ion r e q u i r e s...in an 8-dell conical diffuser. 7.15 m O ,o H l 01 O1 (O AEDC-TR-76-159 1 .0 u~ O k O 4~ eS r-4 a ~4 el 0 . 8 0 . 6 0 . 4

INFLUENCE OF DIETARY ARSENIC ON URINARY ARSENIC METABOLITE EXCRETION

EPA Science Inventory

Influence of Dietary Arsenic on Urinary Arsenic Metabolite Excretion

Cara L. Carty, M.S., Edward E. Hudgens, B.Sc., Rebecca L. Calderon, Ph.D., M.S.P.H., Richard Kwok, M.S.P.H., Epidemiology and Biomarkers Branch/HSD, NHEERL/US EPA; David J. Thomas, Ph.D., Pharmacokinetics...

Étude de la perméabilité de la barrière hémato-encéphalique par microdialyse après irradiation photonique monofractionnée chez le rat

NASA Astrophysics Data System (ADS)

Agin, A.; Martin, C.; Mauris, J.; Staali, F.; Diserbo, M.

1999-01-01

The effects of total-body irradiation on the permeability of rat striatal blood-brain barrier (BBB) to [ ^3H] aminoisobutyric acid (AIBA) and [ 14C] sucrose were investigated. Seven days, 6 weeks, 3 and 5 months after gamma exposure at the dose of 4.5 Gy, no modification of the permeability to both [ ^3H] AIBA and [ 14C] sucrose was observed. A transient “opening" of the BBB to [ 14C] sucrose was noticed about 28 hours following irradiation. The transport of [3H] AIBA through BBB was decreased between the 33^th and the 47^th post-radiation hour. Nous avons étudié, dans le striatum de rat, les effets d'une irradiation globale aiguë sur la perméabilité de la barrière hémato-encéphalique à l'acide [ ^3H] aminoisobutyrique et au [ 14C] saccharose. Sept jours, 6 semaines, 3 et 5 mois après exposition γ à la dose de 4,5 Gy, aucune altération de la perméabilité aux deux marqueurs n'a été observée. Une “ouverture" transitoire de la BHE au [ 14C] saccharose est notée vers la 28e heure suivant l'irradiation. Le transport du [ ^3H] aminoisobutyrate est diminué entre 33 et 47 heures après irradiation.

Effects of Fluid Load on Human Urine Characteristics Related to Workplace Drug testing

DTIC Science & Technology

2012-03-01

Human.subject.participation.was.approved. by.the.Institutional.Review.Boards.of.the.University.of. Oklahoma.Health. Sciences. Center. (OUHSC),.Okla- homa . City,. OK,. and. of...Ju st A fte r F lu id In ta ke (S am pl e 3) A t S to m ac h C le ar an ce (S am pl e 4) A t F irs t U rg e (S am pl e 5

Barriers to Breast Cancer Screening among Latinas in the U.S.-Mexico Border Region

DTIC Science & Technology

2011-05-01

la Salud : A breast and cervical... en in g E ve r ha d a m am m og ra m H ad a M am m og ra m w ith in th e la st 2 ye ar s H ad a m am m og ra m w ith in th e la st ye ar U na dj us...Cancer Society, Atlanta, GA 22. Fernandez ME, Gonzales A, Tortolero-Luna G et al (2009) Effectiveness of Cultivando la Salud : a breast and cervical

Simplified curve fits for the thermodynamic properties of equilibrium air

NASA Technical Reports Server (NTRS)

Srinivasan, S.; Tannehill, J. C.; Weilmuenster, K. J.

1986-01-01

New improved curve fits for the thermodynamic properties of equilibrium air were developed. The curve fits are for p = p(e,rho), a = a(e,rho), T = T(e,rho), s = s(e,rho), T = T(p,rho), h = h(p,rho), rho = rho(p,s), e = e(p,s) and a = a(p,s). These curve fits can be readily incorporated into new or existing Computational Fluid Dynamics (CFD) codes if real-gas effects are desired. The curve fits were constructed using Grabau-type transition functions to model the thermodynamic surfaces in a piecewise manner. The accuracies and continuity of these curve fits are substantially improved over those of previous curve fits appearing in NASA CR-2470. These improvements were due to the incorporation of a small number of additional terms in the approximating polynomials and careful choices of the transition functions. The ranges of validity of the new curve fits are temperatures up to 25,000 K and densities from 10 to the minus 7th to 100 amagats (rho/rho sub 0).

Automatic Real Time Ionogram Scaler with True Height Analysis - Artist

DTIC Science & Technology

1983-07-01

scaled. The corresponding autoscaled values were compared with the manual scaled h’F, h’F2, fminF, foE, foEs, h’E and hlEs. The ARTIST program...I ... , ·~ J .,\\; j~~·n! I:\\’~ .. IC HT:/\\L rritw!E I ONOGI\\AM SCALER ’:!"[’!’if T:\\!_1!: H~:IGHT ANALYSIS - ARTIST P...S. TYPE OF REPORT & PERiCO COVERED Scientific Report No. 7 AUTOMATIC REAL TIME IONOGRAM SCALER WITH TRUE HEIGHT ANALYSIS - ARTIST 6. PERFORMING O𔃾G

Evidence that the atypical 5-HT3 receptor ligand, [3H]-BRL46470, labels additional 5-HT3 binding sites compared to [3H]-granisetron.

PubMed Central

Steward, L. J.; Ge, J.; Bentley, K. R.; Barber, P. C.; Hope, A. G.; Lambert, J. J.; Peters, J. A.; Blackburn, T. P.; Barnes, N. M.

1995-01-01

1. The radioligand binding characteristics of the 3H-derivative of the novel 5-HT3 receptor antagonist BRL46470 were investigated and directly compared to the well characterized 5-HT3 receptor radioligand [3H]-granisetron, in tissue homogenates prepared from rat cerebral cortex/hippocampus, rat ileum, NG108-15 cells, HEK-5-HT3As cells and human putamen. 2. In rat cerebral cortex/hippocampus, rat ileum, NG108-15 cell and HEK-5-HT3As cell homogenates, [3H]-BRL46470 bound with high affinity (Kd (nM): 1.57 +/- 0.18, 2.49 +/- 0.30, 1.84 +/- 0.27, 3.46 +/- 0.36, respectively; mean +/- s.e. mean, n = 3-4) to an apparently homogeneous saturable population of sites (Bmax (fmol mg-1 protein): 102 +/- 16, 44 +/- 4, 968 +/- 32 and 2055 +/- 105, respectively; mean +/- s.e. mean, n = 3-4) but failed to display specific binding in human putamen homogenates. 3. In the same homogenates of rat cerebral cortex/hippocampus, rat ileum, NG108-15 cells, HEK-5-HT3As cells and human putamen as used for the [3H]-BRL46470 studies, [3H]-granisetron also bound with high affinity (Kd (nM): 1.55 +/- 0.61, 2.31 +/- 0.44, 1.89 +/- 0.36, 2.03 +/- 0.42 and 6.46 +/- 2.58 respectively; mean +/- s.e. mean, n = 3-4) to an apparently homogeneous saturable population of sites (Bmax (fmol mg-1 protein): 39 +/- 4, 20 +/- 2, 521 +/- 47, 870 +/- 69 and 18 +/- 2, respectively; mean +/- s.e. mean, n = 3-4).(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8528560

Descriptive Summaries for Program Elements of the Research, Development, Test and Evaluation, Army FY 2001.. Volume 1 Budget Activities 1, 2 and 3

DTIC Science & Technology

2000-02-01

HH N N N O...t-~C-~000\\0\\00’-H<N H Z H Z O u o w 3 I OH o _1 w Q O O 00 .9 tä 8 CO t/2 £ «PS U Kl O S ~ ^ H IT W "K "S r3 & HH ...5 JB du U S et .3-3 « iäS.S > V T3 O c9 CS _ _ u ö u W Sa ’S « K ’C __ o. g 33 2 u a § « 5 »* e o S o s a

Status and Future of the Naval R&D Establishment

DTIC Science & Technology

2010-09-23

Market mostly here C u w e s t c o s t Global Allies Quadrant...Becoming more important and threatening L o w Free Market • Requires new mechanisms to handle 17 Framework for Assessment Implications S li Bupp er ase...t c o s t B a s e Corner: • Use sparingly Other US military US H i g u s t o m e r B • Prioritize rigorously Government US Market C u

NRL Plasma Formulary

DTIC Science & Technology

2007-01-01

1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law , no...β/α3 (h̄c)−1 Resistance 4πǫ0/α (ǫ0/µ0) 1/2 Time 1 c Velocity α c−1 18 MAXWELL’S EQUATIONS Name or Description SI Gaussian Faraday’s law ∇ × E = −∂B...t ∇ × E = − 1 c ∂B ∂t Ampere’s law ∇ × H = ∂D ∂t + J ∇ × H = 1 c ∂D ∂t + 4π c J Poisson equation ∇ · D = ρ ∇ · D = 4πρ [Absence of magnetic ∇ · B = 0

NRL: Plasma Formulary

DTIC Science & Technology

2004-12-01

Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law , no person...Pressure β/α3 (h̄c)−1 Resistance 4π0/α (0/µ0) 1/2 Time 1 c Velocity α c−1 19 MAXWELL’S EQUATIONS Name or Description SI Gaussian Faraday’s law ∇ × E = −∂B...t ∇ × E = − 1 c ∂B ∂t Ampere’s law ∇ × H = ∂D ∂t + J ∇ × H = 1 c ∂D ∂t + 4π c J Poisson equation ∇ · D = ρ ∇ · D = 4πρ [Absence of magnetic ∇ · B = 0

Light Extinction in a Dispersion of Small Nematic Droplets

DTIC Science & Technology

1988-07-13

OCAjANZAON REPORT NYBER(S) S MONITORING ORCANiZATiON REPORT NuMBLA(S3 Technical Report No. 9 G & INAME OF 9ERFORMING ORGANIZATION j6o OFFICE SYVMBOL...i~ O S (A T #I4 W ou roi l l v e of n ec essiy It’d d iitly by blOC N Aw mvia rj h c The light transmission properties of materials in whc submicron...E > and doj/dQ for the differential cross section ofj t h droplet. We use k s for k-k’. We have taken into account that there is no correlation

Cumulative Search-Evasion Games (CSEGs)

DTIC Science & Technology

1989-03-01

EVASI ON GAMES ( CSEGs ) . PERSONAL A UTHOR(S) Ea gl e , James N. ’ and Was hb urn , Alan R. a. TYPE OF REPO RT 113b T ME COVERED 114 DATE O F REPORT...Cumulative search - eva s ion games ( CSEGs) are t wo- pe r son ze r o- s um search- evasion games whe re p l ay proceeds t h r o ughout some speci fied pe...t he p ositions of the two players at time t’ t h e n the game ’ s p ayoff i s the sum over t from 1 to T of A( X ,Y ,t) . Additionally, all paths

Enhanced Androgen Signaling with Androgen Receptor Overexpression in the Osteoblast Lineage Controls Skeletal Turnover, Matrix Quality and Bone Architecture

DTIC Science & Technology

2008-12-01

Hounsfield units (HU) to mineral values (mg/cc of HA) through the use of...Ph.D. Russell Turner 5e. TASK NUMBER E-Mail: wirenk@ohsu.edu 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8...gn al in g IL -6 S ig n al in g H ep at ic Fi b ro si s/ H ep at ic … IL -1 0 S ig n al in g V D R /R X R A ct iv at io n P PA R S ig n al

Evaluation of aerated steam treatment of alfalfa and mung bean seeds to eliminate high levels of Escherichia coli O157:H7 and O178:H12, Salmonella enterica, and Listeria monocytogenes.

PubMed

Studer, Patrick; Heller, Werner E; Hummerjohann, Jörg; Drissner, David

2013-08-01

Sprouts contaminated with human pathogens are able to cause food-borne diseases due to the favorable growth conditions for bacteria during germination and because of minimal processing steps prior to consumption. We have investigated the potential of hot humid air, i.e., aerated steam, to treat alfalfa and mung bean seeds which have been artificially contaminated with Escherichia coli O157:H7, Salmonella enterica subsp. enterica serovar Weltevreden, and Listeria monocytogenes Scott A. In addition, a recently collected E. coli O178:H12 isolate, characterized by a reduced heat sensitivity, was exposed to the treatment described. Populations of E. coli O157:H7 and S. enterica on alfalfa and mung bean seeds could be completely eliminated by a 300-s treatment with steam at 70 ± 1°C as revealed by enrichment studies. L. monocytogenes and E. coli O178:H12 could not be completely eliminated from artificially inoculated seeds. However, bacterial populations were reduced by more than 5 log CFU/g on alfalfa and by more than 4 log CFU/g on mung bean seeds. The germination rate of mung beans was not affected by the 300-s treatment compared to the germination rate of untreated seeds whereas that of alfalfa seeds was significantly lower by 11.9%. This chemical-free method is an effective alternative to the 20,000-ppm hypochlorite treatment presently recommended by the U.S. Food and Drug Administration (FDA).

Evaluation of Aerated Steam Treatment of Alfalfa and Mung Bean Seeds To Eliminate High Levels of Escherichia coli O157:H7 and O178:H12, Salmonella enterica, and Listeria monocytogenes

PubMed Central

Studer, Patrick; Heller, Werner E.; Hummerjohann, Jörg

2013-01-01

Sprouts contaminated with human pathogens are able to cause food-borne diseases due to the favorable growth conditions for bacteria during germination and because of minimal processing steps prior to consumption. We have investigated the potential of hot humid air, i.e., aerated steam, to treat alfalfa and mung bean seeds which have been artificially contaminated with Escherichia coli O157:H7, Salmonella enterica subsp. enterica serovar Weltevreden, and Listeria monocytogenes Scott A. In addition, a recently collected E. coli O178:H12 isolate, characterized by a reduced heat sensitivity, was exposed to the treatment described. Populations of E. coli O157:H7 and S. enterica on alfalfa and mung bean seeds could be completely eliminated by a 300-s treatment with steam at 70 ± 1°C as revealed by enrichment studies. L. monocytogenes and E. coli O178:H12 could not be completely eliminated from artificially inoculated seeds. However, bacterial populations were reduced by more than 5 log CFU/g on alfalfa and by more than 4 log CFU/g on mung bean seeds. The germination rate of mung beans was not affected by the 300-s treatment compared to the germination rate of untreated seeds whereas that of alfalfa seeds was significantly lower by 11.9%. This chemical-free method is an effective alternative to the 20,000-ppm hypochlorite treatment presently recommended by the U.S. Food and Drug Administration (FDA). PMID:23709507

Pre-treatment with dexamethasone attenuates experimental ventilator-induced lung injury.

PubMed

Reis, Fernando Fonseca Dos; Reboredo, Maycon de Moura; Lucinda, Leda Marília Fonseca; Bianchi, Aydra Mendes Almeida; Rabelo, Maria Aparecida Esteves; Fonseca, Lídia Maria Carneiro da; Oliveira, Júlio César Abreu de; Pinheiro, Bruno Valle

2016-01-01

To evaluate the effects that administering dexamethasone before the induction of ventilator-induced lung injury (VILI) has on the temporal evolution of that injury. Wistar rats were allocated to one of three groups: pre-VILI administration of dexamethasone (dexamethasone group); pre-VILI administration of saline (control group); or ventilation only (sham group). The VILI was induced by ventilation at a high tidal volume. Animals in the dexamethasone and control groups were euthanized at 0, 4, 24, and 168 h after VILI induction. We analyzed arterial blood gases, lung edema, cell counts (total and differential) in the BAL fluid, and lung histology. At 0, 4, and 24 h after VILI induction, acute lung injury (ALI) scores were higher in the control group than in the sham group (p < 0.05). Administration of dexamethasone prior to VILI induction decreased the severity of the lung injury. At 4 h and 24 h after induction, the ALI score in the dexamethasone group was not significantly different from that observed for the sham group and was lower than that observed for the control group (p < 0.05). Neutrophil counts in BAL fluid were increased in the control and dexamethasone groups, peaking at 4 h after VILI induction (p < 0.05). However, the neutrophil counts were lower in the dexamethasone group than in the control group at 4 h and 24 h after induction (p < 0.05). Pre-treatment with dexamethasone also prevented the post-induction oxygenation impairment seen in the control group. Administration of dexamethasone prior to VILI induction attenuates the effects of the injury in Wistar rats. The molecular mechanisms of such injury and the possible clinical role of corticosteroids in VILI have yet to be elucidated. Avaliar os efeitos da administração de dexametasona antes da indução de lesão pulmonar induzida por ventilação mecânica (LPIVM) na evolução temporal dessa lesão. Ratos Wistar foram alocados em um dos três grupos: administração de dexametasona pré-LPIVM (grupo dexametasona); administração de salina pré-LPIVM (grupo controle); e somente ventilação (grupo sham). A LPIVM foi realizada por ventilação com volume corrente alto. Os animais dos grupos dexametasona e controle foram sacrificados em 0, 4, 24 e 168 h após LPIVM. Analisamos gasometria arterial, edema pulmonar, contagens de células (totais e diferenciais) no lavado broncoalveolar e histologia de tecido pulmonar. Em 0, 4 e 24 h após LPIVM, os escores de lesão pulmonar aguda (LPA) foram maiores no grupo controle que no grupo sham (p < 0,05). A administração de dexametasona antes da LPIVM reduziu a gravidade da lesão pulmonar. Em 4 e 24 h após a indução, o escore de LPA no grupo dexametasona não foi significativamente diferente daquele observado no grupo sham e foi menor que o observado no grupo controle (p < 0,05). As contagens de neutrófilos no lavado broncoalveolar estavam aumentadas nos grupos controle e dexametasona, com pico em 4 h após LPIVM (p < 0,05). Entretanto, as contagens de neutrófilos foram menores no grupo dexametasona que no grupo controle em 4 e 24 h após LPIVM (p < 0,05). O pré-tratamento com dexametasona também impediu o comprometimento da oxigenação após a indução visto no grupo controle. A administração de dexametasona antes de LPIVM atenua os efeitos da lesão em ratos Wistar. Os mecanismos moleculares dessa lesão e o possível papel clínico dos corticosteroides na LPIVM ainda precisam ser elucidados.

U.S. EPA, Pesticide Product Label, T-CHLOR, 02/21/1990

EPA Pesticide Factsheets

2011-04-21

... t, tI'.;r:;";~I, SII";' ;; cf ttu ;:;r;::IlIn 'Itt 10 s.llor.s,' ,,;tH t; ,rO,'I'" ,;;r;lll.jtE1J t:: ,;a "iili!:lt CtlOrlJ;1 II wtiS:;:. ... h;:) ,n~ rlr.Sf 5,U,:fCj Ir~I~'lr.t .Itt ;::."1' .,', far .u, ...

Liquid Water, the ``Most Complex'' Liquid: New Results in Bulk, Nanoconfined, and Biological Environments

NASA Astrophysics Data System (ADS)

Stanley, H. Eugene

2010-03-01

We will introduce some of the 63 anomalies of the most complex of liquids, water. We will demonstrate some recent progress in understanding these anomalies by combining information provided by recent experiments and simulations on water in bulk, nanoconfined, and biological environments. We will interpret evidence from recent experiments designed to test the hypothesis that liquid water may display ``polymorphism'' in that it can exist in two different phases---and discuss recent work on water's transport anomalies [1] as well as the unusual behavior of water in biological environments [2]. Finally, we will discuss how the general concept of liquid polymorphism [3] is proving useful in understanding anomalies in other liquids, such as silicon, silica, and carbon, as well as metallic glasses, which have in common that they are characterized by two characteristic length scales in their interactions. This work was supported by NSF Chemistry Division, and carried out in collaboration with a number of colleagues, chief among whom are C. A. Angell, M. C. Barbosa, M. C. Bellissent, L. Bosio, F. Bruni, S. V. Buldyrev, M. Canpolat, S. -H. Chen, P. G. Debenedetti, U. Essmann,G. Franzese, A. Geiger, N. Giovambattista, S. Han, P. Kumar, E. La Nave,G. Malescio, F. Mallamace, M. G. Mazza, O. Mishima, P. Netz, P. H. Poole, P. J. Rossky, R. Sadr,S. Sastry, A. Scala, F. Sciortino, A. Skibinsky, F. W. Starr, K. C. Stokely J. Teixeira, L. Xu, and Z. Yan.[4pt] [1] L. Xu, F. Mallamace, Z. Yan, F. W. Starr, S. V. Buldyrev, and H. E. Stanley, ``Appearance of a Fractional Stokes-Einstein Relation in Water and a Structural Interpretation of Its Onset,'' Nature Physics 5, 565--569 (2009). [0pt] [2] P. Kumar, Z. Yan, L. Xu, M. G. Mazza, S. V. Buldyrev, S. -H. Chen. S. Sastry, and H. E. Stanley, ``Glass Transition in Biomolecules and the Liquid-Liquid Critical Point of Water,'' Phys. Rev. Lett. 97, 177802 (2006). [0pt] [3] H. E. Stanley, ed. , Liquid Polymorphism [Advances in Chemical Physics], series edited by S. A. Rice (Wiley, New York, 2010).

Effect of High-Frequency Oscillations on Cough Peak Flows Generated by Mechanical In-Exsufflation in Medically Stable Subjects With Amyotrophic Lateral Sclerosis.

PubMed

Sancho, Jesús; Bures, Enric; de La Asunción, Saray; Servera, Emilio

2016-08-01

Mechanically assisted coughing with mechanical in-exsufflation (MI-E) is recommended for noninvasive management of respiratory secretions in amyotrophic lateral sclerosis (ALS). To improve the effectiveness of the technique, a new device combining MI-E with high-frequency oscillations (HFO) has been developed. This work aimed to assess the effect of HFO on the cough peak flow generated by MI-E in medically stable subjects with ALS. This was a prospective study that included subjects with ALS in a medically stable condition. Cough peak flow generated by MI-E was measured in 4 situations: without HFO, with HFO during insufflation, with HFO during exsufflation, and with HFO in both cycles. The parameters used were: insufflation pressure of +40 cm H2O, exsufflation pressure of -40 cm H2O, insufflation time 2 s, exsufflation time 3 s, amplitude of oscillations 10 cm H2O, and frequency of oscillations 15 Hz. Forty-seven subjects with ALS were included: 66% males, 68.2 ± 9.2 y, 40% with bulbar onset, FVC = 1.7 ± 1.1 L, percent-of-predicted FVC = 54.4 ± 26.6%, cough peak flow = 3.8 ± 2.2 L/s, PImax = -39.4 ± 26.4 cm H2O, revised ALS scale = 28.5 ± 9.3, Norris bulbar subscore = 26.1 ± 10.4. No statistical differences were found in cough peak flow generated by MI-E in the 4 situations (without HFO = 4.0 ± 1.2 L/s, with insufflation HFO = 3.9 ± 1.2 L/s, with exsufflation HFO = 4.1 ± 1.2 L/s, with in-exsufflation HFO = 3.9 ± 1.1 L/s). The addition of HFO to mechanically assisted coughing with MI-E does not have an effect on the cough peak flow of medically stable subjects with ALS. Copyright © 2016 by Daedalus Enterprises.

The impact of H2S emissions on future geothermal power generation - The Geysers region, California

NASA Technical Reports Server (NTRS)

Leibowitz, L. P.

1977-01-01

The future potential for geothermal power generation in the Geysers region of California is as much as 10 times the current 502 MW(e) capacity. However, environmental factors such as H2S emissions and institutional considerations may play the primary role in determining the rate and ultimate level of development. In this paper a scenario of future geothermal generation capacity and H2S emissions in the Geysers region is presented. Problem areas associated with H2S emissions, H2S abatement processes, plant operations, and government agency resources are described. The impact of H2S emissions on future development and the views of effected organizations are discussed. Potential actions needed to remove these constraints are summarized.

Hydride Conformers of the Nitrogenase FeMo-cofactor Two-Electron Reduced State E2(2H), Assigned Using Cryogenic Intra Electron Paramagnetic Resonance Cavity Photolysis.

