Interior of the mine observation tower building, showing the steel ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Interior of the mine observation tower building, showing the steel compass ring in the tower. View facing east - U.S. Naval Base, Pearl Harbor, Waipio Peninsula, Waipo Peninsula, Pearl City, Honolulu County, HI

Oblique of mine observation tower building showing entry door and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Oblique of mine observation tower building showing entry door and transformer building behind on right. View facing north-northwest - U.S. Naval Base, Pearl Harbor, Waipio Peninsula, Waipo Peninsula, Pearl City, Honolulu County, HI

Toward Explaining Earlier Retirement after 1970.

ERIC Educational Resources Information Center

Ippolito, Richard A.

1990-01-01

Rule changes in the social security system and pension plans suggest that labor force participation rates for men aged 55 to 64 fell by 20 percent from 1970 through 1986 because of the increase in social security benefits and a change in private pension rules encouraging earlier retirement. (Author/JOW)

Map showing location of observation wells in Massachusetts and Rhode Island

USGS Publications Warehouse

Rader, J.C.

1995-01-01

This map shows the locations of the 136 observation wells from the observation-well network maintained by the U.S. Geological Survey in Massachusetts and Rhode Island. The wells are identified by town name and well number. The map shows the location of the 10 observation wells that have digital recorders and the 126 observation wells that are measured by local observers. The aquifer material (sand, till, or bedrock) in which a well is located is noted. County and town boundaries are shown on the map. These features are presented at a scale of 1:400,000 (map size is about 38 by 30 inches). The map includes textual information describing the uses of observation-well data. The information is organized by construction, water supply, water quality, and statistical analysis. The map also presents observation well information, which was obtained from the annual data report of the Massachusetts--Rhode Island District. This infor- mation is presented in tabular form and includes town name, well number, aquifer material in which the well is located, and well depth below the land surface. The map was produced from a digital data base using a Geographic Information System. State boundaries were generated from digital line graphs maintained by the U.S. Geological Survey. Town and county boundaries were digitized from stable-base materials maintained by State agencies. The map was prepared in cooperation with State agencies of Massachusetts and Rhode Island.

INTERIOR VIEW SHOWING FURNACE KEEPER OBSERVING FURNACE THROUGH BLUE GLASS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

INTERIOR VIEW SHOWING FURNACE KEEPER OBSERVING FURNACE THROUGH BLUE GLASS EVERY TWENTY MINUTES TO DETERMINE SIZE AND TEXTURE OF BATCH AND OTHER VARIABLES. FAN IN FRONT COOLS WORKERS AS THEY CONDUCT REPAIRS. FURNACE TEMPERATURE AT 1572 DEGREES FAHRENHEIT. - Chambers-McKee Window Glass Company, Furnace No. 2, Clay Avenue Extension, Jeannette, Westmoreland County, PA

Earlier tachycardia onset in right than left mesial temporal lobe seizures.

PubMed

Kato, Kazuhiro; Jin, Kazutaka; Itabashi, Hisashi; Iwasaki, Masaki; Kakisaka, Yosuke; Aoki, Masashi; Nakasato, Nobukazu

2014-10-07

To clarify whether the presence and timing of peri-ictal heart rate (HR) change is a seizure lateralizing sign in patients with mesial temporal lobe epilepsy (mTLE). Long-term video EEGs were retrospectively reviewed in 21 patients, 7 men and 14 women aged 13 to 67 years, diagnosed as mTLE with MRI lesions in the mesial temporal structures (hippocampal sclerosis in 20 cases, amygdala hypertrophy in 1 case). Seventy-seven partial seizures without secondary generalization were extracted. Peri-ictal HR change was compared between 29 right seizures (9 patients) and 48 left seizures (12 patients). HR abruptly increased in all 29 right seizures and 42 of 48 left seizures. Onset time of HR increase in relation to ictal EEG onset was significantly earlier in right seizures than in left seizures (mean ± SD, -11.5 ± 14.8 vs 9.2 ± 21.7 seconds; p < 0.0001). Time of maximum HR was also significantly earlier in right seizures than in left seizures (36.0 ± 18.1 vs 58.0 ± 28.7 seconds; p < 0.0001). Maximum HR changes from baseline showed no significant difference between right and left seizures (47.5 ± 19.1 vs 40.8 ± 20.0/min). Significantly earlier tachycardia in right than left mTLE seizures supports previous hypotheses that the right cerebral hemisphere is dominant in the sympathetic network. No HR change, or delayed tachycardia possibly due to seizure propagation to the right hemisphere, may be a useful lateralizing sign of left mTLE seizures. © 2014 American Academy of Neurology.

Earlier warning: a multi-indicator approach to monitoring trends in the illicit use of medicines.

PubMed

Mounteney, Jane; Haugland, Siren

2009-03-01

The availability of medicines on the illicit drug market is currently high on the international policy agenda, linked to adverse health consequences including addiction, drug related overdoses and injection related problems. Continuous surveillance of illicit use of medicines allows for earlier identification and reporting of emerging trends and increased possibilities for earlier intervention to prevent spread of use and drug related harm. This paper aims to identify data sources capable of monitoring the illicit use of medicines; present trend findings for Rohypnol and Subutex using a multi-indicator monitoring approach; and consider the relevance of such models for policy makers. Data collection and analysis were undertaken in Bergen, Norway, using the Bergen Earlier Warning System (BEWS), a multi-indicator drug monitoring system. Data were gathered at six monthly intervals from April 2002 to September 2006. Drug indicator data from seizures, treatment, pharmacy sales, helplines, key informants and media monitoring were triangulated and an aggregated differential was used to plot trends. Results for the 4-year period showed a decline in the illicit use of Rohypnol and an increase in the illicit use of Subutex. Multi-indicator surveillance models can play a strategic role in the earlier identification and reporting of emerging trends in illicit use of medicines.

Compulsive Buying: Earlier Illicit Drug Use, Impulse Buying, Depression, and Adult ADHD Symptoms

PubMed Central

Brook, Judith S.; Zhang, Chenshu; Brook, David W.; Leukefeld, Carl G.

2015-01-01

This longitudinal study examined the association between psychosocial antecedents, including illicit drug use, and adult compulsive buying (CB) across a 29-year time period from mean age 14 to mean age 43. Participants originally came from a community-based random sample of residents in two upstate New York counties. Multivariate linear regression analysis was used to study the relationship between the participant’s earlier psychosocial antecedents and adult CB in the fifth decade of life. The results of the multivariate linear regression analyses showed that gender (female), earlier adult impulse buying (IB), depressive mood, illicit drug use, and concurrent ADHD symptoms were all significantly associated with adult CB at mean age 43. It is important that clinicians treating CB in adults should consider the role of drug use, symptoms of ADHD, IB, depression, and family factors in CB. PMID:26165963

Compulsive buying: Earlier illicit drug use, impulse buying, depression, and adult ADHD symptoms.

PubMed

Brook, Judith S; Zhang, Chenshu; Brook, David W; Leukefeld, Carl G

2015-08-30

This longitudinal study examined the association between psychosocial antecedents, including illicit drug use, and adult compulsive buying (CB) across a 29-year time period from mean age 14 to mean age 43. Participants originally came from a community-based random sample of residents in two upstate New York counties. Multivariate linear regression analysis was used to study the relationship between the participant's earlier psychosocial antecedents and adult CB in the fifth decade of life. The results of the multivariate linear regression analyses showed that gender (female), earlier adult impulse buying (IB), depressive mood, illicit drug use, and concurrent ADHD symptoms were all significantly associated with adult CB at mean age 43. It is important that clinicians treating CB in adults should consider the role of drug use, symptoms of ADHD, IB, depression, and family factors in CB. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Earlier Mother's Age at Menarche Predicts Rapid Infancy Growth and Childhood Obesity

PubMed Central

Ong, Ken K; Northstone, Kate; Wells, Jonathan CK; Rubin, Carol; Ness, Andy R; Golding, Jean; Dunger, David B

2007-01-01

Background Early menarche tends to be preceded by rapid infancy weight gain and is associated with increased childhood and adult obesity risk. As age at menarche is a heritable trait, we hypothesised that age at menarche in the mother may in turn predict her children's early growth and obesity risk. Methods and Findings We tested associations between mother's age at menarche, mother's adult body size and obesity risk, and her children's growth and obesity risk in 6,009 children from the UK population-based Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort who had growth and fat mass at age 9 y measured by dual-energy X-ray absorptiometry. A subgroup of 914 children also had detailed infancy and childhood growth data. In the mothers, earlier menarche was associated with shorter adult height (by 0.64 cm/y), increased weight (0.92 kg/y), and body mass index (BMI, 0.51 kg/m2/y; all p < 0.001). In contrast, in her children, earlier mother's menarche predicted taller height at 9 y (by 0.41 cm/y) and greater weight (0.80 kg/y), BMI (0.29 kg/m2/y), and fat mass index (0.22 kg/m2/year; all p < 0.001). Children in the earliest mother's menarche quintile (≤11 y) were more obese than the oldest quintile (≥15 y) (OR, 2.15, 95% CI 1.46 to 3.17; p < 0.001, adjusted for mother's education and BMI). In the subgroup, children in the earliest quintile showed faster gains in weight (p < 0.001) and height (p < 0.001) only from birth to 2 y, but not from 2 to 9 y (p = 0.3–0.8). Conclusions Earlier age at menarche may be a transgenerational marker of a faster growth tempo, characterised by rapid weight gain and growth, particularly during infancy, and leading to taller childhood stature, but likely earlier maturation and therefore shorter adult stature. This growth pattern confers increased childhood and adult obesity risks. PMID:17455989

Insight Into Illness and Cognition in Schizophrenia in Earlier and Later Life.

PubMed

Gerretsen, Philip; Voineskos, Aristotle N; Graff-Guerrero, Ariel; Menon, Mahesh; Pollock, Bruce G; Mamo, David C; Mulsant, Benoit H; Rajji, Tarek K

2017-04-01

Impaired insight into illness in schizophrenia is associated with illness severity and deficits in premorbid intellectual function, executive function, and memory. A previous study of patients aged 60 years and older found that illness severity and premorbid intellectual function accounted for variance in insight impairment. As such, we aimed to test whether similar relationships would be observed in earlier life. A retrospective analysis was performed on 1 large sample of participants (n = 171) with a DSM-IV-TR diagnosis of schizophrenia aged 19 to 79 years acquired from 2 studies: (1) a psychosocial intervention trial for older persons with schizophrenia (June 2008 to May 2014) and (2) a diffusion tensor imaging and genetics study of psychosis across the life span (February 2007 to December 2013). We assessed insight into illness using the Positive and Negative Syndrome Scale (PANSS) item G12 and explored its relationship to illness severity (PANSS total modified), premorbid intellectual function (Wechsler Test of Adult Reading [WTAR]), and cognition. Insight impairment was more severe in later life (≥ 60 years) than in earlier years (t = -3.75, P < .001). Across the whole sample, the variance of impaired insight was explained by PANSS total modified (Exp[B] = 1.070, P < .001) and WTAR scores (Exp[B] = 0.970, P = .028). Although age and cognition were correlated with impaired insight, they did not independently contribute to its variance. However, the relationships between impaired insight and illness severity and between impaired insight and cognition, particularly working memory, were stronger in later life than in earlier life. These results suggest an opportunity for intervention may exist with cognitive-enhancing neurostimulation or medications to improve insight into illness in schizophrenia across the life span. Original study registered on ClinicalTrials.gov (identifier: NCT00832845). © Copyright 2017 Physicians Postgraduate Press, Inc.

Research promises earlier warning for grapevine canker diseases

USDA-ARS?s Scientific Manuscript database

When it comes to detecting and treating vineyards for grapevine canker diseases (also called trunk diseases), like Botryosphaeria dieback (Bot canker), Esca, Eutypa dieback and Phomopsis dieback, the earlier the better, says plant pathologist Kendra Baumgartner, with the USDA’s Agricultural Research...

An earlier de motu cordis.

PubMed Central

Daly, Walter J.

2004-01-01

Thirteenth century medical science, like medieval scholarship in general, was directed at reconciliation of Greek philosophy/science with prevailing medieval theology and philosophy. Peter of Spain [later Pope John XXI] was the leading medical scholar of his time. Peter wrote a long book on the soul. Imbedded in it was a chapter on the motion of the heart. Peter's De Motu was based on his own medical experience and Galen's De Usu Partium and De Usu Respirationis and De Usu Pulsuum. This earlier De Motu defines a point on the continuum of intellectual development leading to us and into the future. Thirteenth century scholarship relied on past authority to a degree that continues to puzzle and beg explanation. Images Fig. 1 PMID:17060956

Travelling for earlier surgical treatment: the patient's view.

PubMed Central

Stewart, M; Donaldson, L J

1991-01-01

As part of the northern region's programme within the national waiting list initiative, schemes have been funded to test the feasibility and acceptability of offering patients the opportunity to travel further afield in order to receive earlier treatment. A total of 484 patients experiencing a long wait for routine surgical operations in the northern region were offered the opportunity to receive earlier treatment outside their local health district; 74% of the patients accepted the offer. The initiative was well received by the participating patients and the majority stated that if the need arose on a future occasion they would prefer to travel for treatment rather than have to wait for lengthy periods for treatment at their local hospital. These findings, interpreted in the light of the National Health Service reforms introduced in April 1991, suggest that for some types of care, patients would welcome greater flexibility in the placing of contracts, not merely reinforcement of historical patterns of referral. PMID:1823553

Earlier Snowmelt Changes the Ratio Between Early and Late Season Forest Productivity

NASA Astrophysics Data System (ADS)

Knowles, J. F.; Molotch, N. P.; Trujillo, E.; Litvak, M. E.

2017-12-01

Future projections of declining snowpack and increasing potential evaporation associated with climate warming are predicted to advance the timing of snowmelt in mountain ecosystems globally. This scenario has direct implications for snowmelt-driven forest productivity, but the net effect of temporally shifting moisture dynamics is unknown with respect to the annual carbon balance. Accordingly, this study uses both satellite- and tower-based observations to document the forest productivity response to snowpack and potential evaporation variability between 1989 and 2012 throughout the southern Rocky Mountain ecoregion, USA. These results show that a combination of low snow accumulation and record high potential evaporation in 2012 resulted in the 34-year minimum ecosystem productivity that could be indicative of future conditions. Moreover, early and late season productivity were significantly and inversely related, suggesting that future shifts toward earlier or reduced snowmelt could increase late-season moisture stress to vegetation and thus restrict productivity despite a longer growing season. This relationship was further subject to modification by summer precipitation, and the controls on the early/late season productivity ratio are explored within the context of ecosystem carbon storage in the future. Any perturbation to the carbon cycle at this scale represents a potential feedback to climate change since snow-covered forests represent an important global carbon sink.

Prescription stimulant use is associated with earlier onset of psychosis.

PubMed

Moran, Lauren V; Masters, Grace A; Pingali, Samira; Cohen, Bruce M; Liebson, Elizabeth; Rajarethinam, R P; Ongur, Dost

2015-12-01

A childhood history of attention deficit hyperactivity disorder (ADHD) is common in psychotic disorders, yet prescription stimulants may interact adversely with the physiology of these disorders. Specifically, exposure to stimulants leads to long-term increases in dopamine release. We therefore hypothesized that individuals with psychotic disorders previously exposed to prescription stimulants will have an earlier onset of psychosis. Age of onset of psychosis (AOP) was compared in individuals with and without prior exposure to prescription stimulants while controlling for potential confounding factors. In a sample of 205 patients recruited from an inpatient psychiatric unit, 40% (n = 82) reported use of stimulants prior to the onset of psychosis. Most participants were prescribed stimulants during childhood or adolescence for a diagnosis of ADHD. AOP was significantly earlier in those exposed to stimulants (20.5 vs. 24.6 years stimulants vs. no stimulants, p < 0.001). After controlling for gender, IQ, educational attainment, lifetime history of a cannabis use disorder or other drugs of abuse, and family history of a first-degree relative with psychosis, the association between stimulant exposure and earlier AOP remained significant. There was a significant gender × stimulant interaction with a greater reduction in AOP for females, whereas the smaller effect of stimulant use on AOP in males did not reach statistical significance. In conclusion, individuals with psychotic disorders exposed to prescription stimulants had an earlier onset of psychosis, and this relationship did not appear to be mediated by IQ or cannabis. Copyright © 2015 Elsevier Ltd. All rights reserved.

The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas

PubMed Central

Kessler, Ronald C.; Aguilar-Gaxiola, Sergio; Alonso, Jordi; Bromet, Evelyn J.; Gureje, Oye; Karam, Elie G.; Koenen, Karestan C.; Lee, Sing; Liu, Howard; Pennell, Beth-Ellen; Petukhova, Maria V.; Sampson, Nancy A.; Shahly, Victoria L.; Stein, Dan J.; Atwoli, Lukoye; Borges, Guilherme; Bunting, Brendan; de Girolamo, Giovanni; Gluzman, Semyon; Haro, Josep Maria; Hinkov, Hristo; Kawakami, Norito; Kovess-Masfety, Viviane; Navarro-Mateu, Fernando; Posada-Villa, Jose; Scott, Kate M.; Shalev, Arieh Y.; Have, Margreet ten; Torres, Yolanda; Viana, Maria Carmen; Zaslavsky, Alan M.

2017-01-01

Although earlier trauma exposure is known to predict post-traumatic stress disorder (PTSD) after subsequent traumas, it is unclear if this association is limited to cases where the earlier trauma led to PTSD. Resolution of this uncertainty has important implications for research on pre-trauma vulnerability to PTSD. We examined this issue in the WHO World Mental Health (WMH) Surveys with 34,676 respondents who reported lifetime trauma exposure. One lifetime trauma was selected randomly for each respondent. DSM-IV PTSD due to that trauma was assessed. We reported in a previous paper that four earlier traumas involving interpersonal violence significantly predicted PTSD after subsequent random traumas (OR=1.3–2.5). We also assessed 14 lifetime DSM-IV mood, anxiety, disruptive behavior, and substance disorders prior to random traumas. We show in the current report that only prior anxiety disorders significantly predicted PTSD in a multivariate model (OR=1.5–4.3) and that these disorders interacted significantly with three of the earlier traumas (witnessing atrocities, physical violence victimization, rape). History of witnessing atrocities significantly predicted PTSD after subsequent random traumas only among respondents with prior PTSD (OR=5.6). Histories of physical violence victimization (OR=1.5) and rape after age 17 (OR=17.6) significantly predicted only among respondents with no history of prior anxiety disorders. Although only preliminary due to reliance on retrospective reports, these results suggest that history of anxiety disorders and history of a limited number of earlier traumas might usefully be targeted in future prospective studies as distinct foci of research on individual differences in vulnerability to PTSD after subsequent traumas. PMID:28924183

STS-55 Earth observation shows a sunset over South America

NASA Technical Reports Server (NTRS)

1993-01-01

STS-55 Earth observation taken aboard Columbia, Orbiter Vehicle (OV) 102, shows a spectacular sunset view over South America and the cleanest atmosphere since before the volcanic eruptions of 1991, according to NASA scientists studying the STS-55 photography. A dark cloud layer is evident at an altitude of 7 to 9 kilometers. Five kilometers higher, a pink layer of sulfuric acid droplets and ammonium sulfate particles begins at the tropopause and extends upward into the stratosphere to 19 kilometers. Above that, blue scattering by the atmosphere diminishes until, at an altitude of 60 kilometers, the blackness of space is predominant.

Biological consequences of earlier snowmelt from desert dust deposition in alpine landscapes.

PubMed

Steltzer, Heidi; Landry, Chris; Painter, Thomas H; Anderson, Justin; Ayres, Edward

2009-07-14

Dust deposition to mountain snow cover, which has increased since the late 19(th) century, accelerates the rate of snowmelt by increasing the solar radiation absorbed by the snowpack. Snowmelt occurs earlier, but is decoupled from seasonal warming. Climate warming advances the timing of snowmelt and early season phenological events (e.g., the onset of greening and flowering); however, earlier snowmelt without warmer temperatures may have a different effect on phenology. Here, we report the results of a set of snowmelt manipulations in which radiation-absorbing fabric and the addition and removal of dust from the surface of the snowpack advanced or delayed snowmelt in the alpine tundra. These changes in the timing of snowmelt were superimposed on a system where the timing of snowmelt varies with topography and has been affected by increased dust loading. At the community level, phenology exhibited a threshold response to the timing of snowmelt. Greening and flowering were delayed before seasonal warming, after which there was a linear relationship between the date of snowmelt and the timing of phenological events. Consequently, the effects of earlier snowmelt on phenology differed in relation to topography, which resulted in increasing synchronicity in phenology across the alpine landscape with increasingly earlier snowmelt. The consequences of earlier snowmelt from increased dust deposition differ from climate warming and include delayed phenology, leading to synchronized growth and flowering across the landscape and the opportunity for altered species interactions, landscape-scale gene flow via pollination, and nutrient cycling.

The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas.

PubMed

Kessler, R C; Aguilar-Gaxiola, S; Alonso, J; Bromet, E J; Gureje, O; Karam, E G; Koenen, K C; Lee, S; Liu, H; Pennell, B-E; Petukhova, M V; Sampson, N A; Shahly, V; Stein, D J; Atwoli, L; Borges, G; Bunting, B; de Girolamo, G; Gluzman, S F; Haro, J M; Hinkov, H; Kawakami, N; Kovess-Masfety, V; Navarro-Mateu, F; Posada-Villa, J; Scott, K M; Shalev, A Y; Ten Have, M; Torres, Y; Viana, M C; Zaslavsky, A M

2017-09-19

Although earlier trauma exposure is known to predict posttraumatic stress disorder (PTSD) after subsequent traumas, it is unclear whether this association is limited to cases where the earlier trauma led to PTSD. Resolution of this uncertainty has important implications for research on pretrauma vulnerability to PTSD. We examined this issue in the World Health Organization (WHO) World Mental Health (WMH) Surveys with 34 676 respondents who reported lifetime trauma exposure. One lifetime trauma was selected randomly for each respondent. DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) PTSD due to that trauma was assessed. We reported in a previous paper that four earlier traumas involving interpersonal violence significantly predicted PTSD after subsequent random traumas (odds ratio (OR)=1.3-2.5). We also assessed 14 lifetime DSM-IV mood, anxiety, disruptive behavior and substance disorders before random traumas. We show in the current report that only prior anxiety disorders significantly predicted PTSD in a multivariate model (OR=1.5-4.3) and that these disorders interacted significantly with three of the earlier traumas (witnessing atrocities, physical violence victimization and rape). History of witnessing atrocities significantly predicted PTSD after subsequent random traumas only among respondents with prior PTSD (OR=5.6). Histories of physical violence victimization (OR=1.5) and rape after age 17 years (OR=17.6) significantly predicted only among respondents with no history of prior anxiety disorders. Although only preliminary due to reliance on retrospective reports, these results suggest that history of anxiety disorders and history of a limited number of earlier traumas might usefully be targeted in future prospective studies as distinct foci of research on individual differences in vulnerability to PTSD after subsequent traumas.Molecular Psychiatry advance online publication, 19 September 2017; doi:10.1038/mp.2017.194.

Earlier Vegetation Activity Onset Enhances Springtime Water-use Efficiency in Temperate and Boreal Ecosystems

NASA Astrophysics Data System (ADS)

Jin, J.; Wang, Y.

2017-12-01

Ecosystem-scale water-use efficiency (EWUE), defined as the ratio of gross primary productivity (GPP) to evapotranspiration (ET), is an important indicator for understanding how water couples with the carbon cycle under global change. Relationships between EWUE and abiotic environmental factors (e.g. climatic factors, atmospheric CO2concentration and nitrogen deposition) have been widely investigated, but the variations in EWUE in response to biotic controls remain little understood. Here, we argue that phenology plays an important role in the regulation of EWUE by analyzing springtime EWUE responses to variability of the GPP-based vegetation activity onset (VAO) in temperate and boreal ecosystems using both satellite and flux-tower observations. Based on MODIS productions during 2000-2014, we found that spring EWUE widely significantly increased with the earlier VAO mainly in the mid- and high latitudes (over 50°N), southwestern China and mid-western North America. When AVO advanced a 10-day, the spring EWUE would increase on average by 0.17±0.09 g C kg-1 H2O in temperate and continental climates after removing the effect of environmental factors. The main response patterns of EWUE to phenology suggest that an increase in spring EWUE with an earlier VAO are mainly because the increase in GPP is relatively larger in magnitude compared to that of ET, or due to an increase in GPP accompanied by a decrease in ET, resulting from an advanced VAO. The credibility of the results is also supported by the local-scale observations. By analyzing 66 site-years of flux and meteorological data obtained from 8 temperate deciduous broadleaf forest sites across North America and Europe, spring EWUE increased 0.42±0.08 g C kg-1 H2O with a 10-day advance of VAO across all sites after controlling for environmental factors, mainly because an earlier VAO could lead to a steeper increase in GPP than in ET. Our results and conclusions highlight that phenological factors cannot be

Spatial and Temporal Variation in Primary Productivity (NDVI) of Coastal Alaskan Tundra: Decreased Vegetation Growth Following Earlier Snowmelt

NASA Technical Reports Server (NTRS)

Gamon, John A.; Huemmrich, K. Fred; Stone, Robert S.; Tweedie, Craig E.

2015-01-01

In the Arctic, earlier snowmelt and longer growing seasons due to warming have been hypothesized to increase vegetation productivity. Using the Normalized Difference Vegetation Index (NDVI) from both field and satellite measurements as an indicator of vegetation phenology and productivity, we monitored spatial and temporal patterns of vegetation growth for a coastal wet sedge tundra site near Barrow, Alaska over three growing seasons (2000-2002). Contrary to expectation, earlier snowmelt did not lead to increased productivity. Instead, productivity was associated primarily with precipitation and soil moisture, and secondarily with growing degree days, which, during this period, led to reduced growth in years with earlier snowmelt. Additional moisture effects on productivity and species distribution, operating over a longer time scale, were evident in spatial NDVI patterns associated with microtopography. Lower, wetter regions dominated by graminoids were more productive than higher, drier locations having a higher percentage of lichens and mosses, despite the earlier snowmelt at the more elevated sites. These results call into question the oft-stated hypothesis that earlier arctic growing seasons will lead to greater vegetation productivity. Rather, they agree with an emerging body of evidence from recent field studies indicating that early-season, local environmental conditions, notably moisture and temperature, are primary factors determining arctic vegetation productivity. For this coastal arctic site, early growing season conditions are strongly influenced by microtopography, hydrology, and regional sea ice dynamics, and may not be easily predicted from snowmelt date or seasonal average air temperatures alone. Our comparison of field to satellite NDVI also highlights the value of in-situ monitoring of actual vegetation responses using field optical sampling to obtain detailed information on surface conditions not possible from satellite observations alone.

Does Speech Emerge from Earlier Appearing Oral Motor Behaviors?.

ERIC Educational Resources Information Center

Moore, Christopher A.; Ruark, Jacki L.

1996-01-01

This study of the oral motor behaviors of seven toddlers (age 15 months) may be interpreted to indicate that: (1) mandibular coordination follows a developmental continuum from earlier emerging behaviors, such as chewing and sucking, through babbling, to speech, or (2) unique task demands give rise to distinct mandibular coordinative constraints…

Light pollution is associated with earlier tree budburst across the United Kingdom.

PubMed

Ffrench-Constant, Richard H; Somers-Yeates, Robin; Bennie, Jonathan; Economou, Theodoros; Hodgson, David; Spalding, Adrian; McGregor, Peter K

2016-06-29

The ecological impact of night-time lighting is of concern because of its well-demonstrated effects on animal behaviour. However, the potential of light pollution to change plant phenology and its corresponding knock-on effects on associated herbivores are less clear. Here, we test if artificial lighting can advance the timing of budburst in trees. We took a UK-wide 13 year dataset of spatially referenced budburst data from four deciduous tree species and matched it with both satellite imagery of night-time lighting and average spring temperature. We find that budburst occurs up to 7.5 days earlier in brighter areas, with the relationship being more pronounced for later-budding species. Excluding large urban areas from the analysis showed an even more pronounced advance of budburst, confirming that the urban 'heat-island' effect is not the sole cause of earlier urban budburst. Similarly, the advance in budburst across all sites is too large to be explained by increases in temperature alone. This dramatic advance of budburst illustrates the need for further experimental investigation into the impact of artificial night-time lighting on plant phenology and subsequent species interactions. As light pollution is a growing global phenomenon, the findings of this study are likely to be applicable to a wide range of species interactions across the world. © 2016 The Authors.

Earlier Pulmonary Valve Replacement in Down Syndrome Patients Following Tetralogy of Fallot Repair.

PubMed

Sullivan, Rachel T; Frommelt, Peter C; Hill, Garick D

2017-08-01

The association between Down syndrome and pulmonary hypertension could contribute to more severe pulmonary regurgitation after tetralogy of Fallot repair and possibly earlier pulmonary valve replacement. We compared cardiac magnetic resonance measures of pulmonary regurgitation and right ventricular dilation as well as timing of pulmonary valve replacement between those with and without Down syndrome after tetralogy of Fallot repair. Review of our surgical database from 2000 to 2015 identified patients with tetralogy of Fallot with pulmonary stenosis. Those with Down syndrome were compared to those without. The primary outcome of interest was time from repair to pulmonary valve replacement. Secondary outcomes included pulmonary regurgitation and indexed right ventricular volume on cardiac magnetic resonance imaging. The cohort of 284 patients included 35 (12%) with Down syndrome. Transannular patch repair was performed in 210 (74%). Down syndrome showed greater degree of pulmonary regurgitation (55 ± 14 vs. 37 ± 16%, p = 0.01) without a significantly greater rate of right ventricular dilation (p = 0.09). In multivariable analysis, Down syndrome (HR 2.3, 95% CI 1.2-4.5, p = 0.02) and transannular patch repair (HR 5.5, 95% CI 1.7-17.6, p = 0.004) were significant risk factors for valve replacement. Those with Down syndrome had significantly lower freedom from valve replacement (p = 0.03). Down syndrome is associated with an increased degree of pulmonary regurgitation and earlier pulmonary valve replacement after tetralogy of Fallot repair. These patients require earlier assessment by cardiac magnetic resonance imaging to determine timing of pulmonary valve replacement and evaluation for and treatment of preventable causes of pulmonary hypertension.

Later endogenous circadian temperature nadir relative to an earlier wake time in older people

NASA Technical Reports Server (NTRS)

Duffy, J. F.; Dijk, D. J.; Klerman, E. B.; Czeisler, C. A.

1998-01-01

The contribution of the circadian timing system to the age-related advance of sleep-wake timing was investigated in two experiments. In a constant routine protocol, we found that the average wake time and endogenous circadian phase of 44 older subjects were earlier than that of 101 young men. However, the earlier circadian phase of the older subjects actually occurred later relative to their habitual wake time than it did in young men. These results indicate that an age-related advance of circadian phase cannot fully account for the high prevalence of early morning awakening in healthy older people. In a second study, 13 older subjects and 10 young men were scheduled to a 28-h day, such that they were scheduled to sleep at many circadian phases. Self-reported awakening from scheduled sleep episodes and cognitive throughput during the second half of the wake episode varied markedly as a function of circadian phase in both groups. The rising phase of both rhythms was advanced in the older subjects, suggesting an age-related change in the circadian regulation of sleep-wake propensity. We hypothesize that under entrained conditions, these age-related changes in the relationship between circadian phase and wake time are likely associated with self-selected light exposure at an earlier circadian phase. This earlier exposure to light could account for the earlier clock hour to which the endogenous circadian pacemaker is entrained in older people and thereby further increase their propensity to awaken at an even earlier time.

The association between cannabis use and earlier age at onset of schizophrenia and other psychoses: meta-analysis of possible confounding factors.

PubMed

Myles, Nicholas; Newall, Hannah; Nielssen, Olav; Large, Matthew

2012-01-01

A recent meta-analysis showed that the mean age of onset of psychosis among cannabis users was almost three years earlier than that of non-cannabis users. However, because cannabis users usually smoke tobacco, the use of tobacco might independently contribute to the earlier onset of psychosis. We aimed to use meta-analysis to compare the extent to which cannabis and tobacco use are each associated with an earlier age at onset of schizophrenia and other psychoses. We also examined other factors that might have contributed to the finding of an earlier age of onset among cannabis users, including the proportion of males in the samples, the diagnostic inclusion criteria and aspects of study quality. The electronic databases MEDLINE, EMBASE, PsycINFO and ISI Web of Science, were searched for English-language peer-reviewed publications that reported age at onset of schizophrenia and other psychoses separately for cannabis users and non-users, or for tobaccosmokers and non-smokers. Meta-analysis showed that the age at onset of psychosis for cannabis users was 32 months earlier than for cannabis non-users (SMD=- 0.399, 95%CI -0.493 - -0.306, z=-8.34, p < 0.001), and was two weeks later in tobacco smokers compared with non-smokers (SMD=0.002, 95%CI -0.094 - 0.097, z=0.03, p=0.974). The main results were not affected by subgroup analyses examining studies of a single sex, the methods for making psychiatric diagnoses and measures of study quality. The results suggest that the association between cannabis use and earlier onset of psychosis is robust and is not the result either of tobacco smoking by cannabis using patients or the other potentially confounding factors we examined. This supports the hypothesis that, in some patients, cannabis use plays a causal role in the development of schizophrenia and raises the possibility of treating schizophrenia with new pharmacological treatments that have an affinity for endo-cannabinoid receptors.

Reading-Related Skills in Earlier- and Later-Schooled Children

ERIC Educational Resources Information Center

Cunningham, Anna J.; Carroll, Julia M.

2011-01-01

We investigate the effects of age-related factors and formal instruction on the development of reading-related skills in children aged 4 and 7 years. Age effects were determined by comparing two groups of children at the onset of formal schooling; one aged 7 (later-schooled) and one aged 4 (earlier-schooled). Schooling effects were measured by…

Smoking is associated with earlier time to revision of total knee arthroplasty.

PubMed

Lim, Chin Tat; Goodman, Stuart B; Huddleston, James I; Harris, Alex H S; Bhowmick, Subhrojyoti; Maloney, William J; Amanatullah, Derek F

2017-10-01

Smoking is associated with early postoperative complications, increased length of hospital stay, and an increased risk of revision after total knee arthroplasty (TKA). However, the effect of smoking on time to revision TKA is unknown. A total of 619 primary TKAs referred to an academic tertiary center for revision TKA were retrospectively stratified according to the patient smoking status. Smoking status was then analyzed for associations with time to revision TKA using a Chi square test. The association was also analyzed according to the indication for revision TKA. Smokers (37/41, 90%) have an increased risk of earlier revision for any reason compared to non-smokers (274/357, 77%, p=0.031). Smokers (37/41, 90%) have an increased risk of earlier revision for any reason compared to ex-smokers (168/221, 76%, p=0.028). Subgroup analysis did not reveal a difference in indication for revision TKA (p>0.05). Smokers are at increased risk of earlier revision TKA when compared to non-smokers and ex-smokers. The risk for ex-smokers was similar to that of non-smokers. Smoking appears to have an all-or-none effect on earlier revision TKA as patients who smoked more did not have higher risk of early revision TKA. These results highlight the need for clinicians to urge patients not to begin smoking and encourage smokers to quit smoking prior to primary TKA. Copyright © 2017 Elsevier B.V. All rights reserved.

Economic Costs Avoided by Diagnosing Melanoma Six Months Earlier Justify >100 Benign Biopsies.

PubMed

Aires, Daniel J; Wick, Jo; Shaath, Tarek S; Rajpara, Anand N; Patel, Vikas; Badawi, Ahmed H; Li, Cicy; Fraga, Garth R; Doolittle, Gary; Liu, Deede Y

2016-05-01

New melanoma drugs bring enormous benefits but do so at significant costs. Because melanoma grows deeper and deadlier over time, deeper lesions are costlier due to increased sentinel lymph node biopsy, chemotherapy, and disease-associated income loss. Prior studies have justified pigmented lesion biopsies on a "value per life" basis; by contrast we sought to assess how many biopsies are justified per melanoma found on a purely economic basis. We modeled how melanomas in the United States would behave if diagnosis were delayed by 6 months, eg, not biopsied, only observed until the next surveillance visit. Economic loss from delayed biopsy is the obverse of economic benefit of performing biopsy earlier. Growth rates were based on Liu et al. The results of this study can be applied to all patients presenting to dermatologists with pigmented skin lesions suspicious for melanoma. In-situ melanomas were excluded because no studies to date have modeled growth rates analogous to those for invasive melanoma. We assume conservatively that all melanomas not biopsied initially will be biopsied and treated 6 months later. Major modeled costs are (1) increased sentinel lymph node biopsy, (2) increased chemotherapy for metastatic lesions using increased 5-yr death as metastasis marker, and (3) income loss per melanoma death at $413,370 as previously published. Costs avoided by diagnosing melanoma earlier justify 170 biopsies per melanoma found. Efforts to penalize "unnecessary" biopsies may be economically counterproductive.

J Drugs Dermatol. 2016;15(5):527-532.

Floodplains within reservoirs promote earlier spawning of white crappies Pomoxis annularis

USGS Publications Warehouse

Miranda, Leandro E.; Dagel, Jonah D.; Kaczka, Levi J.; Mower, Ethan; Wigen, S. L.

2015-01-01

Reservoirs impounded over floodplain rivers are unique because they may include within their upper reaches extensive shallow water stored over preexistent floodplains. Because of their relatively flat topography and riverine origin, floodplains in the upper reaches of reservoirs provide broad expanses of vegetation within a narrow range of reservoir water levels. Elsewhere in the reservoir, topography creates a band of shallow water along the contour of the reservoir where vegetation often does not grow. Thus, as water levels rise, floodplains may be the first vegetated habitats inundated within the reservoir. We hypothesized that shallow water in reservoir floodplains would attract spawning white crappies Pomoxis annularis earlier than reservoir embayments. Crappie relative abundance over five years in floodplains and embayments of four reservoirs increased as spawning season approached, peaked, and decreased as fish exited shallow water. Relative abundance peaked earlier in floodplains than embayments, and the difference was magnified with higher water levels. Early access to suitable spawning habitat promotes earlier spawning and may increase population fitness. Recognition of the importance of reservoir floodplains, an understanding of how reservoir water levels can be managed to provide timely connectivity to floodplains, and conservation of reservoir floodplains may be focal points of environmental management in reservoirs.

ASCA Observations

NASA Technical Reports Server (NTRS)

Helfand, David J.

1998-01-01

This recently expired grant has supported the work of the PI, his students, and his collaborators on a variety of ASCA projects over the past four years. Annual reports have summarized much of the work accomplished; here we provide a brief review of the work resulting from this effort, and a summary of the personnel who have benefited from the grant's support. Starburst Galaxies with Extreme X-ray Luminosities This project began as a careful examination of the claims of Boller et al. (1992) that there were dozens of "normal" galaxies in the ROSAT All-Sky Survey that had X-ray luminosities in excess of 1042 erg sec, higher than that seen in the hundreds of non-AGN galaxies observed with Einstein. If true, this suggested that X-ray emission associated with star formation activity might have a significant contribution to make to the still unexplained cosmic X-ray background (XRB). Since some of our earlier work with the Einstein Observatory Deep Surveys had suggested a similar possibility and several sets of authors over the years had modelled the starburst XRB contribution, these claims were worth pursuing. Our work expanded the examination beyond the RASS to include earlier claims of high-luminosity galaxies powered by starburst emission (selected in this case on the basis of the far-IR luminosities). The result of extensive followup observations under several programs using ROSAT, ASCA, and ground-based facilities was to show that nearly all of these objects in fact have hidden AGN at their cores, and that their luminosities are not in any way extraordinary.

Comprehensive methods for earlier detection and monitoring of forest decline

Treesearch

Jennifer Pontius; Richard Hallett

2014-01-01

Forested ecosystems are threatened by invasive pests, pathogens, and unusual climatic events brought about by climate change. Earlier detection of incipient forest health problems and a quantitatively rigorous assessment method is increasingly important. Here, we describe a method that is adaptable across tree species and stress agents and practical for use in the...

Earlier nesting by generalist predatory bird is associated with human responses to climate change.

PubMed

Smith, Shawn H; Steenhof, Karen; McClure, Christopher J W; Heath, Julie A

2017-01-01

Warming temperatures cause temporal changes in growing seasons and prey abundance that drive earlier breeding by birds, especially dietary specialists within homogeneous habitat. Less is known about how generalists respond to climate-associated shifts in growing seasons or prey phenology, which may occur at different rates across land cover types. We studied whether breeding phenology of a generalist predator, the American kestrel (Falco sparverius), was associated with shifts in growing seasons and, presumably, prey abundance, in a mosaic of non-irrigated shrub/grasslands and irrigated crops/pastures. We examined the relationship between remotely-sensed normalized difference vegetation index (NDVI) and abundance of small mammals that, with insects, constitute approximately 93% of kestrel diet biomass. We used NDVI to estimate the start of the growing season (SoGS) in irrigated and non-irrigated lands from 1992 to 2015 and tested whether either estimate of annual SoGS predicted the timing of kestrel nesting. Finally, we examined relationships among irrigated SoGS, weather and crop planting. NDVI was a useful proxy for kestrel prey because it predicted small mammal abundance and past studies showed that NDVI predicts insect abundance. NDVI-estimated SoGS advanced significantly in irrigated lands (β = -1·09 ± 0·30 SE) but not in non-irrigated lands (β = -0·57 ± 0·53). Average date of kestrel nesting advanced 15 days in the past 24 years and was positively associated with the SoGS in irrigated lands, but not the SoGS in non-irrigated lands. Advanced SoGS in irrigated lands was related to earlier planting of crops after relatively warm winters, which were more common in recent years. Despite different patterns of SoGS change between land cover types, kestrel nesting phenology shifted with earlier prey availability in irrigated lands. Kestrels may preferentially track prey in irrigated lands over non-irrigated lands because of higher quality prey on

Earlier Violent Television Exposure and Later Drug Dependence

PubMed Central

Brook, David W.; Katten, Naomi S.; Ning, Yuming; Brook, Judith S.

2013-01-01

This research examined the longitudinal pathways from earlier violent television exposure to later drug dependence. African American and Puerto Rican adolescents were interviewed during three points in time (N = 463). Violent television exposure in late adolescence predicted violent television exposure in young adulthood, which in turn was related to tobacco/marijuana use, nicotine dependence, and later drug dependence. Some policy and clinical implications suggest: a) regulating the times when violent television is broadcast; b) creating developmentally targeted prevention/treatment programs; and c) recognizing that watching violent television may serve as a cue regarding increased susceptibility to nicotine and drug dependence. PMID:18612881

Observation of Night OH in the Mesosphere

NASA Technical Reports Server (NTRS)

Pickett, H. M.; Read, W. G.; Lee, K. K.; Yung, Y. L.

2006-01-01

Satellite measurements from the Aura MLS instrument show a layer of OH near 82 km in the night. This layer confirms earlier measurements by ground-based LIDAR. The MLS and LIDAR observations measure OH in the lowest vibrational state and are distinct, but related chemically, from vibrationally-excited emission from the OH Meinel bands in the near infrared. The Caltech 1-D model has been extended to include vibrational dependence of OH reactions and shows good agreement with MLS OH data and with observations of the Meinel bands. The model shows a chemical lifetime of HO(x) that increases from less than a day at 80 km to over a month at 87 km. Above this altitude transport processes become an important part of HOx chemistry. The model predicts that ground state OH represents 99% of the total OH up to 84 km.

To achieve an earlier IFN-γ response is not sufficient to control Mycobacterium tuberculosis infection in mice.

PubMed

Vilaplana, Cristina; Prats, Clara; Marzo, Elena; Barril, Carles; Vegué, Marina; Diaz, Jorge; Valls, Joaquim; López, Daniel; Cardona, Pere-Joan

2014-01-01

The temporo-spatial relationship between the three organs (lung, spleen and lymph node) involved during the initial stages of Mycobacterium tuberculosis infection has been poorly studied. As such, we performed an experimental study to evaluate the bacillary load in each organ after aerosol or intravenous infection and developed a mathematical approach using the data obtained in order to extract conclusions. The results showed that higher bacillary doses result in an earlier IFN-γ response, that a certain bacillary load (BL) needs to be reached to trigger the IFN-γ response, and that control of the BL is not immediate after onset of the IFN-γ response, which might be a consequence of the spatial dimension. This study may have an important impact when it comes to designing new vaccine candidates as it suggests that triggering an earlier IFN-γ response might not guarantee good infection control, and therefore that additional properties should be considered for these candidates.

To Achieve an Earlier IFN-γ Response Is Not Sufficient to Control Mycobacterium tuberculosis Infection in Mice

PubMed Central

Marzo, Elena; Barril, Carles; Vegué, Marina; Diaz, Jorge; Valls, Joaquim; López, Daniel; Cardona, Pere-Joan

2014-01-01

The temporo-spatial relationship between the three organs (lung, spleen and lymph node) involved during the initial stages of Mycobacterium tuberculosis infection has been poorly studied. As such, we performed an experimental study to evaluate the bacillary load in each organ after aerosol or intravenous infection and developed a mathematical approach using the data obtained in order to extract conclusions. The results showed that higher bacillary doses result in an earlier IFN-γ response, that a certain bacillary load (BL) needs to be reached to trigger the IFN-γ response, and that control of the BL is not immediate after onset of the IFN-γ response, which might be a consequence of the spatial dimension. This study may have an important impact when it comes to designing new vaccine candidates as it suggests that triggering an earlier IFN-γ response might not guarantee good infection control, and therefore that additional properties should be considered for these candidates. PMID:24959669

Statistical analysis of dynamic fibrils observed from NST/BBSO observations

NASA Astrophysics Data System (ADS)

Gopalan Priya, Thambaje; Su, Jiang-Tao; Chen, Jie; Deng, Yuan-Yong; Prasad Choudhury, Debi

2018-02-01

We present the results obtained from the analysis of dynamic fibrils in NOAA active region (AR) 12132, using high resolution Hα observations from the New Solar Telescope operating at Big Bear Solar Observatory. The dynamic fibrils are seen to be moving up and down, and most of these dynamic fibrils are periodic and have a jet-like appearance. We found from our observations that the fibrils follow almost perfect parabolic paths in many cases. A statistical analysis on the properties of the parabolic paths showing an analysis on deceleration, maximum velocity, duration and kinetic energy of these fibrils is presented here. We found the average maximum velocity to be around 15 kms‑1 and mean deceleration to be around 100 ms‑2. The observed deceleration appears to be a fraction of gravity of the Sun and is not compatible with the path of ballistic motion due to gravity of the Sun. We found a positive correlation between deceleration and maximum velocity. This correlation is consistent with simulations done earlier on magnetoacoustic shock waves propagating upward.

Identifying pneumonia outbreaks of public health importance: can emergency department data assist in earlier identification?

PubMed

Hope, Kirsty; Durrheim, David N; Muscatello, David; Merritt, Tony; Zheng, Wei; Massey, Peter; Cashman, Patrick; Eastwood, Keith

2008-08-01

To retrospectively review the performance of a near real-time Emergency Department (ED) Syndromic Surveillance System operating in New South Wales for identifying pneumonia outbreaks of public health importance. Retrospective data was obtained from the NSW Emergency Department data collection for a rural hospital that has experienced a cluster of pneumonia diagnoses among teenage males in August 2006. ED standard reports were examined for signals in the overall count for each respiratory syndrome, and for elevated counts in individual subgroups including; age, sex and admission to hospital status. Using the current thresholds, the ED syndromic surveillance system would have trigged a signal for pneumonia syndrome in children aged 5-16 years four days earlier than the notification by a paediatrician and this signal was maintained for 14 days. If the ED syndromic surveillance system had been operating it could have identified the outbreak earlier than the paediatrician's notification. This may have permitted an earlier public health response. By understanding the behaviour of syndromes during outbreaks of public health importance, response protocols could be developed to facilitate earlier implementation of control measures.

Changes toward earlier streamflow timing across western North America

USGS Publications Warehouse

Stewart, I.T.; Cayan, D.R.; Dettinger, M.D.

2005-01-01

The highly variable timing of streamflow in snowmelt-dominated basins across western North America is an important consequence, and indicator, of climate fluctuations. Changes in the timing of snowmelt-derived streamflow from 1948 to 2002 were investigated in a network of 302 western North America gauges by examining the center of mass for flow, spring pulse onset dates, and seasonal fractional flows through trend and principal component analyses. Statistical analysis of the streamflow timing measures with Pacific climate indicators identified local and key large-scale processes that govern the regionally coherent parts of the changes and their relative importance. Widespread and regionally coherent trends toward earlier onsets of springtime snowmelt and streamflow have taken place across most of western North America, affecting an area that is much larger than previously recognized. These timing changes have resulted in increasing fractions of annual flow occurring earlier in the water year by 1-4 weeks. The immediate (or proximal) forcings for the spatially coherent parts of the year-to-year fluctuations and longer-term trends of streamflow timing have been higher winter and spring temperatures. Although these temperature changes are partly controlled by the decadal-scale Pacific climate mode [Pacific decadal oscillation (PDO)], a separate and significant part of the variance is associated with a springtime warming trend that spans the PDO phases. ?? 2005 American Meteorological Society.

Earlier flowering did not alter pollen limitation in an early flowering shrub under short-term experimental warming.

PubMed

Pan, Cheng-Chen; Feng, Qi; Zhao, Ha-Lin; Liu, Lin-De; Li, Yu-Lin; Li, Yu-Qiang; Zhang, Tong-Hui; Yu, Xiao-Ya

2017-06-05

In animal pollinated plants, phenological shifts caused by climate change may have important ecological consequences. However, no empirical evidence exists at present on the consequences that flowering phenology shifts have on the strength of pollen limitation under experimental warming. Here, we investigated the effects of experimental warming on flowering phenology, flower density, reproductive success, and pollen limitation intensity in Caragana microphylla and evaluated whether earlier flowering phenology affected plant reproduction and the level of pollen limitation using warmed and unwarmed open top chambers in the Horqin Sandy Land of Inner Mongolia, northern China. The results of this study indicated that artificial warming markedly advanced flower phenology rather than extending the duration of the flowering. Additionally, warming was found to significantly reduce flower density which led to seed production reduction, since there were insignificant effects observed on fruit set and seed number per fruit. Experimental floral manipulations showed that warming did not affect pollen limitation. These results revealed the negative effects of advanced phenology induced by warming on flower density and reproductive output, as well as the neutral effects on reproductive success and pollen limitation intensity of long surviving plants.

Initial Steps in Creating a Developmentally Valid Tool for Observing/Assessing Rope Jumping

ERIC Educational Resources Information Center

Roberton, Mary Ann; Thompson, Gregory; Langendorfer, Stephen J.

2017-01-01

Background: Valid motor development sequences show the various behaviors that children display as they progress toward competence in specific motor skills. Teachers can use these sequences to observe informally or formally assess their students. While longitudinal study is ultimately required to validate developmental sequences, there are earlier,…

Detectability of electrostatic decay products in Ulysses and Galileo observations of type 3 solar radio sources

NASA Technical Reports Server (NTRS)

Cairns, Iver H.

1995-01-01

Recent in situ Ulysses and Galileo observations of the source regions of type 3 solar radio bursts appear to show an absence of ion acoustic waves S produced by nonlinear Langmuir wave processes such as the electrostatic (ES) decay, in contradiction with earlier ISEE 3 observations and analytic theory. This letter resolves these apparent contradictions. Refined analyses of the maximum S-wave electric fields produced by ES decay and of the characteristics of the Ulysses Wave Form Analyzer (WFA) instrument show that the bursty S waves observed by the ISEE 3 should be essentially undetectable by the Ulysses WFA. It is also shown that the maximum S-wave levels predicted for the Galileo event are approximately less than the instrumental noise level, thereby confirming an earlier suggestion. Thus, no contradictions exist between the ISEE 3 and Ulysses/Galileo observation, and no evidence exists against ES decay in the published Ulysses and Galileo data. All available data are consistent with, or at worst not inconsistent with, the ES decay proceeding and being the dominant nonlinear process in type 3 bursts.

THEMIS Observations of Mars Aerosol Optical Depth from 2002-2008

NASA Technical Reports Server (NTRS)

Smith, Michael D.

2009-01-01

We use infrared images obtained by the Thermal Emission Imaging System (THEMIS) instrument on-board Mars Odyssey to retrieve the optical depth of dust and water ice aerosols over more than 3.5 martian years between February 2002 (MY 25, Ls=330 ) and December 2008 (MY 29, Ls=183). These data provide an important bridge between earlier TES observations and recent observations from Mars Express and Mars Reconnaissance Orbiter. An improvement to our earlier retrieval to include atmospheric temperature information from THEMIS Band 10 observations leads to much improved retrievals during the largest dust storms. The new retrievals show moderate dust storm activity during Mars Years 26 and 27, although details of the strength and timing of dust storms is different from year to year. A planet-encircling dust storm event was observed during Mars Year 28 near Southern Hemisphere Summer solstice. A belt of low-latitude water ice clouds was observed during the aphelion season during each year, Mars Years 26 through 29. The optical depth of water ice clouds is somewhat higher in the THEMIS retrievals at approximately 5:00 PM local time than in the TES retrievals at approximately 2:00 PM, suggestive of possible local time variation of clouds.

STS-44 Earth observation shows purplish twilight over the Atlantic Ocean

NASA Technical Reports Server (NTRS)

1991-01-01

STS-44 Earth observation taken aboard Atlantis, Orbiter Vehicle (OV) 104, shows twilight over the Atlantic Ocean. OV-104 was at a point in the north Atlantic located at 28 degrees north latitude and 37 degrees west longitude. The spacecraft has just passed sundown on the Earth's surface, but it was still daylight at an altitude of 195 nautical miles. During the mission, the astronauts noted that the limb of the Earth displayed a more purplish tint instead of its normal blue. This effect, according to NASA scientists, is attributed to the high altitude residue (mostly sulfuric acid particles) from the Mount Pinatubo eruptions of mid June 1991. Note the broad band of twilight in the center of the image. This band is another indicator of the upper atmospheric scattering of sunlight caused by this layer of haze that exists between 20 and 30 kilometers above Earth. Sunlight highlights the empty payload bay (PLB), the vertical tail, and orbital maneuvering system (OMS) pods against the black

Do emotional support and classroom organization earlier in the year set the stage for higher quality instruction?

PubMed

Curby, Timothy W; Rimm-Kaufman, Sara E; Abry, Tashia

2013-10-01

Many teachers believe that providing greater emotional and organizational supports in the beginning of the year strengthens their ability to teach effectively as the year progresses. Some interventions, such as the Responsive Classroom (RC) approach, explicitly embed this sequence into professional development efforts. We tested the hypothesis that earlier emotional and organizational supports set the stage for improved instruction later in the year in a sample of third- and fourth-grade teachers enrolled in a randomized controlled trial of the RC approach. Further, we examined the extent to which the model generalized for teachers using varying levels of RC practices as well as whether or not teachers were in the intervention or control groups. Teachers' emotional, organizational, and instructional interactions were observed using the Classroom Assessment Scoring System (Pianta, La Paro, & Hamre, 2008) on five occasions throughout the year. Results indicated a reciprocal relation between emotional and instructional supports. Specifically, higher levels of emotional support earlier in the year predicted higher instructional support later in the year. Also, higher levels of instructional support earlier in the year predicted higher emotional support later in the year. Classroom organization was not found to have longitudinal associations with the other domains across a year. This pattern was robust when controlling for the use of RC practices as well as across intervention and control groups. Further, teachers' use of RC practices predicted higher emotional support and classroom organization throughout the year, suggesting the malleability of this teacher characteristic. Discussion highlights the connection between teachers' emotional and instructional supports and how the use of RC practices improves teachers' emotionally supportive interactions with students. Copyright © 2013 Society for the Study of School Psychology. Published by Elsevier Ltd. All rights

A herbicide-resistant ACCase 1781 Setaria mutant shows higher fitness than wild type.

PubMed

Wang, T; Picard, J C; Tian, X; Darmency, H

2010-10-01

It is often alleged that mutations conferring herbicide resistance have a negative impact on plant fitness. A mutant ACCase1781 allele endowing resistance to the sethoxydim herbicide was introgressed from a resistant green foxtail (Setaria viridis (L.) Beauv) population into foxtail millet (S. italica (L.) Beauv.). (1) Better and earlier growth of resistant plants was observed in a greenhouse cabinet. (2) Resistant plants of the advanced BC7 backcross generation showed more vigorous juvenile growth in the field, earlier flowering, more tillers and higher numbers of grains than susceptible plants did, especially when both genotypes were grown in mixture, but their seeds were lighter than susceptible seeds. (3) Field populations originating from segregating hybrids had the expected allele frequencies under normal growth conditions, but showed a genotype shift toward an excess of homozygous resistant plants within 3 years in stressful conditions. Lower seed size, lower germination rate and perhaps unexplored differences in seed longevity and predation could explain how the resistant plants have the same field fitness over the whole life cycle as the susceptible ones although they produce more seeds. More rapid growth kinetics probably accounted for higher fitness of the resistant plants in adverse conditions. The likelihood of a linkage with a beneficial gene is discussed versus the hypothesis of a pleiotropic effect of the ACCase resistance allele. It is suggested that autogamous species like Setaria could not develop a resistant population without the help of a linkage with a gene producing a higher fitness.

Discharging patients earlier in the day: a concept worth evaluating.

PubMed

Kravet, Steven J; Levine, Rachel B; Rubin, Haya R; Wright, Scott M

2007-01-01

Patient discharges from the hospital often occur late in the day and are frequently clustered after 4 PM. When inpatients leave earlier in the day, quality is improved because new admissions awaiting beds are able to leave the emergency department sooner and emergency department waiting room backlog is reduced. Nursing staff, whose work patterns traditionally result in high activity of discharge and admission between 5 PM and 8 PM, benefit by spreading out their work across a longer part of the day. Discharging patients earlier in the day also has the potential to increase patient satisfaction. Despite multiple stakeholders in the discharge planning process, physicians play the most important role. Getting physician buy-in requires an ability to teach physicians about the concept of early-in-the-day discharges and their impact on the process. We defined a new physician-centered discharge planning process and introduced it to an internal medicine team with an identical control team as a comparison. Discharge time of day was analyzed for 1 month. Mean time of day of discharge was 13:39 for the intervention group versus 15:45 for the control group (P<.001). If reproduced successfully, this process could improve quality at an important transition point in patient care.

Earlier occurrence and increased explanatory power of climate for the first incidence of potato late blight caused by Phytophthora infestans in Fennoscandia.

PubMed

Lehsten, Veiko; Wiik, Lars; Hannukkala, Asko; Andreasson, Erik; Chen, Deliang; Ou, Tinghai; Liljeroth, Erland; Lankinen, Åsa; Grenville-Briggs, Laura

2017-01-01

Late blight (caused by Phytophthora infestans) is a devastating potato disease that has been found to occur earlier in the season over the last decades in Fennoscandia. Up until now the reasons for this change have not been investigated. Possible explanations for this change are climate alterations, changes in potato production or changes in pathogen biology, such as increased fitness or changes in gene flow within P. infestans populations. The first incidence of late blight is of high economic importance since fungicidal applications should be typically applied two weeks before the first signs of late blight and are repeated on average once a week. We use field observations of first incidence of late blight in experimental potato fields from five sites in Sweden and Finland covering a total of 30 years and investigate whether the earlier incidence of late blight can be related to the climate. We linked the field data to meteorological data and found that the previous assumption, used in common late blight models, that the disease only develops at relative humidity levels above 90% had to be rejected. Rather than the typically assumed threshold relationship between late blight disease development and relative humidity we found a linear relationship. Our model furthermore showed two distinct responses of late blight to climate. At the beginning of the observation time (in Sweden until the early 90s and in Finland until the 2000s) the link between climate and first incidence was very weak. However, for the remainder of the time period the link was highly significant, indicating a change in the biological properties of the pathogen which could for example be a change in the dominating reproduction mode or a physiological change in the response of the pathogen to climate. The study shows that models used in decision support systems need to be checked and re-parametrized regularly to be able to capture changes in pathogen biology. While this study was performed with

STOCK YARD LOOKING SOUTHEAST SHOWING OVERHEAD YARD CRANE RAIL, THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

STOCK YARD LOOKING SOUTHEAST SHOWING OVERHEAD YARD CRANE RAIL, THE MALLEABLE CUPOLAS AND EMISSION RECOVERY SYSTEM, OLD SHED ROOF THAT COVERED THE EARLIER MALLEABLE CUPOLA CHARGING CRANE, MALLEABLE FOUNDRY, AND POLLUTION CONTROL BAGHOUSE. - Stockham Pipe & Fittings Company, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

Traumatic Brain Injury History is Associated with Earlier Age of Onset of Alzheimer Disease

PubMed Central

LoBue, Christian; Wadsworth, Hannah; Wilmoth, Kristin; Clem, Matthew; Hart, John; Womack, Kyle B.; Didehbani, Nyaz; Lacritz, Laura H.; Rossetti, Heidi C.; Cullum, C. Munro

2016-01-01

Objective This study examined whether a history of traumatic brain injury (TBI) is associated with earlier onset of Alzheimer disease (AD), independent of apolipoprotein ε4 status (Apoe4) and gender. Method Participants with a clinical diagnosis of AD (n=7625) were obtained from the National Alzheimer’s Coordinating Center Uniform Data Set, and categorized based on self-reported lifetime TBI with loss of consciousness (LOC) (TBI+ vs TBI-) and presence of Apoe4. ANCOVAs, controlling for gender, race, and education were used to examine the association between history of TBI, presence of Apoe4, and an interaction of both risk factors on estimated age of AD onset. Results Estimated AD onset differed by TBI history and Apoe4 independently (p’s <.001). The TBI+ group had a mean age of onset 2.5 years earlier than the TBI- group. Likewise, Apoe4 carriers had a mean age of onset 2.3 years earlier than non-carriers. While the interaction was non-significant (p = .34), participants having both a history of TBI and Apoe4 had the earliest mean age of onset compared to those with a TBI history or Apoe4 alone (MDifference = 2.8 & 2.7 years, respectively). These results remained unchanged when stratified by gender. Conclusions History of self-reported TBI can be associated with an earlier onset of AD-related cognitive decline, regardless of Apoe4 status and gender. TBI may be related to an underlying neurodegenerative process in AD, but the implications of age at time of injury, severity, and repetitive injuries remain unclear. PMID:27855547

Field evidence for earlier leaf-out dates in alpine grassland on the eastern Tibetan Plateau from 1990 to 2006.

PubMed

Zhou, H K; Yao, B Q; Xu, W X; Ye, X; Fu, J J; Jin, Y X; Zhao, X Q

2014-08-01

Worldwide, many plant species are experiencing an earlier onset of spring phenophases due to climate warming. Rapid recent temperature increases on the Tibetan Plateau (TP) have triggered changes in the spring phenology of the local vegetation. However, remote sensing studies of the land surface phenology have reached conflicting interpretations about green-up patterns observed on the TP since the mid-1990s. We investigated this issue using field phenological observations from 1990 to 2006, for 11 dominant plants on the TP at the levels of species, families (Gramineae-grasses and Cyperaceae-sedges) and vegetation communities (alpine meadow and alpine steppe). We found a significant trend of earlier leaf-out dates for one species (Koeleria cristata). The leaf-out dates of both Gramineae and Cyperaceae had advanced (the latter significantly, starting an average of 9 days later per year than the former), but the correlation between them was significant. The leaf-out dates of both vegetation communities also advanced, but the pattern was only significant in the alpine meadow. This study provides the first field evidence of advancement in spring leaf phenology on the TP and suggests that the phenology of the alpine steppe can differ from that of the alpine meadow. These findings will be useful for understanding ecosystem responses to climate change and for grassland management on the TP. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

Association between severe dorsolateral prefrontal dysfunction during random number generation and earlier onset in schizophrenia.

PubMed

Koike, Shinsuke; Takizawa, Ryu; Nishimura, Yukika; Marumo, Kohei; Kinou, Masaru; Kawakubo, Yuki; Rogers, Mark A; Kasai, Kiyoto

2011-08-01

Schizophrenia involves impairment in attention, working memory and executive processes associated with prefrontal cortical function, an essential contributor of social functioning. Age at onset is a major factor for predicting social outcome in schizophrenia. In clinical settings, we need an objective assessment tool for evaluating prefrontal function and social outcome. Participants included 22 right-handed patients with schizophrenia and 40 gender- and age-matched healthy controls. We used a 52-channel near-infrared spectroscopy (NIRS) instrument to measure oxygenated haemoglobin ([oxy-Hb]) changes over the prefrontal cortex during a random number generation (RNG) task. In healthy controls, we found significant [oxy-Hb] increase in the bilateral dorsolateral (DLPFC; BA9 and BA46) and ventrolateral prefrontal cortex (VLPFC; BA44, 45 and 47). The patients with schizophrenia showed significantly smaller activation than the healthy controls in the same approximate regions. In the patient group, a smaller [oxy-Hb] increase in the right DLPFC region (BA9) was significantly correlated with earlier age at onset. NIRS can detect prefrontal cortical dysfunction associated with an executive task, which was coupled with earlier age at onset in schizophrenia. Multichannel NIRS, a non-invasive and user-friendly instrument, may be useful in evaluating cognitive function and social outcome in clinical settings in psychiatry. Copyright © 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Integrated Tree-Ring-Radiocarbon High-Resolution Timeframe to Resolve Earlier Second Millennium BCE Mesopotamian Chronology.

PubMed

Manning, Sturt W; Griggs, Carol B; Lorentzen, Brita; Barjamovic, Gojko; Ramsey, Christopher Bronk; Kromer, Bernd; Wild, Eva Maria

2016-01-01

500 years of ancient Near Eastern history from the earlier second millennium BCE, including such pivotal figures as Hammurabi of Babylon, Šamši-Adad I (who conquered Aššur) and Zimrilim of Mari, has long floated in calendar time subject to rival chronological schemes up to 150+ years apart. Texts preserved on clay tablets provide much information, including some astronomical references, but despite 100+ years of scholarly effort, chronological resolution has proved impossible. Documents linked with specific Assyrian officials and rulers have been found and associated with archaeological wood samples at Kültepe and Acemhöyük in Turkey, and offer the potential to resolve this long-running problem. Here we show that previous work using tree-ring dating to place these timbers in absolute time has fundamental problems with key dendrochronological crossdates due to small sample numbers in overlapping years and insufficient critical assessment. To address, we have integrated secure dendrochronological sequences directly with radiocarbon (14C) measurements to achieve tightly resolved absolute (calendar) chronological associations and identify the secure links of this tree-ring chronology with the archaeological-historical evidence. The revised tree-ring-sequenced 14C time-series for Kültepe and Acemhöyük is compatible only with the so-called Middle Chronology and not with the rival High, Low or New Chronologies. This finding provides a robust resolution to a century of uncertainty in Mesopotamian chronology and scholarship, and a secure basis for construction of a coherent timeframe and history across the Near East and East Mediterranean in the earlier second millennium BCE. Our re-dating also affects an unusual tree-ring growth anomaly in wood from Porsuk, Turkey, previously tentatively associated with the Minoan eruption of the Santorini volcano. This tree-ring growth anomaly is now directly dated ~1681-1673 BCE (68.2% highest posterior density range), ~20

Integrated Tree-Ring-Radiocarbon High-Resolution Timeframe to Resolve Earlier Second Millennium BCE Mesopotamian Chronology

PubMed Central

Griggs, Carol B.; Lorentzen, Brita; Barjamovic, Gojko; Ramsey, Christopher Bronk; Kromer, Bernd; Wild, Eva Maria

2016-01-01

500 years of ancient Near Eastern history from the earlier second millennium BCE, including such pivotal figures as Hammurabi of Babylon, Šamši-Adad I (who conquered Aššur) and Zimrilim of Mari, has long floated in calendar time subject to rival chronological schemes up to 150+ years apart. Texts preserved on clay tablets provide much information, including some astronomical references, but despite 100+ years of scholarly effort, chronological resolution has proved impossible. Documents linked with specific Assyrian officials and rulers have been found and associated with archaeological wood samples at Kültepe and Acemhöyük in Turkey, and offer the potential to resolve this long-running problem. Here we show that previous work using tree-ring dating to place these timbers in absolute time has fundamental problems with key dendrochronological crossdates due to small sample numbers in overlapping years and insufficient critical assessment. To address, we have integrated secure dendrochronological sequences directly with radiocarbon (14C) measurements to achieve tightly resolved absolute (calendar) chronological associations and identify the secure links of this tree-ring chronology with the archaeological-historical evidence. The revised tree-ring-sequenced 14C time-series for Kültepe and Acemhöyük is compatible only with the so-called Middle Chronology and not with the rival High, Low or New Chronologies. This finding provides a robust resolution to a century of uncertainty in Mesopotamian chronology and scholarship, and a secure basis for construction of a coherent timeframe and history across the Near East and East Mediterranean in the earlier second millennium BCE. Our re-dating also affects an unusual tree-ring growth anomaly in wood from Porsuk, Turkey, previously tentatively associated with the Minoan eruption of the Santorini volcano. This tree-ring growth anomaly is now directly dated ~1681–1673 BCE (68.2% highest posterior density range), ~20

Diffusion measurement from observed transverse beam echoes

DOE PAGES

Sen, Tanaji; Fischer, Wolfram

2017-01-09

For this research, we study the measurement of transverse diffusion through beam echoes. We revisit earlier observations of echoes in RHIC and apply an updated theoretical model to these measurements. We consider three possible models for the diffusion coefficient and show that only one is consistent with measured echo amplitudes and pulse widths. This model allows us to parameterize the diffusion coefficients as functions of bunch charge. We demonstrate that echoes can be used to measure diffusion much quicker than present methods and could be useful to a variety of hadron synchrotrons.

Empirical corroboration of an earlier theoretical resolution to the UV paradox of insect polarized skylight orientation.

PubMed

Wang, Xin; Gao, Jun; Fan, Zhiguo

2014-02-01

It is surprising that many insect species use only the ultraviolet (UV) component of the polarized skylight for orientation and navigation purposes, while both the intensity and the degree of polarization of light from the clear sky are lower in the UV than at longer (blue, green, red) wavelengths. Why have these insects chosen the UV part of the polarized skylight? This strange phenomenon is called the "UV-sky-pol paradox". Although earlier several speculations tried to resolve this paradox, they did this without any quantitative data. A theoretical and computational model has convincingly explained why it is advantageous for certain animals to detect celestial polarization in the UV. We performed a sky-polarimetric approach and built a polarized skylight sensor that models the processing of polarization signals by insect photoreceptors. Using this model sensor, we carried out measurements under clear and cloudy sky conditions. Our results showed that light from the cloudy sky has maximal degree of polarization in the UV. Furthermore, under both clear and cloudy skies the angle of polarization of skylight can be detected with a higher accuracy. By this, we corroborated empirically the soundness of the earlier computational resolution of the UV-sky-pol paradox.

Empirical corroboration of an earlier theoretical resolution to the UV paradox of insect polarized skylight orientation

NASA Astrophysics Data System (ADS)

Wang, Xin; Gao, Jun; Fan, Zhiguo

2014-02-01

It is surprising that many insect species use only the ultraviolet (UV) component of the polarized skylight for orientation and navigation purposes, while both the intensity and the degree of polarization of light from the clear sky are lower in the UV than at longer (blue, green, red) wavelengths. Why have these insects chosen the UV part of the polarized skylight? This strange phenomenon is called the "UV-sky-pol paradox". Although earlier several speculations tried to resolve this paradox, they did this without any quantitative data. A theoretical and computational model has convincingly explained why it is advantageous for certain animals to detect celestial polarization in the UV. We performed a sky-polarimetric approach and built a polarized skylight sensor that models the processing of polarization signals by insect photoreceptors. Using this model sensor, we carried out measurements under clear and cloudy sky conditions. Our results showed that light from the cloudy sky has maximal degree of polarization in the UV. Furthermore, under both clear and cloudy skies the angle of polarization of skylight can be detected with a higher accuracy. By this, we corroborated empirically the soundness of the earlier computational resolution of the UV-sky-pol paradox.

An earlier age of breast cancer diagnosis related to more frequent use of antiperspirants/deodorants and underarm shaving.

PubMed

McGrath, K G

2003-12-01

Breast cancer incidence suggests a lifestyle cause. A lifestyle factor used near the breast is the application of antiperspirants/deodorants accompanied by axillary shaving. A previous study did not support a link with breast cancer. If these habits have a role in breast cancer development, women using antiperspirants/deodorants and shaving their underarms frequently would be expected to have an earlier age of diagnosis than those doing so less often. An earlier age of diagnosis would also be expected in those starting to use deodorants and shaving at an earlier age. This is the first study to investigate the intensity of underarm exposure in a cohort of breast cancer survivors. Four hundred and thirty-seven females diagnosed with breast cancer were surveyed. Once grouped by their frequency of underarm hygiene habits, the mean age of diagnosis was the primary end point. Secondary end points included the overall frequency of these habits, and potential usage group confounding variables were evaluated. All statistical tests were two-sided. Frequency and earlier onset of antiperspirant/deodorant usage with underarm shaving were associated with an earlier age of breast cancer diagnosis. Combined habits are likely for this earlier age of diagnosis. In conclusion, underarm shaving with antiperspirant/deodorant use may play a role in breast cancer. It is not clear which of these components are involved. Reviewed literature insinuates absorption of aluminium salts facilitated by dermal barrier disruption. Case-controlled investigations are needed before alternative underarm hygiene habits are suggested.

Childhood hair product use and earlier age at menarche in a racially diverse study population: a pilot study.

PubMed

James-Todd, Tamarra; Terry, Mary Beth; Rich-Edwards, Janet; Deierlein, Andrea; Senie, Ruby

2011-06-01

Previous studies suggest that hair products containing endocrine disrupting chemicals could alter puberty. We evaluated the association between childhood hair product use and age at menarche in a racially diverse study population. We recruited 300 African-American, African-Caribbean, Hispanic, and white women from the New York City metropolitan area who were between 18-77 years of age. Data were collected retrospectively on hair oil, lotion, leave-in conditioner, perm, and other types of hair products used before age 13. Recalled age at menarche ranged from 8 to 19 years. We used multivariable binomial regression to evaluate the association between hair product use and age at menarche (<12 vs. ≥12), adjusting for potential confounders. African-Americans were more likely to use hair products and reached menarche earlier than other racial/ethnic groups. Women reporting childhood hair oil use had a risk ratio of 1.4 (95% confidence interval [CI]: 1.1-1.9) for earlier menarche, adjusting for race/ethnicity and year of birth. Hair perm users had an increased risk for earlier menarche (adjusted risk ratio = 1.4, 95% CI: 1.1-1.8). Other types of hair products assessed in this study were not associated with earlier menarche. Childhood hair oil and perm use were associated with earlier menarche. If replicated, these results suggest that hair product use may be important to measure in evaluating earlier age at menarche. Copyright © 2011 Elsevier Inc. All rights reserved.

Detection, attribution, and sensitivity of trends toward earlier streamflow in the Sierra Nevada

USGS Publications Warehouse

Maurer, E.P.; Stewart, I.T.; Bonfils, Celine; Duffy, P.B.; Cayan, D.

2007-01-01

Observed changes in the timing of snowmelt dominated streamflow in the western United States are often linked to anthropogenic or other external causes. We assess whether observed streamflow timing changes can be statistically attributed to external forcing, or whether they still lie within the bounds of natural (internal) variability for four large Sierra Nevada (CA) basins, at inflow points to major reservoirs. Streamflow timing is measured by "center timing" (CT), the day when half the annual flow has passed a given point. We use a physically based hydrology model driven by meteorological input from a global climate model to quantify the natural variability in CT trends. Estimated 50-year trends in CT due to natural climate variability often exceed estimated actual CT trends from 1950 to 1999. Thus, although observed trends in CT to date may be statistically significant, they cannot yet be statistically attributed to external influences on climate. We estimate that projected CT changes at the four major reservoir inflows will, with 90% confidence, exceed those from natural variability within 1-4 decades or 4-8 decades, depending on rates of future greenhouse gas emissions. To identify areas most likely to exhibit CT changes in response to rising temperatures, we calculate changes in CT under temperature increases from 1 to 5??. We find that areas with average winter temperatures between -2??C and -4??C are most likely to respond with significant CT shifts. Correspondingly, elevations from 2000 to 2800 in are most sensitive to temperature increases, with CT changes exceeding 45 days (earlier) relative to 1961-1990. Copyright 2007 by the American Geophysical Union.

