Obituary: David Stanley Evans, 1916-2004

NASA Astrophysics Data System (ADS)

Bash, Frank N.

2005-12-01

headquartered in Cape Town, South Africa. David had designed and built a Newtonian spectrograph for the 74-inch Radcliffe Telescope with which he measured the first southern galaxy redshifts. David and his family spent 1965-66 in Austin, Texas, where he was a National Science Foundation Senior Visiting Scientist at the University of Texas and McDonald Observatory. They moved permanently to Austin in 1968 and David became a Professor of Astronomy and Associate Director of McDonald Observatory at the University of Texas at Austin. At McDonald Observatory, R. E. Nather had devised a high-speed photometer capable of measuring millisecond time-scale changes in brightness and with Brian Warner, he invented "high-speed astronomy". This instrument caused Evans to revive his occultation program and, over the next twenty years, he produced the major part of the angular diameters of late-type stars with his students and collaborators. In addition, David and collaborators used the extensive collections of the University of Texas to write "Herschel at the Cape". David was also involved in observing the occultation of ? Sco by Jupiter in 1972 and in observing, during a solar eclipse in 1973, the gravitational deflections in the positions of stars whose light passes near to the Sun. The eclipse was observed from Mauritania, and the observations confirmed Einstein's prediction again. David Evans and his students studied late-type stars that have large star-spots and others that flare. In addition, they studied stars whose lunar occultation observations had revealed them to be double or even more than two stars. David Evans's major scientific contribution was an application of his stellar angular diameters to deduce the surface brightness of stars with the result that with suitable color indices one could use photometry to deduce the angular diameter of stars. This is applicable to stars which can never be occulted by the Moon, and its application to Cepheid variable stars has yielded their

Delinquent Medical Service Accounts at David Grant Air Force Medical Center Need Additional Management Oversight

DTIC Science & Technology

2015-09-24

No. DODIG-2015-179 S E P T E M B E R 2 4 , 2 0 1 5 Delinquent Medical Service Accounts at David Grant Air Force Medical Center Need Additional...us at www.dodig.mil Results in Brief Delinquent Medical Service Accounts at David Grant Air Force...Force Medical Center (DGMC) properly managed delinquent accounts over 180 days by effectively transferring the debt to the appropriate debt collection

Letter Report - Verification Survey of Final Grids at the David Witherspoon, Inc. 1630 Site Knoxville, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

P.C. Weaver

2009-02-17

Conduct verification surveys of grids at the DWI 1630 Site in Knoxville, Tennessee. The independent verification team (IVT) from ORISE, conducted verification activities in whole and partial grids, as completed by BJC. ORISE site activities included gamma surface scans and soil sampling within 33 grids; G11 through G14; H11 through H15; X14, X15, X19, and X21; J13 through J15 and J17 through J21; K7 through K9 and K13 through K15; L13 through L15; and M14 through M16

David Scott

NASA Technical Reports Server (NTRS)

1975-01-01

Dr. David R. Scott was appointed Director of NASA's Flight Research Center on April 18, 1975. From August 1973 he served as Deputy Director of FRC and was appointed acting director in January 1975. He is retired from the U.S. Air Force where he held the rank of Colonel. Dave left the NASA Dryden Flight Research Center on October 30, 1977 after the Center had been renamed in honor of Hugh L. Dryden. As a NASA astronaut, Scott flew on Gemini 8, Apollo 9 and was spacecraft commander of Apollo 15. When he left the astronaut corps in 1972, Scott was named Technical Assistant to the Apollo Program Manager at Johnson Space Center in Houston. Later he served as Special Assistant for Mission Operations and Government Funded Equipment. Dave earned a Bachelor of Science Degree from the United States Military Academy in 1954, standing fifth in a class of 633, and the degrees of Bachelor and Master of Science in Aeronautics and Astronautics from the Massachusetts Institute of Technology (MIT) in 1962. He was awarded an Honorary Doctorate of Astronautical Science from the University of Michigan in 1971. Dave has graduated from the Air Force Experimental Test Pilot School and Aerospace Research Pilot School. He has over 5,600 hours flying time along with 20 hours of extra vehicular activity (EVA) time. Dr. Scott is a Fellow of the American Astronautical Society; Associate Fellow of the American Institute of Aeronautics and Astronautics; a member of the Society of Experimental Test Pilots, Tau Beta Pi, Sigma Xi, and Sigma Gamma Tau. Among Dr. Scott's special honors are two NASA Distinguished Service Medals, the NASA Exceptional Service Medal, two Air Force Distinguished Service Medals, the Air Force Distinguished Flying Cross, the Air Force Association's David C. Schilling Trophy, and the Robert J. Collier Trophy for 1971.

David L. Parkhurst as the recipient of the 2012 O.E. Meinzer Award of the Hydrogeology Division of the Geological Society of America

USGS Publications Warehouse

Glynn, Pierre D.

2012-01-01

Describes the impact of USGS scientist David Parkhurst's influential contributions to the fields of aqueous geochemistry and hydrogeology. Parkhurst is the recipient of the 2012 O.E. Meinzer award of the Geological Society of America's Hydrogeology Division.

Toxinotyping of Clostridium perfringens fecal isolates of reintroduced Père David's deer (Elaphurus davidianus) in China.

PubMed

Qiu, Huiling; Chen, Fu; Leng, Xinyan; Fei, Rongmei; Wang, Libo

2014-10-01

Clostridium perfringens is an important pathogen causing sudden death syndrome, necrotic enteritis, and gas gangrene in ruminants, especially some deer species. Père David's deer (Elaphurus davidianus) is one of the world's rare species and is an endangered and protected species in China. Some Père David's deer in the Chinese Shishou Père David's Deer Preserve died due to C. perfringens infection. We investigated the toxin types and C. perfringens enterotoxin-positive (cpe(+)) strains of isolated C. perfringens in Père David's deer in China. We collected 155 fecal samples from the Beijing Nanhaizi Père David's Deer Park and the Jiangsu Dafeng Père David's Deer National Nature Reserve between July 2010 and July 2011. Bacteria isolated using blood agar and mannitol agar plates were identified by Gram staining and nested PCR for 16S rRNA. We isolated C. perfringens from 41 fecal samples and used PCR amplification of five toxin genes to identify the toxinotypes and the cpe(+) strains of C. perfringens. Twenty-one isolates were type A, 15 were type E, and five were type D. Fifteen isolates were cpe(+) strains, including eight that were type A and seven that were type E.

Region 9: California South Coast Adequate Letter (4/18/2003)

EPA Pesticide Factsheets

This is a letter from Jack Broadbent, Director, to Catherine Witherspoon regarding the motor vehicle emissions budgets in the particulate matter (PM-10) progress and attainment plan and motor vehicle emissions budgets for the South Coast.

Region 9: California Los Angeles (Coachella) Adequate Letter (4/18/2003)

EPA Pesticide Factsheets

This is a letter from Jack Broadbent, Director, to Catherine Witherspoon regarding Coachella Valley's transportation conformity motor vehicle emissions budgets in the particulate matter (PM-10) progress and attainment plan and motor vehicle emissions

Sixteen-Year Experience of David and Bentall Procedures in Acute Type A Aortic Dissection.

PubMed

Yang, Bo; Patel, Himanshu J; Sorek, Claire; Hornsby, Whitney E; Wu, Xiaoting; Ward, Sarah; Thomas, Marc; Driscoll, Anisa; Waidley, Victoria A; Norton, Elizabeth L; Likosky, Donald S; Deeb, G Michael

2018-03-01

To examine short-term and midterm outcomes after the David and Bentall procedures in patients with an acute type A aortic dissection. Between 2001 and 2017, patients (n = 135) with acute type A aortic dissection underwent an aortic root replacement with either the David (n = 40) or Bentall (n = 95) procedure. Perioperative outcome, reoperation rate, aortic valve function, and long-term survival were evaluated. The median age of the entire cohort was 56 years. Rates of malperfusion (21%), shock (16%), history of renal failure (4%), and extent of surgery were similar between David and Bentall groups. However, the David group was significantly younger (45 versus 61 years) with less hypertension (45% versus 66%), coronary artery disease (0% versus 17%), valvulopathy (5% versus 19%), and prior cardiac surgery (5% versus 21%). Overall operative mortality was 9.6% (David 3% and Bentall 13%). Composite outcome comprising myocardial infarction, stroke, new-onset renal failure, and operative mortality was 18% in the entire cohort (David 5% and Bentall 23%). In the David group, the freedom of moderate aortic insufficiency was 95% at 10 years. The rate of reoperation for pathology of the proximal aorta or aortic valve was 0% and 2% for the David and Bentall groups, respectively. Ten-year Kaplan-Meier survival was 66% (95% confidence interval: 51% to 77%) for the entire cohort, with 98% (95% confidence interval: 84% to 99%) survival in the David group and 57% (95% confidence interval: 42% to 70%) survival in the Bentall group. Both the David and Bentall procedures are appropriate surgical approaches for aortic root replacement in select patients with an acute type A aortic dissection. Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

David Gordon Campbell Robertson: A Biographical Sketch

NASA Astrophysics Data System (ADS)

See, J. B.

Emeritus Professor David Robertson of the Missouri University of Science and Technology was born in Dublin Ireland on 29 December 1941. His father was a merchant navy Captain who served during WWII and during David's early years his family lived in Dublin and Donegal where David went to the local elementary school. In 1954 he moved to London with his parents and attended Highgate School before commencing metallurgy at the Royal School of Mines, Imperial College, London in 1960.

Distributed Access View Integrated Database (DAVID) system

NASA Technical Reports Server (NTRS)

Jacobs, Barry E.

1991-01-01

The Distributed Access View Integrated Database (DAVID) System, which was adopted by the Astrophysics Division for their Astrophysics Data System, is a solution to the system heterogeneity problem. The heterogeneous components of the Astrophysics problem is outlined. The Library and Library Consortium levels of the DAVID approach are described. The 'books' and 'kits' level is discussed. The Universal Object Typer Management System level is described. The relation of the DAVID project with the Small Business Innovative Research (SBIR) program is explained.

David Goldwasser | NREL

Science.gov Websites

. Prior to joining NREL, David worked in architectural design, 3D modeling, and interactive media. He consulted for Google on 3D modeling tools and worked in Colorado on sustainable architecture projects

Heterogeneous distributed query processing: The DAVID system

NASA Technical Reports Server (NTRS)

Jacobs, Barry E.

1985-01-01

The objective of the Distributed Access View Integrated Database (DAVID) project is the development of an easy to use computer system with which NASA scientists, engineers and administrators can uniformly access distributed heterogeneous databases. Basically, DAVID will be a database management system that sits alongside already existing database and file management systems. Its function is to enable users to access the data in other languages and file systems without having to learn the data manipulation languages. Given here is an outline of a talk on the DAVID project and several charts.

"Handbook of biomedical optics", edited by David A. Boas, Constantinos Pitris, and Nimmi Ramanujam

PubMed Central

2012-01-01

David A. Boas, Constantinos Pitris, and Nimmi Ramanujam, Eds.: Handbook of Biomedical Optics CRC Press, Taylor and Francis Group, Boca Raton, London, New York, 2011 ISBN: 978-1-4200-9036-9 (Hardback), 787 pages

A tribute to David Triggle.

PubMed

Moos, Walter H

2015-11-15

"A gentleman and a scholar" is how many would characterize David Triggle. His insightful, thoughtful approaches to professional pursuits, both personal research and collaborative relationships, stand out by any measure. He has shaped students, colleagues, and whole fields, calcium ion channels and ligands being most representative of the latter. In recent years, he has expanded his contributions to important commentaries on politics and social challenges in the sciences. David is the rare intellect able to do all this and more, as outlined herein. Copyright © 2015 Elsevier Inc. All rights reserved.

Second Annual David Derse Memorial Lecture and Award | Poster

Cancer.gov

By Anne Arthur, Guest Writer The Second Annual David Derse Memorial Lecture and Award presentation was held on November 12, 2013, at the NCI at Frederick Conference Center to honor David Derse’s outstanding research accomplishments and to stimulate the exchange of innovative ideas that Derse was well known for promoting throughout his scientific career. The Annual David Derse

David L. Harrison: A Work Of Art

ERIC Educational Resources Information Center

Raymond, Allen

2005-01-01

This article describes poet and writer David L. Harrison. A former School Board Chairman from Springfield, MO, David was responsible for beginning an annual "Teacher Appreciation Banquet" and for launching the "Sky High for Reading" program. The "Sky High for Reading" program encourages children in Springfield to read enough books so that, if…

David Macaulay's Pyramid.

ERIC Educational Resources Information Center

Frew, Andrew W.

1997-01-01

Integrating literature and mathematics can be meaningful using David Macaulay's "Pyramid." This article provides an annotated bibliography of picture books, fiction, folk tales, nonfiction, videotapes, audio books, and CD-ROMs for grades 1-12 to support a unit on Egypt. Describes related math activities; and highlights a catalog of…

David Snowberg | NREL

Science.gov Websites

the management of blade test projects. He also works with the NREL Marine Hydrokinetic group in the areas of risk management and failure analysis. David is a registered Professional Engineer in Arizona within the discipline of mechanical engineering; he is also a certified Project Management Professional

Astronaut David R. Scott on deck of ship prior to water egress training

NASA Image and Video Library

1968-11-05

S68-54810 (5 Nov. 1968) --- Astronaut David R. Scott, command module pilot of the Apollo 9 (Spacecraft 104/Lunar Module 3/Saturn 504) space mission, relaxes on the deck of the NASA Motor Vessel Retriever prior to participating in water egress training in the Gulf of Mexico.

It's All about the Process: Talking with David and Cecelia Diaz.

ERIC Educational Resources Information Center

Giorgis, Cyndi

1999-01-01

Interviews David and Cecelia Diaz about David's work as an award-winning illustrator of children's books, their successful illustration/design business, and David's other artistic pursuits. Discusses his illustrating process and its evolution, and the impact of the Caldecott Award. (SR)

INTRODUCTION: David Sherrington as a mentor of young scientists

NASA Astrophysics Data System (ADS)

Goldbart, Paul M.

2008-08-01

How deeply honoured I am to have the opportunity to express my thoughts at this delightful celebration of David's achievements, so far, in his remarkable career. I have been asked to center my remarks on David's contributions to the mentoring and professional development of scientists early in their careers. This is a topic that I am more than happy to reflect on, because it gives me the opportunity to recall the exciting period I spent as one of David's postgraduate students at Imperial College in the early 1980s. It also gives me the chance to publicly express my gratitude to David for the opportunities he created for me at that time, as well as for the interest and care he has shown in my career and well-being ever since, as we have met up and exchanged news and ideas around the world: in New Mexico and Colorado, in Cancun, Paris and Trieste, at numerous March Meetings of the American Physical Society and, of course in London, Oxford, and my home town, Champaign-Urbana, location of the University of Illinois. I have been a member of David's circle for 25 years now, and I would like to tell you a little about how this came to be. Not because of what this says about me, but, rather, because of what it tells you about David and the rich generosity of his spirit and effort when it comes to supporting the underdog. I was indeed one such underdog—and that's putting it charitably—when I first met David in September of 1982, not long before the academic year was to begin. I had heard about the exciting circle of physical and mathematical ideas swirling around the spin glass question during the previous year, which I had spent at the University of California's Los Angeles campus, through an opportunity kindly arranged, as it happens, by Sam Edwards. But I was eager to return to the UK for postgraduate studies and to work on spin glasses, so I simply showed up at David's Imperial College office, unannounced (if I remember correctly). And with his characteristic

Dr. David Sawyer, Mickey Mouse and Dr. David Brown attend a ceremony at Ronald McNair Middle School

NASA Technical Reports Server (NTRS)

1999-01-01

Dr. David Sawyer (left), Superintendent of the Brevard County School District, Mickey Mouse, and Dr. David Brown, a NASA astronaut, attend a tribute to NASA astronaut Ronald McNair held in the gymnasium of Ronald McNair Magnet School in Cocoa, Fla. During the tribute, Walt Disney World presented a portrait of McNair to the school, which had previously been renamed for the fallen astronaut. McNair was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

Meet David, Our Teacher's Helper.

ERIC Educational Resources Information Center

Newell, William; And Others

1984-01-01

DAVID, Dynamic Audio Video Instructional Device, is composed of a conventional videotape recorder, a microcomputer, and a video controller, and has been successfully used for speech reading and sign language instruction with deaf students. (CL)

76 FR 7837 - Magill, David W.; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-3723-002] Magill, David W.; Notice of Filing Take notice that on February 4, 2011, David W. Magill submitted for filing, an application for authority to hold interlocking positions, pursuant to section 305(b) of the Federal Power Act...

14. 1862 LITHOGRAPH SHOWING ST. DAVID'S CHURCH IN WINTER SCENE. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. 1862 LITHOGRAPH SHOWING ST. DAVID'S CHURCH IN WINTER SCENE. Photocopied from George Smith's book, History of Delaware County, Penna., 1862 - St. David's Church (Episcopal), Valley Forge Road (Newtown Township), Wayne, Delaware County, PA

DAVID-WS: a stateful web service to facilitate gene/protein list analysis.

PubMed

Jiao, Xiaoli; Sherman, Brad T; Huang, Da Wei; Stephens, Robert; Baseler, Michael W; Lane, H Clifford; Lempicki, Richard A

2012-07-01

The database for annotation, visualization and integrated discovery (DAVID), which can be freely accessed at http://david.abcc.ncifcrf.gov/, is a web-based online bioinformatics resource that aims to provide tools for the functional interpretation of large lists of genes/proteins. It has been used by researchers from more than 5000 institutes worldwide, with a daily submission rate of ∼1200 gene lists from ∼400 unique researchers, and has been cited by more than 6000 scientific publications. However, the current web interface does not support programmatic access to DAVID, and the uniform resource locator (URL)-based application programming interface (API) has a limit on URL size and is stateless in nature as it uses URL request and response messages to communicate with the server, without keeping any state-related details. DAVID-WS (web service) has been developed to automate user tasks by providing stateful web services to access DAVID programmatically without the need for human interactions. The web service and sample clients (written in Java, Perl, Python and Matlab) are made freely available under the DAVID License at http://david.abcc.ncifcrf.gov/content.jsp?file=WS.html.

Second Annual David Derse Memorial Lecture and Award | Poster

Cancer.gov

By Anne Arthur, Guest Writer The Second Annual David Derse Memorial Lecture and Award presentation was held on November 12, 2013, at the NCI at Frederick Conference Center to honor David Derse’s outstanding research accomplishments and to stimulate the exchange of innovative ideas that Derse was well known for promoting throughout his scientific career. The Annual David Derse Memorial Lecture and Award is sponsored by the HIV Drug Resistance Program, with support from Hye Kyung Chung-Derse, Ph.D., the National Cancer Institute (NCI), the Foundation for the National Institutes of Health (NIH), and colleagues and friends of Derse who contributed to the memorial fund in his honor.

Education, Educational Research, and the "Grammar" of Understanding: A Response to David Bridges

ERIC Educational Resources Information Center

Smeyers, Paul

2009-01-01

This article is the author's response to a paper presented by David Bridges. Bridges' central question: "Is there something exclusive and superior about insider understanding which the outsider cannot understand?" is indeed not only crucial to the contexts he explicitly deals with, i.e. religious understanding, ethnographic research and…

Electron-Rich Carboranes. Studies of a Stereochemically Novel System, (CH3)4C4B7H9, and 11-Vertex Arachno Cluster.

DTIC Science & Technology

1981-01-01

FINSTER , R N GRIMES NOGOIR-75C-0305 UNCLASSIFIED TR-37 NL EOMEEEhE OFFICE OF NAVAL RESEARCH CONTRACT NO. i14.-7-C-31 q,4 TECHNICAL REPORT NO. 37L" 0...Electron-Rich Carboranes. Studies of a Stereochemically Novel System, (CH") 4C4 BH 9 , an 11-Vertex Arachno Cluster. .) David C./ Finster aad Russell N...System, (CH3 )4C4B7H9 , an l-Vertex Arachno Cluster 1 David C. Finster and Russell N. Grimes* Contribution from the Department of Chemistry University of

David Gale: Restless Pioneer

ERIC Educational Resources Information Center

Meyer, Walter

2006-01-01

David Gale was one of the mathematicians responsible for the modern form of the theory of duality in linear programming and the associated proof of the minimax theorem in the theory of games. He is a member of the National Academy of Sciences and is Professor Emeritus of Mathematics and Operations Research at the University of California at…

Interview with David Moore

ERIC Educational Resources Information Center

Rossman, Allan; Dietz, E. Jacquelin; Moor, David

2013-01-01

David Moore is Professor Emeritus of Statistics at Purdue University. He served as the first President of the International Association for Statistical Education (IASE) from 1993-1995 and as President of the American Statistical Association (ASA) in 1998. He is a Fellow of the ASA and of the IMS and was awarded the ASA's Founders Award in…

Third Annual David Derse Memorial Lecture and Award | Poster

Cancer.gov

By Anne Arthur, Guest Writer The Third Annual David Derse Memorial Lecture and Award presentation was held on Nov. 18 at NCI at Frederick to honor the outstanding research accomplishments of David Derse, Ph.D., and to stimulate the exchange of innovative ideas that Derse was well known for promoting throughout his scientific career.

DAVID-WS: a stateful web service to facilitate gene/protein list analysis

PubMed Central

Jiao, Xiaoli; Sherman, Brad T.; Huang, Da Wei; Stephens, Robert; Baseler, Michael W.; Lane, H. Clifford; Lempicki, Richard A.

2012-01-01

Summary: The database for annotation, visualization and integrated discovery (DAVID), which can be freely accessed at http://david.abcc.ncifcrf.gov/, is a web-based online bioinformatics resource that aims to provide tools for the functional interpretation of large lists of genes/proteins. It has been used by researchers from more than 5000 institutes worldwide, with a daily submission rate of ∼1200 gene lists from ∼400 unique researchers, and has been cited by more than 6000 scientific publications. However, the current web interface does not support programmatic access to DAVID, and the uniform resource locator (URL)-based application programming interface (API) has a limit on URL size and is stateless in nature as it uses URL request and response messages to communicate with the server, without keeping any state-related details. DAVID-WS (web service) has been developed to automate user tasks by providing stateful web services to access DAVID programmatically without the need for human interactions. Availability: The web service and sample clients (written in Java, Perl, Python and Matlab) are made freely available under the DAVID License at http://david.abcc.ncifcrf.gov/content.jsp?file=WS.html. Contact: xiaoli.jiao@nih.gov; rlempicki@nih.gov PMID:22543366

Teaching Students about the Environment with Henry David Thoreau

ERIC Educational Resources Information Center

Curriculum Review, 2008

2008-01-01

"Walden: The Ballad of Thoreau" is a two-act four-character play about the final two days writer Henry David Thoreau spent in his cabin before leaving Walden Pond. Teachers can use this play to teach about preserving the earth to students. This article presents a brief synopsis of the play and a brief biography of Henry David Thoreau.

Independent Verification Final Summary Report for the David Witherspoon, Inc. 1630 Site Knoxville, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

P.C. Weaver

2009-04-29

The primary objective of the independent verification was to determine if BJC performed the appropriate actions to meet the specified “hot spot” cleanup criteria of 500 picocuries per gram (pCi/g) uranium-238 (U-238) in surface soil. Specific tasks performed by the independent verification team (IVT) to satisfy this objective included: 1) performing radiological walkover surveys, and 2) collecting soil samples for independent analyses. The independent verification (IV) efforts were designed to evaluate radioactive contaminants (specifically U-238) in the exposed surfaces below one foot of the original site grade, given that the top one foot layer of soil on the site wasmore » removed in its entirety.« less

A Reply from David Elkind.

ERIC Educational Resources Information Center

Elkind, David

1989-01-01

Replying to Robert H. Anderson's article in the same "Principal" issue, David Elkind defends his article against classroom rotation. Elkind strongly favors multiage grouping and team teaching, but views the real issue as departmentalization and rotation versus self-contained classrooms. Although multiage grouping and team teaching are…

David Livingstone's uvulectomy.

PubMed

Larner, A J

2006-05-01

In April 1852 in Cape Town, South Africa, Dr David Livingstone, then 39 years of age and yet to commence the explorations of Africa which would bring him to public attention, underwent the surgical procedure of uvulectomy. This article reviews the history of Livingstone's uvulectomy and its indications and outcome, as documented by his own writings. The practice of uvulectomy in indigenous African societies and some contemporary ideas about uvulectomy are also considered in order to try to ascertain why Livingstone elected to undergo this procedure.

Speaking Personally--With David Foster

ERIC Educational Resources Information Center

American Journal of Distance Education, 2010

2010-01-01

David Foster is the founder of Kryterion, an Internet test administration company, and currently serves there as chief scientist and executive vice president. He is the author of numerous articles for industry trade journals and textbooks and sits on the Council for the International Test Commission. In this interview, Foster talks about his…

A Conversation with...David Satcher.

ERIC Educational Resources Information Center

Campbell, Neil A.

1996-01-01

David Satcher began his career as a medical geneticist and was appointed director of the Centers for Disease Control and Prevention (CDC) in 1993. In this interview, Dr. Satcher talks about the responsibilities of the CDC and explains how a childhood experience inspired his interest in medicine and his continuing commitment to community service.…

David L. Gutmann (1925-2013).

PubMed

Rose, Jon; Huyck, Margaret; Grunes, Jerome

2014-01-01

David L. Gutmann, a pioneer in geropsychology and professor emeritus at Northwestern University, died on November 3, 2013, at the age of 88. A student of Bernice Neugarten, Bruno Bettelheim, and Erik Erikson, Gutmann discovered changes in adult psychological development related to parenting styles that held across diverse cultures. 2014 APA, all rights reserved

76 FR 14388 - David Creasey; Notice of Application Tendered for Filing With the Commission, Accepted for Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-16

... No.: 13829-001. c. Date filed: February 4, 2011. d. Applicant: David Creasey. e. Name of Project... on private property owned by the applicant. h. Filed Pursuant to: 18 CFR 4.61 of the Commission's.... FERC Contact: Ryan Hansen, (202) 502-8074, or e-mail at ryan.hansen@ferc.gov . k. A copy of the...

Astronaut David Brown talks to FIRST team members

NASA Technical Reports Server (NTRS)

2000-01-01

Astronaut David Brown talks with FIRST team members, Baxter Bomb Squad, from Mountain Home High School, Mountain Home, Ariz., during the FIRST competition. Students from all over the country are at the KSC Visitor Complex for the FIRST (For Inspiration and Recognition of Science and Technology) Southeast Regional competition March 9-11 in the Rocket Garden. Teams of high school students are testing the limits of their imagination using robots they have designed, with the support of business and engineering professionals and corporate sponsors, to compete in a technological battle against other schools' robots. Of the 30 high school teams competing, 16 are Florida teams co-sponsored by NASA and KSC contractors. Local high schools participating are Astronaut, Bayside, Cocoa Beach, Eau Gallie, Melbourne, Melbourne Central Catholic, Palm Bay, Rockledge, Satellite, and Titusville.

ISS ULF2 Flight Control Team in FCR-1 - Orbit 3 - Flight Director David Korth

NASA Image and Video Library

2009-03-20

JSC2009-E-061164 (20 March 2009) --- The members of the STS-119/15A ISS Orbit 3 flight control team pose for a group portrait in the space station flight control room in the Mission Control Center at NASA’s Johnson Space Center. Flight director David Korth (right) is visible on the front row.

Interview with Dr. David H. Kalsbeek

ERIC Educational Resources Information Center

Sauter, David M.

2005-01-01

David H. Kalsbeek currently is vice president for enrollment management at DePaul University in Chicago, Illinois. In that capacity, he leads the marketing and enrollment development strategies for the nation's largest and fastest-growing Catholic university, enrolling 23,000 students in eight colleges and six campuses throughout the greater…

42 CFR 52e.9 - Additional conditions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Additional conditions. 52e.9 Section 52e.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.9 Additional conditions. The Director...

42 CFR 52e.9 - Additional conditions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Additional conditions. 52e.9 Section 52e.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.9 Additional conditions. The Director...

42 CFR 52e.9 - Additional conditions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Additional conditions. 52e.9 Section 52e.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.9 Additional conditions. The Director...

42 CFR 52e.9 - Additional conditions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Additional conditions. 52e.9 Section 52e.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.9 Additional conditions. The Director...

42 CFR 52e.9 - Additional conditions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Additional conditions. 52e.9 Section 52e.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.9 Additional conditions. The Director...

David Ben-Gurion: A Creative Leader

ERIC Educational Resources Information Center

Rosemarin, Shoshana

2014-01-01

David Ben-Gurion (1886-1973), the first Prime Minister of Israel, is included in Pasternak's (2001) list of the nine most memorable leaders of the twentieth century. All of them are remembered for the reforms they initiated. Roosevelt (USA), Stalin (Russia), Castro (Cuba), and Thatcher (England) focused on social-economical changes, whereas Gandhi…

Speaking Personally--With Mark David Milliron

ERIC Educational Resources Information Center

American Journal of Distance Education, 2008

2008-01-01

This article presents an interview with Mark David Milliron, board chair of the Institute for the Study of Knowledge Management in Education, a trustee with Western Governors University, and a member of the advisory board for the University of Texas (UT) TeleCampus. He is also president and CEO of Catalyze Learning International, a private…

Motion of David Glacier in East Antarctica Observed by COSMO-SkyMed Differential SAR Interferometry

NASA Astrophysics Data System (ADS)

Han, H.; Lee, H.

2011-12-01

David glacier, located in Victoria Land, East Antarctica (75°20'S, 161°15'E), is an outlet glacier of 13 km width near the grounding line and 50 km long from the source to the grounding line. David glacier flows into Ross Sea forming Drygalski Ice Tongue, 100 km long and 23 km wide. In this study, we extracted a surface displacement map of David by applying differential SAR interferometry (DInSAR) to one-day tandem pairs obtained from COSMO-SkyMed satellites on April 28-29 (descending orbit) and May 5-6 (ascending orbit), 2011, respectively. Terra ASTER global digital elevation model (GDEM) is used to remove the topographic effect from the COSMO-SkyMed interferograms. David glacier showed maximum displacement of 35 cm during April 28-29 and 20 cm during May 5-6 in the direction of radar line of sight. The glacier can be divided into several blocks by the disparities of displacement between the different sliding zone. Surface displacement map contains errors originated from orbit data, atmospheric conditions, DEM error. GDEM is generated from the ASTER optical images acquired from 2000 to 2008. It has the vertical accuracy of about 20 m at 95% confidence with the 30 m of horizontal posting. The accuracy of GDEM reduces when cloud cover is included in the ASTER image. Particularly in the snow and ice area, GDEM is inaccurate due to whiteout effect during stereo matching. The inaccuracy of GDEM could be a reason of the observed glacier motion in the opposite direction of gravity. This problem can be solved by using TanDEM-X DEM. Bistatic acquisition of SAR images from the constellation of TerraSAR-X and TanDEM-X will generate a global DEM with the vertical accuracy better than 2 m and the horizontal posting of 12 m. We plan to perform DInSAR of COSMO-SkyMed one-day tandem pairs again when the high-accuracy TanDEM-X DEM is available in the near future. As a conclusion, we could analyze the displacement of David glacier in East Antarctica. The glacier showed very fast

78 FR 36591 - David M. Lewis, D.M.D., Dismissal of Proceeding

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-18

... DEPARTMENT OF JUSTICE Drug Enforcement Administration David M. Lewis, D.M.D., Dismissal of Proceeding On December 5, 2012, the Deputy Assistant Administrator, Office of Diversion Control, Drug Enforcement Administration (DEA), issued an Order to Show Cause to David M. Lewis, D.M.D. (Registrant), of Sacramento, California. The Show Cause Order...

Building Consensus toward a Shared Purpose: A Profile of President David Gray

ERIC Educational Resources Information Center

Dessoff, Alan

2011-01-01

The author presents a profile of APPA president David Gray. One might say that David Gray's path into higher education facilities management was anything but traditional. Today, Gray is the assistant vice president of facilities services at Middle Tennessee State University. His professional career, however, actually began in banking. In 1993 he…

Portrait - Apollo 9

NASA Image and Video Library

1969-02-23

S69-25478 (23 Feb. 1969) --- These three astronauts are the prime crew of the Apollo 9 Earth-orbital space mission. Left to right, are Russell L. Schweickart, lunar module pilot; David R. Scott, command module pilot; and James A. McDivitt, commander. In the right background is the Apollo 9 space vehicle on Pad A, Launch Complex 39, Kennedy Space Center (KSC). They are pausing momentarily during training for their scheduled 10-day mission.

Discussion of David Thissen's Bad Questions: An Essay Involving Item Response Theory

ERIC Educational Resources Information Center

Wainer, Howard

2016-01-01

The usual role of a discussant is to clarify and correct the paper being discussed, but in this case, the author, Howard Wainer, generally agrees with everything David Thissen says in his essay, "Bad Questions: An Essay Involving Item Response Theory." This essay expands on David Thissen's statement that there are typically two principal…

Attitudes of Mississippi College Students toward David Duke before and after Seeing the Film "Who Is David Duke?"

ERIC Educational Resources Information Center

Eisenman, Russell; And Others

1993-01-01

Investigated attitudes of 211 college students in Mississippi before and after viewing film "Who Is David Duke?" which provided evidence of Duke's current racism, anti-Semitism, and pro-Nazi leanings. Previous study with students in Louisiana, majority did not change attitudes after viewing film. In present study, students' attitudes…

Apollo 9 Mission image - Lunar Module

NASA Image and Video Library

1969-03-07

AS09-21-3183 (7 March 1969) --- A view of the Apollo 9 Lunar Module (LM) "Spider" in a lunar landing configuration, as photographed from the Command and Service Modules (CSM) on the fifth day of the Apollo 9 Earth-orbital mission. The landing gear on the "Spider" has been deployed. Lunar surface probes (sensors) extend out from the landing gear foot pads. Inside the "Spider" were astronauts James A. McDivitt, Apollo 9 commander; and Russell L. Schweickart, lunar module pilot. Astronaut David R. Scott, command module pilot, remained at the controls in the Command Module (CM), "Gumdrop," while the other two astronauts checked out the LM. Schweickart, lunar module pilot, is photographed from the CM "Gumdrop" during his extravehicular activity (EVA) on the fourth day of the Apollo 9 Earth-orbital mission. The CSM is docked with the LM. Astronaut James A. McDivitt, Apollo 9 commander, was inside the LM "Spider." Astronaut David R. Scott, command module pilot, remained at the controls in the CM.

Apollo 9 Mission image - Lunar Module

NASA Image and Video Library

1969-03-07

AS09-21-3197 (7 March 1969) --- A view of the Apollo 9 Lunar Module (LM) "Spider" in a lunar landing configuration, as photographed from the Command and Service Modules (CSM) on the fifth day of the Apollo 9 Earth-orbital mission. The landing gear on the "Spider" has been deployed. Lunar surface probes (sensors) extend out from the landing gear foot pads. Inside the "Spider" were astronauts James A. McDivitt, Apollo 9 commander; and Russell L. Schweickart, lunar module pilot. Astronaut David R. Scott, command module pilot, remained at the controls in the Command Module (CM), "Gumdrop," while the other two astronauts checked out the LM. Schweickart, lunar module pilot, is photographed from the CM "Gumdrop" during his extravehicular activity (EVA) on the fourth day of the Apollo 9 Earth-orbital mission. The CSM is docked with the LM. Astronaut James A. McDivitt, Apollo 9 commander, was inside the LM "Spider." Astronaut David R. Scott, command module pilot, remained at the controls in the CM.

Astronaut David Brown poses with ComBBat team

NASA Technical Reports Server (NTRS)

2000-01-01

Astronaut David Brown poses with members of the team known as ComBBat, representing Central Florida's Astronaut and Titusville high schools. ComBBat was teamed with Boeing at KSC and Brevard Community College. Students from all over the country are at the KSC Visitor Complex for the FIRST (For Inspiration and Recognition of Science and Technology) Southeast Regional competition being held March 9-11 in the Rocket Garden. Teams of high school students are testing the limits of their imagination using robots they have designed, with the support of business and engineering professionals and corporate sponsors, to compete in a technological battle against other schools' robots. Of the 30 high school teams competing, 16 are Florida teams co-sponsored by NASA and KSC contractors. Local high schools participating are Astronaut, Bayside, Cocoa Beach, Eau Gallie, Melbourne, Melbourne Central Catholic, Palm Bay, Rockledge, Satellite, and Titusville.

David Norris with Ford Focus electric cars

NASA Image and Video Library

2017-09-29

David Norris, Marshall transportation specialist, stands alongside two new, fully electric cars capable of traveling approximately 115 miles on a 5 1/2-hour charge using Marshall's 240-volt charging station. The electric cars join five "green" vehicles in use at Marshall since spring 2016.

47 CFR 9.5 - E911 Service.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 1 2014-10-01 2014-10-01 false E911 Service. 9.5 Section 9.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INTERCONNECTED VOICE OVER INTERNET PROTOCOL SERVICES § 9.5 E911 Service. (a) Scope of Section. The following requirements are only applicable to providers of...

47 CFR 9.5 - E911 Service.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 1 2013-10-01 2013-10-01 false E911 Service. 9.5 Section 9.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INTERCONNECTED VOICE OVER INTERNET PROTOCOL SERVICES § 9.5 E911 Service. (a) Scope of Section. The following requirements are only applicable to providers of...

47 CFR 9.5 - E911 Service.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 1 2012-10-01 2012-10-01 false E911 Service. 9.5 Section 9.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INTERCONNECTED VOICE OVER INTERNET PROTOCOL SERVICES § 9.5 E911 Service. (a) Scope of Section. The following requirements are only applicable to providers of...

Recovery- Apollo 9

NASA Image and Video Library

1969-03-13

S69-27467 (13 March 1969) --- The Apollo 9 spacecraft, with astronauts James A. McDivitt, David R. Scott, and Russell L. Schweickart aboard, approaches touchdown in the Atlantic recovery area. Splashdown occurred at 12:00:53 p.m. (EST), March 13, 1969, only 4.5 nautical miles from the prime recovery ship, USS Guadalcanal. Photo credit: NASA

Portrait - Apollo 9 - Prime Crew

NASA Image and Video Library

1966-03-01

S66-30237 (March 1966) --- These three astronauts have been named as the prime crew of the Apollo 9 mission. They are (left to right) David R. Scott, command module pilot; James A. McDivitt, commander; and Russell L. Schweickart, lunar module pilot.

Family Matters: A Conversation with David Popenoe

ERIC Educational Resources Information Center

Iannone, Carol

2009-01-01

This article presents an interview with Professor David Popenoe, author of the controversial book "Disturbing the Nest: Family Change and Decline in Modern Societies" (1988). Popenoe heads the National Marriage Project at Rutgers University, where he taught sociology for forty-five years until his recent retirement. Here, Popenoe discusses his…

Memories of David Kirzhnits

NASA Astrophysics Data System (ADS)

Bolotovsky, B. M.

2013-06-01

In the mid-1950s, a new staff member appeared at the Theory Division of the Physical Institute of the Academy of Sciences (FIAN): David Abramovich Kirzhnits. A Moscow State University alumnus, after graduation he had been assigned to a large defense plant in the city of Gorky, where he had worked for several years as an engineer. He was "liberated" from there by Igor Evgenyevich Tamm, our department head, who managed to transfer him to FIAN. Igor Evgenyevich knew D. A. Kirzhnits - they had met in Moscow before Kirzhnits finished university. At that time Kirzhnits was performing thesis work with professor A. S. Kompaneyets as academic adviser. At his adviser's suggestion, D. Kirzhnits consulted with I. E. Tamm on questions pertaining to the thesis topic. I. E. Tamm took a great liking for the diploma student, and he even wanted to recruit D. A. Kirzhnits for the Theory Division immediately after graduation. But at that time (1949) this proved impossible for several reasons. First, D. Kirzhnits was, as they say, an "invalid of the fifth group" - a Jew - which during those years of violent struggle against cosmopolitanismb often proved an obstacle in looking for work. Second, during the years of mass repressions D. Kirzhnits' father had been arrested on treason charges (according to the charges, he had wanted to sell the Far East to Japan). After intensive investigation his father was released, but he lived only a little longer. Reports of this also could have impeded his acceptance. Third, Igor Evgenyevich didn't have enough weight in officials' eyes at that time and so was unable to overcome "first" and "second."...

David R. Wones 1932-1984

NASA Astrophysics Data System (ADS)

Gilbert, Charles

On Thursday afternoon, October 25, 1984, Dr. David R. Wones, age 52, Professor at Virginia Polytechnic Institute and State University, Fellow of the American Geophysical Union and Secretary of the Volcanology, Geochemistry, and Petrology section 1961-1964, died in an automobile accident in Roanoke, Va. The ultimate cause of this accident is unknown.Dave gave of himself to mineralogy and petrology—in fact, to all of geology and to many colleagues—in a way few can match but that many have experienced and can appreciate.

Reading Pictures: An Interview with David Wiesner

ERIC Educational Resources Information Center

Varga-Dobai, Kinga

2008-01-01

Two-time Caldecott Honor winner (Free Fall, Sector 7) and three-time Caldecott Medal winner (Tuesday, The Three Pigs, Flotsam), David Wiesner is regarded as one of the most remarkable creators of visual storytelling living today. Wiesner is well known for his innovative and unique subject matter and his sophisticated painting-like illustrations…

LAUNCH - APOLLO 9 - CAPE

NASA Image and Video Library

1969-03-03

S69-25861 (3 March 1969) --- The Apollo 9 (Spacecraft 104/Lunar Module 3/ Saturn 504) space vehicle is launched from Pad A, Launch Complex 39, Kennedy Space Center (KSC) at 11 a.m. (EST), March 3, 1969. Aboard the spacecraft are astronauts James A. McDivitt, commander; David R. Scott, command module pilot; and Russell L. Schweickart, lunar module pilot. The Apollo 9 mission will evaluate spacecraft lunar module systems performance during manned Earth-orbital flight. Apollo 9 is the second manned Saturn V mission.

President Carter and the Role of Intelligence in the Camp David Accords

DTIC Science & Technology

2013-11-13

Leadership profiles from the Directorate of Intelligence on the key personalities of the Camp David summit. • Intelligence on informal and form al...PROFILES IN SUPPORT OF THE CAMP DAVID SUMMIT Jerrold Post, M.D. TIMELINE SADAT & BEGIN LEADERSHIP PROFILES BIBLIOGRAPHY SPEAKER BIOGRAPHIES 4 7 15 20...Palestinian state in favor of a moderate Palestinian leadership with which he could negotiate. Nor was Begin’s position on the Palestine issue a

The feckless later reign of King David: a case of major depressive disorder?

PubMed

Ruthven, P; Ruthven, J

2001-01-01

Offers a psychodiagnostic interpretation of King David's later Jerusalem reign which indicates criteria exceedingly those required for a Major Depressive Disorder as listed in the DSM-IV. Opines that whatever other political, polemical, or sociological constructs may be applied to these biblical passages, this interpretative axis supports a scientifically credible account of Yahweh's covenant faithfulness despite David's incapacitating depression.

Nash Receives 2004 David Perlman Award for Excellence in Science Writing

NASA Astrophysics Data System (ADS)

Elmer-DeWitt, Philip; Nash, J. Madeleine

2004-07-01

J. Madeleine Nash received the David Perlman Award for Excellence in Science Writing at the AGU Joint Assembly Honors Ceremony, which was held on 19 May 2004, in Montreal, Canada. Nash was honored for ``Fireproofing the Forests,'' an article that appeared in the 18 August 2003 edition of Time Magazine. ``It is an honor to present AGU's 2004 David Perlman Award to Madeleine Nash, a senior contributor to Time Magazine and, if I may say so, one of the great science writers of her generation.''

A Case of You: Remembering David Fowler

ERIC Educational Resources Information Center

Pimm, David

2004-01-01

The author has framed this brief appreciation of David Flower in terms of influence; specifically, his influence as a teacher, both in person and through his writing (most of all his attempted rewriting of much of the history of Greek mathematics). The author will also make some second-order remarks about the influence of teachers.

Bringing the Social Sciences to Health Policy: An Appreciation of David Mechanic.

PubMed

Boyer, Carol A; Gray, Bradford H

2016-08-01

David Mechanic has been a pioneering leader in the social and behavioral sciences of health, health services, and health and mental health policy for more than fifty years. One of David's most distinctive qualities has been his vision in identifying trends and defining new research areas and perspectives in health care policy. His early work on how methods of physician payment by capitation and fee-for-service in England and the United States affected physicians' responses to patients and patient care addressed present challenges and many ongoing studies of payment mechanisms. His papers on rationing of health care established a framework for examining alternative allocation mechanisms and just decision making. Influential papers dealt with risk selection, policy challenges in managed care, reducing racial disparities, trust relationships between patients, doctors, and the public and health institutions, and the predicaments of health reform. Focusing on the implementation of the Affordable Care Act, David explored its opportunities and challenges especially in providing comprehensive and effective behavioral health services. A hallmark of his work has been his redirecting our attention to the most severely ill and those in greatest need. Less visible is the leadership and institution building endeavors and the many honors David has received. Copyright © 2016 by Duke University Press.

Evidence of effects of human disturbance on alert response in Père David's deer (Elaphurus davidianus).

PubMed

Li, Chunwang; Jiang, Zhigang; Tang, Songhua; Zeng, Yan

2007-11-01

To understand effects of human disturbance on alert response of Père David's deer, we carried out an experiment in the Dafeng Père David's Deer Reserve (32 degrees 59'-33 degrees 03'N, 120 degrees 47'-120 degrees 53'E), China. In the spring and summer, we observed alert responses (including stare, walking away, and flee) of deer and recorded the intensity of tourist disturbance in a small display pen using a laser-range finder to measure the alert distance of a free-ranging group in a large enclosure. We also recorded the pattern of head orientation when deer were resting in these two deer groups. After statistical analysis, we found that: 1) in small pen, the frequency of alert response was significantly different among different intensities of human disturbance; strong disturbance resulted in higher frequency of alert response; 2) stare distance in the free-ranging group in summer was significantly longer than that in spring, but the distance of walking away and the distance of flee showed no significant difference between the two seasons; and 3) in free-ranging group, there was no significant directional difference in head orientation, whereas in display group, there was a significant directional difference in head orientation. We suggest that: 1) under the captive situation, human disturbance may be one of the factors that affect alert response in Père David's deer; and 2) Père David's deer adopted different alert response to adapt to human disturbance under different circumstance. We recommended that relationships between alert response and human disturbance should be considered in ex situ conservation of this field extinct deer. Zoo Biol 26:461-470, 2007. (c) 2007 Wiley-Liss, Inc.

A Cabinet of Mathematical Curiosities at Teachers College: David Eugene Smith's Collection

ERIC Educational Resources Information Center

Murray, Diane R.

2012-01-01

This dissertation is a history of David Eugene Smith's collection of historical books, manuscripts, portraits, and instruments related to mathematics. The study analyzes surviving documents, images, objects, college announcements and catalogs, and secondary sources related to Smith's collection. David Eugene Smith (1860-1944) travelled…

LAUNCH - APOLLO 9 - CAPE

NASA Image and Video Library

1969-03-03

S69-25862 (3 March 1969) --- Framed by palm trees in the foreground, the Apollo 9 (Spacecraft 104/Lunar Module 3/ Saturn 504) space vehicle is launched from Pad A, Launch Complex 39, Kennedy Space Center (KSC) at 11 a.m. (EST), March 3, 1969. Aboard the spacecraft are astronauts James A. McDivitt, commander; David R. Scott, command module pilot; and Russell L. Schweickart, lunar module pilot. The Apollo 9 mission will evaluate spacecraft lunar module systems performance during manned Earth-orbital flight. Apollo 9 is the second manned Saturn V mission.