PubMed

Lukoyanov, Dmitriy A; Khadka, Nimesh; Yang, Zhi-Yong; Dean, Dennis R; Seefeldt, Lance C; Hoffman, Brian M

2018-03-24

Early studies in which nitrogenase was freeze-trapped during enzymatic turnover revealed the presence of high-spin ( S = 3 / 2 ) electron paramagnetic resonance (EPR) signals from the active-site FeMo-cofactor (FeMo-co) in electron-reduced intermediates of the MoFe protein. Historically denoted as 1b and 1c, each of the signals is describable as a fictitious spin system, S' = 1 / 2 , with anisotropic g' tensor, 1b with g' = [4.21, 3.76, ?] and 1c with g' = [4.69, ∼3.20, ?]. A clear discrepancy between the magnetic properties of 1b and 1c and the kinetic analysis of their appearance during pre-steady-state turnover left their identities in doubt, however. We subsequently associated 1b with the state having accumulated 2[e - /H + ], denoted as E 2 (2H), and suggested that the reducing equivalents are stored on the catalytic FeMo-co cluster as an iron hydride, likely an [Fe-H-Fe] hydride bridge. Intra-EPR cavity photolysis (450 nm; temperature-independent from 4 to 12 K) of the E 2 (2H)/1b state now corroborates the identification of this state as storing two reducing equivalents as a hydride. Photolysis converts E 2 (2H)/1b to a state with the same EPR spectrum, and thus the same cofactor structure as pre-steady-state turnover 1c, but with a different active-site environment. Upon annealing of the photogenerated state at temperature T = 145 K, it relaxes back to E 2 (2H)/1b. This implies that the 1c signal comes from an E 2 (2H) hydride isomer of E 2 (2H)/1b that stores its two reducing equivalents either as a hydride bridge between a different pair of iron atoms or an Fe-H terminal hydride.

Structure and Dynamics of Cu3Au(001) Studied by Elastic and Inelastic Helium Atom Scattering

DTIC Science & Technology

1990-01-01

longitudinal] decouple from the shear horizontal (SH) modes. Selection rules dictate that our experiment was sensitive only to sagittal modes...Hoffmann, E. Preu3, R. Franchy , H. lbach, Y. Chen, M. L. Xu, and S Y. Tong, preprint. 4. A. i. Taub, and R. L. Fleisher, Science 243, 616 (1989).: B. H. Kear... Franchy , and H. Ibach, Z. Phys. B-Condensed Matter 65, 71 (1986). 19. E. D. Hallman, Can. J. Phys. 52, 2235 (1974). 20. E. C. Svensson, E. D. Hallman

Compensating for Language Deficits in Amnesia I: H.M.'s Spared Retrieval Categories.

PubMed

MacKay, Donald G; Johnson, Laura W; Fazel, Vedad; James, Lori E

2013-03-14

Three studies examined amnesic H.M.'s use of words, phrases, and propositions on the Test of Language Competence (TLC). In Study 1, H.M. used 19 lexical categories (e.g., common nouns, verbs) and one syntactic category (noun phrases) with the same relative frequency as memory-normal controls, he used no lexical or syntactic category with less-than-normal frequency, and he used proper names (e.g., Melanie) and coordinative conjunctions (e.g., and) with reliably greater-than-normal frequency. In Study 2, H.M. overused proper names relative to controls when answering episodic memory questions about childhood experiences in speech and writing, replicating and extending Study 1 results for proper names. Based on detailed analyses of the use (and misuse) of coordinating conjunctions on the TLC, Study 3 developed a syntax-level "compensation hypothesis" for explaining why H.M. overused coordinating conjunctions relative to controls in Study 1. Present results suggested that (a) frontal mechanisms for retrieving word-, phrase-, and propositional-categories are intact in H.M., unlike in category-specific aphasia, (b) using his intact retrieval mechanisms, H.M. has developed a never-previously-observed proposition-level free association strategy to compensate for the hippocampal region damage that has impaired his mechanisms for encoding novel linguistic structures, and (c) H.M.'s overuse of proper names warrants further research.

Compensating for Language Deficits in Amnesia I: H.M.’s Spared Retrieval Categories

PubMed Central

MacKay, Donald G.; Johnson, Laura W.; Fazel, Vedad; James, Lori E.

2013-01-01

Three studies examined amnesic H.M.’s use of words, phrases, and propositions on the Test of Language Competence (TLC). In Study 1, H.M. used 19 lexical categories (e.g., common nouns, verbs) and one syntactic category (noun phrases) with the same relative frequency as memory-normal controls, he used no lexical or syntactic category with less-than-normal frequency, and he used proper names (e.g., Melanie) and coordinative conjunctions (e.g., and) with reliably greater-than-normal frequency. In Study 2, H.M. overused proper names relative to controls when answering episodic memory questions about childhood experiences in speech and writing, replicating and extending Study 1 results for proper names. Based on detailed analyses of the use (and misuse) of coordinating conjunctions on the TLC, Study 3 developed a syntax-level “compensation hypothesis” for explaining why H.M. overused coordinating conjunctions relative to controls in Study 1. Present results suggested that (a) frontal mechanisms for retrieving word-, phrase-, and propositional-categories are intact in H.M., unlike in category-specific aphasia, (b) using his intact retrieval mechanisms, H.M. has developed a never-previously-observed proposition-level free association strategy to compensate for the hippocampal region damage that has impaired his mechanisms for encoding novel linguistic structures, and (c) H.M.’s overuse of proper names warrants further research. PMID:24961315

Boron Doped Nanocrystalline Film with Improved Work Function as a Buffer Layer in Thin Film Silicon Solar Cells.

PubMed

Park, Jinjoo; Shin, Chonghoon; Park, Hyeongsik; Jung, Junhee; Lee, Youn-Jung; Bong, Sungjae; Dao, Vinh Ai; Balaji, Nagarajan; Yi, Junsin

2015-03-01

We investigated thin film silicon solar cells with boron doped hydrogenated nanocrystalline silicon/ hydrogenated amorphous silicon oxide [p-type nc-Si:H/a-SiOx:H] layer. First, we researched the bandgap engineering of diborane (B2H6) doped wide bandgap hydrogenated nanocryslline silicon (p-type nc-Si:H) films, which have excellent electrical properties of high dark conductivity, and low activation energy. The films prepared with lower doping ratio and higher hydrogen dilution ratio had higher optical gap (Eg), with higher dark conductivity (σ(d)), and lower activation energy (Ea). We controlled Eg from 2.10 eV to 1.75 eV, with σ(d) from 1.1 S/cm to 7.59 x 10(-3) S/cm, and Ea from 0.040 eV to 0.128 eV. Next, we focused on the fabrication of thin film silicon solar cells. By inserting p-type nc-Si:H film into the thin film silicon solar cells, we achieved a remarkable increase in the built-in potential from 0.803 eV to 0.901 eV. By forming p-type nc-Si:H film between SnO2:F/ZnO:Al (30 nm) and p-type a-SiOx:H layer, the solar cell properties of open circuit voltage (Voc), short circuit current density (Jsc), and efficiency (η) were improved by 3.7%, 9.2%, and 9.8%, respectively.

Jupiter

NASA Astrophysics Data System (ADS)

Bagenal, Fran; Dowling, Timothy E.; McKinnon, William B.

2007-03-01

Preface; 1. Introduction F. Bagenal, T. E. Dowling and W. B. McKinnon; 2. The origin of Jupiter J. I. Lunine, A. Corandini, D. Gautier, T. C. Owen and G. Wuchterl; 3. The interior of Jupiter T. Guillot, D. J. Stevenson, W. B. Hubbard and D. Saumon; 4. The composition of the atmosphere of Jupiter F. W. Taylor, S. K. Atreya, Th. Encrenaz, D. M. Hunten, P. G. J. Irwin and T. C. Owen; 5. Jovian clouds and haze R. A. West, K. H. Baines, A. J. Friedson, D. Banfield, B. Ragent and F. W. Taylor; 6. Dynamics of Jupiter's atmosphere A. P. Ingersoll, T. E. Dowling, P. J. Gierasch, G. S. Orton, P. L. Read, A. Sánchez-Lavega, A. P. Showman, A. A. Simon-Miller and A. R. Vasavada; 7. The stratosphere of Jupiter J. I. Moses, T. Fouchet, R. V. Yelle, A. J. Friedson, G. S. Orton, B. Bézard, P. Drossart, G. R. Gladstone, T. Kostiuk and T. A. Livengood; 8. Lessons from Shoemaker-Levy 9 about Jupiter and planetary impacts J. Harrington, I. de Pater, S. H. Brecht, D. Deming, V. Meadows, K. Zahnle and P. D. Nicholson; 9. Jupiter's thermosphere and ionosphere R. V. Yelle and S. Miller; 10. Jovian dust: streams, clouds and rings H. Krüger, M. Horányi, A. V. Krivov and A. L. Graps; 11. Jupiter's ring-moon system J. A. Burns, D. P. Simonelli, M. R. Showalter, D. P. Hamilton, C. C. Porco, H. Throop and L. W. Esposito; 12. Jupiter's outer satellites and trojans D. C. Jewitt, S. Sheppard and C. Porco; 13. Interior composition, structure and dynamics of the Galilean satellites G. Schubert, J. D. Anderson, T. Spohn and W. B. McKinnon; 14. The lithosphere and surface of Io A. S. McEwen, L. P. Keszthelyi, R. Lopes, P. M. Schenk and J. R. Spencer; 15. Geology of Europa R. Greeley, C. F. Chyba, J. W. Head III, T. B. McCord, W. B. McKinnon, R. T. Pappalardo and P. Figueredo; 16. Geology of Ganymede R. T. Pappalardo, G. C. Collins, J. W. Head III, P. Helfenstein, T. B. McCord, J. M. Moore, L. M. Procktor, P. M. Shenk and J. R. Spencer; 17. Callisto J. M. Moore, C. R. Chapman. E. B. Bierhaus, R. Greeley, F. C. Chuang, J. Klemaszewski, R. N. Clark, J. B. Dalton, C. A. Hibbitts, P. M. Schenk, J. R. Spencer and R. Wagner; 18. Ages and interiors: the cratering record of the Galilean satellites P. M. Schenk, C. R. Chapman, K. Zahnle and J. M. Moore; 19. Satellite atmospheres M. A. McGrath, E. Lellouch, D. F. Strobel, P. D. Feldman and R. E. Johnson; 20. Radiation effects on the surfaces of the Galilean satellites R. E. Johnson, R. W. Carlson, J. F. Cooper, C. Paranicas, M. H. Moore and M. C. Wong; 21. Magnetospheric interactions with satellites M. G. Kivelson, F. Bagenal, W. S. Kurth, F. M. Neubauer, C. Paranicas and J. Saur; 22. Plasma interactions of Io with its plasma torus J. Saur, F. M. Neubauer, J. E. P. Connerney, P. Zarka and M. G. Kivelson; 23. The Io neutral clouds and plasma torus N. Thomas, F. Bagenal, T. W. Hill and J. K. Wilson; 24. The configuration of Jupiter's magnetosphere K. K. Khurana, M. G. Kivelson, V. M. Vasyliunas, N. Krupp, J. Woch, A. Lagg, B. H. Mauk and W. S. Kurth; 25. Dynamics of the Jovian magnetosphere N. Krupp, V. M. Vasyliunas, J. Woch, A. Lagg, K. K. Khurana, M. G. Kivelson, B. H. Mauk, E. C. Roelof, D. J. Williams, S. M. Krimigis, W. S. Kurth, L. A. Frank and W. R. Paterson; 26. Jupiter's Aurora J. T. Clarke, D. Grodent, S. W. H. Cowley, E. J. Bunce, P. Zarka, J. E. P. Connerney and T. Satoh; 27. Jupiter's inner radiation belts S. J. Bolton, R. M. Thorne, S. Bourdarie, I. de Pater and B. Mauk; Appendix 1. Maps and spectra of Jupiter and the Galilean satellites J. R. Spencer, R. W. Carlson, T. L. Becker and J. S. Blue; Appendix 2. Planetary parameters J. W. Weiss; Index.

Chemically Resolved Interface Structure of Epitaxial Graphene on SiC(0001)

DTIC Science & Technology

2013-11-19

Phys. Rev. B 76, 235416 (2007). [22] W . Chen, H. Xu, L. Liu, X.Y. Gao, D. C. Qi, G.W. Peng, S. C. Tan, Y. P. Feng, K. P. Loh, and A. T. S. Wee, Surf...J. Hass, J. E. Millan-Otoya, P. N. First, and E.H. Conrad, Phys. Rev. B 78, 205424 (2008). [27] J. Borysiuk, R. Bozek, W . Strupinski, A. Wysmolek, K...to the X-ray polarization FIG. S1: Experimental geometries for both (a) conventional XPS (α ~78°) used for survey scans and ( b ) highly surface

Class A Sodalites: Silver, Sodium, Halosodalites

DTIC Science & Technology

1992-05-15

always possessed Ag 5s and Ag 5 p characteristics while the HOMO orbitals were mixtures of mainly X np (X n = Cl 3, Br 4,15) and Ag 4d orbitals with some...Small Particles, J. Wiley & Sans: N . Y., 1983, p . 132. 1012. Calzaferri, 0.; Forss, L; Hugentobler, T.; Kamber, L ICONC and INPUTC, Fortran software for...nw q U . * e c ,s , aD a m ,,m", h u s ( a in m n ntfu hIh,, - , ,e - - - - . - .. - . ; -.T -?- -/ ~ ~ ~~ w Wtmuf.,cua sltl ro r l fut"O. to w

Innovative Methods for Engine Health Monitoring

DTIC Science & Technology

2006-11-30

ELEMENT NUMBER 6. AUTHOR(S) 6d. PROJECT NUMBER C. L. Philip Chen, Z. Pantic-Tanner, H. Millwater , S. Hudak, Y. Huang, P. Cotae, D. Tanner, E. John, K. Chan...Philip Chen’, Z. Pantic-Tanner 2, H. Millwater 3, S. Hudak 4, Y. Huang5, P. Cotae6, D. Tanner 7, E. Johns, K.Chan9, X. Wang𔃺 1 - Professor and Chair... Millwater , R.C. McClung, M.P. Enright, "A new tool for design and certification of aircraft turbine rotors," Journal of Engineering for Gas Turbines

E A R T H - S C I E N C E S L I N K S

Science.gov Websites

TSUNAMI! NOAA TSUNAMI Project TSUNAMI Web Site TSUNAMIS in the circum-Pacific Ring of Fire The TSUNAMI DINOSAURS PLATE TECTONICS The Dinosaur Web Pages DINOSAURIA ON-LINE Fossils & Dinosaurs Earth Through opportunities in the earth sciences Geologic Time USGS Learning Web Geoscience Information Center National

Advances in Explosively Formed Fuse Opening Switches

DTIC Science & Technology

1987-06-01

ADVANCES IN EXPLOSIVELY FORMED FUSE OPENING SWITCHES* J. H. Goforth, R. S. Caird, A. E. Greene, I. R. Lindemuth, S. P. Marsh, H. Oona, and R. E...conductor into a series of thin sections. Augmented by an undetermined amount of heating due to the extrusion process, Joule heating in the thin...with initial field fed directly into the generator by a capacitor bank. As described in Ref. 2, these tests demonstrated that the switch would

Flux Pinning in YBa2Cu3O7-delta Thin Film Samples Linked to Stacking Fault Density (Postprint)

DTIC Science & Technology

2008-10-01

Driscoll, S. R. Foltyn, Q. X. Jia, H. Wang, A. Serquis, B. Maiorov, L. Civale, Y. Lin, M. E. Hawley , M. P. Maley, and D. E. Peter- son, Appl. Phys. Lett. 84...Civale, B. Maiorov, A. Serquis, J. O. Willis , J. Y. Coulter, H. Wang, Q. X. Jia, P. N. Arendt, J. L. MacManus-Driscoll, M. P. Maley, and S. R. Foltyn, Appl

U.S. EPA, Pesticide Product Label, CARBARYL 50-W INSECTICIDE, 11/16/1972

EPA Pesticide Factsheets

2011-04-21

... lJ\\.· l til '1 IU'\\lIl(t~ 1", (II'" ".H'hPIIll ('Off1 IIJotW',rm .Idulh E.tHUp··,11l CoIn ho, .. r faH .lfrnyworm, 1" . .1 bo·.·t't·' J.lp,"lt· ... ... It',j b ... eU.' I, ~ .'Ider htJg ...

A Proteomic Analysis Reveals Differential Regulation of the σS-Dependent yciGFE(katN) Locus by YncC and H-NS in Salmonella and Escherichia coli K-12

PubMed Central

Beraud, Mélanie; Kolb, Annie; Monteil, Véronique; D'Alayer, Jacques; Norel, Françoise

2010-01-01

The stationary phase sigma factor σS (RpoS) controls a regulon required for general stress resistance of the closely related enterobacteria Salmonella and Escherichia coli. The σS-dependent yncC gene encodes a putative DNA binding regulatory protein. Application of the surface-enhanced laser desorption/ionization-time of flight (SELDI-TOF) ProteinChip technology for proteome profiling of wild-type and mutant strains of Salmonella enterica serovar Typhimurium revealed potential protein targets for YncC regulation, which were identified by mass spectrometry, and subsequently validated. These proteins are encoded by the σS-dependent operon yciGFEkatN and regulation of their expression by YncC operates at the transcriptional level, as demonstrated by gene fusion analyses and by in vitro transcription and DNase I footprinting experiments with purified YncC. The yciGFE genes are present (without katN) in E. coli K-12 but are poorly expressed, compared with the situation in Salmonella. We report that the yciGFE(katN) locus is silenced by the histone-like protein H-NS in both species, but that σS efficiently relieves silencing in Salmonella but not in E. coli K-12. In Salmonella, YncC acts in concert with σS to activate transcription at the yciG promoter (pyciG). When overproduced, YncC also activated σS-dependent transcription at pyciG in E. coli K-12, but solely by countering the negative effect of H-NS. Our results indicate that differences between Salmonella and E. coli K-12, in the architecture of cis-acting regulatory sequences upstream of pyciG, contribute to the differential regulation of the yciGFE(katN) genes by H-NS and YncC in these two enterobacteria. In E. coli, this locus is subject to gene rearrangements and also likely to horizontal gene transfer, consistent with its repression by the xenogeneic silencer H-NS. PMID:20713450

Gestion de l’anémie des patients hémodialysés chroniques: cas du Service de Néphrologie et d’hémodialyse du CHU du Point G au Mali

PubMed Central

Tounkara, Alhadji Ahmadou; Coulibaly, Abdoul Mahama Sériba; Coulibaly, Nouhoun; Traoré, Békaye; Maïga, Mahamane Kalil

2017-01-01

Introduction L'anémie est une complication fréquente de l'IRC couramment retrouvée chez les patients hémodialysés chroniques. Chez ces derniers, la prise en charge est principalement basée sur l'administration d'érythropoïétine et la supplémentation en fer. Le but de ce travail était d'évaluer la prise en charge de l'anémie des hémodialysés chroniques dans le service de Néphrologie du CHU du Point G. Méthodes Il s'agissait d'une étude transversale réalisée dans ledit service du 1er au 31 Août 2016. Résultats Au total, 63 patients sur 174 participants avaient été retenus, 34 hommes et 29 femmes avec un sex-ratio à 1,17 en faveur des hommes. L'âge moyen des patients était de 48,79 ans ± 11,59, la durée moyenne en hémodialyse était de 3,77ans ± 2,6. La fréquence hospitalière de l'anémie chez nos dialysés était de 84,12%. La transfusion sanguine était retrouvée chez 92,1%, avec une moyenne annuelle de 5,81poches ± 5,91. La supplémentation martiale était notée dans 87,3% des cas. Les moyennes respectives de ferritine et de CST étaient de 1245 ng/ml ± 629,52 et 46,16%±19,12. L'administration occasionnelle d'EPO à des doses n'excédant pas les 4000UI était rapportée par 79,4% des patients. La principale difficulté pour l'utilisation de l' EPO était le coût (74,6%). L'infection au VHC touchait 60,1% des patients ayant réalisé le dit bilan. Conclusion La gestion de l'anémie des dialysés chroniques doit être intégrée dans un cadre politique nationale de la santé. PMID:28674560

Effect of Heating and Glycation on the Allergenicity of 2S Albumins (Ara h 2/6) from Peanut

PubMed Central

Skov, Per Stahl; Johnson, Phil E.; Rigby, Neil M.; Przybylski-Nicaise, Laetitia; Bernard, Hervé; Wal, Jean-Michel; Ballmer-Weber, Barbara; Zuidmeer-Jongejan, Laurian; Szépfalusi, Zsolt; Ruinemans-Koerts, Janneke; Jansen, Ad P. H.; Savelkoul, Huub F. J.; Wichers, Harry J.; Mackie, Alan R.; Mills, Clare E. N.; Adel-Patient, Karine

2011-01-01

Background Peanut allergy is one of the most common and severe food allergies, and processing is known to influence the allergenicity of peanut proteins. We aimed to establish the effect of heating and glycation on the IgE-binding properties and biological activity of 2S albumins (Ara h 2/6) from peanut. Methodology/Principal Findings Native Ara h 2/6 was purified from raw peanuts and heated in solution (15 min, 110°C) in the presence or absence of glucose. Ara h 2 and 6 were also purified from roasted peanut. Using PBMC and sera from peanut-allergic patients, the cellular proliferative potency and IgE reactivity (reverse EAST inhibition) and functionality (basophil degranulation capacity) of allergens were assessed. Heating Ara h 2/6 at 110°C resulted in extensive denaturation, hydrolysis and aggregation of the protein, whilst Ara h 2 and 6 isolated from roasted peanut retained its native conformation. Allergen stimulation of PBMC induced proliferation and Th2 cytokine secretion which was unaffected by thermal processing. Conversely, IgE reactivity and functionality of Ara h 2/6 was decreased by heating. Whilst heating-glycation further reduced the IgE binding capacity of the proteins, it moderated their loss of histamine releasing capacity. Ara h 2 and 6 purified from roasted peanut demonstrated the same IgE reactivity as unheated, native Ara h 2/6. Conclusions/Significance Although no effect of processing on T-cell reactivity was observed, heat induced denaturation reduced the IgE reactivity and subsequent functionality of Ara h 2/6. Conversely, Ara h 2 and 6 purified from roasted peanut retained the structure and IgE reactivity/functionality of the native protein which may explain the allergenic potency of this protein. Through detailed molecular study and allergenicity assessment approaches, this work then gives new insights into the effect of thermal processing on structure/allergenicity of peanut proteins. PMID:21901150

U.S. EPA, Pesticide Product Label, , 01/31/1985

EPA Pesticide Factsheets

2011-04-14

... tt o,.v,/I(.t"1I \\.oil '') e.;_.i_ I • .,,:1-, ')1 ,;.t~t(J ~;:".I,_ "';.~h .I~ :"'f' '.I!e- ~~. ? O$~I!!' ;. I:'::' ... Sm,l) I r' iy inc Lt'1 Sf'S H'''(helli «:luv,,1' :!lites Ch ... ...

Electron transfer of quinone self-assembled monolayers on a gold electrode.

PubMed

Nagata, Morio; Kondo, Masaharu; Suemori, Yoshiharu; Ochiai, Tsuyoshi; Dewa, Takehisa; Ohtsuka, Toshiaki; Nango, Mamoru

2008-06-15

Dialkyl disulfide-linked naphthoquinone, (NQ-Cn-S)2, and anthraquinone, (AQ-Cn-S)2, derivatives with different spacer alkyl chains (Cn: n=2, 6, 12) were synthesized and these quinone derivatives were self-assembled on a gold electrode. The formation of self-assembled monolayers (SAMs) of these derivatives on a gold electrode was confirmed by infrared reflection-absorption spectroscopy (IR-RAS). Electron transfer between the derivatives and the gold electrode was studied by cyclic voltammetry. On the cyclic voltammogram a reversible redox reaction between quinone (Q) and hydroquinone (QH2) was clearly observed under an aqueous condition. The formal potentials for NQ and AQ derivatives were -0.48 and -0.58 V, respectively, that did not depend on the spacer length. The oxidation and reduction peak currents were strongly dependent on the spacer alkyl chain length. The redox behavior of quinone derivatives depended on the pH condition of the buffer solution. The pH dependence was in agreement with a theoretical value of E 1/2 (mV)=E'-59pH for 2H+/2e(-) process in the pH range 3-11. In the range higher than pH 11, the value was estimated with E 1/2 (mV)=E'-30pH , which may correspond to H+/2e(-) process. The tunneling barrier coefficients (beta) for NQ and AQ SAMs were determined to be 0.12 and 0.73 per methylene group (CH2), respectively. Comparison of the structures and the alkyl chain length of quinones derivatives on these electron transfers on the electrode is made.

