Science.gov

Sample records for e26 transformation-specific ets

  1. Bombyx mori E26 transformation-specific 2 (BmEts2), an Ets family protein, represses Bombyx mori Rels (BmRels)-mediated promoter activation of antimicrobial peptide genes in the silkworm Bombyx mori.

    PubMed

    Tanaka, H; Sagisaka, A; Suzuki, N; Yamakawa, M

    2016-10-01

    E26 transformation-specific (Ets) family transcription factors are known to play roles in various biological phenomena, including immunity, in vertebrates. However, the mechanisms by which Ets proteins contribute to immunity in invertebrates remain poorly understood. In this study, we identified a cDNA encoding BmEts2, which is a putative orthologue of Drosophila Yan and human translocation-ets-leukemia/Ets-variant gene 6, from the silkworm Bombyx mori. Expression of the BmEts2 gene was significantly increased in the fat bodies of silkworm larvae in response to injection with Escherichia coli and Staphylococcus aureus. BmEts2 overexpression dramatically repressed B. mori Rels (BmRels)-mediated promoter activation of antimicrobial peptide genes in silkworm cells. Conversely, gene knockdown of BmEts2 significantly enhanced BmRels activity. In addition, two κB sites located on the 5' upstream region of cecropin B1 were found to be involved in the repression of BmRels-mediated promoter activation. Protein-competition analysis further demonstrated that BmEts2 competitively inhibited binding of BmRels to κB sites. Overall, BmEts2 acts as a repressor of BmRels-mediated transactivation of antimicrobial protein genes by inhibiting the binding of BmRels to κB sites. © 2016 The Royal Entomological Society.

  2. 12 CFR 563e.26 - Small savings association performance standards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Small savings association performance standards... COMMUNITY REINVESTMENT Standards for Assessing Performance § 563e.26 Small savings association performance standards. (a) Performance criteria—(1) Small savings associations that are not intermediate small savings...

  3. 12 CFR 563e.26 - Small savings association performance standards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Small savings association performance standards... COMMUNITY REINVESTMENT Standards for Assessing Performance § 563e.26 Small savings association performance standards. (a) Performance criteria—(1) Small savings associations that are not intermediate small savings...

  4. Mice Haploinsufficient for Ets1 and Fli1 Display Middle Ear Abnormalities and Model Aspects of Jacobsen Syndrome.

    PubMed

    Carpinelli, Marina R; Kruse, Elizabeth A; Arhatari, Benedicta D; Debrincat, Marlyse A; Ogier, Jacqueline M; Bories, Jean-Christophe; Kile, Benjamin T; Burt, Rachel A

    2015-07-01

    E26 transformation-specific 1 (ETS1) and friend leukemia integration 1 (FLI1) are members of the ETS family of transcription factors, of which there are 28 in humans. Both genes are hemizygous in Jacobsen syndrome, an 11q contiguous gene deletion disorder involving thrombocytopenia, facial dysmorphism, growth and mental retardation, malformation of the heart and other organs, and hearing impairment associated with recurrent ear infections. To determine whether any of these defects are because of hemizygosity for ETS1 and FLI1, we characterized the phenotype of mice heterozygous for mutant alleles of Ets1 and Fli1. Fli1(+/-) mice displayed mild thrombocytopenia, as did Ets1(+/-)Fli1(+/-) animals. Fli1(+/-) and Ets1(+/-)Fli1(+/-) mice also displayed craniofacial abnormalities, including a small middle ear cavity, short nasal bone, and malformed interface between the nasal bone process and cartilaginous nasal septum. They exhibited hearing impairment, otitis media, fusions of ossicles to the middle ear wall, and deformed stapes. Hearing impairment was more penetrant and stapes malformations were more severe in Ets1(+/-)Fli1(+/-) mice than in Fli1(+/-) mice, indicating partial functional redundancy of these transcription factors during auditory development. Our findings indicate that the short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 and FLI1. Copyright © 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  5. Differential requirements for the Ets transcription factor Elf-1 in the development of NKT cells and NK cells

    PubMed Central

    Choi, Hak-Jong; Geng, Yanbiao; Cho, Hoonsik; Li, Sha; Giri, Pramod Kumar; Felio, Kyrie

    2011-01-01

    E26 Transformation specific (Ets) family transcription factors control the expression of a large number of genes regulating hematopoietic cell development and function. Two such transcription factors, Ets-1 and myeloid Elf-1–like factor (MEF), have been shown to play critical roles in both natural killer (NK)– and NKT-cell development, but not in the development of conventional T cells. In this study, we address the role of E74-like factor 1 (Elf-1), another Ets family transcription factor that is closely related to MEF but divergent from Ets-1, in NK- and NKT-cell development using Elf-1–deficient (Elf-1−/−) mice. Whereas the proportion of NK cells in Elf-1−/− mice was normal, the proportion of NKT cells was significantly reduced in the thymus and periphery of Elf-1−/− mice compared with wild-type (WT) mice. Although Ets-1–deficient mice lack NKT cells altogether, Elf-1−/− mice exhibited only a partial block in NKT-cell development caused by a cell-intrinsic defect in the selection, survival, and maturation of NKT cells. In addition, residual NKT cells found in Elf-1−/− mice produced less cytokine upon antigen stimulation compared with WT NKT cells. Our data demonstrate that Elf-1 plays an important and nonredundant role in the development and function of NKT cells, but is not involved in NK-cell development. PMID:21148815

  6. Roles and regulations of the ETS transcription factor ELF4/MEF

    PubMed Central

    Suico, Mary Ann; Shuto, Tsuyoshi; Kai, Hirofumi

    2017-01-01

    Abstract Most E26 transformation-specific (ETS) transcription factors are involved in the pathogenesis and progression of cancer. This is in part due to the roles of ETS transcription factors in basic biological processes such as growth, proliferation, and differentiation, and also because of their regulatory functions that have physiological relevance in tumorigenesis, immunity, and basal cellular homoeostasis. A member of the E74-like factor (ELF) subfamily of the ETS transcription factor family—myeloid elf-1-like factor (MEF), designated as ELF4—has been shown to be critically involved in immune response and signalling, osteogenesis, adipogenesis, cancer, and stem cell quiescence. ELF4 carries out these functions as a transcriptional activator or through interactions with its partner proteins. Mutations in ELF4 cause aberrant interactions and induce downstream processes that may lead to diseased cells. Knowing how ELF4 impinges on certain cellular processes and how it is regulated in the cells can lead to a better understanding of the physiological and pathological consequences of modulated ELF4 activity. PMID:27932483

  7. Comprehensive Analysis of ETS Family Members in Melanoma by Fluorescence In Situ Hybridization Reveals Recurrent ETV1 Amplification

    PubMed Central

    Mehra, Rohit; Dhanasekaran, Saravana M; Palanisamy, Nallasivam; Vats, Pankaj; Cao, Xuhong; Kim, Jung H; Kim, David SL; Johnson, Timothy; Fullen, Douglas R; Chinnaiyan, Arul M

    2013-01-01

    E26 transformation-specific (ETS) transcription factors are known to be involved in gene aberrations in various malignancies including prostate cancer; however, their role in melanoma oncogenesis has yet to be fully explored. We have completed a comprehensive fluorescence in situ hybridization (FISH)-based screen for all 27 members of the ETS transcription factor family on two melanoma tissue microarrays, representing 223 melanomas, 10 nevi, and 5 normal skin tissues. None of the melanoma cases demonstrated ETS fusions; however, 6 of 114 (5.3%) melanomas were amplified for ETV1 using a break-apart FISH probe. For the six positive cases, locus-controlled FISH probes revealed that two of six cases were amplified for the ETV1 region, whereas four cases showed copy gains of the entire chromosome 7. The remaining 26 ETS family members showed no chromosomal aberrations by FISH. Quantitative polymerase chain reaction showed an average 3.4-fold (P value = .00218) increased expression of ETV1 in melanomas, including the FISH ETV1-amplified cases, when compared to other malignancies (prostate, breast, and bladder carcinomas). These data suggest that a subset of melanomas overexpresses ETV1 and amplification of ETV1 may be one mechanism for achieving high gene expression. PMID:23908683

  8. Reciprocal Expression of Human ETS1 and ETS2 Genes during T-Cell Activation: Regulatory Role for the Protooncogene ETS1

    DTIC Science & Technology

    1990-05-01

    viral v-ets oncogene of the E26 have studied the expression and regulation of ETS1 and ETS2 avian leukemia virus ( 1 . 2). The c-ets-i (3-5), c-ets-2...ets- 1 mRNA is detectable in different murine large granular lymphocytes, and CDll-bearing T cells. The (17-19) and human tissues (20. 21). c-ets- 1 mRNA...We have shown that: (i) the . (800 ng/ml) or a combination of PMA and ionomycin. An murine Ets-2 expression appears 1 day earlier than Ets-l optimal

  9. Gambogic acid-loaded magnetic Fe(3)O(4) nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor ETS1.

    PubMed

    Wang, Cailian; Zhang, Haijun; Chen, Yan; Shi, Fangfang; Chen, Baoan

    2012-01-01

    E26 transformation-specific sequence-1 (ETS1) transcription factor plays important roles in both carcinogenesis and the progression of a wide range of malignancies. Aberrant ETS1 expression correlates with aggressive tumor behavior and a poorer prognosis in patients with various malignancies. The aim of the current study was to evaluate the efficacy of a drug delivery system utilizing gambogic acid-loaded magnetic Fe(3)O(4) nanoparticles (GA-MNP-Fe(3)O(4)) on the suppression of ETS1-mediated cell proliferation and migration in Panc-1 pancreatic cancer cells. The effects caused by GA-MNP-Fe(3)O(4) on the proliferation of Panc-1 pancreatic cancer cells were evaluated using a MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay while inhibition of tumor cell migration was investigated in a scratch assay. The expressions of ETS1, cyclin D1, urokinase-type plasminogen activator (u-PA), and VEGF (vascular endothelial growth factor) were examined by Western blot to elucidate the possible mechanisms involved. In Panc-1 pancreatic cancer cells, we observed that application of GA-MNP-Fe(3)O(4) was able to suppress cancer cell proliferation and prevent cells from migrating effectively. After treatment, Panc-1 pancreatic cancer cells showed significantly decreased expression of ETS1, as well as its downstream target genes for cyclin D1, u-PA, and VEGF. Our novel finding reaffirmed the significance of ETS1 in the treatment of pancreatic cancer, and application of GA-MNP-Fe(3)O(4) nanoparticles targeting ETS1 should be considered as a promising contribution for better pancreatic cancer care.

  10. Ets-1 promoter-associated noncoding RNA regulates the NONO/ERG/Ets-1 axis to drive gastric cancer progression.

    PubMed

    Li, Dan; Chen, Yajun; Mei, Hong; Jiao, Wanju; Song, Huajie; Ye, Lin; Fang, Erhu; Wang, Xiaojing; Yang, Feng; Huang, Kai; Zheng, Liduan; Tong, Qiangsong

    2018-05-18

    Emerging studies have indicated the essential functions of long noncoding RNAs (lncRNAs) during cancer progression. However, whether lncRNAs contribute to the upregulation of v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets-1), an established oncogenic protein facilitating tumor invasion and metastasis, in gastric cancer remains elusive. Herein, we identified Ets-1 promoter-associated noncoding RNA (pancEts-1) as a novel lncRNA associated with the gastric cancer progression via mining of publicly available datasets and rapid amplification of cDNA ends. RNA pull-down, RNA immunoprecipitation, in vitro binding, and RNA electrophoretic mobility shift assays indicated the binding of pancEts-1 to non-POU domain containing octamer binding (NONO) protein. Mechanistically, pancEts-1 facilitated the physical interaction between NONO and Ets related gene (ERG), resulting in increased ERG transactivation and transcription of Ets-1 associated with gastric cancer progression. In addition, pancEts-1 facilitated the growth and aggressiveness of gastric cancer cells via interacting with NONO. In gastric cancer tissues, pancEts-1, NONO, and ERG were upregulated and significantly correlated with Ets-1 levels. High levels of pancEts-1, NONO, ERG, or Ets-1 were respectively associated with poor survival of gastric cancer patients, whereas simultaneous expression of all of them (HR = 3.012, P = 0.105) was not an independent prognostic factor for predicting clinical outcome. Overall, these results demonstrate that lncRNA pancEts-1 exhibits oncogenic properties that drive the progression of gastric cancer via regulating the NONO/ERG/Ets-1 axis.

  11. Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease

    SciT

    Sacchi, N.; Nalbantoglu, J.; Sergovich, F.R.

    1988-10-01

    The human ETS2 gene, a member of the ETS gene family, with sequence homology with the retroviral ets sequence of the avian erythroblastosis retrovirus E26 is located on chromosome 21. Molecular genetic analysis of Down syndrome (DS) patients with partial trisomy 21 allowed us to reinforce the supposition that ETS2 may be a gene of the minimal DS genetic region. It was originally proposed that a duplication of a portion of the DS region represents the genetic basis of Alzheimer disease, a condition associated also with DS. No evidence of either rearrangements or duplications of ETS2 could be detected inmore » DNA from fibroblasts and brain tissue of Alzheimer disease patients with either the sporadic or the familiar form of the disease. Thus, an altered ETS2 gene dosage does not seem to be a genetic cause or component of Alzheimer disease.« less

  12. Say NO to ET.

    PubMed

    Vanhoutte, P M

    2000-07-03

    The endothelial cells release both relaxing [nitric oxide (NO), endothelium-derived hyperpolarizing factor (EDHF), prostacyclin] and contracting factors [endoperoxides, thromboxane A(2), superoxide anions, endothelin-1 (ET)]. The production of ET is inhibited by NO. The latter also strongly opposes the direct effects of the former on vascular smooth muscle. With aging and vascular disease, the production of enothelial NO declines, and thus ET can be released, act and contribute to the symptoms.

  13. Photoreactivity of ETS-10.

    PubMed

    Howe, R F; Krisnandi, Y K

    2001-09-07

    Irradiation of H-ETS-10 in the presence of adsorbed methanol or ethene causes photoreduction of Ti(IV) to Ti(III); photoreduction does not occur for Na, K-ETS-10, but a photoinduced polymerization of ethene is observed.

  14. SNAP E&T

    ERIC Educational Resources Information Center

    Lower-Basch, Elizabeth

    2014-01-01

    This document provides an overview of Supplemental Nutrition Assistance Program Employment and Training (SNAP E&T). SNAP E&T is a funding source that allows states to provide employment and training and related supportive services to individuals receiving Supplemental Nutrition Assistance Program (SNAP, formerly known as food stamps)…

  15. Evapotranspiration (ET) covers.

    PubMed

    Rock, Steve; Myers, Bill; Fiedler, Linda

    2012-01-01

    Evapotranspiration (ET) cover systems are increasingly being used at municipal solid waste (MSW) landfills, hazardous waste landfills, at industrial monofills, and at mine sites. Conventional cover systems use materials with low hydraulic permeability (barrier layers) to minimize the downward migration of water from the surface to the waste (percolation), ET cover systems use water balance components to minimize percolation. These cover systems rely on soil to capture and store precipitation until it is either transpired through vegetation or evaporated from the soil surface. Compared to conventional membrane or compacted clay cover systems, ET cover systems are expected to cost less to construct. They are often aesthetic because they employ naturalized vegetation, require less maintenance once the vegetative system is established, including eliminating mowing, and may require fewer repairs than a barrier system. All cover systems should consider the goals of the cover in terms of protectiveness, including the pathways of risk from contained material, the lifecycle of the containment system. The containment system needs to be protective of direct contact of people and animals with the waste, prevent surface and groundwater water pollution, and minimize release of airborne contaminants. While most containment strategies have been based on the dry tomb strategy of keeping waste dry, there are some sites where adding or allowing moisture to help decompose organic waste is the current plan. ET covers may work well in places where complete exclusion of precipitation is not needed. The U.S. EPA Alternative Cover Assessment Program (ACAP), USDOE, the Nuclear Regulatory Commission, and others have researched ET cover design and efficacy, including the history of their use, general considerations in their design, performance, monitoring, cost, current status, limitations on their use, and project specific examples. An on-line database has been developed with information

  16. From Here to ET

    NASA Astrophysics Data System (ADS)

    Mathews, J. D.

    SETI (Search for ExtraTerrestrial Intelligence) has thus far proven negative. The assumptions that have driven these searches are reexamined to determine if a new paradigm for future searches can be identified. To this end, the apparent path of evolving human exploration of the solar system and the local galaxy is used to assess where it might lead in the relative near future while noting that we are not overtly intending to contact ET (ExtraTerrestrials). The basic premise is that human space exploration must be highly efficient, cost effective, and autonomous as placing humans beyond low Earth orbit is fraught with political, economic, and technical difficulties. With this basis, it is concluded that only by developing and deploying self-replicating robotic spacecraft--and the incumbent communication systems--can the human race efficiently explore even the asteroid belt let alone the vast reaches of the Kuiper Belt, Oort Cloud, and beyond. It is assumed that ET would have followed a similar path. The technical practicality of and our progress towards this autonomous, self-replicating exobot--Explorer roBot or EB--is further examined with the conclusion that the narrow-beam, laser-based communication network that would likely be em- ployed, would be difficult to detect from a nearby star systems thus offering an explanation of the failure of SETI to date. It is further argued, as have others, that EBs are likely a common feature of the galaxy.

  17. Implementing Embedded Training (ET): Volume 4. Identifying ET Requirements

    DTIC Science & Technology

    1988-11-01

    procedures that support the effective co::sidet·;,tion, definition, development , and integration of e::1 11cddcd trzd;Li:1r; (ET) ;~.:1p:1bilities...an effective ET compo- nent would be impossible or have undesired schedule or cost impacts. Iteration Two: Early System Development Once the new...ET. These needs can sometimes have a significant effect on the design of the prime item system. It is critical that materiel developers be made aware

  18. Rhizobium etli asparaginase II

    PubMed Central

    Huerta-Saquero, Alejandro; Evangelista-Martínez, Zahaed; Moreno-Enriquez, Angélica; Perez-Rueda, Ernesto

    2013-01-01

    Bacterial l-asparaginase has been a universal component of therapies for childhood acute lymphoblastic leukemia since the 1970s. Two principal enzymes derived from Escherichia coli and Erwinia chrysanthemi are the only options clinically approved to date. We recently reported a study of recombinant l-asparaginase (AnsA) from Rhizobium etli and described an increasing type of AnsA family members. Sequence analysis revealed four conserved motifs with notable differences with respect to the conserved regions of amino acid sequences of type I and type II l-asparaginases, particularly in comparison with therapeutic enzymes from E. coli and E. chrysanthemi. These differences suggested a distinct immunological specificity. Here, we report an in silico analysis that revealed immunogenic determinants of AnsA. Also, we used an extensive approach to compare the crystal structures of E. coli and E. chrysantemi asparaginases with a computational model of AnsA and identified immunogenic epitopes. A three-dimensional model of AsnA revealed, as expected based on sequence dissimilarities, completely different folding and different immunogenic epitopes. This approach could be very useful in transcending the problem of immunogenicity in two major ways: by chemical modifications of epitopes to reduce drug immunogenicity, and by site-directed mutagenesis of amino acid residues to diminish immunogenicity without reduction of enzymatic activity. PMID:22895060

  19. Morton et al. Reply

    NASA Technical Reports Server (NTRS)

    Morton, Douglas C.; Nagol, Jyoteshwar; Carabajal, Claudia C.; Rosette, Jacqueline; Palace, Michael; Cook, Bruce D.; Vermote, Eric F.; Harding, David J.; North, Peter R. J.

    2016-01-01

    Multiple mechanisms could lead to up-regulation of dry-season photosynthesis in Amazon forests, including canopy phenology and illumination geometry. We specifically tested two mechanisms for phenology-driven changes in Amazon forests during dry-season months, and the combined evidence from passive optical and lidar satellite data was incompatible with large net changes in canopy leaf area or leaf reflectance suggested by previous studies. We therefore hypothesized that seasonal changes in the fraction of sunlit and shaded canopies, one aspect of bidirectional reflectance effects in Moderate Resolution Imaging Spectroradiometer (MODIS) data, could alter light availability for dry-season photosynthesis and the photosynthetic capacity of Amazon forests without large net changes in canopy composition. Subsequent work supports the hypothesis that seasonal changes in illumination geometry and diffuse light regulate light saturation in Amazon forests. These studies clarify the physical mechanisms that govern light availability in Amazon forests from seasonal variability in direct and diffuse illumination. Previously, in the debate over light limitation of Amazon forest productivity, seasonal changes in the distribution of light within complex Amazon forest canopies were confounded with dry-season increases in total incoming photosynthetically active radiation. In the accompanying Comment, Saleska et al. do not fully account for this confounding effect of forest structure on photosynthetic capacity.

  20. Le cannabis et les enfants et adolescents canadiens

    PubMed Central

    Grant, Christina N; Bélanger, Richard E

    2017-01-01

    Résumé L’usage du cannabis, la drogue illicite la plus consommée dans le monde, est fréquent chez les adolescents canadiens. La consommation de cannabis à l’adolescence peut provoquer des modifications fonctionnelles et structurelles du cerveau en développement et induire une atteinte cérébrale. Dans ce groupe d’âge, la consommation de marijuana s’associe fortement à la dépendance au cannabis et à d’autres troubles de l’usage d’une substance, à l’adoption et au maintien du tabagisme, à l’augmentation des troubles de santé mentale, y compris la dépression, l’anxiété et la psychose, à une perturbation du développement neurologique et à un déclin cognitif ainsi qu’à une diminution de la performance scolaire et des réalisations au cours de la vie. Le taux de soins médicaux aigus et d’hospitalisations chez les jeunes enfants qui ont consommé involontairement du cannabis est en hausse. Compte tenu du débat en cours sur la réglementation du cannabis au Canada, l’examen attentif des preuves de ses effets sur la santé et la mise en place de mécanismes de protection deviennent des priorités absolues en santé publique.

  1. Acta Aeronautica et Astronautica Sinica,

    DTIC Science & Technology

    1983-03-04

    AD A127 840 ACTA AERONAUTICA ET ASTRONAUTICA SINICA U FOREIGN TECHNOLOGY D V WRIGHT-PATTERSON AFB OH Y ZHENG ET AL.04 MAR 83 FTD-ID(RS)T-16i05-82...UNCLASSIFIED F/G 20/4 NL IhhEllElllEEEE EohEEEEEEohhEEEI///EI/E/I// Emh /hE/ahE/hihE lllllEEllllEEEE mmhhhhhmhhmh IIII1 111 1.4 MICROCOPY RESOLUTION TEST...CHART NATIONAL BUREAU OF STANDARDS-I963-A /! FTD-ID(RS)T-1605-82 FOREIGN TECHNOLOGY DIVISION ACTA AERONAUTICA ET ASTRONAUTICA SINICA ’ MAY 1 0 983 f A

  2. Buildings operations and ETS exposure.

    PubMed Central

    Spengler, J D

    1999-01-01

    Mechanical systems are used in buildings to provide conditioned air, dissipate thermal loads, dilute contaminants, and maintain pressure differences. The characteristics of these systems and their operations h implications for the exposures of workers to environmental tobacco smoke (ETS) and for the control of these exposures. This review describes the general features of building ventilation systems and the efficacy of ventilation for controlling contaminant concentrations. Ventilation can reduce the concentration of ETS through dilution, but central heating, ventilating, and air conditioning (HVAC) can also move air throughout a building that has been contaminated by ETS. An understanding of HVAC systems is needed to develop models for exposures of workers to ETS. Images Figure 1 Figure 2 Figure 3 PMID:10375293

  3. Reply to Gopalswamy et al.

    NASA Technical Reports Server (NTRS)

    Cane, H. V.; Richardson, I. G.

    2003-01-01

    The comment of Gopalswamy et al. (thereafter GMY) relates to a letter discussing coronal mass ejections (CMEs), interplanetary ejecta and geomagnetic storms. GMY contend that Cane et al. incorrectly identified ejecta (interplanetary CMEs) and hypothesize that this is because Cane et al. fail to understand how to separate ejecta from "shock sheaths" when interpreting solar wind and energetic particle data sets. They (GMY) are wrong be cause the relevant section of the paper was concerned with the propagation time to 1 AU of any potentially geoeffective structures caused by CMEs, i.e. upstream compression regions with or without shocks, or ejecta. In other words, the travel times used by Cane et al. were purposefully and deliberately distinct from ejecta travel times (except for those slow ejecta, approx. 30% of their events, which generated no upstream features), and no error in identification was involved. The confusion of GMY stems from the description did not characterize the observations sufficiently clearly.

  4. Acta Aeronautica et Astronautica Sinica.

    DTIC Science & Technology

    1982-07-28

    AERONAUTICA ET ASTRONAUTICA SINICA - <,y English pages: 212 _r Source : Acta Aeronautica et Astronautica Sinica, Vol. 2, Nr. 4, December 1981 , . pp. 1...ADVOCATED OR IMPLIED ARE THOSE OP THE SOURCE ANDDO NOT NECESSARILY REFLECT THE POSITION TRANSLATION DIVISION OR OPINION OF THE FOREnjN TECHNOLOGY DI...axial) solution section code 2 Lower Corner Symbols i code of sectional cylindrical coordinate system j,k radial and peripheral codes of solution

  5. Diagnostic et traitement du prurit

    PubMed Central

    Nowak, Dominik; Yeung, Jensen

    2017-01-01

    Résumé Objectif Décrire une approche permettant une évaluation simplifiée et une différenciation précise des démangeaisons chez la plupart des patients dans les soins de première ligne, et offrir une mise à jour sur les traitements non pharmacologiques, topiques et systémiques à notre disposition. Sources d’information Une recherche a été effectuée dans MEDLINE (Ovid) et PubMed, à l’aide des mots-clés anglais itch ou pruritus. Pour chaque cause et chaque traitement relevé, la recherche a été affinée en ajoutant les mots-clés appropriés, et des recherches subséquentes ont été effectuées à la main dans les références des articles relevés. Message principal Il n’existe pas de bonnes données cumulées tirées d’essais de bonne qualité sur le traitement du prurit, et les traitements qui existent donnent des résultats variables. Les principales causes des démangeaisons généralisées sont la xérose et l’eczéma. Le problème se résorbe, dans la plupart des cas, à l’aide de traitements non pharmacologiques, y compris l’hydratation fréquente. En cas d’échec, des investigations plus poussées sont justifiées pour orienter le traitement subséquent à l’aide de l’une des nombreuses approches topiques et systémiques spécifiques à la cause qui sont disponibles. Conclusion Les démangeaisons chroniques peuvent être incapacitantes pour les patients. L’approche dont il est question ici permet de simplifier l’évaluation et de différencier de manière précise la plupart des démangeaisons dans les soins de première ligne. PMID:29237631

  6. Modeles de Calogero et Sutherland, fonctions speciales et symetries

    NASA Astrophysics Data System (ADS)

    Lapointe, Luc

    La thèse comporte trois volets distincts, bien que l'utilisation de méthodes algébriques soit commune aux trois parties. Le premier volet (articles 1, 2 et 3) explore la relation entre les algèbres quantiques et les q-fonctions hypergéométriques. La connexion est d'abord faite, dans ce contexte, entre une extension à deux paramètres de l'algèbre de l'oscillateur harmonique, la (p, q)- algèbre de l'oscillateur, et les fonctions hypergéométriques bibasiques. Une formule génératrice pour des déformations à deux paramètres des polynômes de Laguerre peut ainsi être obtenue. Ensuite, la connexion entre l'algèbre sl q(n + 3) et les q-fonctions de Lauricella est étudiée et, de cette façon, plusieurs identités et relations de contiguité impliquant ces fonctions sont dérivées. Ce premier volet se termine par un court article où il est montré que certaines équations de Schrödinger en deux dimensions peuvent être résolues en termes de fonctions d'Appell, le cas à deux variables des fonctions de Lauricella. Le second volet (articles 4, 5, 6, 7 et 8) porte sur le modèle de Calogero-Sutherland et les fonctions symétriques. Le modèle de Calogero- Sutherland est un modèle intégrable décrivant N particules identiques sur un cercle dont les solutions sont esssentiellement données par des fonctions symétriques à N variables, les polynômes de Jack. Une formule permettant de construire ces polynômes à l'aide d'opérateurs de création est présentée. Cette formule permet de prouver une propriété importante des polynômes de Jack. Ces opérateurs de création sont ensuite généralisés au cas des polynômes de Macdonald. Les opérateurs obtenus dans ce cas possèdent des propriétés remarquables qui permettent notamment de prouver une forme faible d'une conjecture sur les polynômes de Macdonald. Finalement, le dernier volet (articles 9, 10 et 11) traite des algèbres dynamiques et de symétrie des modèles intégrables à plusieurs

  7. ETS-5, ETS-6, and COMETS projects in Japan

    NASA Technical Reports Server (NTRS)

    Iida, Takashi; Wakana, Hiromitsu; Obara, Noriaki

    1992-01-01

    Three satellite communication projects now in progress in Japan are described. The first is a project to establish a telecommunication network for tele-education, TV conference, and tele-medicine in the Asia-Pacific region by using the Japan's Engineering Test Satellite-5 (ETS-5). The second is a project of the ETS-6 satellite, to be launched in 1993, for inter-satellite communication, mobile and fixed communication, and millimeter wave personal communication experiments. The third is a project of the Communications and Broadcasting Engineering Test Satellite (COMETS), to be launched in 1997, for advanced mobile satellite communication, inter-satellite link, and advanced broadcasting experiments at higher frequencies.

  8. ET nursing education in Australia.

    PubMed

    Thompson, J M; English, E

    1996-05-01

    Australia is comparable in size to the United States, but its population is far smaller, approximately 17 million. Australia is technologically advanced and has a high standard of health care, in which ET nursing has always been considered a specialist nursing role. Although Australia is historically linked with England, formation of closer ties with geographic neighbors, such as Southeast Asia, New Zealand, and the Pacific nations, is ongoing. This article describes some relevant aspects of the Australian context and considers the past, present, and expected future trends for ET nurse education in Australia, from the first program in 1971 to current World Council of Enterostomal Therapy-recognized programs teaching students from as far away as Japan, Israel, Singapore, Malaysia, New Zealand, China, Russia, and New Guinea. The content of the programs has progressively broadened in recognition of the expanded scope of practice, and this trend will undoubtedly continue. ET nursing should remain, however, a distinct nursing specialty practice in Australia.

  9. Insuffisance cervicale et cerclage cervical.

    PubMed

    Brown, Richard; Gagnon, Robert; Delisle, Marie-France

    2016-12-01

    La présente directive clinique a pour but de fournir un cadre de référence que les cliniciens pourront utiliser pour identifier les femmes qui sont exposées aux plus grands risques de connaître une insuffisance cervicale, ainsi que pour déterminer les circonstances en présence desquelles la mise en place d'un cerclage pourrait s'avérer souhaitable. RéSULTATS: La littérature publiée a été récupérée par l'intermédiaire de recherches menées dans PubMed ou MEDLINE, CINAHL et The Cochrane Library en 2012 au moyen d'un vocabulaire contrôlé (p. ex. « uterine cervical incompetence ») et de mots clés appropriés (p. ex. « cervical insufficiency », « cerclage », « Shirodkar », « cerclage », « MacDonald », « cerclage », « abdominal », « cervical length », « mid-trimester pregnancy loss »). Les résultats ont été restreints aux analyses systématiques, aux essais comparatifs randomisés / essais cliniques comparatifs et aux études observationnelles. Aucune restriction n'a été appliquée en matière de date ou de langue. Les recherches ont été mises à jour de façon régulière et intégrées à la directive clinique jusqu'en janvier 2011. La littérature grise (non publiée) a été identifiée par l'intermédiaire de recherches menées dans les sites Web d'organismes s'intéressant à l'évaluation des technologies dans le domaine de la santé et d'organismes connexes, dans des collections de directives cliniques, dans des registres d'essais cliniques et auprès de sociétés de spécialité médicale nationales et internationales. La qualité des résultats est évaluée au moyen des critères décrits dans le rapport du Groupe d'étude canadien sur les soins de santé préventifs (Tableau). RECOMMANDATIONS. Copyright © 2016. Published by Elsevier Inc.

  10. Response to Lefebvre et al.

    PubMed

    Takeda, K; Kou, I; Kawakami, N; Yasuhiko, Y; Ogura, Y; Imagawa, E; Miyake, N; Matsumoto, N; Sudo, H; Kotani, T; Nakamura, M; Matsumoto, M; Watanabe, K; Ikegawa, S

    2017-11-01

    Congenital scoliosis (CS) is a common vertebral malformation with incidence of up to 1 of 1000 births worldwide. Recently, TBX6 has been reported as the first disease gene for CS: about 10% of CS patients are compound heterozygotes of rare null mutations and a common haplotype composed by 3 SNPs in TBX6. Lefebvre et al in this journal reported that 2 patients with spondylocostal dysostosis (SCD), a rare skeletal dysplasia affecting spine and ribs also have TBX6 mutations: 1 carried the microdeletion and a rare missense variant, and another 2 rare missense variants. We investigated the pathogenicity of the 3 missense variants in SCD by a luciferase assay. The results were negative for the proposal of Lefebvre et al. We consider these 2 SCD patients are more probably compound heterozygotes of null mutations and a common risk haplotype just as CS patients with TBX6 mutations. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. [Behçet's disease].

    PubMed

    Wechsler, Bertrand; Du-Boutin, Lê Thi Huong; Amoura, Zahir

    2005-02-15

    Behçet's disease is a vasculitis of unknown origine. Mucocutaneous manifestations are necessary for diagnosis. Ocular and neurological involvements can lead to severe impairment. Arterial involvement may be lethal. Treatment is only symptomatic using steroids, colchicine and antiaggregant therapy. Immunosuppressive drugs are generally given for severe manifestations resistant to conventional therapy. Alpha interferon and infliximab are interesting in case of failure or relapses despite treatment. As in all chronic diseases, education and good observance are needed to improve prognosis.

  12. Erratum: Hansen et al (2014).

    PubMed

    2015-04-01

    In the article by Hansen AW, Dahl-Petersen I, Helge JW, et al, "Validation of an Internet-Based Long Version of the International Physical Activity Questionnaire in Danish Adults Using Combined Accelerometry and Heart Rate Monitoring," in J Phys Act Health, 11(3), p. 654, the DOI was listed incorrectly (10.1123/jpah.2012-0040a). This error has been fixed. The publisher apologizes for the error.

  13. Response to Lisovski et al.

    Streby, Henry M.; Kramer, Gunnar R.; Peterson, Sean M.; Lehman, Justin A.; Buehler, David A.; Andersen, David

    2018-01-01

    Lisovski et al. [1] describe the widely recognized limitations of light-level geolocator data for identifying short-distance latitudinal movements, recommend that caution be used when interpreting such data, intimated that we did not use such caution and argued that environmental shading likely explained the Golden-winged Warbler (Vermivora chrysoptera) movements described in our 2015 report [2] . Lisovski et al. [1] conclude that the bird movements we reported could not be disentangled from estimation error in stationary animals caused by environmental shading. We argue that, to the contrary, these hypotheses can easily be disentangled because the premise that environmental shading caused synchronous and parallel error among geolocators is false. With their assertion that our location estimates could be biased by >3,500 km on a day with no observable local sources of shading, Lisovski et al. [1] have taken a position of incredulity toward all geolocator-based animal movement data published to date.

  14. Behçet syndrome.

    PubMed

    Altiner, Ahmet; Mandal, Rajni

    2010-11-15

    We present a 34-year-old man with a two-year history of aphthous stomatitis, who later developed painful, erythematous nodules on his lower extremities. A pathergy test was positive, and the diagnosis of Behçet syndrome (BS) was made. It is important for the dermatologist to recognize the wide variety of cutaneous manifestations of this disorder. A pathergy test is a simple diagnostic tool that may assist in making a diagnosis. Case reports of other unusual skin manifestations in BS also are reviewed.

  15. Behçet's syndrome.

    PubMed

    Hatemi, Gulen; Yazici, Yusuf; Yazici, Hasan

    2013-05-01

    Behçet's syndrome (BS) shows a peculiar distribution, with a much higher prevalence in countries along the ancient Silk Road compared with rest of the world. BS also seems to follow a more severe course in ethnic groups with higher prevalence. Diagnosis depends on clinical findings. Criteria sets may not help in patients with less frequent types of involvement. Management strategies should be modified according to the age and sex of the patient and the organs involved. Being a serious health problem in endemic areas, BS also attracts global attention as a model to study inflammatory diseases of unknown cause. Copyright © 2013 Elsevier Inc. All rights reserved.

  16. Extragenital Lichen Sclerosus et Atrophicus

    PubMed Central

    Ganesan, Leelavathy; Parmar, Heena; Das, Jayanta Kr; Gangopadhyay, Asok

    2015-01-01

    Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory dermatosis with anogenital and extragenital presentations. Extragenital lichen sclerosus is most common on the neck, shoulders and upper trunk. Linear lesions are uncommon in LSA. We report a case of linear extragenital LSA involving forehead and scalp, along with grouped white papules of LSA in the right side of the back in a postmenopausal woman. The patient showed atypical clinical presentation of LSA in face which clinically mimicked ‘en coup de sabre’ as seen in morphea, but other clinical features suggested the diagnosis of LSA and the histopathological findings confirmed it. PMID:26288432

  17. Joint experiments using ETS-5

    NASA Astrophysics Data System (ADS)

    Nakata, Mutsumi

    1993-03-01

    An overview of the PARTNERS (Pan-Pacific Regional Telecommunications Network Research Satellite) project, which is the post-mission utilization of the ETS-5 (Engineering Test Satellite-5) is presented. The project was registered at SAFISY (Space Agency Forum for International Space Year) and includes the following experiments: (1) research on radio propagation characteristics in satellite links in Pan-Pacific region; (2) joint study on development of rural satellite network using simple mobile station; (3) experiments on telecommunication using personal computers for academic network; (4) experiments on remote education and training through satellite networks; (5) experiments on remote medicine; (6) experiments on the operation of medical information data base; (7) experiments on transmission of the earth observation data; and (8) demonstration of real time transmission of Asia-Pacific ISY (International Space Year) Conference. The experiment systems consisting of space segment (ETS-5) and simple and low cost ground system composed of 1.2 m aperture parabolic antenna, TV (Television) conference system, and terminal equipment are outlined.

  18. Consoer et al PFOS dataset

    EPA Pesticide Factsheets

    This ScienceHub entry was developed for the published paper: Consoer et al., 2016, Toxicokinetics of perfluorooctane sulfonate in rainow trout (Oncorhynchus mykiss), Environ. Toxicol. Chem. 35:717-727. Individual rainbow trout were exposed to PFOS by bolus injection (elimination studies) or by adding PFOS to incoming water (branchial uptake studies). The trout were fitted with indwelling catheters and urinary cannulae to permit periodic collection of blood and urine. Additional sampling was conducted to evaluate PFOS uptake from and elimination to respired water. Data obtained from each fish was evaluated using a clearance-volume pharmacokinetic model. Modeled kinetic parameters were then averaged to develop summary statistics which were used as a basis for interpreting modeled results and making comparisons to a previous study of rainbow trout exposed to perfluorooctanoate (PFOA; Consoer et al., 2014, Aquat. Toxicol. 156:65-73). The results of this study, combined with that of the previous PFOA study, suggest that PFOA is a substrate for renal transporters in fish while glomerular filtration alone may be sufficient to explain the observed renal elimination of PFOS. These findings demonstrate that models developed to predict the bioaccumulation of perfluoroalkyl acids by fish must account for differences in renal clearance of individual compounds.This dataset is associated with the following publication:Consoer, D., A. Hoffman , P. Fitzsimmons , P. Kosia

  19. Spectroscopic characterization of the quantum wires in titanosilicates ETS-4 and ETS-10

    NASA Astrophysics Data System (ADS)

    Yilmaz, Bilge; Warzywoda, Juliusz; Sacco, Albert, Jr.

    2006-08-01

    Titanosilicates ETS-4 and ETS-10 contain octahedrally coordinated monatomic semiconductor \\cdots \\mathrm {Ti} -O-Ti-O-\\mathrm {Ti}\\cdots (titania) chains in their frameworks. Titania chains are isolated from one another by a siliceous matrix. Thus, these chains can be regarded as one-dimensional nanostructures, i.e., 'quantum wires'. Diffuse reflectance UV-vis (DR-UV-vis) spectroscopy analysis demonstrated a significant blue-shift of the optical absorption edge (>60 nm) for both ETS-4 and ETS-10 compared to bulk titania. This blue-shift is consistent with the hypothesis that the titania chains in ETS-4 and ETS-10 are acting as quantum wires. A broad range of ETS-4 and ETS-10 samples with diverse crystallo-chemical characteristics was prepared. The DR-UV-vis and Raman spectra of various ETS-4 and ETS-10 samples exhibited different characteristics, which were hypothesized to be related to the titania chain 'quality'. Detailed investigation of the spectroscopic bands associated with the titania chains in ETS-4 was performed for the first time. The 'quality' of these titania chains/quantum wires in ETS-4 and ETS-10 was correlated with the crystal growth mechanisms of these materials. Comparison of the growth mechanisms and the spectroscopic behaviour for ETS-4 and ETS-10 suggests that the control of 'quantum wire quality' via hydrothermal synthesis is possible in ETS-4 but would be difficult in ETS-10.

  20. Behçet's disease.

    PubMed

    Saadoun, David; Wechsler, Bertrand

    2012-04-12

    DEFINITION OF THE DISEASE: Behçet disease (BD) is a chronic, relapsing, multisystemic disorder characterized by mucocutaneous, ocular, vascular and central nervous system manifestations. BD seems to cluster along the ancient Silk Road, which extends from eastern Asia to the Mediterranean basin. European cases are often described, not exclusively in the migrant population. The clinical spectrum includes oral and genital ulcerations, uveitis, vascular, neurological, articular, renal and gastrointestinal manifestations. The etiopathogenesis of the disease remains unknown, although genetic predisposition, environmental factors and immunological abnormalities have been implicated. Diagnosis is only based on clinical criteria. DIFFERRENTIAL DIAGNOSIS: It depends on the clinical presentation of BD, but sarcoidosis, multiple sclerosis, Crohn's disease, Takayasu's arteritis, polychondritis or antiphospholipid syndrome need to be considered. Treatment is symptomatic using steroids and immunomodulatory therapy. It is efficient depending on the rapidity of initiation, the compliance, and the duration of therapy. The prognosis is severe due to the ocular, neurological and arterial involvement.

  1. Functional ET(A)-ET(B) Receptor Cross-talk in Basilar Artery In Situ From ET(B) Receptor Deficient Rats.

    PubMed

    Yoon, SeongHun; Gariepy, Cheryl E; Yanagisawa, Masashi; Zuccarello, Mario; Rapoport, Robert M

    2016-03-01

    The role of endothelin (ET)(A)-ET(B) receptor cross-talk in limiting the ET(A) receptor antagonist inhibition of ET-1 constriction is revealed by the partial or complete dependency of the ET(A) receptor antagonist inhibition on functional removal of the ET(B) receptor. Although functional removal of the ET(B) receptor is generally accomplished with ET(B) receptor antagonist, a novel approach using rats containing a naturally occurring deletion mutation in the ET(B) receptor [rescued "spotting lethal" (sl) rats; ET(B)(sl/sl)] demonstrated increased ET(A) receptor antagonist inhibition of ET-1 constriction in vena cava. We investigated whether this deletion mutation was also sufficient to remove the ET(B) receptor dependency of the ET(A) receptor antagonist inhibition of ET-1 constriction in the basilar artery. Consistent with previous reports, ET-1 plasma levels were elevated in ET(B)(sl/sl) as compared with ET(B)(+/+) rats. ET(B) receptor antagonist failed to relax the ET-1 constricted basilar artery from ET(B)(+/+) and ET(B)(sl/sl) rats. Relaxation to combined ET(A) and ET(B) receptor antagonist was greater than relaxation to ET(A) receptor antagonist in the basilar artery from ET(B)(+/+) and, unexpectedly, ET(B)(sl/sl) rats. These findings confirm the presence of ET(A)-ET(B) receptor cross-talk in the basilar artery. We speculate that mutant ET(B) receptor expression produced by alternative splicing may be sufficient to allow cross-talk.

  2. Diagnostic et prise en charge du psoriasis

    PubMed Central

    Kim, Whan B.; Jerome, Dana; Yeung, Jensen

    2017-01-01

    Résumé Objectif Présenter aux cliniciens en soins primaires un aperçu pratique et à jour du diagnostic et de la prise en charge du psoriasis. Sources des données Une recension a été effectuée dans les bases de données de PubMed, MEDLINE, EMBASE et Cochrane pour trouver des méta-analyses, des études randomisées contrôlées, des revues systématiques et des études observationnelles pertinentes portant sur le diagnostic et la prise en charge du psoriasis. Message principal Le psoriasis est une maladie inflammatoire chronique et multisystémique qui affecte principalement la peau et les articulations. En plus des dimensions physiques de la maladie, le psoriasis a des répercussions émotionnelles et psychosociales considérables sur les patients, et nuit au fonctionnement social et aux relations interpersonnelles. En tant que maladie inflammatoire systémique, le psoriasis est associé à de multiples comorbidités, dont les maladies cardiovasculaires et les cancers. Le diagnostic est principalement d’ordre clinique et une biopsie de la peau est rarement nécessaire. Selon la sévérité de la maladie, un traitement approprié peut être amorcé. Pour les cas de légers à modérés, le traitement de première intention comporte des thérapies topiques, dont les corticostéroïdes, les analogues de la vitamine D3 et des produits combinés. Ces traitements topiques sont efficaces et peuvent être initiés et prescrits en toute sécurité par des médecins de soins primaires. Les patients dont les symptômes sont plus graves et réfractaires pourraient devoir être envoyés en consultation auprès d’un dermatologue pour une évaluation plus approfondie et une thérapie systémique. Conclusion De nombreux patients atteints de psoriasis consultent leur médecin de soins primaires pour une évaluation initiale et pour recevoir un traitement. La reconnaissance du psoriasis, de même que des comorbidités médicales et psychiatriques qui lui sont associ

  3. Behçet's disease

    PubMed Central

    2012-01-01

    Definition of the disease Behçet disease (BD) is a chronic, relapsing, multisystemic disorder characterized by mucocutaneous, ocular, vascular and central nervous system manifestations. Epidemiology BD seems to cluster along the ancient Silk Road, which extends from eastern Asia to the Mediterranean basin. European cases are often described, not exclusively in the migrant population. Clinical description The clinical spectrum includes oral and genital ulcerations, uveitis, vascular, neurological, articular, renal and gastrointestinal manifestations. Etiology The etiopathogenesis of the disease remains unknown, although genetic predisposition, environmental factors and immunological abnormalities have been implicated. Diagnostic methods Diagnosis is only based on clinical criteria. Differrential diagnosis It depends on the clinical presentation of BD, but sarcoidosis, multiple sclerosis, Crohn’s disease, Takayasu’s arteritis, polychondritis or antiphospholipid syndrome need to be considered. Management Treatment is symptomatic using steroids and immunomodulatory therapy. It is efficient depending on the rapidity of initiation, the compliance, and the duration of therapy. Prognosis The prognosis is severe due to the ocular, neurological and arterial involvement. PMID:22497990

  4. Seltzer_et_al_2016

    EPA Pesticide Factsheets

    This dataset supports the modeling study of Seltzer et al. (2016) published in Atmospheric Environment. In this study, techniques typically used for future air quality projections are applied to a historical 11-year period to assess the performance of the modeling system when the driving meteorological conditions are obtained using dynamical downscaling of coarse-scale fields without correcting toward higher resolution observations. The Weather Research and Forecasting model and the Community Multiscale Air Quality model are used to simulate regional climate and air quality over the contiguous United States for 2000-2010. The air quality simulations for that historical period are then compared to observations from four national networks. Comparisons are drawn between defined performance metrics and other published modeling results for predicted ozone, fine particulate matter, and speciated fine particulate matter. The results indicate that the historical air quality simulations driven by dynamically downscaled meteorology are typically within defined modeling performance benchmarks and are consistent with results from other published modeling studies using finer-resolution meteorology. This indicates that the regional climate and air quality modeling framework utilized here does not introduce substantial bias, which provides confidence in the method??s use for future air quality projections.This dataset is associated with the following publication:Seltzer, K., C

  5. Algorithmes de couplage RANS et ecoulement potentiel

    NASA Astrophysics Data System (ADS)

    Gallay, Sylvain

    Dans le processus de developpement d'avion, la solution retenue doit satisfaire de nombreux criteres dans de nombreux domaines, comme par exemple le domaine de la structure, de l'aerodynamique, de la stabilite et controle, de la performance ou encore de la securite, tout en respectant des echeanciers precis et minimisant les couts. Les geometries candidates sont nombreuses dans les premieres etapes de definition du produit et de design preliminaire, et des environnements d'optimisations multidisciplinaires sont developpes par les differentes industries aeronautiques. Differentes methodes impliquant differents niveaux de modelisations sont necessaires pour les differentes phases de developpement du projet. Lors des phases de definition et de design preliminaires, des methodes rapides sont necessaires afin d'etudier les candidats efficacement. Le developpement de methodes ameliorant la precision des methodes existantes tout en gardant un cout de calcul faible permet d'obtenir un niveau de fidelite plus eleve dans les premieres phases de developpement du projet et ainsi grandement diminuer les risques associes. Dans le domaine de l'aerodynamisme, les developpements des algorithmes de couplage visqueux/non visqueux permettent d'ameliorer les methodes de calcul lineaires non visqueuses en methodes non lineaires prenant en compte les effets visqueux. Ces methodes permettent ainsi de caracteriser l'ecoulement visqueux sur les configurations et predire entre autre les mecanismes de decrochage ou encore la position des ondes de chocs sur les surfaces portantes. Cette these se focalise sur le couplage entre une methode d'ecoulement potentiel tridimensionnelle et des donnees de section bidimensionnelles visqueuses. Les methodes existantes sont implementees et leurs limites identifiees. Une methode originale est ensuite developpee et validee. Les resultats sur une aile elliptique demontrent la capacite de l'algorithme a de grands angles d'attaques et dans la region post

  6. Japanese propagation experiments with ETS-5

    NASA Technical Reports Server (NTRS)

    Ikegami, Tetsushi

    1989-01-01

    Propagation experiments for maritime, aeronautical, and land mobile satellite communications were performed using Engineering Test Satellite-Five (ETS-5). The propagation experiments are one of major mission of Experimental Mobile Satellite System (EMSS) which is aimed for establishing basic technology for future general mobile satellite communication systems. A brief introduction is presented for the experimental results on propagation problems of ETS-5/EMSS.

  7. Pike International, LLC et al. Information Sheet

    EPA Pesticide Factsheets

    Pike International LLC, et al. (the Company) is located in New Haven, Connecticut. The Complaint involves the lease of, and renovation activities conducted at, property constructed prior to 1978, located in New Haven, Connecticut.

  8. Protective Role of Ets1 in SLE

    DTIC Science & Technology

    2014-07-01

    reminiscent of those of T cells of lupus patients. Ets1 directly binds to the il10 gene and recruited histone deacetylase, thereby suppressing the...15. SUBJECT TERMS Ets1, IL-10, IL-2, Fcgr2b, lupus 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES... lupus , there is still no effective treatment or cure for this life-threatening disease. The lack of progress in developing new treatments for lupus

  9. ETS-Associated Genomic Alterations including ETS2 Loss Markedly Affect Prostate Cancer Progression

    DTIC Science & Technology

    2015-10-01

    upregulation of ERG, a transcription factor with oncogenic roles in other cancers such as leukemias and sarcomas (Tomlins, Rhodes et al. 2005; Turner ...represses Apc(Min)-mediated tumours in mouse models of Down’s syndrome ." Nature 451(7174): 73-75. Taylor, B. S., N. Schultz, et al. (2010...generation antiandrogen for treatment of advanced prostate cancer." Science 324(5928): 787-790. Turner , D. P. and D. K. Watson (2008). "ETS transcription

  10. ETS-VI multibeam satellite communications systems

    NASA Astrophysics Data System (ADS)

    Kawai, Makoto; Tanaka, Masayoshi; Ohtomo, Isao

    1989-10-01

    The fixed and mobile satellite communications systems of the Japanese Engineering Test Satellite-VI (ETS-VI) are described. The system requirements are outlined along with the system configuration. The ETS-VI multibeam system employs three frequency bands. When used for Ka-band fixed communications, it covers the Japanese main islands with thirteen 0.3-degree-wide spot beam. Four of the beams are active for ETS-VI. When used for S-band mobile communications, five beams cover the area within 200 nautical miles from the Japanese coast. The C-band beam for fixed communications covers the central area of the Japanese main islands with a single beam. The onboard antenna system is described along with the transponders and their associated onboard systems. A discussion of the system technology follows, covering the TDMA transmisssion system, the relay function, rainfall compensation, and the antenna and propagation performance.

  11. J. Picard et les satellites de Saturne.

    NASA Astrophysics Data System (ADS)

    Toulmonde, M.

    Jean Picard (1620 - 1682) a observé à Paris les trois premiers satellites de Saturne récemment découverts et en a dessiné les configurations. Par la comparaison avec les théories les plus récentes des mouvements des satellites de Saturne, l'étude de ces observations et des croquis réalisés par Picard montre les très grandes qualités des satellites de Saturne, l'étude de ces observations et des croquis réalisés par Picard montre les très grande qualités d'observateur de cet astronome, créateur de l'astronométrie de précision dès 1666.

  12. Ewing sarcoma: a chronicle of molecular pathogenesis.

    PubMed

    Kim, Sang Kyum; Park, Yong-Koo

    2016-09-01

    Sarcomas have traditionally been classified according to their chromosomal alterations regardless of whether they accompany simple or complex genetic changes. Ewing sarcoma, a classic small round cell bone tumor, is a well-known mesenchymal malignancy that results from simple sarcoma-specific genetic alterations. The genetic alterations are translocations between genes of the TET/FET family (TLS/FUS, EWSR1, and TAF15) and genes of the E26 transformation-specific (ETS) family. In this review, we intend to summarize a chronicle of molecular findings of Ewing sarcoma including recent advances and explain resultant molecular pathogenesis. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. MicroRNA221-3p modulates Ets-1 expression in synovial fibroblasts from patients with osteoarthritis of temporomandibular joint.

    PubMed

    Xu, J; Liu, Y; Deng, M; Li, J; Cai, H; Meng, Q; Fang, W; Long, X; Ke, J

    2016-11-01

    This study aimed to screen differential expression of microRNAs (miRNAs), and investigate function of the specifically selected miRNA in synovial fibroblasts from patients suffering osteoarthritis of temporomandibular joint (TMJOA). MiRNA microarray was used to select differentially expressed miRNAs between TMJOA and normal synovial fibroblasts. The expression of screened miRNA221-3p was quantified using real-time PCR, and its specific target gene was predicted by bioinformatics. After transfection of miRNA221-3p mimics or inhibitor into synovial fibroblasts, the expression of v-Ets avian erythroblastosis virus E26 oncogene homolog 1 (Ets-1) was detected by immunohistochemistry, real-time PCR and Western blot, respectively. Dual luciferase activity was performed to identify the direct regulation of miRNA221-3p on Ets-1. Interlukin-1β (IL-1β) mimics an inflammatory situation. In TMJOA synovial fibroblasts, eight miRNAs were up-regulated and six miRNAs were down-regulated. MiRNA221-3p was the most down-expressed. A sequence in the 3'-untranslated (3'-UTR) of Ets-1 complementary to the seed sequence of miRNA221-3p. Elevated expression of Ets-1 associated with attenuation of miRNA221-3p. Over-expression of miRNA221-3p suppressed the activity of a reporter construct containing the 3'-UTR of Ets-1 transcript and inhibited the expression of Ets-1 as well as its downstream molecules, matrix metalloproteinase 1 (MMP1) and MMP9 in TMJOA synovial fibroblasts. IL-1β suppressed the expression of miRNA221-3p in both a dose-dependent and time-dependent manner. The reduction of miRNA221-3p in synovial fibroblasts, attributed from abundance of IL-1β in inflamed circumstance, induces Ets-1 up-regulation and then, initiates MMP1 and MMP9 secretion, thereby leading to continuously pathological development in TMJOA. Copyright © 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  14. Abundant spontaneous VLFE activities in Cascadia during ETS and inter-ETS time periods

    NASA Astrophysics Data System (ADS)

    Ghosh, A.; Hutchison, A. A.; Hawthorne, J.

    2017-12-01

    Very low frequency earthquakes (VLFEs) are discrete seismic events associated with episodic tremor and slip (ETS) events. They are rich in 20-50s energy and depleted in higher frequencies compared to regular local earthquakes of similar magnitudes. VLFEs can be as large as Mw 4.0, and potentially release much more seismic moment than the tremor/LFE activities, making them a critical event determining stress evolution during slow earthquakes [Ghosh et al., 2015]. Their underlying physics and relationship with tremor/LFE, however, are still unclear. In Cascadia, the majority of the VLFEs found so far are clustered near the areas of high geodetic slip during ETS events [Ghosh et al., 2015; Hutchison and Ghosh, 2016]. Interestingly, we found VLFE activity has its own dynamics and can occur independent of tremor/LFE activity. For example, during the 2014 ETS event in northern Cascadia, VLFEs are found to be asynchronous with tremor activity, both in space and time [Hutchison and Ghosh, 2016]. We use a matched filter technique to detect thousands of VLFEs over an ETS-cycle, and perhaps more interestingly, even between ETS events. VLFE activities peak during ETS events, but significant VLFE activity is detected during the inter-ETS time period. Analyses of strainmeter data near the VLFE locations suggest statistically significant strain rate increases during VLFE time periods compared to the background. We suggest that VLFE is a distinct type of seismic radiation different from tremor/LFE, and can operate independently from tremor activities. This is in contrast to a model suggesting that VLFE signals may be a result of many LFE signals arriving at seismic stations in a short time period [Gomberg et al., 2016]. We are making a consistent catalog of VLFE in Cascadia for longer time period. Systematic study of VLFEs is going to provide new insights into the mechanism of slow earthquakes and its relationship with tremor/LFE and slow slip.

  15. Management of Behçet's syndrome.

    PubMed

    Ozguler, Yesim; Hatemi, Gulen

    2016-01-01

    Current trends in the management of Behçet's syndrome will be reviewed in this article. Biologic agents have gained increasing importance over the years in the management of Behçet's syndrome. Long-term results of observational studies have shown that anti-tumor necrosis factor agents may be effective in Behçet's syndrome patients with refractory eye involvement. Case series reporting about use of anti-tumor necrosis factor agents in vascular and gastrointestinal involvement have also shown good results. Caution is required for infectious complications with these agents. Apremilast is an immunomodulatory agent that works through phosphodiesterase 4 inhibition. A randomized controlled trial has shown that it is effective for the management of oral and genital ulcers and is generally well tolerated. The outcome of Behçet's syndrome with major organ involvement has improved with more effective management strategies, especially with the use of biologic agents in severe cases. Controlled trials are needed to guide physicians in making treatment decisions.

  16. Goldstone Radar Images of Asteroid 2013 ET

    2013-03-18

    This sequence of radar images of asteroid 2013 ET was obtained on Mar. 10, 2013, by NASA scientists using the 230-foot 70-meter DSN antenna at Goldstone, CA, when the asteroid was about 693,000 mi 1.1 million km from Earth.

  17. Teaching Physics Using PhET Simulations

    ERIC Educational Resources Information Center

    Wieman, C. E.; Adams, W. K.; Loeblein, P.; Perkins, K. K.

    2010-01-01

    PhET Interactive Simulations (sims) are now being widely used in teaching physics and chemistry. Sims can be used in many different educational settings, including lecture, individual or small group inquiry activities, homework, and lab. Here we will highlight a few ways to use them in teaching, based on our research and experiences using them in…

  18. Autisme et douleur – analyse bibliographique

    PubMed Central

    Dubois, Amandine; Rattaz, Cécile; Pry, René; Baghdadli, Amaria

    2010-01-01

    La présente analyse bibliographique a pour objectif de réaliser un bilan des travaux publiés dans le champ de la douleur et de l’autisme. L’article aborde, dans un premier temps, les études publiées concernant les modes d’expression de la douleur observés dans cette population. Différentes hypothèses permettant d’expliquer les particularités expressives des personnes avec autisme sont ensuite passées en revue : excès d’endorphines, particularités dans le traitement sensoriel, déficit sociocommunicatif. Cette analyse bibliographique aborde, pour terminer, la question de l’évaluation et de la prise en compte de la douleur chez les personnes avec autisme. Les auteurs concluent à l’absence d’homogénéité des résultats des études publiées et au besoin de poursuivre les recherches afin de parvenir à des données consensuelles sur un domaine d’étude encore peu exploité au plan scientifique. Sur un plan clinique, l’approfondissement des connaissances dans ce domaine devrait permettre de mettre au point des outils d’évaluation de la douleur et d’ainsi en assurer une meilleure prise en charge au quotidien. PMID:20808970

  19. ETS Psychometric Contributions: Focus on Test Scores. Research Report. ETS RR-13-15. ETS R&D Scientific and Policy Contributions Series. ETS SPC-13-03

    ERIC Educational Resources Information Center

    Moses, Tim

    2013-01-01

    The purpose of this report is to review ETS psychometric contributions that focus on test scores. Two major sections review contributions based on assessing test scores' measurement characteristics and other contributions about using test scores as predictors in correlational and regression relationships. An additional section reviews additional…

  20. Data used in Xu et al., 2016

    EPA Pesticide Factsheets

    Mercury emissions data from anthropogenic sources as described in Xu et al., 2016.This dataset is associated with the following publication:Xu, X., N. Liu, M. Landis, X. Feng, and G. Qiu. Characteristics and distributions of atmospheric mercury emitted from anthropogenic sources in Guiyang, southwestern China. Acta Geochimica. Springer, Heidelburg, GERMANY, 1-11, (2016).

  1. The "Conservatoire National des Arts et Metiers"

    ERIC Educational Resources Information Center

    Kuhn, Gerard

    2004-01-01

    The overall mission of the Conservatoire national des arts et metiers--(CNAM) [National Conservatory of Industrial Arts and Trades] is outlined. One of its centers, the "Centre national de l'entrepreneuriat"--(CNE) [National Center for Entrepreneurship] is described in greater detail. In particular, this center offers various services, notably…

  2. Hughes et al.: Science or Promotion?

    ERIC Educational Resources Information Center

    Loman, L. Anthony; Siegel, Gary L.

    2013-01-01

    The Hughes et al. paper is critiqued generally and in specific areas. The weak nature of the authors' empirical work is discussed along with their enigmatic writing and vague and incorrect use of references, and their simultaneous use of sweeping statements of opinion and narrow analytical focus. This review examines the authors' errors…

  3. A reply to King et al

    Mark E. Swanson; Jerry F. Franklin; Robert L. Beschta; Charles M. Crisafulli; Dominick A. DellaSala; Richard Hutto; David Lindenmayer; Frederick J. Swanson

    2011-01-01

    King et al are correct in their assessment of an increase in research and management interest in early successional stages after disturbance. But their claim that “... the conservation status of species that depend on early successional forest is now widely appreciated by natural resource management agencies” merits further reflection. Etc.

  4. Bierman {ital et al.}Reply:

    SciT

    Bierman, J.D.; Chan, P.; Liang, J.F.

    1997-05-01

    reply to the Comment by C.H.Dasso et al., Phys. Rev. Lett. 78,XXX(1997). A Reply to the Comment by C.H. Dasso and J. Fern{acute a}ndez-Niello. {copyright} {ital 1997} {ital The American Physical Society}

  5. E.T.: Preschool Children's Perceptions.

    ERIC Educational Resources Information Center

    Roscoe, Bruce; Peterson, Karen L.

    An exploratory study investigated preoperational children's understanding of the fictional movie character E.T. (The Extra-Terrestrial). Of 40 participating children (ages 40 to 66 months), 85 percent indicated they had seen the movie. Data were collected according to an interview method, and responses were recorded on audiotape, transcribed, and…

  6. Synthesis and adsorption properties of titanosilicates ETS-4 and ETS-10 from fly ash.

    PubMed

    Liu, Liying; Singh, Ranjeet; Li, Gang; Xiao, Penny; Webley, Paul; Zhai, Yuchun

    2011-11-15

    ETS-4 and ETS-10 titanosilicates were prepared from fly ash and anatase, as silica and titanium sources respectively, via a hydrothermal procedure for the first time. The fusion of fly ash by alkali was carried out at a relatively low temperature and the use potassium fluoride salt was avoided in the synthesis of ETS. The by-product of this process is mainly NaCl, which is a useful source material for industry. The energy efficiency and yield of the synthesis process was improved by directly recycling the final filtrate after recovering the product viz ETS-4. All the ETS materials were characterized in terms of structural morphology, thermal stability and surface/pore properties. The properties of ETS-4 prepared from fly ash by the filtrate recycling method were comparable to that from commercial sources. The results show that ETS type materials can be prepared from cheaper resources, with good purity, comparable physico-chemical properties as well as excellent adsorption properties with lower environmental impact. Copyright © 2011 Elsevier B.V. All rights reserved.

  7. Cooling Effect of Evapotranspiration (ET) and ET Measurement by Thermal Remote Sensing in Urban

    NASA Astrophysics Data System (ADS)

    Qiu, G. Y.; Yang, B.; Li, X.; Guo, Q.; Tan, S.

    2015-12-01

    Affected by global warming and rapid urbanization, urban thermal environment and livability are getting worse over the world. Global terrestrial evapotranspiration (ET) can annually consume 1.483 × 1023 joules of solar energy, which is about 300 times of the annual human energy use on the earth (4.935×1020 joules). This huge amount of energy use by ET indicates that there is great potential to cool the urban by regulating ET. However, accurately measurement of urban ET is quiet difficult because of the great spatial heterogeneity in urban. This study focuses on to quantify the cooling effects ET by mobile traverse method and improve a methodology to measure the urban ET by thermal remote sensing. The verifying experiment was carried out in Shenzhen, a sub-tropical mega city in China. Results showed that ET of vegetation could obviously reduce the urban temperature in hot season. Daily transpiration rate of a small-sized Ficus tree (Ficus microcarpa, 5 m in height and 20 cm of trunk diameter, measured by sap-flow method) was 36-55 kg and its cooling effect was equivalent to a 1.6-2.4 kWh air conditioner working for 24 hours. A 10% increase in the vegetated area could decrease urban temperature by 0.60°C at hot night. Moreover, it was found that a region with a vegetated area ratio over 55% had obvious effect on temperature decreasing. In addition, a methodology by using "thermal remote sensing + three-temperature model" was improved to measure the urban ET. Results showed that the urban ET could be reasonably measured by the proposed method. The daily ET of an urban lawn was 0.01-2.86 mm and monthly ET was 21-60 mm. This result agreed well with the verification study (Bowen ratio method, r=0.953). These results are very useful for urban planning, urban lower impact development, and improving of urban thermal environment.

  8. DOE DISS/ET pilot system

    SciT

    Strait, R.S.; Wagner, E.E.

    1994-07-01

    The US Department of Energy (DOE) Office of Safeguards and Security initiated the DOE Integrated Security System / Electronic Transfer (DISS/ET) for the purpose of reducing the time required to process security clearance requests. DISS/ET will be an integrated system using electronic commerce technologies for the collection and processing of personnel security clearance data, and its transfer between DOE local security clearance offices, DOE Operations Offices, and the Office of Personnel Management. The system will use electronic forms to collect clearance applicant data. The forms data will be combined with electronic fingerprint images and packaged in a secure encrypted electronicmore » mail envelope for transmission across the Internet. Information provided by the applicant will be authenticated using digital signatures. All processing will be done electronically.« less

  9. Fibrillation auriculaire et activité physique

    PubMed Central

    Bosomworth, N. John

    2015-01-01

    Résumé Objectif Examiner les données probantes portant sur les effets de divers niveaux d’activité physique sur l’incidence de fibrillation auriculaire (FA) dans la population générale et chez les athlètes d’endurance. Sources des données Une recherche a initialement été menée sur PubMed à l’aide des titres MeSH ou des mots-de-texte anglais (avec descripteur de zone de recherche TIAB [title and abstract]) atrial fibrillation et exercise ou physical activity ou athlet* ou sport*, sans filtre additionnel. Le système GRADE (grading of recommendations, assessment, development, and evaluation) a été utilisé pour tirer les conclusions au sujet de la qualité et du niveau de preuve. Sélection des études Aucune étude d’intervention n’est ressortie de la recherche. Les études d’observation ont alors été jugées acceptables et, bien que des études prospectives de cohortes à long terme de plus grande envergure auraient été préférables, des essais cas-témoins ou transversaux ont aussi été inclus dans cette révision. Synthèse Les données disponibles laissent croire à un lien proportionnel à la dose entre l’exercice plus intense et l’incidence réduite de FA chez les femmes. Il en va de même pour les hommes dont le niveau d’activité physique est de faible à modéré. Chez les hommes seulement, l’activité intense est associée à un risque accru de FA et ce, dans la plupart des études, mais pas la totalité d’entre elles. Ce risque est modéré, le rapport de risque instantané étant de 1,29 dans l’une des études de meilleure qualité. Le risque de FA chez la plupart des personnes régulièrement actives est plus faible que le risque observé dans la population sédentaire appariée. Conclusion La fibrillation auriculaire est probablement moins fréquente à mesure que le niveau d’activité physique augmente, la relation dose-réponse étant démontrable. À toutes les intensités, l’exercice doit être

  10. Risk Management in ETS-8 Project

    NASA Astrophysics Data System (ADS)

    Homma, M.