Diagnosis of varicoceles in men undergoing vasectomy may lead to earlier detection of hypogonadism.

PubMed

Liu, Joceline S; Jones, Madeline; Casey, Jessica T; Fuchs, Amanda B; Cashy, John; Lin, William W

2014-06-01

To determine the temporal relationship between vasectomy, varicocele, and hypogonadism diagnosis. Many young men undergo their first thorough genitourinary examination in their adult lives at the time of vasectomy consultation, providing a unique opportunity for diagnosis of asymptomatic varicoceles. Varicoceles have recently been implicated as a possible reversible contributor to hypogonadism. Hypogonadism may be associated with significant adverse effect, including decreased libido, impaired cognitive function, and increased cardiovascular events. Early diagnosis and treatment of hypogonadism may prevent these adverse sequelae. Data were collected from the Truven Health Analytics MarketScan database, a large outpatient claims database. We reviewed records between 2003 and 2010 for male patients between the ages of 25 and 50 years with International Classification of Diseases, Ninth Revision codes for hypogonadism, vasectomy, and varicocele, and queried dates of first claim. A total of 15,679 men undergoing vasectomies were matched with 156,790 men with nonvasectomy claims in the same year. Vasectomy patients were diagnosed with varicocele at an earlier age (40.9 vs 42.5 years; P=.009). We identified 224,817 men between the ages of 25 and 50 years with a claim of hypogonadism, of which 5883 (2.6%) also had a claim of varicocele. Men with hypogonadism alone were older at presentation compared with men with an accompanying varicocele (41.3 [standard deviation±6.5] vs 34.9 [standard deviation±6.1]; P<.001). Men undergoing vasectomies are diagnosed with varicoceles at a younger age than age-matched controls. Men with varicoceles present with hypogonadism earlier than men without varicoceles. Earlier diagnosis of varicocele at the time of vasectomy allows for earlier detection of hypogonadism. Copyright © 2014 Elsevier Inc. All rights reserved.

Spatial variability and trends of seasonal snowmelt processes over Antarctic sea ice observed by satellite scatterometers

NASA Astrophysics Data System (ADS)

Arndt, S.; Haas, C.

2017-12-01

Snow is one of the key drivers determining the seasonal energy and mass budgets of sea ice in the Southern Ocean. Here, we analyze radar backscatter time series from the European Remote Sensing Satellites (ERS)-1 and-2 scatterometers, from the Quick Scatterometer (QSCAT), and from the Advanced Scatterometer (ASCAT) in order to observe the regional and inter-annual variability of Antarctic snowmelt processes from 1992 to 2014. On perennial ice, seasonal backscatter changes show two different snowmelt stages: A weak backscatter rise indicating the initial warming and metamorphosis of the snowpack (pre-melt), followed by a rapid rise indicating the onset of internal snowmelt and thaw-freeze cycles (snowmelt). In contrast, similar seasonal backscatter cycles are absent on seasonal ice, preventing the periodic retrieval of spring/summer transitions. This may be due to the dominance of ice bottom melt over snowmelt, leading to flooding and ice disintegration before strong snowmelt sets in. Resulting snowmelt onset dates on perennial sea ice show the expected latitudinal gradient from early melt onsets (mid-November) in the northern Weddell Sea towards late (end-December) or even absent snowmelt conditions further south. This result is likely related to seasonal variations in solar shortwave radiation (absorption). In addition, observations with different microwave frequencies allow to detect changing snow properties at different depths. We show that short wavelengths of passive microwave observations indicate earlier pre-melt and snowmelt onset dates than longer wavelength scatterometer observations, in response to earlier warming of upper snow layers compared to lower snow layers. Similarly, pre-melt and snowmelt onset dates retrieved from Ku-Band radars were earlier by an average of 11 and 23 days, respectively, than those retrieved from C-Band. This time difference was used to correct melt onset dates retrieved from Ku-Band to compile a consistent time series from

Mars Observer Lecture: Mars Orbit Insertion

NASA Technical Reports Server (NTRS)

Dodd, Suzanne R. (Personal Name)

1993-01-01

The Mars Observer mission spacecraft was primarily designed for exploring Mars and the Martian environment. The Mars Observer was launched on September 25, 1992. The spacecraft was lost in the vicinity of Mars on August 21, 1993 when the spacecraft began its maneuvering sequence for Martian orbital insertion. This videotape shows a lecture by Suzanne R. Dodd, the Mission Planning Team Chief for the Mars Observer Project. Ms Dodd begins with a brief overview of the mission and the timeline from the launch to orbital insertion. Ms Dodd then reviews slides showing the trajectory of the spacecraft on its trip to Mars. Slides of the spacecraft being constructed are also shown. She then discusses the Mars orbit insertion and the events that will occur to move the spacecraft from the capture orbit into a mapping orbit. During the trip to Mars, scientists at JPL had devised a new strategy, called Power In that would allow for an earlier insertion into the mapping orbit. The talk summarizes this strategy, showing on a slide the planned transition orbits. There are shots of the Martian moon, Phobos, taken from the Viking spacecraft, as Ms Dodd explains that the trajectory will allow the orbiter to make new observations of that moon. She also explains the required steps to prepare for mapping after the spacecraft has achieved the mapping orbit around Mars. The lecture ends with a picture of Mars from the Observer on its approach to the planet.

Decreased length of stay and earlier oral feeding associated with standardized postoperative clinical care for total gastrectomies at a cancer center.

PubMed

Selby, Luke V; Rifkin, Marissa B; Yoon, Sam S; Ariyan, Charlotte E; Strong, Vivian E

2016-09-01

Standardization of postoperative care has been shown to decrease postoperative length of stay. In June 2009, we standardized postoperative care for all gastrectomies at our institution. Four years' worth of total gastrectomies (2 years prior to standardization and 2 years after standardization) were reviewed to determine the effect of standardization on postoperative care, length of stay, complications, and readmissions. Between June 2007 and July 2011, 99 patients underwent curative intent open total gastrectomy: 51 patients prior to standardization, and 48 patients poststandardization. Patients were predominantly male (70%); median age was 63; and median body mass index was 26. Standardization of postoperative care was associated with a decrease in median time to beginning both clear liquids and a postgastrectomy diet, earlier removal of epidural catheters, earlier use of oral pain medication, less time receiving intravenous fluids, and decreased length of stay (all P < .01). Groups showed no differences in complication rates, complication severity, diet intolerance, return to our Urgent Care Center, or readmission. Institution of standardized postoperative orders for total gastrectomy was associated with a significantly decreased length of stay and earlier oral feeding without increasing postoperative complications, early postoperative outpatient visits, or readmissions. Copyright © 2016 Elsevier Inc. All rights reserved.

Earlier occurrence and increased explanatory power of climate for the first incidence of potato late blight caused by Phytophthora infestans in Fennoscandia

PubMed Central

Wiik, Lars; Hannukkala, Asko; Andreasson, Erik; Chen, Deliang; Ou, Tinghai; Liljeroth, Erland; Lankinen, Åsa

2017-01-01

Background Late blight (caused by Phytophthora infestans) is a devastating potato disease that has been found to occur earlier in the season over the last decades in Fennoscandia. Up until now the reasons for this change have not been investigated. Possible explanations for this change are climate alterations, changes in potato production or changes in pathogen biology, such as increased fitness or changes in gene flow within P. infestans populations. The first incidence of late blight is of high economic importance since fungicidal applications should be typically applied two weeks before the first signs of late blight and are repeated on average once a week. Methods We use field observations of first incidence of late blight in experimental potato fields from five sites in Sweden and Finland covering a total of 30 years and investigate whether the earlier incidence of late blight can be related to the climate. Results We linked the field data to meteorological data and found that the previous assumption, used in common late blight models, that the disease only develops at relative humidity levels above 90% had to be rejected. Rather than the typically assumed threshold relationship between late blight disease development and relative humidity we found a linear relationship. Our model furthermore showed two distinct responses of late blight to climate. At the beginning of the observation time (in Sweden until the early 90s and in Finland until the 2000s) the link between climate and first incidence was very weak. However, for the remainder of the time period the link was highly significant, indicating a change in the biological properties of the pathogen which could for example be a change in the dominating reproduction mode or a physiological change in the response of the pathogen to climate. Conclusions The study shows that models used in decision support systems need to be checked and re-parametrized regularly to be able to capture changes in pathogen biology

Earlier Right Ventricular Pacing in Cardiac Resynchronization Therapy for a Patient with Right Axis Deviation.

PubMed

Hattori, Yusuke; Ishibashi, Kohei; Noda, Takashi; Okamura, Hideo; Kanzaki, Hideaki; Anzai, Toshihisa; Yasuda, Satoshi; Kusano, Kengo

2017-09-01

We describe the case of a 37-year-old woman who presented with complete right bundle branch block and right axis deviation. She was admitted to our hospital due to severe heart failure and was dependent on inotropic agents. Cardiac resynchronization therapy was initiated but did not improve her condition. After the optimization of the pacing timing, we performed earlier right ventricular pacing, which led to an improvement of her heart failure. Earlier right ventricular pacing should be considered in patients with complete right bundle branch block and right axis deviation when cardiac resynchronization therapy is not effective.

A reversal of the shift towards earlier spring phenology in several Mediterranean reptiles and amphibians during the 1998-2013 warming slowdown.

PubMed

Prodon, Roger; Geniez, Philippe; Cheylan, Marc; Devers, Florence; Chuine, Isabelle; Besnard, Aurelien

2017-12-01

Herps, especially amphibians, are particularly susceptible to climate change, as temperature tightly controls many parameters of their biological cycle-above all, their phenology. The timing of herps' activity or migration period-in particular the dates of their first appearance in spring and first breeding-and the shift to earlier dates in response to warming since the last quarter of the 20 th century has often been described up to now as a nearly monotonic trend towards earlier phenological events. In this study, we used citizen science data opportunistically collected on reptiles and amphibians in the northern Mediterranean basin over a period of 32 years to explore temporal variations in herp phenology. For 17 common species, we measured shifts in the date of the species' first spring appearance-which may be the result of current changes in climate-and regressed the first appearance date against temperatures and precipitations. Our results confirmed the expected overall trend towards earlier first spring appearances from 1983 to 1997, and show that the first appearance date of both reptiles and amphibians fits well with the temperature in late winter. However, the trend towards earlier dates was stopped or even reversed in most species between 1998 and 2013. We interpret this reversal as a response to cooling related to the North Atlantic Oscillation (NAO) in the late winter and early spring. During the positive NAO episodes, for certain species only (mainly amphibians), the effect of a warm weather, which tends to advance the phenology, seems to be counterbalanced by the adverse effects of the relative dryness. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.

Earlier anal sexarche and co-occurring sexual risk are associated with current HIV-related risk behaviors among an online sample of men who have sex with men in Asia

PubMed Central

Cheung, Doug H.; Suharlim, Christian; Guadamuz, Thomas E.; Lim, Sin How; Koe, Stuart; Wei, Chongyi

2014-01-01

Studies of heterosexual populations across the globe and men who have sex with men (MSM) in a few developed countries showed that earlier sexual debut (sexarche) was associated with higher levels of co-occurring and subsequent HIV risk behaviors. We examined the relationships between earlier anal sexarche, unprotected earlier anal sexarche and current HIV risks among MSM from Asia. A cross-sectional online survey was conducted among MSM (N = 10,826) in Asia in 2010. Bivariate and multivariable logistic regressions were used to identify co-occurring (i.e., sexual experiences during sexarche) and current HIV-related risk factors (i.e., past six months) associated with earlier anal sexarche (before the age of 18) and unprotected earlier anal sexarche, respectively. Earlier anal sexarche was significantly associated with lack of condom use, being anal receptive or both receptive and insertive, and having a partner who were older during sexarche. It was also associated with current HIV-related risk behaviors including having multiple male sexual partners, having been paid for sex, and increased frequencies of recreational drug use. Unprotected earlier anal sexarche was significantly associated with inconsistent condom use in the past the six months. Improved and culturally sensitive sex education at schools should be included in national and regional HIV/AIDS prevention programming and policies in Asia. Such sex education programs should incorporate curriculum that address sexuality, sexual orientation, and sexual behaviors beyond those related to reproductive health. PMID:24920344

Earlier anal sexarche and co-occurring sexual risk are associated with current HIV-related risk behaviors among an online sample of men who have sex with men in Asia.

PubMed

Cheung, Doug H; Suharlim, Christian; Guadamuz, Thomas E; Lim, Sin How; Koe, Stuart; Wei, Chongyi

2014-12-01

Studies of heterosexual populations across the globe and men who have sex with men (MSM) in a few developed countries showed that earlier sexual debut (sexarche) was associated with higher levels of co-occurring and subsequent HIV risk behaviors. We examined the relationships between earlier anal sexarche, unprotected earlier anal sexarche and current HIV risks among MSM from Asia. A cross-sectional online survey was conducted among MSM (N = 10,826) in Asia in 2010. Bivariate and multivariable logistic regressions were used to identify co-occurring (i.e., sexual experiences during sexarche) and current HIV-related risk factors (i.e., past 6 months) associated with earlier anal sexarche (before the age of 18) and unprotected earlier anal sexarche, respectively. Earlier anal sexarche was significantly associated with lack of condom use, being anal receptive or both receptive and insertive, and having a partner who were older during sexarche. It was also associated with current HIV-related risk behaviors including having multiple male sexual partners, having been paid for sex, and increased frequencies of recreational drug use. Unprotected earlier anal sexarche was significantly associated with inconsistent condom use in the past the 6 months. Improved and culturally sensitive sex education at schools should be included in national and regional HIV/AIDS prevention programming and policies in Asia. Such sex education programs should incorporate curriculum that address sexuality, sexual orientation, and sexual behaviors beyond those related to reproductive health.

Gun shows across a multistate American gun market: observational evidence of the effects of regulatory policies.

PubMed

Wintemute, Garen J

2007-06-01

To describe gun shows and assess the impact of increased regulation on characteristics linked to their importance as sources of guns used in crime. Cross-sectional, observational. Data were collected at a structured sample of 28 gun shows in California, which regulates these events and prohibits undocumented private party gun sales; and in Arizona, Nevada, Texas and Florida-all leading sources of California's crime guns--where these restrictions do not exist. Size of shows, measured by numbers of gun vendors and people in attendance; number and nature of guns for sale by gun vendors; measures of private party gun sales and illegal surrogate ("straw") gun purchases. Shows in comparison states were larger, but the number of attendees per gun vendor was higher in California. None of these differences was statistically significant. Armed attendees were more common in other states (median 5.7%, interquartile range (IQR) 3.9-10.0%) than in California (median 1.1%, IQR 0.5-2.2%), p = 0.0007. Thirty percent of gun vendors both in California and elsewhere were identifiable as licensed firearm retailers. There were few differences in the types or numbers of guns offered for sale; vendors elsewhere were more likely to sell assault weapons (34.9% and 13.3%, respectively; p = 0.001). Straw purchases were more common in the comparison states (rate ratio 6.6 (95% CI 0.9 to 49.1), p = 0.06). California's regulatory policies were associated with a decreased incidence of anonymous, undocumented gun sales and illegal straw purchases at gun shows. No significant adverse effects of these policies were observed.

Accessing Real-Life Episodic Information from Minutes versus Hours Earlier Modulates Hippocampal and High-Order Cortical Dynamics

PubMed Central

Chen, J.; Honey, C. J.; Simony, E.; Arcaro, M. J.; Norman, K. A.; Hasson, U.

2016-01-01

It is well known that formation of new episodic memories depends on hippocampus, but in real-life settings (e.g., conversation), hippocampal amnesics can utilize information from several minutes earlier. What neural systems outside hippocampus might support this minutes-long retention? In this study, subjects viewed an audiovisual movie continuously for 25 min; another group viewed the movie in 2 parts separated by a 1-day delay. Understanding Part 2 depended on retrieving information from Part 1, and thus hippocampus was required in the day-delay condition. But is hippocampus equally recruited to access the same information from minutes earlier? We show that accessing memories from a few minutes prior elicited less interaction between hippocampus and default mode network (DMN) cortical regions than accessing day-old memories of identical events, suggesting that recent information was available with less reliance on hippocampal retrieval. Moreover, the 2 groups evinced reliable but distinct DMN activity timecourses, reflecting differences in information carried in these regions when Part 1 was recent versus distant. The timecourses converged after 4 min, suggesting a time frame over which the continuous-viewing group may have relied less on hippocampal retrieval. We propose that cortical default mode regions can intrinsically retain real-life episodic information for several minutes. PMID:26240179

Presetting ECG electrodes for earlier heart rate detection in the delivery room.

PubMed

Gulati, Rashmi; Zayek, Michael; Eyal, Fabien

2018-07-01

To determine whether heart rate (HR) could be detected earlier than by pulse oximeter (POX), using a novel method of application of electrocardiogram (ECG) electrodes during neonatal resuscitation in the delivery room. ECG electrodes were set before delivery to be applied to the back of infants' thorax. Time to detect HR was recorded as soon as a numerical HR along with a recognizable and persistent QRS complex was observed on ECG monitor (HRECG) and a plethysmographic waveform was seen on POX monitor (HRPOX). Out of 334 infants, 49 were <31 weeks of gestational age. Overall, the median (interquartile range, IQR) time to detect HRECG was significantly shorter [29 (5, 60) seconds] than time by POX [60 (45,120) seconds], (p < 0.001). Similarly, in <31-week infants, the median (IQR) time to detect HRECG was 10 (2, 40) seconds compared to 60 (30,120) seconds by POX, (p < 0.001). Failure to have HR detected by 1 minute occurred in 30%, 54% and 20% of infants by ECG, POX and either of the devices, respectively. In the delivery room, electrodes applied by the study method are more effective than pulse oximetry in providing the neonatal team with timely HR information that is necessary for proper resuscitative actions. Published by Elsevier B.V.

Earlier versus later continuous Kangaroo Mother Care (KMC) for stable low-birth-weight infants: a randomized controlled trial.

PubMed

Nagai, S; Andrianarimanana, D; Rabesandratana, N; Yonemoto, N; Nakayama, T; Mori, R

2010-06-01

The aim of this study was to examine the effectiveness of earlier continuous Kangaroo Mother Care (KMC) for relatively stable low-birth-weight (LBW) infants in a resource-limited country. A randomized controlled trial was performed in LBW infants at a referral hospital in Madagascar. Earlier continuous KMC (intervention) was begun as soon as possible, within 24 h postbirth, and later continuous KMC (control: conventional care) was begun after complete stabilization (generally after 24 h postbirth). Main outcome measure was mortality during the first 28 days postbirth. This trial was registered with ClinicalTrials.gov, NCT00531492. A total of 73 infants (intervention 37, control 36) were included. Earlier continuous KMC had higher but no statistically different mortality in the first 28 days postbirth (1 vs. 2; risk ratio, 1.95; 95% CIs, 0.18-20.53; p = 1.00). There were no differences in incidence of morbidities. Body weight loss from birth to 24 h postbirth was significantly less in earlier KMC infants compared with later KMC infants. (-34.81 g vs. -73.97 g; mean difference, 39.16 g; 95% CIs, 10.30-68.03; p = 0.01; adjusted p = 0.02). Adverse events and duration of hospitalization were not different between the two groups. Further evaluations of earlier continuous KMC including measurement of KMC dose, are needed in resource-limited countries.

Missed opportunities for earlier diagnosis of HIV in patients who presented with advanced HIV disease: a retrospective cohort study

PubMed Central

Levy, Itzchak; Maor, Yasmin; Mahroum, Naim; Olmer, Liraz; Wieder, Anat; Litchevski, Vladislav; Mor, Orna; Rahav, Galia

2016-01-01

Objective To quantify and characterise missed opportunities for earlier HIV diagnosis in patients diagnosed with advanced HIV. Design A retrospective observational cohort study. Setting A central tertiary medical centre in Israel. Measures The proportion of patients with advanced HIV, the proportion of missed opportunities to diagnose them earlier, and the rate of clinical indicator diseases (CIDs) in those patients. Results Between 2010 and 2015, 356 patients were diagnosed with HIV, 118 (33.4%) were diagnosed late, 57 (16%) with advanced HIV disease. Old age (OR=1.45 (95% CI 1.16 to 1.74)) and being heterosexual (OR=2.65 (95% CI 1.21 to 5.78)) were significant risk factors for being diagnosed late. All patients with advanced disease had at least one CID that did not lead to an HIV test in the 5 years prior to AIDS diagnosis. The median time between CID and AIDS diagnosis was 24 months (IQR 10–30). 60% of CIDs were missed by a general practitioner and 40% by a specialist. Conclusions Missed opportunities to early diagnosis of HIV occur in primary and secondary care. Lack of national guidelines, lack of knowledge regarding CIDs and communication barriers with patients may contribute to a late diagnosis of HIV. PMID:28186940

Gun shows across a multistate American gun market: observational evidence of the effects of regulatory policies

PubMed Central

Wintemute, Garen J

2007-01-01

Objective To describe gun shows and assess the impact of increased regulation on characteristics linked to their importance as sources of guns used in crime. Design Cross‐sectional, observational. Subjects Data were collected at a structured sample of 28 gun shows in California, which regulates these events and prohibits undocumented private party gun sales; and in Arizona, Nevada, Texas and Florida—all leading sources of California's crime guns—where these restrictions do not exist. Main outcome measures Size of shows, measured by numbers of gun vendors and people in attendance; number and nature of guns for sale by gun vendors; measures of private party gun sales and illegal surrogate (“straw”) gun purchases. Results Shows in comparison states were larger, but the number of attendees per gun vendor was higher in California. None of these differences was statistically significant. Armed attendees were more common in other states (median 5.7%, interquartile range (IQR) 3.9–10.0%) than in California (median 1.1%, IQR 0.5–2.2%), p = 0.0007. Thirty percent of gun vendors both in California and elsewhere were identifiable as licensed firearm retailers. There were few differences in the types or numbers of guns offered for sale; vendors elsewhere were more likely to sell assault weapons (34.9% and 13.3%, respectively; p = 0.001). Straw purchases were more common in the comparison states (rate ratio 6.6 (95% CI 0.9 to 49.1), p = 0.06). Conclusions California's regulatory policies were associated with a decreased incidence of anonymous, undocumented gun sales and illegal straw purchases at gun shows. No significant adverse effects of these policies were observed. PMID:17567968

A Review of Quality of Life after Predictive Testing for and Earlier Identification of Neurodegenerative Diseases

PubMed Central

Paulsen, Jane S.; Nance, Martha; Kim, Ji-In; Carlozzi, Noelle E.; Panegyres, Peter K.; Erwin, Cheryl; Goh, Anita; McCusker, Elizabeth; Williams, Janet K.

2013-01-01

The past decade has witnessed an explosion of evidence suggesting that many neurodegenerative diseases can be detected years, if not decades, earlier than previously thought. To date, these scientific advances have not provoked any parallel translational or clinical improvements. There is an urgency to capitalize on this momentum so earlier detection of disease can be more readily translated into improved health-related quality of life for families at risk for, or suffering with, neurodegenerative diseases. In this review, we discuss health-related quality of life (HRQOL) measurement in neurodegenerative diseases and the importance of these “patient reported outcomes” for all clinical research. Next, we address HRQOL following early identification or predictive genetic testing in some neurodegenerative diseases: Huntington disease, Alzheimer's disease, Parkinson's disease, Dementia with Lewy bodies, frontotemporal dementia, amyotrophic lateral sclerosis, prion diseases, hereditary ataxias, Dentatorubral-pallidoluysian atrophy and Wilson's disease. After a brief report of available direct-to-consumer genetic tests, we address the juxtaposition of earlier disease identification with assumed reluctance towards predictive genetic testing. Forty-one studies examining health related outcomes following predictive genetic testing for neurodegenerative disease suggested that (a) extreme or catastrophic outcomes are rare; (b) consequences commonly include transiently increased anxiety and/or depression; (c) most participants report no regret; (d) many persons report extensive benefits to receiving genetic information; and (e) stigmatization and discrimination for genetic diseases are poorly understood and policy and laws are needed. Caution is appropriate for earlier identification of neurodegenerative diseases but findings suggest further progress is safe, feasible and likely to advance clinical care. PMID:24036231

CASSINI VIMS OBSERVATIONS SHOW ETHANE IS PRESENT IN TITAN'S RAINFALL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dalba, Paul A.; Buratti, Bonnie J.; Baines, Kevin H.

2012-12-20

Observations obtained over two years by the Cassini Imaging Science Subsystem suggest that rain showers fall on the surface. Using measurements obtained by the Visual Infrared Mapping Spectrometer, we identify the main component of the rain to be ethane, with methane as an additional component. We observe five or six probable rainfall events, at least one of which follows a brief equatorial cloud appearance, suggesting that frequent rainstorms occur on Titan. The rainfall evaporates, sublimates, or infiltrates on timescales of months, and in some cases it is associated with fluvial features but not with their creation or alteration. Thus, Titanmore » exhibits frequent 'gentle rainfall' instead of, or in addition to, more catastrophic events that cut rivers and lay down large fluvial deposits. Freezing rain may also be present, and the standing liquid may exist as puddles interspersed with patches of frost. The extensive dune deposits found in the equatorial regions of Titan imply multi-season arid conditions there, which are consistent with small, but possibly frequent, amounts of rain, in analogy to terrestrial deserts.« less

Developing A Model for Lake Ice Phenology Using Satellite Remote Sensing Observations

NASA Astrophysics Data System (ADS)

Skoglund, S. K.; Weathers, K. C.; Norouzi, H.; Prakash, S.; Ewing, H. A.

2017-12-01

Many northern temperate freshwater lakes are freezing over later and thawing earlier. This shift in timing, and the resulting shorter duration of seasonal ice cover, is expected to impact ecological processes, negatively affecting aquatic species and the quality of water we drink. Long-term, direct observations have been used to analyze changes in ice phenology, but those data are sparse relative to the number of lakes affected. Here we develop a model to utilize remote sensing data in approximating the dates of ice-on and ice-off for many years over a variety of lakes. Day and night surface temperatures from MODIS (Moderate Resolution Imaging Spectroradiometer) Aqua and Terra (MYD11A1 and MOD11A1 data products) for 2002-2017 were utilized in combination with observed ice-on and ice-off dates of Lake Auburn, Maine, to determine the ability of MODIS data to match ground-based observations. A moving average served to interpolate MODIS temperature data to fill data gaps from cloudy days. The nighttime data were used for ice-off, and the daytime measurements were used for ice-on predictions to avoid fluctuations between day and night ice/water status. The 0˚C intercepts of those data were used to mark approximate days of ice-on or ice-off. This revealed that approximations for ice-off dates were satisfactory (average ±8.2 days) for Lake Auburn as well as for Lake Sunapee, New Hampshire (average ±8.1 days), while approximations for Lake Auburn ice-on were less accurate and showed consistently earlier-than-observed ice-on dates (average -33.8 days). The comparison of observed and remotely sensed Lake Auburn ice cover duration showed relative agreement with a correlation coefficient of 0.46. Other remote sensing observations, such as the new GOES-R satellite, and further exploration of the ice formation process can improve ice-on approximation methods. The model shows promise for estimating ice-on, ice-off, and ice cover duration for northern temperate lakes.

Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease.

PubMed

Schaffert, Jeff; LoBue, Christian; White, Charles L; Chiang, Hsueh-Sheng; Didehbani, Nyaz; Lacritz, Laura; Rossetti, Heidi; Dieppa, Marisara; Hart, John; Cullum, C Munro

2018-05-01

To evaluate whether a history of traumatic brain injury (TBI) with reported loss of consciousness (LOC) is a risk factor for earlier onset of Alzheimer's disease (AD) in an autopsy-confirmed sample. Data from 2,133 participants with autopsy-confirmed AD (i.e., at least Braak neurofibrillary tangle stages III to VI and CERAD neuritic plaque score moderate to frequent) were obtained from the National Alzheimer's Coordinating Center (NACC). Participants were categorized by presence/absence of self-reported remote (i.e., >1 year prior to their first Alzheimer's Disease Center visit) history of TBI with LOC (TBI+ vs. TBI-). Analyses of Covariance (ANCOVA) controlling for sex, education, and race compared groups on clinician-estimated age of symptom onset and age of diagnosis. Average age of onset was 2.34 years earlier (p = .01) for the TBI+ group (n = 194) versus the TBI- group (n = 1900). Dementia was diagnosed on average 2.83 years earlier (p = .002) in the TBI+ group (n = 197) versus the TBI- group (n = 1936). Using more stringent neuropathological criteria (i.e., Braak stages V-VI and CERAD frequent), both age of AD onset and diagnosis were 3.6 years earlier in the TBI+ group (both p's < .001). History of TBI with reported LOC appears to be a risk factor for earlier AD onset. This is the first study to use autopsy-confirmed cases, supporting previous investigations that used clinical criteria for the diagnosis of AD. Further investigation as to possible underlying mechanisms of association is needed. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Earlier Parental Set Bedtimes as a Protective Factor Against Depression and Suicidal Ideation

PubMed Central

Gangwisch, James E.; Babiss, Lindsay A.; Malaspina, Dolores; Turner, J. Blake; Zammit, Gary K.; Posner, Kelly

2010-01-01

Study Objectives: To examine the relationships between parental set bedtimes, sleep duration, and depression as a quasi-experiment to explore the potentially bidirectional relationship between short sleep duration and depression. Short sleep duration has been shown to precede depression, but this could be explained as a prodromal symptom of depression. Depression in an adolescent can affect his/her chosen bedtime, but it is less likely to affect a parent's chosen set bedtime which can establish a relatively stable upper limit that can directly affect sleep duration. Design: Multivariate cross-sectional analyses of the ADD Health using logistic regression. Setting: United States nationally representative, school-based, probability-based sample in 1994-96. Participants: Adolescents (n = 15,659) in grades 7 to 12. Measurements and Results: Adolescents with parental set bedtimes of midnight or later were 24% more likely to suffer from depression (OR = 1.24, 95% CI 1.04-1.49) and 20% more likely to have suicidal ideation (1.20, 1.01-1.41) than adolescents with parental set bedtimes of 10:00 PM or earlier, after controlling for covariates. Consistent with sleep duration and perception of getting enough sleep acting as mediators, the inclusion of these variables in the multivariate models appreciably attenuated the associations for depression (1.07, 0.88-1.30) and suicidal ideation (1.09, 0.92-1.29). Conclusions: The results from this study provide new evidence to strengthen the argument that short sleep duration could play a role in the etiology of depression. Earlier parental set bedtimes could therefore be protective against adolescent depression and suicidal ideation by lengthening sleep duration. Citation: Gangwisch JE; Babiss LA; Malaspina D; Turner JB; Zammit GK; Posner K. Earlier parental set bedtimes as a protective factor against depression and suicidal ideation. SLEEP 2010;33(1):97-106. PMID:20120626

40 CFR 87.21 - Exhaust emission standards for Tier 4 and earlier engines.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Emissions (New Aircraft Gas Turbine Engines) § 87.21 Exhaust emission standards for Tier 4 and earlier... standards. (a) Exhaust emissions of smoke from each new aircraft gas turbine engine of class T8 manufactured... from each new aircraft gas turbine engine of class TF and of rated output of 129 kilonewtons thrust or...

40 CFR 87.21 - Exhaust emission standards for Tier 4 and earlier engines.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Emissions (New Aircraft Gas Turbine Engines) § 87.21 Exhaust emission standards for Tier 4 and earlier... standards. (a) Exhaust emissions of smoke from each new aircraft gas turbine engine of class T8 manufactured... from each new aircraft gas turbine engine of class TF and of rated output of 129 kilonewtons thrust or...

Earlier predictors of eating disorder symptoms in 9-year-old children. A longitudinal study.

PubMed

Parkinson, Kathryn N; Drewett, Robert F; Le Couteur, Ann S; Adamson, Ashley J

2012-08-01

The aim of the study was to examine predictors of eating disorder symptoms in a population based sample at the earliest age at which they can be measured using the Children's Eating Attitudes Test. Data were collected from the longitudinal Gateshead Millennium Study cohort; 609 children participated in the 7 year data sweep (and their mothers and teachers), and 589 children participated in the 9 year data sweep. Eating disorder symptoms at 9 years were higher in boys, and in children from more deprived families. Higher eating disorder symptoms were associated with more body dissatisfaction at 9 years. Higher symptoms were predicted by higher levels of dietary restraint and of emotional symptoms, but not greater body dissatisfaction, 2 years earlier. The study showed that some correlates of high eating disorder symptoms found in adolescents and adults are also found in children, before the rise in diagnosable eating disorders over the pubertal period. Copyright © 2012 Elsevier Ltd. All rights reserved.

Moderately premature infants at Kaiser Permanente Medical Care Program in California are discharged home earlier than their peers in Massachusetts and the United Kingdom

PubMed Central

Profit, J; Zupancic, J A F; McCormick, M C; Richardson, D K; Escobar, G J; Tucker, J; Tarnow‐Mordi, W; Parry, G

2006-01-01

Objective To compare gestational age at discharge between infants born at 30–34+6 weeks gestational age who were admitted to neonatal intensive care units (NICUs) in California, Massachusetts, and the United Kingdom. Design Prospective observational cohort study. Setting Fifty four United Kingdom, five California, and five Massachusetts NICUs. Subjects A total of 4359 infants who survived to discharge home after admission to an NICU. Main outcome measures Gestational age at discharge home. Results The mean (SD) postmenstrual age at discharge of the infants in California, Massachusetts, and the United Kingdom were 35.9 (1.3), 36.3 (1.3), and 36.3 (1.9) weeks respectively (p  =  0.001). Compared with the United Kingdom, adjusted discharge of infants occurred 3.9 (95% confidence interval (CI) 1.4 to 6.5) days earlier in California, and 0.9 (95% CI −1.2 to 3.0) days earlier in Massachusetts. Conclusions Infants of 30–34+6 weeks gestation at birth admitted and cared for in hospitals in California have a shorter length of stay than those in the United Kingdom. Certain characteristics of the integrated healthcare approach pursued by the health maintenance organisation of the NICUs in California may foster earlier discharge. The California system may provide opportunities for identifying practices for reducing the length of stay of moderately premature infants. PMID:16449257

Reducing Older Driver Motor Vehicle Collisions via Earlier Cataract Surgery

PubMed Central

Mennemeyer, Stephen T.; Owsley, Cynthia; McGwin, Gerald

2013-01-01

Older adults who undergo cataract extraction have roughly half the rate of motor vehicle collision (MVC) involvement per mile driven compared to cataract patients who do not elect cataract surgery. Currently in the U.S., most insurers do not allow payment for cataract surgery based upon the findings of a vision exam unless accompanied by an individual’s complaint of visual difficulties that seriously interfere with driving or other daily activities and individuals themselves may be slow or reluctant to complain and seek relief. As a consequence, surgery tends to occur after significant vision problems have emerged. We hypothesize that a proactive policy encouraging cataract surgery earlier for a lesser level of complaint would significantly reduce MVCs among older drivers. We used a Monte Carlo model to simulate the MVC experience of the U.S. population from age 60 to 89 under alternative protocols for the timing of cataract surgery which we call “Current Practice” (CP) and “Earlier Surgery” (ES). Our base model finds, from a societal perspective with undiscounted 2010 dollars, that switching to ES from CP reduces by about 21% the average number of MVCs, fatalities, and MVC cost per person. The net effect on total cost – all MVC costs plus cataract surgery expenditures -- is a reduction of about 16%. Quality Adjusted Life Years would increase by about 5%. From the perspective of payers for healthcare, the switch would increase cataract surgery expenditure for ages 65+ by about 8% and for ages 60 to 64 by about 47% but these expenditures are substantially offset after age 65 by reductions in the medical and emergency services component of MVC cost. Similar results occur with discounting at 3% and with various sensitivity analyses. We conclude that a policy of ES would significantly reduce MVCs and their associated consequences. PMID:23369786

Carbon cycle observations: gaps threaten climate mitigation policies

Treesearch

Richard Birdsey; Nick Bates; MIke Behrenfeld; Kenneth Davis; Scott C. Doney; Richard Feely; Dennis Hansell; Linda Heath; et al.

2009-01-01

Successful management of carbon dioxide (CO2) requires robust and sustained carbon cycle observations. Yet key elements of a national observation network are lacking or at risk. A U.S. National Research Council review of the U.S. Climate Change Science Program earlier this year highlighted the critical need for a U.S. climate observing system to...

Earlier Endpoints Are Required for Hemorrhagic Shock Trials among Severely Injured Patients

PubMed Central

Fox, Erin E.; Holcomb, John B.; Wade, Charles E.; Bulger, Eileen M.; Tilley, Barbara C.

2016-01-01

Background Choosing the appropriate endpoint for a trauma hemorrhage control trial can determine the likelihood of its success. Recent Phase 3 trials and observational studies have used 24-hour and/or 30-day all-cause mortality as the primary endpoint and some have not used exception from informed consent (EFIC), resulting in multiple failed trials. Five recent high-quality prospective studies among 4,064 hemorrhaging trauma patients provide new evidence to support earlier primary endpoints. Methods The goal of this project was to determine the optimal endpoint for hemorrhage control trials using existing literature and new analyses of previously published data. Results Recent studies among bleeding trauma patients show that hemorrhagic deaths occur rapidly, at a high rate, and in a consistent pattern. Early preventable deaths among trauma patients are largely due to hemorrhage and the median time to hemorrhagic death from admission is 2.0-2.6 hours. Approximately 85% of hemorrhagic deaths occur within 6 hours. The hourly mortality rate due to traumatic injury decreases rapidly after enrollment from 4.6% per hour at 1 hour post-enrollment to 1% per hour at 6 hours to <0.1% per hour by 9 hours and thereafter. Early primary endpoints (within 6 hours) have critically important benefits for hemorrhage control trials, including being congruent with the median time to hemorrhagic death, biologic plausibility, and enabling the use of all-cause mortality, which is definitive and objective. Conclusions Primary endpoints should be congruent with the timing of the disease process. Therefore, if a resuscitation/hemorrhage control intervention is under study, a primary endpoint of all-cause mortality evaluated within the first 6 hours is appropriate. Before choosing the timing of the primary endpoint for a large multicenter trial, we recommend performing a Phase 2 trial under EFIC to better understand the effects of the hemorrhage control intervention and distribution of time

Daily Use, Especially of High-Potency Cannabis, Drives the Earlier Onset of Psychosis in Cannabis Users

PubMed Central

Di Forti, Marta; Sallis, Hannah; Allegri, Fabio; Trotta, Antonella; Ferraro, Laura; Stilo, Simona A.; Marconi, Arianna; La Cascia, Caterina; Reis Marques, Tiago; Pariante, Carmine; Dazzan, Paola; Mondelli, Valeria; Paparelli, Alessandra; Kolliakou, Anna; Prata, Diana; Gaughran, Fiona; David, Anthony S.; Morgan, Craig; Stahl, Daniel; Khondoker, Mizanur; MacCabe, James H.; Murray, Robin M.

2014-01-01

Cannabis use is associated with an earlier age of onset of psychosis (AOP). However, the reasons for this remain debated. Methods: We applied a Cox proportional hazards model to 410 first-episode psychosis patients to investigate the association between gender, patterns of cannabis use, and AOP. Results: Patients with a history of cannabis use presented with their first episode of psychosis at a younger age (mean years = 28.2, SD = 8.0; median years = 27.1) than those who never used cannabis (mean years = 31.4, SD = 9.9; median years = 30.0; hazard ratio [HR] = 1.42; 95% CI: 1.16–1.74; P < .001). This association remained significant after controlling for gender (HR = 1.39; 95% CI: 1.11–1.68; P < .001). Those who had started cannabis at age 15 or younger had an earlier onset of psychosis (mean years = 27.0, SD = 6.2; median years = 26.9) than those who had started after 15 years (mean years = 29.1, SD = 8.5; median years = 27.8; HR = 1.40; 95% CI: 1.06–1.84; P = .050). Importantly, subjects who had been using high-potency cannabis (skunk-type) every day had the earliest onset (mean years = 25.2, SD = 6.3; median years = 24.6) compared to never users among all the groups tested (HR = 1.99; 95% CI: 1.50- 2.65; P < .0001); these daily users of high-potency cannabis had an onset an average of 6 years earlier than that of non-cannabis users. Conclusions: Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users. PMID:24345517

Long-term effects of earlier initiated continuous Kangaroo Mother Care (KMC) for low-birth-weight (LBW) infants in Madagascar.

PubMed

Nagai, Shuko; Yonemoto, Naohiro; Rabesandratana, Norotiana; Andrianarimanana, Diavolana; Nakayama, Takeo; Mori, Rintaro

2011-12-01

To examine the long-term effects of earlier initiated continuous Kangaroo Mother Care (KMC) for relatively stable low-birth-weight (LBW) infants in a resource-limited country. A randomized controlled trial with long-term follow-up was performed in LBW infants in Madagascar. Earlier continuous KMC (intervention group) was initiated as soon as possible within 24 h postbirth, and later continuous KMC (control group: conventional care) was initiated after complete stabilization. Outcome measures were mortality or readmission, nutritional indicators at 6-12 months postbirth and feeding condition at 6 months postbirth (ClinicalTrials.gov, NCT00531492). A total of 72 infants were followed for mortality or readmission at 6-12 months postbirth. There was no difference between the two groups (7/36 vs. 7/36, Risk ratio (RR), 1.00; 95% CIs, 0.39-2.56; p = 1.00). The proportion of exclusive breast feeding (EBF) at 6 months postbirth was significantly higher with earlier KMC than later KMC (12/29 vs. 4/26; RR 2.69; 95% CIs, 1.00-7.31; p = 0.04). There were no differences in nutritional indicators between the two groups at 6-12 months postbirth. Earlier initiated continuous KMC results in a significantly higher proportion of EBF at 6 months postbirth. Further larger-scale long-term evaluations of earlier initiated continuous KMC for LBW infants are needed. © 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.

Facilitating earlier transfer of care from acute stroke services into the community.

PubMed

Robinson, Jennifer

This article outlines an initiative to reduce length of stay for stroke patients within an acute hospital and to facilitate earlier transfer of care. Existing care provision was remodelled and expanded to deliver stroke care to patients within a community bed-based intermediate care facility or intermediate care at home. This new model of care has improved the delivery of rehabilitation through alternative and innovative ways of addressing service delivery that meet the needs of the patients.

Assessment of Unusual Gigantic Jets observed during the Monsoon season: First observations from Indian Subcontinent.

PubMed

Singh, Rajesh; Maurya, Ajeet K; Chanrion, Olivier; Neubert, Torsten; Cummer, Steven A; Mlynarczyk, Janusz; Cohen, Morris B; Siingh, Devendraa; Kumar, Sushil

2017-11-27

Gigantic Jets are electric discharges from thunderstorm cloud tops to the bottom of ionosphere at ~90 km altitude and electrically connect the troposphere and lower ionosphere. Since their first report in 2002, sporadic observations have been reported from ground and space based observations. Here we report first observations of Gigantic Jets in Indian subcontinent over the Indo-Gangetic plains during the monsoon season. Two storms each produced two jets with characteristics not documented so far. Jets propagated ~37 km up remarkably in ~5 ms with velocity of ~7.4 × 10 6 ms -1 and disappeared within ~40-80 ms, which is faster compared to jets reported earlier. The electromagnetic signatures show that they are of negative polarity, transporting net negative charge of ~17-23 C to the lower ionosphere. One jet had an unusual form observed for the first time, which emerged from the leading edge of a slowly drifting complex convective cloud close to the highest regions at ~17 km altitude. A horizontal displacement of ~10 km developed at ~50 km altitude before connecting to the lower ionosphere. Modeling of these Gigantic jets suggests that Gigantic Jets may bend when initiated at the edge of clouds with misaligned vertical charge distribution.

Fermi-LAT Gamma-ray Observations of Nova Lupus 2016 (ASASSN-16kt)

NASA Astrophysics Data System (ADS)

Cheung, C. C.; Jean, P.; Shore, S. N.; Fermi Large Area Telescope Collaboration

2016-10-01

The Fermi Gamma-ray Space Telescope performed a ~6-day Target of Opportunity (ToO) observation of Nova Lupus 2016 (ATel #9538, #9539, CBET #4322) that commenced on September 28. Considering earlier all-sky survey Large Area Telescope (LAT) observations as well, preliminary analysis indicates gamma-ray emission at ~2 sigma was detected around 1 to 2 days after the optical peak on September 25th (pre-validated AAVSO visual lightcurve; ATel #9550, CBET #4322) when the optical spectra show opaque ejecta, similar to previous gamma-ray detected novae (Fermi-LAT collaboration, 2014 Science 345, 554; Cheung et al. 2016 ApJ 826, 142).

Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users.

PubMed

Di Forti, Marta; Sallis, Hannah; Allegri, Fabio; Trotta, Antonella; Ferraro, Laura; Stilo, Simona A; Marconi, Arianna; La Cascia, Caterina; Reis Marques, Tiago; Pariante, Carmine; Dazzan, Paola; Mondelli, Valeria; Paparelli, Alessandra; Kolliakou, Anna; Prata, Diana; Gaughran, Fiona; David, Anthony S; Morgan, Craig; Stahl, Daniel; Khondoker, Mizanur; MacCabe, James H; Murray, Robin M

2014-11-01

Cannabis use is associated with an earlier age of onset of psychosis (AOP). However, the reasons for this remain debated. We applied a Cox proportional hazards model to 410 first-episode psychosis patients to investigate the association between gender, patterns of cannabis use, and AOP. Patients with a history of cannabis use presented with their first episode of psychosis at a younger age (mean years = 28.2, SD = 8.0; median years = 27.1) than those who never used cannabis (mean years = 31.4, SD = 9.9; median years = 30.0; hazard ratio [HR] = 1.42; 95% CI: 1.16-1.74; P < .001). This association remained significant after controlling for gender (HR = 1.39; 95% CI: 1.11-1.68; P < .001). Those who had started cannabis at age 15 or younger had an earlier onset of psychosis (mean years = 27.0, SD = 6.2; median years = 26.9) than those who had started after 15 years (mean years = 29.1, SD = 8.5; median years = 27.8; HR = 1.40; 95% CI: 1.06-1.84; P = .050). Importantly, subjects who had been using high-potency cannabis (skunk-type) every day had the earliest onset (mean years = 25.2, SD = 6.3; median years = 24.6) compared to never users among all the groups tested (HR = 1.99; 95% CI: 1.50- 2.65; P < .0001); these daily users of high-potency cannabis had an onset an average of 6 years earlier than that of non-cannabis users. Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users. © The Author 2013. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Sensory, physical and chemical characteristics of cooked ham manufactured from rapidly chilled and earlier deboned M. semimembranosus.

PubMed

Tomović, Vladimir M; Jokanović, Marija R; Petrović, Ljiljana S; Tomović, Mila S; Tasić, Tatjana A; Ikonić, Predrag M; Sumić, Zdravko M; Sojić, Branislav V; Skaljac, Snežana B; Sošo, Milena M

2013-01-01

Effects of rapid chilling of carcasses (at -31°C in the first 3h of chilling, and then at 2-4°C) and earlier deboning (8h post-mortem), compared to rapid (till 24h post-mortem) and conventional chilling (at 2-4°C, till 24h post-mortem), on quality characteristics of pork M. semimebranosus and cooked ham were investigated. Quality measurements included pH value, colour (CIEL a b values) and total aerobic count of M. semimebranosus, as well as sensory (colour, juiciness, texture, and flavour), physical (pH value, colour - CIEL a b values and texture - Warner-Bratzler shear and penetration forces) and chemical (protein, total fat, and moisture content) characteristics of cooked ham. The cooked ham was manufactured from pieces of M. semimebranosus with ultimate lightness (CIEL value) lower than 50. Rapid chilling and earlier deboning significantly increased quantity of M. semimebranosus desirable for cooked ham manufacturing. Earlier start of pork fabrication did not affect important quality characteristics of cooked ham. Copyright © 2012 Elsevier Ltd. All rights reserved.

Trends of earlier palliative care consultation in advanced cancer patients receiving palliative radiation therapy.

PubMed

Chang, Sanders; Sigel, Keith; Goldstein, Nathan E; Wisnivesky, Juan; Dharmarajan, Kavita V

2018-06-06

The American Society of Clinical Oncology recommends that all patients with metastatic disease receive dedicated palliative care (PC) services early in their illness, ideally via interdisciplinary care teams. We investigated the time trends of specialty palliative care consultations from the date of metastatic cancer diagnosis among patients receiving palliative radiation therapy (PRT). A shorter time interval between metastatic diagnosis and first PC consultation suggests earlier involvement of palliative care in a patient's life with metastatic cancer. In this IRB-approved retrospective analysis, patients treated with PRT for solid tumors (bone and brain) at a single tertiary care hospital between 2010 and 2016 were included. Cohorts were arbitrarily established by metastatic diagnosis within approximately two-year intervals: (1) 1/1/2010-3/27/2012; (2) 3/28/2012-5/21/2014; and (3) 5/22/2014-12/31/2016. Cox-proportional hazards regression modelling was used to compare trends of PC consultation among cohorts. Of 284 patients identified, 184 patients received PC consultation, whereas 15 patients died before receiving a PC consult. Median follow-up time until an event or censor was 257 days (range: 1,900). Patients in the most recent cohort had a shorter median time to first PC consult (57 days) compared to those in the first (374 days) and second (186 days) cohorts. On multivariable analysis, patients in the third cohort were more likely to undergo a PC consultation earlier in their metastatic illness (HR: 1.8, 95% CI: 1.2,2.8). Over a six-year period, palliative care consultation occurred earlier for metastatic patients treated with PRT at our institution. Copyright © 2018. Published by Elsevier Inc.

Earlier time to aerobic exercise is associated with faster recovery following acute sport concussion.

PubMed

Lawrence, David Wyndham; Richards, Doug; Comper, Paul; Hutchison, Michael G

2018-01-01

To determine whether earlier time to initiation of aerobic exercise following acute concussion is associated with time to full return to (1) sport and (2) school or work. A retrospective stratified propensity score survival analysis of acute (≤14 days) concussion was used to determine whether time (days) to initiation of aerobic exercise post-concussion was associated with, both, time (days) to full return to (1) sport and (2) school or work. A total of 253 acute concussions [median (IQR) age, 17.0 (15.0-20.0) years; 148 (58.5%) males] were included in this study. Multivariate Cox regression models identified that earlier time to aerobic exercise was associated with faster return to sport and school/work adjusting for other covariates, including quintile propensity strata. For each successive day in delay to initiation of aerobic exercise, individuals had a less favourable recovery trajectory. Initiating aerobic exercise at 3 and 7 days following injury was associated with a respective 36.5% (HR, 0.63; 95% CI, 0.53-0.76) and 73.2% (HR, 0.27; 95% CI, 0.16-0.45) reduced probability of faster full return to sport compared to within 1 day; and a respective 45.9% (HR, 0.54; 95% CI, 0.44-0.66) and 83.1% (HR, 0.17; 95% CI, 0.10-0.30) reduced probability of faster full return to school/work. Additionally, concussion history, symptom severity, LOC deleteriously influenced concussion recovery. Earlier initiation of aerobic exercise was associated with faster full return to sport and school or work. This study provides greater insight into the benefits and safety of aerobic exercise within the first week of the injury.

Dysphoric students show higher use of the observer perspective in their retrieval of positive versus negative autobiographical memories

PubMed Central

Nelis, Sabine; Debeer, Elise; Holmes, Emily A.; Raes, Filip

2013-01-01

Autobiographical memories are retrieved as images from either a field perspective or an observer perspective. The observer perspective is thought to dull emotion. Positive affect is blunted in depressed mood. Consequently, are positive events recalled from an observer perspective in depressed mood? We investigated the relationship between memory vantage perspective and depressive symptoms in a student sample. Participants completed the Autobiographical Memory Test (AMT; Williams & Broadbent, 1986) and assessed the perspective accompanying each memory. The Beck Depression Inventory-II (BDI-II; Beck, Steer, & Brown, 1996) and the Responses to Positive Affect questionnaire (RPA; Feldman, Joormann, & Johnson, 2008) were administered. The results showed a small positive association between depressive symptoms and the use of an observer perspective for positive autobiographical memories, but not for negative memories. Furthermore, comparing a subgroup with clinically significant symptom levels (dysphoric students) with non-dysphoric individuals revealed that dysphoric students used an observer perspective more for positive memories compared with negative memories. This was not the case for non-dysphoric students. The observer perspective in dysphorics was associated with a dampening cognitive style in response to positive experiences. PMID:23083015

Recent gestational diabetes was associated with mothers stopping predominant breastfeeding earlier in a multi-ethnic population.

PubMed

Baerug, Anne; Sletner, Line; Laake, Petter; Fretheim, Atle; Løland, Beate Fossum; Waage, Christin W; Birkeland, Kåre I; Jenum, Anne Karen

2018-06-01

It has previously been shown that breastfeeding may reduce the risk of type 2 diabetes in mothers with recent gestational diabetes mellitus (GDM). This study compared the cessation of predominant breastfeeding in mothers with and without recent GDM in a multi-ethnic population. From May 2008 to May 2010, healthy pregnant women attending antenatal care provided by community health services in Eastern Oslo, Norway were recruited. We included 616 women-58% non-Western-and interviewed and examined them at a mean of 15 and 28 weeks of gestation and 14 weeks' postpartum. Cox regression models examined the association between GDM, as assessed by the 2013 World Health Organization criteria, and breastfeeding cessation. Overall, 190 of the 616 (31%) mothers had GDM and they ended predominant breastfeeding earlier than mothers without GDM, with an adjusted hazard ratio (aHR) of 1.33 and 95% confidence interval (95% CI) of 1.01-1.77. Mothers of South Asian origin ended predominant breastfeeding earlier than Western European mothers in the adjusted analysis (aHR 1.53, 95% CI: 1.04-2.25), but Middle Eastern mothers did not. Recent gestational diabetes was associated with earlier cessation of predominant breastfeeding in Western European and non-Western women. ©2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

Tidal Wave II Revisited: A Review of Earlier Enrollment Projections for California Higher Education.

ERIC Educational Resources Information Center

Hayward, Gerald C.; Breneman, David W.; Estrada, Leobardo F.

This report examined enrollment projections for higher education institutions in California in relation to earlier projections conducted in the mid-1990s that forecasted steep declines in enrollment. It notes that California's remarkable economic recovery over the last several years has allowed it to fund higher education enrollment growth at a…

Variations in a university subject pool as a function of earlier or later participation and self-report: a replication and extension.

PubMed

Bernard, Larry C; Walsh, R Patricia

2002-10-01

The present study replicated and extended earlier research on temporal sampling effects in university subject pools. Data were obtained from 236 participants, 79 men and 157 women, in a university subject pool during a 15-wk. semester. Without knowing the purpose of the study, participants self-selected to participate earlier (Weeks 4 and 5; n = 105) or later (Weeks 14 and 15; n = 131). Three hypotheses were investigated: (1) that the personality patterns of earlier and later participants on the NEO Personality Inventory-Revised and the Personality Research Form differ significantly, with earlier participants scoring higher on the latter scales reflecting social responsibility and higher on former Conscientiousness and Neuroticism scales; (2) that there are similar significant differences between participants in the earlier and later groups compared to the male and female college normative samples for the two tests: and (3) that earlier participants will have higher actual Scholastic Assessment Test scores and Grade Point Averages. Also investigated was whether participants' foreknowledge that their actual Scholastic Assessment Test scores and Grade Point Averages would be obtained would affect their accuracy of self-report. In contrast to prior research, neither the first nor second hypothesis was supported by the current study; there do not appear to be consistent differences on personality variables. However, the third hypothesis was supported. Earlier participants had higher actual high school Grade Point Average, college Grade Point Average, and Scholastic Assessment Test Verbal scores. Foreknowledge that actual Scholastic Assessment Test scores and Grade Point Averages would be obtained did not affect the accuracy of self-report. In addition, later participants significantly over-reported their scores, and significantly more women than men and more first-year than senior-year subjects participated in the early group.

Higher Childhood Red Meat Intake Frequency Is Associated with Earlier Age at Menarche.

PubMed

Jansen, Erica C; Marín, Constanza; Mora-Plazas, Mercedes; Villamor, Eduardo

2016-03-09

Early age at menarche is associated with increased breast cancer risk. Red meat consumption in adolescence predicts breast cancer risk, but it is unknown whether it is also related to earlier menarche. We studied the association between intake of red meat at ages 5-12 y and age at menarche in a prospective study. We assessed usual diets with a food-frequency questionnaire in a group of 456 girls aged 8.4 ± 1.7 y and followed them for a median 5.6 y in Bogotá, Colombia. Girls were asked periodically about the occurrence and date of menarche. Median age at menarche was estimated with use of Kaplan-Meier survival probabilities by categories of red meat intake frequency. Cox proportional hazards models were used to compare the incidence of menarche by red meat intake frequency, adjusting for potential sociodemographic and dietary confounders including total energy intake and intake frequency of other animal food groups (dairy, poultry, freshwater fish, tuna/sardines, eggs, and innards). Median age at menarche was 12.4 y. After adjustment for total energy intake, maternal parity, and socioeconomic status, red meat intake frequency was inversely associated with age at menarche. When compared with girls with red meat intake <4 times/wk, those consuming it ≥2 times/d had a significantly earlier age at menarche (HR: 1.64; 95% CI: 1.11, 2.41; P-trend = 0.0009). Incidentally, we found that girls with tuna/sardine intake >1 time/wk had a significantly later age at menarche (HR: 0.62; 95% CI: 0.42, 0.90; P = 0.01) than those with intake <1 time/mo. Intake frequency of other animal food groups was not significantly associated with age at menarche. Higher red meat intake frequency during childhood is associated with an earlier age at menarche, whereas greater fatty fish intake frequency is associated with a later menarcheal age. © 2016 American Society for Nutrition.

Local Observed-Score Kernel Equating

ERIC Educational Resources Information Center

Wiberg, Marie; van der Linden, Wim J.; von Davier, Alina A.

2014-01-01

Three local observed-score kernel equating methods that integrate methods from the local equating and kernel equating frameworks are proposed. The new methods were compared with their earlier counterparts with respect to such measures as bias--as defined by Lord's criterion of equity--and percent relative error. The local kernel item response…

Retrospective study of reasons for improved survival in patients with breast cancer in east Anglia: earlier diagnosis or better treatment.

PubMed Central

Stockton, D.; Davies, T.; Day, N.; McCann, J.

1997-01-01

OBJECTIVES: To investigate the recent fall in mortality from breast cancer in England and Wales, and to determine the relative contributions of improvements in treatment and earlier detection of tumours. DESIGN: Retrospective study of all women with breast cancer registered by the East Anglian cancer registry and diagnosed between 1982 and 1989. SUBJECTS: 3965 patients diagnosed 1982-5 compared with 4665 patients diagnosed 1986-9, in three age groups 0-49, 50-64, > or = 65 years, with information on stage at diagnosis and survival. MAIN OUTCOME MEASURES: Three year relative survival rates by time period, age group, and stage; relative hazard ratios for each time period and age group derived from Cox's proportional hazards model, adjusted for single year of age and stage. RESULTS: Survival improved in the later time period, although there was little stage specific improvement. The proportion of early stage tumours increased especially in the 50-64 year age group, and adjustment for stage accounted for over half of the improvement in survival in women aged under 65 years. CONCLUSION: Over half of the drop in mortality in women aged under 65 years seems to be attributable to earlier detection of tumours, which has been observed since the mid-1980s. This could have resulted from an increase in breast awareness predating the start of the breast screening programme. PMID:9056796

Clinical presentation of retinoblastoma in Alexandria: A step toward earlier diagnosis.

PubMed

Soliman, Sameh E; Eldomiaty, Wesam; Goweida, Mohamed B; Dowidar, Amgad

2017-01-01

To evaluate the clinical presentation of retinoblastoma in Alexandria, Egypt, correlate the timing of accurate diagnosis with the presence of advanced disease and identify causes of delayed presentation. Retrospective noncomparative single institution study reviews demographic and clinical data of all new children with retinoblastoma presenting to Alexandria Main University ocular oncology clinic (OOC) from January 2012 to June 2014. Diagnosis time was from initial parental complaint to retinoblastoma diagnosis and referral time was from retinoblastoma diagnosis to presentation to the Alexandria OCC. Delayed Diagnosis and referral were counted if >2 weeks. Advanced presentation is defined as clinical TNMH (8th edition) staging of cT2 or cT3 (international intraocular retinoblastoma classification group D or E) in at least one eye or the presence of extra-ocular disease (cT4). Seventy eyes of 47 children were eligible: 52% unilateral, 7% with family history and 96% presented with leukocorea. Sixty-four percent of children had advanced intraocular disease and none had extra-ocular disease. Delayed presentation occurred in 58% of children and was significantly associated with advanced disease in both unilaterally and bilaterally affected children (p = 0.003, 0.002 respectively). The delay in diagnosis was more in unilateral cases while the delay in referral was more in bilateral cases. The main cause of delayed presentation in unilateral retinoblastoma was misdiagnosis (30%) while parental shopping for second medical opinion (30%) was the main cause in bilateral children. Delayed diagnosis is a problem affecting retinoblastoma management. Better medical education and training, health education and earlier screening are recommended to achieve earlier diagnosis.

A survey of local interstellar hydrogen from OAO-2 observations of Lyman alpha absorption

NASA Technical Reports Server (NTRS)

Savage, B. D.; Jenkins, E. B.

1972-01-01

The Wisconsin far ultraviolet spectrometer aboard OAO-2 observed the wavelength region near 1216 A for 69 stars of spectral type B2 or earlier. From the strength of the observed interstellar L sub alpha absorption, atomic hydrogen column densities were derived over distances averaging 300 pc away from the sun. The OAO data were compared to synthetic ultraviolet spectra, originally derived from earlier higher resolution rocket observations, which were computer processed to simulate the effects of absorption by different amounts of hydrogen followed by the instrumental blending.

Earlier time to aerobic exercise is associated with faster recovery following acute sport concussion

PubMed Central

Richards, Doug; Comper, Paul; Hutchison, Michael G.

2018-01-01

Objective To determine whether earlier time to initiation of aerobic exercise following acute concussion is associated with time to full return to (1) sport and (2) school or work. Methods A retrospective stratified propensity score survival analysis of acute (≤14 days) concussion was used to determine whether time (days) to initiation of aerobic exercise post-concussion was associated with, both, time (days) to full return to (1) sport and (2) school or work. Results A total of 253 acute concussions [median (IQR) age, 17.0 (15.0–20.0) years; 148 (58.5%) males] were included in this study. Multivariate Cox regression models identified that earlier time to aerobic exercise was associated with faster return to sport and school/work adjusting for other covariates, including quintile propensity strata. For each successive day in delay to initiation of aerobic exercise, individuals had a less favourable recovery trajectory. Initiating aerobic exercise at 3 and 7 days following injury was associated with a respective 36.5% (HR, 0.63; 95% CI, 0.53–0.76) and 73.2% (HR, 0.27; 95% CI, 0.16–0.45) reduced probability of faster full return to sport compared to within 1 day; and a respective 45.9% (HR, 0.54; 95% CI, 0.44–0.66) and 83.1% (HR, 0.17; 95% CI, 0.10–0.30) reduced probability of faster full return to school/work. Additionally, concussion history, symptom severity, LOC deleteriously influenced concussion recovery. Conclusion Earlier initiation of aerobic exercise was associated with faster full return to sport and school or work. This study provides greater insight into the benefits and safety of aerobic exercise within the first week of the injury. PMID:29668716

Factors associated with late diagnosis of HIV infection and missed opportunities for earlier testing.

PubMed

Gullón, Alejandra; Verdejo, José; de Miguel, Rosa; Gómez, Ana; Sanz, Jesús

2016-10-01

Late diagnosis (LD) of human immunodeficiency virus (HIV) infection continues to be a significant problem that increases disease burden both for patients and for the public health system. Guidelines have been updated in order to facilitate earlier HIV diagnosis, introducing "indicator condition-guided HIV testing". In this study, we analysed the frequency of LD and associated risk factors. We retrospectively identified those cases that could be considered missed opportunities for an earlier diagnosis. All patients newly diagnosed with HIV infection who attended Hospital La Princesa, Madrid (Spain) between 2007 and 2014 were analysed. We collected epidemiological, clinical and immunological data. We also reviewed electronic medical records from the year before the HIV diagnosis to search for medical consultations due to clinical indicators. HIV infection was diagnosed in 354 patients. The median CD4 count at presentation was 352 cells/mm(3). Overall, 158 patients (50%) met the definition of LD, and 97 (30.7%) the diagnosis of advanced disease. LD was associated with older age and was more frequent amongst immigrants. Heterosexual relations and injection drug use were more likely to be the reasons for LD than relations between men who have sex with men. During the year preceding the diagnosis, 46.6% of the patients had sought medical advice owing to the presence of clinical indicators that should have led to HIV testing. Of those, 24 cases (14.5%) were classified as missed opportunities for earlier HIV diagnosis because testing was not performed. According to these results, all health workers should pursue early HIV diagnosis through the proper implementation of HIV testing guidelines. Such an approach would prove directly beneficial to the patient and indirectly beneficial to the general population through the reduction in the risk of transmission.

A Luenberger observer for reaction-diffusion models with front position data

NASA Astrophysics Data System (ADS)

Collin, Annabelle; Chapelle, Dominique; Moireau, Philippe

2015-11-01

We propose a Luenberger observer for reaction-diffusion models with propagating front features, and for data associated with the location of the front over time. Such models are considered in various application fields, such as electrophysiology, wild-land fire propagation and tumor growth modeling. Drawing our inspiration from image processing methods, we start by proposing an observer for the eikonal-curvature equation that can be derived from the reaction-diffusion model by an asymptotic expansion. We then carry over this observer to the underlying reaction-diffusion equation by an ;inverse asymptotic analysis;, and we show that the associated correction in the dynamics has a stabilizing effect for the linearized estimation error. We also discuss the extension to joint state-parameter estimation by using the earlier-proposed ROUKF strategy. We then illustrate and assess our proposed observer method with test problems pertaining to electrophysiology modeling, including with a realistic model of cardiac atria. Our numerical trials show that state estimation is directly very effective with the proposed Luenberger observer, while specific strategies are needed to accurately perform parameter estimation - as is usual with Kalman filtering used in a nonlinear setting - and we demonstrate two such successful strategies.

The Sooner, the Worse? Association between Earlier Age of Sexual Initiation and Worse Adolescent Health and Well-being Outcomes

PubMed Central

Osorio, Alfonso; Lopez-del Burgo, Cristina; Carlos, Silvia; de Irala, Jokin

2017-01-01

This cross-sectional study assesses the association between age of sexual initiation during adolescence and a selection of well-being outcomes regarding that first relationship. High-school adolescents from El Salvador (2,686) and from Peru (3,399) replied to a paper-pencil questionnaire. Those who were sexually initiated replied to several questions regarding their age at sexual initiation, condom use, satisfaction and reasons/circumstances for that sexual relationship. Approximately 19% of participants were sexually initiated (n = 1,179). After retaining participants with valid responses and with sexual initiation ages between 13 and 17, the final sample for this paper consisted of 996 sexually initiated participants (526 Salvadorians and 470 Peruvians). Multiple logistic regression analyses showed that those who initiated sex at earlier ages had worse outcomes compared to those who initiated at older ages. Specifically, they had lower odds of having used a condom, of having good memories of that experience and of having had that first relationship because they were in love. Conversely, they had higher odds of having had that first sexual relationship as a result of peer pressure (“Most of my friends already had sex”), because of partner pressure (“I was afraid to lose him/her,” “My partner told me he/she would leave me” or “I did not know how to say no to a person who insisted”), or as a consequence of different forms of impaired autonomy (“I was under the influence of alcohol or drugs” or “As a consequence of seeing sexual images”). Results show that sex at earlier ages is associated with worse adolescent health and well-being outcomes. PMID:28798715

Return of hunger following a relatively high carbohydrate breakfast is associated with earlier recorded glucose peak and nadir

PubMed Central

Chandler-Laney, Paula C.; Morrison, Shannon A.; Goree, Laura Lee T.; Ellis, Amy C.; Casazza, Krista; Desmond, Renee; Gower, Barbara A

2014-01-01

Objective To test the hypothesis that a breakfast meal with high carbohydrate/ low fat results in an earlier increase in postprandial glucose and insulin, a greater decrease below baseline in postprandial glucose, and an earlier return of appetite, compared to a low carbohydrate/high fat meal. Design Overweight but otherwise healthy adults (n=64) were maintained on one of two eucaloric diets: high carbohydrate/low fat (HC/LF; 55:27:18% kcals from carbohydrate: fat: protein) versus low carbohydrate/high fat (LC/HF; 43:39:18% kcals from carbohydrate: fat: protein). After 4 weeks of acclimation to the diets, participants underwent a meal test during which circulating glucose and insulin and self-reported hunger and fullness, were measured before and after consumption of breakfast from their assigned diets. Results The LC/HF meal resulted in a later time at the highest and lowest recorded glucose, higher glucose concentrations at 3 and 4 hours post-meal, and lower insulin incremental area under the curve. Participants consuming the LC/HF meal reported lower appetite 3 and 4 hours following the meal, a response that was associated with the timing of the highest and lowest recorded glucose. Conclusions Modest increases in meal carbohydrate content at the expense of fat content may facilitate weight gain over the long-term by contributing to an earlier rise and fall of postprandial glucose concentrations and an earlier return of appetite. PMID:24819342

Goddard Celebrates International Observe the Moon Night with Laser Show

NASA Image and Video Library

2017-12-08

Goddard's Laser Ranging Facility directs a laser toward the Lunar Reconassaince Orbiter on International Observe the Moon Night. (Sept 18, 2010) Background on laser ranging: www.nasa.gov/mission_pages/LRO/news/LRO_lr.html Information on inOMN www.nasa.gov/centers/goddard/news/features/2010/moon-nigh... Credit: NASA/GSFC NASA Goddard Space Flight Center contributes to NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s endeavors by providing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Join us on Facebook

EE Cep observations requested for upcoming eclipse

NASA Astrophysics Data System (ADS)

Waagen, Elizabeth O.

2014-07-01

The AAVSO requests observations for the upcoming eclipse of EE Cephei, a long-period eclipsing variable. EE Cep has a period of 2,050 days, and shows strong variations in the eclipse light curve from one event to the next. Observations are needed to study the morphology of the upcoming eclipse, which will be used to better understand the shape of the eclipsing disk and how it precesses. Mid-eclipse is predicted to be August 23, 2014, but the early stages of the eclipse may begin as much as a month earlier. EE Cep is being observed by a number of amateur and professional astronomers using multiple telescopes at multiple wavelengths. Among these is a collaboration (see https://sites.google.com/site/eecep2014campaign/) headed by Cezary Galan at the Nicolaus Copernicus Astronomical Center in Poland; several individual AAVSO observers are already participating in this effort. The AAVSO is not currently a partner in that campaign, but all data submitted to the AAVSO will be publicly available. The AAVSO strongly encourages observers to begin following this star now, and to continue observations into October 2014 at least. Finder charts with sequence may be created using the AAVSO Variable Star Plotter (http://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. See full Alert Notice for more details and observations.

Preoperative left ventricular internal dimension in end-diastole as earlier identification of early patent ductus arteriosus operation and postoperative intensive care in very low birth weight infants.

PubMed

Saida, Ken; Nakamura, Tomohiko; Hiroma, Takehiko; Takigiku, Kiyohiro; Yasukochi, Satoshi

2013-10-01

Patent ductus arteriosus (PDA) is common in premature infants. In very low birth weight infants (VLBWI), PDA requires surgical therapy in many cases. It is unclear to know at-risk infants showing cardio-dysfunction after PDA surgery. The purpose of this study was to identify at-risk infants showing cardio-dysfunction after surgery for patent ductus arteriosus (PDA). We examined the relationship between left ventricular (LV) performance before and after PDA ligation in a retrospective observational cohort study. We studied 64 preterm neonates with symptomatic PDA before and after surgical ligation. Echocardiographic examinations were performed pre- and postoperatively. M-mode measurements included left ventricular internal dimension in end-diastole (LVIDd) and LV fractional shortening (FS). All cases showed decreased LVFS after PDA closure. Most cases (49/64, 77%) showed postoperative FS decreased to below normal (<28%). Preoperative relative LVIDd was significantly larger in abnormal FS infants (137 ± 18%) than in normal FS infants (118 ± 11%; p<0.01). A cut-off value of preoperative relative LVIDd (absolute LVIDd/normal value) for predicting postoperative cardio-dysfunction was 127.4% (sensitivity, 0.735; specificity, 0.933; area under curve, 0.817). Determination of preoperative LVIDd might facilitate earlier identification of infants needing early PDA surgery and postoperative intensive care. © 2013 Elsevier Ireland Ltd. All rights reserved.

Identified research directions for using manufacturing knowledge earlier in the product lifecycle

PubMed Central

Hedberg, Thomas D.; Hartman, Nathan W.; Rosche, Phil; Fischer, Kevin

2016-01-01

Design for Manufacturing (DFM), especially the use of manufacturing knowledge to support design decisions, has received attention in the academic domain. However, industry practice has not been studied enough to provide solutions that are mature for industry. The current state of the art for DFM is often rule-based functionality within Computer-Aided Design (CAD) systems that enforce specific design requirements. That rule-based functionality may or may not dynamically affect geometry definition. And, if rule-based functionality exists in the CAD system, it is typically a customization on a case-by-case basis. Manufacturing knowledge is a phrase with vast meanings, which may include knowledge on the effects of material properties decisions, machine and process capabilities, or understanding the unintended consequences of design decisions on manufacturing. One of the DFM questions to answer is how can manufacturing knowledge, depending on its definition, be used earlier in the product lifecycle to enable a more collaborative development environment? This paper will discuss the results of a workshop on manufacturing knowledge that highlights several research questions needing more study. This paper proposes recommendations for investigating the relationship of manufacturing knowledge with shape, behavior, and context characteristics of product to produce a better understanding of what knowledge is most important. In addition, the proposal includes recommendations for investigating the system-level barriers to reusing manufacturing knowledge and how model-based manufacturing may ease the burden of knowledge sharing. Lastly, the proposal addresses the direction of future research for holistic solutions of using manufacturing knowledge earlier in the product lifecycle. PMID:27990027

Identified research directions for using manufacturing knowledge earlier in the product lifecycle.

PubMed

Hedberg, Thomas D; Hartman, Nathan W; Rosche, Phil; Fischer, Kevin

2017-01-01

Design for Manufacturing (DFM), especially the use of manufacturing knowledge to support design decisions, has received attention in the academic domain. However, industry practice has not been studied enough to provide solutions that are mature for industry. The current state of the art for DFM is often rule-based functionality within Computer-Aided Design (CAD) systems that enforce specific design requirements. That rule-based functionality may or may not dynamically affect geometry definition. And, if rule-based functionality exists in the CAD system, it is typically a customization on a case-by-case basis. Manufacturing knowledge is a phrase with vast meanings, which may include knowledge on the effects of material properties decisions, machine and process capabilities, or understanding the unintended consequences of design decisions on manufacturing. One of the DFM questions to answer is how can manufacturing knowledge, depending on its definition, be used earlier in the product lifecycle to enable a more collaborative development environment? This paper will discuss the results of a workshop on manufacturing knowledge that highlights several research questions needing more study. This paper proposes recommendations for investigating the relationship of manufacturing knowledge with shape, behavior, and context characteristics of product to produce a better understanding of what knowledge is most important. In addition, the proposal includes recommendations for investigating the system-level barriers to reusing manufacturing knowledge and how model-based manufacturing may ease the burden of knowledge sharing. Lastly, the proposal addresses the direction of future research for holistic solutions of using manufacturing knowledge earlier in the product lifecycle.

Inevitable end-of-21st-century trends toward earlier surface runoff timing in California's Sierra Nevada Mountains

NASA Astrophysics Data System (ADS)

Schwartz, M. A.; Hall, A. D.; Sun, F.; Walton, D.; Berg, N.

2015-12-01

Hybrid dynamical-statistical downscaling is used to produce surface runoff timing projections for California's Sierra Nevada, a high-elevation mountain range with significant seasonal snow cover. First, future climate change projections (RCP8.5 forcing scenario, 2081-2100 period) from five CMIP5 global climate models (GCMs) are dynamically downscaled. These projections reveal that future warming leads to a shift toward earlier snowmelt and surface runoff timing throughout the Sierra Nevada region. Relationships between warming and surface runoff timing from the dynamical simulations are used to build a simple statistical model that mimics the dynamical model's projected surface runoff timing changes given GCM input or other statistically-downscaled input. This statistical model can be used to produce surface runoff timing projections for other GCMs, periods, and forcing scenarios to quantify ensemble-mean changes, uncertainty due to intermodel variability and consequences stemming from choice of forcing scenario. For all CMIP5 GCMs and forcing scenarios, significant trends toward earlier surface runoff timing occur at elevations below 2500m. Thus, we conclude that trends toward earlier surface runoff timing by the end-of-the-21st century are inevitable. The changes to surface runoff timing diagnosed in this study have implications for many dimensions of climate change, including impacts on surface hydrology, water resources, and ecosystems.