Apollo 9 Mission image - Scott in CM cabin

NASA Image and Video Library

1969-03-03

View of Astronaut David R.Scott ,Apollo 9 Command Module pilot, inside the Command Module "Gumdrop" during the Apollo 9 earth-orbital mission. . Film magazine was D,film type was SO-368 Ektachrome with 0.460 - 0.710 micrometers film / filter transmittance response and haze filter,80mm lens.

Report from the David Peikoff Chair of Deafness Studies: January 1989 through August 1991.

ERIC Educational Resources Information Center

Schein, Jerome D.

1991-01-01

Following a brief biography of David Peikoff, this paper describes the first occupant of the David Peikoff Chair of Deafness Studies, Jerome D. Schein. The chair's research agenda on mediated communication and demography of impaired hearing are described, as well as organization of an international conference, public addresses, and technical…

Portrait - Apollo 9 Prime Crew

NASA Image and Video Library

1968-12-18

S69-17590 (18 Dec. 1968) --- These three astronauts are the prime crew of the Apollo 9 (Spacecraft 104/ Lunar Module 3/ Saturn 504) space mission. Left to right, are James A. McDivitt, commander; David R. Scott, command module pilot; and Russell L. Schweickart, lunar module pilot.

Astronaut David Brown talks with team members from South Carolina

NASA Technical Reports Server (NTRS)

2000-01-01

Astronaut David Brown looks over the robot named 'L'il Max' with members of the team The Bot Kickers! from Northwestern High School, Rock Hill, S.C. Students from all over the country are at the KSC Visitor Complex for the FIRST (For Inspiration and Recognition of Science and Technology) Southeast Regional competition being held March 9-11 in the Rocket Garden. Teams of high school students are testing the limits of their imagination using robots they have designed, with the support of business and engineering professionals and corporate sponsors, to compete in a technological battle against other schools' robots. Of the 30 high school teams competing, 16 are Florida teams co- sponsored by NASA and KSC contractors. Local high schools participating are Astronaut, Bayside, Cocoa Beach, Eau Gallie, Melbourne, Melbourne Central Catholic, Palm Bay, Rockledge, Satellite, and Titusville.

Battling Creaticide: An Interview with David C. Berliner

ERIC Educational Resources Information Center

Ambrose, Don

2012-01-01

This article presents an interview with David C. Berliner, a Regents' Professor in the College of Education at Arizona State University. His books include "Educational Psychology," "The Manufactured Crisis," and "The Handbook of Educational Psychology." He has served as president of the American Educational Research Association and of the…

Astronaut David Scott practicing for Gemini 8 EVA

NASA Image and Video Library

1966-02-01

S66-19284 (1 Feb. 1966) --- Astronaut David R. Scott practicing for Gemini-8 extravehicular activity (EVA) in building 4 of the Manned Spacecraft Center on the air bearing floor. He is wearing the Hand-Held Maneuvering Unit which he will use during the EVA. Photo credit: NASA

David Haussler, Ph.D., Lectures on Cancer Genomics - TCGA

Cancer.gov

In this lecture, Dr. David Haussler provides a historical overview of the field of genomics leading up to TCGA, including the Cancer Genomics Hub at the University of California, Santa Cruz, and the TCGA Pan-Cancer initiative.

Radar detection of pedestrian-induced vibrations on Michelangelo's David.

PubMed

Pieraccini, Massimiliano; Betti, Michele; Forcellini, Davide; Dei, Devis; Papi, Federico; Bartoli, Gianni; Facchini, Luca; Corazzi, Riccardo; Kovacevic, Vladimir Cerisano

2017-01-01

This paper summarizes the results of a two-day dynamic monitoring of Michelangelo's David subject to environmental loads (city traffic and pedestrian loading induced by tourists visiting the Accademia Gallery). The monitoring was carried out by a no-contact technique using an interferometric radar, whose effectiveness in measuring the resonant frequencies of structures and historic monuments has proved over the last years through numerous monitoring activities. Owing to the dynamic behavior of the measurement system (radar and tripod), an accelerometer has been installed on the radar head to filter out the movement component of the measuring instrument from the measurement of the David's displacement. Measurements were carried out in the presence and absence of visitors, to assess their influence on the dynamic behavior of the statue. A numerical model of the statue was employed to evaluate the experimental results.

Radar detection of pedestrian-induced vibrations on Michelangelo's David

PubMed Central

2017-01-01

This paper summarizes the results of a two-day dynamic monitoring of Michelangelo's David subject to environmental loads (city traffic and pedestrian loading induced by tourists visiting the Accademia Gallery). The monitoring was carried out by a no-contact technique using an interferometric radar, whose effectiveness in measuring the resonant frequencies of structures and historic monuments has proved over the last years through numerous monitoring activities. Owing to the dynamic behavior of the measurement system (radar and tripod), an accelerometer has been installed on the radar head to filter out the movement component of the measuring instrument from the measurement of the David's displacement. Measurements were carried out in the presence and absence of visitors, to assess their influence on the dynamic behavior of the statue. A numerical model of the statue was employed to evaluate the experimental results. PMID:28394932

Grade 1 Students Meet David Wiesner's "Three Pigs."

ERIC Educational Resources Information Center

Pantaleo, Sylvia

2002-01-01

Describes the oral, written, and visual arts responses of a group of Grade 1 children. Discusses first grade children's understandings of and responses to several Radical Change characteristics and metafictive techniques found in David Wiesner's "The Three Pigs" (2001), the 2002 Randolph Caldecott Medal winner. Explores the nature of the…

Crew Training - Apollo 9 - KSC

NASA Image and Video Library

1969-02-17

S69-19983 (17 Feb. 1969) --- The Apollo 9 crew is shown suited up for a simulated flight in the Apollo Mission Simulator at the Kennedy Space Center (KSC). Left to right are astronauts James A. McDivitt, commander; David R. Scott, command module pilot; and Russell L. Schweickart, lunar module pilot.

Interview With the 2002 Caldecott Medal Winner, David Wiesner.

ERIC Educational Resources Information Center

Giorgis, Cyndi; Johnson, Nancy J.

2003-01-01

Discusses David Wiesner, the 2002 Caldecott Medal Winner, and includes excerpts of an interview with him. Notes that Wiesner's books appeal to the imagination and often use art elements such as scale. Details the winning book, "The Three Pigs." (PM)

David Almond's "Skellig": "A New Vista of Contemplation"?

ERIC Educational Resources Information Center

Stewart, Susan Louise

2009-01-01

The debates that have arisen regarding Darwin's theories of evolution and Christian views of creation and their place in education in the United States have frequently been extremely heated, resulting in trials, hearings, and laws. This article provides an overview of some of the disagreements and illustrates how David Almond's British novel,…

Crew Training - Apollo 9 (Alt. Chamber) - KSC

NASA Image and Video Library

1968-01-01

S68-55272 (15 Nov. 1968) --- The Apollo 9 prime crew is seen inside the Apollo 9 spacecraft in the Kennedy Space Center's Manned Spacecraft Operations Building during manned altitude chamber test activity. Left to right, are astronauts James A. McDivitt, commander; David R. Scott, command module pilot; and Russell L. Schweickart (out of view to far right), lunar module pilot.

Sinkhole-type subsidence over abandoned coal mines in St. David, Illinois. Mine subsidence report, St. David, Illinois. A field survey and analysis of mine subsidence of abandoned coal mines in St. David, Illinois

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wildanger, E.G.; Mahar, J.; Nieto, A.

1980-01-01

This study examined the geologic data, mining history, and subsidence trends of the St. David region. Mine subsidence has occurred due to collapse of the abandoned mine workings. The known subsidence areas have been mapped and described. Results of the study include: (1) St. David has been undermined by both large shipping mines and smaller local mines; (2) sinkholes will continue to develop in this area in response to rock failure and roof collapse above the abandoned mine workings; (3) some primary factors that contribute to the sinkhole problems are the undermining and roof rock composition; (4) sinkholes will bemore » smaller in the future; (5) ten of the 63 sinkholes occurred close enough to structures to cause damage, and only six sinkholes caused damage; (6) ways to minimize potential damage to future homes from sinkhole subsidence are manageable; (7) threats to residents lie in the collapse of heavy walls, brick chimneys, breaks in gas, water, or electrical lines; and (8) location of future subsidence is not predictable. (DP)« less

Astronaut David Brown talks with team members from Lake Buena Vista, Fla

NASA Technical Reports Server (NTRS)

2000-01-01

Astronaut David Brown chats with members of the Explorers team, from Lake Buena Vista, Fla., during the FIRST (For Inspiration and Recognition of Science and Technology) Southeast Regional competition held March 9-11 in the KSC Visitor Complex Rocket Garden. Teams of high school students from all over the country are testing the limits of their imagination using robots they have designed, with the support of business and engineering professionals and corporate sponsors, to compete in a technological battle against other schools' robots. Of the 30 high school teams competing at the Southeast Regional event, 16 are Florida teams co-sponsored by NASA and KSC contractors. Local high schools participating are Astronaut, Bayside, Cocoa Beach, Eau Gallie, Melbourne, Melbourne Central Catholic, Palm Bay, Rockledge, Satellite, and Titusville.

INFLIGHT - APOLLO 9 (CREW ACTIVITIES)

NASA Image and Video Library

1968-03-07

S69-26698 (March 1969) --- A photograph from a live television transmission from Apollo 9. This view shows the interior of the Lunar Module "Spider." Astronaut James A. McDivitt, Apollo 9 commander, is in right foreground. In left background is astronaut Russell L. Schweickart, lunar module pilot. At this moment Apollo 9 was orbiting Earth with the Command Module docked nose-to-nose with the Lunar Module. Astronaut David R. Scott, command module pilot, remained at the controls in the Command Module "Gumdrop" while the other two astronauts checked out the Lunar Module.

David Hubel and Torsten Wiesel.

PubMed

Hubel, David; Wiesel, Torsten

2012-07-26

While attending medical school at McGill, David Hubel developed an interest in the nervous system during the summers he spent at the Montreal Neurological Institute. After heading to the United States in 1954 for a Neurology year at Johns Hopkins, he was drafted by the army and was assigned to the Neuropsychiatry Division at the Walter Reed Hospital, where he began his career in research and did his first recordings from the visual cortex of sleeping and awake cats. In 1958, he moved to the lab of Stephen Kuffler at Johns Hopkins, where he began a long and fruitful collaboration with Torsten Wiesel. Born in Sweden, Torsten Wiesel began his scientific career at the Karolinska Institute, where he received his medical degree in 1954. After spending a year in Carl Gustaf Bernhard's laboratory doing basic neurophysiological research, he moved to the United States to be a postdoctoral fellow with Stephen Kuffler. It was at Johns Hopkins where he met David Hubel in 1958, and they began working together on exploring the receptive field properties of neurons in the visual cortex. Their collaboration continued until the late seventies. Hubel and Wiesel's work provided fundamental insight into information processing in the visual system and laid the foundation for the field of visual neuroscience. They have had many achievements, including--but not limited to--the discovery of orientation selectivity in visual cortex neurons and the characterization of the columnar organization of visual cortex through their discovery of orientation columns and ocular-dominance columns. Their work earned them the Nobel Prize for Physiology or Medicine in 1981, which they shared with Roger Sperry. Copyright © 2012 Elsevier Inc. All rights reserved.

David L. Rosenhan (1929-2012).

PubMed

Ross, Lee; Kavanagh, David

2013-09-01

Presents an obituary for David L. Rosenhan (1929-2012). A distinguished psychologist and professor emeritus at Stanford University, Rosenhan died February 6, 2012, at the age of 82, after a long illness. Born in Jersey City, New Jersey, on November 22, 1929, he received a bachelor's degree in mathematics (1951) from Yeshiva College and a master's degree in economics (1953) and a doctorate in psychology (1958) from Columbia University. A professor of law and of psychology at Stanford University from 1971 until his retirement in 1998, Rosenhan was a pioneer in applying psychological methods to the practice of law, including the examination of expert witnesses, jury selection, and jury deliberation. A former president of the American Psychology-Law Society and of the American Board of Forensic Psychology, Rosenhan was a fellow of the American Association for the Advancement of Science, of the American Psychological Association, and of the American Psychological Society. Before joining the Stanford Law School faculty, he was a member of the faculties of Swarthmore College, Princeton University, Haverford College, and the University of Pennsylvania. He also served as a research psychologist at the Educational Testing Service. As generations of Stanford students can attest, David Rosenhan was a spellbinding lecturer who managed to convey the sense that he was speaking to each individual, no matter how large the group. To his graduate students, he was consistently encouraging and optimistic, always ready to share a joke or story, and gently encouraging of their creativity and progressive independence as researchers. The lessons he cared most about offering, in the classroom as in his research, were about human dignity and the need to confront abuse of power and human frailties. © 2013 APA, all rights reserved.

77 FR 26765 - David H.M. Phelps: Debarment Order

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-07

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-N-0879] David H.M. Phelps: Debarment Order AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The U.S. Food and Drug Administration (FDA) is issuing an order under the Federal Food, Drug, and...

8. Historic American Buildings Survey, David Aronow, Photographer circa 1924, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Historic American Buildings Survey, David Aronow, Photographer circa 1924, LIVING ROOM WITH TIFFANY STAINED GLASS WINDOWS INCLUDING 'FEEDING THE FLAMINGOES,' 'THE FOUR SEASONS,' AND 'THE BATHERS'. - Laurelton Hall, Laurel Hollow & Ridge Roads, Oyster Bay, Nassau County, NY

Astronaut David Scott - Sample - "Genesis Rock" - MSC

NASA Image and Video Library

1971-08-12

S71-43477 (12 Aug. 1971) --- Astronaut David R. Scott, right, commander of the Apollo 15 mission, gets a close look at the sample referred to as "Genesis rock" in the Non-Sterile Nitrogen Processing Line (NNPL) in the Lunar Receiving Laboratory (LRL) at the Manned Spacecraft Center (MSC). Scientist-astronaut Joseph P. Allen IV, left, an Apollo 15 spacecraft communicator, looks on with interest. The white-colored rock has been given the permanent identification of 15415.

Instructional Implications of David C. Geary's Evolutionary Educational Psychology

ERIC Educational Resources Information Center

Sweller, John

2008-01-01

David C. Geary's thesis has the potential to alter our understanding of those aspects of human cognition relevant to instruction. His distinction between biologically primary knowledge that we have evolved to acquire and biologically secondary knowledge that is culturally important, taught in educational institutions and which we have not evolved…

Materials characterization activities for %E2%80%9CTake Our Sons&Daughters to Work Day%E2%80%9D 2013.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mowry, Curtis Dale; Pimentel, Adam S.; Sparks, Elizabeth Schares

We created interactive demonstration activities for Take Our Daughters&Sons to Work Day (TODSTWD) 2013 in order to promote general interest in chemistry and also generate awareness of the type of work our laboratories can perform. %E2%80%9CCurious about Mars Rover Curiosity?%E2%80%9D performed an elemental analysis on rocks brought to our lab using the same technique utilized on the planet Mars by the NASA robotic explorer Curiosity. %E2%80%9CFood is Chemistry?%E2%80%9D utilized a mass spectrometer to measure, in seconds, each participant's breath in order to identify the food item consumed for the activity. A total of over 130 children participated in these activitiesmore » over a 3 hour block, and feedback was positive. This document reports the materials (including handouts), experimental procedures, and lessons learned so that future demonstrations can benefit from the baseline work performed. We also present example results used to prepare the Food activity and example results collected during the Curiosity demo.« less

Recovery - Apollo 9

NASA Image and Video Library

1969-03-13

S69-27746 (13 March 1969) --- The Apollo 9 crew awaits the arrival of a recovery helicopter from the USS Guadalcanal, prime recovery ship for the Apollo 9 10-day Earth-orbital space mission. Astronaut James A. McDivitt, commander, stands in hatch of spacecraft. Already in life raft are astronauts Russell L. Schweickart (foreground), lunar module pilot, and David R. Scott, command module pilot. Scott is taking a picture of McDivitt. Splashdown occurred at 12:00:53 p.m. (EST), March 13, 1969, only 4.5 nautical miles from the USS Guadalcanal. U.S. Navy underwater demolition team swimmers assist in the recovery operations.

STS-69 Mission Commander David M. Walker in white room

NASA Technical Reports Server (NTRS)

1995-01-01

STS-69 Mission Commander David M. Walker chats with white room closeout crew members Bob Saulnier (left), Regulo Villalobos and closeout crew leader Travis Thompson prior to entering the flight deck of the Space Shuttle Endeavour at Launch Pad 39A.

Video from Panel Discussion with Joseph Fraumeni and David Schottenfeld

Cancer.gov

Video footage from Panel Discussion with Joseph Fraumeni and David Schottenfeld on Cancer Epidemiology over the Last Half-Century and Thoughts on the Future. The discussion took place on May 11, 2012, when DCEG hosted Dr. Schottenfeld as a Visiting Scholar.

Astronaut David Wolf in medical experiment in SLS-2

NASA Technical Reports Server (NTRS)

1993-01-01

Astronaut David A. Wolf, mission specialist, participates in an experiment that investigates in-space distribution and movement of blood and gas in the pulmonary system. The data gathered during the two-week flight will be compared with results of tests performed on Earth to determine the changes that occur in pulmonary functions.

9. Detail Showing top of Samson Post and Walking Beam ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Detail Showing top of Samson Post and Walking Beam Pivot, Looking East - David Renfrew Oil Rig, East side of Connoquenessing Creek, 0.4 mile North of confluence with Thorn Creek, Renfrew, Butler County, PA

David Mechanic: Professional Zombie Hunter.

PubMed

Hafferty, Frederic W; Tilburt, Jon

2016-08-01

Within the fields of medicine and sociology, the descriptor "profession" (along with its brethren: profession, professionalization, and professionalism) has had a rich etymological history, with terms taking on different meanings at different times-sometimes trespassing into shibboleth and jargon. This etymological journey has co-evolved with the career of David Mechanic to whom this issue of the Journal of Health Politics, Policy and Law is devoted. We exploit a provocative metaphor applied to Mechanic's work on the challenges facing medicine as a profession as a playful exegesis on what we call "profession" to excavate an ensconced and encrusted domain of health jargon operating at the tensive interface of society and modern medical work. Copyright © 2016 by Duke University Press.

Challenging Texts: Teaching Deliberately--Reading Henry David Thoreau's "Walden"

ERIC Educational Resources Information Center

Davis, Andrea

2011-01-01

One of the more difficult 19th-century American texts for high school students to read is undoubtedly Henry David Thoreau's "Walden." His erudite allusions, often page-long sentences, and sophisticated sense of the ironic initially leave many students cold. Still, the author encourages them to read amid the din of a cultural cacophony that shouts…

Can Cosmopolitanism Work Religiously? A Response to David T. Hansen

ERIC Educational Resources Information Center

Ghiloni, Aaron J.

2017-01-01

This response to David T. Hansen's 2016 plenary address to the Religious Education Association tests the viability of educational cosmopolitanism for religious education. Using a Deweyan methodology of understanding an idea through its consequences, Hansen's proposal is analyzed using dialogues with interreligious and Islamic pedagogies. The…

Repeating ice-earthquakes beneath David Glacier from the 2012-2015 TAMNNET array

NASA Astrophysics Data System (ADS)

Walter, J. I.; Peng, Z.; Hansen, S. E.

2017-12-01

The continent of Antarctica has approximately the same surface area as the continental United States, though we know significantly less about its underlying geology and seismic activity. In recent years, improvements in seismic instrumentation, battery technology, and field deployment practices have allowed for continuous broadband stations throughout the dark Antarctic winter. We utilize broadband seismic data from a recent experiment (TAMNNET), which was originally proposed as a structural seismology experiment, for seismic event detection. Our target is to address fundamental questions about regional-scale crustal and environmental seismicity in the study region that comprises the Transantarctic Mountain area of Victoria and Oates Land. We identify most seismicity emanating from David Glacier, upstream of the Drygalski Ice Tongue, which has been documented by several other studies. In order to improve the catalog completeness for the David Glacier area, we utilize a matched-filter technique to identify potential missing earthquakes that may not have been originally detected. This technique utilizes existing cataloged waveforms as templates to scan through continuous data and to identify repeating or nearby earthquakes. With a more robust catalog, we evaluate relative changes in icequake positions, recurrence intervals, and other first-order information. In addition, we attempt to further refine locations of other regional seismicity using a variety of methods including body and surface wave polarization, beamforming, surface wave dispersion, and other seismological methods. This project highlights the usefulness of archiving raw datasets (i.e., passive seismic continuous data), so that researchers may apply new algorithms or techniques to test hypotheses not originally or specifically targeted by the original experimental design.

America's foremost early astronomer. [David Rittenhouse

NASA Technical Reports Server (NTRS)

Rubincam, David Parry; Rubincam, Milton, II

1995-01-01

The life of 18th century astronomer, craftsman, and partriot David Rittenhouse is detailed. As a craftsman, he distinguished himself as one of the foremost builders of clocks. He also built magnetic compasses and surveying instruments. The finest examples of his craftsmanship are considered two orreries, mechanical solar systems. In terms of astronomical observations, his best-known contribution was his observation of the transit of Venus in 1769. Rittenhouse constructed the first diffraction grating. Working as Treasurer of Pennsylvania throughout the Revolution, he became the first director of the Mint in 1792. Astronomical observations in later life included charting the position of Uranus after its discovery.

Spent nuclear fuel canister storage building conceptual design report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swenson, C.E.

This Conceptual Design Report provides the technical basis for the Spent Nuclear Fuels Project, Canister Storage Building, and as amended by letter (correspondence number 9555700, M.E. Witherspoon to E.B. Sellers, ``Technical Baseline and Updated Cost Estimate for the Canister Storage Building``, dated October 24, 1995), includes the project cost baseline and Criteria to be used as the basis for starting detailed design in fiscal year 1995.

Can Education Save the World? A Response to David Gruenewald

ERIC Educational Resources Information Center

Stables, Andrew

2004-01-01

Any commitment to education for sustainability assumes that teaching and learning can reduce or prevent damage to the biosphere. However, such an assumption remains deeply problematic. David Gruenewald's is only one of several possible epistemological positions. This article discusses the variety of such positions, arguing for that which might…

David Dorfman's "Here": A Community-Building Approach in Dance Education

ERIC Educational Resources Information Center

Parrish, Mila

2009-01-01

Over a three-month period, Arcadia High School and Arizona State University formed a community partnership with the help of New York modern dance choreographer David Dorfman to create an original dance titled "Here." Dorfman's community-building approach is based on personal refection, collaboration, critical thinking, problem solving,…

Recovery- Apollo 9

NASA Image and Video Library

1969-03-13

S69-27920 (13 March 1969) --- The Apollo 9 crew men walk on a red carpet after arriving aboard the prime recovery ship, USS Guadalcanal. Left to right, are astronauts Russell L. Schweickart, David R. Scott, and James A. McDivitt. They are walking from the recovery helicopter which picked them up from the splashdown area. Splashdown occurred at 12:00:53 p.m. (EST), March 13, 1969, only 4.5 nautical miles from the USS Guadalcanal to conclude a successful 10-day Earth-orbital space mission.

Attitudes of Mississippi college students toward David Duke before and after seeing the film Who is David Duke?

PubMed

Eisenman, R; Girdner, E J; Burroughs, R G; Routman, M

1993-01-01

The attitudes of 211 students at a university in Mississippi were investigated both before and after seeing the Public Broadcasting Film Who Is David Duke? The film provided evidence of Duke's current racism, anti-Semitism, and pro-Nazi leanings. In a previous study with university students in Louisiana, the majority did not change their attitudes after watching the film (Eisenman, 1993). However, in the present study, students' attitudes showed change in an anti-Duke direction. The findings are discussed and reasons given for the differences between the two samples, and for the popularity of Duke, a former leader of the Ku Klux Klan.

Interview with David H. Jonassen: Looking at the Field of Educational Technology from Radical and Multiple Perspectives

ERIC Educational Resources Information Center

Simsek, Ali

2012-01-01

There are people whose names are identified with their fields. When an outsider wants to learn about the field of educational technology and enters some keywords, David H. Jonassen is perhaps one the few people whose names will appear instantly. Of course, this is not without reasons. David H. Jonassen has produced enormous amount of work…

Launch - Apollo 9 - KSC

NASA Image and Video Library

1969-03-03

S69-25881 (3 March 1969) --- The Apollo 9 crew leaves the Kennedy Space Center's Manned Spacecraft Operations Building during the Apollo 9 prelaunch countdown. The crewman entered the special transfer van which transported them to their waiting spacecraft at Pad A, Launch Complex 39. Astronaut James A. McDivitt (back to camera) is the commander. McDivitt appears to be inviting astronaut David R. Scott, command module pilot, to step first into van. In background is astronaut Russell L. Schweickart, lunar module pilot. Walking along almost behind Schweickart is astronaut Alan B. Shepard Jr., chief, Astronaut Office, Manned Spacecraft Center. Apollo 9 was launched at 11 a.m. (EST), March 3, 1969, on a 10-day Earth-orbital mission.

Reflections on the Scholarly Contributions of Professor David H. Jonassen

ERIC Educational Resources Information Center

Reeves, Thomas C.; Lee, Chwee Beng; Hung, Woei

2013-01-01

The six papers in this special issue of "Computers and Education" honoring Professor David H. Jonassen are diverse in nature. They also reflect differing interpretations of the implications of Jonassen's work for research and development focused on instructional models and the factors influencing instruction as well as the directions for future…

The Post-9/11 Veterans Educational Assistance Improvements Act of 2010

DTIC Science & Technology

2010-08-02

Administration ( NOAA ) to transfer Post-9/11 GI Bill benefits to their dependents; • require the Secretaries concerned to reimburse the Department of Veterans...the Marine Gunnery Sergeant John David Fry Scholarship within the Post-9/11 GI Bill. The scholarship program provides some Post-9/11 GI Bill...officers of the Public Health Service (PHS) and National Oceanic and Atmospheric Administration ( NOAA ) to transfer Post-9/11 GI Bill benefits to

The Post-9/11 Veterans Educational Assistance Improvements Act of 2010

DTIC Science & Technology

2010-08-13

NOAA ) to transfer Post-9/11 GI Bill benefits to their dependents; • require the Secretaries concerned to reimburse the Department of Veterans...Marine Gunnery Sergeant John David Fry Scholarship within the Post-9/11 GI Bill. The scholarship program provides some Post-9/11 GI Bill benefits to...Service (PHS) and National Oceanic and Atmospheric Administration ( NOAA ) to transfer Post-9/11 GI Bill benefits to dependents.35 Under current law, the

Learning "from Europe" and "for Europe" with David Raffe--Insights into Early Years of European Cooperation in "Vocational Education and Training Research"

ERIC Educational Resources Information Center

Kämäräinen, Pekka

2017-01-01

This article provides a picture on the contribution of David Raffe to European cooperation in the field of vocational education and training (VET). It is based on the experiences of the author and his colleagues on European events and projects in which David participated from the early 1990s until 2009. The Section 2 gives impressions of David's…

David Lasser: An American Spaceflight Pioneer

NASA Astrophysics Data System (ADS)

Ciancone, Michael L.; Lasser, Amelia

2002-01-01

David Lasser was one of the founders of the American Interplanetary Society (later known as the American Rocket Society) and author of the first English-language book (in 1931) on the prospects of human spaceflight. Yet his involvement in the fledgling spaceflight movement was short-lived as he soon moved on to pursue a distinguished career in the cause of workers rights. In lieu of an oral history, the author corresponded with Mr. Lasser on a regular basis in the years before his death in 1996 to gather Mr. Lasser's views on human spaceflight activities as viewed from his unique perspective. This paper will document that correspondence with one of America's original spaceflight pioneers.

Aortic Root Biomechanics After Sleeve and David Sparing Techniques: A Finite Element Analysis.

PubMed

Tasca, Giordano; Selmi, Matteo; Votta, Emiliano; Redaelli, Paola; Sturla, Francesco; Redaelli, Alberto; Gamba, Amando

2017-05-01

Aortic root aneurysm can be treated with valve-sparing procedures. The David and Yacoub techniques have shown excellent long-term results but are technically demanding. Recently, a new and simpler procedure, the Sleeve technique, was proposed with encouraging results. We aimed to quantify the biomechanics of the initially aneurysmal aortic root (AR) after the Sleeve procedure to assess whether it induces abnormal stresses, potentially undermining its durability. Two finite element (FE) models of the physiologic and aneurysmal AR were built, accounting for the anatomical asymmetry and the nonlinear and anisotropic mechanical properties of human AR tissues. On the aneurysmal model, the Sleeve and David techniques were simulated based on the corresponding published technical features. Aortic root biomechanics throughout 2 consecutive cardiac cycles were computed in each simulated configuration. Both sparing techniques restored physiologic-like kinematics of aortic valve (AV) leaflets but induced different leaflets stresses. The time course averaged over the leaflets' bellies was 35% higher in the David model than in the Sleeve model. Commissural stresses, which were equal to 153 and 318 kPa in the physiologic and aneurysmal models, respectively, became 369 and 208 kPa in the David and Sleeve models, respectively. No intrinsic structural problems were detected in the Sleeve model that might jeopardize the durability of the procedure. If corroborated by long-term clinical outcomes, the results obtained suggest that using this new technique could successfully simplify the surgical repair of AR aneurysms and reduce intraoperative complications. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

STS-69 Mission Commander David M. Walker returns to KSC

NASA Technical Reports Server (NTRS)

1995-01-01

STS-69 Mission Commander David M. Walker and four fellow crew members return to KSC for a second launch try. The Space Shuttle Endeavour is scheduled for liftoff on Sept. 7 at 11:09 a.m. EDT, just about a week after the first try was scrubbed due to a faulty fuel cell.

Empowering Adolescent Readers: Intertextuality in Three Novels by David Almond

ERIC Educational Resources Information Center

Latham, Don

2008-01-01

In "Skellig," "Kit's Wilderness," and "Clay", David Almond employs various types of intertextuality to enrich his narratives. Through the use of allusion, adaptation, collage, and mise-en-abyme, he encourages his adolescent readers to seek out precursor texts and to consider the interrelationships between these texts and his own. By so doing, he…

Child Welfare Research and Training: A Response to David Stoesz

ERIC Educational Resources Information Center

Smith, Brenda D.; Vandiver, Vikki L.

2016-01-01

In this response to David Stoesz' critique, "The Child Welfare Cartel," the authors agree that child welfare research and training must be improved. The authors disagree, however, with Stoesz' critique of social work education, his assessment of the most-needed forms of child welfare research, and his depiction of the goals and…

STS-69 Mission Commander David M. Walker suits up

NASA Technical Reports Server (NTRS)

1995-01-01

STS-69 Mission Commander David M. Walker signals he's ready to fly as he finishes donning his launch/entry suit in the Operations and Checkout Building. Walker, who is embarking on his fourth trip into space, will depart shortly for Launch Pad 39A along with four fellow crew members. Awaiting the crew and liftoff at 11:09 a.m. EDT is the Space Shuttle Endeavour.

Astronaut David Wolf in medical experiment in SLS-2

NASA Image and Video Library

1993-10-28

STS058-204-014 (18 Oct.-1 Nov. 1993) --- Astronaut David A. Wolf, mission specialist, participates in an experiment that investigates in-space distribution and movement of blood and gas in the pulmonary system. The data gathered during the two-week flight will be compared with results of tests performed on Earth to determine the changes that occur in pulmonary functions. Photo credit: NASA

Straight talk with...David Baker.

PubMed

Baker, David; Khamsi, Roxanne

2012-11-01

Thirty years ago, technology companies began nestling their facilities close to academia, and the idea of the university research park was born. Soon after, the concept took off in the field of medicine, and today it's not hard to find such innovation hubs that house biomedical startups drawing on the brainpower of professors and students alike. In late September, the Tucson, Arizona-based Association of University Research Parks--which includes about 170 research parks--announced that David Baker would serve as president of the organization's board of directors for the next year and help guide its strategic goals for the next five years. Baker, who is also the executive director of the University Technology Park at the Illinois Institute of Technology in Chicago, spoke with Roxanne Khamsi about how the organization hopes to branch out and transform these workplaces.

E9-Im9 Colicin DNase−Immunity Protein Biomolecular Association in Water: A Multiple-Copy and Accelerated Molecular Dynamics Simulation Study

PubMed Central

2008-01-01

Protein−protein transient and dynamic interactions underlie all biological processes. The molecular dynamics (MD) of the E9 colicin DNase protein, its Im9 inhibitor protein, and their E9-Im9 recognition complex are investigated by combining multiple-copy (MC) MD and accelerated MD (aMD) explicit-solvent simulation approaches, after validation with crystalline-phase and solution experiments. Im9 shows higher flexibility than its E9 counterpart. Im9 displays a significant reduction of backbone flexibility and a remarkable increase in motional correlation upon E9 association. Im9 loops 23−31 and 54−64 open with respect to the E9-Im9 X-ray structure and show high conformational diversity. Upon association a large fraction (∼20 nm2) of E9 and Im9 protein surfaces become inaccessible to water. Numerous salt bridges transiently occurring throughout our six 50 ns long MC-MD simulations are not present in the X-ray model. Among these Im9 Glu31−E9 Arg96 and Im9 Glu41−Lys89 involve interface interactions. Through the use of 10 ns of Im9 aMD simulation, we reconcile the largest thermodynamic impact measured for Asp51Ala mutation with Im9 structure and dynamics. Lys57 acts as an essential molecular switch to shift Im9 surface loop towards an ideal configuration for E9 inhibition. This is achieved by switching Asp60−Lys57 and Asp62−Lys57 hydrogen bonds to Asp51−Lys57 salt bridge. E9-Im9 recognition involves shifts of conformational distributions, reorganization of intramolecular hydrogen bond patterns, and formation of new inter- and intramolecular interactions. The description of key transient biological interactions can be significantly enriched by the dynamic and atomic-level information provided by computer simulations. PMID:19053689

Moral philosophers are moral experts! A reply to David Archard.

PubMed

Gordon, John-Stewart

2014-05-01

In his article 'Why Moral Philosophers Are Not and Should Not Be Moral Experts' David Archard attempts to show that his argument from common-sense morality is more convincing than other competing arguments in the debate. I examine his main line of argumentation and eventually refute his main argument in my reply. © 2012 John Wiley & Sons Ltd.

Investing in the Child Welfare Workforce: A Response to David Stoesz

ERIC Educational Resources Information Center

Briar-Lawson, Katharine; Leake, Robin; Dickinson, Nancy; McCarthy, Mary; Anderson, Gary; Groza, Victor; Gilmore, Grover C.

2016-01-01

Responding to David Stoesz's invited article criticizing the Children's Bureau and the National Child Welfare Workforce Institute (NCWWI), the author's inaccurate assertions are challenged, and new information is provided about the significant work underway to support the child welfare workforce. The Children's Bureau has made historic investments…

On a Theme by Rene David: Comparative Law as "Technique Indispensable."

ERIC Educational Resources Information Center

McAuley, Michael

2002-01-01

Explores a text by Rene David relating to the teaching of comparative law and the comparative teaching of law. Discusses bijural education as a way to comprehensively teach the civil and common law traditions. Addresses construction of a bijural curriculum and skills of comparative law teaching. (EV)

Using optically scanned 3D data in the restoration of Michelangelo's David

NASA Astrophysics Data System (ADS)

Scopigno, Roberto; Cignoni, Paolo; Callieri, Marco; Ganovelli, Fabio; Impoco, G.; Pingi, P.; Ponchio, F.

2003-10-01

Modern 3D scanning technologies allow to reconstruct 3D digital representations of Cultural Heritage artifacts in a semi-automatic way, characterized by very high accuracy and wealth of details. The availability of an accurate digital representation opens several possibilities of utilization to experts (restorers, archivists, museum curators), or to ordinary people (students, museum visitors). 3D scanned data are commonly used for the production of animations, interactive visualizations, or virtual reality applications. A much more exciting opportunity is to use these data in the restoration of Cultural Heritage artworks. The integration between 3D graphic and restoration represents an open research field where many new supporting tools are required; the David restoration project has given several starting points and guidelines to the definition and development of innovative solutions. Digital 3D models can be used in two different but not subsidiary modes: as an instrument for the execution of specific investigations and as a supporting media for the archival and integration of all the restoration-related information, gathered with the different studies and analysis performed on the artwork. In this paper we present some recent work done in the framework of the Michelangelo's David restoration project. A 3D model of the David was reconstructed by the Digital Michelangelo Project, using laser-based 3D scanning technology. We have developed some tools to make those data accessible and useful in the restoration. Preliminary results are reported here together with some directions for further research.

Q & A with Ed Tech Leaders: Interview with David M. Monetti

ERIC Educational Resources Information Center

Fulgham, Susan M.; Shaughnessy, Michael F.

2014-01-01

Contributing editors Susan Fulgham and Michael Shaughnessy present their interview with David M. Monetti, Professor in the Department of Psychology and Counseling at Valdosta State University. Monetti teaches courses in educational psychology, learning, and measurement and evaluation. He is actively involved with the public schools as a researcher…

Astronaut David Wolf draws blood from Martin Fettman for SLS-2 investigations

NASA Technical Reports Server (NTRS)

1993-01-01

Inside the science module aboard the Earth-orbiting Space Shuttle Columbia, Astronaut David A. Wolf draws blood from payload specialists Martin J. Fettman, DVM. Blood samples from crew members are critical to several Spacelab Life Sciences (SLS-2) investigations.

"Who's Afraid of Secularisation?" A Response to David Lewin

ERIC Educational Resources Information Center

Jackson, Robert

2017-01-01

This response to David Lewin states the purpose of my critique of some aspects of Liam Gearon's work. It clarifies my position on the aims of "inclusive" religious education, rejecting Gearon's view that REDCo researchers shared a common pluralistic theology, regarding religious education as having a single political aim. It reinforces…

Builders Challenge High Performance Builder Spotlight: David Weekley Homes, Houston, Texas

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2009-12-22

Building America Builders Challenge fact sheet on David Weekley Homes of Houston, Texas. The builder plans homes as a "system," with features such as wood-framed walls that are air-sealed then insulated with R-13 unfaced fiberglass batts plus an external covering of R-2 polyisocyanurate rigid foam sheathing.

David F. Treagust: Congenial Soul, Science Educator, and International Research Leader

ERIC Educational Resources Information Center

Tobin, Kenneth; Rennie, Leonie; Venville, Grady; Chu, Hye-Eun; Fensham, Peter; Gallagher, James; Duit, Reinders; Graeber, Wolfgang; van den Berg, Ed; Hand, Brian; Ritchie, Stephen; Dillon, Justin

2011-01-01

For almost a half century David F. Treagust has been an exemplary science educator who has contributed through his dedication and commitments to students, curriculum development and collaboration with teachers, and cutting edge research in science education that has impacted the field globally, nationally and locally. A hallmark of his outstanding…

Apollo 9 Spacecraft - Touchdown - Atlantic Recovery Area

NASA Image and Video Library

1969-03-13

S69-27466 (13 March 1969) --- The Apollo 9 spacecraft, with astronauts James A. McDivitt, David R. Scott, and Russell L. Schweickart aboard, touches down in the Atlantic recovery area to conclude a successful 10-day Earth-orbital space mission. Splashdown occurred at 12:00:53 p.m. (EST), March 13, 1969, only 4.5 nautical miles from the prime recovery ship, USS Guadalcanal.

Apollo 9 crew leaves Spacecraft Operations Building during countdown

NASA Image and Video Library

1969-03-03

S69-25883 (3 March 1969) --- The Apollo 9 crew leaves the Kennedy Space Center's Manned Spacecraft Operations Building during the Apollo 9 prelaunch countdown. Leading is astronaut James A. McDivitt, commander; followed by astronaut David R. Scott, command module pilot; and Russell L. Schweickart, lunar module pilot. Moments later they entered the special transfer van which transported them to their waiting spacecraft at Pad A, Launch Complex 39. Apollo 9 was launched at 11 a.m. (EST), March 3, 1969, on a 10-day Earth-orbital mission.

David Noble's Battle to Defend the 'Sacred Space' of the Classroom.

ERIC Educational Resources Information Center

Young, Jeffrey R.

2000-01-01

Reports on the crusade of David F. Noble, a history professor at York University (Ontario), against distance education, which he sees as the latest episode in the saga of the corporatization of American higher education. Notes Noble's views on the relationship between politics and technology, intellectual property issues of courseware, and the…

Apollo 9 Lunar Module in lunar landing configuration

NASA Image and Video Library

1969-03-07

AS09-21-3181 (7 March 1969) --- A View of the Apollo 9 Lunar Module (LM), "Spider," in a lunar lading configuration, as photographed from the Command and Service Modules (CSM) on the fifth day of the Apollo 9 Earth-orbital mission. The landing gear on the "Spider" has been deployed. Inside the "Spider" were astronauts James A. McDivitt, Apollo 9 commander; and Russell L. Schweickart, lunar module pilot. Astronaut David R. Scott, command module pilot, remained at the controls in the Command Module (CM), "Gumdrop," while the other two astronauts checked out the LM.

STS-86 Mission Specialist David Wolf in white room

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 Mission Specialist David A. Wolf, at center facing camera, prepares to enter the Space Shuttle Atlantis at Launch Pad 39A, with the assistance of Rick Welty, in foreground at center, United Space Alliance (USA) orbiter vehicle closeout chief; and closeout team members, in background from left, Jim Davis, NASA quality assurance specialist; and George Schramm, USA mechanical technician. STS-86 Mission Specialist Vladimir Georgievich Titov, in foreground at far left, is awaiting his turn.

STS-69 Mission Commander David M. Walker arrives at SLF

NASA Technical Reports Server (NTRS)

1995-01-01

STS-69 Mission Commander David M. Walker arrives at KSC's Shuttle Landing Facility. Walker and four fellow crew members flew in from Johnson Space Center, Houston in the T-38 jet aircraft traditionally used by the astronaut corps. Later today, the countdown will begin as final preparations continue toward liftoff of the Space Shuttle Endeavour at 11:04 a.m. EDT, August 31 on STS-69.

Prescription for change: an interview with FDA Commissioner Dr. David Kessler.

PubMed

Kessler, D

1992-07-01

Dr David A. Kessler took over as Commissioner of the Food and Drug Administration in December 1990. Since then, he has initiated many changes to improve the structure and efficiency of the agency. In this interview, he describes some of the problems and challenges associated with the process of reviewing and approving new drugs.

Physics for Teachers: Understanding Physics: David Cassidy, Gerald Holton, & James Rutherford

NASA Astrophysics Data System (ADS)

Hubisz, John L.

2009-11-01

Physics for Teachers: Understanding Physics, by David Cassidy, Gerald Holton, & James Rutherford and published by Springer Verlag, New York, NY 10010 (2002), pp. xxiii + 851 80.00 hardback. ISBN 0-387-98756-8. Student Guide & Instructor Guide are also available. The text and Instructor Guide are available online at http://www.dcassidybooks.com/up.html

Chronicle of Higher Education. Volume 50, Number 44, July 9, 2004

ERIC Educational Resources Information Center

Chronicle of Higher Education, 2004

2004-01-01

"Chronicle of Higher Education" presents an abundant source of news and information for college and university faculty members and administrators. This July 9, 2004 issue of "Chronicle of Higher Education" includes the following articles: (1) "Learning Communities Can Be Cohesive-And Divisive" (Jaffee, David); (2)…

Simulating the Camp David Negotiations: A Problem-Solving Tool in Critical Pedagogy

ERIC Educational Resources Information Center

McMahon, Sean F.; Miller, Chris

2013-01-01

This article reflects critically on simulations. Building on the authors' experience simulating the Palestinian-Israeli-American Camp David negotiations of 2000, they argue that simulations are useful pedagogical tools that encourage creative--but not critical--thinking and constructivist learning. However, they can also have the deleterious…

Remapping Place and Narrative in Native American Literature: David Treuer's "The Hiawatha"

ERIC Educational Resources Information Center

Kirwan, Padraig

2007-01-01

David Treuer's 1997 novel, "The Hiawatha," engages the traditional literary strategies employed by Native American writing, compares those strategies to earlier narratives (Native American and canonically American), offers a reassessment of indigenous novelistic structures, engages critical responses to tribal fiction, and does so in response to…

Astronaut David Wolf participates in training for contingency EVA in WETF

NASA Technical Reports Server (NTRS)

1993-01-01

Astronaut David A. Wolf participates in training for contingency extravehicular activity (EVA) for the STS-58 mission. The mission specialist was about to be submerged to a point of neutral buoyancy in the JSC Weightless Environment Training Facility (WETF). In this view, Wolf is aided by technicians in donning the gloves for his extravehicular mobility unit (EMU).

A Response to David Kirk: Personal/Professional Views from US Authors

ERIC Educational Resources Information Center

Hastie, Peter; van der Mars, Hans

2014-01-01

This paper represents the views of two scholars in the USA with respect to the scholar lecture presented by David Kirk at the 2012 BERA -- Physical Education and Sport Pedagogy (PESP) Special Interest Group meeting. We discuss how two unique features of the American universities have an impact on both the corporate nature of our work and our…

Emblem - Apollo 9 Space Mission

NASA Image and Video Library

1969-02-06

S69-18569 (February 1969) --- The insignia of the Apollo 9 space mission. The crew consist of astronauts James A. McDivitt, commander; David R. Scott, command module pilot; and Russell L. Schweickart, lunar module pilot. The Apollo 9 mission will evaluate spacecraft lunar module systems performance during manned Earth-orbital flight. The NASA insignia design for Apollo flights is reserved for use by the astronauts and for other official use as the NASA Administrator may authorize. Public availability has been approved only in the form of illustrations by the various news media. When and if there is any change in this policy, which we do not anticipate, it will be publicly announced.

76 FR 39865 - Mr. David Creasey; Notice of Availability of Environmental Assessment

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 13829-001-ID] Mr. David... Policy Act of 1969 and the Federal Energy Regulatory Commission's regulations, 18 CFR Part 380 (Order No. 486, 52 FR 47897), the Office of Energy Projects has reviewed the application for an original license...

Dinner at Orazio's--David Triggle the model of a mentor.

PubMed

Smith, Susan L

2015-11-15

What does it mean to be a mentor in science? Definitions of mentorship are freely spouted in publications and include concepts such as academic support, professional development, role modeling, interaction, impartment of knowledge, evaluation of work, demonstration of methodology, etc. Perhaps most of us would agree with the duties listed. But just what does it mean, for example, to offer academic support? How might one facilitate professional development for a mentee? While we may agree to the general obligations of a mentor the specifics of what these entail would prove more controversial. This article will illustrate how easy it is to pick out a bad mentor. There are certain elements of conduct that, if practiced, undoubtedly put you in the "bad mentor" category. However, it is very difficult to explain just what it means to be not only an adequate mentor but also a stellar one. It may be easy to list the roles and responsibilities of a mentor but just how should they be performed/carried out? David Triggle is the model of an extraordinary mentor. The conclusion of this paper will focus on some specific mentorship activities David Triggle carried out that illustrate some of the intangible aspects of excellence in mentorship. Copyright © 2015 Elsevier Inc. All rights reserved.

Inflight - Apollo 9 (Crew Activities)

NASA Image and Video Library

1969-03-06

S69-26150 (6 March 1969) --- Television watchers on Earth saw this view of the Apollo 9 Command Module during the second live telecast from Apollo 9 early Thursday afternoon on the fourth day in space. This view is looking through the docking window of the Lunar Module. The cloud-covered Earth can be seen in the background. Inside the Lunar Module "Spider" were Astronauts James A. McDivitt, Apollo 9 commander; and Russell L. Schweickart, lunar module pilot. At this moment Apollo 9 was orbiting Earth with the Command and Service Modules docked nose-to-nose with the Lunar Module. Astronaut David R. Scott, command module pilot, remained at the controls in the Command Module "Gumdrop" while the other two astronauts checked out the Lunar Module. McDivitt and Schweickart moved into the Lunar Module from the Command Module by way of the docking tunnel.