Medical Effects of Atomic Bombs. The Report of the Joint Commission for the Investigation of the Effects of the Atomic Bomb in Japan; Volume 5

DTIC Science & Technology

1951-04-19

t rea txents a r e shown on the back of the Porn (figure l b ) under i t e m 10, 63 If the pa t icn t dicd, t he dlzto, cause and autopsy...j.nconp1etely recorded, being copied from old records, Furthermore, cases l as t seen a wekk or two after t h e bombing, and d i v e a t t h a t...l a s t cd an ,z.vo;.agc of 16 -8 days .in C ~ S C S obsorvcd i n Hiroshima and 10,2 days i n Naps&i, appoar to be correl a%cd with .d ls Lance

[Asu(1,7)E-CT, an analog of eel calcitonin. A comparative study in man with reference to other synthetic calcitonins].

PubMed

Caniggia, A; Nuti, R; Vattimo, A; Galli, M; Turchetti, V; Franci, B; Martorelli, T; Righi, G

1983-04-28

(Asu) E-CT is a deaminodicarba-analog of the synthetic eel-calcitonin (E-CT) that shows specific activity and the potency reasonably high in comparison with that of the most potent natural hormone. The structure of its molecule indicates that the disulphide bond in calcitonins is not essential for the biological activity but only for the maintenance of the specific conformation by forming an intramolecular bridge. The instability of calcitonins should mainly be attributed to the presence of the disulfide bond and (Asu)E-CT proved to be more stable "in vitro" than native calcitonins. The more prolonged hypocalcemic effect of E-CT and its aminosuberic analog (Asu)E-CT has been accounted for to a greater stability of and persistence at the receptor site. (Asu) E-CT has been largely studied in Japan on experimental animals and successfully used in the treatment of hypercalcemia in man. On the contrary investigations on human administration of this analog are very scarce. The present paper reports studies carried out in normal subjects and Paget's disease patients to investigate the effects of (Asu)E-CT in man in comparison with the effects of synthetic human calcitonin (H-CT) and synthetic salmon calcitonin (S-CT). Two different experimental procedures have been used: 1) rapid intravenous injection of (Asu)E-CT (80 MRC. U.) or respectively of H-CT and S-CT (100 MRC. U.) in 15 subjects (7 normals and 8 with Paget's disease); 2) slow 7 days continuous subcutaneous infusion of similar daily amounts of (Asu)E-CT, H-CT and S-CT administered by a microjet pump device in 21 subjects (7 normals and 14 with Paget's disease). The intravenous administration of (Asu)E-CT induced a rapid and persistent decrease in total plasma calcium, ionized calcium and plasma phosphate that was more evident in Paget's disease patients than in normal subjects. No clearly cut differences have been observed with the hypocalcemic and hypophosphatemic effect of H-CT and S-CT administered intravenously; nevertheless the hypocalcemic effect proved to be more persistent in Paget's disease patients treated with (Asu)E-CT. After intravenous infusion of (Asu)E-CT the plasma level of cAMP rose more evidently in pagetic than in normal subjects but the rise was lower than in H-CT and S-CT treated subjects.(ABSTRACT TRUNCATED AT 400 WORDS)

Noninvasive Localization of Prostate Cancer via Diffusion Sensitive MRI

DTIC Science & Technology

2007-03-01

16: 196-200, 2002. 13. Chan, I., Wells, W., 3rd, Mulkern, R. V., Haker , S., Zhang, J., Zou, K. H., Maier, S. E., and Tempany, C. M. Detection of...for Magnetic Resonance in Medicine, 13: 269, 2005. 31. Haker , S. J., Szot Barnes, A., Maier, S. E., Tempany, C. M., and Mulkern, R. V. Diffusion...Resonance in Medicine, 13: 2126, 2005. 32. Roebuck, J. R., Haker , S. J., Tempany, C. M., Rybicki, F. J., Maier, S. E., and Mulkern, R. V. Diffusion

Installation Restoration Program. Phase 1. Records Search, Hazardous Materials Disposal Sites, Eglin AFB, Florida

DTIC Science & Technology

1981-10-01

Okaloosa Co. 3-12 Crestview South Quadrangle, Florida-Okaloosa Co. -13 Mossy ead Quadrangle, Florida-Walton Co 3-14 E-1 EGUN AFB 4,h aa V, WRAMATIO...I) Um AYPM hIN1DS SP * So". AM T 0 Tou A is a O I. h E-2 ES ENGINEERING -SCIENCE V%777-7NN7 .7-7 EGUN AFB 0.4 .m ... (1) WMg LAN DOSAMU *Y* CO u...r Oumm *p S(S Ann~ Il~~O 0*aAMa 2-3 ES ENGINEER ING - SCIENCE EGUN AFB %Tt MAR ESTHER * : . . - . - ~ - ~ r W R G H T L A N D F I L L 3 SITE 0296

EXEIS Expert Screening and Optimal Extraction/Injection Pumping Systems for Short-Term Plume Immobilization

DTIC Science & Technology

1990-05-01

TT) d head at observation well j which is down-gradient of the contamination source at the end of the modeling period TT, (L). h head at contaminant...period t, (L); =h 1 ,0 i,t h U = upper limit on head at pump i, (L); (h jTT) d = head at each observation well j which is down-gradient of...E) E D.i j k qt k 1 . . (30)f~q = r~~t ~ I I , j ,k qt-k+l.................(0 i=1 k=1 where: D . - ~ ~ [ft(Qo)A i ,kS dt + fs(Qo)P i j ,k’ dS

2009 Biometrics Conference

DTIC Science & Technology

2009-01-28

STATEMENT USNORTHCOM ti i t d d t H l d D f d an c pa es an con uc s ome an e ense an Civil Support operations within the assigned area of responsibility... operational goals and objectives of HSPD-24 and make our world a safer place to live and work. Promotional Partners: Increase your company or organization...INFORMATION Ir i tech, Inc. S A I C B o o z A l l e n H a m i l t o n Aware, Inc. H i t ach i A mer i c a , LT D Companies that will be displaying

A Comparison of Two Acoustic Parabolic Transmisssion Loss Models for Compatibility with the Wavenumber Technique in the Determination of Source Depth.

DTIC Science & Technology

1984-03-01

4 ~ L04 z 0 C) A L- L- - U)NN. 4 0 N 0QzP4L~ (iO m tn HL-4, "Ŕs~4 bn (/) L- U) 44C U )~ H W .WE- L C 04 Ql= H . L- HlA ~~~E- 0=000-~~0 0.N 4 ~U NOSmi...4*44* *4** *444 4* 4 Wz -u >* Pi -. ,: L 4 H 4 Q H~- --~ * H E - 0W 4 adI 0 0n :U -" 4 4% U 1 (n t F-4 1042 = *4 *- 44-, w Hl~w 4&4 *-- i* U E E- r 44

Study of Avalanche Discharge Lasers.

DTIC Science & Technology

1983-09-30

tic a com ponents ued fosr . o sern tio of X e1 .~i fluorescence an l se S o u r cs wi t as o e r i r s p e s u r e s a n d c r r e n t obseT...R. P . Akins and S. C. Lin, Appl. Phys. Lett. 28, 221 (1976). A 4. C. P . Wang, H. Mirels, D. G. Sutton, and S. N . Suchard, Appl. Phys. Lett. 28 , 326...intensity at the output coupling mirror, Ia , which deter- mines the laser oscillator output power PL P viz., I + n [ exp(2. 303D)+ Raexp(-Z. 33D) f , (9

Computer-Based Aids for Learning, Job Performance, and Decision-Making in Military Applications: Emergent Technology and Challenges

DTIC Science & Technology

2002-12-01

Educational Psychology (pp. 47–62). New York, NY: Macmillan. Neisser , U . (1967). Cognitive psychology. New York, NY: Appleton, Century, Crofts. Noja, G.P...J. D. Fletcher I N S T I T U T E F O R D E F E N S E A N A L Y S E S IDA Document D-2786 Log: H 02-002085 December 2002 Approved for public...material may be reproduced by or for the U.S. Government pursuant to the copyright license under the clause at DFARS 252.227-7013 (NOV 95). I N S T I T U T

Evaluation of a quantitative H2S MPN test for fecal microbes analysis of water using biochemical and molecular identification.

PubMed

McMahan, Lanakila; Grunden, Amy M; Devine, Anthony A; Sobsey, Mark D

2012-04-15

The sensitivity and specificity of the H(2)S test to detect fecal bacteria in water has been variable and uncertain in previous studies, partly due to its presence-absence results. Furthermore, in groundwater samples false-positive results have been reported, with H(2)S-positive samples containing no fecal coliforms or Escherichia coli. False-negative results also have been reported in other studies, with H(2)S-negative samples found to contain E. coli. Using biochemical and molecular methods and a novel quantitative test format, this research identified the types and numbers of microbial community members present in natural water samples, including fecal indicators and pathogens as well as other bacteria. Representative water sources tested in this study included cistern rainwater, a protected lake, and wells in agricultural and forest settings. Samples from quantitative H(2)S tests of water were further cultured for fecal bacteria by spread plating onto the selective media for detection and isolation of Aeromonas spp., E. coli, Clostridium spp., H(2)S-producers, and species of Salmonella and Shigella. Isolates were then tested for H(2)S production, and identified to the genus and species level using biochemical methods. Terminal Restriction Fragment Length Polymorphisms (TRFLP) was the molecular method employed to quantitatively characterize microbial community diversity. Overall, it was shown that water samples testing positive for H(2)S bacteria also had bacteria of likely fecal origin and waters containing fecal pathogens also were positive for H(2)S bacteria. Of the microorganisms isolated from natural water, greater than 70 percent were identified using TRFLP analysis to reveal a relatively stable group of organisms whose community composition differed with water source and over time. These results further document the validity of the H(2)S test for detecting and quantifying fecal contamination of water. Copyright © 2011 Elsevier Ltd. All rights reserved.

Enhancement of lysyl-tRNA synthetase activity in the Enterobacteriaceae

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hickey, E.W.; Hirshfield, I.

1987-05-01

Lysyl-tRNA synthetase (LRS) in E. coli is coded by two genes, one constitutive, and the other inducible; the latter is a cell stress protein. To determine if this system is wide spread in prokaryotes, the inducibility of LRS was first tested in eight members of the Enterobacteriaceae using cultural conditions known to induce the enzyme in E. coli K-12. Uninduced control cultures were grown to an O.D. of 0.2 at 580 nm in a supplemented minimal medium (SMM), pH 7.0 at 37/sup 0/C. Induction stimuli include: growth in SMM with 3mM Gly-L-Leu; growth in SMM as above, but with themore » initial pH adjusted to 5.0; or growth in Difco AC Broth to early stationary phase with a concomitant drop in the pH of the medium below 5.5. LRS activity was assayed in whole-cell sonic extracts by the aminoacylation of crude E. coli tRNA by /sup 14/C-lysine at pH 7.8 for three minutes. When E. aerogenes, K. pneumoniae, C. freundii, and S. typhimurium were grown in AC Broth, LRS activity was enhanced 2 to 4 fold. The enzyme is induced 2 to 4 fold in C. freundii and S. typhimurium upon growth at pH 5.0, whereas E. coli, K.; pneumoniae, and E. aerogenes show only a 1.5 fold induction. The peptide Gly-L-Leu enhanced LRS activity only in E. coli. LRS was not found to be inducible in S. marcescens, M. morganii, P. mirabilis, or P. vulgaris by any of the stimuli.« less

Fires. A Joint Publication for U.S. Artillery Professionals. July - August 2011

DTIC Science & Technology

2011-07-01

fundamentalism was diametrically opposed to the democratic capitalist system and the Western conception of freedom and liberalism. The religion of Islam...The process of dismantling and inactivating the F i n a l l y , w e w e r e s t a r t i n g t o s e e s i g n s o f a n o r g a n i z a t i o...with the number of hostile attacks that the system has intercepted. (Photo courtesy of Task Force C-RAM) A l l t h a t w e d o a s m i l i t a r y

H{sub 2} adsorption in Li-decorated porous graphene

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seenithurai, S.; Pandyan, R. Kodi; Kumar, S. Vinodh

Porous graphene (PG) has been decorated with Li atoms and subsequently studied the hydrogen (H{sub 2}) adsorption characteristics, by using Density Functional Theory (DFT)-based calculations. A 2×2 PG has been decorated with eight Li atoms. Upto four H{sub 2} molecules get adsorbed on each Li atom. The maximum H{sub 2} storage capacity that could be achieved in 2×2PG-8Li is 8.95 wt% which is higher than the U.S. DOE’s revised target for the on-board vehicles. The average H{sub 2} adsorption binding energy is 0.535 eV/H{sub 2}, which lies between 0.2-0.6 eV/H{sub 2} that is required for achieving adsorption and desorption atmore » near ambient conditions. Thus, Li-decorated PG could be a viable option for on-board automobile applications.« less

SK-Edge XAS And DFT Calculations on Square-Planar NiII-Thiolate Complexes: Effects of Active And Passive H-Bonding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dey, A.; Green, K.N.; Jenkins, R.M.

S K-edge XAS for a low-spin Ni{sup II}-thiolate complex shows a 0.2 eV shift to higher pre-edge energy but no change in Ni-S bond covalency upon H-bonding. This is different from the H-bonding effect we observed in high-spin Fe{sup III}-thiolate complexes where there is a significant decrease in Fe-S bond covalency but no change in energy due to H-bonding (Dey, A.; Okamura, T.-A.; Ueyama, N.; Hedman, B.; Hodgson, K. O.; Solomon, E. I. J. Am. Chem. Soc. 2005, 127, 12046-12053). These differences were analyzed using DFT calculations, and the results indicate that two different types of H-bonding interactions are possiblemore » in metal-thiolate systems. In the high-spin Fe{sup III}-thiolate case, the H-bonding involves a thiolate donor orbital which is also involved in bonding with the metal (active), while in the low-spin Ni{sup II}-thiolate, the orbital involved in H-bonding is nonbonding with respect to the M-S bonding (passive). The contributions of active and passive H-bonds to the reduction potential and Lewis acid properties of a metal center are evaluated.« less

Structural Analysis of the Dimerization Domain of the Human Estrogen Receptor and a Peptide Inhibitor of Dimerization

DTIC Science & Technology

1998-08-01

communication). Various hER fragments were expressed in Esherichia coli (E. coli ) as glutathione-S-transferace (GST) fusion proteins, separated by...Using an E. coli expression vector, we successfully overexpressed hER[253-341] as a fusion protein with an N-terminal poly-histidine tag (Figure 1A...of hER fused to GST were expressed in E. coli , and they were then separated on SDS PAGE, and then transferred to a blotting membrane. The membrane was

Role of Rad23 and Dsk2 in Nucleotide Excision Repair and Spindle Pole Body Duplication

DTIC Science & Technology

2007-03-01

proteasome. Mol. Cell, 6, 409–419. 14. Saeki, Y., Saitoh, A., Toh-e, A. & Yokosawa , H. (2002). Ubiquitin-like proteins and Rpn10 play cooperative...Sone, T., Toh-e, A. & Yokosawa , H. (2002). Identification of ubiquitin-like protein-binding sub- units of the 26 S proteasome. Biochem. Biophys. Res...Proteasome subunit Rpn1 binds ubiquitin-like protein domains. Nat Cell Biol 2002, 4:725-30. 15. Saeki Y, Sone T, Toh-e A, Yokosawa H: Identification of

Filter frequency response of time dependent signal using Laplace transform

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shestakov, Aleksei I.

We analyze the effect a filter has on a time dependent signal x(t). If X(s) is the Laplace transform of x and H (s) is the filter Transfer function, the response in frequency space is X (s) H (s). Consequently, in real space, the response is the convolution (x*h) (t), where hi is the Laplace inverse of H. Effects are analyzed and analytically for functions such as (t/t c) 2 e -t/tmore » $$_c$$, where t c = const. We consider lowpass, highpass and bandpass filters.« less

Precision measurement of the mass of the hc(1P1) state of charmonium.

PubMed

Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Libby, J; Powell, A; Wilkinson, G; Ecklund, K M; Love, W; Savinov, V; Lopez, A; Mendez, H; Ramirez, J; Ge, J Y; Miller, D H; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Artuso, M; Blusk, S; Khalil, S; Li, J; Mountain, R; Nisar, S; Randrianarivony, K; Sultana, N; Skwarnicki, T; Stone, S; Wang, J C; Zhang, L M; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Naik, P; Rademacker, J; Asner, D M; Edwards, K W; Reed, J; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Hunt, J M; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Ledoux, J; Mahlke-Krüger, H; Mohapatra, D; Onyisi, P U E; Patterson, J R; Peterson, D; Riley, D; Ryd, A; Sadoff, A J; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Athar, S B; Patel, R; Yelton, J; Rubin, P; Eisenstein, B I; Karliner, I; Mehrabyan, S; Lowrey, N; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Zweber, P

2008-10-31

A precision measurement of the mass of the h_{c}(1P1) state of charmonium has been made using a sample of 24.5x10;{6} psi(2S) events produced in e;{+}e;{-} annihilation at the Cornell Electron Storage Ring (CESR). The reaction used was psi(2S)-->pi;{0}h_{c}, pi;{0}-->gammagamma, h_{c}-->gammaeta_{c}, and the reaction products were detected in the CLEO-c detector. Data have been analyzed both for the inclusive reaction and for the exclusive reactions in which eta_{c} decays are reconstructed in 15 hadronic decay channels. Consistent results are obtained in the two analyses. The averaged results of the present measurements are M(h_{c})=3525.28+/-0.19(stat.)+/-0.12(syst.) MeV, and B(psi(2S)-->pi;{0}h_{c})xB(h_{c}-->gammaeta_{c})=(4.19+/-0.32+/-0.45)x10;{-4}. Using the ;{3}P_{J} centroid mass, DeltaM_{hf}(1P) identical withM(chi_{cJ})-M(h_{c})=+0.02+/-0.19+/-0.13 MeV.

Field implementation of fiber-reinforced polymer (FRP) deck panels.

DOT National Transportation Integrated Search

2017-06-01

Jeffery S. Volz, S.E., P.E., Ph.D., Kamal H. Khayat, PhD, P.Eng. http://orcid.org/0000-0003-1431-0715, Soo Duck Hwang, Ph.D. http://orcid.org/0000-0003-2178-1531, Hesham Tuwair, Ph.D., Jonathan T. Drury, Amy S. Crone : Although still in their infancy...

Scaling and memory in volatility return intervals in financial markets

NASA Astrophysics Data System (ADS)

Yamasaki, Kazuko; Muchnik, Lev; Havlin, Shlomo; Bunde, Armin; Stanley, H. Eugene

2005-06-01

For both stock and currency markets, we study the return intervals τ between the daily volatilities of the price changes that are above a certain threshold q. We find that the distribution function Pq(τ) scales with the mean return interval [Formula] as [Formula]. The scaling function f(x) is similar in form for all seven stocks and for all seven currency databases analyzed, and f(x) is consistent with a power-law form, f(x) ˜ x-γ with γ ≈ 2. We also quantify how the conditional distribution Pq(τ|τ0) depends on the previous return interval τ0 and find that small (or large) return intervals are more likely to be followed by small (or large) return intervals. This “clustering” of the volatility return intervals is a previously unrecognized phenomenon that we relate to the long-term correlations known to be present in the volatility. Author contributions: S.H. and H.E.S. designed research; K.Y., L.M., S.H., and H.E.S. performed research; A.B. contributed new reagents/analytic tools; A.B. analyzed data; and S.H. wrote the paper.Abbreviations: pdf, probability density function; S&P 500, Standard and Poor's 500 Index; USD, U.S. dollar; JPY, Japanese yen; SEK, Swedish krona.

Influence of chemical bonds on the lifetime of the molecular-field-split 2p levels in H{sub 2}S

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bueno, Andre Machado; Brito, Arnaldo Naves de; Fink, Reinhold F.

Different lifetime broadenings in molecular-field-split 2p core levels in H{sub 2}S are predicted theoretically and are identified in an experimental investigation of the S 2p Auger electron spectrum. The measurements were performed for the transition to the vibrationally resolved X{sup 1}A{sub 1} ground state of H{sub 2}S{sup 2+}. The lifetimes of the 3e{sub 1/2} and 5e{sub 1/2} levels of the 2p ionized molecule are found to be 64 and 74 meV, respectively. This unambiguous determination of the lifetime difference of 10{+-}1 meV is only possible as the 4e{sub 1/2}{yields}X{sup 1}A{sub 1}(2b{sub 1}{sup -2}) decay channel that overlaps the 5e{sub 1/2}{yields}X{supmore » 1}A{sub 1}(2b{sub 1}{sup -2}) channel is practically suppressed in Auger decay in H{sub 2}S. The lifetime difference is confirmed by ab initio calculations. A theoretical analysis shows that it results from the mutual orientation of the core hole in the intermediate states and the valence electron density in the sulfur 3p orbitals. Both are strongly influenced by the chemical bond. Thus the observed effect is the direct result of a fundamental property of molecular electronic structure.« less

2S protein Ara h 7.0201 has unique epitopes compared to other Ara h 7 isoforms and is comparable to 2S proteins Ara h 2 and 6 in basophil degranulation capacity.

PubMed

Hayen, S M; Ehlers, A M; den Hartog Jager, C F; Garssen, J; Knol, E F; Knulst, A C; Suer, W; Willemsen, L E M; Otten, H G

2018-07-01

Screening for specific IgE against 2S albumin proteins Ara h 2 and 6 has good positive predictive value in diagnosing peanut allergy. From the third 2S member Ara h 7, 3 isoforms have been identified. Their allergenicity has not been elucidated. This study investigated the allergenicity of Ara h 7 isoforms compared to Ara h 2 and 6. Sensitization of 15 DBPCFC-confirmed peanut-allergic patients to recombinant Ara h 2.0201, Ara h 6.01 and isoforms of recombinant Ara h 7 was determined by IgE immunoblotting strips. A basophil activation test (BAT) was performed in 9 patients to determine IgE-cross-linking capacities of the allergens. Sensitivity to the allergens was tested in 5 patients who were sensitized to at least 1 Ara h 7 isoform, by a concentration range in the BAT. 3D prediction models and sequence alignments were used to visualize differences between isoforms and to predict allergenic epitope regions. Sensitization to Ara h 7.0201 was most frequent (80%) and showed to be equally potent as Ara h 2.0201 and 6.01 in inducing basophil degranulation. Sensitization to Ara h 7.0201 together with Ara h 2.0201 and/or 6.01 was observed, indicating the presence of unique epitopes compared to the other 2 isoforms. Differences between the 3 Ara h 7 isoforms were observed in C-terminal cysteine residues, pepsin and trypsin cleavage sites and 3 single amino acid substitutions. The majority of peanut-allergic patients are sensitized to isoform Ara h 7.0201, which is functionally as active as Ara h 2.0201 and 6.01. Unique epitopes are most likely located in the C-terminus or an allergenic loop region which is a known allergenic epitope region for Ara h 2.0201 and 6.01. Due to its unique epitopes and allergenicity, it is an interesting candidate to improve the diagnostic accuracy for peanut allergy. © 2018 The Authors. Clinical & Experimental Allergy Published by John Wiley & Sons Ltd.

Nerve Agent Sensing Biopolymer Wipe

DTIC Science & Technology

2003-04-01

3. Urease and BChE (at two concentrations) activity as function of pH. ..... 10 Figure 4. Reaction scheme Agentase nerve agent sensor...11 Figure 5. Signal development in Agentase’s Traffic Light Sensor Construct.......... 11 Figure 6. Effect of BChE/ urease ...between two competing enzyme reactions. BChE catalyzed butyrylcholine hydrolysis results in the production of acid (decreasing pH) while urease - catalyzed

Topological Order in Silicon Photonics

DTIC Science & Technology

2017-02-07

photonic edge states and quantum emitters [ S. Barik , H. Miyake, W. DeGottardi, E. Waks and M. Hafezi, New J. Phys., 18, 11301 (2016) ]. Entanglement... Barik , H. Miyake, W. DeGottardi, E. Waks, and M. Hafezi “Two-Dimensionally Confined Topological Edge States in Photonic Crystals”, New J. Phys., 18

Nitric oxide-sensitive guanylyl cyclase is differentially regulated by nuclear and non-nuclear estrogen pathways in anterior pituitary gland.