A comprehensive review of observational and site evaluation data of migrant whooping cranes in the United States, 1943-1999

USGS Publications Warehouse

Austin, Jane E.; Richert, Amy L.

2001-01-01

This report is a comprehensive analysis of existing observational data (1943–99) and site evaluation data (1977–99) for locations used by whooping cranes (Grus americana) during migration through the United States portion of the Wood Buffalo–Aransas flyway. The apparent migration path, as outlined by the distribution of whooping crane observations, is very similar to that delineated in earlier reports, following a relatively straight line north-northwest from Aransas National Wildlife Refuge (NWR) to central North Dakota then curving northwest along the Missouri Coteau to the North Dakota–Saskatchewan border. The distribution of spring and fall observations were relatively similar, except for the higher frequency of fall observations on Quivira NWR and Cheyenne Bottoms State Wildlife Area in Kansas, Salt Plains NWR in Oklahoma, and in Texas. Timing of spring and fall migrations also appears similar to that described earlier and shows no changes over the 57-year period of data collection. Regardless of season, most sightings included 1–3 whooping cranes, but groups with as many as 14 and 19 cranes have been sighted in spring and fall, respectively.

Screening for Colorectal Cancer in African Americans: Determinants and Rationale for an Earlier Age to Commence Screening

PubMed Central

Carethers, John M.

2014-01-01

Colorectal cancer (CRC) screening is a highly cost-effective approach to reduce morbidity and mortality of patients, as well as reduce the prevalence of CRC in populations. Current recommendations for CRC screening for the asymptomatic general population begin at age 50 years, an age after which ~95% of cancers occur. Determinants that modify the timing and frequency for screening include a personal or family history of adenomatous polyps or CRC, the age of onset of these colonic lesions, and the presence or potential for a patient to harbor a higher-risk syndrome such as inflammatory bowel disease (IBD), familial adenomatous polyposis (FAP), or Lynch syndrome.. Although race, like family history, is a heritable factor, it has not engendered inclusion in the same broad systematic screening recommendations despite multiple studies demonstrating a disparity in the incidence and mortality from CRC, and the potential for targeted screening to reduce the disparity. In particular, African Americans, when compared to Caucasians, (a) have lower CRC screening utilization rates, (b) have an earlier presentation of CRC (0-8 years younger than Caucasians) and, more often have aggressive biological features more prone to metastasis, (c) have a higher CRC prevalence at all ages and a higher proportion of CRCs before 50 years of age (~11% vs 5% in Caucasians), (d) are less likely to know or transmit personal or family history of adenomas or CRC that might change their screening to an earlier age, (e) present with 7-15% excess right-sided CRCs that are not microsatellite unstable, (f) show higher frequencies of high-risk adenomas at every decile of age, and an excess of high-risk proximal adenomas that mirror the excess of proximal CRCs, (g) have cancers that demonstrate lower proportions of good prognostic biomarkers such as MSI and higher proportions of bad prognosticators such as EMAST, (h) may possess gut microbiota more conducive to initiating and/or propagating colonic

Earlier Visual N1 Latencies in Expert Video-Game Players: A Temporal Basis of Enhanced Visuospatial Performance?

PubMed Central

Latham, Andrew J.; Patston, Lucy L. M.; Westermann, Christine; Kirk, Ian J.; Tippett, Lynette J.

2013-01-01

Increasing behavioural evidence suggests that expert video game players (VGPs) show enhanced visual attention and visuospatial abilities, but what underlies these enhancements remains unclear. We administered the Poffenberger paradigm with concurrent electroencephalogram (EEG) recording to assess occipital N1 latencies and interhemispheric transfer time (IHTT) in expert VGPs. Participants comprised 15 right-handed male expert VGPs and 16 non-VGP controls matched for age, handedness, IQ and years of education. Expert VGPs began playing before age 10, had a minimum 8 years experience, and maintained playtime of at least 20 hours per week over the last 6 months. Non-VGPs had little-to-no game play experience (maximum 1.5 years). Participants responded to checkerboard stimuli presented to the left and right visual fields while 128-channel EEG was recorded. Expert VGPs responded significantly more quickly than non-VGPs. Expert VGPs also had significantly earlier occipital N1s in direct visual pathways (the hemisphere contralateral to the visual field in which the stimulus was presented). IHTT was calculated by comparing the latencies of occipital N1 components between hemispheres. No significant between-group differences in electrophysiological estimates of IHTT were found. Shorter N1 latencies may enable expert VGPs to discriminate attended visual stimuli significantly earlier than non-VGPs and contribute to faster responding in visual tasks. As successful video-game play requires precise, time pressured, bimanual motor movements in response to complex visual stimuli, which in this sample began during early childhood, these differences may reflect the experience and training involved during the development of video-game expertise, but training studies are needed to test this prediction. PMID:24058667

Earlier visual N1 latencies in expert video-game players: a temporal basis of enhanced visuospatial performance?

PubMed

Latham, Andrew J; Patston, Lucy L M; Westermann, Christine; Kirk, Ian J; Tippett, Lynette J

2013-01-01

Increasing behavioural evidence suggests that expert video game players (VGPs) show enhanced visual attention and visuospatial abilities, but what underlies these enhancements remains unclear. We administered the Poffenberger paradigm with concurrent electroencephalogram (EEG) recording to assess occipital N1 latencies and interhemispheric transfer time (IHTT) in expert VGPs. Participants comprised 15 right-handed male expert VGPs and 16 non-VGP controls matched for age, handedness, IQ and years of education. Expert VGPs began playing before age 10, had a minimum 8 years experience, and maintained playtime of at least 20 hours per week over the last 6 months. Non-VGPs had little-to-no game play experience (maximum 1.5 years). Participants responded to checkerboard stimuli presented to the left and right visual fields while 128-channel EEG was recorded. Expert VGPs responded significantly more quickly than non-VGPs. Expert VGPs also had significantly earlier occipital N1s in direct visual pathways (the hemisphere contralateral to the visual field in which the stimulus was presented). IHTT was calculated by comparing the latencies of occipital N1 components between hemispheres. No significant between-group differences in electrophysiological estimates of IHTT were found. Shorter N1 latencies may enable expert VGPs to discriminate attended visual stimuli significantly earlier than non-VGPs and contribute to faster responding in visual tasks. As successful video-game play requires precise, time pressured, bimanual motor movements in response to complex visual stimuli, which in this sample began during early childhood, these differences may reflect the experience and training involved during the development of video-game expertise, but training studies are needed to test this prediction.

Design a Fuzzy Rule-based Expert System to Aid Earlier Diagnosis of Gastric Cancer.

PubMed

Safdari, Reza; Arpanahi, Hadi Kazemi; Langarizadeh, Mostafa; Ghazisaiedi, Marjan; Dargahi, Hossein; Zendehdel, Kazem

2018-01-01

Screening and health check-up programs are most important sanitary priorities, that should be undertaken to control dangerous diseases such as gastric cancer that affected by different factors. More than 50% of gastric cancer diagnoses are made during the advanced stage. Currently, there is no systematic approach for early diagnosis of gastric cancer. to develop a fuzzy expert system that can identify gastric cancer risk levels in individuals. This system was implemented in MATLAB software, Mamdani inference technique applied to simulate reasoning of experts in the field, a total of 67 fuzzy rules extracted as a rule-base based on medical expert's opinion. 50 case scenarios were used to evaluate the system, the information of case reports is given to the system to find risk level of each case report then obtained results were compared with expert's diagnosis. Results revealed that sensitivity was 92.1% and the specificity was 83.1%. The results show that is possible to develop a system that can identify High risk individuals for gastric cancer. The system can lead to earlier diagnosis, this may facilitate early treatment and reduce gastric cancer mortality rate.

Radar observations of the Geminid meteoroid stream

NASA Astrophysics Data System (ADS)

Cevolani, G.; Bortolotti, G.; Foschini, L.; Franceschi, C.; Grassi, G.; Trivellone, G.

1994-08-01

Continuous radio-wave monitoring of the Geminid activity in December 1992 and 1993 by using a forward-scatter (FS) bistatic radar over the Bologna-Lecce baseline (700 km) in Italy, reveals peculiar structural aspects of the stream in terms of signal amplitude-rate and duration-rate dependence. The observational results of the Geminid display obtained in the two consecutive years with differentiated peak levels of transmitted power, exhibit different time distributions of underdense meteors against the signal received power. Both sets of data relative to the peak activity in December 12-14, show reflection properties of Geminids which are atypical if compared with echoes from cometary-type showers, with really high echo counts at mid-upper levels of the peak received power. A comparison with the records of 1986 Geminids at the Budrio backscatter radar station near Bologna, shows an asymmetric curve of activity, with smaller particles shifted to shorter and less eccentric orbits, the peak flux occurring earlier than that of larger ones.

Observations concerning the generation and propagation of Type III solar bursts

NASA Technical Reports Server (NTRS)

Kellogg, P. J.

1986-01-01

A number of Type III bursts were observed during the Helios missions in which the burst exciter passed over the spacecraft, as evidenced by strong electric field fluctuations near the plasma frequency. Six of these were suitable for detailed study. Of the six events, one was ambiguous, one showed what is interpreted as a switchover from harmonic to fundamental, and the rest all generated fundamental at onset. This would be expected if both fundamental and harmonic are generated, as, at a fixed frequency, the fundamental will be generated earlier. For the event which seems to show both fundamental and harmonic emission, the frequency ratio is not exactly 2. This is explained in terms of a time delay of the fundamental, due to scattering and diffusion in the source region. A time delay of the order of 600 seconds at 1 AU and 20 kHz, and inversely proportional to frequency, is required to explain the observations. Crude estimates show that delay times at least this long may be attributed to trapping and scattering.

Advanced seasonal reproductive development in a male urban bird is reflected in earlier plasma luteinizing hormone rise but not energetic status.

PubMed

Davies, Scott; Behbahaninia, Hirbod; Giraudeau, Mathieu; Meddle, Simone L; Waites, Kyle; Deviche, Pierre

2015-12-01

Urban animals inhabit an environment considerably different than do their non-urban conspecifics, and to persist urban animals must adjust to these novel environments. The timing of seasonal reproductive development (i.e., growth of gonads and secondary sex organs) is a fundamental determinant of the breeding period and is frequently advanced in urban bird populations. However, the underlying mechanism(s) by which birds adjust the timing of reproductive development to urban areas remain(s) largely unknown. Here, we compared the timing of vernal reproductive development in free-ranging urban and non-urban male Abert's Towhees, Melozone aberti, in Phoenix, Arizona, USA, and tested the non-mutually exclusive hypotheses that earlier reproductive development is due to improved energetic status and/or earlier increase in endocrine activity of the reproductive system. We found that urban birds initiated testicular development earlier than non-urban birds, but this disparity was not associated with differences in body condition, fat stores, or innate immune performance. These results provide no support for the hypothesis that energetic constraints are responsible for delayed reproductive development of non-urban relative to urban male Abert's Towhees. Urban birds did, however, increase their plasma luteinizing hormone, but not plasma testosterone, earlier than non-urban birds. These findings suggest that adjustment to urban areas by Abert's Towhees involves increases in the endocrine activity of the anterior pituitary gland and/or hypothalamus earlier than non-urban towhees. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

5 CFR Appendix A to Subpart C of... - Present Value Conversion Factors for Earlier Commencing Date of Annuities of Current and Former...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Present Value Conversion Factors for Earlier Commencing Date of Annuities of Current and Former Spouses of Deceased Separated Employees A...—Present Value Conversion Factors for Earlier Commencing Date of Annuities of Current and Former Spouses of...

Organized screening detects breast cancer at earlier stage regardless of molecular phenotype.

PubMed

Holloway, Claire M B; Jiang, Li; Whitehead, Marlo; Racz, Jennifer M; Groome, Patti A

2018-06-16

Mortality reduction attributable to organized breast screening is modest. Screening may be less effective at detecting more aggressive cancers at an earlier stage. This study was conducted to determine the relative efficacy of screening mammography to detect cancers at an earlier stage by molecular phenotype. We identified 2882 women with primary invasive breast cancer diagnosed between January 1, 2008 and December 31, 2012 and who had a mammogram through the Ontario Breast Screening Program in the 28 months before diagnosis. Five tumor phenotypes were defined by expression of estrogen (ER) and progesterone (PR) receptors and HER2/neu oncogene. We conducted univariable and multivariable analyses to describe the predictors of detection as an interval cancer. Additional analyses identified predictors of detection at stages II, III, or IV compared with stage I, by phenotype. Analyses were adjusted for the effects of age, grade, and breast density. ER negative and HER2 positive tumors were over-represented among interval cancers, and triple negative cancers were more likely than ER +/HER2 - cancers to be detected as interval cancers OR 2.5 (95% CI 2.0-3.2, p < 0.0001). Method of detection (interval vs. screen) and molecular phenotype were independently associated with stage at diagnosis (p < 0.0001), but there was no interaction between method of detection and phenotype (p = 0.44). In a screened population, triple negative and HER2 + breast cancers are diagnosed at a higher stage but this appears to be due to higher growth rates of these tumors rather than a relative inability of screening to detect them.

A primary care Web-based Intervention Modeling Experiment replicated behavior changes seen in earlier paper-based experiment.

PubMed

Treweek, Shaun; Francis, Jill J; Bonetti, Debbie; Barnett, Karen; Eccles, Martin P; Hudson, Jemma; Jones, Claire; Pitts, Nigel B; Ricketts, Ian W; Sullivan, Frank; Weal, Mark; MacLennan, Graeme

2016-12-01

Intervention Modeling Experiments (IMEs) are a way of developing and testing behavior change interventions before a trial. We aimed to test this methodology in a Web-based IME that replicated the trial component of an earlier, paper-based IME. Three-arm, Web-based randomized evaluation of two interventions (persuasive communication and action plan) and a "no intervention" comparator. The interventions were designed to reduce the number of antibiotic prescriptions in the management of uncomplicated upper respiratory tract infection. General practitioners (GPs) were invited to complete an online questionnaire and eight clinical scenarios where an antibiotic might be considered. One hundred twenty-nine GPs completed the questionnaire. GPs receiving the persuasive communication did not prescribe an antibiotic in 0.70 more scenarios (95% confidence interval [CI] = 0.17-1.24) than those in the control arm. For the action plan, GPs did not prescribe an antibiotic in 0.63 (95% CI = 0.11-1.15) more scenarios than those in the control arm. Unlike the earlier IME, behavioral intention was unaffected by the interventions; this may be due to a smaller sample size than intended. A Web-based IME largely replicated the findings of an earlier paper-based study, providing some grounds for confidence in the IME methodology. Copyright © 2016 Elsevier Inc. All rights reserved.

White shrimp Litopenaeus vannamei that had received the hot-water extract of Spirulina platensis showed earlier recovery in immunity and up-regulation of gene expressions after pH stress.

PubMed

Lin, Yong-Chin; Tayag, Carina Miranda; Huang, Chien-Lun; Tsui, Wen-Ching; Chen, Jiann-Chu

2010-12-01

White shrimp Litopenaeus vannamei which had been immersed in seawater (35‰, pH 8.2) containing the hot-water extract of Spirulina platensis at 0 (control), 200, 400, and 600 mg L(-1) for 3 h, were transferred to seawater at pH 6.8, and the immune parameters and transcripts of the lipopolysaccharide- and β-glucan-binding protein (LGBP), peroxinectin (PX), and integrin β (IB) were examined 6-96 h post-transfer. Shrimp with no exposure to the hot-water extract and no pH change served as the background control. Results indicated that the hyaline cells, granular cells (including semi-granular cells), total haemocyte count, phenoloxidase activity, respiratory burst, superoxide dismutase activity, glutathione peroxidase activity, and lysozyme activity of shrimp transferred to seawater at pH 6.8 significantly decreased to the lowest at 6 h post-transfer. These immune parameters of shrimp immersed in 600 mg L(-1) of the extract were significantly higher than those of control shrimp at 24-96 h post-transfer, and had returned to the background values earlier at 48-72 h post-transfer with significant transcripts of LGBP, PX, and IB at 24, 6, and 24 h, respectively, whereas these parameters of control shrimp returned to the original values at ≥96 h post-transfer. Copyright © 2010 Elsevier Ltd. All rights reserved.

Delusions and underlying needs in older adults with Alzheimer's disease: influence of earlier life experiences and the current environment.

PubMed

Wang, Jing-Jy; Cheng, Wen-Yun; Lai, Pei-Ru; Pai, Ming-Chyi

2014-12-01

Delusions are one of the most severe psychiatric symptoms of individuals with Alzheimer's disease (AD), which often increase the stress experienced by caregivers. The purpose of this study was to understand the influences of earlier life experiences and the current environment on delusions, as well as the underlying needs of older adults with AD who experience delusions. Using an exploratory research design with a qualitative approach and purposive sampling, 20 family caregivers were interviewed. Two psychosocial types of attributes of delusion were categorized: Type A, the influence of earlier life experiences; and Type B, current environmental influences. The underlying needs of those with delusions include physical comfort, a desire to be secure, and a sense of belonging. The contents of delusions are easily influenced by patients' earlier negative experiences and responsibilities, whereas the current environment exerts a crucial influence on the occurrence, frequency, and severity of specific delusions. These results can facilitate planning for patient-centered care by enhancing health care providers' understanding of the psychosocial and environmental attributes and needs behind delusions. Copyright 2014, SLACK Incorporated.

Observers for Systems with Nonlinearities Satisfying an Incremental Quadratic Inequality

NASA Technical Reports Server (NTRS)

Acikmese, Ahmet Behcet; Corless, Martin

2004-01-01

We consider the problem of state estimation for nonlinear time-varying systems whose nonlinearities satisfy an incremental quadratic inequality. These observer results unifies earlier results in the literature; and extend it to some additional classes of nonlinearities. Observers are presented which guarantee that the state estimation error exponentially converges to zero. Observer design involves solving linear matrix inequalities for the observer gain matrices. Results are illustrated by application to a simple model of an underwater.

Dendrophenology: Inferring the response of North American eastern deciduous forests to an earlier spring from tree rings

NASA Astrophysics Data System (ADS)

Elmore, A. J.; Nelson, D. M.; Craine, J. M.

2016-12-01

There is wide agreement that anthropogenic climate warming has influenced the phenology of forests during the late twentieth and early twenty-first centuries. A critical question for predicting the magnitude of future warming under different emissions scenarios is the degree to which forest productivity responds to longer growing seasons in the face of concurrent changes in other drivers of productivity. Longer growing seasons can lead to increased photosynthesis and productivity, which would represent a negative feedback to rising CO2 and consequently warming. Alternatively, increased demand for soil resources due to a longer photosynthetically active period in conjunction with other global change factors might exacerbate resource limitation, restricting forest productivity response to a longer growing season. In this case, increased spring-time productivity has the potential to increase plant N limitation by increasing plant demand for N more than N supplies, or increasing early-season ecosystem N losses. Long-term direct measurements are not yet available to specifically address this question, but advances in remote sensing and dendroecological methods present opportunities to acquire information retrospectively to advance understanding of how phenological changes and resource availability to trees have been affecting forest productivity. Here we show that for 222 trees representing three species in eastern North America over the past 30 years earlier spring phenology has caused declines in N availability to trees by increasing demand for N relative to supply. The observed decline in N availability is not associated with reduced wood production, suggesting that other environmental changes such as increased atmospheric CO2 and water availability have likely overwhelmed reduced N availability. Given current trajectories of environmental changes, N limitation will likely continue to increase for these forests, possibly further limiting C sequestration potential.

37 CFR 1.78 - Claiming benefit of earlier filing date and cross-references to other applications.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Claiming benefit of earlier filing date and cross-references to other applications. 1.78 Section 1.78 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN...

37 CFR 1.78 - Claiming benefit of earlier filing date and cross-references to other applications.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Claiming benefit of earlier filing date and cross-references to other applications. 1.78 Section 1.78 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN...

Comparison of Forecast and Observed Energetics

NASA Technical Reports Server (NTRS)

Baker, W. E.; Brin, Y.

1985-01-01

An energetics analysis scheme was developed to compare the observed kinetic energy balance over North America with that derived from forecast cyclone case. It is found that: (1) the observed and predicted kinetic energy and eddy conversion are in good qualitative agreement, although the model eddy conversion tends to be 2 to 3 times stronger than the observed values. The eddy conversion which is stronger in the 12 h forecast than in observations and may be due to several factors is studied; (2) vertical profiles of kinetic energy generation and dissipation exhibit lower and upper tropospheric maxima in both the forecast and observations; and (3) a lag in the observational analysis with the maximum in the observed kinetic energy occurring at 0000 GMT 14 January over the same region as the maximum Eddy conversion 12 h earlier is noted.

Selection for Earlier Flowering Crop Associated with Climatic Variations in the Sahel

PubMed Central

Vigouroux, Yves; Mariac, Cédric; De Mita, Stéphane; Pham, Jean-Louis; Gérard, Bruno; Kapran, Issoufou; Sagnard, Fabrice; Deu, Monique; Chantereau, Jacques; Ali, Abdou; Ndjeunga, Jupiter; Luong, Viviane; Thuillet, Anne-Céline; Saïdou, Abdoul-Aziz; Bezançon, Gilles

2011-01-01

Climate changes will have an impact on food production and will require costly adaptive responses. Adapting to a changing environment will be particularly challenging in sub-Saharan Africa where climate change is expected to have a major impact. However, one important phenomenon that is often overlooked and is poorly documented is the ability of agro-systems to rapidly adapt to environmental variations. Such an adaptation could proceed by the adoption of new varieties or by the adaptation of varieties to a changing environment. In this study, we analyzed these two processes in one of the driest agro-ecosystems in Africa, the Sahel. We performed a detailed study in Niger where pearl millet is the main crop and covers 65% of the cultivated area. To assess how the agro-system is responding to recent recurrent drought, we analyzed samples of pearl millet landraces collected in the same villages in 1976 and 2003 throughout the entire cultivated area of Niger. We studied phenological and morphological differences in the 1976 and 2003 collections by comparing them over three cropping seasons in a common garden experiment. We found no major changes in the main cultivated varieties or in their genetic diversity. However, we observed a significant shift in adaptive traits. Compared to the 1976 samples, samples collected in 2003 displayed a shorter lifecycle, and a reduction in plant and spike size. We also found that an early flowering allele at the PHYC locus increased in frequency between 1976 and 2003. The increase exceeded the effect of drift and sampling, suggesting a direct effect of selection for earliness on this gene. We conclude that recurrent drought can lead to selection for earlier flowering in a major Sahelian crop. Surprisingly, these results suggest that diffusion of crop varieties is not the main driver of short term adaptation to climatic variation. PMID:21573243

Do BRCA1/2 mutation carriers have an earlier onset of natural menopause?

PubMed

van Tilborg, Theodora C; Broekmans, Frank J; Pijpe, Anouk; Schrijver, Lieske H; Mooij, Thea M; Oosterwijk, Jan C; Verhoef, Senno; Gómez Garcia, Encarna B; van Zelst-Stams, Wendy A; Adank, Muriel A; van Asperen, Christi J; van Doorn, Helena C; van Os, Theo A; Bos, Anna M; Rookus, Matti A; Ausems, Margreet G

2016-08-01

It has been hypothesized that BRCA1/2 mutation carriers have an earlier age at natural menopause (ANM), although to date findings are inconclusive. This study assessed the influence of BRCA mutation status on ANM, and aimed to explore the reasons of inconsistency in the literature. Cross-sectional assessment from an ongoing nationwide cohort study among members of BRCA1/2 mutated families. Information was obtained by a standardized questionnaire. Kaplan-Meier curves were constructed, and Cox regression was used to assess the association between BRCA1/2 mutation status and ANM. Adjustments were made for birth cohort, family, smoking, use of hormonal contraceptives, and parity. A total of 1,208 BRCA1/2 mutation carriers and 2,211 proven noncarriers were included. Overall, no association was found between BRCA1/2 mutation status and ANM (adjusted hazard ratio [HR] = 1.06 [95% CI, 0.87-1.30]). We examined if the null finding was due to informative censoring by uptake of risk-reducing salpingo-oophorectomy. Indeed, within the oldest birth cohort, in which the percentage of surgical menopause events was lowest and comparable between carriers and noncarriers, the HR for earlier natural menopause in carriers was 1.45 (95% CI, 1.09-1.94). The second oldest birth cohort, however, demonstrated a decreased HR (0.67 [95% CI, 0.46-0.98]), and thus no trend over birth cohorts was found. Various types of selection bias hamper the comparison of ANM between BRCA1/2 mutation carriers and noncarriers, genetically tested in the clinic.

Earlier parental set bedtimes as a protective factor against depression and suicidal ideation.

PubMed

Gangwisch, James E; Babiss, Lindsay A; Malaspina, Dolores; Turner, J Blake; Zammit, Gary K; Posner, Kelly

2010-01-01

To examine the relationships between parental set bedtimes, sleep duration, and depression as a quasi-experiment to explore the potentially bidirectional relationship between short sleep duration and depression. Short sleep duration has been shown to precede depression, but this could be explained as a prodromal symptom of depression. Depression in an adolescent can affect his/her chosen bedtime, but it is less likely to affect a parent's chosen set bedtime which can establish a relatively stable upper limit that can directly affect sleep duration. Multivariate cross-sectional analyses of the ADD Health using logistic regression. United States nationally representative, school-based, probability-based sample in 1994-96. Adolescents (n = 15,659) in grades 7 to 12. Adolescents with parental set bedtimes of midnight or later were 24% more likely to suffer from depression (OR = 1.24, 95% CI 1.04-1.49) and 20% more likely to have suicidal ideation (1.20, 1.01-1.41) than adolescents with parental set bedtimes of 10:00 PM or earlier, after controlling for covariates. Consistent with sleep duration and perception of getting enough sleep acting as mediators, the inclusion of these variables in the multivariate models appreciably attenuated the associations for depression (1.07, 0.88-1.30) and suicidal ideation (1.09, 0.92-1.29). The results from this study provide new evidence to strengthen the argument that short sleep duration could play a role in the etiology of depression. Earlier parental set bedtimes could therefore be protective against adolescent depression and suicidal ideation by lengthening sleep duration.

Observed Barium Emission Rates

NASA Technical Reports Server (NTRS)

Stenbaek-Nielsen, H. C.; Wescott, E. M.; Hallinan, T. J.

1993-01-01

The barium releases from the CRRES satellite have provided an opportunity for verifying theoretically calculated barium ion and neutral emission rates. Spectra of the five Caribbean releases in the summer of 1991 were taken with a spectrograph on board a U.S. Air Force jet aircraft. Because the line of sight release densities are not known, only relative rates could be obtained. The observed relative rates agree well with the theoretically calculated rates and, together with other observations, confirm the earlier detailed theoretical emission rates. The calculated emission rates can thus with good accuracy be used with photometric observations. It has been postulated that charge exchange between neutral barium and oxygen ions represents a significant source for ionization. If so. it should be associated with emissions at 4957.15 A and 5013.00 A, but these emissions were not detected.

The Classroom Observations of Vietnamese Teachers: Mediating Underlying Values to Understand Student Learning

ERIC Educational Resources Information Center

Tsukui, Atsushi; Saito, Eisuke; Sato, Masaaki; Michiyama, Megumi; Murase, Masatsugu

2017-01-01

This study uses the grounded theory approach (GTA) to investigate the value and characteristics of teacher observations, when used to understand student learning. Earlier studies have analysed the act of observation, defining it as a combination of joint observation and interpretation activities. By contrast, this analysis of 28 primary school…

The case for earlier cochlear implantation in postlingually deaf adults.

PubMed

Dowell, Richard C

2016-01-01

This paper aimed to estimate the difference in speech perception outcomes that may occur due to timing of cochlear implantation in relation to the progression of hearing loss. Data from a large population-based sample of adults with acquired hearing loss using cochlear implants (CIs) was used to estimate the effects of duration of hearing loss, age, and pre-implant auditory skills on outcomes for a hypothetical standard patient. A total of 310 adults with acquired severe/profound bilateral hearing loss who received a CI in Melbourne, Australia between 1994 and 2006 provided the speech perception data and demographic information to derive regression equations for estimating CI outcomes. For a hypothetical CI candidate with progressive sensorineural hearing loss, the estimates of speech perception scores following cochlear implantation are significantly better if implantation occurs relatively soon after onset of severe hearing loss and before the loss of all functional auditory skills. Improved CI outcomes and quality of life benefit may be achieved for adults with progressive severe hearing loss if they are implanted earlier in the progression of the pathology.

Understanding Violence in Contemporary and Earlier Gangs: An Exploratory Application of the Theory of Reasoned Action.

ERIC Educational Resources Information Center

Evans, Judy P.; Taylor, Jerome

1995-01-01

Reviews the theory of reasoned action to demonstrate how it can be applied to understanding gang violence, and illustrates its potential applicability to a pilot sample of 30 contemporary and 18 earlier gangs living in a large metropolitan community. Results indicate this theory has been helpful in explaining higher levels of violence in…

Astrometric Observations of Comets and Asteroids and Subsequent Orbital Investigations

NASA Technical Reports Server (NTRS)

Marsden, Brian G.; McCrosky, Richard E.

1997-01-01

An earlier series of photographic observations was made with the 1.5-m reflector from 1972 to 1989. The start of the series to which this report refers occurred shortly before the conversion from photographic to CCD operation in August 1989, at which point there was a dramatic increase in the productivity of the program. This is evident gives a month-by-month summary of the observations; the earlier data refer to the measurement or remeasurement of photographic plates previously taken with the same telescope. The total number of observations made was 24,423, of which 1338 were of comets. Of the 23,085 observations of asteroids, 21,529 referred to asteroids that were unnumbered when the observations were made. Since an important emphasis of the program was to improve knowledge of the orbits to the point where asteroids can be numbered, the fact that only 4262 of the observations refer to asteroids that are still unnumbered is a measure of the program's success, with 30-35 percent of all the new numberings being habitually made solely because of the recent data from the Oak Ridge program, which even at the time of McCrosky's retirement was still the fourth largest comet-asteroid astrometric program in the world.

Number of Diverticulitis Episodes Before Resection and Factors Associated With Earlier Interventions

PubMed Central

Simianu, Vlad V.; Fichera, Alessandro; Bastawrous, Amir L.; Davidson, Giana H.; Florence, Michael G.; Thirlby, Richard C.; Flum, David R.

2016-01-01

IMPORTANCE Despite professional recommendations to delay elective colon resection for patients with uncomplicated diverticulitis, early surgery (after <3 preceding episodes) appears to be common. Several factors have been suggested to contribute to early surgery, including increasing numbers of younger patients, a lower threshold to operate laparoscopically, and growing recognition of “smoldering” (or nonrecovering) diverticulitis episodes. However, the relevance of these factors in early surgery has not been well tested, and most prior studies have focused on hospitalizations, missing outpatient events and making it difficult to assess guideline adherence in earlier interventions. OBJECTIVE To describe patterns of episodes of diverticulitis before surgery and factors associated with earlier interventions using inpatient, outpatient, and antibiotic prescription claims. DESIGN, SETTING, AND PARTICIPANTS This investigation was a nationwide retrospective cohort study from January 1, 2009, to December 31, 2012. The dates of the analysis were July 2014 to May 2015. Participants were immunocompetent adult patients (age range, 18-64 years) with incident, uncomplicated diverticulitis. EXPOSURE Elective colectomy for diverticulitis. MAIN OUTCOMES AND MEASURES Inpatient, outpatient, and antibiotic prescription claims for diverticulitis captured in the MarketScan (Truven Health Analytics) databases. RESULTS Of 87 461 immunocompetent patients having at least 1 claim for diverticulitis, 6.4% (n = 5604) underwent a resection. The final study cohort comprised 3054 nonimmunocompromised patients who underwent elective resection for uncomplicated diverticulitis, of whom 55.6% (n = 1699) were male. Before elective surgery, they had a mean (SD) of 1.0 (0.9) inpatient claims, 1.5 (1.5) outpatient claims, and 0.5 (1.2) antibiotic prescription claims related to diverticulitis. Resection occurred after fewer than 3 episodes in 94.9% (2897 of 3054) of patients if counting inpatient

Selection of children to provide care: the effect of earlier parental transfers.

PubMed

Henretta, J C; Hill, M S; Li, W; Soldo, B J; Wolf, D A

1997-05-01

We use the first wave of data from the Asset and Health Dynamics Among the Oldest Old (AHEAD) study to examine the effects of past parent-to-child financial transfers on selection of a child to provide assistance with basic personal care for unmarried parents. We estimate a fixed-effects conditional logit model and find a positive and significant association between past financial transfers and a child's current helping behavior. The coefficient of past financial transfers is in the direction hypothesized, and its magnitude is 80% as large as that of gender, a well-documented powerful predictor of parental caregiving. There appears to be substantial evidence that earlier parent-to-child financial gifts play a role in determining which child in the family will provide assistance.

Increased body mass index is associated with earlier time to loss of response to infliximab in patients with inflammatory bowel disease.

PubMed

Harper, Jason W; Sinanan, Mika N; Zisman, Timothy L

2013-09-01

Obesity is an emerging problem in the care of inflammatory bowel disease (IBD) patients and has been associated with a diminished response to adalimumab. Whether obesity influences the response to infliximab (IFX) is not known. A retrospective cohort of 124 subjects with IBD initiating IFX, naive to biologic therapy, was identified. Subjects were stratified according to their weight and body mass index (BMI). The primary outcome was the first occurrence of an IBD flare defined as dose escalation of IFX, corticosteroid use, discontinuation of IFX, hospitalization, or surgery. Multivariable logistic regression was performed considering body mass and BMI as categorical and continuous variables. Obese (BMI > 30 kg/m) patients with Crohn's disease were more likely to have an IBD flare than nonobese patients (adjusted hazard ratio [HR]: 3.03, P < 0.001); overweight (BMI > 25 kg/m) patients with ulcerative colitis trended toward a similar observation (HR: 9.68, P = 0.06). When considered as continuous variables, increasing mass and BMI were associated with earlier IBD flare in both Crohn's disease (adjusted HR: 1.06 per unit increase in BMI [P = 0.02] and 1.02 per kg increase in body mass [P = 0.02]) and ulcerative colitis (adjusted HR: 1.3 per unit increase in BMI [P = 0.01] and 1.11 per kg increase in body mass [P = 0.004]). Increased body weight is associated with an earlier time to loss of response to IFX in Crohn's disease and ulcerative colitis, a novel finding given that IFX is the only antitumor necrosis factor agent whose dosing reflects increased body weight.

Clinical Evidence for the Earlier Initiation of Insulin Therapy in Type 2 Diabetes

PubMed Central

2013-01-01

Abstract The natural history of type 2 diabetes mellitus (T2DM) is a relentless progression of β-cell failure and dysregulation of β-cell function with increasing metabolic derangement. Insulin remains the only glucose-lowering therapy that is efficacious throughout this continuum. However, the timing of introduction and the choice of insulin therapy remain contentious because of the heterogeneity of T2DM and the well-recognized behavioral and therapeutic challenges associated with this mode of therapy. Nevertheless, the early initiation of basal insulin has been shown to improve glycemic control and affect long-term outcomes in people with T2DM and is a treatment strategy supported by international guidelines as part of an individualized approach to chronic disease management. The rationale for early initiation of insulin is based on evidence demonstrating multifaceted benefits, including overcoming the glucotoxic effects of hyperglycemia, thereby facilitating “β-cell rest,” and preserving β-cell mass and function, while also improving insulin sensitivity. Independent of its effects on glycemic control, insulin possesses anti-inflammatory and antioxidant properties that may help protect against endothelial dysfunction and damage resulting in vascular disease. Insulin therapy and the achievement of good glycemic control earlier in T2DM provide long-term protection to end organs via “metabolic memory” regardless of subsequent treatments and degree of glycemic control. This is evidenced from long-term observations continuing from trials such as the United Kingdom Prospective Diabetes Study. As such, early initiation of insulin therapy may not only help to avoid the effects of prolonged glycemic burden, but may also positively alter the course of disease progression. PMID:23786228

Global CALIPSO Observations of Aerosol Changes Near Clouds

NASA Technical Reports Server (NTRS)

Varnai, Tamas; Marshak, Alexander

2011-01-01

Several recent studies have found that clouds are surrounded by a transition zone of rapidly changing aerosol optical properties and particle size. Characterizing this transition zone is important for better understanding aerosol-cloud interactions and aerosol radiative effects, and also for improving satellite retrievals of aerosol properties. This letter presents a statistical analysis of a monthlong global data set of Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) lidar observations over oceans. The results show that the transition zone is ubiquitous over all oceans and extends up to 15 km away from clouds. They also show that near-cloud enhancements in backscatter and particle size are strongest at low altitudes, slightly below the top of the nearest clouds. Also, the enhancements are similar near illuminated and shadowy cloud sides, which confirms that the asymmetry of Moderate Resolution Imaging Spectroradiometer reflectances found in an earlier study comes from 3-D radiative processes and not from differences in aerosol properties. Finally, the effects of CALIPSO aerosol detection and cloud identification uncertainties are discussed. The findings underline the importance of accounting for the transition zone to avoid potential biases in studies of satellite aerosol products, aerosol-cloud interactions, and aerosol direct radiative effects.

Earlier and greater hand pre-shaping in the elderly: a study based on kinematic analysis of reaching movements to grasp objects.

PubMed

Tamaru, Yoshiki; Naito, Yasuo; Nishikawa, Takashi

2017-11-01

Elderly people are less able to manipulate objects skilfully than young adults. Although previous studies have examined age-related deterioration of hand movements with a focus on the phase after grasping objects, the changes in the reaching phase have not been studied thus far. We aimed to examine whether changes in hand shape patterns during the reaching phase of grasping movements differ between young adults and the elderly. Ten healthy elderly adults and 10 healthy young adults were examined using the Simple Test for Evaluating Hand Functions and kinetic analysis of hand pre-shaping reach-to-grasp tasks. The results were then compared between the two groups. For kinetic analysis, we measured the time of peak tangential velocity of the wrist and the inter-fingertip distance (the distance between the tips of the thumb and index finger) at different time points. The results showed that the elderly group's performance on the Simple Test for Evaluating Hand Functions was significantly lower than that of the young adult group, irrespective of whether the dominant or non-dominant hand was used, indicating deterioration of hand movement in the elderly. The peak tangential velocity of the wrist in either hand appeared significantly earlier in the elderly group than in the young adult group. The elderly group also showed larger inter-fingertip distances with arch-like fingertip trajectories compared to the young adult group for all object sizes. To perform accurate prehension, elderly people have an earlier peak tangential velocity point than young adults. This allows for a longer adjustment time for reaching and grasping movements and for reducing errors in object prehension by opening the hand and fingers wider. Elderly individuals gradually modify their strategy based on previous successes and failures during daily living to compensate for their decline in dexterity and operational capabilities. © 2017 Japanese Psychogeriatric Society.

Double-detonation Sub-Chandrasekhar Supernovae: Synthetic Observables for Minimum Helium Shell Mass Models

NASA Astrophysics Data System (ADS)

Kromer, M.; Sim, S. A.; Fink, M.; Röpke, F. K.; Seitenzahl, I. R.; Hillebrandt, W.

2010-08-01

In the double-detonation scenario for Type Ia supernovae, it is suggested that a detonation initiates in a shell of helium-rich material accreted from a companion star by a sub-Chandrasekhar-mass white dwarf. This shell detonation drives a shock front into the carbon-oxygen white dwarf that triggers a secondary detonation in the core. The core detonation results in a complete disruption of the white dwarf. Earlier studies concluded that this scenario has difficulties in accounting for the observed properties of Type Ia supernovae since the explosion ejecta are surrounded by the products of explosive helium burning in the shell. Recently, however, it was proposed that detonations might be possible for much less massive helium shells than previously assumed (Bildsten et al.). Moreover, it was shown that even detonations of these minimum helium shell masses robustly trigger detonations of the carbon-oxygen core (Fink et al.). Therefore, it is possible that the impact of the helium layer on observables is less than previously thought. Here, we present time-dependent multi-wavelength radiative transfer calculations for models with minimum helium shell mass and derive synthetic observables for both the optical and γ-ray spectral regions. These differ strongly from those found in earlier simulations of sub-Chandrasekhar-mass explosions in which more massive helium shells were considered. Our models predict light curves that cover both the range of brightnesses and the rise and decline times of observed Type Ia supernovae. However, their colors and spectra do not match the observations. In particular, their B - V colors are generally too red. We show that this discrepancy is mainly due to the composition of the burning products of the helium shell of the Fink et al. models which contain significant amounts of titanium and chromium. Using a toy model, we also show that the burning products of the helium shell depend crucially on its initial composition. This leads us to

Earlier adolescent substance use onset predicts stronger connectivity between reward and cognitive control brain networks.

PubMed

Weissman, David G; Schriber, Roberta A; Fassbender, Catherine; Atherton, Olivia; Krafft, Cynthia; Robins, Richard W; Hastings, Paul D; Guyer, Amanda E

2015-12-01

Early adolescent onset of substance use is a robust predictor of future substance use disorders. We examined the relation between age of substance use initiation and resting state functional connectivity (RSFC) of the core reward processing (nucleus accumbens; NAcc) to cognitive control (prefrontal cortex; PFC) brain networks. Adolescents in a longitudinal study of Mexican-origin youth reported their substance use annually from ages 10 to 16 years. At age 16, 69 adolescents participated in a resting state functional magnetic resonance imaging scan. Seed-based correlational analyses were conducted using regions of interest in bilateral NAcc. The earlier that adolescents initiated substance use, the stronger the connectivity between bilateral NAcc and right dorsolateral PFC, right dorsomedial PFC, right pre-supplementary motor area, right inferior parietal lobule, and left medial temporal gyrus. The regions that demonstrated significant positive linear relationships between the number of adolescent years using substances and connectivity with NAcc are nodes in the right frontoparietal network, which is central to cognitive control. The coupling of reward and cognitive control networks may be a mechanism through which earlier onset of substance use is related to brain function over time, a trajectory that may be implicated in subsequent substance use disorders. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers.

PubMed

Cohen, Joshua D; Javed, Ammar A; Thoburn, Christopher; Wong, Fay; Tie, Jeanne; Gibbs, Peter; Schmidt, C Max; Yip-Schneider, Michele T; Allen, Peter J; Schattner, Mark; Brand, Randall E; Singhi, Aatur D; Petersen, Gloria M; Hong, Seung-Mo; Kim, Song Cheol; Falconi, Massimo; Doglioni, Claudio; Weiss, Matthew J; Ahuja, Nita; He, Jin; Makary, Martin A; Maitra, Anirban; Hanash, Samir M; Dal Molin, Marco; Wang, Yuxuan; Li, Lu; Ptak, Janine; Dobbyn, Lisa; Schaefer, Joy; Silliman, Natalie; Popoli, Maria; Goggins, Michael G; Hruban, Ralph H; Wolfgang, Christopher L; Klein, Alison P; Tomasetti, Cristian; Papadopoulos, Nickolas; Kinzler, Kenneth W; Vogelstein, Bert; Lennon, Anne Marie

2017-09-19

The earlier diagnosis of cancer is one of the keys to reducing cancer deaths in the future. Here we describe our efforts to develop a noninvasive blood test for the detection of pancreatic ductal adenocarcinoma. We combined blood tests for KRAS gene mutations with carefully thresholded protein biomarkers to determine whether the combination of these markers was superior to any single marker. The cohort tested included 221 patients with resectable pancreatic ductal adenocarcinomas and 182 control patients without known cancer. KRAS mutations were detected in the plasma of 66 patients (30%), and every mutation found in the plasma was identical to that subsequently found in the patient's primary tumor (100% concordance). The use of KRAS in conjunction with four thresholded protein biomarkers increased the sensitivity to 64%. Only one of the 182 plasma samples from the control cohort was positive for any of the DNA or protein biomarkers (99.5% specificity). This combinatorial approach may prove useful for the earlier detection of many cancer types.

Modeling and Observational Study of the Global Atmospheric Impacts of Antarctic Sea Ice Anomalies

NASA Technical Reports Server (NTRS)

Bromwich, David H.; Hines, Keith M.

2004-01-01

A combined observational and modeling study considers the linkage between Antarctic sea ice and the climate of non-local latitudes. The observational component is based upon analyses of monthly station observations and the National Centers for Environmental Prediction (NCEP)/National Center for Atmospheric Research (NCAR) Reanalysis (NNR). The modeling component consists of simulations of the NCAR Community Climate Model versions 2 (CCM2) and 3 (CCM3) and the recent Community Atmosphere Model (CAM2). A convenient mechanism for communication between the Antarctic region (particularly the Ross Sea area) and the tropics and Northern Hemisphere is examined. The first evidence of this teleconnection came from CCM2 simulations performed during an earlier NASA supported project. Annual-cycle simulations with and without Antarctic sea ice show statistically- significant responses in monsoon precipitation over central and northern China during the month of September. The changes in monsoon precipitation are physically consistent with an intensified southwest Pacific (Northern Hemisphere) subtropical high in response to all Antarctic sea ice being removed and replaced with open water at -1.9"C. The intensified high is the northernmost component of three primary anomalies. The southernmost anomaly includes the Ross Sea area, where sea ice has been removed. An earlier study by Peng and Domros had also found a link between Antarctic sea ice and the East Asian monsoon circulation. The current project has helped to understand the teleconnection.

Mars Science Laboratory relative humidity observations: Initial results.

PubMed

Harri, A-M; Genzer, M; Kemppinen, O; Gomez-Elvira, J; Haberle, R; Polkko, J; Savijärvi, H; Rennó, N; Rodriguez-Manfredi, J A; Schmidt, W; Richardson, M; Siili, T; Paton, M; Torre-Juarez, M De La; Mäkinen, T; Newman, C; Rafkin, S; Mischna, M; Merikallio, S; Haukka, H; Martin-Torres, J; Komu, M; Zorzano, M-P; Peinado, V; Vazquez, L; Urqui, R

2014-09-01

The Mars Science Laboratory (MSL) made a successful landing at Gale crater early August 2012. MSL has an environmental instrument package called the Rover Environmental Monitoring Station (REMS) as a part of its scientific payload. REMS comprises instrumentation for the observation of atmospheric pressure, temperature of the air, ground temperature, wind speed and direction, relative humidity (REMS-H), and UV measurements. We concentrate on describing the REMS-H measurement performance and initial observations during the first 100 MSL sols as well as constraining the REMS-H results by comparing them with earlier observations and modeling results. The REMS-H device is based on polymeric capacitive humidity sensors developed by Vaisala Inc., and it makes use of transducer electronics section placed in the vicinity of the three humidity sensor heads. The humidity device is mounted on the REMS boom providing ventilation with the ambient atmosphere through a filter protecting the device from airborne dust. The final relative humidity results appear to be convincing and are aligned with earlier indirect observations of the total atmospheric precipitable water content. The water mixing ratio in the atmospheric surface layer appears to vary between 30 and 75 ppm. When assuming uniform mixing, the precipitable water content of the atmosphere is ranging from a few to six precipitable micrometers. Atmospheric water mixing ratio at Gale crater varies from 30 to 140 ppmMSL relative humidity observation provides good dataHighest detected relative humidity reading during first MSL 100 sols is RH75.

Low protein content of drainage fluid is a good predictor for earlier chest tube removal after lobectomy.

PubMed

Olgac, Guven; Cosgun, Tugba; Vayvada, Mustafa; Ozdemir, Atilla; Kutlu, Cemal Asim

2014-10-01

Owing to the great absorption capability of the pleura for transudates, the protein content of draining pleural fluid may be considered as a more adequate determinant than its daily draining amount in the decision-making for earlier chest tube removal. In an a priori pilot study, we observed that the initially draining protein-rich exudate converts to a transudate quickly in most patients after lobectomies. Thus, chest tubes draining high-volume but low-protein fluids can safely be removed earlier in the absence of an air leak. This randomized study aims to investigate the validity and clinical applicability of this hypothesis as well as its influence on the timing for chest tube removal and earlier discharge after lobectomy. Seventy-two consecutive patients undergoing straightforward lobectomy were randomized into two groups. Patients with conditions affecting postoperative drainage and with persisting air leaks beyond the third postoperative day were excluded. Drains were removed if the pleural fluid to blood protein ratio (PrRPl/B) was ≤0.5, regardless of its daily draining amount in the study arm (Group S; n = 38), and patients in the control arm (Group C; n = 34) had their tubes removed if daily drainage was ≤250 ml regardless of its protein content. Patients were discharged home immediately or the following morning after removal of the last drain. All cases were followed up regarding the development of symptomatic pleural effusions and hospital readmissions for a redrainage procedure. Demographic and clinical characteristics as well as the pattern of decrease in PrRPl/B were the same between groups. The mean PrRPl/B was 0.65 and 0.67 (95% CI = 0.60-0.69 and 0.62-0.72) on the first postoperative day, and it remarkably dropped down to 0.39 and 0.33 (95% CI = 0.33-0.45 and 0.27-0.39) on the second day in Groups S and C, respectively, and remained below 0.5 on the third day (repeated-measures of ANOVA design, post hoc 'within-group' comparison of the first

Uranus’ cloud structure and seasonal variability from Gemini-North and UKIRT observations

NASA Astrophysics Data System (ADS)

Irwin, P. G. J.; Teanby, N. A.; Davis, G. R.; Fletcher, L. N.; Orton, G. S.; Tice, D.; Kyffin, A.

2011-03-01

Observations of Uranus were made in September 2009 with the Gemini-North telescope in Hawaii, using both the NIFS and NIRI instruments. Observations were acquired in Adaptive Optics mode and have a spatial resolution of approximately 0.1″. NIRI images were recorded with three spectral filters to constrain the overall appearance of the planet: J, H-continuum and CH4(long), and long slit spectroscopy measurements were also made (1.49-1.79 μm) with the entrance slit aligned on Uranus’ central meridian. To acquire spectra from other points on the planet, the NIFS instrument was used and its 3″ × 3″ field of view stepped across Uranus’ disc. These observations were combined to yield complete images of Uranus at 2040 wavelengths between 1.476 and 1.803 μm. The observed spectra along Uranus central meridian were analysed with the NEMESIS retrieval tool and used to infer the vertical/latitudinal variation in cloud optical depth. We find that the 2009 Gemini data perfectly complement our observations/conclusions from UKIRT/UIST observations made in 2006-2008 and show that the north polar zone at 45°N has continued to steadily brighten while that at 45°S has continued to fade. The improved spatial resolution of the Gemini observations compared with the non-AO UKIRT/UIST data removes some of the earlier ambiguities with our previous analyses and shows that the opacity of clouds deeper than the 2-bar level does indeed diminish towards the poles and also reveals a darkening of the deeper cloud deck near the equator, perhaps coinciding with a region of subduction. We find that the clouds at 45°N,S lie at slightly lower pressures than the clouds at more equatorial latitudes, which suggests that they might possibly be composed of a different condensate, presumably CH4 ice, rather than H2S or NH3 ice, which is assumed for the deeper cloud. In addition, analysis of the centre-to-limb curves of both the Gemini/NIFS and earlier UKIRT/UIST IFU observations shows that

Phenological observations since the Linnean time in Finland

NASA Astrophysics Data System (ADS)

Kubin, E.; Poikolainen, J.; Karhu, J.; Terhivuo, J.

2012-04-01

The Finnish National Phenological Network was established in 1996 by the Finnish Forest Research Institute in collaboration with other research institutes and universities. The Network investigates the timing of phenological phases of forest plants in relation to climate factors, develops real time information to the internet and studies digital techniques as tools for monitoring. Monitoring is done troughout the growth period, focusing on nine forest tree species and two dwarf shrubs. The results can be followed in real time at: http://www.metla.fi/metinfo/fenologia/index-en.htm. The results indicate that spring phenophases usually advanced with respect to climatic conditions, but there were also differences between the years. The research period started in 1995 is relatively short and the results indicates that long-term monitoring is needed in order to detect true trends in the impacts of climate on plant phenology. The Finnish National Phenological Network has therefore collaborated with the Finnish Museum of Natural History and analysed historical phenological data based on voluntary monitoring. The oldest phenological observation series based on voluntary observers started in Finland in 1752. The long-term data shows an advancement in the timing of bud burst by five days per 100 years in Prunus padus. The onset of flowering in the rowan (Sorbus aucuparia) has become correspondingly earlier in Finland at the rate of three days per century. In the conference the focus is on a historical long-term dataset as well as on the newer Finnish National Phenological Network established for monitoring annual phenological events taking place in the same individual plants. The latest results of the network will be updated with the earlier presented historical data. Phenological monitoring is nowadays more important than ever especially in boreal regions, where spring temperatures are elevated. Compilation and documentation of observations on plant phenophases play a key

Comparison of Forecast and Observed Energetics

NASA Technical Reports Server (NTRS)

Baker, W. E.; Brin, Y.

1984-01-01

An energetics analysis scheme was developed to compare the observed kinetic energy balance over North America with that derived from forecast fields of the GLAS fourth order model for the 13 to 15 January 1979 cyclone case. It is found that: (1) the observed and predicted kinetic energy and eddy conversion are in good qualitative agreement, although the model eddy conversion tends to be 2 to 3 times stronger than the observed values. The eddy conversion which is stronger in the 12 h forecast than in observations and may be due to several factors is studied; (2) vertical profiles of kinetic energy generation and dissipation exhibit lower and upper tropospheric maxima in both the forecast and observations; (3) a lag in the observational analysis with the maximum in the observed kinetic energy occurring at 0000 GMT 14 January over the same region as the maximum ddy conversion 12 h earlier is noted.

Young and Older Observers Show Similar Perceived Contrast Functions for Isoluminat Stimuli

DTIC Science & Technology

1991-01-01

male subjects each. The young subjects were screened on the basis of admitted good general and ocular health . Subjects within the older aged group were...with the method of contrast estimation. Ten young and 10 older males (mean ages 20 and 64.5 yrs) viewed counterphase flickered gratings of 0.6 and...of the LGN, and if a selective attenuation of magno responses occurs with age , perceived contrast functions of young and older observers should

Comparison of North and South American biomes from AVHRR observations

NASA Technical Reports Server (NTRS)

Goward, Samuel N.; Dye, Dennis; Kerber, Arlene; Kalb, Virginia

1987-01-01

Previous analysis of the North American continent with AVHRR-derived vegetation index measurements showed a strong relation between known patterns of vegetation seasonality, productivity and the spectral vegetation index measurements. This study extends that analysis to South America to evaluate the degree to which these findings extend to tropical regions. The results show that the spectral vegetation index measurements provide a general indicator of vegetation activity across the major biomes of the Western Hemisphere of the earth, including tropical regions. The satellite-observed patterns are strongly related to the known climatology of the continents and may offer a means to improve understanding of global bioclimatology. For example, South America is shown to have a longer growing season with much earlier spring green-up than North America. The time integral of the measurements, computed from 12 composited monthly values, produces a value that is related to published net primary productivity data. However, limited net primary production data does not allow complete evaluation of satellite-observed contrasts between North and South American biomes. These results suggest that satellite-derived spectral vegetation index measurements are of great potential value in improving knowledge of the earth's biosphere.

Spatial Heterodyne Observations of Water (SHOW) vapour in the upper troposphere and lower stratosphere from a high altitude aircraft: Modelling and sensitivity analysis

NASA Astrophysics Data System (ADS)

Langille, J. A.; Letros, D.; Zawada, D.; Bourassa, A.; Degenstein, D.; Solheim, B.

2018-04-01

A spatial heterodyne spectrometer (SHS) has been developed to measure the vertical distribution of water vapour in the upper troposphere and the lower stratosphere with a high vertical resolution (∼500 m). The Spatial Heterodyne Observations of Water (SHOW) instrument combines an imaging system with a monolithic field-widened SHS to observe limb scattered sunlight in a vibrational band of water (1363 nm-1366 nm). The instrument has been optimized for observations from NASA's ER-2 aircraft as a proof-of-concept for a future low earth orbit satellite deployment. A robust model has been developed to simulate SHOW ER-2 limb measurements and retrievals. This paper presents the simulation of the SHOW ER-2 limb measurements along a hypothetical flight track and examines the sensitivity of the measurement and retrieval approach. Water vapour fields from an Environment and Climate Change Canada forecast model are used to represent realistic spatial variability along the flight path. High spectral resolution limb scattered radiances are simulated using the SASKTRAN radiative transfer model. It is shown that the SHOW instrument onboard the ER-2 is capable of resolving the water vapour variability in the UTLS from approximately 12 km - 18 km with ±1 ppm accuracy. Vertical resolutions between 500 m and 1 km are feasible. The along track sampling capability of the instrument is also discussed.

Kepler Observations of V447 Lyr: an Eclipsing U Gem Cataclysmic Variable

NASA Technical Reports Server (NTRS)

Ramsay, Gavin; Cannizzo, John K.; Howell, Steve B.; Wood, Matt A.; Still, Martin; Barclay, Thomas; Smale, Alan

2012-01-01

We present the results of an analysis of Kepler data covering 1.5 yr of the dwarf nova V447 Lyr. We detect eclipses of the accretion disc by the mass donating secondary star every 3.74 h which is the binary orbital period. V447 Lyr is therefore the first dwarf nova in the Kepler field to show eclipses.We also detect five long outbursts and six short outbursts showing V447 Lyr is a U Gem-type dwarf nova. We show that the orbital phase of the mid-eclipse occurs earlier during outbursts compared to quiescence and that the width of the eclipse is greater during outburst. This suggests that the bright spot is more prominent during quiescence and that the disc is larger during outburst than quiescence. This is consistent with an expansion of the outer disc radius due to the presence of high viscosity material associated with the outburst, followed by a contraction in quiescence due to the accretion of low angular momentum material. We note that the long outbursts appear to be triggered by a short outburst, which is also observed in the super-outbursts of SU UMa dwarf novae as observed using Kepler.

A Hepatocellular Carcinoma Case in a Patient Who had Immunity to Hepatitis B Virus Earlier.

PubMed

Ates, Ihsan; Kaplan, Mustafa; Demirci, Selim; Altiparmak, Emin

2016-01-01

Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver. Hepatitis B virus infection is one of the most important etilogical factors of HCC. In this case report, a patient with HCC previously infected and having ongoing immunity against hepatitis B virus will be discussed. Ates I, Kaplan M, Demirci S, Altiparmak E. A Hepatocellular Carcinoma Case in a Patient Who had Immunity to Hepatitis B Virus Earlier. Euroasian J Hepato-Gastroenterol 2016;6(1):82-83.

The 1997 Spring Regression of the Martian South Polar Cap: Mars Orbiter Camera Observations

USGS Publications Warehouse

James, P.B.; Cantor, B.A.; Malin, M.C.; Edgett, K.; Carr, M.H.; Danielson, G.E.; Ingersoll, A.P.; Davies, M.E.; Hartmann, W.K.; McEwen, A.S.; Soderblom, L.A.; Thomas, P.C.; Veverka, J.

2000-01-01

The Mars Orbiter cameras (MOC) on Mars Global Surveyor observed the south polar cap of Mars during its spring recession in 1997. The images acquired by the wide angle cameras reveal a pattern of recession that is qualitatively similar to that observed by Viking in 1977 but that does differ in at least two respects. The 1977 recession in the 0o to 120o longitude sector was accelerated relative to the 1997 observations after LS = 240o; the Mountains of Mitchel also detached from the main cap earlier in 1997. Comparison of the MOC images with Mars Orbiter Laser Altimeter data shows that the Mountains of Mitchel feature is controlled by local topography. Relatively dark, low albedo regions well within the boundaries of the seasonal cap were observed to have red-to-violet ratios that characterize them as frost units rather than unfrosted or partially frosted ground; this suggests the possibility of regions covered by CO2 frost having different grain sizes.

Quantifying the economic value and quality of life impact of earlier influenza vaccination.

PubMed

Lee, Bruce Y; Bartsch, Sarah M; Brown, Shawn T; Cooley, Philip; Wheaton, William D; Zimmerman, Richard K

2015-03-01

Influenza vaccination is administered throughout the influenza disease season, even as late as March. Given such timing, what is the value of vaccinating the population earlier than currently being practiced? We used real data on when individuals were vaccinated in Allegheny County, Pennsylvania, and the following 2 models to determine the value of vaccinating individuals earlier (by the end of September, October, and November): Framework for Reconstructing Epidemiological Dynamics (FRED), an agent-based model (ABM), and FluEcon, our influenza economic model that translates cases from the ABM to outcomes and costs [health care and lost productivity costs and quality-adjusted life-years (QALYs)]. We varied the reproductive number (R0) from 1.2 to 1.6. Applying the current timing of vaccinations averted 223,761 influenza cases, $16.3 million in direct health care costs, $50.0 million in productivity losses, and 804 in QALYs, compared with no vaccination (February peak, R0 1.2). When the population does not have preexisting immunity and the influenza season peaks in February (R0 1.2-1.6), moving individuals who currently received the vaccine after September to the end of September could avert an additional 9634-17,794 influenza cases, $0.6-$1.4 million in direct costs, $2.1-$4.0 million in productivity losses, and 35-64 QALYs. Moving the vaccination of just children to September (R0 1.2-1.6) averted 11,366-1660 influenza cases, $0.6-$0.03 million in direct costs, $2.3-$0.2 million in productivity losses, and 42-8 QALYs. Moving the season peak to December increased these benefits, whereas increasing preexisting immunity reduced these benefits. Even though many people are vaccinated well after September/October, they likely are still vaccinated early enough to provide substantial cost-savings.

Earlier onset of motor deficits in mice with double mutations in Dyt1 and Sgce.

PubMed

Yokoi, Fumiaki; Yang, Guang; Li, Jindong; DeAndrade, Mark P; Zhou, Tong; Li, Yuqing

2010-10-01

DYT1 early-onset generalized torsion dystonia is an inherited movement disorder caused by mutations in DYT1 coding for torsinA with ∼30% penetrance. Most of the DYT1 dystonia patients exhibit symptoms during childhood and adolescence. On the other hand, DYT1 mutation carriers without symptoms during these periods mostly do not exhibit symptoms later in their life. Little is known about what controls the timing of the onset, a critical issue for DYT1 mutation carriers. DYT11 myoclonus-dystonia is caused by mutations in SGCE coding for ε-sarcoglycan. Two dystonia patients from a single family with double mutations in DYT1 and SGCE exhibited more severe symptoms. A recent study suggested that torsinA contributes to the quality control of ε-sarcoglycan. Here, we derived mice carrying mutations in both Dyt1 and Sgce and found that these double mutant mice showed earlier onset of motor deficits in beam-walking test. A novel monoclonal antibody against mouse ε-sarcoglycan was developed by using Sgce knock-out mice to avoid the immune tolerance. Western blot analysis suggested that functional deficits of torsinA and ε-sarcoglycan may independently cause motor deficits. Examining additional mutations in other dystonia genes may be beneficial to predict the onset in DYT1 mutation carriers.

Variations in Maternal 5-HTTLPR Affect Observed Sensitive Parenting

ERIC Educational Resources Information Center

Cents, Rolieke A. M.; Kok, Rianne; Tiemeier, Henning; Lucassen, Nicole; Székely, Eszter; Bakermans-Kranenburg, Marian J.; Hofman, Albert; Jaddoe, Vincent W. V.; IJzendoorn, Marinus H.; Verhulst, Frank C.; Lambregtse-van den Berg, Mijke P.

2014-01-01

Background: Little is known about the genetic determinants of sensitive parenting. Two earlier studies examined the effect of the serotonin transporter polymorphism (5-HTTLPR) on sensitive parenting, but reported opposite results. In a large cohort we further examined whether 5-HTTLPR is a predictor of observed maternal sensitivity and whether…

Earlier disability of the patients followed in Multiple Sclerosis centers compared to outpatients.

PubMed

Debouverie, M; Laforest, L; Van Ganse, E; Guillemin, F

2009-02-01

The currently published works regarding the multiple sclerosis (MS) natural history report data were collected most often on population of patients recruited in MS centers. The aim was to compare the natural history of a population of patients followed in a MS centre (MSC) with patients followed outside a MS centre (NMSC). Cases were identified through the LORSEP cohort, a network of neurologists (private ambulatory practice, hospitals, and MS centers) in France. A total of 3602 patients had been analyzed: 1036 MSC patients and 2566 NMSC patients. No difference was observed regarding gender and initial symptoms. Conversely, MSC patients were younger at MS onset and were more likely to have a primary progressive initial form. Median times (years) to the EDSS scores of 3, 4, and 6 were 5.8 (5.0-6.8), 8.4 (7.9-9.0), 16.0 (14.8-18.1) in the MSC group, respectively, whereas corresponding times were 8.4 (7.9-9.0), 12.3 (11.4-13.4), 19.1 (18.0-20.2) in the NMSC group. These differences according to the type of MS supervision were statistically significant for EDSS3 (P < 0.0001), EDSS4 (P < 0.0001), and EDSS6 (P = 0.01), respectively. These findings were confirmed in Cox multivariate models. The patients followed in a MS centre had earlier disability than patients managed otherwise. Analyses exclusively conducted in patients with MS supervised in specialized centers may falsely misestimate the times needed to reach major disability landmarks. Before using registries to study the natural history of MS, efforts should be performed to verify in how far data are exhaustive and to understand the local health care system.

The Earlier the Better? Taking the AP® in 10th Grade. Research Report No. 2012-10

ERIC Educational Resources Information Center

Rodriguez, Awilda; McKillip, Mary E. M.; Niu, Sunny X.

2013-01-01

In this report, the authors examine the impact of scoring a 1 or 2 on an AP® Exam in 10th grade on later AP Exam participation and performance. As access to AP courses increases within and across schools, a growing number of students are taking AP courses and exams in the earlier grades of high school. Using a matched sample of AP and no-AP…

Collaborative observations of HDE 332077

NASA Technical Reports Server (NTRS)

Ake, Thomas B., III

1995-01-01

IUE low dispersion observations were made of the T(sub c)-deficient peculiar red giant (PRG) star, HDE 332077, to test the hypothesis that T(sub c)-poor PRG's are formed as a result of mass transfer from a binary companion rather than from internal thermal pulsing while on the asymptotic red giant branch. Previous ground-based observations of this star indicated that it is a binary, but the secondary star was too massive for an expected white dwarf. A deep, short wavelength prime (SWP) exposure was needed to search for evidence of an A-type main-sequence companion. We obtained a 120 minute LWP exposure (LWP 23479), followed by a collaborative 1230 minute SWP exposure (SWP 45113). These observations were combined with our earlier IUE and optical data on this PRG star to model the spectral energy distribution of the system.

Laser observations of the moon - Normal points for 1972

NASA Technical Reports Server (NTRS)

Shelus, P. J.; Mulholland, J. D.; Silverberg, E. C.

1975-01-01

The lunar laser observations taken at the McDonald Observatory during 1972 are presented in the form of compressed normal points, using the technique of an earlier paper. Refinements in the knowledge of the lunar motion have permitted corresponding increases in the ability to discriminate observations contaminated by equipment malfunctions; a list of amendments is given for the 1969-1971 data. The geometry of the telescope must be taken into account in the application of these data.

Observational constraints on the inter-binary stellar flare hypothesis for the gamma-ray bursts

NASA Astrophysics Data System (ADS)

Rao, A. R.; Vahia, M. N.

1994-01-01

The Gamma Ray Observatory/Burst and Transient Source Experiment (GRO/BATSE) results on the Gamma Ray Bursts (GRBs) have given an internally consistent set of observations of about 260 GRBs which have been released for analysis by the BATSE team. Using this database we investigate our earlier suggestion (Vahia and Rao, 1988) that GRBs are inter-binary stellar flares from a group of objects classified as Magnetically Active Stellar Systems (MASS) which includes flare stars, RS CVn binaries and cataclysmic variables. We show that there exists an observationally consistent parameter space for the number density, scale height and flare luminosity of MASS which explains the complete log(N) - log(P) distribution of GRBs as also the observed isotropic distribution. We further use this model to predict anisotropy in the GRB distribution at intermediate luminosities. We make definite predictions under the stellar flare hypothesis that can be tested in the near future.

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

PubMed Central

Cohen, Joshua D.; Javed, Ammar A.; Thoburn, Christopher; Wong, Fay; Tie, Jeanne; Gibbs, Peter; Schmidt, C. Max; Yip-Schneider, Michele T.; Allen, Peter J.; Schattner, Mark; Brand, Randall E.; Singhi, Aatur D.; Petersen, Gloria M.; Hong, Seung-Mo; Kim, Song Cheol; Falconi, Massimo; Doglioni, Claudio; Weiss, Matthew J.; Ahuja, Nita; He, Jin; Makary, Martin A.; Maitra, Anirban; Hanash, Samir M.; Dal Molin, Marco; Wang, Yuxuan; Li, Lu; Ptak, Janine; Dobbyn, Lisa; Schaefer, Joy; Silliman, Natalie; Popoli, Maria; Goggins, Michael G.; Hruban, Ralph H.; Wolfgang, Christopher L.; Klein, Alison P.; Tomasetti, Cristian; Papadopoulos, Nickolas; Kinzler, Kenneth W.; Vogelstein, Bert; Lennon, Anne Marie

2017-01-01

The earlier diagnosis of cancer is one of the keys to reducing cancer deaths in the future. Here we describe our efforts to develop a noninvasive blood test for the detection of pancreatic ductal adenocarcinoma. We combined blood tests for KRAS gene mutations with carefully thresholded protein biomarkers to determine whether the combination of these markers was superior to any single marker. The cohort tested included 221 patients with resectable pancreatic ductal adenocarcinomas and 182 control patients without known cancer. KRAS mutations were detected in the plasma of 66 patients (30%), and every mutation found in the plasma was identical to that subsequently found in the patient’s primary tumor (100% concordance). The use of KRAS in conjunction with four thresholded protein biomarkers increased the sensitivity to 64%. Only one of the 182 plasma samples from the control cohort was positive for any of the DNA or protein biomarkers (99.5% specificity). This combinatorial approach may prove useful for the earlier detection of many cancer types. PMID:28874546

Mars Science Laboratory relative humidity observations: Initial results

PubMed Central

Harri, A-M; Genzer, M; Kemppinen, O; Gomez-Elvira, J; Haberle, R; Polkko, J; Savijärvi, H; Rennó, N; Rodriguez-Manfredi, JA; Schmidt, W; Richardson, M; Siili, T; Paton, M; Torre-Juarez, M De La; Mäkinen, T; Newman, C; Rafkin, S; Mischna, M; Merikallio, S; Haukka, H; Martin-Torres, J; Komu, M; Zorzano, M-P; Peinado, V; Vazquez, L; Urqui, R

2014-01-01

The Mars Science Laboratory (MSL) made a successful landing at Gale crater early August 2012. MSL has an environmental instrument package called the Rover Environmental Monitoring Station (REMS) as a part of its scientific payload. REMS comprises instrumentation for the observation of atmospheric pressure, temperature of the air, ground temperature, wind speed and direction, relative humidity (REMS-H), and UV measurements. We concentrate on describing the REMS-H measurement performance and initial observations during the first 100 MSL sols as well as constraining the REMS-H results by comparing them with earlier observations and modeling results. The REMS-H device is based on polymeric capacitive humidity sensors developed by Vaisala Inc., and it makes use of transducer electronics section placed in the vicinity of the three humidity sensor heads. The humidity device is mounted on the REMS boom providing ventilation with the ambient atmosphere through a filter protecting the device from airborne dust. The final relative humidity results appear to be convincing and are aligned with earlier indirect observations of the total atmospheric precipitable water content. The water mixing ratio in the atmospheric surface layer appears to vary between 30 and 75 ppm. When assuming uniform mixing, the precipitable water content of the atmosphere is ranging from a few to six precipitable micrometers. Key Points Atmospheric water mixing ratio at Gale crater varies from 30 to 140 ppm MSL relative humidity observation provides good data Highest detected relative humidity reading during first MSL 100 sols is RH75% PMID:26213667

Earth Observations

NASA Image and Video Library

2010-06-16

ISS024-E-006136 (16 June 2010) --- Polar mesospheric clouds, illuminated by an orbital sunrise, are featured in this image photographed by an Expedition 24 crew member on the International Space Station. Polar mesospheric, or noctilucent (?night shining?), clouds are observed from both Earth?s surface and in orbit by crew members aboard the space station. They are called night-shining clouds as they are usually seen at twilight. Following the setting of the sun below the horizon and darkening of Earth?s surface, these high clouds are still briefly illuminated by sunlight. Occasionally the ISS orbital track becomes nearly parallel to Earth?s day/night terminator for a time, allowing polar mesospheric clouds to be visible to the crew at times other than the usual twilight due to the space station altitude. This unusual photograph shows polar mesospheric clouds illuminated by the rising, rather than setting, sun at center right. Low clouds on the horizon appear yellow and orange, while higher clouds and aerosols are illuminated a brilliant white. Polar mesospheric clouds appear as light blue ribbons extending across the top of the image. These clouds typically occur at high latitudes of both the Northern and Southern Hemispheres, and at fairly high altitudes of 76?85 kilometers (near the boundary between the mesosphere and thermosphere atmospheric layers). The ISS was located over the Greek island of Kos in the Aegean Sea (near the southwestern coastline of Turkey) when the image was taken at approximately midnight local time. The orbital complex was tracking northeastward, nearly parallel to the terminator, making it possible to observe an apparent ?sunrise? located almost due north. A similar unusual alignment of the ISS orbit track, terminator position, and seasonal position of Earth?s orbit around the sun allowed for striking imagery of polar mesospheric clouds over the Southern Hemisphere earlier this year.

Plasma observations of the active mother-daughter payload MAIMIK in the lower thermosphere

NASA Astrophysics Data System (ADS)

Friedrich, M.; Torkar, K. M.; Troim, J.; Maehlum, B. N.

1991-03-01

Observations during the re-entry into the denser atmosphere of a mother-daughter payload equipped with a powerful electron gun are reported. The behavior of the payload potential, the flux of returning electrons and the propagation of an HF signal differed drastically at heights below approx. 130 km from what was observed in the F-region; in particular, the payload potential remained well below the accelerator voltage. A 10 MHz signal transmitted between daughter and mother showed variations both in phase and amplitude, whereas no such signatures were seen earlier in the flight when the two bodies were closer to each other. The most likely explanation is based on an increase in plasma density near the payloads in denser regions of the atmosphere. The dynamics of the effects are discussed in terms of ion plasma waves, although no firm conclusions can be drawn.

The Asian Tropopause Aerosol Layer: Balloon-Borne Measurements, Satellite Observations and Modeling Approaches

NASA Technical Reports Server (NTRS)

Fairlie, T. D.; Vernier, J.-P.; Natarajan, M.; Deshler, Terry; Liu, H.; Wegner, T.; Baker, N.; Gadhavi, H.; Jayaraman, A.; Pandit, A.;

Microinjections observed by MMS FEEPS in the dusk to midnight region

DOE PAGES

Fennell, Joseph F.; Turner, D. L.; Lemon, C. L.; ...

2016-06-13

Energetic electron injections are commonly observed in the premidnight to dawn regions in association with substorms. However, successive electron injections are generally separated in time by hours and are rarer in the dusk region of the inner magnetosphere. Early MMS energetic electron data taken in the dusk to premidnight regions above ~9 RE show many clusters of electron injections. These injections of 50–400 keV electrons have energy dispersion signatures indicating that they gradient and curvature drifted from earlier local times. We focus on burst rate data starting near 21:00 UT on 6 August 2015. A cluster of ~40 electron injectionsmore » occurred in the following 4 h interval. The highest-resolution data showed that the electrons in the injections were trapped and had bidirectional field-aligned angular distributions. Here, these injection clusters are a new phenomenon in this region of the magnetosphere.« less

Microinjections observed by MMS FEEPS in the dusk to midnight region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fennell, Joseph F.; Turner, D. L.; Lemon, C. L.