Recovery- Apollo 9

NASA Image and Video Library

1969-03-13

S69-27468 (13 March 1969) --- U.S. Navy underwater demolition team swimmers assist the Apollo 9 crew during recovery operations just after splashdown. They have already attached a flotation collar to the Command Module (CM). Astronaut Russell L. Schweickart, lunar module pilot, is about to climb into raft. In background is astronaut David R. Scott, command module pilot. Still inside the spacecraft is astronaut James A. McDivitt, commander. Splashdown occurred at 12:00:53 p.m. (EST), March 13, 1969, only 4.5 nautical miles from the prime recovery ship, USS Guadalcanal, to conclude a successful 10-day Earth-orbital mission in space.

Obituary: David L. Band (1957-2009)

NASA Astrophysics Data System (ADS)

Cominsky, Lynn

2011-12-01

David L. Band, of Potomac Maryland, died on March 16, 2009 succumbing to a long battle with spinal cord cancer. His death at the age of 52 came as a shock to his many friends and colleagues in the physics and astronomy community. Band showed an early interest and exceptional aptitude for physics, leading to his acceptance at the Massachusetts Institute of Technology as an undergraduate student in 1975. After graduating from MIT with an undergraduate degree in Physics, Band continued as a graduate student in Physics at Harvard University. His emerging interest in Astrophysics led him to the Astronomy Department at the Harvard Smithsonian Center for Astrophysics (CfA), where he did his dissertation work with Jonathan Grindlay. His dissertation (1985) entitled "Non-thermal Radiation Mechanisms and Processes in SS433 and Active Galactic Nuclei" was "pioneering work on the physics of jets arising from black holes and models for their emission, including self-absorption, which previewed much to come, and even David's own later work on Gamma-ray Bursts," according to Grindlay who remained a personal friend and colleague of Band's. Following graduate school, Band held postdoctoral positions at the Lawrence Livermore Laboratory, the University of California at Berkeley and the Center for Astronomy and Space Sciences at the University of California San Diego where he worked on the BATSE experiment that was part of the Compton Gamma Ray Observatory (CGRO), launched in 1991. BATSE had as its main objective the study of cosmic gamma-ray bursts (GRBs) and made significant advances in this area of research. Band became a world-renowned figure in the emerging field of GRB studies. He is best known for his widely-used analytic form of gamma-ray burst spectra known as the "Band Function." After the CGRO mission ended, Band moved to the Los Alamos National Laboratory where he worked mainly on classified research but continued to work on GRB energetics and spectra. When NASA planned

Apollo 9 Lunar Module in lunar landing configuration

NASA Image and Video Library

1969-03-07

AS09-21-3199 (7 March 1969) --- Excellent view of the Apollo 9 Lunar Module, "Spider," in a lunar landing configuration, as photographed from the Command and Service Modules on the fifth day of the Apollo 9 Earth-orbital mission. The landing gear on the "Spider" has been deployed. Lunar surface probes (sensors) extend out from the landing gear foot pads. Inside the "Spider" were astronauts James A. McDivitt, Apollo 9 commander; and Russell L. Schweickart, lunar module pilot. Astronaut David R. Scott, command module pilot, remained at the controls in the Command Module, "Gumdrop," while the other two astronauts checked out the Lunar Module.

Apollo 9 Lunar Module in lunar landing configuration

NASA Image and Video Library

1969-03-07

AS09-21-3212 (7 March 1969) --- A view of the Apollo 9 Lunar Module (LM), "Spider", in a lunar landing configuration, as photographed from the Command and Service Modules (CSM) on the fifth day of the Apollo 9 Earth-orbital mission. The landing gear on the "Spider" has been deployed. Lunar surface probes (sensors) extend out from landing gear foot pads. Inside the "Spider" were astronauts James A. McDivitt, Apollo 9 commander, and Russell L. Schweickart, lunar module pilot. Astronaut David R. Scott, command module pilot, remained at the controls in the Command Module (CM), "Gumdrop", while the other two astronauts checked out the Lunar Module.

Discussion of David Thissen's Bad Questions: An Essay Involving Item Response Theory

ERIC Educational Resources Information Center

Ackerman, Terry

2016-01-01

In this commentary, University of North Carolina's associate dean of research and assessment at the School of Education Terry Ackerman poses questions and shares his thoughts on David Thissen's essay, "Bad Questions: An Essay Involving Item Response Theory" (this issue). Ackerman begins by considering the two purposes of Item Response…

47 CFR 9.7 - Access to 911 and E911 service capabilities.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 1 2013-10-01 2013-10-01 false Access to 911 and E911 service capabilities. 9.7 Section 9.7 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INTERCONNECTED VOICE OVER INTERNET PROTOCOL SERVICES § 9.7 Access to 911 and E911 service capabilities. (a) Access. Subject to the...

47 CFR 9.7 - Access to 911 and E911 service capabilities.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 1 2014-10-01 2014-10-01 false Access to 911 and E911 service capabilities. 9.7 Section 9.7 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INTERCONNECTED VOICE OVER INTERNET PROTOCOL SERVICES § 9.7 Access to 911 and E911 service capabilities. (a) Access. Subject to the...

47 CFR 9.7 - Access to 911 and E911 service capabilities.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 1 2012-10-01 2012-10-01 false Access to 911 and E911 service capabilities. 9.7 Section 9.7 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INTERCONNECTED VOICE OVER INTERNET PROTOCOL SERVICES § 9.7 Access to 911 and E911 service capabilities. (a) Access. Subject to the...

David crighton, 1942-2000: a commentary on his career and his influence on aeroacoustic theory

NASA Astrophysics Data System (ADS)

Ffowcs Williams, John E.

David Crighton, a greatly admired figure in fluid mechanics, Head of the Department of Applied Mathematics and Theoretical Physics at Cambridge, and Master of Jesus College, Cambridge, died at the peak of his career. He had made important contributions to the theory of waves generated by unsteady flow. Crighton's work was always characterized by the application of rigorous mathematical approximations to fluid mechanical idealizations of practically relevant problems. At the time of his death, he was certainly the most influential British applied mathematical figure, and his former collaborators and students form a strong school that continues his special style of mathematical application. Rigorous analysis of well-posed aeroacoustical problems was transformed by David Crighton.

STS-30 Commander David M. Walker during preflight press conference at JSC

NASA Technical Reports Server (NTRS)

1989-01-01

During preflight press conference, STS-30 Commander David M. Walker monitors a question from a news media representative. The event was held in the JSC Auditorium and Public Affairs Facility Bldg 2 briefing room. STS-30 mission will fly onboard Atlantis, Orbiter Vehicle (OV) 104, and is scheduled for an April 28 liftoff.

Education Policy, Globalization, Commercialization: An Interview with Bob Lingard by David Hursh

ERIC Educational Resources Information Center

Hursh, David

2017-01-01

In this interview with David Hursh, Bob Lingard comments on his current and/or recently completed research projects in respect to new modes of global governance in schooling and the complementarity between international large scale assessments and national testing. He also looks at a project that, in conjunction with school leaders, teachers,…

Laurance David Hall.

PubMed

Coxon, Bruce

2011-01-01

An account is given of the life, scientific contributions, and passing of Laurance David Hall (1938-2009), including his early history and education at the University of Bristol, UK, and the synthesis and NMR spectroscopy of carbohydrates and other natural products during ∼20 years of research and teaching at the University of British Columbia in Vancouver, Canada. Lists of graduate students, post-doctoral fellows, and sabbatical visitors are provided for this period. Following a generous endowment by Dr. Herchel Smith, Professor Hall built a new Department of Medicinal Chemistry at Cambridge University, UK, and greatly expanded his researches into the technology and applications of magnetic resonance imaging (MRI) and zero quantum NMR. MRI technology was applied both to medical problems such as the characterization of cartilage degeneration in knee joints, the measurement of ventricular function, lipid localization in animal models of atherosclerosis, paramagnetic metal complexes of polysaccharides as contrast agents, and studies of many other anatomical features, but also to several aspects of materials analysis, including food analyses, process control, and the elucidation of such physical phenomena as the flow of liquids through porous media, defects in concrete, and the visualization of fungal damage to wood. Professor Hall's many publications, patents, lectures, and honors and awards are described, and also his successful effort to keep the Asilomar facility in Pacific Grove, California as the alternating venue for the annual Experimental NMR Conference. Two memorial services for Professor Hall are remembered. Copyright © 2011 Elsevier Inc. All rights reserved.

Hot-spot residues at the E9/Im9 interface help binding via different mechanisms.

PubMed

Wong, Sergio E; Baron, Riccardo; McCammon, J Andrew

2008-11-01

Protein-protein association involves many interface interactions, but they do not contribute equally. Ala scanning experiments reveal that only a few mutations significantly lower binding affinity. These key residues, which appear to drive protein-protein association, are called hot-spot residues. Molecular dynamics simulations of the Colicin E9/Im9 complex show Im9 Glu41 and Im9 Ser50, both hot-spots, bind via different mechanisms. The results suggest that Im9 Ser50 restricts Glu41 in a conformation auspicious for salt-bridge formation across the interface. This type of model may be helpful in engineering hot-spot clusters at protein-protein interfaces and, consequently, the design of specificity.

David A. Wright in ER-2

NASA Image and Video Library

1999-10-27

David A. Wright is associate director for Center Operations at the NASA Dryden Flight Research Center, Edwards, Calif. He was formerly director of Flight Operations. He is also a research pilot, flying NASA's ER-2 and T-38. The ER-2s are civilian variants of the military U-2S reconnaissance aircraft and carry scientific instruments to study the Earth during worldwide deployments. Wright has more than 4,500 hours in six different aircraft. He held the position of deputy director of the Airborne Science Program at Dryden from 2002 until 2004. Wright came to Dryden after retiring from the U.S. Air Force as a lieutenant colonel. His final assignment was to the Joint Staff J3, Directorate of Operations at the Pentagon from November 1996 until August 1999. Prior to the Pentagon assignment, he served as commander of the 1st Reconnaissance Squadron at Beale Air Force Base near Marysville, Calif., the unit responsible for training all U-2 pilots. He was the operations officer for one the largest U-2 operations in history, flying combat missions against Iraq and managing an unprecedented U-2 flying schedule during the 1991 Desert Storm conflict. He was selected for the Air Force U-2 program in 1987 following duty as an aircraft commander in the E-3A AWACS (Airborne Warning and Control System) aircraft. Wright was a T-38 instructor for three years at Reese Air Force Base, Lubbock, Texas, following completion of pilot training in 1978. He graduated from the U.S. Air Force Academy in 1977 with a Bachelor of Science in mathematics and computer science. Wright earned a Master of Arts in Adult Education from Troy State University, Montgomery, Ala., in 1987, and a Master of Science in National Security and Strategic Studies from the Naval War College, Newport, R.I., in 1995.

Nighttime view of Apollo 9 space vehicle at Pad A, Launch Complex 39

NASA Image and Video Library

1969-02-23

S69-25879 (23 Feb. 1969) --- Nighttime view of the 363-feet-high Apollo 9 space vehicle at Pad A, Launch Complex 39, Kennedy Space Center, during preparations for the scheduled 10-day Earth-orbital space mission. The crew of the Apollo 9 (Spacecraft 104/Lunar Module 3/Saturn 504) space flight will be astronauts James A. McDivitt, David R. Scott, and Russell L. Schweickart.

Astronaut David Scott using Apollo Lunar Surface Drill during second EVA

NASA Image and Video Library

1971-08-01

S71-41501 (1 Aug. 1971) --- Astronaut David R. Scott, Apollo 15 commander, is seen carrying the Apollo Lunar Surface Drill (ALSD) during the second lunar surface extravehicular activity (EVA) in this black and white reproduction taken from a color transmission made by the RCA color television camera mounted on the Lunar Roving Vehicle (LRV). This transmission was the fourth made during the mission.

David Douglas Duncan's Changing Views on War: An Audio-Visual Presentation.

ERIC Educational Resources Information Center

Politowski, Richard

This paper is the script for a slide presentation about photographer David Douglas Duncan and his view of war. It is intended to be used with slides made from pictures Duncan took during World War II, the Korean War, and the war in Viet Nam and published in various books and periodicals. It discusses a shift in emphasis to be seen both in the…

APOLLO XII CREW - WELCOME - USS HORNET - REAR ADMIRAL DONALD DAVID

NASA Image and Video Library

1969-11-24

S69-22876 (24 Nov. 1969) --- Rear Admiral Donald C. David, Commander, Manned Spacecraft Recovery Force, Pacific, welcomes the crew of the Apollo 12 lunar landing mission aboard the USS Hornet, prime recovery vessel for the mission. A color guard was also on hand for the welcoming ceremonies. Inside the Mobile Quarantine Facility (MQF) are (left to right) astronauts Charles Conrad Jr., commander; Richard F. Gordon Jr., command module pilot; and Alan L. Bean, lunar module pilot.

Re-Coopering anti-psychiatry: David Cooper, revolutionary critic of psychiatry

PubMed Central

Chapman, Adrian

2016-01-01

This article offers an introduction to David Cooper (1931–86), who coined the term ‘anti-psychiatry’, and, it is argued here, has not so far received the scholarly attention that he deserves. The first section presents his life in context. The second section presents his work in detail. There follows a section on the critical reception of Cooper, and, finally, a conclusion that sets out ways in which he might be interesting and useful today. PMID:27909583

David Weston – DOE Early Career Research Program Award Winner

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weston, David

Plant biologist David Weston is one of this year's U.S. Department of Energy Early Career Research Program award recipients. With this award, he will identify the genes and metabolic functions involved in the exchange of nutrients between certain plants and microbes and study their response to environmental changes in both laboratory and field settings. Deeper fundamental understanding of the symbiotic plant-microbe relationship could reveal pathways to improve bioenergy crop production in nutrient-limiting environments.

My Martian Moment - Episode 1 - David Blake and CheMin

NASA Image and Video Library

2015-09-25

Ames' David Blake developed the Chemistry and Mineralogy instrument, or CheMin for short, which is currently operating on NASA's Curiosity Mars rover. It identifies and measures the abundance of various minerals on the Martian surface. The instrument is built around a highly compact X-ray diffraction unit, the first of its kind to operate on a planet besides Earth. CheMin can quickly analyze soil samples, helping scientists understand the composition and history of the Martian surface.

View of docked Apollo 9 Command/Service Module and Lunar Module

NASA Image and Video Library

1969-03-06

AS09-20-3064 (6 March 1969) --- Excellent view of the docked Apollo 9 Command and Service Modules (CSM) and Lunar Module (LM), with Earth in the background, during astronaut David R. Scott's stand-up extravehicular activity (EVA), on the fourth day of the Apollo 9 Earth-orbital mission. Scott, command module pilot, is standing in the open hatch of the Command Module (CM). Astronaut Russell L. Schweickart, lunar module pilot, took this photograph of Scott from the porch of the LM. Inside the LM was astronaut James A. McDivitt, Apollo 9 commander.

Beyond 2012: Why the World Won't End A Discussion with Dr. David Morrison

NASA Image and Video Library

2012-12-18

Dr. David Morrison, Astrobiologist and Senior Scientist at NASA Ames Research Center, addresses several theories that the world will end or face some kind of cosmic cataclysm on Friday December 21, 2012. Also known as the Doomsday Prophecy.

Portrait - Apollo 9 - Prime Crew - Cape

NASA Image and Video Library

1968-12-18

S68-56621 (18 Dec. 1968) --- These three astronauts are the prime crew of the Apollo 9 (Spacecraft 104/Lunar Module 3/Saturn 504) space mission. Left to right, are James A. McDivitt, commander; David R. Scott, command module pilot: and Russell L. Schweickart, lunar module pilot. The Apollo 9 launch is scheduled no earlier than February 28, 1969. In the background is the Apollo 8 space vehicle on Pad A, Launch Complex 39, Kennedy Space Center, which was launched on December 21, 1968. (Gaseous liquid oxygen is venting from the vehicle’s first [S-1C] stage during a countdown demonstration test). McDivitt holds a U.S. flag.

Dryden's David Bushman explains the capabilities of the Altus UAV to NASA Langley's Charles Hudgins

NASA Image and Video Library

2003-05-27

David Bushman, unmanned aerial vehicle (UAV) mission manager in NASA Dryden's Airborne Science Program, explains the capabilities of the Altus UAV to Charles Hudgins of NASA Langley's Chemistry and Dynamics Branch.

36th Annual David W. Smith Workshop on Malformations and Morphogenesis: Abstracts of the 2015 annual meeting.

PubMed

Gripp, Karen W; Adam, Margaret P; Hudgins, Louanne; Carey, John C

2016-07-01

The 36th Annual David W Smith Workshop on Malformations and Morphogenesis was held on August 14-19, 2015 at the Harbourtowne Conference Center in St. Michaels Maryland. The Workshop, which honors the legacy of David W Smith, brought together over 120 clinicians and researchers interested in congenital malformations and their underlying mechanisms of morphogenesis. As is the tradition of the meeting, the Workshop highlighted five themes besides mechanisms of morphogenesis: Rasopathies, Eye Malformations, Therapeutics, Prenatal Diagnosis, and Disorders of Sex Development. This Conference Report includes the abstracts presented at the 2015 Workshop. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Response to the Point of View of Gregory B. Pauly, David M. Hillis, and David C. Cannatella, by the Anuran Subcommittee of the SSAR/HL/ASIH Scientific and Standard English Names List

USGS Publications Warehouse

Frost, Darrel R.; McDiarmid, Roy W.; Mendelson, Joseph R.

2009-01-01

The Point of View by Gregory Pauly, David Hillis, and David Cannatella misrepresents the motives and activities of the anuran subcommittee of the Scientific and Standard English Names Committee, contains a number of misleading statements, omits evidence and references to critical literature that have already rejected or superseded their positions, and cloaks the limitations of their nomenclatural approach in ambiguous language. Their Point of View is not about promoting transparency in the process of constructing the English Names list, assuring that its taxonomy is adequately reviewed, or promoting nomenclatural stability in any global sense. Rather, their Point of View focuses in large part on a single publication, The Amphibian Tree of Life, which is formally unrelated to the Standard English Names List, and promotes an approach to nomenclature mistakenly asserted by them to be compatible with both the International Code of Zoological Nomenclature and one of its competitors, the PhyloCode.

STS-107 Mission Specialist David Brown suits up for TCDT

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-107 Mission Specialist David Brown happily submits to suit check prior to Terminal Countdown Demonstration Test activities, which include a simulated launch countdown at the pad. STS-107 is a mission devoted to research and will include more than 80 experiments that will study Earth and space science, advanced technology development, and astronaut health and safety. Launch is planned for Jan. 16, 2003, between 10 a.m. and 2 p.m. EST aboard Space Shuttle Columbia. .

STS-107 Mission Specialist David Brown suits up for TCDT

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-107 Mission Specialist David Brown waves as he completes suit check prior to Terminal Countdown Demonstration Test activities, which include a simulated launch countdown at the pad. STS-107 is a mission devoted to research and will include more than 80 experiments that will study Earth and space science, advanced technology development, and astronaut health and safety. Launch is planned for Jan. 16, 2003, between 10 a.m. and 2 p.m. EST aboard Space Shuttle Columbia. .

World's Youth Connect through Global Nomads Group: An Interview with GNG's David Macquart

ERIC Educational Resources Information Center

Morrison, James L.; Macquart, David

2006-01-01

Editor-in-chief James L. Morrison talks with David Macquart, co-founder of the Global Nomads Group (GNG), a group dedicated to improving children's cultural understanding by bringing the world into the classroom using videoconferencing technology. GNG moderates video conferences between K-12 classes in different countries, organizes virtual…

Apollo 9 Command Module aboard the U.S.S. Guadalcanal

NASA Image and Video Library

1969-03-13

S69-20239 (13 March 1969) --- Close-up view of the Apollo 9 Command Module (CM) as it sets on dolly on the deck of the USS Guadalcanal just after being hoisted from the water. The Apollo 9 spacecraft, with astronauts James A. McDivitt, David R. Scott, and Russell L. Schweickart aboard, splashed down at 12:00:53 p.m. (EST), March 13, 1969, only 4.5 nautical miles from the aircraft carrier to conclude a successful 10-day Earth-orbital mission in space.

Kinesthetic Appeals in the Poetic Structures of Contemporary Poetry: The Example of David Wagoner.

ERIC Educational Resources Information Center

Miller, Gail

1987-01-01

Examines David Wagoner's poetry to illustrate how interpreters can sensitize themselves to a poem's kinesthetic energy by attending to the physical cues of poetic structure such as sound and rhythmic patterns, line lengths and endings, typography, and tensions and resistances. (JD)

77 FR 67725 - Culturally Significant Object Imported for Exhibition Determinations: “Michelangelo's David Apollo”

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-13

... DEPARTMENT OF STATE [Public Notice 8085] Culturally Significant Object Imported for Exhibition Determinations: ``Michelangelo's David Apollo'' SUMMARY: Notice is hereby given of the following determinations... April 15, 2003), I hereby determine that the object to be included in the exhibition ``Michelangelo's...

Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes

PubMed Central

Gkogkas, Christos G.; Khoutorsky, Arkady; Cao, Ruifeng; Jafarnejad, Seyed Mehdi; Prager-Khoutorsky, Masha; Giannakas, Nikolaos; Kaminari, Archontia; Fragkouli, Apostolia; Nader, Karim; Price, Theodore J.; Konicek, Bruce W.; Graff, Jeremy R.; Tzinia, Athina K.; Lacaille, Jean-Claude; Sonenberg, Nahum

2015-01-01

SUMMARY Fragile X syndrome (FXS) is the leading genetic cause of autism. Mutations in Fmr1 (fragile X mental retardation 1 gene) engender exaggerated translation resulting in dendritic spine dysmorphogenesis, synaptic plasticity alterations, and behavioral deficits in mice, which are reminiscent of FXS pheno-types. Using postmortem brains from FXS patients and Fmr1 knockout mice (Fmr1 −/y), we show that phosphorylation of the mRNA 5′ cap binding protein, eukaryotic initiation factor 4E (eIF4E), is elevated concomitant with increased expression of matrix metalloproteinase 9 (MMP-9) protein. Genetic or pharmacological reduction of eIF4E phosphorylation rescued core behavioral deficits, synaptic plasticity alterations, and dendritic spine morphology defects via reducing exaggerated translation of Mmp9 mRNA in Fmr1 −/y mice, whereas MMP-9 overexpression produced several FXS-like phenotypes. These results uncover a mechanism of regulation of synaptic function by translational control of Mmp-9 in FXS, which opens the possibility of new treatment avenues for the diverse neurological and psychiatric aspects of FXS. PMID:25466251

Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes.

PubMed

Gkogkas, Christos G; Khoutorsky, Arkady; Cao, Ruifeng; Jafarnejad, Seyed Mehdi; Prager-Khoutorsky, Masha; Giannakas, Nikolaos; Kaminari, Archontia; Fragkouli, Apostolia; Nader, Karim; Price, Theodore J; Konicek, Bruce W; Graff, Jeremy R; Tzinia, Athina K; Lacaille, Jean-Claude; Sonenberg, Nahum

2014-12-11

Fragile X syndrome (FXS) is the leading genetic cause of autism. Mutations in Fmr1 (fragile X mental retardation 1 gene) engender exaggerated translation resulting in dendritic spine dysmorphogenesis, synaptic plasticity alterations, and behavioral deficits in mice, which are reminiscent of FXS phenotypes. Using postmortem brains from FXS patients and Fmr1 knockout mice (Fmr1(-/y)), we show that phosphorylation of the mRNA 5' cap binding protein, eukaryotic initiation factor 4E (eIF4E), is elevated concomitant with increased expression of matrix metalloproteinase 9 (MMP-9) protein. Genetic or pharmacological reduction of eIF4E phosphorylation rescued core behavioral deficits, synaptic plasticity alterations, and dendritic spine morphology defects via reducing exaggerated translation of Mmp9 mRNA in Fmr1(-/y) mice, whereas MMP-9 overexpression produced several FXS-like phenotypes. These results uncover a mechanism of regulation of synaptic function by translational control of Mmp-9 in FXS, which opens the possibility of new treatment avenues for the diverse neurological and psychiatric aspects of FXS. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

David J. Hofmann (1937-2009)

NASA Astrophysics Data System (ADS)

Deshler, Terry; Butler, James H.; Solomon, Susan; Barnes, John E.; Schnell, Russell C.

2009-12-01

David J. Hofmann, a pioneer in stratospheric aerosol and ozone research, passed away in Boulder, Colo., on 11 August 2009. He was 72. Dave, a frequent contributor to AGU publications and meetings, was elected an AGU Fellow in 2006. His long and prolific scientific career was, as he would say, simple in concept: Make a long-term commitment to specific measurements, pay attention to the details, and focus on the important issues that the measurements raise. This is simple in concept yet challenging to maintain in a world of short-term contracts and budgets. That Dave sustained and led key measurement programs through 25 years at the University of Wyoming (UW), in Laramie, and 17 years with the U.S. National Oceanic and Atmospheric Administration's (NOAA) Climate Monitoring and Diagnostics Laboratory (CMDL, which became the Global Monitoring Division (GMD) of NOAA's Earth System Research Laboratory) in Boulder, speaks volumes about the scientific and societal benefits that have resulted from his work. Most of the measurement programs he initiated, and the instruments he helped develop for them, continue today as testament to the value of his focus and lasting influence.

Unaware Memory in Hypothesis Generation Tasks

DTIC Science & Technology

1986-12-01

have been offered within the context of Tulving’s (1972) distinction between episodic and semantic memory systems (e.g., see Jacoby & - Witherspoon...in this direction (see Tulving, 1985) raise the possibility that neither episodic nor semantic memory systems can account for the type of unaware...material: Interactions with " episodic " and " semantic " memory . Conitive Psycholozv, 12, 227-251. Kolers, P. A. (1976). Reading a year later. Journal o

78 FR 76392 - Hours of Service of Drivers: Application for Exemption; David Muresan

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-17

...-0047] Hours of Service of Drivers: Application for Exemption; David Muresan AGENCY: Federal Motor... of service (HOS) rules. Mr. Muresan is a long-haul truck driver who teams with a second driver in... co-driver be permitted to operate under HOS rules that he has designed. He believes that his...

Calculating degree-based topological indices of dominating David derived networks

NASA Astrophysics Data System (ADS)

Ahmad, Muhammad Saeed; Nazeer, Waqas; Kang, Shin Min; Imran, Muhammad; Gao, Wei

2017-12-01

An important area of applied mathematics is the Chemical reaction network theory. The behavior of real world problems can be modeled by using this theory. Due to applications in theoretical chemistry and biochemistry, it has attracted researchers since its foundation. It also attracts pure mathematicians because it involves interesting mathematical structures. In this report, we compute newly defined topological indices, namely, Arithmetic-Geometric index (AG1 index), SK index, SK1 index, and SK2 index of the dominating David derived networks [1, 2, 3, 4, 5].

Apollo 9 prime crew participate in water egress training

NASA Image and Video Library

1968-11-01

S68-54859 (November 1968) --- The prime crew of the Apollo 9 (Spacecraft 104/Lunar Module 3/Saturn 504) space mission participates in water egress training in a tank in Building 260 at the Manned Spacecraft Center. Egressing the Apollo command module boilerplate is astronaut James A. McDivitt, commander. In life raft are astronauts David R. Scott (background), command module pilot; and Russell L. Schweickart, lunar module pilot.

Interview with the editor: David L. Turpin by Robert P. Scholz.

PubMed

Turpin, David L

2010-04-01

David L. Turpin has worked on dental journals for over 30 years--from his early days on the Pacific Coast Society of Orthodontists Bulletin, to the Angle Orthodontist, and to the American Journal of Orthodontics and Dentofacial Orthopedics. He will retire as editor-in-chief of the American Journal of Orthodontics and Dentofacial Orthopedics at the end of 2010. Copyright (c) 2010 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

Apollo 9 crew prepares to participate in Countdown Demonstration Test

NASA Image and Video Library

1969-02-23

S69-25488 (23 Feb. 1969) --- Interior view of the White Room at Pad A, Launch Complex 39, Kennedy Space Center (KSC), during an Apollo 9 Countdown Demonstration Test (CDDT). Astronauts James A. McDivitt, commander; David R. Scott, command module pilot; and Russell L. Schweickart, lunar module pilot, were participating in a dress rehearsal in preparation for their scheduled 10-day Earth-orbital space mission.

Finding Our Way Back to Healthy Eating: A Conversation with David A. Kessler

ERIC Educational Resources Information Center

Azzam, Amy M.

2009-01-01

In this interview, David Kessler, former commissioner of the Food and Drug Administration, explains why so many people overeat. Changing lifestyles promote the constant availability of food and around-the-clock eating. In today's highly processed foods, food companies are able to dial in the exact amount of fat, sugar, and salt that will make…

An Interview with David Rindskopf: A Leading Voice on Teaching Statistics and Methodology

ERIC Educational Resources Information Center

Bembenutty, Hefer

2011-01-01

This article presents an interview with David Rindskopf, a Distinguished Professor of Educational Psychology and Psychology at the City University of New York Graduate Center, where he has taught since 1979. His research and teaching are in the area of applied statistics, measurement, and research design. He is a fellow of the American Statistical…

Apollo 9 prime crew inside Apollo command module boilerplate during training

NASA Image and Video Library

1968-11-05

S68-54850 (5 Nov. 1968) --- The prime crew of the Apollo 9 (Spacecraft 104/Lunar Module 3/Saturn 504) space mission are seen inside an Apollo command module boilerplate during water egress training activity in the Gulf of Mexico. From foreground, are astronauts James A. McDivitt, commander; David R. Scott, command module pilot; and Russell L. Schweickart, lunar module pilot.

STS-86 Mission Specialist David Wolf suits up

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 Mission Specialist David A. Wolf gets assistance from a suit technician while donning his orange launch and entry suit in the Operations and Checkout Building. This will be Wolfs second flight. He and the six other crew members will depart shortly for Launch Pad 39A, where the Space Shuttle Atlantis awaits liftoff on a 10-day mission slated to be the seventh docking of the Space Shuttle with the Russian Space Station Mir. Wolf will transfer to the Mir 24 crew, replacing U.S. astronaut C. Michael Foale, who will return to Earth aboard Atlantis with the rest of the STS-86 crew. Wolf is expected to live and work aboard the Russian space station for about four months.

Apollo 9 crew prepares to cut cake on U.S.S. Guadalcanal

NASA Image and Video Library

1969-03-13

The Apollo 9 crew prepares to cut the 350-pound cake which was baked on the U.S.S. Guadalcanal in their honor. Left to right, are Astronauts Russell L. Schweickart, David R. Scott, and James A. McDivitt. Looking on at right is Capt. Roy M. Sudduth, commanding officer of the U.S.S. Guadalcanal.

Paul Voosen Receives 2013 David Perlman Award for Excellence in Science Journalism—News: Citation

NASA Astrophysics Data System (ADS)

Zaneski, Cyril T.

2014-01-01

It's my pleasure to nominate Paul Voosen, the former science reporter for Greenwire, for the David Perlman award. Last November, as Superstorm Sandy pounded the East Coast of the United States, Paul found himself stranded for several days in Miami, mourning a recently deceased family member.

Astronaut David Wolf participates in training for contingency EVA in WETF

NASA Technical Reports Server (NTRS)

1993-01-01

Astronaut David A. Wolf participates in training for contingency extravehicular activity (EVA) for the STS-58 mission. The mission specialist was about to be submerged ito a point of neutral buoyancy in the JSC Weightless Environment Training Facility (WETF). In this view, Wolf is displaying the flexibility of his training version of the Shuttle extravehicular mobility unit (EMU) by lifting his arms above his head (31701); Wolf waves to the camera before he is submerged in the WETF (31702).

Gold Medal Award for Life Achievement in the Application of Psychology: David W. Johnson.

PubMed

2016-01-01

The American Psychological Foundation (APF) Gold Medal Awards recognize distinguished and enduring records of accomplishment in four areas of psychology. The 2016 recipient of Gold Medal Award for Life Achievement in the Application of Psychology is David W. Johnson. Dorothy W. Cantor, president of the APF, will present the APF Gold Medal Awards at the 124th Annual Convention of the American Psychological Association on August 5, 2016, at 4:00 p.m. Members of the 2016 APF Board of Trustees are Dorothy W. Cantor, president; David H. Barlow, vice president; Melba J. T. Vasquez, secretary; Richard C. McCarty, treasurer; Elisabeth R. Straus, executive vice president/executive director; Cynthia Belar; Camilla Benbow; Rosie Phillips Bingham; Connie S. Chan; Anthony Jackson; Terence M. Keane; Archie L. Turner; W. Bruce Walsh; and Bonnie Markham and Rick McGraw, APA Board of Directors liaisons. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

The Camp David Ceremony and the Genre of the Presidential Parasocial Broadcast Announcement.

ERIC Educational Resources Information Center

Houser, William Evan

In 1978, the historic Camp David Peace Accords between Egypt and Israel were signed in a ceremony broadcast from the White House. The ceremony may be seen as a member of a rhetorical genre informally called the Presidential Parasocial Broadcast Announcement, but with a new twist. The genre has its roots in the Fireside Chats of Franklin D.…

Evaluation of the Oregon Business Council-David Douglas Model School District Partnership Program.

ERIC Educational Resources Information Center

Conley, David T.; Stone, Patricia

The Oregon Business Council (OBC)-David Douglas Model District Project was undertaken for two reasons: (1) to create a model for a district's accelerated implementation of all the elements of school reform as mandated in Oregon House Bill 3565; and (2) to learn lessons about school reform that would inform OBC member companies and school districts…

View of White Room atop Pad A during Apollo 9 Countdown Demonstration Test

NASA Image and Video Library

1969-02-23

S69-25884 (23 Feb. 1969) --- Interior view of the white room atop Pad A, Launch Complex 39, Kennedy Space Center, during Apollo 9 Countdown Demonstration Test activity. Standing next to spacecraft hatch is astronaut James A. McDivitt, commander. Also, taking part in the training exercise were astronauts David R. Scott, command module pilot; and Russell L. Schweickart, lunar module pilot. The Apollo 9 mission will evaluate spacecraft lunar module systems performance during manned Earth-orbital flight. Apollo 9 will be the second manned Saturn V mission.

Teaching 9/11 and the War on Terrorism. Footnotes. Volume 11, Number 1

ERIC Educational Resources Information Center

Kuehner, Trudy

2006-01-01

On October 15-16, 2005, FPRI's Marvin Wachman Fund for International Education hosted 45 teachers from 14 states across the country for a weekend of lectures and discussion on Teaching 9/11 and the War on Terrorism. Sessions included: (1) Presidential Leadership in Times of Crisis (David Eisenhower); (2) Terrorism in Historical and Comparative…

J. David Creswell: Award for Distinguished Scientific Early Career Contributions to Psychology.

PubMed

2014-11-01

APA's Awards for Distinguished Scientific Early Career Contributions to Psychology recognize excellent young psychologists who have not held a doctoral degree for more than nine years. One of the 2014 award winners is J. David Creswell, for "outstanding and innovative research on mechanisms linking stress management strategies to disease." Creswell's award citation, biography, and a selected bibliography are presented here. PsycINFO Database Record (c) 2014 APA, all rights reserved.

Dr. David Brown poses with a portrait of Ronald McNair

NASA Technical Reports Server (NTRS)

1999-01-01

In the gymnasium of Ronald McNair Magnet School in Cocoa, Fla., Dr. David Brown, a NASA astronaut, poses with a portrait of NASA astronaut Ronald McNair. The portrait was presented to the school by Walt Disney World during a tribute to McNair. The school had previously been renamed for the fallen astronaut who was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

The Archives of the History of American Psychology: An Interview with David B. Baker.

ERIC Educational Resources Information Center

Prieto, Loreto R.

2001-01-01

Presents an interview with David B. Baker, Director of the Archives of the History of American Psychology. Covers topics such as: Baker's interest in the history of psychology, his work at the Archives of the History of American Psychology, and recommendations for teachers when addressing history in non-history courses. (CMK)

STS-107 Crew Interviews: David Brown MS1

NASA Technical Reports Server (NTRS)

2002-01-01

STS-107 Mission Specialist 1 David Brown is seen during this preflight interview where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career. Brown outlines his role in the mission in general, and specifically during the conducting of on-board science experiments. Brown discusses the following instruments and experiments in detail: ARMS (Advanced Respiratory Monitoring System), MEIDEX (Mediterranean Israeli Dust Experiment), Combustion Module 2, and FREESTAR (Fast Reaction Enables Science Technology and Research). He also describes the new primary payload carrier, the SPACEHAB research double module which doubles the amount of space available for research. Brown shares his thoughts about the importance of international cooperation in mission planning and the need for scientific research in space.

For David and All Children with Autism: From a Father's and Researcher's Perspective

ERIC Educational Resources Information Center

Lowe, R. Sandlin, III

2008-01-01

In this article, the author shares his journey with autism which began when his son, David Braxton Hughes Lowe, was diagnosed in September of 2005. It was the confirmation of suspicions that he had had since he was about a year old. As a father and a physician, this was a particularly disheartening sequence of events. Over the next few months, he…

Recovery of handwritten text from the diaries and papers of David Livingstone

NASA Astrophysics Data System (ADS)

Knox, Keith T.; Easton, Roger L., Jr.; Christens-Barry, William A.; Boydston, Kenneth

2011-03-01

During his explorations of Africa, David Livingstone kept a diary and wrote letters about his experiences. Near the end of his travels, he ran out of paper and ink and began recording his thoughts on leftover newspaper with ink made from local seeds. These writings suffer from fading, from interference with the printed text and from bleed through of the handwriting on the other side of the paper, making them hard to read. New image processing techniques have been developed to deal with these papers to make Livingstone's handwriting available to the scholars to read. A scan of the David Livingstone's papers was made using a twelve-wavelength, multispectral imaging system. The wavelengths ranged from the ultraviolet to the near infrared. In these wavelengths, the three different types of writing behave differently, making them distinguishable from each other. So far, three methods have been used to recover Livingstone's handwriting. These include pseudocolor (to make the different writings distinguishable), spectral band ratios (to remove text that does not change), and principal components analysis (to separate the different writings). In initial trials, these techniques have been able to lift handwriting off printed text and have suppressed handwriting that has bled through from the other side of the paper.

View of White Room atop Pad A during Apollo 9 Countdown Demonstration Test

NASA Technical Reports Server (NTRS)

1969-01-01

Interior view of the White Room atop Pad A, Launch Complex 39, Kenndy Space Center, during Apollo 9 Countdown Demonstration Test activity. Standing next to spacecraft hatch is Astronaut James A. McDivitt, commander. Also taking part in the training exercise were Astronauts David R. Scott, command module pilot; and Russell L. Schweickart, lunar module pilot.

New software for computer-assisted dental-data matching in Disaster Victim Identification and long-term missing persons investigations: "DAVID Web".

PubMed

Clement, J G; Winship, V; Ceddia, J; Al-Amad, S; Morales, A; Hill, A J

2006-05-15

In 1997 an internally supported but unfunded pilot project at the Victorian Institute of Forensic Medicine (VIFM) Australia led to the development of a computer system which closely mimicked Interpol paperwork for the storage, later retrieval and tentative matching of the many AM and PM dental records that are often needed for rapid Disaster Victim Identification. The program was called "DAVID" (Disaster And Victim IDentification). It combined the skills of the VIFM Information Technology systems manager (VW), an experienced odontologist (JGC) and an expert database designer (JC); all current authors on this paper. Students did much of the writing of software to prescription from Monash University. The student group involved won an Australian Information Industry Award in recognition of the contribution the new software could have made to the DVI process. Unfortunately, the potential of the software was never realized because paradoxically the federal nature of Australia frequently thwarts uniformity of systems across the entire country. As a consequence, the final development of DAVID never took place. Given the recent problems encountered post-tsunami by the odontologists who were obliged to use the Plass Data system (Plass Data Software, Holbaek, Denmark) and with the impending risks imposed upon Victoria by the decision to host the Commonwealth Games in Melbourne during March 2006, funding was sought and obtained from the state government to update counter disaster preparedness at the VIFM. Some of these funds have been made available to upgrade and complete the DAVID project. In the wake of discussions between leading expert odontologists from around the world held in Geneva during July 2003 at the invitation of the International Committee of the Red Cross significant alterations to the initial design parameters of DAVID were proposed. This was part of broader discussions directed towards developing instruments which could be used by the ICRC's "The Missing

Apollo 9 Crewmen - Arrival - USS Guadalcanal

NASA Image and Video Library

1969-03-13

S69-20060 (13 March 1969) --- The Apollo 9 crewmen arrive aboard the USS Guadalcanal as they step from a helicopter to receive a red-carpet welcome. Two of the crewmen salute the crowd of newsmen, Navy and NASA personnel gathered to greet them. Left to right, are astronauts Russell L. Schweickart, lunar module pilot; David R. Scott (in back), command module pilot; and James A. McDivitt, commander. Splashdown occurred at 12:00:53 p.m. (EST), March 13, 1969, only 4.5 nautical miles from the USS Guadalcanal, prime recovery ship, to conclude a successful 10-day Earth-orbital space mission.

Inconvenient Truths: A Response to the Article by David Stoesz, "The Child Welfare Cartel"

ERIC Educational Resources Information Center

Clark, James J.; Yegidis, Bonnie L.

2016-01-01

David Stoesz offers a sweeping critique of the Children's Bureau and social work education by claiming the existence of a "child welfare cartel." He also attacks the quality of social work education and research, which he claims has poorly invested government funding and helped create the unmitigated failures of the American child…

Astronaut David Scott watching hammer and feather fall to lunar surface

NASA Technical Reports Server (NTRS)

1971-01-01

Astronaut David R. Scott, Apollo 15 commander, watches a geological hammer and a feather hit the lunar surface simultaneously in a test of Galileo's law of motion concerning falling bodies, as seen in this color reproduction taken from a transmission made by the RCA color television camera mounted on the Lunar Roving Vehicle. Scott released the hammer from his right hand and the feather from his left at the same instant. This experiment occured toward the end of the third and final lunar surface extravehicular activity.

9. Historic American Buildings Survey, Laurence E. Tilley, Photographer April, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Historic American Buildings Survey, Laurence E. Tilley, Photographer April, 1958 PALLADIAN WINDOW AT NORTH END OF CENTRAL HALL. 10. Historic American Buildings Survey, Laurence E. Tilley, Photographer April, 1958 CENTRAL VIEW OF DOUBLE PARLORS FROM SOUTHWEST PARLOR TOWARD NORTHWEST PARLOR. 11. Historic American Buildings Survey, Laurence E. Tilley, Photographer April, 1958 WALLPAPER IN SOUTHWEST PARLOR. 12. Historic American Buildings Survey, Laurence E. Tilley, Photographer April, 1958 FIREPLACE IN SOUTHWEST PARLOR. 13. Historic American Buildings Survey, Laurence E. Tilley, Photographer April, 1958 WINDOW IN SOUTHWEST PARLOR. 14. Historic American Buildings Survey, Laurence E. Tilley, Photographer April, 1958 DETAIL OF WALLPAPER AND WOODWORK IN ... - Eliza Ward House, 2 George Street, Providence, Providence County, RI

David Hume's Monetary Theory Revisited: Was He Really a Quantity Theorist and an Inflationist?

ERIC Educational Resources Information Center

Wennerlind, Carl

2005-01-01

David Hume's monetary theory has been controversial since its formulation. Lately, the focus has been on Hume's alleged misapplication of the quantity theory of money. While he appears to subscribe to a simple quantity theory with money neutrality, in a famously contested passage in the essay Of Money, he violates the neutrality condition by…

9. Historic American Buildings Survey E. W. Russell, Photographer, August ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Historic American Buildings Survey E. W. Russell, Photographer, August 4, 1936 CEILING AND CORNICE IN MAIN AUDITORIUM - Government Street Presbyterian Church, Government & Jackson Streets, Mobile, Mobile County, AL

9. Historic American Buildings Survey E. W. Russell, Photographer, February ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Historic American Buildings Survey E. W. Russell, Photographer, February 28, 1935 MAIN BUILDING (ADMINISTRATION) WEST - Spring Hill College, Main Building, Old Shell Road, Spring Hill, Mobile County, AL

Use of DAVID algorithms for gene functional classification in a non-model organism, rainbow trout

USDA-ARS?s Scientific Manuscript database

Gene functional clustering is essential in transcriptome data analysis but software programs are not always suitable for use with non-model species. The DAVID Gene Functional Classification Tool has been widely used for soft clustering in model species, but requires adaptations for use in non-model ...

David Cozad, Michael Schumacher and/or Brad Peterson (d/b/a Credit Island Recycling), Davenport, Iowa

EPA Pesticide Factsheets

The EPA is providing notice of proposed Administrative Penalty Assessment against David Cozad, Michael Schumacher and/or Brad Peterson (d/b/a Credit Island Recycling), for alleged violations of an industrial stormwater permit issued by IDNR for an applianc

Resident database interfaces to the DAVID system, a heterogeneous distributed database management system

NASA Technical Reports Server (NTRS)

Moroh, Marsha

1988-01-01

A methodology for building interfaces of resident database management systems to a heterogeneous distributed database management system under development at NASA, the DAVID system, was developed. The feasibility of that methodology was demonstrated by construction of the software necessary to perform the interface task. The interface terminology developed in the course of this research is presented. The work performed and the results are summarized.

David Farrar Mitchell: dental researcher & educator.

PubMed

Christen, Arden G; Christen, Joan A

2008-01-01

David Farrar Mitchell, DDS, PhD (1918-1975), was a pioneer in aviation dentistry and a leader in dental education, service and research. In the mid-1940's, he was the first dental officer assigned to the School of Aviation Medicine (SAM) in San Antonio, Texas, a unique, Army Air Corps organization for research and teaching. From 1942-1946, as a trained dental researcher and oral pathologist, he published works on dental problems afflicting military aviators, especially those associated with high altitude flying. His work greatly influenced ongoing dental treatment of military flyers. He served as faculty chairman of two dental schools: The University of Minnesota (1948-1955) and Indiana University (1955-1975). Of his 33 graduate students in oral pathology/medicine, 28 became department chairs at dental schools throughout the world. He was president of the American Academy of Oral Pathology (1962) and of the American Association for Dental Research (1975). From 1969 to 1975, he was editor of the prestigious Journal of Dental Research. During his professional career, Dr. Mitchell published 120 scientific articles on diverse topics relating to oral diagnosis and oral medicine.

9. Historic American Buildings Survey E. W. Russell, Photographer, June ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Historic American Buildings Survey E. W. Russell, Photographer, June 19, 1937 OLD SMOKEHOUSE (CONVERTED INTO GARAGE) LOOKING SLIGHTLY NORTHEAST. - Jenkins-Carlton-Autry House, County Road 52, Alpine, Talladega County, AL

Firing Room 2 in Launch Control Center at KSC during Apollo 9 countdown test

NASA Image and Video Library

1969-02-23

S69-25880 (23 Feb. 1969) --- Overall view of Firing Room 2 in the Launch Control Center, Launch Complex 39, Kennedy Space Center, during an Apollo 9 Countdown Demonstration Test. Astronauts James A. McDivitt, David R. Scott, and Russell L. Schweickart were participating in a training exercise in preparation for their scheduled 10-day Earth-orbital space mission.

