77 FR 30187 - Amendment of Class E Airspace; Rock Springs, WY

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-22

...-0131; Airspace Docket No. 12-ANM-2] Amendment of Class E Airspace; Rock Springs, WY AGENCY: Federal... Rock Springs-Sweetwater County Airport, Rock Springs, WY. Decommissioning of the Rock Springs Tactical... Rock Springs, WY (77 FR 11796). Interested parties were invited to participate in this rulemaking...

77 FR 11796 - Proposed Amendment of Class E Airspace; Rock Springs, WY

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-28

...-0131; Airspace Docket No. 12-ANM-2 Proposed Amendment of Class E Airspace; Rock Springs, WY AGENCY... action proposes to amend Class E airspace at Rock Springs-Sweetwater County Airport, Rock Springs, WY. Decommissioning of the Rock Springs Tactical Air Navigation System (TACAN) has made this action necessary for the...

High-field MRS in clinical drug development.

PubMed

Ross, Brian D

2013-07-01

Magnetic resonance spectroscopy (MRS) will continue to play an ever increasing role in drug discovery because MRS does readily define biomarkers for several hundreds of clinically distinct diseases. Published evidence based medicine (EBM) surveys, which generally conclude the opposite, are seriously flawed and do a disservice to the field of drug discovery. This article presents MRS and how it has guided several hundreds of practical human 'drug discovery' endeavors since its development. Specifically, the author looks at the process of 'reverse-translation' and its influence in the expansion of the number of preclinical drug discoveries from in vivo MRS. The author also provides a structured approach of eight criteria, including EBM acceptance, which could potentially re-open the field of MRS for productive exploration of existing and repurposed drugs and cost-effective drug-discovery. MRS-guided drug discovery is poised for future expansion. The cost of clinical trials has escalated and the use of biomarkers has become increasingly useful in improving patient selection for drug trials. Clinical MRS has uncovered a treasure-trove of novel biomarkers and clinical MRS itself has become better standardized and more widely available on 'routine' clinical MRI scanners. When combined with available new MRI sequences, MRS can provide a 'one stop shop' with multiple potential outcome measures for the disease and the drug in question.

EMRS Spring Meeting 2014 Symposium D: Phonons and fluctuations in low dimensional structures

NASA Astrophysics Data System (ADS)

2014-11-01

The E-MRS 2014 Spring meeting, held from 26-30th May 2014 in Lille included the Symposium D entitled ''Phonons and Fluctuations in Low Dimensional Structures'', the first edition of its kind. The symposium was organised in response to the increasing interest in the study of phonons in the context of advances in condensed matter physics, electronics, experimental methods and theory and, in particular, the transfer of energy across atomic interfaces and the propagation of energy in the nm-scale. Steering heat by light or vice versa and examining nano-scale energy conversion (as in thermoelectricity and harvesting e.g. in biological systems) are two aspects that share the underlying science of energy processes across atomic interfaces and energy propagation in the nanoscale and or in confined systems. The nanometer scale defies several of the bulk relationships as confinement of electrons and phonons, locality and non-equilibrium become increasingly important. The propagation of phonons as energy carriers impacts not only heat transfer, but also the very concept and handling of temperature in non-equilibrium and highly localised conditions. Much of the needed progress depends on the materials studied and this symposium targeted the interface material aspects as well as the emerging concepts to advance in this field. The symposium had its origins in a series of meetings and seminars including: (1) the first Phonon Engineering Workshop, funded by Catalan Institute for Research and Advanced Studies (ICREA), the then MICINN, the CNRS, VTT, and several EU projects, held in Saint Feliu de Guixols (Girona, Spain) from 24th to 27th of May 2010 with 65 participants from Europe, the USA and Japan; (2) the first Phonons and Fluctuations workshop, held in Paris on 8th and 9th November 2010, supported by French, Spanish and Finnish national projects and EU projects, attended by about 50 researchers; (3) the second Phonon and Fluctuations workshop, held in Paris on 8th and 9th

Mrs. Squandertime

NASA Astrophysics Data System (ADS)

Anstey, Josephine; Pape, Dave

2013-03-01

In this paper we discuss Mrs. Squandertime, a real-time, persistent simulation of a virtual character, her living room, and the view from her window, designed to be a wall-size, projected art installation. Through her large picture window, the eponymous Mrs. Squandertime watches the sea: boats, clouds, gulls, the tide going in and out, people on the sea wall. The hundreds of images that compose the view are drawn from historical printed sources. The program that assembles and animates these images is driven by weather, time, and tide data constantly updated from a real physical location. The character herself is rendered photographically in a series of slowly dissolving stills which correspond to the character's current behavior.

77 FR 9840 - Amendment of Class E Airspace; Colorado Springs, CO

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-21

...-1191; Airspace Docket No. 11-ANM-21] Amendment of Class E Airspace; Colorado Springs, CO AGENCY... airspace at City of Colorado Springs Municipal Airport, Colorado Springs, CO. Decommissioning of the Black... controlled airspace at Colorado Springs, CO (76 FR 70920). Interested parties were invited to participate in...

76 FR 70920 - Proposed Amendment of Class E Airspace; Colorado Springs, CO

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

...-1191; Airspace Docket No. 11-ANM-21] Proposed Amendment of Class E Airspace; Colorado Springs, CO...: This action proposes to amend Class E airspace at City of Colorado Springs Municipal Airport, Colorado Springs, CO. Decommissioning of the Black Forest Tactical Air Navigation System (TACAN) has made this...

78 FR 14911 - Amendment of Class E Airspace; Hot Springs, SD

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-08

...-0655; Airspace Docket No. 12-AGL-6] Amendment of Class E Airspace; Hot Springs, SD AGENCY: Federal... Springs, SD. Additional controlled airspace is necessary to accommodate new Area Navigation (RNAV) Standard Instrument Approach Procedures at Hot Springs Municipal Airport. The FAA is taking this action to...

An Integrated MRI and MRS Approach to Evaluation of Multiple Sclerosis with Cognitive Impairment

NASA Astrophysics Data System (ADS)

Liang, Zhengrong; Li, Lihong; Lu, Hongbing; Huang, Wei; Tudorica, Alina; Krupp, Lauren

Magnetic resonance imaging and spectroscopy (MRI/MRS) plays a unique role in multiple sclerosis (MS) evaluation, because of its ability to provide both high image contrast and significant chemical change among brain tissues. The image contrast renders the possibility of quantifying the tissue volumetric and texture variations, e.g., cerebral atrophy and progressing speed, reflecting the ongoing destructive pathologic processes. Any chemical change reflects an early sign of pathological alteration, e.g., decreased N-acetyl aspartate (NAA) in lesions and normal appearing white matter, related to axonal damage or dysfunction. Both MRI and MRS encounter partial volume (PV) effect, which compromises the quantitative capability, especially for MRS. This work aims to develop a statistical framework to segment the tissue mixtures inside each image element, eliminating theoretically the PV effect, and apply the framework to the evaluation of MS with cognitive impairment. The quantitative measures from MRI/MRS neuroimaging are strongly correlated with the qualitative neuropsychological scores of Brief Repeatable Battery (BRB) test on cognitive impairment, demonstrating the usefulness of the PV image segmentation framework in this clinically significant problem.

76 FR 5303 - Proposed Amendment of Class E Airspace; Carrizo Springs, Glass Ranch Airport, TX

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-31

...-0877; Airspace Docket No. 10-ASW-13] Proposed Amendment of Class E Airspace; Carrizo Springs, Glass... rulemaking (NPRM). SUMMARY: This action proposes to amend Class E airspace for the Carrizo Springs, Glass.... * * * * * ASW TX E5 Carrizo Springs, Glass Ranch Airport, TX [Amended] Carrizo Springs, Glass Ranch Airport, TX...

76 FR 22011 - Amendment of Class E Airspace; Carizzo Springs, Glass Ranch Airport, TX

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-20

...-0877; Airspace Docket No. 10-ASW-13] Amendment of Class E Airspace; Carizzo Springs, Glass Ranch... amends Class E airspace for the Carizzo Springs, Glass Ranch Airport, TX, airspace area, to accommodate... rulemaking to amend Class E airspace for the Carizzo Springs, Glass Ranch Airport, TX, airspace area...

PREFACE: Proceedings Symposium G of E-MRS Spring Meeting on Fundamentals and Technology of Multifunctional Oxide Thin Films

NASA Astrophysics Data System (ADS)

2010-07-01

Oxide materials exhibit a large variety of functional properties that are useful in a plethora of applications. Symposium G focused on oxide thin films that include dielectric or switching properties. Its program mirrored very well the strong worldwide search for high-K thin films for gate, memory, and on-chip capacitors, as well as the emerging field of functional thin films for MEMS. A complete session was devoted to the colossal effect of dielectric response in (Ca,Cu)TiO3, representing the major European research groups in this field. A comprehensive overview on this phenomenon was given by D Sinclair J Wolfman presented the latest results on CCTO thin films obtained by wafer scale pulsed laser deposition. A Loidl showed the analytical power of dielectric spectroscopy when covering the complete frequency range from 1-1012 Hz, i.e. from space charge to phonon contributions at the example of CCTO. Another session was devoted to applications in non-volatile memories, covering various effects including ferroelectric and resistive switching, the complex behavior of oxide tunnel junctions (H Kohlstedt), the possibility to manipulate the magnetic state of a 2d-electron gas by the polarization of an adjacent ferroelectric gate (I Stolitchnov). Latest advancements in ALD processing for high-K thin films in dynamic RAM were reported by S Ramanathan. The advancement of piezoelectric PZT thin film MEMS devices was well documented by outstanding talks on their developments in industry (M Klee, F Tyholdt), new possibilities in GHz filters (T Matshushima), advancements in sol-gel processing (B Tuttle, H Suzuki), and low temperature integration approaches by UV light curing (S Trolier-McKinstry). Recent advances in incipient ferroelectric thin films and nano composites for tunable capacitors in microwave applications were present by A Vorobiev and T Yamada. Integrated electro-optics is another field to be conquered by thin film structures. The impressive progress made in this

mrsFAST-Ultra: a compact, SNP-aware mapper for high performance sequencing applications.

PubMed

Hach, Faraz; Sarrafi, Iman; Hormozdiari, Farhad; Alkan, Can; Eichler, Evan E; Sahinalp, S Cenk

2014-07-01

High throughput sequencing (HTS) platforms generate unprecedented amounts of data that introduce challenges for processing and downstream analysis. While tools that report the 'best' mapping location of each read provide a fast way to process HTS data, they are not suitable for many types of downstream analysis such as structural variation detection, where it is important to report multiple mapping loci for each read. For this purpose we introduce mrsFAST-Ultra, a fast, cache oblivious, SNP-aware aligner that can handle the multi-mapping of HTS reads very efficiently. mrsFAST-Ultra improves mrsFAST, our first cache oblivious read aligner capable of handling multi-mapping reads, through new and compact index structures that reduce not only the overall memory usage but also the number of CPU operations per alignment. In fact the size of the index generated by mrsFAST-Ultra is 10 times smaller than that of mrsFAST. As importantly, mrsFAST-Ultra introduces new features such as being able to (i) obtain the best mapping loci for each read, and (ii) return all reads that have at most n mapping loci (within an error threshold), together with these loci, for any user specified n. Furthermore, mrsFAST-Ultra is SNP-aware, i.e. it can map reads to reference genome while discounting the mismatches that occur at common SNP locations provided by db-SNP; this significantly increases the number of reads that can be mapped to the reference genome. Notice that all of the above features are implemented within the index structure and are not simple post-processing steps and thus are performed highly efficiently. Finally, mrsFAST-Ultra utilizes multiple available cores and processors and can be tuned for various memory settings. Our results show that mrsFAST-Ultra is roughly five times faster than its predecessor mrsFAST. In comparison to newly enhanced popular tools such as Bowtie2, it is more sensitive (it can report 10 times or more mappings per read) and much faster (six times or

General Robert E. Lee (1807-70) and Philanthropist George Peabody (1795-1869) at White Sulphur Springs, West Virginia, July 23-Aug. 30, 1869.

ERIC Educational Resources Information Center

Parker, Franklin; Parker, Betty J.

This paper discusses the chance meeting at White Sulphur Springs (West Virginia) of two important public figures, Robert E. Lee and George Peabody, whose rare encounter marked a symbolic turn from Civil War bitterness toward reconciliation and the lifting power of education. The paper presents an overview of Lee's life and professional and…

Glutamate and Glutamine: A Review of In Vivo MRS in the Human Brain

PubMed Central

Ramadan, Saadallah; Lin, Alexander; Stanwell, Peter

2013-01-01

Our understanding of the roles that the amino acids glutamate (Glu) and glutamine (Gln) play in the mammalian central nervous system has increased rapidly in recent times. Many conditions are known to exhibit a disturbance in Glu-Gln equilibrium and the exact relationship between these changed conditions and these amino acids are not fully understood. This has led to increased interest in Glu/Gln quantitation in the human brain in an array of conditions (e.g. mental illness, tumor, neuro-degeneration) as well as in normal brain function. Accordingly, this review has been undertaken to describe the increasing number of in vivo techniques available to study Glu and Gln separately, or pooled as ‘Glx’. The present range of magnetic resonance spectroscopy (MRS) methods used to assess Glu and Gln, vary in approach, complexity and outcome, thus the focus of this review is on a description of MRS acquisition approaches, and an indication of relative utility of each technique rather than brain pathologies associated to Glu and/or Gln perturbation. Consequently, this review focuses particularly on (1) one-dimensional (1D) 1H MRS, (2) two-dimensional (2D) 1H MRS, and (3) 1D 13C MRS techniques. PMID:24123328

TRIAD Annual Spring Meeting (49th) Held in Huntsville, Alabama on May 27, 2010

DTIC Science & Technology

2010-05-27

Northrop Grumman Mission Systems Ms. Mitzi Whittenburg BAE Systems Presentations from the Spring TRIAD will be available to download 1-2 weeks...Ms. Mitzi Whittenburg, C.P.M., BAE Systems, Land & Armaments U.S. Combat Systems (USCS) u Ms. Chireda Gaither, CSC 2:50 pm - 3:00 pm CLOSING...REMARKS u Ms. Diane Dempsey, NDIA TRIAD Co-Chair, Meeting Chair Ms. Mitzi Whittenburg, CPM BAE Systems, Land & Armaments U.S. Combat Systems

Proton MRS in acute traumatic brain injury: role for glutamate/glutamine and choline for outcome prediction.

PubMed

Shutter, Lori; Tong, Karen A; Holshouser, Barbara A

2004-12-01

Proton magnetic resonance spectroscopy (MRS) is being used to evaluate individuals with acute traumatic brain injury and several studies have shown that changes in certain brain metabolites (N-acetylaspartate, choline) are associated with poor neurologic outcomes. The majority of previous MRS studies have been obtained relatively late after injury and none have examined the role of glutamate/ glutamine (Glx). We conducted a prospective MRS study of 42 severely injured adults to measure quantitative metabolite changes early (7 days) after injury in normal appearing brain. We used these findings to predict long-term neurologic outcome and to determine if MRS data alone or in combination with clinical outcome variables provided better prediction of long-term outcomes. We found that glutamate/glutamine (Glx) and choline (Cho) were significantly elevated in occipital gray and parietal white matter early after injury in patients with poor long-term (6-12-month) outcomes. Glx and Cho ratios predicted long-term outcome with 94% accuracy and when combined with the motor Glasgow Coma Scale score provided the highest predictive accuracy (97%). Somatosensory evoked potentials were not as accurate as MRS data in predicting outcome. Elevated Glx and Cho are more sensitive indicators of injury and predictors of poor outcome when spectroscopy is done early after injury. This may be a reflection of early excitotoxic injury (i.e., elevated Glx) and of injury associated with membrane disruption (i.e., increased Cho) secondary to diffuse axonal injury.

Research Applications of Magnetic Resonance Spectroscopy (MRS) to Investigate Psychiatric Disorders

PubMed Central

Dager, SR; Oskin, NM; Richards, TL; Posse, S

2009-01-01

Advances in magnetic resonance spectroscopy (MRS) methodology and related analytic strategies allow sophisticated testing of neurobiological models of disease pathology in psychiatric disorders. An overview of principles underlying MRS, methodological considerations and investigative approaches is presented. A review of recent research is presented that highlights innovative approaches applying MRS, in particular 1H MRS, to systematically investigate specific psychiatric disorders, including autism spectrum disorders, schizophrenia, panic disorder, major depression and bipolar disorder. PMID:19363431

MRI and MRS on preserved samples as a tool in fish ecology.

PubMed

Bock, Christian; Wermter, Felizitas C; Mintenbeck, Katja

2017-05-01

Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) gain increasing attention and importance as a tool in marine ecology. So far, studies were largely limited to morphological studies, e.g. for the creation of digital libraries. Here, the utility of MRI and MRS for ecologists is tested and exemplified using formalin preserved samples of the Antarctic silverfish, Pleuragramma antarctica. As this species lacks a swim bladder, buoyancy is attained by the deposition of large amounts of lipids that are mainly stored in subcutaneous and intermuscular lipid sacs. In this study MRI and MRS are not only used to study internal morphology, but additionally to investigate functional morphology and to measure parameters of high ecological interest. The data are compared with literature data obtained by means of traditional ecological methods. The results from this study show that MR scans are not only an alternative to histological sections (as shown before), but even allow the visualization of particular features in delicate soft tissues, such as Pleuragramma's lipid sacs. 3D rendering techniques proved to be a useful tool to study organ volumes and lipid content, which usually requires laborious chemical lipid extraction and analysis. Moreover, the application of MRS even allows for an analysis of lipids and fatty acids within lipid sacs, which wouldn't be possible using destructive methods. MRI and MRS, in particular when used in combination, have the capacity to provide useful data on parameters of high ecological relevance and thus have proven to be a highly valuable addition, if not alternative, to the classical methods. Copyright © 2016 Elsevier Inc. All rights reserved.

Insights into the factors responsible for curative effects of Aab-E-Shifa Spring Hasan Abdal (Pakistan)

NASA Astrophysics Data System (ADS)

ur Rahman, Sami; Bilal, Salma

2017-07-01

Springs are the gifts of nature on the earth as they contribute about eighty essential nutrients that are involved in more than 7000 enzymatic processes in the human body. European balneologists have recommended spring mineral waters for different therapeutic applications. In the present investigation, Aab- e- Shifa (Punjab Pakistan) spring water was analyzed due to its therapeutic behavior in the healing of various skin diseases via atomic absorption spectroscopy (AAS). It was found that besides other important minerals (Ca, Mg, K, and Na), the spring water contains the most significant antioxidant, i.e., Zn which is probably one of the major features of the curative behavior of Aab- e- Shifa. Other trace elements (Cr, Cd, Ni, Mn, Fe, and Cu) were also found to be present in the spring water under the permissible limits of various national and international organizations.

10 CFR 72.98 - Identifying regions around an ISFSI or MRS site.

Code of Federal Regulations, 2012 CFR

2012-01-01

... WASTE Siting Evaluation Factors § 72.98 Identifying regions around an ISFSI or MRS site. (a) The... ISFSI or MRS must be identified. (b) The potential regional impact due to the construction, operation or decommissioning of the ISFSI or MRS must be identified. The extent of regional impacts must be determined on the...

10 CFR 72.98 - Identifying regions around an ISFSI or MRS site.

Code of Federal Regulations, 2011 CFR

2011-01-01

... WASTE Siting Evaluation Factors § 72.98 Identifying regions around an ISFSI or MRS site. (a) The... ISFSI or MRS must be identified. (b) The potential regional impact due to the construction, operation or decommissioning of the ISFSI or MRS must be identified. The extent of regional impacts must be determined on the...

75 FR 60464 - Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-30

...)(6). Grant applications for the Advancing Patient Safety with Simulation Research Mechanism (R18... disclosure under the above-cited statutes. SEP Meeting on: Advancing Patient Safety with Simulation Research... contact Mrs. Bonnie Campbell, Committee Management Officer, Office of Extramural Research, Education and...

Proceedings from the 1982 Spring Meeting of the Nebraska Library Association, College and University Section (Seward, Nebraska, April 15-16, 1982).

ERIC Educational Resources Information Center

Franco, Elaine A., Ed.

The papers presented at the 1982 Spring Meeting of the Nebraska Library Association include: (1) "Online Catalog Cooperation among LIRS [Library Information Retrieval System] Libraries" by Roxanne Sellberg; (2) "The New 'MLA Bibliography': One Bibliographer's Perspective" by Elaine A. Franco; (3) "Serial Cancellation…

SU-E-QI-19: Evaluation of a Clinical 1.5T MRI for Prostate Cancer MRS Imaging Using a In Vivo Tumor Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, X; Chen, L; Hensley, H

2014-06-15

Purpose: Magnetic resonance spectroscopic (MRS) imaging may provide important bio-markers to distinguish normal/cancerous prostate tissue. While MRS imaging requires a high uniform magnetic field, the ability of a clinical 1.5T MRI to achieve a comparable MRS signal is of interest for radiation treatment planning/assessment. This study is to evaluate the MRS imaging of a 1.5T clinical MRI for prostate cancers by comparing with a small animal 7T MRS scanner. Methods: A tumor model was developed by implanting LNCaP tumor cells in nude mice prostates. Tumor was monitored 3 weeks after implantation using MRI, and MRS imaging was performed on themore » tumor area when the tumor reached around 1cm in diameter. The 1.5T GE clinical MR scanner and the 7T Bruker small animal MR scanner were used for each mouse. MR spectrums acquired with these scanners were analyzed and compared. The signals of Choline and Citrate were considered. Results: The prostate tumor MR spectrum under the 1.5T clinical MRI showed a similar spectrum pattern to that acquired using the 7T animal MRI. The Choline signal (3.2ppm) is clear and there is no clear peak for Citrate (2.6ppm). However, the signal magnitude for Choline is not dominant compared to the background signal under 1.5T MRI. Typical cancerous prostate tissue MR spectrum with an increased Choline signal and a reduced Citrate signal was observed. In addition, signal variation is noticeable between repeated spectrum scans. The average of these scans showed a comparable and consistent spectrum to those under 7T MRI. Conclusion: The clinical 1.5T MRI is able to acquire a MR spectrum for prostate cancer comparable to those acquired using a dedicated 7T MRS scanner. However, to achieve a consistent and reliable spectrum, multiple repeated scans were necessary to get a statistical result and reduce the noise-induced artifact. This work was supported in part by the National Cancer Institute Grant R21 CA131979 and R01CA172638.« less

A Constrained Genetic Algorithm with Adaptively Defined Fitness Function in MRS Quantification

NASA Astrophysics Data System (ADS)

Papakostas, G. A.; Karras, D. A.; Mertzios, B. G.; Graveron-Demilly, D.; van Ormondt, D.

MRS Signal quantification is a rather involved procedure and has attracted the interest of the medical engineering community, regarding the development of computationally efficient methodologies. Significant contributions based on Computational Intelligence tools, such as Neural Networks (NNs), demonstrated a good performance but not without drawbacks already discussed by the authors. On the other hand preliminary application of Genetic Algorithms (GA) has already been reported in the literature by the authors regarding the peak detection problem encountered in MRS quantification using the Voigt line shape model. This paper investigates a novel constrained genetic algorithm involving a generic and adaptively defined fitness function which extends the simple genetic algorithm methodology in case of noisy signals. The applicability of this new algorithm is scrutinized through experimentation in artificial MRS signals interleaved with noise, regarding its signal fitting capabilities. Although extensive experiments with real world MRS signals are necessary, the herein shown performance illustrates the method's potential to be established as a generic MRS metabolites quantification procedure.

Global brain metabolic quantification with whole-head proton MRS at 3 T.

PubMed

Kirov, Ivan I; Wu, William E; Soher, Brian J; Davitz, Matthew S; Huang, Jeffrey H; Babb, James S; Lazar, Mariana; Fatterpekar, Girish; Gonen, Oded

2017-10-01

Total N-acetyl-aspartate + N-acetyl-aspartate-glutamate (NAA), total creatine (Cr) and total choline (Cho) proton MRS ( 1 H-MRS) signals are often used as surrogate markers in diffuse neurological pathologies, but spatial coverage of this methodology is limited to 1%-65% of the brain. Here we wish to demonstrate that non-localized, whole-head (WH) 1 H-MRS captures just the brain's contribution to the Cho and Cr signals, ignoring all other compartments. Towards this end, 27 young healthy adults (18 men, 9 women), 29.9 ± 8.5 years old, were recruited and underwent T 1 -weighted MRI for tissue segmentation, non-localizing, approximately 3 min WH 1 H-MRS (T E /T R /T I  = 5/10/940 ms) and 30 min 1 H-MR spectroscopic imaging (MRSI) (T E /T R  = 35/2100 ms) in a 360 cm 3 volume of interest (VOI) at the brain's center. The VOI absolute NAA, Cr and Cho concentrations, 7.7 ± 0.5, 5.5 ± 0.4 and 1.3 ± 0.2 mM, were all within 10% of the WH: 8.6 ± 1.1, 6.0 ± 1.0 and 1.3 ± 0.2 mM. The mean NAA/Cr and NAA/Cho ratios in the WH were only slightly higher than the "brain-only" VOI: 1.5 versus 1.4 (7%) and 6.6 versus 5.9 (11%); Cho/Cr were not different. The brain/WH volume ratio was 0.31 ± 0.03 (brain ≈ 30% of WH volume). Air-tissue susceptibility-driven local magnetic field changes going from the brain outwards showed sharp gradients of more than 100 Hz/cm (1 ppm/cm), explaining the skull's Cr and Cho signal losses through resonance shifts, line broadening and destructive interference. The similarity of non-localized WH and localized VOI NAA, Cr and Cho concentrations and their ratios suggests that their signals originate predominantly from the brain. Therefore, the fast, comprehensive WH- 1 H-MRS method may facilitate quantification of these metabolites, which are common surrogate markers in neurological disorders. Copyright © 2017 John Wiley & Sons, Ltd.

ACHP | News | Mrs. Laura Bush Presents "Preserve America History Teacher

Science.gov Websites

. Laura Bush Presents "Preserve America History Teacher of the Year" Award to New Jersey Teacher Mrs. Laura Bush Presents "Preserve America History Teacher of the Year" Award to New Jersey Teacher October 14, 2005 Mrs. Laura Bush Presents "Preserve America History Teacher of the Year"

77 FR 58393 - Notice of Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-20

.... Healthcare Safety and Quality Improvement Research Date: October 31, 2012 (Open from 8:30 a.m. to 8:45 a.m... meetings.) Mrs. Bonnie Campbell, Committee Management Officer, Office of Extramural Research Education and Priority Populations, AHRQ 540, Gaither Road, Suite 2000, Rockville, Maryland 20850, Telephone (301) 427...

Serial 1H-MRS in GM2 gangliosidoses.

PubMed

Assadi, Mitra; Baseman, Susan; Janson, Christopher; Wang, Dah-Jyuu; Bilaniuk, Larissa; Leone, Paola

2008-03-01

GM2 gangliosidoses are a group of neuronal storage disorders caused by deficiency in the lysosomal enzyme hexosaminidase A. Clinically, the disease is marked by a relentless encephalopathy. Proton magnetic resonance spectroscopy (1H-MRS) provides in-vivo measurement of various brain metabolites including N-acetyl aspartate+N-acetyl aspartate glutamate (NAA), myo-inositol (mI), choline (Cho) and creatine (Cr). The NAA represents neuronal integrity while elevation in the mI reflects abnormal inflammation and gliosis in the brain tissue. An elevation in the Cho levels suggest cell membrane breakdown and demyelination. We report the clinical and laboratory data in two patients with GM2 gangliosidoses. Serial 1H-MRS evaluations were performed to drive metabolite ratios of NAA/Cr, mI/Cr and Cho/Cr. We acquired the data from four regions of interest (ROI) according to a standard protocol. The results documented a progressive elevation in mI/Cr in all four ROI in patient one and only one ROI (occipital gray matter) in patient 2. We also documented a decline in the NAA/Cr ratios in both cases in most ROI. These results were compared to six age-matched controls and confirmed statistically significant elevation in the mI in our cases. In conclusion, 1H-MRS alterations were suggestive of neuronal loss and inflammation in these patients. 1H-MRS may be a valuable tool in monitoring the disease progress and response to therapy in GM2 gangliosidoses. Elevation in the mI may prove to be more sensitive than the other metabolite alterations.

Impact of molecule-based magnetic materials: A critical outlook

NASA Astrophysics Data System (ADS)

Rentschler, Eva; Affronte, Marco; Massobrio, Carlo; Rabu, Pierre; Veciana, Jaume

2009-05-01

A critical outlook of the field of molecular magnetic materials is presented. This article is inspired by an international symposium devoted to the " Design, Characterization and Modelling of Molecule-Based Magnetic Materials (DCM4-II)" that took place at Strasbourg (France), from May 28th to June 1st, within the E-MRS 2007 Spring Meeting (Symposium R) organized by the European Materials Research Society in collaboration with the European Science Foundation. A series of papers linked to this symposium are published in this issue and in the previous issue (Volume 11, Issue 4) of Solid State Sciences.

78 FR 58525 - Meeting of the National Commission on the Structure of the Air Force

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-24

... DEPARTMENT OF DEFENSE Office of the Secretary Meeting of the National Commission on the Structure... following Federal Advisory Committee closed meeting of the National Commission on the Structure of the Air... INFORMATION CONTACT: Mrs. Marcia Moore, Designated Federal Officer, National Commission on the Structure of...

76 FR 41195 - National Forests In Mississippi, Tombigbee and Holly Springs Resource Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

... DEPARTMENT OF AGRICULTURE Forest Service National Forests In Mississippi, Tombigbee and Holly Springs Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Tombigbee and Holly Springs National Forests Resource Advisory Committee will meet in Starkville, MS. The...

76 FR 41196 - National Forests in Mississippi, Tombigbee and Holly Springs Resource Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

... DEPARTMENT OF AGRICULTURE Forest Service National Forests in Mississippi, Tombigbee and Holly Springs Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Tombigbee and Holly Springs National Forests Resource Advisory Committee will meet in Starkville, MS. The...

Magnetic resonance spectroscopy (MRS) of vertebral column – an additional tool for evaluation of aggressiveness of vertebral haemangioma like lesion

PubMed Central

Jeromel, Miran; Podobnik, Janez

2014-01-01

Background Most vertebral haemangioma are asymptomatic and discovered incidentally. Sometimes the symptomatic lesions present with radiological signs of aggressiveness and their appearance resemble other aggressive lesions (e.g. solitary plasmacytoma). Case report. We present a patient with large symptomatic aggressive haemangioma like lesion in 12th thoracic vertebra in which a magnetic resonance spectroscopy (MRS) was used to analyse fat content within the lesion. The lesion in affected vertebrae showed low fat content with 33% of fat fraction (%FF). The fat content in non-affected (1st lumbar) vertebra was as expected for patient’s age (68%). Based on MRS data, the lesion was characterized as an aggressive haemangioma. The diagnosis was confirmed with biopsy, performed during the treatment – percutaneous vertebroplasty. Conclusions The presented case shows that MRS can be used as an additional tool for evaluation of aggressiveness of vertebral haemangioma like lesions. PMID:24991203

Acquisition of a SAXS Facility for the Study of Novel Polymer Nanocomposite Membranes

DTIC Science & Technology

2015-02-19

at the 2015 MRS Spring National Meeting, San Francisco , CA, April, 2015. 2. A. Millet and D. Suleiman “Sulfonation and Characterization of Poly...the 2015 ACS PRISM Meeting San Juan , PR March, 2015. 3. D. Suleiman “Polymer Nanocomposites: Technology for the XXI Century.” Oral Key Note...have been using the equipment: 1. Rinaldo Díaz 2. Arnaldo López 3. Alexander Millet 4. Nataira Pagán 5. Luis Sotomayor 6. Vanessa Torres 7

10 CFR 72.98 - Identifying regions around an ISFSI or MRS site.

Code of Federal Regulations, 2014 CFR

2014-01-01

... regional extent of external phenomena, man-made or natural, that are used as a basis for the design of the ISFSI or MRS must be identified. (b) The potential regional impact due to the construction, operation or decommissioning of the ISFSI or MRS must be identified. The extent of regional impacts must be determined on the...

10 CFR 72.98 - Identifying regions around an ISFSI or MRS site.

Code of Federal Regulations, 2013 CFR

2013-01-01

... regional extent of external phenomena, man-made or natural, that are used as a basis for the design of the ISFSI or MRS must be identified. (b) The potential regional impact due to the construction, operation or decommissioning of the ISFSI or MRS must be identified. The extent of regional impacts must be determined on the...

10 CFR 72.98 - Identifying regions around an ISFSI or MRS site.

Code of Federal Regulations, 2010 CFR

2010-01-01

... regional extent of external phenomena, man-made or natural, that are used as a basis for the design of the ISFSI or MRS must be identified. (b) The potential regional impact due to the construction, operation or decommissioning of the ISFSI or MRS must be identified. The extent of regional impacts must be determined on the...

Microscopic Optical Characterization of ZnO Bulk Crystals, Free Standing III-Nitride Substrates and III-V Structures for Non-Linear Optics

DTIC Science & Technology

2008-10-01

concentration (M.R. Phillips, M.Wagner, O.Gelhausen, V.Coleman, J.B. Brady, C. Jagadish, E. Malguth, A. Hoffmann, E.M. Goldys , J.J. Rusell; E.MRS...Malguth, A. Hoffmann, E.M. Goldys , J.J. Rusell; E.MRS Fall meeting, Symp. F, (Warsaw, Poland, 2004)); it suggests that the shift towards the red of

Brain glutamate in medication-free depressed patients: a proton MRS study at 7 Tesla.

PubMed

Godlewska, Beata R; Masaki, Charles; Sharpley, Ann L; Cowen, Philip J; Emir, Uzay E

2017-12-11

The possible role of glutamate in the pathophysiology and treatment of depression is of intense current interest. Proton magnetic resonance spectroscopy (MRS) enables the detection of glutamate in the living human brain and meta-analyses of previous MRS studies in depressed patients have suggested that glutamate levels are decreased in anterior brain regions. Nevertheless, at conventional magnetic field strengths [1.5-3 Tesla (T)], it is difficult to separate glutamate from its metabolite and precursor, glutamine, with the two often being measured together as Glx. In contrast, MRS at 7 T allows clear spectral resolution of glutamate and glutamine. We studied 55 un-medicated depressed patients and 50 healthy controls who underwent MRS scanning at 7 T with voxels placed in anterior cingulate cortex, occipital cortex and putamen (PUT). Neurometabolites were calculated using the unsuppressed water signal as a reference. Compared with controls, depressed patients showed no significant difference in glutamate in any of the three voxels studied; however, glutamine concentrations in the patients were elevated by about 12% in the PUT (p < 0.001). The increase in glutamine in PUT is of interest in view of the postulated role of the basal ganglia in the neuropsychology of depression and is consistent with elevated activity in the descending cortical glutamatergic innervation to the PUT. The basal ganglia have rarely been the subject of MRS investigations in depressed patients and further MRS studies of these structures in depression are warranted.

A novel approach for baseline correction in 1H-MRS signals based on ensemble empirical mode decomposition.

PubMed

Parto Dezfouli, Mohammad Ali; Dezfouli, Mohsen Parto; Rad, Hamidreza Saligheh

2014-01-01

Proton magnetic resonance spectroscopy ((1)H-MRS) is a non-invasive diagnostic tool for measuring biochemical changes in the human body. Acquired (1)H-MRS signals may be corrupted due to a wideband baseline signal generated by macromolecules. Recently, several methods have been developed for the correction of such baseline signals, however most of them are not able to estimate baseline in complex overlapped signal. In this study, a novel automatic baseline correction method is proposed for (1)H-MRS spectra based on ensemble empirical mode decomposition (EEMD). This investigation was applied on both the simulated data and the in-vivo (1)H-MRS of human brain signals. Results justify the efficiency of the proposed method to remove the baseline from (1)H-MRS signals.

75 FR 6393 - Farm Credit Administration Board; Sunshine Act; Regular Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-09

... requiring assistance should make arrangements in advance. The matters to be considered at the meeting are... Unified Agenda of Federal Regulatory and Deregulatory Actions and Spring 2010 Regulatory Performance Plan C. Reports Office of Management Services Quarterly Report Dated: February 4, 2010. Roland E. Smith...

Design, Fabrication, and Analysis of a Hybrid FIBER Composite Monoleaf Spring Using Carbon and E-Glass Fibers for Automotive Suspension Applications

NASA Astrophysics Data System (ADS)

Sureshkumar, M.; Tamilselvam, P.; Kumaravelan, R.; Dharmalingam, R.

2014-03-01

The leaf spring is an important component that provides suspension and plays a vital role in automotive applications. As a vehicle travels, a tremendous force, mostly in terms of a fatigue load, is applied to the leaf spring assembly, particularly to the eye point of the rear axle. In a vehicle with rear-wheel drive, the leaf spring is subject to twisting forces that are opposite in direction and magnitude during the acceleration of drive wheels. A multileaf spring provides an additional strength, but lacks the flexibility and increases the overall weight of the vehicle. Considering the loading conditions, the availability of space in a vehicle, and geometrical considerations, a composite monoleaf spring is designed. In due consideration of the tensile behavior, fatigue resistance, chipping resistance, and base part resistance, a hybrid laminated spring is constructed for the purpose. The present study focuses on an analysis and behavior of a monoleaf spring made of hybrid composite materials, i.e., carbon and E-glass fibers. It is observed that the natural frequency of a hybrid composite leaf spring is twice the frequency of a conventional leaf spring, particularly in the vertical direction, which means that the occurrences of resonance will be less. Also, it is observed that the stress produced in it is lower than that in a conventional leaf spring. The hybrid composite monoleaf spring proved to have better impact and tensile behavior than a steel one.

News Conference: Take a hold of Hands-on Science Meeting: Prize-winning physics-education talks are a highlight of the DPG spring meeting in Jena Event: Abstracts flow in for ICPE-EPEC 2013 Schools: A new Schools Physics Partnership in Oxfordshire Conference: 18th MPTL is forum for multimedia in education Meeting: Pursuing playful science with Science on Stage Forthcoming events

NASA Astrophysics Data System (ADS)

2013-03-01

Conference: Take a hold of Hands-on Science Meeting: Prize-winning physics-education talks are a highlight of the DPG spring meeting in Jena Event: Abstracts flow in for ICPE-EPEC 2013 Schools: A new Schools Physics Partnership in Oxfordshire Conference: 18th MPTL is forum for multimedia in education Meeting: Pursuing playful science with Science on Stage Forthcoming events

First international E. coli genome meeting

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-12-31

This volume is a collection of abstracts of oral presentations and poster sessions of studies reported at the First International E. Coli Genome Meeting, held September 10-14, 1992 at the University of Wisconsin.

First international E. coli genome meeting

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-01-01

This volume is a collection of abstracts of oral presentations and poster sessions of studies reported at the First International E. Coli Genome Meeting, held September 10-14, 1992 at the University of Wisconsin.

ACHP | News | ACHP Spring Business Meeting

Science.gov Websites

Meeting Chairman John L. Nau, III awarded the Federal Communications Commission and the National Endowment Chairman John L. Nau, III NEH Acting Chairwoman Carole Watson receives the award from ACHP Chairman John L

News Festival: Science on stage deadline approaches Conference: Welsh conference attracts teachers Data: New phase of CERN openlab tackles exascale IT challenges for science Meeting: German Physical Society holds its physics education spring meeting Conference: Association offers golden opportunity in Norway Competition: So what's the right answer then?

NASA Astrophysics Data System (ADS)

2012-07-01

Festival: Science on stage deadline approaches Conference: Welsh conference attracts teachers Data: New phase of CERN openlab tackles exascale IT challenges for science Meeting: German Physical Society holds its physics education spring meeting Conference: Association offers golden opportunity in Norway Competition: So what's the right answer then?

Leopold Fellows meet

NASA Astrophysics Data System (ADS)

Hartmann, Dennis L.

Communicating the results of environmental science research to nonscientists was the focus of a week-long meeting of fellows of the Aldo Leopold Leadership Program (ALLP) in June. Participating were 20 mid-career university facultymembers, the first group of ALLP fellows to be selected.Discussions were held on the role of scientists in society, techniques for effective leadership, improving communications skills, and working productively with news media. The training program considers both print and broadcast media as well as other outreach vehicles. The meeting was held at Kah Nee Ta Resort on the Warm Springs Indian Reservation, Warm Springs, Oregon, June 15-21, 1999.

Reduced Warburg Effect in Cancer Cells Undergoing Autophagy: Steady- State 1H-MRS and Real-Time Hyperpolarized 13C-MRS Studies

PubMed Central

Wong Te Fong, Anne-Christine; Hill, Deborah K.; Orton, Matthew R.; Parkes, Harry G.; Koh, Dow-Mu; Robinson, Simon P.; Leach, Martin O.; Eykyn, Thomas R.; Chung, Yuen-Li

2014-01-01

Autophagy is a highly regulated, energy dependent cellular process where proteins, organelles and cytoplasm are sequestered in autophagosomes and digested to sustain cellular homeostasis. We hypothesized that during autophagy induced in cancer cells by i) starvation through serum and amino acid deprivation or ii) treatment with PI-103, a class I PI3K/mTOR inhibitor, glycolytic metabolism would be affected, reducing flux to lactate, and that this effect may be reversible. We probed metabolism during autophagy in colorectal HT29 and HCT116 Bax knock-out cells using hyperpolarized 13C-magnetic resonance spectroscopy (MRS) and steady-state 1H-MRS. 24 hr PI103-treatment or starvation caused significant reduction in the apparent forward rate constant (kPL) for pyruvate to lactate exchange compared with controls in HT29 (100 μM PI-103: 82%, p = 0.05) and HCT116 Bax-ko cells (10 μM PI-103: 53%, p = 0.05; 20 μM PI-103: 42%, p<0.0001; starvation: 52%, p<0.001), associated with reduced lactate excretion and intracellular lactate in all cases, and unchanged lactate dehydrogenase (LDH) activity and increased NAD+/NADH ratio following PI103 treatment or decreased LDH activity and unchanged NAD+/NADH ratio following starvation. After 48 hr recovery from PI103 treatment, kPL remained below control levels in HT29 cells (74%, p = 0.02), and increased above treated values, but remained below 24 hr vehicle-treated control levels in HCT116 Bax-ko cells (65%, p = 0.004) both were accompanied by sustained reduction in lactate excretion, recovery of NAD+/NADH ratio and intracellular lactate. Following recovery from starvation, kPL was significantly higher than 24 hr vehicle-treated controls (140%, p = 0.05), associated with increased LDH activity and total cellular NAD(H). Changes in kPL and cellular and excreted lactate provided measureable indicators of the major metabolic processes accompanying starvation- and drug-induced autophagy. The changes are reversible

Mapping MRI/MRS Parameters with Genetic Over-expression Profiles In Human Prostate Cancer: Demonstrating the Potential

PubMed Central

Lenkinski, Robert E.; Bloch, B. Nicholas; Liu, Fangbing; Frangioni, John V.; Perner, Sven; Rubin, Mark A.; Genega, Elizabeth; Rofsky, Neil M.; Gaston, Sandra M.

2009-01-01

Magnetic resonance imaging (MRI) and MR spectroscopy can probe a variety of physiological (e.g. blood vessel permeability) and metabolic characteristics of prostate cancer. However, little is known about the changes in gene expression that underlie the spectral and imaging features observed in prostate cancer. Tumor induced changes in vascular permeability and angiogenesis are thought to contribute to patterns of dynamic contrast enhanced (DCE) MRI images of prostate cancer even though the genetic basis of tumor vasculogenesis is complex and the specific mechanisms underlying these DCEMRI features have not yet been determined. In order to identify the changes in gene expression that correspond to MRS and DCEMRI patterns in human prostate cancers, we have utilized tissue print micropeel techniques to generate “whole mount” molecular maps of radical prostatectomy specimens that correspond to pre-surgical MRI/MRS studies. These molecular maps include RNA expression profiles from both Affymetrix GeneChip microarrays and quantitative reverse transcriptase PCR (qrt-PCR) analysis, as well as immunohistochemical studies. Using these methods on patients with prostate cancer, we found robust over-expression of choline kinase a in the majority of primary tumors. We also observed overexpression of neuropeptide Y (NPY), a newly identified angiogenic factor, in a subset of DCEMRI positive prostate cancers. These studies set the stage for establishing MRI/MRS parameters as validated biomarkers for human prostate cancer. PMID:18752015

75 FR 22163 - Meeting of the Federal Advisory Committee on Juvenile Justice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-27

... Federal Advisory Committee on Juvenile Justice AGENCY: Office of Juvenile Justice and Delinquency... Justice and Delinquency Prevention (OJJDP) announces the Spring meeting of the Federal Advisory Committee...)(2)(C-E) of the Juvenile Justice and Delinquency Prevention Act of 2002. The FACJJ is composed of one...

Academic Libraries: Reaching Up and Stretching Out. Proceedings of the Spring Meeting of the Nebraska Library Association, College and University Section (Crete, Nebraska, May 25, 1990).

ERIC Educational Resources Information Center

Giesecke, Joan, Ed.

This proceedings report provides the papers presented at the 1990 spring meeting. Titles and authors of the seven papers are as follows: (1) "Marketing without a Plan: Seizing Outreach Opportunities as They Occur" (Joan Giesecke, Gail Egbers, Kay Logan-Peters, and Debra Pearson); (2) "Historians and the Academic Library: Traditional…

Method for Controlled Mitochondrial Perturbation during Phosphorus MRS in Children

PubMed Central

Cree-Green, Melanie; Newcomer, Bradley R.; Brown, Mark; Hull, Amber; West, Amy D.; Singel, Debra; Reusch, Jane E.B.; McFann, Kim; Regensteiner, Judith G.; Nadeau, Kristen J.

2014-01-01

Introduction Insulin resistance (IR) is increasingly prevalent in children, and may be related to muscle mitochondrial dysfunction, necessitating development of mitochondrial assessment techniques. Recent studies used 31Phosphorus magnetic resonance spectroscopy (31P-MRS), a non-invasive technique appealing for clinical research. 31P-MRS requires exercise at a precise percentage of maximum volitional contraction (MVC). MVC measurement in children, particularly with disease, is problematic due to variability in perception of effort and motivation. We therefore developed a method to predict MVC, using maximal calf muscle cross-sectional area (MCSA) to assure controlled and reproducible muscle metabolic perturbations. Methods Data were collected from 66 sedentary 12–20 year-olds. Plantar flexion-volitional MVC was assessed using a MRI-compatible exercise treadle device. MCSA of the calf muscles were measured from MRI images. Data from the first 26 participants were utilized to model the relationship between MVC and MCSA (predicted MVC = 24.763+0.0047*MCSA). This model was then applied to the subsequent 40 participants. Results Volitional vs. model-predicted mean MVC was 43.9±0.8 kg vs. 44.2±1.81 (P=0.90). 31P-MRS results when predicted and volitional MVC were similar showed expected changes during volitional MVC-based exercise. In contrast, volitional MVC was markedly lower than predicted in 4 participants, and produced minimal metabolic perturbation. Upon repeat testing, these individuals could perform their predicted MVC with coaching, which produced expected metabolic perturbations. Conclusions Compared to using MVC testing alone, utilizing MRI to predict muscle strength allows for a more accurate and standardized 31P-MRS protocol during exercise in children. This method overcomes a major obstacle in assessing mitochondrial function in youth. These studies have importance as we seek to determine the role of mitochondrial function in youth with IR and diabetes

Challenges in the Assessment and Treatment of Health Anxiety: The Case of Mrs. A.

ERIC Educational Resources Information Center

McCabe, Randi E.; Antony, Martin M.

2004-01-01

Health anxiety can present a challenge for clinicians, both from the perspective of assigning a "DSM-IV" diagnosis and in developing an appropriate treatment plan. The case of Mrs. A. illustrates some of the complexities that arise in the diagnosis and treatment of health anxiety. Mrs. A. is a 60-year-old retired teacher who presented to a…

Quality management in in vivo proton MRS.

PubMed

Pedrosa de Barros, Nuno; Slotboom, Johannes

2017-07-15

The quality of MR-Spectroscopy data can easily be affected in in vivo applications. Several factors may produce signal artefacts, and often these are not easily detected, not even by experienced spectroscopists. Reliable and reproducible in vivo MRS-data requires the definition of quality requirements and goals, implementation of measures to guarantee quality standards, regular control of data quality, and a continuous search for quality improvement. The first part of this review includes a general introduction to different aspects of quality management in MRS. It is followed by the description of a series of tests and phantoms that can be used to assure the quality of the MR system. In the third part, several methods and strategies used for quality control of the spectroscopy data are presented. This review concludes with a reference to a few interesting techniques and aspects that may help to further improve the quality of in vivo MR-spectra. Copyright © 2017 Elsevier Inc. All rights reserved.

Resting state glutamate predicts elevated pre-stimulus alpha during self-relatedness: A combined EEG-MRS study on "rest-self overlap".

PubMed

Bai, Yu; Nakao, Takashi; Xu, Jiameng; Qin, Pengmin; Chaves, Pedro; Heinzel, Alexander; Duncan, Niall; Lane, Timothy; Yen, Nai-Shing; Tsai, Shang-Yueh; Northoff, Georg

2016-01-01

Recent studies have demonstrated neural overlap between resting state activity and self-referential processing. This "rest-self" overlap occurs especially in anterior cortical midline structures like the perigenual anterior cingulate cortex (PACC). However, the exact neurotemporal and biochemical mechanisms remain to be identified. Therefore, we conducted a combined electroencephalography (EEG)-magnetic resonance spectroscopy (MRS) study. EEG focused on pre-stimulus (e.g., prior to stimulus presentation or perception) power changes to assess the degree to which those changes can predict subjects' perception (and judgment) of subsequent stimuli as high or low self-related. MRS measured resting state concentration of glutamate, focusing on PACC. High pre-stimulus (e.g., prior to stimulus presentation or perception) alpha power significantly correlated with both perception of stimuli judged to be highly self-related and with resting state glutamate concentrations in the PACC. In sum, our results show (i) pre-stimulus (e.g., prior to stimulus presentation or perception) alpha power and resting state glutamate concentration to mediate rest-self overlap that (ii) dispose or incline subjects to assign high degrees of self-relatedness to perceptual stimuli.

In vivo MRS and MRSI: Performance analysis, measurement considerations and evaluation of metabolite concentration images

NASA Astrophysics Data System (ADS)

Vikhoff-Baaz, Barbro

2000-10-01

The doctoral thesis concerns development, evaluation and performance of quality assessment methods for volume- selection methods in 31P and 1H MR spectroscopy (MRS). It also contains different aspects of the measurement procedure for 1H MR spectroscopic imaging (MRSI) with application on the human brain, image reconstruction of the MRSI images and evaluation methods for lateralization of temporal lobe epilepsy (TLE). Two complementary two-compartment phantoms and evaluation methods for quality assessment of 31P MRS in small-bore MR systems were presented. The first phantom consisted of an inner cube inside a sphere phantom where measurements with and without volume selection where compared for various VOI sizes. The multi-centre showed that the evaluated parameters provide useful information of the performance of volume-selective MRS at the MR system. The second phantom consisted of two compartments divided by a very thin wall and was found useful for measurements of the appearance and position of the VOI profile in specific gradient directions. The second part concerned 1H MRS and MRSI of whole-body MR systems. Different factors that may degrade or complicate the measurement procedure like for MRSI were evaluated, e.g. the volume selection performance, contamination, susceptibility and motion. Two interpolation methods for reconstruction of MRSI images were compared. Measurements and computer simulations showed that Fourier interpolation correctly visualizes the information inherent in the data set, while the results were dependent on the position of the object relative the original matrix using Cubic spline interpolation. Application of spatial filtering may improve the image representation of the data. Finally, 1H MRSI was performed on healthy volunteers and patients with temporal lobe epilepsy (TLE). Metabolite concentration images were used for lateralization of TLE, where the signal intensity in the two hemispheres were compared. Visual analysis of the

A Breath of Spring Air

ERIC Educational Resources Information Center

Grady, Marilyn L.

2009-01-01

The most promising sights of spring in Nebraska this year were two conferences for women. One event, sponsored by Metropolitan Community College in Omaha, was a Women's History Month Tea. A second conference was the meeting of the Nebraska Women in Higher Education. These two events suggest that there is a continuing interest in women's leadership…

Upgrading a Social Media Strategy to Increase Twitter Engagement During the Spring Annual Meeting of the American Society of Regional Anesthesia and Pain Medicine.

PubMed

Schwenk, Eric S; Jaremko, Kellie M; Gupta, Rajnish K; Udani, Ankeet D; McCartney, Colin J L; Snively, Anne; Mariano, Edward R

Microblogs known as "tweets" are a rapid, effective method of information dissemination in health care. Although several medical specialties have described their Twitter conference experiences, Twitter-related data in the fields of anesthesiology and pain medicine are sparse. We therefore analyzed the Twitter content of 2 consecutive spring meetings of the American Society of Regional Anesthesia and Pain Medicine using publicly available online transcripts. We also examined the potential contribution of a targeted social media campaign on Twitter engagement during the conferences. The original Twitter meeting content was largely scientific in nature and created by meeting attendees, the majority of whom were nontrainee physicians. Physician trainees, however, represent an important and increasing minority of Twitter contributors. Physicians not in attendance predominantly contributed via retweeting original content, particularly picture-containing tweets, and thus increased reach to nonattendees. A social media campaign prior to meetings may help increase the reach of conference-related Twitter discussion.

MRS study of meningeal hemangiopericytoma and edema: a comparison with meningothelial meningioma.

PubMed

Righi, Valeria; Tugnoli, Vitaliano; Mucci, Adele; Bacci, Antonella; Bonora, Sergio; Schenetti, Luisa

2012-10-01

Intracranial hemangiopericytomas (HPCs) are rare tumors and their radiological appearance resembles that of meningiomas, especially meningothelial meningiomas. To increase the knowledge on the biochemical composition of this type of tumor for better diagnosis and prognosis, we performed a molecular study using ex vivo high resolution magic angle spinning (HR-MAS) magnetic resonance spectroscopy (MRS) perfomed on HPC and peritumoral edematous tissues. Moreover, to help in the discrimination between HPC and meningothelial meningioma we compared the ex vivo HR-MAS spectra of samples from one patient with HPC and 5 patients affected by meningothelial meningioma. Magnetic resonance imaging (MRI), in vivo localized single voxel 1H-MRS was also performed on the same patients prior to surgery and the in vivo and ex vivo MRS spectra were compared. We observed the presence of OH-butyrate, together with glucose in HPC and a low amount of N-acetylaspartate in the edema, that may reflect neuronal alteration responsible for associated epilepsy. Many differences between HPC and meningothelial meningioma were identified. The relative ratios of myo-inositol, glucose and gluthatione with respect to glutamate are higher in HPC compared to meningioma; whereas the relative ratios of creatine, glutamine, alanine, glycine and choline-containing compounds with respect to glutamate are lower in HPC compared to meningioma. These data will be useful to improve the interpretation of in vivo MRS spectra resulting in a more accurate diagnosis of these rare tumors.

Bone marrow fat quantification in the presence of trabecular bone: initial comparison between water-fat imaging and single-voxel MRS

PubMed Central

Karampinos, Dimitrios C.; Melkus, Gerd; Baum, Thomas; Bauer, Jan S.; Rummeny, Ernst J.; Krug, Roland

2013-01-01

Purpose The purpose of the present study was to test the relative performance of chemical shift-based water-fat imaging in measuring bone marrow fat fraction in the presence of trabecular bone, having as reference standard the single-voxel magnetic resonance spectroscopy (MRS). Methods Six-echo gradient echo imaging and single-voxel MRS measurements were performed on the proximal femur of seven healthy volunteers. The bone marrow fat spectrum was characterized based on the magnitude of measurable fat peaks and an a priori knowledge of the chemical structure of triglycerides, in order to accurately extract the water peak from the overlapping broad fat peaks in MRS. The imaging-based fat fraction results were then compared to the MRS-based results both without and with taking into consideration the presence of short T2* water components in MRS. Results There was a significant underestimation of the fat fraction using the MRS model not accounting for short T2* species with respect to the imaging-based water fraction. A good equivalency was observed between the fat fraction using the MRS model accounting for short T2* species and the imaging-based fat fraction (R2=0.87). Conclusion The consideration of the short T2* water species effect on bone marrow fat quantification is essential when comparing MRS-based and imaging-based fat fraction results. PMID:23657998

2. WEST FRONT ENTRANCE, WITH OWNERS MR. & MRS. ISACC ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. WEST FRONT ENTRANCE, WITH OWNERS MR. & MRS. ISACC N. HAGAN (WHO CONTRACTED WITH FRANK LLOYD WRIGHT FOR THE DESIGN OF THIS HOUSE) - Isaac N. Hagan House, Kentuck Knob, U.S. Route 40 vicinity (Stewart Township), Chalkhill, Fayette County, PA

View looking south of first floor bedroom of Mrs. Perry ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View looking south of first floor bedroom of Mrs. Perry (Jessie) Belmont/Right Worthy Grand Secretary's Living Room - Perry Belmont House, 1618 New Hampshire Avenue, NW, Washington, District of Columbia, DC

1. Historic American Buildings Survey Photographer Unknown. Furnished by Mrs ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey Photographer Unknown. Furnished by Mrs Mecia, Tombstone, Arizona. Date Unknown GENERAL VIEW MAIN CHURCH (SOUTHEAST ELEVATION). - San Xavier del Bac Mission, Mission Road, Tucson, Pima County, AZ

A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions.