Energetic electron injections are commonly observed in the premidnight to dawn regions in association with substorms. However, successive electron injections are generally separated in time by hours and are rarer in the dusk region of the inner magnetosphere. Early MMS energetic electron data taken in the dusk to premidnight regions above ~9 RE show many clusters of electron injections. These injections of 50–400 keV electrons have energy dispersion signatures indicating that they gradient and curvature drifted from earlier local times. We focus on burst rate data starting near 21:00 UT on 6 August 2015. A cluster of ~40 electron injectionsmore » occurred in the following 4 h interval. The highest-resolution data showed that the electrons in the injections were trapped and had bidirectional field-aligned angular distributions. Here, these injection clusters are a new phenomenon in this region of the magnetosphere.« less

A Hepatocellular Carcinoma Case in a Patient Who had Immunity to Hepatitis B Virus Earlier

PubMed Central

Kaplan, Mustafa; Demirci, Selim; Altiparmak, Emin

2016-01-01

ABSTRACT Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver. Hepatitis B virus infection is one of the most important etilogical factors of HCC. In this case report, a patient with HCC previously infected and having ongoing immunity against hepatitis B virus will be discussed. How to cite this article Ates I, Kaplan M, Demirci S, Altiparmak E. A Hepatocellular Carcinoma Case in a Patient Who had Immunity to Hepatitis B Virus Earlier. Euroasian J Hepato-Gastroenterol 2016;6(1):82-83. PMID:29201732

Preliminary Flight Deck Observations During Flight in High Ice Water Content Conditions

NASA Technical Reports Server (NTRS)

Ratvasky, Thomas; Duchanoy, Dominque; Bourdinot, Jean-Francois; Harrah, Steven; Strapp, Walter; Schwarzenboeck, Alfons; Dezitter, Fabien; Grandin, Alice

2015-01-01

In 2006, Mason et al. identified common observations that occurred in engine power-loss events attributed to flight in high concentrations of ice crystals. Observations included light to moderate turbulence, precipitation on the windscreen (often reported as rain), aircraft total temperature anomalies, lack of significant airframe icing, and no flight radar echoes at the location and altitude of the engine event. Since 2006, Mason et al. and others have collected information from pilots who experienced engine power-loss events via interviews and questionnaires to substantiate earlier observations and support event analyses. In 2011, Mason and Grzych reported that vertical acceleration data showed increases in turbulence prior to engine events, although the turbulence was usually light to moderate and not unique to high ice water content (HIWC) clouds. Mason concluded that the observation of rain on the windscreen was due to melting of ice high concentrations of ice crystals on the windscreen, coalescing into drops. Mason also reported that these pilot observations of rain on the windscreen were varied. Many pilots indicated no rain was observed, while others observed moderate rain with unique impact sounds. Mason concluded that the variation in the reports may be due to variation in the ice concentration, particle size, and temperature.

Conversion from mutual helicity to self-helicity observed with IRIS

NASA Astrophysics Data System (ADS)

Li, L. P.; Peter, H.; Chen, F.; Zhang, J.

2014-10-01

Context. In the upper atmosphere of the Sun observations show convincing evidence for crossing and twisted structures, which are interpreted as mutual helicity and self-helicity. Aims: We use observations with the new Interface Region Imaging Spectrograph (IRIS) to show the conversion of mutual helicity into self-helicity in coronal structures on the Sun. Methods: Using far UV spectra and slit-jaw images from IRIS and coronal images and magnetograms from SDO, we investigated the evolution of two crossing loops in an active region, in particular, the properties of the Si IV line profile in cool loops. Results: In the early stage two cool loops cross each other and accordingly have mutual helicity. The Doppler shifts in the loops indicate that they wind around each other. As a consequence, near the crossing point of the loops (interchange) reconnection sets in, which heats the plasma. This is consistent with the observed increase of the line width and of the appearance of the loops at higher temperatures. After this interaction, the two new loops run in parallel, and in one of them shows a clear spectral tilt of the Si IV line profile. This is indicative of a helical (twisting) motion, which is the same as to say that the loop has self-helicity. Conclusions: The high spatial and spectral resolution of IRIS allowed us to see the conversion of mutual helicity to self-helicity in the (interchange) reconnection of two loops. This is observational evidence for earlier theoretical speculations. Movie associated with Fig. 1 and Appendix A are available in electronic form at http://www.aanda.org

NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer.

PubMed

Lin, Yan; Ma, Changchun; Liu, Chengkang; Wang, Zhening; Yang, Jurong; Liu, Xinmu; Shen, Zhiwei; Wu, Renhua

2016-05-17

Colorectal cancer (CRC) is a growing cause of mortality in developing countries, warranting investigation into its earlier detection for optimal disease management. A metabolomics based approach provides potential for noninvasive identification of biomarkers of colorectal carcinogenesis, as well as dissection of molecular pathways of pathophysiological conditions. Here, proton nuclear magnetic resonance spectroscopy (1HNMR) -based metabolomic approach was used to profile fecal metabolites of 68 CRC patients (stage I/II=20; stage III=25 and stage IV=23) and 32 healthy controls (HC). Pattern recognition through principal component analysis (PCA) and orthogonal partial least squares-discriminant analysis (OPLS-DA) was applied on 1H-NMR processed data for dimension reduction. OPLS-DA revealed that each stage of CRC could be clearly distinguished from HC based on their metabolomic profiles. Successive analyses identified distinct disturbances to fecal metabolites of CRC patients at various stages, compared with those in cancer free controls, including reduced levels of acetate, butyrate, propionate, glucose, glutamine, and elevated quantities of succinate, proline, alanine, dimethylglycine, valine, glutamate, leucine, isoleucine and lactate. These altered fecal metabolites potentially involved in the disruption of normal bacterial ecology, malabsorption of nutrients, increased glycolysis and glutaminolysis. Our findings revealed that the fecal metabolic profiles of healthy controls can be distinguished from CRC patients, even in the early stage (stage I/II), highlighting the potential utility of NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in CRC patients.

NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer

PubMed Central

Lin, Yan; Ma, Changchun; Liu, Chengkang; Wang, Zhening; Yang, Jurong; Liu, Xinmu; Shen, Zhiwei; Wu, Renhua

2016-01-01

Colorectal cancer (CRC) is a growing cause of mortality in developing countries, warranting investigation into its earlier detection for optimal disease management. A metabolomics based approach provides potential for noninvasive identification of biomarkers of colorectal carcinogenesis, as well as dissection of molecular pathways of pathophysiological conditions. Here, proton nuclear magnetic resonance spectroscopy (1HNMR) -based metabolomic approach was used to profile fecal metabolites of 68 CRC patients (stage I/II=20; stage III=25 and stage IV=23) and 32 healthy controls (HC). Pattern recognition through principal component analysis (PCA) and orthogonal partial least squares-discriminant analysis (OPLS-DA) was applied on 1H-NMR processed data for dimension reduction. OPLS-DA revealed that each stage of CRC could be clearly distinguished from HC based on their metabolomic profiles. Successive analyses identified distinct disturbances to fecal metabolites of CRC patients at various stages, compared with those in cancer free controls, including reduced levels of acetate, butyrate, propionate, glucose, glutamine, and elevated quantities of succinate, proline, alanine, dimethylglycine, valine, glutamate, leucine, isoleucine and lactate. These altered fecal metabolites potentially involved in the disruption of normal bacterial ecology, malabsorption of nutrients, increased glycolysis and glutaminolysis. Our findings revealed that the fecal metabolic profiles of healthy controls can be distinguished from CRC patients, even in the early stage (stage I/II), highlighting the potential utility of NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in CRC patients. PMID:27107423

Chemistry, physiology and neuropsychology of schizophrenia: towards an earlier diagnosis of schizophrenia I.

PubMed

Kornhuber, H H

1983-01-01

Data supporting the glutamate hypothesis of schizophrenia are presented. The glutamate hypothesis is linked to the dopamine hypothesis by the fact that dopamine synapses inhibit the release of glutamate in the striate and mesolimbic system. The glutamate hypothesis of schizophrenia may open a way to find better drugs for treatment. The concept of schizophrenia I is described. It consists of "negative symptoms" such as disconcentration or reduction of energy. Schizophrenia I precedes and follows schizophrenia II with "positive symptoms," e.g. hallucinations and delusions. Schizophrenia I so far cannot be diagnosed as schizophrenia unless schizophrenia II appears. Chemical, physiological or neuropsychological methods for the diagnosis of schizophrenia I would render an earlier treatment of schizophrenia possible and thus make social and occupational rehabilitation more efficient. An objective diagnosis of schizophrenia I may also elucidate the mode of genetic transmission of schizophrenia. Several neuropsychological methods distinguish schizophrenic patients as a group from normals. Some of them are based on a specific disturbance of long term concentration. The EEG also distinguishes schizophrenics from normals when analyzed during voluntary movement. For schizophrenics it takes more effort to initiate a voluntary movement, and there are several features of the EEG correlated to this. Moreover, the longer motor reaction time of schizophrenics is paralleled by a longer duration of the Bereitschaftspotential in schizophrenia. Furthermore, there is a difference in the theta rhythm between schizophrenic patients and normals in a task which requires concentration. Some of the children of schizophrenic parents show a disturbance of concentration in both reaction time tasks and the d 2 test.(ABSTRACT TRUNCATED AT 250 WORDS)

Observations of the andromeda galaxy at 11-centimeter wavelength.

PubMed

Cooley, R C; Roberts, M S; Swenson, G W

1967-05-26

Observations of the Andromeda galaxy (M31) at 2695 megahertz reveal more detail than do earlier measurements at lower frequency. The region is highly confused but there is apparently a more dense clustering of sources within the optical outline of the galaxy than without. One source (OA33) near M31 has an interesting. flat spectrum.

The cortical representation of the speech envelope is earlier for audiovisual speech than audio speech.

PubMed

Crosse, Michael J; Lalor, Edmund C

2014-04-01

Visual speech can greatly enhance a listener's comprehension of auditory speech when they are presented simultaneously. Efforts to determine the neural underpinnings of this phenomenon have been hampered by the limited temporal resolution of hemodynamic imaging and the fact that EEG and magnetoencephalographic data are usually analyzed in response to simple, discrete stimuli. Recent research has shown that neuronal activity in human auditory cortex tracks the envelope of natural speech. Here, we exploit this finding by estimating a linear forward-mapping between the speech envelope and EEG data and show that the latency at which the envelope of natural speech is represented in cortex is shortened by >10 ms when continuous audiovisual speech is presented compared with audio-only speech. In addition, we use a reverse-mapping approach to reconstruct an estimate of the speech stimulus from the EEG data and, by comparing the bimodal estimate with the sum of the unimodal estimates, find no evidence of any nonlinear additive effects in the audiovisual speech condition. These findings point to an underlying mechanism that could account for enhanced comprehension during audiovisual speech. Specifically, we hypothesize that low-level acoustic features that are temporally coherent with the preceding visual stream may be synthesized into a speech object at an earlier latency, which may provide an extended period of low-level processing before extraction of semantic information.

[Clinical view of toxoplasmosis in children--personal observations].

PubMed

Czarnecka-Rudnik, D; Stanek-Bazylko, F

1997-05-01

In this work we presented our own experience with recognized and treated toxoplasmosis among children. Treated cases were observed over several years afterwards. We analyzed the frequency and character of clinical changes, evaluated the validity of serological screening and the effectiveness of treatment. The largest age group treated were children 13 months to 5 years old. 13 children had the congenital and 12 the acquired form. The most cases occurred in the nodal, ocular and ocular-cranial forms. Thus, the most common symptoms were enlarged lymphatic nodes, strabismus, febrile seizures, intracranial calcifications. In the acquired forms of the illness a distinct correlation between treatment and the decrease antibody levels, the clinical pictures showed stagnation. The fall in antibody levels occurred earlier with intermediate immunofluorescence than with ELISA method. Among 20 children associated 30-day treatment was implemented (Daraprim, Rovamycine, Biseptol), among 4 with Fansidar and Rovamycine for 2-3 weeks. Few complications occurred at the end of or after treatment and did not require treatment/intervention. Usually it was leukopenia and thrombocytopenia. Long time observation allows to state that both therapeutic models prevent renewal of illness and can be recommended for further use.

Quantifying the Economic Value and Quality of Life Impact of Earlier Influenza Vaccination

PubMed Central

Lee, Bruce Y.; Bartsch, Sarah M.; Brown, Shawn T.; Cooley, Philip; Wheaton, William D.; Zimmerman, Richard K.

2015-01-01

Background Influenza vaccination is administered throughout the influenza disease season, even as late as March. Given such timing, what is the value of vaccinating the population earlier than currently being practiced? Methods We used real data on when individuals were vaccinated in Allegheny County, Pennsylvania, and the following 2 models to determine the value of vaccinating individuals earlier (by the end of September, October, and November): Framework for Reconstructing Epidemiological Dynamics (FRED), an agent-based model (ABM), and FluEcon, our influenza economic model that translates cases from the ABM to outcomes and costs [health care and lost productivity costs and quality-adjusted life-years (QALYs)]. We varied the reproductive number (R0) from 1.2 to 1.6. Results Applying the current timing of vaccinations averted 223,761 influenza cases, $16.3 million in direct health care costs, $50.0 million in productivity losses, and 804 in QALYs, compared with no vaccination (February peak, R0 1.2). When the population does not have preexisting immunity and the influenza season peaks in February (R0 1.2–1.6), moving individuals who currently received the vaccine after September to the end of September could avert an additional 9634–17,794 influenza cases, $0.6–$1.4 million in direct costs, $2.1–$4.0 million in productivity losses, and 35–64 QALYs. Moving the vaccination of just children to September (R0 1.2–1.6) averted 11,366–1660 influenza cases, $0.6–$0.03 million in direct costs, $2.3–$0.2 million in productivity losses, and 42–8 QALYs. Moving the season peak to December increased these benefits, whereas increasing preexisting immunity reduced these benefits. Conclusion Even though many people are vaccinated well after September/October, they likely are still vaccinated early enough to provide substantial cost-savings. PMID:25590676

Women showing off: notes on female exhibitionism.

PubMed

Balsam, Rosemary H

2008-03-01

The limitations of the phallocentric cast of earlier psychoanalytic formulations of "female exhibitionism" linger into the present. In part this connects to certain historical expectations for women's social behavior, and to the vicissitudes of Freud's insufficient knowledge of women in his libidinal psychosexual phasing used as a basis for analytic understanding. The contemporary fade of libido theory contributes to the neglect of such topics as they relate to the biological body. Yet ease and conflict regarding conscious and unconscious female body image representations related to that stepchild of theory-pregnancy and childbirth in particular-play a major role in female body display. Recognition of such body fantasies and female body meanings from early childhood into maturity tends to be marginalized within all of the psychoanalytic theories current today. The focus here on female exhibitionism suggests a normative spectrum for pleasurably active sex seeking and pleasurable procreative desire and fantasy that is present in a female's use of her body and which (of course, but secondarily) can become caught up in conflict. Two cases accenting analyses of female "showing off" behavior are included.

ASCA Observations of LMC SNRS

NASA Technical Reports Server (NTRS)

Hughes, John P.

1999-01-01

We present our first results from a study of the supernova remnants (SNRs) in the Large Magellanic Cloud (LMC) using data from ASCA. The three remnants we have analyzed to date, 0509-67.5, 0519-69.0, and N103B, are among the smallest, and presumably also the youngest, in the Cloud. The X-ray spectra of these SNRs show strong K(alpha) emission lines of silicon, sulfur, argon, and calcium with no evidence for corresponding lines of oxygen, neon, or magnesium. The dominant feature in the spectra is a broad blend of emission lines around 1 keV which we attribute to L-shell emission lines of iron. Model calculations (Nomoto, Thielemann, & Yokoi 1984) show that the major products of nucleosynthesis in Type Ia supernovae (SNs) are the elements from silicon to iron, as observed here. The calculated nucleosynthetic yields from Type Ib and II SNs are shown to be qualitatively inconsistent with the data. We conclude that the SNs which produced these remnants were of Type Ia. This finding also confirms earlier suggestions that the class of Balmer-dominated remnants arise from Type Ia SN explosions. Based an these early results from the LMC SNR sample, we find that roughly one-half of the SNRs produced in the LMC within the last approximately 1500 yr came from Type Ia SNs.

Satellite-derived SIF and CO2 Observations Show Coherent Responses to Interannual Climate Variations

NASA Astrophysics Data System (ADS)

Butterfield, Z.; Hogikyan, A.; Kulawik, S. S.; Keppel-Aleks, G.

2017-12-01

Gross primary production (GPP) is the single largest carbon flux in the Earth system, but its sensitivity to changes in climate is subject to significant uncertainty. Satellite measurements of solar-induced chlorophyll fluorescence (SIF) offer insight into spatial and temporal patterns in GPP at a global scale and, combined with other satellite-derived datasets, provide unprecedented opportunity to explore interactions between atmospheric CO2, GPP, and climate variability. To explore potential drivers of GPP in the Northern Hemisphere (NH), we compare monthly-averaged SIF data from the Global Ozone Monitoring Experiment 2 (GOME-2) with observed anomalies in temperature (T; CRU-TS), liquid water equivalent (LWE) from the Gravity Recovery and Climate Experiment (GRACE), and photosynthetically active radiation (PAR; CERES SYN1deg). Using observations from 2007 through 2015 for several NH regions, we calculate month-specific sensitivities of SIF to variability in T, LWE, and PAR. These sensitivities provide insight into the seasonal progression of how productivity is affected by climate variability and can be used to effectively model the observed SIF signal. In general, we find that high temperatures are beneficial to productivity in the spring, but detrimental in the summer. The influences of PAR and LWE are more heterogeneous between regions; for example, higher LWE in North American temperate forest leads to decreased springtime productivity, while exhibiting a contrasting effect in water-limited regions. Lastly, we assess the influence of variations in terrestrial productivity on atmospheric carbon using a new lower tropospheric CO2 product derived from the Greenhouse Gases Observing Satellite (GOSAT). Together, these data shed light on the drivers of interannual variability in the annual cycle of NH atmospheric CO2, and may provide improved constraints on projections of long-term carbon cycle responses to climate change.

Babylonian observations

NASA Astrophysics Data System (ADS)

Brown, D.

Very few cuneiform records survive from Mesopotamia of datable astronomical observations made prior to the mid-eighth century BC. Those that do record occasional eclipses, and in one isolated case the dates of the heliacal rising and setting of Venus over a few years sometime in the first half of the second millennium BC. After the mid-eighth century BC the situation changes dramatically. Incomplete records of daily observations of astronomical and meteorological events are preserved from c. 747 BC until the Christian Period. These records are without accompanying ominous interpretation, although it is highly probable that they were compiled by diviners for astrological purposes. They include numerous observations of use to historical astronomers, such as the times of eclipses and occultations, and the dates of comet appearances and meteor showers. The question arises as to why such records do not survive from earlier times; celestial divination was employed as far back as the third millenium BC. It is surely not without importance that the earliest known accurate astronomical predictions accompany the later records, and that the mid-eighth century BC ushered in a period of centralised Assyrian control of Mesopotamia and the concomitant employment by the Assyrian ruler of large numbers of professional celestial diviners. The programme of daily observations evidently began when a high premium was first set on the accurate astronomical prediction of ominous events. It is in this light that we must approach this valuable source material for historical astronomy.

Onset of rigor mortis is earlier in red muscle than in white muscle.

PubMed

Kobayashi, M; Takatori, T; Nakajima, M; Sakurada, K; Hatanaka, K; Ikegaya, H; Matsuda, Y; Iwase, H

2000-01-01

Rigor mortis is thought to be related to falling ATP levels in muscles postmortem. We measured rigor mortis as tension determined isometrically in three rat leg muscles in liquid paraffin kept at 37 degrees C or 25 degrees C--two red muscles, red gastrocnemius (RG) and soleus (SO) and one white muscle, white gastrocnemius (WG). Onset, half and full rigor mortis occurred earlier in RG and SO than in WG both at 37 degrees C and at 25 degrees C even though RG and WG were portions of the same muscle. This suggests that rigor mortis directly reflects the postmortem intramuscular ATP level, which decreases more rapidly in red muscle than in white muscle after death. Rigor mortis was more retarded at 25 degrees C than at 37 degrees C in each type of muscle.

The 2011 Draconids: The First European Airborne Meteor Observation Campaign

NASA Astrophysics Data System (ADS)

Vaubaillon, Jeremie; Koten, Pavel; Margonis, Anastasios; Toth, Juraj; Rudawska, Regina; Gritsevich, Maria; Zender, Joe; McAuliffe, Jonathan; Pautet, Pierre-Dominique; Jenniskens, Peter; Koschny, Detlef; Colas, Francois; Bouley, Sylvain; Maquet, Lucie; Leroy, Arnaud; Lecacheux, Jean; Borovicka, Jiri; Watanabe, Junichi; Oberst, Jürgen

2015-02-01

On 8 October 2011, the Draconid meteor shower (IAU, DRA) was predicted to cause two brief outbursts of meteors, visible from locations in Europe. For the first time, a European airborne meteor observation campaign was organized, supported by ground-based observations. Two aircraft were deployed from Kiruna, Sweden, carrying six scientists, 19 cameras and eight crew members. The flight geometry was chosen such that it was possible to obtain double-station observations of many meteors. The instrument setup on the aircraft as well as on the ground is described in full detail. The main peak from 1900-dust ejecta happened at the predicted time and at the predicted rate. The second peak was observed from the earlier flight and from the ground, and was caused most likely by trails ejected in the nineteenth century. A total of 250 meteors were observed, for which light curve data were derived. The trajectory, velocity, deceleration and orbit of 35 double station meteors were measured. The magnitude distribution index was high, as a result of which there was no excess of meteors near the horizon. The light curve proved to be extremely flat on average, which was unexpected. Observations of spectra allowed us to derive the compositional information of the Draconids meteoroids and showed an early release of sodium, usually interpreted as resulting from fragile meteoroids. Lessons learned from this experience are derived for future airborne meteor shower observation campaigns.

Planning steps forward in development: in girls earlier than in boys.

PubMed

Unterrainer, Josef M; Ruh, Nina; Loosli, Sandra V; Heinze, Katharina; Rahm, Benjamin; Kaller, Christoph P

2013-01-01

The development of planning ability in children initially aged four and five was examined longitudinally with a retest-interval of 12 months using the Tower of London task. As expected, problems to solve straightforward without mental look-ahead were mastered by most, even the youngest children. Problems demanding look-ahead were more difficult and accuracy improved significantly with age and over time. This development was strongly moderated by sex: In contrast to coeval boys, four year old girls showed an impressive performance enhancement at age five, reaching the performance of six year olds, whereas four year old boys lagged behind and caught up with girls at the age of six, the typical age of school enrollment. This sex-specific development of planning was clearly separated from overall intelligence: young boys showed a steeper increase in raw intelligence scores than girls, whereas in the older groups scores developed similarly. The observed sex differences in planning development are evident even within a narrow time window of twelve months and may relate to differences in maturational trajectories for girls and boys in dorsolateral prefrontal cortex.

Age of diagnosis of breast cancer in china: almost 10 years earlier than in the United States and the European union.

PubMed

Song, Qing-Kun; Li, Jing; Huang, Rong; Fan, Jin-Hu; Zheng, Rong-Shou; Zhang, Bao-Ning; Zhang, Bin; Tang, Zhong-Hua; Xie, Xiao-Ming; Yang, Hong-Jian; He, Jian-Jun; Li, Hui; Li, Jia-Yuan; Qiao, You-Lin; Chen, Wan-Qing

2014-01-01

The study aimed to describe the age distribution of breast cancer diagnosis among Chinese females for comparison with the United States and the European Union, and provide evidence for the screening target population in China. Median age was estimated from hospital databases from 7 tertiary hospitals in China. Population-based data in China, United States and European Union was extracted from the National Central Cancer Registry, SEER program and GLOBOCAN 2008, respectively. Age-standardized distribution of breast cancer at diagnosis in the 3 areas was estimated based on the World Standard Population 2000. The median age of breast cancer at diagnosis was around 50 in China, nearly 10 years earlier than United States and European Union. The diagnosis age in China did not vary between subgroups of calendar year, region and pathological characteristics. With adjustment for population structure, median age of breast cancer at diagnosis was 50~54 in China, but 55~59 in United States and European Union. The median diagnosis age of female breast cancer is much earlier in China than in the United States and the European Union pointing to racial differences in genetics and lifestyle. Screening programs should start at an earlier age for Chinese women and age disparities between Chinese and Western women warrant further studies.

Water vapour tomography using GPS phase observations: Results from the ESCOMPTE experiment

NASA Astrophysics Data System (ADS)

Nilsson, T.; Gradinarsky, L.; Elgered, G.

2007-10-01

Global Positioning System (GPS) tomography is a technique for estimating the 3-D structure of the atmospheric water vapour using data from a dense local network of GPS receivers. Several current methods utilize estimates of slant wet delays between the GPS satellites and the receivers on the ground, which are difficult to obtain with millimetre accuracy from the GPS observations. We present results of applying a new tomographic method to GPS data from the Expériance sur site pour contraindre les modèles de pollution atmosphérique et de transport d'emissions (ESCOMPTE) experiment in southern France. This method does not rely on any slant wet delay estimates, instead it uses the GPS phase observations directly. We show that the estimated wet refractivity profiles estimated by this method is on the same accuracy level or better compared to other tomographic methods. The results are in agreement with earlier simulations, for example the profile information is limited above 4 km.

Interplay Between Theory and Observation

NASA Astrophysics Data System (ADS)

Hebb Swank, Jean

2013-01-01

In the early 1970’s, after the rocket flights had identified some sources, Uhuru was surveying the sky, and neutron stars, black holes, supernova remnants, clusters of galaxies had been tentatively identified as responsible. Coming from a theoretical particle physics background, I was especially interested in the astrophysical manifestations of fundamental physics in neutron stars and black holes, and history shows the exciting interplay between theory and observation. OSO-8 provided my first example of an observation that made a clear simple identification; the cooling black body spectrum with constant radius strongly pointed to a neutron star as the source. The instrument had enough area, energy resolution and time resolution to see it. Unbeknownst to me, thermonuclear flashes of accreting material had been predicted and they had been proposed as the explanation for bursts. At the next level of detail, to accurately determine mass, to account for emissivity (the color correction) and general relativity, and use the observations to determine mass and radius, and the nuclear fuel, many other parameters play a role. RXTE was designed to answer many of the questions developed as a consequence of earlier missions. One of them was the question of whether the neutron stars in the bursts were spun up pulsars and whether the low frequency quasi-periodic pulsations (QPO) seen with EXOSAT and Ginga were interactions of the accretion disk and a pulsar. RXTE’s first observations of low mass x-ray binaries showed the kilohertz quasi-periodic oscillations and the burst oscillations. The PCA had the area and the time resolution to see them. I should have known that kilohertz QPO had also been predicted. Again, while some aspects are simple, at the next level, for both neutron stars and black holes, many other parameters and questions of interpretation must be considered. These especially affect the ability to use the sources identified as black holes to understand their

Presunrise ion temperature enhancement observed at 600 km low- and mid-latitude ionosphere

NASA Astrophysics Data System (ADS)

Chao, C. K.; Su, S.-Y.; Yeh, H. C.

2003-02-01

The quiet-time low- and mid-latitude topside ionospheric ion temperature measured with ROCSAT-1/IPEI instrument is studied for local time, longitudinal, latitudinal, and seasonal variations for the solar maximum year of 2000. The statistical result shows two significant observations at the presunrise sector. Namely, the earliest presunrise ion temperature increase at 600 km low- and mid-latitude ionosphere always starts in the winter hemisphere for both summer and winter seasons; and the strongest presunrise ion-heating region is located in the longitudinal region between 165° and 195° during June summer and between 285° and 345° during December winter. Our simple calculation indicates that the temperature increase at the satellite altitude results from the heating process of photoelectrons that are produced at the magnetic conjugate-point where sunrise is at an earlier time. However, the mechanism to enhance the photoelectron heating at the strongest presunrise ion-heating region is still not clear, because the observed ion density and the field flow data fail to lend a clear support to the proposed heating mechanism for the current observations.

Observation and simulation of the ionosphere disturbance waves triggered by rocket exhausts

NASA Astrophysics Data System (ADS)

Lin, Charles C. H.; Chen, Chia-Hung; Matsumura, Mitsuru; Lin, Jia-Ting; Kakinami, Yoshihiro

2017-08-01

Observations and theoretical modeling of the ionospheric disturbance waves generated by rocket launches are investigated. During the rocket passage, time rate change of total electron content (rTEC) enhancement with the V-shape shock wave signature is commonly observed, followed by acoustic wave disturbances and region of negative rTEC centered along the trajectory. Ten to fifteen min after the rocket passage, delayed disturbance waves appeared and propagated along direction normal to the V-shape wavefronts. These observation features appeared most prominently in the 2016 North Korea rocket launch showing a very distinct V-shape rTEC enhancement over enormous areas along the southeast flight trajectory despite that it was also appeared in the 2009 North Korea rocket launch with the eastward flight trajectory. Numerical simulations using the physical-based nonlinear and nonhydrostatic coupled model of neutral atmosphere and ionosphere reproduce promised results in qualitative agreement with the characteristics of ionospheric disturbance waves observed in the 2009 event by considering the released energy of the rocket exhaust as the disturbance source. Simulations reproduce the shock wave signature of electron density enhancement, acoustic wave disturbances, the electron density depletion due to the rocket-induced pressure bulge, and the delayed disturbance waves. The pressure bulge results in outward neutral wind flows carrying neutrals and plasma away from it and leading to electron density depletions. Simulations further show, for the first time, that the delayed disturbance waves are produced by the surface reflection of the earlier arrival acoustic wave disturbances.

H2 S3(1) and S4(1) transitions in the atmospheres of Neptune and Uranus - Observations and analysis

NASA Technical Reports Server (NTRS)

Smith, Wm. Hayden; Baines, Kevin H.

1990-01-01

The present observational results for Neptune's S3(1) and S4(1) H2 lines show the former line's measured equivalent width to be the same as for this feature in Uranus, repeating the equality already established between the two planets for the latter feature. It is also noted that the observed ratio of the H2 S3(0)/S3(1) lines for Neptune's atmosphere is reproduced by models belonging to the family of models created by Baines and Smith (1990); by comparison with the earlier Uranus models of Baines and Bergstrahl (1986), the greater continuum absorption of Neptune is responsible for the increased S3(0)/S3(1) line ratio near 0.82 microns.

Best in show but not best shape: a photographic assessment of show dog body condition.

PubMed

Such, Z R; German, A J

2015-08-01

Previous studies suggest that owners often wrongly perceive overweight dogs to be in normal condition. The body shape of dogs attending shows might influence owners' perceptions, with online images of overweight show winners having a negative effect. This was an observational in silico study of canine body condition. 14 obese-prone breeds and 14 matched non-obese-probe breeds were first selected, and one operator then used an online search engine to identify 40 images, per breed, of dogs that had appeared at a major national UK show (Crufts). After images were anonymised and coded, a second observer subjectively assessed body condition, in a single sitting, using a previously validated method. Of 1120 photographs initially identified, 960 were suitable for assessing body condition, with all unsuitable images being from longhaired breeds. None of the dogs (0 per cent) were underweight, 708 (74 per cent) were in ideal condition and 252 (26 per cent) were overweight. Pugs, basset hounds and Labrador retrievers were most likely to be overweight, while standard poodles, Rhodesian ridgebacks, Hungarian vizslas and Dobermanns were least likely to be overweight. Given the proportion of show dogs from some breeds that are overweight, breed standards should be redefined to be consistent with a dog in optimal body condition. British Veterinary Association.

Experimental observation of Fano effect in Ag nanoparticle-CdTe quantum dot hybrid system

NASA Astrophysics Data System (ADS)

Gurung, Sabina; Jayabalan, J.; Singh, Asha; Khan, Salahuddin; Chari, Rama

2018-04-01

We have experimentally measured the optical properties of Ag nanoparticle-CdTe quantum dot hybrid system and compared it with that of bare CdTe quantum dot colloid. It has been shown that the photoluminescence line shape of CdTe quantum dots becomes asymmetric in presence of Ag nanoparticles. The observed changes in the PL spectrum closely match the expected changes in the line shape due to Fano interaction between discrete level and continuum levels. Our experiment shows that a very small fraction of metal nanoparticles in the metal-semiconductor hybrid is sufficient to induce such changes in line shape which is in contrary to the earlier reported theoretical prediction on metal-semiconductor hybrid.

AN Lyn: a multiperiodic Delta Scuti star showing atypical light curves

NASA Astrophysics Data System (ADS)

Rodriguez, E.; Gonzalez-Bedolla, S. F.; Rolland, A.; Costa, V.; Lopez-Gonzalez, M. J.; Lopez de Coca, P.

1997-07-01

We have collected simultaneous uvby photometry of the Delta Sct star AN Lyn during the years 1995 and 1996 at the observatories of San Pedro Mertir, Mexico and Sierra Nevada, Spain. Firstly, analysis of frequencies of our 1995's data set was carried out using the Discrete Fourier Transform method, as described in Lopez de Coca et al. (1984), to the filter v. The periodograms showed a principal peak at v1 ~ 10.1756 c/d, very close to that frequency which corresponds to the period P ~0.0982739 d derived from earlier works. After prewhitening for v1 we found a second peak at 20.3525 c/d that corresponds to 2*v1. When these two frequencies are subtracted from the light curves, the periodograms show some peaks that reveal that additional frequencies are remaining in the spectra at very low amplitude as compared with the amplitude of the main peak (less than 5%).

Dissemination of a Web-Based Tool for Supporting Health Insurance Plan Decisions (Show Me Health Plans): Cross-Sectional Observational Study.

PubMed

Zhao, Jingsong; Mir, Nageen; Ackermann, Nicole; Kaphingst, Kimberly A; Politi, Mary C

2018-06-20

The rate of uninsured people has decreased dramatically since the Affordable Care Act was passed. To make an informed decision, consumers need assistance to understand the advantages and disadvantages of health insurance plans. The Show Me Health Plans Web-based decision support tool was developed to improve the quality of health insurance selection. In response to the promising effectiveness of Show Me Health Plans in a randomized controlled trial (RCT) and the growing need for Web-based health insurance decision support, the study team used expert recommendations for dissemination and implementation, engaged external stakeholders, and made the Show Me Health Plans tool available to the public. The purpose of this study was to implement the public dissemination of the Show Me Health Plans tool in the state of Missouri and to evaluate its impact compared to the RCT. This study used a cross-sectional observational design. Dissemination phase users were compared with users in the RCT study across the same outcome measures. Time spent using the Show Me Health Plans tool, knowledge, importance rating of 9 health insurance features, and intended plan choice match with algorithm predictions were examined. During the dissemination phase (November 2016 to January 2017), 10,180 individuals visited the SMHP website, and the 1069 users who stayed on the tool for more than one second were included in our analyses. Dissemination phase users were more likely to live outside St. Louis City or County (P<.001), were less likely to be below the federal poverty level (P<.001), and had a higher income (P=.03). Overall, Show Me Health Plans users from St. Louis City or County spent more time on the Show Me Health Plans tool than those from other Missouri counties (P=.04); this association was not observed in the RCT. Total time spent on the tool was not correlated with knowledge scores, which were associated with lower poverty levels (P=.009). The users from the RCT phase were more

Quadruple cancer including Bowen's disease after arsenic injections 40 years earlier: report of a case.

PubMed

Murata, K; Iwazawa, T; Takayama, T; Yamashita, K; Okagawa, K

1994-01-01

This report describes the successful treatment of quadruple cancer including Bowen's disease in a 71-year-old man who had been given injections of salvarsan, an arsenic compound, for syphilis more than 40 years earlier. Resection of a skin lesion on his chest subsequently confirmed a diagnosis of Bowen's disease, 3 years after which he was operated on for concurrent gastric cancer and sigmoid colon cancer. A fourth cancer was discovered on his left vocal cord 2 weeks after this operation; it was resected 2 years later. A discussion of multiple malignant neoplasms and the possible relationship between arsenic and cancer is presented following this case report.

New Observation of the Polar Wind in the Topside Ionosphere

NASA Astrophysics Data System (ADS)

Yau, Andrew W.; Howarth, Andrew

2016-07-01

The theoretical prediction of the "classical" polar wind dates back to the works of Banks et al., Lemaire et al., Marubashi, Nishida, and other authors in the late sixties and early seventies. Since then, direct in-situ observations of the polar wind have been made on a number of satellites above the topside ionosphere, notably ISIS-2, Akebono, and DE-1, at altitudes of 1400-50,000 km. In this paper, we present the first in-situ observation of the polar wind inside the topside ionosphere on the Enhanced Polar Outflow Probe (e-POP) down to 600 km, and we compare our low-altitude observation with earlier observations at higher altitudes as well as theoretical predictions.

Observation of cosmic-ray particles with Z of 50 or greater and interpretation of the charge spectrum.

NASA Technical Reports Server (NTRS)

Blanford, G. E., Jr.; Friedlander, M. W.; Klarmann, J.; Walker, R. M.; Wefel, J. P.

1973-01-01

Large areas of plastic detectors and nuclear emulsions were exposed to the primary cosmic radiation on two high-altitude balloon flights in May 1968 and September 1969. From measurements on the tracks found in the scanning of the plastic detectors, events with charges Z greater than 50 were selected, and these data were consolidated with those from our earlier flights. Several conclusions can be drawn from the observed charge spectrum. The detection of trans-bismuth nuclei confirms earlier observations of these particles in the cosmic rays. However, no trans-uranium particles were observed. Detailed features of the charge spectrum cannot be explained by nuclei from r-process nucleosynthesis alone. Although the addition of particles following s-process abundances yields improved agreement, the spectrum appears more complicated than would result from a simple combination of r- and s-process abundances with identical propagation histories.

Rosat sky survey observations of the eclipsing binary V471 Tauri

NASA Technical Reports Server (NTRS)

Barstow, M. A.; Schmitt, J. H. M. M.; Clemens, J. C.; Pye, J. P.; Denby, M.; Harris, A. W.; Pankiewicz, G. S.

1992-01-01

Rosat observations of the DA white dwarf + K2V binary system V471 Tauri, obtained during the sky survey phase of the mission, are presented. A lower amplitude shorter time-scale variability is seen in both the soft X-ray and EUV bands. This is associated with the white dwarf pulsations previously discovered by Exosat and also observed at optical wavelengths. The minimum in the EUV light curve is found to coincide with the maximum in the optical. This direct comparison of the phases of the optical and EUV pulses confirms the prediction made by an earlier indirect comparison and shows conclusively that the V471 Tau oscillations cannot arise from nonradial g-mode pulsations in the white dwarf. They are argued to be caused by rotation of the white dwarf with accretion-darkened magnetic poles. On the basis of the EUV and optical pulse shapes, the accretion geometry is studied, and it is estimated that the rate of accretion onto the white dwarf is about (4-11) x 10 exp -13 solar mass/yr.

Jet-cooled laser-induced dispersed fluorescence spectroscopy of TaN: Observation of a3Δ and A1Δ states

NASA Astrophysics Data System (ADS)

Mukund, Sheo; Bhattacharyya, Soumen; Nakhate, S. G.

2016-07-01

Laser-induced dispersed fluorescence spectra of TaN molecules, produced in a free-jet apparatus, have been studied. Two spin components of the lowest-lying a3Δ state along with their vibrational structure have been observed. The A1Δ state, which was predicted earlier by ab initio calculation has also been observed. The X1Σ+ ground state vibrational progression up to v = 9 has been recorded. The experimentally determined term energies and vibrational constants at equilibrium for the ground and a3Δ states are in fairly good agreement with the ab initio values reported earlier.

Effects of earlier sea ice breakup on survival and population size of polar bears in western Hudson Bay

USGS Publications Warehouse

Regehr, E.V.; Lunn, N.J.; Amstrup, Steven C.; Stirling, I.

2007-01-01

Some of the most pronounced ecological responses to climatic warming are expected to occur in polar marine regions, where temperature increases have been the greatest and sea ice provides a sensitive mechanism by which climatic conditions affect sympagic (i.e., with ice) species. Population-level effects of climatic change, however, remain difficult to quantify. We used a flexible extension of Cormack-Jolly-Seber capture-recapture models to estimate population size and survival for polar bears (Ursus maritimus), one of the most ice-dependent of Arctic marine mammals. We analyzed data for polar bears captured from 1984 to 2004 along the western coast of Hudson Bay and in the community of Churchill, Manitoba, Canada. The Western Hudson Bay polar bear population declined from 1,194 (95% CI = 1,020-1,368) in 1987 to 935 (95% CI = 794-1,076) in 2004. Total apparent survival of prime-adult polar bears (5-19 yr) was stable for females (0.93; 95% CI = 0.91-0.94) and males (0.90; 95% CI = 0.88-0.91). Survival of juvenile, subadult, and senescent-adult polar bears was correlated with spring sea ice breakup date, which was variable among years and occurred approximately 3 weeks earlier in 2004 than in 1984. We propose that this correlation provides evidence for a causal association between earlier sea ice breakup (due to climatic warming) and decreased polar bear survival. It may also explain why Churchill, like other communities along the western coast of Hudson Bay, has experienced an increase in human-polar bear interactions in recent years. Earlier sea ice breakup may have resulted in a larger number of nutritionally stressed polar bears, which are encroaching on human habitations in search of supplemental food. Because western Hudson Bay is near the southern limit of the species' range, our findings may foreshadow the demographic responses and management challenges that more northerly polar bear populations will experience if climatic warming in the Arctic continues as

The two faces of selective memory retrieval: Earlier decline of the beneficial than the detrimental effect with older age.

PubMed

Aslan, Alp; Schlichting, Andreas; John, Thomas; Bäuml, Karl-Heinz T

2015-12-01

Recent work with young adults has shown that, depending on study context access, selective memory retrieval can both impair and improve recall of other memories (Bäuml & Samenieh, 2010). Here, we investigated the 2 opposing effects of selective retrieval in older age. In Experiment 1, we examined 64 younger (20-35 years) and 64 older participants (above 60 years), and manipulated study context access using list-method directed forgetting. Whereas both age groups showed a detrimental effect of selective retrieval on to-be-remembered items, only younger but not older adults showed a beneficial effect on to-be-forgotten items. In Experiment 2, we examined 112 participants from a relatively wide age range (40-85 years), and manipulated study context access by varying the retention interval between study and test. Overall, a detrimental effect of selective retrieval arose when the retention interval was relatively short, but a beneficial effect when the retention interval was prolonged. Critically, the size of the beneficial but not the detrimental effect of retrieval decreased with age and this age-related decline was mediated by individuals' working memory capacity, as measured by the complex operation span task. Together, the results suggest an age-related dissociation in retrieval dynamics, indicating an earlier decline of the beneficial than the detrimental effect of selective retrieval with older age. (c) 2015 APA, all rights reserved).

M-Mode Ultrasound Reveals Earlier Gluteus Minimus Activity in Individuals With Chronic Hip Pain During a Step-down Task.

PubMed

Dieterich, Angela V; Deshon, Louise; Strauss, Geoffrey R; McKay, Jan; Pickard, Christine M

2016-04-01

Controlled laboratory study. The hip abductor muscles are important hip joint stabilizers. Hip joint pain may alter muscle recruitment. Motion-mode (M-mode) ultrasound enables noninvasive measurements of the onset of deep and superficial muscle motion, which is associated with activation onset. To compare (1) the onset of superficial and deep gluteus medius and gluteus minimus muscle motion relative to the instant of peak ground reaction force and (2) the level of swing-phase muscle motion during step-down between subjects with chronic hip pain and controls using M-mode ultrasound. Thirty-five subjects with anterior, nontraumatic hip pain for more than 6 months (mean ± SD age, 54 ± 9 years) and 35 controls (age, 57 ± 7 years) were scanned on the lateral hip of the leading leg during frontal step-down onto a force platform using M-mode ultrasound. Computerized motion detection with the Teager-Kaiser energy operator was applied on the gluteus minimus and the deep and superficial gluteus medius to determine the time lag between muscle motion onset and instant of peak ground reaction force and the level of gluteus minimus motion during the swing phase. Time lags and motion levels were averaged per subject, and t tests were used to determine between-group differences. In participants with hip pain, gluteus minimus motion onset was 103 milliseconds earlier (P = .002) and superficial gluteus medius motion was 70 milliseconds earlier (P = .047) than those in healthy control participants. The level of gluteus minimus swing-phase motion was higher with pain (P = .006). Increased gluteus minimus motion during the swing phase and earlier gluteus minimus and superficial gluteus medius motion in individuals with hip pain suggest an overall increase of muscle activity, possibly a protective behavior.

Astrometric observations of comets and asteroids and subsequent orbital investigations

NASA Technical Reports Server (NTRS)

Mccrosky, R. E.; Marsden, B. G.

1986-01-01

During the past year some 500 observations were made on 66 nights and published on the MPCs (Minor Planet Circulars/Minor Planets and Comets). In addition, a handful of measurements of earlier plates were completed and published. 121 of the observations published referred to comets. Of special importance were observations of comets (P/Giacobini-Zinner and P/Halley) in connection with the NASA ICE and ESA Giotto missions, but a special effort was made to get good coverage of almost all of the observable comets. Observations were also made of (2060) Chiron and of the earth-approaching objects (1627) Ivar, (1866) Sisyphys, (1943) Anteros, (3362) 1984 QA, 1985 JA, PA, TB and WA, and 1986 DA and EB. 46 minor planets were given permanent numbers entirely as a result of the observations.

Earlier initialization of highly active antiretroviral therapy is associated with long-term survival and is cost-effective: findings from a deterministic model of a 10-year Ugandan cohort.

PubMed

Mills, Fergal P; Ford, Nathan; Nachega, Jean B; Bansback, Nicholas; Nosyk, Bohdan; Yaya, Sanni; Mills, Edward J

2012-11-01

Raising the guidelines for the initiation of antiretroviral therapy in resource-limited settings at CD4 T-cell counts of 350 cells per microliter raises concerns about feasibility and cost. We examined costs of this shift using data from Uganda for almost 10 years. We projected total costs of earlier initiation with combined antiretroviral therapy, including inpatient and outpatient services, antiretroviral treatment and treatment for limited HIV-related opportunistic diseases, and benefits expressed in years-of-life-saved over 5- and 30-year time horizons using a deterministic economic model to examine the incremental cost-effectiveness ratio (ICER), expressed in cost per year-of-life-saved (YLS). The model generated ICERs for 5- and 30-year time horizons. Discounting both costs and benefits at 3% annually, for the 5-year analysis, the ICER was $695/YLS and $769 in the 30-year analysis. The results were most sensitive to program cost and the discount rate applied, but they were less sensitive to opportunistic infection treatment costs or the relative-risk reduction from earlier initiation. Program costs varied from 25% to 125%, and the ICER for the lower bound decreased to $491/YLS at 5-years and $574/YLS at 30 years. For the upper bound, the ICER increased to $899 for 5-years and $964 at 30-years. The budget impact of adoption, assuming the same level of program penetration in the community, is $261,651,942 for 5 years and $872,685,561 for 30 years. Our model showed that earlier initiation of combined antiretroviral therapy in Uganda is associated with improved long-term survival and is highly cost-effective, as defined by WHO-CHOICE.

Observational evidence for black holes

NASA Astrophysics Data System (ADS)

Hutchings, J. B.

1985-02-01

Observational data supporting the existence of black holes are presented graphically and characterized in a general review. Object classes discussed include quasars as galaxy cores, X-ray-emitting binaries (Cyg X-1, LMC X-3, and the apparent miniature quasar SS 433), radio galaxies and quasars with twin jets, and interacting galaxies. This evidence is found to strongly suggest that quasars are accreting black holes of mass about 10 to the 8th solar mass, that they formed more easily in earlier stages of the universe (corresponding to redshifts around 2), and that they are analogous in many ways to the stellar-mass object SS 433.

A likely source of an observation report in Ptolemy's Almagest.

NASA Astrophysics Data System (ADS)

Jones, A.

1999-09-01

A recently publishes volume of Greek papyri from Oxyrhynchus (modern Bahnasa, Egypt) containing astronomical text, tables, and horoscopes also includes a fragment of a theoretical work on planetary theory. This text, published under the number P.Oxy. LXI 4133, contains the report of an observation of Jupiter's position in AD 104-105 and refers also to another observation of Jupiter made 344 years earlier. The author of the present note has identified tentatively Menelaus of Alexandria as the author of the treatise on planetary theory. Here, he argues that the recovered treatise was very likely Ptolemy's immediate source for the Jupiter observations referred to in the Almagest.

Transcriptional analysis of micronutrient zinc-associated response for enhanced carbohydrate utilization and earlier solventogenesis in Clostridium acetobutylicum.

PubMed

Wu, You-Duo; Xue, Chuang; Chen, Li-Jie; Wan, Hui-Hui; Bai, Feng-Wu

2015-11-20

The micronutrient zinc plays vital roles in ABE fermentation by Clostridium acetobutylicum. In order to elucidate the zinc-associated response for enhanced glucose utilization and earlier solventogenesis, transcriptional analysis was performed on cells grown in glucose medium at the exponential growth phase of 16 h without/with supplementary zinc. Correspondingly, the gene glcG (CAC0570) encoding a glucose-specific PTS was significantly upregulated accompanied with the other two genes CAC1353 and CAC1354 for glucose transport in the presence of zinc. Additionally, genes involved in the metabolisms of six other carbohydrates (maltose, cellobiose, fructose, mannose, xylose and arabinose) were differentially expressed, indicating that the regulatory effect of micronutrient zinc is carbohydrate-specific with respects to the improved/inhibited carbohydrate utilization. More importantly, multiple genes responsible for glycolysis (glcK and pykA), acidogenesis (thlA, crt, etfA, etfB and bcd) and solventogenesis (ctfB and bdhA) of C. acetobutylicum prominently responded to the supplementary zinc at differential expression levels. Comparative analysis of intracellular metabolites revealed that the branch node intermediates such as acetyl-CoA, acetoacetyl-CoA, butyl-CoA, and reducing power NADH remained relatively lower whereas more ATP was generated due to enhanced glycolysis pathway and earlier initiation of solventogenesis, suggesting that the micronutrient zinc-associated response for the selected intracellular metabolisms is significantly pleiotropic.

CCD Camera Observations

NASA Astrophysics Data System (ADS)

Buchheim, Bob; Argyle, R. W.

One night late in 1918, astronomer William Milburn, observing the region of Cassiopeia from Reverend T.H.E.C. Espin's observatory in Tow Law (England), discovered a hitherto unrecorded double star (Wright 1993). He reported it to Rev. Espin, who measured the pair using his 24-in. reflector: the fainter star was 6.0 arcsec from the primary, at position angle 162.4 ^{circ } (i.e. the fainter star was south-by-southeast from the primary) (Espin 1919). Some time later, it was recognized that the astrograph of the Vatican Observatory had taken an image of the same star-field a dozen years earlier, in late 1906. At that earlier epoch, the fainter star had been separated from the brighter one by only 4.8 arcsec, at position angle 186.2 ^{circ } (i.e. almost due south). Were these stars a binary pair, or were they just two unrelated stars sailing past each other? Some additional measurements might have begun to answer this question. If the secondary star was following a curved path, that would be a clue of orbital motion; if it followed a straight-line path, that would be a clue that these are just two stars passing in the night. Unfortunately, nobody took the trouble to re-examine this pair for almost a century, until the 2MASS astrometric/photometric survey recorded it in late 1998. After almost another decade, this amateur astronomer took some CCD images of the field in 2007, and added another data point on the star's trajectory, as shown in Fig. 15.1.

What is missing between model and Aura MLS observations in mesospheric OH?

NASA Astrophysics Data System (ADS)

Wang, S.; Li, K. F.; Zeng, Z.; Sander, S. P.; Shia, R. L.; Yung, Y. L.

2017-12-01

Recent Aura Microwave Limb Souder observations show higher mesospheric OH levels than earlier versions and previous satellite observations. The current photochemical model with standard chemistry is not able to accurately simulate MLS OH in the mesosphere. In particular, the model significantly underestimates OH over the altitude range of 60-80km. In the standard middle atmospheric chemistry, HOx over this altitude range is controled mainly through the reactions of H2O + hv (< 205 nm) → H + OH; H + O2 + M → HO2 + M; and OH + HO2 → H2O + O2. In an attempt to resolve the model-observation discrepancy, we adjust the rate coefficients of these reactions within recommended uncertainty ranges using an objective Bayesian approach. However, reasonable perturbations to these reactions are not capable of resolving the mesospheric discrepancy without introducing disagreements in other regions of the atmosphere. We explore possible new reactions in the Earth's atmosphere that are not included in current standard models. Some candidate reactions and their potential impacts on mesospheric HOx chemistry will be discussed. Our results urge new laboratory studies of these candidate reactions, whose rate coefficients have never been measured for the atmospheric conditions.

Characterizing the Asian Tropopause Aerosol Layer (ATAL) Using Satellite Observations, Balloon Measurements and a Chemical Transport Model

NASA Technical Reports Server (NTRS)

Fairlie, T. D.; Vernier, J.-P.; Liu, H.; Deshler, T.; Natarajan, M.; Bedka, K.; Wegner, T.; Baker, N.; Gadhavi, H.; Ratnam, M. V.;

Centaurus X-3 - New low- and medium-energy X-ray observations

NASA Technical Reports Server (NTRS)

Long, K.; Agrawal, P. C.; Garmire, G.

1975-01-01

Low- and medium-energy X-ray observations of Cen X-3 during two pointed sounding-rocket experiments are discussed. The lack of low-energy emission from Cen X-3 is consistent with the identification of Krzeminski's star as the optical counterpart of Cen X-3 and normal reddening, in contrast to an earlier measurement by Bleeker et al (1973).

Antiretroviral treatment-based cost saving interventions may offset expenses for new patients and earlier treatment start.

PubMed

Angeletti, C; Pezzotti, P; Antinori, A; Mammone, A; Navarra, A; Orchi, N; Lorenzini, P; Mecozzi, A; Ammassari, A; Murachelli, S; Ippolito, G; Girardi, E

2014-03-01

Combination antiretroviral therapy (cART) has become the main driver of total costs of caring for persons living with HIV (PLHIV). The present study estimated the short/medium-term cost trends in response to the recent evolution of national guidelines and regional therapeutic protocols for cART in Italy. We developed a deterministic mathematical model that was calibrated using epidemic data for Lazio, a region located in central Italy with about six million inhabitants. In the Base Case Scenario, the estimated number of PLHIV in the Lazio region increased over the period 2012-2016 from 14 414 to 17 179. Over the same period, the average projected annual cost for treating the HIV-infected population was €147.0 million. An earlier cART initiation resulted in a rise of 2.3% in the average estimated annual cost, whereas an increase from 27% to 50% in the proportion of naïve subjects starting cART with a nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimen resulted in a reduction of 0.3%. Simplification strategies based on NNRTIs co-formulated in a single tablet regimen and protease inhibitor/ritonavir-boosted monotherapy produced an overall reduction in average annual costs of 1.5%. A further average saving of 3.3% resulted from the introduction of generic antiretroviral drugs. In the medium term, cost saving interventions could finance the increase in costs resulting from the inertial growth in the number of patients requiring treatment and from the earlier treatment initiation recommended in recent guidelines. © 2013 British HIV Association.

Accreting Binary Populations in the Earlier Universe

NASA Technical Reports Server (NTRS)

Hornschemeier, Ann

2010-01-01

It is now understood that X-ray binaries dominate the hard X-ray emission from normal star-forming galaxies. Thanks to the deepest (2-4 Ms) Chandra surveys, such galaxies are now being studied in X-rays out to z approximates 4. Interesting X-ray stacking results (based on 30+ galaxies per redshift bin) suggest that the mean rest-frame 2-10 keV luminosity from z=3-4 Lyman break galaxies (LBGs), is comparable to the most powerful starburst galaxies in the local Universe. This result possibly indicates a similar production mechanism for accreting binaries over large cosmological timescales. To understand and constrain better the production of X-ray binaries in high-redshift LBGs, we have utilized XMM-Newton observations of a small sample of z approximates 0.1 GALEX-selected Ultraviolet-Luminous Galaxies (UVLGs); local analogs to high-redshift LBGs. Our observations enable us to study the X-ray emission from LBG-like galaxies on an individual basis, thus allowing us to constrain object-to-object variances in this population. We supplement these results with X-ray stacking constraints using the new 3.2 Ms Chandra Deep Field-South (completed spring 2010) and LBG candidates selected from HST, Swift UVOT, and ground-based data. These measurements provide new X-ray constraints that sample well the entire z=0-4 baseline

Earlier reperfusion in patients with ST-elevation Myocardial infarction by use of helicopter

PubMed Central

2012-01-01

Background In patients with ST-elevation myocardial infarction (STEMI) reperfusion therapy should be initiated as soon as possible. This study evaluated whether use of a helicopter for transportation of patients is associated with earlier initiation of reperfusion therapy. Material and methods A prospective study was conducted, including patients with STEMI and symptom duration less than 12 hours, who had primary percutaneous coronary intervention (PPCI) performed at Aarhus University Hospital in Skejby. Patients with a health care system delay (time from emergency call to first coronary intervention) of more than 360 minutes were excluded. The study period ran from 1.1.2011 until 31.12.2011. A Western Denmark Helicopter Emergency Medical Service (HEMS) project was initiated 1.6.2011 for transportation of patients with time-critical illnesses, including STEMI. Results The study population comprised 398 patients, of whom 376 were transported by ambulance Emergency Medical Service (EMS) and 22 by HEMS. Field-triage directly to the PCI-center was used in 338 of patients. The median system delay was 94 minutes among those field-triaged, and 168 minutes among those initially admitted to a local hospital. Patients transported by EMS and field-triaged were stratified into four groups according to transport distance from the scene of event to the PCI-center: ≤25 km., 26–50 km., 51–75 km. and > 75 km. For these groups, the median system delay was 78, 89, 99, and 141 minutes. Among patients transported by HEMS and field-triaged the estimated median transport distance by ground transportation was 115 km, and the observed system delay was 107 minutes. Based on second order polynomial regression, it was estimated that patients with a transport distance of >60 km to the PCI-center may benefit from helicopter transportation, and that transportation by helicopter is associated with a system delay of less than 120 minutes even at a transport distance up to 150 km

Earlier reperfusion in patients with ST-elevation myocardial infarction by use of helicopter.

PubMed

Knudsen, Lars; Stengaard, Carsten; Hansen, Troels Martin; Lassen, Jens Flensted; Terkelsen, Christian Juhl

2012-10-04

In patients with ST-elevation myocardial infarction (STEMI) reperfusion therapy should be initiated as soon as possible. This study evaluated whether use of a helicopter for transportation of patients is associated with earlier initiation of reperfusion therapy. A prospective study was conducted, including patients with STEMI and symptom duration less than 12 hours, who had primary percutaneous coronary intervention (PPCI) performed at Aarhus University Hospital in Skejby. Patients with a health care system delay (time from emergency call to first coronary intervention) of more than 360 minutes were excluded. The study period ran from 1.1.2011 until 31.12.2011. A Western Denmark Helicopter Emergency Medical Service (HEMS) project was initiated 1.6.2011 for transportation of patients with time-critical illnesses, including STEMI. The study population comprised 398 patients, of whom 376 were transported by ambulance Emergency Medical Service (EMS) and 22 by HEMS. Field-triage directly to the PCI-center was used in 338 of patients. The median system delay was 94 minutes among those field-triaged, and 168 minutes among those initially admitted to a local hospital. Patients transported by EMS and field-triaged were stratified into four groups according to transport distance from the scene of event to the PCI-center: ≤25 km., 26-50 km., 51-75 km. and > 75 km. For these groups, the median system delay was 78, 89, 99, and 141 minutes. Among patients transported by HEMS and field-triaged the estimated median transport distance by ground transportation was 115 km, and the observed system delay was 107 minutes. Based on second order polynomial regression, it was estimated that patients with a transport distance of >60 km to the PCI-center may benefit from helicopter transportation, and that transportation by helicopter is associated with a system delay of less than 120 minutes even at a transport distance up to 150 km. The present study indicates that use of a

Are weather models better than gridded observations for precipitation in the mountains? (Invited)

NASA Astrophysics Data System (ADS)

Gutmann, E. D.; Rasmussen, R.; Liu, C.; Ikeda, K.; Clark, M. P.; Brekke, L. D.; Arnold, J.; Raff, D. A.

2013-12-01

Mountain snowpack is a critical storage component in the water cycle, and it provides drinking water for tens of millions of people in the Western US alone. This water store is susceptible to climate change both because warming temperatures are likely to lead to earlier melt and a temporal shift of the hydrograph, and because changing atmospheric conditions are likely to change the precipitation patterns that produce the snowpack. Current measurements of snowfall in complex terrain are limited in number due in part to the logistics of installing equipment in complex terrain. We show that this limitation leads to statistical artifacts in gridded observations of current climate including errors in precipitation season totals of a factor of two or more, increases in wet day fraction, and decreases in storm intensity. In contrast, a high-resolution numerical weather model (WRF) is able to reproduce observed precipitation patterns, leading to confidence in its predictions for areas without measurements and new observations support this. Running WRF for a future climate scenario shows substantial changes in the spatial patterns of precipitation in the mountains related to the physics of hydrometeor production and detrainment that are not captured by statistical downscaling products. The stationarity in statistical downscaling products is likely to lead to important errors in our estimation of future precipitation in complex terrain.

Attachment styles, earlier interpersonal relationships and schizotypy in a non-clinical sample.

PubMed

Berry, Katherine; Band, Rebecca; Corcoran, Rhiannon; Barrowclough, Christine; Wearden, Alison

2007-12-01

This paper investigates associations between adult attachment style, relationships with significant others during childhood, traumatic life-events and schizotypy. Relationships between attachment and hypothesized correlates were investigated in a cross-sectional design using an analogue sample. The reliability of the attachment and trauma measures was investigated using a test-retest design. Three hundred and four students completed the self-report version of the Psychosis Attachment Measure (PAM), maternal and paternal versions of the Parental Bonding Instrument, the Attachment History Questionnaire, a measure of trauma and the Oxford-Liverpool Inventory of Feelings and Experiences scale through an internet website. As predicted, there were statistically significant associations between insecure attachment in adult relationships and experiences of negative interpersonal events. Both earlier interpersonal experiences and adult attachment style predicted schizotypy, and adult attachment style emerged as an independent predictor of positive schizotypal characteristics. The findings support associations between adult attachment style and previous interpersonal experiences and between adult attachment and schizotypy. The PAM is a reliable and valid instrument that can be used to explore attachment styles in analogue samples and associations between attachment styles and psychotic symptoms in clinical samples.

Earlier detection of breast cancer by surveillance of women at familial risk.

PubMed

Tilanus-Linthorst, M M; Bartels, C C; Obdeijn, A I; Oudkerk, M

2000-03-01

A positive family history increases the risk for breast cancer which oft en occurs at a much younger age than in the general population. We stud ied whether surveillance of these women resulted in the detection of bre ast cancer in an earlier stage than in symptomatic patients with a famil y history. Between January 1994 and April 1998, 294 women with 15-25% r isk (moderate), mean age:43.3 (22-75) years, were screened with a yearly physical examination and mammography from 5 years before the youngest ag e of onset in the family and 384 women with >25% risk (high) for breast cancer, mean age: 42.9 (20-74) years were screened with a physical examination every 6 months and yearly mammography. From September 1995 breast magnetic resonance imaging (MRI) was also carried out for 109 high risk women where mammography showed over 50% density. 26 breast cancers detected under surveillance were significantly more often found in an early T1N0 stage than the 24 breast cancers in patients with a family history referred in that period because of symptoms: 81 versus 46% (P=0.018). Patients under surveillance were also less frequently node-positive than the symptomatic group: 19 versus 42% (P=0.12). 20 patients with a family history referred by our national screening programme in that period had 21 breast cancers detected, 81% in stage T1N0 and 5% node-positive, which was comparable to the results in our national screening programme T1N0 66%, N+ 24% resulting in a 30% reduction in mortality. The incidence in women under surveillance was 10.1 per 1000 in the 'high' risk group and 13.3 per 1000 in the 'moderate' risk group. Expected incidence in an average risk population aged 40-50 years is 1.5, expected if the group consisted of only gene carriers 15 per 1000. 23% of the breast cancers in the surveillance group were detected at physical examination, but occult at mammography. 38% were detected at mammography and clinically occult. Breast MRI (in the subgroup) detected 3 occult

Observed Near-Surface Currents Four Super Typhoons

DTIC Science & Technology

2014-07-16

floats under category-4 hur- ricane Frances 2004 (D’Asaro et al., 2007 ; Sanford et al., 2011). Maximum current velocities of 2.0 m s−1 and 1.7 m s−1...Teague et al., 2007 ). The observed maximum current velocities and the storm’s track in the earlier studies are listed in Table 1. In addition to current...2011) 1.5 Ivan (2004), Gulf of Mexico Category-4 5.8 ADCP 15 6 Teague et al. ( 2007 ) 2.1 Harvey (2005), Atlantic Tropical storm 6.3 ADCP 5 18 Black

Hemodynamic parameters change earlier than tissue oxygen tension in hemorrhage.

PubMed

Pestel, Gunther J; Fukui, Kimiko; Kimberger, Oliver; Hager, Helmut; Kurz, Andrea; Hiltebrand, Luzius B

2010-05-15

Untreated hypovolemia results in impaired outcome. This study tests our hypothesis whether general hemodynamic parameters detect acute blood loss earlier than monitoring parameters of regional tissue beds. Eight pigs (23-25 kg) were anesthetized and mechanically ventilated. A pulmonary artery catheter and an arterial catheter were inserted. Tissue oxygen tension was measured with Clark-type electrodes in the jejunal and colonic wall, in the liver, and subcutaneously. Jejunal microcirculation was assessed by laser Doppler flowmetry (LDF). Intravascular volume was optimized using difference in pulse pressure (dPP) to keep dPP below 13%. Sixty minutes after preparation, baseline measurements were taken. At first, 5% of total blood volume was withdrawn, followed by another 5% increment, and then in 10% increments until death. After withdrawal of 5% of estimated blood volume, dPP increased from 6.1% +/- 3.0% to 20.8% +/- 2.7% (P < 0.01). Mean arterial pressure (MAP), mean pulmonary artery pressure (PAP) and pulmonary artery occlusion pressure (PAOP) decreased with a blood loss of 10% (P < 0.01). Cardiac output (CO) changed after a blood loss of 20% (P < 0.05). Tissue oxygen tension in central organs, and blood flow in the jejunal muscularis decreased (P < 0.05) after a blood loss of 20%. Tissue oxygen tension in the skin, and jejunal mucosa blood flow decreased (P < 0.05) after a blood loss of 40% and 50%, respectively. In this hemorrhagic pig model systemic hemodynamic parameters were more sensitive to detect acute hypovolemia than tissue oxygen tension measurements or jejunal LDF measurements. Acute blood loss was detected first by dPP. Copyright (c) 2010 Elsevier Inc. All rights reserved.

The response of aboveground plant productivity to earlier snowmelt and summer warming in an Arctic ecosystem

NASA Astrophysics Data System (ADS)

Livensperger, C.; Steltzer, H.; Darrouzet-Nardi, A.; Sullivan, P.; Wallenstein, M. D.; Weintraub, M. N.

2012-12-01

Plant communities in the Arctic are undergoing changes in structure and function due to shifts in seasonality from changing winters and summer warming. These changes will impact biogeochemical cycling, surface energy balance, and functioning of vertebrate and invertebrate communities. To examine seasonal controls on aboveground net primary production (ANPP) in a moist acidic tundra ecosystem in northern Alaska, we shifted the growing season by accelerating snowmelt (using radiation absorbing shadecloth) and warming air and soil temperature (using 1 m2 open-top chambers), individually and in combination. After three years, we measured ANPP by harvesting up to 16 individual ramets, tillers and rhizomes for each of 7 plant species, including two deciduous shrubs, two graminoids, two evergreen shrubs and one forb during peak season. Our results show that ANPP per stem summed across the 7 species increased when snow melt occurred earlier. However, standing biomass, excluding current year growth, was also greater. The ratio of ANPP/standing biomass decreased in all treatments compared to the control. ANPP per unit standing biomass summed for the four shrub species decreases due to summer warming alone or in combination with early snowmelt; however early snowmelt alone did not lead to lower ANPP for the shrubs. ANPP per tiller or rhizome summed for the three herbaceous species increased in response to summer warming. Understanding the differential response of plants to changing seasonality will inform predictions of future Arctic plant community structure and function.

Does earlier arrival of the retrieval team improve short-term outcomes in outborn extremely premature infants?

PubMed

Sharpe, Janet B; Davies, Mark W

2018-05-31

The risk of mortality and morbidity is increased in outborn, extremely premature infants. We aim to determine whether earlier arrival of the retrieval team after the birth of infants less than 29 weeks gestation improves short-term mortality and morbidity. This is a retrospective analysis of a cohort of infants less than 29 weeks gestation who were retrieved to the Royal Brisbane and Women's Hospital (RBWH) over a 5-year period. Demographic information regarding the infant and mother, retrieval team arrival time and outcome data was collected. Primary outcomes investigated were mortality prior to discharge from hospital or a composite of mortality or severe intraventricular haemorrhage (IVH). Data on 105 infants were analysed; 88 infants (83.8%) survived to discharge home, and 79 (75.2%) survived to discharge without severe IVH. On univariate analysis, there was no significant association between age at arrival of the retrieval team and death prior to discharge (P = 0.94) or death prior to discharge or severe IVH (P = 0.83). On logistic regression analysis, age at arrival of retrieval team remained non-significant for a reduction in death prior to discharge and composite of death or severe IVH (P = 0.70 and P = 0.99, respectively). The earlier arrival of the retrieval team is not associated with improved short-term outcomes in outborn, extremely preterm infants who are retrieved and admitted to a tertiary neonatal intensive care unit - for infants where the retrieval team arrived within about 8 h of birth. © 2018 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).

IUE observations of faint comets

NASA Technical Reports Server (NTRS)

Weaver, H. A.; Feldman, P. D.; Festou, M. C.; Ahearn, M. F.; Keller, H. U.

1981-01-01

Ultraviolet spectra of seven comets taken with the same instrument are given. The comets P/Encke (1980), P/Tuttle (1980 h), P/Stephan-Oterma (1980 g), and Meier (1980 q) were observed in November and December 1980 with the IUE satellite, and comets P/Borrelly (1980 i) and Panther (1980 u) were observed with the IUE on March 6, 1981. The spectra of these comets are compared with one another, as well as with comet Bradfield (1978 X), which was extensively studied earlier in 1980 with the IUE. To simplify the interpretation of the data and to minimize the dependence upon a specific model, the spectra are compared at approximately the same value of heliocentric distance whenever possible. Effects arising from heliocentric velocity, geocentric distance, and optical depth are also discussed. All of the cometary spectra are found to be remarkably similar, suggesting that these comets may have a common composition and origin.

IUE observations of faint comets

NASA Astrophysics Data System (ADS)

Weaver, H. A.; Feldman, P. D.; Festou, M.; A'Hearn, M. F.; Keller, H. U.

1981-09-01

Ultraviolet spectra of seven comets taken with the same instrument are given. The comets P/Encke (1980), P/Tuttle (1980 h), P/Stephan-Oterma (1980 g), and Meier (1980 q) were observed in November and December 1980 with the IUE satellite, and comets P/Borrelly (1980 i) and Panther (1980 u) were observed with the IUE on March 6, 1981. The spectra of these comets are compared with one another, as well as with comet Bradfield (1978 X), which was extensively studied earlier in 1980 with the IUE. To simplify the interpretation of the data and to minimize the dependence upon a specific model, the spectra are compared at approximately the same value of heliocentric distance whenever possible. Effects arising from heliocentric velocity, geocentric distance, and optical depth are also discussed. All of the cometary spectra are found to be remarkably similar, suggesting that these comets may have a common composition and origin.

Mesoscale influence on long-range transport — evidence from ETEX modelling and observations

NASA Astrophysics Data System (ADS)

Sørensen, Jens Havskov; Rasmussen, Alix; Ellermann, Thomas; Lyck, Erik

During the first European Tracer Experiment (ETEX) tracer gas was released from a site in Brittany, France, and subsequently observed over a range of 2000 km. Hourly measurements were taken at the National Environmental Research Institute (NERI) located at Risø, Denmark, using two measurement techniques. At this location, the observed concentration time series shows a double-peak structure occurring between two and three days after the release. By using the Danish Emergency Response Model of the Atmosphere (DERMA), which is developed at the Danish Meteorological Institute (DMI), simulations of the dispersion of the tracer gas have been performed. Using numerical weather-prediction data from the European Centre for Medium-Range Weather Forecast (ECMWF) by DERMA, the arrival time of the tracer is quite well predicted, so also is the duration of the passage of the plume, but the double-peak structure is not reproduced. However, using higher-resolution data from the DMI version of the HIgh Resolution Limited Area Model (DMI-HIRLAM), DERMA reproduces the observed structure very well. The double-peak structure is caused by the influence of a mesoscale anti-cyclonic eddy on the tracer gas plume about one day earlier.

Siberian Arctic black carbon sources constrained by model and observation

PubMed Central

Andersson, August; Eckhardt, Sabine; Stohl, Andreas; Semiletov, Igor P.; Dudarev, Oleg V.; Charkin, Alexander; Shakhova, Natalia; Klimont, Zbigniew; Heyes, Chris; Gustafsson, Örjan

2017-01-01

Black carbon (BC) in haze and deposited on snow and ice can have strong effects on the radiative balance of the Arctic. There is a geographic bias in Arctic BC studies toward the Atlantic sector, with lack of observational constraints for the extensive Russian Siberian Arctic, spanning nearly half of the circum-Arctic. Here, 2 y of observations at Tiksi (East Siberian Arctic) establish a strong seasonality in both BC concentrations (8 ng⋅m−3 to 302 ng⋅m−3) and dual-isotope–constrained sources (19 to 73% contribution from biomass burning). Comparisons between observations and a dispersion model, coupled to an anthropogenic emissions inventory and a fire emissions inventory, give mixed results. In the European Arctic, this model has proven to simulate BC concentrations and source contributions well. However, the model is less successful in reproducing BC concentrations and sources for the Russian Arctic. Using a Bayesian approach, we show that, in contrast to earlier studies, contributions from gas flaring (6%), power plants (9%), and open fires (12%) are relatively small, with the major sources instead being domestic (35%) and transport (38%). The observation-based evaluation of reported emissions identifies errors in spatial allocation of BC sources in the inventory and highlights the importance of improving emission distribution and source attribution, to develop reliable mitigation strategies for efficient reduction of BC impact on the Russian Arctic, one of the fastest-warming regions on Earth. PMID:28137854

An inhibitor of polyamine synthesis arrests cells at an earlier stage of G1 than does calcium deprivation.

PubMed Central

Cheetham, B F

1983-01-01

Methylglyoxal bis(guanylhydrazone) completely inhibits the induction of thymidine kinase after serum stimulation of quiescent fibroblasts only if added within 3 h after serum, whereas calcium deprivation blocks this induction up to 12 h after serum stimulation. Experiments in which one of these blocks was imposed as the other was released confirmed that cells blocked by methylglyoxal bis(guanylhydrazone) are arrested at an earlier stage in G1 than cells blocked by calcium deprivation. PMID:6843551

Observational study of atmospheric surface layer and coastal weather in northern Qatar

NASA Astrophysics Data System (ADS)

Samanta, Dhrubajyoti; Sadr, Reza

2016-04-01

Atmospheric surface layer is the interaction medium between atmosphere and Earth's surface. Better understanding of its turbulence nature is essential in characterizing the local weather, climate variability and modeling of turbulent exchange processes. The importance of Middle East region, with its unique geographical, economical and weather condition is well recognized. However, high quality micrometeorological observational studies are rare in this region. Here we show experimental results from micrometeorological observations from an experimental site in the coastal region of Qatar during August-December 2015. Measurements of winds are obtained from three sonic anemometers installed on a 9 m tower placed at Al Ghariyah beach in northern Qatar (26.08 °N, 51.36 °E). Different surface layer characteristics is analyzed and compared with earlier studies in equivalent weather conditions. Monthly statistics of wind speed, wind direction, temperature, humidity and heat index are made from concurrent observations from sonic anemometer and weather station to explore variations with surface layer characteristics. The results also highlights potential impact of sea breeze circulation on local weather and atmospheric turbulence. The observed daily maximum temperature and heat index during morning period may be related to sea breeze circulations. Along with the operational micrometeorological observation system, a camera system and ultrasonic wave measurement system are installed recently in the site to study coastline development and nearshore wave dynamics. Overall, the complete observational set up is going to provide new insights about nearshore wind dynamics and wind-wave interaction in Qatar.