Compilation of Reprints Number 58, Office of Naval Research.

DTIC Science & Technology

1981-09-01

ATLANTICA, GONOSTOMA ATLANTICUM, AND APHANOPUS CARBO, WITH NOTES ON THE ANATOMY OF APHANOPUS CARBO’ - ... Kevin M. Howe, David L. Stein and Carl E. Bond...REPORT NUMBR APHANOPUS CARBO 7. AUTHOR(. ) 8. CONTRACT OR GRANT NUMBER(@) Kevin M. Howe David L. Stein N00014-67-A-0369-007 Carl E. Bond 9...E Tyler. and C. R. Goldman Optical properties and show inTabe I or achof erlo’s 197] waer ype an 4922 ZANEVELD AND SPINRAD: IRRADIANCE IN THE SEA

(2E,6Z,9Z)-2,6,9-Pentadecatrienal as a Male-Produced Aggregation-Sex Pheromone of the Cerambycid Beetle Elaphidion mucronatum.

PubMed

Millar, Jocelyn G; Mitchell, Robert F; Meier, Linnea R; Johnson, Todd D; Mongold-Diers, Judith A; Hanks, Lawrence M

2017-12-01

An increasing body of evidence suggests that the volatile pheromones of cerambycid beetles are much more diverse in structure than previously hypothesized. Here, we describe the identification, synthesis, and field testing of (2E,6Z,9Z)-2,6,9-pentadecatrienal as a male-produced aggregation-sex pheromone of the cerambycid Elaphidion mucronatum (Say) (subfamily Cerambycinae, tribe Elaphidiini). This novel structure is unlike any previously described cerambycid pheromone, and in field bioassays attracted only this species. Males produced about 9 μg of pheromone per 24 h period, and, in field trials, lures loaded with 10, 25, and 100 mg of synthetic pheromone attracted beetles of both sexes, whereas lures loaded with 1 mg of pheromone or less were not significantly attractive. Other typical cerambycine pheromones such as 3-hydroxy-2-hexanone, syn-2,3-hexanediol, and anti-2,3-hexanediol were not attractive to E. mucronatum, and when combined with (2E,6Z,9Z)-2,6,9-pentadecatrienal, the former two compounds appeared to inhibit attraction. Unexpectedly, adults of the cerambycine Xylotrechus colonus (F.) were attracted in significant numbers to a blend of 3-hydroxyhexan-2-one and (2E,6Z,9Z)-2,6,9-pentadecatrienal, even though there is no evidence that this species produces the latter compound. From timed pheromone trap catches, adults of E. mucronatum were determined to be active from dusk until shortly after midnight.

David Kasner, MD, and the Road to Pars Plana Vitrectomy

PubMed Central

Blodi, Christopher F.

2016-01-01

David Kasner, MD (1927–2001), used his extensive dissections of eye bank eyes and experiences in teaching cataract surgery to resident physicians to realize that excision of vitreous when present in the anterior chamber of eyes undergoing cataract surgery was preferable to prior intraoperative procedures. Noting that eyes tolerated his maneuvers, he then performed planned subtotal open-sky vitrectomies; first on a traumatized eye in 1961, then on two eyes of patients with amyloidosis (1966–1967). The success of these operations was noted by others, most particularly Robert Machemer, MD. Kasner’s work directly led to further surgical developments, including closed pars plana vitrectomy. PMID:27660504

High-precision surface analysis of the roughness of Michelangelo's David

NASA Astrophysics Data System (ADS)

Fontana, Raffaella; Gambino, Maria Chiara; Greco, Marinella; Marras, Luciano; Materazzi, Marzia; Pampaloni, Enrico; Pezzati, Luca

2003-10-01

The knowledge of the shape of an artwork is an important element for its study and conservation. When dealing with a statue, roughness measurement is a very useful contribution to document its surface conditions, to assess either changes due to restoration intervention or surface decays due to wearing agents, and to monitor its time-evolution in terms of shape variations. In this work we present the preliminary results of the statistical analysis carried out on acquired data relative to six areas of the Michelangelo"s David marble statue, representative of differently degraded surfaces. Determination of the roughness and its relative characteristic wavelength is shown.

Incorporating a Cross-Cultural Perspective in the Undergraduate Psychology Curriculum: An Interview with David Matsumoto.

ERIC Educational Resources Information Center

Hill, G. William, IV

2000-01-01

Provides an interview with David Matsumoto, Professor of Psychology and Director of the Culture and Emotion Research Laboratory at San Francisco State University. He has studied emotion, human interaction, and culture for more than 15 years. Focuses on cross-cultural psychology and perspectives in relation to the psychology curriculum. (CMK)

STS-107 Flight Day 9 Highlights

NASA Technical Reports Server (NTRS)

2003-01-01

This video shows the activities of the STS-107 crew (Rick Husband, Commander; William McCool, Pilot; Kalpana Chawla, David Brown, Michael Anderson, Laurel Clark, Mission Specialists; Ilan Ramon, Payload Specialist) during flight day 9 of the Columbia orbiter's final flight. The primary activities of flight day 9 are spaceborne experiments. The video shows a commercial experiment on roses, a partial view of Africa from Libya to the Horn of Africa through the MEIDEX (Mediterranean Israeli Dust Experiment), and the FAST (Facility for Absorption and Surface Tension) experiment. The STARS (Space Technology and Research Students) international student experiments are shown. The preliminary results of these experiments on the effects of microgravity on silkworms, spiders, crystal growth, fish embryos, carpenter bees, and ants are discussed. The video includes a view of southern Spain and the Mediterranean Sea.

9. Historic American Buildings Survey, N. E. Baldwin, Photographer November ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Historic American Buildings Survey, N. E. Baldwin, Photographer November 1939, CUPBOARDS IN GUESTS' DINING ROOM, Gift of New York State Department of Education. - Shaker North Family, Dwelling House, Shaker Road, New Lebanon, Columbia County, NY

Latino Initiatives: Progress and Challenges. A Report by the Administration of Mayor David N. Dinkins.

ERIC Educational Resources Information Center

Medina, Adelita M.

This annual report for 1990 details initiatives by a select group of New York City (New York) agencies on matters of particular concern to Latinos. New York City's mayor, David Dinkins, originally presented these initiatives in August of 1990 to a meeting of Latino leaders representing diverse agencies and community organization. Highlights of…

Makers of Modern Science. Volume 9, Linus Pauling: Scientist and Advocate by David E. Newton

NASA Astrophysics Data System (ADS)

Kauffman, George B.; Kauffman, Laurie M.

1997-04-01

Facts on File: New York, 1994. 136 pp. Figs. and photos. 15.0 x 22.6 cm. $16.95 Makers of Modern Science, a series of biographies (available on standing order at a 20% discount), explores the lives and achievements of scientists who have made the greatest contributions to human knowledge during the 19th and 20th centuries. Each scientist's achievements, including underlying scientific principles, are discussed simply and clearly and are free of technical jargon. Drawing on primary sources such as diaries, memoirs, letters, and contemporary news stories, as well as secondary sources, each volume depicts the human drama of scientific work, the excitement and frustration of research, and the exhilaration and rewards of discovery. Each book, which includes black-and-white photographs, diagrams, an annotated bibliography, and a detailed index, contains a final chapter summarizing the legacy of the scientist's achievements.

Development and Testing of DAVID: A Close-in EMP Coupling Code for Arbitrarily Shaped Objects

DTIC Science & Technology

1975-11-07

5.OE-9 sec. (Ambient boundary condition, 0 = 0, Y - YAMAX ). 65 13 b. Approximate contours of constant Ex at T -5.8E-9 sec. (Ambient boundary...condition, 0 =0 Y -YMAX). 65 13 c. Appro<imate contours of constant Ex at T = 9.8E-9 sec. (Ambient boundary condition, 0 = 0 °, Y = YAMAX ). 66 13 d...Approximate contours of constant Ex at T 2.9E-8 sec. (Ambient boundary condition, 0% Y = YAMAX ). 66 - 14 a. Approximate contours of constant Ex at T = 9.8E-9

David Blackwell’s Forty Years in the Idaho Desert, The Foundation for 21st Century Geothermal Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

McLing, Travis; McCurry, Mike; Cannon, Cody

Dr. David Blackwell has had a profound influence on geo-thermal exploration and R&D in Idaho. Forty years have elapsed since the first Southern Methodist University (SMU) temperature logging truck rolled onto the high desert in Southern Idaho, yet even after so much time has elapsed, most recent and ongoing geothermal R&D can trace its roots to the foundational temperature studies led by Dr. Blackwell. We believe that the best way to honor any scientist is to see their work carried forward by others. As this paper demonstrates, it has been an easy task to find a host of Idaho researchersmore » and students eager to contribute to this tribute paper. We organize this paper by ongoing or recent projects that continue to benefit left to Idaho by Dr. David Blackwell.« less

Theorising "Geo-Identity" and David Harvey's Space: School Choices of the Geographically Bound Middle-Class

ERIC Educational Resources Information Center

Rowe, Emma

2015-01-01

This paper draws on David Harvey's theories of absolute and relational space in order to critique geographically bound school choices of the gentrified middle-class in the City of Melbourne, Australia. The paper relies on interviews with inner-city school choosers as generated by a longitudinal ethnographic school choice study. I argue that the…

David Kirk on Physical Education and Sport Pedagogy: In Dialogue with Steven Stolz (Part 1)

ERIC Educational Resources Information Center

Stolz, Steven A.; Kirk, David

2015-01-01

Forming the first of two articles, this dialogue begins from the dilemma posed in the writings of David Kirk that physical education is in crisis because the dominant practice of physical education as "sport-techniques" is resistant to change. In order to make sense of crisis discourse, the discussion explores the potential for change in…

STS-107 Mission Specialist David Brown arrives at KSC for TCDT

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-107 Mission Specialist David Brown arrives at KSC to take part in Terminal Countdown Demonstration Test activities, which include a simulated launch countdown. Other crew members are Commander Rick Husband, Pilot William 'Willie' McCool, Payload Commander Michael Anderson, Mission Specialists Kalpana Chawla and Laurel Clark and Payload Specialist Ilan Ramon (the first Israeli astronaut). STS-107 is a mission devoted to research and will include more than 80 experiments that will study Earth and space science, advanced technology development, and astronaut health and safety. Launch is scheduled for Jan. 16, 2003.

Imaging inert fluorinated gases in cracks: perhaps in David's ankles.

PubMed

Kuethe, Dean O; Scholz, Markus D; Fantazzini, Paola

2007-05-01

Inspired by the challenge of determining the nature of cracks on the ankles of Michelangelo's statue David, we discovered that one can image SF(6) gas in cracks in marble samples with alacrity. The imaging method produces images of gas with a signal-to-noise ratio (SNR) of 100-250, which is very high for magnetic resonance imaging (MRI) in general, let alone for an image of a gas at thermal equilibrium polarization. To put this unusual SNR in better perspective, we imaged SF(6) in a crack in a marble sample and imaged the lung tissue of a live rat (a more familiar variety of sample to many MRI scientists) using the same pulse sequence, the same size coils and the same MRI system. In both cases, we try to image subvoxel thin sheets of material that should appear bright against a darker background. By choosing imaging parameters appropriate for the different relaxation properties of SF(6) gas versus lung tissue and by choosing voxel sizes appropriate for the different goals of detecting subvoxel cracks on marble versus resolving subvoxel thin sheets of tissue, the SNR for voxels full of material was 220 and 14 for marble and lung, respectively. A major factor is that we chose large voxels to optimize SNR for detecting small cracks and we chose small voxels for resolving lung features at the expense of SNR. Imaging physics will cooperate to provide detection of small cracks on marble, but David's size poses a challenge for magnet designers. For the modest goal of imaging cracks in the left ankle, we desire a magnet with an approximately 32-cm gap and a flux density of approximately 0.36 T that weighs <500 kg.

STS-107 Mission Specialist David Brown during TCDT M113 training activities

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- -- STS-107 Mission Specialist David Brown takes a break during training on the operation of an M113 armored personnel carrier during Terminal Countdown Demonstration Test activities, a standard part of launch preparations. STS-107 is a mission devoted to research and will include more than 80 experiments that will study Earth and space science, advanced technology development, and astronaut health and safety. Launch is planned for Jan. 16, 2003, between 10 a.m. and 2 p.m. EST aboard Space Shuttle Columbia.

jsc2004e37689

NASA Image and Video Library

2004-08-18

JSC2004-E-37689 (18 August 2004) --- Astronaut Steven W. Lindsey, STS-121 commander, uses a climbing apparatus to lower himself from a simulated trouble-plagued shuttle in an emergency egress training session in the Space Vehicle Mockup Facility at the Johnson Space Center (JSC). Lindsey is wearing a training version of the shuttle launch and entry suit. United Space Alliance (USA) crew trainer David Pogue assisted Lindsey.

Being "Stresslessly Invisible": The Rise and Fall of Videophony in David Foster Wallace's "Infinite Jest"

ERIC Educational Resources Information Center

Ribbat, Christoph

2010-01-01

In a satiric chapter of David Foster Wallace's novel "Infinite Jest," a mock media expert reports how American consumers of the near future recoil from a new communication device known as "videophony" and return to the voice-only telephone of the Bell Era. This article explores the said chapter in the framework of media theories reading the…

44 CFR Appendix A to Part 9 - Decision-making Process for E.O. 11988

Code of Federal Regulations, 2010 CFR

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Decision-making Process for E.O. 11988 A Appendix A to Part 9 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT..., App. A Appendix A to Part 9—Decision-making Process for E.O. 11988 EC02FE91.074 ...

David Brock addresses the "How to Launch Your Business with NASA" forum.

NASA Image and Video Library

2017-10-18

The Morgan County Economic Development Association and the City of Decatur, in Partnership with the NASA/Marshall Space Flight Center (MSFC), hosted a business forum on, How to Launch Your Business with NASA, Wednesday, October 18, 2017, at the Alabama Center for the Arts in downtown Decatur, AL. The event was open to all businesses allowed them to connect with Senior NASA representatives and their prime contractors. The program guided businesses through the process of working with NASA as a supplier, subcontractor, and/or a service provider. The Marshall Space Flight Center’s projected procurement budget in FY 2018 is approximately $2.2 billion and numerous procurement opportunities are available for small business participation each fiscal year. The program included Todd May, Director of Marshall Space Flight Center; Johnny Stephenson, Director of Marshall Space Flight Center’s Office of Strategic Analysis and Communication; David Brock, Small Business Specialist with Marshall Space Flight Center; and Lynn Garrison, Small Business Specialist Technical Advisor with Marshall Space Flight Center. Additionally, there was a prime contractor panel consisting of representatives from five NASA prime contractors. The event included a dedicated networking session with those prime contractors. The “Launch Your Business With NASA” event provides those in attendance the opportunity to network with key Marshall Space Flight Center procurement and technical personnel, and representatives of several major Marshall Space Flight Center prime contractors.Arts.. David Brock, head of Marshall's Small Business Office talks about doing business with Marshall.

Dr. David Brown poses with students at Ronald McNair Middle School

NASA Technical Reports Server (NTRS)

1999-01-01

Dr. David Brown (right), a NASA astronaut, poses with students in the gymnasium of Ronald McNair Magnet School in Cocoa, Fla. From left, the students are Kristin Rexford, Danitra Anderson, Dominique Smith, Fallon Davis, and Qiana Taylor. Brown was at the school to attend a tribute to NASA astronaut Ronald McNair. The school had previously been renamed for the fallen astronaut who was one of a crew of seven, who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

9. Historic American Buildings Survey; Jack E. Boucher, photographer; Sept. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Historic American Buildings Survey; Jack E. Boucher, photographer; Sept. 1969 Copy of measured drawing, 1st floor plan, 1925 (From file of Wash. D.C. Board of Education, office of buildings and grounds) - Jackson (Public) School, R Street & Avon Place Northwest, Washington, District of Columbia, DC

ASTRONAUT SCOTT, DAVID R. - INTERIOR - WATER EGRESS TRAINING (GEMINI-TITAN [GT]-8 PRIME CREW) - MSC

NASA Image and Video Library

1966-01-05

S66-15743 (5 Jan. 1966) --- Astronaut David R. Scott, pilot of the Gemini-8 prime crew, undergoes water egress training in a special tank in building 260A at the Manned Spacecraft Center (MSC), Houston, Texas. An MSC swimmer assists in the training exercise. A boilerplate model of a Gemini spacecraft floats in the water beside Scott. Photo credit: NASA

International Approaches for Nuclear Waste Disposal in Geological Formations: Report on Fifth Worldwide Review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Faybishenko, Boris; Birkholzer, Jens; Persoff, Peter

2016-08-01

An important issue for present and future generations is the final disposal of spent nuclear fuel. Over the past over forty years, the development of technologies to isolate both spent nuclear fuel (SNF) and other high-level nuclear waste (HLW) generated at nuclear power plants and from production of defense materials, and low- and intermediate-level nuclear waste (LILW) in underground rock and sediments has been found to be a challenging undertaking. Finding an appropriate solution for the disposal of nuclear waste is an important issue for protection of the environment and public health, and it is a prerequisite for the futuremore » of nuclear power. The purpose of a deep geological repository for nuclear waste is to provide to future generations, protection against any harmful release of radioactive material, even after the memory of the repository may have been lost, and regardless of the technical knowledge of future generations. The results of a wide variety of investigations on the development of technology for radioactive waste isolation from 19 countries were published in the First Worldwide Review in 1991 (Witherspoon, 1991). The results of investigations from 26 countries were published in the Second Worldwide Review in 1996 (Witherspoon, 1996). The results from 32 countries were summarized in the Third Worldwide Review in 2001 (Witherspoon and Bodvarsson, 2001). The last compilation had results from 24 countries assembled in the Fourth Worldwide Review (WWR) on radioactive waste isolation (Witherspoon and Bodvarsson, 2006). Since publication of the last report in 2006, radioactive waste disposal approaches have continued to evolve, and there have been major developments in a number of national geological disposal programs. Significant experience has been obtained both in preparing and reviewing cases for the operational and long-term safety of proposed and operating repositories. Disposal of radioactive waste is a complex issue, not only because of

Enhanced integration of large DNA into E. coli chromosome by CRISPR/Cas9.

PubMed

Chung, Mu-En; Yeh, I-Hsin; Sung, Li-Yu; Wu, Meng-Ying; Chao, Yun-Peng; Ng, I-Son; Hu, Yu-Chen

2017-01-01

Metabolic engineering often necessitates chromosomal integration of multiple genes but integration of large genes into Escherichia coli remains difficult. CRISPR/Cas9 is an RNA-guided system which enables site-specific induction of double strand break (DSB) and programmable genome editing. Here, we hypothesized that CRISPR/Cas9-triggered DSB could enhance homologous recombination and augment integration of large DNA into E. coli chromosome. We demonstrated that CRISPR/Cas9 system was able to trigger DSB in >98% of cells, leading to subsequent cell death, and identified that mutagenic SOS response played roles in the cell survival. By optimizing experimental conditions and combining the λ-Red proteins and linear dsDNA, CRISPR/Cas9-induced DSB enabled homologous recombination of the donor DNA and replacement of lacZ gene in the MG1655 strain at efficiencies up to 99%, and allowed high fidelity, scarless integration of 2.4, 3.9, 5.4, and 7.0 kb DNA at efficiencies approaching 91%, 92%, 71%, and 61%, respectively. The CRISPR/Cas9-assisted gene integration also functioned in different E. coli strains including BL21 (DE3) and W albeit at different efficiencies. Taken together, our methodology facilitated precise integration of dsDNA as large as 7 kb into E. coli with efficiencies exceeding 60%, thus significantly ameliorating the editing efficiency and overcoming the size limit of integration using the commonly adopted recombineering approach. Biotechnol. Bioeng. 2017;114: 172-183. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Asymmetric Synthesis of 1,2,9,9a-Tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI)

PubMed Central

Lajiness, James P.; Boger, Dale L.

2011-01-01

A short, asymmetric synthesis of the 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI) analogue of the CC-1065 and duocarmycin DNA alkylation subunits is described. Treatment of iodo-epoxide 5, prepared by late-stage alkylation of 4 with (S)-glycidal-3-nosylate, with EtMgBr at room temperature directly provides the optically pure alcohol 6 in 87% yield (99% ee) derived from selective metal–halogen exchange and subsequent regioselective intramolecular 6-endo-tet cyclization. The use of MeMgBr or i-PrMgBr also provides the product in high yields (82–87%), but requires larger amounts of the Grignard reagent to effect metal–halogen exchange and cyclization. Direct transannular spirocyclization of 7 following O-debenzylation of 6 provides N-Boc-CBI. This approach represents the most efficient (9-steps, 31% overall) and effective (99% ee) route to the optically pure CBI alkylation subunit yet described. PMID:21192653

Preserving Precious Instruments in Mathematics History: The Educational Museum of Teachers College and David Eugene Smith's Collection

ERIC Educational Resources Information Center

Murray, Diane R.

2011-01-01

A history is given of the Educational Museum of Teachers College, which began in 1886, and David Eugene Smith's extensive collection of mathematical tools used in the Museum's exhibits is discussed. Historic mathematical instruments including, the astrolabe, abacus and counting rods, and the slide rule are examined. The author uses digitized…

Computer Center Harris 1600 Operator’s Guide.

DTIC Science & Technology

1982-06-01

RECIPIENT’S CATALOG NUMBER CMLD-82-15 Vb /9 7 ’ 4. TITLE (and Subtitle) S. TYPE OF REPORT & PERIOD COVERED Computer Center Harris 1600 Operator’s Guide...AD-AIAA 077 DAVID W TAYLOR NAVAL SHIP RESEARCH AND DEVELOPMENT CE--ETC F/G. 5/9 COMPUTER CENTER HARRIS 1600 OPEAATOR’S GUIDE.dU) M JUN 62 D A SOMMER...20084 COMPUTER CENTER HARRIS 1600 OPERATOR’s GUIDE by David V. Sommer & Sharon E. Good APPROVED FOR PUBLIC RELEASE: DISTRIBUTION UNLIMITED ’-.7 SJ0 o 0

Astronaut David Wolf participates in training for contingency EVA in WETF

NASA Image and Video Library

1993-04-03

S93-31706 (3 April 1993) --- With the aid of technicians and training staffers astronaut David A. Wolf prepares to participate in training for contingency Extravehicular Activity (EVA) for the STS-58 mission. Sharing a moveable platform with Wolf was astronaut Shannon W. Lucid (out of frame). For simulation purposes, the two mission specialists were about to be submerged to a point of neutral buoyancy in the Johnson Space Center's (JSC) Weightless Environment Training Facility (WET-F). Though the Spacelab Life Sciences (SLS-2) mission does not include a planned EVA, all crews designate members to learn proper procedures to perform outside the spacecraft in the event of failure of remote means to accomplish those tasks.

David Florida Laboratory: Support for mobile satellite communications

NASA Technical Reports Server (NTRS)

Dumoulin, Jean-Guy; Mamen, Rolf

1995-01-01

The comprehensive integration and environmental (including RF) test facilities of the Canadian Space Agency's David Florida Laboratory (CSA)(DFL) were used extensively for the MSAT Program. Following a description of the facilities, the paper outlines their application to the qualification of the two MSAT satellites following an overview of the test plan. Particular emphasis is given to passive intermodulation measurement (PIM) demands, which for the MSAT satellites, contributed to the need to extend the anechoic chamber. The extended chamber was also used for an EMC test and SAR signature test of the RADARSAT satellite. The DFL's facilities are being used for additional aspects of mobile satellite communications. One shielded anechoic Extra High Frequency (EHF) chamber and associated test equipment are employed predominantly for measuring the performance of the IRIDIUM satellites' Engineering Model Gateway Moveable Antennas (EM)(GMA). Other chambers are used for testing aeronautical antennas on behalf of Inmarsat. Still others combine thermal and PIM testing. The paper concludes with a review of the test requirements of evolving satcom missions such as Inmarsat Aero-1.

EDITORIAL: Van der Waals interactions in advanced materials, in memory of David C Langreth Van der Waals interactions in advanced materials, in memory of David C Langreth

NASA Astrophysics Data System (ADS)

Hyldgaard, Per; Rahman, Talat S.

2012-10-01

these collective plasmon excitations. The vdW-DF method thus seeks to utilise the implicit plasmon nature of the LDA/GGA success to also provide a nonempirical account of the fully nonlocal correlations that underpin the vdW bond [8]. The method retains a seamless integration [6] with the semilocal density functional components. We know that David was pleased to see how this quantitative, material-specific theory helped address problems in a broad class of materials that are sparse, i.e., that contain low electron density regions which are of significant consequence in determining material characteristics [9]. In a DFT framework, the vdW-DF method supplements other nonlocal functional descriptions [10] and the DFT-dispersion class of methods, extending GGA-DFT with an atom-based asymptotic description which relies on the vdW interaction coefficients [11]. The recent quest to understand the role of vdW forces in materials has certainly been facilitated and intensified by the set of recent developments in DFT itself. This is because these vdW-aware methods provide an opportunity to deliver a computationally effective account of the quantum-physical behavior even when the materials are sparse. It is the expectation that with such new-found theoretical capability, one may further extend the immense progress already attained by traditional (GGA) DFT calculations in reliably predicting the characteristics of materials and phenomena in materials, nanoscience, chemistry and other related fields [12]. This special issue contains a wealth of exciting contributions, mostly on vdW forces in materials. The special issue was suggested following the well-attended first focused vdW and materials session arranged by the Division of Materials Physics (DMP) of the American Physical Society (APS) at the March Meeting in 2011. The sad and unexpected passing of David in the spring of 2011 caused some rethinking and at the memorial symposium, held by David's colleagues at Rutgers in November

Apollo 9 crewmen arrive aboard U.S.S. Guadelcanal

NASA Image and Video Library

1969-03-13

S69-27921 (13 March 1969) --- The Apollo 9 crewmen arrive aboard the USS Guadalcanal as they step from a helicopter to receive a red-carpet welcome. Two of the crewmen salute the crowd of newsmen, Navy and NASA personnel gathered to greet them. Left to right, are astronauts Russell L. Schweickart, David R. Scott, and James A. McDivitt. Splashdown occurred at 12:00:53 p.m. (EST), March 13, 1969, only 4.5 nautical miles from the USS Guadalcanal, prime recovery ship, to conclude a successful 10-day Earth-orbital space mission. Photo credit: NASA

Best Practices Case Study: David Weekley Homes - Eagle Springs and Waterhaven, Houston, TX

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2011-04-01

Case study describing David Weekley Homes, Houston Division, has qualified more than 1,240 homes for the DOE Builders Challenge. Advanced framed 2x6 walls with open headers and two-stud corners allow more room for R-20 damp sprayed cellulose wall cavity insulation that is covered with R-5 rigid XPS foam. A radiant barrier cuts heat gain in the R-38 insulated vented attics. Draft stopping at fireplace and duct chases and behind tubs, gluing sheetrock to framing, and extensive caulking make for air-tight homes at 3.0 ACH50.

The Collision of Comet Shoemaker-Levy 9 and Jupiter

NASA Astrophysics Data System (ADS)

Noll, Keith S.; Weaver, Harold A.; Feldman, Paul D.

2006-11-01

Participants; Preface; 1. The orbital motion and impact circumstances of Comet Shoemaker-Levy 9 Paul W. Chodas and Donald K. Yeomans; 2. Observational constraints on the composition and nature of Comet D/Shoemaker-Levy 9 Jacques Crovisier; 3. Tidal breakup of the nucleus of Comet Shoemaker-Levy 9 Zdenek Sekanina; 4. Earth-based observations of impact phenomena Philip D. Nicholson; 5. HST imaging of Jupiter shortly after each impact: plumes and fresh sites Heidi B. Hammel; 6. Galileo observations of the impacts Clark R. Chapman; 7. Models of fragment penetration and fireball evolution David A. Crawford; 8. Entry and fireball models vs. observations: what have we learned? Mordecai-Mark Mac Low; 9. Dynamics and chemistry of SL9 plumes Kevin Zahnle; 10. Chemistry induced by the impacts: observations Emmanuel Lellouch; 11. SL9 impact chemistry: long-term photochemical evolution Julianne I. Moses; 12. Particulate matter in Jupiter's atmosphere from the impacts of Comet P/Shoemaker-Levy 9 Robert A. West; 13. Jupiter's post-impact atmospheric thermal response Barney J. Conrath; 14. Growth and dispersion of the Shoemaker-Levy 9 impact features from HST imaging Reta F. Beebe; 15. Waves from the Shoemaker-Levy 9 impacts Andrew P. Ingersoll and Hiroo Kanamori; 16. Jovian magnetospheric and auroral effects of the SL9 impacts Wing-Huen Ip.

President Carter’s Leadership at Camp David: Mediation as an Exercise in Strategic Thinking

DTIC Science & Technology

2011-03-24

longer about them, but about the health and welfare of the institution or perhaps the larger environment, including the community of nations.19 Leaders...President Carter was successful. President Sadat and Prime Minster Begin underscored their belief that the successful meeting Camp David was because of...experience is concerned, worked harder than the forefathers did in Egypt in building the pyramids.47 Prime Minster Begin also thanked Carter for

Religious Literacy or Spiritual Awareness? Comparative Critique of Andrew Wright's and David Hay's Approaches to Spiritual Education

ERIC Educational Resources Information Center

Filipsone, Anta

2009-01-01

On the basis of a comparison of the educational approaches of Andrew Wright and David Hay this paper illustrates the persisting problem of dichotomising cognitive and trans-cognitive aspects of spiritual development and education. Even though both Wright and Hay speak of the same topic--spirituality and spiritual education--they define these terms…

Measuring Success: David Conley's College Readiness Framework and the Illinois College and Career Readiness Act. In Brief

ERIC Educational Resources Information Center

Baber, Lorenzo D.; Castro, Erin L.; Bragg, Debra D.

2010-01-01

The purpose of this brief is to understand the Illinois College and Career Readiness (CCR) Act in light of David Conley's college readiness model. Although not mentioned specifically by the Illinois statute, evaluation results gathered by the Office of Community College Research and Leadership (OCCRL) show alignment between a number of programs…

Q&A: A Conversation With David France - The HIV/AID Plague Years and Where We Stand Now.

PubMed

Wehrwein, Peter

2017-02-01

Journalist David France's How to Survive A Plague is a searing firsthand account of the early years of the HIV/AIDS epidemic in New York City. AIDS activists, most of them gay men, were fighting for their lives. Researchers, politicians, public health officials, and pharma were slow to respond-or resisted outright.

Qualitative Research David Silverman Qualitative Research Sage Publications £26.99 464pp 9781849204170 1849204179 [Formula: see text].

PubMed

2012-01-26

DAVID SILVERMAN'S latest book builds on previous editions to provide up-to-date development in qualitative research and offers an overview of theoretical and practical considerations. Unlike many other qualitative research methodology books there is an emphasis on the function of qualitative research to articulate meaning.

David Malament and the Conventionality of Simultaneity: A Reply

NASA Astrophysics Data System (ADS)

Grünbaum, Adolf

2010-10-01

In 1977, David Malament proved the valuable technical result that the simultaneity relation of standard synchrony ɛ=1/2 with respect to an inertial observer O is uniquely definable in terms of the relation κ of causal connectibility. And he claimed that this definability undermines my own version of the conventionality of metrical simultaneity within an inertial frame. But Malament’s proof depends on the imposition of several supposedly “innocuous” constraints on any candidate for the simultaneity relation relative to O. Relying on Allen I. Janis’s 1983 challenge to one of these constraints, I argue that Malament’s technical result did not undermine my philosophical construal of the ontological status of relative metrical simultaneity. Furthermore, I show that (a) Michael Friedman’s peremptorily substantivalist critique of my conception, which Malament endorses, is ill-founded, and (b) if Malament had succeeded in discrediting my own conventionalist version of metrical simultaneity, he would likewise have invalidated Einstein’s pioneering version of it.

E6/E7 oncoproteins of high risk HPV-16 upregulate MT1-MMP, MMP-2 and MMP-9 and promote the migration of cervical cancer cells.

PubMed

Zhu, Dingjun; Ye, Mei; Zhang, Wei

2015-01-01

E6 and E7 of high risk human papillomavirus 16 (HPV16) were reported to correlate with the cervical cancer (CC). And the presence of matrix metalloproteinases (MMPs) has also been indicated to be associated with CC. The present study investigated the expression of MMPs (MT1-MMP, MMP-2 and MMP-9) in CC cells with HPV16-E6/E7 oncoprotein(s) negative or positive, and then determined the regulation of HPV16-E6/E7 oncoproteins on the expression of MMPs (MT1-MMP, MMP-2 and MMP-9) and the migration of cervical cancer Caski and SiHa cells with RNAi technology. It was demonstrated that the overexpression or the knockdown of HPV16-E6/E7 promoted or reduced MT1-MMP, MMP-2 and MMP-9 in CC cells. And the HPV16-E6, -E7 or -E6E7 influenced the migration of CC cells. The overexpression or the knockdown of them promoted or inhibited the migration of C33A or Caski/SiHa cells. Moreover, the chemical inhibition of MMP-2 or MMP-9 significantly reduced the migration of CC Caski or SiHa cells. Our results demonstrated that the E6-HPV16 or E7-HPV16 promoted the activity of MMP-2/9, and contributed to the migration of cervical cells.

Connor receives David Perlman Award for Excellence in Science Journalism-News: Response

NASA Astrophysics Data System (ADS)

Connor, Steve

2012-01-01

Steve Connor, science editor of the Independent newspaper of London, received the David Perlman Award for Excellence in Science Journalism-News at the AGU Fall Meeting Honors Ceremony, held on 7 December 2011 in San Francisco, Calif. Connor was honored for his article "Expect more extreme winters thanks to global warming, say scientists," published 24 December 2010 in theIndependent. The article covers a computer modeling study that found that losses in sea ice north of Scandinavia and Russia caused by global warming could paradoxically cause harsh, cold winters in the United Kingdom and elsewhere. The Perlman award is for work published with a deadline pressure of 1 week or less.

Connor receives David Perlman Award for Excellence in Science Journalism-News: Citation

NASA Astrophysics Data System (ADS)

Duff, Oliver

2012-01-01

Steve Connor, science editor of the Independent newspaper of London, received the David Perlman Award for Excellence in Science Journalism-News at the AGU Fall Meeting Honors Ceremony, held on 7 December 2011 in San Francisco, Calif. Connor was honored for his article "Expect more extreme winters thanks to global warming, say scientists," published 24 December 2010 in theIndependent. The article covers a computer modeling study that found that losses in sea ice north of Scandinavia and Russia caused by global warming could paradoxically cause harsh, cold winters in the United Kingdom and elsewhere. The Perlman award is for work published with a deadline pressure of 1 week or less.

PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE.

PubMed

Ason, Brandon; van der Hoorn, José W A; Chan, Joyce; Lee, Edward; Pieterman, Elsbet J; Nguyen, Kathy Khanh; Di, Mei; Shetterly, Susan; Tang, Jie; Yeh, Wen-Chen; Schwarz, Margrit; Jukema, J Wouter; Scott, Rob; Wasserman, Scott M; Princen, Hans M G; Jackson, Simon

2014-11-01

LDL cholesterol (LDL-C) contributes to coronary heart disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases LDL-C by inhibiting LDL-C clearance. The therapeutic potential for PCSK9 inhibitors is highlighted by the fact that PCSK9 loss-of-function carriers exhibit 15-30% lower circulating LDL-C and a disproportionately lower risk (47-88%) of experiencing a cardiovascular event. Here, we utilized pcsk9(-/-) mice and an anti-PCSK9 antibody to study the role of the LDL receptor (LDLR) and ApoE in PCSK9-mediated regulation of plasma cholesterol and atherosclerotic lesion development. We found that circulating cholesterol and atherosclerotic lesions were minimally modified in pcsk9(-/-) mice on either an LDLR- or ApoE-deficient background. Acute administration of an anti-PCSK9 antibody did not reduce circulating cholesterol in an ApoE-deficient background, but did reduce circulating cholesterol (-45%) and TGs (-36%) in APOE*3Leiden.cholesteryl ester transfer protein (CETP) mice, which contain mouse ApoE, human mutant APOE3*Leiden, and a functional LDLR. Chronic anti-PCSK9 antibody treatment in APOE*3Leiden.CETP mice resulted in a significant reduction in atherosclerotic lesion area (-91%) and reduced lesion complexity. Taken together, these results indicate that both LDLR and ApoE are required for PCSK9 inhibitor-mediated reductions in atherosclerosis, as both are needed to increase hepatic LDLR expression. Copyright © 2014 by the American Society for Biochemistry and Molecular Biology, Inc.

Astronaut David Wolf participates in training for contingency EVA in WETF

NASA Image and Video Library

1993-04-03

S93-31701 (3 April 1993) --- Displaying the flexibility of his training version of the Shuttle Extravehicular Mobility Unit (EMU) space suit, astronaut David A. Wolf participates in training for contingency Extravehicular Activity (EVA) for the STS-58 mission. Behind Wolf, sharing the platform with him was astronaut Shannon W. Lucid. For simulation purposes, the two mission specialists were about to be submerged to a point of neutral buoyancy in the Johnson Space Center's (JSC) Weightless Environment Training Facility (WET-F). Though the Spacelab Life Sciences (SLS-2) mission does not include a planned EVA, all crews designate members to learn proper procedures to perform outside the spacecraft in the event of failure of remote means to accomplish those tasks.

UV Radiation Activates Toll-Like Receptor 9 Expression in Primary Human Keratinocytes, an Event Inhibited by Human Papillomavirus 38 E6 and E7 Oncoproteins.

PubMed

Pacini, Laura; Ceraolo, Maria Grazia; Venuti, Assunta; Melita, Giusi; Hasan, Uzma A; Accardi, Rosita; Tommasino, Massimo

2017-10-01

Several lines of evidence indicate that cutaneous human papillomavirus (HPV) types belonging to the beta genus of the HPV phylogenetic tree synergize with UV radiation in the development of skin cancer. Accordingly, the E6 and E7 oncoproteins from some beta HPV types are able to deregulate pathways related to immune response and cellular transformation. Toll-like receptor 9 (TLR9), in addition to playing a role in innate immunity, has been shown to be involved in the cellular stress response. Using primary human keratinocytes as experimental models, we have shown that UV irradiation (and other cellular stresses) activates TLR9 expression. This event is closely linked to p53 activation. Silencing the expression of p53 or deleting its encoding gene affected the activation of TLR9 expression after UV irradiation. Using various strategies, we have also shown that the transcription factors p53 and c-Jun are recruited onto a specific region of the TLR9 promoter after UV irradiation. Importantly, the E6 and E7 oncoproteins from beta HPV38, by inducing the accumulation of the p53 antagonist ΔNp73α, prevent the UV-mediated recruitment of these transcription factors onto the TLR9 promoter, with subsequent impairment of TLR9 gene expression. This study provides new insight into the mechanism that mediates TLR9 upregulation in response to cellular stresses. In addition, we show that HPV38 E6 and E7 are able to interfere with this mechanism, providing another explanation for the possible cooperation of beta HPV types with UV radiation in skin carcinogenesis. IMPORTANCE Beta HPV types have been suggested to act as cofactors in UV-induced skin carcinogenesis by altering several cellular mechanisms activated by UV radiation. We show that the expression of TLR9, a sensor of damage-associated molecular patterns produced during cellular stress, is activated by UV radiation in primary human keratinocytes (PHKs). Two transcription factors known to be activated by UV radiation, p53

The challenges and future of oral drug delivery: An interview with David Brayden.

PubMed

Brayden, David J

2016-12-01

David Brayden speaks to Hannah Makin, Commissioning Editor: David Brayden is a Full Professor (Advanced Drug Delivery) at the School of Veterinary Medicine, University College Dublin (UCD) and also a Fellow of the UCD Conway Institute. Following a PhD in Pharmacology at the University of Cambridge, UK (1989), and a postdoctoral research fellowship at Stanford University, CA, USA, he set up Elan Biotechnology Research's in vitro pharmacology laboratory in Dublin (1991). At Elan, he became a senior scientist and project manager of several of Elan's joint-venture drug delivery research collaborations with US biotech companies. In 2001, he joined UCD as a lecturer in veterinary pharmacology and was appointed Associate Professor in 2006 and Full Professor in 2014. He was a Director of the Science Foundation Ireland Research Cluster (The Irish Drug Delivery Research Network) from 2007 to 2013, is a Deputy Coordinator of an FP7 Consortium on oral peptides in nanoparticles ('TRANS-INT', 2012-2017), and is a Co-Principal Investigator in 'CURAM', Science Foundation Ireland's new Centre for Medical Devices (2014-2020 [ 1 ]). He was made a Fellow of the Controlled Release Society in 2012. He is the author or co-author of >200 research publications and patents. D Brayden serves on the Editorial Advisory Boards of Drug Discovery Today, European Journal of Pharmaceutical Sciences, Advanced Drug Delivery Reviews and the Journal of Veterinary Pharmacology and Therapeutics, and is an Associate Editor of Therapeutic Delivery. D Brayden works as an independent consultant for drug delivery companies.

2011 Joint Program Executive Office for Chemical and Biological Defense Advance Planning Briefing for Industry (APBI) Held in Baltimore, Maryland on September 7-9, 2011

DTIC Science & Technology

2011-09-09

Chemical and Biological Defense Defense Threat Reduction Agency (DTRA)/Joint Science & Technology Office (JSTO) Dr. Alan Rudolph , Director, Chemical...Mr. Douglas W. Bryce 9:05 am – 9:45 am Dr. Alan Rudolph Director, Chemical and Biological Technologies Directorate, Defense Threat Reduction...Joint Science and Technology Office for Chemical and Biological Defense Dr. Alan S. Rudolph Mr. David K. Grimm Acting Heidi Shyu Joint Combat

ACCURATE MEASUREMENT OF THE ENERGY DEPENDENCE OF THE PROCESS e+ + e- → e± + e∓, IN THE s-RANGE 1.44-9.0 GeV2

NASA Astrophysics Data System (ADS)

Bernardini, M.; Bollini, D.; Brunini, P. L.; Fiorentino, E.; Massam, T.; Monari, L.; Palmonari, F.; Rimondi, F.; Zichichi, A.

The analysis of 12 827 e+ + e- → e± + e∓ events observed in the s-range 1.44-9.0 GeV2 allows measurement of the energy dependence of the cross-section for the most typical QED process, with ±2% accuracy. Within this limit the data follow QED, with first-order radiative corrections included.

PEOPLE IN PHYSICS: David Bohm and the implicate order: a new paradigm for physics teachers

NASA Astrophysics Data System (ADS)

Bettany, Laurence

1998-11-01

David Bohm (1917-93) was a highly original and individual physicist. His novel ideas and profound intuition extended not only to the physical world but also to the nature of consciousness and society. Bohm regarded science as having become essentially fragmented in its approach to understanding physical reality and sought a more holistic physics based on order, transformation and flowing movement. His notion of an implicate order provides an unusual and exciting challenge for both teachers and students alike.

Implementing Community Engagement as a Mission at the David Geffen School of Medicine at the University of California, Los Angeles.

PubMed

Chung, Bowen; Brown, Arleen; Moreno, Gerardo; Cuen, Pattie; Uy, Visith; Vangala, Sitaram; Bell, Douglas; Washington, A Eugene; Norris, Keith C; Mangione, Carol

2016-02-01

This manuscript describes the development and implementation of community engagement as a mission at UCLA's David Geffen School of Medicine (DGSOM) and UCLA Health System, and summarizes survey results documenting existing community-engaged projects and interest between 2010 to 2013.

David Bushman at the Mission Manager's console onboard NASA's DC-8 during the AirSAR 2004 campaign

NASA Image and Video Library

2004-03-03

David Bushman at the Mission Manager's console onboard NASA's DC-8 during the AirSAR 2004 campaign. AirSAR 2004 is a three-week expedition by an international team of scientists that will use an all-weather imaging tool, called the Airborne Synthetic Aperture Radar (AirSAR), in a mission ranging from the tropical rain forests of Central America to frigid Antarctica.

Drones of the dwarf honey bee Apis florea are attracted to (2E)-9-oxodecenoic acid and (2E)-10-hydroxydecenoic acid.

PubMed

Nagaraja, Narayanappa; Brockmann, Axel

2009-06-01

The queen mandibular gland component (2E)-9-oxodecenoic acid (9-ODA) has been suggested to function as the major sex pheromone component in all honey bee species. In contrast to this hypothesis, chemical analyses showed that in the Asian dwarf honey bee species, Apis florea, a different decenoic acid, (2E)-10-hydroxydecenoic acid (10-HDA), is the major component in the mandibular gland secretion. We show here that A. florea drones are attracted to 9-ODA as well as to 10-HDA. However, 10-HDA attracted higher numbers of drones at lower dosages than 9-ODA, and also was more attractive when directly compared to 9-ODA in a dual attraction experiment. We conclude that 10-HDA has to be viewed as the major sex pheromone in A. florea. The result that both pheromone components are capable of attracting drones when presented alone was unexpected with regard to existing sex pheromone attraction experiments in honey bees.

Astronaut David Scott gives salute beside U.S. flag during EVA

NASA Image and Video Library

1971-08-01

AS15-88-11863 (1 Aug. 1971) --- Astronaut David R. Scott, commander, gives a military salute while standing beside the deployed United States flag during the Apollo 15 lunar surface extravehicular activity (EVA) at the Hadley-Apennine landing site. The flag was deployed toward the end of EVA-2. The Lunar Module (LM), "Falcon," is partially visible on the right. Hadley Delta in the background rises approximately 4,000 meters (about 13,124 feet) above the plain. The base of the mountain is approximately 5 kilometers (about three statue miles) away. This photograph was taken by astronaut James B. Irwin, lunar module pilot. While astronauts Scott and Irwin descended in the LM to explore the moon, astronaut Alfred M. Worden, command module pilot, remained in lunar orbit in the Command and Service Modules (CSM).

Apollo 9 prime crew participates in water egress training in Gulf of Mexico

NASA Technical Reports Server (NTRS)

1968-01-01

The Apollo 9 prime crew participates in water egress training in the Gulf of Mexico. Being hoisted up to the U.S. Coast Guard helicopter in a new type of rescue net (called a Billy Pugh net) is Astronaut David R. Scott, command module pilot. Sitting in the life raft awaiting their turn for helicopter pickup are Astronauts Russell L. Schweickart (on left), lunar module pilot; and James A. McDivitt, commander. A team of Manned Spacecraft Center (MSC) swimmers assisted in the training exercise.

Apollo 9 prime crew on deck of ship prior to water egress training

NASA Image and Video Library

1968-11-05

S68-54841 (5 Nov. 1968) --- The prime crew of the Apollo 9 (Spacecraft 104/Lunar Module 3/Saturn 504) space mission stands on the deck of the NASA Motor Vessel Retriever (MVR) prior to participating in water egress training in the Gulf of Mexico. Left to right, are astronauts Russell L. Schweickart, lunar module pilot; David R. Scott, command module pilot; and James A. McDivitt, commander. In background is the Apollo Command Module (CM) boilerplate which was used in the training exercise.

jsc2018e048511

NASA Image and Video Library

2018-05-14

jsc2018e048511 - Expedition 56 backup crewmember David Saint-Jacques of the Canadian Space Agency poses for pictures in the Kremlin gardens in Moscow May 14 as part of traditional pre-launch activities. Saint-Jacques is serving as a backup to the prime crew, Serena Aunon-Chancellor of NASA, Sergey Prokopyev of Roscosmos and Alexander Gerst of the European Space Agency, who will launch June 6 from the Baikonur Cosmodrome in Kazakhstan on the Soyuz MS-09 spacecraft for a six month mission on the International Space Station...NASA/Elizabeth Weissinger.