PubMed

Mühlenhoff, Ulrich; Stadler, Jochen A; Richhardt, Nadine; Seubert, Andreas; Eickhorst, Thomas; Schweyen, Rudolf J; Lill, Roland; Wiesenberger, Gerlinde

2003-10-17

The yeast genes MRS3 and MRS4 encode two members of the mitochondrial carrier family with high sequence similarity. To elucidate their function we utilized genome-wide expression profiling and found that both deletion and overexpression of MRS3/4 lead to up-regulation of several genes of the "iron regulon." We therefore analyzed the two major iron-utilizing processes, heme formation and Fe/S protein biosynthesis in vivo, in organello (intact mitochondria), and in vitro (mitochondrial extracts). Radiolabeling of yeast cells with 55Fe revealed a clear correlation between MRS3/4 expression levels and the efficiency of these biosynthetic reactions indicating a role of the carriers in utilization and/or transport of iron in vivo. Similar effects on both heme formation and Fe/S protein biosynthesis were seen in organello using mitochondria isolated from cells grown under iron-limiting conditions. The correlation between MRS3/4 expression levels and the efficiency of the two iron-utilizing processes was lost upon detergent lysis of mitochondria. As no significant changes in the mitochondrial membrane potential were observed upon overexpression or deletion of MRS3/4, our results suggest that Mrs3/4p carriers are directly involved in mitochondrial iron uptake. Mrs3/4p function in mitochondrial iron transport becomes evident under iron-limiting conditions only, indicating that the two carriers do not represent the sole system for mitochondrial iron acquisition.

Photocopy of a postcard, circa 1910 from Mr. and Mrs. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of a postcard, circa 1910 from Mr. and Mrs. Buford Buoy, Chinton, Missouri) SOUTH AND EAST FACADES BEFORE ALTERATION OF DOORS - Bethlehem Baptist Church, Route AA & 35 vicinity, Clinton, Henry County, MO

Mrs Hitler and her doctor.

PubMed

Macleod, Sandy

2005-12-01

The doctor who attended the mother of Adolf Hitler in her terminal illness has been blamed as a cause of the Holocaust. The medical details recorded of this professional relationship are presented and discussed. Dr Bloch's medical care of Mrs Hitler was consistent with the prevailing medical practice of the management of fungating breast carcinoma. Indeed, the general practitioner's care and attention of the family appear to have been astute and supportive. There is nothing to suggest that Dr Bloch's medical care was other than competent. Doctors who have the (mis)fortune to professionally attend major figures of history may be unfairly viewed, despite their appropriate and adequate care.

Spring Break versus Spring Broken: Predictive Utility of Spring Break Alcohol Intentions and Willingness at Varying Levels of Extremity

PubMed Central

Litt, Dana M.; Lewis, Melissa A.; Patrick, Megan E.; Rodriguez, Lindsey; Neighbors, Clayton; Kaysen, Debra L.

2013-01-01

Objective Within the domain of risk-related behavior, many times the decision to engage is not a product of premeditation or intention. The Prototype Willingness model was created to capture and explain the unintended element of risk behavior. The present study aimed to evaluate the importance of willingness versus intention, two important constructs within the Prototype Willingness model, in relation to Spring Break drinking behavior when assessed at both high and low extremities. Method College undergraduates (N = 275) completed questionnaires prior to Spring Break regarding their anticipated Spring Break activities. Willingness and intention were assessed for different levels of risk. Specifically, participants indicated the extent to which they intended to (a) get drunk and (b) drink enough to black out or pass out; and the extent to which they were willing to (a) get drunk and (b) drink enough to black out or pass out. When classes resumed following Spring Break, the students indicated the extent to which they actually (a) got drunk and (b) drank enough to black out or pass out. Results Results demonstrated that when the health-related risk was lower (i.e., getting drunk), intention was a stronger predictor of behavior than was willingness. However, as the level of risk increased (i.e., getting drunk enough to black out or pass out), willingness more strongly predicted behavior. Conclusion The present study suggests that willingness and intentions differentially predict Spring Break alcohol-related behavior depending on the extremity of behavior in question. Implications regarding alcohol interventions are discussed. PMID:23404667

Moving AGU Meetings sites [Comment to “Fall Meeting site”

NASA Astrophysics Data System (ADS)

Lanzerotti, L. J.; Maclennan, C. C.

1984-04-01

A recent letter to Eos by AGU member Dan Baker (March 13, 1984, p. 98) suggested that a method of reducing the attendance at the Fall AGU meeting would be to move it from San Francisco to his namesake, namely Bakersfield. He cited as a precedent the probably reduced attendance at the (at that time) upcoming Spring Meeting to be held in Cincinnati. While neither of us is promoting cities with names similar to ours, nevertheless we both believe that the recent meeting held in Cincinnati was a great success, even with the reduced number of registrants. The arrangements in the Convention Center, as well as the proximity of the hotels to the convention center and the amenities in the hotels were all excellent, and easily matched or surpassed the facilities in any of the cities in which the major meetings have been held to this time. Furthermore, we would like to make a qualitative judgment that the number of attendees at the individual sessions were perhaps as large as in a Baltimore or Washington meeting. In those meetings the number of registrants may have been larger, but the number of attendees at the given session may have been smaller; a significant proportion of the attendees at any given time would likely be visiting the offices of their contract monitors. Admittedly, the Spring Meeting has been an ideal opportunity to both attend scientific sessions and to lobby for additional research support. However, such lobbying does not necessarily make for increased attendance at the scientific sessions.

Photocopy of photograph (from Mrs. Martin, grandniece of John French, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of photograph (from Mrs. Martin, grandniece of John French, Clinton, Missouri) Circa 1900, photographer unknown JOHN AND ALMIRA FRENCH IN FRONT OF WEST AND SOUTH FACADES - John French Farm, South Grand River, Deepwater, Henry County, MO

Orthogonal array deciphering MRS medium requirements for isolated Lactobacillus rhamnosus ZY with cell properties characterization.

PubMed

Zhang, Yu; Ng, I-Son; Yao, Chuanyi; Lu, Yinghua

2014-09-01

Lactobacillus rhamnosus is a well-known lactic acid bacterium (LAB), but a new ZY strain was isolated for the first time from commercial probiotic powder recently. Although many studies have focused on developing cost-effective media for the production of LAB, the de Man, Rogosa and Sharpe (MRS) medium is still the most common medium for bioprocesses. The aim of the current study is to decipher the composition of MRS based on a statistical approach, which will allow a higher biomass of Lactobacillus to be obtained. In Taguchi's approach, an L27 orthogonal array was adopted to evaluate the significance of 10 ingredients in MRS, in which the effects of the components were ranked according to their effect on biomass at OD600 as dextrose > MnSO4·H2O > beef extract > CH3COONa > MgSO4 > yeast extract > proteose peptone > K2HPO4 > ammonium citrate > Tween 80. Although the individual trace elements of ammonium citrate, K2HPO4, CH3COONa and MgSO4 in MRS had an insignificant influence on the biomass after statistical analysis, the total elimination of trace elements would predominantly affect the cell growth of Lactobacillus. Further characterization of the cell properties through attenuated total reflectance of Fourier transform infrared (ATR-FTIR) spectroscopy and protein identification via SDS-PAGE coupled with tandem mass spectrometry implied that dextrose as major carbon source in MRS played the most crucial role for L. rhamnosus production. Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

MTR and In-vivo 1H-MRS studies on mouse brain with parkinson's disease

NASA Astrophysics Data System (ADS)

Yoon, Moon-Hyun; Kim, Hyeon-Jin; Chung, Jin-Yeung; Doo, Ah-Reum; Park, Hi-Joon; Kim, Seung-Nam; Choe, Bo-Young

2012-12-01

The aim of this study was to investigate whether the changes in the magnetization transfer ratio (MTR) histogram are related to specific characteristics of Parkinson's disease (PD) and to investigate whether the MTR histogram parameters are associated with neurochemical dysfunction by performing in vivo proton magnetic resonance spectroscopy (1H-MRS). MTR and in vivo 1H-MRS studies were performed on control mice (n = 10) and 1-methyl-1,2,3,6-tetrahydropyridine intoxicated mice (n = 10). All the MTR and in vivo 1H-MRS experiments were performed on a 9.4 T MRI/MRS system (Bruker Biospin, Germany) using a standard head coil. The protondensity fast spin echo (FSE) images and the T2-weighted spin echo (SE) images were acquired with no gap. Outer volume suppression (OVS), combined with the ultra-short echo-time stimulated echo acquisition mode (STEAM), was used for the localized in-vivo 1H-MRS. The quantitative analysis of metabolites was performed from the 1H spectra obtained in vivo on the striatum (ST) by using jMRUI (Lyon, France). The peak height of the MTR histograms in the PD model group was significantly lower than that in the control group (p < 0.05). The midbrain MTR values for volume were lower in the PD group than the control group(p < 0.05). The complex peak (Glx: glutamine+glutamate+ GABA)/creatine (Cr) ratio of the right ST in the PD group was significantly increased as compared to that of the control group. The present study revealed that the peak height of the MTR histogram was significantly decreased in the ST and substantia nigra, and a significant increase in the Gl x /Cr ratio was found in the ST of the PD group, as compared with that of the control group. These findings could reflect the early phase of neuronal dysfunction of neurotransmitters.

The influence of local spring temperature variance on temperature sensitivity of spring phenology.

PubMed

Wang, Tao; Ottlé, Catherine; Peng, Shushi; Janssens, Ivan A; Lin, Xin; Poulter, Benjamin; Yue, Chao; Ciais, Philippe

2014-05-01

The impact of climate warming on the advancement of plant spring phenology has been heavily investigated over the last decade and there exists great variability among plants in their phenological sensitivity to temperature. However, few studies have explicitly linked phenological sensitivity to local climate variance. Here, we set out to test the hypothesis that the strength of phenological sensitivity declines with increased local spring temperature variance, by synthesizing results across ground observations. We assemble ground-based long-term (20-50 years) spring phenology database (PEP725 database) and the corresponding climate dataset. We find a prevalent decline in the strength of phenological sensitivity with increasing local spring temperature variance at the species level from ground observations. It suggests that plants might be less likely to track climatic warming at locations with larger local spring temperature variance. This might be related to the possibility that the frost risk could be higher in a larger local spring temperature variance and plants adapt to avoid this risk by relying more on other cues (e.g., high chill requirements, photoperiod) for spring phenology, thus suppressing phenological responses to spring warming. This study illuminates that local spring temperature variance is an understudied source in the study of phenological sensitivity and highlight the necessity of incorporating this factor to improve the predictability of plant responses to anthropogenic climate change in future studies. © 2013 John Wiley & Sons Ltd.

Tips for Staying Healthy While Traveling this Spring (and Summer, and Fall) | Poster

Cancer.gov

Spring is here again, and with it come scientific meetings and spring vacations. Some of the scientists and staff at NCI at Frederick will be traveling across the globe in the next few months, so Occupational Health Services would like to share a few tips for staying healthy while traveling.

Usefulness of the Obesity Surgery Mortality Risk Score (OR-MRS) in choosing the laparoscopic bariatric procedure.

PubMed

Orłowski, Mikołaj; Janik, Michał R; Paśnik, Krzysztof; Jędrzejewski, Emil

2015-07-01

The most popular scale to stratify the postoperative risk is the Obesity Surgery Mortality Risk Score (OS-MRS). The design and ease of interpretation make the scale a potential tool for clinical use. To evaluate the usefulness of the OS-MRS scale in the enrollment of patients for laparoscopic bariatric procedures, including laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB). The medical records of patients who underwent LSG or LRYGB due to obesity between January 2010 and December 2010 were reviewed retrospectively. The decision of choosing the surgical procedure was made on the basis of OS-MRS risk category. The primary endpoint of this study was the 90-day mortality, and the secondary endpoint was the presence of major complications. There were 107 patients including 66 women and 41 men. The OS-MRS classes were A (48%), B (47%) and C (5%). The LSG was applied to patients with higher body mass index and to patients of class C. The secondary endpoints occurred in 6 patients, distributed in 10% of class A, 2% of class B and 0% of class C patients (p < 0.05). In 5 of 6 cases the endpoint was observed after LRYGB. Fatal cases were not observed. The OS-MRS can be a useful clinical tool for choosing the appropriate laparoscopic bariatric procedure, depending on the risk of postoperative complications. Low risk of postoperative complications should not lower the watchfulness of the surgeon.

The RING Finger E3 Ligase SpRing is a Positive Regulator of Salt Stress Signaling in Salt-Tolerant Wild Tomato Species.

PubMed

Qi, Shilian; Lin, Qingfang; Zhu, Huishan; Gao, Fenghua; Zhang, Wenhao; Hua, Xuejun

2016-03-01

Protein ubiquitination in plants plays critical roles in many biological processes, including adaptation to abiotic stresses. Previously, RING finger E3 ligase has been characterized during salt stress response in several plant species, but little is known about its function in tomato. Here, we report that SpRing, a stress-inducible gene, is involved in salt stress signaling in wild tomato species Solanum pimpinellifolium 'PI365967'. In vitro ubiquitination assay revealed that SpRing is an E3 ubiquitin ligase and the RING finger conserved region is required for its activity. SpRing is expressed in all tissues of wild tomato and up-regulated by salt, drought and osmotic stresses, but repressed by low temperature. Green fluorescent protein (GFP) fusion analysis showed that SpRing is localized at the endoplasmic reticulum. Silencing of SpRing through a virus-induced gene silencing approach led to increased sensitivity to salt stress in wild tomato. Overexpression of SpRing in Arabidopsis thaliana resulted in enhanced salt tolerance during seed germination and early seedling development. The expression levels of certain key stress-related genes are altered both in SpRing-overexpressing Arabidopsis plants and virus-induced gene silenced tomato seedlings. Taken together, our results indicate that SpRing is involved in salt stress and functions as a positive regulator of salt tolerance. © The Author 2016. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Diffusion Weighted MRI and MRS to Differentiate Radiation Necrosis and Recurrent Disease in Gliomas

NASA Astrophysics Data System (ADS)

Ewell, Lars

2006-03-01

A difficulty encountered in the diagnosis of patients with gliomas is the differentiation between recurrent disease and Radiation Induced Necrosis (RIN). Both can appear as ‘enhancing lesions’ on a typical T2 weighted MRI scan. Magnetic Resonance Spectroscopy (MRS) and Diffusion Weighted MRI (DWMRI) have the potential to be helpful regarding this differentiation. MRS has the ability to measure the concentration of brain metabolites, such as Choline, Creatin and N- Acetyl Aspartate, the ratios of which have been shown to discriminate between RIN and recurrent disease. DWMRI has been linked via a rise in the Apparent Diffusion Coefficient (ADC) to successful treatment of disease. Using both of these complimentary non-invasive imaging modalities, we intend to initiate an imaging protocol whereby we will study how best to combine metabolite ratios and ADC values to obtain the most useful information in the least amount of scan time. We will look for correlations over time between ADC values, and MRS, among different sized voxels.

75 FR 23242 - International Whaling Commission; 62nd Annual Meeting; Announcement of Public Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-03

... be held in the NOAA Science Center Room, 1301 East-West Highway, Silver Spring, MD 20910. FOR FURTHER... posted on the IWC Secretariat's website at http://www.iwcoffice.org . NOAA will hold meetings prior to...., Seattle, WA 98115. The May 26 meeting will be held in the NOAA Science Center Room, 1301 East-West Highway...

APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study.

PubMed

Kuhla, Angela; Rühlmann, Claire; Lindner, Tobias; Polei, Stefan; Hadlich, Stefan; Krause, Bernd J; Vollmar, Brigitte; Teipel, Stefan J

2017-01-01

Transgenic animal models of Aβ pathology provide mechanistic insight into some aspects of Alzheimer disease (AD) pathology related to Aβ accumulation. Quantitative neuroimaging is a possible aid to improve translation of mechanistic findings in transgenic models to human end phenotypes of brain morphology or function. Therefore, we combined MRI-based morphometry, MRS-based NAA-assessment and quantitative histology of neurons and amyloid plaque load in the APPswe/PS1dE9 mouse model to determine the interrelationship between morphological changes, changes in neuron numbers and amyloid plaque load with reductions of NAA levels as marker of neuronal functional viability. The APPswe/PS1dE9 mouse showed an increase of Aβ plaques, loss of neurons and an impairment of NAA/Cr ratio, which however was not accompanied with brain atrophy. As brain atrophy is one main characteristic in human AD, conclusions from murine to human AD pathology should be drawn with caution.

Spring performance tester for miniature extension springs

DOEpatents

Salzbrenner, Bradley; Boyce, Brad

2017-05-16

A spring performance tester and method of testing a spring are disclosed that has improved accuracy and precision over prior art spring testers. The tester can perform static and cyclic testing. The spring tester can provide validation for product acceptance as well as test for cyclic degradation of springs, such as the change in the spring rate and fatigue failure.

Nucleotide-mediated relaxation in guinea-pig aorta: selective inhibition by MRS2179

PubMed Central

Kaiser, Robert A; Buxton, Iain L O

2002-01-01

The vasodilatory effects of nucleotides in the guinea-pig thoracic aorta were examined to determine the relationship between molecular expression and function of P2Y receptors. In aortic rings precontracted with norepinephrine, vasodilatory responses to purine nucleotides exhibited a rank-order of potency of 2-methylthio-ATP>ADP>ATP. Responses to UTP, but not UDP suggested a functional role for P2Y4 but not P2Y6 receptors. Aortic endothelial cells express at least four P2Y receptors; P2Y1, P2Y2, P2Y4 and P2Y6. In primary culture, these cells exhibit desensitizing transient calcium responses characteristic of P2Y1, P2Y2 and P2Y4, but not P2Y6 receptors. UDP had no effect on endothelial cell calcium. The pyrimidinergic receptor agonist UTP is capable of eliciting robust vasodilation in aortic rings and causing calcium responses in cultured guineapig aortic endothelial cells. These responses are equivalent to the maximum responses observed to ATP and ADP. Measurement of intracellular calcium release in response to ATP and 2-methylthio-ATP were similar, however only the 2-methylthio-ATP response was sensitive to the P2Y1 antagonist N6-methyl-2′-deoxyadenosine-3′,5′-bisphosphate (MRS2179). In aortic rings, vasodilatory responses to 2-methylthio-ATP, ATP and ADP were all blocked by pre-incubation of tissues with MRS2179. MRS2179 pretreatment had no effect of the ability of UTP to cause relaxation of norepinephrine responses in aortic rings or the ability of UTP to cause calcium release in aortic endothelial cells. We demonstrate robust effects of purine and pyrimidine nucleotides in guineapig aorta and provide functional and biochemical evidence that MRS2179 is a selective P2Y1 antagonist. PMID:11815389

All Ultra-High Vacuum In-Situ Growth & Processing Approaches to Realization of Semiconductor Nanostructure Arrays

DTIC Science & Technology

1997-05-15

Quantum Box/Dot, Strained Epitaxy , 3D islands, Patterned Substrates, Molecular Beam Epitaxy Focused Ion Beam , In-Situ Processing, Quantum Box Lasers...Grown on Planar and Patterned GaAs(100) Substrates by Molecular Beam Epitaxy ", J. Vac. Sei. Technol. B13, 642(1995) 5. A. Madhukar, P. Chen, Q. Xie...Formation and Vertical Self-Organization on GaAs(lOO) via Molecular Beam Epitaxy ", Paper presented at MRS Spring 󈨣 Meeting (Apr. 17-21, 1995, San

Evaluation of Cancer Metabolomics Using ex vivo High Resolution Magic Angle Spinning (HRMAS) Magnetic Resonance Spectroscopy (MRS)

PubMed Central

Fuss, Taylor L.; Cheng, Leo L.

2016-01-01

According to World Health Organization (WHO) estimates, cancer is responsible for more deaths than all coronary heart disease or stroke worldwide, serving as a major public health threat around the world. High resolution magic angle spinning (HRMAS) magnetic resonance spectroscopy (MRS) has demonstrated its usefulness in the identification of cancer metabolic markers with the potential to improve diagnosis and prognosis for the oncology clinic, due partially to its ability to preserve tissue architecture for subsequent histological and molecular pathology analysis. Capable of the quantification of individual metabolites, ratios of metabolites, and entire metabolomic profiles, HRMAS MRS is one of the major techniques now used in cancer metabolomic research. This article reviews and discusses literature reports of HRMAS MRS studies of cancer metabolomics published between 2010 and 2015 according to anatomical origins, including brain, breast, prostate, lung, gastrointestinal, and neuroendocrine cancers. These studies focused on improving diagnosis and understanding patient prognostication, monitoring treatment effects, as well as correlating with the use of in vivo MRS in cancer clinics. PMID:27011205

10 CFR 72.104 - Criteria for radioactive materials in effluents and direct radiation from an ISFSI or MRS.

Code of Federal Regulations, 2014 CFR

2014-01-01

... radiation from an ISFSI or MRS. 72.104 Section 72.104 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED... materials in effluents and direct radiation from an ISFSI or MRS. (a) During normal operations and... radioactive materials, radon and its decay products excepted, to the general environment, (2) Direct radiation...

10 CFR 72.104 - Criteria for radioactive materials in effluents and direct radiation from an ISFSI or MRS.

Code of Federal Regulations, 2012 CFR

2012-01-01

... radiation from an ISFSI or MRS. 72.104 Section 72.104 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED... materials in effluents and direct radiation from an ISFSI or MRS. (a) During normal operations and... radioactive materials, radon and its decay products excepted, to the general environment, (2) Direct radiation...

10 CFR 72.104 - Criteria for radioactive materials in effluents and direct radiation from an ISFSI or MRS.

Code of Federal Regulations, 2013 CFR

2013-01-01

... radiation from an ISFSI or MRS. 72.104 Section 72.104 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED... materials in effluents and direct radiation from an ISFSI or MRS. (a) During normal operations and... radioactive materials, radon and its decay products excepted, to the general environment, (2) Direct radiation...

Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics.

PubMed

Austdal, Marie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Skei, Bente; Mathew, Seema; Bjørge, Line; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte

2015-12-01

Preeclampsia is a heterogeneous gestational disease characterized by maternal hypertension and proteinuria, affecting 2-7% of pregnancies. The disorder is initiated by insufficient placental development, but studies characterizing the placental disease components are lacking. Our aim was to phenotype the preeclamptic placenta using high-resolution magic angle spinning nuclear magnetic resonance spectroscopy (HR-MAS MRS). Placental samples collected after delivery from women with preeclampsia (n = 19) and normotensive pregnancies (n = 15) were analyzed for metabolic biomarkers including amino acids, osmolytes, and components of the energy and phospholipid metabolism. The metabolic biomarkers were correlated to clinical characteristics and inflammatory biomarkers in the maternal sera. Principal component analysis showed inherent differences in placental metabolic profiles between preeclamptic and normotensive pregnancies. Significant differences in metabolic profiles were found between placentas from severe and non-severe preeclampsia, but not between preeclamptic pregnancies with fetal growth restricted versus normal weight neonates. The placental metabolites correlated with the placental stress marker sFlt-1 and triglycerides in maternal serum, suggesting variation in placental stress signaling between different placental phenotypes. HR-MAS MRS is a sensitive method for defining the placental disease component of preeclampsia, identifying several altered metabolic pathways. Placental HR-MAS MRS analysis may improve insight into processes affected in the preeclamptic placenta, and represents a novel long-required tool for a sensitive placental phenotyping of this heterogeneous disease. Copyright © 2015 Elsevier Ltd. All rights reserved.

Small RNA profiling in Mycobacterium tuberculosis identifies MrsI as necessary for an anticipatory iron sparing response.

PubMed

Gerrick, Elias R; Barbier, Thibault; Chase, Michael R; Xu, Raylin; François, Josie; Lin, Vincent H; Szucs, Matthew J; Rock, Jeremy M; Ahmad, Rushdy; Tjaden, Brian; Livny, Jonathan; Fortune, Sarah M

2018-06-19

One key to the success of Mycobacterium tuberculosis as a pathogen is its ability to reside in the hostile environment of the human macrophage. Bacteria adapt to stress through a variety of mechanisms, including the use of small regulatory RNAs (sRNAs), which posttranscriptionally regulate bacterial gene expression. However, very little is currently known about mycobacterial sRNA-mediated riboregulation. To date, mycobacterial sRNA discovery has been performed primarily in log-phase growth, and no direct interaction between any mycobacterial sRNA and its targets has been validated. Here, we performed large-scale sRNA discovery and expression profiling in M. tuberculosis during exposure to five pathogenically relevant stresses. From these data, we identified a subset of sRNAs that are highly induced in multiple stress conditions. We focused on one of these sRNAs, ncRv11846, here renamed mycobacterial regulatory sRNA in iron (MrsI). We characterized the regulon of MrsI and showed in mycobacteria that it regulates one of its targets, bfrA , through a direct binding interaction. MrsI mediates an iron-sparing response that is required for optimal survival of M. tuberculosis under iron-limiting conditions. However, MrsI is induced by multiple host-like stressors, which appear to trigger MrsI as part of an anticipatory response to impending iron deprivation in the macrophage environment. Copyright © 2018 the Author(s). Published by PNAS.

13C Mrs Studies of the Control of Hepatic Glycogen Metabolism at High Magnetic Fields

NASA Astrophysics Data System (ADS)

Miller, Corin O.; Cao, Jin; Zhu, He; Chen, Li M.; Wilson, George; Kennan, Richard; Gore, John C.

2017-06-01

Introduction: Glycogen is the primary intracellular storage form of carbohydrates. In contrast to most tissues where stored glycogen can only supply the local tissue with energy, hepatic glycogen is mobilized and released into the blood to maintain appropriate circulating glucose levels, and is delivered to other tissues as glucose in response to energetic demands. Insulin and glucagon, two current targets of high interest in the pharmaceutical industry, are well known glucose-regulating hormones whose primary effect in liver is to modulate glycogen synthesis and breakdown. The purpose of these studies was to develop methods to measure glycogen metabolism in real time non-invasively both in isolated mouse livers, and in non-human primates (NHPs) using 13C MRS. Methods: Livers were harvested from C57/Bl6 mice and perfused with [1-13C] Glucose. To demonstrate the ability to measure acute changes in glycogen metabolism ex-vivo, fructose, glucagon, and insulin were administered to the liver ex-vivo. The C1 resonance of glycogen was measured in real time with 13C MRS using an 11.7T (500 MHz) NMR spectrometer. To demonstrate the translatability of this approach, NHPs (male rhesus monkeys) were studied in a 7 T Philips MRI using a partial volume 1H/13C imaging coil. NPHs were subjected to a variable IV infusion of [1-13C] glucose (to maintain blood glucose at 3-4x basal), along with a constant 1 mg/kg/min infusion of fructose. The C1 resonance of glycogen was again measured in real time with 13C MRS. To demonstrate the ability to measure changes in glycogen metabolism in vivo, animals received a glucagon infusion (1 μg/kg bolus followed by 40 ng/kg/min constant infusion) half way through the study on the second study session. Results: In both perfused mouse livers and in NHPs, hepatic 13C-glycogen synthesis (i.e. monotonic increases in the 13C-glycogen NMR signal) was readily detected. In both paradigms, addition of glucagon resulted in cessation of glycogen synthesis

Modeling the effects of pumping wells in spring management: The case of Scirca spring (central Apennines, Italy)

NASA Astrophysics Data System (ADS)

Dragoni, W.; Mottola, A.; Cambi, C.

2013-06-01

wells far from the spring, the efficiency of the whole system can be optimized in terms of total withdrawal, drilling and management costs, with reduced environmental impact. The mathematical model also shows how long the system takes to regain its "undisturbed" state, with a tolerance of 0.5 l/s. The model highlights the possibility of forcing the system to supply a smaller amount of water in winter, in order to increase the summer yield. Such a management scheme, which can be applied to other springs, may be useful in better meeting the demand for water during dry seasons.

J-difference-edited MRS measures of γ-aminobutyric acid before and after acute caffeine administration.

PubMed

Oeltzschner, Georg; Zöllner, Helge J; Jonuscheit, Marc; Lanzman, Rotem S; Schnitzler, Alfons; Wittsack, Hans-Jörg

2018-05-12

The aim of this study was to investigate potential effects of acute caffeine intake on J-difference-edited MRS measures of the primary inhibitory neurotransmitter γ-aminobutyric acid (GABA). J-difference-edited Mescher-Garwood PRESS (MEGA-PRESS) and conventional PRESS data were acquired at 3T from voxels in the anterior cingulate and occipital area of the brain in 15 healthy subjects, before and after oral intake of a 200-mg caffeine dose. MEGA-PRESS data were analyzed with the MATLAB-based Gannet tool to estimate GABA+ macromolecule (GABA+) levels, while PRESS data were analyzed with LCModel to estimate levels of glutamate, glutamate+glutamine, N-acetylaspartate, and myo-inositol. All metabolites were quantified with respect to the internal reference compounds creatine and tissue water, and compared between the pre- and post-caffeine intake condition. For both MRS voxels, mean GABA+ estimates did not differ before and after caffeine intake. Slightly lower estimates of myo-inositol were observed after caffeine intake in both voxels. N-acetylaspartate, glutamate, and glutamate+glutamine did not show significant differences between conditions. Mean GABA+ estimates from J-difference-edited MRS in two different brain regions are not altered by acute oral administration of caffeine. These findings may increase subject recruitment efficiency for MRS studies. © 2018 International Society for Magnetic Resonance in Medicine.

Physical association and periodicity in quasar families with SDSS and 2MRS

NASA Astrophysics Data System (ADS)

Fulton, C. C.; Arp, H. C.; Hartnett, J. G.

2018-07-01

We have used the Sloan Digital Sky Survey (SDSS) data release 7 (DR7) and the 2MASS (Two Micron All Sky Survey) Redshift Survey (2MRS) Ks ≤11.75 mag data release to test for physical association of candidate companion quasars with putative parent galaxies by virtue of Karlsson periodicity in quasar redshifts. We conducted this analysis using the quasar family detection algorithm described in Fulton and Arp (Astrophys. J. 754:134, 2012) and used therein to analyze the 2dF Galaxy Redshift Survey (2dFGRS) and the 2dF Quasar Redshift Survey (2QZ). The SDSS and 2MRS data sets confirm the 2dF results and allow us to examine additional object behaviors also at high significance.

ACHP | News | Mrs. Laura Bush Announces Preserve America Community

Science.gov Websites

Sept. 15, 2003, Mobile, Alabama—Mrs. Laura Bush today announced details of two new key components of continue to build upon. Mobile is a great example of a community that is using its past to build a better recognition program included ACHP member Emily Summers; Mobile, AL, mayor Mike Dow; Secretary of the Interior

MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes.

PubMed

Broom, Kerry A; Anthony, Daniel C; Lowe, John P; Griffin, Julian L; Scott, Helen; Blamire, Andrew M; Styles, Peter; Perry, V Hugh; Sibson, Nicola R

2007-06-01

Prion diseases are fatal chronic neurodegenerative diseases. Previous qualitative magnetic resonance imaging (MRI) and spectroscopy (MRS) studies report conflicting results in the symptomatic stages of the disease, but little work has been carried out during the earlier stages of the disease. Here we have used the murine ME7 model of prion disease to quantitatively investigate MRI and MRS changes during the period prior to the onset of overt clinical signs (20+ weeks) and have correlated these with pathological and behavioural abnormalities. Using in vivo MRI, at the later stages of the preclinical period (18 weeks) the diffusion of tissue water was significantly reduced, coinciding with significant microglial activation and behavioural hyperactivity. Using in vivo MRS, we found early (12 weeks) decreases in the ratio of N-acetyl aspartate to both choline (NAA/Cho) and creatine (NAA/Cr) in the thalamus and hippocampus, which were associated with early behavioural deficits. Ex vivo MRS of brain extracts confirmed and extended these findings, showing early (8-12 weeks) decreases in both the neuronal metabolites NAA and glutamate, and the metabolic metabolites lactate and glucose. Increases in the glial metabolite myo-inositol were observed at later stages when microglial and astrocyte activation is substantial. These changes in MRI and MRS signals, which precede overt clinical signs of disease, could provide insights into the pathogenesis of this disease and may enable early detection of pathology.

The reproducibility of 31-phosphorus MRS measures of muscle energetics at 3 Tesla in trained men.

PubMed

Edwards, Lindsay M; Tyler, Damian J; Kemp, Graham J; Dwyer, Renee M; Johnson, Andrew; Holloway, Cameron J; Nevill, Alan M; Clarke, Kieran

2012-01-01

Magnetic resonance spectroscopy (MRS) provides an exceptional opportunity for the study of in vivo metabolism. MRS is widely used to measure phosphorus metabolites in trained muscle, although there are no published data regarding its reproducibility in this specialized cohort. Thus, the aim of this study was to assess the reproducibility of (31)P-MRS in trained skeletal muscle. We recruited fifteen trained men (VO(2)peak = 4.7±0.8 L min(-1)/58±8 mL kg(-1) min(-1)) and performed duplicate MR experiments during plantar flexion exercise, three weeks apart. Measures of resting phosphorus metabolites were reproducible, with 1.7 mM the smallest detectable difference in phosphocreatine (PCr). Measures of metabolites during exercise were less reliable: exercising PCr had a coefficient of variation (CV) of 27% during exercise, compared with 8% at rest. Estimates of mitochondrial function were variable, but experimentally useful. The CV of PCr(1/2t) was 40%, yet much of this variance was inter-subject such that differences of <20% were detectable with n = 15, given a significance threshold of p<0.05. 31-phosphorus MRS provides reproducible and experimentally useful measures of phosphorus metabolites and mitochondrial function in trained human skeletal muscle.

Mrs. Haise in viewing room overlooking FCR

NASA Image and Video Library

1970-04-14

S70-34900 (14 April 1970) --- Mrs. Mary Haise receives an explanation of the revised flight plan of the Apollo 13 mission from astronaut Gerald P. Carr in the viewing room of the Mission Control Center (MCC), Building 30, at the Manned Spacecraft Center (MSC). Her husband, astronaut Fred W. Haise Jr., lunar module pilot for the Apollo 13 mission, was joining fellow crew members, astronauts James A. Lovell Jr., and John L. Swigert Jr. in making correction in their spacecraft following discovery of an oxygen cell failure several hours earlier.

Hood River Production Program Monitoring and Evaluation (M&E) - Confederated Tribes of Warm Springs : Annual Report For Fiscal Year, October 2007 – September 2008.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gerstenberger, Ryan

2009-07-27

This progress report describes work performed by the Confederated Tribes of Warm Springs (CTWSRO) portion of the Hood River Production Program Monitoring and Evaluation Project (HRPP) during the 2008 fiscal year. A total of 64,736 hatchery winter steelhead, 12,108 hatchery summer steelhead, and 68,426 hatchery spring Chinook salmon smolts were acclimated and released in the Hood River basin during the spring. The HRPP exceeded program goals for a release of and 50,000 winter steelhead but fell short of the steelhead release goals of 30,000 summer steelhead and 75,000 spring Chinook in 2008. Passive Integrated Transponders (PIT) tags were implanted inmore » 6,652 hatchery winter steelhead, and 1,196 hatchery summer steelhead, to compare migratory attributes and survival rates of hatchery fish released into the Hood River. Water temperatures were recorded at six locations within the Hood River subbasin to monitor for compliance with Oregon Department of Environmental Quality water quality standards. A preseason spring Chinook salmon adult run forecast was generated, which predicted an abundant return adequate to meet escapement goal and brood stock needs. As a result the tribal and sport fisheries were opened. A tribal creel was conducted from May 22 to July 18 during which an estimated 172 spring Chinook were harvested. One hundred sixteen Spring Chinook salmon redds were observed and 72 carcasses were inspected on 19.4 miles of spawning grounds throughout the Hood River Basin during 2008. Annual salvage operations were completed in two irrigation canals resulting in the liberation of 1,641 fish back to the Hood River.« less

Nutrition Frontiers - Spring 2018 | Division of Cancer Prevention

Cancer.gov

Dear Colleague, The spring issue of Nutrition Frontiers showcases the association of gut microbial communities in premenopausal women, how high-fat, high-calorie-diet-induced obesity may increase pancreatic cancer, and the effects of calorie restriction protocols on pro-inflammatory cytokines. Meet our spotlight investigator, Dr. Purnima Kumar, and her research on black

Abstracts of papers presented at the LVIII Cold Spring Harbor Symposium on quantitative Biology: DNA and chromosomes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This volume contains the abstracts of oral and poster presentations made at the LVIII Cold Spring Harbor Symposium on Quantitative Biology entitles DNA & Chromosomes. The meeting was held June 2--June 9, 1993 at Cold Spring Harbor, New York.

In VivoQuantitation of Cerebral Metabolite Concentrations Using Natural Abundance 13C MRS at 1.5 T

NASA Astrophysics Data System (ADS)

Blüml, Stefan

1999-02-01

A method for the quantitation of cerebral metabolites on a clinical MR scanner by natural abundance13C MRSin vivois described. Proton-decoupled spectra were acquired with a power deposition within FDA guidelines using a novel coil design.myo-Inositol, quantified by a separate proton MRS, and readily detectable in13C MRS, was used as an internal reference. Normal concentrations, measured in four control subjects, age 7 months to 12 years, were glutamate 9.9 ± 0.7, glutamine 5.6 ± 1.0, and NAA 8.8 ± 2.8 mmol/kg. In a patient diagnosed with Canavan disease, examined four times, glutamate was reduced to 46% of normal, 4.6 ± 0.5 mmol/kg. NAA was increased by 50% to 13.2 ± 1.6 mmol/kg in13C MRS, consistent with the 41% increase to 12.3 ± 1.1 from control 8.7 ± 1.1 mmol/kg assayed by1H MRS. Limited concentration of glutamate may impact on glutamatergic neurons and excitatory neurotransmission in Canavan disease. Quantitation of cerebral glutamate in human brain may have clinical value in human neuropathologies in which glutamate is believed to play a central role.

Resting functional imaging tools (MRS, SPECT, PET and PCT).

PubMed

Van Der Naalt, J

2015-01-01

Functional imaging includes imaging techniques that provide information about the metabolic and hemodynamic status of the brain. Most commonly applied functional imaging techniques in patients with traumatic brain injury (TBI) include magnetic resonance spectroscopy (MRS), single photon emission computed tomography (SPECT), positron emission tomography (PET) and perfusion CT (PCT). These imaging modalities are used to determine the extent of injury, to provide information for the prediction of outcome, and to assess evidence of cerebral ischemia. In TBI, secondary brain damage mainly comprises ischemia and is present in more than 80% of fatal cases with traumatic brain injury (Graham et al., 1989; Bouma et al., 1991; Coles et al., 2004). In particular, while SPECT measures cerebral perfusion and MRS determines metabolism, PET is able to assess both perfusion and cerebral metabolism. This chapter will describe the application of these techniques in traumatic brain injury separately for the major groups of severity comprising the mild and moderate to severe group. The application in TBI and potential difficulties of each technique is described. The use of imaging techniques in children will be separately outlined. © 2015 Elsevier B.V. All rights reserved.

RTO Highlights 2000

DTIC Science & Technology

2001-05-01

France, which the Board visited during its Spring 2000 meeting. A photographic report of the visit to the Centre is given elsewhere in this issue. The...right in this photo taken at Orly Airport when they left Paris in July 1973. More recent photographs of Mike and Lana appear on pages 35 and 43. The New...taken part in a rifle-shooting competition which was won by Mrs Rosaria Salzano, the wife of the SET Executive. It is hoped that these photographs , mainly

75 FR 65376 - Chesapeake and Ohio Canal National Historical Park Advisory Commission; Notice of Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-22

... National Historical Park Advisory Commission will be held at 9:30 a.m., on Friday, November 5, 2010, at... withhold your personal identifying information from public review, we cannot guarantee that we will be able.... Charles J. Weir Mr. Barry A. Passett Mr. James G. McCleaf II Mr. John A. Ziegler Mrs. Mary E. Woodward Mrs...

High-resolution measurements of the DT neutron spectrum using new CD foils in the Magnetic Recoil neutron Spectrometer (MRS) on the National Ignition Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gatu Johnson, M., E-mail: gatu@psfc.mit.edu; Frenje, J. A.; Li, C. K.

2016-11-15

The Magnetic Recoil neutron Spectrometer (MRS) on the National Ignition Facility measures the DT neutron spectrum from cryogenically layered inertial confinement fusion implosions. Yield, areal density, apparent ion temperature, and directional fluid flow are inferred from the MRS data. This paper describes recent advances in MRS measurements of the primary peak using new, thinner, reduced-area deuterated plastic (CD) conversion foils. The new foils allow operation of MRS at yields 2 orders of magnitude higher than previously possible, at a resolution down to ∼200 keV FWHM.

High-resolution measurements of the DT neutron spectrum using new CD foils in the Magnetic Recoil neutron Spectrometer (MRS) on the National Ignition Facility

DOE PAGES

Gatu Johnson, M.; Frenje, J. A.; Bionta, R. M.; ...

2016-08-09

The Magnetic Recoil neutron Spectrometer (MRS) on the National Ignition Facility measures the DT neutron spectrum from cryogenically layered inertial confinement fusion implosions. Yield, areal density, apparent ion temperature, and directional fluid flow are inferred from the MRS data. Here, this paper describes recent advances in MRS measurements of the primary peak using new, thinner, reduced-area deuterated plastic (CD) conversion foils. The new foils allow operation of MRS at yields 2 orders of magnitude higher than previously possible, at a resolution down to ~200 keV FWHM.

High-resolution measurements of the DT neutron spectrum using new CD foils in the Magnetic Recoil neutron Spectrometer (MRS) on the National Ignition Facility.

PubMed

Gatu Johnson, M; Frenje, J A; Bionta, R M; Casey, D T; Eckart, M J; Farrell, M P; Grim, G P; Hartouni, E P; Hatarik, R; Hoppe, M; Kilkenny, J D; Li, C K; Petrasso, R D; Reynolds, H G; Sayre, D B; Schoff, M E; Séguin, F H; Skulina, K; Yeamans, C B

2016-11-01

The Magnetic Recoil neutron Spectrometer (MRS) on the National Ignition Facility measures the DT neutron spectrum from cryogenically layered inertial confinement fusion implosions. Yield, areal density, apparent ion temperature, and directional fluid flow are inferred from the MRS data. This paper describes recent advances in MRS measurements of the primary peak using new, thinner, reduced-area deuterated plastic (CD) conversion foils. The new foils allow operation of MRS at yields 2 orders of magnitude higher than previously possible, at a resolution down to ∼200 keV FWHM.

Aqua/Aura Inclination Adjust Maneuver Series Spring 2018 Planning

NASA Technical Reports Server (NTRS)

Trenholme, Elena; Boone, Spencer

2017-01-01

This will be presented at the International Earth Science Constellation Mission Operations Working Group meeting on December 6-8, 2017 to discuss the Aqua/Aura Spring 2018 Inclination Adjust Maneuver series planning. Presentation has been reviewed and approved by Eric Moyer, ESMO (Earth Science Mission Operations) Deputy Project Manager.

Advanced processing and simulation of MRS data using the FID appliance (FID-A)-An open source, MATLAB-based toolkit.

PubMed

Simpson, Robin; Devenyi, Gabriel A; Jezzard, Peter; Hennessy, T Jay; Near, Jamie

2017-01-01

To introduce a new toolkit for simulation and processing of magnetic resonance spectroscopy (MRS) data, and to demonstrate some of its novel features. The FID appliance (FID-A) is an open-source, MATLAB-based software toolkit for simulation and processing of MRS data. The software is designed specifically for processing data with multiple dimensions (eg, multiple radiofrequency channels, averages, spectral editing dimensions). It is equipped with functions for importing data in the formats of most major MRI vendors (eg, Siemens, Philips, GE, Agilent) and for exporting data into the formats of several common processing software packages (eg, LCModel, jMRUI, Tarquin). This paper introduces the FID-A software toolkit and uses examples to demonstrate its novel features, namely 1) the use of a spectral registration algorithm to carry out useful processing routines automatically, 2) automatic detection and removal of motion-corrupted scans, and 3) the ability to perform several major aspects of the MRS computational workflow from a single piece of software. This latter feature is illustrated through both high-level processing of in vivo GABA-edited MEGA-PRESS MRS data, as well as detailed quantum mechanical simulations to generate an accurate LCModel basis set for analysis of the same data. All of the described processing steps resulted in a marked improvement in spectral quality compared with unprocessed data. Fitting of MEGA-PRESS data using a customized basis set resulted in improved fitting accuracy compared with a generic MEGA-PRESS basis set. The FID-A software toolkit enables high-level processing of MRS data and accurate simulation of in vivo MRS experiments. Magn Reson Med 77:23-33, 2017. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

(1)H-magnetic resonance spectroscopy ((1)H-MRS) in methamphetamine dependence and methamphetamine induced psychosis.

PubMed

Howells, Fleur M; Uhlmann, Anne; Temmingh, Henk; Sinclair, Heidi; Meintjes, Ernesta; Wilson, Don; Stein, Dan J

2014-03-01

Methamphetamine (MA) use has been shown to decrease n-acetyl-aspartate (NAA), a marker of neuronal integrity and viability, on (1)H magnetic resonance spectroscopy ((1)H-MRS). However, little work has compared (1)H-MRS in MA dependent individuals and MA dependent individuals with MA induced psychotic disorder (MAP). Twenty six participants with MA dependence (sixteen without psychosis, ten with psychosis - MAP) and nineteen healthy controls underwent 2D-chemical shift imaging (1)H-MRS, which included voxels in the anterior cingulate cortices (ACC), dorsolateral prefrontal cortices (DLPFC), and frontal white matter. We compared metabolite concentrations relative to phosphocreatine+creatine (PCr+Cr) for n-acetyl-aspartate (NAA), n-acetyl-aspartate+n-acetyl-aspartyl-glutamate (NAA+NAAG), glutamate (Glu), glutamate+glutamine (Glu+Gln), myo-inositol, and glycerophosphocholine+phosphocholine (GPC+PCh) across groups. The MA groups showed significantly decreased relative NAA metabolite concentrations for right ACC and right DLPFC, compared with control group. The MA dependent group only showed significantly decreased choline metabolites for right DLPFC, compared with control group. The MAP group's relative NAA metabolite concentrations were significantly correlated with age of initial use and duration of MA use, these correlates were not apparent in MA dependent group. MA use is associated with decreased neuronal integrity and viability, specifically in the right ACC and right DLPFC. MA dependence showed active neurodegeneration in the right DLPFC, this was not apparent in the MAP group and may be related to the use of antipsychotic medication in the MAP group. The effects of MA use in MAP suggest that age of initial use presents a mismatch of neuronal plasticity, in frontal white vs. gray matter and duration of use relates to decreased neuronal integrity and viability. Further study is warranted from this initial study of (1)H-MRS in MAP, in particular longitudinal

Nutrition Frontiers - Spring 2017 | Division of Cancer Prevention

Cancer.gov

Volume 8, Issue 2 Dear Colleague, The spring issue of Nutrition Frontiers showcases the calcium/magnesium intake ratio in colorectal adenoma, the role of PPARγ in metabolism and reproduction, and the effects of time-restricted feeding on metabolic parameters. Meet our spotlight investigator, Dr. Maria Cruz-Correa, and her research on gut bacterial genes, diet, and colorectal

Finite element fatigue analysis of rectangular clutch spring of automatic slack adjuster

NASA Astrophysics Data System (ADS)

Xu, Chen-jie; Luo, Zai; Hu, Xiao-feng; Jiang, Wen-song

2015-02-01

The failure of rectangular clutch spring of automatic slack adjuster directly affects the work of automatic slack adjuster. We establish the structural mechanics model of automatic slack adjuster rectangular clutch spring based on its working principle and mechanical structure. In addition, we upload such structural mechanics model to ANSYS Workbench FEA system to predict the fatigue life of rectangular clutch spring. FEA results show that the fatigue life of rectangular clutch spring is 2.0403×105 cycle under the effect of braking loads. In the meantime, fatigue tests of 20 automatic slack adjusters are carried out on the fatigue test bench to verify the conclusion of the structural mechanics model. The experimental results show that the mean fatigue life of rectangular clutch spring is 1.9101×105, which meets the results based on the finite element analysis using ANSYS Workbench FEA system.

The Meeting of the Americas

NASA Astrophysics Data System (ADS)

Bates, John; Fucugauchi, Jaime Urrutia

2008-05-01

The AGU Joint Assembly, previously known as the Spring Meeting, has formally adopted the designation ``The Meeting of the Americas.'' This designation reflects the objective of the Joint Assembly to promote cooperative efforts among Earth and science societies in the Americas. To achieve this objective, future Joint Assembly locations will rotate among different cities in the United States, Canada, and Latin America; the Program Committee includes representatives from throughout the Americas; and the meetings will be convened jointly with scientific societies throughout the Americas.

(1)H MRS: a potential biomarker of in utero placental function.

PubMed

Macnaught, Gillian; Gray, Calum; Walker, Jane; Simpson, Mary; Norman, Jane; Semple, Scott; Denison, Fiona

2015-10-01

The placenta is a temporary organ that is essential for a healthy pregnancy. It performs several important functions, including the transport of nutrients, the removal of waste products and the metabolism of certain substances. Placental disorders have been found to account for over 50% of stillbirths. Despite this, there are currently no methods available to directly and non-invasively assess placental function in utero. The primary aim of this pilot study was to investigate the use of (1)H MRS for this purpose. (1)H MRS offers the possibility to detect several placental metabolites, including choline, lipids and the amino acids glutamine and glutamate (Glx), which are vital to fetal development and placental function. Here, in utero placental spectra were acquired from nine small for gestational age (SGA) pregnancies, a cohort who are at increased risk of perinatal morbidity and mortality, and from nine healthy gestation-matched pregnancies. All subjects were between 26 and 39 weeks of gestation. Placenta Glx, choline and lipids at 1.3 and 0.9 ppm were quantified as amplitude ratios to that of intrinsic H2O. Wilcoxon signed rank tests indicated a significant difference in Glx/H2O (p = 0.024) between the two groups, but not in choline/H2O (p = 0.722) or in either lipid/H2O ratio (1.3 ppm, p = 0.813; 0.9 ppm, p = 0.058). This study has demonstrated that (1)H MRS has potential for the detection of placental metabolites in utero. This warrants further investigation as a tool for the monitoring of placental function. Copyright © 2015 John Wiley & Sons, Ltd.

Occipital cortical proton MRS at 4 Tesla in human moderate MDMA polydrug users

PubMed Central

Cowan, Ronald L.; Bolo, Nicolas R.; Dietrich, Mary; Haga, Erica; Lukas, Scott E.; Renshaw, Perry F.

2007-01-01

The recreational drug MDMA (3,4, methylenedioxymethamphetamine; sold under the street name of Ecstasy) is toxic to serotonergic axons in some animal models of MDMA administration. In humans, MDMA use is associated with alterations in markers of brain function that are pronounced in occipital cortex. Among neuroimaging methods, magnetic resonance spectroscopy (MRS) studies of brain metabolites N-acetylaspartate (NAA) and myoinositol (MI) at a field strength of 1.5 Tesla (T) reveal inconsistent results in MDMA users. Because higher field strength proton MRS has theoretical advantages over lower field strengths, we used proton MRS at 4.0 T to study absolute concentrations of occipital cortical NAA and MI in a cohort of moderate MDMA users (n = 9) versus non-MDMA using (n = 7) controls. Mean NAA in non-MDMA users was 10.47 mM (± 2.51), versus 9.83 mM (± 1.94) in MDMA users. Mean MI in non-MDMA users was 7.43 mM (± 1.68), versus 6.57 mM (± 1.59) in MDMA users. There were no statistical differences in absolute metabolite levels for NAA and MI in occipital cortex of MDMA users and controls. These findings are not supportive of MDMA-induced alterations in NAA or MI levels in this small sample of moderate MDMA users. Limitations to this study suggest caution in the interpretation of these results. PMID:17574394

Occipital cortical proton MRS at 4 Tesla in human moderate MDMA polydrug users.

PubMed

Cowan, Ronald L; Bolo, Nicolas R; Dietrich, Mary; Haga, Erica; Lukas, Scott E; Renshaw, Perry F

2007-08-15

The recreational drug MDMA (3,4, methylenedioxymethamphetamine; sold under the street name of Ecstasy) is toxic to serotonergic axons in some animal models of MDMA administration. In humans, MDMA use is associated with alterations in markers of brain function that are pronounced in occipital cortex. Among neuroimaging methods, magnetic resonance spectroscopy (MRS) studies of brain metabolites N-acetylaspartate (NAA) and myoinositol (MI) at a field strength of 1.5 Tesla (T) reveal inconsistent results in MDMA users. Because higher field strength proton MRS has theoretical advantages over lower field strengths, we used proton MRS at 4.0 T to study absolute concentrations of occipital cortical NAA and MI in a cohort of moderate MDMA users (n=9) versus non-MDMA using (n=7) controls. Mean NAA in non-MDMA users was 10.47 mM (+/-2.51), versus 9.83 mM (+/-1.94) in MDMA users. Mean MI in non-MDMA users was 7.43 mM (+/-.68), versus 6.57 mM (+/-1.59) in MDMA users. There were no statistical differences in absolute metabolite levels for NAA and MI in occipital cortex of MDMA users and controls. These findings are not supportive of MDMA-induced alterations in NAA or MI levels in this small sample of moderate MDMA users. Limitations to this study suggest caution in the interpretation of these results.

Mrs. Chandrasekhar poses with contest winners

NASA Technical Reports Server (NTRS)

1999-01-01

Mrs. Lalitha Chandrasekhar (left), wife of the late Indian- American Nobel Laureate Subrahmanyan Chandrasekhar, poses with a model of the Chandra X-ray Observatory and the winners of the contest to rename the telescope in the TRW Media Hospitality Tent at the NASA Press Site at KSC. The winners of the contest are Jatila van der Veen (center), academic coordinator and lecturer, Physics Dept., University of Santa Barbara, Calif., and Tyrel Johnson (right), high school student, Laclede, Idaho. The name 'Chandra,' a shortened version of Chandrasekhar's name which he preferred among friends and colleagues, was chosen to honor the Nobel Laureate. 'Chandra' also means 'Moon' or 'luminous' in Sanskrit. The observatory is scheduled to be launched aboard Columbia on Space Shuttle mission STS-93.

Non-negative matrix factorisation methods for the spectral decomposition of MRS data from human brain tumours

PubMed Central

2012-01-01

Background In-vivo single voxel proton magnetic resonance spectroscopy (SV 1H-MRS), coupled with supervised pattern recognition (PR) methods, has been widely used in clinical studies of discrimination of brain tumour types and follow-up of patients bearing abnormal brain masses. SV 1H-MRS provides useful biochemical information about the metabolic state of tumours and can be performed at short (< 45 ms) or long (> 45 ms) echo time (TE), each with particular advantages. Short-TE spectra are more adequate for detecting lipids, while the long-TE provides a much flatter signal baseline in between peaks but also negative signals for metabolites such as lactate. Both, lipids and lactate, are respectively indicative of specific metabolic processes taking place. Ideally, the information provided by both TE should be of use for clinical purposes. In this study, we characterise the performance of a range of Non-negative Matrix Factorisation (NMF) methods in two respects: first, to derive sources correlated with the mean spectra of known tissue types (tumours and normal tissue); second, taking the best performing NMF method for source separation, we compare its accuracy for class assignment when using the mixing matrix directly as a basis for classification, as against using the method for dimensionality reduction (DR). For this, we used SV 1H-MRS data with positive and negative peaks, from a widely tested SV 1H-MRS human brain tumour database. Results The results reported in this paper reveal the advantage of using a recently described variant of NMF, namely Convex-NMF, as an unsupervised method of source extraction from SV1H-MRS. Most of the sources extracted in our experiments closely correspond to the mean spectra of some of the analysed tumour types. This similarity allows accurate diagnostic predictions to be made both in fully unsupervised mode and using Convex-NMF as a DR step previous to standard supervised classification. The obtained results are comparable to, or

Conference Proceedings. Defense Modeling and Simulation Office Information/Data Base (I/DB) Task Group Meetings Held February 14-18, 1994, and Notes from the Previous Two I/DB Meetings

DTIC Science & Technology

1994-01-01

DB Task Group co-chairs would like to thank Mrs. Janice Hirst of IDA for her help in coordinating and supporting the I/DBTG meetings and Ms. Linda ...Data (co-chairs Len Seligman (Mitre) and Pete Valentine (Army/JDBE)): will start with several recent categorization attempts including those offered in...fbrmed to address categorization of complex data co-chaired by Len Seligman (Mitre) and Pete Valentine (Army/JDBE)); (2) a subgroup to deal with

Development and Validation of the Nursing Home Minimum Data Set 3.0 Mortality Risk Score (MRS3).

PubMed

Thomas, Kali S; Ogarek, Jessica A; Teno, Joan M; Gozalo, Pedro L; Mor, Vincent

2018-03-05

To develop a score to predict mortality using the Minimum Data Set 3.0 (MDS 3.0) that can be readily calculated from items collected during nursing home (NH) residents' admission assessments. We developed a training cohort of Medicare beneficiaries newly admitted to U.S. NHs during 2012 (N=1,426,815) and a testing cohort from 2013 (N=1,160,964). Data came from the MDS 3.0 assessments linked to the Medicare Beneficiary Summary File. Using the training dataset, we developed a composite MDS 3.0 Mortality Risk Score (MRS3) consisting of 17 clinical items and patients' age groups based on their relation to 30-day mortality. We assessed the calibration and discrimination of the MRS3 in predicting 30-day and 60-day mortality and compared its performance to the Charlson Comorbidity Index and the clinician's assessment of 6-month prognosis measured at admission. The 30-day and 60-day mortality rate for the testing population was 2.8% and 5.6%, respectively. Results from logistic regression models suggest that the MRS3 performed well in predicting death within 30 and 60 days (C-Statistics of 0.744 (95%CL = 0.741, 0.747) and 0.709 (95%CL=0.706, 0.711), respectively). The MRS3 was a superior predictor of mortality compared to the Charlson Comorbidity Index (C-statistics of 0.611 (95%CL=0.607, 0.615) and 0.608 (95%CL=0.605, 0.610)) and the clinicians' assessments of patients' 6-month prognoses (C-statistics of 0.543 (95%CL=0.542, 0.545) and 0.528 (95%CL=0.527, 0.529). The MRS3 is a good predictor of mortality and can be useful in guiding decision-making, informing plans of care, and adjusting for patients' risk of mortality.