Comparison of Observational Methods and Their Relation to Ratings of Engagement in Young Children

ERIC Educational Resources Information Center

Wood, Brenna K.; Hojnoski, Robin L.; Laracy, Seth D.; Olson, Christopher L.

2016-01-01

Although, collectively, results of earlier direct observation studies suggest momentary time sampling (MTS) may offer certain technical advantages over whole-interval (WIR) and partial-interval (PIR) recording, no study has compared these methods for measuring engagement in young children in naturalistic environments. This study compared direct…

Observed and modelled stability of overflow across the Greenland-Scotland ridge.

PubMed

Olsen, Steffen M; Hansen, Bogi; Quadfasel, Detlef; Østerhus, Svein

2008-09-25

Across the Greenland-Scotland ridge there is a continuous flow of cold dense water, termed 'overflow', from the Nordic seas to the Atlantic Ocean. This is a main contributor to the production of North Atlantic Deep Water that feeds the lower limb of the Atlantic meridional overturning circulation, which has been predicted to weaken as a consequence of climate change. The two main overflow branches pass the Denmark Strait and the Faroe Bank channel. Here we combine results from direct current measurements in the Faroe Bank channel for 1995-2005 with an ensemble hindcast experiment for 1948-2005 using an ocean general circulation model. For the overlapping period we find a convincing agreement between model simulations and observations on monthly to interannual timescales. Both observations and model data show no significant trend in volume transport. In addition, for the whole 1948-2005 period, the model indicates no persistent trend in the Faroe Bank channel overflow or in the total overflow transport, in agreement with the few available historical observations. Deepening isopycnals in the Norwegian Sea have tended to decrease the pressure difference across the Greenland-Scotland ridge, but this has been compensated for by the effect of changes in sea level. In contrast with earlier studies, we therefore conclude that the Faroe Bank channel overflow, and also the total overflow, did not decrease consistently from 1950 to 2005, although the model does show a weakening total Atlantic meridional overturning circulation as a result of changes south of the Greenland-Scotland ridge.

Interpreting Observations of Large-Scale Traveling Ionospheric Disturbances by Ionospheric Sounders

NASA Astrophysics Data System (ADS)

Pederick, L. H.; Cervera, M. A.; Harris, T. J.

2017-12-01

From July to October 2015, the Australian Defence Science and Technology Group conducted an experiment during which a vertical incidence sounder (VIS) was set up at Alice Springs Airport. During September 2015 this VIS observed the passage of many large-scale traveling ionospheric disturbances (TIDs). By plotting the measured virtual heights across multiple frequencies as a function of time, the passage of the TID can be clearly displayed. Using this plotting method, we show that all the TIDs observed during the campaign by the VIS at Alice Springs show an apparent downward phase progression of the crests and troughs. The passage of the TID can be more clearly interpreted by plotting the true height of iso-ionic contours across multiple plasma frequencies; the true heights can be obtained by inverting each ionogram to obtain an electron density profile. These plots can be used to measure the vertical phase speed of a TID and also reveal a time lag between events seen in true height compared to virtual height. To the best of our knowledge, this style of analysis has not previously been applied to other swept-frequency sounder observations. We develop a simple model to investigate the effect of the passage of a large-scale TID on a VIS. The model confirms that for a TID with a downward vertical phase progression, the crests and troughs will appear earlier in virtual height than in true height and will have a smaller apparent speed in true height than in virtual height.

VLA observations of radio sources in interacting galaxy pairs in poor clusters

NASA Technical Reports Server (NTRS)

Batuski, David J.; Hanisch, Robert J.; Burns, Jack O.

1992-01-01

Observations of 16 radio sources in interacting galaxies in 14 poor clusters were made using the Very Large Array in the B configuration at lambda of 6 and 2 cm. These sources had been unresolved in earlier observations at lambda of 21 cm, and were chosen as a sample to determine which of three models for radio source formation actually pertains in interacting galaxies. From the analysis of this sample, the starburst model appears most successful, but the 'central monster' model could pertain in some cases.

Causal inference in survival analysis using pseudo-observations.

PubMed

Andersen, Per K; Syriopoulou, Elisavet; Parner, Erik T

2017-07-30

Causal inference for non-censored response variables, such as binary or quantitative outcomes, is often based on either (1) direct standardization ('G-formula') or (2) inverse probability of treatment assignment weights ('propensity score'). To do causal inference in survival analysis, one needs to address right-censoring, and often, special techniques are required for that purpose. We will show how censoring can be dealt with 'once and for all' by means of so-called pseudo-observations when doing causal inference in survival analysis. The pseudo-observations can be used as a replacement of the outcomes without censoring when applying 'standard' causal inference methods, such as (1) or (2) earlier. We study this idea for estimating the average causal effect of a binary treatment on the survival probability, the restricted mean lifetime, and the cumulative incidence in a competing risks situation. The methods will be illustrated in a small simulation study and via a study of patients with acute myeloid leukemia who received either myeloablative or non-myeloablative conditioning before allogeneic hematopoetic cell transplantation. We will estimate the average causal effect of the conditioning regime on outcomes such as the 3-year overall survival probability and the 3-year risk of chronic graft-versus-host disease. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

MERLIN observations of water maser proper motions in VY Canis Majoris

NASA Astrophysics Data System (ADS)

Richards, A. M. S.; Yates, J. A.; Cohen, R. J.

1998-09-01

MERLIN observations of the 22-GHz water masers in the circumstellar envelope of the supergiant VY CMa show an ellipsoidal distribution with a maximum extent of 700 mas east-west and 400 mas north-south. Comparison with observations made nine years earlier shows that the majority of maser features have survived and show proper motions throughout the region. The mean change in position is 28 mas and the proper motions are generally directed away from the assumed stellar position, and tend to be larger for features at greater projected distances. If the H_2O maser region is modelled as a partially filled thick spherical shell, and VY CMa is at a distance of 1.5 kpc, then the proper motion velocities in the direction of expansion are between 8kms^-1 at a distance of 75 mas from the assumed stellar position and 32kms^-1 at 360 mas. These velocities are consistent with the H_2O maser spectral line velocities which correspond to a maximum expansion velocity of 36kms^-1 at 400 mas from the assumed stellar position. These observations are consistent with radiation pressure on dust providing the force to accelerate the stellar wind as it passes through the H_2O maser shell. The H_2O maser region is elongated in the same direction as the dusty nebula around VY CMa. The water masers illuminate the small-scale dynamics and clumpiness which show the role of dust in driving the outflow. The overall ellipsoidal shape may be due to properties of the dust, such as its behaviour in the stellar magnetic field, or to interaction between the wind and circumstellar material. Maser monitoring also shows the difference between changes on the time-scale of stellar variability (a few years) and possible stages in the evolution of VY CMa to its likely fate as a supernova.

Three-Dimensional Properties of Coronal Mass Ejections from STEREO/SECCHI Observations

NASA Astrophysics Data System (ADS)

Bosman, E.; Bothmer, V.; Nisticò, G.; Vourlidas, A.; Howard, R. A.; Davies, J. A.

2012-11-01

We identify 565 coronal mass ejections (CMEs) between January 2007 and December 2010 in observations from the twin STEREO/SECCHI/COR2 coronagraphs aboard the STEREO mission. Our list is in full agreement with the corresponding SOHO/LASCO CME Catalog (http://cdaw.gsfc.nasa.gov/CME_list/) for events with angular widths of 45∘ and up. The monthly event rates behave similarly to sunspot rates showing a three- to fourfold rise between September 2009 and March 2010. We select 51 events with well-defined white-light structure and model them as three-dimensional (3D) flux ropes using a forward-modeling technique developed by Thernisien, Howard and Vourlidas (Astrophys. J. 652, 763 - 773, 2006). We derive their 3D properties and identify their source regions. We find that the majority of the CME flux ropes (82 %) lie within 30∘ of the solar equator. Also, 82 % of the events are displaced from their source region, to a lower latitude, by 25∘ or less. These findings provide strong support for the deflection of CMEs towards the solar equator reported in earlier observations, e.g. by Cremades and Bothmer ( Astron. Astrophys. 422, 307 - 322, 2004).

Permian tetrapods from the Sahara show climate-controlled endemism in Pangaea.

PubMed

Sidor, Christian A; O'Keefe, F Robin; Damiani, Ross; Steyer, J Sébastien; Smith, Roger M H; Larsson, Hans C E; Sereno, Paul C; Ide, Oumarou; Maga, Abdoulaye

2005-04-14

New fossils from the Upper Permian Moradi Formation of northern Niger provide an insight into the faunas that inhabited low-latitude, xeric environments near the end of the Palaeozoic era (approximately 251 million years ago). We describe here two new temnospondyl amphibians, the cochleosaurid Nigerpeton ricqlesi gen. et sp. nov. and the stem edopoid Saharastega moradiensis gen. et sp. nov., as relicts of Carboniferous lineages that diverged 40-90 million years earlier. Coupled with a scarcity of therapsids, the new finds suggest that faunas from the poorly sampled xeric belt that straddled the Equator during the Permian period differed markedly from well-sampled faunas that dominated tropical-to-temperate zones to the north and south. Our results show that long-standing theories of Late Permian faunal homogeneity are probably oversimplified as the result of uneven latitudinal sampling.

Analysis of arrhythmic events is useful to detect lead failure earlier in patients followed by remote monitoring.

PubMed

Nishii, Nobuhiro; Miyoshi, Akihito; Kubo, Motoki; Miyamoto, Masakazu; Morimoto, Yoshimasa; Kawada, Satoshi; Nakagawa, Koji; Watanabe, Atsuyuki; Nakamura, Kazufumi; Morita, Hiroshi; Ito, Hiroshi

2018-03-01

Remote monitoring (RM) has been advocated as the new standard of care for patients with cardiovascular implantable electronic devices (CIEDs). RM has allowed the early detection of adverse clinical events, such as arrhythmia, lead failure, and battery depletion. However, lead failure was often identified only by arrhythmic events, but not impedance abnormalities. To compare the usefulness of arrhythmic events with conventional impedance abnormalities for identifying lead failure in CIED patients followed by RM. CIED patients in 12 hospitals have been followed by the RM center in Okayama University Hospital. All transmitted data have been analyzed and summarized. From April 2009 to March 2016, 1,873 patients have been followed by the RM center. During the mean follow-up period of 775 days, 42 lead failure events (atrial lead 22, right ventricular pacemaker lead 5, implantable cardioverter defibrillator [ICD] lead 15) were detected. The proportion of lead failures detected only by arrhythmic events, which were not detected by conventional impedance abnormalities, was significantly higher than that detected by impedance abnormalities (arrhythmic event 76.2%, 95% CI: 60.5-87.9%; impedance abnormalities 23.8%, 95% CI: 12.1-39.5%). Twenty-seven events (64.7%) were detected without any alert. Of 15 patients with ICD lead failure, none has experienced inappropriate therapy. RM can detect lead failure earlier, before clinical adverse events. However, CIEDs often diagnose lead failure as just arrhythmic events without any warning. Thus, to detect lead failure earlier, careful human analysis of arrhythmic events is useful. © 2017 Wiley Periodicals, Inc.

The Observation of Bahasa Indonesia Official Computer Terms Implementation in Scientific Publication

NASA Astrophysics Data System (ADS)

Gunawan, D.; Amalia, A.; Lydia, M. S.; Muthaqin, M. I.

2018-03-01

The government of the Republic of Indonesia had issued a regulation to substitute computer terms in foreign language that have been used earlier into official computer terms in Bahasa Indonesia. This regulation was stipulated in Presidential Decree No. 2 of 2001 concerning the introduction of official computer terms in Bahasa Indonesia (known as Senarai Padanan Istilah/SPI). After sixteen years, people of Indonesia, particularly for academics, should have implemented the official computer terms in their official publications. This observation is conducted to discover the implementation of official computer terms usage in scientific publications which are written in Bahasa Indonesia. The data source used in this observation are the publications by the academics, particularly in computer science field. The method used in the observation is divided into four stages. The first stage is metadata harvesting by using Open Archive Initiative - Protocol for Metadata Harvesting (OAI-PMH). Second, converting the harvested document (in pdf format) to plain text. The third stage is text-preprocessing as the preparation of string matching. Then the final stage is searching the official computer terms based on 629 SPI terms by using Boyer-Moore algorithm. We observed that there are 240,781 foreign computer terms in 1,156 scientific publications from six universities. This result shows that the foreign computer terms are still widely used by the academics.

Observed oil and gas field size distributions: A consequence of the discovery process and prices of oil and gas

USGS Publications Warehouse

Drew, L.J.; Attanasi, E.D.; Schuenemeyer, J.H.

1988-01-01

If observed oil and gas field size distributions are obtained by random samplings, the fitted distributions should approximate that of the parent population of oil and gas fields. However, empirical evidence strongly suggests that larger fields tend to be discovered earlier in the discovery process than they would be by random sampling. Economic factors also can limit the number of small fields that are developed and reported. This paper examines observed size distributions in state and federal waters of offshore Texas. Results of the analysis demonstrate how the shape of the observable size distributions change with significant hydrocarbon price changes. Comparison of state and federal observed size distributions in the offshore area shows how production cost differences also affect the shape of the observed size distribution. Methods for modifying the discovery rate estimation procedures when economic factors significantly affect the discovery sequence are presented. A primary conclusion of the analysis is that, because hydrocarbon price changes can significantly affect the observed discovery size distribution, one should not be confident about inferring the form and specific parameters of the parent field size distribution from the observed distributions. ?? 1988 International Association for Mathematical Geology.

Antiparkinson drug--Mucuna pruriens shows antioxidant and metal chelating activity.

PubMed

Dhanasekaran, Muralikrishnan; Tharakan, Binu; Manyam, Bala V

2008-01-01

Parkinson's disease is a neurodegenerative disorder for which no neurorestorative therapeutic treatment is currently available. Oxidative stress plays an important role in the pathophysiology of Parkinson's disease. The ancient Indian medical system, Ayurveda, traditionally uses Mucuna pruriens to treat Parkinson's disease. In our earlier studies, Mucuna pruriens has been shown to possess antiparkinson and neuroprotective effects in animal models of Parkinson's disease. The antioxidant activity of Mucuna pruriens was demonstrated by its ability to scavenge DPPH radicals, ABTS radicals and reactive oxygen species. Mucuna pruriens significantly inhibited the oxidation of lipids and deoxyribose sugar. Mucuna pruriens exhibited divalent iron chelating activity and did not show any genotoxic/mutagenic effect on the plasmid DNA. These results suggest that the neuroprotective and neurorestorative effect of Mucuna pruriens may be related to its antioxidant activity independent of the symptomatic effect. In addition, the drug appears to be therapeutically safe in the treatment of patients with Parkinson's disease. Copyright (c) 2007 John Wiley & Sons, Ltd.

New observational project for revealing natural and anthropogenic threats at the near-Earth space

NASA Astrophysics Data System (ADS)

Harutyunian, Haik A.; Nikoghosyan, Elena H.; Melikian, Norayr D.; Azatyan, Naira M.; Abrahamyan, Hayk V.; Paronyan, Gurgen M.; Andreasyan, Hasmik R.; Ohanian, Gabriel A.; Gevorgyan, Mkrtich H.; Mikayelyan, Gor A.

2017-12-01

In 2014, a new monitoring project started at the observational base Saravand of the Byurakan astrophysical observatory. This project initiated for revealing natural and artificial objects at the near-Earth space. This is a kind of continuation of earlier observational projects implemented at the observatory prior the collapse of Soviet Union. This time, near-Earth space monitoring is carried out at the request of the Russian agency ROSKOSMOS. For observations, the EOP-1 module is used, which includes small telescopes with a mirror diameter of 40cm, 25cm and 19cm.

Study Shows Importance of Early End-of-Life Care Discussions

Cancer.gov

Discussions about palliative and end-of-life care are often delayed until late in a patient's life, if they take place at all. Earlier discussions may help to ensure that the care delivered at the end of life is consistent with a patient's preferences.

The temperature and density structures of an X-ray flare during the decay phase. [Skylab observations

NASA Technical Reports Server (NTRS)

Silk, J. K.; Kahler, S. W.; Krieger, A. S.; Vaiana, G. S.

1976-01-01

The X-ray flare of 9 August 1973 was characterized by a spatially small kernel structure which persisted throughout its duration. The decay phase of this flare was observed in the objective grating mode of the X-ray telescope aboard the Skylab. Data analysis was carried out by scanning the images with a microdensitometer, converting the density arrays to energy using laboratory film calibration data and taking cross sections of the energy images. The 9 August flare shows two distinct periods in its decay phase, involving both cooling and material loss. The objective grating observations reveal that the two phenomena are separated in time. During the earlier phase of the flare decay, the distribution of emission measure as a function of temperature is changing, the high temperature component of the distribution being depleted relative to the cooler body of plasma. As the decay continues, the emission measure distribution stabilizes and the flux diminishes as the amount of material at X-ray emitting temperatures decreases.

Family Interaction in the Newborn Period: Some Findings, Some Observations, and Some Unresolved Issues.

ERIC Educational Resources Information Center

Parke, Ross D.

This paper presents two studies which explored the manner in which the father interacts with his newborn infant and compared paternal and maternal interaction patterns. In contrast to earlier studies, a direct observational approach was employed that permitted a detailed specification of father behaviors in the presence of the newborn. In the…

How to Develop Critical Thinking Skills Within the Armys Officer Education System (OES) Earlier in an Officer’s Career

DTIC Science & Technology

2016-02-13

thinking emerges.”31 Military leaders should minimize bureaucracy when possible in an attempt to facilitate creative thinking . Consequently, a...AIR WAR COLLEGE AIR UNIVERSITY HOW TO DEVELOP CRITICAL THINKING SKILLS WITHIN THE ARMY’S OFFICER EDUCTION SYSTEM (OES) EARLIER IN AN...Force Dragon’s Heart.” iv Abstract Critical thinking skills are required by strategic leaders to solve complex problems in an environment

77 FR 22844 - Agency Information Collection Activity Under OMB Review: Uniform Criteria for State Observational...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-17

... the States have accumulated substantial experience in the design and implementation of these surveys... observational surveys is to include a specification of the survey design, to be reassessed and, if appropriate, updated every five (5) years, or earlier if the State so desires. The survey design specification will...

Health care strategies to promote earlier presentation of symptomatic breast cancer: perspectives of women and family physicians

PubMed Central

Heisey, R.; Clemons, M.; Granek, L.; Fergus, K.; Hum, S.; Lord, B.; McCready, D.R.; Fitzgerald, B.

2011-01-01

Background Many women with symptoms suggestive of a breast cancer diagnosis delay presentation to their family physician. Although factors associated with delay have been well described, there is a paucity of data on strategies to mitigate delay. Objectives We conducted a qualitative research project to examine factors related to delay and to identify health care system changes that might encourage earlier presentation. Methods Individual semi-structured interviews were conducted with women who sought care 12 weeks or more after self-detection of breast cancer symptoms and with family physicians whose practices included patients meeting that criterion. Results The women and physicians both suggested a need for clearer screening mammography guidelines for women 40–49 years of age and for better messaging concerning breast awareness. The use of additional hopeful testimonials from breast cancer survivors were suggested to help dispel the notion of cancer as a “death sentence.” Educational initiatives were proposed, aimed at both increasing awareness of “non-lump” breast cancer symptoms and advising women that a previous benign diagnosis does not ensure that future symptoms are not cancer. Women wanted empathic nonjudgmental access to care. Improved methods to track compliance with screening mammography and with periodic health exams and access to a rapid diagnostic process were suggested. Conclusions A list of “at-risk situations for delay” in diagnosis of breast cancer was developed for physicians to assist in identifying women who might delay. Health care system changes actionable both at the health policy level and in the family physician’s office were identified to encourage earlier presentation of women with symptomatic breast cancer. PMID:21980254

Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy.

PubMed

Babayan, Simon A; Read, Andrew F; Lawrence, Rachel A; Bain, Odile; Allen, Judith E

2010-10-19

Humans and other mammals mount vigorous immune assaults against helminth parasites, yet there are intriguing reports that the immune response can enhance rather than impair parasite development. It has been hypothesized that helminths, like many free-living organisms, should optimize their development and reproduction in response to cues predicting future life expectancy. However, immune-dependent development by helminth parasites has so far eluded such evolutionary explanation. By manipulating various arms of the immune response of experimental hosts, we show that filarial nematodes, the parasites responsible for debilitating diseases in humans like river blindness and elephantiasis, accelerate their development in response to the IL-5 driven eosinophilia they encounter when infecting a host. Consequently they produce microfilariae, their transmission stages, earlier and in greater numbers. Eosinophilia is a primary host determinant of filarial life expectancy, operating both at larval and at late adult stages in anatomically and temporally separate locations, and is implicated in vaccine-mediated protection. Filarial nematodes are therefore able to adjust their reproductive schedules in response to an environmental predictor of their probability of survival, as proposed by evolutionary theory, thereby mitigating the effects of the immune attack to which helminths are most susceptible. Enhancing protective immunity against filarial nematodes, for example through vaccination, may be less effective at reducing transmission than would be expected and may, at worst, lead to increased transmission and, hence, pathology.

Patterns and Variability in Global Ocean Chlorophyll: Satellite Observations and Modeling

NASA Technical Reports Server (NTRS)

Gregg, Watson

2004-01-01

Recent analyses of SeaWiFS data have shown that global ocean chlorophyll has increased more than 4% since 1998. The North Pacific ocean basin has increased nearly 19%. These trend analyses follow earlier results showing decadal declines in global ocean chlorophyll and primary production. To understand the causes of these changes and trends we have applied the newly developed NASA Ocean Biogeochemical Assimilation Model (OBAM), which is driven in mechanistic fashion by surface winds, sea surface temperature, atmospheric iron deposition, sea ice, and surface irradiance. The model utilizes chlorophyll from SeaWiFS in a daily assimilation. The model has in place many of the climatic variables that can be expected to produce the changes observed in SeaWiFS data. This enables us to diagnose the model performance, the assimilation performance, and possible causes for the increase in chlorophyll. A full discussion of the changes and trends, possible causes, modeling approaches, and data assimilation will be the focus of the seminar.

New observations on maternal age effect on germline de novo mutations.

PubMed

Wong, Wendy S W; Solomon, Benjamin D; Bodian, Dale L; Kothiyal, Prachi; Eley, Greg; Huddleston, Kathi C; Baker, Robin; Thach, Dzung C; Iyer, Ramaswamy K; Vockley, Joseph G; Niederhuber, John E

2016-01-19

Germline mutations are the source of evolution and contribute substantially to many health-related processes. Here we use whole-genome deep sequencing data from 693 parents-offspring trios to examine the de novo point mutations (DNMs) in the offspring. Our estimate for the mutation rate per base pair per generation is 1.05 × 10(-8), well within the range of previous studies. We show that maternal age has a small but significant correlation with the total number of DNMs in the offspring after controlling for paternal age (0.51 additional mutations per year, 95% CI: 0.29, 0.73), which was not detectable in the smaller and younger parental cohorts of earlier studies. Furthermore, while the total number of DNMs increases at a constant rate for paternal age, the contribution from the mother increases at an accelerated rate with age.These observations have implications related to the incidence of de novo mutations relating to maternal age.

An XMM-Newton Observation of the Seyfert Galaxy 1H0419-577 in an Extreme Low State

NASA Technical Reports Server (NTRS)

Pounds, K. A.; Reeves, J. N.; Page, K. L.; O'Brien, P. T.

2003-01-01

Previous observations of the luminous Seyfert galaxy 1H 0419-577 have found its X-ray spectrum to range from that of a typical Seyfert 1 with 2-10 keV power law index Gamma approx. 1.9 to a much flatter power law of Gamma approx. 1.5 or less. We report here a new XMM-Newton observation which allows the low state spectrum to be studied in much greater detail than hitherto. We find a very hard spectrum (Gamma approx. 1.0) which exhibits broad features that can be modelled with the addition of an extreme relativistic Fe K emission line or with partial covering of the underlying continuum by a substantial column density of near-neutral gas. Both the EPIC and RGS data show evidence for strong line emission of OVII and OVIII requiring an extended region of low density photoionised gas in 1H 0419- 577. Comparison with an earlier XMM-Newton observation when 1H 0419-577 was X-ray bright indicates the dominant spectral variability occurs via a steep power law component.

A SOLAR CYCLE LOST IN 1793-1800: EARLY SUNSPOT OBSERVATIONS RESOLVE THE OLD MYSTERY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Usoskin, Ilya G.; Mursula, Kalevi; Arlt, Rainer

2009-08-01

Because of the lack of reliable sunspot observations, the quality of the sunspot number series is poor in the late 18th century, leading to the abnormally long solar cycle (1784-1799) before the Dalton minimum. Using the newly recovered solar drawings by the 18-19th century observers Staudacher and Hamilton, we construct the solar butterfly diagram, i.e., the latitudinal distribution of sunspots in the 1790s. The sudden, systematic occurrence of sunspots at high solar latitudes in 1793-1796 unambiguously shows that a new cycle started in 1793, which was lost in the traditional Wolf sunspot series. This finally confirms the existence of themore » lost cycle that has been proposed earlier, thus resolving an old mystery. This Letter brings the attention of the scientific community to the need of revising the sunspot series in the 18th century. The presence of a new short, asymmetric cycle implies changes and constraints to sunspot cycle statistics, solar activity predictions, and solar dynamo theories, as well as for solar-terrestrial relations.« less

Observations of an extreme storm in interplanetary space caused by successive coronal mass ejections.

PubMed

Liu, Ying D; Luhmann, Janet G; Kajdič, Primož; Kilpua, Emilia K J; Lugaz, Noé; Nitta, Nariaki V; Möstl, Christian; Lavraud, Benoit; Bale, Stuart D; Farrugia, Charles J; Galvin, Antoinette B

2014-03-18

Space weather refers to dynamic conditions on the Sun and in the space environment of the Earth, which are often driven by solar eruptions and their subsequent interplanetary disturbances. It has been unclear how an extreme space weather storm forms and how severe it can be. Here we report and investigate an extreme event with multi-point remote-sensing and in situ observations. The formation of the extreme storm showed striking novel features. We suggest that the in-transit interaction between two closely launched coronal mass ejections resulted in the extreme enhancement of the ejecta magnetic field observed near 1 AU at STEREO A. The fast transit to STEREO A (in only 18.6 h), or the unusually weak deceleration of the event, was caused by the preconditioning of the upstream solar wind by an earlier solar eruption. These results provide a new view crucial to solar physics and space weather as to how an extreme space weather event can arise from a combination of solar eruptions.

Ceres Evolution: From Thermodynamic Modeling and Now Dawn Observation

NASA Astrophysics Data System (ADS)

McCord, T. B.; Combe, J. P.; Castillo, J. C.; Raymond, C. A.; De Sanctis, M. C.; Jaumann, R.; Ammannito, E.; Russell, C. T.

2015-12-01

Thermodynamic modeling indicated that Ceres has experienced planetary processes, including extensive melting of its ~25% water and differentiation, (McCord and Sotin, JGR, 2005; Castillo and McCord, Icarus, 2009). Early telescopic studies showed Ceres' surface to be spectrally similar to carboneous-chondrite-like material, i.e., aqueously altered silicates darkened by carbon, with a water-OH-related absorption near 3.06 µm. Later observations improved the spectra and suggested more specific interpretations: Structural water in clay minerals, phyllosilicates, perhaps ammoniated, iron-rich clays, carbonates, brucite, all implying extensive aqueous alteration, perhaps in the presence of CO2. Telescopic observations and thermodynamic models predicted Dawn would find a very different body compared to Vesta (e.g. McCord et al., SSR, 2011), as current Dawn observations are confirming. Ceres' original water ice should have melted early in its evolution, with the resulting differentiation and mineralization strongly affecting Ceres' composition, size and shape over time. The ocean should have become very salty and perhaps may still be liquid in places. The surface composition from telescopes seems to reflect this complex history. The mineralization with repeated mixing of the crust with the early liquid interior and with in-fall from space would create a complex surface that will present an interpretation challenge for Dawn. The Dawn spacecraft is currently collecting observations of Ceres' landforms, elemental and mineralogical/molecular composition and gravity field from orbit. Early results suggest a heavily cratered but distorted and lumpy body with features and composition consistent with internal activity, perhaps recent or current, associated with water and perhaps other volatiles. We will present and interpret the latest Dawn Ceres findings and how they affect our earlier understanding of Ceres evolution from modeling and telescope observations.

Optimization of digital breast tomosynthesis (DBT) acquisition parameters for human observers: effect of reconstruction algorithms

NASA Astrophysics Data System (ADS)

Zeng, Rongping; Badano, Aldo; Myers, Kyle J.

2017-04-01

We showed in our earlier work that the choice of reconstruction methods does not affect the optimization of DBT acquisition parameters (angular span and number of views) using simulated breast phantom images in detecting lesions with a channelized Hotelling observer (CHO). In this work we investigate whether the model-observer based conclusion is valid when using humans to interpret images. We used previously generated DBT breast phantom images and recruited human readers to find the optimal geometry settings associated with two reconstruction algorithms, filtered back projection (FBP) and simultaneous algebraic reconstruction technique (SART). The human reader results show that image quality trends as a function of the acquisition parameters are consistent between FBP and SART reconstructions. The consistent trends confirm that the optimization of DBT system geometry is insensitive to the choice of reconstruction algorithm. The results also show that humans perform better in SART reconstructed images than in FBP reconstructed images. In addition, we applied CHOs with three commonly used channel models, Laguerre-Gauss (LG) channels, square (SQR) channels and sparse difference-of-Gaussian (sDOG) channels. We found that LG channels predict human performance trends better than SQR and sDOG channel models for the task of detecting lesions in tomosynthesis backgrounds. Overall, this work confirms that the choice of reconstruction algorithm is not critical for optimizing DBT system acquisition parameters.

Millimeter observations of the disk around GW Orionis

NASA Astrophysics Data System (ADS)

Fang, M.; Sicilia-Aguilar, A.; Wilner, D.; Wang, Y.; Roccatagliata, V.; Fedele, D.; Wang, J. Z.

2017-07-01

The GW Ori system is a pre-main sequence triple system (GW Ori A/B/C) with companions (GW Ori B/C) at 1 AU and 8 AU, respectively, from the primary (GW Ori A). The primary of the system has a mass of 3.9 M⊙, but shows a spectral type of G8. Thus, GW Ori A could be a precursor of a B star, but it is still at an earlier evolutionary stage than Herbig Be stars. GW Ori provides an ideal target for experiments and observations (being a "blown-up" solar system with a very massive sun and at least two upscaled planets). We present the first spatially resolved millimeter interferometric observations of the disk around the triple pre-main sequence system GW Ori, obtained with the Submillimeter Array, both in continuum and in the 12CO J = 2-1, 13CO J = 2-1, and C18O J = 2-1 lines. These new data reveal a huge, massive, and bright disk in the GW Ori system. The dust continuum emission suggests a disk radius of around 400 AU, but the 12CO J = 2-1 emission shows a much more extended disk with a size around 1300 AU. Owing to the spatial resolution ( 1''), we cannot detect the gap in the disk that is inferred from spectral energy distribution (SED) modeling. We characterize the dust and gas properties in the disk by comparing the observations with the predictions from the disk models with various parameters calculated with a Monte Carlo radiative transfer code RADMC-3D. The disk mass is around0.12 M⊙, and the disk inclination with respect to the line of sight is around 35°. The kinematics in the disk traced by the CO line emission strongly suggest that the circumstellar material in the disk is in Keplerian rotation around GW Ori.Tentatively substantial C18O depletion in gas phase is required to explain the characteristics of the line emission from the disk.

The Anisotropy of the Microwave Background to l=3500: Mosaic Observations with the Cosmic Background Imager

NASA Technical Reports Server (NTRS)

Pearson, T. J.; Mason, B. S.; Readhead, A. C. S.; Shepherd, M. C.; Sievers, J. L.; Udomprasert, P. S.; Cartwright, J. K.; Farmer, A. J.; Padin, S.; Myers, S. T.;

External Validation of the HERNIAscore: An Observational Study.

PubMed

Cherla, Deepa V; Moses, Maya L; Mueck, Krislynn M; Hannon, Craig; Ko, Tien C; Kao, Lillian S; Liang, Mike K

2017-09-01

The HERNIAscore is a ventral incisional hernia (VIH) risk assessment tool that uses only preoperative variables and predictable intraoperative variables. The aim of this study was to validate and modify, if needed, the HERNIAscore in an external dataset. This was a retrospective observational study of all patients undergoing resection for gastrointestinal malignancy from 2011 through 2015 at a safety-net hospital. The primary end point was clinical postoperative VIH. Patients were stratified into low-risk, medium-risk, and high-risk groups based on HERNIAscore. A revised HERNIAscore was calculated with the addition of earlier abdominal operation as a categorical variable. Cox regression of incisional hernia with stratification by risk class was performed. Incidence rates of clinical VIH formation within each risk class were also calculated. Two hundred and forty-seven patents were enrolled. On Cox regression, in addition to the 3 variables of the HERNIAscore (BMI, COPD, and incision length), earlier abdominal operation was also predictive of VIH. The revised HERNIAscore demonstrated improved predictive accuracy for clinical VIH. Although the original HERNIAscore effectively stratified the risk of an incisional radiographic VIH developing, the revised HERNIAscore provided a statistically significant stratification for both clinical and radiographic VIHs in this patient cohort. We have externally validated and improved the HERNIAscore. The revised HERNIAscore uses BMI, incision length, COPD, and earlier abdominal operation to predict risk of postoperative incisional hernia. Future research should assess methods to prevent incisional hernias in moderate-to-high risk patients. Copyright © 2017 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

Galileo support observations of Asteroid 951 Gaspra

NASA Technical Reports Server (NTRS)

Goldader, Jeffrey D.; Tholen, David J.; Cruikshank, Dale P.; Hartmann, William K.

1991-01-01

Observations of 951 Gaspra in support of the Galileo spacecraft encounter are reported. Photometric observations of the asteroid yield a synodic rotational period of 7.042 46 and a slope parameter G of 0.285 + or - 0.005. It is inferred from data obtained on May 18, 1990, that the subearth latitude was higher at that time than it was earlier in the opposition. This places a limit on the possible pole orientation of the asteroid. A slope parameter of 0.25 is proposed on the basis of a comparison of the present result for the slope parameter with that of Barucci et al. (1990). A low-quality 0.8-2.5-micron spectrum of 951 Gaspra suggests a high olivine/pyroxene ratio, which is indicative of a source region in the lower mantle of a differentiated asteroid, and similarities to 8 Flora and particularly 15 Eunomia.

Unveiling Uranus' Clouds: New Observations From Gemini-North NIFS And NIRI

NASA Astrophysics Data System (ADS)

Irwin, Patrick G. J.; Teanby, N. A.; Davis, G. R.; Fletcher, L. N.; Orton, G.; Tice, D.

2010-10-01

Observations of Uranus were made in September 2009 with the Gemini-North telescope in Hawaii, using both the NIFS and NIRI instruments. Adaptive optics were used to achieve a spatial resolution of approximately 0.1 arcsec. NIRI images were recorded with three spectral filters to constrain the overall appearance of the planet: J, H-continuum and CH4(long), and long slit spectra (1.49 to 1.79 microns) were obtained with the slit aligned on Uranus’ central meridian. In addition, the NIFS instrument was used to acquire spectra from other points on the planet, stepping the NIFS 3 x 3 arcsec field of view across Uranus’ disc. These observations were combined to yield complete images of Uranus at 2040 wavelengths between 1.476 and 1.803 microns with a spectral resolution of 5000. The observed spectra along Uranus central meridian were analyzed with the NEMESIS retrieval tool and used to infer the vertical/latitudinal variation in cloud optical depth. We find that the 2009 Gemini data perfectly complement our observations/conclusions from UKIRT/UIST observations made in 2006-2008 and show that the north polar zone at 45N has continued to steadily brighten while that at 45S has continued to fade. The improved spatial resolution of the Gemini observations compared with the non-AO UKIRT/UIST data remove many of the earlier ambiguities inherent in the previous analysis. Overall, Uranus appeared to be less convectively active in 2009 than in the previous 3 years, which suggests that now the equinox (which occurred in 2007) is over the atmosphere is settling back into the quiescent state seen by Voyager 2 in 1986. However, one discrete cloud was captured in the NIFS observations and was estimated to lie at a pressure level of 300-400 mbar.

An XMM-Newton Observation of the Seyfert 1 Galaxy 1H 0419-577 in an Extreme Low State

NASA Technical Reports Server (NTRS)

Pounds, K. A.; Reeves, J. N.; Page, K. L.; OBrien, P. T.

2004-01-01

Previous observations of the luminous Seyfert 1 galaxy 1H 0419-577 have found its X-ray spectrum to range from that of a typical Seyfert 1 with 2-10 keV power law index Gamma approx. 1.9 to a much flatter power law of Gamma approx. 1.5 or less. We report here a new XMM-Newton observation which allows the low state spectrum to be studied in much greater detail than hitherto. We find a very hard spectrum (Gamma approx. 1.0), which exhibits broad features that can be modelled myth the addition of an extreme relativistic Fe K emission line or with partial covering of the underlying continuum by a substantial column density of near-neutral gas. Both the EPIC and RGS data show evidence for strong line emission of OVII and OVIII requiring an extended region of low density photoionised gas in 1H 0419-577. Comparison with an earlier XMM-Newton observation when 1H 0419-577 was 'X-ray bright' indicates the dominant spectral variability occurs via a steep power law component.

Cost-Effectiveness of Earlier Initiation of Antiretroviral Therapy for Uninsured HIV-Infected Adults

PubMed Central

Schackman, Bruce R.; Goldie, Sue J.; Weinstein, Milton C.; Losina, Elena; Zhang, Hong; Freedberg, Kenneth A.

2001-01-01

Objectives. This study was designed to examine the societal cost-effectiveness and the impact on government payers of earlier initiation of antiretroviral therapy for uninsured HIV-infected adults. Methods. A state-transition simulation model of HIV disease was used. Data were derived from the Multicenter AIDS Cohort Study, published randomized trials, and medical care cost estimates for all government payers and for Massachusetts, New York, and Florida. Results. Quality-adjusted life expectancy increased from 7.64 years with therapy initiated at 200 CD4 cells/μL to 8.21 years with therapy initiated at 500 CD4 cells/μL. Initiating therapy at 500 CD4/μL was a more efficient use of resources than initiating therapy at 200 CD4/μL and had an incremental cost-effectiveness ratio of $17 300 per quality-adjusted life-year gained, compared with no therapy. Costs to state payers in the first 5 years ranged from $5500 to $24 900 because of differences among the states in the availability of federal funds for AIDS drug assistance programs. Conclusions. Antiretroviral therapy initiated at 500 CD4 cells/μL is cost-effective from a societal perspective compared with therapy initiated later. States should consider Medicaid waivers to expand access to early therapy. PMID:11527782

The Great Cometary Show

NASA Astrophysics Data System (ADS)

2007-01-01

its high spatial and spectral resolution, it was possible to zoom into the very heart of this very massive star. In this innermost region, the observations are dominated by the extremely dense stellar wind that totally obscures the underlying central star. The AMBER observations show that this dense stellar wind is not spherically symmetric, but exhibits a clearly elongated structure. Overall, the AMBER observations confirm that the extremely high mass loss of Eta Carinae's massive central star is non-spherical and much stronger along the poles than in the equatorial plane. This is in agreement with theoretical models that predict such an enhanced polar mass-loss in the case of rapidly rotating stars. ESO PR Photo 06c/07 ESO PR Photo 06c/07 RS Ophiuchi in Outburst Several papers from this special feature focus on the later stages in a star's life. One looks at the binary system Gamma 2 Velorum, which contains the closest example of a star known as a Wolf-Rayet. A single AMBER observation allowed the astronomers to separate the spectra of the two components, offering new insights in the modeling of Wolf-Rayet stars, but made it also possible to measure the separation between the two stars. This led to a new determination of the distance of the system, showing that previous estimates were incorrect. The observations also revealed information on the region where the winds from the two stars collide. The famous binary system RS Ophiuchi, an example of a recurrent nova, was observed just 5 days after it was discovered to be in outburst on 12 February 2006, an event that has been expected for 21 years. AMBER was able to detect the extension of the expanding nova emission. These observations show a complex geometry and kinematics, far from the simple interpretation of a spherical fireball in extension. AMBER has detected a high velocity jet probably perpendicular to the orbital plane of the binary system, and allowed a precise and careful study of the wind and the shockwave

Map showing surface ruptures associated with the Mammoth Lakes, California, earthquakes of May 1980

USGS Publications Warehouse

Clark, M.M.; Yount, J.C.; Vaughn, P.R.; Zepeda, R.L.

1982-01-01

This map shows surface ruptures associated with the M 6 Mammoth Lakes earthquakes of May 25-27, 1980 (Sherburne, 1980). The ruptures were mapped during USGS field investigations May 28 to June 4 and July 14-19, 1980. The map also includes some of the ruptures recorded by California Division of Mines and Geology investigators May 26-31, June 26-27, and July 7-11, 1980 (Taylor and Bryant, 1980). Because most of the surface ruptures developed in either unconsolidated pumice, alluvium, or till (and many were on slopes of scarps created by earlier faulting), wind, rain and animals quickly erased many of the ruptures. In places, the minimum detectable slip was 3-10 mm. Thus the lines on the map do not record all of the ruptures that formed at the time of the earthquake. Many of the areas were we show gaps between lines on the map probably had cracks originally. 

On the Solar Chromosphere Observed at the LIMB with Hinode

NASA Astrophysics Data System (ADS)

Judge, Philip G.; Carlsson, Mats

2010-08-01

Broadband images in the Ca II H line, from the Broadband Filter Imager (BFI) instrument on the Hinode spacecraft, show emission from spicules emerging from and visible right down to the observed limb. Surprisingly, little absorption of spicule light is seen along their lengths. We present formal solutions to the transfer equation for given (ad hoc) source functions, including a stratified chromosphere from which spicules emanate. The model parameters are broadly compatible with earlier studies of spicules. The visibility of Ca II spicules down to the limb in Hinode data seems to require that spicule emission be Doppler shifted relative to the stratified atmosphere, either by supersonic turbulent or organized spicular motion. The non-spicule component of the chromosphere is almost invisible in the broadband BFI data, but we predict that it will be clearly visible in high spectral resolution data. Broadband Ca II H limb images give the false impression that the chromosphere is dominated by spicules. Our analysis serves as a reminder that the absence of a signature can be as significant as its presence.

Giant-Magnetoresistance(GMR) Siegel KEY FIRST Experimental Discovery Decade-Earlier PRE-``Fert"-``Gruenberg" in Nuc"el"ar ``Super"alloys: Science?;``SEANCE!!!; Ethics?; SHMETHICS!!!

NASA Astrophysics Data System (ADS)

Hoffman, R.; Siegel, E.

2010-03-01

(So MIScalled) ``Fert"-``Grunberg"[PRL(1988;1989)] GMR 2007 physics Nobel/Wolf/Japan-Prizes VS. decade-earlier(1973-1977) KEY FIRST Siegel at:Westin"kl"ouse/PSEG/IAEA/ABB[google:``Martin Ebner"(94-04) in financial media]/Vattenfall/Wallenbergs/nuc"el"ar-DoE Labs[at flickr.com, search on ``Giant- Magnotoresistance''; find: Intl.Conf.Mag.Alloys & Oxides(ICMAO), Haifa(Aug./1977); J.Mag.Mag.Mtls,(JMMM)7,312(1978)``unavailable: not yet scanned''/modified(last R(H) GMR Figs(7;8) deleted!!!) on JMMM/Reed-Elsevier website until 7/29/08 conveniently one- half-year after last (Nobel)award(12/2007); conveniently effectively deleted!!!; google: ``If Leaks Could Kill''; many APS/MRS Mtgs(1970s)<<<1988/1989] decade-earlier GMR: (1978)<<< (1988); 1988-1978 =10 years = one full decadeprecedence!!!] first experimental discovery in (so MIScalled) ``super''alloys [182/82, Hastelloy-X, 600, 690(!!!), Stainless-Steels: ANY/ALL!!!] generic endemic Wigner's[JAP,17,857(1946)]- disease/Ostwald-ripening/spinodal-decomposition/overageing- embrittlement/ thermo-mechanical-INstability!

Stratospheric processes: Observations and interpretation

NASA Technical Reports Server (NTRS)

Brune, William H.; Cox, R. Anthony; Turco, Richard; Brasseur, Guy P.; Matthews, W. Andrew; Zhou, Xiuji; Douglass, Anne; Zander, Rudi J.; Prendez, Margarita; Rodriguez, Jose M.

1991-01-01

Explaining the observed ozone trends discussed in an earlier update and predicting future trends requires an understanding of the stratospheric processes that affect ozone. Stratospheric processes occur on both large and small spatial scales and over both long and short periods of time. Because these diverse processes interact with each other, only in rare cases can individual processes be studied by direct observation. Generally the cause and effect relationships for ozone changes were established by comparisons between observations and model simulations. Increasingly, these comparisons rely on the developing, observed relationships among trace gases and dynamical quantities to initialize and constrain the simulations. The goal of this discussion of stratospheric processes is to describe the causes for the observed ozone trends as they are currently understood. At present, we understand with considerable confidence the stratospheric processes responsible for the Antarctic ozone hole but are only beginning to understand the causes of the ozone trends at middle latitudes. Even though the causes of the ozone trends at middle latitudes were not clearly determined, it is likely that they, just as those over Antarctica, involved chlorine and bromine chemistry that was enhanced by heterogeneous processes. This discussion generally presents only an update of the observations that have occurred for stratospheric processes since the last assessment (World Meteorological Organization (WMO), 1990), and is not a complete review of all the new information about stratospheric processes. It begins with an update of the previous assessment of polar stratospheres (WMO, 1990), followed by a discussion on the possible causes for the ozone trends at middle latitudes and on the effects of bromine and of volcanoes.

IMAGING AND SPECTROSCOPIC OBSERVATIONS OF A TRANSIENT CORONAL LOOP: EVIDENCE FOR THE NON-MAXWELLIAN κ-DISTRIBUTIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dudík, Jaroslav; Mackovjak, Šimon; Dzifčáková, Elena

2015-07-10

We report on the Solar Dynamics Observatory/Atmospheric Imaging Assembly (AIA) and Hinode/EUV Imaging Spectrograph (EIS) observations of a transient coronal loop. The loop brightens up in the same location after the disappearance of an arcade formed during a B8.9-class microflare 3 hr earlier. EIS captures this loop during its brightening phase, as observed in most of the AIA filters. We use the AIA data to study the evolution of the loop, as well as to perform the differential emission measure (DEM) diagnostics as a function of κ. The Fe xi–Fe xiii lines observed by EIS are used to perform themore » diagnostics of electron density and subsequently the diagnostics of κ. Using ratios involving the Fe xi 257.772 Å self-blend, we diagnose κ ≲ 2, i.e., an extremely non-Maxwellian distribution. Using the predicted Fe line intensities derived from the DEMs as a function of κ, we show that, with decreasing κ, all combinations of ratios of line intensities converge to the observed values, confirming the diagnosed κ ≲ 2. These results represent the first positive diagnostics of κ-distributions in the solar corona despite the limitations imposed by calibration uncertainties.« less

Brain potentials show rapid activation of implicit attitudes towards young and old people.

PubMed

van der Lugt, Arie H; Banfield, Jane F; Osinsky, Roman; Münte, Thomas F

2012-01-06

While previous behavioural research suggests that attitudes, for example towards elderly people, may be activated automatically, this type of research does not provide information about the detailed time-course of such processing in the brain. We investigated the impact of age related attitude information in a Go/NoGo association task that paired photographs of elderly or young faces with positive or negative words. Event related brain potentials showed an N200 (NoGo) component, which appeared earlier in runs which required similar responses for congruent stimulus pairings (e.g. respond to pictures of elderly faces or negative words) than for incongruent pairings (e.g. respond to elderly faces or positive words). As information processing leading to a certain attitude must precede differential brain activity according to the congruence of the paired words and faces, we show that this type of information is activated almost immediately following the structural encoding of the face, between 170 and 230 ms after onset of the face. Copyright © 2011. Published by Elsevier B.V.

Comet Halley: The Curtis Schmidts-Isla de Pascua observations

NASA Technical Reports Server (NTRS)

Miller, Freeman D.; Liller, William

1986-01-01

Halley's comet plasma tail disturbances and attendant tail phenomena were observed. Nearly simultaneous exposures with two telescopes serve to correlate information obtained with the two instruments. Photographs of 14 pre-Halley comets taken on 54 nights were examined with a view to cross-interpretation of phenomena seen in Halley with the earlier comets, as recorded on a homogenous collection of plates taken with the same instrument. The tail of Halley was highly active. This contrasts sharply with pre-Halley comets where undisturbed tails are the rule. During March and April, disturbances appeared in the tail of Halley at an average of 1 new distrubance every 3.7 days. It is considered that 10 of the 11 observed disturbances had common characteristics which allow them to be characterized as disconnections.

Analysis and observation of moving domain fronts in a ring of coupled electronic self-oscillators

NASA Astrophysics Data System (ADS)

English, L. Q.; Zampetaki, A.; Kevrekidis, P. G.; Skowronski, K.; Fritz, C. B.; Abdoulkary, Saidou

2017-10-01

In this work, we consider a ring of coupled electronic (Wien-bridge) oscillators from a perspective combining modeling, simulation, and experimental observation. Following up on earlier work characterizing the pairwise interaction of Wien-bridge oscillators by Kuramoto-Sakaguchi phase dynamics, we develop a lattice model for a chain thereof, featuring an exponentially decaying spatial kernel. We find that for certain values of the Sakaguchi parameter α, states of traveling phase-domain fronts involving the coexistence of two clearly separated regions of distinct dynamical behavior, can establish themselves in the ring lattice. Experiments and simulations show that stationary coexistence domains of synchronization only manifest themselves with the introduction of a local impurity; here an incoherent cluster of oscillators can arise reminiscent of the chimera states in a range of systems with homogeneous oscillators and suitable nonlocal interactions between them.

Assessment of risk factors for earlier onset of sporadic Alzheimer's disease dementia.

PubMed

de Oliveira, Fabricio Ferreira; Bertolucci, Paulo Henrique Ferreira; Chen, Elizabeth Suchi; Smith, Marilia Cardoso

2014-01-01

Pharmacological treatment has mild effects for patients with Alzheimer's disease dementia (AD); therefore, the search for modifiable risk factors is an important challenge. Though risk factors for AD are widely recognized, elements that influence the time of dementia onset have not been comprehensively reported. We aimed to investigate which risk factors might be related to the age of onset of AD in a sample of patients with highly variable educational levels, taking into account the Framingham risk scoring as the sole measure of vascular risk. We included 209 consecutive late-onset AD patients to find out which factors among educational levels, coronary heart disease risk estimated by way of Framingham risk scores, history of head trauma or depression, surgical procedures under general anesthesia, family history of neurodegenerative diseases, gender, marital status and APOE haplotypes might be related to the age of dementia onset in this sample of patients with low mean schooling. Mean age of AD onset was 73.38±6.5 years old, unaffected by schooling or family history of neurodegenerative diseases. Patients who were APOE-ε4 carriers, married, or with history of depression, had earlier onset of AD, particularly when they were women. Coronary heart disease risk was marginally significant for later onset of AD. APOE haplotypes, marital status and history of depression were the most important factors to influence the age of AD onset in this sample. While midlife cerebrovascular risk factors may increase incidence of AD, they may lead to later dementia onset when present in late life.

IRAS observations of chromospherically active dwarf stars

NASA Technical Reports Server (NTRS)

Tsikoudi, Vassiliki

1989-01-01

Far-infrared observations of chromospherically active, spotted, and plage stars in the dF7-dk7 spectral range are examined. Most (75 percent) of the stars have detectable 12-micron fluxes, and 50 percent of them have 25-micron emission. The 12-micron luminosity, L(12), is found to be in the range of 1.5-13 x 10 to the 30th ergs/s and to comprise only 0.2-0.5 percent of the star's total luminosity, L(bol). The present work extends to earlier spectral types and higher stellar luminosities the L(12) vs L(bol) relationship noted previously for late-type active dwarfs (K5-M5).

Colorectal cancer occurs earlier in those exposed to tobacco smoke: implications for screening

PubMed Central

Mahoney, Martin C.; Cummings, K. Michael; Michalek, Arthur M.; Reid, Mary E.; Moysich, Kirsten B.; Hyland, Andrew

2011-01-01

Background Colorectal cancer (CRC) is the third most common cancer in the USA. While various lifestyle factors have been shown to alter the risk for colorectal cancer, recommendations for the early detection of CRC are based only on age and family history. Methods This case-only study examined the age at diagnosis of colorectal cancer in subjects exposed to tobacco smoke. Subjects included all patients who attended RPCI between 1957 and 1997, diagnosed with colorectal cancer, and completed an epidemiologic questionnaire. Adjusted linear regression models were calculated for the various smoking exposures. Results Of the 3,540 cases of colorectal cancer, current smokers demonstrated the youngest age of CRC onset (never: 64.2 vs. current: 57.4, P < 0.001) compared to never smokers, followed by recent former smokers. Among never smokers, individuals with past second-hand smoke exposure were diagnosed at a significantly younger age compared to the unexposed. Conclusion This study found that individuals with heavy, long-term tobacco smoke exposure were significantly younger at the time of CRC diagnosis compared to lifelong never smokers. The implication of this finding is that screening for colorectal cancer, which is recommended to begin at age 50 years for persons at average risk should be initiated 5–10 years earlier for persons with a significant lifetime history of exposure to tobacco smoke. PMID:18264728

In-situ observations of a bi-modal ion distribution in the outer coma of comet P/Halley

NASA Technical Reports Server (NTRS)

Thomsen, M. F.; Feldman, W. C.; Wilken, B.; Jockers, K.; Stuedemann, W.

1987-01-01

Observations obtained by the Johnstone Plasma Analyzer on the Giotto fly-by of comet Halley showed a fairly sudden decrease in the count rate of energetic (about 30 KeV) water-group ions inside about 500,000 km from the nucleus. This decrease was accompanied by the appearance of a new water-group ion population at slightly lower energies (less than 10 KeV). Close inspection reveals that this lower-energy peak was also present somewhat earlier in the postshock flow but only became prominent near the sudden transition just described. It is shown that the observed bimodal ion distribution is well explained in terms of the velocity history of the accreting solar wind flow in the outer coma. The decline in count rate of the energetic pick-up distribution is due to a relatively sudden slowing of the bulk flow there and not to a loss of particles. Hence, charge-exchange cooling of the flow is probably not important at these distances from the nucleus. The observations suggest that pitch-angle scattering is fairly efficient at least after the bow shock, but that energy diffusion is probably not very efficient.

Observed ozone response to variations in solar ultraviolet radiation

NASA Technical Reports Server (NTRS)

Gille, J. C.; Smythe, C. M.; Heath, D. F.

1984-01-01

During the winter of 1979, the solar ultraviolet irradiance varied with a period of 13.5 days and an amplitude of 1 percent. The zonal mean ozone values in the tropics varied with the solar irradiance, with an amplitude of 0.25 to 0.60 percent. This observation agrees with earlier calculations, although the response may be overestimated. These results imply changes in ozone at an altitude of 48 kilometers of up to 12 percent over an 11-year solar cycle. Interpretation of ozone changes in the upper stratosphere will require measurements of solar ultraviolet radiation at wavelengths near 200 nanometers.

Titan's Surface Temperatures Maps from Cassini - CIRS Observations

NASA Astrophysics Data System (ADS)

Cottini, Valeria; Nixon, C. A.; Jennings, D. E.; Anderson, C. M.; Samuelson, R. E.; Irwin, P. G. J.; Flasar, F. M.

2009-09-01

The Cassini Composite Infrared Spectrometer (CIRS) observations of Saturn's largest moon, Titan, are providing us with the ability to detect the surface temperature of the planet by studying its outgoing radiance through a spectral window in the thermal infrared at 19 μm (530 cm-1) characterized by low opacity. Since the first acquisitions of CIRS Titan data the instrument has gathered a large amount of spectra covering a wide range of latitudes, longitudes and local times. We retrieve the surface temperature and the atmospheric temperature profile by modeling proper zonally averaged spectra of nadir observations with radiative transfer computations. Our forward model uses the correlated-k approximation for spectral opacity to calculate the emitted radiance, including contributions from collision induced pairs of CH4, N2 and H2, haze, and gaseous emission lines (Irwin et al. 2008). The retrieval method uses a non-linear least-squares optimal estimation technique to iteratively adjust the model parameters to achieve a spectral fit (Rodgers 2000). We show an accurate selection of the wide amount of data available in terms of footprint diameter on the planet and observational conditions, together with the retrieved results. Our results represent formal retrievals of surface brightness temperatures from the Cassini CIRS dataset using a full radiative transfer treatment, and we compare to the earlier findings of Jennings et al. (2009). In future, application of our methodology over wide areas should greatly increase the planet coverage and accuracy of our knowledge of Titan's surface brightness temperature. References: Irwin, P.G.J., et al.: "The NEMESIS planetary atmosphere radiative transfer and retrieval tool" (2008). JQSRT, Vol. 109, pp. 1136-1150, 2008. Rodgers, C. D.: "Inverse Methods For Atmospheric Sounding: Theory and Practice". World Scientific, Singapore, 2000. Jennings, D.E., et al.: "Titan's Surface Brightness Temperatures." Ap. J. L., Vol. 691, pp. L103-L

Reanalysis of the occurrence of back pain among construction workers: modelling for the interdependent effects of heavy physical work, earlier back accidents, and aging.

PubMed

Nurminen, M

1997-11-01

To re-examine the relation between heavy physical work and the occurrence of sciatic pain among construction workers reported previously to be absent in an epidemiological study. METHODS-Poisson log linear regression was used to model for the frequency of sciatic pain among concrete reinforcement workers and maintenance house painters with adjustment for the interactive effects of earlier back accidents and aging that modified the relation. Concrete reinforcement work not only had a direct effect on the frequency of sciatic pain, but it also contributed significantly to the risk indirectly through earlier back accidents. The risk of sciatic pain increased from age 25 to 54 in a different manner for a worker depending on his occupational group and record of back accidents. Epidemiological studies on low back pain need to be analysed with sound methodology. This is important in view of future meta-analyses that will be performed for the purpose of providing guidelines on the prevention of back disorders in heavy physical work.

UV solar irradiance in observations and the NRLSSI and SATIRE-S models

NASA Astrophysics Data System (ADS)

Yeo, K. L.; Ball, W. T.; Krivova, N. A.; Solanki, S. K.; Unruh, Y. C.; Morrill, J.

2015-08-01

Total solar irradiance and UV spectral solar irradiance has been monitored since 1978 through a succession of space missions. This is accompanied by the development of models aimed at replicating solar irradiance by relating the variability to solar magnetic activity. The Naval Research Laboratory Solar Spectral Irradiance (NRLSSI) and Spectral And Total Irradiance REconstruction for the Satellite era (SATIRE-S) models provide the most comprehensive reconstructions of total and spectral solar irradiance over the period of satellite observation currently available. There is persistent controversy between the various measurements and models in terms of the wavelength dependence of the variation over the solar cycle, with repercussions on our understanding of the influence of UV solar irradiance variability on the stratosphere. We review the measurement and modeling of UV solar irradiance variability over the period of satellite observation. The SATIRE-S reconstruction is consistent with spectral solar irradiance observations where they are reliable. It is also supported by an independent, empirical reconstruction of UV spectral solar irradiance based on Upper Atmosphere Research Satellite/Solar Ultraviolet Spectral Irradiance Monitor measurements from an earlier study. The weaker solar cycle variability produced by NRLSSI between 300 and 400 nm is not evident in any available record. We show that although the method employed to construct NRLSSI is principally sound, reconstructed solar cycle variability is detrimentally affected by the uncertainty in the SSI observations it draws upon in the derivation. Based on our findings, we recommend, when choosing between the two models, the use of SATIRE-S for climate studies.

ASCA Observations of W44

NASA Technical Reports Server (NTRS)

Hughes, John P.

1999-01-01

We report the detection, using data from the Advanced Satellite for Cosmology and Astrophysics (ASCA), of a hard X-ray source in the vicinity of the radio pulsar PSR B1853+01, which is located within the supernova remnant (SNR) W44. PSR B1853+01, a 267 ms pulsar, has to date been detected only in the radio band. Previous observations at soft X-ray energies (e.g., with ROSAT HRI) have failed to detect any significant X-ray emission (pulsed or unpulsed) from the pulsar. In addition, no high-energy emission (approx. > 4 keV) has been detected previously from W44. Over the 0.5-4.0 keV band, the ASCA data show soft thermal emission from W44, with a morphology very similar to that observed earlier by Einstein and ROSAT. In the high-energy band (4.0-9.5 keV), the SNR is, for the most part, invisible, although a source coincident with the position of PSR B1853+01 is evident. The observed ASCA spectra are consistent with a power-law origin (photon index approx. 2.3) for the X-ray emission from this source at a flux level (flux density approx. 0.5 micro Jy at I keV) consistent with previous upper limits. The maximum allowed size for the source is determined directiv from the ASCA data (<5 min.), while the minimum size is derived from the nondetection of a point source in the ROSAT HRI data (approx. > 30 sec.). Timing analysis of the hard X-ray source failed to detect pulsations at the pulsar's period. Based on these lines of evidence, we conclude that the new hard source in W44 represents an X-ray synchrotron nebula associated with PSR B1853+01, rather than the beamed output of the pulsar itself. This discoverv adds W44 to the small group of previously known plerionic SNRs This nebula lies at the low end of, but is consistent with, the correlation between X-ray luminosity and pulsar spin-down energy loss found for such objects, lending further support to our interpretation.

Hubble Space Telescope photometry of the central regions of Virgo Cluster elliptical galaxies. 1: Observations, discussion, and conclusions

NASA Technical Reports Server (NTRS)

Jaffe, Walter; Ford, Holland C.; O'Connell, Robert W.; Bosch, Frank C. Van Den; Ferrarese, Laura

1994-01-01

Using the Hubble Space Telescope we have observed at 10 pc resolution the nuclei of a luminosity-limited sample of 14 E and E/SO galaxies in the Virgo Cluster with magnitudes B(sub T) = 9.4 to 13.4. In this paper we present the images, and discuss the results of the detailed analysis of the surface photometry given in two companion papers. We find that the nuclear and near-nuclear morphologies confirm and strengthen the previously recognized dichotomy of 'E' galaxies into 'true' and 'disky' subtypes. The latter, usually classified E4 or later, often show a bright nuclear disk of radius approximately 100 pc. Essentially all early-type galaxies with -18 greater than M(sub B) greater than -20 are disky. Most true E galaxies are classified E4 or earlier. Most galaxies of both types show dust in the nuclear regions, the most remarkable example being a compact dust disk in NGC 4261. Other than dust, no anomalies were detected in the centers of the three galaxies in our sample which show clear kinematic evidence for a decoupled component.

Complementary functions of the two brain hemispheres: comparisons with earlier conceptions and implications for individual and society.

PubMed

Zeier, H

1989-07-01

The concept of different functions for the left and right cerebral hemispheres coincides in an astonishing way with earlier philosophical and psychological work which divided the human mind into two complementary functions without having a neurophysiological explanation. Representative are the ideas of Fichte, Hegel and Jung. The latter postulated the two subsystems Ego and Self and associated the conscious functions of the Ego with the intellect, the capacity for rational thought, and the Self with the mind, which also includes the emotional feelings. For the harmonic development and self-realization of man the functions of both systems in complementary interaction are required. Therefore, the current overaccentuation of the intellect and of progress directed technical-scientific thinking should be corrected by making better use of the much neglected functions of the right hemisphere.

Update on NASA Space Shuttle Earth Observations Photography on the laser videodisc for rapid image access

NASA Technical Reports Server (NTRS)

Lulla, Kamlesh

1994-01-01

There have been many significant improvements in the public access to the Space Shuttle Earth Observations Photography Database. New information is provided for the user community on the recently released videodisc of this database. Topics covered included the following: earlier attempts; our first laser videodisc in 1992; the new laser videodisc in 1994; and electronic database access.

Regge calculus and observations. II. Further applications.

NASA Astrophysics Data System (ADS)

Williams, Ruth M.; Ellis, G. F. R.

1984-11-01

The method, developed in an earlier paper, for tracing geodesies of particles and light rays through Regge calculus space-times, is applied to a number of problems in the Schwarzschild geometry. It is possible to obtain accurate predictions of light bending by taking sufficiently small Regge blocks. Calculations of perihelion precession, Thomas precession, and the distortion of a ball of fluid moving on a geodesic can also show good agreement with the analytic solution. However difficulties arise in obtaining accurate predictions for general orbits in these space-times. Applications to other problems in general relativity are discussed briefly.

Structured education to improve primary-care management of headache: how long do the benefits last? A follow-up observational study.

PubMed

Braschinsky, M; Haldre, S; Kals, M; Arge, M; Saar, B; Niibek, M; Katsarava, Z; Steiner, T J

2018-03-01

Our earlier study showed that structured education of general practitioners (GPs) improved their practice in headache management. Here the duration of this effect was assessed. In a follow-up observational study in southern Estonia, subjects were the same six GPs as previously, managing patients presenting with headache as the main complaint. Data reflecting their practice were collected prospectively during a 1-year period commencing 2 years after the educational intervention. The primary outcome measure was referral rate (RR) to neurological services. Comparisons were made with baseline and post-intervention data from the earlier study. In 366 patients consulting during the follow-up period, the RR was 19.9%, lower than at baseline (39.5%; P < 0.0001) or post-intervention (34.7%; P < 0.0001). The RR was diagnosis-dependent: the biggest decline was for migraine. Use of headache diagnostic terms showed changes generally favouring specific terminology. In particular, the proportion of patients given migraine diagnoses greatly increased whilst use of the inappropriate M79.1 (Pericranial) myalgia almost disappeared. Requests for investigations, which had fallen from 26% (of patients seen) at baseline to 4% post-intervention, resurged to 23% (mostly laboratory investigations; requests for X-rays continued to dwindle). Initiation of treatment by the GPs remained at the post-intervention level of just over 80% (up from baseline 58%). Improvements in GPs' practice after a structured educational programme mostly last for ≥3 years, some showing further betterment. A few measures suggest the beginnings of a decline towards baseline levels. This policy-informing evidence for continuing medical education indicates that the educational programme needs repeating every 2-3 years. © 2017 EAN.

Earlier response assessment in invasive aspergillosis based on the kinetics of serum Aspergillus galactomannan: proposal for a new definition.

PubMed

Nouér, Simone A; Nucci, Marcio; Kumar, Naveen Sanath; Grazziutti, Monica; Barlogie, Bart; Anaissie, Elias

2011-10-01

Current criteria for assessing treatment response of invasive aspergillosis (IA) rely on nonspecific subjective parameters. We hypothesized that an Aspergillus-specific response definition based on the kinetics of serum Aspergillus galactomannan index (GMI) would provide earlier and more objective response assessment. We compared the 6-week European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) response criteria with GMI-based response among 115 cancer patients with IA. Success according to GMI required survival with repeatedly negative GMI for ≥2 weeks. Time to response and agreement between the 2 definitions were the study endpoints. Success according to EORTC/MSG and GMI criteria was observed in 73 patients (63%) and 83 patients (72%), respectively. The GMI-based response was determined at a median of 21 days after treatment initiation (range, 15-41 days), 3 weeks before the EORTC/MSG time point, in 72 (87%) of 83 responders. Agreement between definitions was shown in all 32 nonresponders and in 73 of the 83 responders (91% overall), with an excellent κ correlation coefficient of 0.819. Among 10 patients with discordant response (EORTC/MSG failure, GMI success), 1 is alive without IA 3 years after diagnosis; for the other, aspergillosis could not be detected at autopsy. The presence of other life-threatening complications in the remaining 8 patients indicates that IA had resolved. The Aspergillus-specific GMI-based criteria compare favorably to current response definitions for IA and significantly shorten time to response assessment. These criteria rely on a simple, reproducible, objective, and Aspergillus-specific test and should serve as the primary endpoint in trials of IA.

Infliximab for uveitis of Behçet's syndrome: a trend for earlier initiation.

PubMed

Guzelant, Gul; Ucar, Didar; Esatoglu, Sinem Nihal; Hatemi, Gulen; Ozyazgan, Yilmaz; Yurdakul, Sebahattin; Seyahi, Emire; Yazici, Hasan; Hamuryudan, Vedat

2017-01-01

The prognosis of uveitis in Behçet's syndrome (BS) has improved over decades. Whether this is related to the use of more aggressive management strategies is not known. This is a retrospective study of BS patients who received infliximab (IFX) for refractory eye disease between 2003-2015. The patients were divided into two groups according to the date of onset of in IFX treatment as before and after 2013. We compared the two groups in terms of disease characteristics at the onset of IFX treatment and response to treatment. There were 43 patients in the old and 14 patients in the new group. The duration of uveitis and previous immunosuppressive treatment before the initiation of IFX were significantly shorter in the new group compared to the old group (p=0.043 and p=0.028, respectively). The baseline visual acuity (VA) at the initiation of IFX was better in the new group, but this was only significant for the left eye. Treatment with IFX was effective in both groups in preserving VA and this was more pronounced in the new group. Attack frequency under IFX was significantly lower in the new group (p<0.001). IFX seems to be initiated earlier and also in less severe cases during the course of BS uveitis than before. Despite the few numbers of patients and relatively short duration of follow-up, our results give a hint that this change has improved the outcome.

DE 1 and Viking observations associated with electron conical distributions

NASA Technical Reports Server (NTRS)

Menietti, J. D.; Weimer, D. R.; Andre, M.; Eliasson, L.

1994-01-01

Data from the electron detectors on board the Swedish Viking satellite launched during a period of low solar activity and from the Dynamic Explorer (DE) 1 satellite launched during active solar coditions have been examined for the occurrence and location of electron conical distributions and several conclusions can be drawn. First, we note that most of the best examples of electron conics observed by the V-3 experiment onboard Viking occurred in the afternoon sector in the range of magneitc local time 14 hours less than Magnetic Local Time (MLT) less than 18 hours, at midaltitudes in the range 10,000 km less than h less than 13,500 km, with few occurring in the nightside auroral region, a region poorly sampled at altitudes greater than 5000 km. For the Viking data there is an association of electron conics with upper hybrid waves. DE 1 observations made by the high-altitude plasma instrument (HAPI) indicate that electron conics were observed in the midmorning sector and the late evening sector, and as has been reported earlier, the correlation with upper hybird waves was good. The HAPI did not sample the afternoon sector. The electon conics observed on both satellites occurred in the presence of at least a modest (several kilovolts) potential difference beneath the satellite with a maximum energy that was usually, but not always, equal to or greater than the maximum energy of the electron conics. Two independent sets of observations by DE 1 suggest two distinct production mechanisms for electron conics. Examiniation of DE 1 electric field measurements from the plasma wave instrument during the observation of electron conics show simultaneous parallel oscillations in the frequency range of 0.2 Hz less than f less than 0.5 Hz during one and perhaps two of four events examined, and upper hybrid waves were observed on all four events. In addition, recent observations of '90-deg' electron conics associated with auroral kilometric radiation source regions suggest a

Impact of DYNAMO observations on NASA GEOS-5 reanalyses and the representation of MJO initiation

NASA Astrophysics Data System (ADS)

Achuthavarier, D.; Wang, H.; Schubert, S. D.; Sienkiewicz, M.

2017-01-01

This study examines the impact of the Dynamics of the Madden-Julian Oscillation (DYNAMO) campaign in situ observations on NASA Goddard Earth Observing System version 5 (GEOS-5) reanalyses and the improvements gained thereby in the representation of the Madden-Julian Oscillation (MJO) initiation processes. To this end, we produced a global, high-resolution (1/4° spatially) reanalysis that assimilates the level-4, quality-controlled DYNAMO upper air soundings from about 87 stations in the equatorial Indian Ocean region along with a companion data-denied control reanalysis. The DYNAMO reanalysis produces a more realistic vertical structure of the temperature and moisture in the central tropical Indian Ocean by correcting the model biases, namely, the cold and dry biases in the lower troposphere and warm bias in the upper troposphere. The reanalysis horizontal winds are substantially improved, in that, the westerly acceleration and vertical shear of the zonal wind are enhanced. The DYNAMO reanalysis shows enhanced low-level diabatic heating, moisture anomalies and vertical velocity during the MJO initiation. Due to the warmer lower troposphere, the deep convection is invigorated, which is evident in convective cloud fraction. The GEOS-5 atmospheric general circulation model (AGCM) employed in the reanalysis is overall successful in assimilating the additional DYNAMO observations, except for an erroneous model response for medium rain rates, between 700 and 600 hPa, reminiscent of a bias in earlier versions of the AGCM. The moist heating profile shows a sharp decrease there due to the excessive convective rain re-evaporation, which is partly offset by the temperature increment produced by the analysis.

Hα observations with DEFPOS

NASA Astrophysics Data System (ADS)

Sahan, M.

2011-02-01

A 7.5 cm, dual étalon Fabry-Pérot spectrometer called DEFPOS has been set up at Coudé focus of 150 cm RTT150 telescope at TUBITAK National Observatory (TUG, Antalya, Turkey) to investigate the physical properties of Diffuse Ionized Gas (DIG) in our Galaxy. The spectrometer, having a 4 arcmin circular field of view over a 200 km s-1 (4.4 Å) spectral window near Hα, has been used to observe H II regions and Planetary Nebulae (PNe) since May 2007 (Sahan et al. 2009). Early observations have been analyzed and physical and kinematic properties such as the intensity, the line width, and the LSR velocity are presented here. These values are compared with earlier results from different studies. In this study, I discuss some results obtained by DEFPOS, including two H II regions (Sh2-156, Sh2-157), and two PNe (NGC 1360, and NGC 6826). The Intensities, the radial velocities and the line widths of the Hα emission line vary from 101.4R to 149.97R (1 Rayleigh =106/4π photons cm-2 sr-1 s-1 = 2.41×10-7 erg cm-2 s-1 sr-1 at Hα), -41.19 km s-1 to +8.34 km s-1, and 39.55 km s-1 to 58.23 km s-1, respectively.

Copernicus Earth observation programme

NASA Astrophysics Data System (ADS)

Žlebir, Silvo

European Earth observation program Copernicus is an EU-wide programme that integrates satellite data, in-situ data and modeling to provide user-focused information services to support policymakers, researchers, businesses and citizens. Land monitoring service and Emergency service are fully operational already, Atmosphere monitoring service and Marine environment monitoring service are preoperational and will become fully operational in the following year, while Climate change service and Security service are in an earlier development phase. New series of a number of dedicated satellite missions will be launched in the following years, operated by the European Space Agency and EUMETSAT, starting with Sentinel 1A satellite early this year. Ground based, air-borne and sea-borne in-situ data are provided by different international networks and organizations, EU member states networks etc. European Union is devoting a particular attention to secure a sustainable long-term operational provision of the services. Copernicus is also stated as a European Union’s most important contribution to Global Earth Observation System of Systems (GEOSS). The status and the recent development of the Copernicus programme will be presented, together with its future perspective. As Copernicus services have already demonstrated their usability and effectiveness, some interesting cases of their deployment will be presented. Copernicus free and open data policy, supported by a recently adopted EU legislative act, will also be presented.

X-Ray Micro-CT Observations of Hydrate Pore Habit and Lattice Boltzmann Simulations on Permeability Evolution in Hydrate Bearing Sediments (HBS)

NASA Astrophysics Data System (ADS)

Chen, X.; Espinoza, N.; Verma, R.; Prodanovic, M.

2017-12-01

We use X-ray micro-computed tomography (μCT) to observe xenon hydrate growth. During xenon hydrate formation in a single pore and a sandpack, we observe heterogeneous (patchy) hydrate distribution at both pore (10 μm) and core scales (10 cm). These results present similarities with earlier observations on naturally occurring and synthetic hydrate-bearing sediment (HBS). Based on image analyses of xenon hydrate in the single pore, we find that, under the quasi-isothermal condition, the xenon volumetric growth rate versus overpressurization curve fits an Arrhenius type equation. Using the μCT images of HBS, we are able to calculate the permeability of HBS using a lattice Boltzmann method. We find the reduced permeability versus hydrate saturation curve fits a simple Corey-type model as suggested by earlier studies. However, patchy distribution of hydrate does not permit a straightforward interpretation of the saturation exponent. This work provides fundamental observations of hydrate growth and pore habit in sediments and how hydrate habit affects the hydraulic conductivity of HBS. Further implications can be extended to the strength, seismic velocities and electrical properties of HBS.