Implementing Community Engagement as a Mission at the David Geffen School of Medicine at the University of California, Los Angeles

PubMed Central

Chung, Bowen; Brown, Arleen; Moreno, Gerardo; Cuen, Pattie; Uy, Visith; Vangala, Sitaram; Bell, Douglas; Washington, A. Eugene; Norris, Keith C.; Mangione, Carol

2015-01-01

Summary This manuscript describes the development and implementation of community engagement as a mission at UCLA’s David Geffen School of Medicine (DGSOM) and UCLA Health System, and summarizes survey results documenting existing community-engaged projects and interest between 2010 to 2013. PMID:27158216

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Annaval, Thibault; Rudolf, Jeffrey D.; Chang, Chin-Yuan

Enediynes are potent natural product anticancer antibiotics, and are classified as 9- or 10-membered according to the size of their enediyne core carbon skeleton. Both 9- and 10-membered enediyne cores are biosynthesized by the enediyne polyketide synthase (PKSE), thioesterase (TE), and PKSE-associated enzymes. Though the divergence between 9- and 10-membered enediyne core biosynthesis remains unclear, it has been observed that nascent polyketide intermediates, tethered to the acyl carrier protein (ACP) domain of PKSE, could be released by TE in the absence of the PKSE-associated enzymes. Here, we determined the crystal structure of SgcE10, the TE that participates in the biosynthesismore » of the 9-membered enediyne C-1027. Structural comparison of SgcE10 with CalE7 and DynE7, two TEs that participate in the biosynthesis of the 10-membered enediynes calicheamicin and dynemicin, respectively, revealed that they share a common α/β hot-dog fold. The amino acids involved in both substrate binding and catalysis are conserved among SgcE10, CalE7, and DynE7. The volume and the shape of the substrate-binding channel and active site in SgcE10, CalE7, and DynE7 confirm that TEs from both 9- and 10-membered enediyne biosynthetic machineries bind the linear form of similar ACP-tethered polyene intermediates. Taken together, our findings further support the proposal that the divergence between 9- and 10-membered enediyne core biosynthesis occurs beyond PKSE and TE catalysis.« less

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis

DOE PAGES

Annaval, Thibault; Rudolf, Jeffrey D.; Chang, Chin-Yuan; ...

2017-08-30

Enediynes are potent natural product anticancer antibiotics, and are classified as 9- or 10-membered according to the size of their enediyne core carbon skeleton. Both 9- and 10-membered enediyne cores are biosynthesized by the enediyne polyketide synthase (PKSE), thioesterase (TE), and PKSE-associated enzymes. Though the divergence between 9- and 10-membered enediyne core biosynthesis remains unclear, it has been observed that nascent polyketide intermediates, tethered to the acyl carrier protein (ACP) domain of PKSE, could be released by TE in the absence of the PKSE-associated enzymes. Here, we determined the crystal structure of SgcE10, the TE that participates in the biosynthesismore » of the 9-membered enediyne C-1027. Structural comparison of SgcE10 with CalE7 and DynE7, two TEs that participate in the biosynthesis of the 10-membered enediynes calicheamicin and dynemicin, respectively, revealed that they share a common α/β hot-dog fold. The amino acids involved in both substrate binding and catalysis are conserved among SgcE10, CalE7, and DynE7. The volume and the shape of the substrate-binding channel and active site in SgcE10, CalE7, and DynE7 confirm that TEs from both 9- and 10-membered enediyne biosynthetic machineries bind the linear form of similar ACP-tethered polyene intermediates. Taken together, our findings further support the proposal that the divergence between 9- and 10-membered enediyne core biosynthesis occurs beyond PKSE and TE catalysis.« less

Obituary: David Q. Wark, 1918-2002

NASA Astrophysics Data System (ADS)

McMillin, Larry Max

2003-12-01

David Q. Wark, a research meteorologist at the National Environmental Satellite, Data, and Information Service of the National Oceanic and Atmospheric Administration (NOAA/NESDIS) and its predecessor organizations for 55 years, died of cancer 30 July 2002. He will be long remembered for his seminal contributions to the weather satellite program. A pioneer in the use of satellite sensors to provide observations of the Earth's environment for application to weather forecasting and atmospheric science, Dr. Wark was noted for his brilliant insights, dedication, and exceptional scientific achievements. He developed many of the theoretical and experimental techniques on which NOAA's current multi- billion-dollar meteorological satellite program is based. In the 1960's and early 1970's, he and his NOAA colleague Donald Hilleary were the motivating force and principal investigators for the first satellite instruments dedicated to sounding the atmosphere for temperature and water-vapor. These instruments included the Satellite Infra-Red Spectrometer (SIRS)-A and -B and the Vertical Temperature Profile Radiometer (VTPR), which were flown on NASA's Nimbus satellites and NOAA's ITOS-D satellites, respectively. With colleague Henry Fleming, he formulated the radiative transfer equation that quantifies the spectral radiances of the Earth and its atmosphere (measured at satellite altitude) and inverted that equation mathematically to infer the atmospheric temperature profile from satellite-based measurements of those radiances. A difficulty they had to overcome was that the mathematical problem is ill-posed, i.e., it admits of an infinite number of solutions. They arrived at a unique solution via an innovative application of a-priori information on the atmospheric state. This work was described in the landmark 1965 Wark and Fleming paper in the American Meteorological Society's Monthly Weather Review. From that early period until just weeks before his death, Dr. Wark continued

1. Historic American Buildings Survey E. H. Pickering, Photographer June ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey E. H. Pickering, Photographer June 1936 INSCRIPTION: JERUSALEM MILLS ESTABLISHED 1772 BY DAVID LEE, A QUAKER FROM BUCKS COUNTY PENNSYLVANIA. A GUN MANUFACTORY BACK OF THE MILL FURNISHED GUNS FOR THE REVOLUTION IN 1776, THE ORIGINAL TRACT CALLED JERUSALEM PARENTED 1687. - Jerusalem Grist Mill, Jerusalem Road vicinity, Little Gunpowder River, Jerusalem, Baltimore County, MD

David Stafford-Clark (1916-1999): Seeing through a celebrity psychiatrist.

PubMed

Miller, Gavin

2017-04-26

This article uses the mass-media career of the British psychiatrist David Stafford-Clark (1916-1999) as a case study in the exercise of cultural authority by celebrity medical professionals in post-war Britain. Stafford-Clark rose to prominence in the mass media, particularly through his presenting work on medical and related topics for BBC TV and Radio, and was in the vanguard of psychiatrists and physicians who eroded professional edicts on anonymity. At the height of his career, he traded upon his celebrity status, and consequent cultural authority, to deliver mass media sermons on a variety of social, cultural, and political topics. Stafford-Clark tried to preserve his sense of personal and intellectual integrity by clinging to a belief that his authority in the public sphere was ultimately to be vindicated by his literary, intellectual, and spiritual significance. But as his credibility dwindled, he came to distrust the cultural intermediaries, such as broadcasters and publishers, who had supported him.

David Price--Pioneer of digital ICP monitoring, neurosurgeon and teacher.

PubMed

Czosnyka, Marek; Kirollos, Ramez; van Hille, Philip

2015-06-01

In early 1970s first personal desk-top computers started to be available in hospitals. Mr Price was one of the pioneers introducing his own software to identify Marmarou's model of CSF space during infusion studies to diagnose patients suffering from hydrocephalus. His closed-loop control system for infusion of mannitol to manage patients at risk of intracranial hypertension was designed in 1977. The system worked successfully for 10 years in Pinderfields Hospital in Wakefield, UK. In the middle 1980's he initiated international cooperation with Children's Health Centre in Poland in long-term computer-assisted monitoring and analysis of ICP. Software designed in a course of this cooperation paved the way for contemporary package of ICM+ (Intensive Care Monitor, University of Cambridge, UK). Our scientific portfolio from these years (1985-1995) contains hundreds of head injured patients with waveform ICP analysis, introduction of compensatory reserve index RAP, few highly cited papers. Now, we understand ICP much better thanks to David's personal passion and extremely friendly support.

David Stafford-Clark (1916-1999): Seeing through a celebrity psychiatrist

PubMed Central

Miller, Gavin

2017-01-01

This article uses the mass-media career of the British psychiatrist David Stafford-Clark (1916-1999) as a case study in the exercise of cultural authority by celebrity medical professionals in post-war Britain. Stafford-Clark rose to prominence in the mass media, particularly through his presenting work on medical and related topics for BBC TV and Radio, and was in the vanguard of psychiatrists and physicians who eroded professional edicts on anonymity. At the height of his career, he traded upon his celebrity status, and consequent cultural authority, to deliver mass media sermons on a variety of social, cultural, and political topics. Stafford-Clark tried to preserve his sense of personal and intellectual integrity by clinging to a belief that his authority in the public sphere was ultimately to be vindicated by his literary, intellectual, and spiritual significance. But as his credibility dwindled, he came to distrust the cultural intermediaries, such as broadcasters and publishers, who had supported him. PMID:28503668

The influence of David Keeling on oceanic CO2 measurements

NASA Astrophysics Data System (ADS)

Brewer, Peter G.

Dave Keeling—only Roger Revelle called him "Charles David" and always in a tone that could command Dave's attention—had a remarkable influence on the creation of modern understanding of the oceanic CO2 system. Although Dave resided at an oceanographic institution for almost his entire professional career, the great majority of his work concerned atmospheric measurements; his own account of his work [Keeling, 1998] makes scant reference to his ocean science papers. But those relatively few oceanic papers, and more importantly his intense personal interest and unimpeachable reputation for classic measurement, had enormous impact. It is possible to trace Dave's influence on oceanic measurement through the course of five decades, and over that time, our understanding has grown enormously. The following is a somewhat personal account, but Dave so influenced the careers of the small group of ocean CO2 scientists that have led the way that any one of them would write a similar account.

9. Tempe Canal, Section 17 (TIN, R5E), looking east towards ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Tempe Canal, Section 17 (TIN, R5E), looking east towards the mesa. This is the oldest part of the canal still in use. Photographer: Mark Durben, June 1989. Source: SRPA - Tempe Canal, South Side Salt River in Tempe, Mesa & Phoenix, Tempe, Maricopa County, AZ

NASA astronaut and Mir 24 crew member David Wolf after landing

NASA Technical Reports Server (NTRS)

1998-01-01

NASA astronaut and Mir 24 crew member David Wolf, M.D., who was on the Russian Space Station Mir since late September 1997, greets his friend, Tammy Kruse, shortly after his return to Earth on Jan. 31. Dr. Wolf returned aboard the orbiter Endeavour with the rest of the STS-89 crew, including Commander Terrence Wilcutt; Pilot Joe Edwards Jr.; and Mission Specialists James Reilly, Ph.D.; Michael Anderson; Bonnie Dunbar, Ph.D.; and Salizhan Sharipov with the Russian Space Agency. STS-89 Mission Specialist Andrew Thomas, Ph.D., succeeded Dr. Wolf on Mir and is scheduled to remain on the Russian space station until the STS-91 Shuttle mission returns in June 1998. In addition to the docking and crew exchange, STS-89 included the transfer of science, logistical equipment and supplies between the two orbiting spacecrafts.

Mind-modelling with corpus stylistics in David Copperfield

PubMed Central

Mahlberg, Michaela

2015-01-01

We suggest an innovative approach to literary discourse by using corpus linguistic methods to address research questions from cognitive poetics. In this article, we focus on the way that readers engage in mind-modelling in the process of characterisation. The article sets out our cognitive poetic model of characterisation that emphasises the continuity between literary characterisation and real-life human relationships. The model also aims to deal with the modelling of the author’s mind in line with the modelling of the minds of fictional characters. Crucially, our approach to mind-modelling is text-driven. Therefore we are able to employ corpus linguistic techniques systematically to identify textual patterns that function as cues triggering character information. In this article, we explore our understanding of mind-modelling through the characterisation of Mr. Dick from David Copperfield by Charles Dickens. Using the CLiC tool (Corpus Linguistics in Cheshire) developed for the exploration of 19th-century fiction, we investigate the textual traces in non-quotations around this character, in order to draw out the techniques of characterisation other than speech presentation. We show that Mr. Dick is a thematically and authorially significant character in the novel, and we move towards a rigorous account of the reader’s modelling of authorial intention. PMID:29708113

Mind-modelling with corpus stylistics in David Copperfield.

PubMed

Stockwell, Peter; Mahlberg, Michaela

2015-05-01

We suggest an innovative approach to literary discourse by using corpus linguistic methods to address research questions from cognitive poetics. In this article, we focus on the way that readers engage in mind-modelling in the process of characterisation. The article sets out our cognitive poetic model of characterisation that emphasises the continuity between literary characterisation and real-life human relationships. The model also aims to deal with the modelling of the author's mind in line with the modelling of the minds of fictional characters. Crucially, our approach to mind-modelling is text-driven. Therefore we are able to employ corpus linguistic techniques systematically to identify textual patterns that function as cues triggering character information. In this article, we explore our understanding of mind-modelling through the characterisation of Mr. Dick from David Copperfield by Charles Dickens. Using the CLiC tool (Corpus Linguistics in Cheshire) developed for the exploration of 19th-century fiction, we investigate the textual traces in non-quotations around this character, in order to draw out the techniques of characterisation other than speech presentation. We show that Mr. Dick is a thematically and authorially significant character in the novel, and we move towards a rigorous account of the reader's modelling of authorial intention.

The Eclipse of the Public: A Response to David Elliott's "Music Education as/for Artistic Citizenship"

ERIC Educational Resources Information Center

Woodford, Paul

2014-01-01

This paper is an invited response to a one published by David Elliott in The Music Educator in 2012 in which music teachers were enjoined to encourage children to use music's expressive power as a political tool in pursuit of social justice. While in agreement with him that this can be an appropriate use of music, there is a curious avoidance…

Mrs. Hugh Dryden unveils the memorial to her late husband at center dedication, with center director David Scott

NASA Image and Video Library

1976-03-26

On March 26, 1976, the NASA Flight Research Center opened its doors to hundreds of guests for the dedication of the center in honor of Hugh Latimer Dryden. The dedication was very much a local event; following Center Director David Scott’s opening remarks, the Antelope Valley High School’s symphonic band played the national anthem. Invocation was given followed by recognition of the invited guests. Dr. Hugh Dryden, a man of total humility, received praise from all those present. Dryden, who died in 1965, had been a pioneering aeronautical scientist who became director of the National Advisory Committee for Aeronautics (NACA) in 1949 and then deputy administrator of the NACA’s successor, NASA, in 1958. Very much interested in flight research, he had been responsible for establishing a permanent facility at the location later named in his honor. As Center Director David Scott looks on, Mrs. Hugh L. Dryden (Mary Libbie Travers) unveils the memorial to her husband at the dedication ceremony.On March 26, 1976, the NASA Flight Research Center opened its doors to hundreds of guests for the dedication of the center in honor of Hugh Latimer Dryden.

A Philosophical Analysis of David Orr's Theory of Ecological Literacy: Biophilia, Ecojustice and Moral Education in School Learning Communities

ERIC Educational Resources Information Center

Mitchell, Debra B.; Mueller, Michael P.

2011-01-01

In his writings, David Orr claims that the US is in an "ecological crisis" and that this stems from a crisis of education. He outlines a theory of ecological literacy, a mode by which we better learn the ecology of the Earth and live in a sustainable manner. While emphasizing a shock doctrine, the diagnosis of "crisis" may be…

Astronaut David Scott watching hammer and feather fall to lunar surface

NASA Image and Video Library

1971-08-02

S71-43788 (2 Aug. 1971) --- Astronaut David R. Scott, Apollo 15 commander, watches a geological hammer and a feather hit the lunar surface simultaneously in a test of Galileo's law of motion concerning falling bodies, as seen in this color reproduction taken from a transmission made by the RCA color television camera mounted on the Lunar Roving Vehicle (LRV). Scott released the hammer from his right hand and the feather from his left at the same instant. Galileo (1564-1642) was the great Italian astronomer and physicist. This experiment occurred toward the end of the third and final lunar surface extravehicular activity (EVA) by astronauts Scott and James B. Irwin, lunar module pilot. While Scott and Irwin descended in the Lunar Module (LM) to explore the moon, astronaut Alfred M. Worden, command module pilot, remained in the Command and Service Modules (CSM) in lunar orbit.

Life Cycle Cost of C-130E Weapon System.

DTIC Science & Technology

1977-07-01

AFHRL-TR-7746 A-,I K lR FORCE g•r ___ FORCELIFE CYCLE COST OF C-130E WEAPON SYSTEM H By U Frank D. Brown "Gary A. WalkerU David H. WilsonBooing Awsp...I REPORT DOCUMENTO ON PAGE BEFORE COMPLETING FORM I?~ AFHR R.77-46 ( ~ LIFE CYCLE COST OF:C413A~ WEAPON SYSTEMteim.e M- 29 June 116- 3 June...human resources cost data life cycle cost historical weapon system analysis (I-WSA) inateuial resources 20). ABSTRACT (Con tinue on reverse siLa Mf

jsc2018e050022

NASA Image and Video Library

2018-05-21

jsc2018e050022 - At the Baikonur Museum in Baikonur, Kazakhstan, Expedition 56 backup crewmember David Saint-Jacques of the Canadian Space Agency signs a wall photo May 21 depicting the statue of Yuri Gagarin, the first human to fly in space, during traditional pre-launch activities. Saint-Jacques is one of the backups to the prime crewmembers, Serena Aunon-Chancellor of NASA, Sergey Prokopyev of Roscosmos and Alexander Gerst of the European Space Agency, who will launch June 6 on the Soyuz MS-09 spacecraft from Baikonur for a six-month mission on the International Space Station...NASA/Victor Zelentsov.

Spacecraft Charging Technology Conference (9th) Held in Tsukuba, Japan on 4-8 April 2005. Book of Abstracts

DTIC Science & Technology

2005-04-01

Electron Emission for Modeling Spacecraft Charging(025ole) Adrian Wheelock - AFRL/VSBX Simulations of Current Coupling in Ion Beam...Boxue Du - Tianjin University Discharge Characteristic of Gamma-Ray Irradiated Polybutylene Naphthalatem3-*u) Shana Figueroa - Air Force Research...FAX : (858)826-1653 E-mail : myron.j.mandell @saic.com David L. Cooke, Adrian Wheelock Air Force Research Laboratory, Space Vehicles

Mathematical Foundations of Programming Semantics International Conference (9th) Held in New Orleans, Louisiana, April 1993

DTIC Science & Technology

1993-04-01

Informatica 23, pp. 9 - 66 [10] Petri, C.A., Kommunikation mit Automaten, Institut fiir Instrumentelle Mathematik, Schriften des IIM, Nr. 2, Bonn 1962...Flow 122 J. W. de Bakker and Franck van Breugel An Investigation into Functions as Processes 143 Davide Sangiorgi Time Abstracted Bisimulation: Implicit...Jagadeesan: By De Morgan laws, finding a winning strategy in AOB-oA amounts to find a winning strategy in (A-oA)V’B± (where V is the dual of ®). Let A be an

Solution structure of the C-terminal domain of Ole e 9, a major allergen of olive pollen

PubMed Central

Treviño, Miguel Á.; Palomares, Oscar; Castrillo, Inés; Villalba, Mayte; Rodríguez, Rosalía; Rico, Manuel; Santoro, Jorge; Bruix, Marta

2008-01-01

Ole e 9 is an olive pollen allergen belonging to group 2 of pathogenesis-related proteins. The protein is composed of two immunological independent domains: an N-terminal domain (NtD) with 1,3-β-glucanase activity, and a C-terminal domain (CtD) that binds 1,3-β-glucans. We have determined the three-dimensional structure of CtD-Ole e 9 (101 amino acids), which consists of two parallel α-helices forming an angle of ∼55°, a small antiparallel β-sheet with two short strands, and a 3–10 helix turn, all connected by long coil segments, resembling a novel type of folding among allergens. Two regions surrounded by aromatic residues (F49, Y60, F96, Y91 and Y31, H68, Y65, F78) have been localized on the protein surface, and a role for sugar binding is suggested. The epitope mapping of CtD-Ole e 9 shows that B-cell epitopes are mainly located on loops, although some of them are contained in secondary structural elements. Interestingly, the IgG and IgE epitopes are contiguous or overlapped, rather than coincident. The three-dimensional structure of CtD-Ole e 9 might help to understand the underlying mechanism of its biochemical function and to determine possible structure–allergenicity relationships. PMID:18096638

International Conference on Artificial Immune Systems (1st) ICARIS 2002, held on 9, 10, and 11 September 2002

DTIC Science & Technology

2002-03-07

Michalewicz, Eds., Evolutionary Computation 1: Basic Algorithms and Operators, Institute of Physics, Bristol (UK), 2000. [3] David A. Van Veldhuizen ...2000. [4] Carlos A. Coello Coello, David A. Van Veldhuizen , and Gary B. Lamont, Evolutionary Algorithms for Solving Multi-Objective Problems, Kluwer...Academic Publishers, 233 Spring St., New York, NY 10013, 2002. [5] David A. Van Veldhuizen , Multiobjective Evolution- ary Algorithms: Classifications

Reconstructing apology: David Cameron's Bloody Sunday apology in the press.

PubMed

McNeill, Andrew; Lyons, Evanthia; Pehrson, Samuel

2014-12-01

While there is an acknowledgement in apology research that political apologies are highly mediated, the process of mediation itself has lacked scrutiny. This article suggests that the idea of reconstruction helps to understand how apologies are mediated and evaluated. David Cameron's apology for Bloody Sunday is examined to see how he constructs four aspects of apology: social actors, consequences, categorization, and reasons. The reconstruction of those aspects by British, Unionist, and Nationalist press along with reconstructions made by soldiers in an online forum are considered. Data analysis was informed by thematic analysis and discourse analysis which helped to explore key aspects of reconstruction and how elements of Cameron's apology are altered in subsequent mediated forms of the apology. These mediated reconstructions of the apology allowed their authors to evaluate the apology in different ways. Thus, in this article, it is suggested that the evaluation of the apology by different groups is preceded by a reconstruction of it in accordance with rhetorical goals. This illuminates the process of mediation and helps to understand divergent responses to political apologies. © 2013 The British Psychological Society.

Professor Samuel David Gross (1805-1884) and His Innovations in Surgery and Medicine.

PubMed

Laios, Konstantinos

2018-06-01

Professor Samuel David Gross (1805-1884) is considered as one of the founders of American surgery. He was a skillful surgeon who could excellently perform a lithotomy, an amputation, and a cataract surgery. He introduced many new surgical techniques and designed new surgical and medical instruments. He expertise was not limited to surgery alone; he also published studies concerning internal medicine, pathology, experimental physiology, and pharmacology. His most important treatise was his 2-volume work, A System of Surgery, Pathological, Diagnostic, Therapeutic and Operative (1861), which was a standard reference book in surgery in the United States during the second half of 19th century. Gross received many honors during his life. He was active in the operating room until his death.

Activation of Adiponectin Receptor Regulates Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Inhibits Lesions in ApoE-Deficient Mice.

PubMed

Sun, Lei; Yang, Xiaoxiao; Li, Qi; Zeng, Peng; Liu, Ying; Liu, Lipei; Chen, Yuanli; Yu, Miao; Ma, Chuanrui; Li, Xiaoju; Li, Yan; Zhang, Rongxin; Zhu, Yan; Miao, Qing Robert; Han, Jihong; Duan, Yajun

2017-07-01

The reduced adiponectin levels are associated with atherosclerosis. Adiponectin exerts its functions by activating adiponectin receptor (AdipoR). Proprotein convertase subtilisin kexin type 9 (PCSK9) degrades LDLR protein (low-density lipoprotein receptor) to increase serum LDL-cholesterol levels. PCSK9 expression can be regulated by PPARγ (peroxisome proliferator-activated receptor γ) or SREBP2 (sterol regulatory element-binding protein 2). The effects of AdipoR agonists on PCSK9 and LDLR expression, serum lipid profiles, and atherosclerosis remain unknown. At cellular levels, AdipoR agonists (ADP355 and AdipoRon) induced PCSK9 transcription/expression that solely depended on activation of PPAR-responsive element in the PCSK9 promoter. AdipoR agonists induced PPARγ expression; thus, the AdipoR agonist-activated PCSK9 expression/production was impaired in PPARγ deficient hepatocytes. Meanwhile, AdipoR agonists transcriptionally activated LDLR expression by activating SRE in the LDLR promoter. Moreover, AMP-activated protein kinase α (AMPKα) was involved in AdipoR agonist-activated PCSK9 expression. In wild-type mice, ADP355 increased PCSK9 and LDLR expression and serum PCSK9 levels, which was associated with activation of PPARγ, AMPKα and SREBP2 and reduction of LDL-cholesterol levels. In contrast, ADP355 reduced PCSK9 expression/secretion in apoE-deficient (apoE -/- ) mice, but it still activated hepatic LDLR, PPARγ, AMPKα, and SREBP2. More importantly, ADP355 inhibited lesions in en face aortas and sinus lesions in aortic root in apoE -/- mice with amelioration of lipid profiles. Our study demonstrates that AdipoR activation by agonists regulated PCSK9 expression differently in wild-type and apoE -/- mice. However, ADP355 activated hepatic LDLR expression and ameliorated lipid metabolism in both types of mice and inhibited atherosclerosis in apoE -/- mice. © 2017 American Heart Association, Inc.

"In the Hands of the Receivers": The Politics of Literacy in "The Savage" by David Almond and Dave McKean

ERIC Educational Resources Information Center

Hateley, Erica

2012-01-01

David Almond and Dave McKean's "The Savage" is a hybrid prose and graphic novel which tells the story of one young man's maturation through literacy. The protagonist learns to deal with the death of his father and his own "savage" self by writing a graphic novel. This article reads "The Savage" in the context of earlier, "Northern" literacy…

Power Play: The Dynamics of Power and Interpersonal Communication in Higher Education as Reflected in David Mamet's "Oleanna"

ERIC Educational Resources Information Center

Chiaramonte, Peter

2014-01-01

David Mamet's play "Oleanna" may be infamous for reasons that do not do justice to the play's real accomplishments. One reason for the controversy is the author's apparent focus on sexual harassment. The play is not about sexual harassment. It is about power. And in particular the power of language to shape relationships…

The moral status of the embryo: an attempt at an analysis with the aid of David Hume's ethics.

PubMed

Engel, J B; Hönig, A; Segerer, S; Häusler, S F M; Dietl, J; Djakovic, A

2010-12-01

This article applies the moral sentimentalism founded by David Hume to the moral status of the embryo. It will attempt to explain the paradoxical fact that in Germany abortion is common and socially accepted while preimplantation genetic diagnosis is banned with the aid of an approach based on moral sentimentalism. David Hume established the thesis that the human being is guided by the emotions and not by reason when making moral decisions. Scientific innovations often create a feeling of anxiety. Consequently, the initial moral judgment about it is negative. Due to this habit, the innovation is often accepted after a phase of indifference. This phenomenon has been observed in the case of heart transplantation, as well as for IVF. Consequently, the apparent contradiction in the varying degrees of the embryo's worthiness of protection in the womb and in the Petri dish is due to the simple fact that these are different stages of habituation. Therefore, the ethics of Hume cannot stipulate the embryo's moral status for once and for all; however, they can paradoxically raise the ongoing current debate to a more rational level through the insight that the underlying moral concepts are not based on reason alone. Copyright © 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

David Miller | NREL

Science.gov Websites

Publications D.C. Miller, E. Annigoni, A. Ballion, J.G. Bokria, L.S. Bruckman, D.M. Burns, X. Chen, L. Elliott , J. Feng, R.H. French, S. Fowler, C.C. Honeker, M.D. Kempe, H. Khonkar, M. Köhl, L.-E. Perret-Aebi , L. Elliott, L. Feng, R.H. French, S. Fowler, X. Gu, P.L. Hacke, C.C. Honeker, M.D. Kempe, H. Khonkar

The Integration of Jesus' Great Commandment within Christian Higher Education: An Analysis of the Leadership Praxis of Dr. David S. Dockery

ERIC Educational Resources Information Center

Hickman, Tanner Franklin

2010-01-01

The purpose of this study was to better understand the leadership philosophy and key strategic actions of Dr. David S. Dockery in relation to Jesus' Great Commandment. Dockery's leadership has been instrumental in shaping and defining the meaning of Christian education during his fourteen year tenure as president of Union University. During his…

jsc2018e050016

NASA Image and Video Library

2018-05-21

jsc2018e050016 - In the town of Baikonur, Kazakhstan, Expedition 56 backup crewmember David Saint-Jacques of the Canadian Space Agency lays flowers at the statue of Yuri Gagarin, the first human to fly in space as his crewmates look on during traditional pre-launch activities May 21. Saint-Jacques, Anne McClain of NASA and Oleg Kononenko of Roscosmos are the backups to the prime crew, Serena Aunon-Chancellor of NASA, Sergey Prokopyev of Roscosmos and Alexander Gerst of the European Space Agency, who will launch June 6 on the Soyuz MS-09 spacecraft from Baikonur for a six-month mission on the International Space Station...NASA/Victor Zelentsov.

jsc2018e050018

NASA Image and Video Library

2018-05-21

jsc2018e0500108 - In the town of Baikonur, Kazakhstan, Expedition 56 backup crewmembers Anne McClain of NASA (left), Oleg Kononenko of Roscosmos (center) and David Saint-Jacques of the Canadian Space Agency (right), lay flowers and pay tribute at the statue of Sergei Korolev, the Russian space designer icon May 21 during traditional pre-launch activities. They are the backups to the prime crew, Serena Aunon-Chancellor of NASA, Sergey Prokopyev of Roscosmos and Alexander Gerst of the European Space Agency, who will launch June 6 on the Soyuz MS-09 spacecraft from Baikonur for a six-month mission on the International Space Station...NASA/Victor Zelentsov.

jsc2018e050017

NASA Image and Video Library

2018-05-21

jsc2018e050017 - In the town of Baikonur, Kazakhstan, Expedition 56 backup crewmembers David Saint-Jacques of the Canadian Space Agency (left), Oleg Kononenko of Roscosmos (center) and Anne McClain of NASA (right) pose for pictures May 21 at the statue of Yuri Gagarin, the first human to fly in space during traditional pre-launch activities. They are the backups to the prime crew, Serena Aunon-Chancellor of NASA, Sergey Prokopyev of Roscosmos and Alexander Gerst of the European Space Agency, who will launch June 6 on the Soyuz MS-09 spacecraft from Baikonur for a six-month mission on the International Space Station...NASA/Victor Zelentsov.

"Neither Can They Die Any More; for They Are Equal Unto the Angels": Secular Epiphanies in David Almond's "Counting Stars"

ERIC Educational Resources Information Center

Grace, Deborah

2014-01-01

Written before the successful publication of Skellig (1998), David Almond's short story collection, "Counting Stars," has attracted less critical attention than his more famous novels. Falling between fiction and autobiography, the earlier short stories are more firmly grounded in realism than the novels, which feature elements of…

A Novel HURRAH Protocol Reveals High Numbers of Monomorphic MHC Class II Loci and Two Asymmetric Multi-Locus Haplotypes in the Père David's Deer

PubMed Central

Wan, Qiu-Hong; Zhang, Pei; Ni, Xiao-Wei; Wu, Hai-Long; Chen, Yi-Yan; Kuang, Ye-Ye; Ge, Yun-Fa; Fang, Sheng-Guo

2011-01-01

The Père David's deer is a highly inbred, but recovered, species, making it interesting to consider their adaptive molecular evolution from an immunological perspective. Prior to this study, genomic sequencing was the only method for isolating all functional MHC genes within a certain species. Here, we report a novel protocol for isolating MHC class II loci from a species, and its use to investigate the adaptive evolution of this endangered deer at the level of multi-locus haplotypes. This protocol was designated “HURRAH” based on its various steps and used to estimate the total number of MHC class II loci. We confirmed the validity of this novel protocol in the giant panda and then used it to examine the Père David's deer. Our results revealed that the Père David's deer possesses nine MHC class II loci and therefore has more functional MHC class II loci than the eight genome-sequenced mammals for which full MHC data are currently available. This could potentially account at least in part for the strong survival ability of this species in the face of severe bottlenecking. The results from the HURRAH protocol also revealed that: (1) All of the identified MHC class II loci were monomorphic at their antigen-binding regions, although DRA was dimorphic at its cytoplasmic tail; and (2) these genes constituted two asymmetric functional MHC class II multi-locus haplotypes: DRA1*01 ∼ DRB1 ∼ DRB3 ∼ DQA1 ∼ DQB2 (H1) and DRA1*02 ∼ DRB2 ∼ DRB4 ∼ DQA2 ∼ DQB1 (H2). The latter finding indicates that the current members of the deer species have lost the powerful ancestral MHC class II haplotypes of nine or more loci, and have instead fixed two relatively weak haplotypes containing five genes. As a result, the Père David's deer are currently at risk for increased susceptibility to infectious pathogens. PMID:21267075

Functional visualization and disruption of targeted genes using CRISPR/Cas9-mediated eGFP reporter integration in zebrafish.

PubMed

Ota, Satoshi; Taimatsu, Kiyohito; Yanagi, Kanoko; Namiki, Tomohiro; Ohga, Rie; Higashijima, Shin-Ichi; Kawahara, Atsuo

2016-10-11

The CRISPR/Cas9 complex, which is composed of a guide RNA (gRNA) and the Cas9 nuclease, is useful for carrying out genome modifications in various organisms. Recently, the CRISPR/Cas9-mediated locus-specific integration of a reporter, which contains the Mbait sequence targeted using Mbait-gRNA, the hsp70 promoter and the eGFP gene, has allowed the visualization of the target gene expression. However, it has not been ascertained whether the reporter integrations at both targeted alleles cause loss-of-function phenotypes in zebrafish. In this study, we have inserted the Mbait-hs-eGFP reporter into the pax2a gene because the disruption of pax2a causes the loss of the midbrain-hindbrain boundary (MHB) in zebrafish. In the heterozygous Tg[pax2a-hs:eGFP] embryos, MHB formed normally and the eGFP expression recapitulated the endogenous pax2a expression, including the MHB. We observed the loss of the MHB in homozygous Tg[pax2a-hs:eGFP] embryos. Furthermore, we succeeded in integrating the Mbait-hs-eGFP reporter into an uncharacterized gene epdr1. The eGFP expression in heterozygous Tg[epdr1-hs:eGFP] embryos overlapped the epdr1 expression, whereas the distribution of eGFP-positive cells was disorganized in the MHB of homozygous Tg[epdr1-hs:eGFP] embryos. We propose that the locus-specific integration of the Mbait-hs-eGFP reporter is a powerful method to investigate both gene expression profiles and loss-of-function phenotypes.

Functional visualization and disruption of targeted genes using CRISPR/Cas9-mediated eGFP reporter integration in zebrafish

PubMed Central

Ota, Satoshi; Taimatsu, Kiyohito; Yanagi, Kanoko; Namiki, Tomohiro; Ohga, Rie; Higashijima, Shin-ichi; Kawahara, Atsuo

2016-01-01

The CRISPR/Cas9 complex, which is composed of a guide RNA (gRNA) and the Cas9 nuclease, is useful for carrying out genome modifications in various organisms. Recently, the CRISPR/Cas9-mediated locus-specific integration of a reporter, which contains the Mbait sequence targeted using Mbait-gRNA, the hsp70 promoter and the eGFP gene, has allowed the visualization of the target gene expression. However, it has not been ascertained whether the reporter integrations at both targeted alleles cause loss-of-function phenotypes in zebrafish. In this study, we have inserted the Mbait-hs-eGFP reporter into the pax2a gene because the disruption of pax2a causes the loss of the midbrain-hindbrain boundary (MHB) in zebrafish. In the heterozygous Tg[pax2a-hs:eGFP] embryos, MHB formed normally and the eGFP expression recapitulated the endogenous pax2a expression, including the MHB. We observed the loss of the MHB in homozygous Tg[pax2a-hs:eGFP] embryos. Furthermore, we succeeded in integrating the Mbait-hs-eGFP reporter into an uncharacterized gene epdr1. The eGFP expression in heterozygous Tg[epdr1-hs:eGFP] embryos overlapped the epdr1 expression, whereas the distribution of eGFP-positive cells was disorganized in the MHB of homozygous Tg[epdr1-hs:eGFP] embryos. We propose that the locus-specific integration of the Mbait-hs-eGFP reporter is a powerful method to investigate both gene expression profiles and loss-of-function phenotypes. PMID:27725766

SGR9, a RING type E3 ligase, modulates amyloplast dynamics important for gravity sensing.

NASA Astrophysics Data System (ADS)

Morita, Miyo T.; Nakamura, Moritaka; Tasaka, Masao

Gravitropism is triggered when the directional change of gravity is sensed in the specific cells, called statocytes. In higher plants, statocytes contain sinking heavier amyloplasts which are particular plastids accumulating starch granules. The displacement of amyloplasts within the statocytes is thought to be the initial event of gravity perception. We have demonstrated that endodermal cells are most likely to be the statocytes in Arabidop-sis shoots. Live cell imaging of the endodermal cell of stem has shown that most amyloplasts are sediment to the direction of gravity but they are not static. Several amyloplasts move dynamically in an actin filament (F-actin) dependent manner. In the presence of actin poly-merization inhibitor, all amyloplasts become static and sediment to the direction of gravity. In addition, stems treated with the inhibitor can exhibit gravitropism. These results suggest that F-actin-dependent dynamic movement of amyloplasts is not essential for gravity sensing. sgr (shoot gravitropism) 9 mutant exhibits greatly reduced shoot gravitropism. In endodermal cells of sgr9, dynamic amyloplast movement was predominantly observed and amyloplasts did not sediment to the direction of gravity. Interestingly, inhibition of actin polymerization re-stored both gravitropism and amyloplast sedimentation in sgr9. The SGR9 encodes a novel RING finger protein, which is localized to amyloplasts in endodermal cells. SGR9 showed ubiq-uitin E3 ligase activity in vitro. Together with live cell imaging of amyloplasts and F-actin, our data suggest that SGR9 modulate interaction between amyloplasts and F-actin on amylo-plasts. SGR9 positively act on amyloplasts sedimentation, probably by releasing amyloplasts from F-actin. SGR9 that is localized to amyloplast, possibly degrades unknown substrates by its E3 ligase activity, and this might promote release of amyloplasts from F-actin.

[Book review] Role of the wolf in a deer decline in the Superior National Forest, by L. David Mech and Patrick D. Karns

USGS Publications Warehouse

Greenwood, R.J.

1979-01-01

Review of: Role of the Wolf in a Deer Decline in the Superior National Forest. Volume 148 of USDA Forest Service Research Paper. L. David Mech and Patrick D. Karns. North Central Forest Experiment Station, Forest Service, United States Department of Agriculture, 1977. 23 pages.

IL-9-producing cells in the development of IgE-mediated food allergy.

PubMed

Shik, Dana; Tomar, Sunil; Lee, Jee-Boong; Chen, Chun-Yu; Smith, Andrew; Wang, Yui-Hsi

2017-01-01

Food allergy is a harmful immune reaction driven by uncontrolled type 2 immune responses. Considerable evidence demonstrates the key roles of mast cells, IgE, and TH2 cytokines in mediating food allergy. However, this evidence provides limited insight into why only some, rather than all, food allergic individuals are prone to develop life-threatening anaphylaxis. Clinical observations suggest that patients sensitized to food through the skin early in life may later develop severe food allergies. Aberrant epidermal thymic stromal lymphopoietin and interleukin (IL) 33 production and genetic predisposition can initiate an allergic immune response mediated by dendritic cells and CD4 + TH2 cells in inflamed skin. After allergic sensitization, intestinal IL-25 and food ingestion enhance concerted interactions between type 2 innate lymphoid cells (ILC2s) and CD4 + TH2 cells, which perpetuate allergic reactions from the skin to the gut. IL-4 and cross-linking of antigen/IgE/FcεR complexes induce emigrated mast cell progenitors to develop into the multi-functional IL-9-producing mucosal mast cells, which produce prodigious amounts of IL-9 and mast cell mediators to drive intestinal mastocytosis in an autocrine loop. ILC2s and TH9 cells may also serve as alternative cellular sources of IL-9 to augment the amplification of intestinal mastocytosis, which is the key cellular checkpoint in developing systemic anaphylaxis. These findings provide a plausible view of how food allergy develops and progresses in a stepwise manner and that atopic signals, dietary allergen ingestion, and inflammatory cues are fundamental in promoting life-threatening anaphylaxis. This information will aid in improving diagnosis and developing more effective therapies for food allergy-triggered anaphylaxis.

The ERIC Guidebook to the Background Papers for "A Call for Change in Teacher Education: The Report of the National Committee on Excellence in Teacher Education."

ERIC Educational Resources Information Center

ERIC Clearinghouse on Teacher Education, Washington, DC.

This guidebook contains abstracts of papers by the following authors: (1) Michael D. Andrew; (2) Herman E. Behling, Jr.; (3) Ken Carlson; (4) Frederic R. Cyphert and John E. Nichelson; (5) Barbara Dubitsky; (6) David H. Florio; (7) Eva C. Galambos; (8) Hendrik D. Gideonse; (9) Gary A. Griffin; (10) Martin Haberman; (11) Gene Hall, Walter Doyle,…

The wonder of their voices: The 1946 Holocaust interviews of David Boder (New York: Oxford, 2010).

PubMed

Rosen, Alan C

2012-05-01

Writing a study of psychologist David Boder's 1946 displaced persons (DP) interview project gave me a chance to further document the substantial early response to the Holocaust. This was clearly one important piece of my study, and one that was eminently straightforward. Yet much of the research on Boder's project at the point in time that I carried it out was elliptical, partly because the primary interview materials were coming to light at an astonishing pace, partly because the archive collections were virtually untapped, and partly because of the misconception of Boder and his interview project itself.

Spotlight: David Wood, MD, MSc, FRCP, FESC. A journey from a remote area of Scotland to the capital of the United Kingdom. Interview by Hannah Brown.

PubMed

Wood, David

2007-12-04

The death of an ambulance driver prompted David Wood, MD, MSc, FRCP, FESC, now Garfield Weston Professor of Cardiovascular Medicine at Imperial College, London, United Kingdom, to pursue cardiology as a career.

One-stage hybrid surgery for acute Stanford type A aortic dissection with David operation, aortic arch debranching, and endovascular graft: a case report.

PubMed

Liu, Lulu; Qin, Chaoyi; Hou, Jianglong; Zhu, Da; Zhang, Bengui; Ma, Hao; Guo, Yingqiang

2016-12-01

Acute Stanford type A aortic dissection requires an extremely complex surgical strategy and presents high risk of complications. Although many different procedures were reported to treat this aortic dissection, high mortality rate and incidences of complications still exist. This study presents a 59-year-old lady with acute Stanford type A aortic dissection, which originated from the aortic root to proximal part of right external iliac artery and involved the brachiocephalic trunk, left carotid artery, celiac trunk, and left renal artery. The patient underwent one-stage hybrid surgery of David procedures, debranching, and endovascular aortic repair under ultrasound-guided aortic arch cannulation cardiopulmonary bypass (CPB). The surgery was successfully performed, and the patient showed no post-operative complication. The one-staged hybrid surgery of David procedures, debranching, and endovascular aortic repair provides novel and well-designed combined techniques for treating complex acute Stanford type A aortic dissection. Our techniques significantly lowered the risks, thereby expanding the indications of surgical intervention for acute Stanford type A aortic dissection.

The reconstitution of political theory: David Easton, behavioralism, and the long road to system.

PubMed

Gunnell, John G

2013-01-01

During the last half of the twentieth century, the concept of system was arguably the most important concept in the theoretical repertoire of the discipline of American political science. Although systems analysis was broadly employed in the behavioral sciences, David Easton's work was particularly influential in the study of politics. This is in part because he attempted to develop a distinct account of the political system that was not theoretically subservient either to general systems theory or to conceptions of the social system such as that advanced by Talcott Parsons. Although a great deal of attention has been devoted to Easton's theory, the origins and evolution of the system concept in his work have not been carefully reconstructed and analyzed. © 2013 Wiley Periodicals, Inc.

Fluorescence lifetime imaging and Fourier transform infrared spectroscopy of Michelangelo's David.

PubMed

Comelli, Daniela; Valentini, Gianluca; Cubeddu, Rinaldo; Toniolo, Lucia

2005-09-01

We developed a combined procedure for the analysis of works of art based on a portable system for fluorescence imaging integrated with analytical measurements on microsamples. The method allows us to localize and identify organic and inorganic compounds present on the surface of artworks. The fluorescence apparatus measures the temporal and spectral features of the fluorescence emission, excited by ultraviolet (UV) laser pulses. The kinetic of the emission is studied through a fluorescence lifetime imaging system, while an optical multichannel analyzer measures the fluorescence spectra of selected points. The chemical characterization of the compounds present on the artistic surfaces is then performed by means of analytical measurements on microsamples collected with the assistance of the fluorescence maps. The previous concepts have been successfully applied to study the contaminants on the surface of Michelangelo's David. The fluorescence analysis combined with Fourier transform infrared (FT-IR) measurements revealed the presence of beeswax, which permeates most of the statue surface, and calcium oxalate deposits mainly arranged in vertical patterns and related to rain washing.

In Response to David Greenwood's "Place Mobility and Faculty Life: Mindfulness through Change" through the Lens of Science Teacher Education Programs

ERIC Educational Resources Information Center

Nyaema, Mary K.

2017-01-01

In writing this review, I draw on the experience of David Greenwood ("Cult Stud Sci Educ" 10:5-16, 2015) whose ethnographic study sheds light on his growth as a faculty member who has taught in various settings that are quite different from the culture that he grew up with. I extend his thoughts on ecological mindfulness to encompass a…

Modeling and 3D Visualization for Evaluation of Anti-Terrorism/Force Protection Alternatives: Phase II Final Report

DTIC Science & Technology

2006-11-21

SCHOOL Monterey, California 93943-5000 COL David A. Smarsh, USAF Dr. Leonard A. Ferrari Acting President...1.3.6 Planet 9 Studios David Colleen, CEO Chris Greuel, 3D Model Engineer Dan Ancona, Documentation and Training Carlos Newcomb, 3D Imagery...informational forum of M&S professionals working in the service of naval installation security. David Colleen, CEO, Planet 9 Studios, gave a

Depletion of elongation initiation factor 4E binding proteins by CRISPR/Cas9 enhances the antiviral response in porcine cells.

PubMed

Ramírez-Carvajal, Lisbeth; Singh, Neetu; de los Santos, Teresa; Rodríguez, Luis L; Long, Charles R

2016-01-01

Type I interferons (IFNs) are key mediators of the innate antiviral response in mammalian cells. Elongation initiation factor 4E binding proteins (4E-BPs) are translational controllers of interferon regulatory factor 7 (IRF-7), the "master regulator" of IFN transcription. Previous studies have suggested that mouse cells depleted of 4E-BPs are more sensitive to IFNβ treatment and had lower viral loads as compared to wild type (WT) cells. However, such approach has not been tested as an antiviral strategy in livestock species. In this study, we tested the antiviral activity of porcine cells depleted of 4E-BP1 by a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein-9 nuclease (Cas9) genome engineering system. We found that 4E-BP1 knockout (KO) porcine cells had increased expression of IFNα and β, IFN stimulated genes, and significant reduction in vesicular stomatitis virus titer as compare to WT cells. No phenotypical changes associated with CRISPR/Cas9 manipulation were observed in 4E-BP1 KO cells. This work highlights the use of the CRISPR/Cas9 system to enhance the antiviral response in porcine cells. Copyright © 2015 Elsevier B.V. All rights reserved.