PubMed

Cabilla, Jimena P; Nudler, Silvana I; Ronchetti, Sonia A; Quinteros, Fernanda A; Lasaga, Mercedes; Duvilanski, Beatriz H

2011-01-01

17β-estradiol (E2) regulates hormonal release as well as proliferation and cell death in the pituitary. The main nitric oxide receptor, nitric oxide sensitive- or soluble guanylyl cyclase (sGC), is a heterodimer composed of two subunits, α and β, that catalyses cGMP formation. α1β1 is the most abundant and widely expressed heterodimer, showing the greater activity. Previously we have shown that E2 decreased sGC activity but exerts opposite effects on sGC subunits increasing α1 and decreasing β1 mRNA and protein levels. In the present work we investigate the mechanisms by which E2 differentially regulates sGC subunits' expression on rat anterior pituitary gland. Experiments were performed on primary cultures of anterior pituitary cells from adult female Wistar rats at random stages of estrous cycle. After 6 h of E2 treatment, α1 mRNA and protein expression is increased while β1 levels are down-regulated. E2 effects on sGC expression are partially dependent on de novo transcription while de novo translation is fully required. E2 treatment decreased HuR mRNA stabilization factor and increased AUF1 p37 mRNA destabilization factor. E2-elicited β1 mRNA decrease correlates with a mRNA destabilization environment in the anterior pituitary gland. On the other hand, after 6 h of treatment, E2-BSA (1 nM) and E2-dendrimer conjugate (EDC, 1 nM) were unable to modify α1 or β1 mRNA levels, showing that nuclear receptor is involved in E2 actions. However, at earlier times (3 h), 1 nM EDC causes a transient decrease of α1 in a PI3k-dependent fashion. Our results show for the first time that E2 is able to exert opposite actions in the anterior pituitary gland, depending on the activation of classical or non-classical pathways. Thus, E2 can also modify sGC expression through membrane-initiated signals bringing to light a new point of regulation in NO/sGC pathway. © 2011 Cabilla et al.

Functionalized Graphene Reinforced Thermoplastic Nanocomposites as Strain Sensors in Structural Health Monitoring (Preprint)

DTIC Science & Technology

2012-02-01

2008, 3, 491-495. 5. S. Stankovich, D. A. Dikin , G. H. B. Dommett, K. M. Kohlhaas, E. J. Zimney, E. A. Stach, R. D. Piner, S. T. Nguyen and R. S...Eswaraiah, V. Sankaranarayanan and S. Ramaprabhu, Nanoscale Res. Lett., 2011, 6, 137. 14. T. Ramanathan, A. A. Abdala, S. Stankovich, D. A. Dikin , M. 5

Fission yeast translation initiation factor 3 subunit eIF3h is not essential for global translation initiation, but deletion of eif3h+ affects spore formation.

PubMed

Ray, Anirban; Bandyopadhyay, Amitabha; Matsumoto, Tomohiro; Deng, Haiteng; Maitra, Umadas

2008-11-01

The fission yeast Schizosaccharomyces pombe homologue of the p40/eIF3h subunit of mammalian translation initiation factor eIF3 has been characterized in this study. We show that this protein physically associates with the 40S ribosomal particles as a constituent of the multimeric eIF3 protein complex, which consists of all five known eIF3 core subunits (eIF3a, eIF3b, eIF3c, eIF3g and eIF3i) as well as the five non-core subunits (eIF3d, eIF3e, eIF3f, eIF3h and eIF3m) that constitute an eIF3 holocomplex in fission yeast. However, affinity purification of eIF3 from fission yeast cells expressing TAP-tagged eIF3h suggests the presence of distinct forms of eIF3 that differ in their composition of the non-core subunits. Further characterization of eIF3h shows that strains lacking eif3h(+) (eif3hDelta) are viable and show no gross defects, either in vegetative growth or in the rate of in vivo protein synthesis. Polysome profile analysis shows no apparent defects in translation initiation. Furthermore, deletion of eif3h(+) does not affect the ability of the other eIF3 subunits to remain associated with one another in a tight protein complex similar to the situation in wild-type cells. Additionally, we show that human eIF3h can functionally substitute fission yeast eIF3h in complementing in vivo a genetic deletion of eif3h(+). Interestingly, mutant eif3hDelta cells show several prominent phenotypic properties. They are hypersensitive to caffeine and highly defective in meiosis, producing either no spores or incomplete tetrads with a very high frequency. The implications of these results in relation to the functions of eIF3h in Sz. pombe are discussed. (c) 2008 John Wiley & Sons, Ltd.

Salmonella enterica Suppresses Pectobacterium carotovorum subsp. carotovorum Population and Soft Rot Progression by Acidifying the Microaerophilic Environment

PubMed Central

Kwan, Grace; Charkowski, Amy O.; Barak, Jeri D.

2013-01-01

ABSTRACT Although enteric human pathogens are usually studied in the context of their animal hosts, a significant portion of their life cycle occurs on plants. Plant disease alters the phyllosphere, leading to enhanced growth of human pathogens; however, the impact of human pathogens on phytopathogen biology and plant health is largely unknown. To characterize the interaction between human pathogens and phytobacterial pathogens in the phyllosphere, we examined the interactions between Pectobacterium carotovorum subsp. carotovorum and Salmonella enterica or Escherichia coli O157:H7 with regard to bacterial populations, soft rot progression, and changes in local pH. The presence of P. carotovorum subsp. carotovorum enhanced the growth of both S. enterica and E. coli O157:H7 on leaves. However, in a microaerophilic environment, S. enterica reduced P. carotovorum subsp. carotovorum populations and soft rot progression by moderating local environmental pH. Reduced soft rot was not due to S. enterica proteolytic activity. Limitations on P. carotovorum subsp. carotovorum growth, disease progression, and pH elevation were not observed on leaves coinoculated with E. coli O157:H7 or when leaves were coinoculated with S. enterica in an aerobic environment. S. enterica also severely undermined the relationship between the phytobacterial population and disease progression of a P. carotovorum subsp. carotovorum budB mutant defective in the 2,3-butanediol pathway for acid neutralization. Our results show that S. enterica and E. coli O157:H7 interact differently with the enteric phytobacterial pathogen P. carotovorum subsp. carotovorum. S. enterica inhibition of soft rot progression may conceal a rapidly growing human pathogen population. Whereas soft rotted produce can alert consumers to the possibility of food-borne pathogens, healthy-looking produce may entice consumption of contaminated vegetables. PMID:23404399

Final Environmental Impact Statement of the Proposed Ground Based Free Electron Laser Technology Integration Experiment, White Sands Missile Range, New Mexico

DTIC Science & Technology

1987-01-01

opa-Hzxi •H a-H «XI B • a -H -HTI p • B P a • o a-H u s pap >i o aoo xi c BBP u • b • •« • -H a a a e c a...M -»•!•_•• SaSJS *2-3s ~b >D o a K-S? • • as -« 8 2 Sol? 9 a •■)-* ffa ) •< a a --) *J • m «a «*-*> «-) a

Characterization of Nucleoside Reverse Transcriptase Inhibitor-Associated Mutations in the RNase H Region of HIV-1 Subtype C Infected Individuals.

PubMed

Ngcapu, Sinaye; Theys, Kristof; Libin, Pieter; Marconi, Vincent C; Sunpath, Henry; Ndung'u, Thumbi; Gordon, Michelle L

2017-11-08

The South African national treatment programme includes nucleoside reverse transcriptase inhibitors (NRTIs) in both first and second line highly active antiretroviral therapy regimens. Mutations in the RNase H domain have been associated with resistance to NRTIs but primarily in HIV-1 subtype B studies. Here, we investigated the prevalence and association of RNase H mutations with NRTI resistance in sequences from HIV-1 subtype C infected individuals. RNase H sequences from 112 NRTI treated but virologically failing individuals and 28 antiretroviral therapy (ART)-naive individuals were generated and analysed. In addition, sequences from 359 subtype C ART-naive sequences were downloaded from Los Alamos database to give a total of 387 sequences from ART-naive individuals for the analysis. Fisher's exact test was used to identify mutations and Bayesian network learning was applied to identify novel NRTI resistance mutation pathways in RNase H domain. The mutations A435L, S468A, T470S, L484I, A508S, Q509L, L517I, Q524E and E529D were more prevalent in sequences from treatment-experienced compared to antiretroviral treatment naive individuals, however, only the E529D mutation remained significant after correction for multiple comparison. Our findings suggest a potential interaction between E529D and NRTI-treatment; however, site-directed mutagenesis is needed to understand the impact of this RNase H mutation.

H.E.S.S. observations of the binary system PSR B1259-63/LS 2883 around the 2010/2011 periastron passage

NASA Astrophysics Data System (ADS)

H.E.S.S. Collaboration; Abramowski, A.; Acero, F.; Aharonian, F.; Akhperjanian, A. G.; Anton, G.; Balenderan, S.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker Tjus, J.; Bernlöhr, K.; Birsin, E.; Biteau, J.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Carrigan, S.; Casanova, S.; Cerruti, M.; Chadwick, P. M.; Chaves, R. C. G.; Cheesebrough, A.; Colafrancesco, S.; Cologna, G.; Conrad, J.; Couturier, C.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; deWilt, P.; Dickinson, H. J.; Djannati-Ataï, A.; Domainko, W.; Drury, L. O'C.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Egberts, K.; Eger, P.; Espigat, P.; Fallon, L.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Gast, H.; Giebels, B.; Glicenstein, J. F.; Glück, B.; Göring, D.; Grondin, M.-H.; Grudzińska, M.; Häer, S.; Hague, J. D.; Hahn, J.; Hampf, D.; Harris, J.; Heinz, S.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; Jahn, C.; Jamrozy, M.; Jung, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Khélifi, B.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kneiske, T.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Kossakowski, R.; Krayzel, F.; Krüger, P. P.; Lan, H.; Lamanna, G.; Lefaucheur, J.; Lemoine-Goumard, M.; Lenain, J.-P.; Lennarz, D.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Masbou, J.; Maurin, G.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Medina, M. C.; Méhault, J.; Menzler, U.; Moderski, R.; Mohamed, M.; Moulin, E.; Naumann, C. L.; Naumann-Godo, M.; de Naurois, M.; Nedbal, D.; Nguyen, N.; Niemiec, J.; Nolan, S. J.; Oakes, L.; Ohm, S.; de Oña Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Raue, M.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Ripken, J.; Rob, L.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sheidaei, F.; Skilton, J. L.; Sol, H.; Spengler, G.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Szostek, A.; Tavernet, J.-P.; Terrier, R.; Tluczykont, M.; Trichard, C.; Valerius, K.; van Eldik, C.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Völk, H. J.; Volpe, F.; Vorobiov, S.; Vorster, M.; Wagner, S. J.; Ward, M.; White, R.; Wierzcholska, A.; Willmann, P.; Wouters, D.; Zacharias, M.; Zajczyk, A.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.

2013-03-01

Aims: We present very high energy (VHE; E > 100 GeV) data from the γ-ray binary system PSR B1259-63/LS 2883 taken around its periastron passage on 15th of December 2010 with the High Energy Stereoscopic System (H.E.S.S.) of Cherenkov Telescopes. We aim to search for a possible TeV counterpart of the GeV flare detected by the Fermi LAT. In addition, we aim to study the current periastron passage in the context of previous observations taken at similar orbital phases, testing the repetitive behaviour of the source. Methods: Observations at VHEs were conducted with H.E.S.S. from 9th to 16th of January 2011. The total dataset amounts to ~6 h of observing time. The data taken around the 2004 periastron passage were also re-analysed with the current analysis techniques in order to extend the energy spectrum above 3 TeV to fully compare observation results from 2004 and 2011. Results: The source is detected in the 2011 data at a significance level of 11.5σ revealing an averaged integral flux above 1 TeV of (1.01 ± 0.18stat ± 0.20sys) × 10-12 cm-2 s-1. The differential energy spectrum follows a power-law shape with a spectral index Γ = 2.92 ± 0.30stat ± 0.20sys and a flux normalisation at 1 TeV of N0 = (1.95 ± 0.32stat ± 0.39sys) × 10-12 TeV-1 cm-2 s-1. The measured light curve does not show any evidence for variability of the source on the daily scale. The re-analysis of the 2004 data yields results compatible with the published ones. The differential energy spectrum measured up to ~10 TeV is consistent with a power law with a spectral index Γ = 2.81 ± 0.10stat ± 0.20sys and a flux normalisation at 1 TeV of N0 = (1.29 ± 0.08stat ± 0.26sys) × 10-12 TeV-1 cm-2 s-1. Conclusions: The measured integral flux and the spectral shape of the 2011 data are compatible with the results obtained around previous periastron passages. The absence of variability in the H.E.S.S. data indicates that the GeV flare observed by Fermi LAT in the time period covered also by H.E.S.S. observations originates in a different physical scenario than the TeV emission. Moreover, the comparison of the new results to the results from the 2004 observations made at a similar orbital phase provides a stronger evidence of the repetitive behaviour of the source.

Bibliography of Technical Publications and Papers October 1977 - September 1978

DTIC Science & Technology

1978-11-01

MCNUTT. Sweetness of fructose in a dry beverage base. Food Processing Industry, 47(555): 28-29 (1978). 91. KELCH, W. J., and J. S. LEE. Modeling...1978, pp. 510-513. 170. HARRIS, N. E. Sweeteners , noncarbohydrate (low concentra- tion). In Encyclopedia of Food Science. M. S. Peterson and A. H...Reports 188. BALL, D. H., and E. WETZEL. Liquid chromatographic analysis of the free sugars in sweet corn: A method indicative of maturity and of quality

Branching fractions for transitions of {psi}(2S) to J/{psi}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mendez, H.; Ge, J. Y.; Miller, D. H.

2008-07-01

We report determination of branching fractions for the decays {psi}(2S){yields}h+J/{psi}, where h=any, {pi}{sup +}{pi}{sup -}, {pi}{sup 0}{pi}{sup 0}, {eta}, {pi}{sup 0}, and {gamma}{gamma} through {chi}{sub c0,1,2}. These measurements use 27M {psi}(2S) decays produced in e{sup +}e{sup -} collision data collected with the CLEO detector. The resulting branching fractions and ratios thereof improve upon previously achieved precision in all cases, and in combination with other measurements permit determination of B({chi}{sub cJ}{yields}{gamma}J/{psi}) and B({psi}(2S){yields}light hadrons)

U.S. EPA, Pesticide Product Label, PURITY BACTERIOSTATIC WATER TREATMENT UNIT,MODEL 514C.C., 09/10/1982

EPA Pesticide Factsheets

2011-04-21

... [ .... EEO PL"',lI.', Pl:>1S:. .. · nAG.',EEJ A€~f)EA~''''ETTlE RE::'f-o':'::l P,G'.H:JR;)S",lhPEt. ... ','.! Pf" g':-'" iI~~~ 2.- ~~. I.~r 0" S' l_t e I.l'l ~aM;: .I.,. ...

Impact of aerosols and adverse atmospheric conditions on the data quality for spectral analysis of the H.E.S.S. telescopes

NASA Astrophysics Data System (ADS)

Hahn, J.; de los Reyes, R.; Bernlöhr, K.; Krüger, P.; Lo, Y. T. E.; Chadwick, P. M.; Daniel, M. K.; Deil, C.; Gast, H.; Kosack, K.; Marandon, V.

2014-02-01

The Earth's atmosphere is an integral part of the detector in ground-based imaging atmospheric Cherenkov telescope (IACT) experiments and has to be taken into account in the calibration. Atmospheric and hardware-related deviations from simulated conditions can result in the mis-reconstruction of primary particle energies and therefore of source spectra. During the eight years of observations with the High Energy Stereoscopic System (H.E.S.S.) in Namibia, the overall yield in Cherenkov photons has varied strongly with time due to gradual hardware aging, together with adjustments of the hardware components, and natural, as well as anthropogenic, variations of the atmospheric transparency. Here we present robust data selection criteria that minimize these effects over the full data set of the H.E.S.S. experiment and introduce the Cherenkov transparency coefficient as a new atmospheric monitoring quantity. The influence of atmospheric transparency, as quantified by this coefficient, on energy reconstruction and spectral parameters is examined and its correlation with the aerosol optical depth (AOD) of independent MISR satellite measurements and local measurements of atmospheric clarity is investigated.

Diffuse Cosmic Rays Shining in the Galactic Center: A Novel Interpretation of H.E.S.S. and Fermi-LAT γ-Ray Data.

PubMed

Gaggero, D; Grasso, D; Marinelli, A; Taoso, M; Urbano, A

2017-07-21

We present a novel interpretation of the γ-ray diffuse emission measured by Fermi-LAT and H.E.S.S. in the Galactic center (GC) region and the Galactic ridge (GR). In the first part we perform a data-driven analysis based on PASS8 Fermi-LAT data: We extend down to a few GeV the spectra measured by H.E.S.S. and infer the primary cosmic-ray (CR) radial distribution between 0.1 and 3 TeV. In the second part we adopt a CR transport model based on a position-dependent diffusion coefficient. Such behavior reproduces the radial dependence of the CR spectral index recently inferred from the Fermi-LAT observations. We find that the bulk of the GR emission can be naturally explained by the interaction of the diffuse steady-state Galactic CR sea with the gas present in the central molecular zone. Although we confirm the presence of a residual radial-dependent emission associated with a central source, the relevance of the large-scale diffuse component prevents to claim a solid evidence of GC pevatrons.

Scaling of X-Ray Preionized Mercury Bromide Lasers

DTIC Science & Technology

1981-11-01

H £* [ft T3 (0 0) H Q) W (d U w w S Ü 1° in W...CM I |M (U ■ H I fa 2-11 Table 2-4 Comparison of HgBr Discharge Lasers Laboratory NOSC MSNW Type Ionization Source Length/Energy...o o CN m in CN co r- o o o, i- H CN CO ^ ^ h > t^ +-^ e <-J W ^ in o E-i dP U <: D •—" « EH d< W .J H X 53 O P u W > O D W > H

Can News Draw Blood The Impact of Media Coverage on the Number and Severity of Terror Attacks

DTIC Science & Technology

2016-05-01

groups devote to carrying out attacks, p are the costs of a single attack, and E measures the effectiveness of terrorist attacks, e.g. the average...8i) h A. h · A ( b) (r r ) A 2(a+b)JP , w ere IS t e expressiOn = a+ jP u3 + s- u1 . s A2 + 4bEw > 0, all three eigenvalues will be elements of the...May 2016 164 Jahn, Vera ; Steinhardt, Max Friedrich : Innovation and Immigration - Insights from a Placement Policy, February 2016 163 Beckmann

Effects of the Variable Lorentz Force on the Critical Current in Anisotropic Superconducting Thin Films (Postprint)

DTIC Science & Technology

2007-06-01

Phys. Lett., vol. 87, p. 162505, 2005. [2] J. L. Macmanus-Driscoll, S. R. Foltyn, Q. X. Jia, H. Wang, A. Serquis, L. Civale, B. Maiorov, M. E. Hawley ...B. Maiorov, L. Civale, Y. Lin, M. E. Hawley , M. P. Maley, and D. E. Peterson, “Systematic enhancement of in-field critical current density with rare...16, p. 162 507–1, 2005. [15] H. Safar, J. Y. Coulter, M. P. Maley, S. R. Foltyn, P. N. Arendt, X. D. Wu, and J. O. Willis , “Anisotropy and Lorentz

Motivation: A Seminar to Assist Charge Nurses in Understanding Motivation and Worker Behavior

DTIC Science & Technology

1988-05-01

c . Growth needs - need for personal growth and development. 0 2. Alderfer - believes...H 0s 0. rj 4 a3Lr ()3 0 L) 0 -P E000 0) - - -O൱ =1 0 -j Ln - .0 03 0:44 U- 0 -a 6 .1-. c 41 0 c Ii - - u t- <I, LO0 E D, fn 441 0~-t 0 0~( 1-a-i-I...U -7- 0 Fi1aU 0C >. 0 s .0> 0 .0 -,~~L -.. 0~~a tn V wC co c 0 >4 u t4 _-.,d ~ ’ C OC)o E LL 0C) 4J. -H - C C ) -, E - E 00 Z C a 0 C )

Tuning Carrier Tunneling in van der Waals Heterostructures for Ultrahigh Detectivity.

PubMed

Vu, Quoc An; Lee, Jin Hee; Nguyen, Van Luan; Shin, Yong Seon; Lim, Seong Chu; Lee, Kiyoung; Heo, Jinseong; Park, Seongjun; Kim, Kunnyun; Lee, Young Hee; Yu, Woo Jong

2017-01-11

Semiconducting transition metal dichalcogenides (TMDs) are promising materials for photodetection over a wide range of visible wavelengths. Photodetection is generally realized via a phototransistor, photoconductor, p-n junction photovoltaic device, and thermoelectric device. The photodetectivity, which is a primary parameter in photodetector design, is often limited by either low photoresponsivity or a high dark current in TMDs materials. Here, we demonstrated a highly sensitive photodetector with a MoS 2 /h-BN/graphene heterostructure, by inserting a h-BN insulating layer between graphene electrode and MoS 2 photoabsorber, the dark-carriers were highly suppressed by the large electron barrier (2.7 eV) at the graphene/h-BN junction while the photocarriers were effectively tunneled through small hole barrier (1.2 eV) at the MoS 2 /h-BN junction. With both high photocurrent/dark current ratio (>10 5 ) and high photoresponsivity (180 AW -1 ), ultrahigh photodetectivity of 2.6 × 10 13 Jones was obtained at 7 nm thick h-BN, about 100-1000 times higher than that of previously reported MoS 2 -based devices.

Hydrogen bonded C-H···Y (Y = O, S, Hal) molecular complexes: A natural bond orbital analysis

NASA Astrophysics Data System (ADS)

Isaev, A. N.

2016-03-01

Hydrogen bonded C-H···Y complexes formed by H2O, H2S molecules, hydrogen halides, and halogen-ions with methane, halogen substituted methane as well as with the C2H2 and NCH molecules were studied at the MP2/aug-cc-pVDZ level. The structure of NBOs corresponding to lone pair of acceptor Y, n Y, and vacant anti-σ-bond C-H of proton donor was analyzed and estimates of second order perturbation energy E(2) characterizing donor-acceptor n Y → σ C-H * charge-transfer interaction were obtained. Computational results for complexes of methane and its halogen substituted derivatives show that for each set of analogous structures, the EnY→σ*C-H (2) energy tends to grow with an increase in the s-component percentage in the lone pair NBO of acceptor Y. Calculations for different C···Y distances show that the equilibrium geometries of complexes lie in the region where the E(2) energy is highest and it changes symbatically with the length of the covalent E-H bond when the R(C···Y) distance is varied. The performed analysis allows us to divide the hydrogen bonded complexes into two groups, depending on the pattern of overlapping for NBOs of the hydrogen bridge.

Synthesis of Rapamycin Derivatives Containing the Triazole Moiety Used as Potential mTOR-Targeted Anticancer Agents.

PubMed

Xie, Lijun; Huang, Jie; Chen, Xiaoming; Yu, Hui; Li, Kualiang; Yang, Dan; Chen, Xiaqin; Ying, Jiayin; Pan, Fusheng; Lv, Youbing; Cheng, Yuanrong

2016-06-01

Rapamycin, a potent antifungal antibiotic, was approved as immunosuppressant, and lately its derivatives have been developed into mTOR targeting anticancer drugs. Structure modification was performed at the C-42 position of rapamycin, and a novel series of rapamycin triazole hybrids (4a-d, 5a-e, 8a-e, and 9a-e) was facilely synthesized via Huisgen's reaction. The anticancer activity of these compounds was evaluated against the Caski, H1299, MGC-803, and H460 human cancer cell lines. Some of the derivatives (8a-e, 9a-e) appeared to have stronger activity than that of rapamycin; however, 4a-d and 5a-e failed to show potential anticancer activity. Compound 9e with a (2,4-dichlorophenylamino)methyl moiety on the triazole ring was the most active anticancer compound, which showed IC50 values of 6.05 (Caski), 7.89 (H1299), 25.88 (MGC-803), and 8.60 μM (H460). In addition, research on the mechanism showed that 9e was able to cause cell morphological changes and to induce apoptosis in the Caski cell line. Most importantly, 9e can decrease the phosphorylation of mTOR and of its downstream key proteins, S6 and P70S6K1, indicating that 9e can effectively inhibit the mTOR signaling pathway. Thus, it may have the potential to become a new mTOR inhibitor against various cancers. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Optimization of low-temperature blanching combined with calcium treatment to inactivate Escherichia coli O157:H7 on fresh-cut spinach.