Applying spatial analysis techniques to assess the suitability of multipurpose uses of spring water in the Jiaosi Hot Spring Region, Taiwan.

PubMed

Jang, Cheng-Shin; Huang, Han-Chen

2017-07-01

The Jiaosi Hot Spring Region is one of the most famous tourism destinations in Taiwan. The spring water is processed for various uses, including irrigation, aquaculture, swimming, bathing, foot spas, and recreational tourism. Moreover, the multipurpose uses of spring water can be dictated by the temperature of the water. To evaluate the suitability of spring water for these various uses, this study spatially characterized the spring water temperatures of the Jiaosi Hot Spring Region by integrating ordinary kriging (OK), sequential Gaussian simulation (SGS), and Geographic information system (GIS). First, variogram analyses were used to determine the spatial variability of spring water temperatures. Next, OK and SGS were adopted to model the spatial uncertainty and distributions of the spring water temperatures. Finally, the land use (i.e., agriculture, dwelling, public land, and recreation) was determined using GIS and combined with the estimated distributions of the spring water temperatures. A suitable development strategy for the multipurpose uses of spring water is proposed according to the integration of the land use and spring water temperatures. The study results indicate that the integration of OK, SGS, and GIS is capable of characterizing spring water temperatures and the suitability of multipurpose uses of spring water. SGS realizations are more robust than OK estimates for characterizing spring water temperatures compared to observed data. Furthermore, current land use is almost ideal in the Jiaosi Hot Spring Region according to the estimated spatial pattern of spring water temperatures.

Efficient full decay inversion of MRS data with a stretched-exponential approximation of the ? distribution

NASA Astrophysics Data System (ADS)

Behroozmand, Ahmad A.; Auken, Esben; Fiandaca, Gianluca; Christiansen, Anders Vest; Christensen, Niels B.

2012-08-01

We present a new, efficient and accurate forward modelling and inversion scheme for magnetic resonance sounding (MRS) data. MRS, also called surface-nuclear magnetic resonance (surface-NMR), is the only non-invasive geophysical technique that directly detects free water in the subsurface. Based on the physical principle of NMR, protons of the water molecules in the subsurface are excited at a specific frequency, and the superposition of signals from all protons within the excited earth volume is measured to estimate the subsurface water content and other hydrological parameters. In this paper, a new inversion scheme is presented in which the entire data set is used, and multi-exponential behaviour of the NMR signal is approximated by the simple stretched-exponential approach. Compared to the mono-exponential interpretation of the decaying NMR signal, we introduce a single extra parameter, the stretching exponent, which helps describe the porosity in terms of a single relaxation time parameter, and helps to determine correct initial amplitude and relaxation time of the signal. Moreover, compared to a multi-exponential interpretation of the MRS data, the decay behaviour is approximated with considerably fewer parameters. The forward response is calculated in an efficient numerical manner in terms of magnetic field calculation, discretization and integration schemes, which allows fast computation while maintaining accuracy. A piecewise linear transmitter loop is considered for electromagnetic modelling of conductivities in the layered half-space providing electromagnetic modelling of arbitrary loop shapes. The decaying signal is integrated over time windows, called gates, which increases the signal-to-noise ratio, particularly at late times, and the data vector is described with a minimum number of samples, that is, gates. The accuracy of the forward response is investigated by comparing a MRS forward response with responses from three other approaches outlining

Muscle MRS detects elevated PDE/ATP ratios prior to fatty infiltration in Becker muscular dystrophy.

PubMed

Wokke, B H; Hooijmans, M T; van den Bergen, J C; Webb, A G; Verschuuren, J J; Kan, H E

2014-11-01

Becker muscular dystrophy (BMD) is characterized by progressive muscle weakness. Muscles show structural changes (fatty infiltration, fibrosis) and metabolic changes, both of which can be assessed using MRI and MRS. It is unknown at what stage of the disease process metabolic changes arise and how this might vary for different metabolites. In this study we assessed metabolic changes in skeletal muscles of Becker patients, both with and without fatty infiltration, quantified via Dixon MRI and (31) P MRS. MRI and (31) P MRS scans were obtained from 25 Becker patients and 14 healthy controls using a 7 T MR scanner. Five lower-leg muscles were individually assessed for fat and muscle metabolite levels. In the peroneus, soleus and anterior tibialis muscles with non-increased fat levels, PDE/ATP ratios were higher (P < 0.02) compared with controls, whereas in all muscles with increased fat levels PDE/ATP ratios were higher compared with healthy controls (P ≤ 0.05). The Pi /ATP ratio in the peroneus muscles was higher in muscles with increased fat fractions (P = 0.005), and the PCr/ATP ratio was lower in the anterior tibialis muscles with increased fat fractions (P = 0.005). There were no other significant changes in metabolites, but an increase in tissue pH was found in all muscles of the total group of BMD patients in comparison with healthy controls (P < 0.05). These findings suggest that (31) P MRS can be used to detect early changes in individual muscles of BMD patients, which are present before the onset of fatty infiltration. Copyright © 2014 John Wiley & Sons, Ltd.

13C MRS of Human Brain at 7 Tesla Using [2-13C]Glucose Infusion and Low Power Broadband Stochastic Proton Decoupling

PubMed Central

Li, Shizhe; An, Li; Yu, Shao; Araneta, Maria Ferraris; Johnson, Christopher S.; Wang, Shumin; Shen, Jun

2015-01-01

Purpose 13C magnetic resonance spectroscopy (MRS) of human brain at 7 Tesla (T) may pose patient safety issues due to high RF power deposition for proton decoupling. The purpose of present work is to study the feasibility of in vivo 13C MRS of human brain at 7 T using broadband low RF power proton decoupling. Methods Carboxylic/amide 13C MRS of human brain by broadband stochastic proton decoupling was demonstrated on a 7 T scanner. RF safety was evaluated using the finite-difference time-domain method. 13C signal enhancement by nuclear Overhauser effect (NOE) and proton decoupling was evaluated in both phantoms and in vivo. Results At 7 T, the peak amplitude of carboxylic/amide 13C signals was increased by a factor of greater than 4 due to the combined effects of NOE and proton decoupling. The 7 T 13C MRS technique used decoupling power and average transmit power of less than 35 W and 3.6 W, respectively. Conclusion In vivo 13C MRS studies of human brain can be performed at 7 T well below the RF safety threshold by detecting carboxylic/amide carbons with broadband stochastic proton decoupling. PMID:25917936

19th JANNAF Safety and Environmental Protection Subcommittee Meeting. Volume 1

NASA Technical Reports Server (NTRS)

Cocchiaro, J. E. (Editor); Becker, D. L. (Editor)

2002-01-01

This volume, the first of two volumes, is a compilation of 22 unclassified/unlimited technical papers presented at the 19th Joint Army-Navy-NASA-Air Force (JANNAF) Safety & Environmental Protection Subcommittee Meeting. The meeting was held 18-21 March 2002 at the Sheraton Colorado Springs Hotel, Colorado Springs, Colorado. Topics covered include green energetic materials and life cycle pollution prevention; space launch range safety; propellant/munitions demilitarization, recycling, and reuse: and environmental and occupational health aspects of propellants and energetic materials.

Postictal in situ MRS brain lactate in the rat kindling model.

PubMed

Maton, B M; Najm, I M; Wang, Y; Lüders, H O; Ng, T C

1999-12-10

To determine the temporal and spatial extent of the lactate (Lact) changes as correlated with seizure characteristics and EEG changes in the rat kindling model. Prior studies using MRS have detected cerebral Lact postictally in animal models of seizures and in patients with intractable focal epilepsy. We performed MRS in sham control rats (n = 4) and in rats stimulated in the right hippocampus at two different stages of the kindling and at three time points after the seizures: <2 hours (n = 8 and 5, stage 0 and stage 5), 2 to 3 hours (n = 5 and 6), and >3 hours (n = 4 and 2). Lact/creatine (Cr) and N-acetylaspartate (NAA)/Cr ratios were measured in six contiguous voxels (three left, three right) covering the hippocampi, anterior and posterior regions, and compared with EEG and ictal behavior. Lact/Cr ratios were measured at a very low level in the sham control rats and in the >3-hour group. In the <2-hour group, Lact/Cr increase was higher in stage-5 rats as compared with stage-0 rats (p = 0.001, unpaired t-test) and sham control rats when all the voxels were considered. Lact/Cr ratios were higher in the stimulated area as compared with all other brain areas in stage-0 rats (p = 0.05, paired t-test) but not in the stage-5 rats. Similar results with more inter-animal variability were measured in the 2- to 3-hour group. NAA/Cr ratios increased significantly after stage-0 kindling in the stimulated hippocampus but not after stage-5 kindling. Postictal Lact increase as assayed by MRS correlates with EEG and behavioral seizures and suggests that it would be an additional noninvasive technique for seizure localization during the presurgical evaluation of patients with intractable focal epilepsy.

Linear magnetic spring and spring/motor combination

NASA Technical Reports Server (NTRS)

Patt, Paul J. (Inventor); Stolfi, Fred R. (Inventor)

1991-01-01

A magnetic spring, or a spring and motor combination, providing a linear spring force characteristic in each direction from a neutral position, in which the spring action may occur for any desired coordinate of a typical orthogonal coordinate system. A set of magnets are disposed, preferably symmetrically about a coordinate axis, poled orthogonally to the desired force direction. A second set of magnets, respectively poled opposite the first set, are arranged on the sprung article. The magnets of one of the sets are spaced a greater distance apart than those of the other, such that an end magnet from each set forms a pair having preferably planar faces parallel to the direction of spring force, the faces being offset so that in a neutral position the outer edge of the closer spaced magnet set is aligned with the inner edge of the greater spaced magnet set. For use as a motor, a coil can be arranged with conductors orthogonal to both the magnet pole directions and the direction of desired spring force, located across from the magnets of one set and fixed with respect to the magnets of the other set. In a cylindrical coordinate system having axial spring force, the magnets are radially poled and motor coils are concentric with the cylinder axis.

MRS3D: 3D Spherical Wavelet Transform on the Sphere

NASA Astrophysics Data System (ADS)

Lanusse, F.; Rassat, A.; Starck, J.-L.

2011-12-01

Future cosmological surveys will provide 3D large scale structure maps with large sky coverage, for which a 3D Spherical Fourier-Bessel (SFB) analysis is natural. Wavelets are particularly well-suited to the analysis and denoising of cosmological data, but a spherical 3D isotropic wavelet transform does not currently exist to analyse spherical 3D data. We present a new fast Discrete Spherical Fourier-Bessel Transform (DSFBT) based on both a discrete Bessel Transform and the HEALPIX angular pixelisation scheme. We tested the 3D wavelet transform and as a toy-application, applied a denoising algorithm in wavelet space to the Virgo large box cosmological simulations and found we can successfully remove noise without much loss to the large scale structure. The new spherical 3D isotropic wavelet transform, called MRS3D, is ideally suited to analysing and denoising future 3D spherical cosmological surveys; it uses a novel discrete spherical Fourier-Bessel Transform. MRS3D is based on two packages, IDL and Healpix and can be used only if these two packages have been installed.

PREFACE: MRS International Materials Research Conference (IMRC-2008)

NASA Astrophysics Data System (ADS)

Wang, Zhanguo; Qiu, Yong; Li, Yongxiang

2009-03-01

This volume contains selected papers presented at the MRS International Materials Research Conference (IMRC-2008) held in Chongqing, China, 9-12 June 2008. IMRC-2008 included 9 symposia of A. Eco/Environmental Materials, B. Sustainable Energy Materials, C. Electronic Packaging Materials, D. Electronic Materials, E. Materials and Processes for Flat-panel Displays, F. Functional Ceramics, G. Transportation Materials, H. Magnesium and I. Biomaterials for Medical Applications. Nearly 1200 participants from 33 countries attended the conference, and the conference organizers received more than 700 papers. After the peer review processes, 555 papers were selected to be published in 9 Journals or proceedings, including J. of Materials Research (JMR), Rare Metal Materials and Engineering, J. of Univ. Science and Technology Beijing, Biomedical Materials: Materials for Tissue Engineering and Regenerative Medicine, Chinese Journal of Aeronautics, Materials Science Forum, and Journal of Physics: Conference Series. Among the 555 selected papers, 91 papers are published in this volume, and the topics mainly cover electronic matrials, processes for flat-panel displays and functional ceramics. The editors would like to give special thanks to the graduate students Liwu Jiang, Ming Li and Di He from Beihang University for their hard work compiling and typesetting each paper in this volume. Zhanguo Wang, Yong Qiu and Yongxiang Li Editors

Spring operated accelerator and constant force spring mechanism therefor

NASA Technical Reports Server (NTRS)

Shillinger, G. L., Jr. (Inventor)

1977-01-01

A spring assembly consisting of an elongate piece of flat spring material formed into a spiral configuration and a free running spool in circumscribing relation to which this spring is disposed was developed. The spring has a distal end that is externally accessible so that when the distal end is drawn along a path, the spring unwinds against a restoring force present in the portion of the spring that resides in a transition region between a relatively straight condition on the path and a fully wound condition on the spool. When the distal end is released, the distal end is accelerated toward the spool by the force existing at the transition region which force is proportional to the cross-sectional area of the spring.

Brain MRS glutamine as a biomarker to guide therapy of hyperammonemic coma.

PubMed

O'Donnell-Luria, Anne H; Lin, Alexander P; Merugumala, Sai K; Rohr, Frances; Waisbren, Susan E; Lynch, Rebecca; Tchekmedyian, Vatche; Goldberg, Aaron D; Bellinger, Andrew; McFaline-Figueroa, J Ricardo; Simon, Tracey; Gershanik, Esteban F; Levy, Bruce D; Cohen, David E; Samuels, Martin A; Berry, Gerard T; Frank, Natasha Y

2017-05-01

Acute idiopathic hyperammonemia in an adult patient is a life-threatening condition often resulting in a rapid progression to irreversible cerebral edema and death. While ammonia-scavenging therapies lower blood ammonia levels, in comparison, clearance of waste nitrogen from the brain may be delayed. Therefore, we used magnetic resonance spectroscopy (MRS) to monitor cerebral glutamine levels, the major reservoir of ammonia, in a gastric bypass patient with hyperammonemic coma undergoing therapy with N-carbamoyl glutamate and the ammonia-scavenging agents, sodium phenylacetate and sodium benzoate. Improvement in mental status mirrored brain glutamine levels, as coma persisted for 48h after plasma ammonia normalized. We hypothesize that the slower clearance for brain glutamine levels accounts for the delay in improvement following initiation of treatment in cases of chronic hyperammonemia. We propose MRS to monitor brain glutamine as a noninvasive approach to be utilized for diagnostic and therapeutic monitoring purposes in adult patients presenting with idiopathic hyperammonemia. Copyright © 2017 Elsevier Inc. All rights reserved.

A Preliminary Investigation of Caffeinated Alcohol Use During Spring Break.

PubMed

Linden-Carmichael, Ashley N; Lau-Barraco, Cathy

2016-06-06

Caffeinated alcoholic beverages (e.g., Red Bull and vodka) are popular but associated with negative consequences. CABs may be particularly popular during Spring Break, a potentially risky social event. We aimed to identify the prevalence of Spring Break caffeinated alcohol use, determine how caffeinated alcohol use Spring Break drinking habits differ from usual, and examine the association between Spring Break caffeinated alcohol use and alcohol-related problems. Data were collected from 95 college students during March of 2013 and 2014. Students completed questionnaires of their alcohol and caffeinated alcohol use before and during Spring Break and Spring Break alcohol-related problems. Approximately 54% of students used caffeinated alcohol during Spring Break. Spring Break caffeinated alcohol use was associated with more alcohol-related problems, even after controlling for other alcohol consumed and Spring Break vacation status. Caffeinated alcoholic beverages are commonly consumed during Spring Break and their use uniquely predicted harms. Prevention efforts placed on caffeinated alcoholic beverage users may be helpful in reducing Spring Break-related harms.

Literary aesthetics: beauty, the brain, and Mrs. Dalloway.

PubMed

Hogan, Patrick Colm

2013-01-01

Empirical research indicates that beauty is in part a matter of prototype approximation. Some research suggests that unanticipated pattern recognition is important as well. This essay begins by briefly outlining an account of beauty based on these factors. It goes on to consider complications. Minor complications include the partial incompatibility of these accounts and the importance of differentiating judgments of beauty from aesthetic response. More serious issues include the relative neglect of literature in neurologically-based discussions of beauty, which tend to focus on music or visual art. There is also a relative neglect of emotion, beyond the reward system. Finally, there is the almost complete absence of the sublime. After considering these problems broadly, the essay turns to Virginia Woolf's Mrs. Dalloway, examining its treatment of beauty and sublimity. The aim of this section is not merely to illuminate Woolf's novel by reference to neuroscientific research. It is equally, perhaps more fully, to expand our neuroscientifically grounded account of aesthetic response by drawing on Woolf's novel. In Mrs. Dalloway, there are gestures toward prototypes and patterns in beauty. But the key features are clearly emotional. Specifically, the emotions at issue in feelings of beauty and sublimity appear to be primarily attachment, on the one hand, and a profound sense of isolation, on the other. Woolf's novel also points us toward other features of aesthetic experience, crucially including the emotion-sharing that is a key function of the production and circulation of art. © 2013 Elsevier B.V. All rights reserved.

Development and Deployment of the OpenMRS-Ebola Electronic Health Record System for an Ebola Treatment Center in Sierra Leone

PubMed Central

Jazayeri, Darius; Teich, Jonathan M; Ball, Ellen; Nankubuge, Patricia Alexandra; Rwebembera, Job; Wing, Kevin; Sesay, Alieu Amara; Kanter, Andrew S; Ramos, Glauber D; Walton, David; Cummings, Rachael; Checchi, Francesco; Fraser, Hamish S

2017-01-01

Background Stringent infection control requirements at Ebola treatment centers (ETCs), which are specialized facilities for isolating and treating Ebola patients, create substantial challenges for recording and reviewing patient information. During the 2014-2016 West African Ebola epidemic, paper-based data collection systems at ETCs compromised the quality, quantity, and confidentiality of patient data. Electronic health record (EHR) systems have the potential to address such problems, with benefits for patient care, surveillance, and research. However, no suitable software was available for deployment when large-scale ETCs opened as the epidemic escalated in 2014. Objective We present our work on rapidly developing and deploying OpenMRS-Ebola, an EHR system for the Kerry Town ETC in Sierra Leone. We describe our experience, lessons learned, and recommendations for future health emergencies. Methods We used the OpenMRS platform and Agile software development approaches to build OpenMRS-Ebola. Key features of our work included daily communications between the development team and ground-based operations team, iterative processes, and phased development and implementation. We made design decisions based on the restrictions of the ETC environment and regular user feedback. To evaluate the system, we conducted predeployment user questionnaires and compared the EHR records with duplicate paper records. Results We successfully built OpenMRS-Ebola, a modular stand-alone EHR system with a tablet-based application for infectious patient wards and a desktop-based application for noninfectious areas. OpenMRS-Ebola supports patient tracking (registration, bed allocation, and discharge); recording of vital signs and symptoms; medication and intravenous fluid ordering and monitoring; laboratory results; clinician notes; and data export. It displays relevant patient information to clinicians in infectious and noninfectious zones. We implemented phase 1 (patient tracking; drug

(13)C MRS of human brain at 7 Tesla using [2-(13)C]glucose infusion and low power broadband stochastic proton decoupling.

PubMed

Li, Shizhe; An, Li; Yu, Shao; Ferraris Araneta, Maria; Johnson, Christopher S; Wang, Shumin; Shen, Jun

2016-03-01

Carbon-13 ((13)C) MR spectroscopy (MRS) of the human brain at 7 Tesla (T) may pose patient safety issues due to high radiofrequency (RF) power deposition for proton decoupling. The purpose of present work is to study the feasibility of in vivo (13)C MRS of human brain at 7 T using broadband low RF power proton decoupling. Carboxylic/amide (13)C MRS of human brain by broadband stochastic proton decoupling was demonstrated on a 7 T scanner. RF safety was evaluated using the finite-difference time-domain method. (13)C signal enhancement by nuclear Overhauser effect (NOE) and proton decoupling was evaluated in both phantoms and in vivo. At 7 T, the peak amplitude of carboxylic/amide (13)C signals was increased by a factor of greater than 4 due to the combined effects of NOE and proton decoupling. The 7 T (13)C MRS technique used decoupling power and average transmit power of less than 35 watts (W) and 3.6 W, respectively. In vivo (13)C MRS studies of human brain can be performed at 7 T, well below the RF safety threshold, by detecting carboxylic/amide carbons with broadband stochastic proton decoupling. © 2015 Wiley Periodicals, Inc.

Minutes: Annual Meeting of the President's Committee on Employment of the Handicapped (Washington, D.C., May 1-2, 1969).

ERIC Educational Resources Information Center

President's Committee on Employment of the Handicapped, Washington, DC.

Reporting the events of the meeting of the President's Committee on Employment of the Handicapped, the text includes speeches by Chairman Russell, Senator Bob Dole, Secretary of Labor Schultz, Rene Carpenter, Mr. Lustenberger of the W.T. Grant Company, W.F. Schnitzler of the AFL-CIO, Mrs. Koontz of the Department of Labor, Dr. Harlem, President of…

78 FR 66354 - Warm Springs Irrigation District; Notice of Technical Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-05

... Project No. 13570 b. Date and Time of Meeting: November 14, 2013; 11:00 a.m. Pacific Time (2:00 p.m. Eastern Time). c. Place: Telephone conference call. d. FERC Contact: Kelly Wolcott, [email protected] project. f. Proposed Agenda: 1. Introduction 2. Meeting objectives 3. Plant survey discussion 4. NEPA...

1988 Hanford riverbank springs characterization report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dirkes, R.L.

1990-12-01

This reports presents the results of a special study undertaken to characterize the riverbank springs (i.e., ground-water seepage) entering the Columbia River along the Hanford Site. Radiological and nonradiological analyses were performed. River water samples were also analyzed from upstream and downstream of the Site as well as from the immediate vicinity of the springs. In addition, irrigation return water and spring water entering the river along the shoreline opposite Hanford were analyzed. Hanford-origin contaminants were detected in spring water entering the Columbia River along the Hanford Site. The type and concentrations of contaminants in the spring water were similarmore » to those known to exist in the ground water near the river. The location and extent of the contaminated discharges compared favorably with recent ground-water reports and predictions. Spring discharge volumes remain very small relative to the flow of the Columbia. Downstream river sampling demonstrates the impact of ground-water discharges to be minimal, and negligible in most cases. Radionuclide concentrations were below US Department of Energy Derived Concentration Guides (DCGs) with the exception {sup 90}Sr near the 100-N Area. Tritium, while below the DCG, was detected at concentrations above the US Environmental Protection Agency drinking water standards in several springs. All other radionuclide concentrations were below drinking water standards. Nonradiological contaminants were generally undetectable in the spring water. River water contaminant concentrations, outside of the immediate discharge zones, were below drinking water standards in all cases. 19 refs., 5 figs., 12 tabs.« less

How does the anthropogenic activity affect the spring discharge?

NASA Astrophysics Data System (ADS)

Hao, Yonghong; Zhang, Juan; Wang, Jiaojiao; Li, Ruifang; Hao, Pengmei; Zhan, Hongbin

2016-09-01

Karst hydrological process has largely been altered by climate change and human activity. In many places throughout the world, human activity (e.g. groundwater pumping and dewatering from mining) has intensified and surpassed climate change, where human activity becomes the primary factor that affects groundwater system. But it is still largely unclear how the human activity affects spring discharge in magnitude and periodicity. This study investigates the effects of anthropogenic activity on spring discharge, using the Xin'an Springs of China as an example. The Xin'an Spring discharge were divided into two time periods: the pre-development period from 1956 to 1971 and the post-development period from 1972 to 2013. We confirm the dividing time (i.e. 1971) of these two periods using the Wilcoxon rank-sum test. Then the wavelet transform and wavelet coherence were used to analyze the karst hydrological processes for the two periods respectively. We analyze the correlations of precipitation and the Xin'an spring discharge with the monsoons including the Indian Summer Monsoon (ISM) and the West North Pacific Monsoon (WNPM) and the climate teleconnections including El Niño Southern Oscillation (ENSO) and Pacific Decadal Oscillation (PDO), respectively. The results indicated that the spring discharge was attenuated about 19.63% under the influence of human activity in the Xin'an Springs basin. However, human activity did not alter the size of the resonance frequencies between the spring discharge and the monsoons. In contrast, it reinforced the periodicities of the monsoons-driven spring discharge. It suggested that human has adapted to the major climate periodicities, and human activity had the same rhyme with the primary climate periodicity. In return, human activity enhances the correlation between the monsoons and the spring discharge.

Applying spatial analysis techniques to assess the suitability of multipurpose uses of spring water in the Jiaosi Hot Spring Region, Taiwan

NASA Astrophysics Data System (ADS)

Jang, Cheng-Shin

2016-04-01

The Jiaosi Hot Spring Region is located in northeastern Taiwan and is rich in geothermal springs. The geothermal development of the Jiaosi Hot Spring Region dates back to the 18th century and currently, the spring water is processed for various uses, including irrigation, aquaculture, swimming, bathing, foot spas, and recreational tourism. Because of the proximity of the Jiaosi Hot Spring Region to the metropolitan area of Taipei City, the hot spring resources in this region attract millions of tourists annually. Recently, the Taiwan government is paying more attention to surveying the spring water temperatures in the Jiaosi Hot Spring Region because of the severe spring water overexploitation, causing a significant decline in spring water temperatures. Furthermore, the temperature of spring water is a reliable indicator for exploring the occurrence and evolution of springs and strongly affects hydrochemical reactions, components, and magnitudes. The multipurpose uses of spring water can be dictated by the temperature of the water. Therefore, accurately estimating the temperature distribution of the spring water is critical in the Jiaosi Hot Spring Region to facilitate the sustainable development and management of the multipurpose uses of the hot spring resources. To evaluate the suitability of spring water for these various uses, this study spatially characterized the spring water temperatures of the Jiaosi Hot Spring Region by using ordinary kriging (OK), sequential Gaussian simulation (SGS), and geographical information system (GIS). First, variogram analyses were used to determine the spatial variability of spring water temperatures. Next, OK and SGS were adopted to model the spatial distributions and uncertainty of the spring water temperatures. Finally, the land use (i.e., agriculture, dwelling, public land, and recreation) was determined and combined with the estimated distributions of the spring water temperatures using GIS. A suitable development strategy

1. LOOKING NORTH, SHOWING IODINE SPRING (FOREGROUND), SALT SULPHUR SPRING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. LOOKING NORTH, SHOWING IODINE SPRING (FOREGROUND), SALT SULPHUR SPRING (LEFT BACKGROUND), AND TWIN COTTAGES (UPPER RIGHT) (4 x 5 negative; 5 x 7 print) - Salt Sulpher Springs, U.S. Route 219, Salt Sulphur Springs, Monroe County, WV

Groundwater flow cycling between a submarine spring and an inland fresh water spring.

PubMed

Davis, J Hal; Verdi, Richard

2014-01-01

Spring Creek Springs and Wakulla Springs are large first magnitude springs that derive water from the Upper Floridan Aquifer. The submarine Spring Creek Springs are located in a marine estuary and Wakulla Springs are located 18 km inland. Wakulla Springs has had a consistent increase in flow from the 1930s to the present. This increase is probably due to the rising sea level, which puts additional pressure head on the submarine Spring Creek Springs, reducing its fresh water flow and increasing flows in Wakulla Springs. To improve understanding of the complex relations between these springs, flow and salinity data were collected from June 25, 2007 to June 30, 2010. The flow in Spring Creek Springs was most sensitive to rainfall and salt water intrusion, and the flow in Wakulla Springs was most sensitive to rainfall and the flow in Spring Creek Springs. Flows from the springs were found to be connected, and composed of three repeating phases in a karst spring flow cycle: Phase 1 occurred during low rainfall periods and was characterized by salt water backflow into the Spring Creek Springs caves. The higher density salt water blocked fresh water flow and resulted in a higher equivalent fresh water head in Spring Creek Springs than in Wakulla Springs. The blocked fresh water was diverted to Wakulla Springs, approximately doubling its flow. Phase 2 occurred when heavy rainfall resulted in temporarily high creek flows to nearby sinkholes that purged the salt water from the Spring Creek Springs caves. Phase 3 occurred after streams returned to base flow. The Spring Creek Springs caves retained a lower equivalent fresh water head than Wakulla Springs, causing them to flow large amounts of fresh water while Wakulla Springs flow was reduced by about half. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.

Groundwater flow cycling between a submarine spring and an inland fresh water spring

USGS Publications Warehouse

Davis, J. Hal; Verdi, Richard

2014-01-01

Spring Creek Springs and Wakulla Springs are large first magnitude springs that derive water from the Upper Floridan Aquifer. The submarine Spring Creek Springs are located in a marine estuary and Wakulla Springs are located 18 km inland. Wakulla Springs has had a consistent increase in flow from the 1930s to the present. This increase is probably due to the rising sea level, which puts additional pressure head on the submarine Spring Creek Springs, reducing its fresh water flow and increasing flows in Wakulla Springs. To improve understanding of the complex relations between these springs, flow and salinity data were collected from June 25, 2007 to June 30, 2010. The flow in Spring Creek Springs was most sensitive to rainfall and salt water intrusion, and the flow in Wakulla Springs was most sensitive to rainfall and the flow in Spring Creek Springs. Flows from the springs were found to be connected, and composed of three repeating phases in a karst spring flow cycle: Phase 1 occurred during low rainfall periods and was characterized by salt water backflow into the Spring Creek Springs caves. The higher density salt water blocked fresh water flow and resulted in a higher equivalent fresh water head in Spring Creek Springs than in Wakulla Springs. The blocked fresh water was diverted to Wakulla Springs, approximately doubling its flow. Phase 2 occurred when heavy rainfall resulted in temporarily high creek flows to nearby sinkholes that purged the salt water from the Spring Creek Springs caves. Phase 3 occurred after streams returned to base flow. The Spring Creek Springs caves retained a lower equivalent fresh water head than Wakulla Springs, causing them to flow large amounts of fresh water while Wakulla Springs flow was reduced by about half.

Measurement of Human Skeletal Muscle Oxidative Capacity by 31P-MRS: A Cross-Validation with in vitro measurements

PubMed Central

Lanza, Ian R.; Bhagra, Sumit; Nair, K. Sreekumaran; Port, John D.

2011-01-01

Purpose To cross-validate skeletal muscle oxidative capacity measured by 31P-MRS with in vitro measurements of oxidative capacityin mitochondria isolated from muscle biopsies of the same muscle group in 18 healthy adults. Materials and Methods Oxidative capacity in vivo was determined from PCr recovery kinetics following a 30s maximal isometric knee extension. State 3 respiration was measured in isolated mitochondria using high-resolution respirometry. A second cohort of 10 individuals underwent two 31P-MRS testing sessions to assess the test-retest reproducibility of the method. Results Overall, the in vivo and in vitro methods were well-correlated (r = 0.66 –0.72) and showed good agreement by Bland Altman plots. Excellent reproducibility was observed for the PCr recovery rate constant (CV = 4.6%, ICC = 0.85) and calculated oxidative capacity (CV = 3.4%, ICC = 0.83). Conclusion These results indicate that 31P-MRS corresponds well with gold-standard in vitro measurements and is highly reproducible. PMID:22006551

Geophysical investigation of a freshwater lens on the island of Langeoog, Germany - Insights from combined HEM, TEM and MRS data

NASA Astrophysics Data System (ADS)

Costabel, Stephan; Siemon, Bernhard; Houben, Georg; Günther, Thomas

2017-01-01

A multi-method geophysical survey, including helicopter-borne electromagnetics (HEM), transient electromagnetics (TEM), and magnetic resonance sounding (MRS), was conducted to investigate a freshwater lens on the North Sea island of Langeoog, Germany. The HEM survey covers the entire island and gives an overview of the extent of three freshwater lenses that reach depths of up to 45 m. Ground-based TEM and MRS were conducted particularly on the managed western lens to verify the HEM results and to complement the lithological information from existing boreholes. The results of HEM and TEM are in good agreement. Salt- and freshwater-bearing sediments can, as expected, clearly be distinguished due to their individual resistivity ranges. In the resistivity data, a large transition zone between fresh- and saltwater with a thickness of up to 20 m is identified, the existence of which is verified by borehole logging and sampling. Regarding lithological characterisation of the subsurface, the MRS method provides more accurate and reliable results than HEM and TEM. Using a lithological index derived from MRS water content and relaxation time, thin aquitard structures as well as fine and coarse sand aquifers can be distinguished. Complementing the existing borehole data with the lithology information estimated from MRS, we generate a map showing the occurrence of aquitard structures, which significantly improves the hydrogeological model of the island. Moreover, we demonstrate that the estimates of groundwater conductivity in the sand aquifers from geophysical data are in agreement with the fluid conductivity measured in the boreholes.

Council Meeting Highlights

NASA Astrophysics Data System (ADS)

Council held a very productive meeting on 17 June using telephone conferencing and a Web-based system for sharing documents. Although the Executive Committee and many other committees have long conducted their business telephonically, this was a first for Council. The early date of the Joint Assembly in Nice, which incorporated AGU's 2003 Spring Meeting, meant that the critical item for Council, approval of the slate of candidates for the next election, would not be ready for action at that time. Thus, the meeting was scheduled for June in conjunction with the Planning Committee. The slate of nominees for the 2004-2006 term was approved as presented by the Union and Section nominating committees. The accompanying story provides the names and the process for petition nominations from the membership.

European Materials Research Society Spring Meeting, E-MRS 󈨦 Scientific/Technical Symposia and Exhibition, Held in Congress Center - Palais de la Musique et des Congres - Strasbourg, France on June 16-19, 1998.

DTIC Science & Technology

1998-06-01

MICROPROCES- SING, H.-J. Kahlert and B. Burghardt, MicroLas Lasersystem GmbH, Robert- Bosch - Breite 10, 37079 Göttingen, Germany G-V2 14-30-14:45...Inst.f Phys. Chem., Univ. Göttingen, Tammannstr. 6, 37077 Göttingen, Germany, * present address: MicroLas Lasersystem GmbH, Robert- Bosch -Breite 10...SYNTHESIS OF CN-BCN LAYERS ON DIAMOND FILMS IN BORAZINE AND AMMONIA , M. Ugarov, V. Ageev. A. Karabutov, E. Loubnin, S. Pimenov, V. Konov, Natural

Spring Tire

NASA Technical Reports Server (NTRS)

Asnani, Vivake M.; Benzing, Jim; Kish, Jim C.

2011-01-01

The spring tire is made from helical springs, requires no air or rubber, and consumes nearly zero energy. The tire design provides greater traction in sandy and/or rocky soil, can operate in microgravity and under harsh conditions (vastly varying temperatures), and is non-pneumatic. Like any tire, the spring tire is approximately a toroidal-shaped object intended to be mounted on a transportation wheel. Its basic function is also similar to a traditional tire, in that the spring tire contours to the surface on which it is driven to facilitate traction, and to reduce the transmission of vibration to the vehicle. The essential difference between other tires and the spring tire is the use of helical springs to support and/or distribute load. They are coiled wires that deform elastically under load with little energy loss.

Investigation of NAA and NAAG dynamics underlying visual stimulation using MEGA-PRESS in a functional MRS experiment

PubMed Central

Landim, Ricardo C.G.; Edden, Richard A.E.; Foerster, Bernd; Li, Li Min; Covolan, Roberto J.M.; Castellano, Gabriela

2017-01-01

N-acetyl-aspartate (NAA) is responsible for the majority of the most prominent peak in 1H-MR spectra, and has been used as diagnostic marker for several pathologies. However, ~10% of this peak can be attributed to N-acetyl-aspartyl-glutamate (NAAG), a neuropeptide whose release may be triggered by intense neuronal activation. Separate measurement of NAA and NAAG using MRS is difficult due to large superposition of their spectra. Specifically, in functional MRS (fMRS) experiments, most work has evaluated the sum NAA + NAAG, which does not appear to change during experiments. The aim of this work was to design and perform an fMRS experiment using visual stimulation and a spectral editing sequence, MEGA-PRESS, to further evaluate the individual dynamics of NAA and NAAG during brain activation. The functional paradigm used consisted of three blocks, starting with a rest (baseline) block of 320 s, followed by a stimulus block (640 s) and a rest block (640 s). Twenty healthy subjects participated in this study. On average, subjects followed a pattern of NAA decrease and NAAG increase during stimulation, with a tendency to return to basal levels at the end of the paradigm, with a peak NAA decrease of −(21 ± 19)% and a peak NAAG increase of (64 ± 62)% (Wilcoxon test, p < 0.05). These results may relate to: 1) the only known NAAG synthesis pathway is from NAA and glutamate; 2) a relationship between NAAG and the BOLD response. PMID:26656908

Investigation of NAA and NAAG dynamics underlying visual stimulation using MEGA-PRESS in a functional MRS experiment.

PubMed

Landim, Ricardo C G; Edden, Richard A E; Foerster, Bernd; Li, Li Min; Covolan, Roberto J M; Castellano, Gabriela

2016-04-01

N-acetyl-aspartate (NAA) is responsible for the majority of the most prominent peak in (1)H-MR spectra, and has been used as diagnostic marker for several pathologies. However, ~10% of this peak can be attributed to N-acetyl-aspartyl-glutamate (NAAG), a neuropeptide whose release may be triggered by intense neuronal activation. Separate measurement of NAA and NAAG using MRS is difficult due to large superposition of their spectra. Specifically, in functional MRS (fMRS) experiments, most work has evaluated the sum NAA+NAAG, which does not appear to change during experiments. The aim of this work was to design and perform an fMRS experiment using visual stimulation and a spectral editing sequence, MEGA-PRESS, to further evaluate the individual dynamics of NAA and NAAG during brain activation. The functional paradigm used consisted of three blocks, starting with a rest (baseline) block of 320 s, followed by a stimulus block (640 s) and a rest block (640 s). Twenty healthy subjects participated in this study. On average, subjects followed a pattern of NAA decrease and NAAG increase during stimulation, with a tendency to return to basal levels at the end of the paradigm, with a peak NAA decrease of -(21±19)% and a peak NAAG increase of (64±62)% (Wilcoxon test, p<0.05). These results may relate to: 1) the only known NAAG synthesis pathway is from NAA and glutamate; 2) a relationship between NAAG and the BOLD response. Copyright © 2015 Elsevier Inc. All rights reserved.

PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS.

PubMed

Almeida, Gilberto S; Bawn, Carlo M; Galler, Martin; Wilson, Ian; Thomas, Huw D; Kyle, Suzanne; Curtin, Nicola J; Newell, David R; Maxwell, Ross J

2017-09-01

Poly(adenosine diphosphate ribose) polymerases (PARPs) are multifunctional proteins which play a role in many cellular processes. Namely, PARP1 and PARP2 have been shown to be involved in DNA repair, and therefore are valid targets in cancer treatment with PARP inhibitors, such as rucaparib, currently in clinical trials. Proton magnetic resonance spectroscopy ( 1 H-MRS) was used to study the impact of rucaparib in vitro and ex vivo in liver tissue from mice, via quantitative analysis of nicotinamide adenosine diphosphate (NAD + ) spectra, to assess the potential of MRS as a biomarker of the PARP inhibitor response. SW620 (colorectal) and A2780 (ovarian) cancer cell lines, and PARP1 wild-type (WT) and PARP1 knock-out (KO) mice, were treated with rucaparib, temozolomide (methylating agent) or a combination of both drugs. 1 H-MRS spectra were obtained from perchloric acid extracts of tumour cells and mouse liver. Both cell lines showed an increase in NAD + levels following PARP inhibitor treatment in comparison with temozolomide treatment. Liver extracts from PARP1 WT mice showed a significant increase in NAD + levels after rucaparib treatment compared with untreated mouse liver, and a significant decrease in NAD + levels in the temozolomide-treated group. The combination of rucaparib and temozolomide did not prevent the NAD + depletion caused by temozolomide treatment. The 1 H-MRS results show that NAD + levels can be used as a biomarker of PARP inhibitor and methylating agent treatments, and suggest that in vivo measurement of NAD + would be valuable. Copyright © 2017 John Wiley & Sons, Ltd.

Development and Deployment of the OpenMRS-Ebola Electronic Health Record System for an Ebola Treatment Center in Sierra Leone.

PubMed

Oza, Shefali; Jazayeri, Darius; Teich, Jonathan M; Ball, Ellen; Nankubuge, Patricia Alexandra; Rwebembera, Job; Wing, Kevin; Sesay, Alieu Amara; Kanter, Andrew S; Ramos, Glauber D; Walton, David; Cummings, Rachael; Checchi, Francesco; Fraser, Hamish S

2017-08-21

Stringent infection control requirements at Ebola treatment centers (ETCs), which are specialized facilities for isolating and treating Ebola patients, create substantial challenges for recording and reviewing patient information. During the 2014-2016 West African Ebola epidemic, paper-based data collection systems at ETCs compromised the quality, quantity, and confidentiality of patient data. Electronic health record (EHR) systems have the potential to address such problems, with benefits for patient care, surveillance, and research. However, no suitable software was available for deployment when large-scale ETCs opened as the epidemic escalated in 2014. We present our work on rapidly developing and deploying OpenMRS-Ebola, an EHR system for the Kerry Town ETC in Sierra Leone. We describe our experience, lessons learned, and recommendations for future health emergencies. We used the OpenMRS platform and Agile software development approaches to build OpenMRS-Ebola. Key features of our work included daily communications between the development team and ground-based operations team, iterative processes, and phased development and implementation. We made design decisions based on the restrictions of the ETC environment and regular user feedback. To evaluate the system, we conducted predeployment user questionnaires and compared the EHR records with duplicate paper records. We successfully built OpenMRS-Ebola, a modular stand-alone EHR system with a tablet-based application for infectious patient wards and a desktop-based application for noninfectious areas. OpenMRS-Ebola supports patient tracking (registration, bed allocation, and discharge); recording of vital signs and symptoms; medication and intravenous fluid ordering and monitoring; laboratory results; clinician notes; and data export. It displays relevant patient information to clinicians in infectious and noninfectious zones. We implemented phase 1 (patient tracking; drug ordering and monitoring) after 2

Studying Springs in Series Using a Single Spring

ERIC Educational Resources Information Center

Serna, Juan D.; Joshi, Amitabh

2011-01-01

Springs are used for a wide range of applications in physics and engineering. Possibly, one of their most common uses is to study the nature of restoring forces in oscillatory systems. While experiments that verify Hooke's law using springs are abundant in the physics literature, those that explore the combination of several springs together are…

Parsimonious Hydrologic and Nitrate Response Models For Silver Springs, Florida

NASA Astrophysics Data System (ADS)

Klammler, Harald; Yaquian-Luna, Jose Antonio; Jawitz, James W.; Annable, Michael D.; Hatfield, Kirk

2014-05-01

Silver Springs with an approximate discharge of 25 m3/sec is one of Florida's first magnitude springs and among the largest springs worldwide. Its 2500-km2 springshed overlies the mostly unconfined Upper Floridan Aquifer. The aquifer is approximately 100 m thick and predominantly consists of porous, fractured and cavernous limestone, which leads to excellent surface drainage properties (no major stream network other than Silver Springs run) and complex groundwater flow patterns through both rock matrix and fast conduits. Over the past few decades, discharge from Silver Springs has been observed to slowly but continuously decline, while nitrate concentrations in the spring water have enormously increased from a background level of 0.05 mg/l to over 1 mg/l. In combination with concurrent increases in algae growth and turbidity, for example, and despite an otherwise relatively stable water quality, this has given rise to concerns about the ecological equilibrium in and near the spring run as well as possible impacts on tourism. The purpose of the present work is to elaborate parsimonious lumped parameter models that may be used by resource managers for evaluating the springshed's hydrologic and nitrate transport responses. Instead of attempting to explicitly consider the complex hydrogeologic features of the aquifer in a typically numerical and / or stochastic approach, we use a transfer function approach wherein input signals (i.e., time series of groundwater recharge and nitrate loading) are transformed into output signals (i.e., time series of spring discharge and spring nitrate concentrations) by some linear and time-invariant law. The dynamic response types and parameters are inferred from comparing input and output time series in frequency domain (e.g., after Fourier transformation). Results are converted into impulse (or step) response functions, which describe at what time and to what magnitude a unitary change in input manifests at the output. For the

Deprescribing for frail older people - Learning from the case of Mrs. Hansen.

PubMed

Granas, Anne Gerd; Stendal Bakken, Marit; Ruths, Sabine; Taxis, Katja

2017-07-13

Drug treatment is often an essential part in treatment and prevention of diseases in older people, but there is much concern about inappropriate medication use. This paper aims to describe the complexity of medication safety issues and clinical judgments when optimizing prescribing in older individuals. It uses the case of Mrs. Hansen, an aged nursing home resident, to illustrate the facilitators and barriers of this process. With decreasing life expectancy, medication use should shift from cure to care, focusing on symptomatic treatment to increase the patient's well-being. In Mrs. Hansen's case, the number of (potentially) dangerous medications were reduced, and non-pharmacological alternatives were considered. There were some medicines added, as underprescribing can also be a problem in older people. Deprescribing long-standing treatment can be interpreted by the patient and family as "giving up hope". More clinical evidence and practical communication tools are needed to guide deprescribing decisions, taking medical and patient-centered priorities into account. Studies evaluating such interventions should select outcome measures that are particularly relevant for frail old individuals. Copyright © 2017. Published by Elsevier Inc.

A Low Frequency FBG Accelerometer with Symmetrical Bended Spring Plates.

PubMed

Liu, Fufei; Dai, Yutang; Karanja, Joseph Muna; Yang, Minghong

2017-01-22

To meet the requirements for low-frequency vibration monitoring, a new type of FBG (fiber Bragg grating) accelerometer with a bended spring plate is proposed. Two symmetrical bended spring plates are used as elastic elements, which drive the FBG to produce axial strains equal in magnitude but opposite in direction when exciting vibrations exist, leading to doubling the wavelength shift of the FBG. The mechanics model and a numerical method are presented in this paper, with which the influence of the structural parameters on the sensitivity and the eigenfrequency are discussed. The test results show that the sensitivity of the accelerometer is more than 1000 pm/g when the frequency is within the 0.7-20 Hz range.

Joint Force Quarterly. Number 7, Spring 1995

DTIC Science & Technology

1995-02-01

Rangers boarding Thai helicopter during Cobra Gold ’94. U .S . A rm y (B ria n G av in ) 0507 Macke 3/3/04 1:50 PM Page 14 Spring 1995...L D W A T E R - N I C H O L S Rangers aboard USS George Washington. U .S . N av y (S te ve M ill er ) 1307 Adolph 3/3/04 2:59 PM Page 50 Spring... Galaxy . C om b at C am er a Im ag er y (M ar vi n K ra us e) Combat Camera Imagery (Chris U. Putnam) M–113A2 rolling onto ramp at Entebbe,

'Incongruous juxtapositions': the chimaera and Mrs McK.

PubMed

Martin, Aryn

2007-09-01

A century ago, the German botanist Hans Winkler (best known for coining the term 'genome') accomplished two novel transplantations. First, he produced a single plant that grafted together two completely disparate species: tomato and nightshade. Second, he chose the descriptive word 'chimaera' to name his innovation, transplanting the term from mythology to biology. This paper features Mrs McK, the first human chimera, and thus follows the term from botany to clinical medicine. Her remarkable story, pieced together from the notes, drafts and correspondence of Robert Race and his colleagues at the MRC Blood Group Unit, draws attention to the significance of names and naming.

Dynamic nuclear polarization and optimal control spatial-selective 13C MRI and MRS

NASA Astrophysics Data System (ADS)

Vinding, Mads S.; Laustsen, Christoffer; Maximov, Ivan I.; Søgaard, Lise Vejby; Ardenkjær-Larsen, Jan H.; Nielsen, Niels Chr.

2013-02-01

Aimed at 13C metabolic magnetic resonance imaging (MRI) and spectroscopy (MRS) applications, we demonstrate that dynamic nuclear polarization (DNP) may be combined with optimal control 2D spatial selection to simultaneously obtain high sensitivity and well-defined spatial restriction. This is achieved through the development of spatial-selective single-shot spiral-readout MRI and MRS experiments combined with dynamic nuclear polarization hyperpolarized [1-13C]pyruvate on a 4.7 T pre-clinical MR scanner. The method stands out from related techniques by facilitating anatomic shaped region-of-interest (ROI) single metabolite signals available for higher image resolution or single-peak spectra. The 2D spatial-selective rf pulses were designed using a novel Krotov-based optimal control approach capable of iteratively fast providing successful pulse sequences in the absence of qualified initial guesses. The technique may be important for early detection of abnormal metabolism, monitoring disease progression, and drug research.

Springs of Florida

USGS Publications Warehouse

Rosenau, Jack C.; Faulkner, Glen L.; Hendry, Charles W.; Hull, Robert W.

1977-01-01

The first comprehensive report of Florida's springs, which contains both a story of the springs and a collection of facts about them, was published thirty years ago (Ferguson and others, 1947). Since then, much additional data on springs have been gathered and the current report, Springs of Florida, makes a wealth of information on springs available to the public. Springs of Florida, prepared by the U.S. Geological Survey in cooperation with the Bureau of Geology, Florida Department of Natural Resources, publishers, and the Bureau of Water Resources Management, Florida Department of Environmental Regulation, is intended to provide sufficient background information for a lucid understanding of the nature and occurrence of the springs in the State.

Reduced Brain GABA in Primary Insomnia: Preliminary Data from 4T Proton Magnetic Resonance Spectroscopy (1H-MRS)

PubMed Central

Winkelman, John W.; Buxton, Orfeu M.; Jensen, J. Eric; Benson, Kathleen L.; O'Connor, Shawn P.; Wang, Wei; Renshaw, Perry F.

2008-01-01

Study Objectives: Both basic and clinical data suggest a potential significant role for GABA in the etiology and maintenance of primary insomnia (PI). Proton magnetic resonance spectroscopy (1H-MRS) can non-invasively determine GABA levels in human brain. Our objective was to assess GABA levels in unmedicated individuals with PI, using 1H-MRS. Design and Setting: Matched-groups, cross-sectional study conducted at two university-based hospitals. Participants: Sixteen non-medicated individuals (8 women) with PI (mean age = 37.3 +/− 8.1) and 16 (7 women) well-screened normal sleepers (mean age = 37.6 +/− 4.5). Methods and Measurements: PI was established with an unstructured clinical interview, a Structured Clinical Interview for DSM-IV (SCID), sleep diary, actigraphy and polysomnography (PSG). 1H-MRS data were collected on a Varian 4 Tesla magnetic resonance imaging/spectroscopy scanner. Global brain GABA levels were averaged from samples in the basal ganglia, thalamus, and temporal, parietal, and occipital white-matter and cortex. Results: Average brain GABA levels were nearly 30% lower in patients with PI (.18 +/− .06) compared to controls (.25 +/− .11). GABA levels were negatively correlated with wake after sleep onset (WASO) on two independent PSGs (r = −0.71, p = 0.0024 and −0.70, p = 0.0048). Conclusions: Our preliminary finding of a global reduction in GABA in non-medicated individuals with PI is the first demonstration of a neurochemical difference in the brains of those with PI compared to normal sleeping controls. 1H-MRS is a valuable tool to assess GABA in vivo, and may provide a means to shed further light on the neurobiology of insomnia. Citation: Winkelman JW; Buxton OM; Jensen JE; Benson KL; O'Connor SP; Wang W; Renshaw PF. Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS). SLEEP 2008;31(11):1499–1506. PMID:19014069

R&W Club Frederick Readies for Spring and Beyond | Poster

Cancer.gov

By Carolynne Keenan, Guest Writer What do discounted Frederick Keys tickets, a wine tour of Frederick area vineyards, a Segway tour of Washington, DC, a summertime National Parks tour, and a special children’s Easter party have in common? All are activities that the Recreation & Welfare (R&W) Club Frederick is currently developing for spring 2013. At the first members meeting

Variable stiffness torsion springs

NASA Astrophysics Data System (ADS)

Alhorn, Dean C.; Polites, Michael E.

1994-05-01

In a torsion spring the spring action is a result of the relationships between the torque applied in twisting the spring, the angle through which the torsion spring twists, and the modulus of elasticity of the spring material in shear. Torsion springs employed industrially have been strips, rods, or bars, generally termed shafts, capabable of being flexed by twisting their axes. They rely on the variations in shearing forces to furnish an internal restoring torque. In the torsion springs herein the restoring torque is external and therefore independent of the shearing modulus of elasticity of the torsion spring shaft. Also provided herein is a variable stiffness torsion spring. This torsion spring can be so adjusted as to have a given spring constant. Such variable stiffness torsion springs are extremely useful in gimballed payloads such as sensors, telescopes, and electronic devices on such platforms as a space shuttle or a space station.

Variable stiffness torsion springs

NASA Technical Reports Server (NTRS)

Alhorn, Dean C. (Inventor); Polites, Michael E. (Inventor)

1995-01-01

In a torsion spring the spring action is a result of the relationships between the torque applied in twisting the spring, the angle through which the torsion spring twists, and the modulus of elasticity of the spring material in shear. Torsion springs employed industrially have been strips, rods, or bars, generally termed shafts, capabable of being flexed by twisting their axes. They rely on the variations in shearing forces to furnish an internal restoring torque. In the torsion springs herein the restoring torque is external and therefore independent of the shearing modulus of elasticity of the torsion spring shaft. Also provided herein is a variable stiffness torsion spring. This torsion spring can be so adjusted as to have a given spring constant. Such variable stiffness torsion springs are extremely useful in gimballed payloads such as sensors, telescopes, and electronic devices on such platforms as a space shuttle or a space station.

Variable stiffness torsion springs

NASA Astrophysics Data System (ADS)

Alhorn, Dean C.; Polites, Michael E.

1995-08-01

In a torsion spring the spring action is a result of the relationships between the torque applied in twisting the spring, the angle through which the torsion spring twists, and the modulus of elasticity of the spring material in shear. Torsion springs employed industrially have been strips, rods, or bars, generally termed shafts, capabable of being flexed by twisting their axes. They rely on the variations in shearing forces to furnish an internal restoring torque. In the torsion springs herein the restoring torque is external and therefore independent of the shearing modulus of elasticity of the torsion spring shaft. Also provided herein is a variable stiffness torsion spring. This torsion spring can be so adjusted as to have a given spring constant. Such variable stiffness torsion springs are extremely useful in gimballed payloads such as sensors, telescopes, and electronic devices on such platforms as a space shuttle or a space station.

Variable stiffness torsion springs

NASA Technical Reports Server (NTRS)

Alhorn, Dean C. (Inventor); Polites, Michael E. (Inventor)

1994-01-01

In a torsion spring the spring action is a result of the relationships between the torque applied in twisting the spring, the angle through which the torsion spring twists, and the modulus of elasticity of the spring material in shear. Torsion springs employed industrially have been strips, rods, or bars, generally termed shafts, capabable of being flexed by twisting their axes. They rely on the variations in shearing forces to furnish an internal restoring torque. In the torsion springs herein the restoring torque is external and therefore independent of the shearing modulus of elasticity of the torsion spring shaft. Also provided herein is a variable stiffness torsion spring. This torsion spring can be so adjusted as to have a given spring constant. Such variable stiffness torsion springs are extremely useful in gimballed payloads such as sensors, telescopes, and electronic devices on such platforms as a space shuttle or a space station.

78 FR 13329 - U.S. Air Force Academy Board of Visitors Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... meeting in Harmon Hall at the United States Air Force Academy in Colorado Springs, Colorado on March 15-16... meeting is to review morale and discipline, social climate, curriculum, instruction, infrastructure...

The false spring of 2012, earliest in North American record

USGS Publications Warehouse

Ault, T.R.; Henebry, G.M.; de Beurs, K. M.; Schwartz, M.D.; Betancourt, Julio L.; Moore, David

2013-01-01

Phenology - the study of recurring plant and animal life cycle stages, especially their timing and relationships with weather and climate - is becoming an essential tool for documenting, communicating, and anticipating the consequences of climate variability and change. For example, March 2012 broke numerous records for warm temperatures and early flowering in the United States [Karl et al., 2012; Elwood et al., 2013]. Many regions experienced a “false spring,” a period of weather in late winter or early spring sufficiently mild and long to bring vegetation out of dormancy prematurely, rendering it vulnerable to late frost and drought.As global climate warms, increasingly warmer springs may combine with the random climatological occurrence of advective freezes, which result from cold air moving from one region to another, to dramatically increase the future risk of false springs, with profound ecological and economic consequences [e.g., Gu et al., 2008; Marino et al., 2011; Augspurger, 2013]. For example, in the false spring of 2012, an event embedded in long-term trends toward earlier spring [e.g., Schwartz et al., 2006], the frost damage to fruit trees totaled half a billion dollars in Michigan alone, prompting the federal government to declare the state a disaster area [Knudson, 2012].

Use of the Titles Ms., Miss or Mrs.: Does It Make a Difference?

ERIC Educational Resources Information Center

Conner, Jane; And Others

1986-01-01

People in a shopping mall were asked to read a paragraph about an achieving woman given the title Miss, Mrs., Ms., or not given a title. Readers of Ms titled paragraph rated her less honest. No effects obtained for other rating dimensions. Results may indicate public acceptance of Ms title. (MCK)

MRI and (1)H-MRS in adenosine kinase deficiency.