    2002-01-01

    Engineering Test Satellite - 8 (ETS-8) is the Japanese largest geo-synchronous satellite of 3 tons in mass, of which mission is mobile communications and navigation experiment. It is now in the flight model manufacturing phase. This paper introduces the risk management taken in this project as a reference. The mission success criteria of ETS-8 are described at first. All the risk management activities are planned taking these criteria into consideration. ETS-8 consists of many new technologies such as the large deployable antenna (19m x 17m), 64-bit MPU, 100 V solar paddle and so on. We have to pay attention to control these risk through each phase of development. In system design of ETS - 8, almost components have redundancy and there is some back-up function to avoid fatal failure. What kind of back-up function should be taken is one of the hot issues in this project. The consideration process is described as an actual case. In addition to conventional risk management procedure, FMEA and identification of the critical items so on, we conducted the validation experiment in space by use of a scale model that was launched on Ariane 5. The decision to conduct this kind of experiment is taken after evaluation between risk and cost, because it takes a lot of resources of project. The effect of this experiment is also presented. Failure detection, isolation and reconfiguration in the flight software are more important as the satellite system becomes large and complicated. We did the independent verification and validation to the software. Some remarks are noted with respect to its effectiveness.

  11. PoET: Polarimeters for Energetic Transients

    NASA Technical Reports Server (NTRS)

    McConnell, Mark; Barthelmy, Scott; Hill, Joanne

    2008-01-01

    This presentation focuses on PoET (Polarimeters for Energetic Transients): a Small Explorer mission concept proposed to NASA in January 2008. The principal scientific goal of POET is to measure GRB polarization between 2 and 500 keV. The payload consists of two wide FoV instruments: a Low Energy Polarimeter (LEP) capable of polarization measurements in the energy range from 2-15 keV and a high energy polarimeter (Gamma-Ray Polarimeter Experiment - GRAPE) that will measure polarization in the 60-500 keV energy range. Spectra will be measured from 2 keV up to 1 MeV. The PoET spacecraft provides a zenith-pointed platform for maximizing the exposure to deep space. Spacecraft rotation will provide a means of effectively dealing with systematics in the polarization response. PoET will provide sufficient sensitivity and sky coverage to measure statistically significant polarization for up to 100 GRBs in a two-year mission. Polarization data will also be obtained for solar flares, pulsars and other sources of astronomical interest.

  12. Reply to Comment by Nishimura Et Al.

    NASA Astrophysics Data System (ADS)

    Mozer, F. S.; Hull, A.; Lejosne, S.; Vasko, I. Y.

    2018-03-01

    Nishimura et al. (2010, https://doi.org/10.1126/science.1193186, 2011, https://doi.org/10.1029/2011JA016876, 2013, https://doi.org/10.1029/2012JA018242, and in their comment, hereafter called N18) have suggested that chorus waves interact with equatorial electrons to produce pulsating auroras. We agree that chorus can scatter electrons >10 keV, as do Time Domain Structures (TDSs). Lower-energy electrons occurring in pulsating auroras cannot be produced by chorus, but such electrons are scattered and accelerated by TDS. TDSs often occur with chorus and have power in their spectra at chorus frequencies. Thus, the absence of power at low frequencies is not evidence that TDSs are absent, as an example shows. Through examination of equatorial electric field waveforms and electron pitch angle distributions measured on the Time History of Events and Macroscale Interactions during Substorms satellites (in place of examining field and particle spectra, as done by Nishimura et al.), we show that chorus cannot produce the field-aligned electrons associated with pulsating auroras in the Nishimura et al. (2010, https://doi.org/10.1126/science.1193186) events, but TDSs can. Equatorial field-aligned electron distributions associated with pulsating auroras and created by TDS in the absence of chorus or any other wave at the equator are also shown.

  13. Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors

    PubMed Central

    Wenner, Megan M.; Taylor, Hugh S.

    2013-01-01

    Hyperandrogenism and vascular dysfunction often coexist in women with polycystic ovary syndrome (PCOS). We hypothesized that testosterone compromises cutaneous microvascular dilation in women with PCOS via the endothelin-1 ET-B subtype receptor. To control and isolate testosterone's effects on microvascular dilation, we administered a gonadotropin-releasing hormone antagonist (GnRHant) for 11 days in obese, otherwise healthy women [controls, 22.0 (4) yr, 36.0 (3.2) kg/m2] or women with PCOS [23 (4) yr, 35.4 (1.3) kg/m2], adding testosterone (T; 2.5 mg/day) on days 8–11. Using laser Doppler flowmetry and cutaneous microdialysis, we measured changes in skin microcirculatory responsiveness (ΔCVC) to local heating while perfusing ET-A (BQ-123) and ET-B (BQ-788) receptor antagonists under three experimental conditions: baseline (BL; prehormone intervention), GnRHant (day 4 of administration), and T administration. At BL, ET-A receptor inhibition enhanced heat-induced vasodilation in both groups [ΔCVC control 2.03 (0.65), PCOS 2.10 (0.25), AU/mmHg, P < 0.05]; ET-B receptor inhibition reduced vasodilation in controls only [ΔCVC 0.98 (0.39), 1.41 (0.45) AU/mmHg for controls, PCOS] compared with saline [ΔCVC controls 1.27 (0.48), PCOS 1.31 (0.13) AU/mmHg]. GnRHant enhanced vasodilation in PCOS [saline ΔCVC 1.69 (0.23) AU/mmHg vs. BL, P < 0.05] and abolished the ET-A effect in both groups, a response reasserted with T in controls. ET-B receptor inhibition reduced heat-induced vasodilation in both groups during GnRHant and T [ΔCVC, controls: 0.95 (0.21) vs. 0.51 (13); PCOS: 1.27 (0.23) vs. 0.84 (0.27); for GnRHant vs. T, P < 0.05]. These data demonstrate that androgen suppression improves microvascular dilation in PCOS via ET-A and ET-B receptors. PMID:23921139

  14. Nouveautes Dans la Reconstruction Cutanee: Cultures de Cellules et Substituts Dermiques et Revue de la Litterature

    PubMed Central

    Koch, N.; Erba, P.; Benathan, M.; Raffoul, W.

    2010-01-01

    Summary La prise en charge de patients souffrant de brûlures profondes et étendues reste un défi important pour les chirurgiens reconstructeurs. Ceci est d'autant plus vrai que les grands progrès réalisés dans la réanimation assurent actuellement la survie de patients brûlés sur plus de 90% de leur surface corporelle. De ce fait la reconstruction moderne a dû innover et est devenue une chirurgie complexe nécessitant un plan stratégique impliquant des matériaux et des méthodes chirurgicales multiples adaptées à chaque situation clinique. Ce type de prise en charge nécessite aussi la collaboration étroite et coordonnée de plusieurs équipes hautement spécialisées. Le taux de survie ainsi que de la qualité de vie de ces patients sont alors nettement améliorés. De même nous observons clairement que le nombre de complications secondaires telles que les rétractions et les instabilités cicatricielles ont également diminué de façon significative. Mots-clés: brûlure, greffe, culture, substitut dermique, reconstruction PMID:21991212

  15. Erratum: Lakes et al (2017).

    PubMed

    2018-05-01

    In the article by Lakes KD, Abdullah MM, Youssef J, et al. Assessing parent perceptions of physical activity in families of toddlers with neurodevelopmental disorders: The Parent Perceptions of Physical Activity Scale (PPPAS), Pediatr Exerc Sci. 2017; 29: 396-407, https://doi.org/10.1123/pes.2016-0213 , an author's name was incorrectly listed. Shlomit Aizik should have been listed as Shlomit Radom-Aizik. The online version of this article has been corrected. We apologize for this error.

  16. Conduite automobile et démence

    PubMed Central

    Lee, Linda; Molnar, Frank

    2017-01-01

    Résumé Objectif Fournir aux médecins de première ligne une approche relative aux préoccupations de sécurité au volant lorsque les personnes âgées présentent des troubles de mémoire. Sources d’information L’approche est fondée sur un programme de formation agréé des cliniques de la mémoire, élaboré par la clinique de la mémoire du Centre for Family Medicine. Message principal L’un des aspects les plus difficiles des soins aux personnes atteintes de démence est l’évaluation de la sécurité au volant. Les conducteurs atteints de démence présentent un risque plus élevé de collisions, quoique de nombreux conducteurs dont l’atteinte est légère soient aptes à conduire pendant encore plusieurs années. Puisque l’aptitude à conduire dépend de multiples compétences cognitives et fonctionnelles, de nombreux facteurs entrent en jeu lorsque les cliniciens déterminent si les sujets de préoccupation en matière de cognition se répercutent sur l’aptitude à conduire. Les observations spécifiques tirées de l’anamnèse corroborée et des tests cognitifs effectués en cabinet pourraient aider le médecin à décider s’il doit recommander le patient à un examen pratique complet et aviser les autorités provinciales du transport, conformément aux exigences en matière de déclarations. La communication doit être axée sur le patient et menée avec tact. Conclusion Les médecins de première ligne doivent tenir compte de plusieurs facteurs lorsqu’ils déterminent si les sujets de leurs préoccupations en matière de cognition pourraient se répercuter sur l’aptitude des conducteurs âgés à prendre le volant. PMID:28115452

  17. [CARDIOVASCULAR INVOLVEMENTS IN BEHÇET'S DISEASE: "ANGIO-BEHÇET"].

    PubMed

    Tridetti, J; Benoit, A; Borgoens, P; Hoffer, E

    2016-01-01

    Behçet's disease is a relapsing, immune-mediated systemic vasculitis that may affect blood vessels of all types and sizes. Nowadays, the etiology remains unclear. In the absence of a biological marker or pathognomonic radiology, the diagnosis is mainly based on clinical manifestations. The cardiovascular involvement, known as "angio-Behçet", is relatively common and affects up to 40% of patients. It typi- cally occurs in a young male, usually during the onset of the disease. In general, immunosuppressive and anticoagulant therapies initiated early are likely to induce a remarkable cli- nical improvement. Nevertheless, prompt recognition of the polymorphous cardiovascular manifestations of the disease is challenging and may be responsible for some considerable delay prior to initiation of adequate therapy. The aim of this article is to describe the spectrum of cardiovascular involve- ments of Behçet's disease in order to optimize detection and therapeutic management.

  18. 77 FR 67689 - Fidelity Aberdeen Street Trust, et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ...] Fidelity Aberdeen Street Trust, et al.; Notice of Application November 6, 2012. AGENCY: Securities and... arrangements (``Prior Order'').\\1\\ \\1\\ Colchester Street Trust, et al., Investment Company Act Release Nos... Trust, et al., Investment Company Act Release Nos. 23787 (Apr. 15, 1999) (notice) and 23831 (May 11...

  19. Monoethanolamine Impregnation of Titanosilicate Zeolite ETS-10.

    PubMed

    Tanchuk, Brenden; Sawada, James A; Kuznicki, Steven M

    2015-03-01

    ETS-10, a mixed octahedral/tetrahedral titanosilicate molecular sieve, has a unique architecture where its 0.8 nm pores are lined exclusively with silicon which imparts a high degree of chemical stability, yet the anionic framework can be modified by cation exchange. In this work, the hydrogen-exchanged form of ETS-10 was impregnated with monoethanolamine and the thermal stability and CO2 adsorption characteristics were analyzed. The surface area of the material was characterized by N2 physisorption, the thermal stability of the material assessed through TG-MS experiments, the CO2 capacity was measured via static volumetric adsorption experiments, and the influence of moisture as a carbamate promoter was investigated through a series of gravimetric CO2 adsorption/desorption cycling experiments. Several measurements converge on ~7 wt% monoethanolamine loading which occupies about half of the available pore volume of the sieve. The results suggest that the monoethanolamine is so effectively retained by the molecular sieve that, while the amine is effectively immobilized, under both humid and dry process streams the monoethanolamine is either chemically or sterically hindered and is unable to react measurable quantities of CO2.

  20. Algorithmes et architectures pour ordinateurs quantiques supraconducteurs

    NASA Astrophysics Data System (ADS)

    Blais, Alexandre

    Depuis sa formulation, la theorie de l'information a ete basee, implicitement, sur les lois de la physique classique. Une telle formulation est toutefois incomplete puisqu'elle ne tient pas compte de la realite quantique. Au cours des vingt dernieres annees, l'expansion de la theorie de l'information englobant les effets purement quantiques a connu un interet grandissant. La realisation d'un systeme de traitement de l'information quantique, un ordinateur quantique, presente toutefois de nombreux defis. Dans ce document, on s'interesse a differents aspects concernant ces defis. On commence par presenter des concepts algorithmiques comme l'optimisation de calculs quantiques et le calcul quantique geometrique. Par la suite, on s'interesse au design et a differents aspects de l'utilisation de qubits bases sur les jonctions Josephson. En particulier, un nouveau design de qubit supraconducteur est suggere. On presente aussi une approche originale pour l'interaction entre qubits. Cette approche est tres generale puisqu'elle peut etre appliquee a differents designs de qubits. Finalement, on s'interesse a la lecture des qubits supraconducteurs de flux. Le detecteur suggere ici a l'avantage de pouvoir etre decouple du qubit lorsqu'il n'y a pas de mesure en cours.

  1. Headache in Behçet's disease.

    PubMed

    Aykutlu, E; Baykan, B; Akman-Demir, G; Topcular, B; Ertas, M

    2006-02-01

    The aim of this study was to investigate the characteristics of headache in patients with Behçet's disease (BD) seeking neurological consultation. Consecutive patients with BD seen within 1 year at the neuro-Behçet's out-patient clinic were studied using an electronic database according to the classification criteria of the International Headache Society. During a 12-month period 118 BD patients were admitted, and 98 had headaches. Migraine was the most common type of primary headache diagnosed in 45 patients (46.4%) in the whole headache group, followed by tension-type headache (TTH) in 26 cases (26.8%). Thirty-seven patients had secondary headaches mainly due to cerebral venous thrombosis or parenchymal neurological involvement of BD. Of these patients, 15 had both primary and secondary headaches. The primary headaches of 13 patients were exacerbated with systemic BD flare-ups, and four patients had migraine attacks triggered only by systemic BD activation which showed a good response to the treatment of systemic inflammation. The majority of the headaches of patients with BD do not indicate any neurological involvement; they are usually due to migraine or TTH. In a minority of patients, migraine associated with systemic inflammation of BD is notable.

  2. Adolescence et pornographie sur la toile

    PubMed Central

    Haza, Marion

    2012-01-01

    Dans cet article, nous abordons la question de l’accès à la pornographie sur Internet par les adolescents. Nous déclinons plusieurs facettes de ces rencontres: la rencontre «fortuite», quand les adolescents sont confrontés à des images intempestives, des publicités ou spams avec des contenus pornographiques; la rencontre «spectatrice», quand les adolescents cherchent activement des vidéos ou photos mettant en scène la sexualité; et enfin la rencontre «actrice», quand les adolescents se mettent en scène eux-mêmes, seuls ou à plusieurs, de façon pornographique sur le Net. A partir d’exemple, nous réfléchissons aux enjeux de ces rencontres virtuelles précoces de la sexualité adulte par rapport au développement adolescent et à la représentation de leur propre sexualité en construction. PMID:22876261

  3. Commercial Ethyl Glucuronide (EtG) and Ethyl Sulfate (EtS) Testing is Not Vulnerable to Incidental Alcohol Exposure in Pregnant Women.

    PubMed

    Ondersma, Steven J; Beatty, Jessica R; Rosano, Thomas G; Strickler, Ronald C; Graham, Amy E; Sokol, Robert J

    2016-01-02

    Ethyl Glucoronide (EtG) and Ethyl Sulfate (EtS) have shown promise as biomarkers for alcohol and may be sensitive enough for use with pregnant women in whom even low-level alcohol use is important. However, there have been reports of over-sensitivity of EtG and EtS to incidental exposure to sources such as alcohol-based hand sanitizer. Further, few studies have evaluated these biomarkers among pregnant women, in whom the dynamics of these metabolites may differ. This study evaluated whether commercial EtG-EtS testing was vulnerable to high levels of environmental exposure to alcohol in pregnant women. Two separate samples of five nurses-one pregnant and the other postpartum, all of whom reported high levels of alcohol-based hand sanitizer use-provided urine samples before and 4-8 hours after rinsing with alcohol-based mouthwash and using hand sanitizer. The five pregnant nurses provided urine samples before, during, and after an 8-hour nursing shift, during which they repeatedly cleansed with alcohol-based hand sanitizer (mean 33.8 uses). The five postpartum nurses used hand sanitizer repeatedly between baseline and follow-up urine samples. No urine samples were positive for EtG-EtS at baseline or follow-up, despite use of mouthwash and-in the pregnant sample-heavy use of hand sanitizer (mean of 33.8 uses) throughout the 8-hour shift. Current, commercially available EtG-EtS testing does not appear vulnerable to even heavy exposure to incidental sources of alcohol among pregnant and postpartum women.

  4. Commercial Ethyl Glucuronide (EtG) and Ethyl Sulfate (EtS) Testing is not Vulnerable to Incidental Alcohol Exposure in Pregnant Women

    PubMed Central

    Beatty, Jessica R.; Rosano, Thomas G.; Strickler, Ronald C.; Graham, Amy E.; Sokol, Robert J.

    2016-01-01

    Background Ethyl Glucoronide (EtG) and Ethyl Sulfate (EtS) have shown promise as biomarkers for alcohol and may be sensitive enough for use with pregnant women in whom even low-level alcohol use is important. However, there have been reports of over-sensitivity of EtG and EtS to incidental exposure to sources such as alcohol-based hand sanitizer. Further, few studies have evaluated these biomarkers among pregnant women, in whom the dynamics of these metabolites may differ. Objectives This study evaluated whether commercial EtG-EtS testing was vulnerable to high levels of environmental exposure to alcohol in pregnant women. Methods Two separate samples of five nurses—one pregnant and the other postpartum, all of whom reported high levels of alcohol-based hand sanitizer use—provided urine samples before and 4–8 hours after rinsing with alcohol-based mouthwash and using hand sanitizer. The five pregnant nurses provided urine samples before, during, and after an 8-hour nursing shift, during which they repeatedly cleansed with alcohol-based hand sanitizer (mean 33.8 uses). The five postpartum nurses used hand sanitizer repeatedly between baseline and follow-up urine samples. Results No urine samples were positive for EtG-EtS at baseline or follow-up, despite use of mouthwash and—in the pregnant sample—heavy use of hand sanitizer (mean of 33.8 uses) throughout the 8-hour shift. Conclusions/Importance Current, commercially available EtG-EtS testing does not appear vulnerable to even heavy exposure to incidental sources of alcohol among pregnant and postpartum women. PMID:26771303

  5. [TREATMENT DILEMMAS IN BEHÇET'S SYNDROME].

    PubMed

    Zeller, Lior; Ling, Edoard; Abu-Shakra, Mahmoud

    2016-02-01

    Behçet's disease is an inflammatory systemic disorder, characterized by a relapsing and remitting course, it manifests with oral and genital ulcerations, skin lesions, uveitis, vasculitis, central nervous system and gastrointestinal involvement. The main histopathological finding is widespread vasculitis of the arteries and veins. Therapy is variable and depends largely on the severity of the disease and organ involvement. There is common practice to treat with anticoagulation in patients suffering from vessel thrombosis, but there are no control trials to support this tendency. Anticoagulation treatment can cause major bleeding events in patients suffering from aneurysms. In this case report we describe a treatment dilemma in a patient suffering from deep vein thrombosis and pulmonary aneurysms.

  6. Laser femtoseconde, filamentation, nuage et orage

    NASA Astrophysics Data System (ADS)

    Courvoisier, F.; Boutou, V.; Kasparian, J.; Salmon, E.; Méjean, G.; Yu, J.; Wolf, J.-P.

    2005-06-01

    Les applications telles que le contrôle de foudre grâce aux filaments autoguidés générés par un laser femtoseconde nécessitent de propager un tel filament à travers des aérosols de gouttes d'eau. Nous montrons qu'un filament survit à son interaction avec une goutte de diamètre comparable au sien (95 μ m), ainsi qu'à des nuages d'épaisseur optique 3,2, soit 5% de transmission. Cette transmission est permise par la présence d'un “bain de photons” autour du filament. Ce bain forme un réservoir contenant une part importante de l'énergie du faisceau, en équilibre avec le filament, et favorisant son alimentation.

  7. L'Assurance Vieillesse et Survivants (AVS)

    SciT

    Monod, Elisabeth; Girard, Philippe

    2009-12-09

    Series HR Seminar (Preparation à la retraite - 2009 - Preparing for retirement). Situation particuliere des fonctionnaires internationaux: Tant qu'ils travaillent pour une Organisation Internationale, ils sont exonere de l' AVS suisse (pour les ressortissants suisses uniquement a partir du moment ou ils sont affilies a la caisse des pensions; Des la cessation d'activitie, perte du statut et par consequent assujettissement obligatoire a l' AVS. [Special situation of international civil servants: As long as they work for an International Organization, they are exempt from the Swiss SIA (for Swiss nationals only from the moment they are affiliated to the pensionmore » fund; loss of status and therefore compulsory liability to the AVS.]« less

  8. L'Assurance Vieillesse et Survivants (AVS)

    Monod, Elisabeth; Girard, Philippe

    2018-05-24

    Series HR Seminar (Preparation à la retraite - 2009 - Preparing for retirement). Situation particuliere des fonctionnaires internationaux: Tant qu'ils travaillent pour une Organisation Internationale, ils sont exonere de l' AVS suisse (pour les ressortissants suisses uniquement a partir du moment ou ils sont affilies a la caisse des pensions; Des la cessation d'activitie, perte du statut et par consequent assujettissement obligatoire a l' AVS. [Special situation of international civil servants: As long as they work for an International Organization, they are exempt from the Swiss SIA (for Swiss nationals only from the moment they are affiliated to the pension fund; loss of status and therefore compulsory liability to the AVS.

  9. The Australian experiment with ETS-V

    NASA Technical Reports Server (NTRS)

    Vogel, Wolfhard J.; Goldhirsh, Julius; Hase, Yoshihiro

    1989-01-01

    Land-mobile satellite propagation measurements were implemented at L Band (1.5 GHz) in South-Eastern Australia during an 11 day period in October 1988. Transmissions (CW) from both the Japanese ETS-5 and INMARSAT Pacific geostationary satellites were accessed. Previous measurements in this series were performed at both L Band (1.5 GHz) and UHF (870 MHz) in Central Maryland, North-Central Colorado, and the southern United States. The objectives of the Australian campaign were to expand the data base acquired in the U.S. to another continent, to validate a U.S. derived empirical model for estimating the fade distribution, to establish the effects of directive antennas, to assess the isolation between co- and cross-polarized transmissions, to derive estimates of fade as well as non-fade durations, and to evaluate diversity reception. All these objectives were met.

  10. Validation of ET maps derived from MODIS imagery

    NASA Astrophysics Data System (ADS)

    Hong, S.; Hendrickx, J. M.; Borchers, B.

    2005-12-01

    In previous work we have used the New Mexico Tech implementation of the Surface Energy Balance Algorithm for Land (SEBAL-NMT) for the generation of ET maps from LandSat imagery. Comparison of these SEBAL ET estimates versus ET ground measurements using eddy covariance showed satisfactory agreement between the two methods in the heterogeneous arid landscape of the Middle Rio Grande Basin. The objective of this study is to validate SEBAL ET estimates obtained from MODIS imagery. The use of MODIS imagery is attractive since MODIS images are available at a much higher frequency than LandSat images at no cost to the user. MODIS images have a pixel size in the thermal band of 1000x1000 m which is much coarser than the 60x60 m pixel size of LandSat 7. This large pixel size precludes the use of eddy covariance measurements for validation of ET maps derived from MODIS imagery since the eddy covariance measurement is not representative of a 1000x1000 m MODIS pixel. In our experience, a typical foot print of an ET rate measured by eddy covariance on a clear day in New Mexico around 11 am is less than then thousand square meters or two orders of magnitude smaller than a MODIS thermal pixel. Therefore, we have validated ET maps derived from MODIS imagery by comparison with up-scaled ET maps derived from LandSat imagery. The results of our study demonstrate: (1) There is good agreement between ET maps derived from LandSat and MODIS images; (2) Up-scaling of LandSat ET maps over the Middle Rio Grande Basin produces ET maps that are very similar to ET maps directly derived from MODIS images; (3) ET maps derived from free MODIS imagery using SEBAL-NMT can provide reliable regional ET information for water resource managers.

  11. The caspase-generated cleavage product of Ets-1 p51 and Ets-1 p27, Cp17, induces apoptosis.

    PubMed

    Choul-Li, Souhaila; Tulasne, David; Aumercier, Marc

    2016-11-04

    The transcription factor Ets-1 is involved in various physiological processes and invasive pathologies. Human Ets-1 exists under three isoforms: p51, the predominant full-length isoform, p42 and p27, shorter alternatively spliced isoforms. We have previously demonstrated that Ets-1 p51, but not the spliced variant Ets-1 p42, is processed by caspases in vitro and during apoptosis. However, the caspase cleavage of the second spliced variant Ets-1 p27 remains to investigate. In the present study, we demonstrate that Ets-1 p27 is a cleavage substrate of caspases. We show that Ets-1 p27 is processed in vitro by caspase-3, resulting in three C-terminal fragments Cp20, Cp17 and Cp14. Similarly, Ets-1 p27 was cleaved during apoptotic cell death induced by anisomycin, producing fragments consistent with those observed in in vitro cleavage assay. These fragments are generated by cleavage at three sites located in the exon VII-encoded region of Ets-1 p27. As a functional consequences, Cp17 fragment, the major cleavage product generated during apoptosis, induced itself apoptosis when transfected into cells. Our results show that Ets-1 p27 is cleaved in the same manner as Ets-1 p51 within the exon VII-encoded region, thus generating a stable C-terminal fragment that induces cell death by initiating apoptosis. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Molecular profiling of ETS and non‐ETS aberrations in prostate cancer patients from northern India

    PubMed Central

    Kunju, Lakshmi P.; Carskadon, Shannon L.; Pandey, Swaroop K.; Singh, Geetika; Pradeep, Immanuel; Tandon, Vini; Singhai, Atin; Goel, Apul; Amit, Sonal; Agarwal, Asha; Dinda, Amit K.; Seth, Amlesh; Tsodikov, Alexander; Chinnaiyan, Arul M.; Palanisamy, Nallasivam

    2015-01-01

    Abstract BACKGROUND Molecular stratification of prostate cancer (PCa) based on genetic aberrations including ETS or RAF gene‐rearrangements, PTEN deletion, and SPINK1 over‐expression show clear prognostic and diagnostic utility. Gene rearrangements involving ETS transcription factors are frequent pathogenetic somatic events observed in PCa. Incidence of ETS rearrangements in Caucasian PCa patients has been reported, however, occurrence in Indian population is largely unknown. The aim of this study was to determine the prevalence of the ETS and RAF kinase gene rearrangements, SPINK1 over‐expression, and PTEN deletion in this cohort. METHODS In this multi‐center study, formalin‐fixed paraffin embedded (FFPE) PCa specimens (n = 121) were procured from four major medical institutions in India. The tissues were sectioned and molecular profiling was done using immunohistochemistry (IHC), RNA in situ hybridization (RNA‐ISH) and/or fluorescence in situ hybridization (FISH). RESULTS ERG over‐expression was detected in 48.9% (46/94) PCa specimens by IHC, which was confirmed in a subset of cases by FISH. Among other ETS family members, while ETV1 transcript was detected in one case by RNA‐ISH, no alteration in ETV4 was observed. SPINK1 over‐expression was observed in 12.5% (12/96) and PTEN deletion in 21.52% (17/79) of the total PCa cases. Interestingly, PTEN deletion was found in 30% of the ERG‐positive cases (P = 0.017) but in only one case with SPINK1 over‐expression (P = 0.67). BRAF and RAF1 gene rearrangements were detected in ∼1% and ∼4.5% of the PCa cases, respectively. CONCLUSIONS This is the first report on comprehensive molecular profiling of the major spectrum of the causal aberrations in Indian men with PCa. Our findings suggest that ETS gene rearrangement and SPINK1 over‐expression patterns in North Indian population largely resembled those observed in Caucasian population but differed from Japanese and Chinese PCa patients

  13. Modelisation des emissions de particules microniques et nanometriques en usinage

    NASA Astrophysics Data System (ADS)

    Khettabi, Riad

    La mise en forme des pieces par usinage emet des particules, de tailles microscopiques et nanometriques, qui peuvent etre dangereuses pour la sante. Le but de ce travail est d'etudier les emissions de ces particules pour fins de prevention et reduction a la source. L'approche retenue est experimentale et theorique, aux deux echelles microscopique et macroscopique. Le travail commence par des essais permettant de determiner les influences du materiau, de l'outil et des parametres d'usinage sur les emissions de particules. E nsuite un nouveau parametre caracterisant les emissions, nomme Dust unit , est developpe et un modele predictif est propose. Ce modele est base sur une nouvelle theorie hybride qui integre les approches energetiques, tribologiques et deformation plastique, et inclut la geometrie de l'outil, les proprietes du materiau, les conditions de coupe et la segmentation des copeaux. Il ete valide au tournage sur quatre materiaux: A16061-T6, AISI1018, AISI4140 et fonte grise.

  14. La participation des enfants et des adolescents à la boxe

    PubMed Central

    Purcell, Laura K; LeBlanc, Claire MA

    2012-01-01

    RÉSUMÉ Des milliers de garçons et de filles de moins de 19 ans font de la boxe en Amérique du Nord. Même si la boxe comporte des avantages pour ceux qui y participent, y compris l’exercice, l’autodiscipline et la confiance en soi, le sport lui-même favorise et récompense des coups délibérés à la tête et au visage. Les personnes qui font de la boxe risquent de subir des blessures à la tête, au visage et au cou, y compris des traumatismes neurologiques chroniques et même fatals. Les commotions cérébrales sont l’une des principales blessures causées par la boxe. En raison du risque de blessures crâniennes et faciales, la Société canadienne de pédiatrie et l’American Academy of Pediatrics s’opposent vigoureusement à la boxe comme activité sportive pour les enfants et les adolescents. Ces organismes recommandent que les médecins s’élèvent contre la boxe auprès des jeunes et les encouragent à participer à d’autres activités dans lesquelles les coups intentionnels à la tête ne constituent pas un élément essentiel du sport.

  15. Can weighing lysimeter ET represent surrounding field ET well enough to test flux station measurements of daily and sub-daily ET?

    NASA Astrophysics Data System (ADS)

    Evett, Steven R.; Schwartz, Robert C.; Howell, Terry A.; Louis Baumhardt, R.; Copeland, Karen S.

    2012-12-01

    Weighing lysimeters and neutron probes (NP) are both used to determine the change in soil water storage needed to solve for evapotranspiration (ET) using the soil water balance equation. We compared irrigated cotton ET determined using two large (3 × 3 × 2.4-m deep) weighing lysimeters and eight NP soil water profiles located outside the lysimeters in cotton fields during the BEAREX08 field campaign (see [16] Evett et al., 2012). The objectives were to (i) determine if lysimeter-based ET fluxes were representative of those from the fields, designated NE and SE, in which the lysimeters were centered, and (ii) investigate different methods of computing the soil water balance using NP data. Field fluxes were determined from the soil water balance using neutron probe measurements of change in profile water content storage. Fluxes of ET from the SE lysimeter were representative of those from the field throughout the season and can be used with reasonable certainty for comparisons of ET fluxes and energy balance closure derived from Bowen ratio (BR) and eddy covariance (EC) measurements whose footprints lay in the SE field. Comparisons of ET fluxes from EC and BR systems to those from the NE lysimeter should consider that NE lysimeter fluxes were up to 18% larger than those from the NE field during the period of rapid vegetative growth. This was due to plants on the lysimeter having greater height and width than those in the field. Nevertheless, the data from this and companion studies documents substantial underestimation of crop ET by EC stations under the conditions of BEAREX08. Comparison of zero flux plane (ZFP) and simple soil water balance methods of calculating ET from NP data showed them to be equivalent in this study; and for the ZFP method, the depth of the control volume should be determined by the depth at which the hydraulic gradient reverses, not by the depth of calculated minimum flux. If supported by a sufficiently dense and widespread network of deep

  16. Neuro-Behçet syndrome.

    PubMed

    Saip, Sabahattin; Akman-Demir, Gulsen; Siva, Aksel

    2014-01-01

    Behçet syndrome (BS) is an idiopathic chronic relapsing multisystem vascular-inflammatory disease of unknown origin. As the disease affects many organs and systems and shows a wide range of clinical manifestations and presentations, it is prefereable to call Behçet's a syndrome (BS) rather than a disease. Nervous system involvement, known as "neuro-BS" (NBS), is seen in about 5-10% of all cases. Clinical and imaging evidence suggests that primary neurologic involvement in BS may be subclassified into two major forms: the first, which is seen in the majority of patients, may be characterized as a vascular-inflammatory central nervous system disease with focal or multifocal parenchymal involvement, mostly presenting with a subacute brainstem syndrome and hemiparesis (intra-axial NBS); the other, which has few symptoms and a better neurologic prognosis, may be caused by isolated cerebral venous sinus thrombosis and intracranial hypertension (extra-axial NBS), occurring in 10-20% of the cases. These two types are rarely seen in the same individual, and their pathogenesis is likely to be different. Isolated behavioral syndromes and peripheral nervous system involvement are rare, whereas a vascular type headache is relatively common and independent from neurologic involvement. Neurologic complications secondary to systemic involvement of BS, as well as neurologic complications related to BS treatments are considered as secondary neurologic involvement of the syndrome. The core histopathologic phenomenon seems to be a vasculitic involvement in some cases, and low-grade chronic nonspecific inflammation in others. As the neurologic involvement in this syndrome is so heterogeneous, it is difficult to predict its course and prognosis, and its response to treatment. Currently, treatment options for NBS are limited to attack therapies with high-dose intravenous methylprednisolone followed by a prolonged oral taper, symptomatic management, and generally the use of azathioprine

  17. Ustekinumab for Behçet's disease.

    PubMed

    Mirouse, Adrien; Barete, Stéphane; Monfort, Jean-Benoît; Resche-Rigon, Matthieu; Bouyer, Anne-Sophie; Comarmond, Cloé; Sène, Damien; Domont, Fanny; Ferfar, Yasmina; Cacoub, Patrice; Saadoun, David

    2017-08-01

    To evaluate the efficacy and safety of ustekinumab in the treatment of oral ulcers (OU) in patients with Behçet's disease (BD). Prospective study including 14 patients [median age of 39 (34; 41) years, with 71% of men] fulfilling criteria of the International Study Group for BD and with active OU resistant to colchicine. Patients received ustekinumab 90 mg (n = 11) or 45 mg (n = 3) subcutaneously at inclusion, at week 4, and every 12 weeks. The primary efficacy endpoint was the proportion of patients with complete response (CR), defined as no oral ulcer, at week 12. At week 12, 64% were in CR, 21% in partial response and 14% non-responders. The median number of OU decreased from 2 [2; 4] to 1 [0; 1.25] (p = 0.0005) at week 12. Mean change from baseline to week 12 of Behçet's syndrome activity score (BSAS) was 22.8 ± 0.3 (p = 0.01). The median daily corticosteroids dose decreased from 12.5 (10; 16.3) to 5 [5; 10] mg/day (p = 0.02). Three patients reported headaches, leading to discontinuation of ustekinumab in one case. After a median follow-up of 7 [3; 12] months, 10 (71%) patients were still receiving ustekinumab and four (28%) experienced a relapse. Decreased levels of circulating IL-17 and IL-12 [median [IQR]; 3.9 [1.6; 10.6] vs. 29.2 [25.2; 42.7] pg/ml, and 29.4 [23.1; 33.3] vs. 56.1 [51.1; 64.4] pg/ml, p = 0.008 for both] were observed under ustekinumab, respectively. Ustekinumab seems to be efficient and safe for patient with BD and refractory OU although relapses are frequent. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. [Innovative ET cover system and its hydrologic evaluation].

    PubMed

    Liu, Chuan-shun; Cai, Jun-xiong; Wang, Jing-zhai; Rong, Yu

    2010-07-01

    The evapotranspiration (ET) cover system,as an alternative cover system of landfill, has been used in many remediation projects since 2003. It is an inexpensive, practical,and easily maintained biological system, but is mainly favorable in arid and semiarid sites due to limited water-holding capacity of the single loam layer and limited transpiration of grass. To improve the effectiveness of percolation control, an innovative scheme of ET was suggested in this paper: (1) a clay liner was added under the single loam layer to increase the water-holding capacity; (2) combined vegetation consisting of shrub and grass was used to replace the grass cover. Hydrologic evaluation of conventional cover,ET cover and the innovative ET cover under the same condition was performed using the computer program HELP, which showed the performance of the innovative ET cover is obviously superior to that of ET cover and conventional cover.

  19. Biotherapies in Behçet's disease.

    PubMed

    Comarmond, Cloé; Wechsler, Bertrand; Bodaghi, Bahram; Cacoub, Patrice; Saadoun, David

    2014-07-01

    Behçet's disease (BD) is a systemic large-vessel vasculitis characterized by a wide clinical spectrum including recurrent oral and genital ulcerations, uveitis, vascular, neurological, articular, renal and gastrointestinal manifestations. Therapeutic management of BD depends on the clinical presentation and organ involved. Although colchicine, nonsteroidal antiinflammatory agents and topical treatments with corticosteroids are often sufficient for mucocutaneous and joint involvements, more aggressive approach with immunosuppressive agents is warranted for severe manifestations such as posterior uveitis, retinal vasculitis, vascular, and neurological and gastrointestinal involvements. However, some patients still have refractory disease, relapse, sight threatening eye disease, or irreversible organ damage. Recent improvements in the understanding of the pathogenic mechanisms have led to the identification of potential targets and future biological therapies for BD. In contrast to current non-specific immunosuppressive agents, the emergence of biotherapies provides the possibility of interfering with specific pathogenic pathways. Novel targeted biotherapies might be used in the future for BD. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. [Treatment of Behçet's disease].

    PubMed

    Comarmond, C; Wechsler, B; Cacoub, P; Saadoun, D

    2014-02-01

    Behçet's disease (BD) is a systemic large-vessel vasculitis characterized by a wide clinical spectrum including recurrent oral and genital ulcerations, uveitis, vascular, neurological, articular, and gastrointestinal manifestations. Therapeutic management of BD depends on the clinical presentation and organ involved. Although colchicine, non-steroidal anti-inflammatory agents and topical treatments with corticosteroids are often sufficient for mucocutaneous and joint involvement, a more aggressive approach with immunosuppressive agents is warranted for severe manifestations such as posterior uveitis, retinal vasculitis, vascular, neurological and gastrointestinal involvement. However, some patients still have refractory disease, relapses, sight threatening eye disease, or irreversible organ damage. Recent improvements in the understanding of the pathogenic mechanisms have led to the identification of potential targets and future therapies for BD. In contrast to current non-specific immunosuppressive agents, the emergence of immunomodulatory drugs provides the possibility of interfering with specific pathogenic pathways. Novel targeted immunosuppressive therapies might be used in the future for BD. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

  1. [Perifolliculitis capitis abscedens et suffodiens (case report)].

    PubMed

    Tsiskarishvili, N V; Katsitadze, A G; Tsiskarishvili, Ts I

    2012-04-01

    Perifolliculitis capitis abscedens et suffodiens (PCAS) is rare chronic, suppurative and inflammatory scalp disease. Its aetiology and pathogenesis is not completely understood. The treatment is usually difficult and often disappointing. We report a case of 25-year-old male who presented with tender, fluctuant nodules and abscesses, with draining pus and patchy alopecia on his scalp for 3 years. A skin biopsy from scalp lesions revealed features that are characteristic of perifolliculitis. Initially, the patient was treated with periodic incision and drainage of the scalp abscesses. The answer was very poor. When admitted to our department, isotretinoin was started at daily dose of 30 mg, because initially his cholesterol and triglyceride levels were mildly increased. When dose was reduced to 10 mg the levels of cholesterol and triglyceride remained normal. A response to treatment was excellent and rapid. The treatment of PCAS represents usually difficulties and frustration for both the patient and the physician. A long course of isotretinoin can be considered as one of the most effective treatment for PCAS.

  2. Eosinophils in lichen sclerosus et atrophicus.

    PubMed

    Keith, Phillip J; Wolz, Michael M; Peters, Margot S

    2015-10-01

    The classic histopathologic features of lichen sclerosus et atrophicus (LS) include lymphoplasmacytic inflammation below a zone of dermal edema and sclerosis. The presence of eosinophils in LS has received little attention, but the finding of tissue eosinophils, particularly eosinophilic spongiosis in LS, has been suggested as a marker for the coexistence of autoimmune bullous disease or allergic contact dermatitis (or both). We sought to determine whether the histopathologic presence of dermal eosinophils or eosinophilic spongiosis (or both) in biopsies from patients with LS is associated with autoimmune bullous disease, autoimmune connective tissue disease or allergic contact dermatitis. A retrospective review of the histopathology and medical records of 235 patients with LS who were evaluated from June 1992 to June 2012 was performed. Sixty-nine patients (29%) had eosinophils on histopathology. Among patients with associated diseases, a statistically significant association between the eosinophil cohort and the cohort without eosinophils was not detected. The importance of eosinophils is uncertain, but our data suggest that the finding of tissue eosinophils alone is not sufficient to prompt an extensive workup for additional diagnoses. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  3. Space Shuttle ET Friction Stir Weld Machines

    NASA Technical Reports Server (NTRS)

    Thompson, Jack M.

    2003-01-01

    NASA and Lockheed-Martin approached the FSW machine vendor community with a specification for longitudinal barrel production FSW weld machines and a shorter travel process development machine in June of 2000. This specification was based on three years of FSW process development on the Space Shuttle External Tank alloys, AL2 195-T8M4 and AL22 19-T87. The primary motivations for changing the ET longitudinal welds from the existing variable polarity Plasma Arc plasma weld process included: (1) Significantly reduced weld defect rates and related reduction in cycle time and uncertainty; (2) Many fewer process variables to control (5 vs. 17); (3) Fewer manufacturing steps; (4) Lower residual stresses and distortion; (5) Improved weld strengths, particularly at cryogenic temperatures; (6) Fewer hazards to production personnel. General Tool was the successful bidder. The equipment is at this writing installed and welding flight hardware. This paper is a means of sharing with the rest of the FSW community the unique features developed to assure NASA/L-M of successful production welds.

  4. Developing a charging system for a nursing specialty: ET nursing.

    PubMed

    Lowery, G E; Gage, J; Lowenstein, A

    1994-05-01

    Because of limited resources and economic constraints, justifying the existence of ET nurses has become an economic challenge for hospitals and nurses. To justify the role of the ET nurse, a charging system for enterostomal therapy was developed at a corporate, for-profit hospital. Three months after implementation, an evaluation of the system demonstrated that revenue was generated in excess of the ET nurse's salary.

  5. Aerodynamic heating to representative SRB and ET protuberances

    NASA Technical Reports Server (NTRS)

    Engel, C. D.; Lapointe, J. K.

    1979-01-01

    Heating data and data scaling methods which can be used on representative solid rocket booster and external tank (ET) protuberances are described. Topics covered include (1) ET geometry and heating points; (2) interference heating test data (51A); (3) heat transfer data from tests FH-15 and FH-16; (4) individual protuberance data; and (5) interference heating of paint data from test IH-42. A set of drawings of the ET moldline and protuberances is included.

  6. Transformer Specification Language: A System for Generating Analyzers and Its Applications

    DTIC Science & Technology

    2011-01-01

    like to thank present and former colleagues in PL group, Evan Driscoll, Aditya Thakur, Matt Elder, Tushar Sharma , Prathmesh Prabhu, Tycho Andersen, Emma...Robert Cohn, Robert Muth, Harish Patil, Artur Klauser, Geoff Lowney, Steven Wallace, Vijay Janapa Reddi, and Kim Hazelwood. Pin: building customized

  7. Signatures of DNA target selectivity by ETS transcription factors

    PubMed Central

    Kim, Hye Mi

    2017-01-01

    ABSTRACT The ETS family of transcription factors is a functionally heterogeneous group of gene regulators that share a structurally conserved, eponymous DNA-binding domain. DNA target specificity derives from combinatorial interactions with other proteins as well as intrinsic heterogeneity among ETS domains. Emerging evidence suggests molecular hydration as a fundamental feature that defines the intrinsic heterogeneity in DNA target selection and susceptibility to epigenetic DNA modification. This perspective invokes novel hypotheses in the regulation of ETS proteins in physiologic osmotic stress, their pioneering potential in heterochromatin, and the effects of passive and pharmacologic DNA demethylation on ETS regulation. PMID:28301293

  8. Signatures of DNA target selectivity by ETS transcription factors.

    PubMed

    Poon, Gregory M K; Kim, Hye Mi

    2017-05-27

    The ETS family of transcription factors is a functionally heterogeneous group of gene regulators that share a structurally conserved, eponymous DNA-binding domain. DNA target specificity derives from combinatorial interactions with other proteins as well as intrinsic heterogeneity among ETS domains. Emerging evidence suggests molecular hydration as a fundamental feature that defines the intrinsic heterogeneity in DNA target selection and susceptibility to epigenetic DNA modification. This perspective invokes novel hypotheses in the regulation of ETS proteins in physiologic osmotic stress, their pioneering potential in heterochromatin, and the effects of passive and pharmacologic DNA demethylation on ETS regulation.

  9. Application of ET-Kyoto solution in clinical lung transplantation.

    PubMed

    Omasa, Mitsugu; Hasegawa, Seiki; Bando, Toru; Hanaoka, Nobuharu; Yoshimura, Takashi; Nakamura, Takayuki; Wada, Hiromi

    2004-01-01

    We have developed a new organ preservation solution called extracellular-type trehalose-containing Kyoto (ET-Kyoto) solution. ET-Kyoto solution has been applied in clinical lung transplantation. The patient was a 49-year-old woman with diffuse panbronchiolitis. She underwent bilateral lobar lung transplantation from living donors. Each lobe was flushed with ET-Kyoto solution. After reperfusion, PaO(2) with inhalation of 100% oxygen was more than 500 Torr. Posttransplantation course was uneventful. Despite the relatively short ischemic time of this case report, ET-Kyoto solution may be feasible and safely applied in clinical lung transplantation.

  10. Algorithmes et architectures pour ordinateurs quantiques supraconducteurs

    NASA Astrophysics Data System (ADS)

    Blais, A.

    2003-09-01

    Algorithms and architectures for superconducting quantum computers Since its formulation, information theory was based, implicitly, on the laws of classical physics. Such a formulation is however incomplete because it does not take into account quantum reality. During the last twenty years, expansion of theory information to include quantum effects has known growing interest. The practical realization of a system for quantum data processing system, a quantum computer, presents however many challenges. In this book, we are interested in various aspects of these challenges. We start by presenting algorithmic concepts like optimization of quantum computations and geometric quantum computation. We then consider various designs and aspects of qubits based on Josephson junctions. In particular, an original approach to the interaction between superconducting qubits is presented. This approach is very general since it can be applied to various designs of qubits. Finally, we are interested in read-out of the superconductic flux qubits. The detector suggested here has the advantage that it is possible to uncouple it from the qubit when no measurement is in progress. Depuis sa formulation, la théorie de l'information a été basée, implicitement, sur les lois de la physique classique. Une telle formulation est toutefois incomplète puisqu'elle ne tient pas compte de la réalité quantique. Au cours des vingt dernières années, l'expansion de la théorie de l'information, de façon à englober les effets purement quantiques, a connu un intérêt grandissant. La réalisation d'un système de traitement de l'information quantique, un ordinateur quantique, présente toutefois de nombreux défis. Dans cet ouvrage, on s'intéresse à différents aspects concernant ces défis. On commence par présenter des concepts algorithmiques comme l'optimisation de calculs quantiques et le calcul quantique géométrique. Par la suite, on s'intéresse à différents designs et aspects de l

  11. Mortality in Behçet's disease.

    PubMed

    Saadoun, D; Wechsler, B; Desseaux, K; Le Thi Huong, D; Amoura, Z; Resche-Rigon, M; Cacoub, P

    2010-09-01

    To report the long-term mortality in patients with Behçet's disease (BD). A cohort of 817 patients fulfilling the international criteria for BD from a single center in France were analyzed for causes of death, the standardized mortality ratio (SMR), and the factors associated with mortality. Among the 817 patients with BD, 41 (5%) died after a median followup of 7.7 years, of whom 95.1% were male. The mean ± SD age at death was 34.8 ± 11.9 years. Main causes of death included major vessel disease (mainly, arterial aneurysm and Budd-Chiari syndrome) (43.9%), cancer and malignant hemopathy (14.6%), central nervous system involvement (12.2%), and sepsis (12.2%). The mortality rate at 1 year and 5 years was 1.2% and 3.3%, respectively. There was an increased mortality among patients ages 15-24 years (SMR 2.99, 95% confidence interval [95% CI] 1.54-5.39) and those ages 25-34 years (SMR 2.90, 95% CI 1.80-4.49) as compared with age-and sex-matched healthy controls. The mortality decreased in patients older than age 35 years (SMR 1.23, 95% CI 0.75-1.92). In multivariate analyses, male sex (hazard ratio [HR] 4.94, 95% CI 1.53-16.43), arterial involvement (HR 2.51, 95% CI 1.07-5.90), and a high number of BD flares (HR 2.37, 95% CI 1.09-5.14) were independently associated with the risk of mortality. The overall mortality in our BD cohort was 5% after a median followup of 7.7 years. Male sex, arterial involvement, and the number of flares were associated with mortality in BD.

  12. How well can wave runup be predicted? comment on Laudier et al. (2011) and Stockdon et al. (2006)

    Plant, Nathaniel G.; Stockdon, Hilary F.

    2015-01-01

    Laudier et al. (2011) suggested that there may be a systematic bias error in runup predictions using a model developed by Stockdon et al. (2006). Laudier et al. tested cases that sampled beach and wave conditions that differed from those used to develop the Stockdon et al. model. Based on our re-analysis, we found that in two of the three Laudier et al. cases observed overtopping was actually consistent with the Stockdon et al. predictions. In these cases, the revised predictions indicated substantial overtopping with, in one case, a freeboard deficit of 1 m. In the third case, the revised prediction had a low likelihood of overtopping, which reflected a large uncertainty due to wave conditions that included a broad and bi-modal frequency distribution. The discrepancy between Laudier et al. results and our re-analysis appear to be due, in part, to simplifications made by Laudier et al. when they implemented a reduced version of the Stockdon et al. model.

  13. Comment on RamaRao et al. [1995] and LaVenue et al. [1995

    Cooley, Richard L.; Hill, Mary C.

    2000-01-01

    A method for stochastic modeling of groundwater flow systems using a combination of pilot point parameterization and conditional simulation was presented by RamaRao et. al [1995] and LaVenue et. al [1995]. (We will collectively term these two papers RLMM and term the method developed in RLMM the CS method here.) RLMM (pp. 478-479) state that the CS method is intended to provide a frequency distribution of possible alternative spatial transmissivity T distributions that (1) are statistically similar to the observed T distribution, (2) are equally likely given the calibration data, and (3) closely reproduce the measured pressures. The frequency distribution of transmissivities is then used to form frequency distribution of derived functions, such as travel times, which are summarized in the form of uncertainty measures, such as (RLMM, p. 512) "confidence (or tolerance) intervals," on the actual values, which in the case of travels times, are values that could occur sometime in the future (RLMM, p.513). Cooley [2000] analyzes the RLMM method using linearization and bootstrap theory and concludes that that the method can yield accurate uncertainty estimates but only under some limited circumstances.  In this comment we use Cooley's analysis to critique the method. We also identify and discuss some statements made my by RLMM about model calibration and their methodology that appear to be misleading. It is unusual to comment on a paper so long after publication. Subsequent work has expanded the method of RLMM, and the method was used advantageously in the testing documented by Zimmerman et. al [1998], so it is clear the method has significant strengths. We go back to the 1995 papers for this comment, however, because they display most clearly the methodological difficulties with which we are concerned. 

  14. Evaluation of the ET2000 guardrail end treatment.

    DOT National Transportation Integrated Search

    2004-01-01

    The objectives of this study were to monitor and report the performance of the ET2000 guardrail end treatment design in traffic crashes. The involved vehicle was inspected when available. : Data for a total of 135 collisions involving the ET2000 were...

  15. Deriving hourly evapotranspiration (ET) rates with SEBS: A lysimetric evaluation

    Numerous energy balance (EB) algorithms have been developed to use remote sensing data for mapping evapotranspiration (ET) on a regional basis. Adopting any single or combination of these models for an operational ET remote sensing program requires a thorough evaluation. The Surface Energy Balance S...

  16. E-mail et Web: Pour une Navigation Sans Risque

    SciT

    Dellabella, Sebastien

    2010-06-28

    Présentation orale en français, support visuel en anglais. À travers des exemples concrets, vous consoliderez vos connaissances et pourrez ainsi réajuster vos habitudes concernant l’utilisation sécurisée de votre boîte e-mail et de votre navigateur Web.

  17. The Test Collection at ETS: 34 Years and Still Growing

    ERIC Educational Resources Information Center

    McQuillen, Karen

    2009-01-01

    This essay updates the two articles that were previously published in the Winter 1975/1976 and 1984 issues respectively of "Education Libraries," and featured the Educational Testing Service (ETS) Test Collection. At the time of the writing of the 1975/1976 article, the collection was known as The ETS Test Collection. However, since the collection…

  18. The utility of covariances: a response to Ranta et al

    J.E. Houlahan; K. Cottenie; G.S. Cumming; D.J. Currie; C.S. Findlay; U. Gaedke; P. Legendre; J.J. Magnuson; B.H. McArdle; R.D. Stevens; I.P. Woiwod; S.M. Wondzell

    2008-01-01

    In an earlier publication (Houlahan et al. 2007) we reviewed trends in population covariances within communities across a range of long-term empirical data sets. We used these results to argue that compensatory dynamics are rare in natural communities. Ranta et al. (2008) explored interspecific interactions in a simulated environment and showed that 'negative...

  19. Contacts de langues et representations (Language Contacts and Representations).

    ERIC Educational Resources Information Center

    Matthey, Marinette, Ed.

    1997-01-01

    Essays on language contact and the image of language, entirely in French, include: "Representations 'du' contexte et representations 'en' contexte? Eleves et enseignants face a l'apprentissage de la langue" ("Representations 'of' Context or Representations 'in' Context? Students and Teachers Facing Language Learning" (Laurent…

  20. 78 FR 21428 - Royce Focus Trust, Inc., et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ...] Royce Focus Trust, Inc., et al.; Notice of Application April 4, 2013. AGENCY: Securities and Exchange.... Applicants: Royce Focus Trust, Inc. (``RFT''), Royce Value Trust, Inc. (``RVT''), Royce Micro-Cap Trust, Inc... prior order (``Prior Order'').\\1\\ \\1\\ Royce Global Trust, Inc., et al., Investment Company Act Release...

  1. Hearing loss in Behçet syndrome.

    PubMed

    Bakhshaee, Mehdi; Mahdi, Bakhshaee; Ghasemi, Mohammad Mehdi; Mehdi, Ghasemi Mohammad; Hatef, Mohammad Reza; Reza, Hatef Mohammad; Talebmehr, Mahdieh; Mahdieh, Talebmehr; Shakeri, Mohammad Taghi; Taghi, Shakeri Mohammad

    2007-09-01

    To determine the prevalence and characteristics of hearing loss in Behçet syndrome. This study included 27 patients with Behçet syndrome and 35 sex-and age-matched controls. A complete audiological evaluation was performed. The average pure-tone audiograms from both groups showed a statistically significant hearing loss in the Behçet group. Sixteen patients (59.26%) showed some degrees of sensorineural hearing loss (SNHL), with the high-frequency type (4, 8, 10, and 12 kHz) being the most common pattern (93.75%). Hearing loss was the fourth most common manifestation. Although the patient's age, sex, and the duration of the disease were not related to hearing loss, there was a significant correlation between a negative pathergy test and hearing loss in patients with Behçet syndrome. We should consider audiovestibular involvement in Behçet syndrome as a common finding.

  2. Characterizing an "uncharacteristics" ETS event in northern Cascadia

    Wang, K.; Dragert, H.; Kao, H.; Roeloffs, E.

    2008-01-01

    GPS and borehole strainmeter data allowed the detection and model characterization of a slow slip event in northern Cascadia in November 2006 accompanying a brief episode of seismic tremor. The event is much smaller in area and duration than other well-known ETS events in northern Cascadia but is strikingly similar to typical ETS events at the Nankai subduction zone. The 30-45 km depth range and the 2-3 cm slip magnitude as interpreted for this event appear to be common to most ETS events in these two subduction zones, regardless of their sizes. We infer that the Nankai-type small ETS events must be abundant at Cascadia and that ETS event at the two subduction zones are governed by a similar physical process. Copyright 2008 by the American Geophysical Union.

  3. Characterizing an "uncharacteristic" ETS event in northern Cascadia

    Wang, Kelin; Dragert, Herb; Kao, Honn; Roeloffs, Evelyn

    2008-01-01

    GPS and borehole strainmeter data allowed the detection and model characterization of a slow slip event in northern Cascadia in November 2006 accompanying a brief episode of seismic tremor. The event is much smaller in area and duration than other well-known ETS events in northern Cascadia but is strikingly similar to typical ETS events at the Nankai subduction zone. The 30-45 km depth range and the 2-3 cm slip magnitude as interpreted for this event appear to be common to most ETS events in these two subduction zones, regardless of their sizes. We infer that the Nankai-type small ETS events must be abundant at Cascadia and that ETS events at the two subduction zones are governed by a similar physical process.

  4. Analyse conversationnelle et representations sociales: Unite et diversite de L'image du bilinguisme (Conversational Analysis and Social Representations: Unity and Diversity in the Image of Bilingualism).

    ERIC Educational Resources Information Center

    Py, Bernard, Ed.

    2000-01-01

    Articles in this issue include the following: "Representations sociales et discours. Questions epistemologiques et methodologiques" (Social Representations and Discourse. Questions of Epistemology and Methodology); "Aspects theoretiques et methodologiques de la recherche sur le traitement discursif des representations sociales"…

  5. 78 FR 32443 - United States, et al. v. Cinemark Holdings, Inc., et al.; Proposed Final Judgment and Competitive...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ... DEPARTMENT OF JUSTICE Antitrust Division United States, et al. v. Cinemark Holdings, Inc., et al.; Proposed Final Judgment and Competitive Impact Statement Notice is hereby given pursuant to the Antitrust Procedures and Penalties Act, 15 U.S.C. 16(b)-(h), that a proposed Final Judgment, Hold Separate Stipulation and Order and Competitive Impact...

  6. 76 FR 5439 - United States, et al. v. Comcast Corp., et al.; Proposed Final Judgment and Competitive Impact...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... Vol. 76 Monday, No. 20 January 31, 2011 Part III Department of Justice Antitrust Division United States, et al. v. Comcast Corp., et al.; Proposed Final Judgment and Competitive Impact Statement; Notice #0;#0;Federal Register / Vol. 76 , No. 20 / Monday, January 31, 2011 / Notices#0;#0; [[Page 5440

  7. Les effets des interfaces sur les proprietes magnetiques et de transport des multicouches nickel/iron et cobalt/silver

    NASA Astrophysics Data System (ADS)

    Veres, Teodor

    Cette these est consacree a l'etude de l'evolution structurale des proprietes magnetiques et de transport des multicouches Ni/Fe et nanostructures a base de Co et de l'Ag. Dans une premiere partie, essentiellement bibliographique, nous introduisons quelques concepts de base relies aux proprietes magnetiques et de transport des multicouches metalliques. Ensuite, nous presentons une breve description des methodes d'analyse des resultats. La deuxieme partie est consacree a l'etude des proprietes magnetiques et de transport des multicouches ferromagnetiques/ferromagnetiques Ni/Fe. Nous montrerons qu'une interpretation coherente de ces proprietes necessite la prise en consideration des effets des interfaces. Nous nous attacherons a mettre en evidence, a evaluer et a etudier les effets de ces interfaces ainsi que leur evolution, et ce, suite a des traitements thermiques tel que le depot a temperature elevee et l'irradiation ionique. Les analyses correlees de la structure et de la magnetoresistance nous permettront d'emettre des conclusions sur l'influence des couches tampons entre l'interface et le substrat ainsi qu'entre les couches elles-memes sur le comportement magnetique des couches F/F. La troisieme partie est consacree aux systemes a Magneto-Resistance Geante (MRG) a base de Co et Ag. Nous allons etudier l'evolution de la microstructure suite a l'irradiation avec des ions Si+ ayant une energie de 1 MeV, ainsi que les effets de ces changements sur le comportement magnetique. Cette partie debutera par l'analyse des proprietes d'une multicouche hybride, intermediaire entre les multicouches et les materiaux granulaires. Nous analyserons a l'aide des mesures de diffraction, de relaxation superparamagnetique et de magnetoresistance, les evolutions structurales produites par l'irradiation ionique. Nous etablirons des modeles qui nous aideront a interpreter les resultats pour une serie des multicouches qui couvrent un large eventail de differents comportements magnetiques

  8. Headache in Behçet's syndrome: review of literature and NYU Behçet's syndrome center experience.

    PubMed

    Vishwanath, Vijay; Wong, Ericka; Crystal, Sara C; Robbins, Matthew S; Filopoulos, Maria; Lipton, Richard B; Yazici, Yusuf; Kister, Ilya

    2014-09-01

    Headache, a common and disabling symptom in Behçet's syndrome, may be associated with a variety of neurologic syndromes and ocular inflammation, or may present as an isolated feature. Our objective is to describe the various neurologic and ocular syndromes of Behçet's syndrome of which headache is a symptom, and to review the features of isolated headaches in Behçet's. We also report results of a study of headache in Behçet's syndrome patients who are followed at NYU Hospital for Joint Diseases, the first study of its kind in North American patients, and the first to document prevalence of both episodic and chronic daily headache in Behçet's.

  9. N° 341-Diagnostic et prise en charge de la torsion annexielle chez les filles, les adolescentes et les femmes adultes.

    PubMed

    Kives, Sari; Gascon, Suzy; Dubuc, Élise; Van Eyk, Nancy

    2017-02-01

    Passer en revue les connaissances scientifiques actuelles et formuler des recommandations relatives au diagnostic et à la prise en charge de la torsion annexielle chez les filles, les adolescentes et les femmes adultes. L'étude porte sur les facteurs de risque, la précision diagnostique, les options de prise en charge et les issues de la torsion annexielle. RéSULTATS: Nous avons examiné les études publiées en faisant des recherches dans MEDLINE, Embase, CINAHL et la Bibliothèque Cochrane à l'aide d'une terminologie contrôlée et de mots-clés appropriés (« adnexal torsion », « ovarian torsion »). Nous avons limité les résultats aux revues systématiques, aux essais contrôlés aléatoires, aux essais cliniques contrôlés et aux études d'observation. Nous avons refait les recherches de façon régulière et intégré de nouvelles données à la directive jusqu'en décembre 2014. Nous avons également étudié la littérature grise (non publiée) trouvée sur les sites Web d'organismes d'évaluation des technologies de la santé et d'autres organismes connexes, dans des collections de directives cliniques et dans des registres d'essais cliniques, et obtenue auprès d'associations nationales et internationales de médecins spécialistes. Les résultats ont été examinés et évalués par le comité CANPAGO de la Société des obstétriciens et gynécologues du Canada (SOGC), sous la direction des auteures principales. Les recommandations ont été classées selon les critères établis par le Groupe d'étude canadien sur les soins de santé préventifs. AVANTAGES, DéSAVANTAGES ET COûTS: L'application de la directive devrait aider les praticiens à adopter une approche de diagnostic et de prise en charge optimale en matière de torsion annexielle, à réduire au minimum les effets néfastes et à améliorer l'issue qui attend les patientes. La présente directive a été évaluée et approuvée par le Comité de pratique - gynécologie de la SOGC

  10. Correction to Smith et al. (2013).

    PubMed

    Smith, Carl D; Piasecki, Christopher C; Weera, Marcus; Olszewicz, Joshua; Lonstein, Joseph S

    2015-08-01

    Reports an error in "Noradrenergic alpha-2 receptor modulators in the ventral bed nucleus of the stria terminalis: Effects on anxiety behavior in postpartum and virgin female rats" by Carl D. Smith, Christopher C. Piasecki, Marcus Weera, Joshua Olszewicz and Joseph S. Lonstein (Behavioral Neuroscience, 2013[Aug], Vol 127[4], 582-597). Table 2 should have used the ratio of 5HIAA/serotonin - rather than the inverse - as the indicator of serotonin turnover. Using the correct ratio, differences in serotonin turnover between the postpartum and virgin females are: BSTv - 1.11 0.06 vs 0.79 0.11 (t 2.57, p 0.05); BSTd - 1.01 0.07 vs 0.68 0.11 (t 2.58, p 0.05). That is, contrary to what was originally reported, postpartum females had higher serotonin turnover in both subregions of the BST compared to virgins. The penultimate sentence in the abstract noting serotonin turnover in mothers has been corrected in the online version of this article. (The following abstract of the original article appeared in record 2013-22430-001.) Emotional hyperreactivity can inhibit maternal responsiveness in female rats and other animals. Maternal behavior in postpartum rats is disrupted by increasing norepinephrine release in the ventral bed nucleus of the stria terminalis (BSTv) with the α2-autoreceptor antagonist, yohimbine, or the more selective α2-autoreceptor antagonist, idazoxan (Smith et al., 2012). Because high noradrenergic activity in the BSTv can also increase anxiety-related behaviors, increased anxiety may underlie the disrupted mothering of dams given yohimbine or idazoxan. To assess this possibility, anxiety-related behaviors in an elevated plus maze were assessed in postpartum rats after administration of yohimbine or idazoxan. It was further assessed if the α2-autoreceptor agonist clonidine (which decreases norepinephrine release) would, conversely, reduce dams' anxiety. Groups of diestrous virgins were also examined. It was found that peripheral or intra-BSTv yohimbine

  11. Synthese et Caracterisation de Nanocomposites d'Argile et de Graphene Formes a Partir de Precurseurs Organiques =

    NASA Astrophysics Data System (ADS)

    Boussaboun, Zakariae

    Les mineraux d'argile sont des catalyseurs possibles pour la formation du graphene a partir de precurseurs organiques, comme le saccharose. Les argiles sont abondantes, securitaires et economiques pour la formation du graphene. L'objectif principal de ce memoire est de demontrer qu'il est possible de synthetiser un materiau hybride contenant de l'argile et du graphene. La preparation de ces materiaux carbones a base de l'argile (bentonite et cloisite) et le saccharose a ete realisee selon deux methodes. La premiere methode est faite en trois etapes : 1) periode de contact entre l'argile et la source de carbone dans un environnement humide, 2) infiltration de la matiere carbonee et transformation au four a micro-onde, 3) chauffage a 750°C sous azote pour obtenir des materiaux carbones. Par contre la deuxieme methode est faite en deux etapes, sans micro-onde, et avec une augmentation de la quantite de source de carbone (saccharose et alginate). La caracterisation du materiau a permis de suivre les reactions de transformation de la source de carbone vers le graphene. Cette caracterisation a ete faite par la spectroscopie IRTF et Raman, l'analyse thermogravimetrique (TGA), la surface specifique (methode BET) et le microscope electronique a balayage (MEB). La conductivite electrique a ete mesuree par un spectrometre dielectrique et en fonction de la pression appliquee avec un multimetre. Le materiau realise etait incorpore dans une matrice avec un polyethylene a basse densite pour avoir un polymere avec des caracteristiques specifiques. La conductivite thermique a ete ensuite mesuree suivant la norme ASTM E1530. L'echantillon realise avec la deuxieme methode avec une proportion de bentonite pour 5 proportions de saccharose (M2 B1 : S5) signale la possibilite de produire des materiaux de graphene a partir de ressources naturelles. La surface specifique a considerablement augmente de (75,88 m2/g) pour bentonite non traiter a (139,76 m2/g) pour l'echantillon (M2 B1 : S5

  12. Closeup view of an External Tank (ET) Attach Ring undergoing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Close-up view of an External Tank (ET) Attach Ring undergoing preparations in the Processing Building of the Rotation Processing and Surge Facility at Kennedy Space Center. After preparations are complete the ET Attach Ring will be mated to the top of the Aft Motor Segment. The most prominent features in this view are the ET/Solid Rocket Booster Struts in the center and left in the view and the Aft Integrated Electronics Assembly located on the right side if the ring in this view. - Space Transportation System, Solid Rocket Boosters, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

  13. Large area nuclear particle detectors using ET materials

    NASA Technical Reports Server (NTRS)

    1987-01-01

    The purpose of this SBIR Phase 1 feasibility effort was to demonstrate the usefulness of Quantex electron-trapping (ET) materials for spatial detection of nuclear particles over large areas. This demonstration entailed evaluating the prompt visible scintillation as nuclear particles impinged on films of ET materials, and subsequently detecting the nuclear particle impingement information pattern stored in the ET material, by means of the visible-wavelength luminescence produced by near-infrared interrogation. Readily useful levels of scintillation and luminescence outputs are demonstrated.

  14. Pharmacological endothelin receptor interaction does not occur in veins from ET(B) receptor deficient rats.

    PubMed

    Thakali, Keshari; Galligan, James J; Fink, Gregory D; Gariepy, Cheryl E; Watts, Stephanie W

    2008-07-01

    Heterodimerization of G-protein coupled receptors can alter receptor pharmacology. ET A and ET B receptors heterodimerize when co-expressed in heterologous expression lines. We hypothesized that ET A and ET B receptors heterodimerize and pharmacologically interact in vena cava from wild-type (WT) but not ET B receptor deficient (sl/sl) rats. Pharmacological endothelin receptor interaction was assessed by comparing ET-1-induced contraction in rings of rat thoracic aorta and thoracic vena cava from male Sprague Dawley rats under control conditions, ET A receptor blockade (atrasentan, 10 nM), ET B receptor blockade (BQ-788, 100 nM) or ET B receptor desensitization (Sarafotoxin 6c, 100 nM) and ET A plus ET B receptor blockade or ET A receptor blockade plus ET B receptor desensitization. In addition, similar pharmacological ET receptor antagonism experiments were performed in rat thoracic aorta and vena cava from WT and sl/sl rats. ET A but not ET B receptor blockade or ET B receptor desensitization inhibited aortic and venous ET-1-induced contraction. In vena cava but not aorta, when ET B receptors were blocked (BQ-788, 100 nM) or desensitized (S6c, 100 nM), atrasentan caused a greater inhibition of ET-1-induced contraction. Vena cava from WT but not sl/sl rats exhibited similar pharmacological ET receptor interaction. Immunocytochemistry was performed on freshly dissociated aortic and venous vascular smooth muscle cells to determine localization of ET A and ET B receptors. ET A and ET B receptors qualitatively co-localized more strongly to the plasma membrane of aortic compared to venous vascular smooth muscle cells. Our data suggest that pharmacological ET A and ET B receptor interaction may be dependent on the presence of functional ET B receptors and independent of receptor location.