PubMed

Kim, N H; Lee, N Y; Kim, S H; Lee, H J; Kim, Y; Ryu, J H; Rhee, M S

2015-07-01

To develop a mild blanching method with calcium salts to ensure microbiological safety and quality of fresh-cut spinach. The antimicrobial efficacy of eight calcium salts was evaluated on Escherichia coli O157:H7 at 45-65°C and calcium hydroxide (Ca(OH)2 ) showed the greatest synergistic antimicrobial effect with heat. Combinations of low temperature treatments (45, 55, 65°C), time (20, 40, 60 s) and Ca(OH)2 (0·25, 0·50, 0·75%) were applied for E. coli O157:H7 disinfection on fresh-cut spinach to develop a predictive model using a Box-Behnken experimental design. A suitable quadratic model was produced (R(2) = 0·98, P < 0·001) and the optimum condition (64·9°C with 0·52% Ca(OH)2 for 42·4 s) was drawn by reducing 6·6 log CFU g(-1) of E. coli O157:H7 on fresh-cut spinach. Blanching at 61·9°C with 0·52% Ca(OH)2 for 41·7 s can inactivate E. coli O157:H7 on spinach by 5·4 log CFU g(-1) . The new method was comparable to the CDC recommendation for safe spinach cooking (71·1°C, 15 s; 5·0 log CFU g(-1) reduction) with lower levels of weight loss of the spinach (P < 0·05). This study suggests an efficient spinach blanching method for E. coli O157:H7 disinfection. This blanching method will enhance microbiological safety of fresh-cut produce while minimizing the use of energy and chemicals. © 2015 The Society for Applied Microbiology.

OMEGA Navigation System Synchronization

DTIC Science & Technology

1982-12-01

DEC 1982 2. REPORT TYPE 3. DATES COVERED 00-00-1982 to 00-00-1982 4. TITLE AND SUBTITLE OMEGA Navigation System Synchronization 5a. CONTRACT...l execution of ONSOD’s annual $5 mi l l ion budget. OMEGA SYSTEM SYNCHRONIZATION One of ONSOD’s p r inc ipa l missions i s t o ensure the...OMEGA system i s maintained within es tabl ished timing t o l e r a ~ c e s . A l l OMEGA s t a t i o n s transmissions a r e synchronized , so t h

Modeling and Simulation of Ceramic Arrays to Improve Ballaistic Performance

DTIC Science & Technology

2013-09-01

2219 , 2000. -Boundary conditions were modified in order to achieve better...a . 3 0) E o 0 da tio n im en ts ■ co nd iti tt er d a al ys is i at e ri al If- sy m m pt h o f P ge ts w it c CD in g S P...H M od el v al i< D oP e xp er 22 19 ,2 00 0 CO 0 ■o > C 0 3 "E rt h er a n ec t o f m (0 CD £ IQ J2. 0) ■Q E CO 3 o

31 CFR 315.30 - Series E bonds and savings notes.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT REGULATIONS GOVERNING U.S. SAVINGS BONDS, SERIES A, B, C, D, E, F, G, H, J, AND K, AND U.S. SAVINGS NOTES Interest § 315.30 Series E bonds... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Series E bonds and savings notes. 315...

Scaling laws in decaying helical hydromagnetic turbulence

NASA Astrophysics Data System (ADS)

Christensson, M.; Hindmarsh, M.; Brandenburg, A.

2005-07-01

We study the evolution of growth and decay laws for the magnetic field coherence length ξ, energy E_M and magnetic helicity H in freely decaying 3D MHD turbulence. We show that with certain assumptions, self-similarity of the magnetic power spectrum alone implies that ξ σm t1/2. This in turn implies that magnetic helicity decays as Hσm t-2s, where s=(ξ_diff/ξH)2, in terms of ξ_diff, the diffusion length scale, and ξ_H, a length scale defined from the helicity power spectrum. The relative magnetic helicity remains constant, implying that the magnetic energy decays as E_M σm t-1/2-2s. The parameter s is inversely proportional to the magnetic Reynolds number Re_M, which is constant in the self-similar regime.

Collisions of slow ions C3Hn+ and C3Dn+ (n = 2-8) with room temperature carbon surfaces: mass spectra of product ions and the ion survival probability.

PubMed

Pysanenko, Andriy; Zabka, Jan; Feketeová, Linda; Märk, Tilmann D; Herman, Zdenek

2008-01-01

Collisions of C3Hn+ (n = 2-8) ions and some of their per- deuterated analogs with room temperature carbon (HOPG) surfaces (hydrocarbon-covered) were investigated over the incident energy range 13-45 eV in beam scattering experiments. The mass spectra of product ions were measured and main fragmentation paths of the incident projectile ions, energized in the surface collision, were determined. The extent of fragmentation increased with increasing incident energy. Mass spectra of even-electron ions C3H7+ and C3H5+ showed only fragmentations, mass spectra of radical cations C3H8*+ and C3H6*+ showed both simple fragmentations of the projectile ion and formation of products of its surface chemical reaction (H-atom transfer between the projectile ion and hydrocarbons on the surface). No carbon-chain build-up reaction (formation of C4 hydrocarbons) was detected. The survival probability of the incident ions, S(a), was usually found to be about 1-2% for the radical cation projectile ions C3H8*+, C3H6*+, C3H4*+ and C3H2*+ and several percent up to about 20% for the even-electron projectile ions C3H7+, C3H5+, C3H3+. A plot of S(a) values of C1, C2, C3, some C7 hydrocarbon ions, Ar+ and CO2+ on hydrocarbon-covered carbon surfaces as a function of the ionization energies (IE) of the projectile species showed a drop from about 10% to about 1% and less at IE 8.5-9.5 eV and further decrease with increasing IE. A strong correlation was found between log S(a) and IE, a linear decrease over the entire range of IE investigated (7-16 eV), described by log S(a) = (3.9 +/- 0.5)-(0.39 +/- 0.04) IE.

Knowledge, Skills, Abilities, and Other Characteristics for Remotely Piloted Aircraft Pilots and Operators

DTIC Science & Technology

2011-10-19

Editor Dr. Gregory Manley HQ AFPC/DSYX, Dr. Lisa Mills AF/A1PF, Dr. Paul DiTullio HQ Af/A1PFA, Kenneth Schwartz HQ AFPC/DSYX, Johnny Weissmuller HQ...B ru s k ie w ic z e t a l. , 2 0 0 7 : A V O , M P O C h a p p e ll e e t a l. , 2 0 1 0 : M P O C h a p p e ll e e t a l. , 2 0 1 1

Simulators Sustainment Management: Advanced Planning Information

DTIC Science & Technology

2006-05-23

1M per year Competition Type: TSA II Small Business Set-A-Side, FFP Program Mgr : James H. Burks,507 ACSS/GFLC, (801) 586-1859; jim.burks...ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13...BEST O G D E N A I R L O G I S T I C S C E N T E R Training Systems Business Opportunities FY06-07 HC-130P Weapon System Trainer T-38C Aircrew

17 beta-estradiol modifies nitric oxide-sensitive guanylyl cyclase expression and down-regulates its activity in rat anterior pituitary gland.

PubMed

Cabilla, Jimena P; Díaz, María del Carmen; Machiavelli, Leticia I; Poliandri, Ariel H; Quinteros, Fernanda A; Lasaga, Mercedes; Duvilanski, Beatriz H

2006-09-01

Previous studies showed that 17 beta-estradiol (17 beta-E2) regulates the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP pathway in many tissues. Evidence from our laboratory indicates that 17 beta-E2 disrupts the inhibitory effect of NO on prolactin release, decreasing sGC activity and affecting the cGMP pathway in anterior pituitary gland of adult ovariectomized and estrogenized rats. To ascertain the mechanisms by which 17 beta-E2 affects sGC activity, we investigated the in vivo and in vitro effects of 17 beta-E2 on sGC protein and mRNA expression in anterior pituitary gland from immature female rats. In the present work, we showed that 17 beta-E2 acute treatment exerted opposite effects on the two sGC subunits, increasing alpha1 and decreasing beta1 subunit protein and mRNA expression. This action on sGC protein expression was maximal 6-9 h after 17 beta-E2 administration. 17beta-E2 also caused the same effect on mRNA expression at earlier times. Concomitantly, 17 beta-E2 dramatically decreased sGC activity 6 and 9 h after injection. These effects were specific of 17 beta-E2, because they were not observed with the administration of other steroids such as progesterone and 17 alpha-estradiol. This inhibitory action of 17beta-E2 on sGC also required the activation of estrogen receptor (ER), because treatment with the pure ER antagonist ICI 182,780 completely blocked 17 beta-E2 action. 17 beta-E2 acute treatment caused the same effects on pituitary cells in culture. These results suggest that 17 beta-E2 exerts an acute inhibitory effect on sGC in anterior pituitary gland by down-regulating sGC beta 1 subunit and sGC activity in a specific, ER-dependent manner.

The variability and IRI2007-predictability of hmF2 over South Africa

NASA Astrophysics Data System (ADS)

Mbambo, M. C.; McKinnell, Lee-Anne; Habarulema, J. B.

2013-11-01

This paper presents an investigation into the variability and predictability of the maximum height of the ionospheric F2 layer, hmF2 over the South African region. Data from three South African stations, namely Madimbo (22.4°S, 26.5°E, dip angle: -61.47°), Grahamstown (33.3°S, 26.5°E, dip angle: -64.08°) and Louisvale (28.5°S, 21.2°E, dip angle: -65.44°) were used in this study. The results indicate that hmF2 shows a larger variability around midnight than during the daytime for all seasons. Monthly median hmF2 values were used in all cases and were compared with predictions from the IRI-2007 model, using the URSI (Union Radio-Scientifique Internationale) coefficient option. The analysis covers the diurnal and seasonal hourly hmF2 values for the selected months and time sectors e.g. January, July, April and October for 2003 and 2005. The time ranges between (03h00-23h00 UT; LT = UT + 2h) representing the local sunrise, midday, sunset and midnight hours. The time covers sunrise, midday, sunrise, and midnight hours (03-06h00 UT, 07-11h00 UT, sunrise 16-18h00 UT and 22-23h00 UT; LT = UT + 2h). The dependence of the results on solar activity levels was also investigated. The IRI-2007 predictions follow fairly well the diurnal and seasonal variation patterns of the observed hmF2 values at all the stations. However, the IRI-2007 model overestimates and underestimates the hmF2 value during different months for all the solar activity periods.

Divergence of the long-wavelength collective diffusion coefficient in quasi-one- and quasi-two-dimensional colloidal suspensions.

PubMed

Lin, Binhua; Cui, Bianxiao; Xu, Xinliang; Zangi, Ronen; Diamant, Haim; Rice, Stuart A

2014-02-01

We report the results of experimental studies of the short-time-long-wavelength behavior of collective particle displacements in quasi-one-dimensional (q1D) and quasi-two-dimensional (q2D) colloid suspensions. Our results are reported via the q → 0 behavior of the hydrodynamic function H(q) that relates the effective collective diffusion coefficient D(e)(q), with the static structure factor S(q) and the self-diffusion coefficient of isolated particles D(0): H(q) ≡ D(e)(q)S(q)/D(0). We find an apparent divergence of H(q) as q → 0 with the form H(q) ∝ q(-γ) (1.7 < γ < 1.9) for both q1D and q2D colloid suspensions. Given that S(q) does not diverge as q → 0 we infer that D(e)(q) does. This behavior is qualitatively different from that of the three-dimensional H(q) and D(e)(q) as q → 0, and the divergence is of a different functional form from that predicted for the diffusion coefficient in one-component one-dimensional and two-dimensional fluids not subject to boundary conditions that define the dimensionality of the system. We provide support for the contention that the boundary conditions that define a confined system play a very important role in determining the long-wavelength behavior of the collective diffusion coefficient from two sources: (i) the results of simulations of H(q) and D(e)(q) in quasi-1D and quasi-2D systems and (ii) verification, using data from the work of Lin, Rice and Weitz [Phys. Rev. E 51, 423 (1995)], of the prediction by Bleibel et al., arXiv:1305.3715, that D(e)(q) for a monolayer of colloid particles constrained to lie in the interface between two fluids diverges as q(-1) as q → 0.

Combat History Analysis Study Effort (CHASE)

DTIC Science & Technology

1986-08-01

DE ; DEC JAN FEB JUL 2 8 KIMBERLY 11 KIHBERLY 15 LADYSMITH 24 LADYSHITH 18 LADYSHITH 1 SANTIAGO ...dates over time, along with some other des - criptive statistics of the material in the HERO data base, is discussed in Chapter 3. The HERO data base...Engagement O ■’-4 II i *J o ■H -H ^ ^. —1 U It For ce Pr ep on - de ra nc e 1 a V 2 .5 i2S it s o ’Si in’ S tH 71 u ■H 3 iW

1. Historic American Buildings Survey E.H. Pickering, Photographer Sept. 1936 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey E.H. Pickering, Photographer Sept. 1936 NOW FEDERAL PROPERTY BUILT AT VARIOUS TIMES AS LATE AS 1870? Note: Research tends to show buildings are of Post-Revolution date. - Catoctin Furnace, Stack No. 2, U. S. Route 15, Catoctin Furnace, Frederick County, MD

U.S. EPA, Pesticide Product Label, PCO LINDANE E-1 INSECTICIDE, 09/21/1983

EPA Pesticide Factsheets

2011-04-13

... lid '",1. Uu (e, .~~ • I"I. ~ii.r in ... ,,1".1'~ ... In "'"uh' .... h._H ... l .... CI • .!!. I .. ,.oCll'. '1. II ,11_ •• , 1.1 ..... 1"".1 "1~~lIh" .., hl"'''5 It hrM'. ...

Model representations for systems of selfadjoint operators satisfying commutation relations

NASA Astrophysics Data System (ADS)

Zolotarev, Vladimir A.

2010-12-01

Model representations are constructed for a system \\{B_k\\}_1^n of bounded linear selfadjoint operators in a Hilbert space H such that \\displaystyle \\lbrack B_k,B_s \\rbrack =\\frac i2\\varphi^*R_{k,s}^-\\varphi, \\qquad\\sigma_k\\varphi B_s-\\sigma_s\\varphi B_k=R_{k,s}^+\\varphi, \\displaystyle \\sigma_k\\varphi\\varphi^*\\sigma_s-\\sigma_s\\varphi\\varphi^*\\sigma_k=2iR_{k,s}^-,\\qquad1\\le k, s\\le n, where \\varphi is a linear operator from H into a Hilbert space E and \\{\\sigma_k,R_{k,s}^+/-\\}_1^n are some selfadjoint operators in E. A realization of these models in function spaces on a Riemann surface is found and a full set of invariants for \\{B_k\\}_1^n is described. Bibliography: 11 titles.

Automated M55 Detonator Production Equipment. Volume 1

DTIC Science & Technology

1987-05-01

i 41 •8 e o C u 01 o « v 01 & u a e. e < < •^ ec GO PI t^ r » fs o> ^ « •* ■ff w ■H cc...cl 4J C m e e u (0 0 9 e u « r o 4J u u 0 O CO X z e 09 I 1 6C 0) 4J c 09 C U •H •* 0 m •w W 0B U 01 IH 09 ■HOC...00 2 O CO 3 u -»^< r > 5 Q QTZQ + i m ^- ro 3ZtO O o ^ ’ O o UJO < Q: ui _i ou. M 0 s 0 u 01 T5 « M R « •? A s 3 9 IT»

Mathematical Theory of Laminar Combustion. 8. Ignition and Explosion

DTIC Science & Technology

1980-03-01

found to be governed by 1i d2/dE - de with 6 and ( 12 ) df/dg =(- )/2T0 + (i) as g. -- ,o 0 for g =0, where the first boundary condition comes from matching...the maximum 0; and to satisfy the conditions S"( 12 ) must set -- ’:L . (la) 2 e@O h 1 / 2 Jehl_-O2 (114) -T e 0 and = 2’ .ech e Since vanishes at the...corresponding to reactant depletion; ensures that it does not go beyond H0; in fact it rapidly approaches H0 (exponentially in time).I0 LL________ - 12

Annual Trauma Anesthesia and Critical Care Symposium (6th) Held in Baltimore, MD on 20-23 May 1993

DTIC Science & Technology

1993-10-01

increasing intracranial pressure, and increased metabolic demand (e.g. seizures or fever ), however, may be attenuated with appropriate care. In...Dyspnea C. Cyanosis D. Headache E. Irritability F. Confusion G. Tachycardia S H. Pyrexia I. Petechial Rash VII. Clinical Findings (Severe F.E.S.) A...Frank Pulmonary Edema B. Convulsions/Coma C. ECG Showing Right Heart Strain D. Pyrexia E. Petechial Hemorrhage F. Jaundice G. Renal Impairment S O

Synthesis, characterization, computational studies and biological evaluation of S-benzyl-β-N-[3-(4-hydroxy-3-methoxy-phenylallylidene)]dithiocarbazate

NASA Astrophysics Data System (ADS)

Bhat, Rayees A.; Kumar, D.; Malla, Manzoor A.; Bhat, Sami U.; Khan, Md Shahzad; Manzoor, Ovais; Srivastava, Anurag; Naikoo, Rawoof A.; Mohsin, Mohd; Mir, Muzzaffar A.

2018-03-01

S-Benzyl-β-N-[3-(4-hydroxy-3-methoxy-phenylallylidene)]dithiocarbazate (HL1), Schiff base of S-benzyl dithiocarbazate, was synthesized by 1:1 condensation between S-benzyl dithiocarbazate and 4-hydroxy-3-methoxy cinnamaldehyde. The nitrogen-sulfur Schiff base (HL1) was characterized by Mass, FT-IR, H1-NMR, Raman, and UV-VIS spectroscopic techniques. Theoretical quantum chemical calculations were performed using DFT in combination with B3LYP exchange correlation functional and 6-311++ G (d, p) basis sets level. The calculated values of chemical potential (μ), HOMO-LUMO energy gap, chemical hardness, softness (S), ionization energy (IE), electron affinity (EA), dipole moment (D) and relative stabilization energy of the compound were 0.14881 eV, 0.12542 eV, 0.06271 eV, 3.37299 eV, -0.21152 eV, -0.08610 eV, 4.4090 Debye and -1753.350 eV respectively. Theoretically calculated parameters like H1-NMR, FT-IR, UV-VIS, Raman, electrostatic potential and HOMO-LUMO energy gap are in good agreement with experimental results. Also, in-vitro cytotoxicity studies were done against two habitually infection causing bacteria strains including gram-positive (S. aureus) and gram-negative (E. coli) for antibacterial activity. The results showed appreciable biological activity and the activity increased with increase in dose.

On the Robustness of Herlihy’s Hierarchy

DTIC Science & Technology

1993-03-01

s op ’. 5 Thus, the order...includes all complete operations in H. 2. if two operations op and op’ are in S , op < s op ’ if and only if response of op precedes the response of op...in S different from (eý’, eje), op < S op ’ if and only if the response of op precedes the response of op’ in H. It is easy to verify that (i) S is

Collision energy dependence of the reactions of metastable neon with small molecules

NASA Astrophysics Data System (ADS)

Noroski, Joseph H.

The reaction dynamics of Ne* (2p53 s 3P2, 3 P0) + X → [NeX]+ + e- (X = H2, CO, N2, NO, O2, CO 2, and C2H2) were studied with supersonic beams at various collision energies (E) via electron spectroscopy. Increasing E decreases the interparticle distance at which ionization occurs, allowing for exploration of the reaction potential energy surfaces via the kinetic energy epsilon of the ejected electron. Data were fit to give vibrational populations and line shifts (Deltaepsilons ), the difference between the excitation energy of Ne* and the vibronic energy of the target molecules, where vibronic excitation is due to Ne*. The resulting populations were compared to calculated or experimental Franck-Condon factors (FCfs), and vibrational progressions were identified. Deviation from Franck-Condon (FC) behavior was observed in all cases except for C2H 2, and all spectra at all E showed a blue shift except CO2. With increasing E, Deltaepsilons for H2 +, CO+, and N2 + increased with increasing E, while Deltaepsilon s decreased for NO+ and C2H2 +. The CO2+ spectra revealed a nearly constant red shift for the lowest three E and a blue shift for the highest E. O2+ showed a very small blue shift, but the O2+ populations were not determined due to an underlying continuum. Penning, excitation transfer, and ion-pair mechanisms are the most widely accepted for the reactions of metastable atoms. The closed-shell structure of H2, CO, and N2 and the large, increasing Deltaepsilon s suggest that their Ne* reactions proceed via the Penning mechanism. The open-shell structure of NO and its decreasing Deltaepsilons indicates changing dynamics and possibly also competition between all three mechanisms for Ne* + NO. The very small Deltaepsilons for O 2+ implies the excitation transfer mechanism for Ne* + O2. Ne* reactions with CO2 and C2H 2 both exhibited constant Deltaepsilons values for more than one E. This suggests that an excitation transfer mechanism is at work in these systems, but changes in Deltaepsilons at other E indicate that competing mechanisms may also be relevant. Lastly, a retrospective on authoring a solutions manual for a freshman chemistry textbook is offered.

East Europe Report

DTIC Science & Technology

1986-10-17

u CD O cn en r*^ CL) id cti ■ u CO 4- 1 o 3 O M 1 or a K ft ft cn \\opi o a \\Kfl T71233E ^ STBSajOUJvl ^ s ... u H QJ 4- 1 C •H i3 CD O = 1 13 O U ft PH g m o OJ i-H !■ o o >> n 4- 1 m 13 T3 o o Ö •H <D C/3 H +J M fl M a ) o... a > s < U

Instructor-Simulator Interface Design

DTIC Science & Technology

1981-04-01

AIR FORCE P I X - H I NSTI{ t(21"()1{-. 1 I NI IA THiFACE D)ESIGN M M (A E leh’i’rois 1.1d. V.(). Mix\\ 1110). Saiiit-iauremn ii il \\l.’l Qtliv’e A...C> E p S LABORATORY C. AIR FORCE SYSTEMS COMMAND / BROOKS AIR FORCE BASE,TEXAS 78235gl 5i3 02 NOIC N()°I’I( :1’:t; ¢ ’’ : When I .5. (;S.q ernmet dra...erniment Iliere.h inrs. v resion.,ililit ior ill. obligation ,iat.o eer. and liwi’ fai that the (,ovi rn t mian hl e firmulate. furnished. iir in an% %a

High Resolution Transmission Measurements of the Atmosphere in the Infrared.