PubMed

Staufner, C; Blom, H J; Dionisi-Vici, C; Freisinger, P; Makhseed, N; Ballhausen, D; Kölker, S; Hoffmann, G F; Harting, I

2016-07-01

Adenosine kinase deficiency (ADK deficiency) is a recently described disorder of methionine and adenosine metabolism resulting in a neurological phenotype with developmental delay, muscular hypotonia, and epilepsy as well as variable systemic manifestations. The underlying neuropathology is poorly understood. We have investigated MRI and (1)H-MRS changes in ADK deficiency in order to better understand the in vivo neuropathologic changes of ADK deficiency. Systematic evaluation of 21 MRIs from eight patients (age range 9 days-14.6 years, mean 3.9 years, median 2.7 years) including diffusion-weighted imaging in six and (1)H-MRS in five patients. Brain maturation was delayed in the neonatal period and in infancy (6/6), but ultimately complete. White matter changes occurring in five of eight patients were discrete, periventricular, and unspecific (4/5), or diffuse with sparing of optic radiation, corona radiata, and pyramidal tracts (1/5). Choline was low in white matter spectra (3/3), while there was no indication of low creatine in white matter or basal ganglia (5/5), and diffusion was variably decreased or increased. Central tegmental tract hyperintensity was a common finding (6/8), as was supratentorial atrophy (6/8). MRI changes in ADK deficiency consist of delayed but ultimately completed brain maturation with later onset of mostly unspecific white matter changes and potentially transient central tegmental tract hyperintensity. Immaturity on neonatal MRI is consistent with prenatal onset of disease and reduced choline with lower membrane turnover resulting in delayed myelination and deficient myelin maintenance.

The Coming of Age of LTAs: Proceedings of the Meeting; Council on Library Technology (Fourth Annual, Palm Beach, Florida, June 4-6, 1970).

ERIC Educational Resources Information Center

Rudnik, Mary Chrysantha, Ed.

The actual performance and use of library technical assistants (LTSs) and the question of certification were the topics considered by the sixty participants at this meeting. Evidence of the existence and use of LTAs was given by Mrs. Elnora Portteus in her paper entitled: "The Role of Library Technical Assistants - Actual and Potential," in which…

ITSA Committee meets

NASA Astrophysics Data System (ADS)

The Organizing Committee for the IAHS Third Scientific Assembly (ITSA) met on May 16, 1988, during the AGU Spring Meeting in Baltimore, Md. The Committee was pleased to have three of the IAHS Officers attend the meeting. Secretary General Henny Colenbrander, TNO, The Hague, Netherlands; Treasurer Charles Riggs, U.S. Geological Survey, Reston, Va.; and President Vit Klemes, National Hydrology Research Institute, Saskatoon, Canada, were all present.The work of the committee resulted later in production of the ITSA Second Circular. The complete circular with registration forms was printed in the July 19 issue of Eos, and is also available from Ivan Johnson , Chairman, ITSA Organizing Committee, 7474 Upham Court, Arvada, CO 80003; tel.: 303-425-5610.

Differences in open versus laparoscopic gastric bypass mortality risk using the Obesity Surgery Mortality Risk Score (OS-MRS).

PubMed

Brolin, Robert E; Cody, Ronald P; Marcella, Stephen W

2015-01-01

The Obesity Surgery Mortality Risk Score (OS-MRS) was developed to ascertain preoperative mortality risk of patients having bariatric surgery. To date there has not been a comparison between open and laparoscopic operations using the OS-MRS. To determine whether there are differences in mortality risk between open and laparoscopic Roux-en-Y Gastric Bypass (RYGB) using the OS-MRS. Three university-affiliated hospitals. The 90-day mortality of 2467 consecutive patients who had primary open (1574) or laparoscopic (893) RYGB performed by one surgeon was determined. Univariate and multivariate analysis using 5 OS-MRS risk factors including body mass index (BMI) gender, age>45, presence of hypertension and preoperative deep vein thrombosis (DVT) risk was performed in each group. Each patient was placed in 1 of 3 OS-MRS risk classes based on the number of risks: A (0-1), B (2-3), and C (4-5). Preoperative BMI and DVT risk factors were significantly greater in the open group (OG). Preoperative age was significantly greater in the laparoscopic group (LG). There were significantly more class B and C patients in LG. Ninety-day mortality rates for OG and LG patients were 1.0% and .9%, respectively. Pulmonary embolism was the most common cause of death. All deaths in LG occurred during first 4 years of that experience. Mortality rate by class was A = .1%; B = 1.5%; C = 2.3%. The difference in mortality between class B and C patients was not significant. Univariate analysis in the OG indicated that BMI, age, gender, and DVT risk were significant predictors of mortality. In the LG only BMI and DVT were significant predictors of death. Presence of hypertension was not a significant predictor in either group. Multivariate analysis excluding hypertension found that age was predictive of mortality in the OG while BMI (P = .057) and gender (P = .065) approached statistical significance. Conversely, only BMI was predictive of mortality in the LG with age approaching significance (P

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ono, Luis K.; Park, Nam-Gyu; Zhu, Kai

The Symposium ES1, Perovskite Solar Cells - Towards Commercialization, held at the 2017 Materials Research Society (MRS) Spring Meeting in Phoenix, Arizona (April 17-21, 2017) received ~200 abstracts. The 23 invited talks and 72 contributed oral presentations as well as 3 poster presentation sessions were organized into 13 principal themes according to the contents of the received abstracts. This Energy Focus article provides a concise summary of the opinions from the scientists and engineers who participated in this symposium regarding the recent progresses, challenges, and future directions for perovskite solar cells as well as other optoelectronic devices.

Perovskite Solar Cells—Towards Commercialization

DOE PAGES

Ono, Luis K.; Park, Nam-Gyu; Zhu, Kai; ...

2017-07-13

The Symposium ES1, Perovskite Solar Cells - Towards Commercialization, held at the 2017 Materials Research Society (MRS) Spring Meeting in Phoenix, Arizona (April 17-21, 2017) received ~200 abstracts. The 23 invited talks and 72 contributed oral presentations as well as 3 poster presentation sessions were organized into 13 principal themes according to the contents of the received abstracts. This Energy Focus article provides a concise summary of the opinions from the scientists and engineers who participated in this symposium regarding the recent progresses, challenges, and future directions for perovskite solar cells as well as other optoelectronic devices.

Preliminary examination of spring break alcohol use and related consequences.

PubMed

Lee, Christine M; Lewis, Melissa A; Neighbors, Clayton

2009-12-01

The authors examined the extent to which college student drinkers are at risk for experiencing negative alcohol-related consequences during Spring Break. A sample of first-year college student drinkers (N = 726) participated by completing an online survey assessing typical drinking, as well as Spring Break drinking and related consequences. Findings suggest Spring Break drinking was positively associated with alcohol-related consequences during Spring Break, even after controlling for sex and typical drinking. Furthermore, results indicated that typical drinking moderated the relationship between Spring Break drinking and expected zero-values (i.e., not reporting any Spring Break consequences), such that the association between Spring Break drinking and the likelihood of being a zero-score was less evident for those who are typically lighter drinkers. Identifying and examining temporal and contextually relevant events and associated drinking is critical for understanding and ultimately preventing extreme drinking and associated consequences associated with specific events like Spring Break, which place many students at high risk for experiencing acute harm. Copyright 2009 APA

Metabolic profile of liver damage in non-cirrhotic virus C and autoimmune hepatitis: A proton decoupled 31P-MRS study.

PubMed

Hakkarainen, Antti; Puustinen, Lauri; Kivisaari, Reetta; Boyd, Sonja; Nieminen, Urpo; Arkkila, Perttu; Lundbom, Nina

2017-05-01

To study liver 31 P MRS, histology, transient elastography, and liver function tests in patients with virus C hepatitis (HCV) or autoimmune hepatitis (AIH) to test the hypothesis that 31 P MR metabolic profile of these diseases differ. 25 patients with HCV (n=12) or AIH (n=13) underwent proton decoupled 31 P MRS spectroscopy performed on a 3.0T MR imager. Intensities of phosphomonoesters (PME) of phosphoethanolamine (PE) and phosphocholine (PC), phosphodiesters (PDE) of glycerophosphoethanolamine (GPE) and glycerophosphocholine (GPC), and γ, α and β resonances of adenosine triphosphate (ATP), and nicotinamide adenine dinucleotide phosphate (NADPH) were determined. Liver stiffness was measured by transient elastography. Inflammation and fibrosis were staged according to METAVIR from biopsy samples. Activities of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALT) and thromboplastin time (TT) were determined from serum samples. PME had a stronger correlation with AST (z=1.73, p=0.04) and ALT (z=1.77, p=0.04) in HCV than in AIH patients. PME, PME/PDE, PE/GPE correlated positively and PDE negatively with inflammatory activity. PE, PC and PME correlated positively with liver function tests. 31 P-MRS suggests a more serious liver damage in HCV than in AIH with similar histopathological findings. 31 P-MRS is more sensitive in detecting inflammation than fibrosis in the liver. Copyright © 2017 Elsevier B.V. All rights reserved.

Large springs in the United States

USGS Publications Warehouse

Meinzer, Oscar Edward

1927-01-01

What are the largest springs in the United States, how much water do they discharge, and what geologic conditions produce them are questions of much popular interest and considerable scientific and economic importance. Yet the information in regard to large springs has been so widely scattered and so difficult to interpret that most people have only very vague notions on the subject. The present paper is in a sense a by-product of a more comprehensive investigation of the origin, discharge, and quantity of ground water in the United States. It has, however, required, extensive search for data and critical analysis of the data that were obtained. The task would have been virtually impossible except for the hearty cooperation of the district engineers and other members of the water- resources branch of the Geological Survey, who are really coauthors of this paper. I wish to acknowledge especially the help of Kirk Bryan, G. C. Stevens, W. E. Hall, W. E. King, E. L. Williams, H. C. Beckman, C. E. Ellsworth, C. E. McCashin, C. G. Paulsen, W. G. Hoyt, H. T. Stearns, H. D. McGlashan, R. C. Briggs, F. F. Henshaw, W. A. Lamb, G. M. Hall, E. C. LaRue, and A. B. Purton

Cerebral (1)H MRS alterations in recreational 3, 4-methylenedioxymethamphetamine (MDMA, "ecstasy") users.

PubMed

Chang, L; Ernst, T; Grob, C S; Poland, R E

1999-10-01

3,4-methylenedioxymethamphetamine (MDMA) is an illicit drug that has been associated with serotonergic axonal degeneration in animals. This study evaluates neurochemical abnormalities in recreational MDMA users. Twenty-two MDMA users and 37 normal subjects were evaluated with magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy ((1)H MRS) in the mid-frontal, mid-occipital, and parietal brain regions. (1)H MRS showed normal N-acetyl (NA) compounds in all brain regions. The myo-inositol (MI) concentration (+16.3%, P = 0.04) and the MI to creatine (CR) ratio (+14.1%, P = 0. 01) were increased in the parietal white matter of MDMA users. The cumulative lifetime MDMA dose showed significant effects on [MI] in the parietal white matter and the occipital cortex. The normal NA concentration suggests a lack of significant neuronal injury in recreational MDMA users. However, the usage-related increase in MI suggests that exposure to MDMA, even at recreational doses, may cause increased glial content. J. Magn. Reson. Imaging 1999;10:521-526. Copyright 1999 Wiley-Liss, Inc.

A comparison of liver fat content as determined by magnetic resonance imaging-proton density fat fraction and MRS versus liver histology in non-alcoholic fatty liver disease.

PubMed

Idilman, Ilkay S; Keskin, Onur; Celik, Azim; Savas, Berna; Elhan, Atilla Halil; Idilman, Ramazan; Karcaaltincaba, Musturay

2016-03-01

Many imaging methods have been defined for quantification of hepatic steatosis in non-alcoholic fatty liver disease (NAFLD). However, studies comparing the efficiency of magnetic resonance imaging-proton density fat fraction (MRI-PDFF), magnetic resonance spectroscopy (MRS), and liver histology for quantification of liver fat content are limited. To compare the efficiency of MRI-PDFF and MRS in the quantification of liver fat content in individuals with NAFLD. A total of 19 NAFLD patients underwent MRI-PDFF, MRS, and liver biopsy for quantification of liver fat content. The MR examinations were performed on a 1.5 HDx MRI system. The MRI protocol included T1-independent volumetric multi-echo gradient-echo imaging with T2* correction and spectral fat modeling and MRS with STEAM technique. A close correlation was observed between liver MRI-PDFF- and histology- determined steatosis (r = 0.743, P < 0.001) and between liver MRS- and histology-determined steatosis (r = 0.712, P < 0.001), with no superiority between them (ƶ = 0.19, P = 0.849). For quantification of hepatic steatosis, a high correlation was observed between the two MRI methods (r = 0.986, P < 0.001). MRI-PDFF and MRS accurately differentiated moderate/severe steatosis from mild/no hepatic steatosis (P = 0.007 and 0.013, respectively), with no superiority between them (AUCMRI-PDFF = 0.881 ± 0.0856 versus AUCMRS = 0.857 ± 0.0924, P = 0.461). Both MRI-PDFF and MRS can be used for accurate quantification of hepatic steatosis. © The Foundation Acta Radiologica 2015.

EFFECT OF INTERFERON-α ON CORTICAL GLUTAMATE IN PATIENTS WITH HEPATITIS C: A PROTON MRS STUDY

PubMed Central

Taylor, Matthew J; Godlewska, Beata; Near, Jamie; Christmas, David; Potokar, John; Collier, Jane; Klenerman, Paul; Barnes, Eleanor; Cowen, Philip J

2013-01-01

Background The development of depressive symptomatology is a recognised complication of treatment with the cytokine, interferon-α, and has been seen as supporting inflammatory theories of the pathophysiology of major depression. Major depression has been associated with changes in glutamatergic activity and recent formulations of interferon-induced depression have implicated neurotoxic influences which could also lead to changes in glutamate function. The present study used magnetic resonance spectroscopy (MRS) to measure both glutamate and its major metabolite, glutamine in patients with hepatitis C who received treatment with pegylated-interferon-α and ribavirin. Methods MRS measurements of glutamate and glutamine were taken from a 25×20×20mm voxel including pregenual anterior cingulate cortex in 12 patients before and after 4-6 weeks treatment with interferon. Results Interferon treatment led to an increase in cortical levels of glutamine (p= 0.02) and a significant elevation in the ratio of glutamine to glutamate (p<.01). Further, changes in glutamine level correlated significantly with ratings of depression and anxiety at the time of the second scan. Conclusions We conclude that treatment with interferon-α is associated with MRS-visible changes in glutamatergic metabolism. However, the changes seen differ from those reported in major depression which suggests that the pathophysiology of interferon-induced depression may be distinct from that of major depression more generally. PMID:23659574

Working for the People? Mrs Bridges Adams and the London School Board, 1897-1904.

ERIC Educational Resources Information Center

Martin, Jane

2000-01-01

Focuses on Mrs. Bridges Adams who was a supporter of state maintenance committed to educational opportunity for workers' children. Focuses on her political recruitment, her contribution to the work of the London School Board (England), and her role in the struggle to save the school board system. (CMK)

Washington, D.C.'s vanishing springs and waterways

USGS Publications Warehouse

Williams, Garnett P.

1977-01-01

This paper traces the disappearance or reduction of the many prominent springs and waterways that existed in Washington, D.C. , 200 years ago. The best known springs were the Smith Springs (now under the McMillan Reservoir), the Franklin Park Springs (13th and I Streets, NW.), Gibson 's Spring (15th and E Streets, NE.), Caffrey 's Spring (Ninth and F Streets, NW.), and the City Spring (C Street between Four and One-Half and Sixth Streets, NW.). Tiber Creek, flowing south to the Capitol and thence westward along Consititution Avenue, joined the Potomac River at 17th Street and Constitution Avenue. In the 1800's, the Constitution Avenue reach was made into a canal which was used by scows and steamboats up to about 1850. The canal was changed into a covered sewer in the 1870's, and the only remaining visible surface remnant is the lock-keeper 's little stone house at 17th and Constitution Avenue, NW. Because of sedimentation problems and reclamation projects, Rock Creek, the Potomac River , and the Anacostia River are considerably narrower and shallower today than they were in colonial times. For example, the mouth of Rock Creek at one time was a wide, busy ship harbor , which Georgetown used for an extensive foreign trade, and the Potomac River shore originally extended to 17th and Constitution Avenue, NW. (Woodard-USGS)

78 FR 54634 - U.S. Air Force Academy Board of Visitors Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-05

... Hall, United States Air Force Academy, in Colorado Springs CO on October 10- 11, 2013. The meeting will begin at 9:30 a.m. The purpose of this meeting is to review morale and discipline, social climate...

Audiomagnetotelluric data from Spring, Cave, and Coyote Spring Valleys, Nevada

USGS Publications Warehouse

McPhee, Darcy K.; Chuchel, Bruce A.; Pellerin, Louise

2006-01-01

Audiomagnetotelluric (AMT) data along four profiles in Spring, Cave, and Coyote Spring Valleys are presented here. The AMT method is used to estimate the electrical resistivity of the earth over depth ranges of a few meters to greater than one kilometer. This method is a valuable tool for revealing subsurface structure and stratigraphy within the Basin and Range of eastern Nevada, therefore helping to define the geohydrologic framework in this region. We collected AMT data using the Geometrics StrataGem EH4 system, a four-channel, natural and controlled- source tensor system recording in the range of 10 to 92,000 Hz. To augment the low signal in the natural field, an unpolarized transmitter comprised of two horizontal-magnetic dipoles was used from 1,000 to 70,000 Hz. Profiles were 1.4 - 12.6 km in length with station spacing of 100-400 m. Data were recorded with the electrical (E) field parallel to and perpendicular to the regional geologic strike direction. Station locations and sounding curves, showing apparent resistivity, phase data, and coherency data, are presented here.

Prevalence and Genetic Diversity of Enterococcus faecalis Isolates from Mineral Water and Spring Water in China.

PubMed

Wei, Lei; Wu, Qingping; Zhang, Jumei; Guo, Weipeng; Chen, Moutong; Xue, Liang; Wang, Juan; Ma, Lianying

2017-01-01

Enterococcus faecalis is an important opportunistic pathogen which is frequently detected in mineral water and spring water for human consumption and causes human urinary tract infections, endocarditis and neonatal sepsis. The aim of this study was to determine the prevalence, virulence genes, antimicrobial resistance and genetic diversity of E. faecalis from mineral water and spring water in China. Of 314 water samples collected from January 2013 to January 2014, 48 samples (15.3%) were contaminated E. faecalis . The highest contamination rate occurred in activated carbon filtered water of spring water (34.5%), followed by source water of spring water (32.3%) and source water of mineral water (6.4%). The virulence gene test of 58 E. faecalis isolates showed that the detection rates of asa1 , ace , cylA , gelE and hyl were 79.3, 39.7, 0, 100, 0%, respectively. All 58 E. faecalis isolates were not resistant to 12 kinds of antibiotics (penicillin, ampicillin, linezolid, quinupristin/dalfopristin, vancomycin, gentamicin, streptomycin, ciprofloxacin, levofloxacin, norfloxacin, nitrofurantoin, and tetracycline). Enterobacterial repetitive intergenic consensus-PCR classified 58 isolates and three reference strains into nine clusters with a similarity of 75%. This study is the first to investigate the prevalence of E. faecalis in mineral water and spring water in China. The results of this study suggested that spring water could be potential vehicles for transmission of E. faecalis .

Microbial Biosignatures in High Iron Thermal Springs

NASA Astrophysics Data System (ADS)

Parenteau, M. N.; Embaye, T.; Jahnke, L. L.; Cady, S. L.

2003-12-01

The emerging anoxic source waters at Chocolate Pots hot springs in Yellowstone National Park contain 2.6 to 11.2 mg/L Fe(II) and are 51-54° C and pH 5.5-6.0. These waters flow down the accumulating iron deposits and over three major phototrophic mat communities: Synechococcus/Chloroflexus at 51-54° C, Pseudanabaena at 51-54° C, and a narrow Oscillatoria at 36-45° C. We are assessing the contribution of the phototrophs to biosignature formation in this high iron system. These biosignatures can be used to assess the biological contribution to ancient iron deposits on Earth (e.g. Precambrian Banded Iron Formations) and, potentially, to those found on Mars. Most studies to date have focused on chemotrophic iron-oxidizing communities; however, recent research has demonstrated that phototrophs have a significant physiological impact on these iron thermal springs (Pierson et al. 1999, Pierson and Parenteau 2000, and Trouwborst et al., 2003). We completed a survey of the microfossils, biominerals, biofabrics, and lipid biomarkers in the phototrophic mats and stromatolitic iron deposits using scanning and transmission electron microscopy (SEM and TEM), energy dispersive spectrometry (EDS), powder X-ray diffraction (XRD), and gas chromatography-mass spectroscopy (GC-MS). The Synechococcus/Chloroflexus mat was heavily encrusted with iron silicates while the narrow Oscillatoria mat was encrusted primarily with iron oxides. Encrustation of the cells increased with depth in the mats. Amorphous 2-line ferrihydrite is the primary precipitate in the spring and the only iron oxide mineral associated with the mats. Goethite, hematite, and siderite were detected in dry sediment samples on the face of the main iron deposit. Analysis of polar lipid fatty acid methyl esters (FAME) generated a suite of lipid biomarkers. The Synechococcus/Chloroflexus mat contained two mono-unsaturated isomers of n-C18:1 with smaller amounts of polyunsaturated n-C18:2, characteristic of cyanobacteria

A natural tracer investigation of the hydrological regime of Spring Creek Springs, the largest submarine spring system in Florida

NASA Astrophysics Data System (ADS)

Dimova, Natasha T.; Burnett, William C.; Speer, Kevin

2011-04-01

This work presents results from a nearly two-year monitoring of the hydrologic dynamics of the largest submarine spring system in Florida, Spring Creek Springs. During the summer of 2007 this spring system was observed to have significantly reduced flow due to persistent drought conditions. Our examination of the springs revealed that the salinity of the springs' waters had increased significantly, from 4 in 2004 to 33 in July 2007 with anomalous high radon ( 222Rn, t1/2=3.8 days) in surface water concentrations indicating substantial saltwater intrusion into the local aquifer. During our investigation from August 2007 to May 2009 we deployed on an almost monthly basis a continuous radon-in-water measurement system and monitored the salinity fluctuations in the discharge area. To evaluate the springs' freshwater flux we developed three different models: two of them are based on water velocity measurements and either salinity or 222Rn in the associated surface waters as groundwater tracers. The third approach used only salinity changes within the spring area. The three models showed good agreement and the results confirmed that the hydrologic regime of the system is strongly correlated to local precipitation and water table fluctuations with higher discharges after major rain events and very low, even reverse flow during prolong droughts. High flow spring conditions were observed twice during our study, in the early spring and mid-late summer of 2008. However the freshwater spring flux during our observation period never reached that reported from a 1970s value of 4.9×10 6 m 3/day. The maximum spring flow was estimated at about 3.0×10 6 m 3/day after heavy precipitation in February-March 2008. As a result of this storm (total of 173 mm) the salinity in the spring area dropped from about 27 to 2 in only two days. The radon-in-water concentrations dramatically increased in parallel, from about 330 Bq/m 3 to about 6600 Bq/m 3. Such a rapid response suggests a direct

Estimation of evapotranspiration in the Rainbow Springs and Silver Springs basins in North-Central Florida

USGS Publications Warehouse

Knowles, Leel

1996-01-01

Estimates of evapotranspiration (ET) for the Rainbow and Silver Springs ground-water basins in north-central Florida were determined using a regional water-~budget approach and compared to estimates computed using a modified Priestley-Taylor (PT) model calibrated with eddy-correlation data. Eddy-correlation measurements of latent 0~E) and sensible (H) heat flux were made monthly for a few days at a time, and the PT model was used to estimate 3,E between times of measurement during the 1994 water year. A water-budget analysis for the two-basin area indicated that over a 30-year period (196594) annual rainfall was 51.7 inches. Of the annual rainfall, ET accounted for about 37.9 inches; springflow accounted for 13.1 inches; and the remaining 0.7 inch was accounted for by stream-flow, by ground-water withdrawals from the Floridan aquifer system, and by net change in storage. For the same 30-year period, the annual estimate of ET for the Silver Springs basin was 37.6 inches and was 38.5 inches for the Rainbow Springs basin. Wet- and dry-season estimates of ET for each basin averaged between nearly 19 inches and 20 inches, indicating that like rainfall, ET rates during the 4-month wet season were about twice the ET rates during the 8-month dry season. Wet-season estimates of ET for the Rainbow Springs and Silver Springs basins decreased 2.7 inches, and 3.4 inches, respectively, over the 30-year period; whereas, dry-season estimates for the basins decreased about 0.4 inch and1.0 inch, respectively, over the 30-year period. This decrease probably is related to the general decrease in annual rainfall and reduction in net radiation over the basins during the 30-year period. ET rates computed using the modified PT model were compared to rates computed from the water budget for the 1994 water year. Annual ET, computed using the PT model, was 32.0 inches, nearly equal to the ET water-budget estimate of 31.7 inches computed for the Rainbow Springs and Silver Springs basins

Siliceous Shrubs in Yellowstone's Hot Springs: Implications for Exobiological Investigations

NASA Technical Reports Server (NTRS)

Guidry, S. A.; Chafetz, H. S.

2003-01-01

Potential relict hot springs have been identified on Mars and, using the Earth as an analog, Martian hot springs are postulated to be an optimal locality for recognizing preserved evidence of extraterrestrial life. Distinctive organic and inorganic biomarkers are necessary to recognize preserved evidence of life in terrestrial and extraterrestrial hot spring accumulations. Hot springs in Yellowstone National Park, Wyoming, U.S.A., contain a wealth of information about primitive microbial life and associated biosignatures that may be useful for future exobiological investigations. Numerous siliceous hot springs in Yellowstone contain abundant, centimeter-scale, spinose precipitates of opaline silica (opal-A). Although areally extensive in siliceous hot spring discharge channel facies, these spinose forms have largely escaped attention. These precipitates referred to as shrubs, consist of porous aggregates of spinose opaline silica that superficially resemble miniature woody plants, i.e., the term shrubs. Shrubs in carbonate precipitating systems have received considerable attention, and represent naturally occurring biotically induced precipitates. As such, shrubs have great potential as hot spring environmental indicators and, more importantly, proxies for pre-existing microbial life.

The Dependence of the Spring Constant in the Linear Range on Spring Parameters

ERIC Educational Resources Information Center

Khotimah, Siti Nurul; Viridi, Sparisoma; Widayani; Khairurrijal

2011-01-01

In basic physics laboratories, springs are normally used to determine both spring constants and the Earth's gravitational acceleration. Students generally do not notice that the spring constant is not a universal constant, but depends on the spring parameters. This paper shows and verifies that the spring constant in the linear range is inversely…

Prediction of chemotherapeutic response of colorectal liver metastases with dynamic gadolinium-DTPA-enhanced MRI and localized 19F MRS pharmacokinetic studies of 5-fluorouracil.

PubMed

van Laarhoven, H W M; Klomp, D W J; Rijpkema, M; Kamm, Y L M; Wagener, D J Th; Barentsz, J O; Punt, C J A; Heerschap, A

2007-04-01

Systemic chemotherapy is effective in only a subset of patients with metastasized colorectal cancer. Therefore, early selection of patients who are most likely to benefit from chemotherapy is desirable. Response to treatment may be determined by the delivery of the drug to the tumor, retention of the drug in the tumor and by the amount of intracellular uptake, metabolic activation and catabolism, as well as other factors. The first aim of this study was to investigate the predictive value of DCE-MRI with the contrast agent Gd-DTPA for tumor response to first-line chemotherapy in patients with liver metastases of colorectal cancer. The second aim was to investigate the predictive value of 5-fluorouracil (FU) uptake, retention and catabolism as measured by localized (19)F MRS for tumor response to FU therapy. Since FU uptake, retention and metabolism may depend on tumor vascularization, the relationship between (19)F MRS and the DCE-MRI parameters k(ep), K(trans) and v(e) was also examined (1). In this study, 37 patients were included. The kinetic parameters of DCE-MRI, k(ep), K(trans) and v(e), before start of treatment did not predict tumor response after 2 months, suggesting that the delivery of chemotherapy by tumor vasculature is not a major factor determining response in first-line treatment. No evident correlations between (19)F MRS parameters and tumor response were found. This suggests that in liver metastases that are not selected on the basis of their tumor diameter, FU uptake and catabolism are not limiting factors for response. The transfer constant K(trans), as measured by DCE-MRI before start of treatment, was negatively correlated with FU half-life in the liver metastases, which suggests that, in metastases with a larger tumor blood flow or permeability surface area product, FU is rapidly washed out from the tumor. c 2006 John Wiley & Sons, Ltd.

75 FR 20984 - Mid-Atlantic Fishery Management Council (MAFMC); Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-22

... Commission Spring Meeting, Crowne Plaza Old Town Alexandria, 901 N. Fairfax St., Alexandria, VA 22314. The... accessible to people with disabilities. Requests for sign language interpretation or other auxiliary aids...

Fossilization Processes in Thermal Springs

NASA Technical Reports Server (NTRS)

Farmer, Jack D.; Cady, Sherry; Desmarais, David J.; Chang, Sherwood (Technical Monitor)

1995-01-01

To create a comparative framework for the study of ancient examples, we have been carrying out parallel studies of the microbial biosedimentology, taphonomy and geochemistry of modem and sub-Recent thermal spring deposits. One goal of the research is the development of integrated litho- and taphofacies models for siliceous and travertline sinters. Thermal springs are regarded as important environments for the origin and early evolution of life on Earth, and we seek to utilize information from the fossil record to reconstruct the evolution of high temperature ecosystems. Microbial contributions to the fabric of thermal spring sinters occur when population growth rates keep pace with, or exceed rates of inorganic precipitation, allowing for the development of continuous biofilms or mats. In siliceous thermal springs, microorganisms are typically entombed while viable. Modes of preservation reflect the balance between rates of organic matter degradation, silica precipitation and secondary infilling. Subaerial sinters are initially quite porous and permeable and at temperatures higher than about 20 C, organic materials are usually degraded prior to secondary infilling of sinter frameworks. Thus, organically-preserved microfossils are rare and fossil information consists of characteristic biofabrics formed by the encrustation and underplating of microbial mat surfaces. This probably accounts for the typically low total organic carbon values observed in thermal spring deposits. In mid-temperature, (approx. 35 - 59 C) ponds and outflows, the surface morphology of tufted Phormidium mats is preserved through mat underplating by thin siliceous: crusts. Microbial taxes lead to clumping of ceils and/or preferred filament orientations that together define higher order composite fabrics in thermal spring stromatolites (e.g. network, coniform, and palisade). At lower temperatures (less than 35 C), Calothrix mats cover shallow terracette pools forming flat carpets or pustular

Modeling and Evaluation of Canted Coil Springs as High Temperature Seal Preloading Devices

NASA Technical Reports Server (NTRS)

Oswald, Jay J.; Mullen, Robert L.; Dunlap, Patrick H., Jr.; Steinetz, Bruce M.

2004-01-01

Future reusable launch vehicles will require advanced structural seals. This includes propulsion seals along edges and hinge lines in hypersonic engines, and control surface seals for movable flaps and elevons on proposed reentry vehicles. Seals must remain in sealing engagement with opposing surfaces, for multiple missions, even though the seal gap may be opening and closing due to thermal and structural loads. To meet this requirement either the seals themselves must be resilient or there must be a resilient structural element behind the seals. Case Western Reserve University is working with NASA s Glenn Research Center to develop more resilient high temperature seal components and preloading devices. Results are presented for a finite element analysis of a canted coil spring that is being considered as a high temperature seal preloading device. This type of spring is a leading candidate due to its ability to provide nearly constant force over a large deflection. The finite element analyses were verified by comparing them to experimental results of canted coil springs of three different stiffnesses, measured at Glenn Research Center. Once validated the parameterized model was combined with a scripting algorithm to assess the effects of key spring design variables (wire diameter, coils per inch, cant amplitude, eccentricity, and spring width) on spring stiffness and maximum Von Mises stress to aid in subsequent design.

77 FR 5798 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-06

... B. New Business Spring 2012 Abstract of the Unified Agenda of Federal Regulatory and Deregulatory... McLean, Virginia, on February 9, 2012, from 9 a.m. until such time as the Board concludes its business..., McLean, Virginia 22102-5090. SUPPLEMENTARY INFORMATION: Parts of this meeting of the Board will be open...

Database of historically documented springs and spring flow measurements in Texas

USGS Publications Warehouse

Heitmuller, Franklin T.; Reece, Brian D.

2003-01-01

Springs are naturally occurring features that convey excess ground water to the land surface; they represent a transition from ground water to surface water. Water issues through one opening, multiple openings, or numerous seeps in the rock or soil. The database of this report provides information about springs and spring flow in Texas including spring names, identification numbers, location, and, if available, water source and use. This database does not include every spring in Texas, but is limited to an aggregation of selected digital and hard-copy data of the U.S. Geological Survey (USGS), the Texas Water Development Board (TWDB), and Capitol Environmental Services.

Valve-spring Surge

NASA Technical Reports Server (NTRS)

Marti, Willy

1937-01-01

Test equipment is described that includes a system of three quartz indicators whereby three different pressures could be synchronized and simultaneously recorded on a single oscillogram. This equipment was used to test the reliction of waves at ends of valve spring, the dynamical stress of the valve spring for a single lift of the valve, and measurement of the curve of the cam tested. Other tests included simultaneous recording of the stress at both ends of the spring, spring oscillation during a single lift as a function of speed, computation of amplitude of oscillation for a single lift by harmonic analysis, effect of cam profile, the setting up of resonance, and forced spring oscillation with damping.

Nonthermal springs of Utah

USGS Publications Warehouse

Mundorff, J.C.

1971-01-01

Data are presented for about 4,500 nonthermal springs that discharge in the State of Utah. Most major springs having discharge of several cubic feet per second or more are in or near mountain ranges or plateaus where precipitation is much greater than in other parts of the State. The largest instantaneous discharge observed at any spring was 314 cfs at Mammoth Spring in southwestern Utah.  Discharges exceeding 200 cfs have been observed at Swan Creek Spring in extreme northern Utah, and discharges of 200 cfs have been reported for Big Brush Creek Spring in northeastern Utah. Maximum discharges generally are during or within a few weeks after the main period of snowmelt, which is usually from late April to the middle of June.The largest springs generally discharge form or very near carbonate rocks in which solution channels and fractures are numerous or from areas of porous or fractured volcanic rocks. Most nonthermal springs in Utah probably are variable springs – that is, their variability of discharge exceeds 100 percent.Most of the major springs discharge water that contains less than 500 ppm (parts per million) of dissolved solids, and most of the water is of the calcium bicarbonate type. Water from springs is used for domestic, municipal, irrigation, livestock, mining, and industrial purposes.

78 FR 11877 - Announcement of Requirements Gathering Meetings for the Electronic Manifest (e-Manifest) System

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-20

... Gathering Meetings for the Electronic Manifest (e-Manifest) System AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of public meetings. SUMMARY: EPA's Office of Resource Conservation and Recovery...'') system to capture information regarding the shipment of hazardous waste from the time it leaves the...

2014 Materials Research Society (MRS) Spring Meeting (4/21-25/14), Moscone West Convention Center, San Francisco CA

DTIC Science & Technology

2015-04-02

optical communications . Yet, the lack of a general theoretical framework able to anticipate over the whole visible spectrum and with high accuracy the...detection, as well as new avenues for largely transparent tunable isolators for optical communications . [1] G. Armelles et al., Adv. Optical Mater. 2013...coefficients that are simultaneously equal to or greater than unity can all be achieved with increasing PT-symmetric potentials. We then use a dyadic Green’s

Proton magnetic resonance spectroscopy (MRS) in on-line game addiction

PubMed Central

Han, Doug Hyun; Lee, Young Sik; Shi, Xianfeng; Renshaw, Perry F.

2015-01-01

Recent brain imaging studies suggested that both the frontal and temporal cortices are important candidate areas for mediating the symptoms of internet addiction. We hypothesized that deficits of prefrontal and temporal cortical function in patients with on-line game addiction (PGA) would be reflected in decreased levels of N-acetyl aspartate (NAA) and cytosolic, choline containing compound (Cho). Seventy three young PGA and 38 age and sex matched healthy control subjects were recruited in the study. Structural MR and 1H MRS data were acquired using a 3.0 T MRI scanner. Voxels were sequentially placed in right frontal cortex and right medial temporal cortices. In the right frontal cortex, the levels of NAA in PGA were lower than those in healthy controls. In the medial temporal cortex, the levels of Cho in PGA participants were lower than those observed in healthy controls. The Young Internet Addiction Scale (YIAS) scores and perseverative responses in PGA were negatively correlated with the level of NAA in right frontal cortex. The Beck Depressive Inventory (BDI) scores in the PGA cohort were negatively correlated with Cho levels in the right temporal lobe. To the best of our knowledge, this is the first MRS study of individuals with on-line game addiction. Although, the subjects with on-line game addiction in the current study were free from psychiatric co-morbidity, patients with on-line game addiction appear to share characteristics with ADHD and MDD in terms of neurochemical changes in frontal and temporal cortices. PMID:25088284

Proton magnetic resonance spectroscopy (MRS) in on-line game addiction.

PubMed

Han, Doug Hyun; Lee, Young Sik; Shi, Xianfeng; Renshaw, Perry F

2014-11-01

Recent brain imaging studies suggested that both the frontal and temporal cortices are important candidate areas for mediating the symptoms of internet addiction. We hypothesized that deficits of prefrontal and temporal cortical function in patients with on-line game addiction (PGA) would be reflected in decreased levels of N-acetyl aspartate (NAA) and cytosolic, choline containing compound (Cho). Seventy three young PGA and 38 age and sex matched healthy control subjects were recruited in the study. Structural MR and (1)H MRS data were acquired using a 3.0 T MRI scanner. Voxels were sequentially placed in right frontal cortex and right medial temporal cortices. In the right frontal cortex, the levels of NAA in PGA were lower than those in healthy controls. In the medial temporal cortex, the levels of Cho in PGA participants were lower than those observed in healthy controls. The Young Internet Addiction Scale (YIAS) scores and perseverative responses in PGA were negatively correlated with the level of NAA in right frontal cortex. The Beck Depressive Inventory (BDI) scores in the PGA cohort were negatively correlated with Cho levels in the right temporal lobe. To the best of our knowledge, this is the first MRS study of individuals with on-line game addiction. Although, the subjects with on-line game addiction in the current study were free from psychiatric co-morbidity, patients with on-line game addiction appear to share characteristics with ADHD and MDD in terms of neurochemical changes in frontal and temporal cortices. Copyright © 2014 Elsevier Ltd. All rights reserved.

2. Historic American Buildings Survey E. W. Russell, Photographer, August ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey E. W. Russell, Photographer, August 23, 1936 CLOSE- UP BALUSTRADE SHOWING LOWER PART CORNER STANDARD E. END, FIRST FLOOR. MRS. ALBERT QUIGLEY - 751 GOVERNMENT ST. - Gilmore-Gaines-Quigley House, 751 Government Street, Mobile, Mobile County, AL

Stratospheric balloon observations of comets C/2013 A1 (Siding Spring), C/2014 E2 (Jacques), and Ceres

NASA Astrophysics Data System (ADS)

Cheng, Andrew F.; Hibbitts, C. A.; Espiritu, R.; McMichael, R.; Fletcher, Z.; Bernasconi, P.; Adams, J. D.; Lisse, C. M.; Sitko, M. L.; Fernandes, R.; Young, E. F.; Kremic, T.

2017-01-01

The Balloon Observation Platform for Planetary Science (BOPPS) was launched from Fort Sumner, New Mexico on September 26, 2014 and observed Oort Cloud comets from a stratospheric balloon observatory, using a 0.8 meter aperture telescope, a pointing system that achieved < 1 arc second pointing stability, and an imaging instrument suite covering the near-ultraviolet to mid-infrared. BOPPS observed two Oort Cloud comets, C/2013 A1 (Siding Spring) and C/2014 E2 (Jacques), at the 2.7 μm wavelength of water emission. BOPPS also observed Ceres at 2.7 μm wavelength to characterize the nature of hydrated materials on Ceres. Absolute flux calibrations were made using observations of A0V stars at nearly the same elevations as each target. The Comet Siding Spring brightness in R-band was magnitude R = 10.8 in a photometric aperture of 17.4″. The inferred H2O production rate from Comet Siding Spring was 6 × 1027 s-1, assuming optically thin emissions, which may be a lower limit if optical depth effects are important. A superheat dust population was discovered at Comet Jacques, producing a bright infrared continuum without evidence for line emission. Observations of Ceres from BOPPS and from IRTF, obtained the same night, did not find evidence for a strong water vapor emission near 2.7 μm and led to an approximate upper limit < 7 × 1027 s-1 for water emission from Ceres.

Extracellular synthesis and characterization of nickel oxide nanoparticles from Microbacterium sp. MRS-1 towards bioremediation of nickel electroplating industrial effluent.

PubMed

Sathyavathi, S; Manjula, A; Rajendhran, J; Gunasekaran, P

2014-08-01

In the present study, a nickel resistant bacterium MRS-1 was isolated from nickel electroplating industrial effluent, capable of converting soluble NiSO4 into insoluble NiO nanoparticles and identified as Microbacterium sp. The formation of NiO nanoparticles in the form of pale green powder was observed on the bottom of the flask upon prolonged incubation of liquid nutrient medium containing high concentration of 2000ppm NiSO4. The properties of the produced NiO nanoparticles were characterized. NiO nanoparticles exhibited a maximum absorbance at 400nm. The NiO nanoparticles were 100-500nm in size with unique flower like structure. The elemental composition of the NiO nanoparticles was 44:39. The cells of MRS-1 were utilized for the treatment of nickel electroplating industrial effluent and showed nickel removal efficiency of 95%. Application of Microbacterium sp. MRS-1 would be a potential bacterium for bioremediation of nickel electroplating industrial waste water and simultaneous synthesis of NiO nanoparticles. Copyright © 2014 Elsevier Ltd. All rights reserved.

78 FR 19304 - Notice of Intent To Repatriate Cultural Items: The Colorado College, Colorado Springs, CO

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-29

..., Armstrong Hall, Room 201, 14 E. Cache La Poudre, Colorado Springs, CO 80903, telephone (719) 389-6201..., Room 201, 14 E. Cache La Poudre, Colorado Springs, CO 80903, telephone (719) 389-6201, before April 29...

17 O MRS assesses the effect of mild hypothermia on oxygen consumption rate in tumors.

PubMed

Neveu, Marie-Aline; Joudiou, Nicolas; De Preter, Géraldine; Dehoux, Jean-Paul; Jordan, Bénédicte F; Gallez, Bernard

2017-08-01

Although oxygen consumption is a key factor in metabolic phenotyping, its assessment in tumors remains critical, as current technologies generally display poor specificity. The objectives of this study were to explore the feasibility of direct 17 O nuclear magnetic resonance (NMR) spectroscopy to assess oxygen metabolism in tumors and its modulations. To investigate the impact of hypometabolism induction in the murine fibrosarcoma FSAII tumor model, we monitored the oxygen consumption of normothermic (37°C) and hypothermic (32°C) tumor-bearing mice. Hypothermic animals showed an increase in tumor pO 2 (measured by electron paramagnetic resonance oximetry) contrary to normothermic animals. This was related to a decrease in oxygen consumption rate (assessed using 17 O magnetic resonance spectroscopy (MRS) after the inhalation of 17 O 2 -enriched gas). This study highlights the ability of direct 17 O MRS to measure oxygen metabolism in tumors and modulations of tumor oxygen consumption rate. Copyright © 2017 John Wiley & Sons, Ltd.

Mrs. Chandrasekhar poses with model of the Chandra X-ray Observatory

NASA Technical Reports Server (NTRS)

1999-01-01

Mrs. Lalitha Chandrasekhar, wife of the late Indian-American Nobel Laureate Subrahmanyan Chandrasekhar, poses with a model of the Chandra X-ray Observatory in the TRW Media Hospitality Tent at the NASA Press Site at KSC. The name 'Chandra,' a shortened version of Chandrasekhar's name which he preferred among friends and colleagues, was chosen in a contest to rename the telescope. 'Chandra' also means 'Moon' or 'luminous' in Sanskrit. The observatory is scheduled to be launched aboard Columbia on Space Shuttle mission STS-93.

Leveraging the Value of Human Relationships to Improve Health Outcomes. Lessons learned from the OpenMRS Electronic Health Record System.

PubMed

Kasthurirathne, Suranga N; Mamlin, Burke W; Cullen, Theresa

2017-02-01

Despite significant awareness on the value of leveraging patient relationships across the healthcare continuum, there is no research on the potential of using Electronic Health Record (EHR) systems to store structured patient relationship data, or its impact on enabling better healthcare. We sought to identify which EHR systems supported effective patient relationship data collection, and for systems that do, what types of relationship data is collected, how this data is used, and the perceived value of doing so. We performed a literature search to identify EHR systems that supported patient relationship data collection. Based on our results, we defined attributes of an effective patient relationship model. The Open Medical Record System (OpenMRS), an open source medical record platform for underserved settings met our eligibility criteria for effective patient relationship collection. We performed a survey to understand how the OpenMRS patient relationship model was used, and how it brought value to implementers. The OpenMRS patient relationship model has won widespread adoption across many implementations and is perceived to be valuable in enabling better health care delivery. Patient relationship information is widely used for community health programs and enabling chronic care. Additionally, many OpenMRS implementers were using this feature to collect custom relationship types for implementation specific needs. We believe that flexible patient relationship data collection is critical for better healthcare, and can inform community care and chronic care initiatives across the world. Additionally, patient relationship data could also be leveraged for many other initiatives such as patient centric care and in the field of precision medicine.

Major thermal springs of Utah

USGS Publications Warehouse

Mundorff, J.C.

1970-01-01

As part of a study of the springs of Utah, reconnaissance data were obtained on the thermal, chemical, and geologic characteristics of the major thermal springs or Utah. Only three of the springs have temperatures near the boiling point of water; the maximum recorded temperatures of these springs range from 185° to 189° F. All three springs are in or near areas of late Tertiary or Quaternary volcanism.Temperatures of the thermal springs studied ranged from 68° to 189° F. Nearly all thermal springs in Utah are in or near fault zones. Very few of these springs issue from volcanic rocks, but several springs are close to areas of late Tertiary or Quaternary volcanic rocks.

The Fourth Joint Meeting of the AAS and ASP, Victoria, June 1952

NASA Astrophysics Data System (ADS)

Garstang, R. H.

1999-05-01

This meeting was my most memorable because (1) it was the first AAS meeting to be held in Western Canada, (2) it was my first visit to Canada, (3) it was the occasion of the dedication of the Dominion Astrophysical Observatory 72-inch telescope to the memory of J. S. Plaskett, in the presence of Mrs. Plaskett, (4) there was a special symposium on emission line stars, which included a lecture by Paul Merrill to celebrate his retirement, and C. S. Beals and J. A. Rottenberg as the other main speakers, (5) Robert McMath gave the first Aitken lecture in memory of the famous double star astronomer, (6) I was elected a member of the AAS by the Council at this meeting, (7) I was already a member of the ASP, and this was my first opportunity to present a paper at an ASP meeting, and I could choose to put my abstract in the P.A.S.P., (8) I met many astronomers there who have been friends ever since, (9) along with many attendees I visited Butchart's Gardens, and (10) there was an excellent banquet at the Empress Hotel.

75 FR 53665 - Hydrographic Services Review Panel Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-01

..., National Ocean Service (NOS), NOAA (N/CS), 1315 East West Highway, Silver Spring, Maryland 20910; Telephone... Review Panel Meeting AGENCY: National Ocean Service, National Oceanic and Atmospheric Administration..., National Ocean Service, National Oceanic and Atmospheric Administration. [FR Doc. 2010-21882 Filed 8-31-10...

Rebuilding the injured brain: use of MRS in clinical regenerative medicine

NASA Astrophysics Data System (ADS)

Zare, Alina; Weiss, Michael; Gader, Paul

2011-03-01

Hypoxic-Ischemic Encephalopathy (HIE) is the brain manifestation of systemic asphyxia that occurs in 20 out of 1000 births. HIE triggers an immediate neuronal and glial injury leading to necrosis secondary to cellular edema and lysis. Because of this destructive neuronal injury, up to 25% of neonates exhibit severe permanent neuropsychological handicaps in the form of cerebral palsy, with or without associated mental retardation, learning disabilities, or epilepsy. Due to the devastating consequences of HIE, much research has focused on interrupting the cascade of events triggered by HIE. To date, none of these therapies, with the exception of hypothermia, have been successful in the clinical environment. Even in the case of hypothermia, only neonates with mild to moderate HIE respond to therapy. Stem cell therapy offers an attractive potential treatment for HIE. The ability to replace necrotic cells with functional cells could limit the degree of long-term neurological deficits. The neonatal brain offers a unique milieu for stem cell therapy due to its overall plasticity and the continued division of cells in the sub-ventricular zones. New powerful imaging tools allow researchers to track stem cells in vivo post-transplant, as shown in Figure 1. However, neuroimaging still leaves numerous questions unresolved: How can we identify stem cells without using tracking agents, what cells types are destroyed in the brain post injury? What is the final phenotypic fate of transplanted cells? Are the transplanted cells still viable? Do the transplanted cells spare endogenous neuronal tissue? We hypothesize that magnetic resonance spectroscopy (MRS), a broadly used clinical technique that can be performed at the time of a standard MRI scan, can provide answers to these questions when coupled with advanced computational approaches. MRS is widely available clinically, and is a relative measure of different metabolites within the sampled area. These measures are presented as a

Mrs. O'Leary's Cow and Other Newspaper Tales about the Chicago Fire of 1871.

ERIC Educational Resources Information Center

Fedler, Fred

Noting that, historically, newspaper editors copied the best, and sometimes erroneous, stories from other newspapers published in distant cities, this paper explores newpaper coverage of the 1871 Great Chicago Fire, and the myth that Mrs. O'Leary's cow was to blame. After suggesting that a report invented the story of the O'Leary cow kicking a…

78 FR 58534 - Warm Springs Irrigation District; Notice of Technical Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-24

... confertiflora requested by the U.S. Bureau of Land Management on June 7, 2013; the coordination of the National... Agenda: 1. Introduction. 2. Meeting objectives. 3. Plant survey discussion. 4. NEPA coordination. 5...

Deformation of nickel-titanium closed coil springs: an in vitro study.

PubMed

Vieira, Camilla Ivini Viana; Reis, José Maurício Dos Santos Nunes; Vaz, Luiz Geraldo; Martins, Lídia Parsekian; Martins, Renato Parsekian

2017-02-01

The aim of this paper was to determine the amount of deformation in four commercial brands of nickel-titanium closed springs. A total of 130 springs were divided into 13 subgroups, according to their features and manufacturers (Morelli, Orthometric, Ormco and GAC) and activated from 100% to 1000% of the effective length of the nickel-titanium portion present at the spring, at 37 °C. Deactivation data were plotted and deformation was found graphically. The values were compared by analysis of variance and Tukey's post-hoc test. Springs manufactured by Morelli had the same amount of deformation when they were activated up to 700% of Y activation; springs by Orthometric had the same amount of deformation up to 600-700% of Y; springs by Ormco had the same amount of deformation up to 700-800% of Y; and finally, the majority of springs by GAC had similar deformation up to 800%-1000% of activation. All springs tested could be activated up to 700% without rupture. Most subgroups were similarly deformed up to 700% of activation, without rupture of springs. Subgroups 4B, 4C, 4D and 4E showed the same amount of deformation up to 1000% of activation without any rupture at all.

Deformation of nickel-titanium closed coil springs: an in vitro study

PubMed Central

Vieira, Camilla Ivini Viana; Reis, José Maurício dos Santos Nunes; Vaz, Luiz Geraldo; Martins, Lídia Parsekian; Martins, Renato Parsekian

2017-01-01

ABSTRACT Objective: The aim of this paper was to determine the amount of deformation in four commercial brands of nickel-titanium closed springs. Methods: A total of 130 springs were divided into 13 subgroups, according to their features and manufacturers (Morelli, Orthometric, Ormco and GAC) and activated from 100% to 1000% of the effective length of the nickel-titanium portion present at the spring, at 37 °C. Deactivation data were plotted and deformation was found graphically. The values were compared by analysis of variance and Tukey's post-hoc test. Results: Springs manufactured by Morelli had the same amount of deformation when they were activated up to 700% of Y activation; springs by Orthometric had the same amount of deformation up to 600-700% of Y; springs by Ormco had the same amount of deformation up to 700-800% of Y; and finally, the majority of springs by GAC had similar deformation up to 800%-1000% of activation. All springs tested could be activated up to 700% without rupture. Conclusions: Most subgroups were similarly deformed up to 700% of activation, without rupture of springs. Subgroups 4B, 4C, 4D and 4E showed the same amount of deformation up to 1000% of activation without any rupture at all. PMID:28444020

Springing into Spring: Reading Games for the Season

ERIC Educational Resources Information Center

Maxwell, D. Jackson

2008-01-01

As spring arrives, more time is spent outdoors. Unfortunately, as spring fever hits, books and learning often take a backseat. The goal is for educators to find a way to re-engage learners. In this article, the author presents a seasonal story and game that can help catch students' attention by making learning both informative and entertaining.…

1H MRS spectroscopy in preclinical autosomal dominant Alzheimer disease.

PubMed

Joe, Elizabeth; Medina, Luis D; Ringman, John M; O'Neill, Joseph

2018-06-16

1 H magnetic resonance spectroscopy (MRS) can reveal changes in brain biochemistry in vivo in humans and has been applied to late onset Alzheimer disease (AD). Carriers of mutations for autosomal dominant Alzheimer disease (ADAD) may show changes in levels of metabolites prior to the onset of clinical symptoms. Proton MR spectra were acquired at 1.5 T for 16 cognitively asymptomatic or mildly symptomatic mutation carriers (CDR < 1) and 11 non-carriers as part of a comprehensive cross-sectional study of preclinical ADAD. Levels of N-acetyl-aspartate+N-acetyl-aspartyl-glutamate (NAA), glutamate/glutamine (Glx), creatine/phosphocreate (Cr), choline (Cho), and myo-inositol (mI) in the left and right anterior cingulate and midline posterior cingulate and precuneus were compared between mutation carriers (MCs) and non-carriers (NCs) using multivariate analysis of variance with age as a covariate. Among MCs, correlations between metabolite levels and time until expected age of dementia diagnosis were calculated. MCs had significantly lower levels of NAA and Glx in the left pregenual anterior cingulate cortex, and lower levels of NAA and higher levels of mI and Cho in the precuneus compared to NCs. Increased levels of mI were seen in these regions in association with increased proximity to expected age of dementia onset. MRS shows effects of ADAD similar to those seen in late onset AD even during the preclinical period including lower levels of NAA and higher levels of mI. These indices of neuronal and glial dysfunction might serve as surrogate outcome measures in prevention studies of putative disease-modifying agents.

Copyright and Related Protections for Information Age Products. Proceedings and Related Documents of the Meeting of the Information Industry Association (Airlie House, Virginia on July 18 & 19, 1969).

ERIC Educational Resources Information Center

Information Industry Association, Washington, DC.

The welcome and reasons for the meeting, presented by Mr. William T. Knox is followed by these papers: (1) Copyright in Its Historical and Philosophic Setting by Miss Barbara Ringer; (2) Copyright and Standard Reference Data Publications by Dr. Ed Brady; (3) Copyright Revision - Issues and Interests by Mrs. Bella Linden; (4) Court of Claims and…

In vivo mouse myocardial (31)P MRS using three-dimensional image-selected in vivo spectroscopy (3D ISIS): technical considerations and biochemical validations.

PubMed

Bakermans, Adrianus J; Abdurrachim, Desiree; van Nierop, Bastiaan J; Koeman, Anneke; van der Kroon, Inge; Baartscheer, Antonius; Schumacher, Cees A; Strijkers, Gustav J; Houten, Sander M; Zuurbier, Coert J; Nicolay, Klaas; Prompers, Jeanine J

2015-10-01

(31)P MRS provides a unique non-invasive window into myocardial energy homeostasis. Mouse models of cardiac disease are widely used in preclinical studies, but the application of (31)P MRS in the in vivo mouse heart has been limited. The small-sized, fast-beating mouse heart imposes challenges regarding localized signal acquisition devoid of contamination with signal originating from surrounding tissues. Here, we report the implementation and validation of three-dimensional image-selected in vivo spectroscopy (3D ISIS) for localized (31)P MRS of the in vivo mouse heart at 9.4 T. Cardiac (31)P MR spectra were acquired in vivo in healthy mice (n = 9) and in transverse aortic constricted (TAC) mice (n = 8) using respiratory-gated, cardiac-triggered 3D ISIS. Localization and potential signal contamination were assessed with (31)P MRS experiments in the anterior myocardial wall, liver, skeletal muscle and blood. For healthy hearts, results were validated against ex vivo biochemical assays. Effects of isoflurane anesthesia were assessed by measuring in vivo hemodynamics and blood gases. The myocardial energy status, assessed via the phosphocreatine (PCr) to adenosine 5'-triphosphate (ATP) ratio, was approximately 25% lower in TAC mice compared with controls (0.76 ± 0.13 versus 1.00 ± 0.15; P < 0.01). Localization with one-dimensional (1D) ISIS resulted in two-fold higher PCr/ATP ratios than measured with 3D ISIS, because of the high PCr levels of chest skeletal muscle that contaminate the 1D ISIS measurements. Ex vivo determinations of the myocardial PCr/ATP ratio (0.94 ± 0.24; n = 8) confirmed the in vivo observations in control mice. Heart rate (497 ± 76 beats/min), mean arterial pressure (90 ± 3.3 mmHg) and blood oxygen saturation (96.2 ± 0.6%) during the experimental conditions of in vivo (31)P MRS were within the normal physiological range. Our results show that respiratory-gated, cardiac-triggered 3D ISIS allows for non-invasive assessments of in vivo

Fluorine (19F) MRS and MRI in biomedicine

PubMed Central

Ruiz-Cabello, Jesús; Barnett, Brad P.; Bottomley, Paul A.; Bulte, Jeff W.M.