COS Observations of SN1987A

NASA Astrophysics Data System (ADS)

McCray, Richard; France, K.; Kirshner, R. P.; SAINTS Collaboration

2012-01-01

We present the most sensitive ultraviolet observations of Supernova 1987A to date. Imaging spectroscopy from the Hubble Space Telescope-Cosmic Origins Spectrograph shows many narrow (v - 300 km/s) emission lines from the circumstellar ring, broad (v - 10 - 20 × 103 km/s) emission lines from the reverse shock, and ultraviolet continuum emission. The high signal-to-noise (> 40 per resolution element) broad Ly α emission is excited by soft X-ray and EUV heating of mostly neutral gas in the circumstellar ring and outer supernova debris. The ultraviolet continuum at - > 1350 A can be explained by H I 2-photon (2s 2S1/2 - 1s 2S1/2) emission from the same region. We confirm our earlier, tentative detection of N V -1240 emission from the reverse shock and we present the first detections of broad He II 1640, C IV -1550, and N IV] 1486 emission lines from the reverse shock. The helium abundance in the high velocity material is He/H = 0.14 +/- 0.06. The N V/H line ratio requires partial ion-electron equilibration (Te/Tp - 0.14 - 0.35). We find that the N/C abundance ratio in the gas crossing the reverse shock is significantly higher than that in the circumstellar ring, a result we attribute to continued CNO processing in the supernova progenitor subsequent to the expulsion of the circumstellar ring.

The Fischa-Dagnitz spring, Southern Vienna Basin: a multi tracer time series study re-assessing earlier conceptual assumptions.

NASA Astrophysics Data System (ADS)

Suckow, Axel; Gerber, Christoph; Kralik, Martin; Sültenfuss, Jürgen; Purtschert, Roland

2013-04-01

The gravel aquifer of the Southern Vienna Basin is a very important backup drinking water resource for the city of Vienna. A discharge location, the Fischa-Dagnitz spring in the Southern Vienna Basin, Austria, was re-investigated in 2011, five years after the gas exchange tracer test published in (Stolp et al., 2010), and sampled for stable isotopes 18O/2H, tritium, 3He, SF6 and 85Kr (Gerber et al., 2012). Additionally, new tritium time series data (Davis et al., 1967), previously not considered in Stolp et al. (2010), were included. These show a higher and earlier tritium peak of >300 TU in 1965 in the discharge of the Fischa-Dagnitz spring as compared to 221 TU in 1972 considered in Stolp et al. (2010). The new 3He, SF6 and 85Kr gas tracer data from 2011 confirm the earlier finding for 3He of Stolp et al. (2010) and indicate a more recent equilibration with the atmosphere than the water bound tracers 18O, 2H and tritium. A new modelling attempt using the Lumpy code (Suckow, 2012) confirmed the discrepancy between the tritium data and the gaseous tracers 3He, SF6 and 85Kr. No steady-state combination of local recharge (represented by an exponential model) and Schwarza river infiltration flowing through the gravel aquifer (represented by a parallel dispersion model) can equally well explain both the tritium time series and the gas tracer results. A revised conceptual model proposes that a pinching of the aquifer at unconformities in the gravel body or a fault zone known in the gravel body forces groundwater along the flow path closer to the surface and exposes it to the atmosphere. This would tend to reset the "dating" clock for the gaseous tracers 3He, SF6 and 85Kr, which can equilibrate quickly with the atmosphere, but not for tritium, which marks the transport behaviour of the water itself. These findings are of importance also for other multi-tracer assessments of groundwater movement in phreatic aquifer systems. References: Davis, G.H., Payne, B.R., Dincer, T

Ooishi's Observation: Viewed in the Context of Jet Stream Discovery.

NASA Astrophysics Data System (ADS)

Lewis, John M.

2003-03-01

Although aircraft encounters with strong westerly winds during World War II provided the stimulus for postwar research on the jet stream, Wasaburo Ooishi observed these winds in the 1920s. Ooishi's work is reviewed in the context of earlier work in upperair observation and postwar work on the jet stream. An effort is made to reconstruct Ooishi's path to the directorship of Japan's first upper-air observatory by reliance on historical studies and memoirs from the Central Meteorological Observatory.Archival records from Japan's Aerological Observatory have been used to document Ooishi's upperair observations. The first official report from the observatory (written in 1926 and in the auxiliary language of Esperanto) assumes a central role in the study. In this report, data are stratified by season and used to produce the mean seasonal wind profiles. The profile for winter gives the first known evidence of the persistent strong westerlies over Japan that would later become known as the jet stream.

Revisiting the stellar velocity ellipsoid-Hubble-type relation: observations versus simulations

NASA Astrophysics Data System (ADS)

Pinna, F.; Falcón-Barroso, J.; Martig, M.; Martínez-Valpuesta, I.; Méndez-Abreu, J.; van de Ven, G.; Leaman, R.; Lyubenova, M.

2018-04-01

The stellar velocity ellipsoid (SVE) in galaxies can provide important information on the processes that participate in the dynamical heating of their disc components (e.g. giant molecular clouds, mergers, spiral density waves, and bars). Earlier findings suggested a strong relation between the shape of the disc SVE and Hubble type, with later-type galaxies displaying more anisotropic ellipsoids and early types being more isotropic. In this paper, we revisit the strength of this relation using an exhaustive compilation of observational results from the literature on this issue. We find no clear correlation between the shape of the disc SVE and morphological type, and show that galaxies with the same Hubble type display a wide range of vertical-to-radial velocity dispersion ratios. The points are distributed around a mean value and scatter of σz/σR = 0.7 ± 0.2. With the aid of numerical simulations, we argue that different mechanisms might influence the shape of the SVE in the same manner and that the same process (e.g. mergers) does not have the same impact in all the galaxies. The complexity of the observational picture is confirmed by these simulations, which suggest that the vertical-to-radial axis ratio of the SVE is not a good indicator of the main source of disc heating. Our analysis of those simulations also indicates that the observed shape of the disc SVE may be affected by several processes simultaneously and that the signatures of some of them (e.g. mergers) fade over time.

HerMES: point source catalogues from Herschel-SPIRE observations II

NASA Astrophysics Data System (ADS)

Wang, L.; Viero, M.; Clarke, C.; Bock, J.; Buat, V.; Conley, A.; Farrah, D.; Guo, K.; Heinis, S.; Magdis, G.; Marchetti, L.; Marsden, G.; Norberg, P.; Oliver, S. J.; Page, M. J.; Roehlly, Y.; Roseboom, I. G.; Schulz, B.; Smith, A. J.; Vaccari, M.; Zemcov, M.

2014-11-01

The Herschel Multi-tiered Extragalactic Survey (HerMES) is the largest Guaranteed Time Key Programme on the Herschel Space Observatory. With a wedding cake survey strategy, it consists of nested fields with varying depth and area totalling ˜380 deg2. In this paper, we present deep point source catalogues extracted from Herschel-Spectral and Photometric Imaging Receiver (SPIRE) observations of all HerMES fields, except for the later addition of the 270 deg2 HerMES Large-Mode Survey (HeLMS) field. These catalogues constitute the second Data Release (DR2) made in 2013 October. A sub-set of these catalogues, which consists of bright sources extracted from Herschel-SPIRE observations completed by 2010 May 1 (covering ˜74 deg2) were released earlier in the first extensive data release in 2012 March. Two different methods are used to generate the point source catalogues, the SUSSEXTRACTOR point source extractor used in two earlier data releases (EDR and EDR2) and a new source detection and photometry method. The latter combines an iterative source detection algorithm, STARFINDER, and a De-blended SPIRE Photometry algorithm. We use end-to-end Herschel-SPIRE simulations with realistic number counts and clustering properties to characterize basic properties of the point source catalogues, such as the completeness, reliability, photometric and positional accuracy. Over 500 000 catalogue entries in HerMES fields (except HeLMS) are released to the public through the HeDAM (Herschel Database in Marseille) website (http://hedam.lam.fr/HerMES).

2011 Annual Survey of Journalism and Mass Communication Enrollments: Enrollments Decline, Reversing the Increase of a Year Earlier, and Suggesting Slow Growth for Future

ERIC Educational Resources Information Center

Becker, Lee B.; Vlad, Tudor; Kalpen, Konrad

2012-01-01

Enrollments in journalism and mass communication programs declined in the autumn of 2011, compared to a year earlier. Enrollments were down slightly at the senior and junior levels and substantially at the freshman level. Enrollment increased at the sophomore level. The majority of administrators say they have made curricular changes in the past…

Specific yield - laboratory experiments showing the effect of time on column drainage

USGS Publications Warehouse

Prill, Robert C.; Johnson, A.I.; Morris, Donald Arthur

1965-01-01

The increasing use of ground water from many major aquifers in the United States has required a more thorough understanding of gravity drainage, or specific yield. This report describes one phase of specific yield research by the U.S. Geological Survey's Hydrologic Laboratory in cooperation with the California Department of Water Resources. An earlier phase of the research concentrated on the final distribution of moisture retained after drainage of saturated columns of porous media. This report presents the phase that concentrated on the distribution of moisture retained in similar columns after drainage for various periods of time. Five columns, about 4 cm in diameter by 170 cm long, were packed with homogenous sand of very fine, medium, and coarse sizes, and one column was packed with alternating layers of coarse and medium sand. The very fine materials were more uniform in size range than were the medium materials. As the saturated columns drained, tensiometers installed throughout the length recorded changes in moisture tension. The relation of tension to moisture content, determined for each of the materials, was then used to convert the tension readings to moisture content. Data were then available on the distribution of retained moisture for different periods of drainage from 1 to 148 hours. Data also are presented on the final distribution of moisture content by weight and volume and on the degree of saturation. The final zone of capillary saturation was approximately 12 cm for coarse sand, 13 cm for medium sand, and 52 cm for very fine sand. The data showed these zones were 92 to 100 percent saturated. Most of the outflow from the columns occurred in the earlier hours of drainage--90 percent in 1 hour for the coarse materials, 50 percent for the medium, and 60 percent for the very fine. Although the largest percentage of the specific yield was reached during the early hours of .drainage, this study amply demonstrates that a very long time would be

A Computational Observer For Performing Contrast-Detail Analysis Of Ultrasound Images

NASA Astrophysics Data System (ADS)

Lopez, H.; Loew, M. H.

1988-06-01

Contrast-Detail (C/D) analysis allows the quantitative determination of an imaging system's ability to display a range of varying-size targets as a function of contrast. Using this technique, a contrast-detail plot is obtained which can, in theory, be used to compare image quality from one imaging system to another. The C/D plot, however, is usually obtained by using data from human observer readings. We have shown earlier(7) that the performance of human observers in the task of threshold detection of simulated lesions embedded in random ultrasound noise is highly inaccurate and non-reproducible for untrained observers. We present an objective, computational method for the determination of the C/D curve for ultrasound images. This method utilizes digital images of the C/D phantom developed at CDRH, and lesion-detection algorithms that simulate the Bayesian approach using the likelihood function for an ideal observer. We present the results of this method, and discuss the relationship to the human observer and to the comparability of image quality between systems.

Urban Observation and Sentiment in James Parkinson’s Essay on the Shaking Palsy (1817)

PubMed Central

Hurwitz, Brian

2014-01-01

James Parkinson’s Essay on the Shaking Palsy (1817) has long been considered the foundational text of the disease which now bears the author’s name. This paper shows how the Essay radically re-formulated a diverse array of human dysmobilities as a “species” of disease. Parkinson incorporated medical observation with a clear focus on patient experience and subjectivity in a deeply affecting narrative, fusing clinical and urban case-descriptions within the genre of a sentimental natural history. His detailed, diagnostic portrayal of the malady recast earlier descriptions of trembling, posture and gait disorder within a new narrative order, simultaneously recruiting reader involvement to the plight of sufferers. Hardly any clinical examination as we know it today undergirds what remains an exemplary account of disciplined medical witness. The Essay demonstrates the potential of case construction and powerful, sympathetic case writing to transform clinical understanding of a complex medical condition of long duration. PMID:25055707

Coordinated observations of interacting peculiar red giant binaries, 2

NASA Technical Reports Server (NTRS)

Ake, T.

1995-01-01

IUE and H alpha observations continued on a two-year program to monitor the UV variability of three interacting peculiar red giant (PRG) binaries, HD 59643 (C6,s), HD 35155 (S3/2), and HR 1105 (S3.5/2.5). All of these systems were suspected to involve accretion of material from the PRG to a white-dwarf secondary, based mainly on previous IUE investigations. They were primary candidates from earlier surveys of PRG's to test the hypothesis that the Tc-poor PRG's are formed as a result of mass transfer from a secondary component rather than from internal thermal pulsing while on the asymptotic red giant branch.

Coordinated observations of interacting peculiar red giant binaries, 1

NASA Technical Reports Server (NTRS)

Ake, T.

1995-01-01

IUE Observations were begun for a two-year program to monitor the UV variability of three interacting peculiar red giant (PRG) binaries, HD 59643 (C6,s) HD 35155 (S3/2), and HR 1105 (S3.5/2.5). All of these systems were suspected to involve accretion of material from the PRG to a white-dwarf secondary, based mainly on previous IUE investigations. From our earlier surveys of PRG's, they were primary candidates to test the hypothesis that Tc-poor PRG's are formed as a result of mass transfer from a secondary component rather than from internal thermal pulsing while on the asymptotic red giant branch.

Solar System Observations with Spitzer Space Telescope: Preliminary Results

NASA Technical Reports Server (NTRS)

Cruikshank, Dale P.

2005-01-01

The programs of observations of Solar System bodies conducted in the first year of the operation of the Spitzer Space Telescope as part of the Guaranteed Observing Time allocations are described. Initial results include the determination of the albedos of a number of Kuiper Belt objects and Centaurs from observations of their flux densities at 24 and 70 microns, and the detection of emission bands in the spectra of several distant asteroids (Trojans) around 10 and 25 microns. The 10 Kuiper Belt objects observed to date have albedos in the range 0.08 - 0.15, significantly higher than the earlier estimated 0.04. An additional KBO [(55565) 2002 AW(sub l97)] has an albedo of 0.17 plus or minus 0.03. The emission bands in the asteroid spectra are indicative of silicates, but specific minerals have not yet been identified. The Centaur/comet 29P/Schwassmann-Wachmann 1 has a nucleus surface albedo of 0.025 plus or minus 0.01, and its dust production rate was calculated from the properties of the coma. Several other investigations are in progress as the incoming data are processed and analyzed.

Observations and initial modeling of lava-SO2 interactions at Prometheus, Io

NASA Astrophysics Data System (ADS)

Milazzo, M. P.; Keszthelyi, L. P.; McEwen, A. S.

2001-12-01

We present observations and initial modeling of the lava-SO2 interactions at the flow fronts in the Prometheus region of Io. Recent high-resolution observations of Prometheus reveal a compound flow field with many active flow lobes. Many of the flow lobes are associated with bright streaks of what is interpreted to be volatilized and recondensed SO2 radiating away from the hot lava. Lower-resolution color data show diffuse blue to violet areas, also near the active flow front, perhaps from active venting of SO2. Not clearly visible in any of the images is a single source vent for the active plume. While the size of the proposed vent is probably near the limit of the resolution, we expected to see radial or concentric albedo patterns or other evidence for gas and entrained particles above the flow field. The lack of an obvious plume vent, earlier suggestions that the Prometheus-type plumes may originate from the advancing flow lobes, and the high-resolution images showing evidence for large-scale volatilization of the SO2-rich substrate at Prometheus encouraged us to develop a model to quantify the heat transfer between a basaltic lava flow and a substrate of SO2 snow. We calculate that the vaporization rate of SO2 snow is 2.5×10-6ms-1 per unit area. Using an estimated 5 m2s-1 lava coverage rate (from change detection images), we show that the gas production rate of SO2 at the flow fronts is enough to produce a resurfacing rate of ~0.24 cm yr-1 at the annulus of Prometheus. This is much less than other estimates of resurfacing by the Prometheus plume. While not easily explaining the main Prometheus plume, our model readily accounts for the bright streaks.

The Chinese Visible Human (CVH) datasets incorporate technical and imaging advances on earlier digital humans

PubMed Central

Zhang, Shao-Xiang; Heng, Pheng-Ann; Liu, Zheng-Jin; Tan, Li-Wen; Qiu, Ming-Guo; Li, Qi-Yu; Liao, Rong-Xia; Li, Kai; Cui, Gao-Yu; Guo, Yan-Li; Yang, Xiao-Ping; Liu, Guang-Jiu; Shan, Jing-Lu; Liu, Ji-Jun; Zhang, Wei-Guo; Chen, Xian-Hong; Chen, Jin-Hua; Wang, Jian; Chen, Wei; Lu, Ming; You, Jian; Pang, Xue-Li; Xiao, Hong; Xie, Yong-Ming; Cheng, Jack Chun-Yiu

2004-01-01

We report the availability of a digitized Chinese male and a digitzed Chinese female typical of the population and with no obvious abnormalities. The embalming and milling procedures incorporate three technical improvements over earlier digitized cadavers. Vascular perfusion with coloured gelatin was performed to facilitate blood vessel identification. Embalmed cadavers were embedded in gelatin and cryosectioned whole so as to avoid section loss resulting from cutting the body into smaller pieces. Milling performed at −25 °C prevented small structures (e.g. teeth, concha nasalis and articular cartilage) from falling off from the milling surface. The male image set (.tiff images each of 36 Mb) has a section resolution of 3072 × 2048 pixels (∼170 μm, the accompanying magnetic resonance imaging and computer tomography data have a resolution of 512 × 512, i.e. ∼440 μm). The Chinese Visible Human male and female datasets are available at http://www.chinesevisiblehuman.com. (The male is 90.65 Gb and female 131.04 Gb). MPEG videos of direct records of real-time volume rendering are at: http://www.cse.cuhk.edu.hk/~crc PMID:15032906

On the Diurnal Periodicity of Representative Earthquakes in Greece: Comparison of Data from Different Observation Systems

NASA Astrophysics Data System (ADS)

Desherevskii, A. V.; Sidorin, A. Ya.

2017-12-01

Due to the initiation of the Hellenic Unified Seismic Network (HUSN) in late 2007, the quality of observation significantly improved by 2011. For example, the representative magnitude level considerably has decreased and the number of annually recorded events has increased. The new observational system highly expanded the possibilities for studying regularities in seismicity. In view of this, the authors revisited their studies of the diurnal periodicity of representative earthquakes in Greece that was revealed earlier in the earthquake catalog before 2011. We use 18 samples of earthquakes of different magnitudes taken from the catalog of Greek earthquakes from 2011 to June 2016 to derive a series of the number of earthquakes for each of them and calculate its average diurnal course. To increase the reliability of the results, we compared the data for two regions. With a high degree of statistical significance, we have obtained that no diurnal periodicity can be found for strongly representative earthquakes. This finding differs from the estimates obtained earlier from an analysis of the catalog of earthquakes at the same area for 1995-2004 and 2005-2010, i.e., before the initiation of the Hellenic Unified Seismic Network. The new results are consistent with the hypothesis of noise discrimination (observational selection) explaining the cause of the diurnal variation of earthquakes with different sensitivity of the seismic network in daytime and nighttime periods.

Suzaku observation of IGR J16318-4848

NASA Technical Reports Server (NTRS)

Barragan, Laura; Wilms, Joern; Pottschmidt, Katja; Nowak, Michael A.; Kreykenbohm, Ingo; Walter, Roland; Tomsick, John A.

2009-01-01

We report on the first Suzaku observation of IGR J16318-4848, the most extreme example of a new group of highly absorbed X-ray binaries that have recently been discovered by the International Gamma-Ray Astrophysics Laboratory (INTEGRAL). The Suzaku observation was carried out between 2006 August 14 and 17, with a net exposure time of 97 ks. The average X-ray spectrum of the source can be well described (chi-square (sub red)= 0.99) with a continuum model typical for neutron stars i.e., a strongly absorbed power law continuum with a photon index of 0.676(42) and an exponential cutoff at 20.5(6) keY. The absorbing column is N(sub H) = 1.95(3) X 10(exp 24)/square cm. Consistent with earlier work, strong fluorescent emission lines of Fe K-alpha, Fe K-beta, and Ni K-alpha are observed. Despite the large N(sub H), no Compton shoulder is seen in the lines, arguing for a non-spherical and inhomogeneous absorber. Seen at an average 5-60 keV absorbed flux of 3.4 x 10(exp -10) erg/square cm/second, the source exhibits significant variability on timescales of hours.

Search for an X-ray identification of a strong gamma-ray source. [sas-3 observations

NASA Technical Reports Server (NTRS)

Lamb, R. C.

1979-01-01

X-rays from Cygnus X-3 were observed during early 1978 with the detectors of the SAS-3 satellite. These observations in conjunction with earlier UHURU and ANS data indicate that the 4.8 hr period of Cygnus X-3 is increasing at the rate of P/P = (5/1 plus or minus 1.3) x 10 to the minus 6 power/1 yr. The sign and magnitude for this change are incompatible with a rotation model for the period and are in reasonable agreement with model predictions for orbital changes associated with mass loss and transfer in a binary system.

Observable characteristics associated with alcohol intoxication within licensed entertainment venues in Australia.

PubMed

Coomber, Kerri; Pennay, Amy; Droste, Nicolas; Mayshak, Richelle; Martino, Florentine; Bowe, Steven J; Miller, Peter G

2016-10-01

The aim of the current study was to assess correlates of intoxication in licensed venues in Australia. Covert observations of licensed venues and venue patron in night-time entertainment districts of five Australian cities were conducted. In total, 828 unique cross-sectional observations were completed across 62 bars, nightclubs, and large mainstream pubs. Venues were selected from the main entertainment district of smaller cities and the busiest entertainment districts of larger cities. Outcomes were the estimated percentage of patrons showing any signs of alcohol intoxication and the overall level of intoxication ('high' versus 'none to medium'). Seven predictors of patron intoxication were examined: hour of observation; estimated percentage of male patrons; estimated percentage of patrons <25 years old; venue crowding; presence of observable alcohol promotions; type of alcoholic beverage consumed by the majority of patrons; and, venue type. Time of night (coefficient=11.71, p<.001; OR=9.61, p<.001), percentage of patrons aged <25 (coefficient=0.14, p<.001; OR=1.01, p=.031), and venue crowding (coefficient=4.40, p<.001; OR=1.39, p=.009) had significant positive associations with both signs of intoxication and high levels of intoxication. Nightclubs had a lower percentage of signs of intoxication compared to pubs (coefficient=-10.73, p=.021). Increased percentage of male patrons was associated with increased odds of high-level intoxication (OR=1.05, p=.020). Time of night and proportion of younger patrons had a strong association with patron intoxication adding further support for the strong body of evidence that ceasing service of alcohol earlier in the evening will reduce intoxication levels. Copyright © 2016 Elsevier B.V. All rights reserved.

Adult bacterial meningitis-a quality registry study: earlier treatment and favourable outcome if initial management by infectious diseases physicians.

PubMed

Grindborg, Ö; Naucler, P; Sjölin, J; Glimåker, M

2015-06-01

Acute bacterial meningitis (ABM) is challenging for the admitting physician because it is a rare but fulminant disease, usually presenting without typical symptoms, and rapid treatment is pivotal. The purpose of this study was to evaluate the effect of initial management by infectious diseases (ID) physicians vs. non-ID physicians. A total of 520 consecutive adults (>17 years old), 110 with initial ID management and 410 with non-ID management, registered in the Swedish quality registry for community-acquired ABM January 2008 to December 2013, were analysed retrospectively. Primary outcome was appropriate treatment with antibiotics and corticosteroids <1 hour from admission. Secondary analyses were mortality during hospital stay and persisting neurological and hearing deficits at follow-up after 2 to 6 months. Differences in diagnostic treatment sequences also were analysed. Appropriate treatment <1 hour from admission was achieved significantly more often (41%) by ID physicians vs. non-ID physicians (24%) with an odds ratio (OR) of 2.4 (95% confidence interval [CI]: 1.40 to 4.14; p < 0.01) adjusted for confounders. The door-to-antibiotic time was significantly shorter, and significantly more patients were administered corticosteroids together with the first doses of antibiotics in the ID group. A trend of decreased mortality (4.5% vs. 8.0%) and sequelae at follow-up (24% vs. 44%; adjusted OR 0.55: 95% CI 0.31 to 1.00; p 0.05) were observed in the ID group vs. the non-ID group. Antibiotics were started without prior neuroimaging more often in the ID group (86% vs. 57%; p < 0.001). Initial management at the emergency department by ID physicians is associated with earlier appropriate treatment, more appropriate diagnostic treatment sequences and favourable outcome. Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Adiposity, Dysmetabolic Traits, and Earlier Onset of Female Puberty in Adolescent Offspring of Women With Gestational Diabetes Mellitus: A Clinical Study Within the Danish National Birth Cohort.

PubMed

Grunnet, Louise G; Hansen, Susanne; Hjort, Line; Madsen, Camilla M; Kampmann, Freja B; Thuesen, Anne Cathrine B; Granstrømi, Charlotta; Strøm, Marin; Maslova, Ekaterina; Frikke-Schmidt, Ruth; Damm, Peter; Chavarro, Jorge E; Hu, Frank B; Olsen, Sjurdur F; Vaag, Allan

2017-12-01

Offspring of pregnancies affected by gestational diabetes mellitus (GDM) are at increased risk of the development of type 2 diabetes. However, the extent to which these dysmetabolic traits may be due to offspring and/or maternal adiposity is unknown. We examined body composition and associated cardiometabolic traits in 561 9- to 16-year-old offspring of mothers with GDM and 597 control offspring. We measured anthropometric characteristics; puberty status; blood pressure; and fasting glucose, insulin, C-peptide, and lipid levels; and conducted a DEXA scan in a subset of the cohort. Differences in the outcomes between offspring of mothers with GDM and control subjects were examined using linear and logistic regression models. After adjustment for age and sex, offspring of mothers with GDM displayed higher weight, BMI, waist-to-hip ratio (WHR), systolic blood pressure, and resting heart rate and lower height. Offspring of mothers with GDM had higher total and abdominal fat percentages and lower muscle mass percentages, but these differences disappeared after correction for offspring BMI. The offspring of mothers with GDM displayed higher fasting plasma glucose, insulin, C-peptide, HOMA-insulin resistance (IR), and plasma triglyceride levels, whereas fasting plasma HDL cholesterol levels were decreased. Female offspring of mothers with GDM had an earlier onset of puberty than control offspring. Offspring of mothers with GDM had significantly higher BMI, WHR, fasting glucose, and HOMA-IR levels after adjustment for maternal prepregnancy BMI, and glucose and HOMA-IR remained elevated in the offspring of mothers with GDM after correction for both maternal and offspring BMIs. In summary, adolescent offspring of women with GDM show increased adiposity, an adverse cardiometabolic profile, and earlier onset of puberty among girls. Increased fasting glucose and HOMA-IR levels among the offspring of mothers with GDM may be explained by the programming effects of hyperglycemia

Recent slowing of Atlantic overturning circulation as a recovery from earlier strengthening

NASA Astrophysics Data System (ADS)

Jackson, Laura C.; Peterson, K. Andrew; Roberts, Chris D.; Wood, Richard A.

2016-07-01

The Atlantic meridional overturning circulation (AMOC) has weakened substantially over the past decade. Some weakening may already have occurred over the past century, and global climate models project further weakening in response to anthropogenic climate change. Such a weakening could have significant impacts on the surface climate. However, ocean model simulations based on historical conditions have often found an increase in overturning up to the mid-1990s, followed by a decrease. It is therefore not clear whether the observed weakening over the past decade is part of decadal variability or a persistent weakening. Here we examine a state-of-the-art global-ocean reanalysis product, GloSea5, which covers the years 1989 to 2015 and closely matches observations of the AMOC at 26.5° N, capturing the interannual variability and decadal trend with unprecedented accuracy. The reanalysis data place the ten years of observations--April 2004 to February 2014--into a longer-term context and suggest that the observed decrease in the overturning circulation is consistent with a recovery following a previous increase. We find that density anomalies that propagate southwards from the Labrador Sea are the most likely cause of these variations. We conclude that decadal variability probably played a key role in the decline of the AMOC observed over the past decade.

Return to work in people with acquired brain injury: association with observed ability to use everyday technology.

PubMed

Larsson-Lund, Maria; Kottorp, Anders; Malinowsky, Camilla

2017-07-01

The aim of this study was to explore how the observed ability to use everyday technology (ET), intrapersonal capacities and environmental characteristics related to ET use contributes to the likelihood of return to work in people with ABI. The aim was also to explore whether these variables added to the likelihood of return to work to earlier defined significant variables in the group: age, perceived ADL ability and perceived ability in ET use. A cross-sectional study. The Management of Everyday Technology Assessment (META), the short version of the Everyday Technology Use Questionnaire (S-ETUQ) and a revised version of the ADL taxonomy were used to evaluate 74 people with ABI. Individual ability measures from all assessments were generated by Rasch analyses and used for additional statistical analysis. The univariate analyses showed that the observed ability to use ET, as well as intrapersonal capacities and environmental characteristics related to ET use were all significantly associated with returning to work. In the multivariate analyses, none of these associations remained. The explanatory precision of return to work in people with ABI increased minimally by adding the observed ability to use ET and the variables related to ET use when age, perceived ability in ET use and ADL had been taken in account.

What do the data show? Fostering physical intuition with ClimateBits and NASA Earth Observations

NASA Astrophysics Data System (ADS)

Schollaert Uz, S.; Ward, K.

2017-12-01

Through data visualizations using global satellite imagery available in NASA Earth Observations (NEO), we explain Earth science concepts (e.g. albedo, urban heat island effect, phytoplankton). We also provide examples of ways to explore the satellite data in NEO within a new blog series. This is an ideal tool for scientists and non-scientists alike who want to quickly check satellite imagery for large scale features or patterns. NEO analysis requires no software or plug-ins; only a browser and an internet connection. You can even check imagery and perform simple analyses from your smart phone. NEO can be used to create graphics for presentations and papers or as a first step before acquiring data for more rigorous analysis. NEO has potential application to easily explore large scale environmental and climate patterns that impact operations and infrastructure. This is something we are currently exploring with end user groups.

Children with autism show specific handwriting impairments

PubMed Central

Fuentes, Christina T.; Mostofsky, Stewart H.; Bastian, Amy J.

2009-01-01

Background: Handwriting skills, which are crucial for success in school, communication, and building children’s self-esteem, have been observed to be poor in individuals with autism. Little information exists on the handwriting of children with autism, without delineation of specific features that can contribute to impairments. As a result, the specific aspects of handwriting in which individuals with autism demonstrate difficulty remain unknown. Methods: A case-control study of handwriting samples from children with and without autism spectrum disorders (ASD) was performed using the Minnesota Handwriting Assessment. Samples were scored on an individual letter basis in 5 categories: legibility, form, alignment, size, and spacing. Subjects were also tested on the Wechsler Intelligence Scale for Children–IV and the Physical and Neurological Examination for Subtle (Motor) Signs. Results: We found that children with ASD do indeed show overall worse performance on a handwriting task than do age- and intelligence-matched controls. More specifically, children with ASD show worse quality of forming letters but do not show differences in their ability to correctly size, align, and space their letters. Within the ASD group, motor skills were significantly predictive of handwriting performance, whereas age, gender, IQ, and visuospatial abilities were not. Conclusions: We addressed how different elements of handwriting contribute to impairments observed in children with autism. Our results suggest that training targeting letter formation, in combination with general training of fine motor control, may be the best direction for improving handwriting performance in children with autism. GLOSSARY ADI-R = Autism Diagnostic Interview–Revised; ADOS-G = Autism Diagnostic Observation Schedule–Generic; ASD = autism spectrum disorders; DICA-IV = Diagnostic Interview for Children and Adolescents, 4th edition; DSM-IV = Diagnostic and Statistical Manual of Mental Disorders, 4th

Characterizing Giant Exoplanets through Multiwavelength Transit Observations: HAT-P-5 b

NASA Astrophysics Data System (ADS)

PeQueen, David Jeffrey; Cole, Jackson Lane; Gardner, Cristilyn N.; Garver, Bethany Ray; Jarka, Kyla L.; Kar, Aman; McGough, Aylin M.; Rivera, Daniel Ivan; Kasper, David; Jang-Condell, Hannah; Kobulnicky, Henry; Dale, Daniel

2018-01-01

During the summer of 2017, we observed hot Jupiter-type exoplanet transit events using the Wyoming Infrared Observatory’s 2.3 meter telescope. We observed 14 unique exoplanets during transit events; one such target was HAT-P-5 b. In total, we collected 53 usable science images in the Sloan filter set, particularly with the g’, r’, z’, and i’ band wavelength filters. This exoplanet transited approximately 40 minutes earlier than the currently published literature suggests. After reducing the data and running a Markov chain Monte Carlo analysis, we present results describing the planetary radius, semi-major axis, orbital period, and inclination of HAT-P-5 b. Characteristics of Rayleigh scattering are present in the atmosphere of this exoplanet. This work is supported by the National Science Foundation under REU grant AST 1560461.

11. Historic view of Building 100 control room, showing personnel ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Historic view of Building 100 control room, showing personnel operating rocket engine test controls and observer watching activity from observation room. May 27, 1957. On file at NASA Plumbrook Research Center, Sandusky, Ohio. NASA photo number C-45020. - Rocket Engine Testing Facility, GRC Building No. 100, NASA Glenn Research Center, Cleveland, Cuyahoga County, OH

Arctic and Antarctic Sea Ice, 1978-1987: Satellite Passive-Microwave Observations and Analysis

NASA Technical Reports Server (NTRS)

Gloersen, Per; Campbell, William J.; Cavalieri, Donald J.; Comiso, Josefino C.; Parkinson, Claire L.; Zwally, H. Jay

1992-01-01

This book contains a description and analysis of the spatial and temporal variations in the Arctic and Antarctic sea ice covers from October 26, 1978 through August 20, 1987. It is based on data collected by the Scanning Multichannel Microwave Radiometer (SMMR) onboard the NASA Nimbus 7 satellite. The 8.8-year period, together with the 4 years of the Nimbus 5 Electrically Scanning Microwave Radiometer (ESMR) observations presented in two earlier volumes, comprises a sea ice record spanning almost 15 years.

Coronal magnetic structures observing campaign. I - Simultaneous microwave and soft X-ray observations of active regions at the solar limb

NASA Astrophysics Data System (ADS)

Nitta, N.; White, S. M.; Kundu, M. R.; Gopalswamy, N.; Holman, G. D.; Brosius, J. W.; Schmelz, J. T.; Saba, J. L. R.; Strong, K. T.

1991-06-01

Using simultaneous microwave and soft X-ray measurements made with the Very Large Array (VLA) at 6 and 20 cm and the X-ray Polychromator (XRP) aboard the Solar Maximum Mission (SMM), we have studied two active regions near the solar limb. These observations were taken as part of the Coronal Magnetic Structures Observing Campaign (CoMStOC), a collaboration designed to study the magnetic field in the solar corona. The images in soft X-rays and at 20 cm wavelength are similar: both show peaks above the active regions and extended bridge of emission 200,000 km long connecting the two regions. The brightness temperature of the 20 cm emission is lower than that predicted from the X-ray emitting material, however; it can be attributed to free-free emission in cooler (<106 K) plasma not visible to XRP, with an optical depth ˜1. The 6 cm emission is concentrated at lower altitudes and in a ˜160,000 km long bundle of loops in the northern active region. Comparison of the 6 cm map with the potential magnetic field lines computed from photospheric magnetic fields (measured 2 days earlier) indicates that the 6 cm emission is associated with fields of less than ˜200 G. Such fields would be too weak to attribute the observed 6 cm emission to gyroresonance radiation. Analysis of the 6 cm loop bundle indicates that it is strongly asymmetric, with the magnetic field in the northern leg ˜2 times stronger than in the southern leg; the 6 cm emission most likely arises from a combination of hot ( ≥ 2 × 106 K) and cool plasmas, while the 20 cm emission becomes optically thick in the cooler (˜9 × 103 K) plasma. We estimate an Alfvén speed ˜7000 km s-1 and ratio of electron gyrofrequency to plasma frequency ˜1.0 in the northern leg of the 6 cm loop.

New Inspiring Planetarium Show Introduces ALMA to the Public

NASA Astrophysics Data System (ADS)

2009-03-01

As part of a wide range of education and public outreach activities for the International Year of Astronomy 2009 (IYA2009), ESO, together with the Association of French Language Planetariums (APLF), has produced a 30-minute planetarium show, In Search of our Cosmic Origins. It is centred on the global ground-based astronomical Atacama Large Millimeter/submillimeter Array (ALMA) project and represents a unique chance for planetariums to be associated with the IYA2009. ESO PR Photo 09a/09 Logo of the ALMA Planetarium Show ESO PR Photo 09b/09 Galileo's first observations with a telescope ESO PR Photo 09c/09 The ALMA Observatory ESO PR Photo 09d/09 The Milky Way band ESO PR Video 09a/09 Trailer in English ALMA is the leading telescope for observing the cool Universe -- the relic radiation of the Big Bang, and the molecular gas and dust that constitute the building blocks of stars, planetary systems, galaxies and life itself. It is currently being built in the extremely arid environment of the Chajnantor plateau, at 5000 metres altitude in the Chilean Andes, and will start scientific observations around 2011. ALMA, the largest current astronomical project, is a revolutionary telescope, comprising a state-of-the-art array of 66 giant 12-metre and 7-metre diameter antennas observing at millimetre and submillimetre wavelengths. In Search of our Cosmic Origins highlights the unprecedented window on the Universe that this facility will open for astronomers. "The show gives viewers a fascinating tour of the highest observatory on Earth, and takes them from there out into our Milky Way, and beyond," says Douglas Pierce-Price, the ALMA Public Information Officer at ESO. Edited by world fulldome experts Mirage3D, the emphasis of the new planetarium show is on the incomparable scientific adventure of the ALMA project. A young female astronomer guides the audience through a story that includes unique animations and footage, leading the viewer from the first observations by Galileo

On the observations of unique low latitude whistler-triggered VLF/ELF emissions

NASA Astrophysics Data System (ADS)

Altaf, M.; Singh, K. K.; Singh, A. K.; Lalmani

A detailed analysis of the VLF/ELF wave data obtained during a whistler campaign under All India Coordinated Program of Ionosphere Thermosphere Studies (AICPITS) at our low latitude Indian ground station Jammu (geomag. lat. = 22° 26‧ N, L = 1.17) has yielded two types of unusual and unique whistler-triggered VLF/ELF emissions. These include (1) whistler-triggered hook emissions and (2) whistler-triggered long enduring discrete chorus riser emissions in VLF/ELF frequency range during night time. Such types of whistler-triggered emissions have not been reported earlier from any of the ground observations at low latitudes. In the present study, the observed characteristics of these emissions are described and interpreted. Dispersion analysis of these emissions show that the whistlers as well as emissions have propagated along a higher geomagnetic field line path with L-values lying ∼L = 4, suggesting that these triggered emissions are to be regarded as mid-latitude emissions. These waves could have propagated along the geomagnetic field lines either in a ducted mode or in a pro-longitudinal (PL) mode. The measured intensity of the triggered emissions is almost equal to that of the source waves and does not vary throughout the period of observation on that day. It is speculated that these emissions may have been generated through a process of resonant interaction of the whistler waves with energetic electrons. Parameters related to this interaction are computed for different values of L and wave amplitude. The proposed mechanism explains some aspects of the dynamic spectra.

Interannual Rainfall Variability in North-East Brazil: Observation and Model Simulation

NASA Astrophysics Data System (ADS)

Harzallah, A.; Rocha de Aragão, J. O.; Sadourny, R.

1996-08-01

The relationship between interannual variability of rainfall in north-east Brazil and tropical sea-surface temperature is studied using observations and model simulations. The simulated precipitation is the average of seven independent realizations performed using the Laboratoire de Météorologie Dynamique atmospheric general model forced by the 1970-1988 observed sea-surface temperature. The model reproduces very well the rainfall anomalies (correlation of 091 between observed and modelled anomalies). The study confirms that precipitation in north-east Brazil is highly correlated to the sea-surface temperature in the tropical Atlantic and Pacific oceans. Using the singular value decomposition method, we find that Nordeste rainfall is modulated by two independent oscillations, both governed by the Atlantic dipole, but one involving only the Pacific, the other one having a period of about 10 years. Correlations between precipitation in north-east Brazil during February-May and the sea-surface temperature 6 months earlier indicate that both modes are essential to estimate the quality of the rainy season.

Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules

NASA Astrophysics Data System (ADS)

Imai, Hiroshi; Shima, Tomohiro; Sutoh, Kazuo; Walker, Matthew L.; Knight, Peter J.; Kon, Takahide; Burgess, Stan A.

2015-09-01

Cytoplasmic dynein is a dimeric AAA+ motor protein that performs critical roles in eukaryotic cells by moving along microtubules using ATP. Here using cryo-electron microscopy we directly observe the structure of Dictyostelium discoideum dynein dimers on microtubules at near-physiological ATP concentrations. They display remarkable flexibility at a hinge close to the microtubule binding domain (the stalkhead) producing a wide range of head positions. About half the molecules have the two heads separated from one another, with both leading and trailing motors attached to the microtubule. The other half have the two heads and stalks closely superposed in a front-to-back arrangement of the AAA+ rings, suggesting specific contact between the heads. All stalks point towards the microtubule minus end. Mean stalk angles depend on the separation between their stalkheads, which allows estimation of inter-head tension. These findings provide a structural framework for understanding dynein's directionality and unusual stepping behaviour.

VLA's Sharpened Vision Shows Details of Still-Forming Star

NASA Astrophysics Data System (ADS)

2001-01-01

available for routine astronomical observations last autumn. In late November, the scientists pointed the sharpened vision of the combined telescopes at an object called G192.16-3.82, more than 6,000 light-years distant in the constellation Orion. First observed in 1990, G192.16-3.82 was found to be a massive young star powering one of the largest stellar outflows -- extending more than 30 light years from end to end -- in the entire Milky Way Galaxy. Earlier observations showed the young star is surrounded by a large, rotating disk with a diameter greater than 1,000 times the Sun-Earth distance. Astronomers, however, believed that the outflow had to originate from a structure much smaller than this disk. The VLA-Pie Town system gave them their first glimpse of the suspected smaller structure, another disk slightly larger than our own Solar System containing enough gas and dust to make 20 Suns. In addition, they saw the inner portion of the outflow of material powered by that disk. The new observations also showed that the smaller disk probably is truncated by the gravitational pull of another, previously-unseen young star less massive than the first. Close to the larger protostar, the outflow is wide, covering an angle of about 40 degrees. "With smaller protostars, the outflow begins wide but then is narrowed down to a thin jet relatively close to its origin. However, when the protostar is more massive, the outflow tends to remain wide," Shepherd said. "We think that magnetic fields narrow down the flow from the smaller protostars. It's possible that when the flow contains much more mass, such as in this system, the magnetic fields may be just too weak in most cases to get this done," she said. "Our new observations now make it possible to test this idea by comparing computer simulations to what we see in the real universe," Shepherd said. The VLA is a system of 27 radio-telescope antennas distributed over the high desert west of Socorro, NM, in the shape of a giant "Y

Monitoring recovery from rocuronium-induced neuromuscular block using acceleromyography at the trapezius versus the adductor pollicis muscle: an observational trial.

PubMed

Soltesz, Stefan; Stark, Christian; Noé, Karl G; Anapolski, Michael; Mencke, Thomas

2016-06-01

Positioning for surgery can restrict access to the patient's hand, thereby limiting assessment of the response at the adductor pollicis muscle to ulnar nerve stimulation. We evaluated a novel site to assess neuromuscular block by stimulating the accessory nerve and measuring the acceleromyographic response at the trapezius muscle. In this prospective non-blinded observational study, we assessed neuromuscular transmission in anesthetized adult female patients undergoing elective laparoscopic gynecological surgery. We performed the assessment by simultaneous recording acceleromyographic responses with the TOF-Watch(®) SX monitor at both the right adductor pollicis and left trapezius muscles. The neuromuscular block was achieved using rocuronium 0.3 mg·kg(-1), and the repeatability, time course, and limits of agreement (Bland-Altman) of responses were compared at the two recording sites. The primary endpoint was the 90% train-of-four (TOF) recovery time with other endpoints included the onset time of the block, maximum T1 depression, time to 25% T1 recovery, and recovery time course of the T1 response and TOF ratio. Thirty-six patients were enrolled with responses obtained from 27 subjects. The variability of baseline responses recorded at the trapezius muscle was larger than that recorded at the adductor pollicis muscle, as determined by their mean (SD) repeatability coefficients [twitch height T1, 6.1 (1.9)% and 4.2 (1.6)%, respectively; P = 0.001; TOF ratio, 6.2 (2.1)% and 4.3 (1.7)%, respectively; P = 0.001]. The recorded responses showed relatively narrow limits of agreement. The onset time of the block was 0.3 min earlier at the trapezius muscle than at the adductor pollicis muscle [2.3 (0.8) min and 2.6 (0.7) min, respectively; P = 0.007], with limits of agreement ranging from 1.6 min earlier to 1.0 min later. The time to 25% T1 recovery was 1.8 min earlier at the trapezius muscle than at the adductor pollicis muscle [18.2 (5.7) min and 20.0 (5.2) min

Ensemble-sensitivity Analysis Based Observation Targeting for Mesoscale Convection Forecasts and Factors Influencing Observation-Impact Prediction

NASA Astrophysics Data System (ADS)

Hill, A.; Weiss, C.; Ancell, B. C.

2017-12-01

The basic premise of observation targeting is that additional observations, when gathered and assimilated with a numerical weather prediction (NWP) model, will produce a more accurate forecast related to a specific phenomenon. Ensemble-sensitivity analysis (ESA; Ancell and Hakim 2007; Torn and Hakim 2008) is a tool capable of accurately estimating the proper location of targeted observations in areas that have initial model uncertainty and large error growth, as well as predicting the reduction of forecast variance due to the assimilated observation. ESA relates an ensemble of NWP model forecasts, specifically an ensemble of scalar forecast metrics, linearly to earlier model states. A thorough investigation is presented to determine how different factors of the forecast process are impacting our ability to successfully target new observations for mesoscale convection forecasts. Our primary goals for this work are to determine: (1) If targeted observations hold more positive impact over non-targeted (i.e. randomly chosen) observations; (2) If there are lead-time constraints to targeting for convection; (3) How inflation, localization, and the assimilation filter influence impact prediction and realized results; (4) If there exist differences between targeted observations at the surface versus aloft; and (5) how physics errors and nonlinearity may augment observation impacts.Ten cases of dryline-initiated convection between 2011 to 2013 are simulated within a simplified OSSE framework and presented here. Ensemble simulations are produced from a cycling system that utilizes the Weather Research and Forecasting (WRF) model v3.8.1 within the Data Assimilation Research Testbed (DART). A "truth" (nature) simulation is produced by supplying a 3-km WRF run with GFS analyses and integrating the model forward 90 hours, from the beginning of ensemble initialization through the end of the forecast. Target locations for surface and radiosonde observations are computed 6, 12, and

EUropean prospective cohort study on Enterobacteriaceae showing REsistance to CArbapenems (EURECA): a protocol of a European multicentre observational study.

PubMed

Gutiérrez-Gutiérrez, Belén; Sojo-Dorado, Jesús; Bravo-Ferrer, José; Cuperus, Nienke; de Kraker, Marlieke; Kostyanev, Tomislav; Raka, Lul; Daikos, George; Feifel, Jan; Folgori, Laura; Pascual, Alvaro; Goossens, Herman; O'Brien, Seamus; Bonten, Marc J M; Rodríguez-Baño, Jesús

2017-04-03

The rapid worldwide spread of carbapenem-resistant Enterobacteriaceae (CRE) constitutes a major challenge. The aim of the EUropean prospective cohort study on Enterobacteriaceae showing REsistance to CArbapenems (EURECA), which is part of the Innovative Medicines Initiative Joint Undertaking (IMI JU) funded COMBACTE-CARE project, is to investigate risk factors for and outcome determinants of CRE infections to inform randomised clinical trial designs and to provide a historical cohort that could eventually be used for future comparisons with new drugs targeting CRE. A multicentre (50 sites), multinational (11 European countries), analytical observational project was designed, comprising 3 studies. The aims of study 1 (a prospective cohort study) include characterising the features, clinical management and outcomes of hospitalised patients with intra-abdominal infection, pneumonia, complicated urinary tract infections and bloodstream infections caused by CRE (202 patients in each group). The main outcomes will be 30-day all-cause mortality and clinical response. Study 2 (a nested case-control study) will identify the risk factors for target infections caused by CRE; 248 selected patients from study 1 will be matched with patients with carbapenem-susceptible Enterobacteriaceae (1:1) and with hospitalised patients (1:3) and will provide a historical cohort of patients with CRE infections. Study 3 (a matched cohort study) will follow patients in study 2 in order to assess mortality, length of stay and hospital costs associated with CRE. All patients will be followed for 30 days. Different, up-to-date statistical methods will be applied to come to unbiased estimates for all 3 studies. Before-study sites will be initiated, approval will be sought from appropriate regulatory agencies and local Ethics Committees of Research or Institutional Review Boards (IRBs) to conduct the study in accordance with regulatory requirements. This is an observational study and therefore no

Diurnal, monthly and seasonal variation of mean winds in the MLT region observed over Kolhapur using MF radar

NASA Astrophysics Data System (ADS)

Sharma, A. K.; Gaikwad, H. P.; Ratnam, M. Venkat; Gurav, O. B.; Ramanjaneyulu, L.; Chavan, G. A.; Sathishkumar, S.

2018-04-01

Medium Frequency (MF) radar located at Kolhapur (16.8°N, 74.2°E) has been upgraded in August 2013. Since then continuous measurements of zonal and meridional winds are obtained covering larger altitudes from the Mesosphere and Lower Thermosphere (MLT) region. Diurnal, monthly and seasonal variation of these mean winds is presented in this study using four years (2013-2017) of observations. The percentage occurrence of radar echoes show maximum between 80 and 105 km. The mean meridional wind shows Annual Oscillation (AO) between 80 and 90 km altitudes with pole-ward motion during December solstice and equatorial motion during June solstice. Quasi-biennial oscillation (QBO) with weaker amplitudes are also observed between 90 and 104 km. Zonal winds show semi-annual oscillation (SAO) with westward winds during equinoxes and eastward winds during solstices between 80 and 90 km. AO with eastward winds during December solstice and westward wind in the June solstice is also observed in the mean zonal wind between 100 and 110 km. These results match well with that reported from other latitudes within Indian region between 80 and 90 km. However, above 90 km the results presented here provide true mean background winds for the first time over Indian low latitude region as the present station is away from equatorial electro-jet and are not contaminated by ionospheric processes. Further, the results presented earlier with an old version of this radar are found contaminated due to unknown reasons and are corrected in the present work. This upgraded MF radar together with other MLT radars in the Indian region forms unique network to investigate the vertical and lateral coupling.

A photometric study of the Orion OB 1 association. 1: Observational data

NASA Technical Reports Server (NTRS)

Warren, W. H., Jr.; Hesser, J. E.

1976-01-01

An extensive catalog of observational data is presented for stars in the region of the young stellar association Orion OB 1. In addition to new photoelectric observations obtained on the uvbyB and UBV systems, photoelectric and spectroscopic data were compiled for the stars observed and for several bright members of the association having available photometric indices. Mean weighted values were computed for the uvbyB and UBV data and are tabulated in summary tables which include all references for individual values. These tables are expected to be reasonably complete for association members earlier than spectral type A0. From an analysis of currently available proper motion, radial velocity, and photometric data, membership criteria were derived and qualitative membership probabilities for 526 stars were summarized. A set of charts is included for assistance in identification of the program stars in all regions of the association.

Metamorphosis Is Ancestral for Crown Euarthropods, and Evolved in the Cambrian or Earlier.

PubMed

Wolfe, Joanna M

2017-09-01

Macroevolutionary developmental biology employs fossilized ontogenetic data and phylogenetic comparative methods to probe the evolution of development at ancient nodes. Despite the prevalence of ecologically differentiated larval forms in marine invertebrates, it has been frequently presumed that the ancestors of arthropods were direct developers, and that metamorphosis may not have evolved until the Ordovician or later. Using fossils and new dated phylogenies, I infer that metamorphosis was likely ancestral for crown arthropods, contradicting this assumption. Based on a published morphological dataset encompassing 217 exceptionally preserved fossil and 96 extant taxa, fossils were directly incorporated into both the topology and age estimates, as in "tip dating" analyses. Using data from post-embryonic fossils representing 25 species throughout stem and crown arthropod lineages (as well as most of the 96 extant taxa), characters for metamorphosis were assigned based on inferred ecological changes in development (e.g., changes in habitat and adaptive landscape). Under all phylogenetic hypotheses, metamorphosis was supported as most likely ancestral to both ecdysozoans and euarthropods. Care must be taken to account for potential drastic post-embryonic morphological changes in evolutionary analyses. Many stem group euarthrpods may have had ecologically differentiated larval stages that did not preserve in the fossil record. Moreover, a complex life cycle and planktonic ecology may have evolved in the Ediacaran or earlier, and may have typified the pre-Cambrian explosion "wormworld" prior to the origin of crown group euarthropods. © The Author 2017. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

The evaluation of clinical and cost outcomes associated with earlier initiation of insulin in patients with type 2 diabetes mellitus.

PubMed

Smolen, Harry J; Murphy, Daniel R; Gahn, James C; Yu, Xueting; Curtis, Bradley H

2014-09-01

The treatment for patients with type 2 diabetes mellitus (T2DM) follows a stepwise progression. As a treatment loses its effectiveness, it is typically replaced with a more complex and frequently more costly treatment. Eventually this progression leads to the use of basal insulin typically with concomitant treatments (e.g., metformin, a GLP-1 RA [glucagon-like peptide-1 receptor agonist], a TZD [thiazolidinedione] or a DPP-4i [dipeptidyl peptidase 4 inhibitor]) and, ultimately, to basal-bolus insulin in some forms. As the cost of oral antidiabetics (OADs) and noninsulin injectables have approached, and in some cases exceeded, the cost of insulin, we reexamined the placement of insulin in T2DM treatment progression. Our hypothesis was that earlier use of insulin produces clinical and cost benefits due to its superior efficacy and treatment scalability at an acceptable cost when considered over a 5-year period. To (a) estimate clinical and payer cost outcomes of initiating insulin treatment for patients with T2DM earlier in their treatment progression and (b) estimate clinical and payer cost outcomes resulting from delays in escalating treatment for T2DM when indicated by patient hemoglobin A1c levels. We developed a Monte Carlo microsimulation model to estimate patients reaching target A1c, diabetes-related complications, mortality, and associated costs under various treatment strategies for newly diagnosed patients with T2DM. Treatment efficacies were modeled from results of randomized clinical trials, including the time and rate of A1c drift. A typical treatment progression was selected based on the American Diabetes Association and the European Association for the Study of Diabetes guidelines as the standard of care (SOC). Two treatment approaches were evaluated: two-stage insulin (basal plus antidiabetics followed by biphasic plus metformin) and single-stage insulin (biphasic plus metformin). For each approach, we analyzed multiple strategies. For each analysis

Like cognitive function, decision making across the life span shows profound age-related changes.

PubMed

Tymula, Agnieszka; Rosenberg Belmaker, Lior A; Ruderman, Lital; Glimcher, Paul W; Levy, Ifat

2013-10-15

It has long been known that human cognitive function improves through young adulthood and then declines across the later life span. Here we examined how decision-making function changes across the life span by measuring risk and ambiguity attitudes in the gain and loss domains, as well as choice consistency, in an urban cohort ranging in age from 12 to 90 y. We identified several important age-related patterns in decision making under uncertainty: First, we found that healthy elders between the ages of 65 and 90 were strikingly inconsistent in their choices compared with younger subjects. Just as elders show profound declines in cognitive function, they also show profound declines in choice rationality compared with their younger peers. Second, we found that the widely documented phenomenon of ambiguity aversion is specific to the gain domain and does not occur in the loss domain, except for a slight effect in older adults. Finally, extending an earlier report by our group, we found that risk attitudes across the life span show an inverted U-shaped function; both elders and adolescents are more risk-averse than their midlife counterparts. Taken together, these characterizations of decision-making function across the life span in this urban cohort strengthen the conclusions of previous reports suggesting a profound impact of aging on cognitive function in this domain.

Earlier Detection of Tumor Treatment Response Using Magnetic Resonance Diffusion Imaging with Oscillating Gradients

PubMed Central

Colvin, Daniel C.; Loveless, Mary E.; Does, Mark D.; Yue, Zou; Yankeelov, Thomas E.; Gore, John C.

2011-01-01

An improved method for detecting early changes in tumors in response to treatment, based on a modification of diffusion-weighted magnetic resonance imaging, has been demonstrated in an animal model. Early detection of therapeutic response in tumors is important both clinically and in pre-clinical assessments of novel treatments. Non-invasive imaging methods that can detect and assess tumor response early in the course of treatment, and before frank changes in tumor morphology are evident, are of considerable interest as potential biomarkers of treatment efficacy. Diffusion-weighted magnetic resonance imaging is sensitive to changes in water diffusion rates in tissues that result from structural variations in the local cellular environment, but conventional methods mainly reflect changes in tissue cellularity and do not convey information specific to micro-structural variations at sub-cellular scales. We implemented a modified imaging technique using oscillating gradients of the magnetic field for evaluating water diffusion rates over very short spatial scales that are more specific for detecting changes in intracellular structure that may precede changes in cellularity. Results from a study of orthotopic 9L gliomas in rat brains indicate that this method can detect changes as early as 24 hours following treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), when conventional approaches do not find significant effects. These studies suggest that diffusion imaging using oscillating gradients may be used to obtain an earlier indication of treatment efficacy than previous magnetic resonance imaging methods. PMID:21190804

Plasmaspheric Plumes Observed by the CLUSTER and IMAGE Spacecraft

NASA Technical Reports Server (NTRS)

Fung, S. F.; Benson, R. F.; Garcia, L. N.; Adrian, M. L.; Sandel, B.; Goldstein, M. L.

2008-01-01

Global IMAGE/EUV observations have revealed complex changes in plasmaspheric structures as the plasmasphere responds to geomagnetic activity while remaining under varying degrees of influence by co-rotation, depending on the radial distance. The complex plasmaspheric dynamics, with different scales of variability, is clearly far from being well understood. There is now renewed interest in the plasmasphere due to its apparent connections with the development of the ring current and radiation belt, and loss of ionospheric plasmas. Early in the mission, the Cluster spacecraft only crossed the plasmapause (L - 4) occasionally and made measurements of the outer plasmasphere and plasmaspheric drainage plumes. The study by Darrouzet et al. [2006] provided detailed analyses of in situ Cluster observations and IMAGE EUV observations of three plasmaspheric plumes detected in April-June, 2002. Within the next couple of years, Cluster orbit will change, causing perigee to migrate to lower altitudes, and thus providing excellent opportunities to obtain more detailed measurements of the plasmasphere. In this paper, we report our analyses of the earlier Cluster-IMAGE events by incorporating the different perspectives provided by the IMAGE Radio Plasma Imager (RPI) observations. We will discuss our new understanding of the structure and dynamics of the Cluster-IMAGE events.

Lyman-alpha observations of Comet Kohoutek 1973 XII with Copernicus

NASA Technical Reports Server (NTRS)

Drake, J. F.; Jenkins, E. B.; Bertaux, J. L.; Festou, M.; Keller, H. U.

1976-01-01

Comet Kohoutek 1973 XII was observed with a telescope-spectrometer on the Copernicus satellite on six occasions over a 1-month period starting on January 29, 1974. Positive detection of the cometary Ly-alpha emission profile was obtained on January 29 and February 2. Earlier observations of the geocoronal Ly-alpha emission profile allowed an instrumental intensity calibration and confirmation of the computed instrumental profile for an extended source at the Ly-alpha wavelength. After allowing for broadening by the instrument, a hydrogen-outflow velocity of about 10.6 km/s is derived from the width of the Ly-alpha emission on January 29. The intensity calibration combined with an appropriate cometary model led to cometary water-production rates for January 29 and February 2. Only upper limits were obtained for Ly-alpha on and after February 14. Searches for OH and D led to negative results.

UHECR mass composition measurement at Telescope Array via stereoscopic observation

NASA Astrophysics Data System (ADS)

Stroman, Thomas; Telescope Array Collaboration

2015-04-01

The masses of primary ultra-high-energy cosmic-ray (UHECR) nuclei cannot be measured directly on an individual basis, but constraints on the chemical composition can be inferred from the distributions of observable properties. The atmospheric slant depth at which a UHECR-induced extensive air shower reaches its maximum number of particles, Xmax, is particularly sensitive to the mass of the incident nucleus, occurring earlier in the shower's longitudinal development for heavier nuclei at a given energy. The Telescope Array in west-central Utah, the northern hemisphere's largest UHECR detector, is equipped for accurate Xmax and energy measurements via stereoscopic fluorescence observation. Using data from seven years of operation, we will present Xmax distributions at several energies E >10 18 . 2eV , and compare them to distributions predicted by detailed detector simulations under an assortment of assumed UHECR compositions and high-energy hadronic interaction models.

OBSERVATIONS OF THE OPTICAL TRANSIENT IN NGC 300 WITH AKARI/IRC: POSSIBILITIES OF ASYMMETRIC DUST FORMATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ohsawa, R.; Sakon, I.; Onaka, T.

2010-08-01

We present the results of near-infrared (NIR) multi-epoch observations of the optical transient in the nearby galaxy NGC 300 (NGC 300-OT) at 398 and 582 days after the discovery with the Infrared Camera (IRC) on board AKARI. NIR spectra (2-5 {mu}m) of NGC 300-OT were obtained for the first time. They show no prominent emission nor absorption features, but are dominated by continuum thermal emission from the dust around NGC 300-OT. NIR images were taken in the 2.4, 3.2, and 4.1 {mu}m bands. The spectral energy distributions (SEDs) of NGC 300-OT indicate the dust temperature of 810 {+-} 14 Kmore » at 398 days and 670 {+-} 12 K at 582 days. We attribute the observed NIR emission to the thermal emission from dust grains formed in the ejecta of NGC 300-OT. The multi-epoch observations enable us to estimate the dust optical depth as {approx}>12 at 398 days and {approx}>6 at 582 days at 2.4 {mu}m by assuming an isothermal dust cloud. The observed NIR emission must be optically thick, unless the amount of dust grains increases with time. Little extinction at visible wavelengths reported in earlier observations suggests that the dust cloud around NGC 300-OT should be distributed inhomogeneously so as to not screen the radiation from the ejecta gas and the central star. The present results suggest the dust grains are not formed in a spherically symmetric geometry, but rather in a torus, a bipolar outflow, or clumpy cloudlets.« less

Does observability affect prosociality?

PubMed Central

Lawrence, Claire

2018-01-01

The observation of behaviour is a key theoretical parameter underlying a number of models of prosociality. However, the empirical findings showing the effect of observability on prosociality are mixed. In this meta-analysis, we explore the boundary conditions that may account for this variability, by exploring key theoretical and methodological moderators of this link. We identified 117 papers yielding 134 study level effects (total n = 788 164) and found a small but statistically significant, positive association between observability and prosociality (r = 0.141, 95% confidence interval = 0.106, 0.175). Moderator analysis showed that observability produced stronger effects on prosociality: (i) in the presence of passive observers (i.e. people whose role was to only observe participants) versus perceptions of being watched, (ii) when participants’ decisions were consequential (versus non-consequential), (iii) when the studies were performed in the laboratory (as opposed to in the field/online), (iv) when the studies used repeated measures (instead of single games), and (v) when the studies involved social dilemmas (instead of bargaining games). These effects show the conditions under which observability effects on prosociality will be maximally observed. We describe the theoretical and practical significance of these results. PMID:29593114

Does observability affect prosociality?

PubMed

Bradley, Alex; Lawrence, Claire; Ferguson, Eamonn

2018-03-28

The observation of behaviour is a key theoretical parameter underlying a number of models of prosociality. However, the empirical findings showing the effect of observability on prosociality are mixed. In this meta-analysis, we explore the boundary conditions that may account for this variability, by exploring key theoretical and methodological moderators of this link. We identified 117 papers yielding 134 study level effects (total n = 788 164) and found a small but statistically significant, positive association between observability and prosociality ( r = 0.141, 95% confidence interval = 0.106, 0.175). Moderator analysis showed that observability produced stronger effects on prosociality: (i) in the presence of passive observers (i.e. people whose role was to only observe participants) versus perceptions of being watched, (ii) when participants' decisions were consequential (versus non-consequential), (iii) when the studies were performed in the laboratory (as opposed to in the field/online), (iv) when the studies used repeated measures (instead of single games), and (v) when the studies involved social dilemmas (instead of bargaining games). These effects show the conditions under which observability effects on prosociality will be maximally observed. We describe the theoretical and practical significance of these results. © 2018 The Authors.

Well-observed dynamics of flaring and peripheral coronal magnetic loops during an M-class limb flare

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen, Jinhua; Zhou, Tuanhui; Ji, Haisheng

2014-08-20

In this paper, we present a variety of well-observed dynamic behaviors for the flaring and peripheral magnetic loops of the M6.6 class extreme limb flare that occurred on 2011 February 24 (SOL2011-02-24T07:20) from EUV observations by the Atmospheric Imaging Assembly on the Solar Dynamics Observatory and X-ray observations by RHESSI. The flaring loop motion confirms the earlier contraction-expansion picture. We find that the U-shaped trajectory delineated by the X-ray corona source of the flare roughly follows the direction of a filament eruption associated with the flare. Different temperature structures of the coronal source during the contraction and expansion phases stronglymore » suggest different kinds of magnetic reconnection processes. For some peripheral loops, we discover that their dynamics are closely correlated with the filament eruption. During the slow rising to abrupt, fast rising of the filament, overlying peripheral magnetic loops display different responses. Two magnetic loops on the elbow of the active region had a slow descending motion followed by an abrupt successive fast contraction, while magnetic loops on the top of the filament were pushed outward, slowly being inflated for a while and then erupting as a moving front. We show that the filament activation and eruption play a dominant role in determining the dynamics of the overlying peripheral coronal magnetic loops.« less

Observing Recent Changes in the Large-Scale Arctic Energy Budget

NASA Astrophysics Data System (ADS)

Porter, D. F.; Serreze, M.; Cassano, J.

2008-12-01

Changes in the large-scale energy budget of the Arctic are examined using a variety of next-generation reanalysis and observational data. An effort is made to construct a best-guess of the current arctic energy budget using a variety of atmospheric data. For the period of 2000-2005, monthly means from the Clouds and the Earth's Radiant Energy System (CERES) data represents the current most-reliable top of atmosphere radiation budget. The remaining components of the energy budget system in the arctic polar cap (defined as 70 degrees North latitude circle), comprising of the vertically-integrated storage and horizontal transports of energy, and net heat transfers between the atmosphere and the subsurface column, are diagnosed using the Japanese 25-year Reanalysis Project (JRA-25) and the NCEP/NCAR Reanalysis (NRA). The as then record-setting minimum sea-ice extent during the 2005 melt season is used as a marker of recent changes occurring in the arctic climate system. However, changes in each reanalysis differs than the satellite observations. In one example, when compared to the 2000-2005 climatology, CERES shows a shift in the peak TOA radiation from July to June in 2005, a change that is absent in the reanalyses and directly attributable to the early and pronounced albedo reduction. An earlier peak in TOA radiation can strongly modulate the flux energy convergence from lower latitudes through circulation changes. Here, the energy budget framework provides a simplified view of the pathway through which changes of key component parings occur.

Observed Changes at Viking Lander 1

NASA Technical Reports Server (NTRS)

Moore, H. J.

1985-01-01

A local dust storm raged in Chryse Planitia, Mars, in June 1981. The changes wrought in the vicinity of the lander (Mutch Memorial Station) by this storm sometime near Sol 1742 were partly described previously. Here, changes related to the storm are itemized, evidence for wind directions during the peak of the storm are cited, and two observations unrelated to the storm are noted. The observations suggest that the eroding winds of the Sol 1742 storm were more easterly (N. 35 deg to 90 deg E.) than those (N. 5 deg to 11 deg E.) that formed the large wind tails; and fragments in erosional residues are 0.7 cm and larger, but smaller ones may be present. Some fragments 0.4 to 0.5 cm and smaller were somehow removed, at least locally; wind speeds of the 1742 local storm were probably greater than those of a previous local dust storm (25 to 30 m/s) that occurred during the same season on Sol 423 because the earlier storm did not alter the surface; the major, if not entire, amount of erosion by the storm occurred between Sols 1728 and 1757; and erosion chiefly occurred where the surface configuration and material properties were altered by the lander and its sampler.

Listing of 502 Times When the Ulysses Magnetic Fields Instrument Observed Waves Due to Newborn Interstellar Pickup Protons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cannon, Bradford E.; Smith, Charles W.; Isenberg, Philip A.

In two earlier publications we analyzed 502 intervals of magnetic waves excited by newborn interstellar pickup protons that were observed by the Ulysses spacecraft. Due to the considerable effort required in identifying these events, we provide a list of the times for the 502 wave event intervals previously identified. In the process, we provide a brief description of how the waves were found and what their properties are. We also remind the reader of the conditions that permit the waves to reach observable levels and explain why the waves are not seen more often.

Crew Earth Observations (CEO) taken during Expedition Five on the ISS

NASA Image and Video Library

2002-08-23

ISS005-E-10926 (23 August 2002) --- This is the second of two images recently released by the Earth Sciences and Image Analysis Laboratory at Johnson Space Center, showing some of the devastating late summer 2002 European flooding. The images were captured by astronauts using a digital still camera onboard the International Space Station (ISS). The photographs show flooding around the Danube Bend area just north of Budapest near the city of Vác, Hungary. The flood peaked in Budapest four days before this photo was made, on August 19, at about 8.5 meters (28 feet), exceeding the previous 1965 flood record. Water had begun to recede when this image was made. Image no. ISS005-E-10000 shows the area four days earlier.

Adverse childhood experiences predict earlier age of drinking onset: results from a representative US sample of current or former drinkers.

PubMed

Rothman, Emily F; Edwards, Erika M; Heeren, Timothy; Hingson, Ralph W

2008-08-01

Our goal was to determine whether adverse childhood experiences predicted the age at which drinking was initiated and drinking motives in a representative sample of current or former drinkers in the United States. In 2006, a probability sample of 3592 US current or former drinkers aged 18 to 39 were surveyed. Multinomial logistic regression examined whether each of 10 adverse childhood experiences was associated with earlier ages of drinking onset, controlling for demographics, parental alcohol use, parental attitudes toward drinking, and peers' drinking in adolescence. We also examined whether there was a graded relationship between the number of adverse childhood experiences and age of drinking onset and whether adverse childhood experiences were related to self-reported motives for drinking during the first year that respondents drank. Sixty-six percent of respondents reported >or=1 adverse childhood experiences, and 19% reported experiencing >or=4. The most commonly reported adverse childhood experiences were parental separation/divorce (41.3%), living with a household member who was a problem drinker (28.7%), mental illness of a household member (24.8%), and sexual abuse (19.1%). Of the 10 specific adverse childhood experiences assessed, 5 were significantly associated with initiating drinking at or=21 years of age) after adjustment for confounders, including physical abuse, sexual abuse, having a mentally ill household member, substance abuse in the home, and parental discord or divorce. Compared with those without adverse childhood experiences, respondents with adverse childhood experiences were substantially more likely to report that they drank to cope during the first year that they used alcohol. Results suggest that children with particular adverse childhood experiences may initiate drinking earlier than their peers and that they may be more likely to drink to cope with problems (rather than for pleasure or to be

Molecular screening of the ghrelin gene in Italian obese children: the Leu72Met variant is associated with an earlier onset of obesity.

PubMed

Miraglia del Giudice, E; Santoro, N; Cirillo, G; Raimondo, P; Grandone, A; D'Aniello, A; Di Nardo, M; Perrone, L

2004-03-01

To test whether ghrelin variants could play a role in modulating some aspects of the obese phenotype during childhood. We screened the ghrelin gene in 300 Italian obese children and adolescents (mean age 10.5+/-3.2 y; range 4-19 y) and 200 controls by using the single-strand conformation polymorphism and the restriction fragment length polymoprhism analysis. No mutations were detected with the exception of two previously described polymorphisms, Arg51Gln and Leu72Met. For both variations, allelic frequencies were similar between patients and controls. Interestingly, we showed that the Leu72Met polymorphism was associated with differences in the age at obesity onset. Patients with the Met72 allele became obese earlier than homozygous patients for the wild Leu72 allele. The logrank test comparing the plots of the complement of Kaplan-Meier estimates between the two groups of patients was statistically significant (P<0.0001). It is unlikely that ghrelin variations cause the obesity due to single-gene mutations. The Leu72Met polymorphism of the ghrelin gene seems to play a role in anticipating the onset of obesity among children suggesting, therefore, that ghrelin may be involved in the pathophysiology of human adiposity.

Can Biannual Ultrasound Surveillance Detect Smaller Second Cancers or Detect Cancers Earlier in Patients with Breast Cancer History?

PubMed

You, Jai Kyung; Song, Mi Kyung; Kim, Min Jung; Kim, Eun-Kyung; Moon, Hee Jung; Youk, Ji Hyun; Yoon, Jung Hyun; Park, Vivian Youngjean; Park, Seho; Kim, Seung Il; Park, Byeong-Woo

2018-07-01

The aim of the work described here was to evaluate whether surveillance with biannual ultrasound (US) plus annual mammography (biannual group) for women with a history of breast cancer surgery results in earlier detection or in the detection of smaller second cancers than annual US plus mammography (annual group). Additionally, we compared the prevalence of distant metastases or palpable second cancers between the biannual and annual groups. The institutional review board of our institution approved this retrospective study, and patient consent was waived. Between January 2011 and December 2012, we retrospectively reviewed the clinical and imaging follow-up of 3023 patients with mammographic and US surveillance after breast cancer surgery to assess second cancers detected by local surveillance (locoregional recurrence, contralateral breast cancer or distant metastasis). The biannual and annual groups were divided with respect to the mean surveillance interval and compared with respect to clinicopathologic findings. Multivariable logistic regression with propensity score methods was used to examine the effect of the type of surveillance on outcomes. As for the size of the second cancer, no difference was seen between the biannual and annual groups (12.8 ± 6.6 mm vs. 14.1 ± 7.1 mm, p = 0.461); neither was there a significant difference between the groups in the presence of symptoms at the time of diagnosis of the second cancer (17.0% [8/47] vs. 10% [2/20], p = 0.711). Regardless of detection by local surveillance, the prevalence of distant metastases did not differ between the two groups (1.1% [27/2370] vs. 1.0% [7/653], p = 0.88) on univariate or multivariate analysis. The results of our retrospective study indicate that second cancers detected by biannual US surveillance in patients with a history of breast cancer surgery are not smaller and do not occur earlier than those detected by annual US surveillance. However, a randomized

Can social media data lead to earlier detection of drug‐related adverse events?

PubMed Central

Cremieux, Pierre; Audenrode, Marc Van; Vekeman, Francis; Karner, Paul; Zhang, Haimin; Greenberg, Paul

2016-01-01

Abstract Purpose To compare the patient characteristics and the inter‐temporal reporting patterns of adverse events (AEs) for atorvastatin (Lipitor®) and sibutramine (Meridia®) in social media (AskaPatient.com) versus the FDA Adverse Event Reporting System (FAERS). Methods We identified clinically important AEs associated with atorvastatin (muscle pain) and sibutramine (cardiovascular AEs), compared their patterns in social media postings versus FAERS and used Granger causality tests to assess whether social media postings were useful in forecasting FAERS reports. Results We analyzed 998 and 270 social media postings between 2001 and 2014, 69 003 and 7383 FAERS reports between 1997 and 2014 for atorvastatin and sibutramine, respectively. Social media reporters were younger (atorvastatin: 53.9 vs. 64.0 years, p < 0.001; sibutramine: 36.8 vs. 43.8 years, p < 0.001). Social media reviews contained fewer serious AEs (atorvastatin, pain: 2.5% vs. 38.2%; sibutramine, cardiovascular issues: 7.9% vs. 63.0%; p < 0.001 for both) and concentrated on fewer types of AEs (proportion comprising the top 20 AEs: atorvastatin, 88.7% vs. 55.4%; sibutramine, 86.3% vs. 65.4%) compared with FAERS. While social media sibutramine reviews mentioning cardiac issues helped predict those in FAERS 11 months later (p < 0.001), social media atorvastatin reviews did not help predict FAERS reports. Conclusions Social media AE reporters were younger and focused on less‐serious and fewer types of AEs than FAERS reporters. The potential for social media to provide earlier indications of AEs compared with FAERS is uncertain. Our findings highlight some of the promises and limitations of online social media versus conventional pharmacovigilance sources and the need for careful interpretation of the results. © 2016 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd. PMID:27601271

Can social media data lead to earlier detection of drug-related adverse events?