David N. Reznick's The " Origin" Then and Now: An Interpretive Guide to the " Origin of Species": A Précis

NASA Astrophysics Data System (ADS)

Ruse, Michael

2013-09-01

David Reznick is one of the world's leading evolutionary biologists. His book on Charles Darwin's Origin of Species is given here in a précis, in order to show the underlying approach that he takes towards a work that is a classic in his field. It is shown that Reznick's interests are less in Darwin for his own sake and more in the importance of Darwin's ideas for science today.

Study of the decays D0-->pi{-}e{+}nu{e}, D{0}-->K{-}e{+}nu{e}, D{+}-->pi{0}e{+}nu{e}, and D{+}-->K0e{+}nu{e}.

PubMed

Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Ernst, J; Severini, H; Dytman, S A; Love, W; Savinov, V; Aquines, O; Li, Z; Lopez, A; Mehrabyan, S; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Coan, T E; Gao, Y S; Liu, F; Artuso, M; Blusk, S; Butt, J; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Briere, R A; Brock, I; Chen, J; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Weinberger, M; Athar, S B; Patel, R; Potlia, V; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; White, E J; Wiss, J; Shepherd, M R; Besson, D; Pedlar, T K

2008-06-27

By using 1.8x10{6} DDpairs, we have measured B(D{0}-->pi{-}e{+}nu{e})=0.299(11)(9)%, B(D{+}-->pi{0}e{+}nu{e})=0.373(22)(13)%, B(D{0}-->K{-}e{+}nu{e})=3.56(3)(9)%, and B(D{+}-->K{0}e{+}nu{e})=8.53(13)(23)% and have studied the q;{2} dependence of the form factors. By combining our results with recent lattice calculations, we obtain |V{cd}|=0.217(9)(4)(23) and |V{cs}|=1.015(10)(11)(106).

ePESSTO spectroscopic classification of the candidate TDE XMMSL2 J140446.9-251135

NASA Astrophysics Data System (ADS)

Taubenberger, S.; Floers, A.; Vogl, C.; Benetti, S.; Pastorello, A.; Cappellaro, E.; Anderson, J.; Gromadzki, M.; Onori, F.; Kostrzewa-Rutkowska, Z.; Jonker, P.; Leloudas, G.; Inserra, C.; Kankare, E.; Maguire, K.; Smartt, S. J.; Yaron, O.; Young, D.

2018-03-01

ePESSTO, the extended Public ESO Spectroscopic Survey for Transient Objects (see Smartt et al. 2015, A & A, 579, 40; http://www.pessto.org ), reports the following spectroscopic observation of the new X-ray source XMMSL2 J140446.9-251135 in the galaxy 2MASX 14044671-2511433 (ATel #11394).

26 CFR 1.514(c)-2 - Permitted allocations under section 514(c)(9)(E).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Permitted allocations under section 514(c)(9)(E). 1.514(c)-2 Section 1.514(c)-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Taxation of Business Income of Certain Exempt...

Incidence of Testicular Cancer in U.S. Air Force Officer Aviators: 1998-2008

DTIC Science & Technology

2011-06-01

DAVID B. RHODES, Col, USAF, MC ROBERT E. CARROLL , Col, USAF, MC, CFS This... S ) Christopher Walker 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) USAF...REPORT NUMBER AFRL-SA-WP-SR-2012-0001 9. SPONSORING / MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSORING/MONITOR’S ACRONYM( S

Emotional intelligence as an aspect of general intelligence: what would David Wechsler say?

PubMed

Kaufman, A S; Kaufman, J C

2001-09-01

R. D. Roberts, M. Zeidner, and G. Matthews (2001) have carefully examined the controversial issue of whether emotional intelligence (EI) should be classified as an intelligence and whether EI's constructs meet the same psychometric standards as general intelligence's constructs. This article casts their efforts into the framework of both historical and modern IQ-testing theory and research. It details David Wechsler's attempts to integrate EI into his tests and how his conception of a good clinician would be that of an emotionally intelligent clinician. Current theories and research on IQ also have a role in EI beyond what Roberts et al. described, including J. L. Horn's (1989) expanded model and A. R. Luria's (1966) neuropsychological research, and better criteria than the Armed Services Vocational Aptitude Battery should be used in future EI studies. The authors look forward to more research being conducted on EI, particularly in future performance-based assessments.

Bridging Divides--Social Science, Educational Policy and the Improvement of Education and Training Systems: An Appreciation the Contribution of David Raffe (1950-2015)

ERIC Educational Resources Information Center

Howieson, Cathy; Spours, Ken; Young, Michael

2017-01-01

This Introduction provides an overview of the distinctive contribution of the late David Raffe to educational research in the UK and internationally over a 40-year period. His wide-ranging research on post-compulsory education and training systems was enriched by the development of conceptual distinctions that have become part of the lingua franca…

One-stage hybrid surgery for acute Stanford type A aortic dissection with David operation, aortic arch debranching, and endovascular graft: a case report

PubMed Central

Liu, Lulu; Qin, Chaoyi; Hou, Jianglong; Zhu, Da; Zhang, Bengui; Ma, Hao

2016-01-01

Acute Stanford type A aortic dissection requires an extremely complex surgical strategy and presents high risk of complications. Although many different procedures were reported to treat this aortic dissection, high mortality rate and incidences of complications still exist. This study presents a 59-year-old lady with acute Stanford type A aortic dissection, which originated from the aortic root to proximal part of right external iliac artery and involved the brachiocephalic trunk, left carotid artery, celiac trunk, and left renal artery. The patient underwent one-stage hybrid surgery of David procedures, debranching, and endovascular aortic repair under ultrasound-guided aortic arch cannulation cardiopulmonary bypass (CPB). The surgery was successfully performed, and the patient showed no post-operative complication. The one-staged hybrid surgery of David procedures, debranching, and endovascular aortic repair provides novel and well-designed combined techniques for treating complex acute Stanford type A aortic dissection. Our techniques significantly lowered the risks, thereby expanding the indications of surgical intervention for acute Stanford type A aortic dissection. PMID:28149590

Characterization of Electrical Properties of Polymers for Conductive Nano-Composites

DTIC Science & Technology

2011-05-01

Research Triangle Park, NC 27709-2211 15. SUBJECT TERMS Nano composites, piezo -resistivity, quantum tunneling Oliver K. Johnson, Daniel Seegmiller, David T...plate component of the circuit (i.e. ) with known resistors from 1Ω to 2×10 9 Ω and recording the corresponding output voltage. Using this

A Guide for Measuring, Analyzing, and Evaluating Accelerations Recorded During Seakeeping Trials of High-Speed Craft

DTIC Science & Technology

2016-01-01

Smith, Strether. Digital Data Acquisition and Analysis, A short course presented at Sensors Expo Chicago , June 9, 2008. 11. Judd, Bob, Everything You...Forces, CG 731 2100 Second Street, SW STOP 356 Washington, DC 20593-7356 Attn: David Shepard United States Coast Guard RDT&E Division 2100 Second

Locomotor activity, emotionality, sensori-motor gating, learning and memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease.

PubMed

O'Leary, Timothy P; Hussin, Ahmed T; Gunn, Rhian K; Brown, Richard E

2018-06-02

The APPswe/PS1dE9 mouse (line 85) is a double transgenic model of Alzheimer's disease (AD) with familial amyloid precursor protein and presenilin-1 mutations. These mice develop age-related behavioral changes reflective of the neuropsychiatric symptoms (altered anxiety-like behaviour, hyperactivity) and cognitive dysfunction (impaired learning and memory) observed in AD. The APPswe/PS1dE9 mouse has been used to examine the efficacy of therapeutic interventions on behaviour, despite previous difficulties in replicating behavioural phenotypes. Therefore, the purpose of this study was to establish the reliability of these phenotypes by further characterizing the behaviour of male APPswe/PS1dE9 and wild-type mice between 7 and 14 months of age. Mice were tested on the open-field over 5-days to examine emotionality, locomotor activity and inter-session habituation. Mice were also tested on the repeated-reversal water maze task and spontaneous alternation on the Y-maze to assess working memory. Sensori-motor gating was examined with acoustic startle and pre-pulse inhibition. Lastly contextual and cued (trace) memory was assessed with fear conditioning. The results show that among non-cognitive behaviours, APPswe/PS1dE9 mice have normal locomotor activity, anxiety-like behavior, habituation and sensori-motor gating. However, APPswe/PS1dE9 mice show impaired working memory on the repeated-reversal water-maze and impaired memory in contextual but not trace-cued fear conditioning. These results indicate that the APPswe/PS1dE9 (line 85) mice have deficits in some types of hippocampal-dependent learning and memory and, at the ages tested, APPswe/PS1dE9 mice model cognitive dysfunction but not neuropsychiatric symptoms. Copyright © 2018. Published by Elsevier Inc.

2005 Tri-Service Infrastructure Systems Conference and Exhibition. Volume 9, Tracks 9-11

DTIC Science & Technology

2005-08-04

Walls ETL 1110-2-563, by John D. Clarkson and Robert C. Patev Belleville Locks & Dam Barge Accident on 6 Jan 05, by John Clarkson Portugues Dam Project...Update, by Alberto Gonzalez, Jim Mangold and Dave Dollar Portugues Dam: RCC Materials Investigation, by Jim Hinds Nonlinear Incremental Thermal Stress...Strain Analysis Portugues Dam, by David Dollar, Ahmed Nisar, Paul Jacob and Charles Logie Seismic Isolation of Mission-Critical Infrastructure to

Study of the Decays D0→π-e+νe, D0→K-e+νe, D+→π0e+νe, and D+→ Kmacr 0e+νe

NASA Astrophysics Data System (ADS)

Cronin-Hennessy, D.; Gao, K. Y.; Gong, D. T.; Hietala, J.; Kubota, Y.; Klein, T.; Lang, B. W.; Poling, R.; Scott, A. W.; Smith, A.; Zweber, P.; Dobbs, S.; Metreveli, Z.; Seth, K. K.; Tomaradze, A.; Ernst, J.; Severini, H.; Dytman, S. A.; Love, W.; Savinov, V.; Aquines, O.; Li, Z.; Lopez, A.; Mehrabyan, S.; Mendez, H.; Ramirez, J.; Huang, G. S.; Miller, D. H.; Pavlunin, V.; Sanghi, B.; Shipsey, I. P. J.; Xin, B.; Adams, G. S.; Anderson, M.; Cummings, J. P.; Danko, I.; Napolitano, J.; He, Q.; Insler, J.; Muramatsu, H.; Park, C. S.; Thorndike, E. H.; Yang, F.; Coan, T. E.; Gao, Y. S.; Liu, F.; Artuso, M.; Blusk, S.; Butt, J.; Li, J.; Menaa, N.; Mountain, R.; Nisar, S.; Randrianarivony, K.; Redjimi, R.; Sia, R.; Skwarnicki, T.; Stone, S.; Wang, J. C.; Zhang, K.; Csorna, S. E.; Bonvicini, G.; Cinabro, D.; Dubrovin, M.; Lincoln, A.; Asner, D. M.; Edwards, K. W.; Briere, R. A.; Brock, I.; Chen, J.; Ferguson, T.; Tatishvili, G.; Vogel, H.; Watkins, M. E.; Rosner, J. L.; Adam, N. E.; Alexander, J. P.; Berkelman, K.; Cassel, D. G.; Duboscq, J. E.; Ecklund, K. M.; Ehrlich, R.; Fields, L.; Gibbons, L.; Gray, R.; Gray, S. W.; Hartill, D. L.; Heltsley, B. K.; Hertz, D.; Jones, C. D.; Kandaswamy, J.; Kreinick, D. L.; Kuznetsov, V. E.; Mahlke-Krüger, H.; Onyisi, P. U. E.; Patterson, J. R.; Peterson, D.; Pivarski, J.; Riley, D.; Ryd, A.; Sadoff, A. J.; Schwarthoff, H.; Shi, X.; Stroiney, S.; Sun, W. M.; Wilksen, T.; Weinberger, M.; Athar, S. B.; Patel, R.; Potlia, V.; Yelton, J.; Rubin, P.; Cawlfield, C.; Eisenstein, B. I.; Karliner, I.; Kim, D.; Lowrey, N.; Naik, P.; Sedlack, C.; Selen, M.; White, E. J.; Wiss, J.; Shepherd, M. R.; Besson, D.; Pedlar, T. K.

2008-06-01

By using 1.8×106 D Dmacr pairs, we have measured B(D0→π-e+νe)=0.299(11)(9)%, B(D+→π0e+νe)=0.373(22)(13)%, B(D0→K-e+νe)=3.56(3)(9)%, and B(D+→ Kmacr 0e+νe)=8.53(13)(23)% and have studied the q2 dependence of the form factors. By combining our results with recent lattice calculations, we obtain |Vcd|=0.217(9)(4)(23) and |Vcs|=1.015(10)(11)(106).

From nuclear submarines to graduate medical education: applying David Marquet's intent-based leadership model.

PubMed

Fernandez-Salvador, Camilo; Oney, Rebecca; Song, Sungjin A; Camacho, Macario

2017-10-11

L. David Marquet, a decorated Navy Captain, transformed an underperforming submarine crew by empowering his subordinates to be leaders and reach their full potential. He called this intent-based leadership (IBL). What would happen if Marquet's model were implemented in Graduate Medical Education (GME)?In this letter to the editor, we summarize the potential of the IBL model in graduate medical education as opposed to the traditional leader-follower method. IBL harnesses human productivity toward the shared goals of GME, which are patient care and trainee learning. This shift in mindset could lead both teachers and trainees to focus more on the real reason that we undertake GME and change behaviors for the better. We suggest that IBL can and should be adopted in GME and propose that both patients and providers will benefit from this action.

[Recurrent depressive disorder in Caspar David Friedrich. A pathographical approach with operationalized diagnosis].

PubMed

Spitzer, C; Dahlenburg, B; Freyberger, H J

2006-07-01

Caspar David Friedrich (1774 - 1840) is one of the most important German Romantic painters. In his paintings, he prototypically represents the melancholy, which has been mentioned by his contemporaries and later biographers. Art scientists have also referred to his melancholy for the interpretation of his work. From a medical point of view, there are only two pathographies which remain inconclusive. Having applied diagnostic criteria for psychiatric disorders to his letters and publications, to statements of his contemporaries and to his art, we propose that he had suffered from a recurrent major depression which occurred in 1799 for the first time. At least three depressive episodes followed before he was struck by a stroke in 1835. There are epidemiological, psychodynamic and personality-typological reasons supporting our diagnostic assumption. The course of his depression corresponds to phases of reduced creativity, to the chosen techniques and motives. Finally we discuss the implications of our approach for the pathographical method in general.

CRIS Cyber Range Lexicon Version 1.0 (Report 59 0001)

DTIC Science & Technology

2015-11-27

Evaluation (T&E) Support Cell, TRMC/ Northrop Grumman ) Dr. David “Fuzzy” Wells (USPACOM) Mr. Bennett Wilson (NAVSEA GOV – CDSA, Damneck...9 Figure 4: Planes and Teams...Communities supported by the CRIS WG include, but are not limited to, Science & Technology (S&T) experimentation , Developmental and Operational Test and

IL-9–producing cells in the development of IgE-mediated food allergy

PubMed Central

Shik, Dana; Tomar, Sunil; Lee, Jee-Boong; Chen, Chun-Yu; Smith, Andrew; Wang, Yui-Hsi

2016-01-01

Food allergy is a harmful immune reaction driven by uncontrolled type-2 immune responses. Considerable evidence demonstrates the key roles of mast cells, IgE, and TH2 cytokines in mediating food allergy. However, this evidence provides limited insight into why only some, rather than all, food allergic individuals are prone to develop life-threatening anaphylaxis. Clinical observations suggest that patients sensitized to food through the skin early in life may later develop severe food allergies. Aberrant epidermal thymic stromal lymphopoietin and interleukin (IL) 33 production and genetic predisposition can initiate an allergic immune response mediated by dendritic cells and CD4+TH2 cells in inflamed skin. After allergic sensitization, intestinal IL-25 and food ingestion enhance concerted interactions between type-2 innate lymphoid cells (ILC2s) and CD4+TH2 cells, which perpetuate allergic reactions from skin to the gut. IL-4 and crosslinking of antigen/IgE/FcεR complexes induce emigrated mast cell progenitors to develop into the multi-functional IL-9–producing mucosal mast cells, which produce prodigious amounts of IL-9 and mast cell mediators to drive intestinal mastocytosis in an autocrine loop. ILC2s and TH9 cells may also serve as alternative cellular sources of IL-9 to augment the amplification of intestinal mastocytosis, which is the key cellular checkpoint in developing systemic anaphylaxis. These findings provide a plausible view of how food allergy develops and progresses in a stepwise manner and that atopic signals, dietary allergen ingestion, and inflammatory cues are fundamental in promoting life-threatening anaphylaxis. This information will aid in improving diagnosis and developing more effective therapies for food allergy–triggered anaphylaxis. PMID:27909880

Astronaut James McDivitt photographed inside Command Module during Apollo 9

NASA Image and Video Library

1969-03-06

AS09-20-3154 (3-13 March 1969) --- This close-up view of astronaut James A. McDivitt shows several days' beard growth. The Apollo 9 mission commander was onboard the Lunar Module (LM) "Spider" in Earth orbit, near the end of the flight. He was joined on the mission by astronauts David R. Scott, command module pilot, and Russell L. Schweickart, lunar module pilot. Schweickart took this picture while Scott remained in the Command Module (CM) "Gumdrop." In Earth orbit, the three tested the transposition and docking systems of the lunar module and command module. On a scheduled lunar landing mission later this year, a team of three astronauts and ground controllers will use what this crew and its support staff have learned in handling the systems of the two spacecraft.

An Automated Individual Training Record Management System (Prototype) United States Marine Corps

DTIC Science & Technology

1984-03-01

PERFORMING ORG. REPORT NUMBER 7. AUTHO(a) 9. CONTRACT OR GRANT NUMBER(@) Ronald E. Pruiett David P. Haeusler 9. PERFORMING ORGANIZATION NAME AND ADDRESS...10. PROGRAM ELEMENT. PROJECT. TASK AREA & WORK UNIT NUMBERS Naval Postgraduate School Monterey, CA 93943 11. CONTROL.LING OFFICE NAME AND ADDRESS 12...ane individuel levels of performance . Since the focus is cn individual training ard individual testing, data m s atntained for each individual in a

Vacuum-UV fluorescence spectroscopy of PF3 in the range 9-20 eV

NASA Astrophysics Data System (ADS)

Biehl, H.; Boyle, K. J.; Seccombe, D. P.; Tuckett, R. P.; Baumgärtel, H.; Jochims, H. W.

1998-01-01

The vacuum-UV and visible spectroscopy of PF3 using fluorescence excitation and dispersed emission techniques is reported. The fluorescence excitation spectrum has been recorded following photoexcitation with monochromatized synchrotron radiation from the Daresbury, UK source in the energy range 9-20 eV with an average resolution of ˜0.015 eV. Transitions to the three lowest-energy bands in the Rydberg spectra show resolved vibrational structure, they are assigned to transitions to the (8a1)-1 4p, 5p, and 6p Rydberg states of PF3, and fluorescence is due to valence transitions in the PF2 radical. From a Franck-Condon analysis of the vibrational structure, it is shown that the FPF bond angle in PF3 increases by ˜14±1° upon photoexcitation. The use of optical filters shows that at least three excited electronic states of PF2 are responsible for the induced emission. Dispersed emission spectra in the UV/visible region have been recorded with an optical resolution of 8 nm at the BESSY 1, Germany synchrotron source at the energies of all the peaks in the excitation spectrum. Four different decay channels are observed: (a) PF2 Ã 2A1-X˜2B1 fluorescence in the wide range 320-550 nm for photon energies around 9.8 eV, (b) PF2 ÖX˜, and B˜ 2B2-X˜ 2B1 fluorescence at ˜300 nm for photon energies around 11.0 eV, (c) PF2 C˜ 2A1-X˜ 2B1 and Ẽ 2B1 (2Π)-Ã 2A1 fluorescence at ˜222 and 325 nm, respectively, for photon energies around 14.4 eV, and (d) PF A 3Π-X 3Σ- fluorescence between 300-380 nm for photon energies around 16.1 eV. These assignments are confirmed by action spectra in which the excitation energy of the vacuum-UV radiation is scanned with detection of the fluorescence at a fixed, dispersive wavelength. Using the single-bunch mode of the BESSY 1 source, we have attempted to measure the lifetimes of the emitting states, but the timing profile of the source imposes an upper limit on lifetimes that can be measured of ˜500 ns. We have therefore only been

How David P. Weikart's Highscope Summer Camp for (Gifted) Teenagers Became a Sustainable Model for My Later Work in Special Education and Inclusive Education

ERIC Educational Resources Information Center

Broecher, Joachim

2015-01-01

The HighScope Summer Camp for Teenagers founded by David P. Weikart in 1963, and operated until 2002, was an international, inclusive gifted education program that aided many young people, including those from disadvantaged social strata, in their personal development and shaped them in a special way. The six-week program stood for a high degree…

Identification, Characterization and Clinical Development of the New Generation of Breast Cancer Susceptibility Alleles

DTIC Science & Technology

2011-03-01

Neil M Walker2, Nicholas A Watkins8,9, Thilo Winzer8, John A Todd2, Willem H Ouwehand8,9 1958 Birth Cohort Controls: Richard W Jones18, Wendy L...Sarah Nutland2, Helen E Stevens2, Neil M Walker2, Barry Widmer2,41, John A Todd2 Type 2 Diabetes (Exeter): Timothy M Frayling42,43, Rachel M...Ravindrarajah5, Pamela Whittaker5, Claire Widden5, David Withers5, Panos Deloukas5; (Cambridge): Hin Tak Leung2, Sarah Nutland2, Helen E Stevens2, Neil M

The David Jayne amendment: the story of one man's determination to improve the lives of thousands.

PubMed

Sokol, Eric

2003-09-01

Stricken by ALS at the age of 27, David Jayne slowly lost the ability to walk, to eat, to speak, and to breathe. With the assistance of home health professionals, medical technologies, and volunteers, he has managed to maintain as full a life as possible, participating in some of his children's activities and even managing, with great effort, to attend a football game. However, when he was the subject of a newspaper article, his home health coverage was dropped because he didn't meet the federal definition of "homebound." This is the story of how he took on the political establishment single-handedly, and eventually realized a victory that has the potential of helping thousands of people in similar situations to no longer be imprisoned at home.

Algorithm-Eigenvalue Estimation of Hyperspectral Wishart Covariance Matrices from a Limited Number of Samples

DTIC Science & Technology

2015-03-01

ALGORITHM—EIGENVALUE ESTIMATION OF HYPERSPECTRAL WISHART COVARIANCE MATRICES FROM A LIMITED NUMBER OF SAMPLES ECBC-TN-067 Avishai Ben- David ...NUMBER 6. AUTHOR(S) Ben- David , Avishai (ECBC) and Davidson, Charles E. (STC) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7...and published by Avishai Ben- David and Charles E. Davidson (Eigenvalue Estimation of Hyperspectral WishartCovariance Matrices from Limited Number of

One-step genetic correction of hemoglobin E/beta-thalassemia patient-derived iPSCs by the CRISPR/Cas9 system.

PubMed

Wattanapanitch, Methichit; Damkham, Nattaya; Potirat, Ponthip; Trakarnsanga, Kongtana; Janan, Montira; U-Pratya, Yaowalak; Kheolamai, Pakpoom; Klincumhom, Nuttha; Issaragrisil, Surapol

2018-02-26

Thalassemia is the most common genetic disease worldwide; those with severe disease require lifelong blood transfusion and iron chelation therapy. The definitive cure for thalassemia is allogeneic hematopoietic stem cell transplantation, which is limited due to lack of HLA-matched donors and the risk of post-transplant complications. Induced pluripotent stem cell (iPSC) technology offers prospects for autologous cell-based therapy which could avoid the immunological problems. We now report genetic correction of the beta hemoglobin (HBB) gene in iPSCs derived from a patient with a double heterozygote for hemoglobin E and β-thalassemia (HbE/β-thalassemia), the most common thalassemia syndrome in Thailand and Southeast Asia. We used the CRISPR/Cas9 system to target the hemoglobin E mutation from one allele of the HBB gene by homology-directed repair with a single-stranded DNA oligonucleotide template. DNA sequences of the corrected iPSCs were validated by Sanger sequencing. The corrected clones were differentiated into hematopoietic progenitor and erythroid cells to confirm their multilineage differentiation potential and hemoglobin expression. The hemoglobin E mutation of HbE/β-thalassemia iPSCs was seamlessly corrected by the CRISPR/Cas9 system. The corrected clones were differentiated into hematopoietic progenitor cells under feeder-free and OP9 coculture systems. These progenitor cells were further expanded in erythroid liquid culture system and developed into erythroid cells that expressed mature HBB gene and HBB protein. Our study provides a strategy to correct hemoglobin E mutation in one step and these corrected iPSCs can be differentiated into hematopoietic stem cells to be used for autologous transplantation in patients with HbE/β-thalassemia in the future.

E-cadherin expression in sporadic gastric cancer from Mexico: exon 8 and 9 deletions are infrequent events associated with poor survival.

PubMed

Gamboa-Dominguez, Armando; Dominguez-Fonseca, Claudia; Chavarri-Guerra, Yanin; Vargas, Roberto; Reyes-Gutierrez, Edgardo; Green, Dan; Quintanilla-Martinez, Leticia; Luber, Birgit; Busch, Raymonde; Becker, Karl-Friedrich; Becker, Ingrid; Höfler, Heinz; Fend, Falko

2005-01-01

Aberrant expression and mutation of E-cadherin is frequent in gastric carcinoma (GC) especially of the diffuse type. The frequency of CDH1 (gene encoding E-cadherin) mutation in populations with high incidence of diffuse GC and its prognostic significance is unknown. One hundred seventy-seven gastrectomies from Mexican mestizo patients with intestinal (53), mixed (55), or diffuse (69) GC were included. In addition, 101 endoscopic biopsies from patients with GC not subjected to surgery were analyzed. Immunohistochemistry against wild-type E-cadherin (clone 36) and against 2 mutation-specific antibodies (MSA) recognizing mutant CDH1 lacking exon-8 (del 8) or exon-9 (del 9) were performed. Staining was correlated with histotype, tumor node metastasis stage, and follow-up. Abnormal or absent E-cadherin expression (clone 36) was identified in 84% GC, predominantly in diffuse or mixed tumors (P = 0.004) in advanced stages (P = 0.003). No survival differences at 1 and 2 years were observed among patients showing normal, abnormal, or absent wild type E-cadherin expression. Overall reactivity with the MSA was observed in 10 (5.6%) patients who were treated with surgery. In 140 patients, dead from the disease or alive with the disease, the survival at 1 and 2 years was 37% versus 17% and 14% versus 0 for patients without and with del 8/9 positivity, respectively (log rank P = 0.01). Biopsies from patients with inoperable-GC (101) rendered 5 (4.95%) with del 8 or 9 immunoreactivity. Abnormal E-cadherin expression is frequent in GC. However, exon 8 or 9 deletions were observed in only 5.3% tumors in this series from Mexico, at a lower rate than previously published, but associated with a worse prognosis.

9. Photograph of a line drawing. SHEET 9, LONGITUDINAL SECTION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photograph of a line drawing. SHEET 9, LONGITUDINAL SECTION ON LINE AA; 9-16-1940. Assembly Building for Tank Plant for the Chrysler Corporation, Macomb County, Michigan. Delineator: E.B. - Detroit Arsenal, 6501 East Eleven Mile Road, Warren, Macomb County, MI

jsc2018e050027

NASA Image and Video Library

2018-05-19

jsc2018e050027 - At the Gagarin Cosmonaut Training Center in Star City, Russia, the Expedition 56 prime and backup crewmembers pose for pictures in front of the statue of Vladimir Lenin May 19 before boarding a bus that took them to a nearby airfield for a flight to their launch site at the Baikonur Cosmodrome in Kazakhstan. From left to right are the backup crewmembers, Anne McClain of NASA, Oleg Kononenko of Roscosmos and David Saint-Jacques of the Canadian Space Agency, and the prime crew, Serena Aunon-Chancellor of NASA, Sergey Prokopyev of Roscosmos and Alexander Gerst of the European Space Agency. Aunon-Chancellor, Prokopyev and Gerst will launch June 6 on the Soyuz MS-09 spacecraft from Baikonur for a six-month mission on the International Space Station...NASA/Elizabeth Weissinger.

High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k "Helper" Proteins.

PubMed

Gwiazda, Kamila S; Grier, Alexandra E; Sahni, Jaya; Burleigh, Stephen M; Martin, Unja; Yang, Julia G; Popp, Nicholas A; Krutein, Michelle C; Khan, Iram F; Jacoby, Kyle; Jensen, Michael C; Rawlings, David J; Scharenberg, Andrew M

2016-09-29

Many future therapeutic applications of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 and related RNA-guided nucleases are likely to require their use to promote gene targeting, thus necessitating development of methods that provide for delivery of three components-Cas9, guide RNAs and recombination templates-to primary cells rendered proficient for homology-directed repair. Here, we demonstrate an electroporation/transduction codelivery method that utilizes mRNA to express both Cas9 and mutant adenoviral E4orf6 and E1b55k helper proteins in association with adeno-associated virus (AAV) vectors expressing guide RNAs and recombination templates. By transiently enhancing target cell permissiveness to AAV transduction and gene editing efficiency, this novel approach promotes efficient gene disruption and/or gene targeting at multiple loci in primary human T-cells, illustrating its broad potential for application in translational gene editing.

Malaria severity: Possible influence of the E670G PCSK9 polymorphism: A preliminary case-control study in Malian children.

PubMed

Arama, Charles; Diarra, Issa; Kouriba, Bourèma; Sirois, Francine; Fedoryak, Olesya; Thera, Mahamadou A; Coulibaly, Drissa; Lyke, Kirsten E; Plowe, Christopher V; Chrétien, Michel; Doumbo, Ogobara K; Mbikay, Majambu

2018-01-01

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a hepatic secretory protein which promotes the degradation of low-density lipoprotein receptors leading to reduced hepatic uptake of plasma cholesterol. Non-synonymous single-nucleotide polymorphisms in its gene have been linked to hypo- or hyper- cholesterolemia, depending on whether they decrease or increase PCSK9 activity, respectively. Since the proliferation and the infectivity of Plasmodium spp. partially depend on cholesterol from the host, we hypothesize that these PCSK9 genetic polymorphisms could influence the course of malaria infection in individuals who carry them. Here we examined the frequency distribution of one dominant (C679X) and two recessive (A443T, I474V) hypocholesterolemic polymorphisms as well as that of one recessive hypercholesterolemic polymorphism (E670G) among healthy and malaria-infected Malian children. Dried blood spots were collected in Bandiagara, Mali, from 752 age, residence and ethnicity-matched children: 253 healthy controls, 246 uncomplicated malaria patients and 253 severe malaria patients. Their genomic DNA was extracted and genotyped for the above PCSK9 polymorphisms using Taqman assays. Associations of genotype distributions and allele frequencies with malaria were evaluated. The minor allele frequency of the A443T, I474V, E670G, and C679X polymorphisms in the study population sample was 0.12, 0.20, 0.26, and 0.02, respectively. For each polymorphism, the genotype distribution among the three health conditions was statistically insignificant, but for the hypercholesterolemic E670G polymorphism, a trend towards association of the minor allele with malaria severity was observed (P = 0.035). The association proved to be stronger when allele frequencies between healthy controls and severe malaria cases were compared (Odd Ratio: 1.34; 95% Confidence Intervals: 1.04-1.83); P = 0.031). Carriers of the minor allele of the E670G PCSK9 polymorphism might be more susceptible

Amelioration of cognitive impairments in APPswe/PS1dE9 mice is associated with metabolites alteration induced by total salvianolic acid

PubMed Central

Shen, Li; Han, Bing; Geng, Yuan; Wang, Jinhua; Wang, Zhengmin

2017-01-01

Purpose Total salvianolic acid (TSA) is extracted from salvia miltiorrhiza; however, to date, there has been limited characterization of its effects on metabolites in Alzheimer’s disease model-APPswe/PS1dE9 mice. The main objective of this study was to investigate the metabolic changes in 7-month-old APPswe/PS1dE9 mice treated with TSA, which protects against learning and memory impairment. Methods APPswe/PS1dE9 mice were treated with TSA (30 mg/kg·d and 60 mg/kg·d, i.p.) and saline (i.p.) daily from 3.5 months old for 14 weeks; saline-treated (i.p.) WT mice were included as the controls. The effects of TSA on learning and memory were assessed by a series of behavioral tests, including the NOR, MWM and step-through tasks. The FBG and plasma lipid levels were subsequently assessed using the GOPOD and enzymatic color methods, respectively. Finally, the concentrations of Aβ42, Aβ40 and metabolites in the hippocampus of the mice were detected via ELISA and GC-TOF-MS, respectively. Results At 7 months of age, the APPswe/PS1dE9 mice treated with TSA exhibited an improvement in the preference index (PI) one hour after the acquisition phase in the NOR and the preservation of spatial learning and memory in the MWM. Treatment with TSA substantially decreased the LDL-C level, and 60 mg/kg TSA decreased the CHOL level compared with the plasma level of the APPswe/PS1dE9 group. The Aβ42 and Aβ40 levels in the hippocampus were decreased in the TSA-treated group compared with the saline-treated APPswe/PS1dE9 group. The regulation of metabolic pathways relevant to TSA predominantly included carbohydrate metabolism, such as sorbitol, glucose-6-phosphate, sucrose-6-phosphate and galactose, vitamin metabolism involved in cholecalciferol and ascorbate in the hippocampus. Conclusions TSA induced a remarkable amelioration of learning and memory impairments in APPswe/PS1dE9 mice through the regulation of Aβ42, Aβ40, carbohydrate and vitamin metabolites in the hippocampus and LDL

Evaluation of the longer-term use of the David Hart Walker Orthosis by children with cerebral palsy: a 3-year prospective evaluation.

PubMed

Wright, F Virginia; Jutai, Jeffrey W

2006-06-01

To evaluate a walking device, the David Hart Walker Orthosis (HW), that was designed to allow children with severe cerebral palsy to ambulate with hands-free support. A pre-/post-test prospective one-group study evaluated outcomes three years after receiving the HW. Physical therapy assessment, parent interview and satisfaction questionnaire provided details on outcomes. The HW remained the sole walking device for 13 of 20 children at 3 years. Six of seven children who discontinued use were over 12-years-old and had outgrown its maximum size. Twelve of 13 children who still used the HW were assessed. GMFM Stand and Walk Dimension mean score increases of about 3% points for the 1- 3-year follow-up were not significant (P > 0.16). Timed walk scores were unchanged. Steering ability gains were demonstrated on a directional mobility assessment (from 12.0 to 27.9% [P= 0.02]). Despite its eventual height limitations, parents considered HW use to be worthwhile (mean satisfaction = 8.2/10). Sixty-five percent of the children continued to use the HW as their sole walking device, and demonstrated improved ability overall to manoeuvre it during functional ambulation. The primary reason for discontinuation was inability to accommodate taller children.

MicroRNA-9 up-regulates E-cadherin through inhibition of NF-κB1-Snail1 pathway in melanoma.

PubMed

Liu, Shujing; Kumar, Suresh M; Lu, Hezhe; Liu, Aihua; Yang, Ruifeng; Pushparajan, Anitha; Guo, Wei; Xu, Xiaowei

2012-01-01

MicroRNAs (miRNAs) are short non-coding RNAs that post-transcriptionally regulate gene expression. Hsa-miR-9 has been shown to have opposite functions in different tumour types; however, the underlying mechanism is unclear. Here we show that hsa-miR-9 is down-regulated in metastatic melanomas compared to primary melanomas. Overexpression of miR-9 in melanoma cells resulted in significantly decreased cell proliferation and migratory capacity with decreased F-actin polymerization and down-regulation of multiple GTPases involved in cytoskeleton remodelling. miR-9 overexpression induced significant down-regulation of Snail1 with a concomitant increase in E-cadherin expression. In contrast, knockdown of miR-9 increased Snail1 expression as well as melanoma cell proliferation and migration capacity. Mechanistically, miR-9 expression down-regulated NF-κB1 in melanoma and the effect was abolished by mutations in the putative miR-9 binding sites within the 3'-untranslated region (UTR) of NF-κB1. Anti-miR-9 miRNA inhibitor also increased the expression of NF-κB1. The effects of miR-9 on Snail1 expression and melanoma cell proliferation and migration were rescued by overexpression of NF-κB1 in these cells. Furthermore, miR-9 overexpression resulted in significantly decreased melanoma growth and metastasis in vivo. In summary, miR-9 inhibits melanoma proliferation and metastasis through down-regulation of the NF-κB1-Snail1 pathway. This study finds a new mechanism that miR-9 utilizes to decrease E-cadherin expression and inhibit melanoma progression. The results suggest that function of microRNAs is context and tumour type-specific. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Energy-density and repetition-rate dependences of the KrF-excimer-laser-induced 1.9-eV emission band in type-III fused silicas

NASA Astrophysics Data System (ADS)

Kuzuu, Nobu; Komatsu, Yoshikazu; Murahara, Masataka

1993-02-01

The energy-density and repetition-rate dependences of the intensity of KrF-excimer-laser (5.0 eV) -induced 1.9-eV emission band in type-III fused silicas synthesized under different conditions were investigated. The intensity of the 1.9-eV band is proportional to the 1.7-th power of the energy density and the 0.6-th power of the repetition rate of the laser pulse. The origin of these dependencies was discussed based on the trapped-oxygen-molecule model proposed by Awazu and Kawazoe; by irradiating with the excimer laser, ozone molecules are formed from dissolved oxygen molecules and 1.9-eV photons are emitted in the course of the photodecomposition of the ozone molecules. Therefore, a two-step photon-absorption process is needed to emit the 1.9-eV photon. To form the ozone molecule, diffusion of the oxygen atoms produced by the photodecomposition of the trapped oxygen molecules are needed. This model suggests that the intensity of the 1.9-eV band is proportional to the square of the energy density and the square root of the repetition rate; this dependency is nearly the same as that of our experimental result.

Airborne Science personnel Walter Klein and David Bushman at the Mission Manager's console onboard NASA's DC-8 during the AirSAR 2004 campaign

NASA Image and Video Library

2004-03-03

Airborne Science personnel Walter Klein and David Bushman at the Mission Manager's console onboard NASA's DC-8 during the AirSAR 2004 campaign. AirSAR 2004 is a three-week expedition by an international team of scientists that will use an all-weather imaging tool, called the Airborne Synthetic Aperture Radar (AirSAR), in a mission ranging from the tropical rain forests of Central America to frigid Antarctica.

MQ-9 Reaper Unmanned Aircraft System (MQ-9 Reaper)

DTIC Science & Technology

2013-12-01

Milestone C ACAT II Block 1 FEB 2008 FEB 2008 FEB 2008 FEB 2008 IOT&E for Block 1 MAY 2008 MAY 2008 MAY 2008 MAY 2008 RAA SEP 2010 JUN 2012 JUN 2012 JUN...milestone change. Memo MQ-9 Reaper December 2013 SAR April 16, 2014 17:17:09 UNCLASSIFIED 9 RAA includes two fixed GCSs, two mobile GCSs...Control Station IOT&E - Initial Operational Test and Evaluation PMAI - Primary Mission Aircraft Inventory PO - Program Office RAA - Required Assets

COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer.

PubMed

Gao, Shujun; Fang, Lekun; Phan, Liem Minh; Qdaisat, Aiham; Yeung, Sai-Ching J; Lee, Mong-Hong

2015-09-29

Cervical cancer is one of the leading causes of cancer death in women. Human papillomaviruses (HPVs) are the major cause in almost 99.7% of cervical cancer. E6 oncoprotein of HPV and E6-associated protein (E6AP) are critical in causing p53 degradation and malignancy. Understanding the E6AP regulation is critical to develop treating strategy for cervical cancer patients. The COP9 signalosome subunit 6 (CSN6) is involved in ubiquitin-mediated protein degradation. We found that both CSN6 and E6AP are overexpressed in cervical cancer. We characterized that CSN6 associated with E6AP and stabilized E6AP expression by reducing E6AP poly-ubiquitination, thereby regulating p53 activity in cell proliferation and apoptosis. Mechanistic studies revealed that CSN6-E6AP axis can be regulated by EGF/Akt signaling. Furthermore, inhibition of CSN6-E6AP axis hinders cervical cancer growth in mice. Taken together, our results indicate that CSN6 is a positive regulator of E6AP and is important for cervical cancer development.

Peroxygenase-Catalyzed Fatty Acid Epoxidation in Cereal Seeds (Sequential Oxidation of Linoleic Acid into 9(S),12(S),13(S)-Trihydroxy-10(E)-Octadecenoic Acid).

PubMed Central

Hamberg, M.; Hamberg, G.

1996-01-01

Peroxygenase-catalyzed epoxidation of oleic acid in preparations of cereal seeds was investigated. The 105,000g particle fraction of oat (Avena sativa) seed homogenate showed high peroxygenase activity, i.e. 3034 [plus or minus] 288 and 2441 [plus or minus] 168 nmol (10 min)-1 mg-1 protein in two cultivars, whereas the corresponding fraction obtained from barley (Hordeum vulgare and Hordeum distichum), rye (Secale cereale), and wheat (Triticum aestivum) showed only weak activity, i.e. 13 to 138 nmol (10 min)-1 mg-1 protein. In subcellular fractions of oat seed homogenate, peroxygenase specific activity was highest in the 105,000g particle fraction, whereas lipoxygenase activity was more evenly distributed and highest in the 105,000g supernatant fraction. Incubation of [1-14C]linoleic acid with the 105,000g supernatant of oat seed homogenate led to the formation of several metabolites, i.e. in order of decreasing abundance, 9(S)-hydroxy-10(E),12(Z)-octadecadienoic acid, 9(S),12(S),13(S)-trihydroxy-10(E)-octadecenoic acid, cis-9,10-epoxy-12(Z)-octadecenoic acid [mainly the 9(R),10(S) enantiomer], cis-12,13-epoxy-9(Z)-octadecenoic acid [mainly the 12(R),13(S) enantiomer], threo-12,13-dihydroxy-9(Z)-octadecenoic acid, and 12(R),13(S)-epoxy-9(S)-hydroxy-10(E)-octadecenoic acid. Incubation of linoleic acid with the 105,000g particle fraction gave a similar, but not identical, pattern of metabolites. Conversion of linoleic acid into 9(S),12(S),13(S)-trihydroxy-10(E)-octadecenoic acid, a naturally occurring oxylipin with antifungal properties, took place by a pathway involving sequential catalysis by lipoxygenase, peroxygenase, and epoxide hydrolase. PMID:12226220

Expression and regulation of ATL9, an E3 ubiquitin ligase involved in plant defense

PubMed Central

Lefebvre, Mitchell; Scaglione, Steven; Antico, Christopher J.; Jing, Tao; Yang, Xin; Shan, Weixing

2017-01-01

Plants are continually exposed to a variety of pathogenic organisms, including bacteria, fungi and viruses. In response to these assaults, plants have developed various defense pathways to protect themselves from pathogen invasion. An understanding of the expression and regulation of genes involved in defense signaling is essential to controlling plant disease. ATL9, an Arabidopsis RING zinc finger protein, is an E3 ubiquitin ligase that is induced by chitin and involved in basal resistance to the biotrophic fungal pathogen, Golovinomyces cichoracearum (G. cichoracearum). To better understand the expression and regulation of ATL9, we studied its expression pattern and the functions of its different protein domains. Using pATL9:GUS transgenic Arabidopsis lines we found that ATL9 is expressed in numerous tissues at various developmental stages and that GUS activity was induced rapidly upon wounding. Using a GFP control protein, we showed that ATL9 is a short-lived protein within plant cells and it is degraded via the ubiquitin-proteasome pathway. ATL9 contains two transmembrane domains (TM), a RING zinc-finger domain, and a PEST domain. Using a series of deletion mutants, we found that the PEST domain and the RING domain have effects on ATL9 degradation. Further infection assays with G. cichoracearum showed that both the RING domain and the TM domains are important for ATL9’s resistance phenotype. Interestingly, the PEST domain was also shown to be significant for resistance to fungal pathogens. This study demonstrates that the PEST domain is directly coupled to plant defense regulation and the importance of protein degradation in plant immunity. PMID:29161311

Radiobiology of Large Animals

DTIC Science & Technology

1975-06-01

efforts of James L. Thomas, Richard K. Marshall, and David E. Moore. iii L.,.„. mm mm ABSTRACT The LD5QS for sheep exposed to 60Co gamma rays at 0.9...25, 480-488 (1965). 7. J. S. Krebs, R. W. Brauer, and H. Kalbach , The estimation of the non-recuperable injury caused by ionizing radiation

Apollo 40th Anniversary Press Conference

NASA Image and Video Library

2009-07-19

Astronaut James Lovell (Apollo 8 Apollo 13), center, flanked by Walt Cunningham (Apollo 7), left, and David Scott (Apollo 9 Apollo 15) responds during the 40th anniversary of the Apollo 11 mission and the walk on the moon press conference, Monday, July 20, 2009, at NASA Headquarters in Washington. Photo Credit: (NASA/Paul E. Alers)

Natural Fatigue Crack Initiation and Detection in High Quality Spur Gears

DTIC Science & Technology

2012-06-01

Natural Fatigue Crack Initiation and Detection in High Quality Spur Gears by David “Blake” Stringer, Ph.D., Kelsen E. LaBerge, Ph.D., Cory...0383 June 2012 Natural Fatigue Crack Initiation and Detection in High Quality Spur Gears David “Blake” Stringer and Ph.D., Kelsen E. LaBerge...Quality Spur Gears 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) David “Blake” Stringer, Ph.D., Kelsen E

COP9 signalosome subunit PfCsnE regulates secondary metabolism and conidial formation in Pestalotiopsis fici.

PubMed

Zheng, Yanjing; Wang, Xiuna; Zhang, Xiaoling; Li, Wei; Liu, Gang; Wang, Shihua; Yan, Xiufeng; Zou, Huixi; Yin, Wen-Bing

2017-06-01

The COP9 signalosome (CSN) is a highly conserved multiprotein complex in all eukaryotes and involved in regulation of organism development. In filamentous fungi, several lines of evidence indicate that fungal development and secondary metabolism (SM) are mediated by the fifth subunit of CSN, called CsnE. Here we uncover a connection with CsnE and conidial formation as well as SM regulation in the plant endophytic fungus Pestalotiopsis fici. A homology search of the P. fici genome with CsnE, involved in sexual development and SM in Aspergillus nidulans, identified PfCsnE. Deletion of PfcsnE resulted in a mutant that stopped conidial production, but the conidia are recovered in a PfcsnE complemented strain. This indicates that PfCsnE is required for the formation of conidia. Secondary metabolite analysis demonstrated that the ΔPfcsnE strain produced more chloroisosulochrin, less ficiolide A production in comparison to wild type (WT). Transcriptome analysis of WT and ΔPfcsnE strains indicated that PfcsnE impacts the expression levels of 8.37% of 14,797 annotated genes. Specifically, nine biosynthetic gene clusters (BGCs) were up-regulated and three BGCs were down-regulated by PfCsnE. Our results suggest that PfCsnE plays major roles in SM regulation and conidial development in P. fici.