2011-01-01

Shortly after the introduction of 1H MRI, fluorinated molecules were tested as MR-detectable tracers or contrast agents. Many fluorinated compounds, which are nontoxic and chemically inert, are now being used in a broad range of biomedical applications, including anesthetics, chemotherapeutic agents, and molecules with high oxygen solubility for respiration and blood substitution. These compounds can be monitored by fluorine (19F) MRI and/or MRS, providing a noninvasive means to interrogate associated functions in biological systems. As a result of the lack of endogenous fluorine in living organisms, 19F MRI of ‘hotspots’ of targeted fluorinated contrast agents has recently opened up new research avenues in molecular and cellular imaging. This includes the specific targeting and imaging of cellular surface epitopes, as well as MRI cell tracking of endogenous macrophages, injected immune cells and stem cell transplants. PMID:20842758

Publication Rates of Abstracts Presented at Five National Pharmacy Association Meetings

PubMed Central

Prohaska, Emily; Generali, Joyce; Zak, Kevin; Grauer, Dennis

2013-01-01

Background: Abstract presentations at professional meetings provide a medium for disseminating the findings of scholarly activity. Rates of abstract publication from various biomedical disciplines have been evaluated, with pharmacy noted to be lower than other specialties. Previous research on pharmacy abstract publication rates was conducted for a limited number of professional meetings but has not been assessed using Google Scholar. Objective: To determine the full publication rate of abstracts presented at the 2005 American College of Clinical Pharmacy (ACCP) Spring and Annual Meetings, American Pharmacists Association (APhA) Annual Meeting, and American Society of Health-System Pharmacists (ASHP) Summer and Midyear Clinical Meetings. Methods: Publication status was assessed for abstracts presented during the 2005 ACCP Spring and Annual Meetings, APhA Annual Meeting, and ASHP Summer and Midyear Clinical Meetings using PubMed and Google Scholar. Data collected included abstract category, study category, practice site, database(s) in which publication appeared, time in months to publication, publication type, and journal of publication. Results: Evaluation of 2,000 abstracts presented in 2005 revealed an overall full publication rate of 19.8% (n = 384). Nearly all pharmacy abstracts were published as manuscripts (98.4%; n=378) and indexed in PubMed and Google Scholar (91.9%; n = 353), although a significant percentage were indexed in Google Scholar only (7.8%; n = 30). The mean time to full publication was 16.8 months (SD ±11.9 months). Conclusions: Results were consistent with previously reported full publication rates of abstracts from pharmacy association meetings, indicating that abstracts presented at pharmacy meetings continue to have a lower full publication rate than other health disciplines. PMID:24421465

77 FR 9958 - Spring Pygmy Sunfish Candidate Conservation Agreement With Assurances; Receipt of Application for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-21

...-FF04E00000] Spring Pygmy Sunfish Candidate Conservation Agreement With Assurances; Receipt of Application for Enhancement of Survival Permit; Beaverdam Springs, Limestone County, AL AGENCY: Fish and Wildlife Service..., the Land Trust of Huntsville and North Alabama, and the Service for the spring pygmy sunfish. The CCAA...

Mrs. Chandrasekhar addresses the media in TRW Media Hospitality Tent

NASA Technical Reports Server (NTRS)

1999-01-01

Mrs. Lalitha Chandrasekhar (right), wife of the late Indian- American Nobel Laureate Subrahmanyan Chandrasekhar, addresses the media and other invited guests in the TRW Media Hospitality Tent at the NASA Press Site at KSC as Dr. Alan Bunner, Science Program Director, Structure and Evolution of the Universe, Office of Space Science, NASA Headquarters, Washington, D.C., looks on. The name 'Chandra,' a shortened version of her husband's name which he preferred among friends and colleagues, was chosen in a contest to rename the Advanced X-ray Astrophysics Facility. 'Chandra' also means 'Moon' or 'luminous' in Sanskrit. The observatory is scheduled to be launched aboard Columbia on Space Shuttle mission STS-93.

Investigating the effects of an oral fructose challenge on hepatic ATP reserves in healthy volunteers: A (31)P MRS study.

PubMed

Bawden, S J; Stephenson, M C; Ciampi, E; Hunter, K; Marciani, L; Macdonald, I A; Aithal, G P; Morris, P G; Gowland, P A

2016-06-01

Impaired homeostasis of hepatic ATP has been associated with NAFLD. An intravenous fructose infusion has been shown to be an effective challenge to monitor the depletion and subsequent recovery of hepatic ATP reserves using (31)P MRS. The purpose of this study was to evaluate the effects of an oral rather than intravenous fructose challenge on hepatic ATP reserves in healthy subjects. Self-reported healthy males were recruited. Following an overnight fast, baseline liver glycogen and lipid levels were measured using Magnetic Resonance Spectroscopy (MRS). Immediately after consuming a 500 ml 75 g fructose drink (1275 kJ) subjects were scanned continuously for 90 min to acquire dynamic (31)P MRS measurements of liver ATP reserves. A significant effect on ATP reserves was observed across the time course (P < 0.05). Mean ATP levels reached a minimum at 50 min which was markedly lower than baseline (80 ± 17% baseline, P < 0.05). Subsequently, mean values tended to rise but did not reach statistical significance above minimum. The time to minimum ATP levels across subjects was negatively correlated with BMI (R(2) = 0.74, P < 0.005). Rates of ATP recovery were not significantly correlated with BMI or liver fat levels, but were negatively correlated with baseline glycogen levels (R(2) = 0.7, P < 0.05). Depletion of ATP reserves can be measured non-invasively following an oral fructose challenge using (31)P MRS. BMI is the best predictor of postprandial ATP homeostasis following fructose consumption. Copyright © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

1. Historic American Buildings Survey E. W. Russell, Photographer, August ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey E. W. Russell, Photographer, August 23, 1936 FRONT ELEVATION, MRS. ALBERT QUIGLEY - 751 GOVERNMENT STREET - Gilmore-Gaines-Quigley House, 751 Government Street, Mobile, Mobile County, AL

Intracellular Redox State Revealed by In Vivo 31P MRS Measurement of NAD+ and NADH Contents in Brains

PubMed Central

Lu, Ming; Zhu, Xiao-Hong; Zhang, Yi; Chen, Wei

2015-01-01

Purpose Nicotinamide adenine dinucleotide (NAD), in oxidized (NAD+) or reduced (NADH) form, plays key roles in cellular metabolism. Intracellular NAD+/NADH ratio represents the cellular redox state; however, it is difficult to measure in vivo. We report here a novel in vivo 31P MRS method for noninvasive measurement of intracellular NAD concentrations and NAD+/NADH ratio in the brain. Methods It uses a theoretical model to describe the NAD spectral patterns at a given field for quantification. Standard NAD solutions and independent cat brain measurements at 9.4 T and 16.4 T were used to evaluate this method. We also measured T1 values of brain NAD. Results Model simulation and studies of solutions and brains indicate that the proposed method can quantify submillimolar NAD concentrations with reasonable accuracy if adequate 31P MRS signal-to-noise ratio and linewidth were obtained. The NAD concentrations and NAD+/NADH ratio of cat brains measured at 16.4 T and 9.4 T were consistent despite the significantly different T1 values and NAD spectra patterns at two fields. Conclusion This newly established 31P MRS method makes it possible for the first time to noninvasively study the intracellular redox state and its roles in brain functions and diseases, and it can potentially be applied to other organs. PMID:23843330

31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients.

PubMed

Reyngoudt, Harmen; Paemeleire, Koen; Descamps, Benedicte; De Deene, Yves; Achten, Eric

2011-09-01

Differences in brain energy metabolism have been found between migraine patients and controls in previous phosphorus magnetic resonance spectroscopy ((31)P-MRS) studies, most of them emphasizing migraine with aura (MwA). The aim of this study was to verify potential changes in resting-state brain energy metabolism in patients with migraine without aura (MwoA) compared to control subjects by (31)P-MRS at 3 tesla. Quantification was performed using the phantom replacement technique. MRS measurements were performed interictally and in the medial occipital lobe of 19 MwoA patients and 26 age-matched controls. A significantly decreased phosphocreatine concentration ([PCr]) was found as in previous studies. While adenosine triphosphate concentration ([ATP]) was considered to be constant in previously published work, this study found a significant decrease in the measured [ATP] in MwoA patients. The inorganic phosphate ([P(i)]) and magnesium ([Mg(2+)]) concentrations were not significantly different between MwoA patients and controls. The altered metabolic concentrations indicate that the energy metabolism in MwoA patients is impaired, certainly in a subgroup of patients. The actual decrease in [ATP] adds further strength to the theory of the presence of a mitochondrial component in the pathophysiology of migraine.

75 FR 3901 - Announcement of IS-GPS-200E Interface Control Working Group (ICWG) Teleconference Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-25

... will be hosting an Interface Control Working Group (ICWG) teleconference meeting for the document IS... DEPARTMENT OF DEFENSE Department of the Air Force Announcement of IS-GPS-200E Interface Control Working Group (ICWG) Teleconference Meeting AGENCY: Department of the Air Force, DoD. ACTION...

JANNAF 30th Propellant Development and Characterization Subcommittee Meeting. Volume I

NASA Technical Reports Server (NTRS)

Moore, T. L. (Editor); Becker, D. L. (Editor)

2002-01-01

This volume, the first of three volumes, is a compilation of 22 unclassified/unlimited technical papers presented at the Joint Army-Navy-NASA-Air Force (JANNAF) 30th Propellant Development & Characterization Subcommittee Meeting, held on 18-21 March 2002 at the Sheraton Colorado Springs Hotel, Colorado Springs, Colorado. The papers presented herein reflect work performed in the areas of green energetic materials (GEM) development; liquid and gel propellant development; propellant surveillance and aging; and propellant chemistry test methods.

Brain GABA levels across psychiatric disorders: A systematic literature review and meta-analysis of (1) H-MRS studies.

PubMed

Schür, Remmelt R; Draisma, Luc W R; Wijnen, Jannie P; Boks, Marco P; Koevoets, Martijn G J C; Joëls, Marian; Klomp, Dennis W; Kahn, René S; Vinkers, Christiaan H

2016-09-01

The inhibitory gamma-aminobutyric acid (GABA) system is involved in the etiology of most psychiatric disorders, including schizophrenia, autism spectrum disorder (ASD) and major depressive disorder (MDD). It is therefore not surprising that proton magnetic resonance spectroscopy ((1) H-MRS) is increasingly used to investigate in vivo brain GABA levels. However, integration of the evidence for altered in vivo GABA levels across psychiatric disorders is lacking. We therefore systematically searched the clinical (1) H-MRS literature and performed a meta-analysis. A total of 40 studies (N = 1,591) in seven different psychiatric disorders were included in the meta-analysis: MDD (N = 437), schizophrenia (N = 517), ASD (N = 150), bipolar disorder (N = 129), panic disorder (N = 81), posttraumatic stress disorder (PTSD) (N = 104), and attention deficit/hyperactivity disorder (ADHD) (N = 173). Brain GABA levels were lower in ASD (standardized mean difference [SMD] = -0.74, P = 0.001) and in depressed MDD patients (SMD = -0.52, P = 0.005), but not in remitted MDD patients (SMD = -0.24, P = 0.310) compared with controls. In schizophrenia this finding did not reach statistical significance (SMD = -0.23, P = 0.089). No significant differences in GABA levels were found in bipolar disorder, panic disorder, PTSD, and ADHD compared with controls. In conclusion, this meta-analysis provided evidence for lower brain GABA levels in ASD and in depressed (but not remitted) MDD patients compared with healthy controls. Findings in schizophrenia were more equivocal. Even though future (1) H-MRS studies could greatly benefit from a longitudinal design and consensus on the preferred analytical approach, it is apparent that (1) H-MRS studies have great potential in advancing our understanding of the role of the GABA system in the pathogenesis of psychiatric disorders. Hum Brain Mapp 37:3337-3352, 2016. © 2016 Wiley Periodicals

78 FR 1881 - Notice of Public Meeting; Wyoming Resource Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-09

... Wyoming. Planned agenda topics include a tour of the Rock Springs Wild Horse Holding Facility, a... the Wild Horse Holding Facility on Lionkol Road. Following the tour, the group will meet at the High...

Evaluation of acoustic doppler velocity meters to quantify flow from Comal Springs and San Marcos Springs, Texas

USGS Publications Warehouse

Gary, Marcus O.; Gary, Robin H.; Asquith, William H.

2008-01-01

Comal Springs and San Marcos Springs are the two largest springs in Texas, are major discharge points for the San Antonio segment of the Edwards aquifer, and provide habitat for several Federally listed endangered species that depend on adequate springflows for survival. It is therefore imperative that the Edwards Aquifer Authority have accurate and timely springflow data to guide resource management. Discharge points for Comal Springs and San Marcos Springs are submerged in Landa Lake and in Spring Lake, respectively. Flows from the springs currently (2008) are estimated by the U.S Geological Survey in real time as surface-water discharge from conventional stage-discharge ratings at sites downstream from each spring. Recent technological advances and availability of acoustic Doppler velocity meters (ADVMs) now provide tools to collect data (stream velocity) related to springflow that could increase accuracy of real-time estimates of the springflows. The U.S. Geological Survey, in cooperation with the Edwards Aquifer Authority, did a study during May 2006 through September 2007 to evaluate ADVMs to quantify flow from Comal and San Marcos Springs. The evaluation was based on two monitoring approaches: (1) placement of ADVMs in important spring orifices - spring run 3 and spring 7 at Comal Springs, and diversion spring at San Marcos Springs; and (2) placement of ADVMs at the nearest flowing streams - Comal River new and old channels for Comal Springs, Spring Lake west and east outflow channels and current (2008) San Marcos River streamflow-gaging site for San Marcos Springs. For Comal Springs, ADVM application at spring run 3 and spring 7 was intended to indicate whether the flows of spring run 3 and spring 7 can be related to total springflow. The findings indicate that velocity data from both discharge features, while reflecting changes in flow, do not reliably show a direct relation to measured streamflow and thus to total Comal Springs flow. ADVMs at the Comal

The effect of epileptic seizures on proton MRS visible neurochemical concentrations.

PubMed

Simister, Robert J; McLean, Mary A; Salmenpera, Tuuli M; Barker, Gareth J; Duncan, John S

2008-09-01

To investigate post-ictal changes in cerebral metabolites. We performed a longitudinal quantitative proton magnetic resonance spectroscopy (MRS) study in 10 patients with epilepsy and 10 control subjects. The patients were studied on two occasions: immediately following a seizure, and on a second occasion at least 7h after the most recent seizure. Each study measured N-acetyl aspartate plus N-acetyl aspartyl glutamate (NAAt), Creatine plus phosphocreatine (Cr), Choline containing compounds (Cho) and glutamate plus glutamine (GLX) concentrations using a short-echo time sequence (TE=30ms), and NAAt, Cr and lactate using a second sequence with longer echo time (TE=144ms). The control group was studied on two occasions using the same sequences. No inter-scan differences were observed for the control group. NAAt and NAAt/Cr levels were lower in the patient group at both measured TEs but did not change significantly between studies. The ratio of Cr at TE 144ms to TE 30ms (Cr(144)/Cr(30)) and GLX/Cr were higher and Cho lower in the post-ictal scan compared to the inter-ictal study. Change in Cr(144)/Cr(30) and NAAt(144)/Cr(144) correlated with the post-ictal interval. Lactate measurement at longer TE was not informative. Proton MRS is sensitive to metabolite changes following epileptic seizures within the immediate post-ictal period. The ratio Cr(144)/Cr(30) is the most sensitive measure of metabolic disturbance and is highest in the post-ictal period but appears to normalise within 2h of the most recent seizure.

The source, discharge, and chemical characteristics of water from Agua Caliente Spring, Palm Springs, California

USGS Publications Warehouse

Brandt, Justin; Catchings, Rufus D.; Christensen, Allen H.; Flint, Alan L.; Gandhok, Gini; Goldman, Mark R.; Halford, Keith J.; Langenheim, V.E.; Martin, Peter; Rymer, Michael J.; Schroeder, Roy A.; Smith, Gregory A.; Sneed, Michelle; Martin, Peter

2011-01-01

Agua Caliente Spring, in downtown Palm Springs, California, has been used for recreation and medicinal therapy for hundreds of years and currently (2008) is the source of hot water for the Spa Resort owned by the Agua Caliente Band of the Cahuilla Indians. The Agua Caliente Spring is located about 1,500 feet east of the eastern front of the San Jacinto Mountains on the southeast-sloping alluvial plain of the Coachella Valley. The objectives of this study were to (1) define the geologic structure associated with the Agua Caliente Spring; (2) define the source(s), and possibly the age(s), of water discharged by the spring; (3) ascertain the seasonal and longer-term variability of the natural discharge, water temperature, and chemical characteristics of the spring water; (4) evaluate whether water-level declines in the regional aquifer will influence the temperature of the spring discharge; and, (5) estimate the quantity of spring water that leaks out of the water-collector tank at the spring orifice.

Investigation of membrane mechanics using spring networks: application to red-blood-cell modelling.

PubMed

Chen, Mingzhu; Boyle, Fergal J

2014-10-01

In recent years a number of red-blood-cell (RBC) models have been proposed using spring networks to represent the RBC membrane. Some results predicted by these models agree well with experimental measurements. However, the suitability of these membrane models has been questioned. The RBC membrane, like a continuum membrane, is mechanically isotropic throughout its surface, but the mechanical properties of a spring network vary on the network surface and change with deformation. In this work spring-network mechanics are investigated in large deformation for the first time via an assessment of the effect of network parameters, i.e. network mesh, spring type and surface constraint. It is found that a spring network is conditionally equivalent to a continuum membrane. In addition, spring networks are employed for RBC modelling to replicate the optical tweezers test. It is found that a spring network is sufficient for modelling the RBC membrane but strain-hardening springs are required. Moreover, the deformation profile of a spring network is presented for the first time via the degree of shear. It is found that spring-network deformation approaches continuous as the mesh density increases. Copyright © 2014 Elsevier B.V. All rights reserved.

Spring plant phenology and false springs in the conterminous US during the 21st century

USGS Publications Warehouse

Allstadt, Andrew J.; Vavrus, Stephen J.; Heglund, Patricia J.; Pidgeon, Anna M.; Thogmartin, Wayne E.; Radeloff, Volker C.

2015-01-01

The onset of spring plant growth has shifted earlier in the year over the past several decades due to rising global temperatures. Earlier spring onset may cause phenological mismatches between the availability of plant resources and dependent animals, and potentially lead to more false springs, when subsequent freezing temperatures damage new plant growth. We used the extended spring indices to project changes in spring onset, defined by leaf out and by first bloom, and predicted false springs until 2100 in the conterminous United States (US) using statistically-downscaled climate projections from the Coupled Model Intercomparison Project 5 ensemble. Averaged over our study region, the median shift in spring onset was 23 days earlier in the Representative Concentration Pathway 8.5 scenario with particularly large shifts in the Western US and the Great Plains. Spatial variation in phenology was due to the influence of short-term temperature changes around the time of spring onset versus season long accumulation of warm temperatures. False spring risk increased in the Great Plains and portions of the Midwest, but remained constant or decreased elsewhere. We conclude that global climate change may have complex and spatially variable effects on spring onset and false springs, making local predictions of change difficult.

Thermal Springs and the Search for Past Life on Mars

NASA Technical Reports Server (NTRS)

DesMarais, D. J.; Farmer, J. D.; Walter, M. R.

1995-01-01

Ancient thermal spring sites have several features which make them significant targets in a search for past life. Chemical (including redox) reactions in hydrothermal systems possibly played a role in the origin of life on Earth and elsewhere. Spring waters frequently contain reduced species (sulfur compounds, Fe(sup +2), etc.) which can provide chemical energy for organic synthesis. Relatively cool hydrothermal systems can sustain abundant microbial life (on Earth, at temperatures greater than 110 C). A spring site on Mars perhaps might even have maintained liquid water for periods sufficiently long to sustain surface-dwelling biota had they existed. On Earth, a variety of microbial mat communities can be sampled along the wide range of temperatures surrounding the spring, thus offering an opportunity to sample a broad biological diversity. Thermal spring waters frequently deposit minerals (carbonates, silica, etc.) which can entomb and preserve both fluid inclusions and microbial communities. These deposits can be highly fossiliferous and preserve biological inclusions for geologically long periods of time. Such deposits can cover several square km on Earth, and their distinctive mineralogy (e.g., silica- and/or carbonate-rich) can contrast sharply with that of the surrounding region. As with Martian volcanoes, Martian thermal spring complexes and their deposits might typically be much larger than their counterparts on Earth. Thus Martian spring deposits are perhaps readily detectable and even accessible. Elysium Planitia is an example of a promising region where hydrothermal activity very likely remobilized ground ice and sustained springs.

Fluorine (19F) MRS and MRI in biomedicine.

PubMed

Ruiz-Cabello, Jesús; Barnett, Brad P; Bottomley, Paul A; Bulte, Jeff W M

2011-02-01

Shortly after the introduction of (1)H MRI, fluorinated molecules were tested as MR-detectable tracers or contrast agents. Many fluorinated compounds, which are nontoxic and chemically inert, are now being used in a broad range of biomedical applications, including anesthetics, chemotherapeutic agents, and molecules with high oxygen solubility for respiration and blood substitution. These compounds can be monitored by fluorine ((19)F) MRI and/or MRS, providing a noninvasive means to interrogate associated functions in biological systems. As a result of the lack of endogenous fluorine in living organisms, (19)F MRI of 'hotspots' of targeted fluorinated contrast agents has recently opened up new research avenues in molecular and cellular imaging. This includes the specific targeting and imaging of cellular surface epitopes, as well as MRI cell tracking of endogenous macrophages, injected immune cells and stem cell transplants. Copyright © 2010 John Wiley & Sons, Ltd.

14 CFR Appendix D to Part 23 - Wheel Spin-Up and Spring-Back Loads

Code of Federal Regulations, 2014 CFR

2014-01-01

... (0.80 may be used); F Vmax=maximum vertical force on wheel (pounds)=n j W e, where W e and n j are... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Wheel Spin-Up and Spring-Back Loads D.... D Appendix D to Part 23—Wheel Spin-Up and Spring-Back Loads D23.1 Wheel spin-up loads. (a) The...

14 CFR Appendix D to Part 23 - Wheel Spin-Up and Spring-Back Loads

Code of Federal Regulations, 2013 CFR

2013-01-01

... (0.80 may be used); F Vmax=maximum vertical force on wheel (pounds)=n j W e, where W e and n j are... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Wheel Spin-Up and Spring-Back Loads D.... D Appendix D to Part 23—Wheel Spin-Up and Spring-Back Loads D23.1 Wheel spin-up loads. (a) The...

14 CFR Appendix D to Part 23 - Wheel Spin-Up and Spring-Back Loads

Code of Federal Regulations, 2011 CFR

2011-01-01

... (0.80 may be used); F Vmax=maximum vertical force on wheel (pounds)=n j W e, where W e and n j are... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Wheel Spin-Up and Spring-Back Loads D.... D Appendix D to Part 23—Wheel Spin-Up and Spring-Back Loads D23.1 Wheel spin-up loads. (a) The...

14 CFR Appendix D to Part 23 - Wheel Spin-Up and Spring-Back Loads

Code of Federal Regulations, 2010 CFR

2010-01-01

... (0.80 may be used); F Vmax=maximum vertical force on wheel (pounds)=n j W e, where W e and n j are... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Wheel Spin-Up and Spring-Back Loads D.... D Appendix D to Part 23—Wheel Spin-Up and Spring-Back Loads D23.1 Wheel spin-up loads. (a) The...

14 CFR Appendix D to Part 23 - Wheel Spin-Up and Spring-Back Loads

Code of Federal Regulations, 2012 CFR

2012-01-01

... (0.80 may be used); F Vmax=maximum vertical force on wheel (pounds)=n j W e, where W e and n j are... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Wheel Spin-Up and Spring-Back Loads D.... D Appendix D to Part 23—Wheel Spin-Up and Spring-Back Loads D23.1 Wheel spin-up loads. (a) The...

Implications of limiting mechanical thrombectomy to patients with emergent large vessel occlusion meeting top tier evidence criteria.

PubMed

Bhole, Rohini; Goyal, Nitin; Nearing, Katherine; Belayev, Andrey; Doss, Vinodh T; Elijovich, Lucas; Hoit, Daniel A; Tsivgoulis, Georgios; Alexandrov, Andrei V; Arthur, Adam S; Alexandrov, Anne W

2017-03-01

Recent guidelines for endovascular management of emergent large vessel occlusion (ELVO) award top tier evidence to the same selective criteria in recent trials. We aimed to understand how guideline adherence would have impacted treatment numbers and outcomes in a cohort of patients from a comprehensive stroke center. A retrospective observational study was conducted using consecutive emergent endovascular patients. Mechanical thrombectomy (MT) was performed with stent retrievers or large bore clot aspiration catheters. Procedural outcomes were compared between patients meeting, and those failing to meet, top tier evidence criteria. 126 patients receiving MT from January 2012 to June 2015 were included (age 31-89 years, National Institutes of Health Stroke Scale (NIHSS) score 2-38); 62 (49%) patients would have been excluded if top tier criteria were upheld: pretreatment NIHSS score <6 (10%), Alberta Stroke Program Early CT score <6 (6.5%), premorbid modified Rankin Scale (mRS) score ≥2 (27%), M2 occlusion (10%), posterior circulation (32%), symptom to groin puncture >360 min (58%). 26 (42%) subjects had more than one top tier exclusion. Symptomatic intracerebral hemorrhage (sICH) and systemic hemorrhage rates were similar between the groups. 3 month mortality was 45% in those lacking top tier evidence compared with 26% (p=0.044), and 3 month mRS score 0-2 was 33% versus 46%, respectively (NS). After adjusting for potential confounders, top tier treatment was not associated with neurological improvement during hospitalization (β -8.2; 95% CI -24.6 to -8.2; p=0.321), 3 month mortality (OR=0.38; 95% CI 0.08 to 1.41), or 3 month favorable mRS (OR=0.97; 95% CI 0.28 to 3.35). Our study showed that with strict adherence to top tier evidence criteria, half of patients may not be considered for MT. Our data indicate no increased risk of sICH and a potentially higher mortality that is largely due to treatment of patients with basilar occlusions and those treated at

Implementing OpenMRS for patient monitoring in an HIV/AIDS care and treatment program in rural Mozambique.

PubMed

Manders, Eric-Jan; José, Eurico; Solis, Manuel; Burlison, Janeen; Nhampossa, José Leopoldo; Moon, Troy

2010-01-01

We have adopted the Open Medical Record System (OpenMRS) framework to implement an electronic patient monitoring system for an HIV care and treatment program in Mozambique. The program provides technical assistance to the Ministry of Health supporting the scale up of integrated HIV care and support services in health facilities in rural resource limited settings. The implementation is in use for adult and pediatric programs, with ongoing roll-out to cover all supported sites. We describe early experiences in adapting the system to the program needs, addressing infrastructure challenges, creating a regional support team, training data entry staff, migrating a legacy database, deployment, and current use. We find that OpenMRS offers excellent prospects for in-country development of health information systems, even in severely resource limited settings. However, it also requires considerable organizational infrastructure investment and technical capacity building to ensure continued local support.

3. Historic American Buildings Survey E. W. Russell, Photographer, August ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Historic American Buildings Survey E. W. Russell, Photographer, August 23, 1936 CLOSE- UP BRACKETS AND FRIEZE, MRS. ALBERT QUIGLEY - 751 GOVERNMENT STREET - Gilmore-Gaines-Quigley House, 751 Government Street, Mobile, Mobile County, AL

Water Treatment Technology - Springs.

ERIC Educational Resources Information Center

Ross-Harrington, Melinda; Kincaid, G. David

One of twelve water treatment technology units, this student manual on springs provides instructional materials for two competencies. (The twelve units are designed for a continuing education training course for public water supply operators.) The competencies focus on spring basin construction and spring protection. For each competency, student…

Clinical Course of Homozygous Hemoglobin Constant Spring in Pediatric Patients.

PubMed

Komvilaisak, Patcharee; Jetsrisuparb, Arunee; Fucharoen, Goonnapa; Komwilaisak, Ratana; Jirapradittha, Junya; Kiatchoosakun, Pakaphan

2018-04-17

Hemoglobin (Hb) Constant Spring is an alpha-globin gene variant due to a mutation of the stop codon resulting in the elongation of the encoded polypeptide from 141 to 172 amino acid residues. Patients with homozygous Hb Constant Spring are usually mildly anemic. We retrospectively describe clinical manifestations, diagnosis, laboratory investigations, treatment, and associated findings in pediatric patients with homozygous Hb Constant Spring followed-up at Srinagarind Hospital. Sixteen pediatric cases (5 males and 11 females) were diagnosed in utero (N=6) or postnatal (n=10). Eleven cases were diagnosed with homozygous Hb Constant Spring, 4 with homozygous Hb Constant Spring with heterozygous Hb E, and 1 with homozygous Hb Constant Spring with homozygous Hb E. Three cases were delivered preterm. Six patients had low birth weights. Clinical manifestations included fetal anemia in 6 cases, hepatomegaly in 1 case, hepatosplenomegaly in 2 cases, splenomegaly in 1 case. Twelve cases exhibited early neonatal jaundice, 9 of which required phototherapy. Six cases received red cell transfusions; 1 (3), >1 (3). After the first few months of life, almost all patients had mild microcytic hypochromic anemia and an increased reticulocyte count with a wide red cell distribution (RDW), but no longer required red cell transfusion. At 1 to 2 years of age, some patients still had mild microcytic hypochromic anemia and some had normocytic hypochromic anemia with Hb around 10 g/dL, increased reticulocyte count and wide RDW. Associated findings included hypothyroidism (2), congenital heart diseases (4), genitourinary abnormalities (3), gastrointestinal abnormalities (2), and developmental delay (1). Pediatric patients with homozygous Hb Constant Spring developed severe anemia in utero and up to the age of 2 to 3 months postnatal, requiring blood transfusions. Subsequently, their anemia was mild with no evidence of hepatosplenomegaly. Their Hb level was above 9 g/dL with hypochromic

Large springs of east Tennessee

USGS Publications Warehouse

Sun, Pao-chang P.; Criner, J.H.; Poole, J.L.

1963-01-01

Springs constitute an important source of water in east Tennessee, and many individual springs are capable of supplying the large quantities needed for municipal and industrial supplies. Most of the springs in east Tennessee issue from solution openings and fractured and faulted zones in limestone and dolomite of the Knox Group, Chickamauga Limestone, and Conasauga Group. The ability of these rocks to yield a sustained flow of water to springs is dependent on a system of interconnected openings through which water can infiltrate from the land surface and move to points of natural discharge. Ninety springs were selected for detailed study, and 84 of these are analyzed in terms of magnitude and variability of discharge. Of the 84 springs analyzed, 4 flow at an average rate of 10 to 100 cfs (cubic feet per second), 62 at an average rate of 1 to 10 cfs, and 18 at an average rate of 1 cfs or less. Of the 90 springs, 75 are variable in their discharge; that is, the ratio of their fluctuations to their average discharges exceeds 100 percent. Mathematical analysis of the flow recession curve of Mill Spring near Jefferson City shows that the hydrologic system contributing to the flow of the spring has an effective capacity of about 70 million cubic feet of water. The rate of depletion of this volume of water, in the absence of significant precipitation, averages 0.0056 cfs per day between the time when the hydrologic system is full and the time when the spring ceases to flow. From such a curve it is possible to determine at any time the residual volume of water remaining in the system and the expected rate of decrease in discharge from that time to cessation of flow. Correlation of discharge measurements of 22 springs with those of Mill Spring shows that rough approximations of discharge can be projected for springs for which few measurements are available. Seventeen of the springs analyzed in this manner show good correlation with Mill Spring: that is, their coefficients

76 FR 6616 - Farm Credit Administration Board; Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-07

... requiring assistance should make arrangements in advance. The matters to be considered at the meeting are... Unified Agenda of Federal Regulatory and Deregulatory Actions and Spring 2011 Regulatory Performance Plan... Agricultural Equipment Financing Activities C. Reports Office of Management Services Quarterly Report Dated...

Walking with springs

NASA Astrophysics Data System (ADS)

Sugar, Thomas G.; Hollander, Kevin W.; Hitt, Joseph K.

2011-04-01

Developing bionic ankles poses great challenges due to the large moment, power, and energy that are required at the ankle. Researchers have added springs in series with a motor to reduce the peak power and energy requirements of a robotic ankle. We developed a "robotic tendon" that reduces the peak power by altering the required motor speed. By changing the required speed, the spring acts as a "load variable transmission." If a simple motor/gearbox solution is used, one walking step would require 38.8J and a peak motor power of 257 W. Using an optimized robotic tendon, the energy required is 21.2 J and the peak motor power is reduced to 96.6 W. We show that adding a passive spring in parallel with the robotic tendon reduces peak loads but the power and energy increase. Adding a passive spring in series with the robotic tendon reduces the energy requirements. We have built a prosthetic ankle SPARKy, Spring Ankle with Regenerative Kinetics, that allows a user to walk forwards, backwards, ascend and descend stairs, walk up and down slopes as well as jog.

78 FR 49272 - Pediatric Advisory Committee; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-13

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001.../maryland/doubletree-by-hilton-hotel-washington-dc-silver-spring-DCASSDT/index.html . Contact Person: Walter... Equity Act (Pub. L. 108-155). On September 19, 2013, the PAC will meet to discuss Cervarix (human...

Sustainable yield of a karst aquifer system: a case study of Jinan springs in northern China

NASA Astrophysics Data System (ADS)

Kang, Fengxin; Jin, Menggui; Qin, Pinrui

2011-06-01

Based on the long-term monitoring data of rainfall, groundwater levels, groundwater abstraction, spring flow rates and groundwater quality, an assessment has been undertaken of the sustainable yield of a karst aquifer system in Shandong Province, northern China, to maintain perennial outflow of the karst springs while meeting water demands. One of the fundamental indicators for sustainable yield of groundwater is identified as maximum allowable water-level drawdown. A regional three-dimensional finite-difference numerical model has been developed to optimize the schemes associated with well fields and their locations and sustainable yields, in the Jinan spring catchment and its adjacent karst groundwater catchments, with the aim of maintaining the water level higher than the allowable lowest water level of 27.5 m above sea level. Furthermore, measures necessary to move towards sustainable use of the karst groundwater are outlined, drawing on contingency plans of water-source replacement and artificial recharge, dual water supply (based in water quality), use of the spring waters themselves, and groundwater quality protection.

Intramyocellular lipid dependence on skeletal muscle fiber type and orientation characterized by diffusion tensor imaging and 1H-MRS

NASA Astrophysics Data System (ADS)

Valaparla, Sunil K.; Gao, Feng; Abdul-Ghani, Muhammad; Clarke, Geoffrey D.

2014-03-01

When muscle fibers are aligned with the B0 field, intramyocellular lipids (IMCL), important for providing energy during physical activity, can be resolved in proton magnetic resonance spectra (1H-MRS). Various muscles of the leg differ significantly in their proportion of fibers and angular distribution. This study determined the influence of muscle fiber type and orientation on IMCL using 1H-MRS and diffusion tensor imaging (DTI). Muscle fiber orientation relative to B0 was estimated by pennation angle (PA) measurements from DTI, providing orientation-specific extramyocellular lipid (EMCL) chemical shift data that were used for subject-specific IMCL quantification. Vastus lateralis (VL), tibialis anterior (TA) and soleus (SO) muscles of 6 healthy subjects (21-40 yrs) were studied on a Siemens 3T MRI system with a flex 4-channel coil. 1H-MRS were acquired using stimulated echo acquisition mode (STEAM, TR=3s, TE=270ms). DTI was performed using single shot EPI (b=600s/mm2, 30 directions, TR=4.5s, TE=82ms, and ten×5mm slices) with center slice indexed to the MRS voxel. The average PA's measured from ROI analysis of primary eigenvectors were PA=19.46+/-5.43 for unipennate VL, 15.65+/-3.73 for multipennate SO, and 7.04+/-3.34 for bipennate TA. Chemical shift (CS) was calculated using [3cos2θ-1] dependence: 0.17+/-0.02 for VL, 0.18+/-0.01 for SO and 0.19+/-0.004 ppm for TA. IMCL-CH2 concentrations from spectral analysis were 12.77+/-6.3 for VL, 3.07+/-1.63 for SO and 0.27+/-0.08 mmol/kg ww for TA. Small PA's were measured in TA and large CS with clear separation between EMCL and IMCL peaks were observed. Larger variations in PA were measured VL and SO resulting in an increased overlap of the EMCL on IMCL peaks.

Springs of Great Britain

NASA Astrophysics Data System (ADS)

Day, J. B. W.

1996-03-01

Predictably, in a country such as Britain, with its preponderance of consolidated, sedimentary, mainly fissure-flow aquifers, there is a very large number of springs, many of which are, or have been, used for public supply. Migratory springs are a feature of the British (Ur. Cretaceous) Chalk, the most important British aquifer. The Chalk's low specific yield and high capillary moisture retention together give rise to very considerable fluctuations (more than 33 m in some areas) of the unconfined water table. Along the gentle dip slopes of the Chalk (North and South Downs of southern and southeastern England) springs may migrate laterally for several miles, giving rise to seasonal streams locally known as “bournes” or “lavants”. However, springs such as at Duncton, West Sussex, at the base of the much steeper scarp slopes of the Chalk, form point sources, the flows from which tend to be relatively steady; such springs commonly supply and are the original reason for the existence of many of the small towns and villages which nestle along the bases of the chalk scarps of Sussex and Kent. Where the Chalk forms coastal cliffs, a number of springs break out at the base of the cliff between high and low tide levels; there are major chalk coastal springs, for instance, at St. Margaret's Bay (Kent) and at Arish Mells, east of Lulworth Cove, Dorset. Such springs are not used for direct supply (their salinity is usually too high) but are indicators of the presence of local reserves of groundwater for possible future development.

MR-visible water content in human brain: a proton MRS study.

PubMed

Christiansen, P; Toft, P B; Gideon, P; Danielsen, E R; Ring, P; Henriksen, O

1994-01-01

In vivo measurement of metabolite concentrations in the human brain by means of proton-MRS contributes significantly to the clinical evaluation of patients with diseases of the brain. The fully relaxed water signal has been proposed as an internal standard for calibration of the MRS measurements. The major drawbacks are the necessity to make the assumptions that the water concentrations in the brain and that all tissue water is MR-visible. A number of in vivo measurements were carried out to estimate the concentration of MR-visible water in the brain of healthy volunteers divided into four age groups: newborn (0-23 days), adolescents (10-15 yr), adults (22-28 yr), and elderly people (60-74 yr). The examinations were carried out using a Siemens Helicon SP 63/84 MR-scanner operating at 1.5 T. Except for the newborn, four regions were studied in each subject using stimulated echo (STEAM) sequences without water suppression. In vitro measurements on a standard phantom were used for calibration. The calculated water concentrations ranged between 35.8 and 39.6 (mean 36.9) mol.[kg wet weight]-1 in the three groups, whereas it was 51.5 mol.[kg wet weight]-1 in the newborn, p < .01. The observed water concentration of neither the four regions nor of the three oldest age groups were significantly different. Comparisons between the water concentrations measured and those expected based on estimation of the content of grey and white matter in the region of interest from T1-weighted images and biochemical data published, suggest that only a small fraction (< 5%) of the tissue water may be MR-invisible.(ABSTRACT TRUNCATED AT 250 WORDS)

77 FR 15798 - Notice of Intent To Repatriate Cultural Items: The Colorado College, Colorado Springs, CO

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-16

... La Poudre, Colorado Springs, CO 80903, telephone (719) 389-6201. SUPPLEMENTARY INFORMATION: Notice is... 201, 14 E. Cache La Poudre, Colorado Springs, Colorado 80903, telephone (719) 389-6201, before April...

49 CFR 229.65 - Spring rigging.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Spring rigging. 229.65 Section 229.65....65 Spring rigging. (a) Protective construction or safety hangers shall be provided to prevent spring planks, spring seats or bolsters from dropping to track structure in event of a hanger or spring failure...

49 CFR 229.65 - Spring rigging.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Spring rigging. 229.65 Section 229.65....65 Spring rigging. (a) Protective construction or safety hangers shall be provided to prevent spring planks, spring seats or bolsters from dropping to track structure in event of a hanger or spring failure...

49 CFR 229.65 - Spring rigging.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Spring rigging. 229.65 Section 229.65....65 Spring rigging. (a) Protective construction or safety hangers shall be provided to prevent spring planks, spring seats or bolsters from dropping to track structure in event of a hanger or spring failure...

49 CFR 229.65 - Spring rigging.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Spring rigging. 229.65 Section 229.65....65 Spring rigging. (a) Protective construction or safety hangers shall be provided to prevent spring planks, spring seats or bolsters from dropping to track structure in event of a hanger or spring failure...

49 CFR 229.65 - Spring rigging.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Spring rigging. 229.65 Section 229.65....65 Spring rigging. (a) Protective construction or safety hangers shall be provided to prevent spring planks, spring seats or bolsters from dropping to track structure in event of a hanger or spring failure...

Neonatal case of classic maple syrup urine disease: usefulness of (1) H-MRS in early diagnosis.

PubMed

Sato, Takeshi; Muroya, Koji; Hanakawa, Junko; Asakura, Yumi; Aida, Noriko; Tomiyasu, Moyoko; Tajima, Go; Hasegawa, Tomonobu; Adachi, Masanori

2014-02-01

We describe a male neonate with classic maple syrup urine disease (MSUD) in metabolic crisis. On day 7 of life, he was referred to hospital because of coma and metabolic acidosis with maple syrup odor. On day 4 after admission, brain magnetic resonance imaging findings were consistent with encephalopathy due to MSUD. Proton magnetic resonance spectroscopy ((1) H-MRS) showed a large methyl resonance peak at 0.9 p.p.m. The diagnosis of MSUD was confirmed on low branched-chain α-keto acid dehydrogenase complex activity in lymphocyte. (1) H-MR spectra were obtained in 10 min, while it took at least several days to obtain the results of other diagnostic examinations. In convalescence, the peak at 0.9 p.p.m. decreased. The large methyl resonance peak at 0.9 p.p.m. in brain (1) H-MRS would be one of the earliest clues to the diagnosis of classic MSUD in the neonatal period, especially in metabolic crisis. © 2014 The Authors. Pediatrics International © 2014 Japan Pediatric Society.

Plane stress problems using hysteretic rigid body spring network models

NASA Astrophysics Data System (ADS)

Christos, Sofianos D.; Vlasis, Koumousis K.

2017-10-01

In this work, a discrete numerical scheme is presented capable of modeling the hysteretic behavior of 2D structures. Rigid Body Spring Network (RBSN) models that were first proposed by Kawai (Nucl Eng Des 48(1):29-207, 1978) are extended to account for hysteretic elastoplastic behavior. Discretization is based on Voronoi tessellation, as proposed specifically for RBSN models to ensure uniformity. As a result, the structure is discretized into convex polygons that form the discrete rigid bodies of the model. These are connected with three zero length, i.e., single-node springs in the middle of their common facets. The springs follow the smooth hysteretic Bouc-Wen model which efficiently incorporates classical plasticity with no direct reference to a yield surface. Numerical results for both static and dynamic loadings are presented, which validate the proposed simplified spring-mass formulation. In addition, they verify the model's applicability on determining primarily the displacement field and plastic zones compared to the standard elastoplastic finite element method.

Spheres of discharge of springs

NASA Astrophysics Data System (ADS)

Springer, Abraham E.; Stevens, Lawrence E.

2009-02-01

Although springs have been recognized as important, rare, and globally threatened ecosystems, there is as yet no consistent and comprehensive classification system or common lexicon for springs. In this paper, 12 spheres of discharge of springs are defined, sketched, displayed with photographs, and described relative to their hydrogeology of occurrence, and the microhabitats and ecosystems they support. A few of the spheres of discharge have been previously recognized and used by hydrogeologists for over 80 years, but others have only recently been defined geomorphologically. A comparison of these spheres of discharge to classification systems for wetlands, groundwater dependent ecosystems, karst hydrogeology, running waters, and other systems is provided. With a common lexicon for springs, hydrogeologists can provide more consistent guidance for springs ecosystem conservation, management, and restoration. As additional comprehensive inventories of the physical, biological, and cultural characteristics are conducted and analyzed, it will eventually be possible to associate spheres of discharge with discrete vegetation and aquatic invertebrate assemblages, and better understand the habitat requirements of rare or unique springs species. Given the elevated productivity and biodiversity of springs, and their highly threatened status, identification of geomorphic similarities among spring types is essential for conservation of these important ecosystems.

Initial investigation of glucose metabolism in mouse brain using enriched 17 O-glucose and dynamic 17 O-MRS.

PubMed

Borowiak, Robert; Reichardt, Wilfried; Kurzhunov, Dmitry; Schuch, Christian; Leupold, Jochen; Krafft, Axel Joachim; Reisert, Marco; Lange, Thomas; Fischer, Elmar; Bock, Michael

2017-08-01

In this initial work, the in vivo degradation of 17 O-labeled glucose was studied during cellular glycolysis. To monitor cellular glucose metabolism, direct 17 O-magnetic resonance spectroscopy (MRS) was used in the mouse brain at 9.4 T. Non-localized spectra were acquired with a custom-built transmit/receive (Tx/Rx) two-turn surface coil and a free induction decay (FID) sequence with a short TR of 5.4 ms. The dynamics of labeled oxygen in the anomeric 1-OH and 6-CH 2 OH groups was detected using a Hankel-Lanczos singular value decomposition (HLSVD) algorithm for water suppression. Time-resolved 17 O-MRS (temporal resolution, 42/10.5 s) was performed in 10 anesthetized (1.25% isoflurane) mice after injection of a 2.2 M solution containing 2.5 mg/g body weight of differently labeled 17 O-glucose dissolved in 0.9% physiological saline. From a pharmacokinetic model fit of the H 2 17 O concentration-time course, a mean apparent cerebral metabolic rate of 17 O-labeled glucose in mouse brain of CMR Glc  = 0.07 ± 0.02 μmol/g/min was extracted, which is of the same order of magnitude as a literature value of 0.26 ± 0.06 μmol/g/min reported by 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET). In addition, we studied the chemical exchange kinetics of aqueous solutions of 17 O-labeled glucose at the C1 and C6 positions with dynamic 17 O-MRS. In conclusion, the results of the exchange and in vivo experiments demonstrate that the C6- 17 OH label in the 6-CH 2 OH group is transformed only glycolytically by the enzyme enolase into the metabolic end-product H 2 17 O, whereas C1- 17 OH ends up in water via direct hydrolysis as well as glycolysis. Therefore, dynamic 17 O-MRS of highly labeled 17 O-glucose could provide a valuable non-radioactive alternative to FDG PET in order to investigate glucose metabolism. Copyright © 2017 John Wiley & Sons, Ltd.

Diagnostic value of 3.0T (1)H MRS with choline-containing compounds ratio (∆CCC) in primary malignant hepatic tumors.

PubMed

Zhang, Li; Zhao, Xinming; Ouyang, Han; Wang, Shuang; Zhou, Chunwu

2016-08-22

The purpose of this study was to investigate the diagnostic value of 3.0-T (1)H magnetic resonance spectroscopy ((1)H MRS) in primary malignant hepatic tumors and to compare the effects of (1)H MRS on the diagnostic accuracy of liver-occupying lesions between junior and experienced radiologists. This study included 50 healthy volunteers and 40 consecutive patients (50 lesions). Informed consent was obtained from each subject. Images were obtained on clinical whole-body 3.0-T MR system. Point -Resolved Spectroscopy was used to obtain the spectroscopy image. All conventional images were reviewed blindly by junior radiologist and experienced radiologist, respectively. The choline-containing compounds peak area (CCC-A) was measured with SAGE software, and the choline-containing compound ratio (∆CCC) was calculated. The efficacy of CCC-A and ∆CCC in the diagnosis of primary malignant hepatic tumors was determined by plotting receiver operating characteristic (ROC) curves. We also compared the effects of MRS on the diagnostic accuracy of liver-occupying lesions with junior and experienced radiologist. A significant increase in mean CCC-A was observed in malignant tumors compared with benign tumors. The ROC curve showed ∆CCC had a high discriminatory ability in diagnosing primary malignant hepatic tumors with a sensitivity and specificity of 94.3 and 93.3 %, respectively. The ∆CCC area under the curve (AUC) was 0.97 that was larger than that of both junior and experienced radiologist, while the significantly statistical difference was only obtained between ∆CCC and junior radiologist (P = 0.01). (1)H MRS with ∆CCC demonstrates good efficacy in diagnosing primary malignant hepatic tumors. The technique improves the accuracy of diagnosing liver-occupying lesions, particularly for junior radiologists.

G.I. Joe Meets Barbie, Software Engineer Meets Caregiver: Males and Females in B.C.'s Public Schools and Beyond. BCTF Research Report.

ERIC Educational Resources Information Center

Schaefer, Anne C.

Following a referral from the March 2000 Annual General Meeting of the British Columbia (B.C.) Teachers' Federation, the Spring 2000 Representative Assembly passed a motion that recommended research be collected, conducted, and disseminated on the current status of students in the province. This research report identifies current information on…

Shape memory alloy resetable spring lift for pedestrian protection

NASA Astrophysics Data System (ADS)

Barnes, Brian M.; Brei, Diann E.; Luntz, Jonathan E.; Strom, Kenneth; Browne, Alan L.; Johnson, Nancy

2008-03-01

Pedestrian protection has become an increasingly important aspect of automotive safety with new regulations taking effect around the world. Because it is increasingly difficult to meet these new regulations with traditional passive approaches, active lifts are being explored that increase the "crush zone" between the hood and rigid under-hood components as a means of mitigating the consequences of an impact with a non-occupant. Active lifts, however, are technically challenging because of the simultaneously high forces, stroke and quick timing resulting in most of the current devices being single use. This paper introduces the SMArt (Shape Memory Alloy ReseTable) Spring Lift, an automatically resetable and fully reusable device, which couples conventional standard compression springs to store the energy required for a hood lift, with Shape Memory Alloys actuators to achieve both an ultra high speed release of the spring and automatic reset of the system for multiple uses. Each of the four SMArt Device subsystems, lift, release, lower and reset/dissipate, are individually described. Two identical complete prototypes were fabricated and mounted at the rear corners of the hood, incorporated within a full-scale vehicle testbed at the SMARTT (Smart Material Advanced Research and Technology Transfer) lab at University of Michigan. Full operational cycle testing of a stationary vehicle in a laboratory setting confirms the ultrafast latch release, controlled lift profile, gravity lower to reposition the hood, and spring recompression via the ratchet engine successfully rearming the device for repeat cycles. While this is only a laboratory demonstration and extensive testing and development would be required for transition to a fielded product, this study does indicate that the SMArt Lift has promise as an alternative approach to pedestrian protection.

Diffusion tensor imaging and 1H-MRS study on radiation-induced brain injury after nasopharyngeal carcinoma radiotherapy.

PubMed

Wang, H-Z; Qiu, S-J; Lv, X-F; Wang, Y-Y; Liang, Y; Xiong, W-F; Ouyang, Z-B

2012-04-01

To investigate the metabolic characteristics of the temporal lobes following radiation therapy for nasopharyngeal carcinoma using diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy ((1)H-MRS). DTI and (1)H-MRS were performed in 48 patients after radiotherapy for nasopharyngeal carcinoma and in 24 healthy, age-matched controls. All patients and controls had normal findings on conventional MRI. Apparent diffusion coefficient (ADC), fractional anisotropy (FA), three eigenvalues λ1, λ2, λ3, N-acetylaspartic acid (NAA)/choline (Cho), NAA/creatinine (Cr), and Cho/Cr were measured in both temporal lobes. Patients were divided into three groups according to time after completion of radiotherapy: group 1, less than 6 months; group 2, 6-12 months; group 3, more than 12 months. Mean values for each parameter were compared using one-way analysis of variance (ANOVA). Mean FA in group 1 was significantly lower compared to group 3 and the control group (p < 0.05). Group-wise comparisons of apparent diffusion coefficient (ADC) values among all the groups were not significantly different. Eigenvalue λ1 was significantly lower in groups 1 and 3 compared to the control group (p < 0.05). NAA/Cho and NAA/Cr were significantly lower in each group compared to the control group (p < 0.01 for both). The decrease in NAA/Cho was greatest in group 1. There were no significant between-group differences regarding Cho/Cr. A combination of DTI and (1)H-MRS can be used to detect radiation-induced brain injury, in patients treated for nasopharyngeal carcinoma. Copyright © 2011 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

Coil spring venting arrangement

DOEpatents

McCugh, R.M.

1975-10-21

A simple venting device for trapped gas pockets in hydraulic systems is inserted through a small access passages, operated remotely, and removed completely. The device comprises a small diameter, closely wound coil spring which is pushed through a guide temporarily inserted in the access passage. The guide has a central passageway which directs the coil spring radially upward into the pocket, so that, with the guide properly positioned for depth and properly oriented, the coil spring can be pushed up into the top of the pocket to vent it. By positioning a seal around the free end of the guide, the spring and guide are removed and the passage is sealed.

Battery Berry Observation Station, detail, frame structure meeting older masonry ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Battery Berry Observation Station, detail, frame structure meeting older masonry building on west side of structure; view east - Fort McKinley, Battery Berry Observation Station, North side of Wood Side Drive approximately 80 feet east of Spring Cove Lane, Great Diamond Island, Portland, Cumberland County, ME

Informing geobiology through GIS site suitability analysis: locating springs in mantle units of ophiolites

NASA Astrophysics Data System (ADS)

Bowman, A.; Cardace, D.; August, P.

2012-12-01

Springs sourced in the mantle units of ophiolites serve as windows to the deep biosphere, and thus hold promise in elucidating survival strategies of extremophiles, and may also inform discourse on the origin of life on Earth. Understanding how organisms can survive in extreme environments provides clues to how microbial life responds to gradients in pH, temperature, and oxidation-reduction potential. Spring locations associated with serpentinites have traditionally been located using a variety of field techniques. The aqueous alteration of ultramafic rocks to serpentinites is accompanied by the production of very unusual formation fluids, accessed by drilling into subsurface flow regimes or by sampling at related surface springs. The chemical properties of these springs are unique to water associated with actively serpentinizing rocks; they reflect a reducing subsurface environment reacting at low temperatures producing high pH, Ca-rich formation fluids with high dissolved hydrogen and methane. This study applies GIS site suitability analysis to locate high pH springs upwelling from Coast Range Ophiolite serpentinites in Northern California. We used available geospatial data (e.g., geologic maps, topography, fault locations, known spring locations, etc.) and ArcGIS software to predict new spring localities. Important variables in the suitability model were: (a) bedrock geology (i.e., unit boundaries and contacts for peridotite, serpentinite, possibly pyroxenite, or chromite), (b) fault locations, (c) regional data for groundwater characteristics such as pH, Ca2+, and Mg2+, and (d) slope-aspect ratio. The GIS model derived from these geological and environmental data sets predicts the latitude/longitude points for novel and known high pH springs sourced in serpentinite outcrops in California. Field work confirms the success of the model, and map output can be merged with published environmental microbiology data (e.g., occurrence of hydrogen-oxidizers) to showcase

Preliminary Optimization for Spring-Run Chinook Salmon Environmental Flows in Lassen Foothill Watersheds

NASA Astrophysics Data System (ADS)

Ta, J.; Kelsey, R.; Howard, J.; Hall, M.; Lund, J. R.; Viers, J. H.

2014-12-01

Stream flow controls physical and ecological processes in rivers that support freshwater ecosystems and biodiversity vital for services that humans depend on. This master variable has been impaired by human activities like dam operations, water diversions, and flood control infrastructure. Furthermore, increasing water scarcity due to rising water demands and droughts has further stressed these systems, calling for the need to find better ways to identify and allocate environmental flows. In this study, a linear optimization model was developed for environmental flows in river systems that have minimal or no regulation from dam operations, but still exhibit altered flow regimes due to surface water diversions and groundwater abstraction. Flow regime requirements for California Central Valley spring-run Chinook salmon (Oncorhynchus tshawytscha) life history were used as a test case to examine how alterations to the timing and magnitude of water diversions meet environmental flow objectives while minimizing impact to local water supply. The model was then applied to Mill Creek, a tributary of the Sacramento River, in northern California, and its altered flow regime that currently impacts adult spring-run Chinook spawning and migration. The resulting optimized water diversion schedule can be used to inform water management decisions that aim to maximize benefit for the environment while meeting local water demands.

River Intrusion in Karst Springs in Eogenetic Aquifers: Implications for Speleogenesis

NASA Astrophysics Data System (ADS)

Martin, J. B.; Gulley, J.; Screaton, E. J.