PubMed

Duh, Mei Sheng; Cremieux, Pierre; Audenrode, Marc Van; Vekeman, Francis; Karner, Paul; Zhang, Haimin; Greenberg, Paul

2016-12-01

To compare the patient characteristics and the inter-temporal reporting patterns of adverse events (AEs) for atorvastatin (Lipitor ® ) and sibutramine (Meridia ® ) in social media (AskaPatient.com) versus the FDA Adverse Event Reporting System (FAERS). We identified clinically important AEs associated with atorvastatin (muscle pain) and sibutramine (cardiovascular AEs), compared their patterns in social media postings versus FAERS and used Granger causality tests to assess whether social media postings were useful in forecasting FAERS reports. We analyzed 998 and 270 social media postings between 2001 and 2014, 69 003 and 7383 FAERS reports between 1997 and 2014 for atorvastatin and sibutramine, respectively. Social media reporters were younger (atorvastatin: 53.9 vs. 64.0 years, p < 0.001; sibutramine: 36.8 vs. 43.8 years, p < 0.001). Social media reviews contained fewer serious AEs (atorvastatin, pain: 2.5% vs. 38.2%; sibutramine, cardiovascular issues: 7.9% vs. 63.0%; p < 0.001 for both) and concentrated on fewer types of AEs (proportion comprising the top 20 AEs: atorvastatin, 88.7% vs. 55.4%; sibutramine, 86.3% vs. 65.4%) compared with FAERS. While social media sibutramine reviews mentioning cardiac issues helped predict those in FAERS 11 months later (p < 0.001), social media atorvastatin reviews did not help predict FAERS reports. Social media AE reporters were younger and focused on less-serious and fewer types of AEs than FAERS reporters. The potential for social media to provide earlier indications of AEs compared with FAERS is uncertain. Our findings highlight some of the promises and limitations of online social media versus conventional pharmacovigilance sources and the need for careful interpretation of the results. © 2016 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd. © 2016 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd.

Evolution and characterization of drought events from GRACE and other satellite and observation.

NASA Astrophysics Data System (ADS)

Zhao, M.; A, G.; Velicogna, I.; Kimball, J. S.

2015-12-01

We use GRACE Terrestrial Water Storage (TWS) changes to calculate a newly developed global drought severity index (GRACE-DSI) for monthly monitoring of water supply changes during 2002-2015. We compare GRACE-DSI with Palmer Drought Severity Index (PDSI) and other ancillary data to characterize drought timing, evolution and magnitude in the continental US since 2002. Overall GRACE-DSI and PDSI show an excellent correspondence in the US. However PDSI is very sensitive to atmospheric moisture stress, while GRACE-DSI only responds to changes in terrestrial water storage. We use the complementary nature of these two indices together with temperature and precipitation observations to characterize drought evolution and its nature. For instance, during the 2012 flash drought in the Great Plains, the PDSI decreases several months earlier than the GRACE-DSI in response to the enhanced atmosphere moisture demand caused by unusual early season warming. When the drought peaks later in the summer, the PDSI indicates exceptional drought, while the GRACE-DSI observes moderate drought conditions in the underlying total water supply, implying a meteorological drought in nature. GRACE-DSI is based solely on satellite observations; hence it has the advantage of not being affected by uncertainty associated with variable that are not well known at the global scale (e.g. precipitation estimates) and by biases associated to global climate model outputs. We find that GRACE-DSI captures major drought events in the globe occurring during 2002-2015, including those in sub-Sahara Africa, Australia, Amazon, Asia, North America and the Arctic.

OBSERVATIONS OF THE HIGH-MASS X-RAY BINARY A 0535+26 IN QUIESCENCE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rothschild, Richard; Markowitz, Alex; Hemphill, Paul

2013-06-10

We have analyzed three observations of the high-mass X-ray binary A 0535+26 performed by the Rossi X-Ray Timing Explorer (RXTE) three, five, and six months after the last outburst in 2011 February. We detect pulsations only in the second observation. The 3-20 keV spectra can be fit equally well with either an absorbed power law or absorbed thermal bremsstrahlung model. Reanalysis of two earlier RXTE observations made 4 yr after the 1994 outburst, original BeppoSAX observations 2 yr later, reanalysis of four EXOSAT observations made 2 yr after the last 1984 outburst, and a recent XMM-Newton observation in 2012 revealmore » a stacked, quiescent flux level decreasing from {approx}2 to <1 Multiplication-Sign 10{sup -11} erg cm{sup -2} s{sup -1} over 6.5 yr after outburst. The detection of pulsations during half of the quiescent observations would imply that accretion onto the magnetic poles of the neutron star continues despite the fact that the circumstellar disk may no longer be present. The accretion could come from material built up at the corotation radius or from an isotropic stellar wind.« less

The HepHIV 2017 Conference in Malta: joining forces for the earlier diagnosis of HIV and viral hepatitis.

PubMed

Raben, D; Hoekstra, M; Sperle, I; Amato Gauci, A J; Gauci, C; West, B; Sullivan, A; Lazarus, J V; Platteau, T; Rockstroh, J K

2018-02-01

The objective of the article is to provide an overview of the results of the HepHIV 2017 Conference organized by the HIV in Europe initiative under the Maltese EU Presidency in January 2017. A thourough review of all conference presentations (oral and poster presentations) was performed to retrieve the key outcomes of the conference. The key result from the conference was a call to action summarising key priorities in HIV and viral hepatitis testing and linkage to care. This included improving monitoring of viral hepatitis and HIV, mixing testing strategies and ensuring policy support. The important contribution and outcomes of EU funded projects OptTEST and EuroHIVEdat was highlighted. An integrated approach to earlier testing and linkage to care across diseases is needed in Europe and the HepHIV conferences create an important forum to reach this aim. © 2018 British HIV Association.

Earlier defibrotide initiation post-diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome improves Day +100 survival following haematopoietic stem cell transplantation.

PubMed

Richardson, Paul G; Smith, Angela R; Triplett, Brandon M; Kernan, Nancy A; Grupp, Stephan A; Antin, Joseph H; Lehmann, Leslie; Miloslavsky, Maja; Hume, Robin; Hannah, Alison L; Nejadnik, Bijan; Soiffer, Robert J

2017-07-01

Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a progressive, potentially fatal complication of conditioning for haematopoietic stem cell transplant (HSCT). The VOD/SOS pathophysiological cascade involves endothelial-cell activation and damage, and a prothrombotic-hypofibrinolytic state. Severe VOD/SOS (typically characterized by multi-organ dysfunction) may be associated with >80% mortality. Defibrotide is approved for treating severe hepatic VOD/SOS post-HSCT in the European Union, and for hepatic VOD/SOS with renal or pulmonary dysfunction post-HSCT in the United States. Previously, defibrotide (25 mg/kg/day in 4 divided doses for a recommended ≥21 days) was available through an expanded-access treatment protocol for patients with VOD/SOS. Data from this study were examined post-hoc to determine if the timing of defibrotide initiation post-VOD/SOS diagnosis affected Day +100 survival post-HSCT. Among 573 patients, defibrotide was started on the day of VOD/SOS diagnosis in approximately 30%, and within 7 days in >90%. The relationship between Day +100 survival and treatment initiation before/after specific days post-diagnosis showed superior survival when treatment was initiated closer to VOD/SOS diagnosis with a statistically significant trend over time for better outcomes with earlier treatment initiation (P < 0·001). These results suggest that initiation of defibrotide should not be delayed after diagnosis of VOD/SOS. © 2017 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd.

Observations of 1E 1740.7-2942 with ROSAT and the VLA

NASA Technical Reports Server (NTRS)

Heindl, William A.; Prince, Thomas A.; Grunsfeld, John M.

1994-01-01

We have observed the Galactic black hole candidate 1E 1740.7-2942 in X-rays with both the ROSAT HRI and PSPC and at 1.5 and 4.9 GHz with the VLA. From the HRI observation we derive a position for 1E 1740.7-2942 of right ascension = 17 h 43 m 54.9 s, declination = -29 deg 44 min 45.3 sec (J2000), with a 90% confidence error circle of radius 8.5 min. Thermal bremsstrahlung fits to the PSPC data yield a column density of 1.12+1.51/-0.18 x 10(exp 23)/sq cm, consistent with earlier X-ray measurements. The VLA observation of 4.9 GHz revealed two sources. Source A, which is the core of a double aligned radio jet source (Mirabel et al. 1992), lies within the ROSAT error circle, further confirming its identification with 1E 1740.7-2942.

Toroidal standing waves excited by a storm sudden commencement - DE 1 observations

NASA Technical Reports Server (NTRS)

Cahill, L. J., Jr.; Lin, N. G.; Engebretson, M. J.; Waite, J. H.; Sugiura, M.

1990-01-01

A 74-nT sudden commencement on July 13, 1982, was observed in the magnetosphere, with instruments on the Dynamics Explorer 1 satellite. Inbound, near L = 4.5, the satellite was located at 1524 magnetic local time and 20 deg magnetic latitude. The sudden commmencement established a strong, east-west oscillation, with 100-s period, which was observed in the magnetic field, the electric field, and the plasma flow velocity records. There was also a compressional component of this 100-s oscillation and a rapidly damped 300-s compressional pulsation. The compressional oscillations may be an evidence of cavity resonances, excited by the sudden commencement. The cavity waves may, in turn, couple to toroidal waves in field line resonance at the satellite location. In addition, the sudden commencement caused the onset of waves with frequencies from 0.1 up to at least 0.5 Hz. The observations are compared with similar reports from earlier pulsations related to sudden commencements.

Dental plaque development on a hydroxyapatite disk in young adults observed by using a barcoded pyrosequencing approach

PubMed Central

Takeshita, Toru; Yasui, Masaki; Shibata, Yukie; Furuta, Michiko; Saeki, Yoji; Eshima, Nobuoki; Yamashita, Yoshihisa

2015-01-01

Dental plaque is a dynamic microbial biofilm ecosystem that comprises hundreds of species including difficult-to-cultivate bacteria. We observed the assembly of a plaque bacterial community through 16S rRNA gene analysis. Plaque samples that accumulated on a hydroxyapatite disk for 1, 2, 3, 4, 5, and 7 days with saliva on day 0 were collected from 19 young adults using a removable resin splint. Quantitative PCR analysis showed that the total bacterial amount gradually increased and reached a plateau on day 4. Barcoded pyrosequencing analysis revealed that the microbial richness and diversity particularly increased between days 5 and 7. A principal coordinate analysis plot based on unweighted UniFrac showed the community assembly in a time-related manner, which became increasingly similar to the salivary microbiota. Facultative anaerobic bacteria such as Streptococcus, Neisseria, Abiotrophia, Gemella, and Rothia were predominant in the plaque bacterial community in the earlier days, whereas obligate anaerobes, such as Porphyromonas, Fusobacterium, Prevotella, and Capnocytophaga showed increased dominance on later days. UniFrac analysis also demonstrated that dental caries experience had a significant effect on the assembly process. Our results reveal the development pattern of the plaque bacterial community as well as the inter-individual differences associated with dental caries experience. PMID:25633431

Dental plaque development on a hydroxyapatite disk in young adults observed by using a barcoded pyrosequencing approach.

PubMed

Takeshita, Toru; Yasui, Masaki; Shibata, Yukie; Furuta, Michiko; Saeki, Yoji; Eshima, Nobuoki; Yamashita, Yoshihisa

2015-01-30

Dental plaque is a dynamic microbial biofilm ecosystem that comprises hundreds of species including difficult-to-cultivate bacteria. We observed the assembly of a plaque bacterial community through 16S rRNA gene analysis. Plaque samples that accumulated on a hydroxyapatite disk for 1, 2, 3, 4, 5, and 7 days with saliva on day 0 were collected from 19 young adults using a removable resin splint. Quantitative PCR analysis showed that the total bacterial amount gradually increased and reached a plateau on day 4. Barcoded pyrosequencing analysis revealed that the microbial richness and diversity particularly increased between days 5 and 7. A principal coordinate analysis plot based on unweighted UniFrac showed the community assembly in a time-related manner, which became increasingly similar to the salivary microbiota. Facultative anaerobic bacteria such as Streptococcus, Neisseria, Abiotrophia, Gemella, and Rothia were predominant in the plaque bacterial community in the earlier days, whereas obligate anaerobes, such as Porphyromonas, Fusobacterium, Prevotella, and Capnocytophaga showed increased dominance on later days. UniFrac analysis also demonstrated that dental caries experience had a significant effect on the assembly process. Our results reveal the development pattern of the plaque bacterial community as well as the inter-individual differences associated with dental caries experience.

Odessa Tsunami of 27 June 2014: Observations and Numerical Modelling

NASA Astrophysics Data System (ADS)

Šepić, Jadranka; Rabinovich, Alexander B.; Sytov, Victor N.

2018-04-01

On 27 June, a 1-2-m high wave struck the beaches of Odessa, the third largest Ukrainian city, and the neighbouring port-town Illichevsk (northwestern Black Sea). Throughout the day, prominent seiche oscillations were observed in several other ports of the Black Sea. Tsunamigenic synoptic conditions were found over the Black Sea, stretching from Romania in the west to the Crimean Peninsula in the east. Intense air pressure disturbances and convective thunderstorm clouds were associated with these conditions; right at the time of the event, a 1.5-hPa air pressure jump was recorded at Odessa and a few hours earlier in Romania. We have utilized a barotropic ocean numerical model to test two hypotheses: (1) a tsunami-like wave was generated by an air pressure disturbance propagating directly over Odessa ("Experiment 1"); (2) a tsunami-like wave was generated by an air pressure disturbance propagating offshore, approximately 200 km to the south of Odessa, and along the shelf break ("Experiment 2"). Both experiments decisively confirm the meteorological origin of the tsunami-like waves on the coast of Odessa and imply that intensified long ocean waves in this region were generated via the Proudman resonance mechanism while propagating over the northwestern Black Sea shelf. The "Odessa tsunami" of 27 June 2014 was identified as a "beach meteotsunami", similar to events regularly observed on the beaches of Florida, USA, but different from the "harbour meteotsunamis", which occurred 1-3 days earlier in Ciutadella (Baleares, Spain), Mazara del Vallo (Sicily, Italy) and Vela Luka (Croatia) in the Mediterranean Sea, despite that they were associated with the same atmospheric system moving over the Mediterranean/Black Sea region on 23-27 June 2014.

Latitudinal Variations Of The F3 Layer Observed From The SEALION Ionosonde Network

NASA Astrophysics Data System (ADS)

Uemoto, J.; Ono, T.; Maruyama, T.; Saito, S.; Iizima, M.; Kumamoto, A.

2006-12-01

[INTRODUCTION] The occurrence probability, local time, solar and magnetic activity dependences of the F3 layer have been clarified experimentally from ionosonde observations as well as model calculation, whereas some unexplained problems have remained; It has been reported that the F3 layer was frequently obrved in June solstice season at Fortaleza in Brazil (geographic latitude -4 deg, geographic longitude 322 deg, and dip latitude -5.4 deg) though in this season (local winter season), frequently occurrences of the F3 layer were not predicted from the model calculation with normal values of the E x B drift and meridional neutral wind and seasonal dependence of occurrences at Waltair (17.7 deg, 83.3 deg, 11.5 deg) shows a different tendency from that at Fortaleza. The latter problem seems to result from geographic control or differences of dip latitude between two observation locations, however, its physical mechanism has not been clarified. Then conjugate observations in a magnetic meridional plane are needed. For the purpose of clarifying the mechanism of the F3 layer in more detail, we are analyzing the ionosonde data of the South East Asian Low-latitude IOnosonde Network [SEALION] mainly provided by NiCT which consists of 4 ionosonde stations. In this study, we analyzed ionosonde data observed at Chiang Mai (CMU [18.8 deg, 98.9 deg, 13.0 deg]), Chumphon(CPN [10.7 deg, 99.4 deg, 3.3 deg]) and Kototabang (KTB [-0.2 deg, 100.3 deg, -10.0 deg]). [ANALYSIS] As a result from analyzing ionosonde data on 31st March, 2005, following dip latitudinal differences have been found; At CPN, in the vicinity of the dip equator, the F3 layer moved upward rapidly and disappeared in earlier local time, while at CMU and KTB, in the low dip latitude region, the F3 layer stayed at almost the same altitude and remained to be detectable with longer time duration. [CONCLUSION] From comparing between observation results and the model calculation, it is suggested that such a dip

Detection of Intrinsic Source Structure at ∼3 Schwarzschild Radii with Millimeter-VLBI Observations of SAGITTARIUS A*

NASA Astrophysics Data System (ADS)

Lu, Ru-Sen; Krichbaum, Thomas P.; Roy, Alan L.; Fish, Vincent L.; Doeleman, Sheperd S.; Johnson, Michael D.; Akiyama, Kazunori; Psaltis, Dimitrios; Alef, Walter; Asada, Keiichi; Beaudoin, Christopher; Bertarini, Alessandra; Blackburn, Lindy; Blundell, Ray; Bower, Geoffrey C.; Brinkerink, Christiaan; Broderick, Avery E.; Cappallo, Roger; Crew, Geoffrey B.; Dexter, Jason; Dexter, Matt; Falcke, Heino; Freund, Robert; Friberg, Per; Greer, Christopher H.; Gurwell, Mark A.; Ho, Paul T. P.; Honma, Mareki; Inoue, Makoto; Kim, Junhan; Lamb, James; Lindqvist, Michael; Macmahon, David; Marrone, Daniel P.; Martí-Vidal, Ivan; Menten, Karl M.; Moran, James M.; Nagar, Neil M.; Plambeck, Richard L.; Primiani, Rurik A.; Rogers, Alan E. E.; Ros, Eduardo; Rottmann, Helge; SooHoo, Jason; Spilker, Justin; Stone, Jordan; Strittmatter, Peter; Tilanus, Remo P. J.; Titus, Michael; Vertatschitsch, Laura; Wagner, Jan; Weintroub, Jonathan; Wright, Melvyn; Young, Ken H.; Zensus, J. Anton; Ziurys, Lucy M.

2018-05-01

We report results from very long baseline interferometric (VLBI) observations of the supermassive black hole in the Galactic center, Sgr A*, at 1.3 mm (230 GHz). The observations were performed in 2013 March using six VLBI stations in Hawaii, California, Arizona, and Chile. Compared to earlier observations, the addition of the APEX telescope in Chile almost doubles the longest baseline length in the array, provides additional uv coverage in the N–S direction, and leads to a spatial resolution of ∼30 μas (∼3 Schwarzschild radii) for Sgr A*. The source is detected even at the longest baselines with visibility amplitudes of ∼4%–13% of the total flux density. We argue that such flux densities cannot result from interstellar refractive scattering alone, but indicate the presence of compact intrinsic source structure on scales of ∼3 Schwarzschild radii. The measured nonzero closure phases rule out point-symmetric emission. We discuss our results in the context of simple geometric models that capture the basic characteristics and brightness distributions of disk- and jet-dominated models and show that both can reproduce the observed data. Common to these models are the brightness asymmetry, the orientation, and characteristic sizes, which are comparable to the expected size of the black hole shadow. Future 1.3 mm VLBI observations with an expanded array and better sensitivity will allow more detailed imaging of the horizon-scale structure and bear the potential for a deep insight into the physical processes at the black hole boundary.

Preflight studies on tolerance of pocket mice to oxygen and heat. IV - Observations on the brain

NASA Technical Reports Server (NTRS)

Bailey, O. T.; Ordy, J. M.; Haymaker, W.

1975-01-01

Experiments designed to ascertain the effects of oxygen at 8, 10, and 12 psi partial pressure on the brains of pocket mice (Perognathus longimembris) were carried out at room temperature (24 C, 75 F) and at 32 C (90 F). The animals exposed to 8-12 psi at 32 C had been in earlier KO2 oxygen tests. Five animals exposed either to 10 or 12 psi (517 mm or 620 mm Hg) O2 partial pressure at 32 C died during the course of the tests, possibly as a consequence of injury sustained by the earlier O2 partial pressure testing. Autopsy was not carried out. In the other 36 exposed animals, no pathological changes were observed in the brain. It is thus highly probable that oxygen pressures at the hyperbaric levels to which the pocket mice would be exposed during the Apollo XVII mission would not result in any lesions in the brain.

The Comoros Show the Earliest Austronesian Gene Flow into the Swahili Corridor.

PubMed

Brucato, Nicolas; Fernandes, Veronica; Mazières, Stéphane; Kusuma, Pradiptajati; Cox, Murray P; Ng'ang'a, Joseph Wainaina; Omar, Mohammed; Simeone-Senelle, Marie-Claude; Frassati, Coralie; Alshamali, Farida; Fin, Bertrand; Boland, Anne; Deleuze, Jean-Francois; Stoneking, Mark; Adelaar, Alexander; Crowther, Alison; Boivin, Nicole; Pereira, Luisa; Bailly, Pascal; Chiaroni, Jacques; Ricaut, François-Xavier

2018-01-04

At the dawn of the second millennium, the expansion of the Indian Ocean trading network aligned with the emergence of an outward-oriented community along the East African coast to create a cosmopolitan cultural and trading zone known as the Swahili Corridor. On the basis of analyses of new genome-wide genotyping data and uniparental data in 276 individuals from coastal Kenya and the Comoros islands, along with large-scale genetic datasets from the Indian Ocean rim, we reconstruct historical population dynamics to show that the Swahili Corridor is largely an eastern Bantu genetic continuum. Limited gene flows from the Middle East can be seen in Swahili and Comorian populations at dates corresponding to historically documented contacts. However, the main admixture event in southern insular populations, particularly Comorian and Malagasy groups, occurred with individuals from Island Southeast Asia as early as the 8 th century, reflecting an earlier dispersal from this region. Remarkably, our results support recent archaeological and linguistic evidence-based suggestions that the Comoros archipelago was the earliest location of contact between Austronesian and African populations in the Swahili Corridor. Copyright © 2017 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

Temporal Evolution of the Gamma-ray Burst Afterglow Spectrum for an Observer: GeV-TeV Synchrotron Self-Compton Light Curve

NASA Astrophysics Data System (ADS)

Fukushima, Takuma; To, Sho; Asano, Katsuaki; Fujita, Yutaka

2017-08-01

We numerically simulate the gamma-ray burst (GRB) afterglow emission with a one-zone time-dependent code. The temporal evolutions of the decelerating shocked shell and energy distributions of electrons and photons are consistently calculated. The photon spectrum and light curves for an observer are obtained taking into account the relativistic propagation of the shocked shell and the curvature of the emission surface. We find that the onset time of the afterglow is significantly earlier than the previous analytical estimate. The analytical formulae of the shock propagation and light curve for the radiative case are also different from our results. Our results show that even if the emission mechanism is switching from synchrotron to synchrotron self-Compton, the gamma-ray light curves can be a smooth power law, which agrees with the observed light curve and the late detection of a 32 GeV photon in GRB 130427A. The uncertainty of the model parameters obtained with the analytical formula is discussed, especially in connection with the closure relation between spectral index and decay index.

Does patient reporting lead to earlier detection of drug safety signals? A retrospective comparison of time to reporting between patients and healthcare professionals in a global database.

PubMed

Rolfes, Leàn; van Hunsel, Florence; Caster, Ola; Taavola, Henric; Taxis, Katja; van Puijenbroek, Eugène

2018-03-09

To explore if there is a difference between patients and healthcare professionals (HCPs) in time to reporting drug-adverse drug reaction (ADR) associations that led to drug safety signals. This was a retrospective comparison of time to reporting selected drug-ADR associations which led to drug safety signals between patients and HCPs. ADR reports were selected from the World Health Organization Global database of individual case safety reports, VigiBase. Reports were selected based on drug-ADR associations of actual drug safety signals. Primary outcome was the difference in time to reporting between patients and HCPs. The date of the first report for each individual signal was used as time zero. The difference in time between the date of the reports and time zero was calculated. Statistical differences in timing were analysed on the corresponding survival curves using a Mann-Whitney U test. In total, 2822 reports were included, of which 52.7% were patient reports, with a median of 25% for all included signals. For all signals, median time to signal detection was 10.4 years. Overall, HCPs reported earlier than patients: median 7.0 vs. 8.3 years (P < 0.001). Patients contributed a large proportion of reports on drug-ADR pairs that eventually became signals. HCPs reported 1.3 year earlier than patients. These findings strengthen the evidence on the value of patient reporting in signal detection and highlight an opportunity to encourage patients to report suspected ADRs even earlier in the future. © 2018 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

Pulse advancement and delay in an integrated-optical two-port ring-resonator circuit: direct experimental observations.

PubMed

Uranus, H P; Zhuang, L; Roeloffzen, C G H; Hoekstra, H J W M

2007-09-01

We report experimental observations of the negative-group-velocity (v(g)) phenomenon in an integrated-optical two-port ring-resonator circuit. We demonstrate that when the v(g) is negative, the (main) peak of output pulse appears earlier than the peak of a reference pulse, while for a positive v(g), the situation is the other way around. We observed that a pulse splitting phenomenon occurs in the neighborhood of the critical-coupling point. This pulse splitting limits the maximum achievable delay and advancement of a single device as well as facilitating a smooth transition from highly advanced to highly delayed pulse, and vice versa, across the critical-coupling point.

Observed near-surface flows under all tropical cyclone intensity levels using drifters in the northwestern Pacific

NASA Astrophysics Data System (ADS)

Chang, Yu-Chia; Chen, Guan-Yu; Tseng, Ruo-Shan; Centurioni, Luca R.; Chu, Peter C.

2013-05-01

Data from drifters of the surface velocity program and tropical cyclones (TCs) of the Joint Typhoon Warning Center during 1985-2009 were analyzed to demonstrate strong currents under various storm intensities such as category-4 to -5, category-2 to -3, and tropical storm to category-1 TCs in the northwestern Pacific. Current speeds over 2.0 m s-1 are observed under major TCs with the strongest mean currents to the right of the storm track. This study provides the characterization of the near-surface velocity response to all recorded TCs, and agrees roughly with Geisler's theory (1970). Our observations also verify earlier modeling results of Price (1983).

First Observations with the New Dual Sphere Superconducting Gravimeter Osg-073 at Metsähovi, Finland

NASA Astrophysics Data System (ADS)

Virtanen, H.; Raja-Halli, A.; Bilker-Koivula, M.; Naranen, J.; Ruotsalainen, H. E. O.

2014-12-01

The new dual sphere superconducting gravimeter (SG) OSG-073 was installed in the Metsähovi Geodetic Observatory in February 2014. Its two gravity sensors are side by side, not one on top of another as in most earlier dual sensor installations. One sensor is the standard iGrav™ SG, with a lightweight sphere (5 grams) which is nearly drift-free. The second sensor uses a heavy 20-gram sphere which gives ultra low noise and a much higher quality factor Q. We present time domain observations of the first months, and estimate drift rates after the initial exponential drift. We have determined the transfer functions. Calibration factors were obtained using parallel registrations with the FG5X-221 absolute gravimeter of the FGI. We show selected free oscillation spectra from the SG, and seismic data obtained at Metsähovi with the Nanometrics Trillium 120P broadband seismometer of the Institute of Seismology (University of Helsinki). The noise level of the data is then compared with the New Low Noise Model NLNM. The results with the dual sphere SG can be compared with parallel observations with the SG T020. This 20-year old instrument is situated in the same room at a distance of 2 metres from the dual-sphere SG.

Epidemiological Data Management during an Outbreak of Ebola Virus Disease: Key Issues and Observations from Sierra Leone.

PubMed

Owada, Kei; Eckmanns, Tim; Kamara, Kande-Bure O'Bai; Olu, Olushayo Oluseun

2016-01-01

Sierra Leone experienced intense transmission of Ebola virus disease (EVD) from May 2014 to November 2015 during which a total of 8,704 confirmed cases and over 3,589 confirmed deaths were reported. Our field observation showed many issues in the EVD data management system, which may have contributed to the magnitude and long duration of the outbreak. In this perspective article, we explain the key issues with EVD data management in the field, and the resulting obstacles in analyzing key epidemiological indicators during the outbreak response work. Our observation showed that, during the latter part of the EVD outbreak, surveillance and data management improved at all levels in the country as compared to the earlier stage. We identified incomplete filling and late arrival of the case investigation forms at data management centers, difficulties in detecting double entries and merging identified double entries in the database, and lack of clear process of how death of confirmed cases in holding, treatment, and community care centers are reported to the data centers as some of challenges to effective data management. Furthermore, there was no consolidated database that captured and linked all data sources in a structured way. We propose development of a new application tool easily adaptable to new occurrences, regular data harmonization meetings between national and district data management teams, and establishment of a data quality audit system to assure good quality data as ways to improve EVD data management during future outbreaks.

Observations of the Merging of Two Quiescent Filaments

NASA Astrophysics Data System (ADS)

Mikurda, Katarzyna; Martin, S. F.

2007-05-01

The two filaments were observed close to disk center in the same field of view of approximately 9x9 arc. min. The observations were made using a tunable lithium niobate, narrow band etalon on the 25 cm Martin Solar Telescope at Helio Research in southern California. One filament was close to the equator and was oriented nearly east-west and the other, to the west, was oriented north-south with the north end approximately 120 Mm from the west end of the equatorial filament. Continued observations were made of these filaments for 2 to 5.5 hours per day between October 10 and 15, 2004. The observations were made at multiple wavelengths within + and - 1 Å around Hα. We compared Hα centerline images with data taken by SOHO/EIT at 304A and observed significant differences in the evolution of the filaments at these wavelengths. For example, in EIT 304 Å images the two filaments seem to join on October 12, i.e. about two days earlier than in Hα. Moreover, the observed merging took longer (over three days) in Hα than in EIT 304 Å images, where it took place on a single day. The dynamics of the merger event is demonstrated with Hα and EIT 304 Å movies. The Doppler velocities calculated from the line wings images before, during and after the merging event were in the normal range for quiescent filaments. In our investigation of subsequent SOHO/EIT images at 304 Å we found no sign of an eruption due to the merging of the filaments. The contribution of KM was supported under NASA grant NAG5-10852 and SFM acknowledges NSF grant ATM-0519249.

VLBI observations of the nucleus of Centaurus A

NASA Technical Reports Server (NTRS)

Preston, R. A.; Wehrle, A. E.; Morabito, D. D.; Jauncey, D. L.; Batty, M. J.; Haynes, R. F.; Wright, A. E.; Nicolson, G. D.

1983-01-01

VLBI observations of the nucleus of Centaurus A made at 2.3 GHz on baselines with minimum fringe spacings of 0.15 and 0.0027 arcsec are presented. Results show that the nuclear component is elongated with a maximum extent of approximately 0.05 arcsec which is equivalent to a size of approximately 1 pc at the 5 Mpc distance of Centaurus A. The position angle of the nucleus is found to be 30 + or - 20 degrees, while the ratio of nuclear jet length to width is less than or approximately equal to 20. The nuclear flux density is determined to be 6.8 Jy, while no core component is found with an extent less than or approximately equal to 0.001 (less than or approximately equal to 0.02 pc) with a flux density of greater than or approximately equal to 20 mJy. A model of the Centaurus A nucleus composed of at least two components is developed on the basis of these results in conjunction with earlier VLBI and spectral data. The first component is an elongated source of approximately 0.05 arcsec (approximately 1 pc) size which contains most of the 2.3 GHz nuclear flux, while the second component is a source of approximately 0.0005 arcsec (approximately 0.01 pc) size which is nearly completely self-absorbed at 2.3 GHz but strengthens at higher frequencies.

Combining in Vitro Diagnostics with in Vivo Imaging for Earlier Detection of Pancreatic Ductal Adenocarcinoma: Challenges and Solutions

PubMed Central

Laeseke, Paul F.; Chen, Ru; Jeffrey, R. Brooke; Brentnall, Teresa A.

2015-01-01

Pancreatic ductal adenocarcinoma (PDAC) is the fourth-leading cause of cancer-related death in the United States and is associated with a dismal prognosis, particularly when diagnosed at an advanced stage. Overall survival is significantly improved if PDAC is detected at an early stage prior to the onset of symptoms. At present, there is no suitable screening strategy for the general population. Available diagnostic serum markers are not sensitive or specific enough, and clinically available imaging modalities are inadequate for visualizing early-stage lesions. In this article, the role of currently available blood biomarkers and imaging tests for the early detection of PDAC will be reviewed. Also, the emerging biomarkers and molecularly targeted imaging agents being developed to improve the specificity of current imaging modalities for PDAC will be discussed. A strategy incorporating blood biomarkers and molecularly targeted imaging agents could lead to improved screening and earlier detection of PDAC in the future. © RSNA, 2015 PMID:26599925

Four Years of Venus Express Magnetic Field Observations: Variable Bow Shock Location and Other Features

NASA Astrophysics Data System (ADS)

Zhang, Tielong; Baumjohann, Wolfgang; Russell, C. T.

Since the Venus Express insertion into a highly elliptical polar orbit with a period of 24 h around the planet Venus, the magnetometer has operated continuously for about 4 years and obtained a wealth of data in the solar minimum at rather low altitude, which was not reached by earlier missions. In this paper, we review the magnetic field observations by Venus Express emphasizing on the variable bow shock location and other space environment features such as the magnetic barrier and the magnetotail.

Verbal abuse, like physical and sexual abuse, in childhood is associated with an earlier onset and more difficult course of bipolar disorder.

PubMed

Post, Robert M; Altshuler, Lori L; Kupka, Ralph; McElroy, Susan L; Frye, Mark A; Rowe, Michael; Leverich, Gabriele S; Grunze, Heinz; Suppes, Trisha; Keck, Paul E; Nolen, Willem A

2015-05-01

Physical or sexual abuse in childhood is known to have an adverse effect on the course of bipolar disorder, but the impact of verbal abuse has not been well elucidated. We examined the occurrence and frequency (never to frequently) of each type of abuse in childhood in 634 US adult outpatients (average age 40 years). Patients gave informed consent and provided information about their age of onset and course of illness prior to study entry. Verbal abuse alone occurred in 24% of the patients. Similar to a history of physical or sexual abuse, a history of verbal abuse was related to an earlier age of onset of bipolar disorder and other poor prognosis characteristics, including anxiety and substance abuse comorbidity, rapid cycling, and a deteriorating illness course as reflected in ratings of increasing frequency or severity of mania and depression. A lasting adverse impact of the experience of verbal abuse in childhood is suggested by its relationship to an earlier age of onset of bipolar disorder, other poor prognosis factors, and a deteriorating course of illness. Verbal abuse is a common confound in comparison groups defined by a lack of physical or sexual abuse. Ameliorating the impact of verbal abuse on the unfolding course of bipolar disorder appears to be an important target of therapeutics and worthy of attempts at primary and secondary prophylaxis. Family-based treatments that focus on psychoeducation, enhancing intra-family communication, and coping skills may be particularly helpful. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy

PubMed Central

Aqbi, Hussein F.; Tyutyunyk-Massey, Liliya; Keim, Rebecca C.; Butler, Savannah E.; Thekkudan, Theresa; Joshi, Supriya; Smith, Timothy M.; Bandyopadhyay, Dipankar; Idowu, Michael O.; Bear, Harry D.; Payne, Kyle K.; Gewirtz, David A.; Manjili, Masoud H.

2018-01-01

Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse earlier than others. In addition, some tumor clones respond to immunotherapy while others do not. We investigated how autophagy plays a role in accelerating or delaying recurrence of neu-overexpressing mouse mammary carcinoma (MMC) following adriamycin (ADR) treatment, and in affecting response to immunotherapy. We explored two strategies: 1) transient blockade of autophagy with chloroquine (CQ), which blocks fusion of autophagosomes and lysosomes during ADR treatment, and 2) permanent inhibition of autophagy by a stable knockdown of ATG5 (ATG5KD), which inhibits the formation of autophagosomes in MMC during and after ADR treatment. We found that while CQ prolonged tumor dormancy, but that stable knockdown of autophagy resulted in early escape from dormancy and recurrence. Interestingly, ATG5KD MMC contained an increased frequency of ADR-induced polyploid-like cells and rendered MMC resistant to immunotherapy. On the other hand, a transient blockade of autophagy did not affect the sensitivity of MMC to immunotherapy. Our observations suggest that while chemotherapy-induced autophagy may facilitate tumor relapse, cell-intrinsic autophagy delays tumor relapse, in part, by inhibiting the formation of polyploid-like tumor dormancy. PMID:29774126

4. VIEW SOUTHWEST COMPONENTS TEST LAB TEST BAY DETAIL SHOWING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. VIEW SOUTHWEST COMPONENTS TEST LAB TEST BAY DETAIL SHOWING EMERGENCY SHOWER, AND EYEWASH, AND OBSERVATION WINDOW. STORAGE TANKS ON ROOF. - Marshall Space Flight Center, East Test Area, Components Test Laboratory, Huntsville, Madison County, AL

Earlier saccades to task-relevant targets irrespective of relative gain between peripheral and foveal information.

PubMed

Wolf, Christian; Schütz, Alexander C

2017-06-01

Saccades bring objects of interest onto the fovea for high-acuity processing. Saccades to rewarded targets show shorter latencies that correlate negatively with expected motivational value. Shorter latencies are also observed when the saccade target is relevant for a perceptual discrimination task. Here we tested whether saccade preparation is equally influenced by informational value as it is by motivational value. We defined informational value as the probability that information is task-relevant times the ratio between postsaccadic foveal and presaccadic peripheral discriminability. Using a gaze-contingent display, we independently manipulated peripheral and foveal discriminability of the saccade target. Latencies of saccades with perceptual task were reduced by 36 ms in general, but they were not modulated by the information saccades provide (Experiments 1 and 2). However, latencies showed a clear negative linear correlation with the probability that the target is task-relevant (Experiment 3). We replicated that the facilitation by a perceptual task is spatially specific and not due to generally heightened arousal (Experiment 4). Finally, the facilitation only emerged when the perceptual task is in the visual but not in the auditory modality (Experiment 5). Taken together, these results suggest that saccade latencies are not equally modulated by informational value as by motivational value. The facilitation by a perceptual task only arises when task-relevant visual information is foveated, irrespective of whether the foveation is useful or not.

Reduction of EAO Positional Observations Database

NASA Astrophysics Data System (ADS)

Nefedyev, Yuri; Andreev, Alexey; Demina, Natalya; Churkin, Konstantin

2016-07-01

There is a large data bank of positional observations of Solar System bodies at Engelhadt Astronomical Observatory (EAO). The positional observations include the major planets, except Jupiter. Modern technologies replace classical methods of observations in astronomy and in astrometry as well. At the same time many positional observations have been gathered at astronomical observatories. So taking into account that observations of the past epochs have presenteda great value for astronomy and as times goes by their importance is growing it is obvious that positional astrometry will not lose its practical importance. This was noted in B3 XXIV IAU resolution by the General Assembly. The results of reduction of solar system bodies observations were published mainly in Proceeding of EAO and Transactions of Kazan City Astronomical Observatory. Earlier there have been made about three thousand observations at EAO and Zelenchuk station with the Zeiss telescope (D=400mm, f=2000mm), AFR-18 (photo visual, D=200, f=2000), refractor (D=400mm, f=3450mm), Meniscus camera (D=340mm, f=1200mm), Schmidt camera (D=350mm, f=2000mm). The major planets except Pluto and Neptune were observed with a special cassette chamber equipped with a rotating disk which had an open sector to reduce the brightness of the planets. The dimension of the sector was chosen accordingto the brightness of the planets. The disk was placed in the centre of the astrograph's field. The stars' true brightness was preserved. A large number of catalogues were compiled by the end of the 20th century. We used Tycho-2 catalogue for reducing our observations. As it is known the catalogue Tycho-2 (Tycho-2 catalogue, 2000) includes 2539913 stars. The stars' proper motions given in the catalogue were obtained by comparing positions from Tycho-2 with positions from the Astrographic Catalogue. Therefore they are considered to be highly accurate. The accuracy of stellar positions in Tycho-2 is about 60 mas and the accuracy of

Rocket observation of soft energetic particles at the magnetic equator

NASA Technical Reports Server (NTRS)

Goldberg, R. A.

1974-01-01

Results from a rocket-borne ion mass spectrometer flown near the magnetic equator at 0108 LMT, March 10, 1970, exhibit an unusual background current above 200 km. This current is observed to increase 3.5 orders of magnitude between 200 and 260 km before maximizing to a fixed value from 260 km to the 295 km apogee of the flight. Properties of the background combined with laboratory measurements have permitted probable identification of the background source as 2-20 keV electrons or protons. Maximum electron fluxes have been estimated to be of the order 10 to the 10th power particles/sq cm-sec-ster in accord with ISIS-1 satellite measurements at higher altitudes. The background was not observed on an earlier flight at 1938 LMT, suggesting the particles to be trapped in a blet which drifted below 300 km between the two flights. The low altitude penetration of these fluxes may have been related to the great magnetic storm of March 8. Simultaneous measurements of the thermal ion distribution are compared with these results and qualitatively suggest that the soft energetic particles are responsible for an observed O2(+) and NO(+) enhancement.

Cholesteatoma has a high prevalence in Turner syndrome, highlighting the need for earlier diagnosis and the potential benefits of otoscopy training for paediatricians.

PubMed

Lim, D B N; Gault, E J; Kubba, H; Morrissey, M S C; Wynne, D M; Donaldson, M D C

2014-07-01

Girls with Turner syndrome are prone to cholesteatoma, a serious suppurative middle ear disease. We aimed to confirm its high prevalence in Turner syndrome, identify risk factors and suggest possible strategies for earlier detection. We reviewed 179 girls with Turner syndrome between 1989 and 2012 to identify cases of cholesteatoma. Seven girls (3.9%) had cholesteatoma (index girls) and each was compared with three age-matched girls without cholesteatoma (comparison girls). All the index girls had either the 45,X or 45,X/46X,i(Xq) karyotypes. Nine ears were initially affected, with three recurrences in two girls. Median age at first cholesteatoma presentation was 11.9 years (range: 7.5-15.2), with otorrhoea for three (range: one to seven) months in all 12 affected ears. Index girls had a significantly higher proportion of previous recurrent acute (p = 0.007) and chronic otitis media (p = 0.008), chronic perforation (p = 0.038) aural polyps (p < 0.0001) and tympanic membrane retraction (p = 0.0001) than comparison girls. Cholesteatoma has a high prevalence in Turner syndrome. Risk factors include 45,X and 46,XiXq karyotypes; a history of chronic otitis media, tympanic membrane retraction and persistent otorrhoea; and older age. Earlier recognition of ear disease is needed and otoscopy training for paediatricians caring for Turner syndrome patients may be beneficial. ©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

SOUTHWEST REAR, SHOWING CLOSED ENTRY HATCH, BUILDING 1934. Looking north ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SOUTHWEST REAR, SHOWING CLOSED ENTRY HATCH, BUILDING 1934. Looking north - Edwards Air Force Base, X-15 Engine Test Complex, Observation Bunker Types, Rogers Dry Lake, east of runway between North Base & South Base, Boron, Kern County, CA

Earlier surgical intervention in congenital heart disease results in better outcome and resource utilization.

PubMed

Panni, Roheena Z; Ashfaq, Awais; Amanullah, Muhammad M

2011-12-29

Congenital heart disease (CHD) accounts for a major proportion of disease in the pediatric age group. The objective of the study was to estimate the cost of illness associated with CHD pre, intra and postoperatively; among patients referred to a tertiary care hospital in Karachi, Pakistan. This is the first study conducted to estimate the cost of managing CHD in Pakistan. A prevalence based cost of illness study design was used to estimate the cost of cardiac surgery (corrective & palliative) for congenital heart defects in children ≤ 5 years of age from June 2006 to June 2009. A total of 120 patients were enrolled after obtaining an informed consent and the data was collected using a pre-tested questionnaire. The mean age at the time of surgery in group A (1-12 mo age) was 6.08 ± 2.80 months and in group B (1-5 yrs) was 37.10 ± 19.94 months. The cost of surgical admission was found to be significantly higher in the older group, p = 0.001. The total number and cost of post-operative outpatient visits was also higher in group B, p = 0.003. Pre and post operative hospital admissions were not found to be significantly different among the two groups, p = 0.166 and 0.627, respectively. The number of complications were found to be different between the two groups (p = 0.019). Majority of these were contributed by hemorrhage and post-operative seizures. This study concluded that significant expenditure is incurred by people with CHD; with the implication that resources could be saved by earlier detection and awareness campaigns.

Phylogenomic analysis of Copepoda (Arthropoda, Crustacea) reveals unexpected similarities with earlier proposed morphological phylogenies.

PubMed

Eyun, Seong-Il

2017-01-19

Copepods play a critical role in marine ecosystems but have been poorly investigated in phylogenetic studies. Morphological evidence supports the monophyly of copepods, whereas interordinal relationships continue to be debated. In particular, the phylogenetic position of the order Harpacticoida is still ambiguous and inconsistent among studies. Until now, a small number of molecular studies have been done using only a limited number or even partial genes and thus there is so far no consensus at the order-level. This study attempted to resolve phylogenetic relationships among and within four major copepod orders including Harpacticoida and the phylogenetic position of Copepoda among five other crustacean groups (Anostraca, Cladocera, Sessilia, Amphipoda, and Decapoda) using 24 nuclear protein-coding genes. Phylogenomics has confirmed the monophyly of Copepoda and Podoplea. However, this study reveals surprising differences with the majority of the copepod phylogenies and unexpected similarities with postembryonic characters and earlier proposed morphological phylogenies; More precisely, Cyclopoida is more closely related to Siphonostomatoida than to Harpacticoida which is likely the most basally-branching group of Podoplea. Divergence time estimation suggests that the origin of Harpacticoida can be traced back to the Devonian, corresponding well with recently discovered fossil evidence. Copepoda has a close affinity to the clade of Malacostraca and Thecostraca but not to Branchiopoda. This result supports the hypothesis of the newly proposed clades, Communostraca, Multicrustacea, and Allotriocarida but further challenges the validity of Hexanauplia and Vericrustacea. The first phylogenomic study of Copepoda provides new insights into taxonomic relationships and represents a valuable resource that improves our understanding of copepod evolution and their wide range of ecological adaptations.

Aeolian drift sand archives show evidence of Late Holocene groundwater dynamics in NE Belgium

NASA Astrophysics Data System (ADS)

Beerten, Koen

2017-04-01

The sandy unconfined aquifers of NE Belgium (Kleine Nete catchment, Campine area) underlay a flat and slightly undulating landscape. It is drained by small rivers that occupy shallow valleys separated by weakly expressed interfluves. Instrumental time series (collected since the 1980s) show that the mean highest groundwater table (MHG) on these interfluves (late winter - early spring) is generally 1-2 m below the surface. For earlier periods there are no systematic observations of groundwater tables in the area. Such information would allow to extend the time window for hydrological model validation and verification under different boundary conditions (soil, land-use, climate) and thus build confidence in future hydrological predictions. The sandy interfluves of the Kleine Nete catchment have witnessed strong aeolian morphodynamics during the last few millenia. Many of the podzols that developed during the Holocene became either eroded by wind deflation or buried under drift sand. This situation provides a unique means to study palaeohydrological features, events and processes in such shallow unsaturated zones. Therefore, the aim of this presentation is to explore the potential of pedological, geomorphological and historical archives from drift sand landscapes in the Campine area as proxies for past groundwater tables. The adopted approach includes a wide variety of techniques, such as field descriptions of palaeosol profile morphology, optically stimulated luminescence (OSL) dating of intercalated drift sands, determination of groundwater-controlled blow-out surfaces and observations of surface water bodies on historical maps. The buried podzols often display hydromorphic properties, such as redoximorphic features, vague horizon boundaries and peat development. OSL dating of associated drift sands suggests that a very shallow MHG existed from ca. 6 ka until at least ca. 2 ka. Subsequently, historical maps suggest that groundwater tables started to decline during

The 2016 Transit of Mercury Observed from Major Solar Telescopes and Satellites

NASA Astrophysics Data System (ADS)

Pasachoff, Jay M.; Schneider, Glenn; Gary, Dale; Chen, Bin; Sterling, Alphonse C.; Reardon, Kevin P.; Dantowitz, Ronald; Kopp, Greg A.

2016-10-01

We report observations from the ground and space of the 9 May 2016 transit of Mercury. We build on our explanation of the black-drop effect in transits of Venus based on spacecraft observations of the 1999 transit of Mercury (Schneider, Pasachoff, and Golub, Icarus 168, 249, 2004). In 2016, we used the 1.6-m New Solar Telescope at the Big Bear Solar Observatory with active optics to observe Mercury's transit at high spatial resolution. We again saw a small black-drop effect as 3rd contact neared, confirming the data that led to our earlier explanation as a confluence of the point-spread function and the extreme solar limb darkening (Pasachoff, Schneider, and Golub, in IAU Colloq. 196, 2004). We again used IBIS on the Dunn Solar Telescope of the Sacramento Peak Observatory, as A. Potter continued his observations, previously made at the 2006 transit of Mercury, at both telescopes of the sodium exosphere of Mercury (Potter, Killen, Reardon, and Bida, Icarus 226, 172, 2013). We imaged the transit with IBIS as well as with two RED Epic IMAX-quality cameras alongside it, one with a narrow passband. We show animations of our high-resolution ground-based observations along with observations from XRT on JAXA's Hinode and from NASA's Solar Dynamics Observatory. Further, we report on the limit of the transit change in the Total Solar Irradiance, continuing our interest from the transit of Venus TSI (Schneider, Pasachoff, and Willson, ApJ 641, 565, 2006; Pasachoff, Schneider, and Willson, AAS 2005), using NASA's SORCE/TIM and the Air Force's TCTE/TIM. See http://transitofvenus.info and http://nicmosis.as.arizona.edu.Acknowledgments: We were glad for the collaboration at Big Bear of Claude Plymate and his colleagues of the staff of the Big Bear Solar Observatory. We also appreciate the collaboration on the transit studies of Robert Lucas (Sydney, Australia) and Evan Zucker (San Diego, California). JMP appreciates the sabbatical hospitality of the Division of Geosciences and

Thermal effects of groundwater flow through subarctic fens: A case study based on field observations and numerical modeling

DOE PAGES

Sjöberg, Ylva; Coon, Ethan; K. Sannel, A. Britta; ...

2016-02-04

Modeling and observation of ground temperature dynamics are the main tools for understanding current permafrost thermal regimes and projecting future thaw. Until recently, most studies on permafrost have focused on vertical ground heat fluxes. Groundwater can transport heat in both lateral and vertical directions but its influence on ground temperatures at local scales in permafrost environments is not well understood. In this paper, we combine field observations from a subarctic fen in the sporadic permafrost zone with numerical simulations of coupled water and thermal fluxes. At the Tavvavuoma study site in northern Sweden, ground temperature profiles and groundwater levels weremore » observed in boreholes. These observations were used to set up one- and two-dimensional simulations down to 2 m depth across a gradient of permafrost conditions within and surrounding the fen. Two-dimensional scenarios representing the fen under various hydraulic gradients were developed to quantify the influence of groundwater flow on ground temperature. Our observations suggest that lateral groundwater flow significantly affects ground temperatures. This is corroborated by modeling results that show seasonal ground ice melts 1 month earlier when a lateral groundwater flux is present. Further, although the thermal regime may be dominated by vertically conducted heat fluxes during most of the year, isolated high groundwater flow rate events such as the spring freshet are potentially important for ground temperatures. Finally, as sporadic permafrost environments often contain substantial portions of unfrozen ground with active groundwater flow paths, knowledge of this heat transport mechanism is important for understanding permafrost dynamics in these environments.« less

Star Shows It Has The Right Stuff

NASA Astrophysics Data System (ADS)

2004-01-01

Astronomers have used an observation by NASA's Chandra X-ray Observatory to make the best case yet that a star can be engulfed by its companion star and survive. This discovery will help astronomers better understand how closely coupled stars, and perhaps even stars and planets, evolve when one of the stars expands enormously in its red giant phase. The binary star system known as V471 Tauri comprises a white dwarf star (the primary) in a close orbit -- one thirtieth of the distance between Mercury and the Sun -- with a normal Sun-like star (the secondary). Chandra's data showed that the hot upper atmosphere of the secondary star has a deficit of carbon atoms relative to nitrogen atoms. "This deficit of carbon atoms is the first clear observational evidence that the normal star was engulfed by its companion in the past," according to Jeremy Drake of the Smithsonian Astrophysical Observatory in Cambridge, MA, who coauthored an article on V471 in The Astrophysical Journal Letters with Marek Sarna of the N. Copernicus Astronomical Center in Poland. The white dwarf star was once a star several times as massive as the Sun. Nuclear fusion reactions in the core of such a star convert carbon into nitrogen over a period of about a billion years. When the fuel in the core of the star is exhausted, the core collapses, triggering more energetic nuclear reactions that cause the star to expand and transform into a red giant before eventually collapsing to become a white dwarf. The carbon-poor material in the core of the red giant is mixed with outer part of the star, so its atmosphere shows a deficit of carbon, as compared with Sun-like stars. The X-ray spectra of a red giant star (top panel) and a Sun-like star (bottom panel) show the large difference in the peaks due to carbon atoms in the two stars. Theoretical calculations indicate that a red giant in a binary system can completely envelop its companion star and dramatically affect its evolution. During this common envelope

Resolved Companions of Cepheids: Testing the Candidates with X-Ray Observations

NASA Astrophysics Data System (ADS)

Evans, Nancy Remage; Pillitteri, Ignazio; Wolk, Scott; Karovska, Margarita; Tingle, Evan; Guinan, Edward; Engle, Scott; Bond, Howard E.; Schaefer, Gail H.; Mason, Brian D.

2016-04-01

We have made XMM-Newton observations of 14 Galactic Cepheids that have candidate resolved (≥5″) companion stars based on our earlier HST Wide Field Camera 3 (WFC3) imaging survey. Main-sequence stars that are young enough to be physical companions of Cepheids are expected to be strong X-ray producers in contrast to field stars. XMM-Newton exposures were set to detect essentially all companions hotter than spectral type M0 (corresponding to 0.5 M⊙). The large majority of our candidate companions were not detected in X-rays, and hence are not confirmed as young companions. One resolved candidate (S Nor #4) was unambiguously detected, but the Cepheid is a member of a populous cluster. For this reason, it is likely that S Nor #4 is a cluster member rather than a gravitationally bound companion. Two further Cepheids (S Mus and R Cru) have X-ray emission that might be produced by either the Cepheid or the candidate resolved companion. A subsequent Chandra observation of S Mus shows that the X-rays are at the location of the Cepheid/spectroscopic binary. R Cru and also V659 Cen (also X-ray bright) have possible companions closer than 5″ (the limit for this study) which are the likely sources of X-rays. One final X-ray detection (V473 Lyr) has no known optical companion, so the prime suspect is the Cepheid itself. It is a unique Cepheid with a variable amplitude. The 14 stars that we observed with XMM constitute 36% of the 39 Cepheids found to have candidate companions in our HST/WFC3 optical survey. No young probable binary companions were found with separations of ≥5″ or 4000 au. Based on observations obtained with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA Member States and the USA (NASA).

New observations of molecular nitrogen in the Martian upper atmosphere by IUVS on MAVEN

NASA Astrophysics Data System (ADS)

Stevens, M. H.; Evans, J. S.; Schneider, N. M.; Stewart, A. I. F.; Deighan, J.; Jain, S. K.; Crismani, M.; Stiepen, A.; Chaffin, M. S.; McClintock, W. E.; Holsclaw, G. M.; Lefèvre, F.; Lo, D. Y.; Clarke, J. T.; Montmessin, F.; Bougher, S. W.; Jakosky, B. M.

2015-11-01

We identify molecular nitrogen (N2) emissions in the Martian upper atmosphere using the Imaging Ultraviolet Spectrograph (IUVS) on NASA's Mars Atmosphere and Volatile EvolutioN (MAVEN) mission. We report the first observations of the N2 Lyman-Birge-Hopfield (LBH) bands at Mars and confirm the tentative identification of the N2 Vegard-Kaplan (VK) bands. We retrieve N2 density profiles from the VK limb emissions and compare calculated limb radiances between 90 and 210 km against both observations and predictions from a Mars general circulation model (GCM). Contrary to earlier analyses using other satellite data, we find that N2 abundances exceed GCM results by about a factor of 2 at 130 km but are in agreement at 150 km. The analysis and interpretation are enabled by a linear regression method used to extract components of UV spectra from IUVS limb observations.

History of Satellite Observations of East Pacific Atmospheric Rivers

NASA Astrophysics Data System (ADS)

Vonder Haar, T. H.; Forsythe, J. M.; Seaman, C.

2017-12-01

The terms "Atmospheric River" or "Tropospheric River" were not used in refereed literature until the 1990's, although earlier works hinted at the existence of narrow corridors of moisture transport. With the advent of satellite observations in the 1960's, meteorologists began to discover the fingerprints of these phenomena via cloud observations. Early geostationary satellites depicted "cloud rivers" or "pipeline cirrus" impacting the U.S. west coast, with only indirect evidence of large water vapor transport. Routine use of passive microwave imagery to retrieve total column water vapor began in the late 1980's with the launch of the Special Sensor Microwave / Imager instrument, whose descendants continue to provide realtime monitoring of atmospheric rivers today. Passive microwave data opened the door to quantitative studies of atmospheric rivers, by providing the water vapor measurements needed to compute integrated moisture flux. Atmospheric rivers are detected in near-realtime from passive microwave water vapor products. In recent years, dedicated coastal observatories, multidecadal global water vapor data sets, cloud radars, and satellite sounding systems have begun to probe the 4-dimensional moisture structure of atmospheric rivers. The timeline of our understanding of atmospheric rivers will be presented from the standpoint of evolving satellite observing systems.

Near-Earth Asteroid Physical Observations: 1993-1995

NASA Astrophysics Data System (ADS)

Skiff, B. A.; Buie, M. W.; Bowell, E.

1996-09-01

In September 1993, we initiated a regular program of photometric observations of Near-Earth objects. Since that time we have been allocated 5-7 nights per month at the 42'' Hall telescope at Anderson Mesa. There are three goals of our observing program for each asteroid: (1) to obtain an accurate rotation period and characterization of the lightcurve, (2) to obtain the surface color, and (3) to measure the photometric parameters, H and G. All of the lightcurve observations are made in Kron-Cousins R and we always obtain a V-R color. Limited ECAS colors are also obtained when the objects are bright enough. We have secured periods for 9 asteroids, 1864 Daedalus, 1866 Sisyphus, 3200 Phaethon, 4954 Eric, 5693 (1993 EA), 5836 (1993 MF), 6489 (1991 JX), 1993 QP, and 1993 WD. Some of these periods are a confimation of an earlier result but most are new. We obtained colors for all these objects as well as four additional asteroids, 5407 (1992 AX), 1993 UC, 1993 VW, and 1994 LW. We have additional (as yet unreduced) observations of 2062 Aten, 2212 Hephaistos, 3752 Camillo, 5143 Heracles, 5863 (1983 RB), 6053 (1993 BW3), 7025 (1993 QA), 7092 (1992 LC), 1989 VA, 1992 TC, 1994 RC, and 1995 YA3. The fastest rotation period we find is 2.402 hours for 1866 Sisyphus and the slowest is 93QP at ~ 24 hours. The colors for these objects range from V-R=0.34 for 3200 Phaethon to V-R=0.49 for 1866 Sisyphus and 4954 Eric. Most colors fall near V-R=0.43. These observations should help to provide a more complete understanding of the surface properties and rotational states of the Near-Earth asteroids. This work was supported by NASA Grant NAGW-1470.

Chronic cannabis users show altered neurophysiological functioning on Stroop task conflict resolution.

PubMed

Battisti, Robert A; Roodenrys, Steven; Johnstone, Stuart J; Pesa, Nicole; Hermens, Daniel F; Solowij, Nadia

2010-12-01

Chronic cannabis use has been related to deficits in cognition (particularly memory) and the normal functioning of brain structures sensitive to cannabinoids. There is increasing evidence that conflict monitoring and resolution processes (i.e. the ability to detect and respond to change) may be affected. This study examined the ability to inhibit an automatic reading response in order to activate a more difficult naming response (i.e. conflict resolution) in a variant of the discrete trial Stroop colour-naming task. Event-related brain potentials to neutral, congruent and incongruent trials were compared between 21 cannabis users (mean 16.4 years of near daily use) in the unintoxicated state and 19 non-using controls. Cannabis users showed increased errors on colour-incongruent trials (e.g. "RED" printed in blue ink) but no performance differences from controls on colour congruent (e.g. "RED" printed in red ink) or neutral trials (e.g. "*****" printed in green ink). Poorer incongruent trial performance was predicted by an earlier age of onset of regular cannabis use. Users showed altered expression of a late sustained potential related to conflict resolution, evident by opposite patterns of activity between trial types at midline and central sites, and altered relationships between neurophysiological and behavioural outcome measures not evident in the control group. These findings indicate that chronic use of cannabis may impair the brain's ability to respond optimally in the presence of events that require conflict resolution and hold implications for the ability to refrain from substance misuse and/or maintain substance abstention behaviours.

Analysis of Co-Located MODIS and CALIPSO Observations Near Clouds

NASA Technical Reports Server (NTRS)

Varnai, Tamas; Marshak, Alexander

2011-01-01

The purpose of this paper is to help researchers combine data from different satellites and thus gain new insights into two critical yet poorly understood aspects of anthropogenic climate change, aerosol-cloud interactions and aerosol radiative effects, For this, the paper explores whether cloud information from the Aqua satellite's MODIS instrument can help characterize systematic aerosol changes near clouds by refining earlier perceptions of these changes that were based on the CALIPSO satellite's CALIOP instrument. Similar to a radar but using visible and ncar-infrared light, CALIOP sends out laser pulses and provides aerosol and cloud information along a single line that tracks the satellite orbit by measuring the reflection of its pulses. In contrast, MODIS takes images of reflected sunlight and emitted infrared radiation at several wavelengths, and covers wide areas around the satellite track. This paper analyzes a year-long global dataset covering all ice-free oceans, and finds that MODIS can greatly help the interpretation of CALIOP observations, especially by detecting clouds that lie outside the line observed by CALlPSO. The paper also finds that complications such as differences in view direction or clouds drifting in the 72 seconds that elapse between MODIS and CALIOP observations have only a minor impact. The study also finds that MODIS data helps refine but does not qualitatively alter perceptions of the systematic aerosol changes that were detected in earlier studies using only CALIOP data. It then proposes a statistical approach to account for clouds lying outside the CALIOP track even when MODIS cannot as reliably detect low clouds, for example at night or over ice. Finally, the paper finds that, because of variations in cloud amount and type, the typical distance to clouds in maritime clear areas varies with season and location. The overall median distance to clouds in maritime clear areas around 4-5 km. The fact that half of all clear areas is

Study of weak substorms observed during December 8, 1990, geospace environment modeling campaign: Timing of different types of substorm onsets

NASA Astrophysics Data System (ADS)

Mishin, V. M.; Russell, C. T.; Saifudinova, T. I.; Bazarzhapov, A. D.

2000-10-01

We define an expansion onset (synonymous with the main breakup) to be one with sufficient signatures of open tail reconnection. Earlier onsets, which we term initial onsets, occur before the expansion onset, without the signatures of open tail reconnection but with other signs of a clear substorm onset. These two types of substorm onsets and their timing are discussed herein in a study of selected substorm-like events. During the 10-hour interval studied, five impulses of the Perreault-Akasofu index ɛ were observed with comparable peak values. However, the observed magnetospheric responses were very different in terms of equatorward motion and poleward expansion of the auroral oval. We conclude that the occurrence either of an initial onset or of a full onset (under similar boundary conditions) depends on the amount of stored free energy, proportional to the tail length, which is controlled by the input power. The earlier or initial onset marks a sudden change in the convection pattern in the nightside. This onset could mark the initiation of reconnection on closed field lines while the expansion onset could mark the initiation of reconnection on open field lines.

Change of tumor vascular reactivity during tumor growth and postchemotherapy observed by near-infrared spectroscopy

NASA Astrophysics Data System (ADS)

Lee, Songhyun; Jeong, Hyeryun; Seong, Myeongsu; Kim, Jae Gwan

2017-12-01

Breast cancer is one of the most common cancers in females. To monitor chemotherapeutic efficacy for breast cancer, medical imaging systems such as x-ray mammography, computed tomography, magnetic resonance imaging, and ultrasound imaging have been used. Currently, it can take up to 3 to 6 weeks to see the tumor response from chemotherapy by monitoring tumor volume changes. We used near-infrared spectroscopy (NIRS) to predict breast cancer treatment efficacy earlier than tumor volume changes by monitoring tumor vascular reactivity during inhalational gas interventions. The results show that the amplitude of oxy-hemoglobin changes (vascular reactivity) during hyperoxic gas inhalation is well correlated with tumor growth and responded one day earlier than tumor volume changes after chemotherapy. These results may imply that NIRS with respiratory challenges can be useful in early detection of tumor and in the prediction of tumor response to chemotherapy.

The characteristics of national health initiatives promoting earlier cancer diagnosis among adult populations: a systematic review protocol

PubMed Central

Calanzani, Natalia; Weller, David; Campbell, Christine

2017-01-01

Introduction The increasing burden of cancer morbidity and mortality has led to the development of national health initiatives to promote earlier cancer diagnosis and improve cancer survival. This protocol describes a systematic review aiming to identify the evidence about such initiatives among the adult population. We will describe their components, stakeholders and target populations, and summarise their outcomes. Methods and analysis We will search databases and websites for peer-reviewed publications and grey literature on national health initiatives in high-income countries as defined by the World Bank. Quantitative, qualitative and mixed-methods studies will be included and assessed for their methodological quality. Study selection, quality assessment and data extraction will be carried out independently by two reviewers. Narrative synthesis will be used to analyse the findings. Ethics and dissemination This systematic review analyses secondary data and ethical approval is not required. Review findings will be helpful to researchers, policy makers, governments and other key stakeholders developing similar initiatives and assessing cancer outcomes. The results will be submitted to a peer-reviewed journal in order to reach a diverse group of healthcare professionals, researchers and policy makers. This systematic review protocol is registered at PROSPERO (CRD42016047233). PMID:28698336

NuSTAR Observations of X-Ray Bursts from the Magnetar 1E 1048.1-5937

NASA Technical Reports Server (NTRS)

An, Hongjun; Kaspi, Victoria M.; Beloborodov, Andrei M.; Kouveliotou, Chryssa; Archibald, Robert T.; Boggs, Steven E.; Christensen, Finn E.; Craig, William W.; Gotthelf, Eric V.; Stern, Daniel;

Observations of Orion in all four 18 cm OH Thermal Absoprtion Lines

NASA Astrophysics Data System (ADS)

Moore, Amber M.; Momjian, Emmanuel; Troland, Thomas; Sarma, Anuj; Greisen, Eric

2018-01-01

We present results obtained with Karl G. Jansky Very Large Array (VLA) D-configuration observations of the 18 cm OH absorption lines in the Orion Veil; a sheet of material 2-4 pc in front of the Trapezium stars. The goals of these observations were to (a) measure the magnetic field through the Zeeman effect using the 18 cm OH mainlines at 1665 and 1667 MHz and compare the results with those obtained with the pre upgrade VLA, (b) observe all four 18 cm OH lines (the two mainlines and the two satellite lines at 1612 and 1720 MHz) to infer physical conditions in the absorbing regions. For the first goal, we found that the more recent measurements are comparable to the earlier published results. To achieve the second goal, we plan to use the Cloudy spectral synthesis code to model physical conditions based upon observations of all four 18 cm OH lines. We also anticipate using Cloudy to assess the viability of a model previously applied to the M17 PDR in which the magnetic field of the Veil is in hydrostatic equilibrium with radiation pressure of stellar uv from the Trapezium.

Observing Star and Planet Formation in the Submillimeter and Far Infrared

NASA Technical Reports Server (NTRS)

Yorke, Harold W.

2004-01-01

Stars from in the densest parts of cold interstellar clouds which-due to presence of obscuring dust-cannot be observed with optical telescopes. Recent rapid progress in understanding how stars and planets are formed has gone hand in hand with our ability to observe extremely young systems in the infrared and (submillimeter) spectral regimes. The detections and silhouetted imaging of disks around young objects in the visible and NIR have demonstrated the common occurrence of circumstellar disks and their associated jets and outflows in star forming regions. However, in order to obtain quantitative information pertaining to even earlier evolutionary phases, studies at longer wavelengths are necessary. From spectro-photometric imaging at all wavelengths we learn about the temperature and density structure of the young stellar environment. From narrow band imaging in the far infrared and submillimeter spectral regimes we can learn much about the velocity structure and the chemical makeup (pre-biotic material) of the planet-forming regions.

An operational monitoring and display system for phenological observations

NASA Astrophysics Data System (ADS)

Scheifinger, Helfried; Koch, Elisabeth

2013-04-01

Some national weather services operate a special web interface, where citizens can enter their phenological observations. Such a system opens the opportunity to immediately display the current state of the seasonal vegetation development. Here a few simple tools are introduced to evaluate and display near real time phenological observations with respect to the interannual variability and trends over the last decades. For many phenological phases continuous time series since 1946 are available in Austria, which is a time period sufficiently long to study the climate impact on phenology. Phenological observations can be entered in near real time via the ZAMG web - portal or be digitised after the season from the observer sheets with a considerable time lag. About 30% to 50% of the total phenological data stem from the near real time system, which can be used for near real time monitoring of the phenological season. The minimum number of observations, which must be available for inclusion in the procedure has arbitrarily been set to 12 in order to allow a reasonable height regression. The system installed at the ZAMG produces a nightly update of the statistical analysis and figures, which can then for instance be summarised for a news release. At the moment there is no spatial differentiation possible. All conclusions and figures are based on phenological entry dates over all Austrian observations, which have been standardised to an arbitrary station elevation of 200 m above sea level via height regression. The 2012 Austrian phenological season in relation to 1946 - 2011 The cold period from end of January to beginning of February 2012 in Austria has also left its marks on the phenological season. The early phases like beginning of flowering of snow drop, hazel or willow are to be found in the median position of rank 32 of 67 years since 1946. The remainder of the 2012 season generally shows rather early entry dates. On average the phenological entry dates range at

STEREO SECCHI Observations of Space Debris: Are They Associated with S/WAVES Dust Detections?

NASA Astrophysics Data System (ADS)

St. Cyr, O. C.; Howard, R. A.; Wang, D.; Thompson, W. T.; Harrison, R. A.; Kaiser, M. L.

2007-12-01

White-light coronagraphs are optimized to reject stray light in order to accomplish their primary science objective - - the observation of coronal mass ejections (CMEs) and the corona. Because they were designed to detect these faint signals while pointing at the Sun, many spacebased coronagraphs in the past (Skylab, SMM, SOHO) have detected "debris" apparently associated with the vehicle. These appear to be sunlit particles very near the front of the telescope aperture (~meters). In at least one case, these earlier debris sightings were interpreted as deteriorating insulation from the thermal blankets on the spacecraft (St. Cyr and Warner, 1991ASPC...17..126S); and for the earlier Sklyab observations, the sightings were believed to be associated with water droplets (Eddy, "A New Sun: The Solar Results from Skylab", NASA SP-402, p119, 1979.) The STEREO SECCHI suite of white-light coronagraphs represents the most recent instantations of these specialized instruments, and for the first time we are able to track CMEs from their initiation at the Sun out to 1 A.U. Since observations commenced, the SECCHI white-light telescopes have been sporadically detecting debris particles. Most of the detections are individual or small numbers of bright objects in the field which therefore do not affect the primary science goals of the mission. But on several occasions in the eight months' of observation there have been "swarms" of these bright objects which completely obscure the field of view of one or more instrument for a brief period of time. Here we report on the intriguing possibility that the SECCHI debris sightings represent particles of thermal insulation, ejected from the spacecraft by interplanetary dust impacts. Because of the large field of view and high duty cycle of the Heliospheric Imagers on STEREO, we may be able to demonstrate that some of these have also been detected by STEREO S/WAVES as sporadic plasma emissions.

3. BUILDING 8814, WEST SIDE AND SOUTH REAR, SHOWING BLAST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. BUILDING 8814, WEST SIDE AND SOUTH REAR, SHOWING BLAST DOOR. BUILDING 8826 IS IN BACKGROUND. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Observation Bunker 1-D-3, Test Area 1-125, northwest end of Altair Boulevard, Boron, Kern County, CA

New Observations of Molecular Nitrogen by the Imaging Ultraviolet Spectrograph on MAVEN

NASA Astrophysics Data System (ADS)

Stevens, Michael H.; Evans, J. S.; Schneider, Nicholas M.; Stewart, A. I. F.; Deighan, Justin; Jain, Sonal K.; Crismani, Matteo M. J.; Stiepen, Arnaud; Chaffin, Michael S.; McClintock, William E.; Holsclaw, Greg M.; Lefevre, Franck; Montmessin, Franck; Lo, Daniel Y.; Clarke, John T.; Bougher, Stephen W.; Jakosky, Bruce M.

2015-11-01

The Martian ultraviolet dayglow provides information on the basic state of the Martian upper atmosphere. The Imaging Ultraviolet Spectrograph (IUVS) on NASA’s Mars Atmosphere and Volatile Evolution (MAVEN) mission has observed Mars at mid and far-UV wavelengths since its arrival in September 2014. In this work, we describe a linear regression method used to extract components of UV spectra from IUVS limb observations and focus in particular on molecular nitrogen (N2) photoelectron excited emissions. We identify N2 Lyman-Birge-Hopfield (LBH) emissions for the first time at Mars and we also confirm the tentative identification of N2 Vegard-Kaplan (VK) emissions. We compare observed VK and LBH limb radiance profiles to model results between 90 and 210 km. Finally, we compare retrieved N2 density profiles to general circulation (GCM) model results. Contrary to earlier analyses using other satellite data that indicated N2 densities were a factor of three less than predictions, we find that N2 abundances exceed GCM results by about a factor of two at 130 km but are in agreement at 150 km.

Characterizing diurnal and seasonal cycles in monsoon systems from TRMM and CEOP observations

NASA Technical Reports Server (NTRS)

Lau, William K. M.

2006-01-01

The CEOP Inter-Monsoon Study (CIMS) is one of the two main science drivers of CEOP that aims to (a) provide better understanding of fundamental physical processes in monsoon regions around the world, and (b) demonstrate the synergy and utility of CEOP data in providing a pathway for model physics evaluation and improvement. As the data collection phase for EOP-3 and EOP-4 is being completed, two full annual cycles (2003-2004) of research-quality data sets from satellites, reference sites, and model output location time series (MOLTS) have been processed and made available for data analyses and model validation studies. This article presents preliminary results of a CIMS study aimed at the characterization and intercomparison of all major monsoon systems. The CEOP reference site data proved its value in such exercises by being a powerful tool to cross-validate the TRMM data, and to intercompare with multi-model results in ongoing work. We use 6 years (1998-2003) of pentad CEOP/TRMM data with 2deg x 2.5deg latitude-longitude grid, over the domain of interests to define the monsoon climatological diurnal and annual cycles for the East Asian Monsoon (EAM), the South Asian Monsoon (SAM), the West Africa Monsoon (WAM), the North America/Mexican Monsoon (NAM), the South American Summer Monsoon (SASM) and the Australian Monsoon (AUM). As noted, the TRMM data used in the study were cross-validated using CEOP reference site data, where applicable. Results show that the observed diurnal cycle of rain peaked around late afternoon over monsoon land, and early morning over the oceans. The diurnal cycles in models tend to peak 2-3 hours earlier than observed. The seasonal cycles of the EAM and SAM show the strongest continentality, i.e, strong control by continental processes away from the ITCZ. The WAM, and the AUM shows the less continentality, i.e, strong control by the oceanic ITCZ.

Characterizing Diurnal and Seasonal Cycles in Monsoon Systems from TRMM and CEOP Observations

NASA Technical Reports Server (NTRS)

Lau, William K. M.