DTIC Science & Technology

1978-04-28

modifications to the various spect rorn et r ic installations , cu r r en t l y operated to obtain very hi g h resolution solar spectra in the in f r a...record the solar spectrum in the ~‘. 3000 to ~ 10 , 000 A reg ion , has also been equipped with an InSb detector to recorc various series of spectra near...in~ s c o n c e r n i n & HF , HC 1, also met hy l-ch lor ide (CH 3C1), e t c . . . L t h e r s tudies oased on our i n f r a r e d solar ou se

Calcifications valvulaires chez l'hémodialysé au Maroc

PubMed Central

Noto-Kadou-Kaza, Béfa; Abouamrane, Lalla Meryam; Mtiou, Naoufal; El Khaya, Selma; Zamd, Mohamed; Medkouri, Ghislaine; Bengahanem, Mohamed Gharbi; Ramdani, Benyounes

2016-01-01

Introduction Les calcifications valvulaires constituent une des complications cardiovasculaires majeures de l'hémodialysé de par sa prévalence et son caractère prédictif de morbidité et de mortalité. De nombreux facteurs de risque sont à l'origine de ces calcifications. Le but de notre étude est d’évaluer à la fois la prévalence des calcifications valvulaires chez nos patients hémodialysés ainsi que leurs facteurs de risque. Méthodes Il s'agissait d'une étude transversale monocentrique, descriptive et analytique, ayant inclus 111 patients adultes hémodialysés depuis plus de 6 mois au centre d'hémodialyse du CHU Ibn Rochd de Casablanca et qui ont eu à bénéficier d'une ETT durant l'année 2013. Résultats L’âge moyen de nos patients était de 44 ± 14 ans. L'ancienneté moyenne en hémodialyse était de 146 ± 80 mois. La pression artérielle moyenne était de 123 ± 23 mmHg pour la systolique et de 72 ± 13 mmHg pour la diastolique, la PTHi moyenne de 529±460 pg/ml, la calcémie moyenne de 86±10 mg/l et la phosphatémie moyenne de 40±15 mg/l. La CRP moyenne était de 11±19,8 mg/L. Sur le plan thérapeutique, 96% des patients étaient sous carbonate de calcium, 11% sous 25 OH vitamine D, 55,5% sous 1 hydroxy-vitamine D3. La prévalence des calcifications valvulaires était de 15% avec une localisation valvulaire aortique dans 41,2% et valvulaire mitrale dans 41,2%. En analyse univariée, seule la durée d'hémodialyse semble être associée à la survenue des calcifications avec p = 0,09 proche du seuil de significativité. Conclusion La prévalence des calcifications valvulaires chez nos patients hémodialysés reste élevée même si elle parait relativement moindre comparée aux données de la littérature. Aucun facteur de risque connu n'est apparu significativement associé à ces calcifications. PMID:27642453

A series of substituted (2E)-3-(2-fluoro-4-phenoxyphenyl)-1-phenylprop-2-en-1-ones.

PubMed

Chopra, Deepak; Mohan, T P; Vishalakshi, B; Row, T N Guru

2007-12-01

In the molecular structures of a series of substituted chalcones, namely (2E)-3-(2-fluoro-4-phenoxyphenyl)-1-phenylprop-2-en-1-one, C21H15FO2, (I), (2E)-3-(2-fluoro-4-phenoxyphenyl)-1-(4-fluorophenyl)prop-2-en-1-one, C21H14F2O2, (II), (2E)-1-(4-chlorophenyl)-3-(2-fluoro-4-phenoxyphenyl)prop-2-en-1-one, C21H14ClFO2, (III), (2E)-3-(2-fluoro-4-phenoxyphenyl)-1-(4-methylphenyl)prop-2-en-1-one, C22H17FO2, (IV), and (2E)-3-(2-fluoro-4-phenoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one, C22H17FO3, (V), the configuration of the keto group with respect to the olefinic double bond is s-cis. The molecules pack utilizing weak C-H...O and C-H...pi intermolecular contacts. Identical packing motifs involving C-H...O interactions, forming both chains and dimers, along with C-H...pi dimers and pi-pi aromatic interactions are observed in the fluoro, chloro and methyl derivatives.

The Army’s Wireless Communications Programs

DTIC Science & Technology

2009-02-11

20Plans%20First%20AEHF% 20Launch%20Early%20Next%20Year&channel= awst .9 CBO Other Strategic Wireless Communications Programs The Army invests in a number...O N G R E SS O F T H E U N IT E D ST AT E S C O N G R E SSIO N A L B U D G E T O FFIC E W A SH IN G T O N , D C 20515

E6AP is Required for Human Papillomavirus type 16 E6 to Cause Cervical Cancer in Mice

PubMed Central

Shai, Anny; Pitot, Henry C.; Lambert, Paul F.

2010-01-01

High-risk human papillomaviruses cause certain anogenital and head and neck cancers. E6, one of three potent HPV oncogenes that contribute to the development of these malignancies, is a multifunctional protein with many biochemical activities. Among these activities are its ability to bind and inactivate the cellular tumor suppressor p53, induce expression of telomerase, and bind to various other proteins including Bak, E6BP1, E6TP1, and proteins that contain PDZ domains such as hScrib and hDlg. Many of these activities are thought to contribute to E6’s role in carcinogenesis. E6’s interaction with many of these cellular proteins, including p53, leads to their destabilization. This property is mediated at least in part through E6’s ability to recruit the ubiquitin ligase, E6AP into complexes with these cellular proteins resulting in their ubiquitin–mediated degradation by the proteasome. In this study, we address the requirement for E6AP in mediating E6's acute and oncogenic phenotypes, including induction of epithelial hyperplasia, abrogation of DNA damage response and induction of cervical cancer. Loss of E6AP had no discernable effect on E6's ability to induce hyperplasia or abrogate DNA damage responses, akin to what we had earlier observed in the mouse epidermis. Nevertheless, in cervical carcinogenesis studies, there was a complete loss of E6’s oncogenic potential in mice nulligenic for E6AP. Thus, E6AP is absolutely required for E6 to cause cervical cancer. PMID:20530688

Investigations in the ionosphere by means of Kosmos 378. N(h) profiles and the temperature of the F region according to ground-based and satellite measurements above Khabarovsk

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mirmovich, E.G.; Shapiro, B.S.

1975-01-01

Simultaneous satellite measurements of electron density N/sub s/ and temperature (T/sub e/)/sub s/ at a height h/sub s/ above an observatory and ground-based observations are used to compute the total vertical electron density profiles N(h) and estimate the temperature of the ionospheric plasma. Four close time intervals after sunset were selected for analysis.

Electrochemical latent redox ratiometric probes for real-time tracking and quantification of endogenous hydrogen sulfide production in living cells.

PubMed

Manibalan, Kesavan; Mani, Veerappan; Chang, Pu-Chieh; Huang, Chih-Hung; Huang, Sheng-Tung; Marchlewicz, Kasper; Neethirajan, Suresh

2017-10-15

Hydrogen sulfide (H 2 S) was discovered as a third gasotransmitter in biological systems and recent years have seen a growing interest to understand its physiological and pathological functions. However, one major limiting factor is the lack of robust sensors to quantitatively track its production in real-time. We described a facile electrochemical assay based on latent redox probe approach for highly specific and sensitive quantification in living cells. Two chemical probes, Azido Benzyl ferrocene carbamate (ABFC) and N-alkyl Azido Benzyl ferrocene carbamate (NABFC) composed of azide trigger group were designed. H 2 S molecules specifically triggered the release of reporters from probes and the current response was monitored using graphene oxide film modified electrode as transducer. The detection limits are 0.32µM (ABFC) and 0.076µM (NABFC) which are comparable to those of current sensitive methods. The probes are successful in the determination of H 2 S spiked in whole human blood, fetal bovine serum, and E. coli. The continuous monitoring and quantification of endogenous H 2 S production in E. coli were successfully accomplished. This work lays first step stone towards real-time electrochemical quantification of endogenous H 2 S in living cells, thus hold great promise in the analytical aspects of H 2 S. Copyright © 2017 Elsevier B.V. All rights reserved.

A Hybrid Approach for Fault Detection in Autonomous Physical Agents

DTIC Science & Technology

2014-05-01

r l e c c f t d f a d c r r r t m e o i m s f U m d o s a u v c o t c r c t a c u n b S...escription e a set of attrib d, heading, pi et of values for alue assigned to t i s 1 l m a o p a r tr l c tr w o t n data H & ow detection mode roach is...dete Note that any ch can be used t e an autonomou e SFDD

Study of the Surface Morphology of Thermally Annealed Copper Foils and Various Transfer Methods for Graphene

DTIC Science & Technology

2013-01-01

suggesting the doping effect which owes to the Pauli Exclusion Principle for electrons and holes where the phonon cannot decay into electron-hole pairs...2011, 11, 3519−3525. [7] Li, X. S.; Cai, W. W.; An, J. H.; Kim, S.; Nah, J.; Yang, D. X.; Piner, R. D.; Velamakanni, A.; Jung , I.; Tutuc, E.; et al...Wu, W.; Yu, O.; Yitamben, E. N.; Fisher, B.; Guest, J. R.; Chen, Y. P.; et al. ACS Nano 2011, 5, 3607−3613. [24] Li, X. S.; Cai, W. W.; Jung , I. H

Fotometria de grupos compactos de galáxias no infravermelho próximo

NASA Astrophysics Data System (ADS)

Brasileiro, F.; Mendes de Oliveira, C.

2003-08-01

Apresentamos medidas nas bandas J, H e K de cerca de 90 galáxias em 34 grupos compactos. Através da combinação dos novos dados, com dados obtidos na literatura para a banda B, investigamos como as luminosidades, cores, tamanhos e massas das galáxias em grupos compactos foram afetadas por processos dinâmicos, e como essas diferem de galáxias em ambientes menos densos. Uma comparação dos novos valores obtidos com aqueles listados no catálogo 2MASS, mostram que para 50 galáxias estudadas em comum, as diferenças nas magnitudes J, H e K estão dentro dos erros fotométricos. Através da construção dos diagramas de cor (J-H x H-K e B-H x J-K), percebemos que as galáxias em grupos compactos ocupam posições no diagrama diferentes das posições de galáxias em campo ou em aglomerados, sendo mais parecidas com as posições ocupadas por galáxias HII, ou com excesso de poeira, acreditamos que tal deslocamento é derivado do aumento da taxa de formação estelar.

PRMT7 induces epithelial-to-mesenchymal transition and promotes metastasis in breast cancer.

PubMed

Yao, Ruosi; Jiang, Hao; Ma, Yuhui; Wang, Liping; Wang, Lin; Du, Juan; Hou, Pingfu; Gao, Yanyan; Zhao, Li; Wang, Guannan; Zhang, Yu; Liu, Dong-Xu; Huang, Baiqu; Lu, Jun

2014-10-01

Epithelial-to-mesenchymal transition (EMT) enables metastasis. E-cadherin loss is a hallmark of EMT, but there remains an incomplete understanding of the epigenetics of this process. The protein arginine methyltransferase PRMT7 functions in various physiologic processes, including mRNA splicing, DNA repair, and neural differentiation, but its possible roles in cancer and metastasis have not been explored. In this report, we show that PRMT7 is expressed at higher levels in breast carcinoma cells and that elevated PRMT7 mediates EMT and metastasis. PRMT7 could inhibit the expression of E-cadherin by binding to its proximal promoter in a manner associated with altered histone methylation, specifically with elevated H4R3me2s and reduced H3K4me3, H3Ac, and H4Ac, which occurred at the E-cadherin promoter upon EMT induction. Moreover, PRMT7 interacted with YY1 and HDAC3 and was essential to link these proteins to the E-cadherin promoter. Silencing PRMT7 restored E-cadherin expression by repressing H4R3me2s and by increasing H3K4me3 and H4Ac, attenuating cell migration and invasion in MDA-MB-231 breast cancer cells. Overall, our results define PRMT7 as an inducer of breast cancer metastasis and present the opportunity for applying PRMT7-targeted therapeutics to treat highly invasive breast cancers. ©2014 American Association for Cancer Research.

Chemical and Bandgap Engineering in Monolayer Hexagonal Boron Nitride

PubMed Central

Ba, Kun; Jiang, Wei; Cheng, Jingxin; Bao, Jingxian; Xuan, Ningning; Sun, Yangye; Liu, Bing; Xie, Aozhen; Wu, Shiwei; Sun, Zhengzong

2017-01-01

Monolayer hexagonal boron nitride (h-BN) possesses a wide bandgap of ~6 eV. Trimming down the bandgap is technically attractive, yet poses remarkable challenges in chemistry. One strategy is to topological reform the h-BN’s hexagonal structure, which involves defects or grain boundaries (GBs) engineering in the basal plane. The other way is to invite foreign atoms, such as carbon, to forge bizarre hybrid structures like hetero-junctions or semiconducting h-BNC materials. Here we successfully developed a general chemical method to synthesize these different h-BN derivatives, showcasing how the chemical structure can be manipulated with or without a graphene precursor, and the bandgap be tuned to ~2 eV, only one third of the pristine one’s. PMID:28367992

Optoelectronics Research Center

DTIC Science & Technology

2012-01-03

Stone, A. Malcoci, R. E. Miles, and I . Camara Mayorga, Electron. Lett., 41, 128–129, (2005). 10S. D. Roh, T. S. Yeoh, R. B. Swint, A. E. Huber, C. Y...and K. A. Shore, Unlocking dynamical diversity, Wiley, 2005. 14F. Grillot, K. Veselinov, M. Gioannini, I . Montrosset, J. Even, R. Piron, E. Homeyer, S...Bimberg, IEEE J. Sel. Topics Quantum Electron., 8, pp. 984-991, (2002). 16M. A. Cataluna, D. I . Nikitichev, S. Mikroulis, H. Simos, C. Simos, C

Importance of projectile-target interactions in the triple differential cross sections for Low energy (e,2e) ionization of aligned H2

NASA Astrophysics Data System (ADS)

Ali, Esam; Madison, Don; Ren, X.; Dorn, A.; Ning, Chuangang

2014-10-01

Experimental and theoretical Triple Differential Cross Sections (TDCS) are presented for electron impact ionization-excitation of the 2 sσg state of H2 in the perpendicular plane. The excited 2 sσg state immediately dissociates and the alignment of the molecule is determined by detecting one of the fragments. Results are presented for three different alignments in the xy-plane (scattering plane is xz)-alignment along y-axis, x-axis, and 45° between the x- and y-axes for incident electron energies of 4, 10, and 25 eV and different scattered electron angles of 20° and 30° in the perpendicular plane. Theoretical M4DW (molecular 4-body distorted wave) results are compared to experimental data, and overall we found reasonably good agreement between experiment and theory. The Results show that (e,2e) cross sections for excitation-ionization depend strongly on the orientation of the H2 molecule.

Timely Diagnosis of Acute Kidney Injury Using Kinetic eGFR and the Creatinine Excretion to Production Ratio, E/eG - Creatinine Can Be Useful!

PubMed

Endre, Zoltán H; Pianta, Timothy J; Pickering, John W

2016-01-01

Post transplant repeated measurements of urine volume and serum creatinine (sCr) are used to assess kidney function. Under non-steady state conditions, repeated measurement of sCr allows calculation of the kinetic estimated GFR (KeGFR). Additional measurement of urinary creatinine allows the calculation of the creatinine excretion to (estimated) production ratio (E/eG). We hypothesized that post-transplant KeGFR and E/eG would predict delayed graft function (DGF), as early as 4 h and outperform a validated clinical model at 12 h. This was a retrospective analysis of prospectively acquired data in a study of 56 recipients of deceased-donor kidney transplant. We assessed predictive performance with the area under the receiver operator characteristic curve (AUC) and the added value to a clinical model with integrated discrimination improvement analysis. At 4 h, the AUC for E/eG was 0.87 (95% CI 0.77-0.96) and for KeGFR 0.69 (95% CI 0.56-0.83). Both E/eG and KeGFR improved the risk prediction of a clinical model for DGF by 32 and 18%, and for non-DGF by 17 and 10%, respectively. While E/eG had better predictive performance of DGF than KeGFR, KeGFR might also facilitate perioperative management including drug dosing after kidney transplantation. Together these measurements may facilitate the possibility of conducting trials of early intervention to ameliorate the adverse effects of ischaemia-reperfusion injury on long-term DGF. © 2016 S. Karger AG, Basel.

Stress and Thermal Stress Compensation in Quartz SAW Devices

DTIC Science & Technology

1991-08-01

Laboratoire De Physique Et Metrologie Des Oscillateurs E. Bigler, D. Hauden, S. Ballandras OTIC hELECTLE E P19 99f "j APPROVED FOR PUBLIC RELASE, DISTRIBUTION...ORGANIZATION NAME(S) AND ADDRE$S(ES) 8. PERFORMING ORGANIZATION Laboratoire De Physique Et Metrologie Des Oscillateurs REPORT NUMBER Center National de la

A Comparison Between Actual Parts Usage and Parts Usage Projected in Allowance Parts Lists for Forklift Vehicles

DTIC Science & Technology

1976-06-01

CM ^ 7 w 3m Eh E-" S Q CM ^O S >AW CM Q O O GQ O Eh UN OS on< Ph Eh go a: H HH...UNCO CM O O CM O O rH O-CO CM {>-NO <H ONCO-3" CM COcM O- UN rH H rH rH CM ** •• •* r 7 ) Eh O -faX W c/2s-sx<-Sr~^>MEHCO<C £xl <Z fa O S fa s fa s •• rH...4i J>VU v> \\f <u -Q X Pi rxcvi CM fM»M (Moi IMIM OJ !M(V P4 PM m 10 Z IP — up up •• CP • UP< 7 » •* WU« •• U»V> •• w» •• y»y% •• u» •• l/« ••

Solubility of carbon dioxide and hydrogen sulfide in aqueous N-methyldiethanolamine solutions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huttenhuis, P.J.G.; Agrawal, N.J.; Versteeg, G.F.

2009-04-15

In this work, 72 new experimental solubility data points for H{sub 2}S and CO{sub 2} mixtures in aqueous N-methyldiethanol amine (MDEA) solutions at different methane partial pressures (up to 69 bara) are presented. They are correlated using an electrolyte equation of state (E-EOS) thermodynamic model. This model has already been used to estimate the CO{sub 2} solubility in aqueous MDEA (Huttenhuis et al. Fluid Phase Equilib. 2008, 264, 99-112) and the H{sub 2}S solubility in aqueous MDEA (Huttenhuis et al. Int. J. Oil, Gas Coal Technol. 2008, 1, 399-424). Here, the model is further extended to predict the behavior ofmore » CO{sub 2} and H{sub 2}S when they are present simultaneously in aqueous MDEA. The application of an equation of state is a new development for this type of system, i.e., of acid-gas-amine systems. The molecular interactions are described by Schwarzentruber et al.'s modification of the Redlich-Kwong-Soave equation of state, with terms added to account for ionic interactions in the liquid phase. The model is used to describe acid-gas solubility data for the CO{sub 2}-H{sub 2}S-MDEA-H{sub 2}O system reported in the open literature and experimental data reported here for the CO{sub 2}-H{sub 2}S-MDEA-H{sub 2}O-CH{sub 4} system.« less

Molecular hydrogen and excitation in the HH 1-2 system

NASA Technical Reports Server (NTRS)

Noriega-Crespo, A.; Garnavich, P. M.

1994-01-01

We present a series of molecular hydrogen images of the Herbig-Haro 1-2 system in the 1-0 S(1) transition at 2.121 microns, with a spatial resolution of approximately 2 sec. The distribution of H2 is then compared with that of the excitation, given by the (S II) 6717+6731 to H-alpha line ratio. We find that most optical condensations in the HH 1-2 system, including the VLA 1 jet, have H2 counterparts. H2 emission is detected in most low excitation knots, as expected for low velocity shocks (50 km/s less than), but also in high excitation regions, like in HH 1F and HH 2A min. For these latter objects, the H2 emission could be due to the interaction of the preionizing flux, produced by 150-200 km/s shocks, with the surrounding interstellar matter, i.e., fluorescence. The lack fluorescent lines in the ultraviolet (UV), however, suggest a different mechanism. H2 is detected at the tip of the VLA 1 jet, where the knot morphology suggests the presence of a second bow shock. H2 is detected also SE of HH 2E and SW of HH 1F, in regions with known NH3 emission.

Consolidation Needed for Procurements of DoD H-60 Helicopter Spare Parts (REDACTED)

DTIC Science & Technology

2016-10-12

Information Act. Report No. DODIG-2017-002 O C T O B E R 1 2 , 2 0 1 6 Consolidation Needed for Procurements of DoD H -60 Helicopter Spare Parts I N T E G R...Brief Consolidation Needed for Procurements of DoD H -60 Helicopter Spare Parts October 12, 2016 Visit us at www.dodig.mil Objective We determined...whether DoD was effectively managing the procurement of H -60 helicopter ( H -60) spare parts. The Army, Navy, Air Force, and U.S. Special Operations

The Ashra Project

NASA Astrophysics Data System (ADS)

Sasaki, M.; Aita, Y.; Aoki, T.; Asaoka, Y.; Browder, T.; Chonan, T.; Dye, S.; Eguchi, M.; Fox, R.; Guillian, G.; Hamilton, J.; Kimura, T.; Kohta, N.; Kuze, H.; Learned, J.; Masuda, M.; Matsuno, S.; Morimoto, Y.; Noda, K.; Ogawa, S.; Okumura, A.; Olsen, S.; Shibuya, H.; Shinomiya, K.; Sugiyama, N.; Yamaguchi, Y.; Yasuda, M.; Varner, G.; Watanabe, Y.; Watanabe, Y.

Ashra (All-sky Survey High Resolution Air-shower detector) is a project to build an unconventional optical telescope complex that images very wide field of view, covering 80% of the sky, yet with the angle pixel resolution of 1.2 arcsin, sensitive to the blue to UV light with the use of image intensifier and CMOS technology. The project primarily aims to observe Cherenkov and fluorescence lights from the lateral and longitudinal developments of very-high energy cosmic rays in the atmosphere. It can also be used to monitor optical transients in the wide field of sky. In 2004 we built prototype telescopes to verify and develop techniques at Haleakala in Hawaii, needed for the development of the full-scale telescopes. Construction of the main detector station has begun at Mauna Loa on the Hawaii Island in the summer of 2005. The pilot observation data have been taken. We will present the project status, and expected scientific impacts on the observational objectives such as optical transients, unidentified TeV gamma- ray and PeV neutrino sources, and the propagation of EeV cosmic rays. The Ashra Collaboration: (a) ICRR, Univ. Tokyo (b) Univ. Hawaii Manoa (c) Univ. Hawaii Hilo (d)Ibaraki Univ. (e) Toho Univ. (f) Chiba Univ. (g) Tokyo Inst. Tech. (h) Nagoya Univ. Y. Aita.^a, T. Aoki^a, Y. Asaoka^a, T. Browder^b, T. Chonan^a, S. Dye^b, M. Eguchi^a, R. Fox^c, G. Guillian^b, J. Hamilton^c, T. Kimura^d, N. Kohta^e, H. Kuze^f, J. Learned^b, M. Masuda^g, S. Matsuno^b, Y. Morimoto^e, K. Noda^a, S. Ogawa^e, A. Okumura^a, S. Olsen^b, M. Sasaki^a, H. Shibuya^e, K. Shinomiya^f, N. Sugiyama^h, Y. Yamaguchi^f, M. Yasuda^g, G. Varner^b, Y. Watanabe^g, Y. Watanabe^e

Photolysis of low concentration H2S under UV/VUV irradiation emitted from microwave discharge electrodeless lamps.

PubMed

Xia, Lan-Yan; Gu, Ding-Hong; Tan, Jing; Dong, Wen-Bo; Hou, Hui-Qi

2008-04-01

The photolysis of simulating low concentration of hydrogen sulfide malodorous gas was studied under UV irradiation emitted by self-made microwave discharge electrodeless lamps (i.e. microwave UV electrodeless mercury lamp (185/253.7 nm) and iodine lamp (178.3/180.1/183/184.4/187.6/206.2 nm)). Experiments results showed that the removal efficiency (eta H2S) of hydrogen sulfide was decreased with increasing initial H2S concentration and increased slightly with gas residence time; H2S removal efficiency was decreased dramatically with enlarged pipe diameter. Under the experimental conditions with pipe diameter of 36 mm, gas flow rate of 0.42 standard l s(-1), eta H2S was 52% with initial H2S concentration of 19.5 mg m(-3) by microwave mercury lamp, the absolute removal amount (ARA) was 4.30 microg s(-1), and energy yield (EY) was 77.3 mg kW h(-1); eta H2S was 56% with initial H2S concentration of 18.9 mg m(-3) by microwave iodine lamp, the ARA was 4.48 microg s(-1), and the EY was 80.5mg kW h(-1). The main photolysis product was confirmed to be SO4(2-) with IC.

Observations of Near-Bottom Flow in a Wave-Dominated Nearshore Environment.