2008-12-01

Conceptual models of speleogenesis generally assume uni-directional transport in integrated conduit systems from discrete recharge points to discharge at karst springs. Estavelles, however, are karst springs that function intermittently as discrete recharge points when river stage rises more rapidly than local aquifer heads. As river water chemistry changes between baseflow and floods, estavelles should influence mass transport through (e.g. organic carbon, nutrients, and oxygen) and speleogenesis within karst systems. Estavelles are common in our study area in north-central Florida, particularly along the lower reaches of the Santa Fe River, where it flows across the unconfined karstic Floridan aquifer. River stage in this unconfined region can rise much faster than aquifer heads when large amounts of rain fall on the confined regions in its upper reaches. Backflooding into the estavelles during elevated river stage drives river water into the ground, causing some springs to reverse and other springs to recirculate large volumes of river water. Floodwaters originating in the confined region are highly undersaturated with respect to calcite, and thus river water transitions from slightly supersaturated to highly undersaturated with respect to calcite during flood events. As a result, conduits connected to estavelles are continuously enlarged as springs reverse or recirculate calcite-undersaturated river water. It has been suggested that currently flooded caves (i.e. karst conduits) associated with springs in Florida formed entirely underwater because speleothems, which are prevalent in flooded caves in the Yucatan and Bahamas, have not been observed by cave divers. Results of this study indicate that the absence of speleothems does not necessarily provide evidence of a continuous phreatic history for underwater caves. Instead speleothems that formed in caves while dry could have been dissolved by backflooding of estavelles with undersaturated water

77 FR 3750 - U.S. Air Force Academy Board of Visitors Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-25

... a meeting in Harmon Hall at the United States Air Force Academy in Colorado Springs, Colorado on 10... Academy Athletic Corporation Transition Plan Update; Character Update; Focus Group (Gold Bar Lieutenants...

Characterization of the hydrogeology of the sacred Gihon Spring, Jerusalem: a deteriorating urban karst spring

NASA Astrophysics Data System (ADS)

Amiel, Ronit Benami; Grodek, Tamir; Frumkin, Amos

2010-09-01

The Gihon Spring, Jerusalem, is important for the major monotheistic religions. Its hydrogeology and hydrochemistry is studied here in order to understand urbanization effects on karst groundwater resources, and promote better water management. High-resolution monitoring of the spring discharge, temperature and electrical conductivity, was performed, together with chemical and bacterial analysis. All these demonstrate a rapid response of the spring to rainfall events and human impact. A complex karst system is inferred, including conduit flow, fissure flow and diffuse flow. Electrical conductivity, Na+ and K+ values (2.0 mS/cm, 130 and 50 mg/l respectively) are very high compared to other nearby springs located at the town margins (0.6 mS/cm, 15 and <1 mg/l respectively), indicating considerable urban pollution in the Gihon area. The previously cited pulsating nature of the spring was not detected during the present high-resolution monitoring. This phenomenon may have ceased due to additional water sources from urban leakage and irrigation feeding the spring. The urbanization of the recharge catchment thus affects the spring water dramatically, both chemically and hydrologically. Appropriate measures should therefore be undertaken to protect the Gihon Spring and other karst aquifers threatened by rapid urbanization.

Proton MRS of the peritumoral brain.

PubMed

Chernov, Mikhail F; Kubo, Osami; Hayashi, Motohiro; Izawa, Masahiro; Maruyama, Takashi; Usukura, Masao; Ono, Yuko; Hori, Tomokatsu; Takakura, Kintomo

2005-02-15

Long-echo (TR: 2000 ms, TE: 136 ms) proton MRS of the cerebral tissue in the vicinity to intracranial lesion was done in 15 patients, mainly with parenchymal brain tumors. Significant decrease of N-acetylaspartate (NAA) (P<0.001) and more frequent presence of lactate (P<0.01) comparing with distant normal white matter were found in the perilesional brain tissue. The level of NAA in the perilesional brain tissue had negative associations with presence of lactate in the lesion (P<0.05), excess of lactate in the lesion compared to perilesional brain (P<0.01), grade of the perilesional edema (P<0.01) and patient's age (P<0.05). Multivariate analysis disclosed that identification of lactate in the lesion is associated with lower relative NAA content in the perilesional brain tissue, independently on the presence or absence of any other factor, including brain edema (P<0.001). In patients with lobar lesions who had at least one epileptic seizure during course of their disease the relative NAA content in the perilesional brain was significantly lower, comparing with those who were seizure-free (P<0.05). Therefore, lactate diffused from the tumor, or other metabolites secreted by lactate-producing neoplasm, should be considered as important contributors to the neuronal dysfunction in the surrounding brain. Decrease of NAA in the vicinity to intracranial lesions may reflect neuronal alteration responsible for associated epilepsy.

The People Next Door: Getting along with the Neighbors in "Yoo-Hoo Mrs. Goldberg" and "District 9"

ERIC Educational Resources Information Center

Beck, Bernard

2010-01-01

Two different perspectives on the immigrant struggles are found in a documentary about the radio and television program "The Goldbergs" and a science fiction thriller about the treatment of an immigrant alien community. "Yoo-Hoo Mrs. Goldberg" is optimistic and celebrates the achievements of an established ethnic community in America and the woman…

Research in rock deformation: Report of the Second Rock Deformation Colloquium, 1989 AGU Spring Meeting

NASA Astrophysics Data System (ADS)

Green, Harry

In response to the considerable interest expressed at the first Rock Deformation Colloquium held at the Fall 1988 AGU meeting in San Francisco, a second dinner meeting was held on Monday evening, May 8, 1989, at the Omni Hotel in Baltimore. The principal business items were a report by Steve Kirby (U.S. Geological Survey, Menlo Park, Calif.) concerning the meeting the previous day of the rock deformation steering committee and an after dinner presentation by Steve Freiman of the National Institute of Standards and Technology in Gaithersburg, Md., entitled “The Environmental Effects on Subcritical Crack Growth.” Kirby reported that a technical committee for rock deformation has been established within the Tectonophysics Section of AGU; the steering committee will attempt to establish constructive working relations with allied societies and disciplines, such as ceramics, metallurgy, materials science, structural geology, and surface science. Brian Evans of the Massachusetts Institute of Technology in Cambridge, Terry Tullis of Brown University in Providence, R.I., and Harry Green of the University of California at Davis agreed to be a subcommittee to propose a name for the technical committee, for discussion at the next steering committee meeting to be held before the 1989 Fall AGU meeting. Green also agreed to investigate the possibility of convening a special session at the Fall Meeting on the nature and mechanism of deep-focus earthquakes. (The session is Deep Slab Deformation and Faulting, T21B and T22A, organized by Harry and Ken Creager of the University of Washington, Seattle; it will be all day on Tuesday, December 5.)

49 CFR 236.822 - Switch, spring.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Switch, spring. 236.822 Section 236.822... Switch, spring. A switch equipped with a spring device which forces the points to their original position after being trailed through and holds them under spring compression. ...

49 CFR 236.822 - Switch, spring.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Switch, spring. 236.822 Section 236.822... Switch, spring. A switch equipped with a spring device which forces the points to their original position after being trailed through and holds them under spring compression. ...

49 CFR 236.822 - Switch, spring.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Switch, spring. 236.822 Section 236.822... Switch, spring. A switch equipped with a spring device which forces the points to their original position after being trailed through and holds them under spring compression. ...

49 CFR 236.822 - Switch, spring.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Switch, spring. 236.822 Section 236.822... Switch, spring. A switch equipped with a spring device which forces the points to their original position after being trailed through and holds them under spring compression. ...

49 CFR 236.822 - Switch, spring.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Switch, spring. 236.822 Section 236.822... Switch, spring. A switch equipped with a spring device which forces the points to their original position after being trailed through and holds them under spring compression. ...

Anomalously soft non-Euclidean spring

NASA Astrophysics Data System (ADS)

Levin, Ido; Sharon, Eran

In this work we study the mechanical properties of a frustrated elastic ribbon spring - the non-Euclidean minimal spring. This spring belongs to the family of non-Euclidean plates: it has no spontaneous curvature, but its lateral intrinsic geometry is described by a non-Euclidean reference metric. The reference metric of the minimal spring is hyperbolic, and can be embedded as a minimal surface. We argue that the existence of a continuous set of such isometric minimal surfaces with different extensions leads to a complete degeneracy of the bulk elastic energy of the minimal spring under elongation. This degeneracy is removed only by boundary layer effects. As a result, the mechanical properties of the minimal spring are unusual: the spring is ultra-soft with rigidity that depends on the thickness, t , as t raise 0 . 7 ex 7 7 2 lower 0 . 7 ex 2, and does not explicitly depend on the ribbon's width. These predictions are confirmed by a numerical study of a constrained spring. This work is the first to address the unusual mechanical properties of constrained non-Euclidean elastic objects. We also present a novel experimental system that is capable of constructing such objects, along with many other non-Euclidean plates.

Region 8: Colorado Springs Adequate Letter (8/17/2011)

EPA Pesticide Factsheets

This March 3, 2011 letter from EPA to Chistopher E. Urbina M.D., MPH, Colorado Department of Public Health and Environment states that EPA has found that the Colorado Springs, CO second 10 year Limited Maintenance Plan (LMP) adequate for transportation

Anomalously Soft Non-Euclidean Springs

NASA Astrophysics Data System (ADS)

Levin, Ido; Sharon, Eran

2016-01-01

In this work we study the mechanical properties of a frustrated elastic ribbon spring—the non-Euclidean minimal spring. This spring belongs to the family of non-Euclidean plates: it has no spontaneous curvature, but its lateral intrinsic geometry is described by a non-Euclidean reference metric. The reference metric of the minimal spring is hyperbolic, and can be embedded as a minimal surface. We argue that the existence of a continuous set of such isometric minimal surfaces with different extensions leads to a complete degeneracy of the bulk elastic energy of the minimal spring under elongation. This degeneracy is removed only by boundary layer effects. As a result, the mechanical properties of the minimal spring are unusual: the spring is ultrasoft with a rigidity that depends on the thickness t as t7 /2 and does not explicitly depend on the ribbon's width. Moreover, we show that as the ribbon is widened, the rigidity may even decrease. These predictions are confirmed by a numerical study of a constrained spring. This work is the first to address the unusual mechanical properties of constrained non-Euclidean elastic objects.

Fractures and stresses in Bone Spring sandstones

DOE Office of Scientific and Technical Information (OSTI.GOV)

Warpinski, N.R.; Sattler, A.R.; Lorenz, J.C.

This project was a collaboration between Sandia National Laboratories and the Harvey E. Yates Company (Heyco), Roswell, NM, conducted under the auspices of Department of Energy's Oil Recovery Technology Partnership. The project applied Sandia perspectives on the effects of natural fractures, stress, and sedimentology for the stimulation and production of low permeability gas reservoirs to low permeability oil reservoirs, such as those typified by the Bone Spring sandstones of the Delaware Basin, southeast New Mexico. This report details the results and analyses obtained in 1990 from core, logs, stress, and other data taken from three additional development wells. An overallmore » summary gives results from all five wells studied in this project in 1989--1990. Most of the results presented are believed to be new information for the Bone Spring sandstones.« less

49 CFR 230.111 - Spring rigging.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Spring rigging. 230.111 Section 230.111... Tenders Trucks, Frames and Equalizing System § 230.111 Spring rigging. (a) Arrangement of springs and equalizers. Springs and equalizers shall be arranged to ensure the proper distribution of weight to the...

49 CFR 230.111 - Spring rigging.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Spring rigging. 230.111 Section 230.111... Tenders Trucks, Frames and Equalizing System § 230.111 Spring rigging. (a) Arrangement of springs and equalizers. Springs and equalizers shall be arranged to ensure the proper distribution of weight to the...

49 CFR 230.111 - Spring rigging.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Spring rigging. 230.111 Section 230.111... Tenders Trucks, Frames and Equalizing System § 230.111 Spring rigging. (a) Arrangement of springs and equalizers. Springs and equalizers shall be arranged to ensure the proper distribution of weight to the...

49 CFR 230.111 - Spring rigging.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Spring rigging. 230.111 Section 230.111... Tenders Trucks, Frames and Equalizing System § 230.111 Spring rigging. (a) Arrangement of springs and equalizers. Springs and equalizers shall be arranged to ensure the proper distribution of weight to the...

Metabolic changes assessed by MRS accurately reflect brain function during drug-induced epilepsy in mice in contrast to fMRI-based hemodynamic readouts.

PubMed

Seuwen, Aline; Schroeter, Aileen; Grandjean, Joanes; Rudin, Markus

2015-10-15

Functional proton magnetic resonance spectroscopy (1H-MRS) enables the non-invasive assessment of neural activity by measuring signals arising from endogenous metabolites in a time resolved manner. Proof-of-principle of this approach has been demonstrated in humans and rats; yet functional 1H-MRS has not been applied in mice so far, although it would be of considerable interest given the many genetically engineered models of neurological disorders established in this species only. Mouse 1H-MRS is challenging as the high demands on spatial resolution typically result in long data acquisition times not commensurable with functional studies. Here, we propose an approach based on spectroscopic imaging in combination with the acquisition of the free induction decay to maximize signal intensity. Highly resolved metabolite maps have been recorded from mouse brain with 12 min temporal resolution. This enabled monitoring of metabolic changes following the administration of bicuculline, a GABA-A receptor antagonist. Changes in levels of metabolites involved in energy metabolism (lactate and phosphocreatine) and neurotransmitters (glutamate) were investigated in a region-dependent manner and shown to scale with the bicuculline dose. GABAergic inhibition induced spectral changes characteristic for increased neurotransmitter turnover and oxidative stress. In contrast to metabolic readouts, BOLD and CBV fMRI responses did not scale with the bicuculline dose indicative of the failure of neurovascular coupling. Nevertheless fMRI measurements supported the notion of increased oxidative stress revealed by functional MRS. Hence, the combined analysis of metabolic and hemodynamic changes in response to stimulation provides complementary insight into processes associated with neural activity. Copyright © 2015 Elsevier Inc. All rights reserved.

Executive summary: Weldon Spring Site Environmental Report for calendar year 1992. Weldon Spring Site Remedial Action Project, Weldon Spring, Missouri

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-06-01

This report has been prepared to provide information about the public safety and environmental protection programs conducted by the Weldon Spring Site Remedial Action Project. The Weldon Spring site is located in southern St. Charles County, Missouri, approximately 48 km (30 mi) west of St. Louis. The site consists of two main areas, the Weldon Spring Chemical Plant and raffinate pits and the Weldon Spring Quarry. The objectives of the Site Environmental Report are to present a summary of data from the environmental monitoring program, to characterize trends and environmental conditions at the site, and to confirm compliance with environmentalmore » and health protection standards and requirements. The report also presents the status of remedial activities and the results of monitoring these activities to assess their impacts on the public and environment. The scope of the environmental monitoring program at the Weldon Spring site has changed since it was initiated. Previously, the program focused on investigations of the extent and level of contaminants in the groundwater, surface waters, buildings, and air at the site. In 1992, the level of remedial activities required monitoring for potential impacts of those activities, particularly on surface water runoff and airborne effluents. This report includes monitoring data from routine radiological and nonradiological sampling activities. These data include estimates of dose to the public from the Weldon Spring site; estimates of effluent releases; and trends in groundwater contaminant levels. Also, applicable compliance requirements, quality assurance programs, and special studies conducted in 1992 to support environmental protection programs are reviewed.« less

Do natural spring waters in Australia and New Zealand affect health? A systematic review.

PubMed

Stanhope, Jessica; Weinstein, Philip; Cook, Angus

2018-02-01

Therapeutic use of spring waters has a recorded history dating back to at least 1550 BC and includes both bathing in and drinking such waters for their healing properties. In Australia and New Zealand the use of therapeutic spring waters is a much more recent phenomenon, becoming a source of health tourism from the late 1800s. We conducted a systematic review aimed at determining the potential health outcomes relating to exposure to Australian or New Zealand natural spring water. We found only low-level evidence of adverse health outcomes relating to this spring water exposure, including fatalities from hydrogen sulphide poisoning, drowning and primary amoebic meningoencephalitis. We found no studies that investigated the therapeutic use of these waters, compared with similar treatment with other types of water. From the broader literature, recommendations have been made, including fencing potentially harmful spring water, and having signage and media messages to highlight the potential harms from spring water exposure and how to mitigate the risks (e.g. not putting your head under water from geothermal springs). Sound research into the potential health benefits of Australian and New Zealand spring waters could provide an evidence base for the growing wellness tourism industry.

The Role of PDH Inhibition in the Development of Hypertrophy in the Hyperthyroid Rat Heart: A Combined MRI and Hyperpolarized MRS Study

PubMed Central

Atherton, Helen J.; Dodd, Michael S.; Heather, Lisa C.; Schroeder, Marie A.; Griffin, Julian L.; Radda, George K.; Clarke, Kieran; Tyler, Damian J.

2015-01-01

Background Hyperthyroidism increases heart rate, contractility and cardiac output, as well as metabolic rate. It is also accompanied by alterations in the regulation of cardiac substrate utilisation. Specifically, hyperthyroidism increases the ex vivo activity of pyruvate dehydrogenase kinase (PDK), thereby inhibiting glucose oxidation via pyruvate dehydrogenase (PDH). Cardiac hypertrophy is another effect of hyperthyroidism, with an increase in the abundance of mitochondria. Although the hypertrophy is initially beneficial, it can eventually lead to heart failure. The aim of this study was to use hyperpolarized magnetic resonance spectroscopy (MRS) to investigate the rate and regulation of in vivo pyruvate dehydrogenase (PDH) flux in the hyperthyroid heart, and to establish whether modulation of flux through PDH would alter cardiac hypertrophy. Methods & Results Hyperthyroidism was induced in 18 male Wistar rats with 7 daily intraperitoneal injections of freshly prepared triiodothyronine (T3; 0.2 mg/kg/day). In vivo PDH flux, assessed using hyperpolarized MRS, was reduced by 59% in hyperthyroid animals (0.0022 ± 0.0002 s−1 vs 0.0055 ± 0.0005 s−1, P = 0.0003) and this reduction was completely reversed by both acute and chronic delivery of the PDK inhibitor, dichloroacetic acid (DCA). Hyperpolarized [2-13C]pyruvate was also used to evaluate Krebs cycle metabolism and demonstrated a unique marker of anaplerosis, the level of which was significantly increased in the hyperthyroid heart. Cine MRI showed that chronic DCA treatment significantly reduced the hypertrophy observed in hyperthyroid animals (100 ± 20 mg vs 200 ± 30 mg; P = 0.04) despite no change to the increase observed in cardiac output. Conclusions This work has demonstrated that inhibition of glucose oxidation in the hyperthyroid heart in vivo is PDK mediated. Relieving this inhibition can increase the metabolic flexibility of the hyperthyroid heart and reduce the level of hypertrophy that develops

Small serine recombination systems ParA-MRS and CinH-RS2 perform precise excision of plastid DNA

USDA-ARS?s Scientific Manuscript database

Selectable marker genes (SMGs) are necessary for selection of transgenic plants. However, once stable transformants have been identified, the marker gene is no longer needed. In this study, we demonstrate the use of the small serine recombination systems, ParA-MRS and CinH-RS2, to precisely excise ...

Spring-mediated distraction enterogenesis in-continuity.

PubMed

Huynh, Nhan; Rouch, Joshua D; Scott, Andrew; Chiang, Elvin; Wu, Benjamin M; Shekherdimian, Shant; Dunn, James C Y

2016-12-01

Distraction enterogenesis has been investigated as a novel treatment for patients with short bowel syndrome (SBS) but has been limited by loss of intestinal length during restoration and need for multiple bowel surgeries. The feasibility of in-continuity, spring-mediated intestinal lengthening has yet to be demonstrated. Juvenile mini-Yucatan pigs underwent in-continuity placement of polycaprolactone (PCL) degradable springs within jejunum. Methods used to anchor the spring ends to the intestine included full-thickness sutures and a high-friction surface spring. Spring constant (k) was 6-15N/m. Bowel was examined for length and presence of spring at 1 to 4weeks. Animals tolerated in-continuity lengthening without bowel obstruction for up to 29days. In-continuity jejunum with springs demonstrated intestinal lengthening by 1.47-fold ±0.11. Five springs had detached prematurely, and lengthening could not be assessed. Histologically, in-continuity jejunum showed significantly increased crypt depth and muscularis thickness in comparison to normal jejunum. Self-expanding endoluminal springs placed in continuity could lengthen intestine without obstruction in a porcine model. This is the first study showing safety and efficacy of a self-expanding endoluminal device for distraction enterogenesis. This is proof-of-concept that in-continuity spring lengthening is feasible and demonstrates its therapeutic potential in SBS. Level 3. Copyright © 2016 Elsevier Inc. All rights reserved.

Metastasis Research Society VII International Congress (Part II). 7-10 October 1998, San Diego, CA, USA.

PubMed

Chambers, A F

1999-02-01

The Metastasis Research Society (MRS) has held its International Congress every two years since 1986, and alternates between European and North American meeting venues. The next MRS International Congress will be held in London, UK in the year 2000, and will be hosted by the current MRS President, Dr. Suzanne Eccles (Institute of Cancer Research, Sutton, UK). Dr. Eccles took over from the out-going President, Dr. William Stetler-Stevenson (National Institutes of Health, Bethesda, MD, USA), at the San Diego meeting. Information on joining the Metastasis Research Society, which includes a subscription to the Society's journal, Clinical and Experimental Metastasis, can be obtained from Dr. Eccles (suzan@icr.ac.uk) or from the newly-elected Secretary/Treasurer Dr. Danny Welch (Hershey, PA, USA; drw9@psu.edu). The meeting was organized by Darwin Medical Communications Ltd (Gill Heaton, Oxford, UK), who have placed the full program on the meeting web site (http:@www.sparks.co.uk/mrs). It is envisaged that full abstracts of all the presentations will be placed on the Metastasis Research Society web site, which is currently under construction. Corporate sponsors for the San Diego meeting included Agouron Pharmaceuticals, Becton Dickinson & Co, Zeneca Pharma SA, Schering AG, AntiCancer Inc, Oncogene Research Products, Daiichi Seiyaku Co Ltd and Novartis Pharma AG.

From policy to practice: strategies to meet physical activity standards in YMCA afterschool programs.

PubMed

Beets, Michael W; Weaver, Robert G; Moore, Justin B; Turner-McGrievy, Gabriel; Pate, Russell R; Webster, Collin; Beighle, Aaron

2014-03-01

In 2011, the U.S. Young Men's Christian Association (YMCA) adopted activity standards recommending that afterschool programs (ASPs) ensure all children engage in a minimum of 30 minutes of moderate to vigorous physical activity (MVPA) daily during the ASP. ASPs decide how to accomplish this standard, for which few effective strategies exist. To evaluate strategies designed to help ASPs meet the MVPA standard. Single group intervention with pretest and three follow-up measures repeated-cross-sectional design with a subsample cohort. Four large-scale YMCA ASPs, serving approximately 500 children each day. Community-based participatory development of strategies focused on modification of program schedules, professional development training, and weekly checklists to evaluate activity opportunities. Accelerometry-derived MVPA classified as meet or fail-to-meet the 30 minutes' MVPA/day standard collected over a minimum of 4 nonconsecutive days at baseline (fall 2011) and three follow-up assessments (spring 2012, fall 2012, spring 2013). Random intercept logistic regression models evaluated the probability of meeting the standard for boys and girls, separately (analyzed summer 2013). A total of 895 children (aged 5-12 years, 48.4% girls) representing 3654 daily measures were collected across the four assessments. The percentage of girls and boys meeting the MVPA standard at baseline was 13.3% and 28.0%, respectively. By spring 2013, this increased to 29.3% and 49.6%. These changes represented an increase in the odds of meeting the 30 minutes' MVPA/day standard by 1.5 (95% CI=1.1, 2.0) and 2.4 (95% CI=1.2, 4.8) for girls and boys, respectively. The strategies developed herein represent an effective approach to enhancing current practice within YMCA ASPs to achieve existing MVPA standards. Additional work is necessary to evaluate the scalability of the strategies in a larger sample of ASPs. © 2014 American Journal of Preventive Medicine Published by American Journal of

Assessment of sulfurous springs in the west of Iraq for balneotherapy, drinking, irrigation and aquaculture purposes.

PubMed

Awadh, Salih Muhammad; Al-Ghani, Sura Abdul

2014-06-01

This research deals with the sulfurous spring waters flow along the course of the Euphrates River in western Iraq in the area extended between Haqlaniya and Hit within the Al-Anbar governorate. Eleven springs (3 in Haqlanya, 4 in Kubaysa and 4 in Hit) have been addressed for the purpose of water evaluation for balneology, drinking, irrigation and aquaculture (fish farming). In order to meet the objectives of this research, all springs were sampled and analyzed for the total dissolved solid, electrical conductivity, pH, temperature, major cations (Ca(2+), Mg(2+), Na(+) and K(+)), major anions (SO(4)(2-), Cl(-), HCO(3)(-) and CO(3)(2-)), minor anions (PO(4)(3-)and NO(3)(-)) as well as the trace elements that included Pb, Zn, Cd, Ni, Fe, Mn, Cu, Br, F, Ba, B, Sr, Al, As, Cr, Hg and Se. The International Standards of World Health Organization are used for assessing the water quality. The results revealed that the springs belong to the tepid springs of 27-30 °C and classified as hypothermal to the thermal springs. Lithochemistry and geochemical processes clearly affected the water chemistry. The hydrogeochemical processes are responsible for the element enrichment in water by the chemical dissolution of carbonate and gypsum and evaporation as well. The results of the study indicate the possibility of using spring water for therapeutic purposes, but not allowed for drinking and aquaculture (fish farming), except those free of H(2)S gas. On the other hand, it can be used for irrigation with risk. However, soil type as well as proper selection of plants should be taken into consideration.

Spring/dimple instrument tube restraint

DOEpatents

DeMario, Edmund E.; Lawson, Charles N.

1993-01-01

A nuclear fuel assembly for a pressurized water nuclear reactor has a spring and dimple structure formed in a non-radioactive insert tube placed in the top of a sensor receiving instrumentation tube thimble disposed in the fuel assembly and attached at a top nozzle, a bottom nozzle, and intermediate grids. The instrumentation tube thimble is open at the top, where the sensor or its connection extends through the cooling water for coupling to a sensor signal processor. The spring and dimple insert tube is mounted within the instrumentation tube thimble and extends downwardly adjacent the top. The springs and dimples restrain the sensor and its connections against lateral displacement causing impact with the instrumentation tube thimble due to the strong axial flow of cooling water. The instrumentation tube has a stainless steel outer sleeve and a zirconium alloy inner sleeve below the insert tube adjacent the top. The insert tube is relatively non-radioactivated inconel alloy. The opposed springs and dimples are formed on diametrically opposite inner walls of the insert tube, the springs being formed as spaced axial cuts in the insert tube, with a web of the insert tube between the cuts bowed radially inwardly for forming the spring, and the dimples being formed as radially inward protrusions opposed to the springs.

Reduced myo-inositol and total choline measured with cerebral MRS in acute thyrotoxic Graves' disease.

PubMed

Elberling, T V; Danielsen, E R; Rasmussen, A K; Feldt-Rasmussen, U; Waldemar, G; Thomsen, C

2003-01-14

Neuropsychiatric symptoms in the acute thyrotoxic phase of Graves' disease suggest involvement of brain processes. Short-echo-time proton MRS was used to measure the cerebral metabolite profile in newly diagnosed and untreated Graves' disease. Sixteen patients with Graves' disease and 18 age- and sex-matched healthy volunteers were studied. The patients had significantly reduced total choline and myo-inositol in the acute phase of Graves' thyrotoxicosis compared with the healthy volunteers.

Sulfur spring dermatitis.

PubMed

Lee, Chieh-Chi; Wu, Yu-Hung

2014-11-01

Thermal sulfur baths are a form of balneotherapy promoted in many cultures for improvement of skin conditions; however, certain uncommon skin problems may occur after bathing in hot sulfur springs. We report the case of a 65-year-old man who presented with multiple confluent, punched-out, round ulcers with peripheral erythema on the thighs and shins after bathing in a hot sulfur spring. Histopathologic examination revealed homogeneous coagulation necrosis of the epidermis and papillary dermis. Tissue cultures showed no evidence of a microbial infection. The histopathologic findings and clinical course were consistent with a superficial second-degree burn. When patients present with these findings, sulfur spring dermatitis should be considered in the differential diagnosis. Moreover, the patient's clinical history is crucial for correct diagnosis.

Volusia Blue Spring - A Hydrological Treasure

USGS Publications Warehouse

German, Edward R.

2008-01-01

Springs are natural openings in the ground through which water beneath the surface discharges into hydrologic features such as lakes, rivers, or the ocean. The beautiful springs and spring rivers are among Florida's most valued natural resources; their gemlike refreshing waters have been a focal point of life from prehistoric times to the present (2008). The steady flow of freshwater at a nearly constant water temperature attracted animals now long absent from Florida's landscape. Fossil remains and human artifacts, discovered by divers from many spring runs, attest to the importance of springs to the State's earliest inhabitants. Explorers of Florida, from Ponce de Leon to John and William Bartram and others, often mentioned the springs that were scattered across central and northern Florida. As colonists and settlers began to inhabit Florida, springs continued to be the focus of human activity, becoming sites of missions, towns, and steamboat landings.

Mrs. Miniver's Girls: Plucky Girls in "Hidden Figures," "The Zookeeper's Wife," "Their Finest," and "Colossal"

ERIC Educational Resources Information Center

Beck, Bernard

2017-01-01

Four recent movies, "Hidden Figures," "The Zookeeper's Wife," "Their Finest," and "Colossal" exemplify a new cultural version of the movie heroine. This version combines feminism with commitment to solving an overwhelming problem. These heroines, thus, display the character virtues of Wonder Woman and Mrs.…

Field observations and management strategy for hot spring wastewater in Wulai area, Taiwan.

PubMed

Lin, J Y; Chen, C F; Lei, F R; Hsieh, C D

2010-01-01

Hot springs are important centers for recreation and tourism. However, the pollution that may potentially be caused by hot spring wastewater has rarely been discussed. More than half of Taiwan's hot springs are located in areas where the water quality of water bodies is to be protected, and untreated wastewater could pollute the receiving water bodies. In this study, we investigate hot spring wastewater in the Wulai area, one of Taiwan's famous hot spring resorts. Used water from five hot spring hotels was sampled and ten sampling events were carried out to evaluate the changes in the quality of used water in different seasons, at different periods of the week, and from different types of hotels. The concentrations of different pollutants in hot spring wastewater were found to exhibit wide variations, as follows: COD, 10-250 mg/L; SS, N.D.-93 mg/L; NH(3)-N, 0.01-1.93 mg/L; TP, 0.01-0.45 mg/L; and E. coli, 10-27,500 CFU/100 mL. The quality of hot spring wastewater depends on the operation of public pools, because this affects the frequency of supplementary fresh water and the outflow volume. Two management strategies, namely, onsite treatment systems and individually packaged treatment equipment, are considered, and a multi-objective optimization model is used to determine the optimal strategy.

The role of tributary mixing in chemical variations at a karst spring, Milandre, Switzerland

NASA Astrophysics Data System (ADS)

Perrin, J.; Jeannin, P.-Y.; Cornaton, F.

2007-01-01

SummarySolute concentration variations during flood events were investigated in a karst aquifer of the Swiss Jura. Observations were made at the spring, and at the three main subterraneous tributaries feeding the spring. A simple transient flow and transport numerical model was able to reproduce chemographs and hydrographs observed at the spring, as a result of a mixing of the concentration and discharge of the respective tributaries. Sensitivity analysis carried out with the model showed that it is possible to produce chemical variations at the spring even if all tributaries have constant (but different for each of them) solute concentrations. This process is called tributary mixing. The good match between observed and modelled curves indicate that, in the phreatic zone, tributary mixing is probably an important process that shapes spring chemographs. Chemical reactions and other mixing components (e.g. from low permeability volumes) have a limited influence. Dissolution-related (calcium, bicarbonate, specific conductance) and pollution-related parameters (nitrate, chloride, potassium) displayed slightly different behaviours: during moderate flood events, the former showed limited variations compared to the latter. During large flood events, both presented chemographs with significant changes. No significant event water participates in moderate flood events and tributary mixing will be the major process shaping chemographs. Variations are greater for parameters with higher spatial variability (e.g. pollution-related). Whereas for large flood events, the contribution of event water becomes significant and influences the chemographs of all the parameters. As a result, spring water vulnerability to an accidental pollution is low during moderate flood events and under base flow conditions. It strongly increases during large flood events, because event water contributes to the spring discharge.

Spring/dimple instrument tube restraint

DOEpatents

DeMario, E.E.; Lawson, C.N.

1993-11-23

A nuclear fuel assembly for a pressurized water nuclear reactor has a spring and dimple structure formed in a non-radioactive insert tube placed in the top of a sensor receiving instrumentation tube thimble disposed in the fuel assembly and attached at a top nozzle, a bottom nozzle, and intermediate grids. The instrumentation tube thimble is open at the top, where the sensor or its connection extends through the cooling water for coupling to a sensor signal processor. The spring and dimple insert tube is mounted within the instrumentation tube thimble and extends downwardly adjacent the top. The springs and dimples restrain the sensor and its connections against lateral displacement causing impact with the instrumentation tube thimble due to the strong axial flow of cooling water. The instrumentation tube has a stainless steel outer sleeve and a zirconium alloy inner sleeve below the insert tube adjacent the top. The insert tube is relatively non-radioactivated inconel alloy. The opposed springs and dimples are formed on diametrically opposite inner walls of the insert tube, the springs being formed as spaced axial cuts in the insert tube, with a web of the insert tube between the cuts bowed radially inwardly for forming the spring, and the dimples being formed as radially inward protrusions opposed to the springs. 7 figures.

Simultaneous acquisition of magnetic resonance spectroscopy (MRS) data and positron emission tomography (PET) images with a prototype MR-compatible, small animal PET imager

NASA Astrophysics Data System (ADS)

Raylman, Raymond R.; Majewski, Stan; Velan, S. Sendhil; Lemieux, Susan; Kross, Brian; Popov, Vladimir; Smith, Mark F.; Weisenberger, Andrew G.

2007-06-01

Multi-modality imaging (such as PET-CT) is rapidly becoming a valuable tool in the diagnosis of disease and in the development of new drugs. Functional images produced with PET, fused with anatomical images created by MRI, allow the correlation of form with function. Perhaps more exciting than the combination of anatomical MRI with PET, is the melding of PET with MR spectroscopy (MRS). Thus, two aspects of physiology could be combined in novel ways to produce new insights into the physiology of normal and pathological processes. Our team is developing a system to acquire MRI images and MRS spectra, and PET images contemporaneously. The prototype MR-compatible PET system consists of two opposed detector heads (appropriate in size for small animal imaging), operating in coincidence mode with an active field-of-view of ˜14 cm in diameter. Each detector consists of an array of LSO detector elements coupled through a 2-m long fiber optic light guide to a single position-sensitive photomultiplier tube. The use of light guides allows these magnetic field-sensitive elements of the PET imager to be positioned outside the strong magnetic field of our 3T MRI scanner. The PET scanner imager was integrated with a 12-cm diameter, 12-leg custom, birdcage coil. Simultaneous MRS spectra and PET images were successfully acquired from a multi-modality phantom consisting of a sphere filled with 17 brain relevant substances and a positron-emitting radionuclide. There were no significant changes in MRI or PET scanner performance when both were present in the MRI magnet bore. This successful initial test demonstrates the potential for using such a multi-modality to obtain complementary MRS and PET data.

N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI).

PubMed

Walecki, Jerzy; Barcikowska, Maria; Ćwikła, Jarosław B; Gabryelewicz, Tomasz

2011-12-01

Purpose of study was evaluation of regional metabolic disorders using 1H MRS in patients with MCI, as a predictor of clinical conversion to dementia based on clinical follow-up. The study group consisted of 31 subjects with diagnosis of MCI based on criteria the Mayo Clinic Group. ¹H MRS was performed with a single-voxel method using PRESS sequence. The volume of interest (VOI) was located in the hippocampal formation and posterior part of the cingulated gyrus. Patients had annual clinical control at least twice. At the beginning, 9 had amnestic MCI and the others had multidomain MCI. During follow-up (median 3 yrs) 8 subjects had stable disease (SD), 13 had disease progression (DP) and 10 develop Alzheimer disease (AD). Baseline metabolic ratios (1H MRS) between 3 groups indicated significant difference (P < 0.05) in left frontal lobe in mI/H20 ratio, between patients with SD (0.27) and DP. In comparing the groups with DP and AD, a significant difference in NAA/Cr (1.77 vs. 1.43) was found. A significant difference within left temporal external lobes was found between SD and DP in NAA/H2O ratio (0.55 vs. 0.51). An additional significant difference within medial temporal lobe was found between DP and AD in Glx/H2O ratio (0.44 vs. 0.34) on the right side. 1H MRS seems to be sensitive method allows prediction of which patients are liable to progress from MCI to AD. Combined with other biomarkers of disease staging, it is an important approach in the preclinical AD diagnosis, as well as the assessment of dementia progression.

Altered metabolites of the rat hippocampus after mild and moderate traumatic brain injury - a combined in vivo and in vitro 1 H-MRS study.

PubMed

Singh, Kavita; Trivedi, Richa; Verma, Ajay; D'souza, Maria M; Koundal, Sunil; Rana, Poonam; Baishya, Bikash; Khushu, Subash

2017-10-01

Traumatic brain injury (TBI) has been shown to affect hippocampus-associated learning, memory and higher cognitive functions, which may be a consequence of metabolic alterations. Hippocampus-associated disorders may vary depending on the severity of injury [mild TBI (miTBI) and moderate TBI (moTBI)] and time since injury. The underlying hippocampal metabolic irregularities may provide an insight into the pathological process following TBI. In this study, in vivo and in vitro proton magnetic resonance spectroscopy ( 1 H-MRS) data were acquired from the hippocampus region of controls and TBI groups (miTBI and moTBI) at D0 (pre-injury), 4 h, Day 1 and Day 5 post-injury (PI). In vitro MRS results indicated trauma-induced changes in both miTBI and moTBI; however, in vivo MRS showed metabolic alterations in moTBI only. miTBI and moTBI showed elevated levels of osmolytes indicating injury-induced edema. Altered levels of citric acid cycle intermediates, glutamine/glutamate and amino acid metabolism indicated injury-induced aberrant bioenergetics, excitotoxicity and oxidative stress. An overall similar pattern of pathological process was observed in both miTBI and moTBI, with the distinction of depleted N-acetylaspartate levels (indicating neuronal loss) at 4 h and Day 1 and enhanced lactate production (indicating heightened energy depletion leading to the commencement of the anaerobic pathway) at Day 5 in moTBI. To the best of our knowledge, this is the first study to investigate the hippocampus metabolic profile in miTBI and moTBI simultaneously using in vivo and in vitro MRS. Copyright © 2017 John Wiley & Sons, Ltd.

Study on dynamic relationship of spring water in Jinan spring area based on gray relational analysis

NASA Astrophysics Data System (ADS)

Zhang, Zhengxian; Liu, Yi; Zhang, Fengxian; Zhang, Leixian

2018-03-01

Springs Jinan to spring sparks spectacular and famous at home and abroad. With the development of the city and the increase of the amount of groundwater, the gas inflow of Jinan spring group in the late 1960s has been declining. In the early 1970s, Baotu Spring has dried up in the dry season. Since then, the spring water in most years has been cut off and the drying time Growing. In recent years, under the leadership of the provincial and municipal governments, through the joint efforts of various departments and in the extreme conditions of precipitation, making Jinan spring has been spewing more than 4 years. In this paper, the changes of groundwater level fluctuation in the western part of Jinan and the urban area in Jinan in 2015 are analyzed. The gray relational analysis method is used to study the fluctuation of groundwater in the west of Jinan and the spring area of Jinan City. Through the calculation of the correlation degree, it is found that the mean value of the correlation between the groundwater level of the monitoring wells and the water level of the spring water in the urban area is 0.7738. This data indicates a higher degree of correlation. Thus, the amount of groundwater in Jixi and Jinan City is illustrated by the presence of hydraulic connections. But to protect the famous spring spewing, reproduce the natural landscape of water and build a harmonious water city, this ambitious goal is still good and fast development process in Jinan, a subject.

[History of hot spring bath treatment in China].

PubMed

Hao, Wanpeng; Wang, Xiaojun; Xiang, Yinghong; Gu Li, A Man; Li, Ming; Zhang, Xin

2011-07-01

As early as the 7th century B.C. (Western Zhou Dynasty), there is a recording as 'spring which contains sulfur could treat disease' on the Wentang Stele written by WANG Bao. Wenquan Fu written by ZHANG Heng in the Easten Han Dynasty also mentioned hot spring bath treatment. The distribution of hot springs in China has been summarized by LI Daoyuan in the Northern Wei Dynasty in his Shuijingzhu which recorded hot springs in 41 places and interpreted the definition of hot spring. Bencao Shiyi (by CHEN Cangqi, Tang Dynasty) discussed the formation of and indications for hot springs. HU Zai in the Song Dynasty pointed out distinguishing hot springs according to water quality in his book Yuyin Conghua. TANG Shenwei in the Song Dynasty noted in Jingshi Zhenglei Beiji Bencao that hot spring bath treatment should be combined with diet. Shiwu Bencao (Ming Dynasty) classified hot springs into sulfur springs, arsenicum springs, cinnabar springs, aluminite springs, etc. and pointed out their individual indications. Geologists did not start the work on distribution and water quality analysis of hot springs until the first half of the 20th century. There are 972 hot springs in Wenquan Jiyao (written by geologist ZHANG Hongzhao and published in 1956). In July 1982, the First National Geothermal Conference was held and it reported that there were more than 2600 hot springs in China. Since the second half of the 20th century, hot spring sanatoriums and rehabilitation centers have been established, which promoted the development of hot spring bath treatment.

Abnormalities in Human Brain Creatine Metabolism in Gulf War Illness Probed with MRS

DTIC Science & Technology

2013-10-01

spectra under these conditions (see Figure 1 below). 4_1, TR = 2 s, NSA = 320, duration = 10:48, rms B1 = 2.35 μT 7 5_1, TR = 3s, NSA ...216, duration = 10:57, rms B1 = 1.92 μT 6_1, TR = 2 s, NSA = 320, duration = 10:48, rms B1 = 2.35 μT Figure 1. 08/09/13 3T6594 31P ISIS MRS...coil (after repair). TR = 4 s and NSA = 144, duration = 9:44, TE = min (0.10 ms), 2 disdacqs, SW = 3000 Hz, 2048 data points zero-filled to 4096

Cooking up an open source EMR for developing countries: OpenMRS - a recipe for successful collaboration.

PubMed

Mamlin, Burke W; Biondich, Paul G; Wolfe, Ben A; Fraser, Hamish; Jazayeri, Darius; Allen, Christian; Miranda, Justin; Tierney, William M

2006-01-01

Millions of people are continue to die each year from HIV/AIDS. The majority of infected persons (>95%) live in the developing world. A worthy response to this pandemic will require coordinated, scalable, and flexible information systems. We describe the OpenMRS system, an open source, collaborative effort that can serve as a foundation for EMR development in developing countries. We report our progress to date, lessons learned, and future directions.

Activation induced changes in GABA: Functional MRS at 7T with MEGA-sLASER.

PubMed

Chen, Chen; Sigurdsson, Hilmar P; Pépés, Sophia E; Auer, Dorothee P; Morris, Peter G; Morgan, Paul S; Gowland, Penny A; Jackson, Stephen R

2017-08-01

Functional magnetic resonance spectroscopy (fMRS) has been used to assess the dynamic metabolic responses of the brain to a physiological stimulus non-invasively. However, only limited information on the dynamic functional response of γ-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain, is available. We aimed to measure the activation-induced changes in GABA unambiguously using a spectral editing method, instead of the conventional direct detection techniques used in previous fMRS studies. The Mescher-Garwood-semi-localised by adiabatic selective refocusing (MEGA-sLASER) sequence was developed at 7T to obtain the time course of GABA concentration without macromolecular contamination. A significant decrease (-12±5%) in the GABA to total creatine ratio (GABA/tCr) was observed in the motor cortex during a period of 10min of hand-clenching, compared to an initial baseline level (GABA/tCr =0.11±0.02) at rest. An increase in the Glx (glutamate and glutamine) to tCr ratio was also found, which is in agreement with previous findings. In contrast, no significant changes in NAA/tCr and tCr were detected. With consistent and highly efficient editing performance for GABA detection and the advantage of visually identifying GABA resonances in the spectra, MEGA-sLASER is demonstrated to be an effective method for studying of dynamic changes in GABA at 7T. Copyright © 2017 Elsevier Inc. All rights reserved.

76 FR 82310 - Cardiovascular and Renal Drugs Advisory Committee; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-30

... (Parkinson's Disease, Multiple System Atrophy, and Pure Autonomic Failure), Dopamine Beta-Hydroxylase... recommendations to the Agency on FDA's regulatory issues. Date and Time: The meeting will be held on February 23... Colesville Rd., Silver Spring, MD 20910. The hotel's telephone number is (301) 589-5200. Contact Person...

Comparison of the microflora on organically and conventionally grown spring mix from a California processor.

PubMed

Phillips, Christie A; Harrison, Mark A

2005-06-01

Considerable speculation has occurred concerning the potential for higher numbers of foodborne pathogens on organically grown produce compared with produce not grown organically. The microflora composition of spring mix or mesclun, a mixture of multiple salad ingredients, grown either by organic or conventional means was determined. Unwashed or washed spring mix was obtained from a commercial California fresh-cut produce processor who does not use manure in their cultivation practices. Fifty-four samples of each type of product were supplied over a 4-month period. Analysis included enumeration of total mesophiles, psychrotrophs, coliforms, generic Escherichia coli, lactic acid bacteria, yeasts, and molds. In addition, spring mix was analyzed for the presence of Salmonella and Listeria monocytogenes. The mean populations of mesophilic and psychrotrophic bacteria, yeasts, molds, lactic acid bacteria, and coliforms on conventionally grown spring mix were not statistically different (P > 0.05) from respective mean populations on organically grown spring mix. The mean population of each microbial group was significantly higher on unwashed spring mix compared with the washed product. Of the 14 samples found to contain E. coli, eight were from nonwashed conventional spring mix, one was from washed conventional spring mix, and four were from nonwashed organic spring mix. Salmonella and L. monocytogenes were not detected in any of the samples analyzed.

78 FR 60863 - Threat Reduction Advisory Committee; Notice of Federal Advisory Committee Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

... DEPARTMENT OF DEFENSE Office of the Secretary Threat Reduction Advisory Committee; Notice of... Defense announces the following Federal advisory committee meeting of the Threat Reduction Advisory... Springs, CO. FOR FURTHER INFORMATION CONTACT: Mr. William Hostyn, DoD, Defense Threat Reduction Agency/J2...

Running springs: speed and animal size.

PubMed

Farley, C T; Glasheen, J; McMahon, T A

1993-12-01

Trotting and hopping animals use muscles, tendons and ligaments to store and return elastic energy as they bounce along the ground. We examine how the musculoskeletal spring system operates at different speeds and in animals of different sizes. We model trotting and hopping as a simple spring-mass system which consists of a leg spring and a mass. We find that the stiffness of the leg spring (k(leg)) is nearly independent of speed in dogs, goats, horses and red kangaroos. As these animals trot or hop faster, the leg spring sweeps a greater angle during the stance phase, and the vertical excursion of the center of mass during the ground contact phase decreases. The combination of these changes to the spring system causes animals to bounce off the ground more quickly at higher speeds. Analysis of a wide size range of animals (0.1-140 kg) at equivalent speeds reveals that larger animals have stiffer leg springs (k(leg) [symbol: see text] M0.67, where M is body mass), but that the angle swept by the leg spring is nearly independent of body mass. As a result, the resonant period of vertical vibration of the spring-mass system is longer in larger animals. The length of time that the feet are in contact with the ground increases with body mass in nearly the same way as the resonant period of vertical vibration.

Water-quality characteristics and contaminants in the rural karst-dominated Spring Mill Lake watershed, southern Indiana

USGS Publications Warehouse

Hasenmueller, N.R.; Buehler, M.A.; Krothe, N.C.; Comer, J.B.; Branam, T.D.; Ennis, M.V.; Smith, R.T.; Zamani, D.D.; Hahn, L.; Rybarczyk, J.P.

2006-01-01

The Spring Mill Lake watershed is located in the Mitchell Plateau, a karst area that developed on Mississippian carbonates in southern Indiana. Spring Mill Lake is a reservoir built in the late 1930s and is located in Spring Mill State Park. Within the park, groundwater from subsurface conduits issues as natural springs and then flows in surface streams to the lake. From 1998 to 2002, surface and subsurface hydrology and water quality were investigated to determine the types and sources of potential contaminants entering the lake. Water samples collected during base flow and a February 2000 storm event were analyzed for selected cations, anions, trace elements, selected U.S. Environmental Protection Agency (EPA) primary and secondary drinkingwater contaminants, nitrogen isotopes, suspended solids, Escherichia coli, and pesticides. All of the water samples met the EPA drinking-water standards for inorganic constituents, except those collected at five sites in August 1999 during a drought. Nitrate nitrogen (NO3-N) concentrations were highest during base-flow conditions and displayed a dilutional trend during peak-flow periods. The NO3-N concentrations in water samples collected during the 2001 spring fertilizer applications tended to increase from early to late spring. All of the ??15N values were low, which is indicative of either an inorganic source or soil organic matter. Storm discharge contained increased concentrations of total suspended solids; thus, storms are responsible for most of the sediment accumulation in the lake. E. coli levels in 24% of the samples analyzed contained a most probable number (MPN) greater than 235/100 mL, which is the maximum acceptable level set for recreational waters in Indiana. E. coli does appear to be a potential health risk, particularly at Rubble spring. The sources of E. coli found at this spring may include barnyard runoff from a horse barn or wastes from a wastewater treatment facility. The pesticides atrazine, metolachlor

Correlating brain blood oxygenation level dependent (BOLD) fractal dimension mapping with magnetic resonance spectroscopy (MRS) in Alzheimer's disease.

PubMed

Warsi, Mohammed A; Molloy, William; Noseworthy, Michael D

2012-10-01

To correlate temporal fractal structure of resting state blood oxygen level dependent (rsBOLD) functional magnetic resonance imaging (fMRI) with in vivo proton magnetic resonance spectroscopy ((1)H-MRS), in Alzheimer's disease (AD) and healthy age-matched normal controls (NC). High temporal resolution (4 Hz) rsBOLD signal and single voxel (left putamen) magnetic resonance spectroscopy data was acquired in 33 AD patients and 13 NC. The rsBOLD data was analyzed using two types of fractal dimension (FD) analysis based on relative dispersion and frequency power spectrum. Comparisons in FD were performed between AD and NC, and FD measures were correlated with (1)H-MRS findings. Temporal fractal analysis of rsBOLD, was able to differentiate AD from NC subjects (P = 0.03). Low FD correlated with markers of AD severity including decreased concentrations of N-acetyl aspartate (R = 0.44, P = 0.015) and increased myoinositol (mI) (R = -0.45, P = 0.012). Based on these results we suggest fractal analysis of rsBOLD could provide an early marker of AD.

Influence of Locally Derived Recharge on the Water Quality and Temperature of Springs in Hot Springs National Park, Arkansas

USGS Publications Warehouse

Bell, Richard W.; Hays, Phillip D.

2007-01-01

The hot springs of Hot Springs National Park consist of a mixture of water from two recharge components: a primary hot-water component and a secondary cold-water component. Widespread distribution of fractures enables mixing of the hot- and cold-water components of flow near the discharge area for the springs. Urbanization in the area near the hot springs of Hot Springs National Park has increased the potential for degradation of the quality of surface-water runoff and locally derived ground-water recharge to the hot springs. Previous studies by the U.S. Geological Survey have indicated that water from some cold-water springs and wells in the vicinity of Hot Springs, Arkansas, showed evidence of contamination and that water from locally derived cold-water recharge might contribute 25 percent of the total flow to the hot springs after storms. Water samples were collected during base-flow conditions at nine hot springs and two cold-water springs in September 2000. Nine hot springs and one cold-water spring were resampled in October 2001 after a storm that resulted in a measurable decrease in water temperature in selected hot springs. Water samples were analyzed for a variety of dissolved chemical constituents (nutrients, major ions, trace elements, pesticides, semivolatile compounds, isotopes, and radiochemicals), physical properties, field measurements, and bacteria. Comparison of analyses of samples collected during base-flow conditions from the springs in 2000 and during a storm event in 2001 with the results from earlier studies dating back to the late 1800's indicates that little change in major, minor, and trace constituent chemistry has occurred and that the water continues to be of excellent quality. Water-quality data show distinguishable differences in water chemistry of the springs during base-flow and stormflow conditions, indicating changing input of cold-water recharge relative to hot-water recharge. Silica, total dissolved solids, strontium, barium

76 FR 46288 - Adequacy Determination for Colorado Springs, Cañon City, Greeley, Pagosa Springs, and Telluride...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-02

... Springs, Ca[ntilde]on City, Greeley, Pagosa Springs, and Telluride; Carbon Monoxide and PM 10 Maintenance... transportation conformity purposes: ``Revised Carbon Monoxide Attainment/Maintenance Plan Colorado Springs Attainment/ Maintenance Area'' and ``Revised Carbon Monoxide Maintenance Plan Greeley Attainment/Maintenance...

Region 8: Colorado Pagosa Springs Adequate Letter (8/17/2011)

EPA Pesticide Factsheets

This March 17, 2011 letter from EPA to Chistopher E. Urbina M.D., MPH, Colorado Department of Public Health and Environment states that EPA has found that the Pagosa Springs, CO PM10 maintenance plan and the 2021 motor vehicle emisssions budget (MVEB)

Grande Ronde Endemic Spring Chinook Salmon Supplementation Program: Monitoring and Evaluation, 2002 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boe, Stephen J.; Weldert, Rey F.; Crump, Carrie A.

2003-03-01

This is the fifth annual report of a multi-year project to operate adult collection and juvenile acclimation facilities on Catherine Creek and the upper Grande Ronde River for Snake River spring chinook salmon. These two streams have historically supported populations that provided significant tribal and non-tribal fisheries. Conventional and captive broodstock supplementation techniques are being used to restore spring chinook salmon fisheries in these streams. Statement of Work Objectives for 2002: (1) Plan for, administer, coordinate and assist comanagers in GRESCP M&E activities. (2) Evaluate performance of supplemented juvenile spring chinook salmon. (3) Evaluate life history differences between wild andmore » hatchery-origin (F{sub 1}) adult spring chinook salmon. (4) Describe life history characteristics and genetics of adult summer steelhead collected at weirs.« less

Plan of production of MeV laser electron photons at SPring-8

NASA Astrophysics Data System (ADS)

Arimoto, Y.; Ohkuma, H.; Suzuki, S.; Tamura, K.; Kumagai, N.; Okajima, S.; Fujiwara, M.

2001-10-01

MeV photons at SPring-8 are produced by backward Compton scattering (BCS) of far infrared (FIR) laser photons from a 8 GeV electron beam. The MeV photons are a powerful probe to study nuclear physics, astro-nuclear physics, nuclear engineering, condensed matter physics, etc. owing to their attractive properties such as small emittance, high intensity, high polarization, etc. The 10 MeV photons which can be produced by the BCS process between the 8 GeV electron of SPring-8 storage ring and FIR laser photons with a wavelength of ~100 μm have a great advantage. Since energy loss of the electron due to the BCS process is smaller than energy acceptance of the storage ring (±160 MeV), the stored electron beam is not lost. A stable CO_2-pumped FIR laser with the wavelength of ~100 μm is practically using as a probe of plasma diagnostics at a nuclear fusion reactor. Furthermore, since the laser has many oscillations in wide wavelength region, the BCS photons in wide range can be obtained. We plan to produce the MeV laser electron photons by the BCS at SPring-8. For these purpose, we are now developing a high power CO_2-pumped FIR laser. Up to now ~1.5 watts CW laser action at a wavelength of 118.8 μm has been achieved. In this meeting, we will present a current status of the FIR laser system, a plan of construction of the test beam-line for the production of MeV photons at SPring-8, and future plan of this project.

14 CFR 29.687 - Spring devices.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Spring devices. 29.687 Section 29.687... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Control Systems § 29.687 Spring devices. (a) Each control system spring device whose failure could cause flutter or other unsafe characteristics...

14 CFR 29.687 - Spring devices.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Spring devices. 29.687 Section 29.687... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Control Systems § 29.687 Spring devices. (a) Each control system spring device whose failure could cause flutter or other unsafe characteristics...

14 CFR 29.687 - Spring devices.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Spring devices. 29.687 Section 29.687... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Control Systems § 29.687 Spring devices. (a) Each control system spring device whose failure could cause flutter or other unsafe characteristics...

14 CFR 27.687 - Spring devices.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Spring devices. 27.687 Section 27.687... STANDARDS: NORMAL CATEGORY ROTORCRAFT Design and Construction Control Systems § 27.687 Spring devices. (a) Each control system spring device whose failure could cause flutter or other unsafe characteristics...

14 CFR 27.687 - Spring devices.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Spring devices. 27.687 Section 27.687... STANDARDS: NORMAL CATEGORY ROTORCRAFT Design and Construction Control Systems § 27.687 Spring devices. (a) Each control system spring device whose failure could cause flutter or other unsafe characteristics...

14 CFR 27.687 - Spring devices.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Spring devices. 27.687 Section 27.687... STANDARDS: NORMAL CATEGORY ROTORCRAFT Design and Construction Control Systems § 27.687 Spring devices. (a) Each control system spring device whose failure could cause flutter or other unsafe characteristics...

14 CFR 29.687 - Spring devices.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Spring devices. 29.687 Section 29.687... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Control Systems § 29.687 Spring devices. (a) Each control system spring device whose failure could cause flutter or other unsafe characteristics...

14 CFR 27.687 - Spring devices.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Spring devices. 27.687 Section 27.687... STANDARDS: NORMAL CATEGORY ROTORCRAFT Design and Construction Control Systems § 27.687 Spring devices. (a) Each control system spring device whose failure could cause flutter or other unsafe characteristics...

78 FR 16756 - International Civil Aviation Organization's (ICAO) Dangerous Goods Panel; Notice of Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-18

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration International Civil Aviation Organization's (ICAO) Dangerous Goods Panel; Notice of Public Meeting AGENCY: Federal Aviation Administration... Aviation Organization's (ICAO) Dangerous Goods Panel's (DGP's) Spring Working Group to be held April 15-19...