  15. A Response from Golden Rule to "ETS on 'Golden Rule'".

    ERIC Educational Resources Information Center

    Rooney, J. Patrick

    1987-01-01

    This article rebuts comments by G. R. Anrig (1987) on the Settlement Agreement that resolved the racial discrimination suit brought by the Golden Rule Insurance Company against the Educational Testing Service (ETS) and the Illinois Department of Insurance. (TJH)

  16. 76 FR 35245 - Country Investors Life Assurance Company, et al.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-16

    ... Life Assurance Company, et al. June 9, 2011. AGENCY: Securities and Exchange Commission (the.... Applicants: COUNTRY Investors Life Assurance Company (the ``Company''), COUNTRY Investors Variable Life Account (the ``Life Account'') and COUNTRY Investors Variable Annuity Account (the ``Annuity Account...

  17. 75 FR 51239 - University of Massachusetts Amherst, et al.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-19

    ... DEPARTMENT OF COMMERCE International Trade Administration University of Massachusetts Amherst, et... Commerce, 14th and Constitution Avenue., NW., Washington, DC. Docket Number: 10-044. Applicant: University.... Applicant: Appalachian State University, Boone, NC 28608. Instrument: Electron Microscope. Manufacturer...

  18. 75 FR 9867 - University of Pittsburgh, et al

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... DEPARTMENT OF COMMERCE International Trade Administration University of Pittsburgh, et al.; Notice of Consolidated Decision on Applications for Duty-Free Entry of Electron Microscopes This is a...: University of Pittsburgh, Pittsburgh, PA 15260. Instrument: Electron Microscope. Manufacturer: JEOL, Ltd...

  19. Electronic Transmutation (ET): Chemically Turning One Element into Another.

    PubMed

    Zhang, Xinxing; Lundell, Katie A; Olson, Jared K; Bowen, Kit H; Boldyrev, Alexander I

    2018-03-08

    The concept of electronic transmutation (ET) depicts the processes that by acquiring an extra electron, an element with the atomic number Z begins to have properties that were known to only belong to its neighboring element with the atomic number Z+1. Based on ET, signature compounds and chemical bonds that are composed of certain elements can now be designed and formed by other electronically transmutated elements. This Minireview summarizes the recent developments and applications of ET on both the theoretical and experimental fronts. Examples on the ET of Group 13 elements into Group 14 elements, Group 14 elements into Group 15 elements, and Group 15 elements into Group 16 elements are discussed. Compounds and chemical bonding composed of carbon, silicon, germanium, phosphorous, oxygen and sulfur now have analogues using transmutated boron, aluminum, gallium, silicon, nitrogen, and phosphorous. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Genetics Home Reference: Behçet disease

    MedlinePlus

    ... of Behçet disease has been reported in northern Turkey, where the disorder affects up to 420 in ... Updated Pages Reviewed : June 2017 Published : June 19, 2018 The resources on this site should not be ...

  1. La manucure et la pédicure dans la ville de Ouagadougou (Burkina Faso): pratiques et risqué

    PubMed Central

    Korsaga-Somé, Nina; Andonaba, Jean Baptiste; Ouédraogo, Muriel Sidnoma; Tapsoba, Gilbert Patrice; Ilboudo, Léopold; Savadogo, Cérina; Barro-Traoré, Fatou; Niamba, Pascal; Traoré, Adama

    2016-01-01

    La manucure-pédicure est l'ensemble des soins esthétiques des mains, des pieds et des ongles. Au Burkina Faso, l'usage des produits de manucure-pédicure, les techniques utilisées ainsi que les risques encourus restent méconnus. L'objectif de notre étude était d’évaluer la pratique de la manucure-pédicure dans la ville de Ouagadougou. Nous avons mené une étude transversale descriptive de décembre 2010 à novembre 2012 incluant tout les praticiens ayant au moins six mois d'expérience dans l'activité et les clients présents sur les lieux au moment de l'enquête. Nous avons interrogé au total 313 praticiens et 313 clients. L’âge moyen des praticiens était de 19 ans et celui des clients de 32,2 ans. Les praticiens fixes étaient en majorité des femmes (96,87%), ceux mobiles surtout des hommes (68,37%), et 64,53% des clients étaient des femmes. Le pourcentage de praticiens n'ayant pas reçu de formation professionnelle était de 93,92%. 29,7% des praticiens faisaient tremper les instruments pendant au moins dix minutes dans de l'eau de javel; 75,71% savaient que l'utilisation de certains outils étaient dangereux et 26,51% étaient avaient présenté des effets secondaires. Parmi les clients, 40,25% savaient que le matériel utilisé comportait des risques et 30,35% avaient été victimes d'accidents. Les soins de manucure et de pédicure se font dans les salons de coiffure par des coiffeuses non formées à l'exercice de la profession La provenance et la composition des produits n'est pas connues. Des produits non recommandés sont utilisés (shampooing pour trempage des pieds, lame de rasoir et ciseaux pour raclage des pieds). Le recours à la manucure et/ou pédicure est parfois nécessaire mais cela ne doit pas faire perdre de vue les risques encourus. Une sensibilisation des clients et une formation des praticiens semblent nécessaires pour minimiser les risques. PMID:27642448

  2. Etude numerique et experimentale de la reponse vibro-acoustique des structures raidies a des excitations aeriennes et solidiennes

    NASA Astrophysics Data System (ADS)

    Mejdi, Abderrazak

    Les fuselages des avions sont generalement en aluminium ou en composite renforces par des raidisseurs longitudinaux (lisses) et transversaux (cadres). Les raidisseurs peuvent etre metalliques ou en composite. Durant leurs differentes phases de vol, les structures d'avions sont soumises a des excitations aeriennes (couche limite turbulente : TBL, champs diffus : DAF) sur la peau exterieure dont l'energie acoustique produite se transmet a l'interieur de la cabine. Les moteurs, montes sur la structure, produisent une excitation solidienne significative. Ce projet a pour objectifs de developper et de mettre en place des strategies de modelisations des fuselages d'avions soumises a des excitations aeriennes et solidiennes. Tous d'abord, une mise a jour des modeles existants de la TBL apparait dans le deuxieme chapitre afin de mieux les classer. Les proprietes de la reponse vibro-acoustique des structures planes finies et infinies sont analysees. Dans le troisieme chapitre, les hypotheses sur lesquelles sont bases les modeles existants concernant les structures metalliques orthogonalement raidies soumises a des excitations mecaniques, DAF et TBL sont reexamines en premier lieu. Ensuite, une modelisation fine et fiable de ces structures est developpee. Le modele est valide numeriquement a l'aide des methodes des elements finis (FEM) et de frontiere (BEM). Des tests de validations experimentales sont realises sur des panneaux d'avions fournis par des societes aeronautiques. Au quatrieme chapitre, une extension vers les structures composites renforcees par des raidisseurs aussi en composites et de formes complexes est etablie. Un modele analytique simple est egalement implemente et valide numeriquement. Au cinquieme chapitre, la modelisation des structures raidies periodiques en composites est beaucoup plus raffinee par la prise en compte des effets de couplage des deplacements planes et transversaux. L'effet de taille des structures finies periodiques est egalement pris en

  3. Support Provided to the External Tank (ET) Project on the Use of Statistical Analysis for ET Certification Consultation Position Paper

    NASA Technical Reports Server (NTRS)

    Null, Cynthia H.

    2009-01-01

    In June 2004, the June Space Flight Leadership Council (SFLC) assigned an action to the NASA Engineering and Safety Center (NESC) and External Tank (ET) project jointly to characterize the available dataset [of defect sizes from dissections of foam], identify resultant limitations to statistical treatment of ET as-built foam as part of the overall thermal protection system (TPS) certification, and report to the Program Requirements Change Board (PRCB) and SFLC in September 2004. The NESC statistics team was formed to assist the ET statistics group in August 2004. The NESC's conclusions are presented in this report.

  4. Behçet's syndrome patients exhibit specific microbiome signature.

    PubMed

    Consolandi, Clarissa; Turroni, Silvia; Emmi, Giacomo; Severgnini, Marco; Fiori, Jessica; Peano, Clelia; Biagi, Elena; Grassi, Alessia; Rampelli, Simone; Silvestri, Elena; Centanni, Manuela; Cianchi, Fabio; Gotti, Roberto; Emmi, Lorenzo; Brigidi, Patrizia; Bizzaro, Nicola; De Bellis, Gianluca; Prisco, Domenico; Candela, Marco; D'Elios, Mario M

    2015-04-01

    Behçet syndrome is a systemic inflammatory condition characterized by muco-cutaneous and ocular manifestations, with central nervous system, vascular and/or gastro-intestinal involvement. The association of microbiota with Behçet syndrome has not been shown yet. Our work was aimed to compare the gut microbiota structure and the profiles of short-chain fatty acids production in Behçet syndrome patients and healthy control relatives. Here, we compared the fecal microbiota of 22 patients with Behçet syndrome and that of 16 healthy co-habiting controls, sharing the same diet and lifestyle by pyrosequencing of the V3-V4 hypervariable regions of the 16 rDNA gene and biochemical analyses. Our analyses showed significant differences in gut microbiota between Behçet patients and healthy cohabitants. In particular we found that Behçet's patients were significantly depleted in the genera Roseburia and Subdoligranulum. Roseburia showed a relative abundance value of 10.45±6.01% in healthy relatives and 4.97±5.09% in Behçet's patients, and Subdoligranulum, which reached a relative abundance of 3.28±2.20% in healthy controls, was only at 1.93±1.75% of abundance in Behçet's patients. Here we report, for the first time, that a peculiar dysbiosis of the gut microbiota is present in patients with Behçet syndrome and this corresponds to specific changes in microbiome profile. A significant decrease of butyrate production (P=0.0033) in Behçet's patients was demonstrated. Butyrate is able to promote differentiation of T-regulatory cells, and consequently the results obtained prompt us to speculate that a defect of butyrate production might lead to both reduced T-reg responses and activation of immuno-pathological T-effector responses. Altogether, our results indicate that both a peculiar dysbiosis of the gut microbiota and a significant decrease of butyrate production are present in patients with Behçet syndrome. Published by Elsevier B.V.

  5. RIP-ET: A riparian evapotranspiration package for MODFLOW-2005

    Maddock, Thomas; Baird, Kathryn J.; Hanson, R.T.; Schmid, Wolfgang; Ajami, Hoori

    2012-01-01

    A new evapotranspiration package for the U.S. Geological Survey's groundwater-flow model, MODFLOW, is documented. The Riparian Evapotranspiration Package (RIP-ET) provides flexibility in simulating riparian and wetland transpiration not provided by the Evapotranspiration (EVT) or Segmented Function Evapotranspiration (ETS1) Packages for MODFLOW 2005. This report describes how the RIP-ET package was conceptualized and provides input instructions, listings and explanations of the source code, and an example. Traditional approaches to modeling evapotranspiration (ET) processes assume a piecewise linear relationship between ET flux and hydraulic head. The RIP-ET replaces this traditional relationship with a segmented, nonlinear dimensionless curve that reflects the eco-physiology of riparian and wetland ecosystems. Evapotranspiration losses from these ecosystems are dependent not only on hydraulic head, but on the plant types present. User-defined plant functional groups (PFGs) are used to elucidate the interaction between plant transpiration and groundwater conditions. Five generalized plant functional groups based on transpiration rates, plant rooting depth, and water tolerance ranges are presented: obligate wetland, shallow-rooted riparian, deep-rooted riparian, transitional riparian and bare ground/open water. Plant functional groups can be further divided into subgroups (PFSGs) based on plant size, density or other characteristics. The RIP-ET allows for partial habitat coverage and mixtures of plant functional subgroups to be present in a single model cell. RIP-ET also distinguishes between plant transpiration and bare-ground evaporation. Habitat areas are designated by polygons; each polygon can contain a mixture of PFSGs and bare ground, and is assigned a surface elevation. This process requires a determination of fractional coverage for each of the plant functional subgroups present in a polygon to account for the mixture of coverage types and resulting

  6. Etude RICH Nursing. Plus de connaissances et de preuves scientifiques

    PubMed Central

    SCHUBERT, MARIA

    2009-01-01

    L’importance et la validité des résultats de l’étude RICH-Nursing* ont été récemment mises en cause par certains milieux, ce qui a provoqué certaines incertitudes chez les infirmières. Les auteurs reviennent sur l’impact actuel de cette étude et évoquent les perspectives d’avenir. PMID:25221376

  7. E-mail et Web: Pour une Navigation Sans Risque

    Dellabella, Sebastien

    2018-04-27

    Présentation orale en français, support visuel en anglais. À travers des exemples concrets, vous consoliderez vos connaissances et pourrez ainsi réajuster vos habitudes concernant l’utilisation sécurisée de votre boîte e-mail et de votre navigateur Web.

  8. De l'importance des orbites periodiques: Detection et applications

    NASA Astrophysics Data System (ADS)

    Doyon, Bernard

    L'ensemble des Orbites Periodiques Instables (OPIs) d'un systeme chaotique est intimement relie a ses proprietes dynamiques. A partir de l'ensemble (en principe infini) d'OPIs cachees dans l'espace des phases, on peut obtenir des quantites dynamiques importantes telles les exposants de Lyapunov, la mesure invariante, l'entropie topologique et la dimension fractale. En chaos quantique (i.e. l'etude de systemes quantiques qui ont un equivalent chaotique dans la limite classique), ces memes OPIs permettent de faire le pont entre le comportement classique et quantique de systemes non-integrables. La localisation de ces cycles fondamentaux est un probleme complexe. Cette these aborde dans un premier temps le probleme de la detection des OPIs dans les systemes chaotiques. Une etude comparative de deux algorithmes recents est presentee. Nous approfondissons ces deux methodes afin de les utiliser sur differents systemes dont des flots continus dissipatifs et conservatifs. Une analyse du taux de convergence des algorithmes est aussi realisee afin de degager les forces et les limites de ces schemes numeriques. Les methodes de detection que nous utilisons reposent sur une transformation particuliere de la dynamique initiale. Cette astuce nous a inspire une methode alternative pour cibler et stabiliser une orbite periodique quelconque dans un systeme chaotique. Le ciblage est en general combine aux methodes de controle pour stabiliser rapidement un cycle donne. En general, il faut connaitre la position et la stabilite du cycle en question. La nouvelle methode de ciblage que nous presentons ne demande pas de connaitre a priori la position et la stabilite des orbites periodiques. Elle pourrait etre un outil complementaire aux methodes de ciblage et de controle actuelles.

  9. Ion transport in the microporous titanosilicate ETS-10.

    PubMed

    Wei, Ta-Chen; Hillhouse, Hugh W

    2006-07-20

    Impedance spectroscopy was used to investigate ion transport in the microporous crystalline framework titanosilicate ETS-10 in the frequency range from 1 Hz to 10 MHz. These data were compared to measured data from the microporous aluminosilicate zeolite X. Na-ETS-10 was found to have a lower activation energy for ion conduction than that of NaX, 58.5 kJ/mol compared to 66.8 kJ/mol. However, the dc conductivity and ion hopping rate for Na-ETS-10 were also lower than NaX. This was found to be due to the smaller entropy contribution in Na-ETS-10 because of its high cation site occupancy. This was verified by ion exchanging Na(+) with Cu(2+) in both microporous frameworks. This exchange decreases the cation site occupancy and reduces correlation effects. The exchanged Cu-ETS-10 was found to have both lower activation energy and higher ionic conductivity than CuX. Zeolite X has the highest ion conductivity among the zeolites, and thus the data shown here indicate that ETS-10 has more facile transport of higher valence cations which may be important for ion-exchange, environmental remediation of radionucleotides, and nanofabrication.

  10. Constrained variability of modeled T:ET ratio across biomes

    NASA Astrophysics Data System (ADS)

    Fatichi, Simone; Pappas, Christoforos

    2017-07-01

    A large variability (35-90%) in the ratio of transpiration to total evapotranspiration (referred here as T:ET) across biomes or even at the global scale has been documented by a number of studies carried out with different methodologies. Previous empirical results also suggest that T:ET does not covary with mean precipitation and has a positive dependence on leaf area index (LAI). Here we use a mechanistic ecohydrological model, with a refined process-based description of evaporation from the soil surface, to investigate the variability of T:ET across biomes. Numerical results reveal a more constrained range and higher mean of T:ET (70 ± 9%, mean ± standard deviation) when compared to observation-based estimates. T:ET is confirmed to be independent from mean precipitation, while it is found to be correlated with LAI seasonally but uncorrelated across multiple sites. Larger LAI increases evaporation from interception but diminishes ground evaporation with the two effects largely compensating each other. These results offer mechanistic model-based evidence to the ongoing research about the patterns of T:ET and the factors influencing its magnitude across biomes.

  11. Item Response Theory. Research Report. ETS RR-13-28. ETS R&D Scientific and Policy Contributions Series. ETS SPC-13-05

    ERIC Educational Resources Information Center

    Carlson, James E.; von Davier, Matthias

    2013-01-01

    Few would doubt that ETS researchers have contributed more to the general topic of item response theory (IRT) than individuals from any other institution. In this report, we briefly review most of those contributions, dividing them into sections by decades of publication, beginning with early work by Fred Lord and Bert Green in the 1950s and…

  12. Evaluating Educational Programs. ETS R&D Scientific and Policy Contributions Series. ETS SPC-11-01. ETS Research Report No. RR-11-15

    ERIC Educational Resources Information Center

    Ball, Samuel

    2011-01-01

    Since its founding in 1947, ETS has conducted a significant and wide-ranging research program that has focused on, among other things, psychometric and statistical methodology; educational evaluation; performance assessment and scoring; large-scale assessment and evaluation; cognitive, developmental, personality, and social psychology; and…

  13. Can weighing lysimeter ET represent surrounding field ET well enough to test flux station measurements of daily and sub-daily ET?

    Weighing lysimeters and neutron probes are two tools used to determine the change in soil water storage that is needed to solve for evapotranspiration (ET) using the soil water balance equation. Errors in the soil water balance due to errors in determination of precipitation and irrigation are commo...

  14. Testing the Storm et al. (2010) meta-analysis using Bayesian and frequentist approaches: reply to Rouder et al. (2013).

    PubMed

    Storm, Lance; Tressoldi, Patrizio E; Utts, Jessica

    2013-01-01

    Rouder, Morey, and Province (2013) stated that (a) the evidence-based case for psi in Storm, Tressoldi, and Di Risio's (2010) meta-analysis is supported only by a number of studies that used manual randomization, and (b) when these studies are excluded so that only investigations using automatic randomization are evaluated (and some additional studies previously omitted by Storm et al., 2010, are included), the evidence for psi is "unpersuasive." Rouder et al. used a Bayesian approach, and we adopted the same methodology, finding that our case is upheld. Because of recent updates and corrections, we reassessed the free-response databases of Storm et al. using a frequentist approach. We discuss and critique the assumptions and findings of Rouder et al. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

  15. Molecular and functional characterization of the promoter of ETS2, the human c-ets-2 gene.

    PubMed Central

    Mavrothalassitis, G J; Watson, D K; Papas, T S

    1990-01-01

    The 5' end of the human c-ets-2 gene, ETS2, was cloned and characterized. The major transcription initiation start sites were identified, and the pertinent sequences surrounding the ETS2 promoter were determined. The promoter region of ETS2 does not possess typical "TATA" and "CAAT" elements. However, this promoter contains several repeat regions, as well as two consensus AP2 binding sites and three putative Sp1 sites. There is also a palindromic region similar to the serum response element of the c-fos gene, located 1400 base pairs (bp) upstream from the first major transcription initiation site. A G + C-rich sequence (GC element) with dyad symmetry can be seen in the ETS2 promoter, immediately following an unusually long (approximately 250-bp) polypurine-polypyrimidine tract. A series of deletion fragments from the putative promoter region were ligated in front of the bacterial chloramphenicol acetyltransferase gene and tested for activity following transfection into HeLa cells. The 5' boundary of the region needed for maximum promoter activity was found to be 159 bp upstream of the major initiation site. This region of 159 bp contains putative binding sites for transcription factors Sp1 and AP2 (one for each), the GC element, one small forward repeat, one inverted repeat, and half of the polypurine-pyrimidine tract. The promoter of ETS2 (within the polypyrimidine tract) serves to illustrate an alternative structure that may be present in genes with "TATA-less" promoters. Images PMID:2405393

  16. Dip-dependent variations in LFE duration during ETS events

    NASA Astrophysics Data System (ADS)

    Chestler, S.; Creager, K.; Ghosh, A.

    2015-12-01

    Using data from the Array of Arrays experiment, we create a new, more spatially complete catalog of LFEs beneath the Olympic Peninsula, WA. Using stacked waveforms produced by stacking 1-minute windows of data from each array over the slowness with the greatest power [Ghosh et al., 2012], we pick out peaks in tremor activity that are consistent over multiple arrays. These peaks are potential LFE detections. Fifteen-second windows of raw data centered on each peak are scanned through time. If the waveform repeats, the detection is used as a new LFE family. Template waveforms for each family are created by stacking all windows that correlate with the initial detection. During an ETS event, activity at a given point on the plate interface (i.e. the activity of an LFE family) typically lasts for 3.5 (downdip) to 5 days (updip). Activity generally begins with a flurry of LFEs lasting 8 hours (downdip) to 20 hours (updip) followed by many short bursts of activity separated by 5 hours or more. Updip families have more bursts (5-10) than downdip families (2-5 bursts). The later bursts often occur during times of encouraging tidal shear stress, while the initial flurries have no significant correlation with tides. While updip LFE families are more active during ETS events than downdip families, they seldom light up between ETS events, which only occur every 12-14 months. On the other hand, downdip LFE families are active much more frequently during the year; the most down-dip families exhibit activity every week or so. Because updip families are rarely active between ETS events, it is possible that little stress is released updip during inter-ETS time periods. Hence during ETS events more stress needs to be released updip than downdip, consistent with the longer-duration activity of updip LFE families.

  17. Dispositifs semi-conducteurs pour biodetection photonique et imagerie hyperspectrale

    NASA Astrophysics Data System (ADS)

    Lepage, Dominic

    La creation d'un microsysteme d'analyse biochimique, capable de livrer des diagnostics preliminaires sur la quantification d'elements pathogenes, est un defi multidisciplinaire ayant un impact potentiel important sur la majorite des activites humaines en sante et securite. En effet, un dispositif integre, peu dispendieux et livrant des resultats facilement interpretables, permettrait une vulgarisation des capacites de biodetection a travers differents domaines d'applications societaires et industriels. Le present document se concentre sur l'integration monolithique d'une methode de biocaracterisation dans le but de generer un transducteur miniaturise et efficace, element central d'un microsysteme de detection. Le projet de recherche ici presente vise l'etude de l'applicabilite d'un capteur plasmonique integre par l'entremise de nanostructures semi-conductrices aux proprietes quantiques et luminescentes. L'approche presentee est globale; c'est-a-dire qu'on vise a repondre aux questions fondamentales impliquant la comprehension des phenomenes photoniques, le developpement et la fabrication des dispositifs, les methodes de caracterisations possibles ainsi que l'application d'un transducteur SPR integre a la biodetection. En d'autres termes : dans quelles circonstances et comment un transducteur plasmonique integre doit-il etre realise pour l'application a la detection delocalisee d'elements pathogenes? Dans le but d'engendrer un instrument simple a l'echelle de l'usager, l'integration de la connaissance a l'echelle du design est donc effectuee. Ainsi, des capteurs plasmoniques monolithiques sont concus a l'aide de modeles theoriques ici presentes. Un instrument de mesure hyperspectrale conjuguee permettant de cartographier directement la relation de dispersion des plasmons diffractes a ete construit et teste. Cet instrument est employe a la cartographie d'elements de diffusion. Finalement, une demonstration du fonctionnement du dispositif, appliquee a la

  18. Differential diagnosis and management of Behçet syndrome.

    PubMed

    Ambrose, Nicola L; Haskard, Dorian O

    2013-02-01

    Behçet syndrome (also known as Behçet disease) is a rare condition that is associated with considerable morbidity. Cases of Behçet syndrome have been reported worldwide, but the highest prevalence occurs in countries that border the ancient Silk Route, such as Turkey and Iran. Although oral ulceration, genital ulceration and eye disease are the classic triad of manifestations, the cardiovascular, gastrointestinal, musculoskeletal and central nervous systems can also be affected. The syndrome is chronic and relapsing with some patients having benign episodes whereas others have more serious complications, including blindness or the rupture of a pulmonary arterial aneurysm. Diagnosing Behçet syndrome, particularly outside of endemic regions, often incurs a considerable delay owing to the rarity of this condition. Furthermore, a paucity exists of data from randomized controlled trials on the optimal therapeutic approaches to use in patients, as well as a lack of informative laboratory surrogate markers to monitor disease progression. This Review discusses the issues surrounding the diagnosis and differential diagnosis of Behçet syndrome and presents the current approaches to managing patients with this complex group of disorders.

  19. Constitutional trisomy 8 and Behçet syndrome.

    PubMed

    Becker, Kristin; Fitzgerald, Oliver; Green, Andrew J; Keogan, Mary; Newbury-Ecob, Ruth; Greenhalgh, Lynn; Withers, Stephen; Hollox, Edward J; Aldred, Patricia M R; Armour, John A L

    2009-05-01

    The characteristic clinical features of constitutional trisomy 8 include varying degrees of developmental delay, joint contractures and deep palmar and plantar creases. There is an established literature, which describes features of Behçet syndrome occurring in phenotypically normal individuals with myelodysplastic syndromes and trisomy 8 in their bone marrow. In this article, we describe four patients with constitutional trisomy 8, all with varying clinical phenotypes, who developed features of Behçet, in particular but not exclusively mucocutaneous ulceration. In addition, we examined gene copy numbers of the variable-number neutrophil defensin genes DEFA1A3 in one of the cases (case 1) and her parents, together with 14 cases of Behçet syndrome in comparison with 121 normal controls. The gene copy number was highest in case 1 (copy number 14) and was also increased in her parents (both copy number 9). However the mean copy number for DEFA1A3 among the 14 Behçet syndrome patients was actually lower (5.1) than among the controls (mean of 6.8 copies). Thus, we conclude that patients with constitutional trisomy 8 and those with trisomy 8 confined to the bone marrow are both at increased risk of developing features of Behçet syndrome. The mechanism may relate to increased chromosome 8 gene dosage with further analysis of candidate genes on chromosome 8 required.

  20. EXAFS and XANES investigation of the ETS-10 microporous titanosilicate.

    PubMed

    Prestipino, C; Solari, P L; Lamberti, C

    2005-07-14

    In this work, we report state-of-the-art analysis of both Ti K-edge high-resolution XANES and EXAFS data collected on the ETS-10 molecular sieve at the GILDA BM8 beamline of the ESRF facility. The interatomic distances and the angles obtained in our EXAFS study are in fair agreement with the single-crystal XRD data of Wang and Jacobson (Chem. Commun. 1999, 973) and with the recent ab initio periodic study of Damin et al. (J. Phys. Chem. B 2004, 108, 1328) Differently from previous EXAFS work (J. Phys. Chem. 1996, 100, 449), our study supports a model of ETS-10 where the Ti atoms are bonded with two equivalent axial oxygen atoms. This model is also able to reproduce the edge and the post-edge region of the XANES spectrum. Conversely, the weak but well-defined pre-edge peak at 4971.3 eV can be explained only by assuming that a fraction of Ti atoms are in a local geometry similar to that of the pentacoordinated Ti sites in the ETS-4 structure. These Ti atoms in ETS-10 should be the terminal of the -Ti-O-Ti-O-Ti- chains, of which the actual number is strongly increased by the high crystal defectivity (Ti vacancies).

  1. Major vessel involvement in Behçet disease.

    PubMed

    Calamia, Kenneth T; Schirmer, Michael; Melikoglu, Melike

    2005-01-01

    Large vessel vasculitis occurs in a subgroup of patients with Behçet disease at high risk for disease-related morbidity and mortality. Recognition of patients at risk, early detection of vasculitis, and the need for aggressive treatment are essential for optimal care of these patients. The authors review the clinical spectrum and management of large vessel problems in Behçet disease, highlighting contributions over the past year. Vasculo-Behçet patients are at risk for multiple vessel-related complications including thromboses, stenoses, occlusions, and aneurysms. A number of factors may contribute to thrombosis in individual cases, but the primary reason for clot seems to reside in the inflammatory process in the arterial wall, still incompletely understood. An appreciation for the challenges in the perioperative period requires the joint efforts of physicians and surgeons, and fuels the study of alternate, less invasive procedures for Behçet patients. Because of earlier recognition, aggressive medical treatment, and novel surgical procedures, the morbidity and mortality of large vessel vasculitis in Behçet disease are beginning to change. In the absence of controlled treatment studies, reports of clinical experience remain an important source of information for clinicians. Identification of patients at risk for vascular complications remains a priority.

  2. Reply. [to the comment by Anderson et al. (1993)

    NASA Technical Reports Server (NTRS)

    Hegg, Dean A.; Ferek, Ronald G.; Hobbs, Peter V.

    1994-01-01

    While Hegg et al. (1993) accepts the criticism of Anderson et al. (1994) in principle, this involves the adoption of an aerosol composition model and the model that they propose to reconcile these observations with the assertion of Charlson et al. (1992) does not agree with many observations, particularly those made over the North Atlantic Ocean. Although the use of a gain factor (i.e. the partial derivative of aerosol mass with respect to the sulfate ion), proposed by Anderson et al., may be valid for particular cases where a proposed composition model really reflects the actual aerosol composition, this procedure is considered questionable in general. The use of sulfate as a tracer for nonsulfate aerosol mass is questionable, because in the present authors' data set, sulfate averaged only about 26% of the dry aerosol mass. The ammonium mass associated with sulfate mass is not analogous to that betwen the oxygen mass and sulfur mass in the sulfate ion. Strong chemical bonds are present between sulfur and oxygen in sulfate, whereas ammonium and sulfate in haze droplets are ions in solution that may or may not be associated with one another. Thus, there is no reason to assume that sulfate will act as a reliable tracer of ammonium mass. Hegg et al. expresses the view that their approach used for estimating sulfate light scattering efficiency is appropriate for the current level of understanding of atmospheric aerosols.

  3. [Industrialization condition and development strategy of Notopterygii Rhizoma et Radix].

    PubMed

    Jiang, Shun-Yuan; Sun, Hui; Wang, Hong-Lan; Ma, Xiao-Jun; Qin, Ji-Hong; Xin, Jun; Sun, Hong-Bing; Du, Jiu-Zhen; Yin, Li

    2017-07-01

    Notopterygii Rhizoma et Radix, the underground part of Notopterygium incisum and N. franchetii, is used as a classical traditional Chinese medicine, and as raw materials for 262 Chinese patent drugs production in 694 pharmaceutical factories currently. It plays an important role in the whole Chinese medicine industry with irreplaceable important economic and social values. However, wild resource of was abruptly depleted, and large-scale artificial cultivation has been inapplicable. In this study, Utilization history and the industrialization status of Notopterygii Rhizoma et Radix were summarized. Resource distribution, ecological suitability of Notopterygii Rhizoma et Radix and core technologies for seeds production, seedling breeding, large-scale cultivation has been reported by current studies, and basic conditions are already available for industrialization production of Notopterygii Rhizoma et Radix. However, there still some key technical problems need to be solved in the further research, and some policy dimensions need to be focused on in the coming industrialization cultivation of Notopterygii Rhizoma et Radix. Copyright© by the Chinese Pharmaceutical Association.

  4. [Standardization of production of process Notopterygii Rhizoma et Radix slices].

    PubMed

    Sun, Zhen-Yang; Wang, Ying-Zi; Nie, Rui-Jie; Zhang, Jing-Zhen; Wang, Si-Yu

    2017-12-01

    Notopterol, isoimperatorin, volatile oil and extract (water and ethanol) were used as the research objects in this study to investigate the effects of different softening method, slice thickness and drying methods on the quality of Notopterygii Rhizoma et Radix slices, and the experimental data were analyzed by homogeneous distance evaluation method. The results showed that different softening, cutting and drying processes could affect the content of five components in Notopterygii Rhizoma et Radix incisum. The best processing technology of Notopterygii Rhizoma et Radix slices was as follows: non-medicinal parts were removed; mildewed and rot as well as moth-eaten parts were removed; washed by the flowing drinking water; stacked in the drug pool; moistening method was used for softening, where 1/8 volume of water was sprayed for every 1 kg of herbs every 2 h; upper part of herbs covered with clean and moist cotton, and cut into thick slices (2-4 mm) after 12 h moistening until appropriate softness, then received blast drying for 4 h at 50 ℃, and turned over for 2 times during the drying. The process is practical and provides the experimental basis for the standardization of the processing of Notopterygii Rhizoma et Radix, with great significance to improve the quality of Notopterygii Rhizoma et Radix slices. Copyright© by the Chinese Pharmaceutical Association.

  5. Global Overexpression of ET-1 Decreases Blood Pressure - A Systematic Review and Meta-Analysis of ET-1 Transgenic Mice.

    PubMed

    Lu, Yong Ping; Tsuprykov, Oleg; Vignon-Zellweger, Nicolas; Heiden, Susi; Hocher, Berthold

    2016-01-01

    ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide. To determine the net effect of these partially counteracting mechanisms on blood pressure, a systematic meta-analysis was performed. Based on the principles of Cochrane systematic reviews, we searched in major literature databases - MEDLINE (PubMed), Embase, Google Scholar, and the China Biological Medicine Database (CBM-disc) - for articles relevant to the topic of the blood pressure phenotype of endothelin-1 transgenic (ET-1+/+) mice from January 1, 1988 to March 31, 2016. Review Manager Version 5.0 (Rev-Man 5.0) software was applied for statistical analysis. In total thirteen studies reported blood pressure data. The meta-analysis of blood pressure data showed that homozygous ET-1 transgenic mice (ET-1+/+ mice) had a significantly lower blood pressure as compared to WT mice (mean difference: -2.57 mmHg, 95% CI: -4.98∼ -0.16, P = 0.04), with minimal heterogeneity (P = 0.86). A subgroup analysis of mice older than 6 months revealed that the blood pressure difference between ET-1+/+ mice and WT mice was even more pronounced (mean difference: -6.19 mmHg, 95% CI: -10.76∼ -1.62, P = 0.008), with minimal heterogeneity (P = 0.91). This meta-analysis provides robust evidence that global ET-1 overexpression in mice lowers blood pressure in an age-dependent manner. Older ET-1+/+ mice have a somewhat more pronounced reduction of blood pressure. © 2016 The Author(s) Published by S. Karger AG, Basel.

  6. Relations de Dispersion et Diffusion des Glueballs et des Mesons dans la Theorie de Jauge U(1)(2+1) Compacte

    NASA Astrophysics Data System (ADS)

    Ahmed, Chaara El Mouez

    Nous avons etudie les relations de dispersion et la diffusion des glueballs et des mesons dans le modele U(1)_{2+1} compact. Ce modele a ete souvent utilise comme un simple modele de la chromodynamique quantique (QCD), parce qu'il possede le confinement ainsi que les etats de glueballs. Par contre, sa structure mathematique est beaucoup plus simple que la QCD. Notre methode consiste a diagonaliser l'Hamiltonien de ce modele dans une base appropriee de graphes et sur reseau impulsion, afin de generer les relations de dispersion des glueballs et des mesons. Pour la diffusion, nous avons utilise la methode dependante du temps pour calculer la matrice S et la section efficace de diffusion des glueballs et des mesons. Les divers resultats obtenus semblent etre en accord avec les travaux anterieurs de Hakim, Alessandrini et al., Irving et al., qui eux, utilisent plutot la theorie des perturbations en couplage fort, et travaillent sur un reseau espace-temps.

  7. Behçet's syndrome pathophysiology and potential therapeutic targets.

    PubMed

    Emmi, Giacomo; Silvestri, Elena; Squatrito, Danilo; D'Elios, Mario Milco; Ciucciarelli, Lucia; Prisco, Domenico; Emmi, Lorenzo

    2014-04-01

    Behçet syndrome is a systemic inflammatory disorder characterized by multiorgan involvement such as oral and genital ulcers, uveitis, skin lesions as well as by less frequent, but often more severe, central nervous system and vascular manifestations. The pathogenetic mechanisms are still incompletely known; however the interaction between a specific genetic background and environmental or infectious factors certainly contributes to the immune dysregulation that characterizes this disease. The discovery of new immunological pathways in Behçet syndrome pathogenesis may help us to set up new treatments. In this review, we will focus our attention on the possible mechanisms underlying Behçet syndrome pathogenesis and their potential role as novel therapeutic targets.

  8. Update on the therapy of Behçet disease

    PubMed Central

    Saleh, Zeinab

    2014-01-01

    Behçet disease is a chronic inflammatory systemic disorder, characterized by a relapsing and remitting course. It manifests with oral and genital ulcerations, skin lesions, uveitis, and vascular, central nervous system and gastrointestinal involvement. The main histopathological finding is a widespread vasculitis of the arteries and veins of any size. The cause of this disease is presumed to be multifactorial involving infectious triggers, genetic predisposition, and dysregulation of the immune system. As the clinical expression of Behçet disease is heterogeneous, pharmacological therapy is variable and depends largely on the severity of the disease and organ involvement. Treatment of Behçet disease continues to be based largely on anecdotal case reports, case series, and a few randomized clinical trials. PMID:24790727

  9. Behçet's syndrome: facts and controversies.

    PubMed

    Mat, Cem; Yurdakul, Sebahattin; Sevim, Ayşegül; Özyazgan, Yılmaz; Tüzün, Yalçın

    2013-01-01

    Behçet's syndrome is a systemic vasculitis of small and large vessels affecting both veins and arteries. Almost all patients with Behçet's syndrome have recurrent oral aphthae, followed by genital ulcers, variable skin lesions, such as erythema nodosum and papulopustuler lesions, arthritis, uveitis, thrombophlebitis, and gastrointestinal and central nervous system involvement. Recent epidemiologic works suggest that genetic factors are more important than environmental factors in its pathogenesis. European League Against Rheumatism guidelines were recently published for the treatment of Behçet's syndrome. Although these are quite useful for the management of mucocutaneous, eye, and joint involvement, treatment of vascular, neurological, and gastrointestinal involvement are still problematic as there are no controlled studies for these manifestations. This contribution addresses the epidemiology, mucocutaneous manifestations, diagnostic criteria, and evidence-based therapies, including biologic agents. Copyright © 2013 Elsevier Inc. All rights reserved.

  10. Synthesis of nano anatase for titanosilicate ETS-10 synthesis

    NASA Astrophysics Data System (ADS)

    Shafeque, Shihara

    Functionalized textiles present a vast and growing niche in the global textile market at US $400 billion [1, 2]. Engelhard Titanium Silicate 10 (ETS-10), a photocatalytic zeo-type material if coated on textiles, is expected to impart useful properties similar to TiO2, such as stain-resistant, odor repellant, bactericidal and enhanced UV protection [3, 4]. Typically, small ETS-10 crystals of size ˜300-800 nm are synthesized using solid titania (e.g., anatase or P25) sources [5, 6, 7]. However, smaller ETS-10 crystals are required for a uniform surface coating with highly effective surface area. The dissolution of titania particles (i.e., their size) is hypothesized to be important in small ETS-10 crystal formation [5, 6, 7]. Nano anatase was synthesized by modification of two methods: direct precipitation [7] and sol-gel synthesis [3]. Analysis by XRD confirmed that both methods produced nano anatase of crystallite size ˜4-5 nm. However, FE-SEM analysis showed that product from direct precipitation, existed as intergrown spheroidal particles with size ˜1.0 mum. These particles dispersed poorly in deionized water. Therefore, the best nano anatase samples were from sol-gel synthesis in two forms, dry powder and colloidal anatase. ETS-10 synthesis was investigated using two methods adopted from literature [6, 7]. The method of Yoon and co-workers [7], with nano anatase in a molar composition of 5.5TEOS: TiO2: 8.4NaOH: 1.43KF: 350H2O: 2.2H2SO4 produced unknown phase(s) with some ETS-10 and quartz. Using colloidal anatase with molar composition 5.5TEOS:1.0TiO 2:8.4NaOH:1.43KF:400H2O:2.2H2SO4 also produced unknown phase(s). The method of Anderson and co-workers [6] with nano anatase powder in a molar composition of 5.5SiO2: TiO 2: 5.2Na2O: 0.5K2O: 113H2O produced quartz with ETS-10 impurity. When colloidal anatase was used, with molar composition TiO2:5.5SiO2:5.2Na2O:0.5K2O:332H 2O, unreacted anatase and quartz were formed. It was hypothesized that the very low

  11. Slow release of NO by microporous titanosilicate ETS-4.

    PubMed

    Pinto, Moisés L; Rocha, João; Gomes, José R B; Pires, João

    2011-04-27

    A novel approach to designing nitric oxide (NO) storage and releasing microporous agents based on very stable, zeolite-type silicates possessing framework unsaturated transition-metal centers has been proposed. This idea has been illustrated with ETS-4 [Na(9)Si(12)Ti(5)O(38)(OH)·xH(2)O], a titanosilicate that displays excellent NO adsorption capacity and a slow releasing kinetics. The performance of these materials has been compared to the performance of titanosilicate ETS-10, [(Na,K)(2)Si(5)TiO(13)·xH(2)O], of benchmark zeolites mordenite and CaA, and of natural and pillared clays. DFT periodic calculations have shown that the presence of water in the pores of ETS-4 promotes the NO adsorption at the unsaturated (pentacoordinated) Ti(4+) framework ions.

  12. Transport de Particules et Atmospheres D'etoiles Magnetiques

    NASA Astrophysics Data System (ADS)

    LeBlanc, Francis

    1995-01-01

    Les phenomenes relies a la diffusion atomique dans les etoiles sont etudies de facon intensive depuis environ un quart de siecle. La diffusion peut a la fois modifier les abondances atomiques presentes ainsi qu'affecter la structure et l'evolution stellaires. Dans cette these, nous allons etudier trois phenomenes physiques relies a la diffusion. Nous avons developpe la theorie de la derive induite par la radiation afin qu'elle soit facilement applicable dans le contexte de l'astrophysique stellaire. Des calcuis detailles furent effectues afin d'evaluer l'importance de cet effet sur la diffusion relative de l'^3 He et l'^4He et montrent que la derive induite par la radiation accelere la separation de ces deux isotopes dans une etoile de temperature effective de 18000 K. Lorsque l'^4He est present, ce phenomene augmente la vitesse de derive de l'^3He qui migre vers l'exterieur ce qui fait apparai tre la surabondance de cet isotope plus tot dans l'evolution. Des calculs sur le lithium a la base de la zone convective d'une etoile avec une temperature effective de 6700 K monuent que la derive induite par la radiation n'est pas importante dans ce cas. Ce phenomene semble aussi etre negligeable pour l'oxygene dans les etoiles de type A ainsi que pour le mercure dans les etoiles de type B. Deuxiemement nous avons construit des modeles d'atmospheres d'etoiles ayant un champ magnetique horizontal et constant en incluant l'interaction entre ce champ et la diffusion ambipolaire de l'hydrogene. Cette interaction cause une compression de la zone d'ionisation de l'hydrogene. Dans un modele de temperature effective de 10,000 K, et avec log g = 4.0 la gravite effective, c'est-a-dire la gravite plus l'acceleration causee par la force de Lorentz, en presence d'un champ magnetique de 5 kG est sept fois plus grande que la gravite. Ce phenomene affecte donc fortement la structure des etoiles Ap. Cette modification de la structure des etoiles magnetiques cause un plus grand elargissement

  13. Innovations en vaccinologie: enjeux et perspectives pour l’Afrique

    PubMed Central

    Diop, Doudou; Sanicas, Melvin

    2017-01-01

    La vaccination est incontestablement l’une des interventions de santé publique les plus efficaces et les plus rentables qui soient. Les vaccins continuent de révolutionner notre capacité à prévenir les maladies et à améliorer la santé. Avec toutes les avancées technologiques, nous sommes en mesure d’étendre les avantages des vaccins à plus de gens et de fournir une meilleure protection contre les maladies infectieuses mortelles. Toutefois, avec le développement incessant de nouvelles souches microbiennes à travers le monde, la recherche en vaccinologie se doit d’innover continuellement. D’énormes progrès ont été réalisés pour améliorer la couverture vaccinale et introduire de nouveaux vaccins en Afrique. De nouveaux types de vaccins associés à des outils de vectorisation, d’administration et de délivrance spécifiques mais aussi des adjuvants susceptibles de moduler finement la réponse immunitaire sont attendus dans le futur. En Afrique, il est nécessaire de développer une approche régionale afin de répondre efficacement aux nombreux défis. Une meilleure information, la formation des personnels de santé en vaccinologie et des recherches bien ciblées sont les clés des futurs accomplissements dans le domaine. PMID:28690749

  14. Reality versus fantasy: reply to Lynn et al. (2014).

    PubMed

    Dalenberg, Constance J; Brand, Bethany L; Loewenstein, Richard J; Gleaves, David H; Dorahy, Martin J; Cardeña, Etzel; Frewen, Paul A; Carlson, Eve B; Spiegel, David

    2014-05-01

    We respond to Lynn et al.'s (2014) comments on our review (Dalenberg et al., 2012) demonstrating the superiority of the trauma model (TM) over the fantasy model (FM) in explaining the trauma-dissociation relationship. Lynn et al. conceded that our meta-analytic results support the TM hypothesis that trauma exposure is a causal risk factor for the development of dissociation. Although Lynn et al. suggested that our meta-analyses were selective, we respond that each omitted study failed to meet inclusion criteria; our meta-analyses thus reflect a balanced view of the predominant trauma-dissociation findings. In contrast, Lynn et al. were hypercritical of studies that supported the TM while ignoring methodological problems in studies presented as supportive of the FM. We clarify Lynn et al.'s misunderstandings of the TM and demonstrate consistent superiority in prediction of time course of dissociative symptoms, response to psychotherapy of dissociative patients, and pattern of relationships of trauma to dissociation. We defend our decision not to include studies using the Dissociative Experiences Scale-Comparison, a rarely used revision of the Dissociative Experiences Scale that shares less than 10% of the variance with the original scale. We highlight several areas of agreement: (a) Trauma plays a complex role in dissociation, involving indirect and direct paths; (b) dissociation-suggestibility relationships are small; and (c) controls and measurement issues should be addressed in future suggestibility and dissociation research. Considering the lack of evidence that dissociative individuals simply fantasize trauma, future researchers should examine more complex models of trauma and valid measures of dissociation.

  15. Palladium nanoparticles formed on titanium silicate ETS-10.

    PubMed

    Lin, Christopher C H; Danaie, Mohsen; Mitlin, David; Kuznicki, Steven M

    2011-03-01

    We report that surface templated and supported palladium nanoparticles self assemble on ETS-10 type molecular sieve surfaces by simple exchange and activation procedures in the absence of a reductant. This procedure is similar to the one previously reported for silver nanoparticle self assembly on ETS-10. We observed a bimodal distribution with particle sizes ranging from 2-5 and 15-30 nm. This simple, economical method generates high concentrations (approximately 12 wt% of total composite) of uniform, metallic palladium nanoparticles that are multiply twinned and thermally stable making them potentially unique for advanced catalytic and electronic applications.

  16. PhET: Interactive Simulations for Teaching and Learning Physics

    NASA Astrophysics Data System (ADS)

    Perkins, Katherine; Adams, Wendy; Dubson, Michael; Finkelstein, Noah; Reid, Sam; Wieman, Carl; LeMaster, Ron

    2006-01-01

    The Physics Education Technology (PhET) project creates useful simulations for teaching and learning physics and makes them freely available from the PhET website (http://phet.colorado.edu). The simulations (sims) are animated, interactive, and game-like environments in which students learn through exploration. In these sims, we emphasize the connections between real-life phenomena and the underlying science, and seek to make the visual and conceptual models of expert physicists accessible to students. We use a research-based approach in our design—incorporating findings from prior research and our own testing to create sims that support student engagement with and understanding of physics concepts.

  17. Right Ventricular Thrombus with Behçet's Syndrome

    PubMed Central

    Dogan, Sait M.; Birdane, Alparslan; Korkmaz, Cengiz; Ata, Necmi; Timuralp, Bilgin

    2007-01-01

    Behçet's syndrome is a chronic multisystem disease that presents with recurrent oral and genital ulceration and recurrent uveitis. Cardiac involvement is an extremely rare manifestation of this disorder. A 33-year-old man with Behçet's syndrome was admitted to our department with a history of cough, fever, chest pain, hemoptysis, and weight loss. Transthoracic and transesophageal echocardiography revealed a right ventricular thrombus. After 1 month of treatment with warfarin, cyclophosphamide, and corticosteroid, the intracardiac thrombus resolved. PMID:17948088

  18. Macrosomie fœtale à Lubumbashi: facteurs de risque et pronostic maternel et périnatal

    PubMed Central

    Luhete, Prosper Kakudji; Mukuku, Olivier; Kiopin, Patrick Mubinda; Tambwe, Albert Mwembo; Kayamba, Prosper Kalenga Muenze

    2016-01-01

    Introduction La macrosomie fœtale est habituellement définie par un poids de naissance supérieur ou égal à 4000 grammes. L'objectif de cette étude est de déterminer la fréquence de la macrosomie, d'identifier les facteurs étiologiques et d’évaluer le pronostic maternel et périnatal. Méthodes Il s'agit d'une étude cas-témoins menéeau sein des maternités de 10 hôpitaux généraux de référence de la ville de Lubumbashi en République Démocratique du Congoentre le 1er décembre 2013 et le 31 mars 2014. Les accouchées ont été réparties en deux groupes, en fonction du poids de naissance de leurs nouveau-nés: groupe I (≥4000 grammes ou plus) et groupe II (2500 à 3500 grammes). Les caractéristiques maternelles, l'environnement obstétrical ainsi que le pronostic maternel et périnatal ont été étudiés et comparés dans les deux groupes. Les données ont été analysées à l'aide du logiciel Épi info version 7.1. Les différences étaient jugées significatives pour un seuil de p<0,05. Résultats Au total, 668 mères et leurs nouveau-nés ont été inclus dont 167 macrosomes et 501témoins. L'incidence de la macrosomie fœtale était de 5,7%. Comparativement aux mères de témoins, nous avons trouvé que les mères des nouveau-nés macrosomes étaient plus âgées, multipares, multigestes, obèses, diabétiques et avaient antérieurement donné naissance à un macrosome. Les taux de césarienne et de délivrance pathologique étaient significativement élevés chez les mères de macrosomes que chez celles de témoins. Lesexe masculin était significativement plus prédominant chez macrosomes que chez les témoins. La dystocie des épaules étaitenregistrée uniquement dans le groupe des macrosomes. Conclusion La prévalence de l'accouchement d'un macrosome à Lubumbashi est de 5,7%. La macrosomie est souvent à l'origine de complications maternelles et périnatales. La réduction de ces dernières passe par une meilleure connaissance des

  19. Relationships between water table and model simulated ET

    Prem B. Parajuli; Gretchen F. Sassenrath; Ying Ouyang

    2013-01-01

    This research was conducted to develop relationships among evapotranspiration (ET), percolation (PERC), groundwater discharge to the stream (GWQ), and water table fluctuations through a modeling approach. The Soil and Water Assessment Tool (SWAT) hydrologic and crop models were applied in the Big Sunflower River watershed (BSRW; 7660 km2) within the Yazoo River Basin...

  20. Behçet's syndrome in Iranian Azari people.

    PubMed

    Shahneh, Fatemeh Zare; Babaloo, Zohreh; Baradaran, Behzad; Hamzavi, Fatemeh; Bayazi, Babak; Bandehagh, Ali

    2012-11-01

    Behçet's Syndrome (BS) is a chronic recurrent multisystemic inflammatory disorder characterized by oral and genital ulcers, ocular inflammation. Behçet's syndrome has a complex genetic etiology. However, epidemiological studies recommend that genetic factors have a significant influence to its pathogenesis, alike to other autoinflammatory disorders. Epidemiological statistics, clinical records and HLA typing were studied in Iranian Azari patients with Behçet's syndrome. This investigation considered HLA associations with BS and HLA with certain clinical characteristics, age and sex in the (Tabriz) Iran which has an ethnically homogeneous population. HLA-A and HLA-B typing was performed in 290 BS patients, conforming to International Study Group criteria and in 300 blood donors, as controls. Patient records were retrospectively reviewed and patients reassessed clinically. HLA-B5, HLA-B35, HLA-51, HLA-B52 and HLA-CW4 presented significantly high frequencies in all patients. No other HLA type was associated. There was a significant HLA link with male sex in BS patients and Mean age (34 +/- 1.1) was determined. We present the frequency and correlation between Iranian Azari patients with Behçet's syndrome and particular HLA antigens. Ninety nine percent had mouth ulceration, 64% genital ulceration, 72% skin lesions and 52% ocular involvement. This study supports HLA-B5, HLA-B35, HLA-51, HLA-B52 and HLA-CW4 immunogenetic predisposition in an ethnically homogeneous (Iranian Azari) population.

  1. Photocopy of drawing. VAB HB2 & 4 ET HOLDING CELLS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing. VAB HB-2 & 4 ET HOLDING CELLS, UPGRADE TO CHECKOUT CELLS. NASA John F. Kennedy Space Center, Florida. File Number 79K33180, Reynolds, Smith & Hill, February 1991. GENERAL ARRANGEMENT, PLAN & ELEVATIONS. Sheet 4 - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

  2. Photocopy of drawing. VAB HB2 & 4 ET HOLDING CELLS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing. VAB HB-2 & 4 ET HOLDING CELLS, UPGRADE TO CHECKOUT CELLS. NASA John F. Kennedy Space Center, Florida. File Number 79K33180, Reynolds, Smith & Hill, February 1991. HINGED PANEL EQUIPMENT SCHEDULE. Sheet 28 - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

  3. 78 FR 40213 - Charles Schwab Investment Management, Inc., et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... Schwab Investment Management, Inc., et al.; Notice of Application June 27, 2013. AGENCY: Securities and... exemption from sections 12(d)(1)(A) and (B) of the Act. Applicants: Charles Schwab Investment Management...) certain registered management investment companies and unit investment trusts outside of the same group of...

  4. 76 FR 23342 - Russell Investment Management Company, et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ...] Russell Investment Management Company, et al.; Notice of Application April 20, 2011. AGENCY: Securities...: Applicants request an order that would permit (a) series of certain open-end management investment companies... registered management investment companies and unit investment trusts outside of the same group of investment...

  5. 76 FR 72729 - SEI Investments Management Corporation, et al.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-25

    ...] SEI Investments Management Corporation, et al. November 18, 2011. AGENCY: Securities and Exchange... Application: Applicants request an order to permit open-end management investment companies relying on rule 12d1-2 under the Act to invest in certain financial instruments. Applicants: SEI Investments Management...

  6. Episodic Tremor and Slip (ETS) as a chaotic multiphysics spring

    NASA Astrophysics Data System (ADS)

    Veveakis, E.; Alevizos, S.; Poulet, T.

    2017-03-01

    Episodic Tremor and Slip (ETS) events display a rich behaviour of slow and accelerated slip with simple oscillatory to complicated chaotic time series. It is commonly believed that the fast events appearing as non volcanic tremors are signatures of deep fluid injection. The fluid source is suggested to be related to the breakdown of hydrous phyllosilicates, mainly the serpentinite group minerals such as antigorite or lizardite that are widespread in the top of the slab in subduction environments. Similar ETS sequences are recorded in different lithologies in exhumed crustal carbonate-rich thrusts where the fluid source is suggested to be the more vigorous carbonate decomposition reaction. If indeed both types of events can be understood and modelled by the same generic fluid release reaction AB(solid) ⇌A(solid) +B(fluid) , the data from ETS sequences in subduction zones reveal a geophysically tractable temporal evolution with no access to the fault zone. This work reviews recent advances in modelling ETS events considering the multiphysics instabilities triggered by the fluid release reaction and develops a thermal-hydraulic-mechanical-chemical oscillator (THMC spring) model for such mineral reactions (like dehydration and decomposition) in Megathrusts. We describe advanced computational methods for THMC instabilities and discuss spectral element and finite element solutions. We apply the presented numerical methods to field examples of this important mechanism and reproduce the temporal signature of the Cascadia and Hikurangi trench with a serpentinite oscillator.

  7. FIELD EVALUATION OF EVAPO-TRANSPIRATION (ET) CAPS

    EPA Science Inventory

    A field study was conducted to assess the ability of landfill covers to control percolation into the waste. Performance of one conventional cover was compared to that of two evapotranspiration (ET) tree covers, using large (7 x 14 m) lined lysimeters at the Leon County Solid W...

  8. 75 FR 67950 - National Institutes of Health, et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ... DEPARTMENT OF COMMERCE International Trade Administration National Institutes of Health, et al.; Notice of Consolidated Decision on Applications for Duty-Free Entry of Electron Microscopes This is a... Constitution Avenue, NW., Washington, DC. Docket Number: 10-055. Applicant: National Institutes of Health...

  9. 78 FR 20701 - Munder Series Trust, et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... designed to ensure that the Sub-Advisers comply with a Sub- Advised Series' investment objectives, policies...] Munder Series Trust, et al.; Notice of Application March 29, 2013. AGENCY: Securities and Exchange... would grant relief from certain disclosure requirements. [[Page 20702

  10. 76 FR 19150 - Jackson National Life Insurance Company, et al.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... Life Insurance Company, et al. March 31, 2011. AGENCY: The Securities and Exchange Commission...: Jackson National Life Insurance Company (``Jackson''), Jackson National Separate Account--I (the ``JNL Separate Account''), Jackson National Life Insurance Company of New York (``JNLNY'') and collectively with...

  11. 78 FR 38413 - American Family Life Insurance Company, et al.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ...] American Family Life Insurance Company, et al. June 20, 2013. AGENCY: Securities and Exchange Commission...: American Family Life Insurance Company (the ``Company''), American Family Variable Account I (the ``Life... Products Fund (``Fidelity Fund''), currently held by the Life Account and the Annuity Account (each an...

  12. 78 FR 54691 - American General Life Insurance Company, et al.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... Life Insurance Company, et al. August 29, 2013, AGENCY: The Securities and Exchange Commission... 27(i)(2)(A) of the Act and Rule 22c-1 thereunder. Applicants: American General Life Insurance Company (``American General''), The United States Life Insurance Company in the City of New York (``US Life'') (each...

  13. 75 FR 18908 - Jackson National Life Insurance Company, et al.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... Life Insurance Company, et al. April 7, 2010. AGENCY: The Securities and Exchange Commission... purchase payments made under certain deferred variable annuity contracts. APPLICANTS: Jackson National Life...''), Jackson National Life Insurance Company of New York (``JNL New York'' and collectively with Jackson...

  14. 75 FR 66806 - Nationwide Life Insurance Company, et al.,

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ...] Nationwide Life Insurance Company, et al., Notice of Application October 25, 2010. AGENCY: Securities and... exemption pursuant to Section 17(b) of the Act from Section 17(a) of the Act. Applicants: Nationwide Life Insurance Company (``NWL''), Nationwide Life and Annuity Insurance Company (``NLAIC'') (together with NWL...

  15. 75 FR 60833 - Jackson National Life Insurance Company, et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ...] Jackson National Life Insurance Company, et al.; Notice of Application September 27, 2010. AGENCY... National Life Insurance Company (``Jackson''), Jackson National Life Insurance Company of New York... Companies and serve as the underlying investment vehicles for the variable life insurance contracts and...

  16. Plan of advanced satellite communication experiments using ETS-6

    NASA Technical Reports Server (NTRS)

    Ikegami, Tetsushi

    1989-01-01

    In 1992, an Engineering Test Satellite 6 is scheduled to be launched by an H-2 rocket. The missions of ETS-6 are to establish basic technologies of inter-satellite communications using S-band, millimeter waves and optical beams and of fixed and mobile satellite communications using multibeam antenna on board the satellite. A plan of the experiments is introduced.

  17. 77 FR 64568 - Medley Capital Corporation, et al.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... Capital Corporation, et al.; Notice of Application October 16, 2012. AGENCY: Securities and Exchange.... Applicants: Medley Capital Corporation (the ``Company''), MCC Advisors LLC (the ``Investment Adviser.... Applicants' Representations 1. The Company, a Delaware corporation, is an externally managed, non-diversified...

  18. 76 FR 62470 - MFS Series Trust I, et al.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ...] MFS Series Trust I, et al.; Notice of Application September 30, 2011. AGENCY: Securities and Exchange... Series Trust I, MFS Series Trust II, MFS Series Trust III, MFS Series Trust IV, MFS Series Trust V, MFS Series Trust VI, MFS Series Trust VII, MFS Series Trust VIII, MFS Series Trust IX, MFS Series Trust X...

  19. New EU ETS Phase 4 rules temporarily puncture waterbed

    NASA Astrophysics Data System (ADS)

    Perino, Grischa

    2018-04-01

    The new rules of the EU ETS will fundamentally change its character. The long-term cap on emissions will become a function of past and future market outcomes, temporarily puncturing the waterbed and having retroactive impacts on GHG abatement from overlapping policies.

  20. "The Et Tu Brute Complex" Compulsive Self Betrayal

    ERIC Educational Resources Information Center

    Antus, Robert Lawrence

    2006-01-01

    In this article, the author discusses "The Et Tu Brute Complex." More specifically, this phenomenon occurs when a person, instead of supporting and befriending himself, orally condemns himself in front of other people and becomes his own worst enemy. This is a form of compulsive self-hatred. Most often, the victim of this complex is unaware of the…

  1. 76 FR 77775 - University of Florida, et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ... DEPARTMENT OF COMMERCE International Trade Administration University of Florida, et al.; Notice of... Constitution Avenue NW., Washington, DC. Docket Number: 11-065. Applicant: University of Florida, Gainesville...: See notice at 76 FR 70410, November 14, 2011. Docket Number: 11-066. Applicant: University of Florida...

  2. 75 FR 67950 - The University of Georgia (UGA), et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ... DEPARTMENT OF COMMERCE International Trade Administration The University of Georgia (UGA), et al.; Notice of Decision on Applications for Duty-Free Entry of Scientific Instruments This is a decision...., NW., Washington, DC. Docket Number: 10-054. Applicant: The University of Georgia (UGA), Athens, GA...

  3. Communication et pragmatique interculturelles (Intercultural Communication and Pragmatics).

    ERIC Educational Resources Information Center

    Singy, Pascal, Ed.; Trudgill, Peter, Ed.

    1997-01-01

    This collection of articles on intercultural communication and pragmatics includes: "Peut-on traduire la publicite? L'exemple des annonces romandes et alemaniques" ("Does Advertising Translate? The Example of Romansch and German Ads") (Marc Bonhomme, Michael Rinn); "La construction de l'image de l'autre dans l'interaction.…

  4. An Exemplary High School Literary Magazine: "Et Cetera."

    ERIC Educational Resources Information Center

    Holbrook, Hilary Taylor, Comp.

    One of a series of 20 literary magazine profiles written to help faculty advisors wishing to start or improve their publication, this profile provides information on staffing and production of "Et Cetera," the magazine published by Clarkstown High School, New City, New York. The introduction describes the literary magazine contest (and…

  5. 77 FR 48566 - The Hartford Mutual Funds, Inc., et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ...] The Hartford Mutual Funds, Inc., et al.; Notice of Application August 8, 2012. AGENCY: Securities and... to invest in certain financial instruments. Applicants: The Hartford Mutual Funds, Inc., The Hartford Mutual Funds II, Inc., Hartford Series Fund, Inc., Hartford HLS Series Fund II, Inc., Hartford Variable...

  6. Citation Analysis of "Geochimica et Cosmochimica Acta," 1951-1960.

    ERIC Educational Resources Information Center

    Lifshin, Arthur

    1993-01-01

    A citation analysis of the first 10 years of "Geochimica et Cosmochimica Acta" from 1951 to 1960 is described. A shift from German to English language citations and the emerging importance of the journal in the field, which is undergoing a change resulting from technological innovation, are shown. Tables and graphs are included. (EAM)

  7. Lésions concomitantes aux genoux flottants et gravite

    PubMed Central

    Eone, Daniel Handy; Lamah, Léopold; Bayiha, Jean Emile; Ondoa, Danielle Larissa Essomba; Nonga, Bernadette Ngo; Ibrahima, Farikou; Bahebeck, Jean

    2016-01-01

    Le genou flottant est issu d’un traumatisme de haute énergie, dont la genèse suggère de vaste dégâts aussi bien sur le plan locorégional que général. Faisant référence au polytaumatisme. Le but de notre étude était de recenser toutes les lésions concomitantes au genou flottant dans notre milieu de pratique et d’évaluer la sévérité. Nous avons mené une étude descriptive et rétrospective couvrant une période de 14 ans et 9 mois. Sur un échantillon de 75 genoux flottants, avec une moyenne d’âge de 35 ans. Soixante six patients avaient obtenu un score d’ISS supérieur ou égal à 16 donc qualifié de polytraumatisé. Les traumatismes crâniens, les lésions thoraciques et abdominales retrouvés en même temps que le genou flottant exigent une réanimation adéquate. PMID:28292046

  8. ETS Research on Cognitive, Personality, and Social Psychology: I. Research Report. ETS RR-13-01. ETS R&D Scientific and Policy Contributions Series. ETS SPC-13-01

    ERIC Educational Resources Information Center

    Stricker, Lawrence J.

    2013-01-01

    This is an account of a portion of the research on cognitive, personality, and social psychology at ETS since the organization's inception. The topics in cognitive psychology are the structure of abilities; in personality psychology, response styles and social and emotional intelligence; and in social psychology, prosocial behavior and stereotype…

  9. 77 FR 15145 - Ares Capital Corporation et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-14

    ...] Ares Capital Corporation et al.; Notice of Application March 9, 2012. AGENCY: Securities and Exchange... Company Act of 1940 (the ``Act'') for an exemption from section 12(d)(3) of the Act. Applicants: Ares Capital Corporation (the ``Company''), Ares Capital Management LLC (``ACM'') and Ivy Hill Asset Management...

  10. 76 FR 62475 - Global X Funds, et al.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ...] Global X Funds, et al.; Notice of Application September 30, 2011. AGENCY: Securities and Exchange....\\1\\ \\1\\ Global X Funds and Global X Management Company LLC, Investment Company Act Release Nos. 28378 (Sep. 10, 2008) (notice) and 28433 (Oct. 3, 2008) (order). Applicants: Global X Funds (the ``Trust...

  11. 76 FR 41831 - FQF Trust, et al.; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ...] FQF Trust, et al.; Notice of Application July 11, 2011. AGENCY: Securities and Exchange Commission... Creation Units; and (e) certain registered management investment companies and unit investment trusts outside of the same group of investment companies as the series to acquire Shares. Applicants: FQF Trust...

  12. 76 FR 58849 - Legg Mason Partners Equity Trust, et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ...] Legg Mason Partners Equity Trust, et al.; Notice of Application September 15, 2011. AGENCY: Securities... Trust (``LMP Equity Trust''), Legg Mason Partners Variable Equity Trust (``LMP Variable Equity Trust'' and together with LMP Equity Trust, the ``Trusts''), Legg Mason Partners Fund Advisor, LLC (``LMPFA...

  13. 78 FR 59985 - Variable Insurance Trust, et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ... Trust, et al.; Notice of Application September 24, 2013. AGENCY: Securities and Exchange Commission... Trust (the ``Fund'') and MFund Services LLC (``MFund'') (collectively, ``Applicants''). SUMMARY: Summary... Services LLC, 22 High Street, Huntington, NY 11743 and Jerry Szilagyi, Variable Insurance Trust, 5...

  14. 77 FR 16871 - Forward Funds, et al.; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 29982; File No. 812-13996] Forward Funds, et al.; Notice of Application March 15, 2012. AGENCY: Securities and Exchange Commission (``Commission''). ACTION: Notice of an application under section 6(c) of the Investment Company Act of 1940...