RP-1 delivered to E-1 Test Stand

NASA Image and Video Library

2010-03-30

NASA John C. Stennis Space Center employee Dustan Ladner (left) assists tanker driver David Velasco in transferring RP-1 fuel to a 20,000-gallon underground tank at the E-1 Test Stand during a March 30 delivery. The rocket propellant will be used for testing Aerojet AJ26 rocket engines beginning this summer. Stennis is testing the engines for Orbital Sciences Corporation, which has partnered with NASA to provide eight supply missions to the International Space Station through 2015. The partnership is part of NASA's Commercial Orbital Transportation Services initiative to work closer with companies to provide commercial space transport once the space shuttle is retired later this year.

Purification and characterization of 9-hexadecenoic acid cis-trans isomerase from pseudomonas sp. strain E-3

PubMed

Okuyama; Ueno; Enari; Morita; Kusano

1998-01-01

A 9-hexadecenoic acid cis-trans isomerase (9-isomerase) that catalyzed the cis-to-trans isomerization of the double bond of free 9-cis-hexadecenoic acid [16:1(9c)] was purified to homogeneity from an extract of Pseudomonas sp. strain E-3 and characterized. Electrophoresis of the purified enzyme on both incompletely denaturing and denaturing polyacrylamide gels yielded a single band of a protein with a molecular mass of 80 kDa, suggesting that the isomerase is a monomeric protein of 80 kDa. The 9-isomerase, assayed with 16:1(9c) as a substrate, had a specific activity of 22.8 &mgr;mol h-1 (mg protein)-1 and a Km of 117.6 mM. The optimal pH and temperature for catalysis were approximately pH 7-8 and 30 degrees C, respectively. The 9-isomerase catalyzed the cis-to-trans conversion of a double bond at positions 9, 10, or 11, but not that of a double bond at position 6 or 7 of cis-mono-unsaturated fatty acids with carbon chain lengths of 14, 15, 16, and 17. Octadecenoic acids with a double bond at position 9 or 11 were not susceptible to isomerization. These results suggest that 9-isomerase has a strict specificity for both the position of the double bond and the chain length of the fatty acid. The enzyme catalyzed the cis-to-trans isomerization of fatty acids in a free form, and in the presence of a membrane fraction it was also able to isomerize 16:1(9c) esterified to phosphatidylethanolamine. The 9-isomerase was strongly inhibited by catecholic antioxidants such as alpha-tocopherol and nordihydroguaiaretic acid, but was not inhibited by 1, 10-phenanthroline or EDTA or under anoxic conditions. Based on these results, the possible mechanism of catalysis by this enzyme is discussed.

Study of the semileptonic charm decays D0→π-e+νe, D+→π0e+νe, D0→K-e+νe, and D+→ Kmacr 0e+νe

NASA Astrophysics Data System (ADS)

Dobbs, S.; Metreveli, Z.; Seth, K. K.; Tomaradze, A.; Ernst, J.; Severini, H.; Dytman, S. A.; Love, W.; Savinov, V.; Aquines, O.; Li, Z.; Lopez, A.; Mehrabyan, S.; Mendez, H.; Ramirez, J.; Huang, G. S.; Miller, D. H.; Pavlunin, V.; Sanghi, B.; Shipsey, I. P. J.; Xin, B.; Adams, G. S.; Anderson, M.; Cummings, J. P.; Danko, I.; Napolitano, J.; He, Q.; Insler, J.; Muramatsu, H.; Park, C. S.; Thorndike, E. H.; Yang, F.; Coan, T. E.; Gao, Y. S.; Liu, F.; Artuso, M.; Blusk, S.; Butt, J.; Li, J.; Menaa, N.; Mountain, R.; Nisar, S.; Randrianarivony, K.; Redjimi, R.; Sia, R.; Skwarnicki, T.; Stone, S.; Wang, J. C.; Zhang, K.; Csorna, S. E.; Bonvicini, G.; Cinabro, D.; Dubrovin, M.; Lincoln, A.; Asner, D. M.; Edwards, K. W.; Briere, R. A.; Brock, I.; Chen, J.; Ferguson, T.; Tatishvili, G.; Vogel, H.; Watkins, M. E.; Rosner, J. L.; Adam, N. E.; Alexander, J. P.; Berkelman, K.; Cassel, D. G.; Duboscq, J. E.; Ecklund, K. M.; Ehrlich, R.; Fields, L.; Gibbons, L.; Gray, R.; Gray, S. W.; Hartill, D. L.; Heltsley, B. K.; Hertz, D.; Jones, C. D.; Kandaswamy, J.; Kreinick, D. L.; Kuznetsov, V. E.; Mahlke-Krüger, H.; Onyisi, P. U. E.; Patterson, J. R.; Peterson, D.; Pivarski, J.; Riley, D.; Ryd, A.; Sadoff, A. J.; Schwarthoff, H.; Shi, X.; Stroiney, S.; Sun, W. M.; Wilksen, T.; Weinberger, M.; Athar, S. B.; Patel, R.; Potlia, V.; Yelton, J.; Rubin, P.; Cawlfield, C.; Eisenstein, B. I.; Karliner, I.; Kim, D.; Lowrey, N.; Naik, P.; Sedlack, C.; Selen, M.; White, E. J.; Wiss, J.; Shepherd, M. R.; Besson, D.; Pedlar, T. K.; Cronin-Hennessy, D.; Gao, K. Y.; Gong, D. T.; Hietala, J.; Kubota, Y.; Klein, T.; Lang, B. W.; Poling, R.; Scott, A. W.; Smith, A.; Zweber, P.

2008-06-01

Using a sample of 1.8 million D Dmacr mesons collected at the ψ(3770) with the CLEO-c detector, we study the semileptonic decays D0→π-e+νe, D+→π0e+νe, D0→K-e+νe, and D+→ Kmacr 0e+νe. For the total branching fractions we find B(D0→π-e+νe)=0.299(11)(9)%, B(D+→π0e+νe)=0.373(22)(13)%, B(D0→K-e+νe)=3.56(3)(9)%, and B(D+→ Kmacr 0e+νe)=8.53(13)(23)%, where the first error is statistical and the second systematic. In addition, form factors are studied through fits to the partial branching fractions obtained in five q2 ranges. By combining our results with recent unquenched lattice calculations, we obtain |Vcd|=0.217(9)(4)(23) and |Vcs|=1.015(10)(11)(106), where the final error is theoretical.

A Proposed Theoretical Model Using the Work of Thomas Kuhn, David Ausubel, and Mauritz Johnson as a Basis for Curriculum and Instruction Decisions in Science Education.

ERIC Educational Resources Information Center

Bowen, Barbara Lynn

This study presents a holistic framework which can be used as a basis for decision-making at various points in the curriculum-instruction development process as described by Johnson in a work published in 1967. The proposed framework has conceptual bases in the work of Thomas S. Kuhn and David P. Ausubel and utilizes the work of several perceptual…

Dual Production Sources in the Procurement of Weapon Systems: A Policy Analysis

DTIC Science & Technology

1983-11-01

Competitive Aspects of the AIM-9B Seeker Assembly Procurement, memorandum to Carl Wilbourn , U.S. Navy OP-96D, December 16, 1977. 3 sARINC Report, p...Corporation, R-2706-DR&E, February 1981. Carroll, Frank, Competitive Aspects of the AIM-9B Seeker Assembly Procurement, Memorandum to Carl Wilbourn , U.S...David J., and Joseph P. Large, Estimated Costs of Extended Low Rate Airframe Production, The Rand Corporation, R-2243-AF, March 1978, Fisher, Gene H

Radionuclide migration: laboratory experiments with isolated fractures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rundberg, R.S.; Thompson, J.L.; Maestas, S.

Laboratory experiments examining flow and element migration in rocks containing isolated fractures have been initiated at the Los Alamos National Laboratory. Techniques are being developed to establish simple fracture flow systems which are appropriate to models using analytical solutions to the matrix diffusion-flow equations, such as those of I. Neretnieks [I. Neretnieks, Diffusion in the Rock Matrix: An Important Factor in Radionuclide Retardation? J. Geophys. Res. 85, 4379 (1980).] These experiments are intended to be intermediate steps toward larger scale field experiments where it may become more difficult to establish and control the parameters important to nuclide migration in fracturedmore » media. Laboratory experiments have been run on fractures ranging in size from 1 to 20 cm in length. The hydraulic flow in these fractures was studied to provide the effective apertures. The flows established in these fracture systems are similar to those in the granite fracture flow experiments of Witherspoon et al. [P.A. Witherspoon, J.S.Y. Wang, K. Iwai, and J.E. Gale, Validity of Cubic Law for Fluid Flow in a Deformable Rock Fracture, Lawrence Berkeley Laboratory report LBL-9557 (October 1979).] Traced solutions containing {sup 85}Sr and {sup 137}Cs were flowed through fractures in Climax Stock granite and welded tuff (Bullfrog and Tram members, Yucca Mountain, Nevada Test Site). The results of the elutions through granite agree with the matrix diffusion calculations based on independent measurements of K/sub d/. The results of the elutions through tuff, however, agree only if the K/sub d/ values used in the calculations are lower than the K/sub d/ values measured using a batch technique. This trend has been previously observed in chromatographic column experiments with tuff. 5 figures, 3 tables.« less

Oral immunization with a novel attenuated Salmonella Typhimurium encoding influenza HA, M2e and NA antigens protects chickens against H7N9 infection.

PubMed

Kim, Je Hyoung; Hajam, Irshad Ahmed; Lee, John Hwa

2018-02-01

Attenuated Salmonella strains constitute a promising technology for the development of efficient protein-based influenza vaccines. H7N9, a low pathogenic avian influenza (LPAI) virus, is a major public health concern and currently there are no effective vaccines against this subtype. Herein, we constructed a novel attenuated Salmonella Typhimurium strain for the delivery and expression of H7N9 hemagglutinin (HA), neuraminidase (NA) or the conserved extracellular domain of the matrix protein 2 (M2e). We demonstrated that the constructed Salmonella strains exhibited efficient HA, NA and M2e expressions, respectively, and the constructs were safe and immunogenic in chickens. Our results showed that chickens immunized once orally with Salmonella (Sal) mutants encoding HA (Sal-HA), M2e (Sal-M2e) or NA (Sal-NA), administered either alone or in combination, induced both antigen-specific humoral and cell mediated immune (CMI) responses, and protected chickens against the lethal H7N9 challenge. However, chickens immunized with Sal-HA+Sal-M2e+Sal-NA vaccine constructs exhibited efficient mucosal and CMI responses compared to the chickens that received only Sal-HA, Sal-M2e or Sal-M2e+Sal-NA vaccine. Further, chickens immunized with Sal-HA+Sal-M2e+Sal-NA constructs cleared H7N9 infection at a faster rate compared to the chickens that were vaccinated with Sal-HA, Sal-M2e or Sal-M2e+Sal-NA, as indicated by the reduced viral shedding in cloacal swabs of the immunized chickens. We conclude that this vaccination strategy, based on HA, M2e and NA, stimulated efficient induction of immune protection against the lethal H7N9 LPAI virus and, therefore, further studies are warranted to develop this approach as a potential prophylaxis against LPAI viruses affecting poultry birds.

Synthesis, theoretical studies and molecular docking of a novel chlorinated tetracyclic: (Z/E)-3-(1,8-dichloro-9,10-dihydro-9,10-ethanoanthracen-11-yl)acrylaldehyde

NASA Astrophysics Data System (ADS)

Sultan, Mujeeb A.; Almansour, Abdulrahman I.; Pillai, Renjith Raveendran; Kumar, Raju Suresh; Arumugam, Natarajan; Armaković, Stevan; Armaković, Sanja J.; Soliman, Saied M.

2017-12-01

(Z/E)-3-(1,8-Dichloro-9,10-dihydro-9,10-ethanoanthracen-11-yl)acrylaldehyde 2 has been investigated experimentally and theoretically. The Wittig reaction of 1,8-dichloro-9,10-dihydro-9,10-ethanoanthracene-11-carbaldehyde 1 and (triphenylphosphoranylidene) acetaldehyde in toluene under reflux conditions resulted in compound 2. Spectroscopic characterization of compound 2 was performed by the Fourier-transform infrared spectroscopy, nuclear magnetic resonance, and high-resolution mass spectroscopy techniques. Density functional theory (DFT) calculations were conducted to study various global and local reactive properties. The spectra were also obtained by DFT calculations and corresponding comparisons were performed to validate the level of theory. Using DFT calculations, reactivity has been studied based on frontier molecular orbitals, charge distribution, average local ionization energies, Fukui functions, and bond dissociation energies for hydrogen abstraction. Molecular dynamics simulations have been used to investigate the influence of water as a solvent for compound 2. Finally, compound 2 was docked into the central and allosteric binding sites of the serotonin transporter enzyme and was found to be a good candidate as an antidepressant-like compound.

Generating Lookup Tables from the AE9/AP9 Models

DTIC Science & Technology

2015-06-16

AP9 Models 5a. CONTRACT NUMBER FA8802-14-C-0001 5b. GRANT NUMBER na 5c. PROGRAM ELEMENT NUMBER 5811 6. AUTHOR( S ) Joshua P. Davis 5d. PROJECT...NUMBER 11 5e. TASK NUMBER na 5f. WORK UNIT NUMBER na 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) The Aerospace Corporation 2310 E. El...Segundo Blvd. El Segundo, CA 90245-4609 8. PERFORMING ORGANIZATION REPORT NUMBER TOR-2015-00893 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS

Ada Compiler Validation Summary Report: Certificate Number: 940325S1. 11352 DDC-I DACS Sun SPARC/Solaries to Pentium PM Bare Ada Cross Compiler System, Version 4.6.4 Sun SPARCclassic = Intel Pentium (Operated as Bare Machine) Based in Xpress Desktop (Intel Product Number: XBASE6E4F-B)

DTIC Science & Technology

1994-03-25

Technology Building 225, Room A266 Gait•--eburg, Maryland 20899 U.S.A. Ada Von Ogan~ztionAda Jointt Program Office De & Software David R . Basel...Standards and Technology Building 225, Room A266 Gaithersburg, Maryland 20899 U.S.A. azi Ada Joint Program office Directoz’,’Coputer & Softvare David R ...characters, a bar (" r ) is written in the 16th position and the rest of the characters ame not prined. "* The place of the definition, i.e.. a line

David S. Ginley | NREL

Science.gov Websites

is on the development of new nanomaterials for organic electronics and as biofilters etc. Dr are applying what they learn to improved devices, i.e. batteries, frequency agile electronics Society (ECS) Institute of Electrical and Electronics Engineers (IEEE) American Association for the

SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage

PubMed Central

Hong, Xuehui; Liu, Wenyu; Song, Ruipeng; Shah, Jamie J.; Feng, Xing; Tsang, Chi Kwan; Morgan, Katherine M.; Bunting, Samuel F.; Inuzuka, Hiroyuki; Zheng, X. F. Steven; Shen, Zhiyuan; Sabaawy, Hatem E.; Liu, LianXin; Pine, Sharon R.

2016-01-01

SOX9 encodes a transcription factor that governs cell fate specification throughout development and tissue homeostasis. Elevated SOX9 is implicated in the genesis and progression of human tumors by increasing cell proliferation and epithelial-mesenchymal transition. We found that in response to UV irradiation or genotoxic chemotherapeutics, SOX9 is actively degraded in various cancer types and in normal epithelial cells, through a pathway independent of p53, ATM, ATR and DNA-PK. SOX9 is phosphorylated by GSK3β, facilitating the binding of SOX9 to the F-box protein FBW7α, an E3 ligase that functions in the DNA damage response pathway. The binding of FBW7α to the SOX9 K2 domain at T236-T240 targets SOX9 for subsequent ubiquitination and proteasomal destruction. Exogenous overexpression of SOX9 after genotoxic stress increases cell survival. Our findings reveal a novel regulatory mechanism for SOX9 stability and uncover a unique function of SOX9 in the cellular response to DNA damage. This new mechanism underlying a FBW7-SOX9 axis in cancer could have implications in therapy resistance. PMID:27566146

Neurale Netwerken en Radarsystemen (Neural Networks and Radar Systems)

DTIC Science & Technology

1989-08-01

general issues in cognitive science", Parallel distributed processing, Vol 1: Foundations, Rumelhart et al. 1986 pp 110-146 THO rapport Pagina 151 36 D.E...34Neural networks (part 2)",Expert Focus, IEEE Expert, Spring 1988. 61 J.A. Anderson, " Cognitive and Psychological Computations with Neural Models", IEEE...Pagina 154 69 David H. Ackley, Geoffrey E. Hinton and Terrence J. Sejnowski, "A Learning Algorithm for Boltzmann machines", cognitive science 9, 147-169

Research on Fire-Resistant Diesel Fuel Flammability Mitigation Mechanisms

DTIC Science & Technology

1982-12-01

Naegeli U.S. Army Fuels and Lubricants Research Laboratory Southwest Research Institute San Antonio, Texas Under Contract to U.S. Army Mobility Equipment...David Naegeli DAAK70-80-C-0001 DAAK70-82-C-0001 9. PERFORMING ORGANIZATION NAME AND ADDRESSES 10. PROGRAM ELEMENT, PROJECT. TASK U.S. Army Fuels and...water-containing diesel fuel blends. 43 VI. LIST OF REFERENCES 1. Weatherford, W.D., Jr., Fodor, G.E., Naegeli , D.W., Wright, B.R., Owens, E.C., and

Genetic Manipulation of the COP9 Signalosome Subunit PfCsnE Leads to the Discovery of Pestaloficins in Pestalotiopsis fici.

PubMed

Zheng, Yanjing; Ma, Ke; Lyu, Haining; Huang, Ying; Liu, Hongwei; Liu, Ling; Che, Yongsheng; Liu, Xingzhong; Zou, Huixi; Yin, Wen-Bing

2017-09-01

By deleting the COP9 signalosome subunit PfcsnE from Pestalotiopsis fici, seven compounds that were newly produced by the mutant could be characterized, including five new structures, pestaloficins A-E (1 and 3-6). Pestaloficin A (1) represents a new type of dimeric cyclohexanone derivative linked through an unprecedented pentacyclic spiral ring.

Improved synthesis of (3E,6Z,9Z)-1,3,6,9-nonadecatetraene, attraction inhibitor of bruce spanworm, Operophtera bruceata, to pheromone traps for monitoring winter moth, Operophtera brumata.

PubMed

Khrimian, Ashot; Lance, David R; Mastro, Victor C; Elkinton, Joseph S

2010-02-10

The winter moth, Operophtera brumata (Lepidoptera: Geometridae), is an early-season defoliator that attacks a wide variety of hardwoods and, in some cases, conifers. The insect is native to Europe but has become established in at least three areas of North America including southeastern New England. The female-produced sex attractant pheromone of the winter moth was identified as (3Z,6Z,9Z)-1,3,6,9-nonadecatetraene (1), which also attracts a native congener, the Bruce spanworm, Operophtera bruceata . Dissection, or (for certainty) DNA molecular testing, is required to differentiate between males of the two species. Thus, a trapping method that is selective for winter moth would be desirable. A geometric isomer of the pheromone, (3E,6Z,9Z)-1,3,6,9-nonadecatetraene (2), can reportedly inhibit attraction of Bruce spanworm to traps without affecting winter moth catch, but use of the pheromone and inhibitor together has not been optimized, nor has the synthesis of the inhibitor. This paper presents two new syntheses of the inhibitor (3E,6Z,9Z)-1,3,6,9-nonadecatetraene based on the intermediate (3Z,6Z)-3,6-hexadecadien-1-ol (4), which has also been utilized in the synthesis of the pheromone. The syntheses combine traditional acetylenic chemistry and Wittig olefination reactions. In one approach, 2 was synthesized in 80% purity (20% being pheromone 1), and in the second, tetraene 2 of 96% purity (and free of 1) was produced in 25% overall yield from dienol 4. The last method benefitted from a refined TEMPO-mediated PhI(OAc)(2) oxidation of 4 and a two-carbon homologation of the corresponding aldehyde 7.

jsc2018e051938

NASA Image and Video Library

2018-05-31

jsc2018e051938 - In the Integration Facility at the Baikonur Cosmodrome in Kazakhstan, the Expedition 56 prime and backup crewmembers pose for pictures May 31 with a soccer ball in front of the Soyuz booster rocket three of them will ride into space on June 6. The soccer ball and the booster bear the insignia of the FIFA World Cup soccer matches that will begin in mid-June throughout Russia. From left to right are the backup crewmembers, Anne McClain of NASA, Oleg Kononenko of Roscosmos and David Saint-Jacques of the Canadian Space Agency, and the prime crew, Serena Aunon-Chancellor of NASA, Sergey Prokopyev of Roscosmos and Alexander Gerst of the European Space Agency, who will launch June 6 in the Soyuz MS-09 spacecraft for a six-month mission on the International Space Station. ..Andrey Shelepin/Gagarin Cosmonaut Training Center.

Validation of the Patient Health Questionnaire-9 (PHQ-9) For Depression Screening in Adults with Epilepsy

PubMed Central

Rathore, Jaivir S.; Jehi, Lara E.; Fan, Youran; Patel, Sima I.; Foldvary-Schaefer, Nancy; Ramirez, Maya J.; Busch, Robyn M.; Obuchowski, Nancy A.; Tesar, George E.

2015-01-01

Objective Assess accuracy and operating characteristics of the Patient Health Questionnaire-9 (PHQ-9) for depression-screening in adults with epilepsy. Methods Tertiary epilepsy center patients served as the study population with 237 agreeing to structured interview using the Mini-International Neuropsychiatric Interview (MINI), a “gold standard” instrument developed for rapid diagnosis of neuropsychiatric disorders, including major depressive disorder (MDD); 172 also completed the PHQ-9, and 127 completed both the PHQ-9 and the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) within two days of the MINI. Sensitivity, specificity, positive & negative predictive values & areas under the ROC curves for each instrument were determined. Cut-points of 10 for the PHQ-9 and 15 for the NDDI-E were used and ratings at or above the cut-points were considered screen-positive. The PHQ-9 was divided into cognitive/affective (PHQ-9/CA) and somatic (PHQ-9/S) subscales to determine comparative depression-screening accuracy. Results The calculated areas under the ROC curves for the PHQ-9 (n=172) and the PHQ-9/CA and PHQ-9/S sub-scales were 0.914, 0.924, and 0.846, respectively, with the PHQ-9 more accurate than the PHQ-9/S (p=0.002) but no different than the PHQ-9/CA (p=0.378). At cut-points of 10 and 15, respectively, the PHQ-9 had higher sensitivity (0.92 vs 0.87), but lower specificity (0.74 vs 0.89) than the NDDI-E. The areas under the ROC curves of the PHQ-9 and the NDDI-E showed similar accuracy (n=127; 0.930 vs 0.934; p=0.864). Significance The PHQ-9 is an efficient & non-proprietary depression screening instrument with excellent accuracy validated for use in adult epilepsy patients as well as multiple other medical populations. PMID:25064739

Correction to: Extreme Precipitation, Public Health Emergencies, and Safe Drinking Water in the USA.

PubMed

Exum, Natalie G; Betanzo, Elin; Schwab, Kellogg J; Chen, Thomas Y J; Guikema, Seth; Harvey, David E

2018-06-01

Unfortunately, the original publication of this article contained mistakes. The publisher introduced an error after proofreading where the name of the co-author was mistakenly captured as "David P. E. Harvey". The correct name should be "David E. Harvey".

Toward Managing & Automating CyberCIEGE Scenario Definition File Creation

DTIC Science & Technology

2004-03-01

Deitel , H & Deitel , P. (2002). Java: How to Program fourth Ed. New Jersey: Prentice Hall. [Fisher 2003] Fisher, C., Chiricosta, T. & Witherspoon, T...experience with the Java programming language. Precious time was required to learn how to implement some of the more complicated interface components...demonstrating the risks of the Internet and open networks [Irvine1 2003]. Policy is subtle, and there is no easy way to demonstrate how one small change

Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice.

PubMed

Zhou, Qiong; Wang, Man; Du, Ying; Zhang, Wei; Bai, Miao; Zhang, Zhuo; Li, Zhuyi; Miao, Jianting

2015-04-01

Growing evidence indicates that the activation of c-Jun N-terminal kinase (JNK) is implicated in the multiple major pathological features of Alzheimer disease (AD). However, whether specific inhibition of JNK activation could prevent disease progression in adult transgenic AD models at moderate stage remains unknown. Here we first investigated the potential disease-modifying therapeutic effect of systemic administration of SP600125, a small-molecule JNK-specific inhibitor, in middle-aged APPswe/PS1dE9 mice. Using behavioral, histological, and biochemical methods, outcomes of SP600125 treatment on neuropathology and cognitive deficits were studied in APPswe/PS1dE9 mice. Compared with vehicle-treated APPswe/PS1dE9 mice, chronic treatment of SP600125 for 12 weeks potently inhibited JNK activation, which resulted in a marked improvement of behavioral measures of cognitive deficits and a dramatic reduction in amyloid plaque burden, β-amyloid production, tau hyperphosphorylation, inflammatory responses, and synaptic loss in these transgenic animals. In particular, we found that SP600125 treatment strongly promoted nonamyloidogenic amyloid precursor protein (APP) processing and inhibited amyloidogenic APP processing via regulating APP-cleavage secretase expression (ie, ADAM10, BACE1, and PS1) in APPswe/PS1dE9 mice. Our findings demonstrate that chronic SP600125 treatment is powerfully effective in slowing down disease progression by markedly reducing multiple pathological features and ameliorating cognitive deficits associated with AD. This study highlights the concept that active JNK actually contributes to the development of the disease, and provides critical preclinical evidence that specific inhibition of JNK activation by SP600125 treatment may be a novel promising disease-modifying therapeutic strategy for the treatment of AD. © 2015 American Neurological Association.

Identification of a molecular recognition feature in the E1A oncoprotein that binds the SUMO conjugase UBC9 and likely interferes with polySUMOylation.

PubMed

Yousef, A F; Fonseca, G J; Pelka, P; Ablack, J N G; Walsh, C; Dick, F A; Bazett-Jones, D P; Shaw, G S; Mymryk, J S

2010-08-19

Hub proteins have central roles in regulating cellular processes. By targeting a single cellular hub, a viral oncogene may gain control over an entire module in the cellular interaction network that is potentially comprised of hundreds of proteins. The adenovirus E1A oncoprotein is a viral hub that interacts with many cellular hub proteins by short linear motifs/molecular recognition features (MoRFs). These interactions transform the architecture of the cellular protein interaction network and virtually reprogram the cell. To identify additional MoRFs within E1A, we screened portions of E1A for their ability to activate yeast pseudohyphal growth or differentiation. This identified a novel functional region within E1A conserved region 2 comprised of the sequence EVIDLT. This MoRF is necessary and sufficient to bind the N-terminal region of the SUMO conjugase UBC9, which also interacts with SUMO noncovalently and is involved in polySUMOylation. Our results suggest that E1A interferes with polySUMOylation, but not with monoSUMOylation. These data provide the first insight into the consequences of the interaction of E1A with UBC9, which was initially described in 1996. We further demonstrate that polySUMOylation regulates pseudohyphal growth and promyelocytic leukemia body reorganization by E1A. In conclusion, the interaction of the E1A oncogene with UBC9 mimics the normal binding between SUMO and UBC9 and represents a novel mechanism to modulate polySUMOylation.

9-Hydroxyprostaglandin dehydrogenase in rat kidney cortex converts prostaglandin I2 into 15-keto-13,14-dihydro 6-ketoprostaglandin E1.

PubMed

Pace-Asciak, C R; Domazet, Z

1984-11-14

15-Keto-13,14-dihydro 6-ketoprostaglandin E1 was positively identified by gas chromatography-mass spectrometry with negative-ion chemical ionisation detection from samples of rat kidney high-speed supernatant incubated with prostaglandin I2 in the presence of NAD+. A decreased formation of this product was observed when NAD+ was substituted with NADP+ and none was observed in the absence of nucleotide or substrate prostaglandin I2. Experiments with [9 beta-3H]prostaglandin I2 showed a time- and concentration-dependent loss of tritium which appeared as tritiated water, typical of reaction of [9 beta-3H]prostaglandin substrates with the enzyme, 9-hydroxyprostaglandin dehydrogenase. Time-course measurements of the appearance of tritiated water showed similar rates with 6-keto[9 beta-3H]prostaglandin F1 alpha and 15-keto-13,14-dihydro 6-keto[9 beta-3H]prostaglandin F1 alpha as substrates. These experiments suggest that the transformation of prostaglandin I2 and 6-ketoprostaglandin F1 alpha into the 15-keto-13,14-dihydro 6-ketoprostaglandin E1 catabolite occurs in this in vitro preparation via the corresponding 15-keto-13,14-dihydro catabolite of 6-ketoprostaglandin F1 alpha.

The Ghost in the Atom

NASA Astrophysics Data System (ADS)

Davies, P. C. W.; Brown, Julian R.

1993-09-01

Foreword; 1. The strange world of the quantum; 2. Alain Aspect; 3. John Bell; 4. John Wheeler; 5. Rudolf Peierls; 6. David Deutsch; 7. John Taylor; 8. David Bohm; 9. Basil Hiley; Glossary; Further reading; Index.

Ultrasound-guided microinjection into the mouse forebrain in utero at E9.5.

PubMed

Pierfelice, Tarran J; Gaiano, Nicholas

2010-11-13

In utero survival surgery in mice permits the molecular manipulation of gene expression during development. However, because the uterine wall is opaque during early embryogenesis, the ability to target specific parts of the embryo for microinjection is greatly limited. Fortunately, high-frequency ultrasound imaging permits the generation of images that can be used in real time to guide a microinjection needle into the embryonic region of interest. Here we describe the use of such imaging to guide the injection of retroviral vectors into the ventricular system of the mouse forebrain at embryonic day (E) 9.5. This method uses a laparotomy to permit access to the uterine horns, and a specially designed plate that permits host embryos to be bathed in saline while they are imaged and injected. Successful surgeries often result in most or all of the injected embryos surviving to any subsequent time point of interest (embryonically or postnatally). The principles described here can be used with slight modifications to perform injections into the amnionic fluid of E8.5 embryos (thereby permitting infection along the anterior posterior extent of the neural tube, which has not yet closed), or into the ventricular system of the brain at E10.5/11.5. Furthermore, at mid-neurogenic ages (~E13.5), ultrasound imaging can be used direct injection into specific brain regions for viral infection or cell transplantation. The use of ultrasound imaging to guide in utero injections in mice is a very powerful technique that permits the molecular and cellular manipulation of mouse embryos in ways that would otherwise be exceptionally difficult if not impossible.

A Constructive Induction Approach to Computer Immunology

DTIC Science & Technology

1999-03-01

LVM98] Lamont, Gary B., David A. Van Veldhuizen , and Robert E Marmelstein, A Distributed Architecture for a Self-Adaptive Computer Virus...Artificial Intelligence, Herndon, VA, 1995. [MVL98] Marmelstein, Robert E., David A. Van Veldhuizen , and Gary B. Lamont. Modeling & Analysis

KSC-2011-1310

NASA Image and Video Library

2011-01-29

CAPE CANAVERAL, Fla. -- Command module pilot of Apollo 9 and commander of Apollo 15 David Scott talks to attendees of the Apollo 14 Anniversary Soirée at the Kennedy Space Center Visitor Complex's Saturn V Center. The celebration was hosted by the Astronaut Scholarship Foundation. Apollo 14 landed on the lunar surface 40 years ago on Feb. 5, 1971. Photo credit: NASA/Kim Shiflett

KSC-2011-1314

NASA Image and Video Library

2011-01-29

CAPE CANAVERAL, Fla. -- Command module pilot of Apollo 9 and commander of Apollo 15 David Scott talks to attendees of the Apollo 14 Anniversary Soirée at the Kennedy Space Center Visitor Complex's Saturn V Center. The celebration was hosted by the Astronaut Scholarship Foundation. Apollo 14 landed on the lunar surface 40 years ago on Feb. 5, 1971. Photo credit: NASA/Kim Shiflett

Effect of resveratrol on 17beta-estradiol sulfation by human hepatic and jejunal S9 and recombinant sulfotransferase 1E1.

PubMed

Furimsky, Anna M; Green, Carol E; Sharp, Lewanne E Hunt; Catz, Paul; Adjei, Araba A; Parman, Toufan; Kapetanovic, Izet M; Weinshilboum, Richard M; Iyer, Lalitha V

2008-01-01

The purpose of this study was to investigate the sulfation of resveratrol (3,5,4'-trihydroxystilbene) and its potential to exhibit drug-drug interactions via sulfation. The possible interaction of resveratrol with 17beta-estradiol (E2), a major estrogen hormone and prototypic substrate for sulfate conjugation, was studied. Resveratrol and E2 are both known to undergo sulfate conjugation catalyzed by human sulfotransferases (SULTs). Resveratrol is a phytoestrogen with mixed estrogen agonist/antagonist properties that is being developed as a chemopreventive agent. The sulfate conjugation of E2 and resveratrol were studied individually using S9 fractions from human liver and jejunum as well as recombinant human SULT isoforms. The sulfation of E2 (3-20 nM) was then investigated in the presence of various concentrations (0, 0.5, 1, and 2 microM) of resveratrol using the two S9 preparations as well as recombinant SULT1E1, the major isoform responsible for E2 sulfation. Resveratrol inhibited E2 sulfation with estimated K(i) values of 1.1 microM (liver), 0.6 microM (jejunum), and 2.3 microM (SULT1E1), concentrations that could be pharmacologically relevant. The results suggest that these phytoestrogens can potentially alter the homeostasis of estrogen levels. These findings also imply that resveratrol may inhibit the metabolism of other estrogen analogs or therapeutic agents such as ethinylestradiol or dietary components that are also substrates for SULT1E1.

Humans, Animals and the World We Inhabit--On and beyond the Symposium "Second Nature, 'Bildung' and McDowell: David Bakhurst's 'The Formation of Reason'"

ERIC Educational Resources Information Center

Misawa, Koichiro

2017-01-01

David Bakhurst's 2011 book "The Formation of Reason" explores the philosophy of John McDowell in general and the Aristotelian notion of second nature more specifically, topics to which philosophers of education have not yet given adequate attention. The book's widespread appeal led to the symposium "Second Nature, Bildung and…

David J. Triggle: Medicinal chemistry, to pharmacology, calcium channels, and beyond.

PubMed

Walker, Michael J A

2015-11-15

David Triggle's scientific career began as a chemist, went through medicinal chemistry into pharmacology, and finally on to somewhat more philosophical interests in later years. It was a career marked by many contributions to all of those aspects of science. Chief amongst his many contributions, in addition to those in medicinal chemistry, was his work on the drugs known as calcium ion channel blockers or (calcium antagonists). In the calcium ion channel field he was a particularly instrumental figure in sorting out the mechanisms, actions and roles of the class of calcium channel blockers, known chemical and pharmacologically as the dihydropyridines (DHPs) in particular, as well as other calcium blockers of diverse structures. During the course of a long career, and extensive journeys into medicinal chemistry and pharmacology, he published voluminously in terms of papers, reviews, conference proceedings and books. Notably, many of his papers often had limited authorship where, as senior author it reflected his deep involvement in all aspects of the reported work. His work always helped clarify the field while his incisive reviews, together with his role in coordinating and running scientific meetings, were a great help in clarifying and organizing various fields of study. He has had a long and illustrious career, and is wellknown in the world of biomedical science; his contributions are appreciated, and well recognized everywhere. The following article attempts to chart a path through his work and contributions to medicinal chemistry, pharmacology, science, academia and students. Copyright © 2015 Elsevier Inc. All rights reserved.

Increased Th9 cells and IL-9 levels accelerate disease progression in experimental atherosclerosis.

PubMed

Li, Qing; Ming, Tingting; Wang, Yuanmin; Ding, Shaowei; Hu, Chaojie; Zhang, Cuiping; Cao, Qi; Wang, Yiping

2017-01-01

Atherosclerosis (AS) is the number one killer in developed countries, and currently considered a chronic inflammatory disease. The central role of T cells in the pathogenesis of atherosclerosis is well documented. However, little is known about the newly described T cell subset-Th9 cells and their role in AS pathogenesis. Here, the amounts of Th9 cells as well as their key transcription factors and relevant cytokines during atherosclerosis were assessed in ApoE -/- mice and age-matched C57BL/6J mice. Significantly increased Th9 cell number, Th9 related cytokine (IL-9), and key transcription factor (PU.1) were found in ApoE -/- mice compared with age-matched C57BL/6J mice. Additionally, treatment with rIL-9 accelerated atherosclerotic development, which was attenuated by anti-IL-9 antibodies. These data suggested that both Th9 cells and related IL-9 play key roles in the pathogenesis of atherosclerosis, and antibodies against these antigens offer a novel therapeutic approach in AS treatment.

[David H. Hubel, Torsten N. Wiesel, Nigel W. Daw: the creators of modern visual neurophysiology].

PubMed

Czepita, D

1999-01-01

Curriculum vitae as well as scientifical out-put of the Nobel Price winners--David Hunter Hubel and Torsten Nils Wiesel, and the Friedenwald Memorial Award laureate--Nigel Warwick Daw are described. D.H. Hubel was born in 1926 in Windsor, Canada. In 1951 he received a medical degree from McGill University. From 1955-1958 he worked at Walter Reed Army Institute of Research, from 1958-1959 at Johns Hopkins University, and since 1959 at Harvard University. T.N. Wiesel was born in 1924 in Uppsala, Sweden. In 1954 he received a medical degree from Karolinska Institute. From 1955-1959 he worked at Johns Hopkins University, from 1959-1982 at Harvard University, and since 1983 at the Rockefeller University, New York. N.W. Daw was born in 1933 in London, England. In 1961 he received a bachelor's degree in mathematics from Trinity College. In 1967 he became a doctor of philosophy in biophysics at Johns Hopkins University. From 1967-1969 he worked at Harvard University, from 1969-1992 at Washington University, and since 1992 at Yale University.

Hill Street Blues Post Conflict: Host Nation Police Advisor

DTIC Science & Technology

2013-05-23

24. 9Ann Marlowe , “David Galula: His Life and Intellectual Context” (Monograph, U.S. War College, 2010). 4...Counterinsurgency: Lessons From Iraq. Norfolk, VA.: National Defense University. Marlowe , A. "David Galula: His Life and Intellectual Context." Monograph

A philosophical analysis of David Orr's theory of ecological literacy: biophilia, ecojustice and moral education in school learning communities

NASA Astrophysics Data System (ADS)

Mitchell, Debra B.; Mueller, Michael P.

2011-03-01

In his writings, David Orr claims that the US is in an "ecological crisis" and that this stems from a crisis of education. He outlines a theory of ecological literacy, a mode by which we better learn the ecology of the Earth and live in a sustainable manner. While emphasizing a shock doctrine, the diagnosis of "crisis" may be correct, but it is short-lived for children and adults of the world. In this philosophical analysis of Orr's theory, it is argued that we move beyond the perspective of crisis. By extending Orr's ecological literacy with biophilia and ecojustice and by recognizing the importance of experience-in-learning, science education is envisioned to incorporate values and morals within a longer term ideology of educational reform.

(E)-2-Meth-oxy-9-(2-meth-oxy-9H-xanthen-9-yl-idene)-9H-xanthene.

PubMed

Tian, Xiang-Yu; Song, Qin-Hua

2013-01-01

The title compound, C28H20O4, was synthesized by a bimolecular Zn-HCl reduction in glacial acetic acid using the meth-oxy-substituted xanthone as a starting material. The crystal structure shows that the 2,2'-meth-oxy-bixanthenyl-idene unit is an E-type conformation anti-folded conformer. The mol-ecule lies on an inversion center. The meth-oxy group is almost coplanar with the attached benzene ring, with a C-O-C-C torsion angle of 179.38 (14)°.

Prevalence of HIV, syphilis, and other sexually transmitted infections among MSM from three cities in Panama.

PubMed

Hakre, Shilpa; Arteaga, Griselda B; Núñez, Aurelio E; Arambu, Nelson; Aumakhan, Bulbulgul; Liu, Michelle; Peel, Sheila A; Pascale, Juan M; Scott, Paul T

2014-08-01

Respondent-driven sampling (RDS) was used to conduct a biobehavioral survey among men who have sex with men (MSM) in three cities in the Republic of Panama. We estimated the prevalence of HIV, syphilis, and other sexually transmitted infections (STIs), sociodemographic characteristics, and sexual risk behaviors. Among 603 MSM recruited, RDS-adjusted seroprevalences (95 % confidence intervals) were: HIV-David 6.6 % (2.2-11.4 %), Panama 29.4 % (19.7-39.7 %), and Colon 32.6 % (18.0-47.8 %); active syphilis-David 16.0 % (8.9-24.2 %), Panama 24.7 % (16.7-32.9 %), Colon 31.6 % (14.8-47.5 %); resolved HBV infection-David 10.0 % (4.8-16.8 %), Panama 29.4 % (20.0-38.3 %), and Colon 40.6 % (21.9-54.4 %); herpes simplex virus type 2-David 38.4 % (27.9-48.9 %), Panama 62.6 % (52.8-71.0 %), and Colon 72.9 % (57.4-85.8 %). At least a third of MSM in each city self-identified as heterosexual or bisexual. HIV prevalence is concentrated among MSM. Preventive interventions should focus on increasing HIV and syphilis testing, and increasing promotion of condom awareness and use.

Water Operations Technical Support Program: Proceedings of the Seminar on Water Quality (9th) Held in San Antonio, Texas on 16-20 March 1992

DTIC Science & Technology

1992-10-01

System Model for Water Quality Control by Jackson K. Brown ...................................... 119 Management Technique for Long-Term Flow... Modeling Activities for the ARCS Program by David C. Cowgill ...................................... 141 Toxicity and Chemistry Testing of Great Lakes...225 Combined Hydrodynamic and Water Quality Modeling of Lower Green Bay by David J. Mark, Barry W. Bunch, and Norman W. Scheffner

Hedonic Price Indices for Ground Vehicles

DTIC Science & Technology

2015-05-01

I N S T I T U T E F O R D E F E N S E A N A L Y S E S Hedonic Price Indices for Ground Vehicles David M. Tate INSTITUTE FOR DEFENSE ANALYSES 4850... Hedonic Price Indices for Ground Vehicles David M. Tate Institute for Defense Analyses (CARD) 4850 Mark Center Dr., Alexandria, VA 22311 Ph...4 1. Basic Hedonic Regression

Revisiting the 1981 Nobel Prize to Roger Sperry, David Hubel, and Torsten Wiesel on the occasion of the centennial of the Prize to Golgi and Cajal.

PubMed

Berlucchi, Giovanni

2006-12-01

In 1981 the Nobel Prize for Medicine or Physiology was awarded to Roger Sperry for his work on the functional specialization of the cerebral hemispheres, and to David Hubel and Torsten Wiesel for their work on information processing in the visual system. The present paper points to some important links between the work of Sperry and that of Hubel and Wiesel and to their influences on neuroscience in the best tradition going back to Cajal.

Rapid and Efficient Conversion of All-E-astaxanthin to 9Z- and 13Z-Isomers and Assessment of Their Stability and Antioxidant Activities.

PubMed

Yang, Cheng; Zhang, Lianfu; Zhang, Hua; Sun, Qingrui; Liu, Ronghua; Li, Jing; Wu, Leiyan; Tsao, Rong

2017-02-01

An optimized isomerization method was developed by heating all-E-astaxanthin in ethyl acetate (70 °C) with I-TiO 2 catalyst, yielding 22.7% and 16.9% of 9Z- and 13Z-astaxanthin, respectively, in 2 h, with 92-95% purity after semipreparative HPLC purification. 13Z-Astaxanthin had higher antioxidant activity than all-E- and 9Z-astaxanthins in oxygen radical absorbing capacity assay for lipophilic compounds, photochemiluminescence, and cellular antioxidant activity (CAA) assays, and 9Z-astaxanthin was higher in DPPH radical-scavenging activity assay and lower in CAA assay. All isomers were relatively stable between pH 2.0 and 11.6, except 13Z- and 9Z-astaxanthins at pH 2.0, suggesting they may be converted after passing the gastric phase in vivo. Metal ions did not significantly (p < 0.05) affect the stability. Results of the current study provides a means for further study into the mechanisms related to in vivo transformation and bioavailability of Z-astaxanthins, and their application in the development of functional foods and nutraceutical products.

Forgeting Lessons Learned: The United States Army’s Inability To Embrace Irregular Warfare

DTIC Science & Technology

2014-04-01

for future conflicts. This type of force and policy would become what David Fitzgerald would call the “Rumsfeld Doctrine” in his book Lessons...and political conditions. The writers of the manual were heavily influenced by early counterinsurgency practitioners as David Fitzgerald writes...134 8 Ibid, 134 9 Ibid,142 10 Ibid, 152 11 Ibid, 234 12 Ibid, 241 13 Ibid, 257 14 Ibid, 265 15 Fitzgerald , David. Learning to Forget: US

Regulation of IgE-Mediated Food Allergy by IL-9 Producing Mucosal Mast Cells and Type 2 Innate Lymphoid Cells.

PubMed

Lee, Jee-Boong

2016-08-01

Due to the increasing prevalence and number of life-threatening cases, food allergy has emerged as a major health concern. The classic immune response seen during food allergy is allergen-specific IgE sensitization and hypersensitivity reactions to foods occur in the effector phase with often severe and deleterious outcomes. Recent research has advanced understanding of the immunological mechanisms occurring during the effector phase of allergic reactions to ingested food. Therefore, this review will not only cover the mucosal immune system of the gastrointestinal tract and the immunological mechanisms underlying IgE-mediated food allergy, but will also introduce cells recently identified to have a role in the hypersensitivity reaction to food allergens. These include IL-9 producing mucosal mast cells (MMC9s) and type 2 innate lymphoid cells (ILC2s). The involvement of these cell types in potentiating the type 2 immune response and developing the anaphylactic response to food allergens will be discussed. In addition, it has become apparent that there is a collaboration between these cells that contributes to an individual's susceptibility to IgE-mediated food allergy.

Open Reading Frame E3-10.9K of Subspecies B1 Human Adenoviruses Encodes a Family of Late Orthologous Proteins That Vary in Their Predicted Structural Features and Subcellular Localization ▿

PubMed Central

Frietze, Kathryn M.; Campos, Samuel K.; Kajon, Adriana E.