DTIC Science & Technology

1994-02-01

E 0 0 0 ~- X : (- 1.. pI m~ ffm ~o .pcr onf> ..... X • -- E X/• x,. "£ "*.. . .. . 0o 0 0 a c c ,(s0wO) (S/PH w) (SlUwo) . 7109 I 3 I Mean of LDV...1 I 8250 ASM X,ANDA #&HBF :REM 0000 OXXX ACCA 8260 ASM X,ANDB #&HBF :REM 0000 1XXX ACCB 8270 ASM X,STAB &H17 :REM /CS=0 3 8280 ASM X,STAA &H17 :REM

Egocentric Depth Judgements in Optical, See-Through Augmented Reality

DTIC Science & Technology

2007-06-01

Gabbard , and D. Hix, “An Augmented Reality System for Military Operations in Urban Terrain,” Proc. Inter- service/Industry Training, Simulation...Education Conf. (I/ITSEC ’02), 2002. [20] M.A. Livingston, J.E. Swan II, J.L. Gabbard , T.H. Höllerer, D. Hix, S.J. Julier, Y. Baillot, and D. Brown...J.E. Swan II, M.A. Livingston, H.S. Smallman, D. Brown, Y. Baillot, J.L. Gabbard , and D. Hix, “A Perceptual Matching Technique for Depth Judgements in

Characterization and Evolution of Salmonella CRISPR-Cas Systems

DTIC Science & Technology

2014-01-01

aeruginosa and Streptococcus pyogenes ( Cady et al., 2011; Deltcheva et al., 2011). In the former, CRISPR-Cas has been linked to the regulation of...Science 321, 960–964. Cady , K. C., White, A. S., Hammond, J. H., Abendroth, M. D., Karthikeyan, R. S., Lalitha, P., Zegans, M. E. & O’Toole, G. A...40, 5569–5576. Zegans, M. E., Wagner, J. C., Cady , K. C., Murphy, D. M., Hammond, J. H. & O’Toole, G. A. (2009). Interaction between bacteriophage

Seepage-Based Factor of Safety Analysis Using 3D Groundwater Simulation Results

DTIC Science & Technology

2014-08-01

Edris, and D . Richards. 2006. A first-principle, physics- based watershed model: WASH123D. In Watershed models, ed. V. P. Singh and D . K . Frevert...should be cited as follows: Cheng, H.-P., K . D . Winters, S. M. England, and R. E. Pickett. 2014. Factor of safety analysis using 3D groundwater...Journal of Dam Safety 11(3): 33–42. Pickett, R. E., K . D . Winters, H.-P. Cheng, and S. M. England. 2013. Herbert Hoover Dike (HHD) flow model. Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kawanaka, Norita; Ioka, Kunihito; Nojiri, Mihoko M., E-mail: norita.kawanaka@kek.j

We investigate the observed spectrum of cosmic ray electrons and positrons from astrophysical sources, especially pulsars, and the physical processes for making the spectrum spiky or smooth via continuous and multiple electron/positron injections. We find that (1) the average electron spectrum predicted from nearby pulsars is consistent with PAMELA, Fermi, and H.E.S.S. data. However, the ATIC/PPB-BETS peak around 500 GeV is hard to produce by the sum of multiple pulsar contributions and requires a single (or a few) energetic pulsar(s). (2) A continuous injection produces a broad peak and a high-energy tail above the peak, which can constrain the sourcemore » duration ({approx}<10{sup 5} years with the current data). (3) The H.E.S.S. data in the TeV range suggest that young sources with age less than {approx}6 x 10{sup 4} years are less energetic than {approx}10{sup 48} erg. (4) We also expect a large dispersion in the TeV spectrum due to the small number of sources that may cause the high-energy cutoff inferred by H.E.S.S. and potentially provide a smoking gun for the astrophysical origin. These spectral diagnostics can be refined in the near future by the CALET experiments to discriminate different astrophysical and dark matter origins.« less

NO, hydrogen sulfide does not come first during tomato response to high salinity.

PubMed

da-Silva, Cristiane J; Mollica, Débora C F; Vicente, Mateus H; Peres, Lázaro E P; Modolo, Luzia V

2018-06-01

High salinity greatly impacts agriculture, particularly in tomato (Solanum lycopersicum), a crop that is a model to study this abiotic stress. This work investigated whether hydrogen sulfide (H 2 S) acts upstream or downstream of nitric oxide (NO) in the signaling cascade during tomato response to salt stress. An NO-donor incremented H 2 S levels by 12-18.9% while an H 2 S-donor yielded 10% more NO in roots. The NO accumulated in roots one-hour after NaCl treatment while H 2 S accumulation started two-hour later. The NO stimulated H 2 S accumulation in roots/leaves, but not the opposite (i.e H 2 S was unable to stimulate NO accumulation) two-hour post NaCl treatment. Also, NO accumulation was accompanied by an increment of transcript levels of genes that encode for H 2 S-synthesizing enzymes. Our results indicate that H 2 S acts downstream of NO in the mitigation of oxidative stress, which helps tomato plants to tolerate high salinity. Copyright © 2017 Elsevier Inc. All rights reserved.

Fabrication of Metamaterials by Drawing Techniques

DTIC Science & Technology

2011-03-03

Rill, M. Thiel, E. Müller, S. Essig, A. Frölich, G. von Freymann, S. Linden, D. Gerthsen, H. Hahn, K. Busch and M. Wegener, “Transition between...characterization and homogenization of nanostructured metamaterials,” J. Opt. 13, 013001 (2011). 25. L. H. Sperling , Introduction to physical polymer

Integrated Immunotherapy for Breast Cancer

DTIC Science & Technology

2016-09-01

May 1, 1998). 54. E. Hidalgo et al., The response of T cells to interleukin-6 is differentially regulated by the microenvironment of the rheumatoid ...synovial fluid and tissue. Arthritis and rheumatism 63, 3284 (Nov, 2011). 55. H. H. Oberg, D. Wesch, S. Grussel, S. Rose-John, D. Kabelitz

DEVELOPMENTAL TOXICITY EVALUATION OF WATER FROM ALTERNATIVE DISINFECTION SCENARIOS

EPA Science Inventory

NAROTSKY1, M.G., D.S. BEST1, E.H. ROGERS1, A. McDONALD1, Y.M. SEY1, E.S. HUNTER III 1, L.K. TEUSCHLER2, R.J. MILTNER3, T.F. SPETH3, G. RICE2, K.M. SCHENCK3, S.D. RICHARDSON4, M.C. MARR5, and J.E. SIMMONS1. 1US Environmental Protection Agency (EPA), National Health and Environment...

Lactobacillus buchneri S-layer as carrier for an Ara h 2-derived peptide for peanut allergen-specific immunotherapy.

PubMed

Anzengruber, Julia; Bublin, Merima; Bönisch, Eva; Janesch, Bettina; Tscheppe, Angelika; Braun, Matthias L; Varga, Eva-Maria; Hafner, Christine; Breiteneder, Heimo; Schäffer, Christina

2017-05-01

Peanut allergy is an IgE-mediated severe hypersensitivity disorder. The lack of a treatment of this potentially fatal allergy has led to intensive research on vaccine development. Here, we describe the design and initial characterization of a carrier-bound peptide derived from the most potent peanut allergen, Ara h 2, as a candidate vaccine. Based on the adjuvant capability of bacterial surface (S-) layers, a fusion protein of the S-layer protein SlpB from Lactobacillus buchneri CD034 and the Ara h 2-derived peptide AH3a42 was produced. This peptide comprised immunodominant B-cell epitopes as well as one T cell epitope. The fusion protein SlpB-AH3a42 was expressed in E. coli, purified, and tested for its IgE binding capacity as well as for its ability to activate sensitized rat basophil leukemia (RBL) cells. The capacity of Ara h 2-specific IgG rabbit-antibodies raised against SlpB-AH3a42 or Ara h 2 to inhibit IgE-binding was determined by ELISA inhibition assays using sera of peanut allergic patients sensitized to Ara h 2. IgE specific to the SlpB-AH3a42 fusion protein was detected in 69% (25 of 36) of the sera. Despite the recognition by IgE, the SlpB-AH3a42 fusion protein was unable to induce β-hexosaminidase release from sensitized RBL cells at concentrations up to 100ng per ml. The inhibition of IgE-binding to the natural allergen observed after pre-incubation of the 20 sera with rabbit anti-SlpB-AH3a42 IgG was more than 30% for four sera, more than 20% for eight sera, and below 10% for eight sera. In comparison, anti-Ara h 2 rabbit IgG antibodies inhibited binding to Ara h 2 by 48% ±13.5%. Our data provide evidence for the feasibility of this novel approach towards the development of a peanut allergen peptide-based carrier-bound vaccine. Our experiments further indicate that more than one allergen-peptide will be needed to induce a broader protection of patients allergic to Ara h 2. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Reaction mechanism of guanidinoacetate methyltransferase, concerted or step-wise.

PubMed

Zhang, Xiaodong; Bruice, Thomas C

2006-10-31

We describe a quantum mechanics/molecular mechanics investigation of the guanidinoacetate methyltransferase catalyzed reaction, which shows that proton transfer from guanidinoacetate (GAA) to Asp-134 and methyl transfer from S-adenosyl-L-methionine (AdoMet) to GAA are concerted. By self-consistent-charge density functional tight binding/molecular mechanics, the bond lengths in the concerted mechanism's transition state are 1.26 A for both the OD1 (Asp-134)-H(E) (GAA) and H(E) (GAA)-N(E) (GAA) bonds, and 2.47 and 2.03 A for the S8 (AdoMet)-C9 (AdoMet) and C9 (AdoMet)-N(E) (GAA) bonds, respectively. The potential-energy barrier (DeltaE++) determined by single-point B3LYP/6-31+G*//MM is 18.9 kcal/mol. The contributions of the entropy (-TDeltaS++) and zero-point energy corrections Delta(ZPE)++ by normal mode analysis are 2.3 kcal/mol and -1.7 kcal/mol, respectively. Thus, the activation enthalpy of this concerted mechanism is predicted to be DeltaH++ = DeltaE++ plus Delta(ZPE)++ = 17.2 kcal/mol. The calculated free-energy barrier for the concerted mechanism is DeltaG++ = 19.5 kcal/mol, which is in excellent agreement with the value of 19.0 kcal/mol calculated from the experimental rate constant (3.8 +/- 0.2.min(-1)).

Supersaturated Self-Assembled Charge-Selective Interfacial Layers for Organic Solar Cells

DTIC Science & Technology

2014-11-24

N. E.; Ratcliff, E. L.; Jenkins, J. L.; Armstrong, N. R.; Giordano, A. J.; Hotchkiss, P. J.; Marder, S. R.; Campbell, C. T.; Ginger , D. S. J. Phys...H. X.; Schlenker, C. W.; Giordano, A. J.; Garcia, A.; Smith, O. L.; Olson, D. C.; Marder, S. R.; Ginger , D. S. J. Phys. Chem. Lett. 2013, 4, 4038

Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Dowd, Bing; Williams, Sarah; Wang, Hongxin

Isoprenoid biosynthesis is an important area for anti-infective drug development. One isoprenoid target described is (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate (HMBPP) reductase (IspH), which forms isopentenyl diphosphate and dimethylallyl diphosphate from HMBPP in a 2H + /2e - reduction. IspH contains a 4 Fe-4 S cluster, and in this work, we first investigated how small molecules bound to the cluster by using HYSCORE and NRVS spectroscopies. The results of these, as well as other structural and spectroscopic investigations, led to the conclusion that, in most cases, ligands bound to IspH 4 Fe-4 S clusters by η 1 coordination, forming tetrahedral geometries at themore » unique fourth Fe, ligand side chains preventing further ligand (e.g., H 2 O, O 2 ) binding. Based on these ideas, we used in silico methods to find drug-like inhibitors that might occupy the HMBPP substrate binding pocket and bind to Fe, leading to the discovery of a barbituric acid analogue with a K i value of ≈500 nm against Pseudomonas aeruginosa IspH.« less

Discovery of VHE γ-ray emission and multi-wavelength observations of the BL Lacertae object 1RXS J101015.9-311909

NASA Astrophysics Data System (ADS)

H.E.S.S. Collaboration; Abramowski, A.; Acero, F.; Aharonian, F.; Akhperjanian, A. G.; Anton, G.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker, J.; Bernlöhr, K.; Birsin, E.; Biteau, J.; Bochow, A.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Büsching, I.; Carrigan, S.; Casanova, S.; Cerruti, M.; Chadwick, P. M.; Charbonnier, A.; Chaves, R. C. G.; Cheesebrough, A.; Cologna, G.; Conrad, J.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; Dickinson, H. J.; Djannati-Ataï, A.; Domainko, W.; Drury, L. O'C.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Egberts, K.; Eger, P.; Espigat, P.; Fallon, L.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gallant, Y. A.; Gast, H.; Gérard, L.; Gerbig, D.; Giebels, B.; Glicenstein, J. F.; Glück, B.; Göring, D.; Häffner, S.; Hague, J. D.; Hahn, J.; Hampf, D.; Harris, J.; Hauser, M.; Heinz, S.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; de Jager, O. C.; Jahn, C.; Jamrozy, M.; Jung, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Keogh, D.; Khélifi, B.; Klochkov, D.; Kluźniak, W.; Kneiske, T.; Komin, Nu.; Kosack, K.; Kossakowski, R.; Krayzel, F.; Laffon, H.; Lamanna, G.; Lenain, J.-P.; Lennarz, D.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Masbou, J.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Medina, M. C.; Méhault, J.; Moderski, R.; Mohamed, M.; Moulin, E.; Naumann, C. L.; Naumann-Godo, M.; de Naurois, M.; Nedbal, D.; Nekrassov, D.; Nguyen, N.; Nicholas, B.; Niemiec, J.; Nolan, S. J.; Ohm, S.; de Oña Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raue, M.; Rayner, S. M.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Ripken, J.; Rob, L.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sheidaei, F.; Skilton, J. L.; Sol, H.; Spengler, G.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Szostek, A.; Tavernet, J.-P.; Terrier, R.; Tluczykont, M.; Valerius, K.; van Eldik, C.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Völk, H. J.; Volpe, F.; Vorobiov, S.; Vorster, M.; Wagner, S. J.; Ward, M.; White, R.; Wierzcholska, A.; Zacharias, M.; Zajczyk, A.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.

2012-06-01

1RXS J101015.9-311909 is a galaxy located at a redshift of z=0.14 hosting an active nucleus (called AGN) belonging to the class of bright BL Lac objects. Observations at high (HE, E > 100 MeV) and very high (VHE, E > 100 GeV) energies provide insights into the origin of very energetic particles present in such sources and the radiation processes at work. We report on results from VHE observations performed between 2006 and 2010 with the H.E.S.S. instrument, an array of four imaging atmospheric Cherenkov telescopes. H.E.S.S. data have been analysed with enhanced analysis methods, making the detection of faint sources more significant. VHE emission at a position coincident with 1RXS J101015.9-311909 is detected with H.E.S.S. for the first time. In a total good-quality livetime of about 49 h, we measure 263 excess counts, corresponding to a significance of 7.1 standard deviations. The photon spectrum above 0.2 TeV can be described by a power-law with a photon index of Γ = 3.08 ± 0.42stat ± 0.20sys. The integral flux above 0.2 TeV is about 0.8% of the flux of the Crab nebula and shows no significant variability over the time reported. In addition, public Fermi/LAT data are analysed to search for high energy emission from the source. The Fermi/LAT HE emission in the 100 MeV to 200 GeV energy range is significant at 8.3 standard deviations in the chosen 25-month dataset. UV and X-ray contemporaneous observations with the Swift satellite in May 2007 are also reported, together with optical observations performed with the atom telescope located at the H.E.S.S. site. Swift observations reveal an absorbed X-ray flux of F(0.3-7) keV = 1.04+0.04-0.05 × 10-11 erg cm-2 s-1 in the 0.3-7 keV range. Finally, all the available data are used to study the multi-wavelength properties of the source. The spectral energy distribution (SED) can be reproduced using a simple one-zone Synchrotron Self Compton (SSC) model with emission from a region with a Doppler factor of 30 and a magnetic field between 0.025 and 0.16 G. These parameters are similar to those obtained for other sources of this type.

Behavior of the E-E' Bonds (E, E' = S and Se) in Glutathione Disulfide and Derivatives Elucidated by Quantum Chemical Calculations with the Quantum Theory of Atoms-in-Molecules Approach.

PubMed

Hayashi, Satoko; Tsubomoto, Yutaka; Nakanishi, Waro

2018-02-17

The nature of the E-E' bonds (E, E' = S and Se) in glutathione disulfide ( 1 ) and derivatives 2 - 3 , respectively, was elucidated by applying quantum theory of atoms-in-molecules (QTAIM) dual functional analysis (QTAIM-DFA), to clarify the basic contribution of E-E' in the biological redox process, such as the glutathione peroxidase process. Five most stable conformers a - e were obtained, after applying the Monte-Carlo method then structural optimizations. In QTAIM-DFA, total electron energy densities H b ( r c ) are plotted versus H b ( r c ) - V b ( r c )/2 at bond critical points (BCPs), where V b ( r c ) are potential energy densities at BCPs. Data from the fully optimized structures correspond to the static nature. Those containing perturbed structures around the fully optimized one in the plot represent the dynamic nature of interactions. The behavior of E-E' was examined carefully. Whereas E-E' in 1a - 3e were all predicted to have the weak covalent nature of the shared shell interactions, two different types of S-S were detected in 1 , depending on the conformational properties. Contributions from the intramolecular non-covalent interactions to stabilize the conformers were evaluated. An inverse relationship was observed between the stability of a conformer and the strength of E-E' in the conformer, of which reason was discussed.

Evaluation of Stress Corrosion Resistance Properties of 15CrMoR(H) in H2S Environment

NASA Astrophysics Data System (ADS)

Zhang, Yiliang; Wang, Jing; Wu, Mingyao; Li, Shurui; Liu, Wenbin

To evaluate the hydrogen resistant properties of the 15CrMoR(H) with new smelting process, according to NACE and National Standards, three tests including NACE standard tensile test, NACE standard bent-beam test and hydrogen induced cracking test are executed in saturated hydrogen sulfide(H2S) environment. Stress-life mathematical model of this material is given by analyzing and fitting the results of tensile test. Test results show that the threshold sth of tensile test is 0.7R eL(252MPa); the threshold nominal stress SC of bent-beam is higher than 4.5 R eL (1620MPa); for HIC test, the crack length rate CLR is 4.40%, the crack thickness rate CTR is 0.87% and the crack sensitive rate CSR is 0.04%. Compare with EFC standard, the safety margin of HIC test is 3.4, 3.4 and 37.5 times respectively. All the experimental results show that the new 15CrMoR(H) material has excellent H2S environmental cracking resistance properties.

Management: Department of the Army Productivity Improvement Program

DTIC Science & Technology

1982-08-01

VEPs will submit semi-annually to HQDA ( DACA -MP) WASH DC 20310 a statistical summary of VE actions (RCS DD- I&L (SA&A) 1138) in the format shown in...A r m y c o m m a n d s / s e p a r a t e a g e n c i e s w i l l furnish one copy of each to the Comptrol- ler of the Army, HQDA, ATTN: DACA - MP...d e d C h a n g e s t o P u b l i c a t i o n s a n d Blank Forms) direct to HQDA ( DACA - RPM) WASH DC 20310. D i s t r i b u t i o n . A c t i v e A

Electron Energy Deposition in Atomic Oxygen

DTIC Science & Technology

1986-12-31

the parametric fits developed by Jackman et al^ where the cross section is expressed as ij -14 6.5x10 Cf ij ( 1 -¥~ n 4L ^ ’ij (7) and the...Res. 72, 3967 (1967). 4. H.S. Porter, C.H. Jackman and A.E.S. Green, J. Chem. Phys. 65, 154 (1976) and references therein. 5. P.M. Banks, C.R...1966). 28. S.P. Roundtree and R.J.W. Henry, Phys. Rev. A6, 2106 (1972). 29. T. Sawada and P.S. Ganas, Phys. Rev. A7, 617 (1973). 30. C.H. Jackman

Nano-Electro-Mechanical (NEM) Relay Devices and Technology for Ultra-Low Energy Digital Integrated Circuits

DTIC Science & Technology

2013-05-01

number. 1. REPORT DATE 01 MAY 2013 2. REPORT TYPE 3. DATES COVERED 00-00- 2013 to 00-00- 2013 4. TITLE AND SUBTITLE Nano-Electro-Mechanical (NEM...18 Copyright © 2013 , by the author( s ). All rights reserved. Permission to make digital or hard copies of all or part of this work for personal or...E. Ismail, S .-H. Lo, G. A. Sai- Halasz, R . G. Viswanathan, H.-J. C. Wann, S . J. Wind, and H.- S . Wong, “CMOS scaling into the nanometer regime

Modifications of the Relation Between Cosmic Ray Ionization Rate ζ and H_{3}^{+} Column Density in the Central Molecular Zone of the Galactic Center

NASA Astrophysics Data System (ADS)

Oka, Takeshi

2017-06-01

In deriving the simple formula, ζL=2k_eN(H_{3}^{+})(n_C/n_H)_SVR/f(H_{2}), used to estimate cosmic ray H_{2} ionization rate ζ from observed H_3^+ column density N(H_3^+) in the Central Molecular Zone (CMZ) of the Galactic center (GC), the following two effects were neglected: (1) the charge exchange reaction H_2^+ + H → H_2 + H^+ which significantly reduces H_3^+ production rate if the fraction of molecular hydrogen f(H_2) is much lower than 1, and (2) the production of electrons from ionization of H_2 and H which greatly increases the H_3^+ destruction rate if ζ is much higher than 10^{-15} s^{-1}. (Only electrons from VUV first ionization of C atoms had been considered). Recent more extensive analysis using the Meudon PDR code by Le Petit et al. has indicated that these effects are not negligible in the CMZ. While an extensive chemical model calculation is beyond the scope of our analysis, we have attempted to use our simple model considering only hydrogenic species and electrons to take these two effects into account. When (1) is introduced, the rate of H_3^+ production is approximated to be ζn_H[f(H_2)]^2, which is ˜ 3 times lower than the previous value for f(H_2) = 0.6 reported by Le Petit et al.^{c} When (2) is taken into account, the electron number density is approximated to be n_e = n_CR + ζn_H/[2k_en(H_3^+)] where the first and second term represents electrons from the C atoms and those from H_2 and H, respectively. The first term (in which R represents the increase of metallicity from the solar vicinity to the GC, R ≥ 3) has the electron fraction x_e = 5 × 10^{-4} and the second term becomes significant at ζ ˜ 10^{-15} s^{-1}. This introduces a non-linearity between ζ and N(H_3^+) and the latter reaches a maximum at ζ ˜ 10^{-14} s^{-1} and decreases as ζ increases further. Application of the results to the observed N(H_3^+) will be discussed. Oka, T., Geballe, T. R., Goto, M., Usuda, T., McCall, B. J. 2005, ApJ, 632, 882 Indriolo, N., McCall, B. J. 2012, ApJ, 745:91 Le Petit, F., Ruaud, M., Bron, E., Godard, B., Roueff, E., Languignon, D., Le Bourlot, J. 2016, A&A, 585, A105 Oka, T. 2013, Chem. Rev. 113, 8738

Compendium of GAO’s Views on the Cost Saving Proposals of the Grace Commission. Volume 2. Individual Issue Analyses

DTIC Science & Technology

1985-02-19

CONITACT John R. Cherbini 275-9487 347 USAF 8: CONSOLIDATION AND COORDINATION OF AIR FORCE RESERVE AND AIR NATIONAL GUARD ACTIVITIES I. PPSSCC ISSUE... nowO O rAC-N’ In r-i.-l 41 E-l Z- - - U) E-4 z E- rz: E- 2 -4o w . U: >4 w~Q~ En~ o w o wE1W nH ( 14 0 uz m- H-Z U)PPz >4 W~0 E- E- W u w z U w 4ZE4E u

Department of the Navy Fiscal Year (FY) 2000/2001 Biennial Budget Estimates, Justification of Estimates, February 1999 Research, Development, Test & Evaluation, Navy Budget Activity 6.

DTIC Science & Technology

1999-02-01

g o o rd-H S 4-1 O M o id o ■H fi u a-H CDrH •H tn Q H >i fc ftU ■H i tn O o g o a o) o „ fi-H Ä-0 - $ H * H 01 O H 4J 4J 0 u...CJ CO fi fi-H g E> Q \\ fi S fi 1 <D,fi T) CDrH ^ Id W rH CO * o • _ Q o H O fi co „, <" •H O 4-1 x! o> fi JJ (D a o 0 >H in i

Thermo-labile stability of sigmaH (Spo0H) in temperature-sensitive spo0H mutants of Bacillus subtilis can be suppressed by mutations in RNA polymerase beta subunit.