  15. Exploring Essential Conditions: A Commentary on Bull et al. (2008)

    ERIC Educational Resources Information Center

    Borthwick, Arlene; Hansen, Randall; Gray, Lucy; Ziemann, Irina

    2008-01-01

    The editorial by Bull et al. (2008) on connections between informal and formal learning made explicit one element of solving what Koehler and Mishra (2008) termed a "wicked problem." This wicked (complex, ill-structured) problem involves working with teachers for effective integration of technology in support of student learning. The…

  16. Evolving Science in Adolescence: Comment on Ellis et al. (2012)

    ERIC Educational Resources Information Center

    Dodge, Kenneth A.; Albert, Dustin

    2012-01-01

    Ellis et al. (2012) bring an evolutionary perspective to bear on adolescent risky behavioral development, clinical practice, and public policy. The authors offer important insights that (a) some risky behaviors may be adaptive for the individual and the species by being hard-wired due to fitness benefits and (b) interventions might be more…

  17. Assessing the Incremental Algorithm: A Response to Krahmer et al.

    ERIC Educational Resources Information Center

    van Deemter, Kees; Gatt, Albert; van der Sluis, Ielka; Power, Richard

    2012-01-01

    This response discusses the experiment reported in Krahmer et al.'s Letter to the Editor of "Cognitive Science". We observe that their results do not tell us whether the Incremental Algorithm is better or worse than its competitors, and we speculate about implications for reference in complex domains, and for learning from "normal" (i.e.,…

  18. Reconnaissance invariante d'objets 3-D et correlation SONG

    NASA Astrophysics Data System (ADS)

    Roy, Sebastien

    Cette these propose des solutions a deux problemes de la reconnaissance automatique de formes: la reconnaissance invariante d'objets tridimensionnels a partir d'images d'intensite et la reconnaissance robuste a la presence de bruit disjoint. Un systeme utilisant le balayage angulaire des images et un classificateur par trajectoires d'espace des caracteristiques permet d'obtenir la reconnaissance invariante d'objets tridimensionnels. La reconnaissance robuste a la presence de bruit disjoint est realisee au moyen de la correlation SONG. Nous avons realise la reconnaissance invariante aux translations, rotations et changements d'echelle d'objets tridimensionnels a partir d'images d'intensite segmentees. Nous utilisons le balayage angulaire et un classificateur a trajectoires d'espace des caracteris tiques. Afin d'obtenir l'invariance aux translations, le centre de balayage angulaire coincide avec le centre geometrique de l'image. Le balayage angulaire produit un vecteur de caracteristiques invariant aux changements d'echelle de l'image et il transforme en translations du signal les rotations autour d'un axe parallele a la ligne de visee. Le classificateur par trajectoires d'espace des caracteristiques represente une rotation autour d'un axe perpendiculaire a la ligne de visee par une courbe dans l'espace. La classification se fait par la mesure de la distance du vecteur de caracteristiques de l'image a reconnaitre aux trajectoires stockees dans l'espace. Nos resultats numeriques montrent un taux de classement atteignant 98% sur une banque d'images composee de 5 vehicules militaires. La correlation non-lineaire generalisee en tranches orthogonales (SONG) traite independamment les niveaux de gris presents dans une image. Elle somme les correlations lineaires des images binaires ayant le meme niveau de gris. Cette correlation est equivalente a compter le nombre de pixels situes aux memes positions relatives et ayant les memes intensites sur deux images. Nous presentons

  19. Effets thermoelectrique et thermomagnetique du yttrium barium copper oxide monocristallin

    NASA Astrophysics Data System (ADS)

    Ghamlouche, Hassan

    1998-09-01

    Des la decouverte des supraconducteurs a haute temperature critique, les recherches se sont intensifiees afin de comprendre les mecanismes qui sont a l'origine des proprietes de ces materiaux L'etat mixte, tout comme l'etat supraconducteur pur et l'etat normal, a fait l'objet de nombreux travaux de recherche. En particulier, la structure des vortex a l'etat mixte, et leur mouvement sous l'effet d'une force quelconque, etaient et restent le centre de preoccupation. Les effets thermoelectrique (Seebeck) et thermomagnetique (Nernst) sont parmi les differentes mesures qui peuvent donner de l'information sur les etats des vortex a l'etat mixte. L'avantage essentiel de ces deux effets est l'absence d'un courant electrique applique. Ce dernier peut donner des perturbations indesirables durant les mesures. D'autre pari, nous avons utilise la methode CA (Courant Alternatif) pour effectuer nos mesures. Cette methode est caracterisee par une meilleure resolution par rapport a la methode CC (Courant Continu) conventionnelle. Nous avons etudie autant des echantillons macles que des echantillons sans macles. D'abord nous avons teste notre montage a champ magnetique nul. Nous avons alors montre que le pic rapporte par certains dans l'effet Seebeck a la transition supraconductrice ne correspond pas a une realite physique mais a un artefact experimental. On avait associe ce pic aux fluctuations. Par la suite, nous avons mis en evidence et etudie pour la premiere fois avec les effets Seebeck et Nernst le phenomene de la fusion du reseau de vortex grace a des mesures sur les echantillons sans macles. Cette etude s'est faite pour deux concentrations d'oxygene differentes et pour un gradient de temperature parallele, consecutivement, aux deux axes cristallographiques dans le plan ab. Finalement, nous avons etudie l'effet des plans de maclage sur le mouvement des vortex. Ceci a ete realise en appliquant le gradient de temperature selon trois directions differentes (0, 45 et 90°) avec

  20. Estimating missing hourly climatic data using artificial neural network for energy balance based ET mapping applications

    Remote sensing based evapotranspiration (ET) mapping has become an important tool for water resources management at a regional scale. Accurate hourly climatic data and reference ET are crucial input for successfully implementing remote sensing based ET models such as Mapping ET with internal calibra...

  1. Improving Test Score Reporting: Perspectives from the ETS Score Reporting Conference. Research Report. ETS RR-11-45

    ERIC Educational Resources Information Center

    Zapata-Rivera, Diego, Ed.; Zwick, Rebecca, Ed.

    2011-01-01

    This volume includes 3 papers based on presentations at a workshop on communicating assessment information to particular audiences, held at Educational Testing Service (ETS) on November 4th, 2010, to explore some issues that influence score reports and new advances that contribute to the effectiveness of these reports. Jessica Hullman, Rebecca…

  2. ETS and tidal stressing: Fault weakening after main slip pulse

    NASA Astrophysics Data System (ADS)

    Houston, H.

    2013-12-01

    Time-varying stresses from solid Earth tides and ocean loading influence slow slip (Hawthorne and Rubin, 2010) and, consequently, the frequency of occurrence and intensity of tremor during ETS episodes (Rubinstein et al., 2008). This relationship can illuminate changes in the mechanical response of the rupture surfaces(s) during slip in ETS. I compare the influence of tidal loading when and after the propagating ETS slip front (estimated by tremor density in time) ruptures the fault at a given spot. Using estimates of slip fronts that I derived from tremor locations, I divide ETS tremor into two groups: that occurring within a day of the start of the inferred slip front and that occurring over several days thereafter. The tremor catalog used contains 50K waveform cross-correlation locations of tremor in 7 large ETS in northern Cascadia between 2005 and 2012. I calculate normal, shear and volumetric stresses due to the Earth and ocean tides at numerous locations on the inferred rupture plane of the ETS following the method of Hawthorne and Rubin (2010). The Coulomb stress increment at each tremor time and location is compared with tremor occurrence for the two groups of tremor. Unreasonable results appear if the effective frictional coefficient mu > 0.2, and results are most 'reasonable' when mu is very near or equal to zero. Following passage of the main slip pulse, tremor generation is notably more sensitive to tidal stressing. One kPa of encouraging tidal Coulomb stress boosts the occurrence of tremor after the main slip pulse by about 50% above the average value, while the same amount of discouraging stress decreases the occurrence of such tremor by a similar factor. The greater the encouraging or discouraging stress, the greater the effect. In contrast, tremor in the main slip pulse is much less affected by positive or negative tidal stresses. I interpret the greater sensitivity to tidal stressing of the tremor after the main slip pulse as a measure of the

  3. The Genyornis Egg: Response to Miller et al.'s commentary on Grellet-Tinner et al., 2016

    NASA Astrophysics Data System (ADS)

    Grellet-Tinner, Gerald; Spooner, Nigel A.; Handley, Warren D.; Worthy, Trevor H.

    2017-04-01

    Williams (1981) and Williams and Rich (1991) attributed Australian Quaternary fossil eggshell that differed from that of emu Dromaius novaehollandiae to the extinct bird Genyornis newtoni without any osteological or embryonic support. Such association by proximity or abundance mirrors the case of the mistaken association of oviraptor eggs to Protoceratops in the 1920's by Andrews (Grellet-Tinner and Makovicky, 2006). No other candidate species was considered, and this attribution has been unchallenged and followed by everyone thereafter. Much research has been done on this Australian eggshell, with one result being that the extinction of the parent of this eggshell is the most well documented for a taxon in Australia (e.g., Miller et al., 1999, 2005). Grellet-Tinner et al. (2016) raised several problems with the identity of the eggshell Williams (1981) attributed to Genyornis newtoni and suggested that extinct megapodes of the genus Progura were the more likely layer of this eggshell type, therein referred to as ;putative Genyornis oological material; (PGOM). Miller et al. (2017) challenged our hypothesis stating that ;Based on the dimensions of the reconstructed Spooner Egg,Grellet-Tinner et al. (2016)argue that PGOM is too small for a bird with the body mass estimated for Genyornis (168-275 kg) … …[and] …. None of the additional PGOM observations reported byGrellet-Tinner et al. (2016)are inconsistent with a Genyornis parent;. Here we take the opportunity to respond to their critique, the basis of which resolves into a few points, which we address in turn.

  4. Oral Conditioned Cues Can Enhance or Inhibit Ethanol (EtOH)-Seeking and EtOH-Relapse Drinking by Alcohol-Preferring (P) Rats.

    PubMed

    Knight, Christopher P; Hauser, Sheketha R; Deehan, Gerald A; Toalston, Jamie E; McBride, William J; Rodd, Zachary A

    2016-04-01

    Conditioned cues can elicit drug-seeking in both humans and rodents. The majority of preclinical research has employed excitatory conditioned cues (stimuli present throughout the availability of a reinforcer), but oral consumption of alcohol is similar to a conditional stimuli (presence of stimuli is paired with the delivery of the reinforcer) approach. The current experiments attempted to determine the effects of conditional stimuli (both excitatory and inhibitory) on the expression of context-induced ethanol (EtOH)-seeking. Alcohol-preferring (P) rats self-administered EtOH and water in standard 2-lever operant chambers. A flavor was added to the EtOH solution (CS+) during the EtOH self-administration sessions. After 10 weeks, rats underwent extinction training (7 sessions), followed by a 2-week home cage period. Another flavor was present during extinction (CS-). Rats were exposed to a third flavor in a non-drug-paired environment (CS(0)). EtOH-seeking was assessed in the presence of no cue, CS+, CS-, or CS(0) in the dipper previously associated with EtOH self-administration (no EtOH available). Rats were maintained a week in their home cage before being returned to the operant chambers with access to EtOH (flavored with no cue, CS+, CS-, or CS(0)). The results indicated that the presence of the CS+ enhanced EtOH-seeking, while the presence of the CS- suppressed EtOH-seeking. Similarly, adding the CS- flavor to 15% EtOH reduced responding for EtOH while the CS+ enhanced responding for EtOH during relapse testing. Overall, the data indicate that conditional stimuli are effective at altering both EtOH-seeking behavior and EtOH-relapse drinking. Copyright © 2016 by the Research Society on Alcoholism.

  5. Oral Conditioned Cues Can Enhance or Inhibit EtOH-Seeking and EtOH Relapse Drinking by Alcohol-Preferring (P) Rats

    PubMed Central

    Knight, Christopher P.; Hauser, Sheketha R.; Deehan, Gerald A.; Toalston, Jamie E.; McBride, William J.; Rodd, Zachary A.

    2016-01-01

    Background Conditioned cues can elicit drug-seeking in both humans and rodents. The majority of preclinical research has employed excitatory conditioned cues (stimuli present throughout the availability of a reinforcer), but oral consumption of alcohol is similar to a conditional stimuli (presence of stimuli is paired with the delivery of the reinforcer) approach. The current experiments attempted to determine the effects of conditional stimuli (both excitatory and inhibitory) on the expression of context-induced ethanol (EtOH)-seeking. Methods Alcohol-preferring (P) rats self-administered EtOH and water in standard 2-lever operant chambers. A flavor was added to the EtOH solution (CS+) during the EtOH self-administration sessions. After 10 weeks, rats underwent extinction training (7 sessions), followed by a 2-week home cage period. Another flavor was present during extinction (CS-). Rats were exposed to a third flavor in a non-drug paired environment (CS0). EtOH-seeking was assessed in the presence of no cue, CS+, CS- or CS0 in the dipper previously associated with EtOH self-administration (no EtOH available). Rats were maintained a week in their home cage before being returned to the operant chambers with access to EtOH (flavored with no Cue, CS+, CS- or CS0). Results The results indicated that the presence of the CS+ enhanced EtOH-seeking, while the presence of the CS- suppressed EtOH-seeking. Similarly, adding the CS- flavor to 15% EtOH reduced responding for EtOH while the CS+ enhanced responding for EtOH during relapse testing. Conclusions Overall, the data indicate that conditional stimuli are effective at altering both EtOH-seeking behavior and EtOH relapse drinking. PMID:27038599

  6. Estimating basin scale evapotranspiration (ET) by water balance and remote sensing methods

    Senay, G.B.; Leake, S.; Nagler, P.L.; Artan, G.; Dickinson, J.; Cordova, J.T.; Glenn, E.P.

    2011-01-01

    Evapotranspiration (ET) is an important hydrological process that can be studied and estimated at multiple spatial scales ranging from a leaf to a river basin. We present a review of methods in estimating basin scale ET and its applications in understanding basin water balance dynamics. The review focuses on two aspects of ET: (i) how the basin scale water balance approach is used to estimate ET; and (ii) how ‘direct’ measurement and modelling approaches are used to estimate basin scale ET. Obviously, the basin water balance-based ET requires the availability of good precipitation and discharge data to calculate ET as a residual on longer time scales (annual) where net storage changes are assumed to be negligible. ET estimated from such a basin water balance principle is generally used for validating the performance of ET models. On the other hand, many of the direct estimation methods involve the use of remotely sensed data to estimate spatially explicit ET and use basin-wide averaging to estimate basin scale ET. The direct methods can be grouped into soil moisture balance modelling, satellite-based vegetation index methods, and methods based on satellite land surface temperature measurements that convert potential ET into actual ET using a proportionality relationship. The review also includes the use of complementary ET estimation principles for large area applications. The review identifies the need to compare and evaluate the different ET approaches using standard data sets in basins covering different hydro-climatic regions of the world.

  7. Formulation, caracterisation, modelisation et prevision du comportement thermomecanique des pieces plastiques et composites de fibres de bois : Application aux engrenages =

    NASA Astrophysics Data System (ADS)

    Mijiyawa, Faycal

    Cette etude permet d'adapter des materiaux composites thermoplastiques a fibres de bois aux engrenages, de fabriquer de nouvelles generations d'engrenages et de predire le comportement thermique de ces engrenages. Apres une large revue de la litterature sur les materiaux thermoplastiques (polyethylene et polypropylene) renforces par les fibres de bois (bouleau et tremble), sur la formulation et l'etude du comportement thermomecanique des engrenages en plastique-composite; une relation a ete etablie avec notre presente these de doctorat. En effet, beaucoup d'etudes sur la formulation et la caracterisation des materiaux composites a fibres de bois ont ete deja realisees, mais aucune ne s'est interessee a la fabrication des engrenages. Les differentes techniques de formulation tirees de la litterature ont facilite l'obtention d'un materiau composite ayant presque les memes proprietes que les materiaux plastiques (nylon, acetal...) utilises dans la conception des engrenages. La formulation des materiaux thermoplastiques renforces par les fibres de bois a ete effectuee au Centre de recherche en materiaux lignocellulosiques (CRML) de l'Universite du Quebec a Trois-Rivieres (UQTR), en collaboration avec le departement de Genie Mecanique, en melangeant les composites avec deux rouleaux sur une machine de type Thermotron-C.W. Brabender (modele T-303, Allemand) ; puis des pieces ont ete fabriquees par thermocompression. Les thermoplastiques utilises dans le cadre de cette these sont le polypropylene (PP) et le polyethylene haute densite (HDPE), avec comme renfort des fibres de bouleau et de tremble. A cause de l'incompatibilite entre la fibre de bois et le thermoplastique, un traitement chimique a l'aide d'un agent de couplage a ete realise pour augmenter les proprietes mecaniques des materiaux composites. Pour les composites polypropylene/bois : (1) Les modules elastiques et les contraintes a la rupture en traction des composites PP/bouleau et PP/tremble evoluent

  8. Brief Exposures to the Taste of Ethanol (EtOH) and Quinine Promote Subsequent Acceptance of EtOH in a Paradigm that Minimizes Postingestive Consequences.

    PubMed

    Loney, Gregory C; Meyer, Paul J

    2018-03-01

    Aversion to the orosensory properties of concentrated ethanol (EtOH) solutions is often cited as a primary barrier to initiation of drinking and may contribute to abstention. These aversive properties include gustatory processes which encompass both bitter-like taste qualities and trigeminal-mediated irritation. Chronic intermittent EtOH access (CIA) results in substantial and persistent increases in EtOH consumption, but the degree to which this facilitation involves sensory responding to EtOH and other bitter stimuli is currently undetermined. Long-Evans rats were given brief-access licking tests designed to examine the immediate, taste-guided assessment of the palatability of EtOH and quinine solutions. Rats were assessed once in a naïve state and again following previous brief-access exposure, or following 4 weeks of CIA. The relationship between the sensitivity to the aversive orosensory properties of EtOH and quinine following EtOH access and the impact of antecedent quinine exposure on the acceptance of EtOH were determined in 2 parallel studies. Both brief access to EtOH and 4-week CIA resulted in substantial rightward shifts in the concentration-response function of brief-access EtOH licking, indicating that EtOH exposure increased acceptance of the taste of EtOH. The initial sensitivity to the aversive orosensory properties of EtOH and quinine was positively correlated in naïve rats, such that rats that were initially more accepting of quinine were also more accepting of EtOH. Rats that sampled quinine immediately prior to tasting EtOH exhibited successive positive contrast in that they were more accepting of highly concentrated EtOH, relative to a water-control group. Increased EtOH acceptance following exposure is, at least in part, facilitated by a decrease in its aversive sensory properties. Both long- and short-term access increase the palatability of the taste of EtOH in brief-access licking tests. Moreover, the sensitivity to the bitterness of

  9. Role of endothelin-converting enzyme, chymase and neutral endopeptidase in the processing of big ET-1, ET-1(1-21) and ET-1(1-31) in the trachea of allergic mice.

    PubMed

    De Campo, Benjamin A; Goldie, Roy G; Jeng, Arco Y; Henry, Peter J

    2002-08-01

    The present study examined the roles of endothelin-converting enzyme (ECE), neutral endopeptidase (NEP) and mast cell chymase as processors of the endothelin (ET) analogues ET-1(1-21), ET-1(1-31) and big ET-1 in the trachea of allergic mice. Male CBA/CaH mice were sensitized with ovalbumin (10 microg) delivered intraperitoneal on days 1 and 14, and exposed to aerosolized ovalbumin on days 14, 25, 26 and 27 (OVA mice). Mice were killed and the trachea excised for histological analysis and contraction studies on day 28. Tracheae from OVA mice had 40% more mast cells than vehicle-sensitized mice (sham mice). Ovalbumin (10 microg/ml) induced transient contractions (15+/-3% of the C(max)) in tracheae from OVA mice. The ECE inhibitor CGS35066 (10 microM) inhibited contractions induced by big ET-1 (4.8-fold rightward shift of dose-response curve; P<0.05), but not those induced by either ET-1(1-21) or ET-1(1-31). The chymase inhibitors chymostatin (10 microM) and Bowman-Birk inhibitor (10 microM) had no effect on contractions induced by any of the ET analogues used. The NEP inhibitor CGS24592 (10 microM) inhibited contractions induced by ET-1(1-31) (6.2-fold rightward shift; P<0.05) but not ET-1(1-21) or big ET-1. These data suggest that big ET-1 is processed predominantly by a CGS35066-sensitive ECE within allergic airways rather than by mast cell-derived proteases such as chymase. If endogenous ET-1(1-31) is formed within allergic airways, it is likely to undergo further conversion by NEP to more active products.

  10. Behçet syndrome: from pathogenesis to novel therapies.

    PubMed

    Mazzoccoli, Gianluigi; Matarangolo, Angela; Rubino, Rosa; Inglese, Michele; De Cata, Angelo

    2016-02-01

    Behçet syndrome is a chronic disease hallmarked by inflammation of the blood vessels that is related to an autoimmune reaction caused by inherited susceptibility due to specific genes and environmental factors, probably components of infectious microorganisms, which turn on or get going the disease in genetically susceptible subjects. The more common clinical expression of the disease is represented by a triple-symptom complex of recurrent oral aphthous ulcers, genital ulcers, and uveitis, sometimes associated with inflammatory arthritis, phlebitis, iritis, as well as inflammation of the digestive tract, brain, and spinal cord. The treatment strategies used to manage the manifestations of Behçet syndrome have gradually progressed, and a number of new therapeutic resources have been implemented in recent years, allowing better control of pathogenic mechanisms, reducing symptoms and suffering, and ameliorating patient's outcome.

  11. Regret and Responsibility: A Reply to Zeelenberg et al. (1998).

    PubMed

    Ordóñez; Connolly

    2000-01-01

    M. Zeelenberg, W. W. van Dijk, and A. S. R. Manstead (1998, Organizational Behavior and Human Decision Processes, 74, 254-272) recently reported an altered replication of our earlier study (T. Connolly, L. D. Ordóñez, & R. Coughlan, 1997, Organizational Behavior and Human Decision Processes, 70, 73-85) concerning the effects of decision agency on regret and outcome evaluation. Our earlier study had found no such effect, but Zeelenberg et al. did. In two new experiments, we have largely confirmed Zeelenberg et al.'s result but have shown that, contrary to most theory, regret (a) can appear even in the absence of decision agency, (b) can be unrelated to outcome evaluations, and (c) may be more influenced by the experience of gains or losses from the status quo than by any decisional responsibility for those changes. Copyright 2000 Academic Press.

  12. STS-29 Discovery, OV-103, external tank (ET) separation

    1989-03-13

    STS029-72-059 (13 March 1989) --- This 70mm photograph, taken by Astronaut James P. Bagian 16 minutes and 7 seconds after liftoff of Discovery, shows the external fuel tank (ET) against the background of Earth. The tank is falling away from the orbiter following ET separation. The left side shows the burn scar above the solid rocket booster (SRB) forward attach point. The burn is caused by the forward SRB separation motors firing during SRB separation. Post 51-L analysis of the thermal and pressure effects of the separation motor exhaust plume indicate that the scarring is not a safety hazard. However, photographs such as this one were requested for additional missions in order to document the phenomenon and corroborate this conclusion. The photo was made at 15:13:07 GMT, March 13, 1989. It was among the visuals used by the crew at its Mar. 28, 1989 post-flight press conference.

  13. MaGnET: Malaria Genome Exploration Tool.

    PubMed

    Sharman, Joanna L; Gerloff, Dietlind L

    2013-09-15

    The Malaria Genome Exploration Tool (MaGnET) is a software tool enabling intuitive 'exploration-style' visualization of functional genomics data relating to the malaria parasite, Plasmodium falciparum. MaGnET provides innovative integrated graphic displays for different datasets, including genomic location of genes, mRNA expression data, protein-protein interactions and more. Any selection of genes to explore made by the user is easily carried over between the different viewers for different datasets, and can be changed interactively at any point (without returning to a search). Free online use (Java Web Start) or download (Java application archive and MySQL database; requires local MySQL installation) at http://malariagenomeexplorer.org joanna.sharman@ed.ac.uk or dgerloff@ffame.org Supplementary data are available at Bioinformatics online.

  14. MaGnET: Malaria Genome Exploration Tool

    PubMed Central

    Sharman, Joanna L.; Gerloff, Dietlind L.

    2013-01-01

    Summary: The Malaria Genome Exploration Tool (MaGnET) is a software tool enabling intuitive ‘exploration-style’ visualization of functional genomics data relating to the malaria parasite, Plasmodium falciparum. MaGnET provides innovative integrated graphic displays for different datasets, including genomic location of genes, mRNA expression data, protein–protein interactions and more. Any selection of genes to explore made by the user is easily carried over between the different viewers for different datasets, and can be changed interactively at any point (without returning to a search). Availability and Implementation: Free online use (Java Web Start) or download (Java application archive and MySQL database; requires local MySQL installation) at http://malariagenomeexplorer.org Contact: joanna.sharman@ed.ac.uk or dgerloff@ffame.org Supplementary information: Supplementary data are available at Bioinformatics online. PMID:23894142

  15. Intermittent turbulence and turbulent structures in LAPD and ET

    NASA Astrophysics Data System (ADS)

    Carter, T. A.; Pace, D. C.; White, A. E.; Gauvreau, J.-L.; Gourdain, P.-A.; Schmitz, L.; Taylor, R. J.

    2006-12-01

    Strongly intermittent turbulence is observed in the shadow of a limiter in the Large Plasma Device (LAPD) and in both the inboard and outboard scrape-off-layer (SOL) in the Electric Tokamak (ET) at UCLA. In LAPD, the amplitude probability distribution function (PDF) of the turbulence is strongly skewed, with density depletion events (or "holes") dominant in the high density region and density enhancement events (or "blobs") dominant in the low density region. Two-dimensional cross-conditional averaging shows that the blobs are detached, outward-propagating filamentary structures with a clear dipolar potential while the holes appear to be part of a more extended turbulent structure. A statistical study of the blobs reveals a typical size of ten times the ion sound gyroradius and a typical velocity of one tenth the sound speed. In ET, intermittent turbulence is observed on both the inboard and outboard midplane.

  16. Le syndrome des enfants battus: aspects cliniques et radiologiques

    PubMed Central

    Jlalia, Zied; Znaigui, Talel; Smida, Mahmoud

    2016-01-01

    La maltraitance physique des enfants ou le syndrome des enfants battus est responsable de plus de 75.000 décès par an en France. Ce problème de santé publique reste sous diagnostiqué en Tunisie et dans le monde. Le chemin a été laborieux pour la reconnaissance du syndrome des enfants battus dans certaines sociétés même occidentales. Nous avons voulus exposer ce problème aux praticiens afin qu'il soit mieux diagnostiqué et pris en charge. La maltraitance physique des enfants est appelée à tort syndrome de Silverman qui ne regroupe en fait que les lésions squelettiques chez ces enfants tels que les fractures. Mots clés: Fracture, maltraitance, enfant, neuro-radiologie PMID:27642408

  17. Photocopy of drawing. VAB HB2 & 4 ET HOLDING CELLS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing. VAB HB-2 & 4 ET HOLDING CELLS, UPGRADE TO CHECKOUT CELLS. NASA John F. Kennedy Space Center, Florida. File Number 79K33180, Reynolds, Smith & Hill, February 1991. H.B.-2, PLANS AT LEVELS 4,5,&6. Sheet 7 - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

  18. Photocopy of drawing. VAB HB2 & 4 ET HOLDING CELLS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing. VAB HB-2 & 4 ET HOLDING CELLS, UPGRADE TO CHECKOUT CELLS. NASA John F. Kennedy Space Center, Florida. File Number 79K33180, Reynolds, Smith & Hill, February 1991. H.B.-2, PLANS AT LEVELS 1,2,&3. Sheet 6 - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

  19. Photocopy of drawing. VAB HB2 & 4 ET HOLDING CELLS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing. VAB HB-2 & 4 ET HOLDING CELLS, UPGRADE TO CHECKOUT CELLS. NASA John F. Kennedy Space Center, Florida. File Number 79K33180, Reynolds, Smith & Hill, February 1991. H.B.-2, PLANS AT LEVELS 7,8,&9. Sheet 8 - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

  20. Photocatalytic Activity of Vanadium-Substituted ETS-10

    SciT

    Nash,M.; Rykov, S.; Lobo, R.

    2007-01-01

    Various amounts of vanadium have been isomorphously substituted for titanium in ETS-10, creating samples with V/(V+Ti) ratios of 0.13, 0.33, 0.43, and 1.00 and characterized experimentally using Raman, near-edge X-ray absorption fine structure (NEXAFS), X-ray powder diffraction, N{sub 2} adsorption, scanning electron microscopy (SEM), UV/vis spectroscopy, and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS). Raman spectra reveal a disordered chain structure that contains different V-O bonds along with the presence of a V-O-Ti peak. The UV/vis spectra of the vanadium samples have three new absorption features in the visible region at 450, 594, and 850 nm, suggesting both V{sup 4+}more » and V{sup 5+} are present in the samples. NEXAFS results confirm the presence of both V{sup 5+} and V{sup 4+} in the vanadium samples, with a fraction of V{sup 4+} within the range of 0.2-0.4. The addition of vanadium lowers the band gap energy of ETS-10 from 4.32 eV to a minimum of 3.58 eV for the 0.43ETVS-10 sample. Studies of the photocatalytic polymerization of ethylene show that the 594 nm transition has no photocatalytic activity. The visible transition around 450 nm in the vanadium-incorporated samples is photocatalytically active, and the lower-concentration vanadium samples have higher photocatalytic activity than that of ETS-10 and AM-6, the all-vanadium analogue of ETS-10.« less

  1. 76 FR 35882 - Paulding Wind Farm II, LLC, et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    ... Wind Farm II, LLC, et al.; Notice of Effectiveness of Exempt Wholesale Generator Status Docket Nos. Paulding Wind Farm II LLC EG11-61-000 Macho Springs Power I, LLC EG11-63-000 Alta Wind III Owner Lessor A EG11-64-000 Alta Wind III Owner Lessor B EG11-65-000 Alta Wind III Owner Lessor C EG11-66-000 Alta Wind...

  2. Climate and ET: Does Plant Water Requirements Increase during Droughts?

    NASA Astrophysics Data System (ADS)

    Fipps, G.

    2015-12-01

    Municipalities, engineering consultants and State agencies use reference evapotranspiration (ETo) data (directly and indirectly) for long-term water planning, for designing hydraulic structures, and for establishing regulatory guidance and conservation programs intended to reduce water waste. The use ETo data for agricultural and landscape irrigation scheduling is becoming more common in Texas as ETo-based controllers and automation technologies become more affordable. Until recently, most ETo data has been available as monthly values averaged over many years. Today, automated weather stations and irrigation controllers equipped with specialized instrumentation allow for real-time ETo measurements. With the expected rise in global warming and increased frequency of extreme climate variability in the coming decades, conservation and efficient use of water resources is essential and must make use of the most accurate and representative data available. 2011 marked the driest year on record in the State of Texas. Compounding the lack of rainfall was record heat during the Summer of 2011. An analysis of real time ETo (reference evapotranspiration) data in Texas found that ET was 30 to 50% higher than historic averages during the 2011 Summer. The implications are quite serious, as most current water planning and drought contingency plans do not take into consideration increases in ET during such periods, and irrigation planning and capacity sizing are based on historic averages of consumptive use. This paper examines the relationship between ET and climate during this extreme climatic event. While the solar radiation was near normal levels, temperature and wind was much higher and dew points much lower than norms. The variability and statistical difference between average monthly ETo data and daily, monthly and seasonal ETo measurements (from 2006 to 2014) for selected weather stations of the Texas ET Network. This study will also examine the suitability of using average

  3. Alkaloids from Mongolian species Hypecoum lactiflorum Kar. et Kir. Pazij.

    PubMed

    Philipov, Stefan; Istatkova, Ralitsa; Denkova, Pavletta; Dangaa, Selenge; Samdan, Javzan; Krosnova, Marieta; Munkh-Amgalan, Chogsom

    2009-01-01

    A new secoberbine alkaloid (-)-N-methylcorydalisol was isolated from the aerial parts of Hypecoum lactiflorum Kar. et Kir. Pazij. (Papaveraceae) of Mongolian origin and was characterised. The known alkaloids of protopine and protoberberine type protopine, allocryptopine, (-)-N-methylcanadine and (-)-N-methylstylopine were also isolated. (-)-N-methylstylopine is a new alkaloid for the genus, while (-)-N-methylcanadine is new for the species. All structures were established by physical and spectral analysis.

  4. Dynamique moléculaire et canaux ioniques

    NASA Astrophysics Data System (ADS)

    Crouzy, S.

    2005-11-01

    Diffusion de neutrons et Dynamique Moléculaire (DM) sont deux techniques intimement liées car elles portent sur les mêmes échelles de temps: la première apporte des informations structurales ou dynamiques sur le système physique ou biologique, la seconde permet de décoder ces informations à travers un modèle facilitant l'interprétation des résultats. Au delà de l'intérêt que la technique de DM peut avoir en relation directe avec les neutrons, il est intéressant de comprendre comment les modèles sont construits et comment les techniques de simulation peuvent aller beaucoup plus loin que de simples modélisations. Nous décrirons brièvement, dans la suite de cet exposé, la technique de DM et les méthodes plus sophistiquées de calculs d'énergie libre et de potentiels de force moyenne à partir des simulations de DM. Puis nous verrons avec deux exemples tirés de nos travaux théoriques sur les canaux ioniques comment ces calculs peuvent nous donner accès à des vitesses de réaction ou des constantes d'affinité ou de liaison. La première étude porte sur un analogue de la gramicidine A qui forme un canal conducteur d'ions interrompus par le basculement d'un cycle dioxolane [1]. La seconde concerne le canal potassique KcsA dont nous avons étudié le blocage du coté extracellulaire par l'ion Tetra Ethyl Ammonium [2].

  5. Behçet syndrome: a contemporary view.

    PubMed

    Yazici, Hasan; Seyahi, Emire; Hatemi, Gulen; Yazici, Yusuf

    2018-02-01

    The presence of symptom clusters, regional differences in disease expression and similarities with, for example, Crohn's disease suggest multiple pathological pathways are involved in Behçet syndrome. These features also make formulating disease criteria difficult. Genetic studies have identified HLA-B*51 to be the important genetic risk factor. However, the low prevalence of HLA-B*51 in many patients with bone fide disease, especially in non-endemic regions, suggests other factors must also be operative in Behçet syndrome. This consideration is also true for the newly proposed 'MHC-I-opathy' concept. Despite lacking a clear aetiological mechanism and definition, management of manifestations that include major vascular disease (such as Budd-Chiari syndrome and pulmonary artery involvement), eye disease and central nervous system involvement has improved with the help of new technology. Furthermore, even with our incomplete understanding of disease mechanisms, the prognoses of patients with Behçet syndrome, including those with eye disease, continue to improve.

  6. Acides gras oméga-3 et dyslexie

    PubMed Central

    Zelcer, Michal; Goldman, Ran D.

    2015-01-01

    Résumé Question À la lumière de la hausse du nombre d’enfants d’âge scolaire ayant reçu un diagnostic de dyslexie, quel est le rôle des suppléments d’acides gras oméga-3 dans la prise en charge de cette affection? Réponse La dyslexie est le trouble d’apprentissage le plus répandu et elle est connue pour ses causes multifactorielles. De récentes données probantes pointent vers une corrélation entre le métabolisme défectueux des acides gras polyinsaturés et les troubles de neurodéveloppement, tels que la dyslexie. Bien que l’administration de suppléments d’acides gras oméga-3 aux enfants dyslexiques ait fait l’objet d’études, les données probantes sont limitées. Les critères diagnostiques homogènes de dyslexie, les mesures objectives de carence en acides gras et la surveillance étroite de l’apport alimentaire ne sont que quelques-uns des facteurs pouvant améliorer la qualité de la recherche dans ce domaine.

  7. Life story of Dr. Hulusi Behçet.

    PubMed

    Saylan, T

    1997-12-01

    Dr. Hulusi Behçet was born on February 20, 1889 in Istanbul. He graduated from Gülhane Military Medical Academy in 1910 and then he specialized in Dermatology and Venereal Diseases. He served in the Edirne Military Hospital between 1914-1918 and then went to Budapest and Berlin to improve his knowledge. In 1923, he started at the Istanbul Medical Faculty as an academic staff and with university reform in 1933, he was appointed as a professor to Department of Dermatology and Venereal Diseases and continued his career there until his death in 1948. Three patients whom he had consulted for years and who shared similar symptoms made him suspect a new disease and a viral etiology which may play a role in the appearance of this disease. After several discussions and publications, medical literature had accepted Behçet's Disease as a special entity. Dr. Behçet published a total of 196 articles, 53 of which were published in prestigious international journals.

  8. External Tank (ET) Bipod Fitting Bolted Attachment Locking Insert Performance

    NASA Technical Reports Server (NTRS)

    Larsen, Curtis E.; Wilson, Tim R.; Elliott, Kenny B.; Raju, Ivatury S.; McManamen, John

    2008-01-01

    Following STS-107, the External Tank (ET) Project implemented corrective actions and configuration changes at the ET bipod fitting. Among the corrective actions, the existing bolt lock wire which provided resistance to potential bolt rotation was removed. The lock wire removal was because of concerns with creating voids during foam application and potential for lock wire to become debris. The bolts had been previously lubricated to facilitate assembly but, because of elimination of the lock wire, the ET Project wanted to enable the locking feature of the insert. Thus, the lubrication was removed from bolt threads and instead applied to the washer under the bolt head. Lubrication is necessary to maximize joint pre-load while remaining within the bolt torque specification. The locking feature is implemented by thread crimping in at four places in the insert. As the bolt is torqued into the insert the bolt threads its way past the crimped parts of the insert. This provides the locking of the bolt, as torque is required to loosen the joint after clamping.

  9. Potential role for ET-2 acting through ETA receptors in experimental colitis in mice.

    PubMed

    Claudino, R F; Leite, D F; Bento, A F; Chichorro, J G; Calixto, J B; Rae, G A

    2017-02-01

    This study attempted to clarify the roles of endothelins and mechanisms associated with ET A /ET B receptors in mouse models of colitis. Colitis was induced by intracolonic administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS, 1.5 mg/animal) or dextran sulfate sodium (DSS, 3%). After colitis establishment, mice received Atrasentan (ET A receptor antagonist, 10 mg/kg), A-192621 (ET B receptor antagonist, 20 mg/kg) or Dexamethasone (1 mg/kg) and several inflammatory parameters were assessed, as well as mRNA levels for ET-1, ET-2 and ET receptors. Atrasentan treatment ameliorates TNBS- and DSS-induced colitis. In the TNBS model was observed reduction in macroscopic and microscopic score, colon weight, neutrophil influx, IL-1β, MIP-2 and keratinocyte chemoattractant (KC) levels, inhibition of adhesion molecules expression and restoration of IL-10 levels. However, A192621 treatment did not modify any parameter. ET-1 and ET-2 mRNA was decreased 24 h, but ET-2 mRNA was markedly increased at 48 h after TNBS. ET-2 was able to potentiate LPS-induced KC production in vitro. ET A and ET B receptors mRNA were increased at 24, 48 and 72 h after colitis induction. Atrasentan treatment was effective in reducing the severity of colitis in DSS- and TNBS-treated mice, suggesting that ET A receptors might be a potential target for inflammatory bowel diseases.

  10. Reconstruction du Flux d'Energie et Recherche de Squarks et Gluinos dans l'Experience D0 (in French)

    SciT

    Ridel, Melissa

    2002-01-01

    Le modèle standard décrit la matière et les interactions fondamentales qui la gouvernent (électromagnétique, faible et forte). L'analyse des données accumulées jusqu'à présent conffrme ces prédictions notamment les mesures de précision effectuées à LEP. Malgré tout, il doit se confronter à quelques dicultés théoriques qui laisseraient penser que le Modèle Standard n'est que la théorie effective d'une autre théorie à plus haute énergie....

  11. Symetries et integrabilite des equations aux differences finies

    NASA Astrophysics Data System (ADS)

    Lafortune, Stephane

    2000-09-01

    La présente thèse porte sur l'étude des symétries et des propriétés d'intégrabilité des équations aux différences finies. Dans le chapitre 1, le groupe de symétrie ponctuelle d'un système couplé à deux équations différentielles aux différences est étudié. On montre que dans certains cas, la dimension du groupe peut être infinie. Les équations peuvent décrire l'interaction de deux longues chaînes moléculaires, chacune étant composée d'atomes d'un même type. Dans le chapitre 2, une classe de théories de champs avec interaction exponentielle est introduite. L'interaction dépend de deux matrices de ``couplage'' et est suffisamment générale pour inclure toutes les théories de champs de Toda existant dans la littérature. Les symétries de Lie ponctuelles sont obtenues pour les cas où l'on a un nombre fini, infini ou semi-infini de champs. Une attention spéciale est accordée à la présence de l'invariance conforme. Dans le chapitre 3, nous procédons à la classification et à l'étude d'équations linéarisables. Nous examinons tout d'abord l'équation de Gambier continue qui contient, comme réductions, toutes les équations de deuxième ordre intégrables par linéarisation. Nous introduisons par la suite la forme discrète de cette équation et obtenons les conditions d'intégrabilité à l'aide du confinement des singularités. Nous étudions aussi les différentes réductions du cas discret. De plus, nous obtenons des transformations de Schlesinger pour les équations de Gambier discrète et continue. Dans la dernière partie du chapitre, nous étudions une famille d'équations discrètes du deuxième ordre incluant des équations résolubles par linéarisation. Plusieurs cas intégrables sont obtenus. Dans le cas discret, l'étude de l'intégrabilité est faite à l'aide du confinement des singularités. Dans le chapitre 4, nous étudions un autre critère d'intégrabilité: l'entropie algébrique. Nous montrons que les r

  12. Proprietes ionochromes et photochromes de derives du polythiophene

    NASA Astrophysics Data System (ADS)

    Levesque, Isabelle

    La synthese et la caracterisation de derives regioreguliers du polythiophene ont ete effectuees en solution et sur des films minces. La spectroscopie UV-visible de ces derives a permis de constater qu'ils peuvent posseder des proprietes chromiques particulieres selon le stimulus auquel ils sont soumis. Par exemple, une augmentation de la temperature permet en effet aux polymeres de passer d'une couleur violette a jaune, et ce, a l'etat solide aussi bien qu'en solution. Ces proprietes chromiques semblent regies par une transition conformationnelle (plane a non-plane) de la chaine principale. Ce travail avait pour but de mieux comprendre l'influence de l'organisation des chaines laterales sur les transitions chromiques. Deux derives synthetises possedant des chaines laterales sensibles aux cations alcalins se sont averes etre ionochromes en plus d'etre thermochromes. Il s'agit d'un polymere comportant des chaines laterales de type oligo(oxyethylene) et d'un autre comportant un groupement ether couronne specifique aux ions lithium. Les effets chromiques observes sont expliques par des interactions non-covalentes des cations avec les atomes d'oxygene des chaines laterales dans le cas du premier polymere, et par l'insertion de l'ion Li + dans la cavite de l'ether couronne dans le cas du second polymere. Ces interactions semblent provoquer une diminution de l'organisation induisant ainsi une torsion de la chaine principale. Les deux polymeres semblent specifiques a certains cations et pourraient donc servir comme detecteurs optiques. La specificite aux ions Li+ du second polymere pourrait aussi permettre la conduction ionique, en plus de la conductivite electronique caracteristique des polythiophenes, ce qui pourrait s'averer utile dans le cas de batteries legeres entierement faites de polymeres et de sels de lithium. D'autres derives comportant des chaines laterales de type azobenzene se sont averes etre photochromes en plus d'etre thermochromes. Le groupement lateral a

  13. Le domaine Tariquide (arc de Gibraltar, Espagne et Maroc) : succession sédimentaire et événements structuraux au Lias et au Dogger

    NASA Astrophysics Data System (ADS)

    Durand-Delga, Michel; Gardin, Silvia; Esteras, Manuel; Paquet, Hélène

    2005-06-01

    The Lias-Dogger successions of the Tariquide units in the Gibraltar Arc differ from the series of tectonically adjacent units, the Penibetic (Iberia margin) and the Limestone 'Dorsale' (Alboran Domain). Lower Lias limestones are eroded and covered by the Domerian, which starts by deposits of open sea, continuous up to the Dogger (J. Musa-type successions), and elsewhere (Los Pastores-type successions) by a thin series (Upper Lias to Upper Dogger), starting by a manganesiferous episode (Ras Leona) and including marls deposited into three episodes, dated by calcareous nannofossils. Faulting events occurred before the Domerian and during the Late Toarcian (Los Pastores). To cite this article: M. Durand-Delga et al., C. R. Geoscience 337 (2005).

  14. Croissance des couches minces et des multicouches de matériaux supraconducteurs H Tboldmath_c : bilan et perspective

    NASA Astrophysics Data System (ADS)

    Contour, J. P.

    1994-11-01

    The main physical and chemical techniques of epitaxial growth of High T_c superconductor thin films are described together with their in situ analysis facilities and discussed with respect to their cost, sophistication and results (T_c, J_c growth defects, thickness and composition uniformity, crystallinity, electronic applications...). The future trends of the growth machines are then examined in connection with the present results and the development of superconductor electronics. Après la présentation des principales techniques de croissance physique et physicochimique de couches minces d'oxydes supraconducteurs à haute température critique, un bilan des résultats sera dressé par rapport aux différentes propriétés des films (transition résistive, courant critique, défauts de croissance, uniformité d'épaisseur et de composition, cristallinité...), aux difficultés de mise en œuvre et au coût de l'expérience. Les perspectives des différentes techniques seront ensuite examinées dans le cadre du développement potentiel d'une électronique utilisant les matériaux supraconducteurs H T_c.

  15. Etude du comportement et de la modélisation viscoplastique du zircaloy 4recristallisé sous chargements monotones et cycliques uni et multiaxes

    NASA Astrophysics Data System (ADS)

    Delobelle, P.; Robinet, P.

    1994-08-01

    The results of experiment performed on a recrystallized zircaloy 4 alloy in the intermediate temperature domain 20 leqslant T leqslant 400 ^{circ}C are presented. To characterize the anisotropy, especially at 350 ^{circ}C, the tests were made under both monotonic and cyclic uni- and bidirectional loadings, i.e. tension-compression, tension-torsion and tension-internal pressure tests. The different anisotropy coefficients and especially R^p = \\varepsilon^p_{θθ} /\\varepsilon^ p _ {{^-_-}{^-_-} } seem to be temperature independent. An important feature of the behavior of this alloy in the neighbourhood of 300 ^{circ}C is attributed to the dislocations-point defects interactions (dynamic strain aging), phenomena often observed in the solid solutions. For the 2D cyclic non proportional loadings it is shown that a weak supplementary hardening appears, which is a function of the degree of the phase lag. We propose to particularize and to apply a unified viscoplastic model with internal variables to the considered alloy, as the model as already been developed and identified elsewhere for other isotropic materials. From a general point of view the introduction of the anisotropy in the model is made by four tensors of rank 4 ; [ M] is assigned to the flow directions, [ N] to the linear parts of the kinematical hardening variables and [ Q] , [ R] respectively to the dynamic and static recoveries of these tensorial variables. This phenomenological formulation leads to a correct representation of the set of the experimental results presented at 350 ^{circ}C, which provides an a posteriori confirmation of the formalism used. On étudie, entre 20 et 400 ^{circ}C, à l'aide d'essais sous chargements multiaxiaux monotones et cycliques (traction, torsion et pression interne) les propriétés viscoplastiques anisotropes de tube de zircaloy 4 recristallisé. A la température de 350 ^{circ}C, l'anisotropie a été quantifiée de façon détaillée. Les quelques résultats obtenus

  16. Le changement comme tradition dans la recherche et la formation a la recherche en biotechnologie et en peripherie Etude de cas en sciences de la sante, sciences naturelles et genie

    NASA Astrophysics Data System (ADS)

    Bourque, Claude Julie

    Le champ de la recherche scientifique et de la formation a la recherche est traverse depuis quelques dizaines d'annees par plusieurs courants et discours associes au changement, mais peu de travaux empiriques permettent de comprendre ce qui change concretement. C'est la contribution originale de cette these au champ de l'education, plus specifiquement a l'etude sociologique de l'enseignement superieur ou sont concentrees les activites liees a la triade thematique du programme doctoral dans lequel elle a ete produite : recherche, formation et pratique. L'enquete-terrain a ete realisee en 2009 et 2010 aupres de 808 repondants affilies a 60 etablissements au Quebec et a produit un vaste materiau de nature mixte (donnees quantitatives et qualitatives). Un portrait de la nebuleuse biotechnologique qui touche les secteurs des sciences de la sante, des sciences naturelles et du genie a ete realise. Ce domaine concerne des dizaines de disciplines et se revele de nature transdisciplinaire, mais les pratiques n'y sont pas davantage marquees par le changement que celles d'autres domaines connexes. Les dynamiques sociales ont fait l'objet d'analyses comparatives dans quatre contextes: le choix des programmes, des objets et des methodes, le financement, la diffusion et la planification de la carriere. Les resultats indiquent que les echanges entre les agents traditionnellement situes au coeur des activites de recherche dominent ces dynamiques dans tous les contextes etudies. L'etude des representations au fondement des pratiques a revele l'existence de trois ecoles de pensee qui coexistent dans le champ scientifique: academique, pragmatique et economiste. Ces ecoles permettent de categoriser les agents en fonction des zones de fractures qui marquent leurs oppositions tout en identifiant ce qu'ils ont en commun. Les representations et les pratiques liees a la formation temoignent d'un habitus plutot homogene, alors que les contradictions semblent plus souvent ancrees dans des

  17. Effets Josephson generalises entre antiferroaimants et entre supraconducteurs antiferromagnetiques

    NASA Astrophysics Data System (ADS)

    Chasse, Dominique

    L'effet Josephson est generalement presente comme le resultat de l'effet tunnel coherent de paires de Cooper a travers une jonction tunnel entre deux supraconducteurs, mais il est possible de l'expliquer dans un contexte plus general. Par exemple, Esposito & al. ont recemment demontre que l'effet Josephson DC peut etre decrit a l'aide du boson pseudo-Goldstone de deux systemes couples brisant chacun la symetrie abelienne U(1). Puisque cette description se generalise de facon naturelle a des brisures de symetries continues non-abeliennes, l'equivalent de l'effet Josephson devrait donc exister pour des types d'ordre a longue portee differents de la supraconductivite. Le cas de deux ferroaimants itinerants (brisure de symetrie 0(3)) couples a travers une jonction tunnel a deja ete traite dans la litterature Afin de mettre en evidence la generalite du phenomene et dans le but de faire des predictions a partir d'un modele realiste, nous etudions le cas d'une jonction tunnel entre deux antiferroaimants itinerants. En adoptant une approche Similaire a celle d'Ambegaokar & Baratoff pour une jonction Josephson, nous trouvons un courant d'aimantation alternee a travers la jonction qui est proportionnel a sG x sD ou fG et sD sont les vecteurs de Neel de part et d'autre de la jonction. La fonction sinus caracteristique du courant Josephson standard est donc remplacee.ici par un produit vectoriel. Nous montrons que, d'un point de vue microscopique, ce phenomene resulte de l'effet tunnel coherent de paires particule-trou de spin 1 et de vecteur d'onde net egal au vecteur d'onde antiferromagnetique Q. Nous trouvons egalement la dependance en temperature de l'analogue du courant critique. En presence d'un champ magnetique externe, nous obtenons l'analogue de l'effet Josephson AC et la description complete que nous en donnons s'applique aussi au cas d'une jonction tunnel entre ferroaimants (dans ce dernier cas, les traitements anterieurs de cet effet AC s'averent incomplets). Nous

  18. Suicidal ideation among patients with Behçet's syndrome.

    PubMed

    Saygin, Caner; Uzunaslan, Didem; Hatemi, Gulen; Hamuryudan, Vedat

    2015-01-01

    To evaluate the frequency of suicidal ideation among Behçet's syndrome (BS) patients compared to healthy and diseased controls and to delineate possible factors predicting an increase in suicidal ideation. We included consecutive BS patients attending our outpatient clinic, patients with ankylosing spondylitis (AS) and healthy hospital staff as controls. Suicidal ideation was assessed by a standard questionnaire. Linear regression was used to identify the factors associated with suicidal ideation, such as demographic and clinical features, drugs, disease activity assessed using the Behçet's disease current activity form (BDCAF) for BS patients and BASDAI for AS patients, Behçet's disease quality of life (BDQoL) and Beck depression inventory (BDI) score. We surveyed 303 BS patients, 52 AS patients and 106 healthy controls. Suicidal thoughts, as reflected by a positive response to the first three items of the questionnaire, were higher among BS patients with major organ involvement (42%) than those with mucocutaneous involvement (35%) and the control groups. There were significantly more BS patients with active major organ involvement who had thought to terminate their lives without plans within the last year (25.5%) compared to those with active mucocutaneous involvement (8.7%) and active AS patients (10%) (p=0.012). Patient-reported joint pain (β=-0.155, p=0.046), BDQoL (β=0.176, p=0.032), and BDI (β=0.017, p<0.0001) scores, suicidal thoughts before the onset of BS (β=-0.124, p=0.043), neurologic involvement (β=0.119, p=0.047) and past prednisone use (β=0.212, p=0.005) were independent predictors of suicidal thoughts. BS patients with major organ involvement have increased thoughts of suicide during the active stages of their disease. A number of risk factors could help physicians to identify patients with increased suicidal thoughts.

  19. Climate and ET: Does Plant Water Requirements Increase during Droughts?

    NASA Astrophysics Data System (ADS)

    Fipps, G.; Bonaiti, G.; Swanson, C.

    2012-04-01

    With the expected rise in global warming and increased frequency of extreme climate variability in the coming decades, conservation and efficient use of water resources is essential and must make use of the most accurate and representative data available. Historically, governmental and private organizations have used estimates of plant water use estimated from a variety of methods for long-term water planning, for designing hydraulic structures, and for establishing regulatory guidance and conservation programs intended to reduce water waste. In recent years, there has been an expansion of agricultural weather station networks which report daily ETo (potential evapotranspiration) and commercial irrigation controllers with instrumentation which calculate real-time ETo from weather parameters. Efforts are underway to use this more precise information for regional water planning and ETo is routinely used for designing and implementing drought response programs. The year 2011 marked the driest year on record in the State of Texas. Compounding the lack of rainfall was record heat during the summer of 2011. In 2011, real-time ETo (reference evapotranspiration) data in Texas was 30 to 50% higher than historic averages. The implications are quite serious, as most current water planning and drought contingency plans do not take into consideration increases in ET during such periods, and irrigation planning and capacity sizing are based on historic averages of consumptive use. This paper examines the relationship between ET and climate during this extreme climatic event. While the solar radiation was near normal levels, temperature and wind was much higher and dew points much lower than norms. The variability and statistical difference between long term average ETo and ETo measurements (from 2006 to 2011) for selected weather stations of the Texas ET Network.

  20. 41 CFR 301-73.101 - How must we prepare to implement ETS?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... to implement ETS as expeditiously as possible by— (a) Developing a migration plan and schedule to... allocate budget and personnel resources to support ETS migration and data exchange. Your agency is...

  1. 41 CFR 301-73.101 - How must we prepare to implement ETS?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... to implement ETS as expeditiously as possible by— (a) Developing a migration plan and schedule to... allocate budget and personnel resources to support ETS migration and data exchange. Your agency is...

  2. 41 CFR 301-73.101 - How must we prepare to implement ETS?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... to implement ETS as expeditiously as possible by— (a) Developing a migration plan and schedule to... allocate budget and personnel resources to support ETS migration and data exchange. Your agency is...

  3. Cellules solaires photovoltaïques plastiques enjeux et perspectives

    NASA Astrophysics Data System (ADS)

    Sicot, L.; Dumarcher, V.; Raimond, P.; Rosilio, C.; Sentein, C.; Fiorini, C.

    2002-04-01

    Après avoir détaillé le fonctionnement d'une cellule photovoltaïque plastique et les paramètres photovoltaïques permettant de caractéiser son efficacité, un état de l'art des technologies de fabrication des cellules est présenté. Des moyens d'amélioration des performances des cellules photovoltaïques organiques sont ensuite illustrés par l'étude de dispositifs développés au Laboratoire Composants Organiques (LCO) du CEA Saclay.

  4. Pityriasis lichenoides et varioliformis acuta after influenza vaccine*

    PubMed Central

    de Castro, Breno Augusto Campos; Pereira, Juliana Milagres Macedo; Meyer, Renata Leal Bregunci; Trindade, Fernanda Marques; Pedrosa, Moises Salgado; Piancastelli, André Costa Cruz

    2015-01-01

    The etiology of pityriasis lichenoides is unknown. One of the accepted theories admits that PL is an inflammatory response to extrinsic antigens such as infectious agents, drugs and vaccines. In recent medical literature, only the MMR vaccine (Measles, Mumps and Rubella) was associated with the occurrence of this disease. We present a case of a male, 12 year old healthy patient who, five days after Infl uenza vaccination, developed erythematous papules on the trunk, abdomen and limbs, some with adherent crusts and associated systemic symptoms. This case report is notable for describing the first case of pityriasis lichenoides et varioliformis acuta associated with the vaccine against Influenza. PMID:26312710

  5. Fetchamium prolixispinosum gen. et comb. nov. (division Dinoflagellata)

    NASA Astrophysics Data System (ADS)

    Pearce, Martin A.; Williams, Graham L.

    2018-01-01

    Oligosphaeridium is a gonyaulacacean dinocyst lacking cingular processes and possessing a distinctive process centred on the antapical plate indicating a sexiform hyposomal tabulation. However, specimens referable to the description of Oligosphaeridium prolixispinosum Davey and Williams, 1966, although lacking cingular processes, are clearly not sexiform. As an additional complication, the holotype of Oligosphaeridium prolixispinosum possesses cingular processes. In this brief contribution, we describe the new genus Fetchamium to accommodate the new transfer Fetchamium prolixispinosum gen. et comb. nov. and provide a discussion and emended diagnosis of the species.

  6. Severe panuveitis in neuro-Behçet's disease in Malaysia: a case series.

    PubMed

    Othman, Khairuddin; Liza-Sharmini, Ahmad Tajudin; Ibrahim, Mohtar; Tharakan, John; Yanai, Ryoji; Zunaina, Embong

    2017-01-01

    Behçet's disease (BD) is a multisystemic disease that is very rare in Malaysia. About 5% of patients develop central nervous system involvement, termed neuro-Behçet's. Neuro-Behçet's is one of the most serious causes of long-term morbidity and mortality. We report two cases of neuro-Behçet's associated with uveitis (ocular BD) highlighting the clinical presentation, diagnostic measurement, and therapeutic management of these cases.

  7. Etude de l'influence de la temperature et de l'humidite sur les proprietes mecaniques en traction des fibres de chanvre et de coco

    NASA Astrophysics Data System (ADS)

    Ho Thi, Thu Nga

    L'objectif de cette etude fut d'etablir l'effet de l'humidite et de la temperature sur la resistance en traction et le module elastique des fibres de chanvre et de coco. Deux etudes ont ete realisees afin d'atteindre cet objectif. La premiere vise l'absorption de l'humidite dans ces fibres en exposition dans l'air (de 0%RH a 80%RH) ainsi que l'absorption de l'eau dans ces fibres immergees dans l'eau aux differentes temperatures. La deuxieme consiste a mesurer la resistance en traction et le module elastique de ces fibres sous differentes conditions d'humidite et de temperature. En basant sur les resultats experimentaux obtenus, les methodes semi empiriques et de reseaux de neurones ont ete utilisees pour but de predire les proprietes en traction (resistance et module d'elasticite) des fibres de chanvre et de coco sous l'influence de l'humidite et de la temperature.

  8. Endothelin-1 (ET-1) stimulates carboxy terminal Smad2 phosphorylation in vascular endothelial cells by a mechanism dependent on ET receptors and de novo protein synthesis.

    PubMed

    Sharifat, Narges; Mohammad Zadeh, Ghorban; Ghaffari, Mohammad-Ali; Dayati, Parisa; Kamato, Danielle; Little, Peter J; Babaahmadi-Rezaei, Hossein

    2017-01-01

    G protein-coupled receptor (GPCR) agonists through their receptors can transactivate protein tyrosine kinase receptors such as epidermal growth factor receptor and serine/threonine kinase receptors most notably transforming growth factor (TGF)-β receptor (TβRI). This signalling mechanism represents a major expansion in the cellular outcomes attributable to GPCR signalling. This study addressed the role and mechanisms involved in GPCR agonist, endothelin-1 (ET-1)-mediated transactivation of the TβRI in bovine aortic endothelial cells (BAECs). The in-vitro model used BAECs. Signalling intermediate phospho-Smad2 in the carboxy terminal was detected and quantified by Western blotting. ET-1 treatment of BAECs resulted in a time and concentration-dependent increase in pSmad2C. Peak phosphorylation was evident with 100 nm treatment of ET-1 at 4-6 h. TβRI antagonist, SB431542 inhibited ET-1-mediated pSmad2C. In the presence of bosentan, a mixed ET A and ET B receptor antagonist ET-1-mediated pSmad2C levels were inhibited. The ET-mediated pSmad2C was blocked by the protein synthesis inhibitor, cycloheximide. In BAECs, ET-1 via the ETB receptor is involved in transactivation of the TβRI. The transactivation-dependent response is dependent upon de novo protein synthesis. © 2016 Royal Pharmaceutical Society.

  9. L'etude de l'InP et du GaP suite a l'implantation ionique de Mn et a un recuit thermique

    NASA Astrophysics Data System (ADS)

    Bucsa, Ioan Gigel

    Cette these est dediee a l'etude des materiaux InMnP et GaMnP fabriques par implantation ionique et recuit thermique. Plus precisement nous avons investigue la possibilite de former par implantation ionique des materiaux homogenes (alliages) de InMnP et GaMnP contenant de 1 a 5 % atomiques de Mn qui seraient en etat ferromagnetique, pour des possibles applications dans la spintronique. Dans un premier chapitre introductif nous donnons les motivations de cette recherche et faisons une revue de la litterature sur ce sujet. Le deuxieme chapitre decrit les principes de l'implantation ionique, qui est la technique utilisee pour la fabrication des echantillons. Les effets de l'energie, fluence et direction du faisceau ionique sur le profil d'implantation et la formation des dommages seront mis en evidence. Aussi dans ce chapitre nous allons trouver des informations sur les substrats utilises pour l'implantation. Les techniques experimentales utilisees pour la caracterisation structurale, chimique et magnetique des echantillons, ainsi que leurs limitations sont presentees dans le troisieme chapitre. Quelques principes theoriques du magnetisme necessaires pour la comprehension des mesures magnetiques se retrouvent dans le chapitre 4. Le cinquieme chapitre est dedie a l'etude de la morphologie et des proprietes magnetiques des substrats utilises pour implantation et le sixieme chapitre, a l'etude des echantillons implantes au Mn sans avoir subi un recuit thermique. Notamment nous allons voir dans ce chapitre que l'implantation de Mn a plus que 1016 ions/cm 2 amorphise la partie implantee du materiau et le Mn implante se dispose en profondeur sur un profil gaussien. De point de vue magnetique les atomes implantes se trouvent dans un etat paramagnetique entre 5 et 300 K ayant le spin 5/2. Dans le chapitre 7 nous presentons les proprietes des echantillons recuits a basses temperatures. Nous allons voir que dans ces echantillons la couche implantee est polycristalline et les

  10. Calendar of Selected Aeronautical and Space Meetings (Calendrier des Manifestations Aeronautiques et Spatiales (Selection))

    DTIC Science & Technology

    1989-01-01

    Structurces, Matdriaux et MWcanique appliqu&c 53 08 - Physique de U’Atmosph~re et Environnement terrestre 73 09 -Information, Documentation et Informatique 77...CO 80840 US UTIIS University of Tokyo Institute of Industrial Science: 7-22-1 Roppongi, Minato-ku, Tokyo 106 JA VDE Verband Deutscher

  11. Calendar of Selected Aeronautical & Space Meetings (Calendrier des Manifestations Aeronautiques et Spatiales (Selection)).

    DTIC Science & Technology

    1986-07-01

    de l’Atmospbhre et Environnement terrestre 68 09 - Information, Documentation et Informatique 73 10 - Themes g~n~raux (pluridisciplinaires) et divers...76019 US VDE Verband Deutscher Elektrotechniker: Zentrastelle Tagungen, Stresemannallee 21, D-6000 Frankfurt-am-Main 70 GE VDI Verein Deutscher

  12. Calendar of Selected Aeronautical and Space Meetings (Calendrier des Manifestations Aeronautiques et Spatiales (Selection)).

    DTIC Science & Technology

    1983-07-01

    Structures, Matiriaux et Micanique appliquie 51 08 - Physique de l’Atmosphire et Environnement terrestre 70 09 - Information, Documentation et...78712 US VDE Verband Deutscher Elektrotechniker: Zentralstelle Tagungen, Stresemannallee 21, D-6000 Frankfurt am Main 70 GE WEC World Energy Conference

  13. Spotted owl ecology: theory and methodology—a reply to Rosenberg et al.

    A.B. Carey

    1995-01-01

    In their remarks on the study of Spotted Owls (Strix occidentalis) by Carey et al. (1992). Rosenberg et al. (1994) questioned the appropriateness of certain analyses and methods, and specific interpretation of the results. Herein, I respond to the comments of Rosenberg et al. (1994), which are summarized in italics.Sample sizes were nor...

  14. Enhancing the value of the breeding bird survey: reply to Sauer et al. (2005)

    Charles M. Francis; Jonathan Bart; Erica H. Dunn; Kenneth P. Burnham; C. John Ralph

    2005-01-01

    Bart et al (2004a) proposed several approaches for enhancing the considerable value of the Breeding Bird Survey (BBS). Sauer et al. (2005) critiqued some of these approaches, and emphasized alternative goals for the survey. We agree with many of the suggestions of Sauer et al. (2005); notably that multispecies, large-scale surveys such as the BBS are most valuable for...

  15. Estimating missing hourly climatic data using artificial neural network for energy balance based ET mapping applications

    Remote sensing based evapotranspiration (ET) mapping is an important improvement for water resources management. Hourly climatic data and reference ET are crucial for implementing remote sensing based ET models such as METRIC and SEBAL. In Turkey, data on all climatic variables may not be available ...

  16. [Neurological manifestations of Behçet's disease].

    PubMed

    Noel, N; Drier, A; Wechsler, B; Piette, J-C; De Paz, R; Dormont, D; Cacoub, P; Saadoun, D

    2014-02-01

    Neurological manifestations of Behçet's disease (BD) occur in 5.3 to more than 50% of patients. They are divided into two major forms: "parenchymal" lesions, which include mainly meningoencephalitis as opposed to "extra-parenchymal" lesions (i.e. cerebral venous thrombosis and arterial aneurysms). Myelitis or peripheral neuropathy is exceptional. The neuro-Behçet syndrome (NBS) should be considered in the setting of neurological manifestations, particularly headache and pyramidal signs, in a young man diagnosed with BD. However, its recognition may be difficult when neurological manifestations are the presenting features of BD (one third of cases), and requires a thorough knowledge of clinical manifestations and morphological lesions. Thus, parenchymal NB lesions classically exhibit inflammatory characteristics on MRI and are located at the meso-diencephalic junction and in the brainstem, rarely with a supratentorial extension. Meningitis is not systematically associated, and may be absent in about 30% of cases. The pathogenesis of these lesions is incompletely understood, but inflammatory infiltrates include mainly neutrophils and activated T cells (mainly Th17). Differential diagnoses include infectious diseases (herpes, listeria, tuberculosis), and inflammatory diseases (i.e. multiple sclerosis and sarcoidosis). A prompt recognition of NBS should lead to initiate adequate therapies in order to limit the risk of sequelae, relapses or death. Copyright © 2013. Published by Elsevier SAS.

  17. [Cardiovascular involvement in Behçet's disease].

    PubMed

    Desbois, A-C; Wechsler, B; Cluzel, P; Helft, G; Boutin, D; Piette, J-C; Cacoub, P; Saadoun, D

    2014-02-01

    Vascular involvement is a common complication of Behçet's disease (BD) and affects up to 40% of BD patients. These complications worsen the prognosis of BD. The concept of vasculo-Behçet has been adopted for cases in which vascular complications dominate the clinical features. Vascular manifestations affect particularly young men, during the first years following onset of the disease. Venous complications are the most frequent vascular complications, affecting 14 to 40% of BD patients. Superficial and deep lower limb thrombosis is the most frequent venous complications but one third of venous thrombosis concern large vessels (such as cerebral venous thrombosis, pulmonary embolism, and inferior or superior vena cava, etc.). Budd-Chiari syndrome is the worst prognostic factor increasing mortality by 9 times. Arterial complications (2 to 17% of BD patients) include aneurysms and occlusions/stenosis. Main locations of arterial lesions are aortic (abdominal and thoracic), femoral, pulmonary and iliac arteries. Aneurysms are the most severe arterial complications, particularly pulmonary aneurysms associated with a high risk of massive bleeding. Cardiac complications (up to 6% of BD patients) include pericarditis, endocardial lesions (aortic regurgitation and less often mitral insufficiency), myocardial lesions (myocardial infarction, myocarditis and endomyocardial fibrosis) and intracardiac thrombosis (right ventricle and atrium). Coronary lesions complicated to myocardial infarction are the most severe cardiac complications. Treatment is based on corticosteroids and immunosuppressive drugs. The use of anticoagulation in venous thrombosis is still controversial. Copyright © 2014. Published by Elsevier SAS.

  18. Immunopathogenesis of Ocular Behçet's Disease

    PubMed Central

    Park, Un Chul; Kim, Tae Wan; Yu, Hyeong Gon

    2014-01-01

    Behçet's disease (BD) is a chronic recurrent systemic inflammatory disorder of unknown etiology characterized by oral and genital ulcerations, skin lesions, and uveitis. The ocular involvement of BD, or Behçet's uveitis (BU), is characterized by panuveitis or posterior uveitis with occlusive retinal vasculitis and tends to be more recurrent and sight threatening than other endogenous autoimmune uveitides, despite aggressive immunosuppression. Although pathogenesis of BD is unclear, researches have revealed that immunological aberrations may be the cornerstone of BD development. General hypothesis of BD pathogenesis is that inflammatory response is initiated by infectious agents or autoantigens in patients with predisposing genetic factors and perpetuated by both innate and acquired immunity. In addition, a network of immune mediators plays a substantial role in the inflammatory cascade. Recently, we found that the immunopathogenesis of BU is distinct from other autoimmune uveitides regarding intraocular effector cell profiles, maturation markers of dendritic cells, and the cytokine/chemokine environment. In addition, accumulating evidence indicates the involvement of Th17 cells in BD and BU. Recent studies on genetics and biologics therapies in refractory BU also support the immunological association with the pathogenesis of BU. In this review, we provide an overview of novel findings regarding the immunopathogenesis of BU. PMID:25061613

  19. Behçet disease in Western Algeria.

    PubMed

    Ghembaza, M E A; Bouabdallah, N; Lounici, A

    2017-02-01

    The aim of the current study was to describe the epidemiological and clinical features of Behçet disease in western Algeria. This observational retrospective study examined records for patients with Behçet disease seen in our department from 1990 to 2015. Of the 61 patients included in the study, 80.3% were men, for a sex ratio of 4.08. The mean age at onset was 27.2±7 years, and the mean interval between the onset of symptoms and diagnosis was 4.8±6.3 years. Dermatologic manifestations were the most common finding. Oral ulcers were seen in all patients, genital ulcers in 60%, pseudofolliculitis in 56.4%, and erythema nodosum in 13.5%. A pathergy test was positive in 20% of the patients. The frequencies of the remaining manifestations were as follows: joint involvement 50%, ocular involvement 71.2%, vascular complications 29.6%, neurological involvement 19%, and gastrointestinal complications 7.5%. Besides dermatological manifestations, ocular and vascular complications were the most common features observed in our patients.