2010-01-01

Subspecies B1 human adenoviruses (HAdV-B1s) are important causative agents of acute respiratory disease, but the molecular bases of their distinct pathobiology are still poorly understood. Marked differences in genetic content between HAdV-B1s and the well-characterized HAdV-Cs that may contribute to distinct pathogenic properties map to the E3 region. Between the highly conserved E3-19K and E3-10.4K/RIDα open reading frames (ORFs), and in the same location as the HAdV-C ADP/E3-11.6K ORF, HAdV-B1s carry ORFs E3-20.1K and E3-20.5K and a polymorphic third ORF, designated E3-10.9K, that varies in the size of its predicted product among HAdV-B1 serotypes and genomic variants. As an initial effort to define the function of the E3-10.9K ORF, we carried out a biochemical characterization of E3-10.9K-encoded orthologous proteins and investigated their expression in infected cells. Sequence-based predictions suggested that E3-10.9K orthologs with a hydrophobic domain are integral membrane proteins. Ectopically expressed, C-terminally tagged (with enhanced green fluorescent protein [EGFP]) E3-10.9K and E3-9K localized primarily to the plasma membrane, while E3-7.7K localized primarily to a juxtanuclear compartment that could not be identified. EGFP fusion proteins with a hydrophobic domain were N and O glycosylated. EGFP-tagged E3-4.8K, which lacked the hydrophobic domain, displayed diffuse cellular localization similar to that of the EGFP control. E3-10.9K transcripts from the major late promoter were detected at late time points postinfection. A C-terminally hemagglutinin-tagged version of E3-9K was detected by immunoprecipitation at late times postinfection in the membrane fraction of mutant virus-infected cells. These data suggest a role for ORF E3-10.9K-encoded proteins at late stages of HAdV-B1 replication, with potentially important functional implications for the documented ORF polymorphism. PMID:20739542

In Vivo Testing of Chemopreventive Agents Using the Dog Model of Spontaneous Prostate Carcinogenesis

DTIC Science & Technology

2003-03-01

Carcinogenesis 6. AUTHOR(S) David J. Waters, Ph.D., DVM 7. PERFORMING ORGANIZATION NAME (S) AND ADDRESS(ES) S. PERFORMING ORGANIZATION Purdue Research...Foundation REPORT NUMBER West Lafayette, IN 47907-1021 E-Mail: waters@vet .purdue .edu 9. SPONSORING / MONITORING 10. SPONSORING I MONITORING AGENCY NAME (S...commercial organizations and trade names in this report do not constitute an official Department of Army endorsement or approval of the products or services

Korzun and STS-112 crewmembers in the SM during Expedition Five on the ISS

NASA Image and Video Library

2002-10-09

ISS005-E-16542 (9 October 2002) --- Cosmonaut Valery G. Korzun, Expedition Five mission commander, and the STS-112 crewmembers were photographed in the Zvezda Service Module on the International Space Station (ISS). Others pictured are astronauts Jeffrey S. Ashby, STS-112 mission commander; Pamela A. Melroy, pilot; Sandra H. Magnus, Piers J. Sellers, David A. Wolf, and cosmonaut Fyodor N. Yurchikhin, all mission specialists. Korzun and Yurchikhin represent Rosaviakosmos.

Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice.

PubMed

Tsai-Teng, Tzeng; Chin-Chu, Chen; Li-Ya, Lee; Wan-Ping, Chen; Chung-Kuang, Lu; Chien-Chang, Shen; Chi-Ying, Huang F; Chien-Chih, Chen; Shiao, Young-Ji

2016-06-27

The fruiting body of Hericium erinaceus has been demonstrated to possess anti-dementia activity in mouse model of Alzheimer's disease and people with mild cognitive impairment. However, the therapeutic potential of Hericium erinaceus mycelia on Alzheimer's disease remains unclear. In this study, the effects of erinacine A-enriched Hericium erinaceus mycelia (HE-My) on the pathological changes in APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease are studied. After a 30 day oral administration to 5 month-old female APPswe/PS1dE9 transgenic mice, we found that HE-My and its ethanol extracts (HE-Et) attenuated cerebral Aβ plaque burden. It's worth noting that the attenuated portion of a plaque is the non-compact structure. The level of insulin-degrading enzyme was elevated by both HE-My and HE-Et in cerebral cortex. On the other hand, the number of plaque-activated microglia and astrocytes in cerebral cortex and hippocampus were diminished, the ratio of nerve growth factor (NGF) to NGF precursor (proNGF) was increased and hippocampal neurogenesis was promoted after these administrations. All the mentioned benefits of these administrations may therefore improve the declined activity of daily living skill in APPswe/PS1dE9 transgenic mice. These results highlight the therapeutic potential of HE-My and HE-Et on Alzheimer's disease. Therefore, the effective components of HE-My and HE-Et are worth to be developed to become a therapeutic drug for Alzheimer's disease.

Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells.

PubMed

Pihlaja, Rea; Takkinen, Jatta; Eskola, Olli; Vasara, Jenni; López-Picón, Francisco R; Haaparanta-Solin, Merja; Rinne, Juha O

2015-04-28

Recently, the role of monoacylglycerol lipase (MAGL) as the principal regulator of simultaneous prostaglandin synthesis and endocannabinoid receptor activation in the CNS was demonstrated. To expand upon previously published research in the field, we observed the effect of the MAGL inhibitor JZL184 during the early-stage proinflammatory response and formation of beta-amyloid (Aβ) in the Alzheimer's disease mouse model APdE9. We also investigated its effects in proinflammatory agent - induced astrocytes and microglia isolated from adult mice. Transgenic APdE9 mice (5 months old) were treated with JZL184 (40 mg/kg) or vehicle every day for 1 month. In vivo binding of the neuroinflammation-related, microglia-specific translocator protein (TSPO) targeting radioligand [(18) F]GE-180 decreased slightly but statistically non-significantly in multiple brain areas compared to vehicle-treated mice. JZL184 treatment induced a significant decrease in expression levels of inflammation-induced, Iba1-immunoreactive microglia in the hippocampus (P < 0.01) and temporal and parietal (P < 0.05) cortices. JZL184 also induced a marked decrease in total Aβ burden in the temporal (P < 0.001) and parietal (P < 0.01) cortices and, to some extent, in the hippocampus. Adult microglial and astrocyte cultures pre-treated with JZL184 and then exposed to the neuroinflammation-inducing agents lipopolysaccharide (LPS), interferon-gamma (IFN-γ), and Aβ42 had significantly reduced proinflammatory responses compared to cells without JZL184 treatment. JZL184 decreased the proinflammatory reactions of microglia and reduced the total Aβ burden and its precursors in the APdE9 mouse model. It also reduced the proinflammatory responses of microglia and astrocytes isolated from adult mice.

2012 ARPA-E Energy Innovation Summit: Profiling General Compression: A River of Wind

ScienceCinema

Marcus, David; Ingersoll, Eric

2018-05-30

The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. A few videos were selected for showing during the Summit to attendees. These 'performer videos' highlight innovative research that is ongoing and related to the main topics of the Summit's sessions. Featured in this video are David Marcus, Founder of General Compression, and Eric Ingersoll, CEO of General Compression. General Compression, with the help of ARPA-E funding, has created an advanced air compression process which can store and release more than a weeks worth of the energy generated by wind turbines.

Synthesis of 9,9,9-trideutero-1,4-dihydroxynonane mercapturic acid (d3-DHN-MA), a useful internal standard for DHN-MA urinalysis.

PubMed

Chantegrel, B; Deshayes, C; Doutheau, A; Steghens, J P

2002-10-01

Racemic 1,4-dihydroxynonane mercapturic acid (DHN-MA) and 9,9,9-trideutero-1,4-dihydroxynonane mercapturic acid (d3-DHN-MA) are synthesized on a 400-mg scale (overall yield approximately 40%) by a two-step sequence involving Michael addition of N-acetyl-L-cysteine to methyl 4-hydroxynon-2(E)-enoate or methyl 9,9,9-trideutero-4-hydroxynon-2 (E)-enoate, followed by reduction of the intermediate adducts with lithium borohydride. The requisite starting methyl esters are obtained, respectively, from heptanal or 7,7,7-trideuteroheptanal and methyl 4-chlorophenylsulfinylacetate via a sulfoxide piperidine and carbonyl reaction described in the literature. The 7,7,7-trideuteroheptanal is easily prepared by classical methods in four steps from 6-bromo-1-hexanol. 13C NMR data indicate that DHN-MA as well as d3-DHN-MA are obtained as mixtures of four diastereomers. Preliminary results show that d3-DHN-MA could be used as an internal standard for mass spectrometric quantification of DHN-MA in human urine.

Direct Methanol Fuel Cell Battery Replacement Program

DTIC Science & Technology

2011-04-11

Matthey PtRu in operating direct methanol fuel cells” Phys. Chem. Chem. Phys., 10, 6430-6437 (2008) 2. Harry Rivera, Jamie S. Lawton , David E. Budil and...Phys. Chem. B, 112, (29) 8542-8548 (2008) 3. Jamie S. Lawton , Eugene S. Smotkin and David E. Budil, “ESR Investigation of Microviscosity, Microscopic

Analyzing the United States Air Force Organizational Structure - A Case for Reorganization

DTIC Science & Technology

2011-05-16

professional staff manning. 159 David R. Segal and Mady Wechsler Segal, “Change in Military Organization”, Annual Review of Sociology, no. 9 (1983): 156...budget (accessed February 7, 2011). Segal, David R., and Segal, Mady Wechsler . Change in Military Organization. Annual Review of Sociology, Vol. 9 (1983...workforce. This does not include the intelligence organizations.” 91 Air Force Personnel Center, “Air Force Strength from 1948 thru 2010,” http://w11

Reusable Software Component Retrieval via Normalized Algebraic Specifications

DTIC Science & Technology

1991-12-01

outputs. In fact, this method of query is simpler for matching since it relieves the system from the burden of generating a test set. Eichmann [Eich9l...September 1991. [Eich9l] Eichmann , David A., "Selecting Reusable Components Using Algebraic Specifications", Proceedings of the Second International...Technology Atlanta, Georgia 30332-0800 12. Dr. David Eichmann 1 Department of Statistics and Computer Science Knapp Hall West Virginia University Morgantown, West Virginia 26506 226

Development of a Robust Static Punch Experiment for Screening Unprocessed Ultra-High Molecular Weight Polyethylene (UHMWPE) Unidirectional Cross-Ply Material

DTIC Science & Technology

2014-09-01

Cross-Ply Material by David Gray, Robert Kaste , and Paul Moy ARL-TR-7090 September 2014...Screening Unprocessed Ultra-High Molecular Weight Polyethylene (UHMWPE) Unidirectional Cross-Ply Material David Gray, Robert Kaste , and Paul...ELEMENT NUMBER 6. AUTHOR(S) David Gray, Robert Kaste , and Paul Moy 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7

Issues in Navy Management of Major Weapon Systems Warranties.

DTIC Science & Technology

1986-12-01

THESISA ISSUES IN NAVY MANAGEMENT OF MAJOR WEAPON SYSTEMS WARRANTIES by Kevin L. White December 1986 Thesis Advisor: David V. Lamm Approved for...David V. Lamm, Thesis Advisor David C. Roberts, Second Reader Willis R. Greer, Jr., Chairman Department of Administrati e Sciences Knal Dean of and... THESIS -------------------------------13 ’p G. DEFINITIONS---------------------------------------13 H. ORGANIZATION OF THE STUDY----------------------- 15

47 CFR 9.5 - E911 Service.

Code of Federal Regulations, 2010 CFR

2010-10-01

... interconnected VoIP services. Further, the following requirements apply only to 911 calls placed by users whose..., includes a selective router). (b) E911 Service. As of November 28, 2005: (1) Interconnected VoIP service... as described in this section; (2) Interconnected VoIP service providers must transmit all 911 calls...

47 CFR 9.5 - E911 Service.

Code of Federal Regulations, 2011 CFR

2011-10-01

... interconnected VoIP services. Further, the following requirements apply only to 911 calls placed by users whose..., includes a selective router). (b) E911 Service. As of November 28, 2005: (1) Interconnected VoIP service... as described in this section; (2) Interconnected VoIP service providers must transmit all 911 calls...

Apollo 9 - Prime Crew - Apollo Command Module (CM)-103 - Post-Test

NASA Image and Video Library

1968-07-19

S68-42164 (19 July 1968) --- The prime crew of the third manned Apollo space mission stands in front of the Apollo Command Module 103 after egress during crew compartment fit and function test activity. Left to right are astronauts Russell L. Schweickart, David R. Scott, and James A. McDivitt.

[Inheritance of reversions to male fertility in male-sterile sorghum hybrids with 9E cytoplasm male sterility induced by environmental conditions].

PubMed

Elkonin, L A; Gerashchenkov, G A; Domanina, I V; Rozhnova, N A

2015-03-01

Heritable phenotypic alterations occurring during plant ontogenesis under the influence of environmental factors are among the most intriguing genetic phenomena. It was found that male-sterile sorghum hybrids in the 9E cytoplasm from the F1 and F2 generations, which were obtained by crossing CMS lines with different fertile lines grown in field conditions, were transferred to greenhouse produce fertile tillers. Lines created by the self-pollination of revertant tillers exhibit complete male fertility upon cultivation under various environments (in the field, Tdry plot,(y) Tirrigated plot(y)). In a number of test-crosses of revertants to CMS lines in the 9E cytoplasm, restoration of male fertility in F1 hybrids was found, indicating that revertants possess functional fertility-restoring genes. A high positive correlation was found between the fertility level of the test-cross hybrids and the hydrothermal coefficient (the ratio of the sum of precipitation to the sum of temperatures) during the booting stage and pollen maturation (r = 0.75...0.91; P<0.01), suggesting that a high level of plant water availability is needed for the expression of fertility-restoring genes of revertants. These data show that the fertility-restoring genes for the 9E cytoplasm are dominant in conditions of high water availability and recessive in drought conditions; reversions to male fertility are due to up-regulation of fertility-restoring genes by a high level of water availability. Comparative MSAP-analysis of DNA of male-sterile and male-fertile test-cross hybrids using HpaII/MspI restrictases and primers to polygalacturonase gene ADPG2, which is required for cell separation during reproductive development, and gene MYB46, the transcription factor regulating secondary wall biosynthesis, revealed differences in the number and the length of amplified fragments. Changes in the methylation of these genes in conditions of drought stress are apparently the reason for male sterility of

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D.

PubMed

Sierksma, A S R; van den Hove, D L A; Pfau, F; Philippens, M; Bruno, O; Fedele, E; Ricciarelli, R; Steinbusch, H W M; Vanmierlo, T; Prickaerts, J

2014-02-01

Phosphodiesterase type 4 inhibitors (PDE4-Is) have received increasing attention as cognition-enhancers and putative treatment strategies for Alzheimer's disease (AD). By preventing cAMP breakdown, PDE4-Is can enhance intracellular signal transduction and increase the phosphorylation of cAMP response element-binding protein (CREB) and transcription of proteins related to synaptic plasticity and associated memory formation. Unfortunately, clinical development of PDE4-Is has been seriously hampered by emetic side effects. The new isoform-specific PDE4D-I, GEBR-7b, has shown to have beneficial effects on memory at non-emetic doses. The aim of the current study was to investigate chronic cognition-enhancing effects of GEBR-7b in a mouse model of AD. To this extent, 5-month-old (5M) APPswe/PS1dE9 mice received daily subcutaneous injections with GEBR-7b (0.001 mg/kg) or vehicle for a period of 3 weeks, and were tested on affective and cognitive behavior at 7M. We demonstrated a cognition-enhancing potential in APPswe/PS1dE9 mice as their spatial memory function at 7M in the object location test was improved by prior GEBR-7b treatment. APPswe/PS1dE9 mice displayed lower levels of CREB phosphorylation, which remained unaltered after chronic GEBR-7b treatment, and higher levels of tau in the hippocampus. Hippocampal brain-derived neurotrophic factor levels and synaptic densities were not different between experimental groups and no effects were observed on hippocampal GSK3β and tau phosphorylation or Aβ levels. In conclusion, GEBR-7b can enhance spatial memory function in the APPswe/PS1dE9 mouse model of AD. Although the underlying mechanisms of its cognition-enhancing potential remain to be elucidated, PDE4D inhibition appears an interesting novel therapeutic option for cognitive deficits in AD. Copyright © 2013 Elsevier Ltd. All rights reserved.

Molecular cloning, expression, IgE binding activities and in silico epitope prediction of Per a 9 allergens of the American cockroach

PubMed Central

Yang, Haiwei; Chen, Hao; Jin, Min; Xie, Hua; He, Shaoheng; Wei, Ji-Fu

2016-01-01

Per a 9 is a major allergen of the American cockroach (CR), which has been recognized as an important cause of imunoglobulin E-mediated type I hypersensitivity worldwide. However, it is not neasy to obtain a substantial quantity of this allergen for use in functional studies. In the present study, the Per a 9 gene was cloned and expressed in Escherichia coli (E. coli) systems. It was found that 13/16 (81.3%) of the sera from patients with allergies caused by the American CR reacted to Per a 9, as assessed by enzyme-linked immunosorbent assay, confirming that Per a 9 is a major allergen of CR. The induction of the expression of CD63 and CCR3 in passively sensitized basophils (from sera of patients with allergies caused by the American CR) by approximately 4.2-fold indicated that recombinant Per a 9 was functionally active. Three immunoinformatics tools, including the DNASTAR Protean system, Bioinformatics Predicted Antigenic Peptides (BPAP) system and the BepiPred 1.0 server were used to predict the potential B cell epitopes, while Net-MHCIIpan-2.0 and NetMHCII-2.2 were used to predict the T cell epitopes of Per a 9. As a result, we predicted 11 peptides (23–28, 39–46, 58–64, 91–118, 131–136, 145–154, 159–165, 176–183, 290–299, 309–320 and 338–344) as potential B cell linear epitopes. In T cell prediction, the Per a 9 allergen was predicted to have 5 potential T cell epitope sequences, 119–127, 194–202, 210–218, 239–250 and 279–290. The findings of our study may prove to be useful in the development of peptide-based vaccines to combat CR-induced allergies. PMID:27840974

IgE Inhibits Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Expression of Interferon-α by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus.

PubMed

Khoryati, Liliane; Augusto, Jean-François; Shipley, Emilie; Contin-Bordes, Cécile; Douchet, Isabelle; Mitrovic, Stéphane; Truchetet, Marie-Elise; Lazaro, Estibaliz; Duffau, Pierre; Couzi, Lionel; Jacquemin, Clément; Barnetche, Thomas; Vacher, Pierre; Schaeverbeke, Thierry; Blanco, Patrick; Richez, Christophe

2016-09-01

Plasmacytoid dendritic cells (PDCs) play a central role in pathogenesis of systemic lupus erythematosus (SLE) through their unique ability to produce large amounts of type I interferon (IFN) upon Toll-like receptor 7 (TLR-7) and TLR-9 triggering. PDCs express specific surface regulatory receptors involved in negative regulation of IFNα secretion. These receptors use the γ-chain of high-affinity Fc receptor (FcR) for IgE, FcɛRI. We undertook this study to test our hypothesis that IgE engagement of FcɛRI on PDCs may impact IFNα production in SLE patients. Serum levels of total IgE were measured in healthy volunteers, SLE patients, and patients with IgE-dependent allergic disorders. FcɛRI expression on PDCs from SLE patients was evaluated by flow cytometry. Purified PDCs were incubated with monoclonal IgE for 24 hours, then stimulated for 18 hours with TLR agonists or immune complexes (ICs). IFNα production by PDCs was detected by quantitative real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay. Expression of TLR-7, TLR-9, and IFN regulatory factor 7 (IRF-7) in PDCs was quantified by quantitative real-time PCR. We observed significantly higher IgE levels in SLE patients with quiescent disease than in those with active disease. In SLE patients, IgE levels correlated inversely with disease activity. IgE levels were not associated with the presence of antinuclear IgE. Purified PDCs treated for 24 hours with monoclonal IgE up-regulated FcɛRI expression in an IgE dose-dependent manner. IgE-treated PDCs significantly decreased IFNα secretion and down-regulated CCR7 expression upon stimulation with TLR-7 and TLR-9 ligands and ICs from lupus patients. IgE treatment down-regulated expression of TLR-9 and IRF-7. Our results support the notion that IgE plays a protective role in SLE pathogenesis through the modulation of inflammatory response by PDCs. © 2016, American College of Rheumatology.

40 CFR 257.9 - Wetlands.

Code of Federal Regulations, 2010 CFR

2010-07-01

... actions (e.g., restoration of existing degraded wetlands or creation of man-made wetlands); and (5... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Wetlands. 257.9 Section 257.9... Location Restrictions § 257.9 Wetlands. (a) Owners or operators of new units and lateral expansions shall...

40 CFR 257.9 - Wetlands.

Code of Federal Regulations, 2011 CFR

2011-07-01

... actions (e.g., restoration of existing degraded wetlands or creation of man-made wetlands); and (5... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Wetlands. 257.9 Section 257.9... Location Restrictions § 257.9 Wetlands. (a) Owners or operators of new units and lateral expansions shall...

Utilization of Forward Error Correction (FEC) Techniques With Extensible Markup Language (XML) Schema-Based Binary Compression (XSBC) Technology

DTIC Science & Technology

2004-12-01

NY 7. Erik Chaum NUWC Newport, RI 8. David Bellino NPRI Newport, RI 9. Dick Nadolink NUWC Newport, RI 10. VADM Roger Bacon (Ret...Science Advisor Pearl Harbor, HI 16. LT Andrew Hurvitz, USN FNMOC Monterey, CA 17. ENS Darin Keeter, USN FNMOC Monterey, CA 18. CAPT David

U.S.-Thailand Relations: Analysis of U.S. Military Support to the Kingdom of Thailand

DTIC Science & Technology

2008-01-01

Chen, 1. 7 David K. Wyatt, Thailand: A Short History ( Chiang Mai , Thailand: Silkworm Books, 2003),278. 8 Wyatt, 277. 9 U.S. Department of State...westhawk.blogspot.com/2008/02/marine-corps-expeditionary-plan-is.html Wyatt, David K. Thailand: A Short History. Chiang Mai , Thailand: Silkworm Books

Obituary: David Fulmer Bender, 1913-2004

NASA Astrophysics Data System (ADS)

Miller, Sylvia L.

2004-12-01

David Fulmer Bender died in San Diego, California, on 13 September 2004, at the age of 91. His heart stopped suddenly while he was dancing. His pioneering work in establishing comprehensive, computer-accessible ephemerides of asteroids and comets found many applications, including the first-ever visit to an asteroid, Gaspra, by an interplanetary spacecraft. Dave was born in Reno, Nevada, on 10 February 1913, to Homer Charles Bender and Susan Bowers Bender. The family moved to Spokane, Washington, while Dave was very young. His father was a civil engineer and a graduate of MIT, who helped design bridges and dams throughout the Northwest, including the Grand Coolie Dam. Dave had a brother, Phillip (now deceased), who was one year younger. Advancing rapidly in the Spokane school system, Dave finished high school when he was 15 years old. At 16 he moved to Pasadena, California, and began his studies at the California Institute of Technology (Caltech). In addition to pursuing his course work, he was active in track and football, a tendency toward physical exercise that stayed with him for the rest of his life. It was probably during these years that Dave heard a lecture by Albert Einstein, as mentioned to colleagues many years later. Dave received a BS degree in physics in 1933, an MS in 1934, and a PhD in 1937, all from Caltech. His dissertation was entitled, "The Index of Refraction of Air in the Photographic Infrared." During his sophomore year he found his way to Pomona College in Claremont, California, where he met his future wife, Elizabeth Boyden at a social gathering. They were married in 1935. Dave's academic career spanned the years from 1937 to 1970, initially at Louisiana State University, Vanderbilt University, and then Fisk. As a life-long pacifist and conscientious objector, Dave served alternate duty during World War II. In 1946 he joined the faculty of the physics department at Whittier College in California, where he became the department chair and

Nuclear Strategy and National Style. Volume 2. Appendices. National Strategic Style: Country Studies

DTIC Science & Technology

1981-07-31

AIHoRO) 9. CONTRACT ON GRANT MUMOE() Edward S. Boylan Rebecca V. Strode DNA oo-8o-c-O121 Robin Ranger David S. Yost PIroiect Leader: ’Cohn inS t...Appendix B--THE FRENCH WAY OF WAR. by David S. Yost ................................................ 31 France’s History as a Great Power...PP.34i7-348. 30 APPENDIX 8 THE FRENCH WAY OF WAR David S. Yost The purpose of this essay is to explore some possible answers to the following questions

Conference on the Neurobiology of Learning and Memory (2nd).

DTIC Science & Technology

1986-05-30

Illinois The Rockefeller University 603 E. Daniel 1230 York Ave. Champaign, IL 61820 New York, NY 10021 Mr. Steven M. Guich Dr. Franz Hock Social Sciences...Psychology Edmonton, Alberta T6H 2B9 John Hopkins University Canada Baltimore, MD 21218 Mr. Steven Hampson Ms. Carol A. Hunt Information and Computer...Irvine, CA 92717 University of California Irvine, CA 92717 Dr. David LaBerge Cognitive Sciences Mr. Richard S. Lewis University of California Department

Apollo 40th Anniversary Press Conference

NASA Image and Video Library

2009-07-19

Apollo astronauts from left, Walt Cunningham (Apollo 17), James Lovell (Apollo 8 Apollo 13), David Scott (Apollo 9 Apollo 15), Buzz Aldrin (Apollo 11), Charles Duke (Apollo 16), Thomas Stafford (Apollo 10) and Eugene Cernan (Apollo 17) are seen during the 40th anniversary of the Apollo 11 mission and the walk on the moon press conference, Monday, July 20, 2009, at NASA Headquarters in Washington. Photo Credit: (NASA/Paul E. Alers)

Diurnal and Semidiurnal Tides in the Middle Atmosphere over Balasore (21.5°N, 86.9°E).

NASA Astrophysics Data System (ADS)

Sasi, M. N.; Krishna Murthy, B. V.

1990-09-01

Using rocket wind data at a tropical station, Balasore (21.5°N, 86.9°E), the diurnal and semidiurnal tidal amplitudes and phases of the zonal and meridional components have been obtained over an altitude range of 20-65 km for equinox, summer and winter seasons. Comparison with the theoretical values revealed some important differences between the two and the implications of these are discussed.

MB109 as bioactive human bone morphogenetic protein-9 refolded and purified from E. coli inclusion bodies

PubMed Central

2014-01-01

Background The development of chemical refolding of transforming growth factor-beta (TGF-β) superfamily ligands has been instrumental to produce the recombinant proteins for biochemical studies and exploring the potential of protein therapeutics. The osteogenic human bone morphogenetic protein-2 (hBMP-2) and its Drosophila DPP homolog were the early successful cases of refolding into functional form. Despite the similarity in their three dimensional structure and amino acid sequences, several other TGF-β superfamily ligands could not be refolded readily by the same methods. Results Here, we report a comprehensive study on the variables of a rapid-dilution refolding method, including the concentrations of protein, salt, detergent and redox agents, pH, refolding duration and the presence of aggregation suppressors and host-cell contaminants, in order to identify the optimal condition to refold human BMP-9 (hBMP-9). To produce a recombinant form of hBMP-9 in E. coli cells, a synthetic codon-optimized gene was designed to encode the mature domain of hBMP-9 (Ser320 – Arg429) directly behind the first methionine, which we herein referred to as MB109. An effective purification scheme was also developed to purify the refolded MB109 to homogeneity with a final yield of 7.8 mg from 100 mg of chromatography-purified inclusion bodies as a starting material. The chemically refolded MB109 binds to ALK1, ActRIIb and BMPRII receptors with relatively high affinity as compared to other Type I and Type II receptors based on surface plasmon resonance analysis. Smad1-dependent luciferase assay in C2C12 cells shows that the MB109 has an EC50 of 0.61 ng/mL (25 pM), which is nearly the same as hBMP-9. Conclusion MB109 is prone to be refolded as non-functional dimer and higher order multimers in most of the conditions tested, but bioactive MB109 dimer can be refolded with high efficiency in a narrow window, which is strongly dependent on the pH, refolding duration, the presence of

75 FR 59327 - Qualification of Drivers; Exemption Applications; Vision

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... exemption for a renewable two-year period. They are: Paul G. Albrecht Elijah A. Allen, Jr. David W. Brown.... Kildow Daniel A. McNabb David G. Meyers Thomas L. Oglesby Michael J. Paul Russell A. Payne Rodney M. Pegg Raymond E. Peterson Zbigniew P. Pietranik John C. Rodriguez Terrance L. Trautman Charles E. Wood Joseph F...

SYTO9 and SYBR GREEN1 with a high-resolution melting analysis for prenatal diagnosis of β⁰-thalassemia/hemoglobin-E.

PubMed

Pornprasert, Sakorn; Sukunthamala, Kanyakan

2010-11-01

The β⁰-thalassemia/Hb-E causes a wide range of severe conditions. A high medical cost is incurred in severe cases. Thus, the prevention of new cases of β⁰-thalassemia/Hb-E is required. The aim of this study is to use the SYTO9 and SYBR GREEN1 high-resolution melting (HRM) analysis for prenatal diagnosis of β⁰-thalassemia/Hb-E. DNA samples were extracted from amniotic fluid or cord blood of 11 pregnancies whose fetuses were at risk for β-thalassemia/Hb-E. PCR products from multiplex amplification refractory mutation system PCR for the detection of β⁰-thalassemia mutations at codons 17(A>T), 41/42(-TCTT), and 71/72(+A) and from amplification refractory mutation system PCR for the detection of Hb-E were characterized by SYTO9 HRM analysis. Moreover, β⁰-thalassemia 3.5- kb deletion was detected using real-time PCR with SYBR GREEN1 HRM analysis. Seven of 11 fetuses (64%) were diagnosed as β⁰-thalassemia/Hb-E (4 fetuses with mutation at codon 17, 2 with mutation at codon 41/42, and 1 with 3.5- kb deletion). Results from HRM analysis were completely consistent with those from fetal blood samplings analyzed at the time of delivery or pregnancy termination using HPLC. Therefore, the HRM analysis is easy to use. It is simple, flexible, non-destructive and has superb sensitivity and specificity. This approach might facilitate the laboratory diagnosis and genetic counseling for regions with a high prevalence of β⁰-thalassemia/Hb-E. © 2010 John Wiley & Sons A/S.

2012 ARPA-E Energy Innovation Summit: Profiling Sheetak: Low Cost - Solid State Cooling

ScienceCinema

Pokharna, Himanshu; Ghoshal, Uttam

2018-05-30

The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. A few videos were selected for showing during the Summit to attendees. These "performer videos" highlight innovative research that is ongoing and related to the main topics of the Summit's sessions. Featured in this video are David Marcus, Founder of General Compression, and Eric Ingersoll, CEO of General Compression. Himanshu Pokharna, Vice President of Sheetak Uttam Ghoshal, President and CEO of Sheetak.

CrossTalk: The Journal of Defense Software Engineering. Volume 19, Number 3

DTIC Science & Technology

2006-03-01

Humphreys & Associates, Inc., 2002. 3. Humphrey , Watts S . PSP : A Self- Improvement Process for...sanderfer.html>. 5. Humphrey , Watts S . A Discipline for Software Engineering. Addison- Wesley, 1995. 6. Tuma, David, and David R. Webb. “Personal Earned Value: Why...o u r c e li n e s o f c o d e ) Figure 3: Differences for Highest Degree Attained PSP /TSP 12 CROSSTALK The Journal of Defense Software

27 CFR 9.56 - San Lucas.

Code of Federal Regulations, 2014 CFR

2014-04-01

... mile to the 630-foot promontory in section 32, T. 20 S., R. 9 E.; (1) Then east southeasterly in a straight line approximately 0.6 mile to the 499-foot promontory in the southwest corner of section 33, T. 20 S., R. 9 E.; (2) Then east southeasterly in a straight line approximately 1.3 miles to the 847...

27 CFR 9.56 - San Lucas.

Code of Federal Regulations, 2011 CFR

2011-04-01

... mile to the 630-foot promontory in section 32, T. 20 S., R. 9 E.; (1) Then east southeasterly in a straight line approximately 0.6 mile to the 499-foot promontory in the southwest corner of section 33, T. 20 S., R. 9 E.; (2) Then east southeasterly in a straight line approximately 1.3 miles to the 847...

27 CFR 9.56 - San Lucas.

Code of Federal Regulations, 2010 CFR

2010-04-01

... mile to the 630-foot promontory in section 32, T. 20 S., R. 9 E.; (1) Then east southeasterly in a straight line approximately 0.6 mile to the 499-foot promontory in the southwest corner of section 33, T. 20 S., R. 9 E.; (2) Then east southeasterly in a straight line approximately 1.3 miles to the 847...

27 CFR 9.56 - San Lucas.

Code of Federal Regulations, 2012 CFR

2012-04-01

... mile to the 630-foot promontory in section 32, T. 20 S., R. 9 E.; (1) Then east southeasterly in a straight line approximately 0.6 mile to the 499-foot promontory in the southwest corner of section 33, T. 20 S., R. 9 E.; (2) Then east southeasterly in a straight line approximately 1.3 miles to the 847...

27 CFR 9.56 - San Lucas.

Code of Federal Regulations, 2013 CFR

2013-04-01

... mile to the 630-foot promontory in section 32, T. 20 S., R. 9 E.; (1) Then east southeasterly in a straight line approximately 0.6 mile to the 499-foot promontory in the southwest corner of section 33, T. 20 S., R. 9 E.; (2) Then east southeasterly in a straight line approximately 1.3 miles to the 847...

CREW TRAINING (TOYS) - STS-51E - JSC

NASA Image and Video Library

1985-01-26

S85-26475 (1 February 1985) --- Astronaut David Griggs, 51-D mission specialist, monitors the behavior of a pink plastic flipping toy, nicknamed "Rat Stuff." The small toy is part of the "Toys in Space" project for NASA's 51-D mission.

CRISPR/Cas9-Mediated Mutagenesis of Human Pluripotent Stem Cells in Defined Xeno-Free E8 Medium.

PubMed

Soh, Chew-Li; Huangfu, Danwei

2017-01-01

The recent advent of engineered nucleases including the CRISPR/Cas9 system has greatly facilitated genome manipulation in human pluripotent stem cells (hPSCs). In addition to facilitating hPSC-based disease studies, the application of genome engineering in hPSCs has also opened up new avenues for cell replacement therapy. To improve consistency and reproducibility of hPSC-based studies, and to meet the safety and regulatory requirements for clinical translation, it is necessary to use a defined, xeno-free cell culture system. This chapter describes protocols for CRISPR/Cas9 genome editing in an inducible Cas9 hPSC-based system, using cells cultured in chemically defined, xeno-free E8 Medium on a recombinant human vitronectin substrate. We detail procedures for the design and transfection of CRISPR guide RNAs, colony selection, and the expansion and validation of clonal mutant lines, all within this fully defined culture condition. These methods may be applied to a wide range of genome-engineering applications in hPSCs, including those that utilize different types of site-specific nucleases such as zinc finger nucleases (ZFNs) and TALENs, and form a closer step towards clinical utility of these cells.

Local knowledge, state power, and the science of industrial labor relations: William Leiserson, David Saposs, and American labor economics in the interwar years.

PubMed

Wang, Jessica

2010-01-01

Recent scholarship has frequently emphasized modern states' use of social science to impose universalized conceptions of rationality and order upon diverse, highly localized settings. The New Deal era experiences of William M. Leiserson and David J. Saposs, however, provide an analytical alternative. As students of the pioneering labor economist John R. Commons, Leiserson and Saposs sought to create mechanisms for state oversight of industrial labor relations that recognized local practices and arrangements. Although their approach failed to take hold within the National Labor Relations Board, localized institutional and political contingencies, and not a hegemonic modernism, account best for their frustrated aspirations in the late 1930s. © 2010 Wiley Periodicals, Inc.

David Bowie and the Art of Slow Innovation: A Fast-Second Winner Strategy for Biotechnology and Precision Medicine Global Development.

PubMed

Özdemir, Vural; Patrinos, George P

2017-11-01

Original ideas and innovation cannot always be ordered like a courier service and delivered fresh to our desk at 9 am. Yet, most creativity-based organizations, careers, and professions, science and biotechnology innovation included, emphasize the speed as the prevailing ideology. But a narrow focus on speed has several and overlooked shortcomings. For example, it does not offer the opportunity to draw from, and stitch together disparate concepts and practices for truly disruptive innovation. Preventing false starts, learning from others' or our own mistakes, and customizing innovations for local community needs are difficult in a speed-hungry innovation ecosystem. We introduce a new strategy, the Fast-Second Winner, specifically in relation to global development of biotechnologies and precision medicine. This à la carte global development strategy envisions a midstream entry into the innovation ecosystem. Moreover, we draw from the works of the late David Bowie who defied rigid classifications as an artist and prolific innovator, and introduce the concept and practice of slow innovation that bodes well with the Fast-Second Winner strategy. A type of slow innovation, the Fast-Second Winner is actually fast and sustainable in the long term, and efficient by reducing false starts in new precision medicine application contexts and geographies, learning from other innovators' failures, and shaping innovations for the local community needs. The establishment of Centers for Fast-Second Innovation (CFSIs), and their funding, for example, by crowdfunding and other innovative mechanisms, could be timely for omics and precision medicine global development. If precision medicine is about tailoring drug treatments and various health interventions to individuals, we suggest to start from tailoring new ideas, and focus not only on how much we innovate but also what and how we innovate. In principle, the Fast-Second Winner can be applied to omics and other biotechnology

Observations of neutral winds in the auroral E region during the magnetospheric storm of August 3-9, 1972

NASA Technical Reports Server (NTRS)

Brekke, A.; Doupnik, J. R.; Banks, P. M.

1974-01-01

Auroral zone E-region neutral winds have been derived from simultaneous measurements of ion drift velocities in different altitudes by the incoherent radar facility at Chatanika, Alaska, on a quiet day before and during the great magnetospheric storm of Aug. 3-9, 1972. The neutral wind expected for a day-night pressure asymmetry appears to be strongly opposed by ion drag and local pressure gradients in the auroral oval.

Optical and Photophysical Investigation of (2E)-1-(2,5-Dimethylfuran-3-Yl)-3-(9-Ethyl-9H-Carbazol-3-Yl)Prop-2-en-1-One (DEPO) by Spectrofluorometer in Organized Medium.

PubMed

Asiri, Abdullah M; Al-Dies, Al-Anood M; Khan, Salman A

2017-07-01

(2E)-1-(2,5-dimethylfuran-3-yl)-3-(9-ethyl-9H-carbazol-3-yl)prop-2-en-1-one (DEPO) was prepared by the reaction of 9-ethyl-9H-carbazole-3-carbaldehyde with 1-(2,5-dimethylfuran-3-yl)ethanone under microwave irradiation. The structure of DEPO was established experimentally by EI-MS, FT-IR, 1 H and 13 C NMR spectral studies. Electronic absorption and emission spectra of DEPO were studied in different solvents on the basis of polarities, and the obtain data were used to determine the solvatochromic properties such as extinction coefficient, oscillator strength, transition dipole moment, stokes shift, fluorescence quantum yield and photochemical quantum yield. Photochemical quantum yield (Φ c ) of DEPO dye was determined in different solvent. The dye comparatively photostable in DMSO but undergoes photodecomposition in chloro methane solvents. The DEPO dye may be use as probe or quencher to determine critical micelle concentration (CMC) of cetyltri methyl ammonium bromide (CTAB) and sodium dodecyl sulfate (SDS).

Prevalence of immunoglobulin E-mediated food allergy in 6-9-year-old urban schoolchildren in the eastern Black Sea region of Turkey.

PubMed

Orhan, F; Karakas, T; Cakir, M; Aksoy, A; Baki, A; Gedik, Y

2009-07-01

The prevalence of adverse reactions to food in childhood in Turkey is not known. We aimed to investigate the prevalence and characteristics of IgE-mediated food allergies (FAs) in 6-9-year-old urban schoolchildren. This cross-sectional study recruited 3500 of the randomly selected 6-9-year-old urban schoolchildren from the eastern Black Sea region of Turkey during 2006. Following a self-administered questionnaire completed by the parents and the child, consenting children were invited for skin prick tests (SPTs) and oral food challenges. Children with suspected IgE-mediated FA were skin prick tested with a predefined panel of food allergens (milk, hen's egg, soy, wheat, peanut, fish, and hazelnut), aeroallergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat, dog, Alternaria, grass pollen mix, weed pollen mix, and tree pollen mix), and food allergens reported in the questionnaire. All children with a positive SPT to any food were invited for a double-blind, placebo-controlled food challenge (DBPCFC). The prevalence of IgE-mediated FA was established using DBPCFCs. The response rate to the questionnaire was 78.2% (2739/3500). The estimated prevalence of parental-reported IgE-mediated FA was 5.7% (156/2739) [95% confidence interval (CI), 4.83-6.57%]. The rate of sensitization to the food allergens was 33.1% (48/145) in the parental-reported group. The confirmed prevalence of IgE-mediated FA by means of DBPCFC in 6-9-year-old urban schoolchildren living in the eastern Black Sea region of Turkey was 0.80% (22/2739) (95% CI, 0.47-1.13%). The most common allergenic foods were beef (31.8%), cow's milk (18.1%), cocoa (18.1%), hen's egg (13.6%), and kiwi (13.6%). The rate of reported IgE-mediated FA was significantly higher than clinically confirmed FA by means of DBPCFC (odds ratio, 7.46; 95% CI, 4.67-12.01; P<0.0001). The order of allergenic foods was different and somewhat unique to the eastern Black Sea region of Turkey when compared with western

Interleukin-7 (IL-7) enhances class switching to IgE and IgG4 in the presence of T cells via IL-9 and sCD23.

PubMed

Jeannin, P; Delneste, Y; Lecoanet-Henchoz, S; Gretener, D; Bonnefoy, J Y

1998-02-15

Interleukin-7 (IL-7) is a B-cell growth factor produced by both bone marrow stroma cells and follicular dendritic cells (FDCs) located in primary lymphoid follicles and germinal centers. In this study, we have evaluated the role of IL-7 on human Ig class switching. IL-7 was added to peripheral blood mononuclear cells (PBMCs) or tonsillar B cells in the absence or presence of IL-4 and/or anti-CD40 monoclonal antibody (MoAb). Alone, IL-7 did not affect Ig production by PBMCs or by anti-CD40 MoAb-stimulated B cells. Rather, IL-7 potentiated IL-4-induced IgE and IgG4 production by PBMCs. In parallel, IgG3 production was also enhanced but to a lesser extent, whereas the production of the other isotypes was unaltered. The activity of IL-2, IL-9, or IL-15, which share usage of the common gamma chain for signaling, was also assessed. IL-9, like IL-7, potentiated mainly IgE and IgG4 production by IL-4-stimulated PBMCs. IL-15, in contrast, was ineffective, whereas IL-2 enhanced the production of all isotypes. More precisely, IL-7 potentiation of IgE and IgG4 production required the presence of T cells and was accompanied by an increase of the expression of two soluble molecules favoring preferentially IgE and IgG4 synthesis: CD23 (sCD23) and IL-9. Moreover, neutralizing anti-CD23 and anti-IL-9 antibodies partly inhibited the increase of IgE synthesis induced by IL-7. Thus, IL-7 produced locally in the germinal centers by FDCs may interact with T cells and potentiate human IgE and IgG4 switching by favoring IL-9 and sCD23 production.

2012 ARPA-E Energy Innovation Summit: Profiling General Compression: A River of Wind

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marcus, David; Ingersoll, Eric

The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. A few videos were selected for showing during the Summit to attendees. These 'performer videos' highlight innovative research that is ongoing and related to the main topics of the Summit's sessions. Featured in this video are David Marcus, Founder of General Compression, and Eric Ingersoll, CEO of General Compression. General Compression,more » with the help of ARPA-E funding, has created an advanced air compression process which can store and release more than a weeks worth of the energy generated by wind turbines.« less

Maternal separation exacerbates Alzheimer's disease-like behavioral and pathological changes in adult APPswe/PS1dE9 mice.

PubMed

Hui, Jianjun; Feng, Gaifeng; Zheng, Caifeng; Jin, Hui; Jia, Ning

2017-02-01

Alzheimer's disease (AD), the most common neurodegenerative disorder that gradually destroys memory and cognitive abilities in the elderly, makes a huge emotional and economic burden on the patients and their families. The presence of senile plaques and the loss of cholinergic neurons in the brain are two neuropathological hallmarks of AD. Maternal separation (MS) is an animal paradigm designed to make early life stress. Studies on wild type rodents showed that MS could induce AD-like cognitive deficit and pathological changes. However, the effects of MS on AD susceptible population or AD animal models are still unclear. In the present study, male APPswe/PS1dE9 transgenic mice were separated from dam and pups 3h per day from postnatal day 2 to day 21. After weaning, all animals were housed under normal conditions (4 mice per cage). At 9-month age, MWM tests were performed to evaluate the learning and memory abilities. Then the pathological changes in the brain were measured by histology staining. The results showed MS mice had more severe deficit of learning and memory. Compared to the control, there were more senile plaques in cortex and hippocampus, fewer cholinergic neurons in nucleus basalis of Meynert in MS mice. These results indicate that MS exacerbates Alzheimer's disease-like behavioral and pathological changes in APPswe/PS1dE9 mice. Copyright © 2016 Elsevier B.V. All rights reserved.

Impact of eLearning course on nurses' professional competence in seclusion and restraint practices: 9-month follow-up results of a randomized controlled study (ISRCTN32869544).

PubMed

Kontio, R; Hätönen, H; Joffe, G; Pitkänen, A; Lahti, M; Välimäki, M

2013-04-01

eLearning may facilitate continuing vocational education, but data on the long-term effects of an eLearning course are lacking. The aim of this study was to explore the long-term impact of an eLearning course entitled ePsychNurse.Net on psychiatric nurses' professional competence in practicing seclusion and restraint and on their job satisfaction and general self-efficacy at 9-month follow-up. In a randomized controlled study, 12 wards were randomly assigned to the ePsychNurse.Net (intervention) or training as usual (control). Baseline and 9-month follow-up data on nurses' knowledge of coercion-related legislation, physical restraint and seclusion, their attitudes towards physical restraint and seclusion, job satisfaction and general self-efficacy were analysed for 137 completers (those who participated in the 9-month follow-up assessment). No between-group differences were found on any variable, with the exception of a change in attitude to seclusion in favour of the control group. The findings of the long-term effects did not differ from the immediate outcomes (3-month follow-up) and the improved level of knowledge acquired and further consolidation of that knowledge did not take place in the 6-month period after the 3-month ePsychNurse.Net course. The ePsychNurse.Net should be further developed and its future modifications will require additional studies, probably with some new outcome measures. © 2012 Blackwell Publishing.

Sleep: The E-ZZZ Intervention

ERIC Educational Resources Information Center

Bergin, Christi A.; Bergin, David A.

2009-01-01

Research has shown that students who do not get enough sleep are more likely to misbehave in school and have lower academic achievement than their peers with healthy sleeping habits. In this article, Christi A. Bergin and David A. Bergin share research into students' sleep habits and conclude that helping students get adequate sleep has potential…

Underkill. Scalable Capabilities for Military Operations Amid Populations

DTIC Science & Technology

2009-01-01

Purchase this document Browse Books & Publications Make a charitable contribution Support RAND Report Documentation Page Form ApprovedOMB No. 0704-0188...Secretary of Defense Approved for public release; distribution unlimited DAVID C. GOMPERT | STUART E . JOHNSON MARTIN C. LIBICKI | DAVID R. FRELINGER... E . Hunter, War by Other Means—Building Complete and Balanced Capabilities for Counterinsurgency: iv Underkill Prompted by this finding, and with

Eclipses and dust formation by WC9 type Wolf-Rayet stars

NASA Astrophysics Data System (ADS)

Williams, P. M.

2014-12-01

Visual photometry of 16 WC8-9 dust-making Wolf-Rayet (WR) stars during 2001-2009 was extracted from the All-Sky Automated Survey All Star Catalogue (ASAS-3) to search for eclipses attributable to extinction by dust formed in clumps in our line of sight. Data for a comparable number of dust-free WC6-9 stars were also examined to help characterize the data set. Frequent eclipses were observed from WR 104, and several from WR 106, extending the 1994-2001 studies by Kato et al., but not supporting their phasing the variations in WR 104 with its `pinwheel' rotation period. Only four other stars showed eclipses, WR 50 (one of the dust-free stars), WR 69, WR 95 and WR 117, and there may have been an eclipse by WR 121, which had shown two eclipses in the past. No dust eclipses were shown by the `historic' eclipsers WR 103 and WR 113. The atmospheric eclipses of the latter were observed but the suggestion by David-Uraz et al. that dust may be partly responsible for these is not supported. Despite its frequent eclipses, there is no evidence in the infrared images of WR 104 for dust made in its eclipses, demonstrating that any dust formed in this process is not a significant contributor to its circumstellar dust cloud and suggesting that the same applies to the other stars showing fewer eclipses.