PubMed

Ohashi, Y; Sugimaru, K; Nanamiya, H; Sebata, T; Asai, K; Yoshikawa, H; Kawamura, F

1999-03-18

We isolated novel temperature-sensitive mutants of spo0H, spo0H1 and spo0H5, having E61K and G30E amino-acid substitutions within the sigmaH protein, respectively, and located in the highly conserved region, "2", among prokaryotic sigma factors that participates in binding to core enzyme of RNA polymerase. These mutants showed a sporulation-deficient phenotype at 43 degrees C. Moreover, we successfully isolated suppressor mutants that were spontaneously generated from the spo0H mutants. Our genetic analysis of these suppressor mutations revealed that the suppressor mutations are within the rpoB gene coding for the beta subunit of RNA polymerase. The mutations caused single amino-acid substitutions, E857A and P1055S, in rpoB18 and rpoB532 mutants that were generated from spo0H1 and spo0H5, respectively. Whereas the sigmaH-dependent expression of a spo0A-bgaB fusion was greatly reduced in both spo0H mutants, their expression was partially restored in the suppressor mutants at 43 degrees C. Western blot analysis showed that the level of sigmaH protein in the wild type increased between T0 and T2 and decreased after T3, while the level of sigmaH protein in spo0H mutants was greatly reduced throughout growth, indicating that the mutant sigmaH proteins were rapidly degraded by some unknown proteolytic enzyme(s). The analysis of the half-life of sigmaH protein showed that the short life of sigmaH in spo0H mutants is prolonged in the suppressor mutants. These findings suggest that, at least to some extent, the process of E-sigmaH formation may be involved in stabilization of sigmaH at the onset of sporulation.

Mixed-Signal Electronics Technology for Space (MSETS)

DTIC Science & Technology

2006-02-16

N A L P R O C E S S IN G (IN TE R P O LA TO R ) (D E LT A _S IG M A ) SCR Figure 1: Schematic representation of...Meeting on Electrical Performance of Electronic Packaging, pp 128-131, Oct. 1998 [8] M . Rickelt, H.- M . Rein and E . Rose, “ Influence of Impact... Embabi , J. Pineda de Gyvez, D.J. Allstot and E . Sanchez- Sinencio, “A capacitor cross-coupled common-gate low noise amplifier,” IEEE Trans. on

A Combined Adaptive Tabu Search and Set Partitioning Approach for the Crew Scheduling Problem with an Air Tanker Crew Application

DTIC Science & Technology

2002-08-15

Agency Name(s) and Address(es) Maj Juan Vasquez AFOSR/NM 801 N. Randolph St., Rm 732 Arlington, VA 22203-1977 Sponsor/Monitor’s Acronym(s) Sponsor... Gelman , E., Patty, B., and R. Tanga. 1991. Recent Advances in Crew-Pairing Optimization at American Airlines, Interfaces, 21(1):62-74. Baker, E.K...Operations Research, 25(11):887-894. Chu, H.D., Gelman , E., and E.L. Johnson. 1997. Solving Large Scale Crew Scheduling Problems, European

Reactions of ferric hemoglobin and myoglobin with hydrogen sulfide under physiological conditions.

PubMed

Jensen, Birgitte; Fago, Angela

2018-05-01

Ferric hemoglobin (metHb) and myoglobin (metMb), present at low levels in vivo, have been recently found to oxidize hydrogen sulfide (H 2 S) in excess, thus potentially contributing to removal of toxic H 2 S in blood and heart, respectively. Here, we present a kinetic and thermodynamic study of the reaction of metHb and metMb with H 2 S under physiological conditions, i.e. at low H 2 S concentrations and with protein in excess of H 2 S. We show here that both proteins react with sub-stoichiometric H 2 S:heme ratios following two processes: a fast reversible binding of H 2 S to ferric heme that prevails at high H 2 S and a slow heme reduction to the ferrous state that prevails at low H 2 S. While these two processes are fast for metMb, H 2 S-induced heme reduction is slow for metHb and the metHb-H 2 S complex once formed is therefore relatively stable. We find that metHb binds H 2 S reversibly and cooperatively with a pH-dependent ligand affinity that is within the physiological range of H 2 S concentrations found in blood. Stopped-flow kinetics show identical association rate constants for H 2 S at varying pH, demonstrating that H 2 S and not HS - enters the ferric heme pocket. Dissociation rates of the metHb-H 2 S complex increase when decreasing pH, consistent with the pH-dependent affinity. Taken together, these data are consistent with a novel biological role of metHb as a H 2 S carrier in the blood, in parallel with the oxygen carrier function of the much more abundant ferrous Hb. In contrast, metMb in the heart could participate to redox-signaling involving H 2 S. Copyright © 2018 Elsevier Inc. All rights reserved.

The study of electronic structure and properties of silicene for gas sensor application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wella, Sasfan A.; Syaputra, Marhamni; Wungu, Triati D. K., E-mail: triati@fi.itb.ac.id

2016-03-11

In this study, we investigated the adsorption of gas molecules (H{sub 2}S, CO) on pristine silicene using first principles calculation. The structure, electronic properties, and adsorption energy of H{sub 2}S,CO/silicene are discussed thoroughly. We found that the pristine silicenewith low buckling structure is the most stable as compared with planar and high buckling structures. Silicene was able to detect a gas molecule which can be observed according tothe density of states analysis. Though a gas molecule adsorbed weakly, the electronic properties of the low buckling pristine silicene changed from semi-metal (zero band gap) to semiconductor. The adsorption energy of H{submore » 2}S and CO on silicene is 0.075 eV and 0.06 eV, respectively.« less

Three-body Coulomb systems using generalized angular-momentum S states

NASA Technical Reports Server (NTRS)

Whitten, R. C.; Sims, J. S.

1974-01-01

An expansion of the three-body Coulomb potential in generalized angular-momentum eigenfunctions developed earlier by one of the authors is used to compute energy eigenvalues and eigenfunctions of bound S states of three-body Coulomb systems. The results for He, H(-), e(-)e(+)e(-), and pmu(-)p are compared with the results of other computational approaches.

TRANEXAMIC ACID ACTION ON LIVER REGENERATION AFTER PARTIAL HEPATECTOMY: EXPERIMENTAL MODEL IN RATS.

PubMed

Sobral, Felipe Antonio; Daga, Henrique; Rasera, Henrique Nogueira; Pinheiro, Matheus da Rocha; Cella, Igor Furlan; Morais, Igor Henrique; Marques, Luciana de Oliveira; Collaço, Luiz Martins

2016-01-01

Different lesions may affect the liver resulting in harmful stimuli. Some therapeutic procedures to treat those injuries depend on liver regeneration to increase functional capacity of this organ. Evaluate the effects of tranexamic acid on liver regeneration after partial hepatectomy in rats. 40 rats (Rattus norvegicus albinus, Rodentia mammalia) of Wistar-UP lineage were randomly divided into two groups named control (CT) and tranexamic acid (ATX), with 20 rats in each. Both groups were subdivided, according to liver regeneration time of 32 h or seven days after the rats had been operated. The organ regeneration was evaluated through weight and histology, stained with HE and PCNA. The average animal weight of ATX and CT 7 days groups before surgery were 411.2 g and 432.7 g, and 371.3 g and 392.9 g after the regeneration time, respectively. The average number of mitotic cells stained with HE for the ATX and CT 7 days groups were 33.7 and 32.6 mitosis, and 14.5 and 14.9 for the ATX and CT 32 h groups, respectively. When stained with proliferating cell nuclear antigen, the numbers of mitotic cells counted were 849.7 for the ATX 7 days, 301.8 for the CT 7 days groups, 814.2 for the ATX 32 hand 848.1 for the CT 32 h groups. Tranexamic acid was effective in liver regeneration, but in longer period after partial hepatectomy. Muitas são as injúrias que acometem o fígado e levam a estímulo lesivo. Alguns procedimentos terapêuticos para tratamento dessas lesões dependem da regeneração hepática para aumentar a sua capacidade funcional. Avaliar o efeito do ácido tranexâmico na regeneração hepática após hepatectomia parcial em ratos. Foram utilizados 40 ratos (Rattus norvegicus albinus, Rodentia mammalia) convencionais da linhagem Wistar-UP. Foram divididos aleatoriamente em dois grupos de 20: grupo controle (CT) e grupo ácido tranexâmico (ATX). Cada um deles foi divido em dois subgrupos para avaliar a regeneração hepática no tempo de 32 h e 7 dias do pós-operatório. A regeneração do órgão foi avaliada quanto ao peso e histologia, sendo esta última por hematoxilina-eosina e antígeno nuclear de proliferação celular. A média dos pesos dos animais dos grupos ATX 7 dias e CT 7 dias no pré-operatório foram de 411,2 g e 432,7 g, respectivamente, e após a regeneração foram de 371,3 g e 392,9 g. As médias das taxas de mitose coradas por HE dos dois grupos em 7 dias foram de 33,7 e 32,6 mitoses, respectivamente, e de 14,5 e 14,9 mitoses para os grupos ATX e CT 32 h. A contagem de células por antígeno nuclear de proliferação celular mostrou valores de 849,7 para o grupo ATX 7 dias e 301,8 para o CT 7 dias; 814,2 para o grupo ATX 32 h e 848,1 para o CT 32 h. O ácido tranexâmico mostrou-se efetivo na regeneração hepática somente em período mais longo de observação após hepatectomia parcial.

Comparison of the efficacy of a commercial inactivated influenza A/H1N1/pdm09 virus (pH1N1) vaccine and two experimental M2e-based vaccines against pH1N1 challenge in the growing pig model.

PubMed

Opriessnig, Tanja; Gauger, Phillip C; Gerber, Priscilla F; Castro, Alessandra M M G; Shen, Huigang; Murphy, Lita; Digard, Paul; Halbur, Patrick G; Xia, Ming; Jiang, Xi; Tan, Ming

2018-01-01

Swine influenza A viruses (IAV-S) found in North American pigs are diverse and the lack of cross-protection among heterologous strains is a concern. The objective of this study was to compare a commercial inactivated A/H1N1/pdm09 (pH1N1) vaccine and two novel subunit vaccines, using IAV M2 ectodomain (M2e) epitopes as antigens, in a growing pig model. Thirty-nine 2-week-old IAV negative pigs were randomly assigned to five groups and rooms. At 3 weeks of age and again at 5 weeks of age, pigs were vaccinated intranasally with an experimental subunit particle vaccine (NvParticle/M2e) or a subunit complex-based vaccine (NvComplex/M2e) or intramuscularly with a commercial inactivated vaccine (Inact/pH1N1). At 7 weeks of age, the pigs were challenged with pH1N1 virus or sham-inoculated. Necropsy was conducted 5 days post pH1N1 challenge (dpc). At the time of challenge one of the Inact/pH1N1 pigs had seroconverted based on IAV nucleoprotein-based ELISA, Inact/pH1N1 pigs had significantly higher pdm09H1N1 hemagglutination inhibition (HI) titers compared to all other groups, and M2e-specific IgG responses were detected in the NvParticle/M2e and the NvComplex/M2e pigs with significantly higher group means in the NvComplex/M2e group compared to SHAMVAC-NEG pigs. After challenge, nasal IAV RNA shedding was significantly reduced in Inact/pH1N1 pigs compared to all other pH1N1 infected groups and this group also had reduced IAV RNA in oral fluids. The macroscopic lung lesions were characterized by mild-to-severe, multifocal-to-diffuse, cranioventral dark purple consolidated areas typical of IAV infection and were similar for NvParticle/M2e, NvComplex/M2e and SHAMVAC-IAV pigs. Lesions were significantly less severe in the SHAMVAC-NEG and the Inact/pH1N1pigs. Under the conditions of this study, a commercial Inact/pH1N1 specific vaccine effectively protected pigs against homologous challenge as evidenced by reduced clinical signs, virus shedding in nasal secretions and oral fluids and reduced macroscopic and microscopic lesions whereas intranasal vaccination with experimental M2e epitope-based subunit vaccines did not. The results further highlight the importance using IAV-S type specific vaccines in pigs.

1H NMR spectra dataset and solid-state NMR data of cowpea (Vigna unguiculata).

PubMed

Alves Filho, Elenilson G; Silva, Lorena M A; Teofilo, Elizita M; Larsen, Flemming H; de Brito, Edy S

2017-04-01

In this article the NMR data from chemical shifts, coupling constants, and structures of all the characterized compounds were provided, beyond a complementary PCA evaluation for the corresponding manuscript (E.G. Alves Filho, L.M.A. Silva, E.M. Teofilo, F.H. Larsen, E.S. de Brito, 2017) [3]. In addition, a complementary assessment from solid-state NMR data was provided. For further chemometric analysis, numerical matrices from the raw 1 H NMR data were made available in Microsoft Excel workbook format (.xls).

Physical Characterization of Clostridium Botulinum Neurotoxin Genes

DTIC Science & Technology

1993-10-01

Acid Res. 14, 7809-78 12. 10 Fujii, N., Kimura, K., Murakami, T ., Indoh, I., Yashiki, T ., Tsuzuki, K., Yokosawa , N. & Oguma, K. (1990) Microbiol...from Clostridium spp. whose genomic DNA is of a high A+ T content (greater than 70% A+ T ), exhibit an extremely strong discrimination against all...BoNT/E, 4-12 Sathyamoorthy T T et al. (1985) H E L I H S L H G LE2 YES 5’-CACGAACTTATACATTCTCTACATGG-3’ 861-886 BoNT/E, 212-220 Wernars & T T A AT

Comparison of 99mTc-UBI 29-41, 99mTc-Ciprofloxacin, 99mTc-Ciprofloxacin dithiocarbamate and 111In-biotin for targeting experimental Staphylococcus aureus and Escherichia coli foreign-body infections: an ex-vivo study.

PubMed

Auletta, Sveva; Baldoni, Daniela; Varani, Michela; Galli, Filippo; Hajar, Iman A; Duatti, Adriano; Ferro-Flores, Guillermina; Trampuz, Andrej; Signore, Alberto

2017-08-28

Diagnosis of implant-associated infection is challenging. Several radiopharmaceuticals have been described but direct comparisons are limited. Here we compared in vitro and in an animal model 99mTc-UBI, 99mTc-Ciprofloxacin, 99mTcN-CiproCS2 and 111In-DTPA-biotin for targeting E. coli (ATCC 25922) and S. aureus (ATCC 43335). Stability controls were performed with the labelled radiopharmaceuticals during 6 h in saline and serum. The in vitro binding to viable or killed bacteria was evaluated at 37 °C and 4 °C. For in vivo studies, Teflon cages were subcutaneously implanted in mice, followed by percutaneous infection. Biodistribution of i.v. injected radiolabelled radiopharmaceuticals were evaluated during 24 h in cages and dissected tissues. Labelling efficiency of all radiopharmaceuticals ranged between 94% and 98%, with high stability both in saline and in human serum. In vitro binding assays displayed a rapid but poor bacterial binding for all tested agents. Similar binding kinetic occurred also with heat-killed and ethanol-killed bacteria. In the tissue cage model, infection was detected at different time points: 99mTc-UBI and 99mTcN-CiproCS2 showed higher infected cage/sterile cage ratio at 24 h for both E. coli and S. aureus; 99mTc-Ciprofloxacin at 24 h for both E. coli and at 4 h for S. aureus; 111In-DTPA-biotin accumulates faster in both E. coli and S. aureus infected cages. 99mTc-UBI, 99mTcN-CiproCS2 showed poor in vitro binding but good in vivo binding to E. coli only. 111In-DTPA-biotin showed poor in vitro binding but good in vivo binding to S. aureus and poor to E. coli. 99mTc-Ciprofloxacin showed poor in vitro binding but good in vivo binding to all tested bacteria. The mechanism of accumulation in infected sites remains to be elucidated.

Effects of the temperature and pressure on the electronic and optical properties of an exciton in GaAs/Ga1-xAlxAs quantum ring

NASA Astrophysics Data System (ADS)

El-Bakkari, K.; Sali, A.; Iqraoun, E.; Rezzouk, A.; Es-Sbai, N.; Ouazzani Jamil, M.

2018-06-01

Using a variational approach, we have calculated the binding energies (E1s,2sb) and interband emission energy (Eph) of an exciton confined in GaAs / Ga1 - x Alx As quantum rings (QRs) structures under effects of the temperature and pressure, in the effective mass approximation. We have taken into consideration the difference in the effective masses of the charge carriers in two materials, well and barrier. The results that we have obtained show clearly that E1s,2sb and Eph are influenced by the structure geometries of QR (height H, radial thickness Δ R and potential barrier), the temperature and pressure. Indeed, with a smaller geometric parameter, E1s,2sb and Eph become higher due to the improvement in confinement of the charge carriers. We have also observed that for a given value of the temperature, the pressure leads to an increasing of the E1s,2sb and Eph , and the latter quantities are decreasing with temperature. In addition, these variations of the E1s,2sb and Eph under the external perturbations are more remarkable in small H for fixed Δ R , and for larger Δ R for a given value of the H, because for the choice of a finite height of the barrier in the z direction and an infinite confinement in ρ direction.

Effects of sulfurization time and H{sub 2}S concentration on electrical properties of Cu{sub 2}ZnSnS{sub 4} films prepared by sol–gel method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Long, Bo; Cheng, Shuying, E-mail: sycheng@fzu.edu.cn; Jiangsu Collaborative Innovation Center of Photovolatic Science and Engineering, Changzhou 213164

2016-01-15

Highlights: • Cu{sub 2}ZnSnS{sub 4} (CZTS) films were prepared by sol–gel method following sulfurization. • The sulfurization time and H{sub 2}S concentration have the effects on the electrical properties. • The tin loss is increased with the increasing of the sulfurization time. • The secondary phases like ZnS make the electrical properties worse. • The CZTS films sulfurized at 5% H{sub 2}S for 90 min had the best electrical properties. - Abstract: Cu{sub 2}ZnSnS{sub 4} (CZTS) thin films have been successfully deposited by a sol–gel method and sulfurization process. The properties of the films were investigated by varying sulfurization timemore » and H{sub 2}S concentration. X-ray diffraction and Raman spectra analyses revealed the formation of CZTS films with a tetragonal type kesterite structure. With increasing the sulfurization time and H{sub 2}S concentration, the intensity of the kesterite (1 1 2) peak became sharper. The stoichiometric ratios of the CZTS films were different from the precursors, which was due to Sn loss during the sulfurization process. The electrical resistivity and mobility of the films increased while the carrier concentration decreased with increasing the sulfurization time. The CZTS thin films sulfurized at 5% H{sub 2}S concentration for 90 min had the best opto-electrical properties with E{sub g} of 1.41 eV, resistivity of 3.64 Ω cm, carrier concentration of 1.11 × 10{sup 18} cm{sup −3} and mobility of 1.54 cm{sup 2}/(V s) at room temperature for PV application.« less

A Possible Progenitor of the Interstellar Sulfide Bond: Rovibrational Characterization of the Hydrogen Disulfide Cation HSSH+

NASA Astrophysics Data System (ADS)

Fortenberry, Ryan C.; Francisco, Joseph S.

2018-03-01

{\\tilde{X}}2A\\prime\\prime S2H (HSS) has been observed very recently in the interstellar medium, specifically in the Horsehead nebula. The protonated form, S2H2 +, is believed to be a necessary intermediate in its creation in the gas phase in UV-irradiated regions. However, little is known about this radical cation. This work showcases that the trans-HSSH+ isomer is 0.12 eV lower in energy than the cis with a 1.05 eV upper limit to the torsional rotation barrier. Additionally, the vibrational frequencies and rotational constants for both structures are provided in full here for the first time. The cis isomer is likely the more detectable since it possesses a permanent dipole moment and has a high-intensity vibrational frequency for the antisymmetric H‑S‑S bend at 926 cm‑1 (10.8 μm), in the heart of the mid-IR spectral range. A third isomer, H2S‑S+ is also reported herein lying ∼0.9 eV in energy above trans-HSSH+. This isomer could play a role in the formation of S2H since it would be kinetically favored in the reaction of sulfur cations with hydrogen sulfide. Further assessment of this third, higher-energy isomer is left for future work.

12 CFR 226.18 - Content of disclosures.

Code of Federal Regulations, 2014 CFR

2014-01-01

... separately from other periodic payments disclosed in the table under this paragraph (s), outside the table... form of a table, with no more than five columns, with headings and format substantially similar to Model Clause H-4(E), H-4(F), H-4(G), or H-4(H) in Appendix H to this part. The table shall contain only...

12 CFR 226.18 - Content of disclosures.

Code of Federal Regulations, 2013 CFR

2013-01-01

... separately from other periodic payments disclosed in the table under this paragraph (s), outside the table... form of a table, with no more than five columns, with headings and format substantially similar to Model Clause H-4(E), H-4(F), H-4(G), or H-4(H) in Appendix H to this part. The table shall contain only...

Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement.

PubMed

Churcher, Ian; Williams, Susie; Kerrad, Sonia; Harrison, Timothy; Castro, José L; Shearman, Mark S; Lewis, Huw D; Clarke, Earl E; Wrigley, Jonathan D J; Beher, Dirk; Tang, Yui S; Liu, Wensheng

2003-06-05

Novel benzodiazepine-containing gamma-secretase inhibitors for potential use in Alzheimer's disease have been designed that incorporate a substituted hydrocinnamide C-3 side chain. A syn combination of alpha-alkyl or aryl and beta-hydroxy or hydroxymethyl substituents was shown to give highly potent compounds. In particular, (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)butyramide (34) demonstrated excellent in vitro potency (IC(50) = 0.06 nM). 34 could also be selectively methylated to give [(3)H]-28, which is of use in radioligand binding assays.

The metallization and superconductivity of dense hydrogen sulfide

NASA Astrophysics Data System (ADS)

Li, Yinwei; Hao, Jian; Liu, Hanyu; Li, Yanling; Ma, Yanming

2014-05-01

Hydrogen sulfide (H2S) is a prototype molecular system and a sister molecule of water (H2O). The phase diagram of solid H2S at high pressures remains largely unexplored arising from the challenges in dealing with the pressure-induced weakening of S-H bond and larger atomic core difference between H and S. Metallization is yet achieved for H2O, but it was observed for H2S above 96 GPa. However, the metallic structure of H2S remains elusive, greatly impeding the understanding of its metallicity and the potential superconductivity. We have performed an extensive structural study on solid H2S at pressure ranges of 10-200 GPa through an unbiased structure prediction method based on particle swarm optimization algorithm. Besides the findings of candidate structures for nonmetallic phases IV and V, we are able to establish stable metallic structures violating an earlier proposal of elemental decomposition into sulfur and hydrogen [R. Rousseau, M. Boero, M. Bernasconi, M. Parrinello, and K. Terakura, Phys. Rev. Lett. 85, 1254 (2000)]. Our study unravels a superconductive potential of metallic H2S with an estimated maximal transition temperature of ˜80 K at 160 GPa, higher than those predicted for most archetypal hydrogen-containing compounds (e.g., SiH4, GeH4, etc.).

Enzyme-assisted extraction and identification of antioxidative and α-amylase inhibitory peptides from Pinto beans (Phaseolus vulgaris cv. Pinto).

PubMed

Ngoh, Ying-Yuan; Gan, Chee-Yuen

2016-01-01

Antioxidant and α-amylase inhibitor peptides were successfully extracted from Pinto bean protein isolate (PBPI) using Protamex. A factorial design experiment was conducted and the effects of extraction time, pH and temperature were studied. pH 7.5, extraction time of 1h, S/E ratio of 10 (w/w) and temperature of 50 °C gave the highest antioxidant activities (i.e., ABTS scavenging activity (53.3%) and FRAP value (3.71 mM)), whereas pH 6.5 with the same extraction time, S/E ratio and temperature, gave the highest α-amylase inhibitory activity (57.5%). It was then fractioned using membrane ultrafiltration with molecular weight cutoffs of 100, 50, 30, 10 and 3 kDa. Peptide fraction <3 kDa, which exhibited the highest antioxidant activities (i.e., ABTS (42.2%) and FRAP (0.81 mM)) and α-amylase inhibitory activity (62.1%), was then subjected to LCMS and MS/MS analyses. Six sequences were identified for antioxidant peptides, whereas seven peptides for α-amylase inhibitor. Copyright © 2015 Elsevier Ltd. All rights reserved.