  20. Proposed Approach to Stable High Beta Plasmas in ET

    NASA Astrophysics Data System (ADS)

    Taylor, R. J.; Carter, T. A.; Gauvreau, J.-L.; Gourdain, P.-A.; Grossman, A.; Lafonteese, D. J.; Pace, D. C.; Schmitz, L. W.

    2003-10-01

    Five second long plasmas have been produced in ET with ease. We need these long pulses to evolve high beta equilibria under controlled conditions. However, equilibrium control is lost to internal disruptions due to the development of giant sawteeth on the 1 second time scale. This time scale is approximately the central energy confinement time, while the central particle confinement time is much longer than 1 second. This persistent limitation is present in ohmic and ICRF heated discharges. MHD stable current profiles have been found using DCON(A.H. Glasser, private communication) but transport related phenomena like giant sawteeth and uncontrolled transport barrier evolution are not yet part of a simple stability study. We are advocating avoiding the evolution of giant sawtooth and conditions responsible for MHD instabilities as opposed to exploring their stabilization. This is equivalent to the statement that self-organized plasmas are in fact not welcome in long pulse tokamaks. We intend to prevent self-organization by the application of a multi-faceted ICRF strategy. The in house technology is ready but the approach needs to be artful and not preconceived. The flexibility built into the ET hardware is likely to help us to find a way to achieve global plasma control. It is essential that this work be pursued geared towards parameter performance and configuration control. Both require a significant commitment to understanding the device physics AND delivering on the engineering required for control and performance.

  1. [Otorhinolaryngological manifestations in patients with Behçet disease].

    PubMed

    Morales-Angulo, Carmelo; Vergara Pastrana, Sandra; Obeso-Agüera, Sergio; Acle, Leticia; González-Gay, Miguel Ángel

    2014-01-01

    Behçet disease (BD) is a systemic immune-mediated vasculitis of unknown origin characterised by recurrent orogenital ulceration, ocular inflammation and skin lesions. The aim of our study was to identify ear, nose and throat (ENT) manifestations associated with BD. Retrospective review of the medical records of all patients diagnosed with BD who attended a tertiary public hospital in Cantabria (Spain) over a period of 22 years. Clinical manifestations, in particular those concerning ENT, were retrieved from medical records. A medical literature review of ENT manifestations was conducted. Thirty-three patients (age range: 17-64 years) were included in the study. Most of them presented oral ulcers (97%). Eight patients (24%) presented oropharyngeal ulcers and 5 patients (15%) experienced audiovestibular symptoms (high frequency sensorineural hearing loss, vertigo and bilateral vestibular hypofunction). One patient had symptoms compatible with vestibular neuronitis as the presentation manifestation of Neuro-Behçet. In 4 patients (12%) the presence of odynophagia secondary to the presence of oropharyngeal lesions, initially interpreted as acute or recurrent tonsillitis, was the first manifestation of the disease, alone or associated with cutaneous or ocular lesions. In addition to the characteristic oral ulcers present in most patients with BD, ulcers in the oropharynx, occasionally interpreted as acute pharyngitis, are also common in these patients. Audiovestibular manifestations frequently appear during the course of the disease and may be the first symptom of central nervous system involvement. Copyright © 2013 Elsevier España, S.L. All rights reserved.

  2. Laser sans mode et étoile laser

    NASA Astrophysics Data System (ADS)

    Pique, J.-P.; Farinotti, S.; Fesquet, V.

    2004-11-01

    Nous décrivons la chaîne laser étudiée dans le cadre du projet Etoile-Laser-Polychromatique pour l'Optique-Adaptative (ELP-OA). Cette chaîne est constituée d'un oscillateur sans-mode, d'un préamplificateur intra-cavité et d'un amplificateur. L'objectif fixé est : 20 W de puissance moyenne, avec un taux de répétition de 15 kHz et une largeur d'impulsion de 40 ns. Nous montrons que l'aspect sans-mode de cette chaîne permet de s'affranchir du phénomène de saturation de l'atome de sodium. Nous avons mesuré un gain de 5 sur l'intensité de l'étoile monochromatique D{2}. Un facteur 30 est attendu sur l'intensité de la composante UV de l'étoile polychromatique.

  3. Ocular Behçet disease: current therapeutic approaches.

    PubMed

    Evereklioglu, Cem

    2011-11-01

    To alert physician to timely recognition and current treatment of recurrent hypopyon iridocyclitis or panuveitis in ocular Behçet disease (OBD). Interferon-α, rituximab, intravitreal triamcinolone, and biological response modifiers by tumor necrosis factor inhibitors such as infliximab and adalimumab are being used increasingly for the treatment of severe sight-threatening ocular inflammation including retinal vasculitis and cystoid macular edema (CME). Biological agents offer tremendous potential in the treatment of OBD. Given that OBD predominantly afflicts the younger adults in their most productive years, dermatologist, rheumatologist, internist, or general practitioners supervising patients with oculo-articulo-oromucocutaneous syndromes should be aware of systemic Behçet disease. Early recognition of ocular involvement is important and such patients should strongly be instructed to visit immediately an ophthalmologist, as uveitis management differs from extraocular involvements with high ocular morbidity from sight-threatening complications due to relapsing inflammatory attacks in the posterior segment of the eye. A single infliximab infusion should be considered for the control of acute panuveitis, whereas repeated long-term infliximab infusions were proved to be more effective in reducing the number of episodes in refractory uveoretinitis with faster regression and complete remission of CME.

  4. Downscaling Coarse Actual ET Data Using Land Surface Resistance

    NASA Astrophysics Data System (ADS)

    Shen, T.

    2017-12-01

    This study proposed a new approach of downscaling ETWATCH 1km actual evapotranspiration (ET) product to a spatial resolution of 30m using land surface resistance that simulated mainly from monthly Landsat8 data and Jarvis method, which combined the benefits of both high temporal resolution of ETWATCH product and fine spatial resolution of Landsat8. The driving factor, surface resistance (Rs), was chosen for the reason that could reflect the transfer ability of vapor flow over canopy. Combined resistance Rs both upon canopy conditions, atmospheric factors and available water content of soil, which remains stable inside one ETWATCH pixel (1km). In this research, we used ETWATCH 1km ten-day actual ET product from April to October in a total of twenty-one images and monthly 30 meters cloud-free NDVI of 2013 (two images from HJ as a substitute due to cloud contamination) combined meteorological indicators for downscaling. A good agreement and correlation were obtained between the downscaled data and three flux sites observation in the middle reach of Heihe basin. The downscaling results show good consistency with the original ETWATCH 1km data both temporal and spatial scale over different land cover types with R2 ranged from 0.8 to 0.98. Besides, downscaled result captured the progression of vegetation transpiration well. This study proved the practicability of new downscaling method in the water resource management.

  5. L’évaluation et la prise en charge des enfants et des adolescents victimes d’une commotion liée à un sport

    PubMed Central

    Purcell, Laura K

    2012-01-01

    RÉSUMÉ Les commotions sont des blessures sportives fréquentes, et elles sont particulièrement courantes chez les enfants et les adolescents qui participent à des sports organisés ou à des activités récréatives. Les symptômes de commotion peuvent être subtils et négligés par les athlètes, les entraîneurs et les parents. Un enfant ou un adolescent qui est victime d’une commotion devrait être immédiatement retiré du jeu et être évalué par un médecin dans les plus brefs délais. Il devrait éviter les activités physiques et cognitives pour se remettre de la commotion. Une fois les symptômes complètement résorbés au repos, l’athlète peut suivre un protocole d’effort graduel, supervisé par un médecin, avant d’obtenir l’autorisation médicale de retourner au jeu. Il est essentiel que tous ceux qui participent aux activités sportives pour les enfants et les adolescents connaissent les signes et symptômes de commotion afin qu’on puisse poser un diagnostic exact et rapide et amorcer une évaluation et une prise en charge convenables. Le présent document de principes remplace celui qui a été publié en 2006.

  6. Human leukocyte antigen B27 and B51 double-positive Behçet uveitis.

    PubMed

    Ahn, Jae Kyoun; Park, Yeoung Geol

    2007-10-01

    To describe the clinical characteristics of human leukocyte antigen (HLA) B27 and B51 double-positive Behçet uveitis and to determine whether the coexistence of HLA-B27 can affect Behçet uveitis. We retrospectively reviewed the medical records of patients with Behçet uveitis and patients with HLA-B27-associated non-Behçet uveitis who underwent HLA-B27 and HLA-B51 typing and were followed up for more than 3 years. We divided the patients into 3 groups according to HLA-B27/B51 status and compared the clinical outcomes. Main outcome measures were demographic features, uveitis characteristics, complications, treatments, and visual prognosis. Fourteen patients with HLA-B27(+)B51(+) Behçet uveitis, 43 patients with HLA-B27(-)B51(+) Behçet uveitis, and 41 patients with HLA-B27(+)B51(-) non-Behçet uveitis were identified. HLA-B27(+)B51(+) Behçet uveitis showed the demographic features similar to HLA-B27(-) counterparts. However, HLA-B27(+)B51(+) Behçet uveitis showed less involvement of posterior segments, a less chronic course, fewer complications in posterior segments, and less use of systemic medication or surgical intervention for inflammatory control, similar to HLA-B27(+)B51(-) non-Behçet uveitis. The long-term vision prognosis of HLA-B27(+)B51(+) Behçet uveitis was more favorable than that of HLA-B27(-)B51(+) Behçet uveitis. Our results indicate that HLA-B27(+)B51(+) Behçet uveitis is a benign subgroup of Behçet uveitis. The positivity of HLA-B27 may be a good prognostic factor in Behçet uveitis.

  7. The role of infections in Behçet disease and neuro-Behçet syndrome.

    PubMed

    Marta, Monica; Santos, Ernestina; Coutinho, Ester; Silva, Ana Martins; Correia, João; Vasconcelos, Carlos; Giovannoni, Gavin

    2015-07-01

    Infections are considered an environmental trigger for exacerbations of immune-mediated diseases. We aimed to establish if common viral infections could be identified as a precipitant of Behçet disease (BD) with or without neurological involvement and to assess the variability of the immune response to common viruses. We also investigated whether cytokines and chemokines could be markers of neurological involvement. Finally, we explored if anti-basal ganglia antibodies (ABGAs) would be associated with neurological involvement in BD. Our study included 14 individuals with BD with neurological involvement (neuroBehçet syndrome - NBS), 16 individuals with BD without neurological involvement and 18 healthy controls (HC). Overall we found a tendency for increased levels of anti-viral IgG antibody levels in BD, more evident in NBS patients versus HC. Epstein-Barr viral-capsid antigen IgG titres were increased in NBS patients versus other BD patients (p=0.032). Anti-measles antibody titres induced by vaccination were similarly elevated. ABGAs were not detected in the serum of our cohort. Raised levels of serum IL-8 in some BD patients did not reflect clinical activity or severity. In conclusion, there was evidence for a polyclonal immune activation rather than a specific virus effect in the sera of individuals with BD or NBS. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Response to the comment “Uranyl-chloride speciation and uranium transport in hydrothermal brines: Comment on Migdisov et al. (2018)” by Dargent et al.

    SciT

    Migdisov, A. A.; Runde, W.; Williams-Jones, A. E.

    We welcome the comments provided by Dargent et al. (2018) and appreciate the effort they have made to evaluate our recently reported data on the stability of uranyl(VI) chloride complexes as function of temperature (Migdisov et al., 2018). We also appreciate the opportunity provided by the editor to clarify issues in our paper that were not clearly articulated or in error.

  9. Managing Time, Workload and Costs in Distance Education: Findings from a Literature Review of "Distances et Médiations des Savoirs" (Formerly "Distances et Savoirs")

    ERIC Educational Resources Information Center

    Moeglin, Pierre; Vidal, Martine

    2015-01-01

    The purpose of this review, spanning over 12 years of publication of "Distances et Médiations des Savoirs" ("DMS"), formerly "Distance et Savoirs" ("DMS") (2003-2014), is guided by the question why and how French-speaking researchers addressed the issues of time, workload and costs in distance learning, and…

  10. "Francisco Maestas et al. v. George H. Shone et al.": Mexican American Resistance to School Segregation in the Hispano Homeland, 1912-1914

    ERIC Educational Resources Information Center

    Donato, Ruben; Guzmán, Gonzalo; Hanson, Jarrod

    2017-01-01

    The authors in this article argue that the "Francisco Maestas et al. vs. George H. Shone et al." (1914) case is one of the earliest Mexican American challenges to school segregation in the United States. Unidentified for over a century, the lawsuit took place in southern Colorado, a region of the nation where Mexican Americans have deep…

  11. Commentary: So Was It Worth It? a Commentary on Fricke Et Al. and Hagen Et Al. (2017)

    ERIC Educational Resources Information Center

    McCartney, Elspeth

    2017-01-01

    Fricke et al. and Hagen et al. (2017) each report on large-scale pragmatic randomised controlled trials delivered in schools or nurseries, investigating language interventions for vulnerable children and showing moderate positive effect sizes. Such research is part of a recent development of 'what works' research in England, and the number of…

  12. Actuarial risk assessment: commentary on Berlin et al.

    PubMed

    Hart, Stephen D

    2003-10-01

    F. S. Berlin, N. W. Galbreath, B. Geary, and G. McGlone (this issue) have raised some important questions regarding the use of acturial risk assessment instruments in sex offender civil commitment proceedings, also known as sexually violent predator or SVP proceedings. Their primary point is that interpreting the findings of existing actuarial risk assessment instruments is a tricky business because it is not certain whether the extent to which probability estimates derived from group data can be applied to individual cases. I agree completely with Berlin et al. on this point, but disagree with them concerning the extent to which probability estimates--and, therefore, actuarial instruments--are legally relevant in SVP proceedings. I outline some potential problems with respect to the legal admissibility of actuarial instruments, including their legal relevance.

  13. Cognitive Processes in Dissociation: Comment on Giesbrecht et al. (2008)

    PubMed Central

    Bremner, J. Douglas

    2010-01-01

    In “Cognitive Processes in Dissociation: An Analysis of Core Theoretical Assumptions,” published in Psychological Bulletin, Giesbrecht, Lynn, Lilienfeld, and Merckelbach (2008) have challenged the widely accepted trauma theory of dissociation, which holds that dissociative symptoms are caused by traumatic stress. In doing so the authors outline a series of links between various constructs, such as fantasy proneness, cognitive failures, absorption, suggestibility, altered information-processing, dissociation, and amnesia, claiming that these linkages lead to the false conclusion that trauma causes dissociation. A review of the literature, however, shows that these are not necessarily related constructs. Careful examination of their arguments reveals no basis for the conclusion that there is no association between trauma and dissociation. The current comment offers a critical review and rebuttal of the argument of Giesbrecht et al. that there is no relationship between trauma and dissociation. PMID:20063920

  14. Thermal design and TDM test of the ETS-VI

    NASA Astrophysics Data System (ADS)

    Yoshinaka, T.; Kanamori, K.; Takenaka, N.; Kawashima, J.; Ido, Y.; Kuriyama, Y.

    The Engineering Test Satellite-VI (ETS-VI) thermal design, thermal development model (TDM) test, and evaluation results are described. The allocation of the thermal control materials on the spacecraft is illustrated. The principal design approach is to minimize the interactions between the antenna tower module and the main body, and between the main body and the liquid apogee propulsion system by means of multilayer insulation blankets and low conductance graphite epoxy support structures. The TDM test shows that the thermal control subsystem is capable of maintaining the on-board components within specified temperature limits. The heat pipe network is confirmed to operate properly, and a uniform panel temperature distribution is accomplished. The thermal analytical model is experimentally verified. The validity of the thermal control subsystem design is confirmed by the modified on-orbit analytical model.

  15. Cognitive processes in dissociation: comment on Giesbrecht et al. (2008).

    PubMed

    Bremner, J Douglas

    2010-01-01

    In their recent review "Cognitive Processes in Dissociation: An Analysis of Core Theoretical Assumptions," published in Psychological Bulletin, Giesbrecht, Lynn, Lilienfeld, and Merckelbach have challenged the widely accepted trauma theory of dissociation, which holds that dissociative symptoms are caused by traumatic stress. In doing so, the authors have outlined a series of links between various constructs--such as fantasy proneness, cognitive failures, absorption, suggestibility, altered information-processing, dissociation, and amnesia--claiming that these linkages lead to the false conclusion that trauma causes dissociation. A review of the literature, however, shows that these are not necessarily related constructs. Careful examination of their arguments reveals no basis for the conclusion that there is no association between trauma and dissociation. The current comment offers a critical review and rebuttal of Giesbrecht et al.'s argument that there is no relationship between trauma and dissociation.

  16. Dopamine and reward: comment on Hernandez et al. (2006).

    PubMed

    Gallistel, C R

    2006-08-01

    Many lines of evidence suggest that the dopaminergic projection from the midbrain tegmentum to the forebrain must play a critical role in mediating the behavioral effects of natural and artificial rewards, with brain stimulation reward and addictive drugs included in the latter category. However, a closer look reveals many incongruities. The work of G. Hernandez et al. (2006) resolves several puzzles. It implies that the dopaminergic projection does not carry the signal that encodes the magnitude of a brain stimulation reward. It suggests that the elevation in the tonic levels of dopamine consequent on brain stimulation reward modulates the registration of the magnitude of the reward. This reconciles the psychophysical evidence with the pharmacological, electrophysiological, and anatomical evidence. However, some serious puzzles do remain.

  17. Recurrent aortic aneurysms in Behçet disease.

    PubMed

    Adams, Corey; Zhen-Yu Tong, Michael; Lawlor, D Kirk; DeRose, Guy; Forbes, Thomas L

    2010-01-01

    The following is a case of a 22-year-old male with recurrent thoracic aneurysms with several constitutional symptoms, including gastrointestinal discomfort, irritable bowel syndrome, lactose intolerance, and a 2-week history of severe lower back pain. The patient underwent an initial thoracoabdominal repair of a visceral aneurysm followed by endovascular repair of a recurrent thoracic pseudoaneurysm. The etiology of the visceral aneurysm was initially hypothesized to be mycotic; however, further information revealed signs and symptoms consistent with the diagnostic criteria for Behçet disease (BD). We suggest that BD be considered in younger patients who present with an aortic aneurysm. Although open repair is the traditional approach for arterial lesions in BD, the role for endovascular intervention should be considered as it represents a surgical repair with a significant reduction in morbidity.

  18. Spread spectrum mobile communication experiment using ETS-V satellite

    NASA Technical Reports Server (NTRS)

    Ikegami, Tetsushi; Suzuki, Ryutaro; Kadowaki, Naoto; Taira, Shinichi; Sato, Nobuyasu

    1990-01-01

    The spread spectrum technique is attractive for application to mobile satellite communications, because of its random access capability, immunity to inter-system interference, and robustness to overloading. A novel direct sequence spread spectrum communication equipment is developed for land mobile satellite applications. The equipment is developed based on a matched filter technique to improve the initial acquisition performance. The data rate is 2.4 kilobits per sec. and the PN clock rate is 2.4552 mega-Hz. This equipment also has a function of measuring the multipath delay profile of land mobile satellite channel, making use of a correlation property of a PN code. This paper gives an outline of the equipment and the field test results with ETS-V satellite.

  19. [Aortic inflammatory lesions in Behçet's disease].

    PubMed

    Desbois, A-C; Wechsler, B; Cacoub, P; Saadoun, D

    2016-04-01

    The arterial lesions affect about 10% of patients with Behçet's disease (BD). Aortic inflammatory involvement includes predominantly aortic aneurysmal lesions affecting most often the abdominal aorta. They account for the severity of the disease and are a leading cause of death when they hit the aorta or pulmonary arteries. Within the arterial lesions of BD, aortic involvement is, with femoral lesions, the most common site involved (18-28% of patients with vascular disease). Unlike other large vessels vasculitis (i.e. giant cell arteritis and Takayasu's arteritis) diffuse aortitis is observed in less than 5% of patients with BD. Aortic lesions of BD may be asymptomatic (systematic imaging or occasionally associated with other vascular event) or be revealed by the occurrence of abdominal, thoracic or lumbar pain, or an aortic valve insufficiency. Fever is frequently associated. Increase in acute phase reactants is common in these patients. Histological analysis may show infiltration by lymphocytes, neutrophils and plasma cells in the media and adventitia and a proliferation of the vasa vasorum in the media as well as a fibroblastic proliferation. In the later phase, a fibrous thickening of the media and adventitia is observed as well as a proliferation and thickening of the vasa vasorum. The therapeutic management should always include a medical treatment for the control of inflammation (corticosteroids, immunosuppressive drugs and/or biotherapy) and often an endovascular or surgical treatment if the aneurysm is threatening. The choice between endovascular or surgical treatment is considered case by case, depending on the experience of the team, anatomical conditions and of the clinical presentation. In this review, we provide a detailed and updated review of the literature to describe the aortic inflammatory damage associated with Behçet's disease. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights

  20. Canine treatment with SnET2 for photodynamic therapy

    NASA Astrophysics Data System (ADS)

    Frazier, Donita L.; Milligan, Andrew J.; Vo-Dinh, Tuan; Morgan, Alan R.; Overholt, Bergein F.

    1990-07-01

    Photodynamic therapy is a treatment technique that utilizes the photoactived species of a drug to destroy tumor tissue. To be successful, the drug must localize in tumor tissue preferentially over normal tissue and must be activated by light of a specific wavelength. Currently the only drug to be approved for clinical use is Heinatoporphyrin Derivative (HpD) although a series of new drugs are being developed for use in the near future. One of the drugs belongs to a class called purpurins which display absorp-' tions between 630-711 nm. Along with several other investigators, we are currently exploring the characteristics of a specific purpurin (SnET2) in normal and tumorous canine tissue. The use of this compound has demonstrated increased tumor control rates in spontaneous dog tumors. Preliminary pharmacokinetic studies have been performed on 6 normal beagle dogs. SnET2 (2 mg/kg) was injected intravenously over 10 minutes and blood was collected at 5, 15, 30, 45 minutes and at 1, 2, 4, 8, 12 and 24 hours following administration for determination of drug concentration and calculation of pharinacokinetic parameters. Skin biopsies were collected at 1, 4, 8, 12 and 24 hours. Dogs were euthanized at 24 hours and tissues (liver, kidney muscle, esophagus, stomach, duodenum, jejunum, ileura, colon, adrenal gland, thyroid, heart, lung, urinary bladder, prostate, pancreas, eye, brain) were collected for drug raeasurement. Drug was shown to persist in liver and kidney for a prolonged period of time coiapared to other tissues. Knowledge of the pharmacokinetic properties of the drug will greatly add to the ability to treat patients with effective protocols.

  1. Séroprévalence et facteurs associés au VIH et aux hépatites virales B et C dans la ville de Bafoussam au Cameroun

    PubMed Central

    Mbopi-Keou, Francois-Xavier; Nkala, Isabelle Vanessa Monthe; Kalla, Ginette Claude Mireille; Nguefack-Tsague, Georges; Kamga, Hortense Gonsu; Noubom, Michel; Mvogo, Côme Ebana; Sosso, Maurice Aurelien

    2015-01-01

    Introduction L'objectif de ce travail était de déterminer la séroprévalence et les facteurs associés au VIH et aux hépatites virales B et C dans la ville de Bafoussam au Cameroun. Méthodes Il s'agissait d'une étude descriptive et analytique réalisée de février 2012 à Juin 2012 dans la ville de Bafoussam au Cameroun. Pour cette étude, nous avons obtenu une clairance éthique. Résultats Au total, 982 personnes ont été dépistées pour le VIH et les hépatites virales B et C. Les femmes représentaient 56,3% des personnes dépistées. La tranche d’âge la plus représentée était celle des 20 à 24 ans. L’âge médian était de 34,5 ans. Les prévalences du VIH, de l'AgHBs, et de l'Ac anti HCV étaient respectivement de 6,0%, 4,1%, et 0,4%. La prévalence du VIH était 2 fois plus élevée parmi les femmes que les hommes avec 8,1% contre 3,5% (p=0,01). Les prévalences les plus élevées ont été observées chez les personnes de 30 à 34 ans, 40 à 44 ans avec 15,0% et 11,5% (p=0,01), les personnes sans emploi avec 11,1% (p<0,001) et les personnes en union libre avec 17,9% (p=0,000). La prévalence du VIH n’était pas directement liée aux comportements et pratiques sexuels de la population de l’étude. On enregistrait une prévalence élevée de 29,3% chez les individus ayant déclaré avoir au moins une infection sexuellement transmissible (p=0,000). Conclusion Il apparait urgent de mettre en place des stratégies de prévention contre le VIH, les hépatites virales et les facteurs associés au Cameroun. PMID:26113899

  2. Une vie saine et active : des directives en matière d’activité physique chez les enfants et les adolescents

    PubMed Central

    Lipnowski, Stan; LeBlanc, Claire MA

    2012-01-01

    RÉSUMÉ L’épidémie d’obésité juvénile augmente partout dans le monde. Même si les facteurs de risque d’obésité sont multifactoriels, bon nombre sont liés au mode de vie et se prêtent à une intervention. Ces facteurs incluent le comportement sédentaire et la thermogenèse sans activité physique, de même que la fréquence, l’intensité, la quantité et le type d’activité physique. Les dispensateurs de soins de première ligne sont en position idéale pour surveiller le taux d’activité physique des enfants, des adolescents et de leur famille, évaluer les choix liés au mode de vie et offrir des conseils pertinents. Le présent document de principes contient des directives visant à réduire le comportement sédentaire et à accroître le taux d’activité physique au sein de la population pédiatrique. Des recommandations d’activités physiques adaptées au développement et visant les nourrissons, les tout-petits, les enfants d’âge préscolaire, les enfants et les adolescents sont présentées. Des stratégies de promotion d’une vie saine et active sur les scènes locale, municipale, provinciale, territoriale et fédérale sont proposées.

  3. Derived Optimal Linear Combination Evapotranspiration (DOLCE): a global gridded synthesis ET estimate

    NASA Astrophysics Data System (ADS)

    Hobeichi, Sanaa; Abramowitz, Gab; Evans, Jason; Ukkola, Anna

    2018-02-01

    Accurate global gridded estimates of evapotranspiration (ET) are key to understanding water and energy budgets, in addition to being required for model evaluation. Several gridded ET products have already been developed which differ in their data requirements, the approaches used to derive them and their estimates, yet it is not clear which provides the most reliable estimates. This paper presents a new global ET dataset and associated uncertainty with monthly temporal resolution for 2000-2009. Six existing gridded ET products are combined using a weighting approach trained by observational datasets from 159 FLUXNET sites. The weighting method is based on a technique that provides an analytically optimal linear combination of ET products compared to site data and accounts for both the performance differences and error covariance between the participating ET products. We examine the performance of the weighting approach in several in-sample and out-of-sample tests that confirm that point-based estimates of flux towers provide information on the grid scale of these products. We also provide evidence that the weighted product performs better than its six constituent ET product members in four common metrics. Uncertainty in the ET estimate is derived by rescaling the spread of participating ET products so that their spread reflects the ability of the weighted mean estimate to match flux tower data. While issues in observational data and any common biases in participating ET datasets are limitations to the success of this approach, future datasets can easily be incorporated and enhance the derived product.

  4. Identification of an interaction between calcium-dependent protein kinase 4 (EtCDPK4) and serine protease inhibitor (EtSerpin) in Eimeria tenella.

    PubMed

    Lv, Ling; Huang, Bing; Zhao, Qiping; Zhao, Zongping; Dong, Hui; Zhu, Shunhai; Chen, Ting; Yan, Ming; Han, Hongyu

    2018-04-23

    Eimeria tenella is an obligate intracellular apicomplexan protozoan parasite that has a complex life-cycle. Calcium ions, through various calcium-dependent protein kinases (CDPKs), regulate key events in parasite growth and development, including protein secretion, movement, differentiation, and invasion of and escape from host cells. In this study, we identified proteins that interact with EtCDPK4 to lay a foundation for clarifying the role of CDPKs in calcium channels. Eimeria tenella merozoites were collected to construct a yeast two-hybrid (Y2H) cDNA library. The Y2H system was used to identify proteins that interact with EtCDPK4. One of interacting proteins was confirmed using bimolecular fluorescence complementation and co-immunoprecipitation in vivo. Co-localization of proteins was performed using immunofluorescence assays. Eight proteins that interact with EtCDPK4 were identified using the Y2H system. One of the proteins, E. tenella serine protease inhibitor 1 (EtSerpin), was further confirmed. In this study, we screened for proteins that interact with EtCDPK4. An interaction between EtSerpin and EtCDPK4 was identified that may contribute to the invasion and development of E. tenella in host cells.

  5. A meta-analysis of neuropsychological outcome after mild traumatic brain injury: re-analyses and reconsiderations of Binder et al. (1997), Frencham et al. (2005), and Pertab et al. (2009).

    PubMed

    Rohling, Martin L; Binder, Laurence M; Demakis, George J; Larrabee, Glenn J; Ploetz, Danielle M; Langhinrichsen-Rohling, Jennifer

    2011-05-01

    The meta-analytic findings of Binder et al. (1997) and Frencham et al. (2005) showed that the neuropsychological effect of mild traumatic brain injury (mTBI) was negligible in adults by 3 months post injury. Pertab et al. (2009) reported that verbal paired associates, coding tasks, and digit span yielded significant differences between mTBI and control groups. We re-analyzed data from the 25 studies used in the prior meta-analyses, correcting statistical and methodological limitations of previous efforts, and analyzed the chronicity data by discrete epochs. Three months post injury the effect size of -0.07 was not statistically different from zero and similar to that which has been found in several other meta-analyses (Belanger et al., 2005; Schretlen & Shapiro, 2003). The effect size 7 days post injury was -0.39. The effect of mTBI immediately post injury was largest on Verbal and Visual Memory domains. However, 3 months post injury all domains improved to show non-significant effect sizes. These findings indicate that mTBI has an initial small effect on neuropsychological functioning that dissipates quickly. The evidence of recovery in the present meta-analysis is consistent with previous conclusions of both Binder et al. and Frencham et al. Our findings may not apply to people with a history of multiple concussions or complicated mTBIs.

  6. Response to Julian et al. (2015) "comment on and reinterpretation of Gabriel et al. (2014) 'fish mercury and surface water sulfate relationships in the everglades protection area'".

    PubMed

    Gabriel, Mark C; Axelrad, Don; Orem, William; Osborne, Todd Z

    2015-06-01

    The purpose of this forum is to respond to a rebuttal submitted by Julian et al., Environ Manag 55:1-5, 2015 where they outlined their overall disagreement with the data preparation, methods, and interpretation of results presented in Gabriel et al. (Environ Manag 53:583-593, 2014). Here, we provide background information on the research premise presented in Gabriel et al. (Environ Manag 53:583-593, 2014) and provide a defense for this work using five themes. In spite of what Julian et al. perceive as limitations in the sampling methods and analytical tools used for this work, the relationships found between fish total mercury and surface water sulfate concentrations in Gabriel et al. (Environ Manag 53:583-593, 2014) are comparable to relationships between pore water methylmercury (MeHg) and pore water sulfate found in past studies indicating that sulfate is important to MeHg production and bioaccumulation in the Everglades. Julian et al. state "…there is no way to justify any ecosystem-wide sulfur strategy as a management approach to reduce mercury risk in the (Everglades) as suggested by Gabriel et al. (Environ Manag 53:583-593, 2014), Corrales et al. (Sci Tot Environ 409:2156-2162, 2011) and Orem et al. (Rev Environ Sci Technol 41 (S1):249-288, 2011)." We disagree, and having stated why sulfate input reduction to the Everglades may be the most effective means of reducing mercury in Everglades fish, it is important that research on sulfur and mercury biogeochemistry continues. If further studies support the relationship between sulfate loading reduction and MeHg reduction, sulfur mass balance studies should commence to (1) better quantify agricultural and connate seawater sulfate inputs and (2) define opportunities to reduce sulfate inputs to the Everglades ecosystem.

  7. Ecoulement et mise en structure de suspensions macroscopiques

    NASA Astrophysics Data System (ADS)

    Petit, L.

    In this review, we report the various experimental studies performed on suspensions of solid particules in liquids, and concerning the rheological behaviour of such systems and the ordering of particules under the applied velocity fields. The number of materials which are flowing suspensions (reagents in chemical engineering, paints while spreading, blood flow, muds in oil reservoir) gave rise to a number of experimental studies, especially in the last twenty years. The results show a wide variety of behaviour, even for systems of intermediate concentration. In addition, even for identical systems, the results depend of the type of flow. Then, it is clear that, in addition of the standard parameters which are to be taken into account, it is necessary to consider the type of flow the suspension is submitted to. The flow influences the spatial distribution of the particules, leading to their ordering or migration. These ordering or motions influence the flow, and then, the rheological behaviour of the whole system. So, there is a feedback mechanism from the ordering to the flow, which explains the experimental observations. Nous reportons dans cette revue les différentes études expérimentales réalisées sur les suspensions de particules solides dans un liquide et qui concernent le comportement rhéologique de ces systèmes ainsi que les mouvements des particules sous l'effet des champs de vitesse imposés. Ces mouvements peuvent conduire soit à des mises en structure, ou encore à des migrations des particules. L'importance du nombre de matériaux qui se présentent sous forme de suspension et qui sont mis en écoulement (réactif en génie chimique, peintures lors de leur mise en place, écoulement sanguin, boues dans les forages pétroliers,...) a motivé un grand nombre de travaux expérimentaux plus fondamentaux sur le sujet, particulièrement dans les vingt dernières années. Les résultats correspondants montrent une très grande diversité des

  8. Le recours aux modeles dans l'enseignement de la biologie au secondaire : Conceptions d'enseignantes et d'enseignants et modes d'utilisation

    NASA Astrophysics Data System (ADS)

    Varlet, Madeleine

    Le recours aux modeles et a la modelisation est mentionne dans la documentation scientifique comme un moyen de favoriser la mise en oeuvre de pratiques d'enseignement-apprentissage constructivistes pour pallier les difficultes d'apprentissage en sciences. L'etude prealable du rapport des enseignantes et des enseignants aux modeles et a la modelisation est alors pertinente pour comprendre leurs pratiques d'enseignement et identifier des elements dont la prise en compte dans les formations initiale et disciplinaire peut contribuer au developpement d'un enseignement constructiviste des sciences. Plusieurs recherches ont porte sur ces conceptions sans faire de distinction selon les matieres enseignees, telles la physique, la chimie ou la biologie, alors que les modeles ne sont pas forcement utilises ou compris de la meme maniere dans ces differentes disciplines. Notre recherche s'est interessee aux conceptions d'enseignantes et d'enseignants de biologie au secondaire au sujet des modeles scientifiques, de quelques formes de representations de ces modeles ainsi que de leurs modes d'utilisation en classe. Les resultats, que nous avons obtenus au moyen d'une serie d'entrevues semi-dirigees, indiquent que globalement leurs conceptions au sujet des modeles sont compatibles avec celle scientifiquement admise, mais varient quant aux formes de representations des modeles. L'examen de ces conceptions temoigne d'une connaissance limitee des modeles et variable selon la matiere enseignee. Le niveau d'etudes, la formation prealable, l'experience en enseignement et un possible cloisonnement des matieres pourraient expliquer les differentes conceptions identifiees. En outre, des difficultes temporelles, conceptuelles et techniques peuvent freiner leurs tentatives de modelisation avec les eleves. Toutefois, nos resultats accreditent l'hypothese que les conceptions des enseignantes et des enseignants eux-memes au sujet des modeles, de leurs formes de representation et de leur approche

  9. L'evolution du littoral meridional de la vendee (France) d'apres des donnees LANDSAT 1, 2 et 3 et SEASAT

    NASA Astrophysics Data System (ADS)

    Cuq, F.; Hilton, R.; Lummaux, L. C.; Verger, F.

    Les données des satellites LANDSAT et SEASAT fondent une étude précise des milieux intertidaux ainsi que de la cinématique de la dune et de la plage. Les données SEASAT permettent, grâce à une analyse harmonique de l'image, de cartographier les trains de houles obliques à la côte et donc de percevoir le sens de la dérive des sédiments.

  10. Crise convulsive chez les abuseurs de Tramadol et caféine: à propos de 8 cas et revue de la littérature

    PubMed Central

    Maiga, Djibo Douma; Seyni, Houdou; Sidikou, Amadou; Azouma, Alfazazi

    2012-01-01

    Nous rapportons Huit cas de crises convulsives diagnostiquées comme maladie épileptique après ingestion de Tramadol et d'autres substances psychotropes dont la Caféine dans une région ou maladie épileptique et addiction au café sont fréquentes. L'objectif de ce travail était d'informer les praticiens sur le risque de convulsion lié à la consommation du Tramadol seul ou en association avec d'autres psychotropes en s'appuyant sur les données de la littérature. Il s'agissait d'une étude rétrospective et exhaustive de patients vus en consultation ambulatoire pour crise convulsive et consommation de Tramadol et de caféine de janvier à mai 2012. Les données collectées étaient les caractéristiques sociodémographiques et de la consommation de Tramadol. Le diagnostic de crise convulsive a été posé sur les renseignements obtenus à l'anamnèse. Tous les patients ont été soumis à un examen neurologique et aux critères de dépendance du Diagnostic and Statistical Manual of Mental Disorders (DSMIV)-R par rapport à leur consommation de Tramadol. Nous n'avons pas trouvé dans la littérature médicale de cas de consommation concomitante de Tramadol et de Caféine. Les données expérimentales suggèrent une action synergique du Tramadol et de la Caféine sur la douleur et le seuil épileptogène. Nos observations plaident également en faveur d'une synergie d'action de ces deux molécules dans la survenue des crises convulsives. La fréquence des crises convulsives suite à une intoxication par le Tramadol et la caféine est susceptible d'augmenter en Afrique en raison du mésusage croissant de ces substances. Une étude comparative usagers de Tramadol associé à la Caféine et usagers du Tramadol seul devrait permettre d’évaluer le risque. PMID:23308329

  11. [TURP plus endocrine therapy (ET) versus α1A-blockers plus ET for bladder outlet obstruction in advanced prostate cancer].

    PubMed

    Tao, Ling-song; Tao, Liang-jun; Chen, Yi-sheng; Zou, Bin; Zhu, Guang-biao; Wang, Jia-wei; Liang, Chao-zhao

    2015-07-01

    To compare the effect of transurethral resection of the prostate combined with endocrine therapy (TURP + ET) with that of αlA-blockers combined with ET ((αlA-b + ET) in the treatment of bladder outlet obstruction (BOO) in patients with advanced prostate cancer (PCa), and to investigate the safety of the TURP + ET for the treatment of PCa with BOO. We retrospectively analyzed 63 cases of PCa with BOO, 28 treated by αlA-b + ET and the other 35 by TURP + ET. We obtained the residual urine volume (RV), maximum urinary flow rate (Qmax), International Prostate Symptom Score (IPSS), and quality of life score (QoL) before and after treatment along with the overall survival rate of the patients, followed by comparison of the parameters between the two methods. At 3 months after treatment, RV, IPSS, and QoL in the TURP + ET group were significantly decreased from (137.8 ± 27.6) ml, (22.3 ± 3.6), and (4.2 ± 0.8) to (29 ± 13.6) ml, (7.8 ± 2.1), and (1.6 ± 0.5) respectively (P < 0.05), while Qmax increased from (5.6 ± 2.1) ml/s to (17.6 ± 2.7) ml/s (P < 0.05); the former three parameters in the αlA-b + ET group decreased from (133.6 ± 24.9) ml, (21.5 ± 3.2), and (4.7 ± 1.1) to (42 ± 18.3) ml, (12.8 ± 2.6), and (2.5 ± 0.7) respectively (P < 0.05), while the latter one increased from (6.3 ± 2.4) ml/s to (11.7 ± 2.3) ml/s (P < 0.05), all with statistically significant differences between the two groups (P < 0.05). The overall survival rate of the TURP + ET group was not significantly different from that of the αlA-b + ET group (51.4% vs 46.4% , P > 0.05). TURP + ET is preferable to αlA-b + ET for its advantage of relieving BOO symptoms in advanced PCa without affecting the overall survival rate of the patients.

  12. Astéroides et satellites de Saturne: quelques résultats récents et contribution éventuelle des données Hipparcos.

    NASA Astrophysics Data System (ADS)

    Viateau, B.; Rapaport, M.

    48 astéroides et 2 satellites de Saturne étaient au programme de la mission Hipparcos, et diverses propositions ont été faites pour l'utilisation de ces données. Les auteurs présentent quelques résultats récents concernant ces objets, et susceptibles de 1) donner un supplément d'intére^t aux données astrométriques fournies par Hipparcos, 2) permettre de préciser les objectifs contenus dans diverses propositions.

  13. Mesures experimentales de l'impact des revetements hydrophobeset superhydrophobes sur la trainee et la portance d'un profil aerodynamique propre et glace

    NASA Astrophysics Data System (ADS)

    Villeneuve, Eric

    Ce projet, realise a la demande du Laboratoire International des Materiaux Antigivre, a pour but de mesurer et definir experimentalement l'impact de revetements hydrophobes sur les coefficients de trainee et de portance d'un profil NACA 0012. Pour ce faire, la balance aerodynamique du LIMA devait tout d'abord etre amelioree afin d'offrir une sensibilite suffisante pour realiser le projet. Plusieurs ameliorations ont ete faites, comme le changement des cellules de charge, la diminution du nombre de cellules de charge, le changement du cadre de la balance, etc. Une fois ces ameliorations terminees, la reproductibilite, l'exactitude et la sensibilite ont ete valides afin de s'assurer de la fiabilite des resultats offerts par la balance. Pour les angles d'attaque etudies avec les revetements, soient -6° et 0°, la balance a une reproductibilite de +/-2,06% a 360 000 de nombre de Reynolds. Pour valider la sensibilite, des essais a -6° et 0° d'angle d'attaque et des nombres de Reynolds de 360 000 et 500 000 ont ete faits avec des papiers sables. Les resultats de ces essais ont permis de, tracer des courbes de tendances du coefficient de trainee du NACA 0012 en fonction de la rugosite de surface et d'etablir la valeur de la sensibilite de la balance a +/-8 mu m. Cinq revetements populaires ont ete choisis pour l'experimentation, soient le Wearlon, le Staclean, le Hirec, le Phasebreak ainsi que le Nusil. Les revetements sont soumis aux memes conditions experimentales que les papiers sables, et une rugosite equivalente est trouvee par extrapolation des resultats. Cependant, les rugosites equivalentes de surfaces different entre -6° et 0°. Les essais avec le Staclean et le Hirec donnent des coefficients de trainee equivalent a ceux avec l'aluminium, alors que le Wearlon, le Nusil et le Phasebreak donnent une augmentation du coefficient de trainee de 13%, 17% et 25% respectivement par rapport a l'aluminium. Pour les coefficients de portance, la balance ne detecte pas l

  14. FBI-1 enhances ETS-1 signaling activity and promotes proliferation of human colorectal carcinoma cells.

    PubMed

    Zhu, Min; Li, Mingyang; Zhang, Fan; Feng, Fan; Chen, Weihao; Yang, Yutao; Cui, Jiajun; Zhang, Dong; Linghu, Enqiang

    2014-01-01

    In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity of ETS-1. The protein interaction was identified between ETS-1 and FBI-1 in lovo cells. The accumulating data showed that FBI-1 promoted the recruitment of ETS-1 to endogenous promoter of its target genes and increase ETS-1 accumulation in the nuclear. Our work also indicated that the FBI-1 enhances ETS-1 transcription factor activity via down-regulating p53-mediated inhibition on ETS-1. Further, FBI-1 plays a role in regulation of colorectal carcinoma cells proliferation. These findings supported that FBI-1 might be a potential molecule target for treating colorectal carcinoma.

  15. FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells

    PubMed Central

    Chen, Weihao; Yang, Yutao; Cui, Jiajun; Zhang, Dong; Linghu, Enqiang

    2014-01-01

    In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity of ETS-1. The protein interaction was identified between ETS-1 and FBI-1 in lovo cells. The accumulating data showed that FBI-1 promoted the recruitment of ETS-1 to endogenous promoter of its target genes and increase ETS-1 accumulation in the nuclear. Our work also indicated that the FBI-1 enhances ETS-1 transcription factor activity via down-regulating p53-mediated inhibition on ETS-1. Further, FBI-1 plays a role in regulation of colorectal carcinoma cells proliferation. These findings supported that FBI-1 might be a potential molecule target for treating colorectal carcinoma. PMID:24857950

  16. [Ocular manifestations of Behçet's disease].

    PubMed

    Saadoun, D; Cassoux, N; Wechsler, B; Boutin, D; Terrada, C; Lehoang, P; Bodaghi, B; Cacoub, P

    2010-08-01

    Eye involvement in Behçet's disease (BD) is frequent and an important cause of morbidity. The mean age at onset of uveitis is between 20 and 30 years in male and 30 years in female patients. Ocular involvement includes anterior, posterior or panuveitis. Uveitis may be the presenting manifestation of the disease in 20% of cases or may appear 2 or 3 years after the disease onset. The estimated risk of blindness at 5 years ranges from 15 to 25%. The main goals in the management of patients with BD uveitis are the rapid control of intraocular inflammation, the prevention of recurrent attacks, the achievement of complete remission, and preservation of vision. The medical treatment of patients with severe uveitis relies on the use of systemically administered drugs, including corticosteroids and cytotoxic agents. Anti-TNF agents and interferon-alpha seem to be efficient and well-tolerated alternative therapeutic options. Controlled clinical trials are mandatory to define the place of these new immunomodulatory agents in the therapeutic strategy, and especially their use as first-line therapy. Copyright (c) 2010 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

  17. Behçet syndrome: the vascular cluster.

    PubMed

    Yazıcı, Hasan; Seyahi, Emire

    2016-11-17

    Although skin-mucosa lesions are common in almost all patients with Behçet syndrome (BS), clinical properties may differ from one patient to another. Within BS, there are subsets with different organ involvement and hence probably different pathological pathways. These subsets can be described as a) solo skin-mucosa disease with no major organ involvement, b) eye disease, c) seronegative spondyloarthropathy-like disease (arthritis, enthesopathy, and folliculitis), d) Crohn-like disease, and finally the topic of this chapter: e) vascular disease. In the vascular disease subset, not surprisingly, several types of vascular involvement may be observed in the same individual. These subsets may make up the total clinical picture all at the same time or step by step with each relapse. Significant correlations exist between cerebral vascular thrombosis and pulmonary artery involvement, intracardiac thrombi and pulmonary artery involvement, Budd-Chiari syndrome, and inferior vena cava syndrome. Lower extremity vein thrombosis is often present in these associations and even precedes them. The recognition of these clusters is not only important in diagnosis and management but also in basic science, including genetic studies.

  18. Behçet syndrome: is it one condition?

    PubMed

    Yazici, H; Ugurlu, S; Seyahi, E

    2012-12-01

    Behçet's syndrome (BS) is a disease of unknown etiology, and as such, there have been efforts to classify BS within the popular nosological identities of the times such as seronegative spondarthritides, autoimmune, and more recently autoinflammatory diseases. Current evidence suggests that BS does not easily fit into any one of these lumps, while on occasion, it might be impossible to tell BS from Crohn's disease, especially when the main clinical presentation is intestinal ulceration. There are distinct regional differences in disease expression of BS with fewer cases of intestinal disease in the Mediterranean basin and less severe eye disease and less frequent skin pathergy among patients reported from northern Europe or America. The clustering of symptoms, especially with the recently described increased frequency of the acne/arthritis cluster in familial cases, suggests that more than one pathological pathway is involved in what we call BS today. Supportive evidence for this contention also comes from the observations that (a) the genetic component is very complex with perhaps different genetic modes of inheritance in the adult and in the pediatric patients; and (b) there are differing organ responses to one same drug. For example, the anti-TNF agents successfully control the oral ulcers while they have no effect on the pathergy reaction.

  19. New therapeutic solutions for Behçet's syndrome.

    PubMed

    Vitale, Antonio; Rigante, Donato; Lopalco, Giuseppe; Emmi, Giacomo; Bianco, Maria Teresa; Galeazzi, Mauro; Iannone, Florenzo; Cantarini, Luca

    2016-07-01

    Behçet's syndrome (BS) is a systemic inflammatory disorder characterized by a wide range of potential clinical manifestations with no gold-standard therapy. However, the recent classification of BS at a crossroads between autoimmune and autoinflammatory syndromes has paved the way to new further therapeutic opportunities in addition to anti-tumor necrosis factor agents. This review provides a digest of all current experience and evidence about pharmacological agents recently described as having a role in the treatment of BS, including interleukin (IL)-1 inhibitors, tocilizumab, rituximab, alemtuzumab, ustekinumab, interferon-alpha-2a, and apremilast. IL-1 inhibitors currently represent the most studied agents among the latest treatment options for BS, proving to be effective, safe and with an acceptable retention on treatment. However, since BS is a peculiar disorder with clinical features responding to certain treatments that in turn can worsen other manifestations, identifying new treatment options for patients unresponsive to the current drug armamentarium is of great relevance. A number of agents have been studied in the last decade showing changing fortunes in some cases and promising results in others. The latter will potentially provide their contribution for better clinical management of BS, improving patients' quality of life and long-term outcome.

  20. Modeling the capillary discharge of an electrothermal (ET) launcher

    NASA Astrophysics Data System (ADS)

    Least, Travis

    Over the past few decades, different branches of the US Department of Defense (DoD) have invested at improving the field ability of electromagnetic launchers. One such focus has been on achieving hypervelocity launch velocities in excess of 7 km/s for direct launch to space applications [1]. It has been shown that pre-injection is required for this to be achieved. One method of pre-injection which has promise involves using an electro-thermal (ET) due to its ability to achieve the desired velocities with a minimal amount of hot plasma injected into the launcher behind the projectile. Despite the demonstration of pre-injection using this method, polymer ablation is not very well known and this makes it challenging to predict how the system will behave for a given input of electrical power. In this work, the rate of ablation has been studied and predicted using different models to generate the best possible characteristic curve. [1] - Wetz, David A., Francis Stefani, Jerald V. Parker, and Ian R. McNab. "Advancements in the Development of a Plasma-Driven Electromagnetic Launcher." IEEE TRANSACTIONS ON MAGNETICS 45.1 (2009): 495--500. IEEE Xplore. Web. 18 Aug. 2012.

  1. Lymphocyte ceruloplasmin and Behçet's disease.

    PubMed

    Oliveira, Rita; Banha, João; Martins, Fátima; Paixão, Eleonora; Pereira, Dina; Barcelos, Filipe; Teixeira, Ana; Patto, José Vaz; Costa, Luciana

    2006-01-01

    Behçet's disease (BD) is a rare chronic inflammatory disorder of unknown aetiology. However, it has been postulated that a dysregulation of the prooxidant/antioxidant balance may be important to its pathogenesis. Ceruloplasmin (CP) is an acute phase protein expressed at the surface of peripheral blood lymphocytes (PBL) with antioxidant properties and with a relevant role in iron (Fe) metabolism. To study CP expression at the surface of PBL (PBLCP) in patients with BD. We measured serum CP and PBLCP obtained from BD patients (n=10) and respective controls (n=10) using nephelometry and flow cytometry techniques, respectively. Additionally, haematological parameters, biochemical Fe metabolism markers [serum Fe, serum ferritin, serum transferrin, total Fe binding capacity (TIBC), transferrin saturation] and non-specific markers of inflammation [serum C reactive protein (CRP), beta2-microglobulin] were measured in all individuals. Despite the absence of significant differences between the two study groups when comparing serum CP, a significant difference in PBLCP was found in BD patients mainly due to a significant decrease of CP expression at the surface of CD3-CD56+ lymphocytes. Also, a significant decrease of PBLCP was observed in patients treated with azathioprine compared to patients that were not being treated with this drug. According to this study, we suggest that the significant decrease of PBLCP observed in BD patients might be due to azathioprine treatment and not directly related to the pathophysiology of BD.

  2. TAP polymorphism in patients with Behçet's disease.

    PubMed Central

    González-Escribano, M F; Morales, J; García-Lozano, J R; Castillo, M J; Sánchez-Román, J; Núñez-Roldán, A; Sánchez, B

    1995-01-01

    OBJECTIVE--To determine if susceptibility to Behçet's disease (BD) is associated with polymorphism of HLA-DRB1, HLA-DQB1, DQB1, and TAP1 and TAP2 genes. METHODS--Fifty eight Spanish BD patients and 116 ethnically matched unrelated healthy subjects were typed at the HLA-DRB1 and HLA-DQB1 loci using polymerase chain reaction/sequence specific oligotyping (PCR/SSO). TAP1 and TAP2 alleles were assigned using amplification refractory mutation system-PCR. RESULTS--TAP1C was absent in BD patients, but was found in 12.1% of control subjects (pcorr < 0.05; relative risk = 0.06). Additionally, a linkage disequilibrium between HLA-DQB1*0501 and TAP2B was observed in BD patients (delta = 0.095, pcorr < 0.02), but not in the control group (delta = -0.0031, p > 0.05). CONCLUSIONS--The complete absence of TAP1C alleles in BD patients may indicate that TAP1 polymorphism is not without some significance in the development of BD. Furthermore, the existence of a linkage disequilibrium between HLA-DQB1*0501 and TAP2B in our patients suggests that the gene conferring susceptibility for BD is inherited as an extended haplotype in the population studied. PMID:7794046

  3. Mean platelet volume in ocular Behçet's disease.

    PubMed

    Türkcü, Fatih Mehmet; Cingü, Abdullah Kürşat; Yüksel, Harun; Cınar, Yasin; Akkurt, Meltem; Sahin, Muhammed; Ozkurt, Zeynep; Sahin, Alparslan; Caça, Ihsan

    2013-01-01

    To determine whether mean platelet volume (MPV) is an indicator of disease severity in ocular Behçet's Disease (BD). The study population was 30 newly diagnosed ocular BD patients who presented with active uveitis. These patients had no past history of smoking, drug use, or systemic diseases including diabetes mellitus, hypertension, cardiovascular disease, and renal disease. A control group consisting of 34 healthy individuals was included for comparison. MPV measurements were performed serially upon presentation with active uveitis and at one and three month thereafter in BD group whereas only at presentation in the controls. Upon presentation with active uveitis, the mean MPV levels were 7.88 ± 1.14 femtoliters (fL) for BD group. During the posttreatment follow-up period at first and third months, BD patients demonstrated a mean MPV level of 7.71 ± 1.12 fL and 7.65 ± 1.04 fL, respectively. The mean MPV value of control group, was 8.39 ± 0.66 fL at presentation. Fluctuations in MPV values were not significant in the BD group, while there was a significant difference between the initial measurements of the BD and control groups. MPV measurement in ocular BD is not a predictive laboratory test to determine the clinical improvement in early stages following classical immunosuppressive treatment.

  4. Mean Platelet Volume in Ocular Behçet's Disease

    PubMed Central

    Türkcü, Fatih Mehmet; Cingü, Abdullah Kürşat; Yüksel, Harun; Çınar, Yasin; Akkurt, Meltem; Şahin, Muhammed; Özkurt, Zeynep; Şahin, Alparslan; Çaça, İhsan

    2013-01-01

    Objective. To determine whether mean platelet volume (MPV) is an indicator of disease severity in ocular Behçet's Disease (BD). Materials and Methods. The study population was 30 newly diagnosed ocular BD patients who presented with active uveitis. These patients had no past history of smoking, drug use, or systemic diseases including diabetes mellitus, hypertension, cardiovascular disease, and renal disease. A control group consisting of 34 healthy individuals was included for comparison. MPV measurements were performed serially upon presentation with active uveitis and at one and three month thereafter in BD group whereas only at presentation in the controls. Results. Upon presentation with active uveitis, the mean MPV levels were 7.88 ± 1.14 femtoliters (fL) for BD group. During the posttreatment follow-up period at first and third months, BD patients demonstrated a mean MPV level of 7.71 ± 1.12 fL and 7.65 ± 1.04 fL, respectively. The mean MPV value of control group, was 8.39 ± 0.66 fL at presentation. Fluctuations in MPV values were not significant in the BD group, while there was a significant difference between the initial measurements of the BD and control groups. Conclusion. MPV measurement in ocular BD is not a predictive laboratory test to determine the clinical improvement in early stages following classical immunosuppressive treatment. PMID:24250258

  5. STS-133/ET-137 Tanking Test Photogrammetry Assessment

    NASA Technical Reports Server (NTRS)

    Oliver, Stanley T.

    2012-01-01

    Following the launch scrub of Space Shuttle mission STS-133 on November 5, 2010, an anomalous condition of cracked and raised thermal protection system (TPS) foam was observed on the External Tank (ET). Subsequent dissection of the affected TPS region revealed cracks in the feet of two Intertank (IT) metallic stringers. An extensive investigation into the cause(s) and corrective action(s) for the cracked stringers was initiated, involving a wide array of material and structural tests and nondestructive evaluations, with the intent to culminate into the development of flight rational. One such structural test was the instrumented tanking test performed on December 17, 2010. The tanking test incorporated two three-dimensional optical displacement measurement systems to measure full-field outer surface displacements of the TPS surrounding the affected region that contained the stringer cracks. The results showed that the radial displacement and rotation of the liquid oxygen (LO2) tank flange changed significantly as the fluid level of the LO2 approached and passed the LO2 tank flange.

  6. Inner ear involvement in Behçet's disease.

    PubMed

    Süslü, Ahmet Emre; Polat, Mualla; Köybaşi, Serap; Biçer, Yusuf Ozgür; Funda, Yasemin Ongun; Parlak, Ali Haydar

    2010-06-01

    To assess cochlear involvement and hearing loss in patients with Behçet's disease (BD). Forty-two patients with BD and 24 sex and age matched healthy subjects were included in the study. pure-tone audiometry including high frequencies (250-16000Hz) and DPOAE were performed to all participants. Results of the audiological evaluation were compared and correlation between the audiologic status and clinical manifestations of the BD were investigated. Bilateral sensorineural hearing loss was detected in 27 (64.3%) patients. Hearing thresholds were found to be higher in patients with BD at all of the frequencies except at 500Hz when compared to control group (p<0.05). The difference in the hearing levels tend to increase in high frequencies. Compared with control group, distortion products and SNR of the BD patients were lower in all of the tested frequencies (p<0.05) which indicates weaker outer hair cell motility. There was no correlation between the clinical manifestations and the audiological parameters. Even having hearing levels within normal limits in speech frequencies, increased hearing thresholds in high frequencies and decreased signal-noise ratios (SNR) in distortion product otoacoustic emission (DPOAE) indicate a cochlear involvement in patients with BD. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.

  7. Collider Signal II:. Missing ET Signatures and Dark Matter Connection

    NASA Astrophysics Data System (ADS)

    Baer, Howard

    2010-08-01

    These lectures give an overview of aspects of missing ET signatures from new physics at the LHC, along with their important connection to dark matter physics. Mostly, I will concentrate on supersymmetric (SUSY) sources of ɆT, but will also mention Little Higgs models with T-parity (LHT) and universal extra dimensions (UED) models with KK-parity. Lecture 1 covers SUSY basics, model building and spectra computation. Lecture 2 addresses sparticle production and decay mechanisms at hadron colliders and event generation. Lecture 3 covers SUSY signatures at LHC, along with LHT and UED signatures for comparison. In Lecture 4, I address the dark matter connection, and how direct and indirect dark matter searches, along with LHC collider searches, may allow us to both discover and characterize dark matter in the next several years. Finally, the interesting scenario of Yukawa-unified SUSY is examined; this case works best if the dark matter turns out to be a mixture of axion/axino states, rather than neutralinos.

  8. External Tank (ET) Foam Thermal/Structural Analysis Project

    NASA Technical Reports Server (NTRS)

    Moore, David F.; Ungar, Eugene K.; Chang, Li C.; Malroy, Eric T.; Stephan, Ryan A.

    2008-01-01

    An independent study was performed to assess the pre-launch thermally induced stresses in the Space Shuttle External Tank Bipod closeout and Ice/Frost ramps (IFRs). Finite element models with various levels of detail were built that included the three types of foam (BX-265, NCFI 24-124, and PDL 1034) and the underlying structure and bracketry. Temperature profiles generated by the thermal analyses were input to the structural models to calculate the stress levels. An area of high stress in the Bipod closeout was found along the aluminum tank wall near the phenolic insulator and along the phenolic insulator itself. This area of high stress might be prone to cracking and possible delamination. There is a small region of slightly increased stress in the NCFI 24-124 foam near its joint with the Bipod closeout BX-265 foam. The calculated stresses in the NCFI 24-124 acreage foam are highest at the NCFI 24-124/PDL 1034/tank wall interface under the LO2 and LH2 IFRs. The highest calculated stresses in the LH2 NCFI 24-124 foam are higher than in similar locations in the LO2 IFR. This finding is consistent with the dissection results of IFRs on ET-120.

  9. Spectroscopie et fonctionnement laser de CaF{2}: Yb3+

    NASA Astrophysics Data System (ADS)

    Camy, P.; Doualan, J. L.; Petit, V.; Renard, S.; Thuau, M.; Moncorgé, R.

    2004-11-01

    CaF{2 }:Yb3+ est un cristal doté de propriétés optiques et thermiques qui en font un matériau de choix pour divers types de fonctionnement laser. Un fonctionnement laser continu accordable entre 1000 et 1060nm et un rendement de conversion de 25% (par rapport au rayonnement de pompage optique incident) ont été déjà obtenus.

  10. Calendar of Selected Aeronautical and Space Meetings (Calendrier des Manifestations Aeronautiques et Spatiales (Selection)).

    DTIC Science & Technology

    1983-01-01

    Physique de l’Atmosphire et Environnement terrestre 71 09 - Information, Documentation et Informatique 74 10 - Thimes gin~raux (pluridisciplinaires) et...March Louisiana (US) Fiber Communication Optical Communications IEEE Fibre Optics Electro-Optics 02-08 7-9 March Baden-Baden VDE -IEEE Specialists...Conference on Very Large Electronic Systems VDE (GE) Scale Integrated Circuits Solid State Devices IEEE Integrated Circuits Engineering Design Fabrication

  11. Chronic EtOH effects on putative measures of compulsive behavior in mice

    PubMed Central

    Radke, Anna K.; Jury, Nicholas J.; Kocharian, Adrina; Marcinkiewcz, Catherine A.; Lowery-Gionta, Emily G.; Pleil, Kristen E.; McElligott, Zoe A.; McKlveen, Jessica M.; Kash, Thomas L.; Holmes, Andrew

    2015-01-01

    Addictions, including alcohol use disorders (AUDs), are characterized by the loss of control over drug seeking and consumption, but the neural circuits and signaling mechanisms responsible for the transition from controlled use to uncontrolled abuse remain incompletely understood. Prior studies have shown that ‘compulsive-like’ behaviors in rodents, e.g., persistent responding for ethanol (EtOH) despite punishment, are increased after chronic exposure to EtOH. The main goal of the current study was to assess the effects of chronic intermittent EtOH (CIE) exposure on multiple, putative measures of compulsive-like EtOH seeking in C57BL/6J mice. Mice were exposed to two or four weekly cycles of CIE and then, post-withdrawal, tested for progressive ratio responding for EtOH, sustained responding during signaled EtOH-unavailability and (footshock) punished-suppression of responding for EtOH. Results showed that mice exposed to CIE exhibited attenuated suppression of EtOH-seeking during punishment, as compared to air-exposed controls. By contrast, CIE exposure affected neither punished food reward-seeking behavior, nor other putative measures of compulsive-like EtOH-seeking. Ex vivo RT-PCR analysis of brain tissue found reduced sensitivity to punished EtOH-seeking after CIE exposure was accompanied by a significant increase in gene expression of the GluN1 and GluN2A subunits of the N-methyl-D-aspartate receptor (NMDAR), specifically in the medial orbitofrontal cortex (mOFC). Moreover, slice electrophysiological analysis revealed increased NMDAR-mediated currents in the mOFC after CIE exposure in test-naïve mice. Collectively, the current findings add to growing body of evidence demonstrating that chronic exposure to EtOH fosters resistance to punished EtOH-seeking in association with adaptations in cortical glutamatergic transmission. PMID:26687341

  12. Complete Genome Sequence of EtG, the First Phage Sequenced from Erwinia tracheiphila.

    PubMed

    Andrade-Domínguez, Andrés; Kolter, Roberto; Shapiro, Lori R

    2018-02-22

    Erwinia tracheiphila is the causal agent of bacterial wilt of cucurbits. Here, we report the genome sequence of the temperate phage EtG, which was isolated from an E. tracheiphila -infected cucumber plant. Phage EtG has a linear 30,413-bp double-stranded DNA genome with cohesive ends and 45 predicted open reading frames. Copyright © 2018 Andrade-Domínguez et al.

  13. Selective photocatalytic transformations on microporous titanosilicate ETS-10 driven by size and polarity of molecules.

    PubMed

    Shiraishi, Yasuhiro; Tsukamoto, Daijiro; Hirai, Takayuki

    2008-11-04

    Photocatalytic activity of microporous titanosilicate ETS-10 has been studied in water. The photoactivated ETS-10 shows catalytic activity driven by size and polarity of substrates. ETS-10 efficiently catalyzes a conversion of substrates with a size larger than the pore diameter of ETS-10. In contrast, the reactivity of small substrates depends strongly on substrate polarity; less polar substrates show higher reactivity on ETS-10. Electron spin resonance analysis reveals that large substrates or less polar substrates scarcely diffuse inside the highly polarized micropores of ETS-10 and, hence, react efficiently with hydroxyl radicals (*OH) formed on titanol (Ti-OH) groups exposed on the external surface of ETS-10. In contrast, small polar substrates diffuse easily inside the micropores of ETS-10 and scarcely react with *OH, resulting in low reactivity. The photocatalytic activity of ETS-10 is successfully applicable to selective transformations of large reactants or less polar reactants to small polar products, enabling highly selective dehalogenation and hydroxylation of aromatics.

  14. Mariage non consommé et vaginisme: à propos de trois cas Clinique

    PubMed Central

    2017-01-01

    Le vaginisme est un problème de couple. Il est source de mariages non consommés, d’infertilité et d’altération de la qualité de la relation sexuelle du couple. Par trois cas cliniques illustratifs rapportés de notre pratique clinique quotidienne et suivis sur deux années en consultation du service de psychiatrie de l’Hôpital Militaire Moulay Ismail de Meknès, nous essayons de clarifier les motifs de rencontre pour vaginisme, ses aspects cliniques et relationnels et ses particularités culturelles. PMID:28819482

  15. [An aortic and femoral aneurysm revealing Behçet's disease].

    PubMed

    Lyazidi, Y; Abissegue, Y; Chtata, H T; Taberkant, M

    2015-12-01

    Vascular involvement in Behçet's disease is rare, but may be inaugural in many cases. We report a case of Behçet's disease revealed by two pre-rupture aneurysms - a subrenal abdominal aortic aneurysm and a femoral aneurysm. This patient had only one of the International Study Group for Behçet's disease diagnostic criteria: pseudofolliculitis. Behçet's disease must be considered as a possible diagnosis in patients with unexplained inflammatory arteriopathy. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  16. Evaluation of observation-driven evaporation algorithms: results of the WACMOS-ET project

    NASA Astrophysics Data System (ADS)

    Miralles, Diego G.; Jimenez, Carlos; Ershadi, Ali; McCabe, Matthew F.; Michel, Dominik; Hirschi, Martin; Seneviratne, Sonia I.; Jung, Martin; Wood, Eric F.; (Bob) Su, Z.; Timmermans, Joris; Chen, Xuelong; Fisher, Joshua B.; Mu, Quiaozen; Fernandez, Diego

    2015-04-01

    Terrestrial evaporation (ET) links the continental water, energy and carbon cycles. Understanding the magnitude and variability of ET at the global scale is an essential step towards reducing uncertainties in our projections of climatic conditions and water availability for the future. However, the requirement of global observational data of ET can neither be satisfied with our sparse global in-situ networks, nor with the existing satellite sensors (which cannot measure evaporation directly from space). This situation has led to the recent rise of several algorithms dedicated to deriving ET fields from satellite data indirectly, based on the combination of ET-drivers that can be observed from space (e.g. radiation, temperature, phenological variability, water content, etc.). These algorithms can either be based on physics (e.g. Priestley and Taylor or Penman-Monteith approaches) or be purely statistical (e.g., machine learning). However, and despite the efforts from different initiatives like GEWEX LandFlux (Jimenez et al., 2011; Mueller et al., 2013), the uncertainties inherent in the resulting global ET datasets remain largely unexplored, partly due to a lack of inter-product consistency in forcing data. In response to this need, the ESA WACMOS-ET project started in 2012 with the main objectives of (a) developing a Reference Input Data Set to derive and validate ET estimates, and (b) performing a cross-comparison, error characterization and validation exercise of a group of selected ET algorithms driven by this Reference Input Data Set and by in-situ forcing data. The algorithms tested are SEBS (Su et al., 2002), the Penman- Monteith approach from MODIS (Mu et al., 2011), the Priestley and Taylor JPL model (Fisher et al., 2008), the MPI-MTE model (Jung et al., 2010) and GLEAM (Miralles et al., 2011). In this presentation we will show the first results from the ESA WACMOS-ET project. The performance of the different algorithms at multiple spatial and temporal

  17. Qualité des certificats de coups et blessures volontaires sur adultes à Dakar et Diourbel, Sénégal

    PubMed Central

    Soumah, Mohamed Maniboliot; Ngwa, Hugues Elie Elame; Ndiaye, Mor; Sow, Mamadou Lamine

    2011-01-01

    Introduction Le certificat médical est une attestation écrite, destinée à constater un fait d'ordre médical. L'intérêt de cette étude résultait de la fréquence du contentieux entre représentants de la loi et médecins à propos des certificats médicaux descriptifs de coups et blessures volontaires. Les objectifs étaient d’étudier les critères d’établissement des certificats médicaux dans les cas de coups et blessures volontaires, d’évaluer la qualité des certificats médicaux dans les procédures judiciaires dans les régions de Dakar et de Diourbel, d'apprécier l’évaluation de l'Incapacité Totale de Travail fixée par les médecins et leurs implications judiciaires. Méthodes Nous avons étudié 201 certificats descriptifs de constatation de coups et blessures volontaires. L'incapacité totale de travail (ITT) au sens pénal a été revue par un médecin légiste. Les données recueillies ont été saisies et analysées par logiciel Epi Data version 3.1 et Epi Info 6.04. Résultats Le nom et les prénoms du médecin étaient mentionnés sur les 201 certificats. Sur les 201 certificats étudiés, 170 mentionnaient les faits rapportés par la victime. En proposant de manière comparative pour chacune des ITT fixées par le médecin, une ITT pénale, nous trouvions des erreurs entre ITT pénale et ITT civile (dans 95% des cas). Conclusion Les certificats médicaux délivrés sont incomplets. Les recommandations concernent la création d'unités médico-judiciaires et de centres d'accueil des victimes d'agression. PMID:22384305

  18. Etude hyperfrequence et ultrasonore des supraconducteurs organiques kappa-(ET)(2)X (X = copper(thiocyanogen), copper[N(CN)(2)]bromine)

    NASA Astrophysics Data System (ADS)

    Frikach, Kamal

    2001-09-01

    Dans ce travail je presente une etude de l'impedance de surface, ainsi que de l'attenuation et la variation de la vitesse ultrasonores dans les etats normal et supraconducteur sur les composes organiques k-(ET)2X (X = Cu(SCN) 2, Cu[N(CN)2]Br). A partir des mesures d'impedance de surface, les deux composantes sigma 1 et sigma2 de la conductivite complexe sont extraites en utilisant le modele de Drude. Ces mesures montrent que la symetrie du parametre d'ordre dans ces composes est differente de celle du cas BCS. Afin de comprendre le profil de sigma1 (T) nous avons etudie les fluctuations supraconductrices a partir de la paraconductivite sigma'( T). Cette etude est rendue possible grace a la structure quasi-2D des composes k-(ET)2X dans lesquelles les fluctuations supraconductrices sont fortes. Ces dernieres sont observees sur deux decades de temperatures dans le Cu(SCN)2. L'application du modele de Aslamazov-Larkin 2D et 3D montre la possibilite du passage du regime 2D a haute temperature au regime 3D au voisinage de Tc. En se basant sur ce resultat, nous avons calcule la paraconductivite en utilisant une approche a l'ordre d'une boucle a partir du modele de Lawrence-Doniach. En tenant compte de la correction par la self energie dans la limite dynamique (17 GHz), l'ajustement de la paraconductivite calculee est en bon accord avec les donnees experimentales. Le couplage interplan obtenu est compatible avec le caractere quasi-2D des composes organiques. Le temps de relaxation des quasi-particules dans l'etat supraconducteur est ensuite extrait pour la premiere fois dans ces composes dont le comportement en fonction de la temperature est compatible avec la presence des noeuds dans le gap. Dans l'etat normal, la variation de la vitesse ultrasonore presente un comportement anormal caracterise par un fort ramollissement a T = 38 K et 50 K dans k-(ET) 2Cu(SCN)2 et k-(ET)2Cu[N(CN) 2]Br respectivement dont l'amplitude est independante du champ magnetique jusqu'a H = Hc 2

  19. Calendar of Selected Aeronautical and Space Meetings January 1991 Onwards (Calendrier des Manifestations Aeronautiques et Spatiales (Selection) Janvier 1991 et au-dela)

    DTIC Science & Technology

    1990-12-01

    e 39 08 - Physique de l’Atmosph~re et Environnement terrestre 55 09 - Information, Documentation et Informatique 58 10 - Th~rnes g6n6raux...Fax (02) 692 2012 OS UV University of Vienna: Liebigasse 4/3-4, A- 1010 Wien Tel 43.1.43.67.12 Fax 43.1.43.01.97 AU VDE Verband Deutscher

  20. Substitution of lysine-181 to aspartic acid in the third transmembrane region of the endothelin (ET) type B receptor selectively reduces its high-affinity binding with ET-3 peptide.