Characteristics of Students on Academic or Progress Probation, Spring 1992 through Spring 1995.

ERIC Educational Resources Information Center

Southwestern Coll., Chula Vista, CA.

Between spring 1992 and spring 1995, California's Southwestern College (SWC) conducted a study on the characteristics of students on academic or progress probation. The study was done as part of the Matriculation Research and Evaluation Plan to assess academic outcomes for SWC students. The report explores the demographic and educational…

Fall-to-Fall Testing versus Spring-to-Spring Testing: What Is the Impact on a Local Community's Chapter 1 Evaluation?

ERIC Educational Resources Information Center

Bushner, Diane E.

The impact of a decision by a local program under Chapter 1, the federally funded program of financial assistance to special educational needs of children, to test students fall-to-fall or spring-to-spring was studied. Students enrolled in a Chapter 1 reading program in 1988-89 were tested on a fall-to-spring basis, a spring-to-spring basis, and a…

Force delivery of Ni-Ti coil springs.

PubMed

Manhartsberger, C; Seidenbusch, W

1996-01-01

Sentalloy springs (GAC, Central Islip, N.Y.) of the open and closed type were investigated with a special designed device. The closed coil springs were subjected to a tensile and the open coil springs to a compression test. After a first measurement, the springs were activated for a period of 4 weeks and then reinvestigated with the same procedure. It could be shown distinctly that, with the different coil springs, the force delivery given by the producer could be achieved only within certain limits. To remain in the martensitic plateau, changed activation ranges, and for the Sentalloy coil springs white and red of the open and closed type, also changed force deliveries had to be taken into account. There was a distinct decrease in force delivery between the first and second measurement. After considering the loading curves of all the Sentalloy coil springs and choosing the right activation range respective to the force delivery, it was found that the coil springs deliver a superior clinical behavior and open new treatment possibilities.

Molecular biology of Homo sapiens: Abstracts of papers presented at the 51st Cold Spring Harbor symposium on quantitative biology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watson, J.D.; Siniscalco, M.

This volume contains abstracts of papers presented at the 51st Cold Springs Harbor Symposium on Quantitative Biology. The topic for this meeting was the ''Molecular Biology of Homo sapiens.'' Sessions were entitled Human Gene Map, Human Cancer Genes, Genetic Diagnosis, Human Evolution, Drugs Made Off Human Genes, Receptors, and Gene Therapy. (DT)

Buckling analysis of planar compression micro-springs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Jing; Sui, Li; Shi, Gengchen

2015-04-15

Large compression deformation causes micro-springs buckling and loss of load capacity. We analyzed the impact of structural parameters and boundary conditions for planar micro-springs, and obtained the change rules for the two factors that affect buckling. A formula for critical buckling deformation of micro-springs under compressive load was derived based on elastic thin plate theory. Results from this formula were compared with finite element analysis results but these did not always correlate. Therefore, finite element analysis is necessary for micro-spring buckling analysis. We studied the variation of micro-spring critical buckling deformation caused by four structural parameters using ANSYS software undermore » two constraint conditions. The simulation results show that when an x-direction constraint is added, the critical buckling deformation increases by 32.3-297.9%. The critical buckling deformation decreases with increase in micro-spring arc radius or section width and increases with increase in micro-spring thickness or straight beam width. We conducted experiments to confirm the simulation results, and the experimental and simulation trends were found to agree. Buckling analysis of the micro-spring establishes a theoretical foundation for optimizing micro-spring structural parameters and constraint conditions to maximize the critical buckling load.« less

Growth and Mortality of Coccolithophores during spring in the Celtic Sea

NASA Astrophysics Data System (ADS)

Mayers, K.; Poulton, A. J.; Giering, S. L. C.; Daniels, C. J.; Wells, S. R.; Tarran, G.

2016-02-01

Coccolithophores are an important group of single celled protists which dominate pelagic calcite production, however little is currently known about the mortality rates within this group, or their importance in shelf seas regarding productivity and nutrient recycling. Measurements of coccolithophore calcification and cellular calcite quotas, as well as dilution experiments for microzooplankton grazing rates, were made during a spring cruise (April, 2015) in the Celtic Sea (NW European Shelf) and within an April bloom of Emiliania huxleyi. Calcite production and coccolithophore cell numbers showed a general positive trend throughout the progression of the spring bloom, ranging from 15 - 34µmol C m-3d-1 and 6 - 94 cells ml-1. Cell normalised calcification rates declined from 3 - 0.6 pmol C cell-1d-1 due to a shift from a mixed community to an E. huxleyi dominated one. Within the E. huxleyi bloom we recorded high daily calcite production (6049 µmol C m-3d-1) and cell normalised calcification of 3 pmol C cell-1d-1. This is significantly higher than E. huxleyi dominated sites in the Iceland Basin and more similar to a bloom on the Patagonian Shelf. Within the E. huxleyi bloom, mortality rates were 0.23 d-1 compared with growth rates of 0.29 d-1, meaning 80% of daily calcification was removed by grazers. In this study, coccolithophore mortality rates are presented from the central Celtic Sea throughout spring, and compared with an April E. huxleyi bloom in terms of species composition, trends in calcite production and composition of the phytoplankton community. These observations will potentially elucidate the role grazing plays in the fate of calcium carbonate, bloom formation and community composition.

On Neglecting Chemical Exchange Effects When Correcting in Vivo 31P MRS Data for Partial Saturation

NASA Astrophysics Data System (ADS)

Ouwerkerk, Ronald; Bottomley, Paul A.

2001-02-01

Signal acquisition in most MRS experiments requires a correction for partial saturation that is commonly based on a single exponential model for T1 that ignores effects of chemical exchange. We evaluated the errors in 31P MRS measurements introduced by this approximation in two-, three-, and four-site chemical exchange models under a range of flip-angles and pulse sequence repetition times (TR) that provide near-optimum signal-to-noise ratio (SNR). In two-site exchange, such as the creatine-kinase reaction involving phosphocreatine (PCr) and γ-ATP in human skeletal and cardiac muscle, errors in saturation factors were determined for the progressive saturation method and the dual-angle method of measuring T1. The analysis shows that these errors are negligible for the progressive saturation method if the observed T1 is derived from a three-parameter fit of the data. When T1 is measured with the dual-angle method, errors in saturation factors are less than 5% for all conceivable values of the chemical exchange rate and flip-angles that deliver useful SNR per unit time over the range T1/5 ≤ TR ≤ 2T1. Errors are also less than 5% for three- and four-site exchange when TR ≥ T1*/2, the so-called "intrinsic" T1's of the metabolites. The effect of changing metabolite concentrations and chemical exchange rates on observed T1's and saturation corrections was also examined with a three-site chemical exchange model involving ATP, PCr, and inorganic phosphate in skeletal muscle undergoing up to 95% PCr depletion. Although the observed T1's were dependent on metabolite concentrations, errors in saturation corrections for TR = 2 s could be kept within 5% for all exchanging metabolites using a simple interpolation of two dual-angle T1 measurements performed at the start and end of the experiment. Thus, the single-exponential model appears to be reasonably accurate for correcting 31P MRS data for partial saturation in the presence of chemical exchange. Even in systems where

The effect of combining two echo times in automatic brain tumor classification by MRS.

PubMed

García-Gómez, Juan M; Tortajada, Salvador; Vidal, César; Julià-Sapé, Margarida; Luts, Jan; Moreno-Torres, Angel; Van Huffel, Sabine; Arús, Carles; Robles, Montserrat

2008-11-01

(1)H MRS is becoming an accurate, non-invasive technique for initial examination of brain masses. We investigated if the combination of single-voxel (1)H MRS at 1.5 T at two different (TEs), short TE (PRESS or STEAM, 20-32 ms) and long TE (PRESS, 135-136 ms), improves the classification of brain tumors over using only one echo TE. A clinically validated dataset of 50 low-grade meningiomas, 105 aggressive tumors (glioblastoma and metastasis), and 30 low-grade glial tumors (astrocytomas grade II, oligodendrogliomas and oligoastrocytomas) was used to fit predictive models based on the combination of features from short-TEs and long-TE spectra. A new approach that combines the two consecutively was used to produce a single data vector from which relevant features of the two TE spectra could be extracted by means of three algorithms: stepwise, reliefF, and principal components analysis. Least squares support vector machines and linear discriminant analysis were applied to fit the pairwise and multiclass classifiers, respectively. Significant differences in performance were found when short-TE, long-TE or both spectra combined were used as input. In our dataset, to discriminate meningiomas, the combination of the two TE acquisitions produced optimal performance. To discriminate aggressive tumors from low-grade glial tumours, the use of short-TE acquisition alone was preferable. The classifier development strategy used here lends itself to automated learning and test performance processes, which may be of use for future web-based multicentric classifier development studies. Copyright (c) 2008 John Wiley & Sons, Ltd.

Restoration of White Springs

Treesearch

Jonathan W. Long; Delbin Endfield

2000-01-01

Rock structures, road closures, fencing and revegetation methods were employed to restore a culturally and ecologically important spring that had been damaged in the aftermath of a wildfire. The project has reestablished the stability of the spring and has moved it closer to its former condition. School groups were an essential part of the restoration project, and...

A Magnet Spring Model

ERIC Educational Resources Information Center

Fay, T. H.; Mead, L.

2006-01-01

The paper discusses an elementary spring model representing the motion of a magnet suspended from the ceiling at one end of a vertical spring which is held directly above a second magnet fixed on the floor. There are two cases depending upon the north-south pole orientation of the two magnets. The attraction or repelling force induced by the…

Antibiotic susceptibility of methicillin-resistant staphylococci (MRS) of food origin: A comparison of agar disc diffusion method and a commercially available miniaturized test.

PubMed

Buzón-Durán, Laura; Capita, Rosa; Alonso-Calleja, Carlos

2018-06-01

Methicillin-resistant staphylococci (MRS) are a major concern to public and animal health. Thirty MRS (Staphylococcus aureus, S. cohnii, S. epidermidis, S. haemolyticus, S. hominis, S. lentus, S. lugdunensis, S. sciuri, and S. xylosus) isolates from meat and poultry preparations were tested for antimicrobial susceptibility to 11 antimicrobials (belonging to seven different categories) of clinical significance using both the standard agar disc diffusion method and a commercially available miniaturized system (Sensi Test Gram-positive). It is worth stressing that 16 isolates (53.33%) exhibited an extensively drug-resistant phenotype (XDR). The average number of resistances per strain was 4.67. These results suggest that retail meat and poultry preparations are a likely vehicle for the transmission of multi-drug resistant MRS. Resistance to erythromycin was the commonest finding (76.67% of strains), followed by tobramycin, ceftazidime (66.67%), ciprofloxacin (56.67%) and fosfomycin (53.33%). An agreement (kappa coefficient) of 0.64 was found between the two testing methods. Using the agar disc diffusion as the reference method, the sensitivity, specificity and accuracy of the miniaturized test were 98.44%, 69.44% and 83.33%, respectively. Most discrepancies between the two methods were due to isolates that were susceptible according to the disc diffusion method but resistant according to the miniaturized test (false positives). Copyright © 2017. Published by Elsevier Ltd.

Brain morphological alterations and cellular metabolic changes in patients with generalized anxiety disorder: A combined DARTEL-based VBM and (1)H-MRS study.

PubMed

Moon, Chung-Man; Jeong, Gwang-Woo

2016-05-01

Generalized anxiety disorder (GAD) is characterized by emotional dysregulation and cognitive deficit in conjunction with brain morphometric and metabolic alterations. This study assessed the combined neural morphological deficits and metabolic abnormality in patients with GAD. Thirteen patients with GAD and 13 healthy controls matched for age, sex, and education level underwent high-resolution T1-weighted MRI and proton magnetic resonance spectroscopy ((1)H-MRS) at 3Tesla. In this study, the combination of voxel-based morphometry (VBM) and (1)H-MRS was used to assess the brain morphometric and metabolic alterations in GAD. The patients showed significantly reduced white matter (WM) volumes in the midbrain (MB), precentral gyrus (PrG), dorsolateral prefrontal cortex (DLPFC) and anterior limb of the internal capsule (ALIC) compared to the controls. In MRS study, the choline/creatine (Cho/Cr) and choline/N-acetylaspartate (Cho/NAA) ratios in the DLPFC were significantly lower in the patients. Particularly, the WM volume variation of the DLPFC was positively correlated with both of the Cho/Cr and Cho/NAA ratios in patients with GAD. This study provides an evidence for the association between the morphometric deficit and metabolic changes in GAD. This finding would be helpful to understand the neural dysfunction and pathogenesis in connection with cognitive impairments in GAD. Copyright © 2015 Elsevier Inc. All rights reserved.

Assessment of Anterior Cingulate Cortex (ACC) and Left Cerebellar Metabolism in Asperger's Syndrome with Proton Magnetic Resonance Spectroscopy (MRS).

PubMed

Goji, Aya; Ito, Hiromichi; Mori, Kenji; Harada, Masafumi; Hisaoka, Sonoka; Toda, Yoshihiro; Mori, Tatsuo; Abe, Yoko; Miyazaki, Masahito; Kagami, Shoji

2017-01-01

Proton magnetic resonance spectroscopy (1H MRS) is a noninvasive neuroimaging method to quantify biochemical metabolites in vivo and it can serve as a powerful tool to monitor neurobiochemical profiles in the brain. Asperger's syndrome (AS) is a type of autism spectrum disorder, which is characterized by impaired social skills and restrictive, repetitive patterns of interest and activities, while intellectual levels and language skills are relatively preserved. Despite clinical aspects have been well-characterized, neurometabolic profiling in the brain of AS remains to be clear. The present study used proton magnetic resonance spectroscopy (1H MRS) to investigate whether pediatric AS is associated with measurable neurometabolic abnormalities that can contribute new information on the neurobiological underpinnings of the disorder. Study participants consisted of 34 children with AS (2-12 years old; mean age 5.2 (±2.0); 28 boys) and 19 typically developed children (2-11 years old; mean age 5.6 (±2.6); 12 boys) who served as the normal control group. The 1H MRS data were obtained from two regions of interest: the anterior cingulate cortex (ACC) and left cerebellum. In the ACC, levels of N-acetylaspartate (NAA), total creatine (tCr), total choline-containing compounds (tCho) and myo-Inositol (mI) were significantly decreased in children with AS compared to controls. On the other hand, no significant group differences in any of the metabolites were found in the left cerebellum. Neither age nor sex accounted for the metabolic findings in the regions. The finding of decreased levels of NAA, tCr, tCho, and mI in the ACC but not in left cerebellar voxels in the AS, suggests a lower ACC neuronal density in the present AS cohort compared to controls.

Brief Report: Approaches to [Superscript 31]P-MRS in Awake, Non-Sedated Children with and without Autism Spectrum Disorder

ERIC Educational Resources Information Center

Erickson, Laura C.; Scott-Van Zeeland, Ashley A.; Hamilton, Gavin; Lincoln, Alan; Golomb, Beatrice A.

2012-01-01

We piloted a suite of approaches aimed to facilitate a successful series of up to four brain and muscle [superscript 31]Phosphorus-Magnetic Resonance Spectroscopy ([superscript 31]P-MRS) scans performed in one session in 12 "awake", non-sedated subjects (ages 6-18), 6 with autism spectrum disorders (ASD) and 6 controls. We targeted advanced…

Predicting the patterns of change in spring onset and false springs in China during the twenty-first century

NASA Astrophysics Data System (ADS)

Zhu, Likai; Meng, Jijun; Li, Feng; You, Nanshan

2017-10-01

Spring onset has generally shifted earlier in China over the past several decades in response to the warming climate. However, future changes in spring onset and false springs, which will have profound effects on ecosystems, are still not well understood. Here, we used the extended form of the Spring Indices model (SI-x) to project changes in the first leaf and first bloom dates, and predicted false springs for the historical (1950-2005) and future (2006-2100) periods based on the downscaled daily maximum/minimum temperatures under two emission scenarios from 21 General Circulation Models (GCMs) of the Coupled Model Intercomparison Project Phase 5 (CMIP5). On average, first leaf and first bloom in China were projected to occur 21 and 23 days earlier, respectively, by the end of the twenty-first century in the Representative Concentration Pathway (RCP) 8.5 scenario. Areas with greater earlier shifts in spring onset were in the warm temperate zone, as well as the north and middle subtropical zones of China. Early false spring risk increased rapidly in the warm temperate and north subtropical zones, while that declined in the cold temperate zone. Relative to early false spring risk, late false spring risk showed a common increase with smaller magnitude in the RCP 8.5 scenario but might cause greater damage to ecosystems because plants tend to become more vulnerable to the later occurrence of a freeze event. We conclude that future climate warming will continue to cause earlier occurrence of spring onset in general, but might counterintuitively increase plant damage risk in natural and agricultural systems of the warm temperate and subtropical China.

Predicting the patterns of change in spring onset and false springs in China during the twenty-first century.

PubMed

Zhu, Likai; Meng, Jijun; Li, Feng; You, Nanshan

2017-10-28

Spring onset has generally shifted earlier in China over the past several decades in response to the warming climate. However, future changes in spring onset and false springs, which will have profound effects on ecosystems, are still not well understood. Here, we used the extended form of the Spring Indices model (SI-x) to project changes in the first leaf and first bloom dates, and predicted false springs for the historical (1950-2005) and future (2006-2100) periods based on the downscaled daily maximum/minimum temperatures under two emission scenarios from 21 General Circulation Models (GCMs) of the Coupled Model Intercomparison Project Phase 5 (CMIP5). On average, first leaf and first bloom in China were projected to occur 21 and 23 days earlier, respectively, by the end of the twenty-first century in the Representative Concentration Pathway (RCP) 8.5 scenario. Areas with greater earlier shifts in spring onset were in the warm temperate zone, as well as the north and middle subtropical zones of China. Early false spring risk increased rapidly in the warm temperate and north subtropical zones, while that declined in the cold temperate zone. Relative to early false spring risk, late false spring risk showed a common increase with smaller magnitude in the RCP 8.5 scenario but might cause greater damage to ecosystems because plants tend to become more vulnerable to the later occurrence of a freeze event. We conclude that future climate warming will continue to cause earlier occurrence of spring onset in general, but might counterintuitively increase plant damage risk in natural and agricultural systems of the warm temperate and subtropical China.

Travertine Hot Springs, Mono County, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chesterman, C.W.; Kleinhampl, F.J.

1991-08-01

This article is an abridgement of Special Report 172, Travertine Hot Springs at Bridgeport, Mono County, California, in preparation at the California Division of Mines and Geology. The Travertine Hot Springs area is on the northern edge of what many consider to be one of the most tectonically active areas in the United States. There is abundant geothermal and seismic activity. The landscape is dotted with volcanic features- cones, craters, domes, flows, fumaroles and hot springs-indicators of unrest in the present as well as reminders of activity in the past. Travertine, also known as calcareous sinter, is limestone formed bymore » chemical precipitation of calcium carbonate (CaCO{sub 3}) from ground or surface waters. It forms stalactites and stalagmites in caves, fills some veins and spring conduits and can also be found at the mouths of springs, especially hot springs. The less compact variety is called tufa and the dense, banded variety is known as Mexican onyx, or onyx marble. True onyx, however, is a banded silicate.« less

Fabrication and experimentation of FRP helical spring

NASA Astrophysics Data System (ADS)

Ekanthappa, J.; Shiva Shankar, G. S.; Amith, B. M.; Gagan, M.

2016-09-01

In present scenario, the automobile industry sector is showing increased interest in reducing the unsprung weight of the automobile & hence increasing the fuel Efficiency. One of the feasible sub systems of a vehicle where weight reduction may be attempted is vehicle- suspension system. Usage of composite material is a proven way to lower the component weight without any compromise in strength. The composite materials are having high specific strength, more elastic strain energy storage capacity in comparison with those of steel. Therefore, helical coil spring made of steel is replaceable by composite cylindrical helical coil spring. This research aims at preparing a re-usable mandrel (mould) of Mild steel, developing a setup for fabrication, fabrication of FRP helical spring using continuous glass fibers and Epoxy Resin (Polymer). Experimentation has been conducted on fabricated FRP helical spring to determine its strength parameters & for failure analysis. It is found that spring stiffness (K) of Glass/Epoxy helical-spring is greater than steel-coil spring with reduced weight.

A springs actuated finger exoskeleton: From mechanical design to spring variables evaluation.

PubMed

Bortoletto, Roberto; Mello, Ashley N; Piovesan, Davide

2017-07-01

In the context of post-stroke patients, suffering of hemiparesis of the hand, robot-aided neuro-motor rehabilitation allows for intensive rehabilitation treatments and quantitative evaluation of patients' progresses. This work presents the design and evaluation of a spring actuated finger exoskeleton. In particular, the spring variables and the interaction forces between the assembly and the hand were investigated, in order to assess the effectiveness of the proposed exoskeleton.

Mrs. Chandrasekhar addresses the media in TRW Media Hospitality Tent

NASA Technical Reports Server (NTRS)

1999-01-01

Mrs. Lalitha Chandrasekhar (at podium), wife of the late Indian- American Nobel Laureate Subrahmanyan Chandrasekhar, addresses the media and other invited guests in the TRW Media Hospitality Tent at the NASA Press Site at KSC. Other participants in the program (seated facing the audience, left to right) are the winners of the contest to rename the telescope, Jatila van der Veen, academic coordinator and lecturer, Physics Dept., University of Santa Barbara, Calif., and Tyrel Johnson, high school student, Laclede, Idaho; Joanne Maguire, vice-president and general manager, TRW Space & Laser Programs Division; and Dr. Alan Bunner, Science Program Director, Structure and Evolution of the Universe, Office of Space Science, NASA Headquarters, Washington, D.C. The name 'Chandra,' a shortened version of Chandrasekhar, was the name the Nobel Laureate preferred among friends and colleagues. 'Chandra' also means 'Moon' or 'luminous' in Sanskrit. The observatory is scheduled to be launched aboard Columbia on Space Shuttle mission STS-93.

Correction of craniosynostosis using modified spring-assisted surgery.

PubMed

Shen, Weimin; Cui, Jie; Chen, Jianbin; Zou, Jijun; Ji, Yi; Chen, Haini; Xiongzheng, Mu

2015-03-01

The use of springs in craniofacial surgery was originated at Sahlgrenska University Hospital in 1997 as a way of remodeling the cranial vault postoperatively. After a decade of development, spring technology has been improved to a greater extent. However, there still exist some problems, such as the poor consistency of steel wire stretches, the wrong position of steel wire, the problem of increasing the elasticity of springs, and so on. We have designed a spring device for external uses. This device is composed of 3 parts. The first part is the outside of the spring ring. This ring is the same as the internal spring, only a little bigger. The second part is a small U-shaped hook, which is made of titanium plates and linked to the skull portion. The U-shaped hook is approximately 1 cm long and 1 cm wide. The hang is approximately 1 cm long and 0.6 cm wide. The U-shaped level length is 1 cm, but the level width should be equal to or bigger than the thickness of the skull. The third part is a steel wire, which is placed at 1 end of hook. We first conduct a strip craniotomy, then put 2 hooks at the bone ends and, after that, fix hooks on the skull. Finally, we pull the steel wire of the hook end out of the scalp, connect it with the external spring, and draw out the external spring. We performed 24 craniofacial spring placement procedures for 12 patients with craniosynostosis. We used 6 springs for 3 patients who had anterior plagiocephaly, 12 springs for 6 patients who had scaphocephaly, and 3 springs for another patient who had metopic synostosis and holoprosencephaly. We also used 3 springs for 2 patients who had metopic synostosis. The 12 patients have not required further surgeries so far, and there were no major complications. Spring dislodgement had not caused any complication in early cases. We could easily change the position of the spring rings from outside the scalp, regularly correct the elasticity of the spring rings, and replace spring rings to increase

Portrait of a Geothermal Spring, Hunter's Hot Springs, Oregon.

PubMed

Castenholz, Richard W

2015-01-27

Although alkaline Hunter's Hot Springs in southeastern Oregon has been studied extensively for over 40 years, most of these studies and the subsequent publications were before the advent of molecular methods. However, there are many field observations and laboratory experiments that reveal the major aspects of the phototrophic species composition within various physical and chemical gradients of these springs. Relatively constant temperature boundaries demark the upper boundary of the unicellular cyanobacterium, Synechococcus at 73-74 °C (the world-wide upper limit for photosynthesis), and 68-70 °C the upper limit for Chloroflexus. The upper limit for the cover of the filamentous cyanobacterium, Geitlerinema (Oscillatoria) is at 54-55 °C, and the in situ lower limit at 47-48 °C for all three of these phototrophs due to the upper temperature limit for the grazing ostracod, Thermopsis. The in situ upper limit for the cyanobacteria Pleurocapsa and Calothrix is at ~47-48 °C, which are more grazer-resistant and grazer dependent. All of these demarcations are easily visible in the field. In addition, there is a biosulfide production in some sections of the springs that have a large impact on the microbiology. Most of the temperature and chemical limits have been explained by field and laboratory experiments.

Soft tissue modelling with conical springs.

PubMed

Omar, Nadzeri; Zhong, Yongmin; Jazar, Reza N; Subic, Aleksandar; Smith, Julian; Shirinzadeh, Bijan

2015-01-01

This paper presents a new method for real-time modelling soft tissue deformation. It improves the traditional mass-spring model with conical springs to deal with nonlinear mechanical behaviours of soft tissues. A conical spring model is developed to predict soft tissue deformation with reference to deformation patterns. The model parameters are formulated according to tissue deformation patterns and the nonlinear behaviours of soft tissues are modelled with the stiffness variation of conical spring. Experimental results show that the proposed method can describe different tissue deformation patterns using one single equation and also exhibit the typical mechanical behaviours of soft tissues.

Isolators Including Main Spring Linear Guide Systems

NASA Technical Reports Server (NTRS)

Goold, Ryan (Inventor); Buchele, Paul (Inventor); Hindle, Timothy (Inventor); Ruebsamen, Dale Thomas (Inventor)

2017-01-01

Embodiments of isolators, such as three parameter isolators, including a main spring linear guide system are provided. In one embodiment, the isolator includes first and second opposing end portions, a main spring mechanically coupled between the first and second end portions, and a linear guide system extending from the first end portion, across the main spring, and toward the second end portion. The linear guide system expands and contracts in conjunction with deflection of the main spring along the working axis, while restricting displacement and rotation of the main spring along first and second axes orthogonal to the working axis.

Yes, I May Become Ill and Someday I Will Die: Assessment and Treatment Considerations in the Case of Mrs. A.

ERIC Educational Resources Information Center

Asmundson, Gordon J. G.; Hadjistavrpolous, Heather D.

2004-01-01

Patients with health anxiety often present challenges to assessment and treatment planning. The case of Mrs. A. provides examples of several clinical issues common to these patients. Her symptoms cross several "DSM" diagnostic categories, with a primary presentation of hypochondriasis and secondary presentation of illness phobia. In this article,…

Microbiology and geochemistry of Little Hot Creek, a hot spring environment in the Long Valley Caldera.

PubMed

Vick, T J; Dodsworth, J A; Costa, K C; Shock, E L; Hedlund, B P

2010-03-01

A culture-independent community census was combined with chemical and thermodynamic analyses of three springs located within the Long Valley Caldera, Little Hot Creek (LHC) 1, 3, and 4. All three springs were approximately 80 degrees C, circumneutral, apparently anaerobic and had similar water chemistries. 16S rRNA gene libraries constructed from DNA isolated from spring sediment revealed moderately diverse but highly novel microbial communities. Over half of the phylotypes could not be grouped into known taxonomic classes. Bacterial libraries from LHC1 and LHC3 were predominantly species within the phyla Aquificae and Thermodesulfobacteria, while those from LHC4 were dominated by candidate phyla, including OP1 and OP9. Archaeal libraries from LHC3 contained large numbers of Archaeoglobales and Desulfurococcales, while LHC1 and LHC4 were dominated by Crenarchaeota unaffiliated with known orders. The heterogeneity in microbial populations could not easily be attributed to measurable differences in water chemistry, but may be determined by availability of trace amounts of oxygen to the spring sediments. Thermodynamic modeling predicted the most favorable reactions to be sulfur and nitrate respirations, yielding 40-70 kJ mol(-1) e(-) transferred; however, levels of oxygen at or below our detection limit could result in aerobic respirations yielding up to 100 kJ mol(-1) e(-) transferred. Important electron donors are predicted to be H(2), H(2)S, S(0), Fe(2+) and CH(4), all of which yield similar energies when coupled to a given electron acceptor. The results indicate that springs associated with the Long Valley Caldera contain microbial populations that show some similarities both to springs in Yellowstone and springs in the Great Basin.

CHARACTERIZATION OF WESTERN NORTH ATLANTIC RIGHT WHALE SPRING FEEDING HABITAT

EPA Science Inventory

The Great South Channel region of the southwestern Gulf of Maine, between George's Bank and Cape Cod, is the primary spring feeding ground for the western North Atlantic population of the I northern right whale, E. glacialis .Since this whale is so endangered, it is critical to i...

Prevalence and characterization of extended-spectrum beta-lactamase-producing Enterobacteriaceae in spring waters.

PubMed

Li, S; Zhu, Z C; Wang, L; Zhou, Y F; Tang, Y J; Miao, Z M

2015-12-01

The purpose of this study was to investigate the prevalence and characterization of extended-spectrum beta-lactamases (ESBL)-producing Enterobacteriaceae from spring waters in Mountain Tai of China. ESBL-producing Enterobacteriaceae were found in four out of 50 sampled spring waters (4/50, 8·0%) and a total of 16 non-duplicate ESBL-producing Enterobacteriaceae were obtained, including 13 Escherichia coli (E. coli) and three Klebsiella pneumoniae (Kl. pneumoniae). All 16 nonduplicate ESBL-producing Enterobacteriaceae isolates harboured genes encoding CTX-M ESBLs, among which six expressed CTX-M-15, five produced CTX-M-14, three produced CTX-M-55 and two expressed CTX-M-27. Four multilocus sequence types (ST) were found and ST131 was the dominant type (8/16, 50·0%). Taken together, the contamination of ESBL-producing Enterobacteriaceae were present in spring waters of Mountain Tai. The results indicated that spring waters could become a reservoir of antibiotic resistant bacteria and contribute to the spread of antimicrobial-resistant bacteria via drinking water or food chain. In addition, wastewater discharge of restaurants or hotels may be an important contribution source of antibiotic resistant bacteria in spring waters. © 2015 The Society for Applied Microbiology.

Phenological changes in bamboo carbohydrates explain the preference for culm over leaves by giant pandas (Ailuropoda melanoleuca) during spring.

PubMed

Knott, Katrina K; Christian, Amelia L; Falcone, Josephine F; Vance, Carrie K; Bauer, Laura L; Fahey, George C; Kouba, Andrew J

2017-01-01

Seasonal changes in the foodscape force herbivores to select different plant species or plant parts to meet nutritional requirements. We examined whether the search for calorie-rich carbohydrates explained giant panda's selection for bamboo culm over leaves during spring. Leaves and culms were collected from four Phyllostachys bamboos (P. aurea, P. aureosulcata, P. glauca, and P. nuda) once per month over 18-27 months. Monthly changes in annual plant part nutrients were examined, and compared to seasonal foraging behaviors of captive giant pandas. Although total fiber was greater (p<0.0001) in culm (85.6 ± 0.5%) than leaves (55.3 ± 0.4%) throughout the year, culm fiber was at its lowest in spring (79-85%) when culm selection by giant pandas exceeded 70% of their overall diet. Culm starch also was greatest (p = 0.044) during spring (5.5 ± 1.1%) and 2.5-fold the percentage of starch in leaves (2.2 ± 0.6%). The free sugars in spring culm consisted of a high proportion of glucose (35%) and fructose (47%), whereas sucrose made up 42% of the total free sugar content of spring leaves. Bound sugars in culm consisted of 60% glucose and 38% xylose likely representative of hemicellulose. The concentrations of bound sugars (hemicelluloses) in spring culms (543.7 ± 13.0 mg/g) was greater (p<0.001) than in leaves (373.0 ± 14.8 mg/g). These data help explain a long-standing question in giant panda foraging ecology: why consume the plant part with the lowest protein and fat during the energetically intensive spring breeding season? Giant pandas likely prefer spring culm that contains abundant mono- and polysaccharides made more bioavailable as a result of reduced fiber content. These data suggest that phenological changes in bamboo plant part nutrition drive foraging decisions by giant pandas.

Hot springs of the central Sierra Nevada, California

USGS Publications Warehouse

Mariner, R.H.; Presser, T.S.; Evans, William C.

1977-01-01

Thermal springs of the central Sierra Nevada issue dilute to slightly saline sodium chloride, sodium bicarbonate, or sodium mixed-anion waters ranging in pH from 6.4 to 9.3. The solubility of chalcedony appears to control the silica concentration in most of the spring waters. Fales Hot Springs may be associated with a higher temperature aquifer, 150 degrees Celsius or more, in which quartz is controlling the silica concentration. Carbon dioxide is the predominant gas escaping from Fales Hot Springs, the unnamed hot spring on the south side of Mono Lake, and the two thermal springs near Bridgeport. Most of the other thermal springs issue small amounts of gas consisting principally of nitrogen. Methane is the major component of the gas escaping from the unnamed spring on Paoha Island in Mono Lake. The deuterium and oxygen isotopic composition of most of the thermal waters are those expected for local meteoric water which has undergone minor water-rock reaction. The only exceptions are the hot spring on Paoha Island in Mono Lake and perhaps the unnamed warm spring (south side of Mono Lake) which issues mixtures of thermal water and saline lake water. (Woodard-USGS)

Korean Spring? An Analysis of the Arab Spring and Its Relevance for North Korea

DTIC Science & Technology

2012-06-08

Spring. North Korea is undergoing a transition following the death of Kim Jong II. This research thesis analyzed the conditions that existed during the...transition following the death of Kim Jong II. This research thesis analyzed the conditions that existed during the Arab Spring in Egypt, Libya and Syria...

Optical spring effect in nanoelectromechanical systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tian, Feng; Zhou, Guangya, E-mail: mpezgy@nus.edu.sg; Du, Yu

2014-08-11

In this Letter, we report a hybrid system consisting of nano-optical and nano-mechanical springs, in which the optical spring effect works to adjust the mechanical frequency of a nanoelectromechanical systems resonator. Nano-scale folded beams are fabricated as the mechanical springs and double-coupled one-dimensional photonic crystal cavities are used to pump the “optical spring.” The dynamic characteristics of this hybrid system are measured and analyzed at both low and high input optical powers. This study leads the physical phenomenon of optomechanics in complex nano-opto-electro-mechanical systems (NOEMS) and could benefit the future applications of NOEMS in chip-level communication and sensing.

Springs as hydrologic refugia in a changing climate? A remote sensing approach

USGS Publications Warehouse

Cartwright, Jennifer M.; Johnson, Henry M.

2018-01-01

Spring‐fed wetlands are ecologically important habitats in arid and semi‐arid regions. Springs have been suggested as possible hydrologic refugia from droughts and climate change; however, springs that depend on recent precipitation or snowmelt for recharge may be vulnerable to warming and drought intensification. Springs that are expected to maintain their ecohydrologic function in a warmer, drier climate may be priorities for conservation and restoration. Identifying such springs is difficult because many springs lack hydrologic records of adequate temporal extent and resolution to assess their resilience to water cycle changes. This study demonstrates proof‐of‐concept for the assessment of certain spring types (i.e., helocrene, hypocrene, and hillslope springs) in terms of hydrologic and ecological resilience to climatic water stress using freely available remote‐sensing and climate data. We used the Normalized Difference Vegetation Index (NDVI) from 1985 through 2011 to delineate surface‐moisture zones (SMZs) associated with 39 clusters of 172 springs in a montane sage‐steppe landscape in southeastern Oregon, USA. We developed and synthesized seven NDVI‐based indicators of SMZ resilience to interannual changes in water availability: (1) mean and (2) standard deviation of July NDVI; (3) mean difference in July NDVI and (4) difference in coefficient of variation for July NDVI between each SMZ and its surrounding watershed; (5) response of SMZ July NDVI to 90‐day antecedent precipitation; (6) response of SMZ July NDVI to the previous winter's snowpack; and (7) range of NDVI values from an exceptionally wet year followed by three dry years. Because all resilience indicators were highly inter‐correlated, we derived an overall metric of SMZ resilience using principal components analysis that accounted for 66% of total variance. This overall resilience score was positively correlated with SMZ elevation, slope, mean annual precipitation, and with

Corrrective action decision document for the Cactus Spring Waste Trenches (Corrective Action Unit No. 426). Revision No. 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The Corrective Action Decision Document (CADD) for the Cactus Spring Waste Trenches (Corrective Action Unit [CAU] No. 426) has been prepared for the US Department of Energy`s (DOE) Nevada Environmental Restoration Project. This CADD has been developed to meet the requirements of the Federal Facility Agreement and Consent Order (FFACO) of 1996, stated in Appendix VI, {open_quotes}Corrective Action Strategy{close_quotes} (FFACO, 1996). The Cactus Spring Waste Trenches Corrective Action Site (CAS) No. RG-08-001-RG-CS is included in CAU No. 426 (also referred to as the {open_quotes}trenches{close_quotes}); it has been identified as one of three potential locations for buried, radioactively contaminated materials frommore » the Double Tracks Test. The trenches are located on the east flank of the Cactus Range in the eastern portion of the Cactus Spring Ranch at the Tonopah Test Range (TTR) in Nye County, Nevada, on the northern portion of Nellis Air Force Range. The TTR is approximately 225 kilometers (km) (140 miles [mi]) northwest of Las Vegas, Nevada, by air and approximately 56 km (35 mi) southeast of Tonopah, Nevada, by road. The trenches were dug for the purpose of receiving waste generated during Operation Roller Coaster, primarily the Double Tracks Test. This test, conducted in 1963, involved the use of live animals to assess the biological hazards associated with non-nuclear detonation of plutonium-bearing devices (i.e., inhalation uptake of plutonium aerosol). The CAS consists of four trenches that received solid waste and had an overall impacted area of approximately 36 meters (m) (120 feet [ft]) long x 24 m (80 ft) wide x 3 to 4.5 m (10 to 15 ft) deep. The average depressions at the trenches are approximately 0.3 m (1 ft) below land surface.« less

Technical Note: Initial assessment of a multi-method approach to spring-flood forecasting in Sweden

NASA Astrophysics Data System (ADS)

Olsson, J.; Uvo, C. B.; Foster, K.; Yang, W.

2016-02-01

Hydropower is a major energy source in Sweden, and proper reservoir management prior to the spring-flood onset is crucial for optimal production. This requires accurate forecasts of the accumulated discharge in the spring-flood period (i.e. the spring-flood volume, SFV). Today's SFV forecasts are generated using a model-based climatological ensemble approach, where time series of precipitation and temperature from historical years are used to force a calibrated and initialized set-up of the HBV model. In this study, a number of new approaches to spring-flood forecasting that reflect the latest developments with respect to analysis and modelling on seasonal timescales are presented and evaluated. Three main approaches, represented by specific methods, are evaluated in SFV hindcasts for the Swedish river Vindelälven over a 10-year period with lead times between 0 and 4 months. In the first approach, historically analogue years with respect to the climate in the period preceding the spring flood are identified and used to compose a reduced ensemble. In the second, seasonal meteorological ensemble forecasts are used to drive the HBV model over the spring-flood period. In the third approach, statistical relationships between SFV and the large-sale atmospheric circulation are used to build forecast models. None of the new approaches consistently outperform the climatological ensemble approach, but for early forecasts improvements of up to 25 % are found. This potential is reasonably well realized in a multi-method system, which over all forecast dates reduced the error in SFV by ˜ 4 %. This improvement is limited but potentially significant for e.g. energy trading.

Spring loaded locator pin assembly

DOEpatents

Groll, Todd A.; White, James P.

1998-01-01

This invention deals with spring loaded locator pins. Locator pins are sometimes referred to as captured pins. This is a mechanism which locks two items together with the pin that is spring loaded so that it drops into a locator hole on the work piece.

fMRI and MRS measures of neuroplasticity in the pharyngeal motor cortex

PubMed Central

Michou, Emilia; Williams, Steve; Vidyasagar, Rishma; Downey, Darragh; Mistry, Satish; Edden, Richard A.E.; Hamdy, Shaheen

2016-01-01

Introduction Paired associative stimulation (PAS), is a novel non-invasive technique where two neural substrates are employed in a temporally coordinated manner in order to modulate cortico-motor excitability within the motor cortex (M1). In swallowing, combined pharyngeal electrical and transcranial-magnetic-stimulation induced beneficial neurophysiological and behavioural effects in healthy subjects and dysphagic stroke patients. Here, we aimed to investigate the whole-brain changes in neural activation during swallowing using functional magnetic resonance imaging (fMRI) following PAS application and in parallel assess associated GABA changes with magnetic resonance spectroscopy (MRS). Methods Healthy adults (n = 11, 38 ± 9 years old) were randomised to receive real and sham PAS to the ‘stronger’ motor cortex pharyngeal representation, on 2 separate visits. Following PAS, event-related fMRI was performed to assess changes in brain activation in response to water and saliva swallowing and during rest. Data were analysed (SPM8) at P < .001. MRS data were acquired using MEGA-PRESS before and after the fMRI acquisitions on both visits and GABA concentrations were measured (AMARES, jMRUI). Results Following real PAS, BOLD signal changes (group analyses) increased at the site of stimulation during water and saliva swallowing, compared to sham PAS. It is also evident that PAS induced significant increases in BOLD signal to contralateral (to stimulation) hemispheric areas that are of importance to the swallowing neural network. Following real PAS, GABA: creatine ratio showed a trend to increase contralateral to PAS. Conclusion Targeted PAS applied to the human pharyngeal motor cortex induces local and remote changes in both primary and non-primary areas for water and saliva tasks. There is a possibility that changes of the inhibitory neurotransmitter, GABA, may play a role in the changes in BOLD signal. These findings provide evidence for the mechanisms underlying

Muscle-spring dynamics in time-limited, elastic movements.

PubMed

Rosario, M V; Sutton, G P; Patek, S N; Sawicki, G S

2016-09-14

Muscle contractions that load in-series springs with slow speed over a long duration do maximal work and store the most elastic energy. However, time constraints, such as those experienced during escape and predation behaviours, may prevent animals from achieving maximal force capacity from their muscles during spring-loading. Here, we ask whether animals that have limited time for elastic energy storage operate with springs that are tuned to submaximal force production. To answer this question, we used a dynamic model of a muscle-spring system undergoing a fixed-end contraction, with parameters from a time-limited spring-loader (bullfrog: Lithobates catesbeiana) and a non-time-limited spring-loader (grasshopper: Schistocerca gregaria). We found that when muscles have less time to contract, stored elastic energy is maximized with lower spring stiffness (quantified as spring constant). The spring stiffness measured in bullfrog tendons permitted less elastic energy storage than was predicted by a modelled, maximal muscle contraction. However, when muscle contractions were modelled using biologically relevant loading times for bullfrog jumps (50 ms), tendon stiffness actually maximized elastic energy storage. In contrast, grasshoppers, which are not time limited, exhibited spring stiffness that maximized elastic energy storage when modelled with a maximal muscle contraction. These findings demonstrate the significance of evolutionary variation in tendon and apodeme properties to realistic jumping contexts as well as the importance of considering the effect of muscle dynamics and behavioural constraints on energy storage in muscle-spring systems. © 2016 The Author(s).

Radioactivity of Nevada hot-spring systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wollenberg, H.A.

1974-01-01

Field gamma radiometry and laboratory gamma spectrometry of waters and spring deposits were accomplished for some hot-sprin systems in northern Nevada. Gamma dose rates measured on-site range from 2 to 500 mu rphr, and depend msinly on the amounts of the natural radioelements in the spring deposits. At several locations /sup 222/Rn, emanating from the water, casuses recognizable ganna anomalies. High radioactivities, primarily from /sup 226/Ra, are associated with hot-spring systems dominated by CaCO/sub 3/, while silica-dominated systems sre relatively low in radioactivity. Gamma spectrometry disclosed the enrichment of / sup 226/Ra with respect to its parent U in CaCO/submore » 3/-dominated systems. /sup 226/Ra preferentially associates with Ca; therefore, where tufa and siliceous sinter are present in a deposit, the calcareous material is highest in radioacnvity. Spring deposits at fast-flowing CaCO/sub 3/-dominated systems are generally less radioactive than calcareous deposits at slower flowing springs. (auth)« less

Acoustic doppler velocity monitoring within Main Spring, Barton Springs, Austin, Texas, April-September 2004-enhancing the accuracy of springflow data

USGS Publications Warehouse

Asquith, W.H.; Gary, M.O.

2005-01-01

Acoustic Doppler velocity (ADV) meters are sophisticated underwater monitoring instruments that use sound waves to measure water velocity in as many as three directions. In April 2004, an ADV meter was installed inside the principal orifice and discharge point of Main Spring at Barton Springs in Austin, Texas. This instrument collects velocity data that can be used to enhance the accuracy of springflow data and identify previously unrecognized hydrologic patterns.An accurate record of springflow at Barton Springs is important for several reasons. First, Barton Springs is the only known habitat for the Barton Springs salamander (Eurycea sosorum), a federally-listed endangered species that is dependent on reliable springflow to survive. Determination of sustainable Edwards aquifer yields compatible with the survival of the species is impossible without an accurate springflow record. Second, the 3-acre swimming pool fed by Barton Springs is enjoyed by about 340,000 people per year (2003) and is an important tourist attraction. Third, Barton Springs provides a part of Austin's municipal water supply; water from Barton Springs discharges into Town Lake on the Colorado River about 0.4 mile upstream from one of Austin's three water-supply plants. Fourth, flow in Barton Springs reflects water levels in the Barton Springs segment of the Edwards aquifer, which currently (2005) is designated a sole-source aquifer by the U.S. Environmental Protection Agency. This report, prepared by the U.S. Geological Survey, briefly summarizes the results of recent ADV-based velocity and springflow data acquisition at Barton Springs and describes an application of velocity monitoring to enhance the accuracy of springflow data.

9. Photocopy of photograph showing myrtlecovered spring. The original photograph ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photocopy of photograph showing myrtle-covered spring. The original photograph was taken on May 21, 1936 by Edouard E. Exline and is one of five photographs in the album, 'A Sketch of Mountain Life: Great Smoky Mountains National Park', compiled by Edouard E. Exline and C.S. Grossman. The album is on file at the Great Smoky Mountains National Park; the photograph number is II-B-(7)-8096. - Walker Family Farm (General views), Gatlinburg, Sevier County, TN

What to Do with the Spring Ligament.

PubMed

Steginsky, Brian; Vora, Anand

2017-09-01

The spring ligament complex is an important static restraint of the medial longitudinal arch of the foot and its failure has been associated with progressive flatfoot deformity. Reconstruction of the spring ligament complex is most appropriate in stage II posterior tibial tendon dysfunction, before severe peritalar subluxation and rigid deformity develops. Although an understanding of the spring ligament complex and its contribution to medial arch stability has grown, there is no unanimously accepted surgical technique that has consistently demonstrated satisfactory outcomes. This article reviews the pathoanatomy of the spring ligament complex and the role of spring ligament reconstruction in acquired flatfoot deformity, and highlights current research. Copyright © 2017 Elsevier Inc. All rights reserved.

Psychometric Properties of Spanish Adaptation of the PDD-MRS Scale in Adults with Intellectual Developmental Disorders: The EVTEA-DI Scale

ERIC Educational Resources Information Center

Cortés, Maria José; Orejuela, Carmen; Castellví, Gemma; Folch, Annabel; Rovira, Lluís; Salvador-Carulla, Luis; Irazábal, Marcia; Muñoz, Silvia; Haro, Josep Maria; Vilella, Elisabet; Martínez-Leal, Rafael

2018-01-01

Strategies for the early detection of autism spectrum disorders (ASD) in people with intellectual developmental disorder (IDD) are urgently needed, but few specific tools have been developed. The present study examines the psychometric properties of the EVTEA-DI, a Spanish adaptation of the PDD-MRS, in a large randomized sample of 979 adults with…

Spring loaded locator pin assembly

DOEpatents

Groll, T.A.; White, J.P.

1998-03-03

This invention deals with spring loaded locator pins. Locator pins are sometimes referred to as captured pins. This is a mechanism which locks two items together with the pin that is spring loaded so that it drops into a locator hole on the work piece. 5 figs.

In vivo (1)H MRS and (31)P MRSI of the response to cyclocreatine in transgenic mouse liver expressing creatine kinase.

PubMed

Cui, Min-Hui; Jayalakshmi, Kamaiah; Liu, Laibin; Guha, Chandan; Branch, Craig A

2015-12-01

Hepatocyte transplantation has been explored as a therapeutic alternative to liver transplantation, but a means to monitor the success of the procedure is lacking. Published findings support the use of in vivo (31)P MRSI of creatine kinase (CK)-expressing hepatocytes to monitor proliferation of implanted hepatocytes. Phosphocreatine tissue level depends upon creatine (Cr) input to the CK enzyme reaction, but Cr measurement by (1)H MRS suffers from low signal-to-noise ratio (SNR). We examine the possibility of using the Cr analog cyclocreatine (CCr, a substrate for CK), which is quickly phosphorylated to phosphocyclocreatine (PCCr), as a higher SNR alternative to Cr. (1)H MRS and (31)P MRSI were employed to measure the effect of incremental supplementation of CCr upon PCCr, γ-ATP, pH and Pi /ATP in the liver of transgenic mice expressing the BB isoform of CK (CKBB) in hepatocytes. Water supplementation with 0.1% CCr led to a peak total PCCr level of 17.15 ± 1.07 mmol/kg wet weight by 6 weeks, while adding 1.0% CCr led to a stable PCCr liver level of 18.12 ± 3.91 mmol/kg by the fourth day of feeding. PCCr was positively correlated with CCr, and ATP concentration and pH declined with increasing PCCr. Feeding with 1% CCr in water induced an apparent saturated level of PCCr, suggesting that CCr quantization may not be necessary for quantifying expression of CK in mice. These findings support the possibility of using (31)P MRS to noninvasively monitor hepatocyte transplant success with CK-expressing hepatocytes. Copyright © 2015 John Wiley & Sons, Ltd.

Shingle Springs Band of Miwok Indians/Shingle Springs Rancheria: Express Fuel General Air Quality Permit Application

EPA Pesticide Factsheets

Shingle Springs Rancheria/Shingle Springs Band of Miwok Indians/Express Fuel Request for Coverage under the General Air Quality Permit for New or Modified Minor Source Gasoline Dispensing Facilities in Indian Country within California.

Biogeographic patterns of desert springs in the Great Basin with an emphasis on regional aquifer thermal springs as refugia for vulnerable crenobiotic species

NASA Astrophysics Data System (ADS)

Forrest, M.; Sada, D. W.; Norris, R. D.

2013-12-01

The desert springs of the Great Basin Region in western North America provide ideal systems to study biogeographic and evolutionary patterns. In arid regions, springs are biodiversity hotspots because they often provide the sole source of water for the biota within and around them. In the Great Basin, springs provide critical habitat for diverse and extensive crenobiotic flora and fauna comprising over 125 endemic species. These aquatic environments represent island ecosystems surrounded by seas of desert, and researchers have compiled large databases of their biota and chemistry. Consequently, desert springs are excellent systems for biogeographic studies and multivariate statistical analyses of relationships between the chemical and physical characteristics of the springs and the biological communities that they support. The purpose of this study is to elucidate the relationships between the physicochemical characteristics of springs and their biota using multivariate statistical analyses to characterize 1325 springs, including regional aquifer springs, local aquifer cold springs and geothermal springs. The analyses reveal that regional aquifer thermal springs harbor disproportionate numbers of crenobiotic species including endemic gastropods, fishes, and aquatic insects. However, these regional aquifer springs also contain significantly more introduced species than cold and geothermal local aquifer springs. Springs are threatened by anthropogenic impacts including groundwater depletion and pollution, alteration of flow regimes, and the introduction of exotic species. In this study, one of the major factors that distinguished regional aquifer thermal springs from cold and geothermal local aquifer springs was the higher number of introduced species found in regional aquifer springs. This may be due to the influences of the same physicochemical characteristics that allow regional aquifer springs to serve as refugia for endemic species--species that are able to gain

Thermal springs of Malaysia and their potentialdevelopment

NASA Astrophysics Data System (ADS)

Rahim Samsudin, Abdul; Hamzah, Umar; Rahman, Rakmi Ab.; Siwar, Chamhuri; Fauzi Mohd. Jani, Mohd; Othman, Redzuan

The study on the potential development of hot springs for the tourism industry in Malaysiawas conducted. Out of the 40 hot springs covered, the study identified 9 hot springs having a high potential for development, 14 having medium potential and the remaining 17 having low or least potential for development. This conclusion was arrived at after considering the technical and economic feasibility of the various hot springs. Technical feasibility criteria includes geological factors, water quality, temperature and flow rate. The economic feasibility criteria considers measures such as accessibility, current and market potentials in terms of visitors, surrounding attractions and existing inventory and facilities available. A geological input indicates that high potential hot springs are located close to or within the granite body and associated with major permeable fault zones. They normally occur at low elevation adjacent to topographic highs. High potential hot springs are also characterised by high water temperature, substantial flowrate and very good water quality which is important for water-body contact activities such as soaking. Economic criteria for high potential hot springs are associated with good accessibility, good market, good surrounding attractions like rural and village setting and well developed facilities and infrastructures.

Some investigations of the deposition of travertine from Hot Springs-I. The isotopic chemistry of a travertine-depositing spring

USGS Publications Warehouse

Friedman, I.

1970-01-01

The isotopic compositions of the travertine and of the hot spring solutions were studied at Main Springs and New Highland Terrace in the Mammoth Hot Springs area of Yellowstone Park. The springs issue at 74??C and a pH of 6.65 and the carbon isotopic composition of the travertine depositing at the orifice is +2%.??C13 (PDB). As the water travels out from the orifice, it cools and loses CO2. The travertine depositing at lower temperature is enriched in C13, reaching values of +4.8%. and the solution has a pH of 8.2 at 27??C. The ??C13 of the carbon species in solution is about -2.3%. at 74?? and about +4.3 at 27??C. Therefore, the difference in ??C13 between the solid and solution is approximately 4%. at 74?? and decreases to zero at about 20??C. These differences are shown to be due to kinetic (non-equilibrium) factors. The ??O18 contents of the travertine and water show that in most samples the carbonate oxygen is in equilibrium with the water O18 at the temperatures of deposition. This is especially true for travertine depositing slowly and at temperatures above about 50??C. Calculations based on pH and alkalinity titrations of the hot spring waters in situ show that at the spring orifice the water is very high in free CO2, which is quickly lost in transit. The springs are supersaturated with respect to both aragonite and calcite during most of their travel in the open air. The carbon isotopic composition of the travertine is similar to that in the marine carbonates that are adjacent to the springs and that are the probable source of the calcium carbonate. The travertine from inactive prehistoric springs near Mammoth has similar ??C13 and O18 to that from the active springs. Soda Butte, an inactive center 25 miles east of Mammoth, contains heavier carbon and oxygen than the springs near Mammoth. ?? 1970.

Quantitative imaging of brain energy metabolisms and neuroenergetics using in vivo X-nuclear 2H, 17O and 31P MRS at ultra-high field.

PubMed

Zhu, Xiao-Hong; Lu, Ming; Chen, Wei

2018-07-01

Brain energy metabolism relies predominantly on glucose and oxygen utilization to generate biochemical energy in the form of adenosine triphosphate (ATP). ATP is essential for maintaining basal electrophysiological activities in a resting brain and supporting evoked neuronal activity under an activated state. Studying complex neuroenergetic processes in the brain requires sophisticated neuroimaging techniques enabling noninvasive and quantitative assessment of cerebral energy metabolisms and quantification of metabolic rates. Recent state-of-the-art in vivo X-nuclear MRS techniques, including 2 H, 17 O and 31 P MRS have shown promise, especially at ultra-high fields, in the quest for understanding neuroenergetics and brain function using preclinical models and in human subjects under healthy and diseased conditions. Copyright © 2018 Elsevier Inc. All rights reserved.