    PubMed

    Mauzy, C; Wu, L H; Egloff, A M; Mirzadegan, T; Chung, F Z

    1992-01-01

    In the G protein-coupled receptor family, a highly conserved aspartic acid located within the third transmembrane domain has been shown to be involved in ligand binding. Within the endothelin (ET) peptide receptor family, this aspartic acid has been replaced by a lysine. To assess the importance of this residue in ET binding, the lysine (position 181) of rat ET type B receptor was replaced by an aspartic acid. The effects on ligand binding and phosphoinositide turnover of both the wild-type and K181D mutant receptors were examined using transient receptor expression in COS-7 cells. Using [125I]ET-1 as the radioactive peptide ligand in displacement binding studies, the wild-type receptor displayed a typical non-isopeptide-selective binding profile with similar IC50 values (0.2-0.6 nM) for all three ET peptides (ET-1, ET-2, and ET-3). The mutant receptor showed an increase in IC50 values for ET-1 (5 nM), ET-2 (27 nM), and ET-3 (127 nM). The K181D mutant receptor still elicited full inositol phosphate (IP) accumulation responses in the presence of saturating concentrations of ETs (10 nM of ET-1, 100 nM of ET-2, or 1 microM of ET-3), indicating that the mutation did not affect G protein coupling.

  1. Cerebral venous thrombosis in Behçet's disease.

    PubMed

    Saadoun, D; Wechsler, B; Resche-Rigon, M; Trad, S; Le Thi Huong, D; Sbai, A; Dormont, D; Amoura, Z; Cacoub, P; Piette, J C

    2009-04-15

    To analyze the clinical findings, treatment, outcome, and prevalence of cerebral venous thrombosis (CVT) in a large cohort of patients with Behçet's disease (BD) from a single center. We reported a series of 64 consecutive patients with CVT who fulfilled the international criteria for BD. Multivariate analysis was performed to define factors that affect prognosis. Among a cohort of 820 patients with BD, CVT was present in 64 (7.8%). Compared with BD patients without CVT, those with CVT had lower parenchymal central nervous system involvement (4.7% versus 28.7%; P = 0.0001) and higher extraneurologic vascular lesions (62.5% versus 38.8%; P = 0.03). Up to 90% of patients responded to anticoagulation therapy without severe hemorrhagic complications. Neither steroid nor immunosuppressant use provided better outcome. Severe visual loss due to optic atrophy was the main complication of CVT, being found in 15% of patients. In multivariate analysis, papilledema (odds ratio [OR] 7.1, 95% confidence interval [95% CI] 1.6-31.9) and concurrent prothrombotic risk factors (OR 4.6, 95% CI 1.1-20.2) were independently associated with the occurrence of sequelae. Factors associated with relapse of thrombosis were concurrent prothrombotic risk factors (hazard ratio [HR] 4.9, 95% CI 1.5-15.4) and a peripheral venous thrombosis (HR 2.8, 95% CI 0.7-10.5). After a mean +/- SD followup of 8.2 +/- 6.9 years, 4 deaths unrelated to CVT were noted. CVT in patients with BD may result in serious neurologic outcomes. Anticoagulation represents a safe and effective therapy. Extensive investigation of prothrombotic disorders should be considered.

  2. Azathioprine in severe uveitis of Behçet's disease.

    PubMed

    Saadoun, D; Wechsler, B; Terrada, C; Hajage, D; Le Thi Huong, D; Resche-Rigon, M; Cassoux, N; Le Hoang, P; Amoura, Z; Bodaghi, B; Cacoub, P

    2010-12-01

    To investigate the efficacy and tolerance of azathioprine in severe uveitis related to Behçet's disease (BD). We reported 157 consecutive patients with severe uveitis (active posterior uveitis or panuveitis) fulfilling the international criteria for BD and treated with corticosteroids (0.5-1 mg/kg/day) and azathioprine (2.5 mg/kg/day). Long-term outcome and factors associated with complete remission were assessed. Mean±SD age at diagnosis was 29.9±10.1 years, with 71.3% men. At baseline, 59 patients (37.6%) had loss of useful vision, 54 (34.4%) had retinal vasculitis, 66 (42.0%) had panuveitis, and 132 (84.1%) had bilateral uveitis. Following azathioprine therapy, 81 patients (51.6%) were complete responders, 65 (41.4%) were partial responders, and 11 (7%) were nonresponders. The visual acuity significantly improved (P<0.001), and a significant decrease in the mean oral prednisone dosage (55.3 to 10.5 mg/day; P<0.001) was observed after therapy. Patients with retinal vasculitis (odds ratio [OR] 0.45 [95% confidence interval (95% CI) 0.2-0.9], P=0.02) and severe visual loss (OR 0.28 [95% CI 0.2-0.7], P<0.0001) at diagnosis were less likely to be complete responders. Azathioprine was well tolerated, with only 3 withdrawals due to hepatotoxic effects (n=2) and bacterial septicemia (n=1). Azathioprine represents an effective and safe therapy in patients with severe uveitis of BD. Copyright © 2010 by the American College of Rheumatology.

  3. One year in review 2016: Behçet's syndrome.

    PubMed

    Hatemi, Gulen; Seyahi, Emire; Fresko, Izzet; Talarico, Rosaria; Hamuryudan, Vedat

    2016-01-01

    Several articles highlighting the epidemiology, pathogenesis, clinical features, treatment modalities and disease assessment of Behçet's syndrome (BS) have been published during the last year. Clinical and radiological features of lower extremity deep vein thrombosis due to BS can be quite different than those found in thrombosis due to other causes; additionally, frequency of post-thrombotic syndrome is significantly increased in BS. Some clinical and colonoscopic features are useful in differentiating BS from Crohn's disease. Barkhof criteria may be helpful in differentiating neurologic involvement due to BS from multiple sclerosis. Anatomical localization of papulopustular lesions but not histology has been found to be helpful in differentiating papulopustular lesions of BS from those found in acne vulgaris. Several studies looked at the ovarian reserve with contradicting results. A population-based cohort study found higher risk of hematological malignancies only among female BS patients living in Taiwan. The role of genetic factors and environment is discussed and both autoimmune and autoinflammatory features are underlined in the pathogenesis of BS. New data on the epistatic interactions between ERAP and HLA B51 is available and information on the microbiome have started to appear. New uncontrolled data suggest beneficial effects of anti-TNFs for refractory extra-ocular complications of BS such as pulmonary artery, gastrointestinal and central nervous system involvement. Uncontrolled studies suggest promising results with interleukin-1 inhibition but gevokizumab, a humanised anti IL-1β antibody, failed to meet the primary endpoint of time to first ocular exacerbation in a phase III trial. The debate on anticoagulation continues with new observational data.

  4. Carpal Tunnel Syndrome in Behçet's Disease.

    PubMed

    Lee, Jungsoo; Cho, Suhyun; Kim, Do Young; Zheng, Zhenlong; Park, Hoon; Bang, Dongsik

    2015-07-01

    Behçet's disease (BD) is a chronic inflammatory disease characterized by orogenital ulcers, skin and ocular lesions, in addition to articular, vascular, and neurologic symptoms. Carpal tunnel syndrome (CTS), can also occur in BD patients secondary to inflammation in the connective tissues, vessels, and tendons, as well as nerve involvement in BD itself. However, reports of patients who have CTS in BD are rare. The aim of this study was to evaluate the clinical characteristics of CTS in BD patients. Retrospective analysis of the medical records of 1750 BD patients, and 14 (0.8%) BD patients who were diagnosed with CTS was performed at the BD Specialty Clinic of Severance Hospital. Patient demographics, disease activity/severity for both diseases, and the clinical characteristics of CTS in BD were recorded and analyzed. All 14 BD patients with CTS were women. Twelve patients (85.7%) were diagnosed with active BD. The CTS was mild in 8 patients (57.2%), moderate in 3 patients (21.4%), and severe in 3 patients (21.4%). Ten patients (71.4%) had BD prior to the diagnosis of CTS, and these 10 patients all had active BD. CTS can occur as a result of the inflammation associated with BD and can also be the presenting symptom of nerve involvement in BD. CTS can also develop as the initial symptom of BD. Therefore, a higher degree of suspicion should be maintained for CTS in patients with BD and vice versa; however, the exact relationship is uncertain.

  5. One year in review 2017: Behçet's syndrome.

    PubMed

    Hatemi, Gulen; Seyahi, Emire; Fresko, Izzet; Talarico, Rosaria; Hamuryudan, Vedat

    2017-01-01

    A meta-analysis showed that methodological differences in prevalence studies such as a sample survey design or census design may be responsible for some of the variance in BS prevalence reported across countries, in addition to a true geographic variation. Efforts towards developing a data driven core set of outcome measures for clinical trials is continuing. Multimodal imaging using color fundus photography, fluorescein angiography, and optical coherence tomography is essential in visualising diagnostic features, detecting structural changes, and monitoring disease activity and response to treatment in Behçet's uveitis. Haemoptysis could also be due to bronchial artery enlargement in BS patients with pulmonary artery involvement and can be effectively treated with embolisation. Recent studies shed light on the link between immune system and thrombosis: fibrin clots seemed to be structurally different and plasmin resistant in BS. Newer genetic associations using immunochip were determined, but HLA-B51 is still the principal genetic link. Various studies on micro-RNA's, important molecules of immune regulation were published and discussed. Anti-TNF agents are still the key biologics for the treatment of various manifestations of BS. Two Phase III trials enrolling a small number of BS patients have shown the efficacy of adalimumab in the treatment of non-infectious, non-anterior uveitis. Interferon-alpha was found to induce long-lasting drug free remissions in a retrospective study. Small observational studies with non-TNF biologics such as ustekinumab, anakinra and canakinumab report beneficial results which await confirmation with further studies.

  6. Cadmium telluride leaching behavior: Discussion of Zeng et al. (2015).

    PubMed

    Sinha, Parikhit

    2015-11-01

    Zeng et al. (2015) evaluate the leaching behavior and surface chemistry of II-VI semiconductor materials, CdTe and CdSe, in response to pH and O2. Under agitation in acidic and aerobic conditions, the authors found approximately 3.6%-6.4% (w/w) solubility of Cd content in CdTe in the Toxicity Characteristic Leaching Procedure (TCLP), Waste Extraction Test (WET), and dissolution test, with lower solubility (0.56-0.58%) under agitation in acidic and anoxic conditions. This range is comparable with prior long-term transformation and dissolution testing and bio-elution testing of CdTe (2.3%-4.1% w/w solubility of Cd content in CdTe). The implications for potential leaching behavior of CdTe-containing devices require further data. Since CdTe PV modules contain approximately 0.05% Cd content by mass, the starting Cd content in the evaluation of CdTe-containing devices would be lower by three orders of magnitude than the starting Cd content in the authors' study, and leaching potential would be further limited by the monolithic glass-adhesive laminate-glass structure of the device that encapsulates the semiconductor material. Experimental evaluation of leaching potential of CdTe PV modules crushed by landfill compactor has been conducted, with results of TCLP and WET tests on the crushed material below regulatory limits for Cd. CdTe PV recycling technology has been in commercial operation since 2005 with high yields for semiconductor (95%) and glass (90%) recovery. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Coloring, bleaching, and perming: influence on EtG content in hair.

    PubMed

    Kerekes, Isabelle; Yegles, Michel

    2013-08-01

    Hair analysis of ethyl glucuronide (EtG) has become, beside fatty acid ethyl ester, a valuable marker for the detection of moderate and chronic excessive alcohol consumption. So far, only few studies exist about the influence of cosmetic treatment on EtG content in hair. The aim of this study was to evaluate the effect of coloring, bleaching, and perming on the concentration of this alcohol marker in hair. Studies were also performed to evaluate the chemical stability of EtG in the presence of hydrogen peroxide and ammonium thioglycolate. Six air samples were treated in vitro by the different commercial cosmetics following the suppliers' instructions. After washing, pulverization, incubation in ultrasonic bath, and solid phase extraction, EtG was determined by GC/MS-NICI after solid phase extraction and heptafluorobutyric anhydride derivatization. The results showed that samples (n = 10) treated with the coloring product did not show any important change in the EtG results. In the bleaching study (n = 23), a mean decrease of 73.5% was observed. After incubation of a solution of EtG with hydrogen peroxide (15%), a decrease of 45% was shown supporting the hypothesis of a chemical degradation of EtG and a leaching out effect from the hair matrix. In the perm treatment study (n = 23), a mean decrease of 95.7% of EtG was found. Incubation of a solution of EtG with ammonium thioglycolate (5%) showed a total decrease of EtG supporting the hypothesis of a chemical degradation. Coloring treatment did not importantly influence EtG content in hair. However, an important decrease of EtG in hair could be found after bleaching and permanent wave treatment. This decrease seems to be because of a chemical degradation of EtG, after bleaching, and a leaching out effect from the matrix. After perming, it seems to be more of a chemical degradation of EtG. These data have to be considered for the correct interpretation of EtG amounts in hair.

  8. The Transcription Factors Ets1 and Sox10 Interact During Murine Melanocyte Development

    PubMed Central

    Saldana-Caboverde, Amy; Perera, Erasmo M.; Watkins-Chow, Dawn; Hansen, Nancy F.; Vemulapalli, Meghana; Mullikin, James C; Pavan, William J.; Kos, Lidia

    2015-01-01

    Melanocytes, the pigment-producing cells, arise from multipotent neural crest (NC) cells during embryogenesis. Many genes required for melanocyte development were identified using mouse pigmentation mutants. The variable spotting mouse pigmentation mutant arose spontaneously at the Jackson Laboratory. We identified a G-to-A nucleotide transition in exon 3 of the Ets1 gene in variable spotting, which results in a missense G102E mutation. Homozygous variable spotting mice exhibit sporadic white spotting. Similarly, mice carrying a targeted deletion of Ets1 exhibit hypopigmentation; nevertheless, the function of Ets1 in melanocyte development is unknown. The transcription factor Ets1 is widely expressed in developing organs and tissues, including the NC. In the chick, Ets1 is required for the expression of Sox10, a transcription factor critical for the development of various NC derivatives, including melanocytes. We show that Ets1 is required early for murine NC cell and melanocyte precursor survival in vivo. Given the importance of Ets1 for Sox10 expression in the chick, we investigated a potential genetic interaction between these genes by comparing the hypopigmentation phenotypes of single and double heterozygous mice. The incidence of hypopigmentation in double heterozygotes was significantly greater than in single heterozygotes. The area of hypopigmentation in double heterozygotes was significantly larger than would be expected from the addition of the areas of hypopigmentation of single heterozygotes, suggesting that Ets1 and Sox10 interact synergistically in melanocyte development. Since Sox10 is also essential for enteric ganglia development, we examined the distal colons of Ets1 null mutants and found a significant decrease in enteric innervation, which was exacerbated by Sox10 heterozygosity. At the molecular level, Ets1 was found to activate an enhancer critical for Sox10 expression in NC-derived structures. Furthermore, enhancer activation was

  9. Variation of Annual ET Determined from Water Budgets Across Rural Southeastern Basins Differing in Forest Types

    NASA Astrophysics Data System (ADS)

    Younger, S. E.; Jackson, C. R.

    2017-12-01

    In the Southeastern United States, evapotranspiration (ET) typically accounts for 60-70% of precipitation. Watershed and plot scale experiments show that evergreen forests have higher ET rates than hardwood forests and pastures. However, some plot experiments indicate that certain hardwood species have higher ET than paired evergreens. The complexity of factors influencing ET in mixed land cover watersheds makes identifying the relative influences difficult. Previous watershed scale studies have relied on regression to understand the influences or low flow analysis to indicate growing season differences among watersheds. Existing studies in the southeast investigating ET rates for watersheds with multiple forest cover types have failed to identify a significant forest type effect, but these studies acknowledge small sample sizes. Trends of decreasing streamflow have been recognized in the region and are generally attributed to five key factors, 1.) influences from multiple droughts, 2.) changes in distribution of precipitation, 3.) reforestation of agricultural land, 4.) increasing consumptive uses, or 5.) a combination of these and other factors. This study attempts to address the influence of forest type on long term average annual streamflow and on stream low flows. Long term annual ET rates were calculated as ET = P-Q for 46 USGS gaged basins with daily data for the 1982 - 2014 water years, >40% forest cover, and no large reservoirs. Land cover data was regressed against ET to describe the relationship between each of the forest types in the National Land Cover Database. Regression analysis indicates evergreen land cover has a positive relationship with ET while deciduous and total forest have a negative relationship with ET. Low flow analysis indicates low flows tend to be lower in watersheds with more evergreen cover, and that low flows increase with increasing deciduous cover, although these relationships are noisy. This work suggests considering forest

  10. The role of Rho-kinase and calcium ions in constriction triggered by ET-1.

    PubMed

    Wiciński, Michał; Szadujkis-Szadurska, Katarzyna; Węclewicz, Mateusz M; Malinowski, Bartosz; Matusiak, Grzegorz; Walczak, Maciej; Wódkiewicz, Eryk; Grześk, Grzegorz; Pawlak-Osińska, Katarzyna

    2018-05-05

    Endothelin-1 (ET-1) is one of the key factors regulating tension of smooth muscles in blood vessels. It is believed that ET-1 plays an important role in pathogenesis of hypertension, and cardiovascular diseases; therefore, research in order to limit ET-1-mediated action is still in progress. The main objective of this paper was to evaluate the role of Rho-kinase in the ET-1-induced constriction of arteries. The analysis also included significance of intra- and extracellular pool of calcium ions in constriction triggered by ET-1. The studies were performed on perfused Wistar rat tail arteries. Concentration response curve (CRC) was determined for ET-1 in the presence of increased concentrations of Rho-kinase inhibitor (Y-27632) and IP3-receptor antagonist (2APB), both in reference to constriction triggered by solely ET-1. Afterwards, the influence of calcium ions present in the perfusion fluid was evaluated in terms of the effect triggered by 2APB and occurring in arteries constricted by ET-1. ET-1, in concentration dependent manner, leads to increase in perfusion pressure. Y-27632 and 2APB lead to shift of the concentration response curve for ET-1 to the right with simultaneously lowered maximum effect. There was no difference in reaction of the artery constricted by ET-1 and treated with 2APB in solution containing calcium and in calcium-free solution. Vasoconstrictive action of endothelin is not significantly dependent on the inflow of extracellular calcium, but it is proportional to inflow of Ca 2+ related to activation of IP3 receptors and to Rho-kinase activity. Copyright © 2018. Published by Elsevier Inc.

  11. [Molecular mechanism for ET-1-induced insulin resistance in skeletal muscle cells].

    PubMed

    Horinouchi, Takahiro; Mazaki, Yuichi; Terada, Koji; Miwa, Soichi

    2018-01-01

    Insulin resistance is a condition where the sensitivity to insulin of the tissues expressing insulin receptor (InsR) is decreased due to a functional disturbance of InsR-mediated intracellular signaling. Insulin promotes the entry of glucose into the tissues and skeletal muscle is the most important tissue responsible for the insulin's action of decreasing blood glucose levels. Endothelin-1 (ET-1), a potent vasoconstrictor and pro-inflammatory peptide, induces insulin resistance through a direct action on skeletal muscle. However, the signaling pathways of ET-1-induced insulin resistance in skeletal muscle remain unclear. Here we show molecular mechanism underlying the inhibitory effect of ET-1 on insulin-stimulated Akt phosphorylation and glucose uptake in myotubes of rat L6 skeletal muscle cell line. mRNA expression levels of differentiation marker genes, MyoD and myogenin, were increased during L6 myoblasts differentiation into myotubes. Some of myotubes possessed the ability to spontaneously contract. In myotubes, insulin promoted Akt phosphorylation at Thr 308 and Ser 473 , and [ 3 H]-labelled 2-deoxy-D-glucose ([ 3 H]2-DG) uptake. The insulin-facilitated Akt phosphorylation and [ 3 H]2-DG uptake were inhibited by ET-1. The inhibitory effect of ET-1 was counteracted by blockade of ET type A receptor (ET A R), inhibition of G q/11 protein, and siRNA knockdown of G protein-coupled receptor kinase 2 (GRK2). The exogenously overexpressed GRK2 directly bound to endogenous Akt and their association was facilitated by ET-1. In summary, activation of ET A R with ET-1 inhibits insulin-induced Akt phosphorylation and [ 3 H]2-DG uptake in a G q/11 protein- and GRK2-dependent manner in skeletal muscle. These findings indicate that ET A R and GRK2 are potential targets for insulin resistance.

  12. Novel RNA hybridization method for the in situ detection of ETV1, ETV4, and ETV5 gene fusions in prostate cancer.

    PubMed

    Kunju, Lakshmi P; Carskadon, Shannon; Siddiqui, Javed; Tomlins, Scott A; Chinnaiyan, Arul M; Palanisamy, Nallasivam

    2014-09-01

    The genetic basis of 50% to 60% of prostate cancer (PCa) is attributable to rearrangements in E26 transformation-specific (ETS) (ERG, ETV1, ETV4, and ETV5), BRAF, and RAF1 genes and overexpression of SPINK1. The development and validation of reliable detection methods are warranted to classify various molecular subtypes of PCa for diagnostic and prognostic purposes. ETS gene rearrangements are typically detected by fluorescence in situ hybridization and reverse-transcription polymerase chain reaction methods. Recently, monoclonal antibodies against ERG have been developed that detect the truncated ERG protein in immunohistochemical assays where staining levels are strongly correlated with ERG rearrangement status by fluorescence in situ hybridization. However, specific antibodies for ETV1, ETV4, and ETV5 are unavailable, challenging their clinical use. We developed a novel RNA in situ hybridization-based assay for the in situ detection of ETV1, ETV4, and ETV5 in formalin-fixed paraffin-embedded tissues from prostate needle biopsies, prostatectomy, and metastatic PCa specimens using RNA probes. Further, with combined RNA in situ hybridization and immunohistochemistry we identified a rare subset of PCa with dual ETS gene rearrangements in collisions of independent tumor foci. The high specificity and sensitivity of RNA in situ hybridization provides an alternate method enabling bright-field in situ detection of ETS gene aberrations in routine clinically available PCa specimens.

  13. Nuclear Membranes ETB Receptors Mediate ET-1-induced Increase of Nuclear Calcium in Human Left Ventricular Endocardial Endothelial Cells.

    PubMed

    Jules, Farah; Avedanian, Levon; Al-Khoury, Johny; Keita, Ramatoulaye; Normand, Alexandre; Bkaily, Ghassan; Jacques, Danielle

    2015-07-01

    In fetal human left ventricular endocardial endothelial cells (EECLs), both plasma membrane (PM) ET(A)R and ET(B)R were reported to mediate ET-1-induced increase of intracellular calcium [Ca](i); however, this effect was mediated by ET(A)R in right EECs (EECRs). In this study, we verified whether, as for the PM, nuclear membranes (NMs) ET-1 receptors activation in EECLs and EECRs induce an increase of nuclear calcium ([Ca](n)) and if this effect is mediated through the same receptor type as in PM. Using a plasmalemma-perforated technique and 3D confocal microscopy, our results showed that, as in PM intact cells, superfusion of nuclei of both cell types with cytosolic ET-1 induced a concentration-dependent sustained increase of [Ca](n). In EECRs, the ET(A)R antagonist prevented the effect of ET-1 on [Ca](n) without affecting EECLs. However, in both cell types, the effect of cytosolic ET-1 on [Ca](n) was prevented by the ETBR antagonist. In conclusion, both NMs' ET(A)R and ET(B)R mediated the effect of cytosolic ET-1 on [Ca](n) in EECRs. In contrast, only NMs' ET(B)R activation mediated the effect of cytosolic ET-1 in EECLs. Hence, the type of NMs' receptors mediating the effect of ET-1 on [Ca](n) are different from those of PM mediating the increase in [Ca](i).

  14. Influence des elements d'addition Ti, Nb, Al sur la structure et les proprietes mecaniques en traction et en fluage (de 298 A 1023 K) des alliages a base de fer et de nickel du type IN 706

    NASA Astrophysics Data System (ADS)

    Aubert, H.; Laniesse, J.; Lelong, C.; Pigoury, M.

    1981-09-01

    L'étude a porté sur 13 alliages du type IN 706 dont un alliage commercial et des alliages expérimentaux ayant une teneur en éléments durcissants niobium, titane, aluminium assez différente de celle de la nuance commerciale. On montre l'effet de la composition sur la structure et sur la cinétique de précipitation des phases stables et métastables. On décrit les propriétés mécaniques à l'état précipité: dureté, résistance à la traction, caractéristiques de fluage. Il est conclu que des alliages relativement pauvres en éléments durcissants peuvent convenir à la rélisation de gaines pour les réacteurs à neutrons rapides.

  15. Bushland Reference ET Calculator with QA/QC capabilities and iPhone/iPad application

    Accurate daily reference evapotranspiration (ET) values are needed to estimate crop water demand for irrigation management and hydrologic modeling purposes. The USDA-ARS Conservation and Production Research Laboratory at Bushland, Texas developed the Bushland Reference ET (BET) Calculator for calcul...

  16. Deriving hourly surface energy fluxes and ET from Landsat Thematic mapper data using METRIC

    Surface energy fluxes and evapotranspiration (ET) have long been recognized as playing an important role in determining exchanges of energy and mass between the hydrosphere, atmosphere, and biosphere. In this study, we applied the METRIC (Mapping ET at high Resolutions with Internal Calibration) alg...

  17. Rebuttal to Nelson et al. 'Response to Bodin and Grote regarding postdoctoral recruitment in clinical neuropsychology'.

    PubMed

    Bodin, Doug; Grote, Christopher L

    2016-07-01

    Nelson et al. provided a response to our commentary on the postdoctoral match in clinical neuropsychology. In this brief rebuttal, we will focus on statements from Nelson et al. that we believe are factual inaccuracies or misunderstandings of some of the points we made in our commentary. In addition, we will comment briefly on the proposed guidelines offered in their response.

  18. 75 FR 7637 - iShares Trust, et al.; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-22

    ... ETFs.\\5\\ \\4\\ See, e.g., South Asia Portfolio, SEC No-Action Letter (Mar. 12, 1997). \\5\\ Barclays Global... Global Fund Advisors, et al., Investment Company Act Release No. 26175 (Sep. 8, 2003), and Barclays Global Fund Advisors, et al., Investment Company Act Release No. 27417 (Jun. 23, 2006) (as amended, the...

  19. Examining American Post-Secondary Education. Research Report. ETS RR-11-22

    ERIC Educational Resources Information Center

    Liu, Ou Lydia

    2011-01-01

    The purpose of this report is to identify the most prominent issues in U.S. higher education and to develop strategic research plans to address the issues that are most relevant to ETS's capabilities in measurement and assessment through the ETS's higher education research initiative. In the United States, issues related to higher education such…

  20. 75 FR 36446 - Southern Nuclear Operating Company et al.; Notice of Availability of Environmental Assessment and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 52-011; NRC-2008-0252] Southern Nuclear Operating Company et al.; Notice of Availability of Environmental Assessment and Finding of No Significant Impact for License Amendment to Early Site Permit Issued to Southern Nuclear Operating Company et al., for Vogtle Electric Generating Plant ESP Site Located i...

  1. 75 FR 39284 - Southern Nuclear Operating Company et al.; Notice of Availability of Environmental Assessment and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 52-011; NRC-2008-0252] Southern Nuclear Operating Company et al.; Notice of Availability of Environmental Assessment and Finding of No Significant Impact for License Amendment to Early Site Permit Issued to Southern Nuclear Operating Company et al., for Vogtle Electric Generating Plant ESP Site Located I...

  2. 76 FR 29276 - Notice of Revised Determination on Reconsideration; Severstal Wheeling, Inc., et al.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-71,572, TA-W-71,572A, et al.] Notice of Revised Determination on Reconsideration; Severstal Wheeling, Inc., et al. TA-W-71,572 Severstal Wheeling, Inc., a Subsidiary of Severstal North America, Inc. Martins Ferry, Ohio TA-W-71,572A...

  3. Operational ET remote sensing (RS) program for irrigation scheduling and management: challenges and opportunities

    Prasanna Gowda

    2016-01-01

    Evapotranspiration (ET) is an essential component of the water balance and a major consumptive use of irrigation water and precipitation on cropland. Any attempt to improve water use efficiency must be based on reliable estimates of ET for irrigation scheduling purposes.

  4. 76 FR 30325 - Application to Export Electric Energy; E-T Global Energy, LLC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... Export Electric Energy; E-T Global Energy, LLC AGENCY: Office of Electricity Delivery and Energy... authority to transmit electric energy from the United States to Mexico pursuant to section 202(e) of the... an application from E-T Global for authority to transmit electric energy from the United States to...

  5. Identification and Function of Ets Target Genes Involved in Lung Cancer Progression

    DTIC Science & Technology

    2013-10-01

    Upadhyay et al., 2006). Tissues with Lkb1 mutations have higher Pea3 expression than wild type tissues (Upadhyay et al., 2006). In vitro, Pea3...with rotation. AG beads (Santa Cruz Biotechnology, Inc.), BSA (100 μg/ml), and salmon sperm (500 μg/ml) were added to samples. Samples were rotated (4

  6. Gaussian process models for reference ET estimation from alternative meteorological data sources

    Accurate estimates of daily crop evapotranspiration (ET) are needed for efficient irrigation management, especially in arid and semi-arid regions where crop water demand exceeds rainfall. Daily grass or alfalfa reference ET values and crop coefficients are widely used to estimate crop water demand. ...

  7. Missing lynx and trophic cascades in food webs: A reply to Ripple et al.

    John R. Squires; Nicholas J. DeCesare; Mark Hebblewhite; Joel Berger

    2012-01-01

    Ripple et al. (2011) proposed a hypothesis that the recovery of gray wolves (Canis lupus) may positively affect the viability of threatened Canada lynx (Lynx canadensis) populations in the contiguous United States through indirect species interactions. Ripple et al. (2011) proposed 2 key trophic linkages connecting wolf restoration with lynx recovery. First, recovering...

  8. 77 FR 56838 - Puget Sound Energy, Inc. v. All Jurisdictional Sellers, et al.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL01-10-097] Puget Sound Energy, Inc. v. All Jurisdictional Sellers, et al.; Notice of Filing Take notice that on July 12, 2012... Commission's June 13, 2012 Order, Puget Sound Energy, Inc. v. All Jurisdictional Sellers, et al., Order...

  9. 75 FR 63222 - Claymore Exchange-Traded Fund Trust, et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... Exchange-Traded Fund Trust, et al.; Notice of Application October 7, 2010. AGENCY: Securities and Exchange... Fund Trust, et al., Investment Company Act Release Nos. 27469 (Aug. 28, 2006) (notice) and 27483 (Sept... investment companies and unit investment trusts outside of the same group of investment companies as the...

  10. Risks and Consequences of Oversimplifying Educational Inequities: A Response to Morgan et al. (2015)

    ERIC Educational Resources Information Center

    Skiba, Russell J.; Artiles, Alfredo J.; Kozleski, Elizabeth B.; Losen, Daniel J.; Harry, Elizabeth G.

    2016-01-01

    In this technical comment, we argue that Morgan et al.'s claim that there is no minority overrepresentation in special education is in error due to (a) sampling considerations, (b) inadequate support from previous and current analyses, and (c) their failure to consider the complexities of special education disproportionality. [For Morgan et al.'s…

  11. No 129-L'exercice physique pendant la grossesse et le postpartum.

    PubMed

    Davies, Gregory A L; Wolfe, Larry A; Mottola, Michelle F; MacKinnon, Catherine

    2018-02-01

    Énoncer une directive canadienne visant à informer les fournisseurs de soins obstétricaux des répercussions, pour la mère, le fœtus et le nouveau-né, des exercices de conditionnement aerobique et musculaire pendant la grossesse. RéSULTATS ATTENDUS: Effets sur la morbidité maternelle, fœtale et néonatale et mesures de la forme physique maternelle. Une recherche sur MEDLINE des articles, publiés en anglais de 1966 à 2002, appartenant aux catégories suivantes : études sur le conditionnement aérobique et musculaire chez des femmes ne faisant pas jusque-là d'exercice et chez des femmes actives avant leur grossesse, ainsi que des études sur les répercussions du conditionnement aérobique et musculaire sur les issues précoces et tardives de la grossesse ou sur les issues néonatales; rapports de synthèse et méta-analyses portant sur l'exercice pendant la grossesse. Les résultats recueillis ont été revus par la Société des obstétriciens et gynécologues du Canada (Comité de la pratique clinique - obstétrique), avec la participation de la Société canadienne de physiologie de l'exercice, et ils ont été classés suivant les critères d'évaluation des preuves établis par le Groupe de travail canadien sur l'examen de santé périodique. VALIDATION: Cette directive a été approuvée par le Comité de pratique clinique - obstétrique de la SOGC, par le Comité exécutif et par le Conseil de la SOGC, ainsi que par le Conseil d'administration de la Société canadienne de physiologie de l'exercice. PARRAINé PAR: la Société des obstétriciens et gynécologues du Canada et par la Société canadienne de physiologie de l'exercice. Copyright © 2018. Published by Elsevier Inc.

  12. Evaluation experimentale et theorique du comportement a la flexion de nouveaux poteaux en materiaux composites

    NASA Astrophysics Data System (ADS)

    Metiche, Slimane

    La demande croissante en poteaux pour les differents reseaux d'electricite et de telecommunications a rendu necessaire l'utilisation de materiaux innovants, qui preservent l'environnement. La majorite des poteaux electriques existants au Canada ainsi qu'a travers le monde, sont fabriques a partir de materiaux traditionnels tel que le bois, le beton ou l'acier. Les motivations des industriels et des chercheurs a penser a d'autres solutions sont diverses, citons entre autre: La limitation en longueur des poteaux en bois ainsi que la vulnerabilite des poteaux fabriques en beton ou en acier aux agressions climatiques. Les nouveaux poteaux en materiaux composites se presentent comme de bons candidats a cet effet, cependant; leur comportement structural n'est pas connu et des etudes theoriques et experimentales approfondies sont necessaires avant leur mise en marche a grande echelle. Un programme de recherche intensif comportant plusieurs projets experimentaux, analytiques et numeriques est en cours a l'Universite de Sherbrooke afin d'evaluer le comportement a court et a long termes de ces nouveaux poteaux en Polymeres Renforces de Fibres (PRF). C'est dans ce contexte que s'inscrit la presente these, et notre recherche vise a evaluer le comportement a la flexion de nouveaux poteaux tubulaires coniques fabriques en materiaux composites par enroulement filamentaire et ce, a travers une etude theorique, ainsi qu'a travers une serie d'essais de flexion en "grandeur reelle" afin de comprendre le comportement structural de ces poteaux, d'optimiser la conception et de proposer une procedure de dimensionnement pour les utilisateurs. Les poteaux en Polymeres Renforces de Fibres (PRF) etudies dans cette these sont fabriques avec une resine epoxyde renforcee de fibres de verre type E. Chaque type poteaux est constitue principalement de trois zones ou les proprietes geometriques (epaisseur, diametre) et les proprietes mecaniques sont differentes d'une zone a l'autre. La difference

  13. PhET: The Best Education Software You Can't Buy

    NASA Astrophysics Data System (ADS)

    Dubson, M.; Duncan, D. K.

    2009-12-01

    Project PhET provides free educational software in the form of stand-alone java and flash simulations and associated classroom materials. Our motto is "It's the best educational software that money can buy, except you can't buy it, because its free." You can start playing with PhET sims right now at http://phet.colorado.edu and add to our 1 million hits per month. PhET originally stood for Physics Education Technology, but we now include other science fields so PhET is now a brand name. Our site has about 80 simulations, mostly in physics and math, but also in chemistry, geology, and biology. Based on careful research and student interviews, our sims have no instructions because no one reads instructions. These simulations can be used in lecture demonstrations, classroom activities, and homework assignments. The PhET site includes a long list of user-tested classroom activities and teacher tips.

  14. Glossary of Terms and Definitions Concerning the Safety and Suitability for Service of Munitions, Explosives and Related Products (Glossaire de Termes et Definitions sur la Securite et L’Aptitude au Service de Munitions, Matieres Explosives et Produits Associes)

    DTIC Science & Technology

    2002-04-01

    de mines à la mar jettisoned mine L lancement launch largage jettison largage de détresse en condition de sécurité safe...configuration logistique Etat des conditions d’un matériel prévu pour le stockage et le transport par voies de communication. Pour les munition...durée de vie en service, durée de vie opérationnelle, cycle de vie, conditions de stockage et de transit] ANNEX C to /ANNEXE C à

  15. Concordance et apports de l'hystérosalpingographie et de la cœlioscopie dans l'exploration tubaire et pelvienne en cas d'infertilité

    PubMed Central

    Kehila, Mehdi; Ben Hmid, Rim; Ben Khedher, Sonia; Mahjoub, Sami; Channoufi, Mohamed Bedis

    2014-01-01

    Introduction La coelioscopie et l'hystérosalpingographie sont les deux procédures usuellement admises pour l'exploration tubaire et pelvienne en cas d'infertilité. Les objectifs de ce travail etaient de comparer les données de l'Hystérosalpingographie à celles de la coelioscopie chez des patientes explorées pour infertilité et voir l'apport de l'une par rapport à l'autre. Méthodes Etude prospective menée au service C du centre de maternité et de néonatologie de Tunis, s’étendant sur 15 mois, colligeant 120 patientes suivies pour infertilité ayant bénéficié d'une HSG suivie d'une coelioscopie. Résultats L’âge moyen de nos patientes était de 35,3 ans. L'infertilité était primaire dans 56,7% des cas et secondaire dans 43,7% des cas. Sa durée moyenne était de 48,9 mois. Le test statistique de concordance Kappa entre les 2 examens était de 0.42 pour les obstructions tubaires en général, de 0.48 pour les obstructions tubaires proximales et de 0.53 pour les obstructions tubaires distales indiquant une concordance modérée dans tous les cas. La coelioscopie a permis d'objectiver en plus une endométriose pelvienne dans 7% des cas, des adhérences pelviennes dans 33% des cas et des trompes perméables mais d'aspect pathologique dans 20% des cas. Conclusion Il existe un intérêt d′associer, chaque fois que c′est possible, l'HSG et la coelioscopie dans l'exploration du pelvis féminin dans le cadre de l'infertilité. Aucun de ces deux examens n'est parfait. Leurs résultats sont complémentaires. PMID:25374631

  16. Endothelin Induces Rapid, Dynamin-mediated Budding of Endothelial Caveolae Rich in ET-B*

    PubMed Central

    Oh, Phil; Horner, Thierry; Witkiewicz, Halina; Schnitzer, Jan E.

    2012-01-01

    Clathrin-independent trafficking pathways for internalizing G protein-coupled receptors (GPCRs) remain undefined. Clathrin-mediated endocytosis of receptors including ligand-engaged GPCRs can be very rapid and comprehensive (<10 min). Caveolae-mediated endocytosis of ligands and antibodies has been reported to be much slower in cell culture (≫10 min). Little is known about the role of physiological ligands and specific GPCRs in regulating caveolae trafficking. Here, we find that one receptor for endothelin, ET-B but not ET-A, resides on endothelial cell surfaces in both tissue and cell culture primarily concentrated within caveolae. Reconstituted cell-free budding assays show that endothelins (ETs) induce the fission of caveolae from endothelial plasma membranes purified from rat lungs. Electron microcopy of lung tissue sections and tissue subcellular fractionation both show that endothelin administered intravascularly in rats also induces a significant loss of caveolae at the luminal surface of lung vascular endothelium. Endothelial cells in culture show that ET stimulates very rapid internalization of caveolae and cargo including caveolin, caveolae-targeting antibody, and itself. The ET-B inhibitor BQ788, but not the ET-A inhibitor BQ123, blocks the ET-induced budding of caveolae. Both the pharmacological inhibitor Dynasore and the genetic dominant negative K44A mutant of dynamin prevent this induced budding and internalization of caveolae. Also shRNA lentivirus knockdown of caveolin-1 expression prevents rapid internalization of ET and ET-B. It appears that endothelin can engage ET-B already highly concentrated in caveolae of endothelial cells to induce very rapid caveolae fission and endocytosis. This transport requires active dynamin function. Caveolae trafficking may occur more rapidly than previously documented when it is stimulated by a specific ligand to signaling receptors already located in caveolae before ligand engagement. PMID:22457360

  17. Simulation d'ecoulements internes compressibles laminaires et turbulents par une methode d'elements finis

    NASA Astrophysics Data System (ADS)

    Rebaine, Ali

    1997-08-01

    Ce travail consiste en la simulation numerique des ecoulements internes compressibles bidimensionnels laminaires et turbulents. On s'interesse, particulierement, aux ecoulements dans les ejecteurs supersoniques. Les equations de Navier-Stokes sont formulees sous forme conservative et utilisent, comme variables independantes, les variables dites enthalpiques a savoir: la pression statique, la quantite de mouvement et l'enthalpie totale specifique. Une formulation variationnelle stable des equations de Navier-Stokes est utilisee. Elle est base sur la methode SUPG (Streamline Upwinding Petrov Galerkin) et utilise un operateur de capture des forts gradients. Un modele de turbulence, pour la simulation des ecoulements dans les ejecteurs, est mis au point. Il consiste a separer deux regions distinctes: une region proche de la paroi solide, ou le modele de Baldwin et Lomax est utilise et l'autre, loin de la paroi, ou une formulation nouvelle, basee sur le modele de Schlichting pour les jets, est proposee. Une technique de calcul de la viscosite turbulente, sur un maillage non structure, est implementee. La discretisation dans l'espace de la forme variationnelle est faite a l'aide de la methode des elements finis en utilisant une approximation mixte: quadratique pour les composantes de la quantite de mouvement et de la vitesse et lineaire pour le reste des variables. La discretisation temporelle est effectuee par une methode de differences finies en utilisant le schema d'Euler implicite. Le systeme matriciel, resultant de la discretisation spatio-temporelle, est resolu a l'aide de l'algorithme GMRES en utilisant un preconditionneur diagonal. Les validations numeriques ont ete menees sur plusieurs types de tuyeres et ejecteurs. La principale validation consiste en la simulation de l'ecoulement dans l'ejecteur teste au centre de recherche NASA Lewis. Les resultats obtenus sont tres comparables avec ceux des travaux anterieurs et sont nettement superieurs concernant les

  18. Building a Catalog of Time-Dependent Inversions for Cascadia ETS Events

    NASA Astrophysics Data System (ADS)

    Bartlow, N. M.; Williams, C. A.; Wallace, L. M.

    2017-12-01

    Episodic Tremor and Slip (ETS), composed of periodically occurring slow slip events accompanied by tectonic tremor, have been recognized in Cascadia since 1999. While the tremor has been continuously and automatically monitored for a few years (Wech et al., SRL, 2010; pnsn.org/tremor), the geodetically-derived slip has not been systematically monitored in the same way. Instead, numerous time-dependent and static inversions of the geodetic data have been performed for individual ETS events, with many events going unstudied. Careful study of, and monitoring of, ETS is important both to advance the scientific understanding of fault mechanics and to improve earthquake hazard forecasting in Cascadia. Here we present the results of initial efforts to standardize geodetic inversions of slow slip during Cascadia ETS. We use the Network Inversion Filter (NIF, Segall and Matthews,1997; McGuire and Segall, 2003; Miyazaki et al.,2006), applied evenly to an extended time period, to detect and catalog slow slip transients. Bartlow et al., 2014, conducted a similar study for the Hikurangi subduction zone, covering a 2.5 year period. Additionally, we generate Green's functions using the PyLith finite element code (Aagaard et al., 2013) to allow consideration of elastic property variations derived from a Cascadia-wide seismic velocity model (Stephenson, USGS pub., 2007). These Green's functions are then integrated to provide Green's functions compatible with the Network Inversion Filter. The use of heterogeneous elastic Green's functions allows for a more accurate estimation of slip amplitudes, both during individual ETS events and averaged over multiple events. This is useful for constraining the total slip budget in Cascadia, including whether ETS takes up the entire plate motion on the deeper extent of the plate interface where it occurs. The recent study of Williams and Wallace, GRL, 2015 demonstrated that the use heterogeneous elastic Green's Functions in inversions can make a

  19. Dépistage des maladies cardiovasculaires chez des étudiants de l'Université de Douala et influence des activités physiques et sportives

    PubMed Central

    Ewane, Marielle Epacka; Mandengue, Samuel Honoré; Priso, Eugene Belle; Tamba, Stéphane Moumbe; Ahmadou; Fouda, André Bita

    2012-01-01

    Introduction Les maladies cardiovasculaires (MCV) constituent l'une des principales causes de mortalité dans les pays en développement. Le dépistage de ces dernières chez des jeunes est un défi dans la lutte contre leur expansion. Le but de cette étude était de dépister ces maladies au sein d'une population jeunes d’étudiants camerounais. Methodes Deux mille six cent cinquante-huit étudiants de l'Université de Douala (23,6 ± 2,9 ans, sex-ratio H/F = 0,9) ont en Avril - Mai 2011 participé à une campagne de dépistage gratuit du diabète, de l'hypertension artérielle (HTA) et de l'obésité. Ils ont également été soumis à une d'enquête évaluant leur niveau en activités physiques et sportives (APS). Resultats 12,7% des participants avaient une pression artérielle (PA) ≥ 140/90 mmHg, 3,6% étaient obèses et 0,9% avaient une glycémie ≥1,26 g/L. Des corrélations ont été trouvées entre certains facteurs de risque (diabète, hypertension et obésité) et le niveau académique d'une part (r =0,366; p < 0,0001) et le temps passé devant la télévision d'autres part (r = 0,411; p < 0,0001). L‘APS était inversement corrélée à l‘âge (r =-0,015; p < 0,0001) et au temps passé devant la télévision (r = -0,059; p = 0,002). Conclusion La présence des MCV et leurs facteurs de risque mis en évidence dans cette étude réalisée en milieu estudiantin camerounais interpelle à une prévention et une éducation dans la lutte contre ces dernières. PMID:22655111

  20. Amplitude and Width Manipulations in Fitts' Paradigm: Comment on Heath et al. (2011) and Heath et al. (2016).

    PubMed

    Hoffmann, Errol R

    2017-01-01

    Heath, Weiler, Marriott, Elliott, and Binstead ( 2011 ) and Heath, Samani, Tremblay, and Elliott ( 2016 ) have claimed that there are dissociable movement times for amplitude and width manipulations in the Fitts' paradigm. This may to some extent be true, but the Heath et al. ( 2011 ) and Heath et al. ( 2016 ) data do not support that contention, as shown in this comment. It is shown that data from the research of Heath et al. is not in the range of index of difficulty where ongoing visual control would be used and hence their fits of data to Fitts' law are spurious. The data of Heath et al. ( 2011 ) for arm movements and for the primary eye saccade submovements of Heath et al. ( 2016 ) are well correlated by the ballistic movement time equation of Hoffmann ( 1981 ) and Gan and Hoffmann ( 1988 ). When the ballistic equation is used to model data for constant amplitude and constant target width conditions, the effects of the amplitude and width manipulations disappear. Other research indicates that the independent effects of movement amplitude occur due to changes in the time for the distance-covering phase of the movement.

  1. Developpement et implementation d'une methode pour resoudre les equations de la couche limite laminaire et turbulente

    NASA Astrophysics Data System (ADS)

    Leuca, Maxim

    CFD (Computational Fluid Dynamics) is a computational tool for studying flow in science and technology. The Aerospace Industry uses increasingly the CFD modeling and design phase of the aircraft, so the precision with which phenomena are simulated boundary layer is very important. The research efforts are focused on optimizing the aerodynamic performance of airfoils to predict the drag and delay the laminar-turbulent transition. CFD codes must be fast and efficient to model complex geometries for aerodynamic flows. The resolution of the boundary layer equations requires a large amount of computing resources for viscous flows. CFD codes are commonly used to simulate aerodynamic flows, require normal meshes to the wall, extremely fine, and, by consequence, the calculations are very expensive. . This thesis proposes a new approach to solve the equations of boundary layer for laminar and turbulent flows using an approach based on the finite difference method. Integrated into a code of panels, this concept allows to solve airfoils avoiding the use of iterative algorithms, usually computing time and often involving convergence problems. The main advantages of panels methods are their simplicity and ability to obtain, with minimal computational effort, solutions in complex flow conditions for relatively complicated configurations. To verify and validate the developed program, experimental data are used as references when available. Xfoil code is used to obtain data as a pseudo references. Pseudo-reference, as in the absence of experimental data, we cannot really compare two software together. Xfoil is a program that has proven to be accurate and inexpensive computing resources. Developed by Drela (1985), this program uses the method with two integral to design and analyze profiles of wings at low speed (Drela et Youngren, 2014), (Drela, 2003). NACA 0012, NACA 4412, and ATR-42 airfoils have been used for this study. For the airfoils NACA 0012 and NACA 4412 the calculations

  2. Antimutagens in gaiyou (Artemisia argyi levl. et vant.).

    PubMed

    Nakasugi, T; Nakashima, M; Komai, K

    2000-08-01

    Antimutagens from gaiyou (Artemisia argyi Levl. et Vant., Compositae) were examined. The methanol extract prepared from aerial parts of this plant strongly reduced the mutagenicity of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), when Salmonella typhimurium TA98 was used in the presence of the rat liver microsomal fraction. The antimutagens were purified chromatographically while monitoring the antimutagenic activity against Trp-P-2 with a modified Ames test employing a plate method. This purification resulted in the isolation of four strong antimutagens, 5,7-dihydroxy-6,3',4'-trimethoxyflavone (eupatilin), 5, 7,4'-trihydroxy-6,3'-dimethoxyflavone (jaceosidin), 5,7, 4'-trihydroxyflavone (apigenin) and 5,7, 4'-trihydroxy-3'-methoxyflavone (chrysoeriol) from the methanol extract. These antimutagenic flavones exhibited strong antimutagenic activity against not only Trp-P-2 but also against other heterocyclic amines, such as 3-amino-1,4-dimethyl-5H-pyrido[4, 3-b]indole (Trp-P-1), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA(alpha)C) in S. typhimurium TA98. In contrast, they did not exhibit antimutagenic activity against benzo[a]pyrene (B[a]P), 4-nitroquinoline-1-oxide (4-NQO), 2-aminofluorene (2-AF), 2-nitrofluorene (2-NF) or furylfuramide (AF-2) in S. typhimurium TA98, or B[a]P, 4-NQO, 2-NF, AF-2, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or sodium azide (SA) in Salmonella typhimurium TA100, whereas they decreased the mutagenicity caused by aflatoxin B(1) (AFB(1)) and 2-aminoanthracene (2-AA) in both of these tester strains. Regarding the structure-activity relationship, the tested flavones had distinct differences in the intensities of their antimutagenic activities according to the differences of their substitution patterns. Namely, the intensity of antimutagenic activities against Trp-P-2 decreased in

  3. Amendments to (63)Ni production calculation for Hiroshima by Takamiya et al. and DS02 fluence data by Egbert et al.

    PubMed

    Takamiya, K; Imanaka, T; Egbert, S D; Rühm, W

    2011-05-01

    In a previous paper, Takamiya et al. calculated (63)Ni production in copper samples exposed to the Hiroshima atomic bomb. More specifically, they used their experimental cross-section values of the (63)Cu(n,p)(63)Ni reaction and compared the result with that of the corresponding calculation in the radiation dosimetry system DS02, which used another set of cross-section values. These results were different, and the following two reasons were found: typographical errors in several energy boundary values in the DS02 report that was also used in the calculation by Takamiya et al. and an inappropriate assumption on the cross-section values of the low neutron energy region in the calculation by Takamiya et al. These two issues are described and amended in the present report.

  4. Vulvovaginite : Dépistage et prise en charge de la trichomonase, de la candidose vulvovaginale et de la vaginose bactérienne.

    PubMed

    van Schalkwyk, Julie; Yudin, Mark H

    2016-12-01

    Analyser les données probantes et formuler des recommandations quant au dépistage et à la prise en charge de la candidose vulvovaginale, de la trichomonase et de la vaginose bactérienne. Parmi les issues évaluées, on trouve l'efficacité de l'antibiothérapie, les taux de guérison en ce qui concerne les infections simples et compliquées, et les implications de ces pathologies pendant la grossesse. RéSULTATS: La littérature publiée a été récupérée par l'intermédiaire de recherches menées dans MEDLINE, EMBASE, CINAHL et The Cochrane Library en juin 2013 au moyen d'un vocabulaire contrôlé (p. ex. « vaginitis », « trichomoniasis », « vaginal candidiasis ») et de mots clés (p. ex. « bacterial vaginosis », « yeast », « candidiasis », « trichomonas vaginalis », « trichomoniasis », « vaginitis », « treatment ») appropriés. Les résultats ont été restreints aux analyses systématiques, aux essais comparatifs randomisés / essais cliniques comparatifs et aux études observationnelles. Aucune restriction n'a été appliquée en matière de date, mais les résultats ont été limités aux documents rédigés en anglais ou en français. Les recherches ont été mises à jour de façon régulière et intégrées à la directive clinique jusqu'en mai 2014. La littérature grise (non publiée) a été identifiée par l'intermédiaire de recherches menées dans les sites Web d'organismes s'intéressant à l'évaluation des technologies dans le domaine de la santé et d'organismes connexes, dans des collections de directives cliniques et auprès de sociétés de spécialité médicale nationales et internationales. La qualité des résultats est évaluée au moyen des critères décrits par le Groupe d'étude canadien sur les soins de santé préventifs (Tableau 1). DéCLARATIONS SOMMAIRES: RECOMMANDATIONS. Copyright © 2016. Published by Elsevier Inc.

  5. Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP.

    PubMed

    Nelson, Mary L; Kang, Hyun-Seo; Lee, Gregory M; Blaszczak, Adam G; Lau, Desmond K W; McIntosh, Lawrence P; Graves, Barbara J

    2010-06-01

    Ras/MAPK signaling is often aberrantly activated in human cancers. The downstream effectors are transcription factors, including those encoded by the ETS gene family. Using cell-based assays and biophysical measurements, we have determined the mechanism by which Ras/MAPK signaling affects the function of Ets1 via phosphorylation of Thr38 and Ser41. These ERK2 phosphoacceptors lie within the unstructured N-terminal region of Ets1, immediately adjacent to the PNT domain. NMR spectroscopic analyses demonstrated that the PNT domain is a four-helix bundle (H2-H5), resembling the SAM domain, appended with two additional helices (H0-H1). Phosphorylation shifted a conformational equilibrium, displacing the dynamic helix H0 from the core bundle. The affinity of Ets1 for the TAZ1 (or CH1) domain of the coactivator CBP was enhanced 34-fold by phosphorylation, and this binding was sensitive to ionic strength. NMR-monitored titration experiments mapped the interaction surfaces of the TAZ1 domain and Ets1, the latter encompassing both the phosphoacceptors and PNT domain. Charge complementarity of these surfaces indicate that electrostatic forces act in concert with a conformational equilibrium to mediate phosphorylation effects. We conclude that the dynamic helical elements of Ets1, appended to a conserved structural core, constitute a phospho-switch that directs Ras/MAPK signaling to downstream changes in gene expression. This detailed structural and mechanistic information will guide strategies for targeting ETS proteins in human disease.

  6. Pseudotumeur cardiaque révélant une maladie de Behçet

    PubMed Central

    Nya, Fouad; Abdou, Abdessamad; Bamous, Mehdi; Moutakiallah, Younes; Atmani, Noureddine; Seghrouchni, Aniss; Houssa, Mahdi Ait; Boulahya, Abdellatif

    2017-01-01

    La thrombose intracardiaque est une complication rare de la maladie de Behçet (MB), qui peut se présenter comme une tumeur intracardiaque. Sa découverte précède, dans la moitié des cas, le diagnostic de MB. La mortalité élevée peut être en rapport avec des complications post-chirurgicales et/ou une atteinte associée des artères pulmonaires. Nous rapportons l’observation d’un jeune patient de 29 ans, aux antécédents d’aphtose bipolaire, qui a bénéficie d’une intervention chirurgicale après la découverte d’une tumeur de l’atrium et du ventricule droits. Il s’agissait d’un thrombus à l’examen anatomopathologique et dans les suites opératoires nous avons diagnostiqué une MB. L’évolution a été favorable sous traitement médical associant une corticothérapie, de la colchicine et des antivitamines K (AVK). La découverte d’une masse intracardiaque chez un sujet jeune doit faire évoquer le diagnostic de thrombus cardiaque et de maladie de Behçet, même en l’absence de facteur ethnique ou géographique prédisposant. PMID:28533874

  7. Exploring an optimal wavelet-based filter for cryo-ET imaging.

    PubMed

    Huang, Xinrui; Li, Sha; Gao, Song

    2018-02-07

    Cryo-electron tomography (cryo-ET) is one of the most advanced technologies for the in situ visualization of molecular machines by producing three-dimensional (3D) biological structures. However, cryo-ET imaging has two serious disadvantages-low dose and low image contrast-which result in high-resolution information being obscured by noise and image quality being degraded, and this causes errors in biological interpretation. The purpose of this research is to explore an optimal wavelet denoising technique to reduce noise in cryo-ET images. We perform tests using simulation data and design a filter using the optimum selected wavelet parameters (three-level decomposition, level-1 zeroed out, subband-dependent threshold, a soft-thresholding and spline-based discrete dyadic wavelet transform (DDWT)), which we call a modified wavelet shrinkage filter; this filter is suitable for noisy cryo-ET data. When testing using real cryo-ET experiment data, higher quality images and more accurate measures of a biological structure can be obtained with the modified wavelet shrinkage filter processing compared with conventional processing. Because the proposed method provides an inherent advantage when dealing with cryo-ET images, it can therefore extend the current state-of-the-art technology in assisting all aspects of cryo-ET studies: visualization, reconstruction, structural analysis, and interpretation.

  8. α -Ethyltryptamine (α-ET) As A Discriminative Stimulus in Rats†

    PubMed Central

    Glennon, Richard A.; Bondareva, Tatiana; Young, Richard

    2007-01-01

    α-Ethyltryptamine (etryptamine, α-ET) is a drug of abuse that first appeared on the clandestine market in the mid 1980s. Its pharmacological actions are poorly understood. In this investigation, it is reported for the first time that α-ET serves as a training drug in drug discrimination studies. Male Sprague-Dawley rats were trained to discriminate (30-min pretreatment time) 2.5 mg/kg of α-ET (ED50 = 1.3 mg/kg) from saline vehicle using a standard two-lever operant paradigm and a VI-15s schedule of reinforcement for appetitive reward. Once established, the α-ET stimulus was shown to have an onset to action of 30 min and a duration of effect of at least 4 hours. In tests of stimulus generalization (substitution), the α-ET stimulus generalized to S(−)α-ET (ED50 = 1.6 mg/kg) and R(+)α-ET (ED50 = 1.3 mg/kg). Tests of stimulus generalization were also conducted with prototypical phenylisopropylamines: (+)amphetamine, 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), and N-methyl-1-(4-methoxyphenyl)-2-aminopropane (PMMA). The α-ET stimulus generalized to DOM (ED50 = 0.4 mg/kg) and PMMA (ED50 = 0.7 mg/kg), but only partially generalized (ca. 40% maximal drug-appropriate responding) to (+)amphetamine. The results suggest that α-ET produces a complex stimulus. PMID:17112572

  9. Role of trehalose in heat and desiccation tolerance in the soil bacterium Rhizobium etli

    PubMed Central

    2012-01-01

    Background The compatible solute trehalose is involved in the osmostress response of Rhizobium etli, the microsymbiont of Phaseolus vulgaris. In this work, we reconstructed trehalose metabolism in R. etli, and investigated its role in cellular adaptation and survival to heat and desiccation stress under free living conditions. Results Besides trehalose as major compatible solute, R. etli CE3 also accumulated glutamate and, if present in the medium, mannitol. Putative genes for trehalose synthesis (otsAB/treS/treZY), uptake (aglEFGK/thuEFGK) and degradation (thuAB/treC) were scattered among the chromosome and plasmids p42a, p42c, p42e, and p42f, and in some instances found redundant. Two copies of the otsA gene, encoding trehalose-6-P-synthase, were located in the chromosome (otsAch) and plasmid p42a (otsAa), and the latter seemed to be acquired by horizontal transfer. High temperature alone did not influence growth of R. etli, but a combination of high temperature and osmotic stress was more deleterious for growth than osmotic stress alone. Although high temperature induced some trehalose synthesis by R. etli, trehalose biosynthesis was mainly triggered by osmotic stress. However, an otsAch mutant, unable to synthesize trehalose in minimal medium, showed impaired growth at high temperature, suggesting that trehalose plays a role in thermoprotection of R. etli. Desiccation tolerance by R. etli wild type cells was dependent of high trehalose production by osmotic pre-conditioned cells. Cells of the mutant strain otsAch showed ca. 3-fold lower survival levels than the wild type strain after drying, and a null viability after 4 days storage. Conclusions Our findings suggest a beneficial effect of osmotic stress in R. etli tolerance to desiccation, and an important role of trehalose on the response of R. etli to high temperature and desiccation stress. PMID:22985230

  10. Pharmacologic studies on ET-26 hydrochloride in a rat model of lipopolysaccharide-induced sepsis.

    PubMed

    Wang, Bin; Jiang, Junli; Yang, Jun; Chen, Jun; Zhu, Zhaoqiong; Liu, Jin; Zhang, Wensheng

    2017-11-15

    ET-26 hydrochloride (ET-26 HCl) is a promising sedation-hypnotic compound with stable hemodynamic features that elicits virtually no adrenocortical suppression. However, whether it preserves better pharmacologic characteristics in a rat model of sepsis is not known. This study compared the survival rate, levels of corticosterone and pro-inflammatory cytokines, and histologic injury in the lungs and kidneys of rats suffering from sepsis treated with ET-26 HCl, etomidate, or normal saline (NS). Rats were given lipopolysaccharide (1mg/kg body weight, i.v.) to establish a sepsis model. Thirty minutes after lipopolysaccharide administration, ET-26 HCl, etomidate or NS were given as a bolus injection at equivalent doses. Plasma levels of corticosterone, interleukin-1β, interleukin-6, interleukin-10, and tumor necrosis factor-α were measured 1, 2, 4, 6 and 24h after administration. Histologic injury was observed at the time of death or 24h after drug administration. The survival rate for rats in the etomidate, ET-26 HCl and NS groups was 40%, 90% and 90%, respectively. Corticosterone concentrations in the etomidate group were lower than those in the other groups 1h after administration of hypnotic compounds. Concentrations of pro-inflammatory cytokines in the ET-26 HCl group and NS group were not significantly different, but were significantly lower than those in the etomidate group. The injury scores of kidneys and lungs in the etomidate group were higher than those in ET-26 HCl and NS groups. ET-26 HCl showed virtually no suppression of corticosterone synthesis, lower concentrations of pro-inflammatory cytokines, higher survival rate, and less organ injury in rats suffering from sepsis compared with the etomidate group. It may be safer to induce anesthesia using ET-26 HCl, rather than etomidate, in patients suffering from sepsis. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Elevated endothelin-1 (ET-1) levels may contribute to hypoadiponectinemia in childhood obesity.

    PubMed

    Nacci, Carmela; Leo, Valentina; De Benedictis, Leonarda; Carratù, Maria Rosaria; Bartolomeo, Nicola; Altomare, Maria; Giordano, Paola; Faienza, Maria Felicia; Montagnani, Monica

    2013-04-01

    Pediatric obesity is associated with endothelial dysfunction and hypoadiponectinemia, but the relationship between these two conditions remains to be fully clarified. Whether enhanced release of endothelin-1 (ET-1) may directly impair adiponectin (Ad) production in obese children is not known. The aim of the study was to explore whether and how high circulating levels of ET-1 may contribute to impair Ad production, release, and vascular activity. Sixty children were included into obese (Ob; n = 30), overweight (OW; n = 11), and lean (n = 19) groups. Total and high-molecular-weight Ad, ET-1, vascular cell adhesion molecule-1, and von Willebrand factor levels were measured in serum samples. Adipocytes were stimulated with exogenous ET-1 or with sera from lean, OW, and Ob, and Ad production and release measured in the absence or in the presence of ETA (BQ-123) and ETB (BQ-788) receptor blockers, p42/44 MAPK inhibitor PD-98059, or c-Jun NH2-terminal protein kinase inhibitor SP-600125. Vasodilation to Ad was evaluated in rat isolated arteries in the absence or in the presence of BQ-123/788. Total and high-molecular-weight Ad was significantly decreased and ET-1 levels significantly increased in OW (P < .01) and Ob (P < .001) children. A statistically significant linear regression (P < .01) was found between Ad and ET-1. Exposure of adipocytes to exogenous ET-1 or serum from OW and Ob significantly decreased Ad mRNA and protein levels (P < 0.001). The inhibitory effect of ET-1 on Ad was reverted by BQ-123/788 or PD-98059 but not SP-600125. Ad-mediated vasodilation was further increased in arteries pretreated with BQ-123/788. ET-1-mediated inhibition of Ad synthesis via p42/44 MAPK signaling may provide a possible explanation for hypoadiponectinemia in pediatric obesity and contribute to the development of cardiovascular complications.

  12. Author's Rebuttal to Smits et al. (2018), "Comment on 'Sensitivity of the Speech Intelligibility Index to the Assumed Dynamic Range' by Jin et al. (2017)".

    PubMed

    Jin, In-Ki; Kates, James M; Arehart, Kathryn H

    2018-01-22

    The purpose of this letter is to refute the comments written by Smits, Goverts, and Versfeld (2018). Refutations to each issue including the fixed mathematical relationship between dynamic range (DR) and a fitting constant (Q value), deviating results for small DRs, and determination of Speech Intelligibility Index (SII) model parameters are described. Although Smits et al. (2018) correctly identified several issues, those comments do not diminish the results of the original article (Jin, Kates, & Arehart, 2017) in providing new insights for the SII. Jin et al. (2017) clearly provided the impact of languages and DR on the SII, which was the main result of the study.

  13. Command and Control (C2) Agility (Agilite du commandement et du controle (C2))

    DTIC Science & Technology

    2014-10-01

    de la rigueur et de l’emploi des méthodes de mesure et d’amélioration de l’agilité du C2. Le spectre des missions... Control and Intelligence (C2I) Section DRDC Valcartier 2459 de la Bravoure Road Québec (Québec) G3J 1X5 CANADA Email: Micheline.Belanger@drdc...Agilité du commandement et du contrôle (C2) (STO-TR-SAS-085) Synthèse L’agilité est la capacité à effectuer avec succès, s’occuper de

  14. Corrosion and Maintenance Data Sharing (Partage des Donnees de Corrosion et de Maintenance)

    DTIC Science & Technology

    2011-11-01

    la gestion des flottes vieillissantes. Les actions correctives sont généralement considérées comme étant du domaine...conception et la sélection des matériaux adaptés et ont joué un rôle fondamental dans la gestion de la production et la livraison des nouveaux avions. Le même...selon le cas, suivi du numéro de série. Des informations analogues, telles que le titre est la date de publication sont

  15. Etude descriptive et analytique du cancer de l’œsophage au Togo

    PubMed Central

    Oumboma, Bouglouga; Mawuli, Lawson-Ananissoh Laté; Aklesso, Bagny; Laconi, Kaaga; Datouda, Redah

    2014-01-01

    Introduction Décrire les aspects épidémiologiques, cliniques, endoscopiques et histologiques du cancer de l’œsophage (CO) au Togo. Méthodes Il s'agit d'une étude rétrospective descriptive et analytique menée sur 8 ans (Janvier 2005-Décembre 2012) dans le service d'hépato-gastroentérologie (HGE) du CHU Campus de Lomé. Etaient inclus les dossiers des patients hospitalisés pour CO confirmé histologiquement. Résultats Sur 8 ans, 24 patients remplissant nos critères d'inclusion ont été retenus soit 3cas de CO par an et 0,55% des hospitalisations. L’âge moyen des patients était de 57,08 ans (extrêmes: 32 et 82 ans). La dysphagie et l’épigastralgie étaient les motifs d'hospitalisation les plus rencontrés. L'alcool (n=15), le tabac (n=13) étaient les facteurs de risque les plus présents. A la fibroscopie, les lésions étaient ulcéro-bourgeonnantes et hémorragiques (n=12), ulcéro-bourgeonnantes (n=5); ces lésions siégeaient au niveau du 1/3 inférieur (n= 11), à l'union 1/3 supérieur 1/3moyen de l’œsophage (n= 13) et aucun au niveau du 1/3 supérieur. Seize lésions étaient des carcinomes épidermoïdes et 3 des adénocarcinomes. L’évolution dans le service a été fatale dans 2cas; 16 patients avaient été transférés en chirurgie pour des soins palliatifs et 5 patients (20,8%) étaient perdus de vue. Conclusion Le CO semble en augmentation au Togo. L'alcool et le tabac sont les facteurs de risque et le pronostic sévère dans notre série est lié au retard diagnostic. Son dépistage précoce passe par une consultation rapide devant toute dysphagie chez un sujet de 50 ans et plus. PMID:25883742

  16. Spectroscopie du Furanne et du Thiophene Par Diffusion Inelastique D'electrons

    NASA Astrophysics Data System (ADS)

    Lotfi, Said

    Nous avons etudie les molecules de furanne ( rm C_4H_4O) et de thiophene (rm C_4H_4O) au moyen de la spectroscopie de diffusion inelastique d'electrons. Pour (rm C_4H_4O), les spectres realises dans differentes conditions d'energie d'impact et d'angle de diffusion contiennent des singularites ou des families de pics correspondant a: (1) des vibrations de l'etat fondamental dans le domaine 0-0.5 eV, (2) des etats triplets ^3 B_1 et ^3 A_1 qui dominent la region 3-5.5 eV, (3) des etats de valences, entre 5 et 10 eV, dont certains son accompagnes de progressions vibrationnelles, soit ~ A _1B_2, ~ B ^1A_1 et ~ C ^1A_1, (4) toujours entre 5 et 10 eV, deux series de Ryhdberg (rm 1a_2to nda_2 et rm 1a_2to npb_2) qui convergent vers la premiere limite d'ionisation de la molecule, avec une progression vibrationnelle associee au mdoe nu_4 pour la seconde, et une troisieme serie (rm 2b_1to nsa_1 ) convergent vers la seconde limite d'ionisation accompagnee de la progression de mode nu _1. Pour rm C_4H_4S, nos spectres presentent les memes etats de vibration et les memes etats triplets que pour rm C_4H _4O. Nous avons releve egalement, dans la region de 5 a 10 eV, des etats de valence ~ A ^1A_1 (ou ~ A ^1B_2), ~ B ^1A_1 (ou ~ B ^1B _2) et ~ C ^1A_1 (ou ~ C ^1B_2). Pour la premiere fois, par la spectroscopie de diffusion inelastique d'electrons, de nombreux pics ont ete identifies et attribues, dans le cadre de ce travail. Il s'agit, notamment, des etats de vibration de l'etat electronique fondamental de ces molecules et egalement de certains etats de Rydberg dans le cas du furanne.

  17. Behçet's Disease and Intracardiac Thrombosis: A Report of Three Cases

    PubMed Central

    Düzgün, Nurşen; Küçükşahin, Orhan; Atasoy, Kayhan Çetin; Togay Işıkay, Canan; Gerede, Demet Menekşe; Erden, Ayşe; Şahap, Seda Kaynak; İbiş, Muhammed Arif; Ateş, Aşkın

    2013-01-01

    We present three patients with Behçet's disease associated with intracardiac thrombus and pulmonary vascular involvement. One of these patients had also Budd-Chiari syndrome. All patients were treated with corticosteroid plus monthly intravenous cyclophosphamide as first line treatment and with no recurrences. Immunosuppressive therapy was successful in the treatment of intracardiac thrombus and also in the regression of pulmonary vascular thromboses in these patients. Intracardiac thrombus in Behçet's disease is rarely seen. Behçet's disease should be remembered in the differential diagnosis of the patients with intracardiac mass, especially in patients from the Mediterranean and Middle East populations. PMID:23936717

  18. Behçet's disease with endocarditis and the Budd-Chiari syndrome.

    PubMed Central

    McDonald, G S; Gad-Al-Rab, J

    1980-01-01

    Endocarditis of the mitral and aortic valves is described for the first time in a patient with Behçet's disease. A second patient had minor changes in the mitral valve similar to that seen in the vasculitis which occurs in this condition. Valvulitis in Behçet's disease probably has the same pathogenesis as the vasculitis. The second patient also had a rare combination of Behçet's disease and the Budd-Chiari syndrome, and the necropsy findings are described. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 PMID:7430372

  19. Specific brainstem and cortico-spinal reflex abnormalities in coexisting essential tremor and Parkinson's disease (ET-PD).

    PubMed

    Yavuz, D; Gündüz, A; Ertan, S; Apaydın, H; Şifoğlu, A; Kiziltan, G; Kiziltan, M E

    2015-05-01

    We aimed to analyze functional changes at brainstem and spinal levels in essential tremor (ET), Parkinson's disease (PD) and coexisting essential tremor and Parkinson's disease (ET-PD). Age- and gender-matched patients with tremor (15 ET, 7 ET with resting tremor, 25 ET-PD and 10 PD) and 12 healthy subjects were enrolled in the study. Diagnosis was established according to standardized clinical criteria. Electrophysiological studies included blink reflex (BR), auditory startle reaction (ASR) and long latency reflex (LLR). Blink reflex was normal and similar in all groups. Probability of ASR was significantly lower in ET-PD group whereas it was similar to healthy subjects in ET and PD (P<0.001). LLR was recorded during voluntary activity in all three groups. LLR II was more common in ET, PD and ET-PD groups. LLR III was far more common in the PD group (n=3, 13.6% in ET; n=4, 16.0% in ET-PD and n=7, 46.7% in PD; p=0.037). Despite the integrity of BR pathways, ASR and LLR show distinctive abnormalities in ET-PD. In our opinion, our electrophysiological findings support the hypothesis that ET-PD is a distinct entity. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  20. ET-26 hydrochloride (ET-26 HCl) has similar hemodynamic stability to that of etomidate in normal and uncontrolled hemorrhagic shock (UHS) rats.

    PubMed

    Wang, Bin; Chen, Shouming; Yang, Jun; Yang, Linghui; Liu, Jin; Zhang, Wensheng

    2017-01-01

    ET-26 HCl is a promising sedative-hypnotic anesthetic with virtually no effect on adrenocortical steroid synthesis. However, whether or not ET-26 HCl also has a sufficiently wide safety margin and hemodynamic stability similar to that of etomidate and related compounds remains unknown. In this study, the effects of ET-26 HCl, etomidate and propofol on therapeutic index, heart rate (HR), mean arterial pressure (MAP), maximal rate for left ventricular pressure rise (Dmax/t), and maximal rate for left ventricular pressure decline (Dmin/t) were investigated in healthy rats and a rat model of uncontrolled hemorrhagic shock (UHS). 50% effective dose (ED50) and 50% lethal dose (LD50) were determined after single bolus doses of propofol, etomidate, or ET-26 HCl using the Bliss method and the up and down method, respectively. All rats were divided into either the normal group and received either etomidate, ET-26 HCl or propofol, (n = 6 per group) or the UHS group and received either etomidate, ET-26 HCl or propofol, (n = 6 per group). In the normal group, after preparation for hemodynamic and heart-function monitoring, rats were administered a dose of one of the test agents twofold-higher than the established ED50, followed by hemodynamic and heart-function monitoring. Rats in the UHS group underwent experimentally induced UHS with a target arterial pressure of 40 mmHg for 1 hour, followed by administration of an ED50 dose of one of the experimental agents. Blood-gas analysis was conducted on samples obtained during equilibration with the experimental setup and at the end of the experiment. In the normal group, no significant differences in HR, MAP, Dmax/t and Dmin/t (all P > 0.05) were observed at any time point between the etomidate and ET-26 HCl groups, whereas HR, MAP and Dmax/t decreased briefly and Dmin/t increased following propofol administration. In the UHS group, no significant differences in HR, MAP, Dmax/t and Dmin/t were observed before and after administration

  1. Automated Software Generation Approaches for the Design and Development of Guidance and Control Systems Software (Les Differentes Approches Generation pour la Conception et le Developpement de Logiciels de Guidage et de Pilotage)

    DTIC Science & Technology

    1992-03-01

    de Logiciels") etaient en cours de developpement pour resoudre des problimes similaires dans le monde de la gestion . le Panel... gestion des sp cifications, d’algorithmes et de reprtsentations. Techniques et Sciences Informatiques, 4(3), 1985. 4-21 R. Jacquart, M. Lemoine, and G...Guidance and Control Systems Software (Les Diff~rentes Approches "G6neration" pour la Conception et le D~veloppement de Logiciels de Guidage et de

  2. NASA Land Information System (LIS) Water Availability to Support Reclamation ET Estimation

    NASA Technical Reports Server (NTRS)

    Toll, David; Arsenault, Kristi; Pinheiro, Ana; Peters-Lidard, Christa; Houser, Paul; Kumar, Sujay; Engman, Ted; Nigro, Joe; Triggs, Jonathan

    2005-01-01

    The U.S. Bureau of Reclamation identified the remote sensing of evapotranspiration (ET) as an important water flux for study and designated a test site in the Lower Colorado River basin. A consortium of groups will work together with the goal to develop more accurate and cost effective techniques using the enhanced spatial and temporal coverage afforded by remote sensing. ET is a critical water loss flux where improved estimation should lead to better management of Reclamation responsibilities. There are several areas where NASA satellite and modeling data may be useful to meet Reclamation's objectives for improved ET estimation. In this paper we outline one possible contribution to use NASA's data integration capability of the Land Information System (LIS) to provide a merger of observational (in situ and satellite) with physical process models to provide estimates of ET and other water availability outputs (e.g., runoff, soil moisture) retrospectively, in near real-time, and also providing short-term predictions.

  3. Behçet disease and protein-losing enteropathy due to intestinal lymphangiectasia.

    PubMed

    Rodríguez-Muguruza, Samantha; Caballero, Noemí; Horneros, Judith; Domenech, Eugeni; Mateo, Lourdes

    2015-01-01

    We report an unusual case of a patient with Behçet's disease that developed protein-losing enteropathy due to intestinal lymphangiectasia. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

  4. 41 CFR 301-73.101 - How must we prepare to implement ETS?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... traveler use of your online self-service booking tool once you have fully deployed ETS within your agency... applicable business systems (e.g., financial, human resources, etc.). Note 2 to § 301-73.101: Best practices...

  5. Competitive adsorption of Pb2+, Cu2+, and Cd2+ ions on microporous titanosilicate ETS-10.

    PubMed

    Lv, Lu; Hor, Mei Peng; Su, Fabing; Zhao, X S

    2005-07-01

    In the present study, the competitive adsorption characteristics of binary and ternary heavy metal ions Pb2+, Cu2+, and Cd2+ on microporous titanosilicate ETS-10 were investigated in batch systems. Pure microporous titanosilicate ETS-10 was synthesized with P25 as the Ti source and characterized by the techniques of X-ray diffraction (XRD), field emission-scanning electron microscope (FESEM), nitrogen adsorption, and zeta-potential. Equilibrium and kinetic adsorption data showed that ETS-10 displays a high selectivity toward one metal in a two-component or a three-component system with an affinity order of Pb2+ > Cd2+ > Cu2+. The equilibrium behaviors of heavy metals species with stronger affinity toward ETS-10 can be described by the Langmuir equation while the adsorption kinetics of the metals can be well fitted to a pseudo-second-order (PSO) model.

  6. XPS characterization of silver exchanged ETS-10 and mordenite molecular sieves.

    PubMed

    Anson, A; Maham, Y; Lin, C C H; Kuznicki, T M; Kuznicki, S M

    2009-05-01

    Silver exchanged molecular sieves ETS-10 (Ag-ETS-10) and mordenite (Ag-mordenite) were dehydrated under vacuum at temperatures between 100 degrees C-350 degrees C. Changes in the state of the silver were studied using X-ray photoelectron spectroscopy (XPS). Silver cations in titanosilicate Ag-ETS-10 are fully reduced to Ag(0) at temperatures as low as 150 degrees C. The characteristic features of the XPS spectrum of silver in this Ag-ETS-10 species correspond to only metallic silver. The signal for metallic silver is not observed in the XPS spectrum of aluminosilicate Ag-mordenite, indicating that silver cations are not reduced, even after heating to 350 degrees C.

  7. Design and development status of ETS-7, an RVD and space robot experiment satellite

    NASA Technical Reports Server (NTRS)

    Oda, M.; Inagaki, T.; Nishida, M.; Kibe, K.; Yamagata, F.

    1994-01-01

    ETS-7 (Engineering Test Satellite #7) is an experimental satellite for the in-orbit experiment of the Rendezvous Docking (RVD) and the space robot (RBT) technologies. ETS-7 is a set of two satellites, a chaser satellite and a target satellite. Both satellites will be launched together by NASDA's H-2 rocket into a low earth orbit. Development of ETS-7 started in 1990. Basic design and EM (Engineering Model) development are in progress now in 1994. The satellite will be launched in mid 1997 and the above in-orbit experiments will be conducted for 1.5 years. Design of ETS-7 RBT experiment system and development status are described in this paper.

  8. Identification of multiple nuclear localization signals in murine Elf3, an ETS transcription factor.

    PubMed

    Do, Hyun-Jin; Song, Hyuk; Yang, Heung-Mo; Kim, Dong-Ku; Kim, Nam-Hyung; Kim, Jin-Hoi; Cha, Kwang-Yul; Chung, Hyung-Min; Kim, Jae-Hwan

    2006-03-20

    We investigated nuclear localization signal (NLS) determinants within the AT-hook and ETS DNA-binding domains of murine Elf3 (mElf3), a member of the subfamily of epithelium-specific ETS transcription factors. Deletion mutants containing the AT-hook, ETS domain or both localized strictly in the nucleus, suggesting that these individual domains contain independent NLS motif(s). Within the AT-hook domain, four basic residues (244KRKR247) were critical for strong NLS activity, and two potent bipartite NLS motifs (236-252 and 249-267) were sufficient for nuclear import of mElf3, although less efficient than the full domain. In addition, one stretch of basic residues (318KKK320) within the ETS domain appears to be essential for mElf3 nuclear localization. Taken together, mElf3 contains multiple NLS motifs, which may function cooperatively to effect efficient nuclear transport.

  9. Problemes et methodes de la lexicographie quebecoise (Problems and Methods of Quebec Lexicography).

    ERIC Educational Resources Information Center

    Cormier, Monique C., Ed.; Francoeur, Aline, Ed.

    Papers on lexicographic research in Quebec (Canada) include: "Indications semantiques dans les dictionnaires bilingues" ("Semantic Indications in Bilingual Dictionaries) (Johanne Blais, Roda P. Roberts); "Definitions predictionnairiques de 'maison, batiment, et pavillon'" ("Pre-dictionary definitions of 'house,…

  10. 75 FR 61786 - Northern Lights Fund Trust, et al.; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ...] Northern Lights Fund Trust, et al.; Notice of Application September 30, 2010. AGENCY: Securities and... certain financial instruments. Applicants: Northern Lights Fund Trust (``NLFT''), Arrow Investment Advisors, LLC (``AIA''), and Northern Lights Distributors, LLC (``NLD''). Filing Dates: The application was...

  11. 77 FR 66609 - Notice of FERC Staff Attendance; PacifiCorp, et al.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ...-82-000 El Paso Electric Company ER13-91-000 Black Hills Power, Inc., et al......... ER13-96-000 Black... Commission's ongoing outreach efforts. The meeting may discuss matters at issue in the above captioned...

  12. Quelques considerations sur la traduction medicale et pharmaceutique (Some Considerations in Medical and Pharmaceutical Translation)

    ERIC Educational Resources Information Center

    Sliosberg, A.

    1971-01-01

    Paper presented during the meeting of the Section Presse et Documentation" of the 29th International Congress of Pharmaceutical Science of the International Pharmaceutical Federation, London, September 10, 1969. (VM)

  13. Complete Genome Sequence of Campylobacter iguaniorum Strain 1485ET, Isolated from a Bearded Dragon (Pogona vitticeps).

    PubMed

    Gilbert, Maarten J; Miller, William G; Yee, Emma; Kik, Marja; Wagenaar, Jaap A; Duim, Birgitta

    2014-08-21

    Campylobacter iguaniorum has been isolated from reptiles. This Campylobacter species is genetically related to Campylobacter fetus and Campylobacter hyointestinalis. Here we present the first whole-genome sequence for this species. Copyright © 2014 Gilbert et al.

  14. 75 FR 43918 - National Center for Toxicological Research, et al.; Notice of Consolidated Decision on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... Research, et al.; Notice of Consolidated Decision on Applications for Duty-Free Entry of Electron...: National Center for Toxicological Research, (USFDA), Jefferson, AK 72079. Instrument: Electron Microscope.... Applicant: University of Virginia, Charlottesville, VA 22903. Instrument: Electron Microscope. Manufacturer...

  15. Synthesis of Self-Bonded Pellets of ETS-4 Phase by New Methodology of Preparation

    NASA Astrophysics Data System (ADS)

    De Luca, P.; Mastroianni, C.; Nagy, J. B.

    2018-06-01

    We hereby present the results of a research in order to prepare self-bonded pellets of ETS-4 phase by a new methodology of preparation. In particular, the pellets were prepared by kneading crystals of ETS-4 phase and a dry gel, the latter being the precursor for the synthesis of the ETS-4 phase crystals. One of the innovative aspects that is proposed and highlighted in this work is represented by the fact that the dry-gel acts as a “binder”. It is characterized by the same chemical composition of crystals, thus avoiding contamination with other elements. In addition, dry-gel allows, the promotion of nucleation phenomena and thus the formation of new crystals of ETS-4 during the pellets baking phases. The pellets were characterized by X-ray diffraction (XRD), Electron microscopy (SEM) and mechanical strength by hardness tester.

  16. Mise en oeuvre et caracterisation de pieces autotrempantes elaborees avec de nouveaux alliages meres

    NASA Astrophysics Data System (ADS)

    Bouchemit, Arslane Abdelkader

    : L'autotrempabilite des aciers en metallurgie des poudres (MP) permet d'obtenir des pieces ayant une microstructure de trempe (martensite et/ou bainite), et ce, directement lors du refroidissement a la sortie du four de frittage (frittage industriel : 10 45 °C/min [550 a 350 °C]). Cela permet entre autres d'eliminer les traitements thermiques d'austenisation et de trempe (a l'eau : ≈ 2700 °C/min ou a l'huile : ≈ 1100 °C/min [550 a 350 °C] [17]) generalement requis apres le frittage afin d'obtenir une microstructure martensitique. Ainsi, le procede de fabrication est simplifie, moins couteux et la distorsion des pieces due au refroidissement rapide lors de la trempe est evitee. De plus, l'utilisation des bains d'huile est eliminee ce qui rend le procede plus securitaire et ecologique. Les principaux parametres commandant l'autotrempabilite sont : le taux de refroidissement et la composition chimique de l'acier. De nos jours, les systemes de refroidissement a convection forcee combines aux fours industriels permettent d'obtenir des taux de refroidissement eleves a la sortie des fours (60 300 °C/min [550 a 350 °C]) [18, 19]. De plus, le taux de refroidissement critique induisant la formation de la structure de trempe est largement influence par la composition chimique de l'acier. Ainsi, plus l'acier est allie (jusqu'a une certaine limite), plus ce taux de refroidissement critique est moindre. Le molybdene, le nickel et le cuivre sont les elements usuellement utilises en MP. Cependant, le manganese et le chrome sont moins couteux et ont un impact plus marque sur l'autotrempabilite, malgre cela, ils sont rarement utilises a cause de leur susceptibilite a l'oxydation et la degradation de la compressibilite causee par le manganese. L'objectif principal de ce projet est de developper des melanges autotrempants en ajoutant des alliages meres (MA : MA1, MA2 et MA4) fortement allies au manganese (5 15 %m) et au chrome (5 15 %m) qui contiennent beaucoup de carbone

  17. 41 CFR 301-73.101 - How must we prepare to implement ETS?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... traveler use of your online self-service booking tool once you have fully deployed ETS within your agency... applicable business systems (e.g., financial, human resources, etc.). Note 2 to § 301-73.101: Best practices...

  18. Protecting the Children: Huckleberry Finn, E.T. and the Politics of Censorship.

    ERIC Educational Resources Information Center

    Magistrale, Anthony

    1984-01-01

    Explicates core aspects of two censored narratives: the movie "E.T.: The Extraterrestrial" and the novel "Huckleberry Finn." Points out similarities between the two works and raises the issue of the estrangement of youth from adult society. (RH)

  19. Two-source energy balance model to calculate row crop E.T. and ET:Advances at ARS, Bushland, TX 2010-2015

    The two-source energy balance (TSEB) model has undergone several advances recently that improved its accuracy in calculating evaporation (E), transpiration (T), and evapotranspiration (ET) for row crops. These advances were tested using microlysimeter, sap flow, and large weighing lysimeter measurem...

  20. Reply to the commentary by Hillman et al. on: "Vascular distensibilities have minor effects on intracardiac shunt patterns in reptiles" by Filogonio et al. (2017).

    PubMed

    Filogonio, Renato; Costa Leite, Cléo Alcantara; Wang, Tobias

    2017-06-01

    Our meta-analysis (Filogonio et al., 2017) on central vascular blood flows in a snake (Crotalus durissus) and a turtle (Trachemys scripta) was motivated by Hillman et al.'s (2014) analysis on amphibians to investigate whether cardiac shunt patterns depend on cardiac output and vascular distensibilities. In contrast to Hillman et al. (2014), we did not uncover a general trend that supports the notion that cardiac shunts in reptiles are dictated by vascular distensibilities. In addition to our response to the criticism raised by Hillman et al. (2017), we suggest that future experiments should consider (i) both compliance and distensibility of the major arteries; (ii) differences in volume of the systemic and pulmonary circuits to account for the accommodation of stroke volume; and (iii) an evaluation of the pulsatile pressures in both the ventricle and the major arteries to consider the timing of the ventricular ejection provided by opening of the ventricular valves. We hope these suggestions may help future clarification of the relative importance of passive arterial mechanical properties compared to autonomic regulation in determining intracardiac shunts in both amphibians and reptiles. Copyright © 2017 Elsevier GmbH. All rights reserved.

  1. ETS Matched Pictures Language Comprehension Task I and II; Technical Report 5. Disadvantaged Children and Their First School Experiences. ETS-Head Start Longitudinal Study. Technical Report Series.

    ERIC Educational Resources Information Center

    Meissner, Judith A.; And Others

    The ETS Matched Pictures test was used in the longitudinal study to measure children's comprehension of certain grammatical features, such as past and future tenses, negation and prepositions. The task materials for both I and II consist of a set of cards, with each card having a pair of black and white pictures. Both pictures in a pair contain…

  2. A Review of ETS Differential Item Functioning Assessment Procedures: Flagging Rules, Minimum Sample Size Requirements, and Criterion Refinement. Research Report. ETS RR-12-08

    ERIC Educational Resources Information Center

    Zwick, Rebecca

    2012-01-01

    Differential item functioning (DIF) analysis is a key component in the evaluation of the fairness and validity of educational tests. The goal of this project was to review the status of ETS DIF analysis procedures, focusing on three aspects: (a) the nature and stringency of the statistical rules used to flag items, (b) the minimum sample size…

  3. Recent gravity monitoring of ETS transient deformation in the northern Cascadia Subduction Zone

    NASA Astrophysics Data System (ADS)

    Henton, J. A.; Dragert, H.; Lambert, A.; Nykolaishen, L.; Liard, J.; Courtier, N.

    2012-12-01

    High-precision gravity observations are sensitive to vertical motion of the observation site as well as mass redistribution and can be used to investigate the physical processes involved in Episodic Tremor and Slip (ETS). For the 2011 ETS event in the northern portion of the Cascadia Subduction Zone, absolute gravity (AG) observations and continuous gravity monitoring with an earth tide (ET) gravimeter were carried out at the Pacific Geoscience Centre (PGC) in order to augment the GPS and borehole strainmeter (BSM) data used in constraining models of slip on the subduction plate interface. Unfortunately, the surface displacements and strains for the August 2011 slow slip event were significantly less for southern Vancouver Island than those recorded for previous events making this particular ETS episode less than ideal for the search for attendant gravity signals. Nonetheless, preliminary AG results for the 2011 ETS event show a subtle (≤ 1μGal) negative transient gravity signal but its origin is not clear. This residual gravity change, after accounting for the gravity offset predicted from the observed height change, may reflect a migration of fluids and/or a change in mean density. No significant vertical change is observed in the GPS data. Based on previous events, this is expected since PGC lies close to the hinge-line for vertical deformation for regional ETS. We attempt to improve the resolution of the GPS results by including results from NRCan's PPP software in our analyses. Data from the 3 co-located BSM's operated by the Plate Boundary Observatory show discrepancies that indicate interfering signals of likely non-tectonic origin. Preliminary data from the ET gravimeter appear to be dominated by non-linear instrumental drift that is often observed at the outset of continuous operation at a new location. To improve the resolution of the gravity signal, future monitoring of ETS events will be supplemented at PGC by continuous gravity measurements with a

  4. [Research on compatibility of prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung based on complex network analysis].

    PubMed

    Li, Meng-Wen; Fan, Xin-Sheng; Zhang, Ling-Shan; Wang, Cong-Jun

    2017-09-01

    The applications of prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung in contemporary literatures from 1949 to 2016 are compiled and the data mining techniques containing scale-free complex network method are utilized to explore its practical characteristics, with comparison between modern and ancient ones. The results indicate that malignant neoplasms, coronary heart disease which present Qi deficiency and blood stasis type are the main diseases treated by prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung according to the reports during 1949 to 2016. The complex network connection shows that Glycyrrhizae Radixet Rhizoma, Angelicae Sinensis Radix, Astragali Radix, Typhae Pollen, Salviae Miltiorrhizae Radix et Rhizoma are the primary drugs related to Ginseng Radix et Rhizoma and Trogopterus Dung. The next are Paeoniae Radix Alba, Atractylodis Macrocephalae Rhizoma, Persicae Semen, Foria, et al. Carthami Flos, Notoginseng Radix et Rhizoma, Cyperi Rhizoma, Bupleuri Radix are the peripheral ones. Also, Ginseng Radix et Rhizoma-Glycyrrhizae Radixet Rhizoma, Trogopterus Dung-Glycyrrhizae Radixet Rhizoma, Ginseng Radix et Rhizoma-Angelicae Sinensis Radix, Trogopterus Dung-Angelicae Sinensis Radix, Ginseng Radix et Rhizoma-Astragali Radix, Trogopterus Dung-Astragali Radix are the main paired drugs. The paired drugs including Ginseng Radix et Rhizoma-Trogopterus Dung-Glycyrrhizae Radixet Rhizoma, Ginseng Radix et Rhizoma-Trogopterus Dung-Angelicae Sinensis Radix, Ginseng Radix et Rhizoma-Trogopterus Dung-Astragali Radix, Ginseng Radix et Rhizoma-Trogopterus Dung-Typhae Pollen have a higher support degree. The main compatible drugs are different in ancient and modern prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung. Notoginseng Radix et Rhizoma, Typhae Pollen, Salviae Miltiorrhizae Radix et Rhizoma, Astragali Radix are utilized frequently in modern prescriptions while less used in ancient ones. It is also shown

  5. Double pylorus in a patient with Behçet's syndrome.

    PubMed

    Hatemi, Ibrahim; Hatemi, Gulen; Erzin, Yusuf Z; Celik, Aykut Ferhat

    2015-01-01

    We report a patient with Behçet's syndrome who presented with upper gastrointestinal haemorrhage. Gastroduodenoscopy showed a gastroduodenal fistula which caused the appearance of double pylorus in the antrum. The possibility of peptic ulcer disease related to non-steroidal anti-inflammatory drug use or Behçet's syndrome itself, as the cause of this rare condition in this patient is discussed.

  6. Piracetam inhibits ethanol (EtOH)-induced memory deficit by mediating multiple pathways.

    PubMed

    Yang, Yifan; Feng, Jian; Xu, Fangyuan; Wang, Jianglin

    2017-12-01

    Excessive ethanol (EtOH) intake, especially to prenatal exposure, can significantly affect cognitive function and cause permanent learning and memory injures in children. As a result, how to protect children from EtOH neurotoxicity has gained increasing attention in recent years. Piracetam (Pir) is a nootropic drug derived from c-aminobutyric acid and can manage cognition impairments in multiple neurological disorders. Studies have shown that Pir can exert therapeutic effects on EtOH-induced memory impairments, but the underlying mechanism is still unknown. In this study, we found that Pir inhibited ethanol-induced memory deficit by mediating multiple pathways. Treatment with EtOH could cause cognitive deficit in juvenile rats, and triggered the alteration of synaptic plasticity. Administration with Pir significantly increased long-term potentiation and protected hippocampus neurons from EtOH neurotoxicity. Pir intervention ameliorated EtOH-induced cell apoptosis and inhibited the activation of Caspase-3 in vitro, suggesting that Pir protected neurons by anti-apoptotic effects. Pir could decrease the expression of LC3-II and Beclin-1 induced by EtOH, and increase the phosphorylation of mTOR and reduce the phosphorylation of Akt, which suggested that the protective effect of Pir was involved in regulation of autophagic process and mTOR/Akt pathways. In conclusion, we speculate that Pir reduces EtOH-induced neuronal damage by regulation of apoptotic action and autophagic action, and our research offers preclinical evidence for the application of Pir in ethanol toxicity. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Dual developmental role of transcriptional regulator Ets1 in Xenopus cardiac neural crest vs. heart mesoderm

    PubMed Central

    Nie, Shuyi; Bronner, Marianne E.

    2015-01-01

    Aims Ets1 is an important transcription factor that is expressed in both the cardiac neural crest (NC) and heart mesoderm of vertebrate embryos. Moreover, Ets1 deletion in humans results in congenital heart abnormalities. To clarify the functional contributions of Ets1 in cardiac NC vs. heart mesoderm, we performed tissue-targeted loss-of-function analysis to compare the relative roles of Ets1 in these two tissues during heart formation using Xenopus embryos as a model system. Methods and results We confirmed by in situ hybridization analysis that Ets1 is expressed in NC and heart mesoderm during embryogenesis. Using a translation-blocking antisense morpholino to knockdown Ets1 protein selectively in the NC, we observed defects in NC delamination from the neural tube, collective cell migration, as well as segregation of NC streams in the cranial and cardiac regions. Many cardiac NC cells failed to reach their destination in the heart, resulting in defective aortic arch artery formation. A different set of defects was noted when Ets1 knockdown was targeted to heart mesoderm. The formation of the primitive heart tube was dramatically delayed and the endocardial tissue appeared depleted. As a result, the conformation of the heart was severely disrupted. In addition, the outflow tract septum was missing, and trabeculae formation in the ventricle was abolished. Conclusion Our study shows that Ets1 is required in both the cardiac NC and heart mesoderm, albeit for different aspects of heart formation. Our results reinforce the suggestion that proper interaction between these tissues is critical for normal heart development. PMID:25691536

  8. The transcription factor ETS-1 regulates angiotensin II-stimulated fibronectin production in mesangial cells.

    PubMed

    Hua, Ping; Feng, Wenguang; Rezonzew, Gabriel; Chumley, Phillip; Jaimes, Edgar A

    2012-06-01

    Angiotensin II (ANG II) produced as result of activation of the renin-angiotensin system (RAS) plays a critical role in the pathogenesis of chronic kidney disease via its hemodynamic effects on the renal microcirculation as well as by its nonhemodynamic actions including the production of extracellular matrix proteins such as fibronectin, a multifunctional extracellular matrix protein that plays a major role in cell adhesion and migration as well as in the development of glomerulosclerosis. ETS-1 is an important transcription factor essential for normal kidney development and glomerular integrity. We previously showed that ANG II increases ETS-1 expression and is required for fibronectin production in mesangial cells. In these studies, we determined that ANG II induces phosphorylation of ETS-1 via activation of the type 1 ANG II receptor and that Erk1/2 and Akt/PKB phosphorylation are required for these effects. In addition, we characterized the role of ETS-1 on the transcriptional activation of fibronectin production in mesangial cells. We determined that ETS-1 directly activates the fibronectin promoter and by utilizing gel shift assays and chromatin immunoprecipitation assays identified two different ETS-1 binding sites that promote the transcriptional activation of fibronectin in response to ANG II. In addition, we identified the essential role of CREB and its coactivator p300 on the transcriptional activation of fibronectin by ETS-1. These studies unveil novel mechanisms involved in RAS-induced production of the extracellular matrix protein fibronectin in mesangial cells and establish the role of the transcription factor ETS-1 as a direct mediator of these effects.

  9. La maladie de Hirayama: à propos de quatre observations tunisiennes et revue de la literature

    PubMed Central

    Amor, Sana Ben; Hassine, Anis; Chatti, Ines; Khefifi, Anissa; Doggui, Mohamed; Harzallah, Mohamed Salah; Benammou, Sofien

    2015-01-01

    Nous rapportons les aspects cliniques et électriques de la maladie de Hirayama en Tunisie à travers une série de quatre observations diagnostiquées au service de neurologie Sahloul. Il s'agit de quatre femmes. L’âge moyen était 30,25 ans avec des extrêmes de 27 et 37 ans. Une patiente avait un antécédent de traumatisme cervical, trois avaient une profession favorisant la position prolongée du rachis cervical en flexion. Un déficit moteur distal et une amyotrophie de la main et de l'avant bras droits d'installation progressive étaient observés dans tous les cas. Il n'avait ni des troubles sensitifs objectifs ni de modification des reflexes ostéotendineux et cutanés. L'EMG montrait une dénervation motrice dans le territoire des muscles dépendants des racines C7, C8, et D1. L'IRM cervicale était sans anomalie dans tous les cas. L’évolution était marquée par la bilatéralisation de la symptomatologie chez une patiente et une stabilisation clinique chez les autres. Ainsi, les aspects cliniques et électriques de la maladie de Hirayama dans cette série tunisienne sont comparables à ceux rapportés dans la littérature en dehors d'une atteinte strictement féminine. PMID:26185570

  10. Evaluating ET estimates from the Simplified Surface Energy Balance (SSEB) model using METRIC model output

    NASA Astrophysics Data System (ADS)

    Senay, G. B.; Budde, M. E.; Allen, R. G.; Verdin, J. P.

    2008-12-01

    Evapotranspiration (ET) is an important component of the hydrologic budget because it expresses the exchange of mass and energy between the soil-water-vegetation system and the atmosphere. Since direct measurement of ET is difficult, various modeling methods are used to estimate actual ET (ETa). Generally, the choice of method for ET estimation depends on the objective of the study and is further limited by the availability of data and desired accuracy of the ET estimate. Operational monitoring of crop performance requires processing large data sets and a quick response time. A Simplified Surface Energy Balance (SSEB) model was developed by the U.S. Geological Survey's Famine Early Warning Systems Network to estimate irrigation water use in remote places of the world. In this study, we evaluated the performance of the SSEB model with the METRIC (Mapping Evapotranspiration at high Resolution and with Internalized Calibration) model that has been evaluated by several researchers using the Lysimeter data. The METRIC model has been proven to provide reliable ET estimates in different regions of the world. Reference ET fractions of both models (ETrF of METRIC vs. ETf of SSEB) were generated and compared using individual Landsat thermal images collected from 2000 though 2005 in Idaho, New Mexico, and California. In addition, the models were compared using monthly and seasonal total ETa estimates. The SSEB model reproduced both the spatial and temporal variability exhibited by METRIC on land surfaces, explaining up to 80 percent of the spatial variability. However, the ETa estimates over water bodies were systematically higher in the SSEB output, which could be improved by using a correction coefficient to take into account the absorption of solar energy by deeper water layers that has little contribution to the ET process. This study demonstrated the usefulness of the SSEB method for large-scale agro-hydrologic applications for operational monitoring and assessing of

  11. Linagliptin reduces effects of ET-1 and TLR2-mediated cerebrovascular hyperreactivity in diabetes.

    PubMed

    Hardigan, Trevor; Abdul, Yasir; Ergul, Adviye

    2016-08-15

    The anti-hyperglycemic agent linagliptin, a dipeptidyl peptidase-4 inhibitor, has been shown to reduce inflammation and improve endothelial cell function. In this study, we hypothesized that DPP-IV inhibition with linagliptin would improve impaired cerebral blood flow in diabetic rats through improved insulin-induced cerebrovascular relaxation and reversal of pathological cerebrovascular remodeling that subsequently leads to improvement of cognitive function. Male type-2 diabetic Goto-Kakizaki (GK) and nondiabetic Wistar rats were treated with linagliptin, and ET-1 plasma levels and dose response curves to ET-1 (0.1-100nM) in basilar arteries were assessed. The impact of TLR2 antagonism on ET-1 mediated basilar contraction and endothelium-dependent relaxation to acetylcholine (ACh, 1nM-1M) in diabetic GK rats was examined with antibody directed against the TLR2 receptor (Santa Cruz, 5μg/mL). The expression of TLR2 in middle cerebral arteries (MCAs) from treated rats and in brain microvascular endothelial cells (BMVEC) treated with 100nM linagliptin was assessed. Linagliptin lowered plasma ET-1 levels in diabetes, and reduced ET-1-induced vascular contraction. TLR2 antagonism in diabetic basilar arteries reduced ET-1-mediated cerebrovascular dysfunction and improved endothelium-dependent vasorelaxation. Linagliptin treatment in the BMVEC was able to reduce TLR2 expression in cells from both diabetic and nondiabetic rats. These results suggest that inhibition of DPPIV using linagliptin improves the ET-1-mediated cerebrovascular dysfunction observed in diabetes through a reduction in ET-1 plasma levels and reduced cerebrovascular hyperreactivity. This effect is potentially a result of linagliptin causing a decrease in endothelial TLR2 expression and a subsequent increase in NO bioavailability. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Right ventricular thrombus with Behçet's syndrome: successful treatment with warfarin and immunosuppressive agents.

    PubMed

    Dogan, Sait M; Birdane, Alparslan; Korkmaz, Cengiz; Ata, Necmi; Timuralp, Bilgin

    2007-01-01

    Behçet's syndrome is a chronic multisystem disease that presents with recurrent oral and genital ulceration and recurrent uveitis. Cardiac involvement is an extremely rare manifestation of this disorder. A 33-year-old man with Behçet's syndrome was admitted to our department with a history of cough, fever, chest pain, hemoptysis, and weight loss. Transthoracic and transesophageal echocardiography revealed a right ventricular thrombus. After 1 month of treatment with warfarin, cyclophosphamide, and corticosteroid, the intracardiac thrombus resolved.

  13. [Discover potential inhibitors of 5-LOX and LTA4H from Rhei Radix et Rhizoma, Notopterygii Rhizoma et Radix and Genitana Macrophyllae Radix based on molecular simulation methods].

    PubMed

    Gu, Yu; Zhang, Xu; Chen, Yan-Kun; Zhao, Bo-Wen; Zhang, Yan-Ling

    2017-12-01

    5-lipoxygenase (5-LOX) and leukotriene A4 hydrolase (LTA4H), as the major targets of 5-LOX branch in the arachidonic acid (AA) metabolic pathway, play an important role in the treatment of inflammation. Rhei Radix et Rhizoma, Notopterygii Rhizoma et Radix and Genitana Macrophyllae Radix have clear anti-inflammation activities. In this paper, the targets of 5-LOX and LTA4H were used as the research carrier, and Hiphop module in DS4.0 (Discovery studio) was used to construct ingredients database for preliminary screening of three traditional Chinese medicines based on target inhibitor pharmacophore, so as to obtain 5-LOX and LTA4H potential active ingredients. The ingredients obtained in initial pharmacophore screening were further screened by using CDOCKER module, and the screening rules were established based on the score of initial compound and the key amino acids to obtain 12 potential 5-LOX inhibitors and 7 potential LTA4H inhibitors. To be more specific, the potential 5-LOX inhibitors included 6 ingredients in Rhei Radix et Rhizoma, such as procyanidins B2-3,3'-O-double gallate and revandchinone 2; four ingredients in notopterygium, such as dodecanoic acid and so on. On the other hand, potential LTA4H inhibitors included revandchinone 1, revandchinone 4 in Rhei Radix et Rhizoma, tridecanoic acid, tetracosanoic acid and methyl eicosanoate in Notopterygii Rhizoma et Radix, montanic acid methyl ester and N-docosanoyl-O-aminobenzoate in Genitana Macrophyllae Radix and so on. The molecular simulation methods were highly efficient and time-saving to obtain the potential inhibitors of 5-LOX and LTA4H, which could provide assistance for discovering the chemical quality indicators of anti-inflammatory efficacy of three Chinese herbs, and may be helpful to promote the whole-process quality control of three Chinese herbs. Copyright© by the Chinese Pharmaceutical Association.

  14. Colon perforation and Budd-Chiari syndrome in Behçet's disease.

    PubMed

    Baş, Yılmaz; Güney, Güven; Uzbay, Pınar; Zobacı, Ethem; Ardalı, Selin; Özkan, Ayşegül Taylan

    2015-05-02

    Behçet's disease is a chronic inflammatory disease involving multiple systems, with vasculitis being the most important pathological feature. Multiple colon perforations are thought to be secondary to vasculitis and they occur in patients with ulcers. These may be encountered within the entire colon but most commonly in the ileocecal region. Intestinal perforation and Budd-Chiari syndrome are infrequent in Behçet's disease, and are associated with high mortality and morbidity. Budd-Chiari syndrome results from occlusion of either hepatic veins or adjacent inferior vena cava, or both. We report a patient with Behçet's disease having multiple perforations in the transverse colon, descending colon, and sigmoid colon. The patient also had Budd-Chiari syndrome due to inferior vena cava thrombosis extending into the right and middle hepatic vein. Our observations are presented with a review of the literature. In Behçet's disease, treatment of colon perforation necessitates urgent surgery, whereas management of Budd-Chiari syndrome is directed towards the underlying cause. Behçet's disease, as a chronic multisystemic disease with various forms of vasculitis, is resistant to medical and surgical treatment. Prognosis is worse in Behçet's disease with colon perforation than that in Budd-Chiari syndrome alone.

  15. A pilot study of the behavior of gas- and particle-phase ETS tracers in residences

    SciT

    Apte, Michael; Gundel, Lara; Dod, Raymond

    2002-02-01

    Our previous study of environmental tobacco smoke (ETS) in a three-room environmental chamber showed that smoking history significantly influenced inter-room ETS transport, particularly of gas-phase nicotine. We conducted a three-home pilot study where smoking was limited to one room. Single-smoker residences were monitored during five one-week periods while the smoker participated in a smoking cessation program. Nicotine traced ETS particles were detected reliably in the smoking rooms (SRs) and unreliably in the non-smoking rooms (NSRs). On average, the ventilation- and volume-normalized smoking rate, 0.1 Cigarette-h{sup -1} m{sup -3}, added about 17 and 4 {micro}g m{sup -3} of ETS particles intomore » the SR and NSR, while average nicotine concentration increases were 2 and 0.06 {micro}g m{sup -3}, respectively. Thus, nicotine tracers may underestimate ETS particle exposure in a NSR (e.g., a child's bedroom) by a factor of 2 to 8. In other words, ETS exposure predicted from nicotine concentrations could be almost an order of magnitude lower than actual exposure.« less

  16. Developpement d'une commande pour une hydrolienne de riviere et optimisation =

    NASA Astrophysics Data System (ADS)

    Tetrault, Philippe

    Suivant le developpement des energies renouvelables, la presente etude se veut une base theorique quant aux principes fondamentaux necessaires au bon fonctionnement et a l'implementation d'une hydrolienne de riviere. La problematique derriere ce nouveau type d'appareil est d'abord presentee. La machine electrique utilisee dans l'application, c'est-a-dire la machine synchrone a aimants permanents, est etudiee : ses equations dynamiques mecaniques et electriques sont developpees, introduisant en meme temps le concept de referentiel tournant. Le fonctionnement de l'onduleur utilise, soit un montage en pont complet a deux niveaux a semi-conducteurs, est explique et mit en equation pour permettre de comprendre les strategies de modulation disponibles. Un bref historique de ces strategies est fait avant de mettre l'emphase sur la modulation vectorielle qui sera celle utilisee pour l'application en cours. Les differents modules sont assembles dans une simulation Matlab pour confirmer leur bon fonctionnement et comparer les resultats de la simulation avec les calculs theoriques. Differents algorithmes permettant de traquer et maintenir un point de fonctionnement optimal sont presentes. Le comportement de la riviere est etudie afin d'evaluer l'ampleur des perturbations que le systeme devra gerer. Finalement, une nouvelle approche est presentee et comparee a une strategie plus conservatrice a l'aide d'un autre modele de simulation Matlab.

  17. Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4.

    PubMed

    Konuma, Tsuyoshi; Yu, Di; Zhao, Chengcheng; Ju, Ying; Sharma, Rajal; Ren, Chunyan; Zhang, Qiang; Zhou, Ming-Ming; Zeng, Lei

    2017-11-24

    Jumonji domain-containing protein 6 (JMJD6) is a member of the Jumonji C family of Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases. It possesses unique bi-functional oxygenase activities, acting as both an arginine demethylase and a lysyl-hydroxylase. JMJD6 has been reported to be over-expressed in oral, breast, lung, and colon cancers and plays important roles in regulation of transcription through interactions with transcription regulator BRD4, histones, U2AF65, Luc7L3, and SRSF11. Here, we report a structural mechanism revealed by NMR of JMJD6 recognition by the extraterminal (ET) domain of BRD4 in that a JMJD6 peptide (Lys84-Asn96) adapts an α-helix when bound to the ET domain. This intermolecular recognition is established through JMJD6 interactions with the conserved hydrophobic core of the ET domain, and reinforced by electrostatic interactions of JMJD6 with residues in the inter-helical α1-α2 loop of the ET domain. Notably, this mode of ligand recognition is different from that of ET domain recognition of NSD3, LANA of herpesvirus, and integrase of MLV, which involves formation of an intermolecular amphipathic two- or three- strand antiparallel β sheet. Furthermore, we demonstrate that the association between the BRD4 ET domain and JMJD6 likely requires a protein conformational change induced by single-stranded RNA binding.

  18. Genetic appraisal of serological response post vaccination against enterotoxaemia (ET) in Malpura and Avikalin sheep.

    PubMed

    Gowane, G R; Akram, Najif; Prince, L L L; Prakash, Ved; Kumar, Arun

    2017-04-01

    Enterotoxaemia (ET) is a fatal enteric disease of small ruminants attributable to a toxigenic type of Clostridium perfringens. The key strategy for prevention of ET is the management and vaccination. Present study aimed at identifying the sources of variation for ET vaccine response especially against epsilon toxin in 173 sheep that included 83 Avikalin and 90 Malpura lambs raised at the institute flock in the semi-arid region of India. The mean age at vaccination was 90 days. Sera were tested by blocking ELISA. Study showed significant variability for response to ET vaccine. 5.2% animals had + positivity, 20.8% animals had ++ positivity, 51.4% animals had +++ positivity and 22.5% animals had ++++ positivity. Amongst environmental determinants, breed, season, sex and age at vaccination proved to be non-significant sources of variation (P > 0.05). MHC genotypes with DRB1 gene and DQA2 genes also revealed non-significant association with ET vaccine response; however, a trend of decreasing PI values with increasing ranks was observed. Study revealed strong response of epsilon toxin along with complexity of the ET vaccine response as phenotype to be explained by genetic and non-genetic factors. The importance of better management practices and vaccination is suggested for preventive measures.

  19. Calendar of Selected Aeronautical and Space Meetings July 1988 (Calendrier des Manifestations Aeronautiques et Spatiales (Selecgion) Juillet 1988)

    DTIC Science & Technology

    1988-07-01

    Environnement terrestre 78 09 - Information, Documentation et Informatique 81 *10 - Themes g~n~raux (phuridisciplinaires) et divers 94 11 - Salons et...Dayton, OH 45432 US UTIIS University of Tokyo Institute of Industrial Science: 7-22-1 Roppongi, Minato-ku, Tokyo 106 JA VDE Verband Deutscher

  20. Calendar of Selected Aeronautical and Space Meetings, July 1989 (Calendrier des Manifestations Aeronautiques et Spatiales (Selection), Juillet 1989)

    DTIC Science & Technology

    1989-07-01

    Matdriaux et Mcanique appliqude 56 08 - Physique de l’Atmosph6re et Environnement terrestre 76 09 - Information, Documentation et Informatique 82 10...S 917, 12201 Sunrise Valley Drive, Reston, VA 22092 US VDE Verband Deutscher Elektrotechniker: Zentralstelle Tagungen, Stresemannallee 15, D-6000

  1. Calendar of Selected Aeronautical and Space Meetings (Calendrier des Manifestations Aeronautiques et Spatiales (Selection). Juillet-July 1984.

    DTIC Science & Technology

    1984-06-01

    Structures, Mat~riaux et M~canique appliquce 47 08 - Physique de l’Atmnosph~re et Environnement terrestre 62 09 - Information, Documentation et...University Institute of Technology: Box 534,75121 Uppsala SW UW University of Wisconsin: Madison, WI 53706 US VDE Verbend Deutacher Elektroteclker

  2. ETS-1 Expression Is Hypoxia-independent in Glioblastoma-derived Endothelial and Mesenchymal Stem-like Cells.

    PubMed

    Koessinger, Dominik; Albrecht, Valerie; Faber, Florian; Jaehnert, Irene; Schichor, Christian

    2018-06-01

    Tumor cells infiltrating the brain are a typical hallmark of glioblastoma. Invasiveness of glioma cells has been associated with ETS proto-oncogene 1 (ETS-1). In non-glial tumors, ETS-1 expression has been linked to hypoxia. However, it is not known whether hypoxia regulates ETS-1 expression in glioblastoma. The spatial distribution of ETS-1 expression in primary glioblastoma was assessed using immunohistochemistry. ETS-1 expression in glioblastoma-derived mesenchymal stem-like cells (gbMSLCs) was determined using immunocytochemistry. The effect of hypoxia on ETS-1 expression of gbMSLCs, glioma cell lines and glioblastoma-derived endothelial cells was assessed using polymerase chain reaction and immunoblotting. Our immunohistochemical studies revealed ETS-1 expression in stromal and endothelial glioblastoma cells. Stromal ETS-1 expression in glioblastoma correlated with microvessel density. gbMSLCs were found to express ETS-1. In all examined cell lines, ETS-1 transcription and expression were independent of hypoxia. In glioblastoma, ETS-1-expression is not dependent on hypoxia, but correlates with tumor vascularization. Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  3. 75 FR 36689 - United States, et al. v. Election Systems & Software, Inc.; Public Comments and Response on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ... DEPARTMENT OF JUSTICE Antitrust Division United States, et al. v. Election Systems & Software, Inc... proposed Final Judgment in United States, et al. v. Election Systems & Software Inc., Case No. 1:10-00380... America, et al., Plaintiffs, v. Election Systems and Software, Inc., Defendant. Case No.: 1:10-cv-00380...

  4. Review of the genus Neotetricodes Zhang et Chen (Hemiptera: Fulgoromorpha: Issidae) with description of two new species.

    PubMed

    Chang, Zhi-Min; Yang, Lin; Zhang, Zheng-Guang; Chen, Xiang-Sheng

    2015-12-11

    Two new species of the issid genus Neotetricodes Zhang et Chen (Hemiptera: Fulgoromorpha: Issidae): Neotetricodes longispinus Chang et Chen sp. nov. (China: Yunnan) and Neotetricodes xiphoideus Chang et Chen sp. nov. (China: Yunnan) are described and illustrated. The generic characteristic is redefined. A checklist and key to the species of the genus are provided. The female genitalia of the genus are firstly described.

  5. Etude de pratiques d'enseignement relatives a la modelisation en sciences et technologies avec des enseignants du secondaire

    NASA Astrophysics Data System (ADS)

    Aurousseau, Emmanuelle

    Les modeles sont des outils amplement utilises en sciences et technologies (S&T) afin de representer et d’expliquer un phenomene difficilement accessible, voire abstrait. La demarche de modelisation est presentee de maniere explicite dans le programme de formation de l’ecole quebecoise (PFEQ), notamment au 2eme cycle du secondaire (Quebec. Ministere de l'Education du Loisir et du Sport, 2007a). Elle fait ainsi partie des sept demarches auxquelles eleves et enseignants sont censes recourir. Cependant, de nombreuses recherches mettent en avant la difficulte des enseignants a structurer leurs pratiques d’enseignement autour des modeles et de la demarche de modelisation qui sont pourtant reconnus comme indispensables. En effet, les modeles favorisent la conciliation des champs concrets et abstraits entre lesquels le scientifique, meme en herbe, effectue des allers-retours afin de concilier le champ experimental de reference qu’il manipule et observe au champ theorique relie qu’il construit. L’objectif de cette recherche est donc de comprendre comment les modeles et la demarche de modelisation contribuent a faciliter l’articulation du concret et de l’abstrait dans l’enseignement des sciences et des technologies (S&T) au 2eme cycle du secondaire. Pour repondre a cette question, nous avons travaille avec les enseignants dans une perspective collaborative lors de groupes focalises et d’observation en classe. Ces dispositifs ont permis d’examiner les pratiques d’enseignement que quatre enseignants mettent en oeuvre en utilisant des modeles et des demarches de modelisation. L’analyse des pratiques d’enseignement et des ajustements que les enseignants envisagent dans leur pratique nous permet de degager des connaissances a la fois pour la recherche et pour la pratique des enseignants, au regard de l’utilisation des modeles et de la demarche de modelisation en S&T au secondaire.

  6. L’identification et traitement du trouble panique avec ou sans agoraphobie

    PubMed Central

    Foldes-Busque, Guillaume; Marchand, André; Landry, Pierre

    2007-01-01

    RÉSUMÉ OBJECTIF Renseigner les médecins de première ligne au sujet de l’identification précoce, du diagnostic et du traitement du trouble panique avec ou sans agoraphobie (TP/A). QUALITÉ DES DONNÉES Les données et recommandations présentées proviennent d’une recension des écrits scientifiques réalisée via les banques de données PsycLIT, PsyINFO et MEDLINE (1985 à 2006) en utilisant les descripteurs panic disorder, psychotherapy, psychosocial treatment, treatment et pharmacotherapy. Les recommandations formulées par les auteurs s’appuient sur des données probantes provenant d’études d’excellente qualité. Les informations concernant le diagnostic et l’évaluation du TP/A proviennent d’études épidémiologiques récentes, de consensus et d’opinions d’experts. PRINCIPAL MESSAGE Le TP/A est un trouble psychiatrique souvent rencontré en médecine de première ligne, mais il est fréquemment sous-diagnostiqué et sous-traité. L’identification précoce de ce trouble demande une attention particulière aux symptômes médicalement inexpliqués et, le cas échéant, le médecin doit utiliser des questions spécifiques permettant d’identifier d’éventuelles attaques de panique et de cerner leur signification pour le patient. Le traitement de premier choix pour ce trouble est une psychothérapie d’orientation cognitivo-comportementale administrée par un psychologue ou un psychiatre spécialisé. Si de telles ressources ne sont pas disponibles, le médecin peut opter pour un traitement psychopharmacologique. CONCLUSION Les médecins de famille peuvent jouer un rôle central dans l’identification et le traitement des patients souffrant d’un TP/A. PMID:17934032

  7. Analyse des interactions energetiques entre un arena et son systeme de refrigeration

    NASA Astrophysics Data System (ADS)

    Seghouani, Lotfi

    La presente these s'inscrit dans le cadre d'un projet strategique sur les arenas finance par le CRSNG (Conseil de Recherche en Sciences Naturelles et en Genie du Canada) qui a pour but principal le developpement d'un outil numerique capable d'estimer et d'optimiser la consommation d'energie dans les arenas et curlings. Notre travail s'inscrit comme une suite a un travail deja realise par DAOUD et coll. (2006, 2007) qui a developpe un modele 3D (AIM) en regime transitoire de l'arena Camilien Houde a Montreal et qui calcule les flux de chaleur a travers l'enveloppe du batiment ainsi que les distributions de temperatures et d'humidite durant une annee meteorologique typique. En particulier, il calcule les flux de chaleur a travers la couche de glace dus a la convection, la radiation et la condensation. Dans un premier temps nous avons developpe un modele de la structure sous la glace (BIM) qui tient compte de sa geometrie 3D, des differentes couches, de l'effet transitoire, des gains de chaleur du sol en dessous et autour de l'arena etudie ainsi que de la temperature d'entree de la saumure dans la dalle de beton. Par la suite le BIM a ete couple le AIM. Dans la deuxieme etape, nous avons developpe un modele du systeme de refrigeration (REFSYS) en regime quasi-permanent pour l'arena etudie sur la base d'une combinaison de relations thermodynamiques, de correlations de transfert de chaleur et de relations elaborees a partir de donnees disponibles dans le catalogue du manufacturier. Enfin le couplage final entre l'AIM +BIM et le REFSYS a ete effectue sous l'interface du logiciel TRNSYS. Plusieurs etudes parametriques on ete entreprises pour evaluer les effets du climat, de la temperature de la saumure, de l'epaisseur de la glace, etc. sur la consommation energetique de l'arena. Aussi, quelques strategies pour diminuer cette consommation ont ete etudiees. Le considerable potentiel de recuperation de chaleur au niveau des condenseurs qui peut reduire l'energie requise par

  8. Towards reliable ET estimates in the semi-arid Júcar region in Spain.

    NASA Astrophysics Data System (ADS)

    Brenner, Johannes; Zink, Matthias; Schrön, Martin; Thober, Stephan; Rakovec, Oldrich; Cuntz, Matthias; Merz, Ralf; Samaniego, Luis

    2017-04-01

    Current research indicated the potential for improving evapotranspiration (ET) estimates in state-of-the-art hydrologic models such as the mesoscale Hydrological Model (mHM, www.ufz.de/mhm). Most models exhibit deficiencies to estimate the ET flux in semi-arid regions. Possible reasons for poor performance may be related to the low resolution of the forcings, the estimation of the PET, which is in most cases based on temperature only, the joint estimation of the transpiration and evaporation through the Feddes equation, poor process parameterizations, among others. In this study, we aim at sequential hypothesis-based experiments to uncover the main reasons of these deficiencies at the Júcar basin in Spain. We plan the following experiments: 1) Use the high resolution meteorological forcing (P and T) provided by local authorities to estimate its effects on ET and streamflow. 2) Use local ET measurements at seven eddy covariance stations to estimate evaporation related parameters. 3) Test the influence of the PET formulations (Hargreaves-Samani, Priestley-Taylor, Penman-Montheith). 4) Estimate evaporation and transpiration separately based on equations proposed by Bohn and Vivoni (2016) 5) Incorporate local soil moisture measurements to re-estimate ET and soil moisture related parameters. We set-up mHM for seven eddy-covariance sites at the local scale (100 × 100 m2). This resolution was chosen because it is representative for the footprint of the latent heat estimation at the eddy-covariance station. In the second experiment, for example, a parameter set is to be found as a compromised solution between ET measured at local stations and the streamflow observations at eight sub-basins of the Júcar river. Preliminary results indicate that higher model performance regarding streamflow can be achieved using local high-resolution meteorology. ET performance is, however, still deficient. On the contrary, using ET site calibrations alone increase performance in ET but

  9. Fluctuations quantiques et instabilites structurales dans les conducteurs a basse dimensionalite

    NASA Astrophysics Data System (ADS)

    Dikande, Alain Moise

    Un engouement particulier s'est manifeste ces dernieres annees pour les systemes electroniques fortement correles, ce en rapport avec l'immense richesse de leurs proprietes physiques. En general, ces proprietes sont induites par la presence d'interactions entre electrons qui, combinees a la structure du reseau moleculaire, donnent parfois lieu a une tres grande variete de phases electroniques et structurales ayant des incidences directes sur les phenomenes de transport dans ces materiaux. Les systemes electroniques couples a un reseau moleculaire et designes systemes electron-phonon font partie de cette classe de materiaux qui ont recemment capte l'attention, en raison notamment de la competition entre plusieurs echelles d'energie dans un environnement caracterise par une forte anisotropie cristalline et une dynamique moleculaire assez importante. En effet, en plus des proprietes electroniques et structurales particulieres la dimensionalite de ces systemes contribue egalement a leur richesse. Ainsi, une tres forte anisotropie structurale peut rehausser de facon considerable l'importance des interactions entre electrons et entre molecules constituant le reseau au point ou la physique du systeme soit regie par de tres fortes fluctuations. Ce dernier contexte est devenu un domaine a part de la physique des systemes fortement correles, a savoir celui des les phenomenes critiques quantiques . Parmi les systemes electron-phonon, on retrouve les composes inorganique KCP et organique TTF-TCNQ decouverts durant les annees 70, et explores en profondeur a cause de leur tendance vers une instabilite du type onde de densite de charge a basse temperature. Ces composes, en general designes systemes de Peierls en reference a l'instabilite de leurs structures electroniques regie par le reseau moleculaire, ont recemment connu un regain d'interet a la lumiere des nouveaux developpements dans les techniques de caracterisation des structures electroniques ainsi que sur le plan de

  10. Upregulation of human heme oxygenase gene expression by Ets-family proteins.

    PubMed

    Deramaudt, B M; Remy, P; Abraham, N G

    1999-03-01

    Overexpression of human heme oxygenase-1 has been shown to have the potential to promote EC proliferation and angiogenesis. Since Ets-family proteins have been shown to play an important role in angiogenesis, we investigated the presence of ETS binding sites (EBS), GGAA/T, and ETS protein contributing to human HO-1 gene expression. Several chloramphenicol acetyltransferase constructs were examined in order to analyze the effect of ETS family proteins on the transduction of HO-1 in Xenopus oocytes and in microvessel endothelial cells. Heme oxygenase promoter activity was up-regulated by FLI-1ERGETS-1 protein(s). Chloramphenicol acetyltransferase (CAT) assays demonstrated that the promoter region (-1500 to +19) contains positive and negative control elements and that all three members of the ETS protein family were responsible for the up-regulation of HHO-1. Electrophoretic mobility shift assays (EMSA), performed with nuclear extracts from endothelial cells overexpressing HHO-1 gene, and specific HHO-1 oligonucleotides probes containing putative EBS resulted in a specific and marked bandshift. Synergistic binding was observed in EMSA between AP-1 on the one hand, FLI-1, ERG, and ETS-1 protein on the other. Moreover, 5'-deletion analysis demonstrated the existence of a negative control element of HHO-1 expression located between positions -1500 and -120 on the HHO-1 promoter. The presence of regulatory sequences for transcription factors such as ETS-1, FLI-1, or ERG, whose activity is associated with cell proliferation, endothelial cell differentiation, and matrix metalloproteinase transduction, may be an indication of the important role that HO-1 may play in coronary collateral circulation, tumor growth, angiogenesis, and hemoglobin-induced endothelial cell injuries.

  11. Un accumulateur echangeur de chaleur hybride pour la gestion simultanee des energies solaire et electrique

    NASA Astrophysics Data System (ADS)

    Ait Hammou, Zouhair

    Cette etude porte sur la conception d'un accumulateur echangeur de chaleur hybride (AECH) pour la gestion simultanee des energies solaire et electrique. Un modele mathematique reposant sur les equations de conservation de la quantite d'energie est expose. Il est developpe pour tester differents materiaux de stockage, entre autres, les materiaux a changement de phase (solide/liquide) et les materiaux de stockage sensible. Un code de calcul est mis en eeuvre sur ordinateur, puis valide a l'aide des resultats analytiques et numeriques de la litterature. En parallele, un prototype experimental a echelle reduite est concu au laboratoire afin de valider le code de calcul. Des simulations sont effectuees pour etudier les effets des parametres de conception et des materiaux de stockage sur le comportement thermique de l'AECH et sur la consommation d'energie electrique. Les resultats des simulations sur quatre mois d'hiver montrent que la paraffine n-octadecane et l'acide caprique sont deux candidats souhaitables pour le stockage d'energie destine au chauffage des habitats. L'utilisation de ces deux materiaux dans l'AECH permet de reduire la consommation d'energie electrique de 32% et d'aplanir le probleme de pointe electrique puisque 90% de l'energie electrique est consommee durant les heures creuses. En plus, en adoptant un tarif preferentiel, le calcul des couts lies a la consommation d'energie electrique montre que le consommateur adoptant ce systeme beneficie d'une reduction de 50% de la facture d'electricite.

  12. Improving evapotranspiration processes in distrubing hydrological models using Remote Sensing derived ET products.

    NASA Astrophysics Data System (ADS)

    Abitew, T. A.; van Griensven, A.; Bauwens, W.

    2015-12-01

    Evapotranspiration is the main process in hydrology (on average around 60%), though has not received as much attention in the evaluation and calibration of hydrological models. In this study, Remote Sensing (RS) derived Evapotranspiration (ET) is used to improve the spatially distributed processes of ET of SWAT model application in the upper Mara basin (Kenya) and the Blue Nile basin (Ethiopia). The RS derived ET data is obtained from recently compiled global datasets (continuously monthly data at 1 km resolution from MOD16NBI,SSEBop,ALEXI,CMRSET models) and from regionally applied Energy Balance Models (for several cloud free days). The RS-RT data is used in different forms: Method 1) to evaluate spatially distributed evapotransiration model resultsMethod 2) to calibrate the evotranspiration processes in hydrological modelMethod 3) to bias-correct the evapotranpiration in hydrological model during simulation after changing the SWAT codesAn inter-comparison of the RS-ET products shows that at present there is a significant bias, but at the same time an agreement on the spatial variability of ET. The ensemble mean of different ET products seems the most realistic estimation and was further used in this study.The results show that:Method 1) the spatially mapped evapotranspiration of hydrological models shows clear differences when compared to RS derived evapotranspiration (low correlations). Especially evapotranspiration in forested areas is strongly underestimated compared to other land covers.Method 2) Calibration allows to improve the correlations between the RS and hydrological model results to some extent.Method 3) Bias-corrections are efficient in producing (sesonal or annual) evapotranspiration maps from hydrological models which are very similar to the patterns obtained from RS data.Though the bias-correction is very efficient, it is advised to improve the model results by better representing the ET processes by improved plant/crop computations, improved

  13. Seroprevalence of Borrelia burgdorferi in patients with Behçet's disease.

    PubMed

    Onen, Fatos; Tuncer, Dilek; Akar, Servet; Birlik, Merih; Akkoc, Nurullah

    2003-11-01

    Turkey is one of the countries where Behçet's disease is most prevalent. Although its pathogenesis is not defined clearly, infectious agents are thought to play a role in the etiology. In one study of a group of uveitis patients, including those with Behçet's disease, increased seropositivity to B. burgdorferi was reported by enzyme-linked immunosorbent assay (ELISA). The seroprevalence of B. burgdorferi has been found to be as high as 36% in some rural areas of Turkey, although Lyme disease caused by B. burgdorferi is quite rare. In this study, we investigated the seroreactivity to B. burgdorferi antigens in patients with Behçet's disease and compared it with that of healthy and disease controls. This study was conducted in Izmir in western Turkey. B. burgdorferi immunoglobulin (Ig)M and IgG antibodies were tested by ELISA in the sera of patients with Behçet's disease ( n=30), rheumatoid arthritis patients as disease controls ( n=31), and healthy controls ( n=31). Positive results were confirmed by Western blotting. The difference in B. burgdorferi seropositivity between the groups was not significant by any method. Seroreactivity to B. burgdorferi antigens by ELISA was detected in 26.7% of the patients with Behçet's disease, 35.5% of those with rheumatoid arthritis, and 19.4% of the healthy controls. Immunoblots were positive in 13.3% of the Behçet's disease patients, 22.6% of the rheumatoid arthritis patients, and 12.9% of healthy controls. These results suggest no association between Behçet's disease and B. burgdorferi infection.

  14. De Sedibus et Causis Morborum: is Essential Tremor a Primary Disease of the Cerebellum?

    PubMed

    Louis, Elan D

    2016-06-01

    Morgagni's 1761 publication of De sedibus et causis morborum (i.e., of the Seats and Causes of Diseases) represented a paradigmatic moment in the history of medicine. The book ushered in a new way of conceptualizing human disease, shattering old dogma, and linking constellations of symptoms and signs (i.e., clinical disease) with anatomic pathology in specific organs (i.e., organ disease). This was the anatomical-clinical method, and it attempted to unveil "the seat" of each disease in a specific organ. Essential tremor (ET) is among the most common neurological diseases. There is little debate that the origin of ET lies in the brain, but if one tries to delve more deeply than this, things become murky. The dogma for the past 40 years has been that the seat of ET is the inferior olivary nucleus. Closer scrutiny of this model, however, has revealed its many flaws, and the model, based on little if any empiric evidence, has increasingly lost favor. Arising from a wealth of research in recent years is a growing body of knowledge that links ET to a disarrangement of the cerebellum. Data from a variety of sources reviewed in this issue (clinical, neuroimaging, neurochemical, animal model, physiological, and pathological) link ET to the cerebellum. That the cerebellum is involved in an abnormal brain loop that is responsible for ET is not debated. The tantalizing question is whether an abnormality in the cerebellum is the prime mover, and whether the cerebellum is the seat of this particular disease.