Linking atmospheric blocking to European temperature extremes in spring

NASA Astrophysics Data System (ADS)

Brunner, Lukas; Hegerl, Gabriele; Steiner, Andrea

2017-04-01

The weather in Europe is influenced by a range of dynamical features such as the Atlantic storm tracks, the jet stream, and atmospheric blocking. Blocking describes an atmospheric situation in which a stationary and persistent high pressure system interrupts the climatological flow for several days to weeks. It can trigger cold and warm spells which is of special relevance during the spring season because vegetation is particularly vulnerable to extreme temperatures in the early greening phase. We investigate European cold and warm spells in the 36 springs from 1979 to 2014 in temperature data from the European daily high-resolution gridded dataset (E-OBS) and connect them to blocking derived from geopotential height fields from ERA-Interim. A highly significant link between blocking and both, cold and warm spells is found that changes during spring. Resolving monthly frequencies, we find a shift in the preferred locations of blocking throughout spring. The maximum blocking frequency during cold spells shifts from Scandinavia to the British Isles in March and April. During warm spells it continuously shifts further northward during the spring season. The location of the block is found to be essential for the sign of the relationship. Blocking over the north-eastern Atlantic and over northern Europe is strongly linked to cold conditions, while blocking over central Europe is associated with warm conditions. Consistently the spatial distribution of temperature extremes across Europe is highly sensitive to the occurrence of blocking. More than 80 % of cold spells in south-eastern Europe occur during blocking, compared to less than 30 % in northern Europe. Warm spells show the opposite pattern and more than 70 % co-occur with blocking in northern Europe, compared to less than 30 % in parts of southern Europe. We find considerable interannual variability over the analysis period from 1979 to 2014 but also a decrease in cold spells and an increase in warm spells

The effects of monsoons and climate teleconnections on the Niangziguan Karst Spring discharge in North China

NASA Astrophysics Data System (ADS)

Zhang, Juan; Hao, Yonghong; Hu, Bill X.; Huo, Xueli; Hao, Pengmei; Liu, Zhongfang

2017-01-01

Karst aquifers supply drinking water for 25 % of the world's population, and they are, however, vulnerable to climate change. This study is aimed to investigate the effects of various monsoons and teleconnection patterns on Niangziguan Karst Spring (NKS) discharge in North China for sustainable exploration of the karst groundwater resources. The monsoons studied include the Indian Summer Monsoon, the West North Pacific Monsoon and the East Asian Summer Monsoon. The climate teleconnection patterns explored include the Indian Ocean Dipole, E1 Niño Southern Oscillation, and the Pacific Decadal Oscillation. The wavelet transform and wavelet coherence methods are used to analyze the karst hydrological processes in the NKS Basin, and reveal the relations between the climate indices with precipitation and the spring discharge. The study results indicate that both the monsoons and the climate teleconnections significantly affect precipitation in the NKS Basin. The time scales that the monsoons resonate with precipitation are strongly concentrated on the time scales of 0.5-, 1-, 2.5- and 3.5-year, and that climate teleconnections resonate with precipitation are relatively weak and diverged from 0.5-, 1-, 2-, 2.5-, to 8-year time scales, respectively. Because the climate signals have to overcome the resistance of heterogeneous aquifers before reaching spring discharge, with high energy, the strong climate signals (e.g. monsoons) are able to penetrate through aquifers and act on spring discharge. So the spring discharge is more strongly affected by monsoons than the climate teleconnections. During the groundwater flow process, the precipitation signals will be attenuated, delayed, merged, and changed by karst aquifers. Therefore, the coherence coefficients between the spring discharge and climate indices are smaller than those between precipitation and climate indices. Further, the fluctuation of the spring discharge is not coincident with that of precipitation in most

Mineral springs and miracles.

PubMed Central

Forster, M. M.

1994-01-01

Development of hot springs in the Canadian Rockies was closely linked to their reputed medicinal value. In 1885, the federal government created a small reserve around the springs at Sulphur Mountain, an area later enlarged to become Banff National Park, in recognition of the "great sanitary and curative advantage to the public." Images p730-a p731-a p732-a p733-a p734-a p736-a PMID:8199525

14 CFR 29.687 - Spring devices.

Code of Federal Regulations, 2013 CFR

2013-01-01

... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Control Systems § 29.687 Spring devices. (a) Each control system spring device whose failure could cause flutter or other unsafe characteristics...

14 CFR 27.687 - Spring devices.

Code of Federal Regulations, 2013 CFR

2013-01-01

... STANDARDS: NORMAL CATEGORY ROTORCRAFT Design and Construction Control Systems § 27.687 Spring devices. (a) Each control system spring device whose failure could cause flutter or other unsafe characteristics...

Analyzing spring pendulum phenomena with a smart-phone acceleration sensor

NASA Astrophysics Data System (ADS)

Kuhn, Jochen; Vogt, Patrik

2012-11-01

This paper describes two further pendulum experiments using the acceleration sensor of a smartphone in this column (for earlier contributions concerning this topic, including the description of the operation and use of the acceleration sensor, see Refs. 1 and 2). In this paper we focus on analyzing spring pendulum phenomena. Therefore two spring pendulum experiments will be described in which a smartphone is used as a pendulum body and SPARKvue3 software is used in conjunction with an iPhone or an iPod touch, or the Accelogger4 app for an Android device.1,2 As described in Ref. 1, the values measured by the smartphone are subsequently exported to a spreadsheet application (e.g., MS Excel) for analysis.

The predictive value of baseline NAA/Cr for treatment response of first-episode schizophrenia: A ¹H MRS study.

PubMed

Liu, Weibo; Yu, Hualiang; Jiang, Biao; Pan, Bing; Yu, Shaohua; Li, Huichun; Zheng, Leilei

2015-07-23

The study focused on the predictive value of baseline metabolite ratios in bilateral hippocampus of first-episode schizophrenia by using proton magnetic resonance spectroscopy ((1)H MRS). (1)H MRS data were acquired from 23 hallucination and 17 non-hallucination first-episode schizophrenia patients compared with 17 healthy participants. Clinical characteristics of patients were rated using the Positive and Negative Syndrome Scale (PANSS) before and after 3-month treatment. The schizophrenia patients showed lower NAA/Cr ratio than healthy participants respectively (p=0.024; p=0.001), and non-hallucination patients had even lower NAA/Cr ratio than hallucination patients (p=0.033). After 3-month treatment, hallucination patients had greater improvement in negative symptoms than non-hallucination patients (p=0.018). The reduction of PANSS total score and negative factor score was positively correlated with the left NAA/Cr in both group patients (p<0.05). Given that the bilateral hippocampal baseline NAA/Cr had predictive value for the whole treatment response, and the left hippocampal NAA/Cr can predict the prognosis of negative symptoms during acute phase medication in first-episode schizophrenia. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Spring leaf phenology and the diurnal temperature range in a temperate maple forest.

PubMed

Hanes, Jonathan M

2014-03-01

Spring leaf phenology in temperate climates is intricately related to numerous aspects of the lower atmosphere [e.g., surface energy balance, carbon flux, humidity, the diurnal temperature range (DTR)]. To further develop and improve the accuracy of ecosystem and climate models, additional investigations of the specific nature of the relationships between spring leaf phenology and various ecosystem and climate processes are required in different environments. This study used visual observations of maple leaf phenology, below-canopy light intensities, and micrometeorological data collected during the spring seasons of 2008, 2009, and 2010 to examine the potential influence of leaf phenology on a seasonal transition in the trend of the DTR. The timing of a reversal in the DTR trend occurred near the time when the leaves were unfolding and expanding. The results suggest that the spring decline in the DTR can be attributed primarily to the effect of canopy closure on daily maximum temperature. These findings improve our understanding of the relationship between leaf phenology and the diurnal temperature range in temperate maple forests during the spring. They also demonstrate the necessity of incorporating accurate phenological data into ecosystem and climate models and warrant a careful examination of the extent to which canopy phenology is currently incorporated into existing models.

Map showing springs in the Salina quadrangle, Utah

USGS Publications Warehouse

Covington, Harry R.

1972-01-01

A spring is “a place where, without the agency of man, water flows from a rock or soil upon the land or into a body of surface water” (Meinzer, 1923, p. 48).About 450 springs are located on this map. Locations and names are from the U.S. Forest Service maps (1963, 1964) and from topographic maps of the U.S. Geological Survey, both published and in preparation. There is considerable variation in geological occurrence of the springs and in quantity and chemical quality of the water that issues from them. Springs in the Salina quadrangle are more abundant where annual precipitation is 16 inches or more, although there are many springs in arid parts of the quadrangle as well.In the Salina quadrangle, springs are used most commonly for watering livestock. They are used also for irrigation and for domestic and municipal water supply. Several communities in Rabbit Valley, Grass Valley, and Sevier Valley depend on springs for all or part of their water supply.Quantity and quality of water are shown for those few springs for which data are available (Mundorff, 1971). Caution must be used in drinking from springs, especially in arid areas; the water commonly tastes bad and may cause illness.

78 FR 42966 - Advisory Committee for Pharmaceutical Science and Clinical Pharmacology; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001... advisory committee of the Food and Drug Administration (FDA). The meeting will be open to the public. Name..., Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 31, rm. 2417, Silver Spring, MD 20993...

Nickel titanium springs versus stainless steel springs: A randomized clinical trial of two methods of space closure.

PubMed

Norman, Noraina Hafizan; Worthington, Helen; Chadwick, Stephen Mark

2016-09-01

To compare the clinical performance of nickel titanium (NiTi) versus stainless steel (SS) springs during orthodontic space closure. Two-centre parallel group randomized clinical trial. Orthodontic Department University of Manchester Dental Hospital and Orthodontic Department Countess of Chester Hospital, United Kingdom. Forty orthodontic patients requiring fixed appliance treatment were enrolled, each being randomly allocated into either NiTi (n = 19) or SS groups (n = 21). Study models were constructed at the start of the space closure phase (T0) and following the completion of space closure (T1). The rate of space closure achieved for each patient was calculated by taking an average measurement from the tip of the canine to the mesiobuccal groove on the first permanent molar of each quadrant. The study was terminated early due to time constraints. Only 30 patients completed, 15 in each study group. There was no statistically significant difference between the amounts of space closed (mean difference 0.17 mm (95%CI -0.99 to 1.34; P = 0.76)). The mean rate of space closure for NiTi coil springs was 0.58 mm/4 weeks (SD 0.24) and 0.85 mm/4 weeks (SD 0.36) for the stainless steel springs. There was a statistically significant difference between the two groups (P = 0.024), in favour of the stainless steel springs, when the mean values per patient were compared. Our study shows that stainless steel springs are clinically effective; these springs produce as much space closure as their more expensive rivals, the NiTi springs.

14 CFR 23.687 - Spring devices.

Code of Federal Regulations, 2014 CFR

2014-01-01

... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Design and Construction Control Systems § 23.687 Spring devices. The reliability of any spring device used in the control system must be...

14 CFR 23.687 - Spring devices.

Code of Federal Regulations, 2012 CFR

2012-01-01

... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Design and Construction Control Systems § 23.687 Spring devices. The reliability of any spring device used in the control system must be...

14 CFR 23.687 - Spring devices.

Code of Federal Regulations, 2013 CFR

2013-01-01

... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Design and Construction Control Systems § 23.687 Spring devices. The reliability of any spring device used in the control system must be...

14 CFR 23.687 - Spring devices.

Code of Federal Regulations, 2010 CFR

2010-01-01

... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Design and Construction Control Systems § 23.687 Spring devices. The reliability of any spring device used in the control system must be...

14 CFR 23.687 - Spring devices.

Code of Federal Regulations, 2011 CFR

2011-01-01

... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Design and Construction Control Systems § 23.687 Spring devices. The reliability of any spring device used in the control system must be...

Assessment of spring cranioplasty biomechanics in sagittal craniosynostosis patients.

PubMed

Borghi, Alessandro; Schievano, Silvia; Rodriguez Florez, Naiara; McNicholas, Roisin; Rodgers, Will; Ponniah, Allan; James, Greg; Hayward, Richard; Dunaway, David; Jeelani, N U Owase

2017-11-01

OBJECTIVE Scaphocephaly secondary to sagittal craniosynostosis has been treated in recent years with spring-assisted cranioplasty, an innovative approach that leverages the use of metallic spring distractors to reshape the patient skull. In this study, a population of patients who had undergone spring cranioplasty for the correction of scaphocephaly at the Great Ormond Street Hospital for Children was retrospectively analyzed to systematically assess spring biomechanical performance and kinematics in relation to spring model, patient age, and outcomes over time. METHODS Data from 60 patients (49 males, mean age at surgery 5.2 ± 0.9 months) who had received 2 springs for the treatment of isolated sagittal craniosynostosis were analyzed. The opening distance of the springs at the time of insertion and removal was retrieved from the surgical notes and, during the implantation period, from planar radiographs obtained at 1 day postoperatively and at the 3-week follow-up. The force exerted by the spring to the patient skull at each time point was derived after mechanical testing of each spring model-3 devices with the same geometry but different wire thicknesses. Changes in the cephalic index between preoperatively and the 3-week follow-up were recorded. RESULTS Stiffer springs were implanted in older patients (p < 0.05) to achieve the same opening on-table as in younger patients, but this entailed significantly different-higher-forces exerted on the skull when combinations of stiffer springs were used (p < 0.001). After initial force differences between spring models, however, the devices all plateaued. Indeed, regardless of patient age or spring model, after 10 days from insertion, all the devices were open. CONCLUSIONS Results in this study provide biomechanical insights into spring-assisted cranioplasty and could help to improve spring design and follow-up strategy in the future.

Dissolved Free Amino Acids in Hydrothermal Springs at Yellowstone National Park, U.S.A.

NASA Astrophysics Data System (ADS)

Cox, J. S.; Holland, M. E.; Shock, E. L.

2004-12-01

Insights into the organic geochemistry of hydrothermal systems, as well as the dynamics of biotic processes in hot spring ecosystems, can be gained by identifying and quantifying dissolved free amino acids (DFAA). Hydrothermal systems form a unique environmental subset relative to other aqueous settings due to their higher temperatures, largely uncharacterized and exotic microbiology, wider pH range, and elevated levels of rare metals, sulfur, and dissolved gases. Previous studies of hot spring and geothermal systems (e.g. Mukhin et al., 1979; Svensson et al., 2004) indicated the presence of micromolar quantities of various amino acids, but the underlying mechanisms controlling amino acid production and disappearance/consumption have continued to remain elusive. DFAA were identified and quantified in five hot springs at Yellowstone National Park that span a range of pH (2 to 8) and temperature (75 to 93° C/boiling). Biotic uptake experiments and enantiomeric analyses on samples from one location were also performed to elucidate biotic pathways. Analyses were performed using high pressure anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD), which is able to resolve amino acids as well as certain carbohydrates, oligopeptides, and a variety of related biological molecules. Preliminary data indicate that total DFAA concentrations are quite low (sub-micromolar range) and that amino acids with aliphatic and nitrogen-containing R-groups are predominant in the DFAA fraction. The types and concentrations of amino acids were variable across the sites. Obsidian Pool (pH 5.1, 77.5° C), where multiple microbiological studies have been conducted, was found to have a DFAA fraction consisting primarily of glycine with trace amounts of arginine, lysine, and histidine. In comparison, an acidic spring in the Sylvan Springs area (pH 1.9, 79.7° C) had higher total DFAA concentrations and was found to contain primarily arginine, lysine, and leucine, together

Online analysis: Deeper insights into water quality dynamics in spring water.

PubMed

Page, Rebecca M; Besmer, Michael D; Epting, Jannis; Sigrist, Jürg A; Hammes, Frederik; Huggenberger, Peter

2017-12-01

We have studied the dynamics of water quality in three karst springs taking advantage of new technological developments that enable high-resolution measurements of bacterial load (total cell concentration: TCC) as well as online measurements of abiotic parameters. We developed a novel data analysis approach, using self-organizing maps and non-linear projection methods, to approximate the TCC dynamics using the multivariate data sets of abiotic parameter time-series, thus providing a method that could be implemented in an online water quality management system for water suppliers. The (TCC) data, obtained over several months, provided a good basis to study the microbiological dynamics in detail. Alongside the TCC measurements, online abiotic parameter time-series, including spring discharge, turbidity, spectral absorption coefficient at 254nm (SAC254) and electrical conductivity, were obtained. High-density sampling over an extended period of time, i.e. every 45min for 3months, allowed a detailed analysis of the dynamics in karst spring water quality. Substantial increases in both the TCC and the abiotic parameters followed precipitation events in the catchment area. Differences between the parameter fluctuations were only apparent when analyzed at a high temporal scale. Spring discharge was always the first to react to precipitation events in the catchment area. Lag times between the onset of precipitation and a change in discharge varied between 0.2 and 6.7h, depending on the spring and event. TCC mostly reacted second or approximately concurrent with turbidity and SAC254, whereby the fastest observed reaction in the TCC time series occurred after 2.3h. The methodological approach described here enables a better understanding of bacterial dynamics in karst springs, which can be used to estimate risks and management options to avoid contamination of the drinking water. Copyright © 2017 Elsevier B.V. All rights reserved.

Prefrontal NAA and Glx Levels in Different Stages of Psychotic Disorders: a 3T 1H-MRS Study.

PubMed

Liemburg, Edith; Sibeijn-Kuiper, Anita; Bais, Leonie; Pijnenborg, Gerdina; Knegtering, Henderikus; van der Velde, Jorien; Opmeer, Esther; de Vos, Annerieke; Dlabac-De Lange, Jozarni; Wunderink, Lex; Aleman, André

2016-02-23

H-Magnetic Resonance Spectroscopy ((1)H-MRS) can offer insights in various neuropathologies by measuring metabolite levels in the brain. In the current study we investigated the levels of glutamate + glutamine (Glx, neurotransmitter and precursor) and N-Acetyl Aspartate + glutamic acid (NAA + NAAG; neuronal viability) in the prefrontal cortex of patients with a psychotic disorder and people at Ultra High Risk (UHR) for psychosis. A (1)H-MRS spectrum was acquired in 31 patients with a recent onset psychotic disorder and 60 with a chronic state, 16 UHR patients and 36 healthy controls. Absolute metabolite levels were calculated using LCModel with a reference water peak. Groups were compared while taking into account age and partial volume effects. Moreover, we investigated associations with positive and negative symptoms, duration of illness, and antipsychotic treatment in patients. The most notable finding is that chronicity of schizophrenia was related to decreased levels of Glx and NAA. On the other hand, although on an exploratory note, UHR showed increased levels of prefrontal Glx and NAA levels with increasing age. Our results may indicate an initial Glx and NAA increase and subsequent decrease during illness progression that may be related to the neurotoxic effects of glutamate.

Fractures and stresses in Bone Spring sandstones. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Warpinski, N.R.; Sattler, A.R.; Lorenz, J.C.

This project was a collaboration between Sandia National Laboratories and the Harvey E. Yates Company (Heyco), Roswell, NM, conducted under the auspices of Department of Energy`s Oil Recovery Technology Partnership. The project applied Sandia perspectives on the effects of natural fractures, stress, and sedimentology for the stimulation and production of low permeability gas reservoirs to low permeability oil reservoirs, such as those typified by the Bone Spring sandstones of the Delaware Basin, southeast New Mexico. This report details the results and analyses obtained in 1990 from core, logs, stress, and other data taken from three additional development wells. An overallmore » summary gives results from all five wells studied in this project in 1989--1990. Most of the results presented are believed to be new information for the Bone Spring sandstones.« less

37. Historic American Buildings Survey E. W. Russell, Photographer, May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

37. Historic American Buildings Survey E. W. Russell, Photographer, May 7, 1936 ROTUNDA, 3rd FLOOR, SHOWING E. HALL BETWEEN ROOMS ON N. AND E. - Spring Hill College, Main Building, Old Shell Road, Spring Hill, Mobile County, AL

Experimenting with Inexpensive Plastic Springs

ERIC Educational Resources Information Center

Perez, Leander; Marques, Adriana; Sánchez, Iván

2014-01-01

Acommon undergraduate laboratory experience is the determination of the elastic constant of a spring, whether studying the elongation under a static load or studying the damped harmonic motion of the spring with a suspended mass. An alternative approach to this laboratory experience has been suggested by Menezes et al., aimed at studying the…

Water quality modelling of Jadro spring.

PubMed

Margeta, J; Fistanic, I

2004-01-01

Management of water quality in karst is a specific problem. Water generally moves very fast by infiltration processes but far more by concentrated flows through fissures and openings in karst. This enables the entire surface pollution to be transferred fast and without filtration into groundwater springs. A typical example is the Jadro spring. Changes in water quality at the spring are sudden, but short. Turbidity as a major water quality problem for the karst springs regularly exceeds allowable standards. Former practice in problem solving has been reduced to intensive water disinfection in periods of great turbidity without analyses of disinfection by-products risks for water users. The main prerequisite for water quality control and an optimization of water disinfection is the knowledge of raw water quality and nature of occurrence. The analysis of monitoring data and their functional relationship with hydrological parameters enables establishment of a stochastic model that will help obtain better information on turbidity in different periods of the year. Using the model a great number of average monthly and extreme daily values are generated. By statistical analyses of these data possibility of occurrence of high turbidity in certain months is obtained. This information can be used for designing expert system for water quality management of karst springs. Thus, the time series model becomes a valuable tool in management of drinking water quality of the Jadro spring.

Focal changes in brain energy and phospholipid metabolism in first-episode schizophrenia: 31P-MRS chemical shift imaging study at 4 Tesla.

PubMed

Jensen, J Eric; Miller, Jodi; Williamson, Peter C; Neufeld, Richard W J; Menon, Ravi S; Malla, Ashok; Manchanda, Rahul; Schaefer, Betsy; Densmore, Maria; Drost, Dick J

2004-05-01

Membrane phospholipid and high-energy abnormalities measured with phosphorus magnetic resonance spectroscopy ((31)P-MRS) have been reported in patients with schizophrenia in several brain regions. Using improved imaging techniques, previously inaccessible brain regions were examined in patients with first-episode schizophrenia and healthy volunteers with 4.0 T (31)P-MRS. Brain spectra were collected in vivo from 15 patients with first-episode schizophrenia and 15 healthy volunteers from 15 cm(3) effective voxels in the thalamus, cerebellum, hippocampus, anterior/posterior cingulate, prefrontal cortex and parieto-occipital cortex. People with first-episode schizophrenia showed increased levels of glycerophosphocholine in the anterior cingulate. Inorganic phosphate, phosphocreatine and adenosine triphosphate concentrations were also increased in the anterior cingulate in this group. The increased phosphodiester and high-energy phosphate levels in the anterior cingulate of brains of people with first-episode schizophrenia may indicate neural overactivity in this region during the early stages of the illness, resulting in increased excitotoxic neural membrane breakdown.

Adapting a rapid assessment protocol to environmentally assess palm swamp (Veredas) springs in the Cerrado biome, Brazil.

PubMed

Guimarães, Ariane; de Lima Rodrigues, Aline Sueli; Malafaia, Guilherme

2017-10-30

The exploitation and degradation of natural environments exert intense pressure on important ecosystems worldwide. Thus, it is necessary developing or adapting assessment methods to monitor environmental changes and to generate results to be applied to environmental management programs. The Brazilian Veredas (phytophysiognomies typical to the Cerrado biome) are threatened by several human activities; thus, the aim of the present study is to adapt a rapid assessment protocol (RAP) to be applied to Veredas springs, by using the upper course of the Vai-e-Vem stream watershed (Ipameri County, Goiás State, Brazil). Therefore, several springs in the study site were visited and 11 of them were considered Veredas springs. After the RAP was adapted, the instrument was validated and used to environmentally assess the springs in order to demonstrate its applicability. The present study has provided an instrument of option to monitor Veredas springs.

Dissolved oxygen fluctuations in karst spring flow and implications for endemic species: Barton Springs, Edwards aquifer, Texas, USA

USGS Publications Warehouse

Mahler, Barbara J.; Bourgeais, Renan

2013-01-01

Karst aquifers and springs provide the dissolved oxygen critical for survival of endemic stygophiles worldwide, but little is known about fluctuations of dissolved oxygen concentrations (DO) and factors that control those concentrations. We investigated temporal variation in DO at Barton Springs, Austin, Texas, USA. During 2006–2012, DO fluctuated by as much as a factor of 2, and at some periods decreased to concentrations that adversely affect the Barton Springs salamander (Eurycea sorosum) (≤4.4 mg/L), a federally listed endangered species endemic to Barton Springs. DO was lowest (≤4.4 mg/L) when discharge was low (≤1 m3/s) and spring water temperature was >21 °C, although not at a maximum; the minimum DO recorded was 4.0 mg/L. Relatively low DO (3/s) and maximum T (22.2 °C). A four-segment linear regression model with daily data for discharge and spring water temperature as explanatory variables provided an excellent fit for mean daily DO (Nash–Sutcliffe coefficient for the validation period of 0.90). DO also fluctuated at short-term timescales in response to storms, and DO measured at 15-min intervals could be simulated with a combination of discharge, spring temperature, and specific conductance as explanatory variables. On the basis of the daily-data regression model, we hypothesize that more frequent low DO corresponding to salamander mortality could result from (i) lower discharge from Barton Springs resulting from increased groundwater withdrawals or decreased recharge as a result of climate change, and (or) (ii) higher groundwater temperature as a result of climate change.

Classic cases revisited: Mrs Janet Tracey, resuscitation and the importance of good communication.

PubMed

Szawarski, Piotr

2015-05-01

The prevalence of inappropriate care, defined as actions contrary to personal and professional beliefs, is high. This is a reflection of the reluctance of the society at large to acknowledge the biological certainty that is death. The case of Mrs Janet Tracey illustrates importance of good communication at the end of life, and the difficulties associated with making of DNACPR decisions. The case brings together two bioethical perspectives on the relationship between the patient and the physician namely the rights based approach, as emphasised by the Article 8 of the European Convention on Human Rights and the bioethical principles approach ephasising autonomy. In doing so it creates a medico-legal landmark for all those involved in management of the end of life.

Juvenile Spring Eruption: A Variant of Perniosis?

PubMed

Nabatian, Adam S; Rosman, Ilana S; Sturza, Jeffrey; Jacobson, Mark

2015-09-01

Juvenile spring eruption (JSE) is a unique condition that typically affects the helices of the ears of boys and young men. The classical clinical picture of JSE includes the abrupt onset of lesions after spending time outdoors in the early spring. Because of the papulovesicular nature of the rash and the history of sun exposure, JSE is considered a variant of polymorphous light eruption. In addition to the term "juvenile spring eruption," this entity has also been described under other less common terms such as "perniosis juvenilis vernalis aurium" or "spring perniosis," which emphasizes the onset in the spring and the possible pathogenic role of cold weather. We present a case of likely JSE with histopathologic features more consistent with perniosis than polymorphous light eruption and present a review the literature.

Armored spring-core superconducting cable and method of construction

DOEpatents

McIntyre, Peter M.; Soika, Rainer H.

2002-01-01

An armored spring-core superconducting cable (12) is provided. The armored spring-core superconducting cable (12) may include a spring-core (20), at least one superconducting strand (24) wound onto the spring-core (20), and an armored shell (22) that encases the superconducting strands (24). The spring-core (20) is generally a perforated tube that allows purge gases and cryogenic liquids to be circulated through the armored superconducting cable (12), as well as managing the internal stresses within the armored spring-core superconducting cable (12). The armored shell (22) manages the external stresses of the armored spring-core superconducting cable (12) to protect the fragile superconducting strands (24). The armored spring-core superconducting cable (12) may also include a conductive jacket (34) formed outwardly of the armored shell (22).

Microbial Source Tracking in Adjacent Karst Springs.

PubMed

Ohad, Shoshanit; Vaizel-Ohayon, Dalit; Rom, Meir; Guttman, Joseph; Berger, Diego; Kravitz, Valeria; Pilo, Shlomo; Huberman, Zohar; Kashi, Yechezkel; Rorman, Efrat

2015-08-01

Modern man-made environments, including urban, agricultural, and industrial environments, have complex ecological interactions among themselves and with the natural surroundings. Microbial source tracking (MST) offers advanced tools to resolve the host source of fecal contamination beyond indicator monitoring. This study was intended to assess karst spring susceptibilities to different fecal sources using MST quantitative PCR (qPCR) assays targeting human, bovine, and swine markers. It involved a dual-time monitoring frame: (i) monthly throughout the calendar year and (ii) daily during a rainfall event. Data integration was taken from both monthly and daily MST profile monitoring and improved identification of spring susceptibility to host fecal contamination; three springs located in close geographic proximity revealed different MST profiles. The Giach spring showed moderate fluctuations of MST marker quantities amid wet and dry samplings, while the Zuf spring had the highest rise of the GenBac3 marker during the wet event, which was mirrored in other markers as well. The revelation of human fecal contamination during the dry season not connected to incidents of raining leachates suggests a continuous and direct exposure to septic systems. Pigpens were identified in the watersheds of Zuf, Shefa, and Giach springs and on the border of the Gaaton spring watershed. Their impact was correlated with partial detection of the Pig-2-Bac marker in Gaaton spring, which was lower than detection levels in all three of the other springs. Ruminant and swine markers were detected intermittently, and their contamination potential during the wet samplings was exposed. These results emphasized the importance of sampling design to utilize the MST approach to delineate subtleties of fecal contamination in the environment. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Sources of antibiotics: Hot springs.

PubMed

Mahajan, Girish B; Balachandran, Lakshmi

2017-06-15

The discovery of antibiotics heralded an era of improved health care. However, the over-prescription and misuse of antibiotics resulted in the development of resistant strains of various pathogens. Since then, there has been an incessant search for discovering novel compounds from bacteria at various locations with extreme conditions. The soil is one of the most explored locations for bioprospecting. In recent times, hypersaline environments and symbiotic associations have been investigated for novel antimicrobial compounds. Among the extreme environments, hot springs are comparatively less explored. Many researchers have reported the presence of microbial life and secretion of antimicrobial compounds by microorganisms in hot springs. A pioneering research in the corresponding author's laboratory resulted in the identification of the antibiotic Fusaricidin B isolated from a hot spring derived eubacteria, Paenibacillus polymyxa, which has been assigned a new application for its anti-tubercular properties. The corresponding author has also reported anti-MRSA and anti-VRE activity of 73 bacterial isolates from hot springs in India. Copyright © 2016 Elsevier Inc. All rights reserved.

Spring weather conditions influence breeding phenology and reproductive success in sympatric bat populations.

PubMed

Linton, Danielle M; Macdonald, David W

2018-04-10

Climate is known to influence breeding phenology and reproductive success in temperate-zone bats, but long-term population level studies and interspecific comparisons are rare. Investigating the extent to which intrinsic (i.e. age), and extrinsic (i.e. spring weather conditions), factors influence such key demographic parameters as the proportion of females becoming pregnant, or completing lactation, each breeding season, is vital to understanding of bat population ecology and life-history traits. Using data from 12 breeding seasons (2006-2017), encompassing the reproductive histories of 623 Myotis daubentonii and 436 Myotis nattereri adult females, we compare rates of recruitment to the breeding population and show that these species differ in their relative sensitivity to environmental conditions and climatic variation, affecting annual reproductive success at the population level. We demonstrate that (1) spring weather conditions influence breeding phenology, with warm, dry and calm conditions leading to earlier parturition dates and advanced juvenile development, whilst cold, wet and windy weather delays birth timing and juvenile growth; (2) reproductive rates in first-year females are influenced by spring weather conditions in that breeding season and in the preceding breeding season when each cohort was born. Pregnancy and lactation rates were both higher when favourable spring foraging conditions were more prevalent; (3) reproductive success increases with age in both species, but at different rates; (4) reproductive rates were consistently higher, and showed less interannual variation, in second-year and older M. daubentonii (mean 91.55% ± 0.05 SD) than M. nattereri (mean 72.74% ± 0.15 SD); (5) estimates of reproductive success at the population level were highly correlated with the size of the juvenile cohort recorded each breeding season. Improving understanding of the influence of environmental conditions, especially extreme climatic

75 FR 56114 - Advisory Committee on Interdisciplinary, Community-Based Linkages; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-15

...: September 22, 2010, 11 a.m. to 3 p.m., EDT. Place: Conference Call. Status: The meeting will be open to the... Interprofessional Workforce to Manage Health Behaviors. The Committee proposes to discuss a concept paper with its... includes a presentation by Dr. Bonnie Spring, author of the concept paper that will be included in the...

49 CFR 213.139 - Spring rail frogs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Spring rail frogs. 213.139 Section 213.139..., DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Structure § 213.139 Spring rail frogs. (a) The outer edge of a wheel tread shall not contact the gage side of a spring wing rail. (b) The toe of each...

49 CFR 213.139 - Spring rail frogs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Spring rail frogs. 213.139 Section 213.139..., DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Structure § 213.139 Spring rail frogs. (a) The outer edge of a wheel tread shall not contact the gage side of a spring wing rail. (b) The toe of each...

49 CFR 213.139 - Spring rail frogs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Spring rail frogs. 213.139 Section 213.139..., DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Structure § 213.139 Spring rail frogs. (a) The outer edge of a wheel tread shall not contact the gage side of a spring wing rail. (b) The toe of each...

49 CFR 213.139 - Spring rail frogs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Spring rail frogs. 213.139 Section 213.139..., DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Structure § 213.139 Spring rail frogs. (a) The outer edge of a wheel tread shall not contact the gage side of a spring wing rail. (b) The toe of each...

49 CFR 213.139 - Spring rail frogs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Spring rail frogs. 213.139 Section 213.139..., DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Structure § 213.139 Spring rail frogs. (a) The outer edge of a wheel tread shall not contact the gage side of a spring wing rail. (b) The toe of each...

To Mrs. Roosevelt, Who "Looks for the Poor" and to FDR: The CCC Is "A Vain Effort to Placate Youth." Teaching Ideas.

ERIC Educational Resources Information Center

Cohen, Robert

1996-01-01

Utilizes letters to the First Lady and President Roosevelt as primary sources for a series of activities supporting a unit on the Great Depression. The letter to Mrs. Roosevelt asks for some old clothes for a needy family. The letter to President Roosevelt expresses dissatisfaction with his efforts. (MJP)

78 FR 76177 - Sunshine Act Meeting Notice; Change of Time of Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-16

... INTERNATIONAL TRADE COMMISSION [USITC SE-13-036] Sunshine Act Meeting Notice; Change of Time of Sunshine Act Meeting AGENCY HOLDING THE MEETING: United States International Trade Commission. DATE: December 13, 2013. NEW TIME: 9:30 a.m. PLACE: Room 101, 500 E Street SW., Washington, DC 20436, Telephone...

(1)H-MRS in glutaric aciduria type 1: impact of biochemical phenotype and age on the cerebral accumulation of neurotoxic metabolites.

PubMed

Harting, Inga; Boy, Nikolas; Heringer, Jana; Seitz, Angelika; Bendszus, Martin; Pouwels, Petra J W; Kölker, Stefan

2015-09-01

In glutaric aciduria type 1 (GA1) the neurotoxic metabolites glutaric acid (GA) and 3-hydroxyglutaric acid (3-OH-GA) accumulate within the brain. Due to limited efflux across the blood-brain-barrier biochemical monitoring of intracerebrally accumulating toxic metabolites is as yet not possible. To investigate brain metabolic patterns in glutaric aciduria type 1 using (1)H magnetic resonance spectroscopy ((1)H-MRS) with focus on detecting the disease-related neurotoxic metabolites GA and 3-OH-GA. Short echo time (1)H-MRS was performed in 13 treated metabolically stable patients. Twenty-one white matter and 16 basal ganglia spectra from 12 patients (age range 7 months - 22 years) were included. Subgroups based on age, biochemical phenotype and/or associated MRI changes were compared with control spectra. GA was elevated in white matter of patients. 3-OH-GA was elevated in white matter of older patients with associated signal changes on MRI, which was structurally characterized by decreased creatine and phosphocreatine (tCr) and elevated choline (Cho). Metabolite changes differed with biochemical phenotype and disease duration: Low excretors with up to 30% residual enzyme activity had only mildly, non-significantly elevated GA and mildly subnormal N-acetylaspartate (tNAA). High excretors with complete lack of enzyme activity had significantly increased GA, tNAA was mildly subnormal in younger and decreased in older high excretors. GA and 3-OH-GA are detectable by in vivo (1)H-MRS, which might finally allow biochemical follow-up monitoring of intracerebrally accumulating neurotoxic metabolites in GA1. A high excreting phenotype appears to be a risk factor for cerebral GA accumulation and progressive neuroaxonal compromise despite a similar clinical course in younger high and low excreting patients. This might have consequences for long-term outcome.

Amino acid metabolic processes in the temporal lobes assessed by proton magnetic resonance spectroscopy (1H MRS) in children with Down syndrome.

PubMed

Śmigielska-Kuzia, Joanna; Boćkowski, Leszek; Sobaniec, Wojciech; Kułak, Wojciech; Sendrowski, Krzysztof

2010-01-01

Down syndrome (DS), or trisomy 21, is one of the most common autosomal mutations. The overexpression of the β-amyloid precursor protein gene, located on chromosome 21, causes an increased production of the specific amyloid. The current study is a continuation of our earlier investigations relating to the profile of metabolic changes in the frontal lobes of DS patients as assessed by proton magnetic resonance spectroscopy ((1)H MRS). The aims of the study were the morphological assessment of the brain using magnetic resonance imaging (MRI) and the evaluation of metabolic disorders of the temporal lobes using (1)H MRS in DS children. The study group included 20 children with DS aged 3-15 years and treated in the Department of Pediatric Neurology and Rehabilitation, Medical University of Białystok. The control group included healthy children (n = 20). MRI scans of the heads of DS children were performed using a 1.5 T MR scanner under standard conditions. (1)H MRS investigations were also carried out to assess metabolic changes in the temporal lobes. Metabolites, such as N-acetylaspartate (NAA), glutamate-glutamine complex (Glx), choline (Cho), myoinositol (mI) and γ-aminobutyric acid (GABA), were determined in both temporal lobes with reference to the internal marker creatine (Cr). Results were compared with the control group.We found a statistically significant decrease in NAA/Cr, Cho/Cr, mI/Cr and GABA/Cr ratios. The Glx/Cr ratio in both temporal lobes of DS patients did not differ from the control group. Our results indicate metabolic neurotransmitter disorders in the central nervous system in children with DS.

Escapement and Productivity of Spring Chinook Salmon and Summer Steelhead in the John Day River Basin, 2005-2006 Annual Technical Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schultz, Terra Lang; Wilson, Wayne H.; Ruzycki, James R.

The objectives are: (1) Estimate number and distribution of spring Chinook salmon Oncorhynchus tshawytscha redds and spawners in the John Day River subbasin; and (2) Estimate smolt-to-adult survival rates (SAR) and out-migrant abundance for spring Chinook and summer steelhead O. mykiss and life history characteristics of summer steelhead. The John Day River subbasin supports one of the last remaining intact wild populations of spring Chinook salmon and summer steelhead in the Columbia River Basin. These populations, however, remain depressed relative to historic levels. Between the completion of the life history and natural escapement study in 1984 and the start ofmore » this project in 1998, spring Chinook spawning surveys did not provide adequate information to assess age structure, progeny-to-parent production values, smolt-to-adult survival (SAR), or natural spawning escapement. Further, only very limited information is available for steelhead life history, escapement, and productivity measures in the John Day subbasin. Numerous habitat protection and rehabilitation projects to improve salmonid freshwater production and survival have also been implemented in the basin and are in need of effectiveness monitoring. While our monitoring efforts outlined here will not specifically measure the effectiveness of any particular project, they will provide much needed background information for developing context for project-specific effectiveness monitoring efforts. To meet the data needs as index stocks, to assess the long-term effectiveness of habitat projects, and to differentiate freshwater and ocean survival, sufficient annual estimates of spawner escapement, age structure, SAR, egg-to-smolt survival, smolt-per-redd ratio, and freshwater habitat use are essential. We have begun to meet this need through spawning ground surveys initiated for spring Chinook salmon in 1998 and smolt PIT-tagging efforts initiated in 1999. Additional sampling and analyses to meet these

Phenological changes in bamboo carbohydrates explain the preference for culm over leaves by giant pandas (Ailuropoda melanoleuca) during spring

PubMed Central

Knott, Katrina K.; Christian, Amelia L.; Falcone, Josephine F.; Vance, Carrie K.; Bauer, Laura L.; Fahey, George C.; Kouba, Andrew J.

2017-01-01

Seasonal changes in the foodscape force herbivores to select different plant species or plant parts to meet nutritional requirements. We examined whether the search for calorie-rich carbohydrates explained giant panda’s selection for bamboo culm over leaves during spring. Leaves and culms were collected from four Phyllostachys bamboos (P. aurea, P. aureosulcata, P. glauca, and P. nuda) once per month over 18–27 months. Monthly changes in annual plant part nutrients were examined, and compared to seasonal foraging behaviors of captive giant pandas. Although total fiber was greater (p<0.0001) in culm (85.6 ± 0.5%) than leaves (55.3 ± 0.4%) throughout the year, culm fiber was at its lowest in spring (79–85%) when culm selection by giant pandas exceeded 70% of their overall diet. Culm starch also was greatest (p = 0.044) during spring (5.5 ± 1.1%) and 2.5-fold the percentage of starch in leaves (2.2 ± 0.6%). The free sugars in spring culm consisted of a high proportion of glucose (35%) and fructose (47%), whereas sucrose made up 42% of the total free sugar content of spring leaves. Bound sugars in culm consisted of 60% glucose and 38% xylose likely representative of hemicellulose. The concentrations of bound sugars (hemicelluloses) in spring culms (543.7 ± 13.0 mg/g) was greater (p<0.001) than in leaves (373.0 ± 14.8 mg/g). These data help explain a long-standing question in giant panda foraging ecology: why consume the plant part with the lowest protein and fat during the energetically intensive spring breeding season? Giant pandas likely prefer spring culm that contains abundant mono- and polysaccharides made more bioavailable as a result of reduced fiber content. These data suggest that phenological changes in bamboo plant part nutrition drive foraging decisions by giant pandas. PMID:28614359

Increasing the resource of high load compression springs

NASA Astrophysics Data System (ADS)

Zemlyanushnova, N. Y.; Zemlyanushnov, N. A.

2017-10-01

Valve springs of VAZ automobiles’ engines are manufactured by using a new method. The decrease of dispersion of operating load in experimental springs compared to serial ones has been proved. The springs have passed a stress cycling test. With the new method having been used, it has been proved that the resource of high load springs working at high loading speed with coils collision has increased up to 60%.

Hydrogeology and ground-water-flow simulation of the Cave Springs area, Hixson, Tennessee

USGS Publications Warehouse

Haugh, Connor J.

2002-01-01

The ground-water resource in the Cave Springs area is used by the Hixson Utility District as a water supply and is one of the more heavily stressed in the Valley and Ridge Physiographic Province. In 1999, ground-water withdrawals by the Hixson Utility District averaged about 6.4 million gallons per day (Mgal/d) from two pumping centers. The Hixson Utility District has historically withdrawn about 5.8 Mgal/d from wells at Cave Springs. In 1995 to meet increasing demand, an additional well field was developed at Walkers Corner, located about 3 miles northeast of Cave Springs. From 1995 through 2000, pumping from the first production well at Walkers Corner averaged about 1.8 Mgal/d. A second production well at Walkers Corner was approved for use in 2000. Hixson Utility District alternates the use of the two production wells at Walkers Corner except when drought conditions occur when they are used simultaneously. The second production well increased the capacity of the well field by an additional 2 Mgal/d. The aquifer framework in the study area consists of dense Paleozoic carbonate rocks with secondary permeability that are mantled by thick residual clay-rich regolith in most of the area and by coarse-grained alluvium in the valley of North Chickamauga Creek. Cave Springs, one of the largest springs in Tennessee, derives its flow from conduits in a carbonate rock (karst) aquifer. Production wells at Cave Springs draw water from these conduits. Production wells at Walkers Corner primarily draw water from gravel zones in the regolith near the top of rock. Transmissivities estimated from hydraulic tests conducted across the Cave Springs area span a range from 240 to 900,000 feet squared per day (ft2/d) with a median value of 5,200 ft2/d. Recharge to the aquifer occurs from direct infiltration of precipitation and from losing streams. Most recharge occurs during the winter and spring months. Computer modeling was used to provide a better understanding of the ground

Integrated geophysical investigations of Main Barton Springs, Austin, Texas, USA

NASA Astrophysics Data System (ADS)

Saribudak, By Mustafa; Hauwert, Nico M.

2017-03-01

Barton Springs is a major discharge site for the Barton Springs Segment of the Edwards Aquifer and is located in Zilker Park, Austin, Texas. Barton Springs actually consists of at least four springs. The Main Barton Springs discharges into the Barton Springs pool from the Barton Springs fault and several outlets along a fault, from a cave, several fissures, and gravel-filled solution cavities on the floor of the pool west of the fault. Surface geophysical surveys [resistivity imaging, induced polarization (IP), self-potential (SP), seismic refraction, and ground penetrating radar (GPR)] were performed across the Barton Springs fault and at the vicinity of the Main Barton Springs in south Zilker Park. The purpose of the surveys was two-fold: 1) locate the precise location of submerged conduits (caves, voids) carrying flow to Main Barton Springs; and 2) characterize the geophysical signatures of the fault crossing Barton Springs pool. Geophysical results indicate significant anomalies to the south of the Barton Springs pool. A majority of these anomalies indicate a fault-like pattern, in front of the south entrance to the swimming pool. In addition, resistivity and SP results, in particular, suggest the presence of a large conduit in the southern part of Barton Springs pool. The groundwater flow-path to the Main Barton Springs could follow the locations of those resistivity and SP anomalies along the newly discovered fault, instead of along the Barton Springs fault, as previously thought.

Pioneering Techniques to Determine Wastewater and Urban Runoff Loads in Karst Spring Systems

NASA Astrophysics Data System (ADS)

Hasenmueller, E. A.; Criss, R. E.

2010-12-01

Comparison of urban and rural springs quantifies the magnitude and sources of water quality degradation in east-central Missouri. Urban springs consistently display a suite of impairment characteristics including increases in: (1) specific conductance; (2) coliform bacteria; (3) total suspended solids (TSS); (4) nutrient concentrations including N, P, and S species; (5) B concentration; (6) heavy metal concentrations such as Cd, Cr, and Pb; and (7) temperature variability. Several dozen springs, representing a range in magnitude and recharge area land use, were sampled in and around St. Louis, MO. In addition, effluent from the Duckett Creek Treatment Plant was sampled to ascertain the chemistry of municipal waste waters in the area. Sodium perborate is a primary ingredient in bleaching agents for detergents, and therefore B is found in very high concentrations in waste waters (> 240 ppb) compared to background levels (< 20 ppb) in carbonate-hosted springs. Consequently, B provides an excellent, conservative tracer of sewage contributions to groundwater systems, and this study has shown that several urban springs comprise > 25% waste water. High B concentrations correlate well with increased nutrient contents and high E. coli and total coliform levels, which also suggest large sewage contributions to the shallow groundwater. Elevated specific conductance in these springs is primarily due to road salt contamination of these Ca-Mg-bicarbonate waters. In marked contrast to natural springs, Na and Cl can even be the dominant ions in urban springs, so they are useful indicators of urban runoff. High concentrations of Na and Cl ions persist well into late summer, confirming stable isotope models for the ~ 1 year residence time of these shallow groundwaters. Further, specific conductance, temperature, and TSS are highly variable in urban springs because of amplified throughput of storm water runoff; in fact, many detention basins directly feed into cave systems. Dissolved

Portrait of a Geothermal Spring, Hunter’s Hot Springs, Oregon

PubMed Central

Castenholz, Richard W.

2015-01-01

Although alkaline Hunter’s Hot Springs in southeastern Oregon has been studied extensively for over 40 years, most of these studies and the subsequent publications were before the advent of molecular methods. However, there are many field observations and laboratory experiments that reveal the major aspects of the phototrophic species composition within various physical and chemical gradients of these springs. Relatively constant temperature boundaries demark the upper boundary of the unicellular cyanobacterium, Synechococcus at 73–74 °C (the world-wide upper limit for photosynthesis), and 68–70 °C the upper limit for Chloroflexus. The upper limit for the cover of the filamentous cyanobacterium, Geitlerinema (Oscillatoria) is at 54–55 °C, and the in situ lower limit at 47–48 °C for all three of these phototrophs due to the upper temperature limit for the grazing ostracod, Thermopsis. The in situ upper limit for the cyanobacteria Pleurocapsa and Calothrix is at ~47–48 °C, which are more grazer-resistant and grazer dependent. All of these demarcations are easily visible in the field. In addition, there is a biosulfide production in some sections of the springs that have a large impact on the microbiology. Most of the temperature and chemical limits have been explained by field and laboratory experiments. PMID:25633225

Durability of the beneficial effect of MLC601 (NeuroAiD™) on functional recovery among stroke patients from the Philippines in the CHIMES and CHIMES-E studies.

PubMed

Navarro, Jose C; Chen, Christopher Lh; Lee, Chun F; Gan, Herminigildo H; Lao, Annabelle Y; Baroque, Alejandro C; Hiyadan, John Harold B; Chua, Carlos L; San Jose, Ma Cristina; Advincula, Joel M; Venketasubramanian, Narayanaswamy

2017-04-01

Background and Aim A pre-specified country analysis of subjects from the Philippines in the CHInese Medicine NeuroAiD Efficacy on Stroke recovery (CHIMES) Study showed significantly improved functional and neurological outcomes on MLC601 at month (M) 3. We aimed to assess these effects on long-term functional recovery in the Filipino cohort. Methods The CHIMES-E (extension) Study evaluated subjects who completed three months of randomized placebo-controlled treatment in CHIMES up to two years. Blinding of treatment allocation was maintained and all subjects received standard stroke care and rehabilitation. Modified Rankin Score (mRS) and Barthel Index (BI) were assessed in-person at M3 and by telephone at M6, M12, M18, M24. Odds ratios (OR) with corresponding 95% confidence intervals (CI) for functional recovery using ordinal analysis of mRS and for achieving functional independence (mRS 0-1 or BI ≥ 95) at each time point were calculated, adjusting for age, sex, baseline National Institute of Health Stroke Scale (NIHSS), onset-to-treatment time (OTT) and pre-stroke mRS. Results The 378 subjects (MLC601 192, placebo 186) included in CHIMES-E from the Philippines (mean age 60.2 ± 11.1) had more women ( p < 0.001), worse baseline NIHSS ( p < 0.001) and longer onset to treatment time ( p = 0.002) compared to other countries. Baseline characteristics were similar between treatment groups. The treatment effect of MLC601 seen at M3 peaked at M6 with OR for mRS shift of 1.53 (95% CI 1.05-2.22), mRS dichotomy 0-1 of 1.77 (95% CI 1.10-2.83), and BI ≥ 95 of 1.87 (95% CI 1.16-3.02). The beneficial effect persisted up to M24. Conclusion The beneficial effect of MLC601 seen at M3 in the Filipino cohort is durable up to two years after stroke.

Biogeographic congruency among bacterial communities from terrestrial sulfidic springs

PubMed Central

Headd, Brendan; Engel, Annette S.

2014-01-01

Terrestrial sulfidic springs support diverse microbial communities by serving as stable conduits for geochemically diverse and nutrient-rich subsurface waters. Microorganisms that colonize terrestrial springs likely originate from groundwater, but may also be sourced from the surface. As such, the biogeographic distribution of microbial communities inhabiting sulfidic springs should be controlled by a combination of spring geochemistry and surface and subsurface transport mechanisms, and not necessarily geographic proximity to other springs. We examined the bacterial diversity of seven springs to test the hypothesis that occurrence of taxonomically similar microbes, important to the sulfur cycle, at each spring is controlled by geochemistry. Complementary Sanger sequencing and 454 pyrosequencing of 16S rRNA genes retrieved five proteobacterial classes, and Bacteroidetes, Chlorobi, Chloroflexi, and Firmicutes phyla from all springs, which suggested the potential for a core sulfidic spring microbiome. Among the putative sulfide-oxidizing groups (Epsilonproteobacteria and Gammaproteobacteria), up to 83% of the sequences from geochemically similar springs clustered together. Abundant populations of Hydrogenimonas-like or Sulfurovum-like spp. (Epsilonproteobacteria) occurred with abundant Thiothrix and Thiofaba spp. (Gammaproteobacteria), but Arcobacter-like and Sulfurimonas spp. (Epsilonproteobacteria) occurred with less abundant gammaproteobacterial populations. These distribution patterns confirmed that geochemistry rather than biogeography regulates bacterial dominance at each spring. Potential biogeographic controls were related to paleogeologic sedimentation patterns that could control long-term microbial transport mechanisms that link surface and subsurface environments. Knowing the composition of a core sulfidic spring microbial community could provide a way to monitor diversity changes if a system is threatened by anthropogenic processes or climate change. PMID

Fabrication and modeling of shape memory alloy springs

NASA Astrophysics Data System (ADS)

Heidari, B.; Kadkhodaei, M.; Barati, M.; Karimzadeh, F.

2016-12-01

In this paper, shape memory alloy (SMA) helical springs are produced by shape setting two sets of NiTi (Ti-55.87 at% Ni) wires, one of which showing shape memory effect and another one showing pseudoelasticity at the ambient temperature. Different pitches as well as annealing temperatures are tried to investigate the effect of such parameters on the thermomechanical characteristics of the fabricated springs. Phase transformation temperatures of the products are measured by differential scanning calorimetry and are compared with those of the original wires. Compression tests are also carried out, and stiffness of each spring is determined. The desired pitches are so that a group of springs experiences phase transition during loading while the other does not. The former shows a varying stiffness upon the application of compression, but the latter acts as passive springs with a predetermined stiffness. Based on the von-Mises effective stress and strain, an enhanced one-dimensional constitutive model is further proposed to describe the shear stress-strain response within the coils of an SMA spring. The theoretically predicted force-displacement responses of the produced springs are shown to be in a reasonable agreement with the experimental results. Finally, effects of variations in geometric parameters on the axial force-displacement response of an SMA spring are investigated.

Scalability of an endoluminal spring for distraction enterogenesis.

PubMed

Rouch, Joshua D; Huynh, Nhan; Scott, Andrew; Chiang, Elvin; Wu, Benjamin M; Shekherdimian, Shant; Dunn, James C Y

2016-12-01

Techniques of distraction enterogenesis have been explored to provide increased intestinal length to treat short bowel syndrome (SBS). Self-expanding, polycaprolactone (PCL) springs have been shown to lengthen bowel in small animal models. Their feasibility in larger animal models is a critical step before clinical use. Juvenile mini-Yucatan pigs underwent jejunal isolation or blind ending Roux-en-y jejunojejunostomy with insertion of either a PCL spring or a sham PCL tube. Extrapolated from our spring characteristics in rodents, proportional increases in spring constant and size were made for porcine intestine. Jejunal segments with 7mm springs with k between 9 and 15N/m demonstrated significantly increased lengthening in isolated segment and Roux-en-y models. Complications were noted in only two animals, both using high spring constant k>17N/m. Histologically, lengthened segments in the isolated and Roux models demonstrated significantly increased muscularis thickness and crypt depth. Restoration of lengthened, isolated segments back into continuity was technically feasible after 6weeks. Self-expanding, endoluminal PCL springs, which exert up to 0.6N force, safely achieve significant intestinal lengthening in a translatable, large-animal model. These spring characteristics may provide a scalable model for the treatment of SBS in children. Copyright © 2016 Elsevier Inc. All rights reserved.

Summary of Needs and Opportunities from the 2011 Residential Energy Efficiency Stakeholders Meeting: Atlanta, Georgia -- March 16-18, 2011

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This summary report outlines needs and issues for increasing energy efficiency of new and existing U.S homes, as identified at the U.S Department of Energy Building America program Spring 2011 stakeholder meeting in Atlanta, Georgia.

Mofettes - Investigation of Natural CO2 Springs - Insights and Methods applied

NASA Astrophysics Data System (ADS)

Lübben, A.; Leven, C.

2014-12-01

The quantification of carbon dioxide concentrations and fluxes leaking from the subsurface into the atmosphere is highly relevant in several research fields such as climate change, CCS, volcanic activity, or earthquake monitoring. Many of the areas with elevated carbon dioxide degassing pose the problem that under the given situation a systematic investigation of the relevant processes is only possible to a limited extent (e.g. in terms of spatial extent, accessibility, hazardous conditions). The upper Neckar valley in Southwest Germany is a region of enhanced natural subsurface CO2 concentrations and mass fluxes of Tertiary volcanic origin. At the beginning of the twentieth century several companies started industrial mining of CO2. The decreasing productivity of the CO2 springs led to the complete shutdown of the industry in 1995 and the existing boreholes were sealed. However, there are evidences that the reservoir, located in the deposits of the Lower Triassic, started to refill during the last 20 years. The CO2 springs replenished and a variety of different phenomena (e.g. mofettes and perished flora and fauna) indicate the active process of large scale CO2 exhalation. This easy-to-access site serves as a perfect example for a natural analog to a leaky CCS site, including abandoned boreholes and a suitable porous rock reservoir in the subsurface. During extensive field campaigns we applied several monitoring techniques like measurements of soil gas concentrations, mass fluxes, electrical resistivity, as well as soil and atmospheric parameters. The aim was to investigate and quantify mass fluxes and the effect of variations in e.g. temperature, soil moisture on the mass flux intensity. Furthermore, we investigated the effect of the vicinity to a mofette on soil parameters like electrical conductivity and soil CO2 concentrations. In times of a changing climate due to greenhouse gases, regions featuring natural CO2 springs demand to be intensively investigated

Evaluation of High Temperature Knitted Spring Tubes for Structural Seal Applications

NASA Technical Reports Server (NTRS)

Taylor, Shawn C.; DeMange, Jeffrey J.; Dunlap, Patrick H., Jr.; Steinetz, Bruce M.

2004-01-01

Control surface seals are crucial to current and future space vehicles, as they are used to seal the gaps surrounding body flaps, elevons, and other actuated exterior surfaces. During reentry, leakage of high temperature gases through these gaps could damage underlying lower temperature structures such as rudder drive motors and mechanical actuators, resulting in impaired vehicle control. To be effective, control surface seals must shield lower temperature structures from heat transfer by maintaining sufficient resiliency to remain in contact with opposing sealing surfaces through multiple compression cycles. The current seal exhibits significant loss of resiliency after a few compression cycles at elevated temperatures (i.e., 1900 F) and therefore would be inadequate for advanced space vehicles. This seal utilizes a knitted Inconel X-750 spring tube as its primary resilient element. As part of a larger effort to enhance seal resiliency, researchers at the NASA Glenn Research Center performed high temperature compression testing (up to 2000 F) on candidate spring tube designs employing material substitutions and modified geometries. These tests demonstrated significant improvements in spring tube resiliency (5.5x better at 1750 F) through direct substitution of heat treated Rene 41 alloy in the baseline knit design. The impact of geometry modification was minor within the range of parameters tested, however trends did suggest that moderate resiliency improvements could be obtained by optimizing the current spring tube geometry.

1. Photocopy of map (from The Virginia Springs, and the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of map (from The Virginia Springs, and the Springs of the South and West by Moorman) No date 'MAP OF ROUTES AND DISTANCES TO THE VIRGINIA SPRINGS' - White Sulphur Springs, U.S. Route 60, White Sulphur Springs, Greenbrier County, WV