  15. Involvement of endothelin and ET(A) endothelin receptor in mechanical allodynia in mice given orthotopic melanoma inoculation.

    PubMed

    Fujita, Masahide; Andoh, Tsugunobu; Saiki, Ikuo; Kuraishi, Yasushi

    2008-02-01

    We investigated whether endothelin (ET) would be involved in skin cancer pain in mice. Orthotopic inoculation of B16-BL6 melanoma cells into the plantar region of the hind paw produced marked mechanical allodynia in C57BL/6 mice. Intraplantar injections of the ET(A)-receptor antagonist BQ-123 (0.3 - 3 nmol/site), but not the ET(B)-receptor antagonist BQ-788 (1 and 3 nmol/site), inhibited mechanical allodynia in mice with grown melanoma. In naive mice, an intraplantar injection of tumor extract (1 and 3 mg/site), which was prepared from the grown melanoma in the paw, produced mechanical allodynia, which was inhibited by BQ-123 and BQ-788 at doses of 3 and 10 nmol/site. An intraplantar injection of ET-1 (1 and 10 pmol/site) elicited licking behavior, which was increased in the melanoma-bearing hind paw. BQ-123 (3 and 10 nmol/site) inhibited licking induced by ET-1 (10 pmol/site). The level of mRNA of ET(A), but not ET(B), receptor, was significantly increased in the dorsal root ganglia on the inoculated side. Cultured B16-BL6 cells contained ET, and the melanoma mass increased the concentration of ET as it grew bigger. These results suggest that ET-1 and ET(A) receptor are at least partly involved in the induction of pain induced by melanoma cell inoculation.

  16. Low-temperature MOCVD deposition of Bi2Te3 thin films using Et2BiTeEt as single source precursor

    NASA Astrophysics Data System (ADS)

    Bendt, Georg; Gassa, Sanae; Rieger, Felix; Jooss, Christian; Schulz, Stephan

    2018-05-01

    Et2BiTeEt was used as single source precursor for the deposition of Bi2Te3 thin films on Si(1 0 0) substrates by metal organic chemical vapor deposition (MOCVD) at very low substrate temperatures. Stoichiometric and crystalline Bi2Te3 films were grown at 230 °C, which is approximately 100 °C lower compared to conventional MOCVD processes using one metal organic precursors for each element. The Bi2Te3 films were characterized using scanning electron microscopy, high-resolution transmission electron microscopy and X-ray diffraction. The elemental composition of the films, which was determined by energy-dispersive X-ray spectroscopy and X-ray photoelectron spectroscopy, was found to be strongly dependent of the substrate temperature.

  17. Mesure et retroaction sur un qubit multi-niveaux en electrodynamique quantique en circuit non lineair

    NASA Astrophysics Data System (ADS)

    Boissonneault, Maxime

    L'electrodynamique quantique en circuit est une architecture prometteuse pour le calcul quantique ainsi que pour etudier l'optique quantique. Dans cette architecture, on couple un ou plusieurs qubits supraconducteurs jouant le role d'atomes a un ou plusieurs resonateurs jouant le role de cavites optiques. Dans cette these, j'etudie l'interaction entre un seul qubit supraconducteur et un seul resonateur, en permettant cependant au qubit d'avoir plus de deux niveaux et au resonateur d'avoir une non-linearite Kerr. Je m'interesse particulierement a la lecture de l'etat du qubit et a son amelioration, a la retroaction du processus de mesure sur le qubit de meme qu'a l'etude des proprietes quantiques du resonateur a l'aide du qubit. J'utilise pour ce faire un modele analytique reduit que je developpe a partir de la description complete du systeme en utilisant principalement des transfprmations unitaires et une elimination adiabatique. J'utilise aussi une librairie de calcul numerique maison permettant de simuler efficacement l'evolution du systeme complet. Je compare les predictions du modele analytique reduit et les resultats de simulations numeriques a des resultats experimentaux obtenus par l'equipe de quantronique du CEASaclay. Ces resultats sont ceux d'une spectroscopie d'un qubit supraconducteur couple a un resonateur non lineaire excite. Dans un regime de faible puissance de spectroscopie le modele reduit predit correctement la position et la largeur de la raie. La position de la raie subit les decalages de Lamb et de Stark, et sa largeur est dominee par un dephasage induit par le processus de mesure. Je montre que, pour les parametres typiques de l'electrodynamique quantique en circuit, un accord quantitatif requiert un modele en reponse non lineaire du champ intra-resonateur, tel que celui developpe. Dans un regime de forte puissance de spectroscopie, des bandes laterales apparaissent et sont causees par les fluctuations quantiques du champ electromagnetique

  18. ETS target genes: Identification of Egr1 as a target by RNA differential display and whole genome PCR techniques

    PubMed Central

    Robinson, Lois; Panayiotakis, Alexandra; Papas, Takis S.; Kola, Ismail; Seth, Arun

    1997-01-01

    ETS transcription factors play important roles in hematopoiesis, angiogenesis, and organogenesis during murine development. The ETS genes also have a role in neoplasia, for example in Ewing’s sarcomas and retrovirally induced cancers. The ETS genes encode transcription factors that bind to specific DNA sequences and activate transcription of various cellular and viral genes. To isolate novel ETS target genes, we used two approaches. In the first approach, we isolated genes by the RNA differential display technique. Previously, we have shown that the overexpression of ETS1 and ETS2 genes effects transformation of NIH 3T3 cells and specific transformants produce high levels of the ETS proteins. To isolate ETS1 and ETS2 responsive genes in these transformed cells, we prepared RNA from ETS1, ETS2 transformants, and normal NIH 3T3 cell lines and converted it into cDNA. This cDNA was amplified by PCR and displayed on sequencing gels. The differentially displayed bands were subcloned into plasmid vectors. By Northern blot analysis, several clones showed differential patterns of mRNA expression in the NIH 3T3-, ETS1-, and ETS2-expressing cell lines. Sixteen clones were analyzed by DNA sequence analysis, and 13 of them appeared to be unique because their DNA sequences did not match with any of the known genes present in the gene bank. Three known genes were found to be identical to the CArG box binding factor, phospholipase A2-activating protein, and early growth response 1 (Egr1) genes. In the second approach, to isolate ETS target promoters directly, we performed ETS1 binding with MboI-cleaved genomic DNA in the presence of a specific mAb followed by whole genome PCR. The immune complex-bound ETS binding sites containing DNA fragments were amplified and subcloned into pBluescript and subjected to DNA sequence and computer analysis. We found that, of a large number of clones isolated, 43 represented unique sequences not previously identified. Three clones turned out to

  19. Diesel engine exhaust and lung cancer risks - evaluation of the meta-analysis by Vermeulen et al. 2014.

    PubMed

    Morfeld, Peter; Spallek, Michael

    2015-01-01

    Vermeulen et al. 2014 published a meta-regression analysis of three relevant epidemiological US studies (Steenland et al. 1998, Garshick et al. 2012, Silverman et al. 2012) that estimated the association between occupational diesel engine exhaust (DEE) exposure and lung cancer mortality. The DEE exposure was measured as cumulative exposure to estimated respirable elemental carbon in μg/m(3)-years. Vermeulen et al. 2014 found a statistically significant dose-response association and described elevated lung cancer risks even at very low exposures. We performed an extended re-analysis using different modelling approaches (fixed and random effects regression analyses, Greenland/Longnecker method) and explored the impact of varying input data (modified coefficients of Garshick et al. 2012, results from Crump et al. 2015 replacing Silverman et al. 2012, modified analysis of Moehner et al. 2013). We reproduced the individual and main meta-analytical results of Vermeulen et al. 2014. However, our analysis demonstrated a heterogeneity of the baseline relative risk levels between the three studies. This heterogeneity was reduced after the coefficients of Garshick et al. 2012 were modified while the dose coefficient dropped by an order of magnitude for this study and was far from being significant (P = 0.6). A (non-significant) threshold estimate for the cumulative DEE exposure was found at 150 μg/m(3)-years when extending the meta-analyses of the three studies by hockey-stick regression modelling (including the modified coefficients for Garshick et al. 2012). The data used by Vermeulen and colleagues led to the highest relative risk estimate across all sensitivity analyses performed. The lowest relative risk estimate was found after exclusion of the explorative study by Steenland et al. 1998 in a meta-regression analysis of Garshick et al. 2012 (modified), Silverman et al. 2012 (modified according to Crump et al. 2015) and Möhner et al. 2013. The meta-coefficient was

  20. Les syndromes coronaires aigus à Dakar: aspects cliniques thérapeutiques et évolutifs

    PubMed Central

    Mboup, Mouhamed Cherif; Diao, Maboury; Dia, Khadidiatou; Fall, Pape Diadie

    2014-01-01

    Introduction Ce travail a pour objectifs d’étudier les aspects épidémiologiques et cliniques, les différentes modalités de prise en charge, et l’évolution des syndromes coronaires aigus à Dakar. Méthodes Il s'agit d'une étude prospective concernant une cohorte de patients hospitalisés au niveau des services de cardiologie de l'hôpital Principal de Dakar et de l'hôpital Aristide Le Dantec pour un syndrome coronaire aigu entre le 01 Septembre 2005 et le 31 Août 2006. Résultats Durant la période d’étude, 59 patients avaient présenté à l'admission un syndrome coronaire aigu, soit une prévalence hospitalière de 4,05%. L’âge moyen était de 57,1 ± 3,5 ans. L'indice moyen des facteurs de risque était de 3,56 ± 1,7. Quatre vingt onze pour cent (91%) des patients avaient au moins deux facteurs de risque cardio-vasculaires. Les délais moyens d'arrivée et de prise en charge étaient respectivement de 53,2 ± 21,3 heures et 3,4 ± 1 heures. L'analyse des tracés électrocardiographiques associée au dosage des troponines, avait permis de retenir les diagnostics d'infarctus du myocarde avec sus-décalage persistant du segment ST chez 89,8% patients, d'infarctus du myocarde sans sus-décalage du segment ST chez 5,1% patients, et d'angor instable dans 5,1% des cas. La mortalité hospitalière était de 15,25% et la mortalité à un mois de 18,64%. Conclusion Au Sénégal, les syndromes coronaires aigus sont caractérisés par un âge de survenue relativement jeune chez des patients polyfactoriels et une lourde mortalité. C'est dire tout l'intérêt d'une prévention primaire efficace par la lutte contre les facteurs de risque cardio-vasculaires. PMID:25745533

  1. DraGnET: Software for storing, managing and analyzing annotated draft genome sequence data

    PubMed Central

    2010-01-01

    Background New "next generation" DNA sequencing technologies offer individual researchers the ability to rapidly generate large amounts of genome sequence data at dramatically reduced costs. As a result, a need has arisen for new software tools for storage, management and analysis of genome sequence data. Although bioinformatic tools are available for the analysis and management of genome sequences, limitations still remain. For example, restrictions on the submission of data and use of these tools may be imposed, thereby making them unsuitable for sequencing projects that need to remain in-house or proprietary during their initial stages. Furthermore, the availability and use of next generation sequencing in industrial, governmental and academic environments requires biologist to have access to computational support for the curation and analysis of the data generated; however, this type of support is not always immediately available. Results To address these limitations, we have developed DraGnET (Draft Genome Evaluation Tool). DraGnET is an open source web application which allows researchers, with no experience in programming and database management, to setup their own in-house projects for storing, retrieving, organizing and managing annotated draft and complete genome sequence data. The software provides a web interface for the use of BLAST, allowing users to perform preliminary comparative analysis among multiple genomes. We demonstrate the utility of DraGnET for performing comparative genomics on closely related bacterial strains. Furthermore, DraGnET can be further developed to incorporate additional tools for more sophisticated analyses. Conclusions DraGnET is designed for use either by individual researchers or as a collaborative tool available through Internet (or Intranet) deployment. For genome projects that require genome sequencing data to initially remain proprietary, DraGnET provides the means for researchers to keep their data in-house for

  2. Dynamique de nanobulles et nanoplasmas generes autour de nanoparticules plasmoniques irradiees par des impulsions ultracourtes

    NASA Astrophysics Data System (ADS)

    Dagallier, Adrien

    L'emergence des lasers a impulsion ultrabreves et des nanotechnologies a revolutionne notre perception et notre maniere d'interagir avec l'infiniment petit. Les gigantesques intensites generees par ces impulsions plus courtes que les temps de relaxation ou de diffusion du milieu irradie induisent de nombreux phenomenes non-lineaires, du doublement de frequence a l'ablation, dans des volumes de dimension caracteristique de l'ordre de la longueur d'onde du laser. En biologie et en medecine, ces phenomenes sont utilises a des fins d'imagerie multiphotonique ou pour detruire des tissus vivants. L'introduction de nanoparticules plasmoniques, qui concentrent le champ electromagnetique incident dans des regions de dimensions nanometriques, jusqu'a une fraction de la longueur d'onde, amplifie les phenomenes non-lineaires tout en offrant un controle beaucoup plus precis de la deposition d'energie, ouvrant la voie a la detection de molecules individuelles en solution et a la nanochirurgie. La nanochirurgie repose principalement sur la formation d'une bulle de vapeur a proximite d'une membrane cellulaire. Cette bulle de vapeur perce la membrane de maniere irreversible,entrainant la cellule a sa mort, ou la perturbe temporairement, ce qui permet d'envisager de faire penetrer dans la cellule des medicaments ou des brins d'ADN pour de la therapie genique. C'est principalement la taille de la bulle qui va decider de l'issue de l'irradiation laser. Il est donc necessaire de controler finement les parametres du laser et la geometrie de la nanoparticule afin d'atteindre l'objectif fixe. Le moyen le plus direct a l'heure actuelle de valider un ensemble de conditions experimentales est de realiser l'experience en laboratoire,ce qui est long et couteux. Les modeles de dynamique de bulle existants ne prennent pas en compte les parametres de l'irradiation et ajustent souvent leurs conditions initiales a partir de leurs mesures experimentales, ce qui limite la portee du modele au cas pour

  3. Neurocytomes centraux: corrélations cliniques et radiopathologiques à propos de 12 observations

    PubMed Central

    Abbad, Fayçal; Sellami, Souad; Hazmiri, Fe; Idriss Ganouni, Najat El; Benali, Said Ait; Khouchani, Mouna; Rais, Hanane

    2017-01-01

    Les neurocytomes centraux sont définis comme étant des néoplasmes composés de cellules rondes, uniformes, ayant un profil immunophénotypique neuronal et un index de prolifération bas. Elles représentent 0,5% des tumeurs intracrâniennes. Elles sont habituellement situées à proximité du foramen de Monro et peuvent être à l’origine d’une hydrocéphalie obstructive. Nous rapportons 12 observations de neurocytomes centraux colligés au laboratoire d’anatomie pathologique du CHU Mohammed VI de Marrakech entre janvier 2006 et juin 2015. Le but de ce travail est de rapporter et décrire les aspects radio-pathologiques de ce type histologique rare. Le sex-ratio homme/femme était de 1,4. L’âge moyen au diagnostic était de 22,3 ans. La symptomatologie révélatrice était dominée par l’hypertension intracrânienne chez tous nos patients, associée à une baisse de l’acuité visuelle et une diplopie. Notre matériel d’étude a concerné une biopsie simple dans un cas, une exérèse subtotale dans sept cas et une exérèse totale dans quatre cas. L’étude histopathologique a montré une prolifération tumorale d’architecture endocrine. Les cellules tumorales sont uniformes de petite taille le plus souvent. L’index mitotique était bas. Cette prolifération tumorale s’accompagnait d’un fond fibrillaire et d’un réseau vasculaire développé de type arborescent. L’étude immunohistochimique était identique chez tout les patients. Elle a montré une positivité des cellules tumorales à l’anticorps anti synaptophysine, à chromogranine et NSE. Chez tous nos patients la corrélation radiopathologique était en faveur d’un neurocytome central (Grade II – OMS 2016). A travers cette série, nous rapportons les particularités anatomo-cliniques, radiologiques et évolutives de ces tumeurs rares. PMID:28979624

  4. Pratique anesthésique à Lubumbashi: indications, types de chirurgie et types de patient

    PubMed Central

    Kabey, Alain Kabey a; Lubanga, Muyumba; Tshamba, Mundongo; Kaut, Mukeng; Kakambal, Kaij; Muteya, Manika; Manzanza, Kilembe; Kalal, Kapend

    2015-01-01

    Introduction Cette étude a pour objectif de décrire la pratique anesthésique dans un pays à faible revenu et où le plateau technique anesthésique est moins équipé. Méthodes Une étude descriptive transversale a été menée durant l'année 2013. L'enquête a concerné les pratiques anesthésiques, les indications chirurgicales et les caractéristiques des malades. L'encodage et l'analyse des données ont été réalisées grâce aux logiciels Epi Info 3.5.3 et Excel 2010. Résultats Nous avons enregistré 2358 patients dont l’âge médian était de 29 + 15 ans, avec 81,5% âgés de 11 à 50 ans. Parmi eux, 67,3% des malades étaient du sexe féminin. Dans ensemble, 62,5% de ces patients étaient pris en charge pour les interventions programmées. L’évaluation du risque anesthésique a montré que 91,9% des patients étaient de la classe ASA I et II. La chirurgie la plus pratiquée était viscérale (46,7%) suivie de la chirurgie gynéco-obstétricale (29,2%). Les différents types d'anesthésie étaient les suivants: anesthésie générale (87,6%), locorégionale (11,8%) et combinée (0,6%). Conclusion La pratique anesthésique dans la population d’étude était dominée par l'anesthésie générale. Les malades étaient au trois quart de sexe féminin et de la classe ASA I et II. Les résultats de cette étude indiquent la nécessité d’évaluer l'issue de cette pratique. La pratique anesthésique à Lubumbashi est tributaire du plateau technique, des compétences du personnel et de l'acceptabilité du type d'anesthésie par les patients. PMID:26523180

  5. Mise à jour technique sur la physiologie et l'évaluation du liquide amniotique.

    PubMed

    Lim, Kenneth I; Butt, Kimberly; Naud, Kentia; Smithies, Mila

    2017-01-01

    RéSULTATS: SOURCES DES DONNéES PROBANTES: Nous avons effectué une recherche sur MEDLINE et Kfinder pour trouver des articles pertinents, puis avons examiné les bibliographies des articles retenus, notamment des revues Cochrane et des articles de revue récents. Les données recueillies ont été analysées par le Comité d'imagerie diagnostique de la Société des obstétriciens et gynécologues du Canada. Les recommandations ont été classées selon les critères établis par le Groupe d'étude canadien sur les soins de santé préventifs (Tableau 1). AVANTAGES, DéSAVANTAGES ET COûTS: En obstétrique moderne, l'évaluation du volume de liquide amniotique par échographie fait partie intégrante de l'évaluation fœtale. Toute anomalie donne lieu à une intervention obstétricale et à des examens approfondis. Au Canada, il n'existe aucune définition normalisée associée à l'estimation du volume de liquide amniotique ni aucune approche d'évaluation uniforme. Plusieurs essais randomisés semblent indiquer que l'évaluation de poche unique, plutôt que de plusieurs poches (indice de liquide amniotique), diminue les interventions obstétricales sans augmenter l'incidence de résultats indésirables. La littérature récente laisse croire que des changements légers, mais détectables du liquide amniotique peuvent survenir une heure ou deux suivant des manœuvres physiologiques normales, ce qui pourrait expliquer la variabilité et le manque de cohérence des résultats d'évaluations répétées en peu de temps et ainsi créer de la confusion et donner lieu à d'autres examens. Le présent article vise à décrire les limites de l'évaluation du volume de liquide amniotique, à promouvoir une méthode d'évaluation normalisée et à proposer un ensemble commun de définitions. DéCLARATIONS SOMMAIRES: RECOMMANDATION. Copyright © 2017. Published by Elsevier Inc.

  6. Frequency Assignment, Sharing and Conservation in Systems (Aerospace). (l’Attribution, le partage et la conservation des frequences pour les systemes aeronautiques et spatiales)

    DTIC Science & Technology

    1999-01-01

    que pour les installations et le personnel mis ä sa disposition. T- l Technical Evaluation Report of the RTO...radiocommunications sur le radar, on peut mettre en oeuvre des techniques de Formation de Faisceau par le Calcul qui permettent d’augmenter encore le niveau...plus 6loign6s pouvant fonctionner sur les mSmes canaux de frequence que le radar sans g£ne mutuelle1. equipements de radiocommunication

  7. Trypanorhynch cestodes (Eutetrarhynchidae) from batoids along the coast of Argentina, including the description of new species in Dollfusiella Campbell et Beveridge, 1994 and Mecistobothrium Heinz et Dailey, 1974.

    PubMed

    Menoret, Adriana; Ivanov, Veronica A

    2015-09-07

    During a recent parasitological survey of elasmobranchs along the coast of Argentina, two new species of eutetrarhynchid cestodes of the genera Dollfusiella Campbell et Beveridge, 1994 and Mecistobothrium Heinz et Dailey, 1974 were collected from batoids. Dollfusiella acuta sp. n. was found in four arhynchobatid skates, i.e. Sympterygia acuta Garman (type host), Sympterygia bonapartii Müller et Henle, Atlantoraja castelnaui (Miranda Ribeiro) and Atlantoraja platana (Günther), and Mecistobothrium oblongum sp. n. in the eagle ray Myliobatis goodei Garman. Dollfusiella acuta sp. n. has a tentacular armature consisting of basal rows of uncinate hooks, a distinct basal swelling with uncinate, falcate and bill hooks, and a heteroacanthous metabasal armature with heteromorphous hooks (bothrial uncinate hooks and antibothrial falcate hooks), hooks 1(1') not separated, testes in two columns and an internal seminal vesicle. The tentacular armature of M. oblongum sp. n. is characterised by basal rows of uncinate hooks, a basal swelling with uncinate and falcate hooks, a typical heteroacanthous metabasal armature with heteromorphous hooks (uncinate and falcate to spiniform), and hooks 1(1') separated and of a constant size along the tentacle. It also possesses an elongate scolex, numerous testes arranged in 5-6 irregular columns, and an internal seminal vesicle. The discovery of M. oblongum in M. goodei represents the first record of species of Mecistobothrium in the southwestern Atlantic Ocean. An amended description of Dollfusiella cortezensis (Friggens et Duszynski, 2005) is also provided to clarify details of the scolex and tentacular armature. Members of Dollfusiella in the southwestern Atlantic are specific to a single host species or to a particular host family, while M. oblongum was found in a single host species. Although globally some plerocerci of eutetrarhynchids have been found in teleosts, extensive examination of teleosts off the coast of Argentina suggests

  8. Resolution of Behçet's syndrome associated pulmonary arterial aneurysms with infliximab.

    PubMed

    Schreiber, Benjamin E; Noor, Nadim; Juli, Christoph F; Haskard, Dorian O

    2011-12-01

    We describe the successful treatment of pulmonary arterial aneurysms in Behçet's syndrome using a tumor necrosis factor (TNF) inhibitor. A case is reported of Behçet's syndrome complicated by pulmonary arterial aneurysms that responded to anti-TNF therapy. This is accompanied by a literature review of previously published cases. We searched the English language medical literature using the PubMed and Medline search terms: "Behçet's," "Pulmonary aneurysms," and "infliximab," "etanercept," or "adalimumab." A 43-year-old man with a 6-month history of oral and genital ulcers, weight loss, and fatigue developed arterial aneurysms in the common carotid and common iliac arteries and thromboses in a femoral vein and pulmonary arteries. Treatment with high-dose oral corticosteroids and pulsed intravenous cyclophosphamide was initiated but while on treatment he developed pulmonary arterial aneurysms with hemoptysis. His treatment was changed to intravenous infliximab with methotrexate to which he showed a good response with marked clinical improvement, reduction in his inflammatory markers, and regression of the pulmonary arterial aneurysms. The review of the literature identified 3 reported cases of treatment of pulmonary arterial aneurysms in Behçet's syndrome with anti-TNF therapy, with good outcomes in each case. Pulmonary artery aneurysms are important complications of Behçet's syndrome. Anti-TNF inhibitors should be considered in patients who do not respond to treatment with corticosteroids and cyclophosphamide. Copyright © 2011 Elsevier Inc. All rights reserved.

  9. Le leadership en santé et la philosophie appliquée : une ressource essentielle.

    PubMed

    Fistein, Elizabeth; Malloy, David Cruise

    2017-07-01

    En qualité de professionnels de la santé, nous sommes déterminés à assurer l'exploitation efficiente et efficace de nos établissements. Les outils dont nous disposons sont les structures bureaucratiques, les règles, les règlements, les politiques et, bien sûr, les mesures. Il n'y a rien de foncièrement pernicieux à avoir des établissements efficients, efficaces et mesurés, mais nous soutenons que l'humanité et l'authenticité manquent cruellement dans cet environnement, au prix d'un travail significatif. Les solutions que nous proposons appartiennent au milieu de la philosophie, et particulièrement au secteur qui repose sur des principes fondamentaux : qu'est-ce qu'une infirmière, qu'est-ce qu'un patient, qu'est-ce qu'un hôpital?

  10. DERMAL DRUG LEVELS OF ANTIBIOTIC (CEPHALEXIN) DETERMINED BY ELECTROPORATION AND TRANSCUTANEOUS SAMPLING (ETS) TECHNIQUE

    PubMed Central

    Sammeta, SM; Vaka, SRK; Murthy, S. Narasimha

    2009-01-01

    The purpose of this project was to assess the validity of a novel “Electroporation and transcutaneous sampling (ETS)” technique for sampling cephalexin from the dermal extracellular fluid (ECF). This work also investigated the plausibility of using cephalexin levels in the dermal ECF as a surrogate for the drug level in the synovial fluid. In vitro and in vivo studies were carried out using hair less rats to assess the workability of ETS. Cephalexin (20mg/kg) was administered i.v. through tail vein and the time course of drug concentration in the plasma was determined. In the same rats, cephalexin concentration in the dermal ECF was determined by ETS and microdialysis techniques. In a separate set of rats, only intraarticular microdialysis was carried out determine the time course of cephalexin concentration in synovial fluid. The drug concentration in the dermal ECF determined by ETS and microdialysis did not differ significantly from each other and so as were the pharmacokinetic parameters. The results provide validity to the ETS technique. Further, there was a good correlation (~0.9) between synovial fluid and dermal ECF levels of cephalexin indicating that dermal ECF levels could be used as a potential surrogate for cephalexin concentration in the synovial fluid. PMID:19067398

  11. Continuous monitoring of evapotranspiration (ET) overview of LSA-SAF evapotranspiration products

    NASA Astrophysics Data System (ADS)

    Arboleda, A.; Ghilain, N.; Gellens-Meulenberghs, F.

    2017-10-01

    Evapotranspiration (ET) is the flux of water between the surface (vegetation, soil and water bodies) and the atmosphere. Monitoring this water loss may be of crucial importance for applications in hydrology, agriculture, water use efficiency studies and drought monitoring. We introduce one of the few satellite-based operational evapotranspiration products, generated continuously and in near real-time over Europe, Africa and part of South America. The ET products (30 minutes and daily) are generated at the EUMETSAT's Satellite Application Facility on Land Surface Analysis (LSA-SAF) operations centre (http://landsaf.ipma.pt). Following our commitments to our user's community, we are continuously looking for new ways to improve the product. To accomplish this, the feedback from users and potential users of the products is of great interest. In this contribution we present the ET products characteristics and recent improvements gained thanks to the inclusion in our ET algorithm of new variables derived from Earth observation by MSG SEVIRI. We show examples of the ET products and we highlight their potential in droughts detection and monitoring. Some examples of possible applications are presented to invite users and researchers to explore the possibilities offered by LSA-SAF evapotranspiration products.

  12. Air Pollution-Induced Vascular Dysfunction: Potential Role of Endothelin-1 (ET-1) System

    PubMed Central

    Finch, Jordan; Conklin, Daniel J.

    2015-01-01

    Exposure to air pollution negatively impacts cardiovascular health. Studies show that increased exposure to a number of airborne pollutants increases the risk for cardiovascular disease progression, myocardial events, and cardiovascular mortality. A hypothesized mechanism linking air pollution and cardiovascular disease is the development of systemic inflammation and endothelium dysfunction, the latter of which can result from an imbalance of vasoactive factors within the vasculature. Endothelin-1 (ET-1) is a potent peptide vasoconstrictor that plays a significant role in regulating vascular homeostasis. It has been reported that the production and function of ET-1 and its receptors are upregulated in a number of disease states associated with endothelium dysfunction including hypertension and atherosclerosis. This mini-review surveys epidemiological and experimental air pollution studies focused on ET-1 dysregulation as a plausible mechanism underlying the development of cardiovascular disease. Although alterations in ET-1 system components are observed in some studies, there remains a need for future research to clarify whether these specific changes are compensatory or causally related to vascular injury and dysfunction. Moreover, further research may test the efficacy of selective ET-1 pharmacological interventions (e.g., ETA receptor inhibitors) to determine whether these treatments could impede the deleterious impact of air pollution exposure on cardiovascular health. PMID:26148452

  13. Le consentement libre et éclairé aux soins en psychiatrie

    PubMed Central

    Neilson, Grainne; Chaimowitz, Gary

    2015-01-01

    Résumé Le patient a le droit d’être informé sur les soins de santé qui lui sont proposés et de participer activement à la prise de décisions relativement à ces soins. Le respect de la dignité et de l’autonomie de la personne passe par le respect de son droit de prendre des décisions à propos de ses soins psychiatriques, notamment de refuser un traitement, pour autant qu’elle soit apte à prendre des décisions. Il importe que le psychiatre connaisse les fondements éthiques du consentement libre et éclairé et les exigences prévues par le droit en cette matière, y compris la jurisprudence. Le consentement n’est pas immuable, pouvant changer avec le temps, au fil de l’évolution des conditions et des circonstances. Par conséquent, le consentement doit être un processus continu.

  14. Antagonism of Trichoderma harzianum ETS 323 on Botrytis cinerea mycelium in culture conditions.

    PubMed

    Cheng, Chi-Hua; Yang, Chia-Ann; Peng, Kou-Cheng

    2012-11-01

    ABSTRACT Previous studies have shown that the extracellular proteins of Trichoderma harzianum ETS 323 grown in the presence of deactivated Botrytis cinerea in culture include a putative l-amino acid oxidase and have suggested the involvement of this enzyme in the antagonistic mechanism. Here, we hypothesized that the mycoparasitic process of Trichoderma spp. against B. cinerea involves two steps; that is, an initial hyphal coiling stage and a subsequent hyphal coiling stage, with different coiling rates. The two-step antagonism of T. harzianum ETS 323 against B. cinerea during the mycoparasitic process in culture was evaluated using a biexponential equation. In addition, an l-amino acid oxidase (Th-l-AAO) was identified from T. harzianum ETS 323. The secretion of Th-l-AAO was increased when T. harzianum ETS 323 was grown with deactivated hyphae of B. cinerea. Moreover, in vitro assays indicated that Th-l-AAO effectively inhibited B. cinerea hyphal growth, caused cytosolic vacuolization in the hyphae, and led to hyphal lysis. Th-l-AAO also showed disease control against the development of B. cinerea on postharvest apple fruit and tobacco leaves. Furthermore, an apoptosis-like response, including the generation of reactive oxygen species, was observed in B. cinerea after treatment with Th-l-AAO, suggesting that Th-l-AAO triggers programmed cell death in B. cinerea. This may be associated with the two-step antagonism of T. harzianum ETS 323 against B. cinerea.

  15. Air Pollution-Induced Vascular Dysfunction: Potential Role of Endothelin-1 (ET-1) System.

    PubMed

    Finch, Jordan; Conklin, Daniel J

    2016-07-01

    Exposure to air pollution negatively impacts cardiovascular health. Studies show that increased exposure to a number of airborne pollutants increases the risk for cardiovascular disease progression, myocardial events, and cardiovascular mortality. A hypothesized mechanism linking air pollution and cardiovascular disease is the development of systemic inflammation and endothelium dysfunction, the latter of which can result from an imbalance of vasoactive factors within the vasculature. Endothelin-1 (ET-1) is a potent peptide vasoconstrictor that plays a significant role in regulating vascular homeostasis. It has been reported that the production and function of ET-1 and its receptors are upregulated in a number of disease states associated with endothelium dysfunction including hypertension and atherosclerosis. This mini-review surveys epidemiological and experimental air pollution studies focused on ET-1 dysregulation as a plausible mechanism underlying the development of cardiovascular disease. Although alterations in ET-1 system components are observed in some studies, there remains a need for future research to clarify whether these specific changes are compensatory or causally related to vascular injury and dysfunction. Moreover, further research may test the efficacy of selective ET-1 pharmacological interventions (e.g., ETA receptor inhibitors) to determine whether these treatments could impede the deleterious impact of air pollution exposure on cardiovascular health.

  16. Design of ET(B) receptor agonists: NMR spectroscopic and conformational studies of ET7-21[Leu7, Aib11, Cys(Acm)15].

    PubMed

    Hewage, Chandralal M; Jiang, Lu; Parkinson, John A; Ramage, Robert; Sadler, Ian H

    2002-03-01

    In a previous report we have shown that the endothelin-B receptor-selective linear endothelin peptide, ET-1[Cys (Acm)1,15, Ala3, Leu7, Aib11], folds into an alpha-helical conformation in a methanol-d3/water co-solvent [Hewage et al. (1998) FEBS Lett., 425, 234-238]. To study the requirements for the structure-activity relationships, truncated analogues of this peptide were subjected to further studies. Here we report the solution conformation of ET7-21[Leu7, Aib11, Cys(Acm)15], in a methanol-d3/water co-solvent at pH 3.6, by NMR spectroscopic and molecular modelling studies. Further truncation of this short peptide results in it displaying poor agonist activity. The modelled structure shows that the peptide folds into an alpha-helical conformation between residues Lys9-His16, whereas the C-terminus prefers no fixed conformation. This truncated linear endothelin analogue is pivotal for designing endothelin-B receptor agonists.

  17. New Insights in the Clinical Understanding of Behçet's Disease

    PubMed Central

    Cho, Sung Bin; Cho, Suhyun

    2012-01-01

    Behçet's disease is a chronic relapsing multisystemic inflammatory disorder characterized by four major symptoms (oral aphthous ulcers, genital ulcers, skin lesions, and ocular lesions) and occasionally by five minor symptoms (arthritis, gastrointestinal ulcers, epididymitis, vascular lesions, and central nervous system symptoms). Although the etiology of Behçet's disease is still unknown, there have been recent advances in immunopathogenic studies, genome-wide association studies, animal models, diagnostic markers, and new biological agents. These advances have improved the clinical understanding of Behçet's disease and have enabled us to develop new treatment strategies for this intractable disease, which remains one of the leading causes of blindness. PMID:22187230

  18. Systemes Fermioniques a Basse Dimension D'espace: Supraconductivite, Effet Hall Quantique et Statistique Fractionnaire

    NASA Astrophysics Data System (ADS)

    Sakhi, Said

    Cette these est constituee de trois sujets de recherche distincts. Les deux premiers articles traitent du phenomene de supraconductivite dans un modele bidimensionnel, dans le troisieme article on etudie l'action effective d'un systeme electronique soumis a l'effet d'un champ magnetique (systeme de Hall) et le dernier article examine la quantification d'un systeme de particules identiques en deux dimensions d'espace et la possibilite des anyons. Le modele qu'on analyse dans les deux premiers articles est un systeme fermionique dont les particules chargees et de masse nulle interagissent entre elles avcc un couplage attractif et fort. L'analyse de l'action effective decrivant la physique a basse energie nous permet d'examiner la structure de l'espace de phase. A temperature nulle, le parametre d'ordre du systeme prend une valeur moyenne non nulle. Consequemment, la symetrie continue U(1) du modele est spontanement brisee et il en resulte l'apparition d'un mode de Goldstone. En presence d'un champ electromagnetique externe, ce mode disparait et le champ de jauge acquiert une masse donc l'effet Meissner caracteristique d'un supraconducteur. Bien que le modele ne soit pas renormalisable dans le sens perturbatif, on montre qu'il l'est dans le cadre du developpement en 1/N ou N est le nombre d'especes fermioniques. En outre, on montre que l'inclusion des effets thermiques change radicalement le mecanisme de supraconductivite. En effet, on montre que la brisure spontanee de la symetrie U(1) n'est plus possible a temperature finie a cause de tres severes divergences infrarouges. Par contre, la dynamique des tourbillons (vortex) existant dans le plan devient essentielle. On montre que le phenomene de supraconductivite resulte du confinement de ces objets topologiques et que la temperature critique s'identifie a celle de Kosterlitz -Thouless. Ce mecanisme de supraconductivite presente l'avantage d'aboutir a un rapport gap a la temperature critique plus eleve que celui du

  19. Electronic and geometric properties of ETS-10: QM/MM studies of cluster models.

    PubMed

    Zimmerman, Anne Marie; Doren, Douglas J; Lobo, Raul F

    2006-05-11

    Hybrid DFT/MM methods have been used to investigate the electronic and geometric properties of the microporous titanosilicate ETS-10. A comparison of finite length and periodic models demonstrates that band gap energies for ETS-10 can be well represented with relatively small cluster models. Optimization of finite clusters leads to different local geometries for bulk and end sites, where the local bulk TiO6 geometry is in good agreement with recent experimental results. Geometry optimizations reveal that any asymmetry within the axial O-Ti-O chain is negligible. The band gap in the optimized model corresponds to a O(2p) --> Tibulk(3d) transition. The results suggest that the three Ti atom, single chain, symmetric, finite cluster is an effective model for the geometric and electronic properties of bulk and end TiO6 groups in ETS-10.

  20. "Extracting" the key fragment in ETS-10 crystallization and its application in AM-6 assembly.

    PubMed

    Guo, Meiling; Feng, Zhaochi; Li, Guanna; Hofmann, Jan P; Pidko, Evgeny A; Magusin, Pieter C M M; Guo, Qiang; Weckhuysen, Bert M; Hensen, Emiel J M; Fan, Fengtao; Li, Can

    2012-09-17

    The mechanism of crystallization of microporous titanosilicate ETS-10 was investigated by Raman spectroscopy combined with (29)Si magic-angle spinning (MAS) NMR spectroscopy, DFT calculations, and SEM imaging. The formation of three-membered ring species is shown to be the key step in the hydrothermal synthesis of ETS-10. They are formed by means of a complex process that involves the interaction of silicate species in the reaction mixture, which promotes the dissolution of TiO(2) particles. These insights into the mechanism of ETS-10 growth led to the successful development of a new synthesis route to the vanadosilicate AM-6 that involves the use of intermediates that contain three-membered ring species as an initiator. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Synthesis and characterization of microporous titanosilicate ETS-10 obtained with different Ti sources

    SciT

    Casado, Clara; Amghouz, Zakariae; Garcia, Jose R.

    2009-06-03

    Titanosilicate ETS-10 crystals were prepared by hydrothermal synthesis varying Ti source (TiCl{sub 3} and commercial TiO{sub 2}-anatase), time in autoclave and seeding with previously prepared ETS-10 crystals. The crystalline powders were characterized by X-ray diffraction, N{sub 2} adsorption, thermogravimetric analysis, and scanning and transmission electron microscopies. Control of the particle size of ETS-10 crystals ranging from 0.32 {mu}m x 0.41 {mu}m to 16.4 {mu}m x 32.5 {mu}m was successfully achieved varying the seeding and synthesis conditions. In particular, it was found that the use of TiO{sub 2}-anatase alone or together with TiCl{sub 3} promotes heterogeneous primary nucleation. Transmission electron microscopymore » demonstrated that the largest crystals obtained here were twinned.« less

  2. Correspondence regarding Zhong et al., BMC Bioinformatics 2013 Mar 7;14:89.

    PubMed

    Kuhn, Alexandre

    2014-11-28

    Computational expression deconvolution aims to estimate the contribution of individual cell populations to expression profiles measured in samples of heterogeneous composition. Zhong et al. recently proposed Digital Sorting Algorithm (BMC Bioinformatics 2013 Mar 7;14:89) and showed that they could accurately estimate population-specific expression levels and expression differences between two populations. They compared DSA with Population-Specific Expression Analysis (PSEA), a previous deconvolution method that we developed to detect expression changes occurring within the same population between two conditions (e.g. disease versus non-disease). However, Zhong et al. compared PSEA-derived specific expression levels across different cell populations. Specific expression levels obtained with PSEA cannot be directly compared across different populations as they are on a relative scale. They are accurate as we demonstrate by deconvolving the same dataset used by Zhong et al. and, importantly, allow for comparison of population-specific expression across conditions.

  3. Association of myasthenia gravis and Behçet's disease: A case report.

    PubMed

    Kisabay, Aysin; Sari, Ummu Serpil; Boyaci, Recep; Batum, Melike; Yilmaz, Hikmet; Selcuki, Deniz

    2016-01-01

    Myasthenia gravis is a disease of neuromuscular junction due to auto-immune destruction of the acetylcholine receptors. Behçet's disease, on the other hand, is a multisystemic vascular-inflammatory disease. Both conditions are not common in the general population although their association has not been reported in the literature. We wanted to present our patient who developed clinical course of myasthenia gravis following discontinuation of medications due to complications of corticosteroid for Behçet's disease. It was observed that clinical findings of myasthenia gravis recovered following restarting steroid treatment and he did not experience attacks of both conditions. Although Myasthenia gravis and Behçet's disease are distinct entities clinically as well as in terms of pathogenesis, they share common physiopathological features and their treatment is based on their common features. Copyright © 2016 Polish Neurological Society. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

  4. STS-45 external tank (ET) falls back to Earth after jettisoning from OV-104

    1992-03-24

    STS045-71-001 (24 March 1992) --- This 70mm photograph of the external fuel tank (ET) for STS-45 was photographed 4 1/2 minutes after having been jettisoned from Space Shuttle Atlantis. The excellent view of the starboard side of the ET shows both top and bottom attach points to the two solid rocket boosters (SRB). NASA engineers studying the STS-45 onboard photography deem the visible burn scars, caused by the SRBs, to be normal. The long thin pipe visible is the liquid oxygen line. At the bottom end of the large tank, both the liquid oxygen (nearest camera) and liquid hydrogen orbiter-to-ET attach hardware can be seen.

  5. Endovascular aneurysm exclusion along a femorodistal venous bypass in active Behçet's disease.

    PubMed

    Gretener, Silvia B; Do, Dai-Do; Baumgartner, Iris; Dinkel, Hans-Peter; Schmidli, Jürg; Birrer, Manuela

    2002-10-01

    To report the endovascular repair of dual aneurysms along a femorodistal venous bypass graft in a patient with Behçet's disease. A 55-year-old man of middle European ancestry with Behçet's disease had dual aneurysms evolve along the proximal segment of a femorodistal venous bypass that had been implanted 2.5 years earlier for recurrent false aneurysm formation. Owing to the lack of suitable venous conduits and the active nature of the disease, the aneurysms were successfully excluded with overlapping Hemobahn and Jostent endografts; the immunosuppressive therapy was intensified. Rupture of the aneurysms was successfully prevented, but the stent-grafts thrombosed 6 weeks later owing to exacerbation of the underlying disease. Endovascular exclusion of aneurysm in venous bypass grafts in Behçet's disease is feasible. Although the stent-grafts thrombosed, they did prevent rupture of the aneurysms.

  6. Reply to comments by Riley and Dunlop on He et al. (2015)

    Bence, James R.; Madenjian, Charles P.; He, Ji X.; Fielder, David G.; Pothoven, Steven A.; Dobiesz, Norine E.; Johnson, James E.; Ebener, Mark P.; Cottrill, R. Adam; Mohr, Lloyd C.; Koproski, Scott R.

    2016-01-01

    He et al. (2015) described piscivory patterns in the main basin of Lake Huron 1984-2010, during which there was also a pattern of stepwise declines in the abundance of dominant prey fish species. The approach of He et al. (2015) was to couple age-structured stock assessment and fish bioenergetics models to estimate prey fish consumption, and to compare these patterns with prey fish biomass from a bottom trawl survey. Riley and Dunlop (2015) were highly critical of the methods and conclusions reached by He et al. (2015). They claimed that we incorrectly interpreted the bottom trawl survey data, and did not account for uncertainty. We respond to these and other criticisms below, which we find do not undermine our findings.

  7. Mesure Objective De L'attenuation et De L'effet D'occlusion Des Protecteurs Auditifs a Partir Des Potentiels Evoques Stationnaires et Multiples =

    NASA Astrophysics Data System (ADS)

    Valentin, Olivier

    Selon l'Organisation mondiale de la sante, le nombre de travailleurs exposes quotidiennement a des niveaux de bruit prejudiciables a leur audition est passe de 120 millions en 1995 a 250 millions en 2004. Meme si la reduction du bruit a la source devrait etre toujours privilegiee, la solution largement utilisee pour lutter contre le bruit au travail reste la protection auditive individuelle. Malheureusement, le port des protecteurs auditifs n'est pas toujours respecte par les travailleurs car il est difficile de fournir un protecteur auditif dont le niveau d'attenuation effective est approprie a l'environnement de travail d'un individu. D'autre part, l'occlusion du canal auditif induit une modification de la perception de la parole, ce qui cree un inconfort incitant les travailleurs a retirer leurs protecteurs. Ces deux problemes existent parce que les methodes actuelles de mesure de l'effet d'occlusion et de l'attenuation sont limitees. Les mesures objectives basees sur des mesures microphoniques intra-auriculaires ne tiennent pas compte de la transmission directe du son a la cochlee par conduction osseuse. Les mesures subjectives au seuil de l'audition sont biaisees a cause de l'effet de masquage aux basses frequences induit par le bruit physiologique. L'objectif principal de ce travail de these de doctorat est d'ameliorer la mesure de l'attenuation et de l'effet d'occlusion des protecteurs auditifs intra-auriculaires. L'approche generale consiste a : (i) verifier s'il est possible de mesurer l'attenuation des protecteurs auditifs grâce au recueil des potentiels evoques stationnaires et multiples (PEASM) avec et sans protecteur auditif (protocole 1), (ii) adapter cette methodologie pour mesurer l'effet d'occlusion induit par le port de protecteur auditifs intra-auriculaires (protocole 2), et (iii) valider chaque protocole par l'intermediaire de mesures realisees sur sujets humains. Les resultats du protocole 1 demontrent que les PEASM peuvent etre utilises pour

  8. La prévention de l’étouffement et de la suffocation chez les enfants

    PubMed Central

    Cyr, Claude

    2012-01-01

    RÉSUMÉ L’étouffement, la suffocation et la strangulation sont responsables de graves blessures non intentionnelles chez les enfants et constituent des causes importantes de décès non intentionnels chez les nourrissons et les tout-petits. Presque la totalité des décès et des blessures attribuables à un étouffement, une suffocation ou une strangulation sont évitables. Le présent document de principes traite des définitions, de l’épidémiologie et des stratégies de prévention efficaces de ces blessures. Des recommandations qui combinent des démarches pour améliorer la sécurité, incluant des recherches, de la surveillance, des lois et des normes, la conception des produits et l’éducation, sont présentées. Les dispensateurs de soins pédiatriques devraient encourager les parents et autres personnes qui s’occupent d’enfants à apprendre la réanimation cardiorespiratoire (RCR) et les premiers soins en cas d’étouffement, et leur offrir des conseils préventifs adaptés à l’âge de leur enfant lors des bilans de santé réguliers afin de prévenir ces blessures.

  9. Heart-Rate Recovery Index Is Impaired in Behçet's Disease

    PubMed Central

    Kaya, Ergun Baris; Yorgun, Hikmet; Akdogan, Ali; Ates, Ahmet Hakan; Canpolat, Ugur; Sunman, Hamza; Aytemir, Kudret; Tokgozoglu, Lale; Kabakci, Giray; Calguneri, Meral; Ozkutlu, Hilmi; Oto, Ali

    2009-01-01

    Behçet's disease, a multisystemic inflammatory disorder, has been associated with a number of cardiovascular dysfunctions, including ventricular arrhythmias and sudden cardiac death. Heart-rate recovery after exercise can provide both an estimate of impaired parasympathetic tone and a prognosis in regard to all-cause and cardiovascular death. The aim of our study was to evaluate heart-rate recovery in Behçet's disease From January through July 2008, we examined at our outpatient clinic and prospectively enrolled 30 consecutive patients with Behçet's disease and 50 healthy control participants who were matched for age and sex. Basal electrocardiography, echocardiography, and treadmill exercise testing were performed in all patients and control participants. The heart-rate recovery index was calculated in the usual manner, by subtracting the 1st-minute (Rec1), 2nd-minute (Rec2), and 3rd-minute (Rec3) recovery heart rates from the maximal heart rate after exercise stress testing. Patients with Behçet's disease exhibited significantly lower heart-rate recovery numbers, compared with healthy control participants: Rec1, 24.28 ± 8.2 vs 34.4 ± 7.6, P = 0.002; Rec2, 49.28 ± 11.2 vs 57.5 ± 7.0, P < 0.05; and Rec3, 56.2 ± 12.11 vs 67.4 ± 8.7, P = 0.014. To our knowledge, this is the 1st study that shows an impaired heart-rate recovery index (indicative of reduced parasympathetic activity) among patients with Behçet's disease. Given the independent prognostic value of the heart-rate recovery index, our results may explain the increased occurrence of arrhythmias and sudden cardiac death in Behçet's patients. Therefore, this index may be clinically useful in the identification of high-risk patients. PMID:19693299

  10. The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder.

    PubMed

    Williams, Michael J; Klockars, Anica; Eriksson, Anders; Voisin, Sarah; Dnyansagar, Rohit; Wiemerslage, Lyle; Kasagiannis, Anna; Akram, Mehwish; Kheder, Sania; Ambrosi, Valerie; Hallqvist, Emilie; Fredriksson, Robert; Schiöth, Helgi B

    2016-06-01

    Several reports suggest obesity and bipolar disorder (BD) share some physiological and behavioural similarities. For instance, obese individuals are more impulsive and have heightened reward responsiveness, phenotypes associated with BD, while bipolar patients become obese at a higher rate and earlier age than people without BD; however, the molecular mechanisms of such an association remain obscure. Here we demonstrate, using whole transcriptome analysis, that Drosophila Ets96B, homologue of obesity-linked gene ETV5, regulates cellular systems associated with obesity and BD. Consistent with a role in obesity and BD, loss of nervous system Ets96B during development increases triacylglyceride concentration, while inducing a heightened startle-response, as well as increasing hyperactivity and reducing sleep. Of notable interest, mouse Etv5 and Drosophila Ets96B are expressed in dopaminergic-rich regions, and loss of Ets96B specifically in dopaminergic neurons recapitulates the metabolic and behavioural phenotypes. Moreover, our data indicate Ets96B inhibits dopaminergic-specific neuroprotective systems. Additionally, we reveal that multiple SNPs in human ETV5 link to body mass index (BMI) and BD, providing further evidence for ETV5 as an important and novel molecular intermediate between obesity and BD. We identify a novel molecular link between obesity and bipolar disorder. The Drosophila ETV5 homologue Ets96B regulates the expression of cellular systems with links to obesity and behaviour, including the expression of a conserved endoplasmic reticulum molecular chaperone complex known to be neuroprotective. Finally, a connection between the obesity-linked gene ETV5 and bipolar disorder emphasizes a functional relationship between obesity and BD at the molecular level.

  11. Methodes iteratives paralleles: Applications en neutronique et en mecanique des fluides

    NASA Astrophysics Data System (ADS)

    Qaddouri, Abdessamad

    Dans cette these, le calcul parallele est applique successivement a la neutronique et a la mecanique des fluides. Dans chacune de ces deux applications, des methodes iteratives sont utilisees pour resoudre le systeme d'equations algebriques resultant de la discretisation des equations du probleme physique. Dans le probleme de neutronique, le calcul des matrices des probabilites de collision (PC) ainsi qu'un schema iteratif multigroupe utilisant une methode inverse de puissance sont parallelises. Dans le probleme de mecanique des fluides, un code d'elements finis utilisant un algorithme iteratif du type GMRES preconditionne est parallelise. Cette these est presentee sous forme de six articles suivis d'une conclusion. Les cinq premiers articles traitent des applications en neutronique, articles qui representent l'evolution de notre travail dans ce domaine. Cette evolution passe par un calcul parallele des matrices des PC et un algorithme multigroupe parallele teste sur un probleme unidimensionnel (article 1), puis par deux algorithmes paralleles l'un mutiregion l'autre multigroupe, testes sur des problemes bidimensionnels (articles 2--3). Ces deux premieres etapes sont suivies par l'application de deux techniques d'acceleration, le rebalancement neutronique et la minimisation du residu aux deux algorithmes paralleles (article 4). Finalement, on a mis en oeuvre l'algorithme multigroupe et le calcul parallele des matrices des PC sur un code de production DRAGON ou les tests sont plus realistes et peuvent etre tridimensionnels (article 5). Le sixieme article (article 6), consacre a l'application a la mecanique des fluides, traite la parallelisation d'un code d'elements finis FES ou le partitionneur de graphe METIS et la librairie PSPARSLIB sont utilises.

  12. Risk assessment for heart disease and workplace ETS exposure among nonsmokers.

    PubMed

    Steenland, K

    1999-12-01

    In 1994 the U.S. Occupational Health and Safety Administration (OSHA) published a study of risk assessment for heart disease and lung cancer resulting from workplace exposure to environmental tobacco smoke (ETS) among nonsmokers. This assessment is currently being revised. The present article considers different possible approaches to a risk assessment for heart disease among nonsmokers resulting from workplace ETS exposure, reviews the approach taken by OSHA in 1994, and suggests some modifications to that approach. Since 1994 the literature supporting an association between ETS exposure and heart disease among never smokers (sometimes including long-term former smokers) has been strengthened by new studies, including some studies that have specifically considered workplace exposure. A number of these studies are appropriate for inclusion in a meta-analysis, whereas a few may not be due to methodological problems or problems in exposure definition. A meta-analysis of eight relative risks (either rate ratios or odds ratios) for heart disease resulting from workplace ETS exposure, based on one reasonable selection of appropriate studies, yields a combined relative risk of 1.21 (95% confidence interval [CI], 1.04-1.41). This relative risk, which is similar to that used by OSHA in 1994, yields an excess risk of death from heart disease by age 70 of 7 per 1000 (95% CI 0.001-0.013) resulting from ETS exposure in the workplace. This excess risk exceeds OSHA's usual threshold for regulation of 1 per 1000. Approximately 1,710 excess ischemic heart disease deaths per year would be expected among nonsmoking U.S. workers 35-69 years of age exposed to workplace ETS.

  13. Risk assessment for heart disease and workplace ETS exposure among nonsmokers.

    PubMed Central

    Steenland, K

    1999-01-01

    In 1994 the U.S. Occupational Health and Safety Administration (OSHA) published a study of risk assessment for heart disease and lung cancer resulting from workplace exposure to environmental tobacco smoke (ETS) among nonsmokers. This assessment is currently being revised. The present article considers different possible approaches to a risk assessment for heart disease among nonsmokers resulting from workplace ETS exposure, reviews the approach taken by OSHA in 1994, and suggests some modifications to that approach. Since 1994 the literature supporting an association between ETS exposure and heart disease among never smokers (sometimes including long-term former smokers) has been strengthened by new studies, including some studies that have specifically considered workplace exposure. A number of these studies are appropriate for inclusion in a meta-analysis, whereas a few may not be due to methodological problems or problems in exposure definition. A meta-analysis of eight relative risks (either rate ratios or odds ratios) for heart disease resulting from workplace ETS exposure, based on one reasonable selection of appropriate studies, yields a combined relative risk of 1.21 (95% confidence interval [CI], 1.04-1.41). This relative risk, which is similar to that used by OSHA in 1994, yields an excess risk of death from heart disease by age 70 of 7 per 1000 (95% CI 0.001-0.013) resulting from ETS exposure in the workplace. This excess risk exceeds OSHA's usual threshold for regulation of 1 per 1000. Approximately 1,710 excess ischemic heart disease deaths per year would be expected among nonsmoking U.S. workers 35-69 years of age exposed to workplace ETS. PMID:10592143

  14. Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression

    PubMed Central

    Lu, Xiaoming; Zoller, Erin E.; Weirauch, Matthew T.; Wu, Zhiguo; Namjou, Bahram; Williams, Adrienne H.; Ziegler, Julie T.; Comeau, Mary E.; Marion, Miranda C.; Glenn, Stuart B.; Adler, Adam; Shen, Nan; Nath, Swapan K.; Stevens, Anne M.; Freedman, Barry I.; Tsao, Betty P.; Jacob, Chaim O.; Kamen, Diane L.; Brown, Elizabeth E.; Gilkeson, Gary S.; Alarcón, Graciela S.; Reveille, John D.; Anaya, Juan-Manuel; James, Judith A.; Sivils, Kathy L.; Criswell, Lindsey A.; Vilá, Luis M.; Alarcón-Riquelme, Marta E.; Petri, Michelle; Scofield, R. Hal; Kimberly, Robert P.; Ramsey-Goldman, Rosalind; Joo, Young Bin; Choi, Jeongim; Bae, Sang-Cheol; Boackle, Susan A.; Graham, Deborah Cunninghame; Vyse, Timothy J.; Guthridge, Joel M.; Gaffney, Patrick M.; Langefeld, Carl D.; Kelly, Jennifer A.; Greis, Kenneth D.; Kaufman, Kenneth M.; Harley, John B.; Kottyan, Leah C.

    2015-01-01

    Genetic variants at chromosomal region 11q23.3, near the gene ETS1, have been associated with systemic lupus erythematosus (SLE), or lupus, in independent cohorts of Asian ancestry. Several recent studies have implicated ETS1 as a critical driver of immune cell function and differentiation, and mice deficient in ETS1 develop an SLE-like autoimmunity. We performed a fine-mapping study of 14,551 subjects from multi-ancestral cohorts by starting with genotyped variants and imputing to all common variants spanning ETS1. By constructing genetic models via frequentist and Bayesian association methods, we identified 16 variants that are statistically likely to be causal. We functionally assessed each of these variants on the basis of their likelihood of affecting transcription factor binding, miRNA binding, or chromatin state. Of the four variants that we experimentally examined, only rs6590330 differentially binds lysate from B cells. Using mass spectrometry, we found more binding of the transcription factor signal transducer and activator of transcription 1 (STAT1) to DNA near the risk allele of rs6590330 than near the non-risk allele. Immunoblot analysis and chromatin immunoprecipitation of pSTAT1 in B cells heterozygous for rs6590330 confirmed that the risk allele increased binding to the active form of STAT1. Analysis with expression quantitative trait loci indicated that the risk allele of rs6590330 is associated with decreased ETS1 expression in Han Chinese, but not other ancestral cohorts. We propose a model in which the risk allele of rs6590330 is associated with decreased ETS1 expression and increases SLE risk by enhancing the binding of pSTAT1. PMID:25865496

  15. Fabrication et caracterisation de nanocristaux de silicium localises, realises par gravure electrochimique pour des applications nanoelectroniques

    NASA Astrophysics Data System (ADS)

    Ayari-Kanoun, Asma

    Ce travail de these porte sur le developpement d'une nouvelle approche pour la localisation et l'organisation de nanocristaux de silicium realises par gravure electrochimique. Cette derniere represente une technique simple et peu couteuse par rapport aux autres techniques couramment utilisees pour la fabrication de nanocristaux de silicium. L'idee de ce travail a ete d'etudier la nanostructuration de minces couches de nitrure de silicium, d'environ 30 nm d'epaisseur pour permettre par la suite un arrangement periodique des nanocristaux de silicium. Cette pre-structuration est obtenue de facon artificielle en imposant un motif periodique via une technique de lithographie par faisceau d'electrons combinee avec une gravure plasma. Une optimisation des conditions de lithographie et de gravure plasma ont permis d'obtenir des reseaux de trous de 30 nm de diametre debouchant sur le silicium avec un bon controle de leur morphologie (taille, profondeur et forme). En ajustant les conditions de gravure electrochimique (concentration d'acide, temps de gravure et densite de courant), nous avons obtenu des reseaux -2D ordonnes de nanocristaux de silicium de 10 nm de diametre a travers ces masques de nanotrous avec le controle parfait de leur localisation, la distance entre les nanocristaux et leur orientation cristalline. Des etudes electriques preliminaires sur ces nanocristaux ont permis de mettre en evidence des effets de chargement. Ces resultats tres prometteurs confirment l'interet des nanocristaux de silicium realises par gravure electrochimique dans le futur pour la fabrication a grande echelle de dispositifs nanoelectroniques. Mots-cles : localisation, organisation, nanocristaux de silicium, gravure electrochimique, lithographie electronique, gravure plasma, nitrure de silicium.

  16. Le profil clinique et immunologique de 15 patients Marocains atteints de syndrome hyper IgM

    PubMed Central

    Ouair, Hind; Benhsaien, Ibtihal; Jeddane, Leila; El Bakkouri, Jalila; Elhafidi, Naima; Rada, Noureddine; Najib, Jilali; Ailal, Fatima; Alj, Hanane Salih; Bousfiha, Ahmed Aziz

    2017-01-01

    Le Syndrome hyper IgM est un déficit immunitaire héréditaire bien connu, décrit pour la première fois en 1961. Il est causé par un défaut au niveau des lymphocytes B, caractérisé par un taux sérique normal ou élevé des IgM et un taux bas ou nul des IgG, IgA, IgE résultant d'une déficience de la commutation isotypique. Ses manifestations cliniques sont dominées par les infections à répétition, surtout du tube digestif, de la sphère ORL et des poumons. Le syndrome est causé par un défaut de commutation de classe d'immunoglobuline dans les cellules B, et une diminution de la capacité des monocytes à induire la prolifération des lymphocytes T. Le résultat net de tous ces défauts est la susceptibilité accrue aux infections opportunistes à Pneumocystis jiroveci, Cryptosporidium spp et d'autres organismes intracellulaires, ainsi qu'une fréquence élevée d'infections bactériennes et virales. L'intérêt de ce projet est d'illustrer l'importance de la compréhension des mécanismes physiopathologiques associés à cette susceptibilité accrue aux infections, ce qui permettra une meilleure prise en charge diagnostique et thérapeutique des patients atteint du Syndrome hyper IgM (SHIM). PMID:28690727

  17. Epaisseur de l'intima-média carotidienne et facteurs de risque cardio-vasculaires

    PubMed Central

    Herinirina, Nicolas Fanantenana; Rajaonarison, Lova Hasina Ny Ony Narindra; Herijoelison, Andry Roussel; Ahmad, Ahmad

    2015-01-01

    Introduction L’épaisseur intima-média de la carotide commune mesurée à l’échographie est un marqueur de risque cardio-vasculaire. L'objectif de ce travail est d’établir la corrélation entre l’épaisseur de l'intima-média carotidienne commune et les facteurs de risque cardio-vasculaire chez des sujets asymptomatiques. Méthodes Etude transversale descriptive et analytique portant sur 77 sujets de 40 ans et plus chez qui nous avons évalué les facteurs de risque cardio-vasculaire et analysé leur association avec l’épaisseur intima-média carotidienne commune. Résultats L’épaisseur intima-média augmentait avec l’âge. Les hommes avaient une épaisseur intima-média plus marquée que les femmes. L'hypertension artérielle, le diabète et la dyslipidémie sont corrélés à l’épaisseur de l'intima-média contrairement au tabagisme. Conclusion L’âge élevé et le sexe masculin sont les facteurs déterminants de la majoration de l’épaisseur intima-média carotidienne commune surtout si s'ajoutent l'hypertension artérielle, le diabète ou la dyslipidémie. PMID:26327990

  18. Ruxolitinib vs best available therapy for ET intolerant or resistant to hydroxycarbamide.

    PubMed

    Harrison, Claire N; Mead, Adam J; Panchal, Anesh; Fox, Sonia; Yap, Christina; Gbandi, Emmanouela; Houlton, Aimee; Alimam, Samah; Ewing, Joanne; Wood, Marion; Chen, Frederick; Coppell, Jason; Panoskaltsis, Nicki; Knapper, Steven; Ali, Sahra; Hamblin, Angela; Scherber, Robyn; Dueck, Amylou C; Cross, Nicholas C P; Mesa, Ruben; McMullin, Mary Frances

    2017-10-26

    Treatments for high-risk essential thrombocythemia (ET) address thrombocytosis, disease-related symptoms, as well as risks of thrombosis, hemorrhage, transformation to myelofibrosis, and leukemia. Patients resistant/intolerant to hydroxycarbamide (HC) have a poor outlook. MAJIC (ISRCTN61925716) is a randomized phase 2 trial of ruxolitinib (JAK1/2 inhibitor) vs best available therapy (BAT) in ET and polycythemia vera patients resistant or intolerant to HC. Here, findings of MAJIC-ET are reported, where the modified intention-to-treat population included 58 and 52 patients randomized to receive ruxolitinib or BAT, respectively. There was no evidence of improvement in complete response within 1 year reported in 27 (46.6%) patients treated with ruxolitinib vs 23 (44.2%) with BAT ( P = .40). At 2 years, rates of thrombosis, hemorrhage, and transformation were not significantly different; however, some disease-related symptoms improved in patients receiving ruxolitinib relative to BAT. Molecular responses were uncommon; there were 2 complete molecular responses (CMR) and 1 partial molecular response in CALR- positive ruxolitinib-treated patients. Transformation to myelofibrosis occurred in 1 CMR patient, presumably because of the emergence of a different clone, raising questions about the relevance of CMR in ET patients. Grade 3 and 4 anemia occurred in 19% and 0% of ruxolitinib vs 0% (both grades) in the BAT arm, and grade 3 and 4 thrombocytopenia in 5.2% and 1.7% of ruxolitinib vs 0% (both grades) of BAT-treated patients. Rates of discontinuation or treatment switching did not differ between the 2 trial arms. The MAJIC-ET trial suggests that ruxolitinib is not superior to current second-line treatments for ET. This trial was registered at www.isrctn.com as #ISRCTN61925716. © 2017 by The American Society of Hematology.

  19. Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743)

    PubMed Central

    Erba, E; Bergamaschi, D; Bassano, L; Ronzoni, S; Liberti, G Di; Muradore, I; Vignati, S; Faircloth, G; Jimeno, J; D'Incalci, M

    2000-01-01

    By exposing Igrov-1 human ovarian cancer cells to increasing concentrations of Ecteinascidin-743 (ET-743), either for a short or prolonged time, we obtained sublines resistant to ET-743 which overexpress Pgp. The most resistant clone (Igrov-1/25 ET) was evaluated for biological and pharmacological characterizations. The increased Pgp levels of Igrov-1/25 ET were not due to amplification of the mdr-1 gene but to increased mRNA levels. No increase in other multidrug resistance-related proteins such as MRP or LRP was observed in Igrov-1/25 ET. The IC50values of ET-743 against Igrov-1/25 ET was approximately 50 times higher than the parental cell line. Resistance was not reversed while maintaining the cell line in drug-free medium for at least 24 months. Igrov-1/25 ET was cross-resistant to Doxorubicin and VP16 while it was equally sensitive to L-PAM, MNNG, CPT and only marginally less sensitive to Cis-DDP and Oxaliplatin compared to the parental cell line. Igrov-1/25 ET exposed to Doxorubicin retained this drug much less, mainly because of a more efficient drug efflux. The cyclosporine analogue SDZ PSC-833 reversed the resistance of Igrov-1/25 ET to ET-743, without any enhancement of the drug activity against the parental Igrov-1 cell line. Igrov-1/25 ET exhibits typical features of cell lines overexpressing the mdr-1 gene and can be a potentially useful tool in selecting ET-743 non-cross-resistant analogues as well as to investigate methods to counteract resistance to this drug. © 2000 Cancer Research Campaign PMID:10817511

  20. Endothelin-1 and ET receptors impair left ventricular function by mediated coronary arteries dysfunction in chronic intermittent hypoxia rats.

    PubMed

    Wang, Jin-Wei; Li, Ai-Ying; Guo, Qiu-Hong; Guo, Ya-Jing; Weiss, James W; Ji, En-Sheng

    2017-01-01

    Obstructive sleep apnea (OSA) results in cardiac dysfunction and vascular endothelium injury. Chronic intermittent hypoxia (CIH), the main characteristic of OSAS, is considered to be mainly responsible for cardiovascular system impairment. This study is aimed to evaluate the role of endothelin-1(ET-1) system in coronary injury and cardiac dysfunction in CIH rats. In our study, Sprague-Dawley rats were exposed to CIH (FiO 2 9% for 1.5 min, repeated every 3 min for 8 h/d, 7 days/week for 3 weeks). After 3 weeks, the left ventricular developed pressure (LVDP) and coronary resistance (CR) were measured with the langendorff mode in isolated hearts. Meanwhile, expressions of ET-1 and ET receptors were detected by immunohistochemical and western blot, histological changes were also observed to determine effects of CIH on coronary endothelial cells. Results suggested that decreased LVDP level combined with augmented coronary resistance was exist in CIH rats. CIH could induce endothelial injury and endothelium-dependent vasodilatation dysfunction in the coronary arteries. Furthermore, ET-1 and ET A receptor expressions in coronary vessels were increased after CIH exposure, whereas ET B receptors expression was decreased. Coronary contractile response to ET-1 in both normoxia and CIH rats was inhibited by ET A receptor antagonist BQ123. However, ET B receptor antagonist BQ788 enhanced ET-1-induced contractile in normoxia group, but had no significant effects on CIH group. These results indicate that CIH-induced cardiac dysfunction may be associated with coronary injury. ET-1 plays an important role in coronary pathogenesis of CIH through ET A receptor by mediating a potent vasoconstrictor response. Moreover, decreased ET B receptor expression that leads to endothelium-dependent vasodilatation decline, might be also participated in coronary and cardiac dysfunction. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The