2007-01-01

The CEOP Inter-Monsoon Study (CIMS) is one of the two main science drivers of CEOP that aims to (a) provide better understanding of fundamental physical processes in monsoon regions around the world, and (b) demonstrate the synergy and utility of CEOP data in providing a pathway for model physics evaluation and improvement. As the data collection phase for EOP-3 and EOP-4 is being completed, two full annual cycles (2003-2004) of research-quality data sets from satellites, reference sites, and model output location time series (MOLTS) have been processed and made available for data analyses and model validation studies. This article presents preliminary results of a CIMS study aimed at the characterization and intercomparison of all major monsoon systems. The CEOP reference site data proved its value in such exercises by being a powerful tool to cross-validate the TRMM data, and to intercompare with multi-model results in ongoing work. We use 6 years (1998-2003) of pentad CEOP/TRMM data with 2 deg x 2.5 deg. latitude-longitude grid, over the domain of interests to define the monsoon climatological diurnal and annual cycles for the East Asian Monsoon (EAM), the South Asian Monsoon (SAM), the West Africa Monsoon (WAM), the North America/Mexican Monsoon (NAM), the South American Summer Monsoon (SASM) and the Australian Monsoon (AUM). As noted, the TRMM data used in the study were cross-validated using CEOP reference site data, where applicable. Results show that the observed diurnal cycle of rain peaked around late afternoon over monsoon land, and early morning over the oceans. The diurnal cycles in models tend to peak 2-3 hours earlier than observed. The seasonal cycles of the EAM and SAM show the strongest continentality, i.e, strong control by continental processes away from the ITCZ. The WAM, and the AUM shows the less continentality, i.e, strong control by the oceanic ITCZ.

Contemporaneous observations of the radio galaxy NGC 1275 from radio to very high energy γ -rays

DOE PAGES

Aleksić, J.; Ansoldi, S.; Antonelli, L. A.; ...

2014-03-27

The radio galaxy NGC 1275, recently identified as a very high energy (VHE, >100 GeV) γ-ray emitter by MAGIC, is one of the few non-blazar active galactic nuclei detected in the VHE regime. The purpose of this work is to better understand the origin of the γ-ray emission and locate it within the galaxy. We studied contemporaneous multifrequency observations of NGC 1275 and modeled the overall spectral energy distribution. We analyzed unpublished MAGIC observations carried out between October 2009 and February 2010, and the previously published observations taken between August 2010 and February 2011. Here, we studied the multiband variabilitymore » and correlations by analyzing data of Fermi-LAT in the 100 MeV–100 GeV energy band, as well as Chandra (X-ray), KVA (optical), and MOJAVE (radio) data taken during the same period. Using customized Monte Carlo simulations corresponding to early MAGIC stereoscopic data, we detect NGC 1275 also in the earlier MAGIC campaign. The flux level and energy spectra are similar to the results of the second campaign. The monthly light curve above 100 GeV shows a hint of variability at the 3.6σ level. In the Fermi-LAT band, both flux and spectral shape variabilities are reported. Furthermore, the optical light curve is also variable and shows a clear correlation with the γ-ray flux above 100 MeV. In radio, three compact components are resolved in the innermost part of the jet. One of these components shows a similar trend as the Fermi-LAT and KVA light curves. The γ-ray spectra measured simultaneously with MAGIC and Fermi-LAT from 100 MeV to 650 GeV can be well fitted either by a log-parabola or by a power-law with a subexponential cutoff for the two observation campaigns. A single-zone synchrotron-self-Compton model, with an electron spectrum following a power-law with an exponential cutoff, can explain the broadband spectral energy distribution and the multifrequency behavior of the source. But, this model suggests an

Peculiar Outburst of A 0535+26 Observed with INTEGRAL, RXTE and Suzaku

NASA Technical Reports Server (NTRS)

Caballero, I.; Pottschmidt, K.; Barragan, L.; Ferrigno, C.; Kretschmar, P.; Suchy, S.; Wilms, J.; Santangelo, A.; Kreykenbohm, I.; Rothschild, R.;

10. INTERIOR VIEW SHOWING MOUNTINGS FROM TUNING DEVICE. VIEW SHOWS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. INTERIOR VIEW SHOWING MOUNTINGS FROM TUNING DEVICE. VIEW SHOWS COPPER SHEETING ON WALLS. - Chollas Heights Naval Radio Transmitting Facility, Helix House, 6410 Zero Road, San Diego, San Diego County, CA

Solar ALMA Observations: Constraining the Chromosphere above Sunspots

NASA Astrophysics Data System (ADS)

Loukitcheva, Maria A.; Iwai, Kazumasa; Solanki, Sami K.; White, Stephen M.; Shimojo, Masumi

2017-11-01

We present the first high-resolution Atacama Large Millimeter/Submillimeter Array (ALMA) observations of a sunspot at wavelengths of 1.3 and 3 mm, obtained during the solar ALMA Science Verification campaign in 2015, and compare them with the predictions of semi-empirical sunspot umbral/penumbral atmosphere models. For the first time, millimeter observations of sunspots have resolved umbral/penumbral brightness structure at the chromospheric heights, where the emission at these wavelengths is formed. We find that the sunspot umbra exhibits a radically different appearance at 1.3 and 3 mm, whereas the penumbral brightness structure is similar at the two wavelengths. The inner part of the umbra is ˜600 K brighter than the surrounding quiet Sun (QS) at 3 mm and is ˜700 K cooler than the QS at 1.3 mm, being the coolest part of sunspot at this wavelength. On average, the brightness of the penumbra at 3 mm is comparable to the QS brightness, while at 1.3 mm it is ˜1000 K brighter than the QS. Penumbral brightness increases toward the outer boundary in both ALMA bands. Among the tested umbral models, that of Severino et al. provides the best fit to the observational data, including both the ALMA data analyzed in this study and data from earlier works. No penumbral model among those considered here gives a satisfactory fit to the currently available measurements. ALMA observations at multiple millimeter wavelengths can be used for testing existing sunspot models, and serve as an important input to constrain new empirical models.

Van Allen Probe Observations of Chorus Wave Activity, Source and Seed electrons, and the Radiation Belt Response During ICME and CIR Storms

NASA Astrophysics Data System (ADS)

Bingham, S.; Mouikis, C.; Kistler, L. M.; Farrugia, C. J.; Paulson, K. W.; Huang, C. L.; Boyd, A. J.; Spence, H. E.; Kletzing, C.

2017-12-01

Whistler mode chorus waves are electromagnetic waves that have been shown to be a major contributor to enhancements in the outer radiation belt during geomagnetic storms. The temperature anisotropy of source electrons (10s of keV) provides the free energy for chorus waves, which can accelerate sub-relativistic seed electrons (100s of keV) to relativistic energies. This study uses Van Allen Probe observations to examine the excitation and plasma conditions associated with chorus wave observations, the development of the seed population, and the outer radiation belt response in the inner magnetosphere, for 25 ICME and 35 CIR storms. Plasma data from the Helium Oxygen Proton Electron (HOPE) instrument and magnetic field measurements from the Electric and Magnetic Field Instrument Suite and Integrated Science (EMFISIS) are used to identify chorus wave activity and to model a linear theory based proxy for chorus wave growth. A superposed epoch analysis shows a peak of chorus wave power on the dawnside during the storm main phase that spreads towards noon during the storm recovery phase. According to the linear theory results, this wave activity is driven by the enhanced convection driving plasma sheet electrons across the dayside. Both ICME and CIR storms show comparable levels of wave growth. Plasma data from the Magnetic Electron Ion Spectrometer (MagEIS) and the Relativistic Electron Proton Telescope (REPT) are used to observe the seed and relativistic electrons. A superposed epoch analysis of seed and relativistic electrons vs. L shows radiation belt enhancements with much greater frequency in the ICME storms, coinciding with a much stronger and earlier seed electron enhancement in the ICME storms.

DEMETER observations of bursty MF emissions and their relation to ground-level auroral MF burst

NASA Astrophysics Data System (ADS)

Broughton, M. C.; LaBelle, J.; Parrot, M.

2014-12-01

A survey of medium frequency (MF) electric field data from selected orbits of the Detection of Electro-Magnetic Emissions Transmitted from Earthquakes (DEMETER) spacecraft reveals 68 examples of a new type of bursty MF emissions occurring at high latitudes associated with auroral phenomena. These resemble auroral MF burst, a natural radio emission observed at ground level near local substorm onsets. Similar to MF burst, the bursty MF waves observed by DEMETER have broadband, impulsive frequency structure covering 1.5-3.0 MHz, amplitudes of 50-100 μV/m, an overall occurrence rate of ˜0.76% with higher occurrence during active times, and strong correlation with auroral hiss. The magnetic local time distribution of the MF waves observed by DEMETER shows peak occurrence rate near 18 MLT, somewhat earlier than the equivalent peak in the occurrence rate of ground level MF burst, though propagation effects and differences in the latitudes sampled by the two techniques may explain this discrepancy. Analysis of solar wind and SuperMAG data suggests that while the bursty MF waves observed by DEMETER are associated with enhanced auroral activity, their coincidence with substorm onset may not be as exact as that of ground level MF burst. One conjunction occurs in which MF burst is observed at Churchill, Manitoba, within 8 min of MF emissions detected by DEMETER on field lines approximately 1000 km southeast of Churchill. These observations may plausibly be associated with the same auroral event detected by ground level magnetometers at several Canadian observatories. Although it is uncertain, the balance of the evidence suggests that the bursty MF waves observed with DEMETER are the same phenomenon as the ground level MF burst. Hence, theories of MF burst generation in the ionosphere, such as beam-generated Langmuir waves excited over a range of altitudes or strong Langmuir turbulence generating a range of frequencies within a narrow altitude range, need to be revisited to

Towards earlier inclusion of Children in Tuberculosis (TB) drugs trials: Consensus statements from an Expert Panel

PubMed Central

Nachman, Sharon; Ahmed, Amina; Amanullah, Farhana; Becerra, Mercedes C; Botgros, Radu; Brigden, Grania; Browning, Renee; Gardiner, Elizabeth; Hafner, Richard; Hesseling, Anneke; How, Cleotilde; Jean-Philippe, Patrick; Lessem, Erica; Makhene, Mamodikoe; Mbelle, Nontombi; Marais, Ben; McIlleron, Helen; Mc Neeley, David F; Mendel, Carl; Murray, Stephen; Navarro, Eileen; Oramasionwu, Gloria E; Porcalla, Ariel R; Powell, Clydette; Powell, Mair; Rigaud, Mona; Rouzier, Vanessa; Samson, Pearl; Schaaf, H. Simon; Shah, Seema; Starke, Jeff; Swaminathan, Soumya; Wobudeya, Eric; Worrell, Carol

2015-01-01

Children represent a significant proportion of the global tuberculosis (TB) burden, and may be disproportionately more affected by its most severe clinical manifestations. Currently available treatments for pediatric drug-susceptible (DS) and drug-resistant (DR) TB, albeit generally effective, are hampered by high pill burden, long duration of treatment, coexistent toxicities, and an overall lack of suitable, child-friendly formulations. The complex and burdensome nature of administering the existing regimens to treat DS TB also contributes to the rise of DR TB strains. Despite the availability and use of these therapies for decades, a dearth of dosing evidence in children underscores the importance of sustained efforts for TB drug development to better meet the treatment needs of children with TB. Several new TB drugs and regimens with promising activity against both DS and DR TB strains have recently entered clinical development and are in various phases of clinical evaluation in adults or have received marketing authorization for adults. However, initiation of clinical trials to evaluate these drugs in children is often deferred, pending the availability of complete safety and efficacy data in adults or after drug approval. This document summarizes consensus statements from an international panel of childhood TB opinion leaders which support the initiation of evaluation of new TB drugs and regimens in children at earlier phases of the TB Drug development cycle. PMID:25957923

Show me the Monet.

PubMed

Duffin, Christian

2009-10-01

Experts in the United States believe that observation of art can help healthcare professionals diagnose illnesses and injuries in patients. This article reports on an art observation programme involving the University of Chicago Medical Center and the Art Institute of Chicago, Illinois, and reflects on whether such programmes can be replicated in the U.K.

ALMA Observations Show Major Mergers Among the Host Galaxies of Fast-growing, High-redshift​ Supermassive​ Black Holes

NASA Astrophysics Data System (ADS)

Trakhtenbrot, Benny; Lira, Paulina; Netzer, Hagai; Cicone, Claudia; Maiolino, Roberto; Shemmer, Ohad

2017-02-01

We present new ALMA band-7 data for a sample of six luminous quasars at z≃ 4.8, powered by fast-growing supermassive black holes (SMBHs) with rather uniform properties: the typical accretion rates and black hole masses are L/{L}{Edd}≃ 0.7 and {M}{BH}≃ {10}9 {M}⊙ . Our sample consists of three “FIR-bright” sources, which were individually detected in previous Herschel/SPIRE observations, with star formation rates of {SFR}> 1000 {M}⊙ {{yr}}-1, and three “FIR-faint” sources for which Herschel stacking analysis implies a typical SFR of ˜400 {M}⊙ {{yr}}-1. The dusty interstellar medium in the hosts of all six quasars is clearly detected in the ALMA data and resolved on scales of ˜2 kpc, in both continuum ({λ }{rest}˜ 150 μ {{m}}) and [{{C}} {{II}}] λ 157.74 μ {{m}} line emission. The continuum emission is in good agreement with the expectations from the Herschel data, confirming the intense SF activity in the quasar hosts. Importantly, we detect companion sub-millimeter galaxies (SMGs) for three sources—one FIR-bright and two FIR-faint, separated by ˜ 14{--}45 {kpc} and < 450 {km} {{{s}}}-1 from the quasar hosts. The [{{C}} {{II}}]-based dynamical mass estimates for the interacting SMGs are within a factor of ˜3 of the quasar hosts’ masses, while the continuum emission implies {{SFR}}{quasar}˜ (2{--}11)× {{SFR}}{SMG}. Our ALMA data therefore clearly support the idea that major mergers are important drivers for rapid early SMBH growth. However, the fact that not all high-SFR quasar hosts are accompanied by interacting SMGs and the gas kinematics as observed by ALMA suggest that other processes may be fueling these systems. Our analysis thus demonstrates the diversity of host galaxy properties and gas accretion mechanisms associated with early and rapid SMBH growth.

Space-based Observational Constraints for 1-D Plume Rise Models

NASA Technical Reports Server (NTRS)

Martin, Maria Val; Kahn, Ralph A.; Logan, Jennifer A.; Paguam, Ronan; Wooster, Martin; Ichoku, Charles

2012-01-01

We use a space-based plume height climatology derived from observations made by the Multi-angle Imaging SpectroRadiometer (MISR) instrument aboard the NASA Terra satellite to evaluate the ability of a plume-rise model currently embedded in several atmospheric chemical transport models (CTMs) to produce accurate smoke injection heights. We initialize the plume-rise model with assimilated meteorological fields from the NASA Goddard Earth Observing System and estimated fuel moisture content at the location and time of the MISR measurements. Fire properties that drive the plume-rise model are difficult to estimate and we test the model with four estimates for active fire area and four for total heat flux, obtained using empirical data and Moderate Resolution Imaging Spectroradiometer (MODIS) re radiative power (FRP) thermal anomalies available for each MISR plume. We show that the model is not able to reproduce the plume heights observed by MISR over the range of conditions studied (maximum r2 obtained in all configurations is 0.3). The model also fails to determine which plumes are in the free troposphere (according to MISR), key information needed for atmospheric models to simulate properly smoke dispersion. We conclude that embedding a plume-rise model using currently available re constraints in large-scale atmospheric studies remains a difficult proposition. However, we demonstrate the degree to which the fire dynamical heat flux (related to active fire area and sensible heat flux), and atmospheric stability structure influence plume rise, although other factors less well constrained (e.g., entrainment) may also be significant. Using atmospheric stability conditions, MODIS FRP, and MISR plume heights, we offer some constraints on the main physical factors that drive smoke plume rise. We find that smoke plumes reaching high altitudes are characterized by higher FRP and weaker atmospheric stability conditions than those at low altitude, which tend to remain confined

Ecological and toxicological responses in a multistressor scenario: Are monitoring programs showing the stressors or just showing stress? A case study in Brazil.

PubMed

López-Doval, Julio C; Meirelles, Sergio Tadeu; Cardoso-Silva, Sheila; Moschini-Carlos, Viviane; Pompêo, Marcelo

2016-01-01

The Metropolitan Region of São Paulo (MRSP) is located in the Brazilian State of São Paulo and reservoirs in this region are vital for water supply and energy production. Changes in economic, social, and demographic trends produced pollution of water bodies, decreasing water quality for human uses and affecting freshwater populations. The presence of emerging pollutants, classical priority substances, nutrient excess and the interaction with tropical-climate conditions require periodic reviews of water policies and monitoring programs in order to detect and manage these threats in a global change scenario. The objective of this work is to determine whether the monitoring program of the São Paulo's Environmental Agency, is sufficient to explain the toxicological and biological responses observed in organisms in reservoirs of the MRSP, and whether it can identify the possible agents causing these responses. For that, we used publicly available data on water quality compiled by this agency in their routine monitoring program. A general overview of these data and a chemometric approach to analyze the responses of biotic indexes and toxicological bioassays, as a function of the physical and chemical parameters monitored, were performed. Data compiled showed temporal and geographical information gaps on variables measured. Toxicological responses have been observed in the reservoirs of the MRSP, together with a high incidence of impairments of the zooplankton community. This demonstrates the presence of stressors that affect the viability of organisms and populations. The statistical approach showed that the data compiled by the environmental agency are insufficient to identify and explain the factors causing the observed ecotoxicological responses and impairments in the zooplankton community, and are therefore insufficient to identify clear cause-effect relationships. Stressors different from those analyzed could be responsible for the observed responses. Copyright �

Photoproduction of η mesons from the neutron: Cross sections and double polarization observable E

NASA Astrophysics Data System (ADS)

Witthauer, L.; Dieterle, M.; Afzal, F.; Anisovich, A. V.; Bantes, B.; Bayadilov, D.; Beck, R.; Bichow, M.; Brinkmann, K.-T.; Böse, S.; Challand, Th.; Crede, V.; Dutz, H.; Eberhardt, H.; Elsner, D.; Ewald, R.; Fornet-Ponse, K.; Friedrich, St.; Frommberger, F.; Funke, Ch.; Goertz, St.; Gottschall, M.; Gridnev, A.; Grüner, M.; Gutz, E.; Hammann, D.; Hammann, Ch.; Hannappel, J.; Hartmann, J.; Hillert, W.; Hoffmeister, Ph.; Honisch, Ch.; Jude, T.; Kaiser, D.; Kalinowsky, H.; Kalischewski, F.; Kammer, S.; Käser, A.; Keshelashvili, I.; Klassen, P.; Kleber, V.; Klein, F.; Koop, K.; Krusche, B.; Lang, M.; Lopatin, I.; Mahlberg, Ph.; Makonyi, K.; Metag, V.; Meyer, W.; Müller, J.; Müllers, J.; Nanova, M.; Nikonov, V.; Piontek, D.; Reicherz, G.; Rostomyan, T.; Sarantsev, A.; Schmidt, Ch.; Schmieden, H.; Seifen, T.; Sokhoyan, V.; Spieker, K.; Thiel, A.; Thoma, U.; Urban, M.; van Pee, H.; Walford, N. K.; Walther, D.; Wendel, Ch.; Werthmüller, D.; Wilson, A.; Winnebeck, A.

2017-03-01

Results from measurements of the photoproduction of η mesons from quasifree protons and neutrons are summarized. The experiments were performed with the CBELSA/TAPS detector at the electron accelerator ELSA in Bonn using the η→ 3π0→ 6γ decay. A liquid deuterium target was used for the measurement of total cross sections and angular distributions. The results confirm earlier measurements from Bonn and the MAMI facility in Mainz about the existence of a narrow structure in the excitation function of γ n→ nη. The current angular distributions show a forward-backward asymmetry, which was previously not seen, but was predicted by model calculations including an additional narrow P_{11} state. Furthermore, data obtained with a longitudinally polarized, deuterated butanol target and a circularly polarized photon beam were analyzed to determine the double polarization observable E. Both data sets together were also used to extract the helicity-dependent cross sections σ_{1/2} and σ_{3/2}. The narrow structure in the excitation function of γ n→ nη appears associated with the helicity-1/2 component of the reaction.

Sodium Atoms in the Lunar Exotail: Observed Velocity and Spatial Distributions

NASA Technical Reports Server (NTRS)

Line, Michael R.; Mierkiewicz, E. J.; Oliversen, R. J.; Wilson, J. K.; Haffner, L. M.; Roesler, F. L.

2011-01-01

The lunar sodium tail extends long distances due to radiation pressure on sodium atoms in the lunar exosphere. Our earlier observations determined the average radial velocity of sodium atoms moving down the lunar tail beyond Earth along the Sun-Moon-Earth line (i.e., the anti-lunar point) to be 12.4 km/s. Here we use the Wisconsin H-alpha Mapper to obtain the first kinematically resolved maps of the intensity and velocity distribution of this emission over a 15 x times 15 deg region on the sky near the anti-lunar point. We present both spatially and spectrally resolved observations obtained over four nights around new moon in October 2007. The spatial distribution of the sodium atoms is elongated along the ecliptic with the location of the peak intensity drifting 3 degrees east along the ecliptic per night. Preliminary modeling results suggest that the spatial and velocity distributions in the sodium exotail are sensitive to the near surface lunar sodium velocity distribution and that observations of this sort along with detailed modeling offer new opportunities to describe the time history of lunar surface sputtering over several days.

Eye movements reveal epistemic curiosity in human observers.

PubMed

Baranes, Adrien; Oudeyer, Pierre-Yves; Gottlieb, Jacqueline

2015-12-01

Saccadic (rapid) eye movements are primary means by which humans and non-human primates sample visual information. However, while saccadic decisions are intensively investigated in instrumental contexts where saccades guide subsequent actions, it is largely unknown how they may be influenced by curiosity - the intrinsic desire to learn. While saccades are sensitive to visual novelty and visual surprise, no study has examined their relation to epistemic curiosity - interest in symbolic, semantic information. To investigate this question, we tracked the eye movements of human observers while they read trivia questions and, after a brief delay, were visually given the answer. We show that higher curiosity was associated with earlier anticipatory orienting of gaze toward the answer location without changes in other metrics of saccades or fixations, and that these influences were distinct from those produced by variations in confidence and surprise. Across subjects, the enhancement of anticipatory gaze was correlated with measures of trait curiosity from personality questionnaires. Finally, a machine learning algorithm could predict curiosity in a cross-subject manner, relying primarily on statistical features of the gaze position before the answer onset and independently of covariations in confidence or surprise, suggesting potential practical applications for educational technologies, recommender systems and research in cognitive sciences. With this article, we provide full access to the annotated database allowing readers to reproduce the results. Epistemic curiosity produces specific effects on oculomotor anticipation that can be used to read out curiosity states. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

An Observational Study of the Relationship between Cloud, Aerosol and Meteorology in Broken Low-Level Cloud Conditions

NASA Technical Reports Server (NTRS)

Loeb, Norman G.; Schuster, Gregory L.

2008-01-01

Global satellite analyses showing strong correlations between aerosol optical depth and 3 cloud cover have stirred much debate recently. While it is tempting to interpret the results as evidence of aerosol enhancement of cloud cover, other factors such as the influence of meteorology on both the aerosol and cloud distributions can also play a role, as both aerosols and clouds depend upon local meteorology. This study uses satellite observations to examine aerosol-cloud relationships for broken low-level cloud regions off the coast of Africa. The analysis approach minimizes the influence of large-scale meteorology by restricting the spatial and temporal domains in which the aerosol and cloud properties are compared. While distributions of several meteorological variables within 5deg 5deg latitude-longitude regions are nearly identical under low and high aerosol optical depth, the corresponding distributions of single-layer low cloud properties and top-of-atmosphere radiative fluxes differ markedly, consistent with earlier studies showing increased cloud cover with aerosol optical depth. Furthermore, fine-mode fraction and Angstrom Exponent are also larger in conditions of higher aerosol optical depth, even though no evidence of systematic latitudinal or longitudinal gradients between the low and high aerosol optical depth populations are observed. When the analysis is repeated for all 5deg 5deg latitude-longitude regions over the global oceans (after removing cases in which significant meteorological differences are found between the low and high aerosol populations), results are qualitatively similar to those off the coast of Africa.

Real & Simulated IFU Observations of Low-Mass Early-Type Galaxies: Environmental Influence Probed for Cluster Galaxies

NASA Astrophysics Data System (ADS)

Sybilska, Agnieszka; Łokas, Ewa Luiza; Fouquet, Sylvain

2017-03-01

We combine high-quality IFU data with a new set of numerical simulations to study low-mass early type galaxies (dEs) in dense environments. Our earlier study of dEs in the Virgo cluster has produced the first large-scale maps of kinematic and stellar population properties of dEs in those environments (Ryś et al. 2013, 2014, 2015). A quantitative discrimination between various (trans)formation processes proposed for these objects is, however, a complex issue, requiring a priori assumptions about the progenitors of galaxies we observe and study today. To bridge this gap between observations and theoretical predictions, we use the expertise gained in the IFU data analysis to look ``through the eye of SAURON'' at our new suite of high-resolution N-body simulations of dEs in the Virgo cluster. Mimicking the observers perspective as closely as possible, we can also indicate the existing instrumental and viewer limitations regarding what we are/are not able to detect as observers.

Chandra Observations of Low Velocity Dispersion Groups

NASA Astrophysics Data System (ADS)

Helsdon, Stephen F.; Ponman, Trevor J.; Mulchaey, J. S.

2005-01-01

Deviations of galaxy groups from cluster scaling relations can be understood in terms of an excess of entropy in groups. The main effect of this excess is to reduce the density and thus the luminosity of the intragroup gas. Given this, groups should also show a steep relationship between X-ray luminosity and velocity dispersion. However, previous work suggests that this is not the case, with many measuring slopes flatter than the cluster relation. Examining the group LX-σ relation shows that much of the flattening is caused by a small subset of groups that show very high X-ray luminosities for their velocity dispersions (or vice versa). Detailed Chandra study of two such groups shows that earlier ROSAT results were subject to significant (~30%-40%) point-source contamination but confirm that a significant hot intergalactic medium is present in these groups, although these are two of the coolest systems in which intergalactic X-ray emission has been detected. Their X-ray properties are shown to be broadly consistent with those of other galaxy groups, although the gas entropy in NGC 1587 is unusually low, and its X-ray luminosity is correspondingly high for its temperature when compared with most groups. This leads us to suggest that the velocity dispersion in these systems has been reduced in some way, and we consider how this might have come about.

Solar X-Ray Irradiance Observations from the NOAA GOES Spacecraft: Accuracy vs Continuity

NASA Astrophysics Data System (ADS)

Viereck, R. A.; Machol, J. L.

2017-12-01

For 45 years, the solar X-Ray Sensors (XRS) on the GOES weather satellites have been making real-time measurements of the disk-integrated solar x-ray irradiance. These data have been remarkably consistent and contiguous and are the backbone of modern solar flare classification. When GOES 8 was launched in 1994, it observed 30% higher x-ray flux values compared to the earlier GOES. But no obvious cause of this offset was ever determined. For the sake of continuity, NOAA decided to adjust the GOES 8 data to match the old. We have been adjusting the XRS data on every GOES since (GOES 8-15). GOES 16 was launched in November of 2016 with a new XRS. This will be the first XRS that will have been fully calibrated with a primary calibration source so the values that it produces are presumed to be the most accurate yet. These new data show that our adjustment of the GOES 8 through 15 XRS data is not correct and that the true solar X-ray values are 30% higher than what has been reported for the last 45 years. In this presentation, we will show how the XRS sensors are characterized how the raw data are transformed into the science units that are presented to the public. We will present a plan on how to accurately present these new XRS values while maintaining continuity with the long record of XRS data.

Best in Show: Teaching Old Dogs to Use New Rubrics

ERIC Educational Resources Information Center

Hitt, Austin M.; Helms, Emory C.

2009-01-01

This paper discusses an instructional approach designed to help preservice teachers understand how assessments can be influenced by personal biases. In order to achieve this objective, we developed an analogy-based activity called "The Dog Show Analogy." After participating in the activity, we have observed that the participating preservice…

Earlier school start times are associated with higher rates of behavioral problems in elementary schools.

PubMed

Keller, Peggy S; Gilbert, Lauren R; Haak, Eric A; Bi, Shuang; Smith, Olivia A

2017-04-01

Early school start times may curtail children's sleep and inadvertently promote sleep restriction. The current study examines the potential implications for early school start times for behavioral problems in public elementary schools (student ages 5-12 years) in Kentucky. School start times were obtained from school Web sites or by calling school offices; behavioral and disciplinary problems, along with demographic information about schools, were obtained from the Kentucky Department of Education. Estimated associations controlled for teacher/student ratio, racial composition, school rank, enrollment, and Appalachian location. Associations between early school start time and greater behavioral problems (harassment, in-school removals, suspensions, and expulsions) were observed, although some of these associations were found only for schools serving the non-Appalachian region. Findings support the growing body of research showing that early school start times may contribute to student problems, and extend this research through a large-scale examination of elementary schools, behavioral outcomes, and potential moderators of risk. Copyright © 2017 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.

ASCA observations of the Large Magellanic Cloud supernova remnant sample: Typing supernovae from their remnants

NASA Technical Reports Server (NTRS)

Hughes, John P.; Hayashi, Ichizo; Helfand, David; Hwang, Una; Itoh, Masayuki; Kirshner, Robert; Koyama, Katsuji; Markert, Thomas; Tsunemi, Hiroshi; Woo, Jonathan

1995-01-01

We present our first results from a study of the supernova remnants (SNRs) in the Large Magellanic Cloud (LMC) using data from ASCA. The three remnants we have analyzed to date, 0509-67.5, 0519-69.0, and N103B, are among the smallest, and presumably also the youngest, in the Cloud. The X-ray spectra of these SNRs show strong K alpha emission lines of silicon, sulfur, argon, and calcium with no evidence for corresponding lines of oxygen, neon, or magnesium. The dominant feature in the spectra is a broad blend of emission lines around 1 keV which we attribute to L-shell emission lines of iron. Model calculations (Nomoto, Thielemann, & Yokoi 1984) show that the major products of nucleosynthesis in Type Ia supernovae (SNs) are the elements from silicon to iron, as observed here. The calculated nucleosynthetic yields from Type Ib and II SNs are shown to be qualitatively inconsistent with the data. We conclude that the SNs which produced these remnants were of Type Ia. This finding also confirms earlier suggestions that the class of Balmer-dominated remnants arise from Type Ia SN explosions. Based on these early results from the LMC SNR sample, we find that roughly one-half of the SNRs produced in the LMC within the last approximately 1500 yr came from Type Ia SNs.

Observation of tritium in gas/plasma loaded titanium samples

NASA Astrophysics Data System (ADS)

Srinivasan, M.; Shyam, A.; Kaushik, T. C.; Rout, R. K.; Kulkarni, L. V.; Krishnan, M. S.; Malhotra, S. K.; Nagvenkar, V. G.; Iyengar, P. K.

1991-05-01

The observation of significant neutron yield from gas loaded titanium samples at Frascati in April 1989 opened up an alternate pathway to the investigation of anomalous nuclear phenomena in deuterium/solid systems, complimenting the electrolytic approach. Since then at least six different groups have successfully measured burst neutron emission from deuterated titanium shavings following the Frascati methodology, the special feature of which was the use of liquid nitrogen to create repeated thermal cycles resulting in the production of non-equilibrium conditions in the deuterated samples. At Trombay several variations of the gas loading procedure have been investigated including induction heating of single machined titanium targets in a glass chamber as well as use of a plasma focus device for deuteriding its central titanium electrode. Stemming from earlier observations both at BARC and elsewhere that tritium yield is ≂108 times higher than neutron output in cold fusion experiments, we have channelised our efforts to the search for tritium rather than neutrons. The presence of tritium in a variety gas/plasma loaded titanium samples has been established successfully through a direct measurement of the radiations emitted as a result of tritium decay, in contradistinction to other groups who have looked for tritium in the extracted gases. In some samples we have thus observed tritium levels of over 10 MBq with a corresponding (t/d) ratio of ≳10-5.

The Autism Diagnostic Observation Schedule, Toddler Module: Standardized Severity Scores

PubMed Central

Esler, Amy N.; Bal, Vanessa Hus; Guthrie, Whitney; Wetherby, Amy; Weismer, Susan Ellis; Lord, Catherine

2016-01-01

Standardized calibrated severity scores (CSS) have been created for Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) Modules 1–4 as a metric of the relative severity of autism-specific behaviors. Total and domain CSS were created for the Toddler Module to facilitate comparison to other modules. Analyses included 388 children with ASD age 12 to 30 months and were replicated on 435 repeated assessments from 127 children with ASD. Compared to raw scores, associations between total and domain CSS and participant characteristics were reduced in the original sample. Verbal IQ effects on Social Affect-CSS were not reduced in the replication sample. Toddler Module CSS increases comparability of ADOS-2 scores across modules and allows studies of symptom trajectories to extend to earlier ages. PMID:25832801

28. MAP SHOWING LOCATION OF ARVFS FACILITY AS BUILT. SHOWS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

28. MAP SHOWING LOCATION OF ARVFS FACILITY AS BUILT. SHOWS LINCOLN BOULEVARD, BIG LOST RIVER, AND NAVAL REACTORS FACILITY. F.C. TORKELSON DRAWING NUMBER 842-ARVFS-101-2. DATED OCTOBER 12, 1965. INEL INDEX CODE NUMBER: 075 0101 851 151969. - Idaho National Engineering Laboratory, Advanced Reentry Vehicle Fusing System, Scoville, Butte County, ID

1. NORTHWEST FRONT AND SOUTHWEST SIDE, SHOWING LOCATION OF BUILDING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. NORTHWEST FRONT AND SOUTHWEST SIDE, SHOWING LOCATION OF BUILDING 0520 WEST OF FIRING CONTOL BLOCK HOUSE (BLDG. 0545), BETWEEN SLED TRACK AND CAMERA ACCESS ROAD. - Edwards Air Force Base, South Base Sled Track, Observation Block House, Station "O" area, east end of Sled Track, Lancaster, Los Angeles County, CA

Use of Discussion Board and PaperShow in Translation Class

ERIC Educational Resources Information Center

Takewa, Mika

2013-01-01

This report presents how the learning technologies Discussion Board and PaperShow are incorporated into postgraduate translation modules by means of observing their impact on students' learning. Initially and mainly for administrative reasons as well as being encouraged to make use of the university's virtual learning environment (VLE), I set up…

Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement.

PubMed

Cideciyan, Artur V; Jacobson, Samuel G; Beltran, William A; Sumaroka, Alexander; Swider, Malgorzata; Iwabe, Simone; Roman, Alejandro J; Olivares, Melani B; Schwartz, Sharon B; Komáromy, András M; Hauswirth, William W; Aguirre, Gustavo D

2013-02-05

Leber congenital amaurosis (LCA) associated with retinal pigment epithelium-specific protein 65 kDa (RPE65) mutations is a severe hereditary blindness resulting from both dysfunction and degeneration of photoreceptors. Clinical trials with gene augmentation therapy have shown partial reversal of the dysfunction, but the effects on the degeneration are not known. We evaluated the consequences of gene therapy on retinal degeneration in patients with RPE65-LCA and its canine model. In untreated RPE65-LCA patients, there was dysfunction and degeneration of photoreceptors, even at the earliest ages. Examined serially over years, the outer photoreceptor nuclear layer showed progressive thinning. Treated RPE65-LCA showed substantial visual improvement in the short term and no detectable decline from this new level over the long term. However, retinal degeneration continued to progress unabated. In RPE65-mutant dogs, the first one-quarter of their lifespan showed only dysfunction, and there was normal outer photoreceptor nuclear layer thickness retina-wide. Dogs treated during the earlier dysfunction-only stage showed improved visual function and dramatic protection of treated photoreceptors from degeneration when measured 5-11 y later. Dogs treated later during the combined dysfunction and degeneration stage also showed visual function improvement, but photoreceptor loss continued unabated, the same as in human RPE65-LCA. The results suggest that, in RPE65 disease treatment, protection from visual function deterioration cannot be assumed to imply protection from degeneration. The effects of gene augmentation therapy are complex and suggest a need for a combinatorial strategy in RPE65-LCA to not only improve function in the short term but also slow retinal degeneration in the long term.

The association between growth rate, body weight, backfat thickness and age at first observed oestrus in crossbred Landrace x Yorkshire gilts.

PubMed

Tummaruk, Padet; Tantasuparuk, Wichai; Techakumphu, Mongkol; Kunavongkrit, Annop

2009-01-01

The present study aims to investigate the association between growth rate (GR), body weight (BW), backfat thickness (BF) and age at first observed oestrus in crossbred Landrace x Yorkshire (LY) replacement gilts in the tropics. The study was carried out on five commercial swine herds in Thailand between 2004 and 2006. A total of 6946 LY gilts were included. The gilts entered the herd at about 163 days of age. The BW (kg) and BF (mm) of the gilts were measured when the gilts entered the gilt pools and again when the gilts were sent to the breeding house. The GR from birth to entry into the gilt pools (birth to 90 kg BW) (GRe), the GR from entry into to exit from the gilt pools (91-134 kg BW) (GRi) and the GR from birth until the gilts were sent to the breeding house (birth to 134 kg BW) (GRs) were calculated. The relationship between age at first observed oestrus and GRe, GRs, GRi, BW and BF were analyzed. Pearson's correlation and four general linear models (GLMs) were conducted. On average, the gilts showed first observed oestrus at 200+/-28 days of age. The means of age at first observed oestrus varied from 188 to 251 days (P<0.001) among the herds. The GRs of the gilts significantly correlated with the BW (r=0.55, P<0.001) of the gilts when they were sent to the breeding house and the age at first observed oestrus (r=-0.40, P<0.001). Gilts with a high GRe and GRs were younger at first observed oestrus compared to gilts with a low GRe and GRs. On average, the gilts with GRs of over 604 g/day showed first observed oestrus before 5 months of age. GRi was not correlated with the age at first observed oestrus (P>0.05). Neither the BF of the gilts at entry nor the BF that the gilts gained within the gilt pools significantly correlated with age at first observed oestrus (P=0.29 and P=0.69, respectively). But the gilts with a higher BF at entry tended to have a higher BW when they were sent to the breeding house (r=0.44, P<0.001). The present study indicates that

An earlier explosion date for the Crab Nebula supernova

NASA Astrophysics Data System (ADS)

Abt, Helmut A.; Fountain, John W.

2018-04-01

The Chinese first reported the Crab Nebula supernova on 1054 July 5. Ecclesiastical documents from the near east reported it in April and May of 1054. More than 33 petroglyphs made by Native Americans in the US and Mexico are consistent with sightings both before and after conjunction with the Sun on 1054 May 27. We found a petroglyph showing the new star close to Venus and the Moon, which occurred on 1054 April 12 and April 13, respectively. Collins et al., using the four historical dates, derived a light curve that is like that of a Type Ia supernova. The only remaining problem with this identification is that this supernova was near maximum light for 85 d, which is unlike the behavior of any known supernova.

Initial survey of the wave distribution functions for plasmaspheric hiss observed by ISEE 1

NASA Technical Reports Server (NTRS)

Storey, L. R. O.; Lefeuvre, F.; Parrot, M.; Cairo, L.; Anderson, R. R.

1991-01-01

The generation mechanism of hiss observed by ISEE 1 satellite in the earth magnetosphere is investigated by analyzing the ELF/VLF wave data obtained from four passes of ISEE 1, all of which occurring during magnetically quiet periods. The results of these measurements, together with those published earlier, indicate that the generation mechanisms proposed by Kennel alnd Petschek (1966), by Thorne et al. (1979), and by Solomon et al. (1988, 1989) are all physically possible and can come into action whenever the necessary conditions exist. However, plasmaspheric hiss was observed by ISEE even when the conditions for any of these mechanisms existed; under these conditions, hiss appears to be generated near the equatorial plane over a wide range of L values, with the wave normals at large angles to the field. The generation mechanism that applies in such cases is still unknown.

[Dynamic observation of clinical course in patients with subacute 1, 2-dichloroethane poisoning].

PubMed

Liu, Weiwei; Chen, Yuquan; Pan, Jing; Yang, Zhiqian; Liu, Yimin

2015-03-01

To observe the clinical characteristics and regular patterns of subacute 1, 2-dichloroethane poisoning patients for providing evidences to it's diagnosis, treatment and prognosis. 51 cases of subacute 1, 2-dichloroethane poisoning analyzed. They were divided into 3 groups according to their main clinical manifestation: group A mainly with intracranial hypertension (n = 25), group B with limbs tremor (n = 18), group C with mental and behavior disorder (n = 8). All cases' clinical symptoms, cranial computer tomography, cerebrospinal pressure (Group A) were observed, the durations of the onset, deterioration, improvement, recovery and whole course of the disease were compared between groups and in each group. In all of 51 cases, only the differences between the deterioration duration of cranial CT and symptom was significantly (t = 2.555, P<0.05), which indicate the deterioration of symptom was earlier than radiological change. The symptom deterioration of group C was the fastest than group A and group B (P<0.00). As to the change of symptom duration, group B's improvement, recovery and whole course was the longest comparing with group A and group C (P<0.05). As to the change of cranial CT duration, group B's recovery duration was the shortest and group A's recovery duration was the longest (P<0.01); group B's whole course was also the shortest and group A's whole course was the longest (P<0.05). The clinical course of symptoms, cranial computer tomography, cerebrospinal pressure (Group A) was compared in each group, in group A, the duration of improvement and whole course of the cranial CT and cerebrospinal pressure change was longer than that of the symptom change (P<0.01), this indicated that group A has longer asymptomatic intracranial hypertension and their cranial radiography recover slowly. In group B, their symptoms (3.94 ± 4.31 days) deteriorated is earlier than cranial CT changes (P<0.05), the recovery (92.39 ± 55.04 days) and whole course of symptom was

Observing storm surges from satellite altimetry

NASA Astrophysics Data System (ADS)

Han, Guoqi

2016-07-01

Storm surges can cause catastrophic damage to properties and loss of life in coastal communities. Thus it is important to enhance our capabilities of observing and forecasting storm surges for mitigating damage and loss. In this presentation we show examples of observing storm surges around the world using nadir satellite altimetry, during Hurricane Sandy, Igor, and Isaac, as well as other cyclone events. The satellite observations are evaluated against tide-gauge observations and discussed for dynamic mechanisms. We also show the potential of a new wide-swath altimetry mission, the Surface Water and Ocean Topography (SWOT), for observing storm surges.

TRMM-TMI Satellite Observed Soil Moisture and Vegetation Density (1998-2005) Show Strong Connection with El Nino in Eastern Australia

NASA Technical Reports Server (NTRS)

Liu, Yi; van Dijk, Albert I.J.M.; Owe, Manfred

2007-01-01

Spatiotemporal patterns in soil moisture and vegetation water content across mainland Australia were investigated from 1998 through 2005, using TRMMITMI passive microwave observations. The Empirical Orthogonal Function technique was used to extract dominant spatial and temporal patterns in retrieved estimates of moisture content for the top 1-cm of soil (theta) and vegetation moisture content (via optical depth tau). The dominant temporal theta and tau patterns were strongly correlated to El Nino/Southern Oscillation (ENSO) in spring (3 = 0.90), and to a progressively lesser extent autumn, summer and winter. The Indian Ocean Dipole (IOD) index also explained part of the variation in spring 8 and z. Cluster analysis suggested that the regions most affected by ENS0 are mainly located in eastern Australia. The results suggest that the drought conditions experienced in eastern Australia since 2000 an clearly expressed in these satellite observations have a strong connection with ENSO patterns.

Documentation for the machine-readable version of A Finding List of Stars of Spectral Type F2 and Earlier in a North Galactic Pole Region

NASA Technical Reports Server (NTRS)

Warren, W. H., Jr.

1982-01-01

The machine-readable data set is the result of an objective-prism survey made with an 80 cm/120 cm Schmidt telescope. The F2 and earlier stars were isolated from later type objects by using the MK classification criteria. The catalog contains 601 stars and includes cross identifications to the BD and HD catalogs, coordinates, photographic magnitudes and spectral types. A separate file contains the remarks from the original data tables merged with those following the data. The machine-readable files are described.

How supernovae became the basis of observational cosmology

NASA Astrophysics Data System (ADS)

Pruzhinskaya, Maria Victorovna; Lisakov, Sergey Mikhailovich

2016-12-01

This paper is dedicated to the discovery of one of the most important relationships in supernova cosmology - the relation between the peak luminosity of Type Ia supernovae and their luminosity decline rate after maximum light. The history of this relationship is quite long and interesting. The relationship was independently discovered by the American statistician and astronomer Bert Woodard Rust and the Soviet astronomer Yury Pavlovich Pskovskii in the 1970s. Using a limited sample of Type I supernovae they were able to show that the brighter the supernova is, the slower its luminosity declines after maximum. Only with the appearance of CCD cameras could Mark Phillips re-inspect this relationship on a new level of accuracy using a better sample of supernovae. His investigations confirmed the idea proposed earlier by Rust and Pskovskii.

From pattern to process: The strategy of the Earth Observing System: Volume 2: EOS Science Steering Committee report

NASA Technical Reports Server (NTRS)

1987-01-01

The Earth Observing System (EOS) represents a new approach to the study of the Earth. It consists of remotely sensed and correlative in situ observations designed to address important, interrelated global-scale processes. There is an urgent need to study the Earth as a complete, integrated system in order to understand and predict changes caused by human activities and natural processes. The EOS approach is based on an information system concept and designed to provide a long-term study of the Earth using a variety of measurement methods from both operational and research satellite payloads and continuing ground-based Earth science studies. The EOS concept builds on the foundation of the earlier, single-discipline space missions designed for relatively short observation periods. Continued progress in our understanding of the Earth as a system will come from EOS observations spanning several decades using a variety of contemporaneous measurements.

Computing 3-D wavefields in mantle circulations models to test hypotheses on the origin of lower mantle heterogeneity under Africa directly against seismic observations

NASA Astrophysics Data System (ADS)

Schuberth, Bernhard; Zaroli, Christophe; Nolet, Guust

2015-04-01

Of particular interest for the tectonic evolution of the Atlantic region is the influence of lower mantle structure under Africa on flow in the upper mantle beneath the ocean basin. Along with its Pacific counterpart, the large African anomaly in the lowermost mantle with strongly reduced seismic velocities has received considerable attention in seismological and geodynamic studies. Several seismological observations are typically taken as an indication that these two anomalies are being caused by large-scale compositional variations and that they are piles of material with higher density than normal mantle rock. This would imply negative buoyancy in the lowermost mantle under Africa, which has important implications for the flow at shallower depth and inferences on the processes that led to the formation of the Atlantic Ocean basin. However, a large number of recent studies argue for a strong thermal gradient across the core-mantle boundary that might provide an alternative explanation for the lower mantle anomaly through the resulting large lateral temperature variations. Recently, we developed a new joint forward modeling approach to test such geodynamic hypotheses directly against the seismic observations: Seismic heterogeneity is predicted by converting the temperature field of a high-resolution 3-D mantle circulation model into seismic velocities using thermodynamic models of mantle mineralogy. 3-D global wave propagation in the synthetic elastic structures is then simulated using a spectral element method. Being based on forward modelling only, this approach allows us to generate synthetic wavefields and seismograms independently of seismic observations. The statistics of observed long-period body wave traveltime variations show a markedly different behaviour for P- and S-waves: the standard deviation of P-wave delay times stays almost constant with ray turning depth, while that of the S-wave delay times increases strongly throughout the mantle. In an

Earth Observations

NASA Image and Video Library

2010-07-23

ISS024-E-009404 (23 July 2010) --- This photo taken from the International Space Station on July 23, 2010, shows the Gulf of Mexico oil spill as part of ongoing observations of the region. When this image was taken, three months after the explosion on the Deepwater Horizon oil rig, the leak had been plugged for eight days. Water surfaces appear bright and land surfaces appear dark in the image. The stark contrast is due to sun glint, in which the sun is reflected brilliantly off all water surfaces back towards the astronaut observer on board the station. The sun glint reveals various features in the Gulf of Mexico, especially sheens of oil as packets of long bright streaks seen on the left side of the image. Sediments carried by the Mississippi River have a light-yellow coloration in this image, with distinct margins between plumes that likely mark tidal pulses of river water into the Gulf of Mexico. A boat wake cuts across one of the oil packets at image lower left. Daily National Oceanic and Atmospheric Administration (NOAA) maps of oil distribution show predicted heavier and lighter oil movement near the Gulf coastline. The maps show that on the day this image was taken, the north edge of the ?oiled? zone was expected to bank up against the delta. The observed spread of the surface oil in the approximately 100 days since the explosion highlights the connectivity between the deepwater areas and coastlines of the Gulf of Mexico.

Earlier surgery improves outcomes from painful chronic pancreatitis

PubMed Central

Ke, Nengwen; Jia, Dan; Huang, Wei; Nunes, Quentin M.; Windsor, John A.; Liu, Xubao; Sutton, Robert

2018-01-01

Abstract The timing of surgery for painful chronic pancreatitis (CP) may affect outcomes. Clinical course, Izbicki pain scores, and pancreatic function were retrospectively compared and analyzed between patients undergoing either early or late surgery (< 3 or ≥ 3 years from diagnosis) for painful CP in a single center from 2007 to 2012. The early surgery group (n = 98) more frequently than the late group (n = 199) had abdominal pain with jaundice (22.4% vs 9.5%, P = .002) and pancreatic mass +/− ductal dilatation (47% vs 27%, P < .001), but less frequently abdominal pain alone (73.5% vs 85.9%, P = .009), ductal dilatation alone (31% vs 71%, P < .001), parenchymal calcification (91.8% vs 100%, P < .001) or exocrine insufficiency (60% vs 72%, P = .034); there were no other significant differences. The early group had longer hospital stay (14.4 vs 12.2 days, P = .009), but no difference in complications. Significantly greater pain relief followed early surgery (complete 69% vs 47%, partial 22% vs 37%, none 8% vs 16%, P = .01) with lower rates of exocrine (60% vs 80%, P = .005) and endocrine insufficiency (36% vs 53%, P = .033). Our data indicate that early surgery results in higher rates of pain relief and pancreatic sufficiency than late surgery for chronic pancreatitis patients. Frey and Berne procedures showed better results than other surgical procedures. PMID:29742705

Earlier surgery improves outcomes from painful chronic pancreatitis.

PubMed

Ke, Nengwen; Jia, Dan; Huang, Wei; Nunes, Quentin M; Windsor, John A; Liu, Xubao; Sutton, Robert

2018-05-01

The timing of surgery for painful chronic pancreatitis (CP) may affect outcomes.Clinical course, Izbicki pain scores, and pancreatic function were retrospectively compared and analyzed between patients undergoing either early or late surgery (< 3 or ≥ 3 years from diagnosis) for painful CP in a single center from 2007 to 2012.The early surgery group (n = 98) more frequently than the late group (n = 199) had abdominal pain with jaundice (22.4% vs 9.5%, P = .002) and pancreatic mass +/- ductal dilatation (47% vs 27%, P < .001), but less frequently abdominal pain alone (73.5% vs 85.9%, P = .009), ductal dilatation alone (31% vs 71%, P < .001), parenchymal calcification (91.8% vs 100%, P < .001) or exocrine insufficiency (60% vs 72%, P = .034); there were no other significant differences. The early group had longer hospital stay (14.4 vs 12.2 days, P = .009), but no difference in complications. Significantly greater pain relief followed early surgery (complete 69% vs 47%, partial 22% vs 37%, none 8% vs 16%, P = .01) with lower rates of exocrine (60% vs 80%, P = .005) and endocrine insufficiency (36% vs 53%, P = .033).Our data indicate that early surgery results in higher rates of pain relief and pancreatic sufficiency than late surgery for chronic pancreatitis patients. Frey and Berne procedures showed better results than other surgical procedures.

High-latitude electron density observations from the IMAGE radio plasma imager

NASA Astrophysics Data System (ADS)

Henize, Vance Karl

2003-11-01

Before the IMAGE mission, electron densities in the high latitude, high altitude region of the magnetosphere were measured exclusively by in situ means. The Radio Plasma Imager instrument onboard IMAGE is capable of remotely observing electron densities between 0.01 and 100,000 e-/cm-3 from distances of several Earth radii or more. This allows a global view of the high latitude region that has a far greater accuracy than was previously possible. Soundings of the terrestrial magnetic cusp provide the first remote observations of the dynamics and poleward density profile of this feature continuously over a 60- minute interval. During steady quiet-time solar wind and interplanetary magnetic field conditions, the cusp is shown to be stable in both position and density structure with only slight variations in both. Peak electron densities within the cusp during this time are found to be somewhat higher than predicted. New procedures for deriving electron densities from radio sounding measurements are developed. The addition of curve fitting algorithms significantly increases the amount of useable data. Incorporating forward modeling techniques greatly reduces the computational time over traditional inversion methods. These methods are described in detail. A large number high latitude observations of ducted right-hand extraordinary mode waves made over the course of one year of the IMAGE mission are used to create a three dimensional model of the electron density profile of the terrestrial polar cap region. The dependence of electron density in the polar cap on average geocentric distance (d) is found to vary as d-6.6. This is a significantly steeper gradient than cited in earlier works such as Persoon et al., although the introduction of an asymptotic term provides for basic agreement in the limited region of their joint validity. Latitudinal and longitudinal variations are found to be insignificant. Both the mean profile power law index of the electron density profile

The observing campaign on the deep-space debris WT1190F as a test case for short-warning NEO impacts

NASA Astrophysics Data System (ADS)

Micheli, Marco; Buzzoni, Alberto; Koschny, Detlef; Drolshagen, Gerhard; Perozzi, Ettore; Hainaut, Olivier; Lemmens, Stijn; Altavilla, Giuseppe; Foppiani, Italo; Nomen, Jaime; Sánchez-Ortiz, Noelia; Marinello, Wladimiro; Pizzetti, Gianpaolo; Soffiantini, Andrea; Fan, Siwei; Frueh, Carolin

2018-04-01

On 2015 November 13, the small artificial object designated WT1190F entered the Earth atmosphere above the Indian Ocean offshore Sri Lanka after being discovered as a possible new asteroid only a few weeks earlier. At ESA's SSA-NEO Coordination Centre we took advantage of this opportunity to organize a ground-based observational campaign, using WT1190F as a test case for a possible similar future event involving a natural asteroidal body.

Helicity-dependent cross sections and double-polarization observable E in η photoproduction from quasifree protons and neutrons

NASA Astrophysics Data System (ADS)

Witthauer, L.; Dieterle, M.; Abt, S.; Achenbach, P.; Afzal, F.; Ahmed, Z.; Akondi, C. S.; Annand, J. R. M.; Arends, H. J.; Bashkanov, M.; Beck, R.; Biroth, M.; Borisov, N. S.; Braghieri, A.; Briscoe, W. J.; Cividini, F.; Costanza, S.; Collicott, C.; Denig, A.; Downie, E. J.; Drexler, P.; Ferretti-Bondy, M. I.; Gardner, S.; Garni, S.; Glazier, D. I.; Glowa, D.; Gradl, W.; Günther, M.; Gurevich, G. M.; Hamilton, D.; Hornidge, D.; Huber, G. M.; Käser, A.; Kashevarov, V. L.; Kay, S.; Keshelashvili, I.; Kondratiev, R.; Korolija, M.; Krusche, B.; Lazarev, A. B.; Linturi, J. M.; Lisin, V.; Livingston, K.; Lutterer, S.; MacGregor, I. J. D.; Mancell, J.; Manley, D. M.; Martel, P. P.; Metag, V.; Meyer, W.; Miskimen, R.; Mornacchi, E.; Mushkarenkov, A.; Neganov, A. B.; Neiser, A.; Oberle, M.; Ostrick, M.; Otte, P. B.; Paudyal, D.; Pedroni, P.; Polonski, A.; Prakhov, S. N.; Rajabi, A.; Reicherz, G.; Ron, G.; Rostomyan, T.; Sarty, A.; Sfienti, C.; Sikora, M. H.; Sokhoyan, V.; Spieker, K.; Steffen, O.; Strakovsky, I. I.; Strub, Th.; Supek, I.; Thiel, A.; Thiel, M.; Thomas, A.; Unverzagt, M.; Usov, Yu. A.; Wagner, S.; Walford, N. K.; Watts, D. P.; Werthmüller, D.; Wettig, J.; Wolfes, M.; Zana, L.; A2 Collaboration at MAMI

2017-05-01

Precise helicity-dependent cross sections and the double-polarization observable E were measured for η photoproduction from quasifree protons and neutrons bound in the deuteron. The η →2 γ and η →3 π0→6 γ decay modes were used to optimize the statistical quality of the data and to estimate systematic uncertainties. The measurement used the A2 detector setup at the tagged photon beam of the electron accelerator MAMI in Mainz. A longitudinally polarized deuterated butanol target was used in combination with a circularly polarized photon beam from bremsstrahlung of a longitudinally polarized electron beam. The reaction products were detected with the electromagnetic calorimeters Crystal Ball and TAPS, which covered 98% of the full solid angle. The results show that the narrow structure observed earlier in the unpolarized excitation function of η photoproduction off the neutron appears only in reactions with antiparallel photon and nucleon spin (σ1 /2). It is absent for reactions with parallel spin orientation (σ3 /2) and thus very probably related to partial waves with total spin 1/2. The behavior of the angular distributions of the helicity-dependent cross sections was analyzed by fitting them withLegendre polynomials. The results are in good agreement with a model from the Bonn-Gatchina group, which uses an interference of P11 and S11 partial waves to explain the narrow structure.

Absorption Properties of Supercooled Liquid Water between 31 and 225 GHz: Evaluation of Absorption Models Using Ground-Based Observations

DOE PAGES

Kneifel, Stefan; Redl, Stephanie; Orlandi, Emiliano; ...

2014-04-10

Microwave radiometers (MWR) are commonly used to quantify the amount of supercooled liquid water (SLW) in clouds; however, the accuracy of the SLW retrievals is limited by the poor knowledge of the SLW dielectric properties at microwave frequencies. Six liquid water permittivity models were compared with ground-based MWR observations between 31 and 225 GHz from sites in Greenland, the German Alps, and a low-mountain site; average cloud temperatures of observed thin cloud layers range from 0° to –33°C. A recently published method to derive ratios of liquid water opacity from different frequencies was employed in this analysis. These ratios aremore » independent of liquid water path and equal to the ratio of αL at those frequencies that can be directly compared with the permittivity model predictions. The observed opacity ratios from all sites show highly consistent results that are generally within the range of model predictions; however, none of the models are able to approximate the observations over the entire frequency and temperature range. Findings in earlier published studies were used to select one specific model as a reference model for αL at 90 GHz; together with the observed opacity ratios, the temperature dependence of αL at 31.4, 52.28, 150, and 225 GHz was derived. The results reveal that two models fit the opacity ratio data better than the other four models, with one of the two models fitting the data better for frequencies below 90 GHz and the other for higher frequencies. Furthermore, these findings are relevant for SLW retrievals and radiative transfer in the 31–225-GHz frequency region.« less

Oral Exposure to Paraquat Triggers Earlier Expression of Phosphorylated α-Synuclein in the Enteric Nervous System of A53T Mutant Human α-Synuclein Transgenic Mice

PubMed Central

Naudet, Nicolas; Antier, Emilie; Gaillard, Damien; Morignat, Eric; Lakhdar, Latifa; Baron, Thierry; Bencsik, Anna

2017-01-01

Abstract The misfolded α-synuclein protein, phosphorylated at serine 129 (pSer129 α-syn), is the hallmark of Parkinson disease (PD). Detected also in the enteric nervous system (ENS), it supports the recent theory that PD could start in the gut, rather than the brain. In a previous study, using a transgenic mouse model of human synucleinopathies expressing the A53T mutant α-synuclein (TgM83), in which a neurodegenerative process associated with α-synuclein occurs spontaneously in the brain, we have shown earlier onset of pSer129 α-syn in the ENS. Here, we used this model to study the impact of paraquat (PQ) a neurotoxic herbicide incriminated in PD in agricultural workers) on the enteric pSer129 α-syn expression in young mice. Orally delivered in the drinking water at 10 mg/kg/day for 6–8 weeks, the impact of PQ was measured in a time-dependent manner on weight, locomotor abilities, pSer129 α-syn, and glial fibrillary acidic protein (GFAP) expression levels in the ENS. Remarkably, pSer129 α-syn was detected in ENS earlier under PQ oral exposure and enteric GFAP expression was also increased. These findings bring additional support to the theory that neurotoxic agents such as PQ initiate idiopathic PD after oral delivery. PMID:29040593

Oral Exposure to Paraquat Triggers Earlier Expression of Phosphorylated α-Synuclein in the Enteric Nervous System of A53T Mutant Human α-Synuclein Transgenic Mice.

PubMed

Naudet, Nicolas; Antier, Emilie; Gaillard, Damien; Morignat, Eric; Lakhdar, Latifa; Baron, Thierry; Bencsik, Anna

2017-12-01

The misfolded α-synuclein protein, phosphorylated at serine 129 (pSer129 α-syn), is the hallmark of Parkinson disease (PD). Detected also in the enteric nervous system (ENS), it supports the recent theory that PD could start in the gut, rather than the brain. In a previous study, using a transgenic mouse model of human synucleinopathies expressing the A53T mutant α-synuclein (TgM83), in which a neurodegenerative process associated with α-synuclein occurs spontaneously in the brain, we have shown earlier onset of pSer129 α-syn in the ENS. Here, we used this model to study the impact of paraquat (PQ) a neurotoxic herbicide incriminated in PD in agricultural workers) on the enteric pSer129 α-syn expression in young mice. Orally delivered in the drinking water at 10 mg/kg/day for 6-8 weeks, the impact of PQ was measured in a time-dependent manner on weight, locomotor abilities, pSer129 α-syn, and glial fibrillary acidic protein (GFAP) expression levels in the ENS. Remarkably, pSer129 α-syn was detected in ENS earlier under PQ oral exposure and enteric GFAP expression was also increased. These findings bring additional support to the theory that neurotoxic agents such as PQ initiate idiopathic PD after oral delivery. © 2017 American Association of Neuropathologists, Inc.

Jellyfish: Observational Properties of Extreme Ram-Pressure Stripping Events in Massive Galaxy Clusters

NASA Astrophysics Data System (ADS)

Conor, McPartland; Ebeling, Harald; Roediger, Elke

2015-08-01

We investigate the physical origin and observational signatures of extreme ram-pressure stripping (RPS) in 63 massive galaxy clusters at z=0.3-0.7, based on data in the F606W passband obtained with the Advanced Camera for Surveys aboard the Hubble Space Telescope. Using a training set of a dozen ``jellyfish" galaxies identified earlier in the same imaging data, we define quantitative morphological criteria to select candidate galaxies which are similar to known cases of RPS. Considering a sample of 16 ``jellyfish" galaxies (10 of which we present for the first time), we visually derive estimates of the projected direction of motion based on dynamical features such as apparent compression shocks and debris trails. Our findings suggest that the observed events occur primarily at large distances from the cluster core and involve infall trajectories featuring high impact parameters. Simple models of cluster growth show that such trajectories are consistent with two scenarios: 1) galaxy infall along filaments; and 2) infall at high velocities (≥1000 km/s) characteristic of cluster mergers. The observed distribution of events is best described by timescales of ˜few Myr in agreement with recent numerical simulations of RPS. The broader areal coverage of the Hubble Frontier Fields should provide an even larger sample of RPS events to determine the relative contributions of infall and cluster mergers. Prompted by the discovery of several jellyfish galaxies whose brightness in the F606W passband rivals or exceeds that of the respective brightest cluster galaxy, we attempt to constrain the luminosity function of galaxies undergoing RPS. The observed significant excess at the bright end compared to the luminosity functions of blue cluster members strongly suggests enhanced star formation, thus challenging theoretical and numerical studies according to which RPS merely displaces existing star-forming regions. In-depth studies of individual objects will help test our

VizieR Online Data Catalog: Observations of binary stars at the WIYN telescope (Horch+, 2017)

NASA Astrophysics Data System (ADS)

Horch, E. P.; Casetti-Dinescu, D. I.; Camarata, M. A.; Bidarian, A.; van Altena, W. F.; Sherry, W. H.; Everett, M. E.; Howell, S. B.; Ciardi, D. R.; Henry, T. J.; Nusdeo, D. A.; Winters, J. G.

2018-05-01

The observations were carried out over six runs at the WIYN telescope, specifically, 2010 September 17-21, 2010 October 23-26, 2011 June 11-16, 2011 September 7-11, 2011 December 10-11, and 2012 February 4-8. In each case, an observing list was constructed primarily from HDSs and Hipparcos suspected doubles (ESA 1997ESASP1200.....E), double-lined spectroscopic binary stars identified in the Geneva-Copenhagen spectroscopic survey (Nordstroem et al. 2004, Cat. V/117), and stars we have previously found to be double in our own program and reported in earlier papers in this series. For all observations here, the Differential Speckle Survey Instrument (DSSI) was used (Horch et al. 2009AJ....137.5057H). The instrument can mount to either of the Nasmyth ports of the WIYN telescope and takes speckle observations in two filters simultaneously. The DSSI observing program at WIYN began in 2008, and the instrument was upgraded to use two electron-multiplying CCD cameras in 2010 January. More recently, DSSI have also been used at Lowell Observatory's Discovery Channel Telescope (DCT), and at both the Gemini north and Gemini south telescopes. (3 data files).

Climatic Implications of the Observed Temperature Dependence of the Liquid Water Path of Low Clouds in the Southern Great Plains

NASA Technical Reports Server (NTRS)

DelGenio, Anthony

1999-01-01

Satellite observations of low-level clouds have challenged the assumption that adiabatic liquid water content combined with constant physical thickness will lead to a negative cloud optics feedback in a decadal climate change. We explore the reasons for the satellite results using four years of surface remote sensing data from the Atmospheric Radiation Measurement Program Cloud and Radiation Testbed site in the Southern Great Plains of the United States. We find that low cloud liquid water path is approximately invariant with temperature in winter but decreases strongly with temperature in summer, consistent with the satellite inferences at this latitude. This behavior occurs because liquid water content shows no detectable temperature dependence while cloud physical thickness decreases with warming. Thinning of clouds with warming is observed on seasonal, synoptic, and diurnal time scales; it is most obvious in the warm sectors of baroclinic waves. Although cloud top is observed to slightly descend with warming, the primary cause of thinning, is the ascent of cloud base due to the reduction in surface relative humidity and the concomitant increase in the lifting condensation level of surface air. Low cloud liquid water path is not observed to be a continuous function of temperature. Rather, the behavior we observe is best explained as a transition in the frequency of occurrence of different boundary layer types. At cold temperatures, a mixture of stratified and convective boundary layers is observed, leading to a broad distribution of liquid water path values, while at warm temperatures, only convective boundary layers with small liquid water paths, some of them decoupled, are observed. Our results, combined with the earlier satellite inferences, imply that the commonly quoted 1.5C lower limit for the equilibrium global climate sensitivity to a doubling of CO2 which is based on models with near-adiabatic liquid water behavior and constant physical thickness

Climatic Implications of the Observed Temperature Dependence of the Liquid Water Path of Low Clouds in the Southern Great Plains

NASA Technical Reports Server (NTRS)

DelGenio, Anthony D.; Wolf, Audrey B.

1999-01-01

Satellite observations of low-level clouds have challenged the assumption that adiabatic liquid water content combined with constant physical thickness will lead to a negative cloud optics feedback in a decadal climate change. We explore the reasons for the satellite results using four years of surface remote sensing data from the Atmospheric Radiation Measurement Program Cloud and Radiation Testbed site in the Southern Great Plains of the United States. We find that low cloud liquid water path is approximately invariant with temperature in winter but decreases strongly with temperature in summer, consistent with the satellite inferences at this latitude. This behavior occurs because liquid water content shows no detectable temperature dependence while cloud physical thickness decreases with warming. Thinning of clouds with warming is observed on seasonal, synoptic, and diurnal time scales; it is most obvious in the warm sectors of baroclinic waves. Although cloud top is observed to slightly descend with warming, the primary cause of thinning is the ascent of cloud base due to the reduction in surface relative humidity and the concomitant increase in the lifting condensation level of surface air. Low cloud liquid water path is not observed to be a continuous function of temperature. Rather, the behavior we observe is best explained as a transition in the frequency of occurrence of different boundary layer types: At cold temperatures, a mixture of stratified and convective boundary layers is observed, leading to a broad distribution of liquid water path values, while at warm temperatures, only convective boundary layers with small liquid water paths, some of them decoupled, are observed. Our results, combined with the earlier satellite inferences, imply that the commonly quoted 1.50 C lower limit for the equilibrium global climate sensitivity to a doubling of CO2, which is based on models with near-adiabatic liquid water behavior and constant physical thickness

Doxycycline shows dose-dependent changes in hernia repair strength after mesh repair.

PubMed

Tharappel, Job C; Harris, Jennifer W; Zwischenberger, Brittany A; Levy, Salomon M; Puleo, David A; Roth, J Scott

2016-05-01

Ventral hernia is a commonly occurring surgical problem. Our earlier studies have shown that a 30 mg/kg dose of doxycycline can significantly impact the strength of polypropylene (PP) mesh in a rat hernia repair model at 6 and 12 weeks. The objective of the present study was to investigate the dose dependence of doxycycline treatment on hernia repair strengths in rats. Fifty-six Sprague-Dawley rats underwent hernia repair with either PP mesh (n = 28) or sutures only (primary; n = 28); both groups were further divided into four doxycycline groups of seven animals each: control (0 mg/kg), low (3 mg/kg), medium (10 mg/kg), and high (30 mg/kg). One day before hernia repair surgery, animals received doxycycline doses by gavage and continued receiving daily until euthanasia. After 8 weeks, rats were euthanized and tissue samples from hernia repaired area were collected and analyzed for tensile strength using a tensiometer (Instron, Canton, MA, USA), while MMPs 2, 3, and 9, and collagen type 1 and 3 were analyzed by western blotting. In mesh-repaired animals, medium and high doxycycline dose repaired mesh fascia interface (MFI) showed significant increase in tensile strength when compared to control. In the primary repaired animals, there was no significant difference in MFI tensile strength in any dose group. In medium-dose MFI, there was a significant reduction in MMPs 2, 3, and 9. In this animal group, MFI showed significant increase in collagen 1 and significant reduction in collagen type 3 when compared to control. It is possible to improve the strength of mesh-repaired tissue by administering a significantly lower dose of the drug, which has implications for translation of the findings.

The Gravity Field, Orientation, and Ephemeris of Mercury from MESSENGER Observations After Three Years in Orbit

NASA Technical Reports Server (NTRS)

Mazarico, Erwan M.; Genova, Antonio; Goossens, Sander; Lemoine, Gregory; Neumann, Gregory A.; Zuber, Maria T.; Smith, David E.; Solomon, Sean C.

2014-01-01

We have analyzed three years of radio tracking data from the MESSENGER spacecraft in orbit around Mercury and determined the gravity field, planetary orientation, and ephemeris of the innermost planet. With improvements in spatial coverage, force modeling, and data weighting, we refined an earlier global gravity field both in quality and resolution, and we present here a spherical harmonic solution to degree and order 50. In this field, termed HgM005, uncertainties in low-degree coefficients are reduced by an order of magnitude relative to the earlier global field, and we obtained a preliminary value of the tidal Love number k(sub 2) of 0.451+/-0.014. We also estimated Mercury's pole position, and we obtained an obliquity value of 2.06 +/- 0.16 arcmin, in good agreement with analysis of Earth-based radar observations. From our updated rotation period (58.646146 +/- 0.000011 days) and Mercury ephemeris, we verified experimentally the planet's 3: 2 spin-orbit resonance to greater accuracy than previously possible. We present a detailed analysis of the HgM005 covariance matrix, and we describe some near-circular frozen orbits around Mercury that could be advantageous for future exploration.

Future sea level rise constrained by observations and long-term commitment.

PubMed

Mengel, Matthias; Levermann, Anders; Frieler, Katja; Robinson, Alexander; Marzeion, Ben; Winkelmann, Ricarda

2016-03-08

Sea level has been steadily rising over the past century, predominantly due to anthropogenic climate change. The rate of sea level rise will keep increasing with continued global warming, and, even if temperatures are stabilized through the phasing out of greenhouse gas emissions, sea level is still expected to rise for centuries. This will affect coastal areas worldwide, and robust projections are needed to assess mitigation options and guide adaptation measures. Here we combine the equilibrium response of the main sea level rise contributions with their last century's observed contribution to constrain projections of future sea level rise. Our model is calibrated to a set of observations for each contribution, and the observational and climate uncertainties are combined to produce uncertainty ranges for 21st century sea level rise. We project anthropogenic sea level rise of 28-56 cm, 37-77 cm, and 57-131 cm in 2100 for the greenhouse gas concentration scenarios RCP26, RCP45, and RCP85, respectively. Our uncertainty ranges for total sea level rise overlap with the process-based estimates of the Intergovernmental Panel on Climate Change. The "constrained extrapolation" approach generalizes earlier global semiempirical models and may therefore lead to a better understanding of the discrepancies with process-based projections.

Future sea level rise constrained by observations and long-term commitment

PubMed Central

Mengel, Matthias; Levermann, Anders; Frieler, Katja; Robinson, Alexander; Marzeion, Ben; Winkelmann, Ricarda

2016-01-01

Sea level has been steadily rising over the past century, predominantly due to anthropogenic climate change. The rate of sea level rise will keep increasing with continued global warming, and, even if temperatures are stabilized through the phasing out of greenhouse gas emissions, sea level is still expected to rise for centuries. This will affect coastal areas worldwide, and robust projections are needed to assess mitigation options and guide adaptation measures. Here we combine the equilibrium response of the main sea level rise contributions with their last century's observed contribution to constrain projections of future sea level rise. Our model is calibrated to a set of observations for each contribution, and the observational and climate uncertainties are combined to produce uncertainty ranges for 21st century sea level rise. We project anthropogenic sea level rise of 28–56 cm, 37–77 cm, and 57–131 cm in 2100 for the greenhouse gas concentration scenarios RCP26, RCP45, and RCP85, respectively. Our uncertainty ranges for total sea level rise overlap with the process-based estimates of the Intergovernmental Panel on Climate Change. The “constrained extrapolation” approach generalizes earlier global semiempirical models and may therefore lead to a better understanding of the discrepancies with process-based projections. PMID:26903648

Direct observation of light focusing by single photoreceptor cell nuclei.

PubMed

Błaszczak, Zuzanna; Kreysing, Moritz; Guck, Jochen

2014-05-05

The vertebrate retina is inverted with respect to its optical function, which requires light to pass through the entire tissue prior to detection. The last significant barrier for photons to overcome is the outer nuclear layer formed by photoreceptor cell (PRC) nuclei. Here we experimentally characterise the optical properties of PRC nuclei using bright-field defocusing microscopy to capture near-field intensity distributions behind individual nuclei. We find that some nuclei efficiently focus incident light confirming earlier predictions based on comparative studies of chromatin organisation in nocturnal and diurnal mammals. The emergence of light focusing during the development of mouse nuclei highlights the acquired nature of the observed lens-like behaviour. Optical characterisation of these nuclei is an important first step towards an improved understanding of how light transmission through the retina is influenced by its constituents.

High-resolution observations of the polar magnetic fields of the sun

NASA Technical Reports Server (NTRS)

Lin, H.; Varsik, J.; Zirin, H.

1994-01-01

High-resolution magnetograms of the solar polar region were used for the study of the polar magnetic field. In contrast to low-resolution magnetograph observations which measure the polar magnetic field averaged over a large area, we focused our efforts on the properties of the small magnetic elements in the polar region. Evolution of the filling factor (the ratio of the area occupied by the magnetic elements to the total area) of these magnetic elements, as well as the average magnetic field strength, were studied during the maximum and declining phase of solar cycle 22, from early 1991 to mid-1993. We found that during the sunspot maximum period, the polar regions were occupied by about equal numbers of positive and negative magnetic elements, with equal average field strength. As the solar cycle progresses toward sunspot minimum, the magnetic field elements in the polar region become predominantly of one polarity. The average magnetic field of the dominant polarity elements also increases with the filling factor. In the meanwhile, both the filling factor and the average field strength of the non-dominant polarity elements decrease. The combined effects of the changing filling factors and average field strength produce the observed evolution of the integrated polar flux over the solar cycle. We compared the evolutionary histories of both filling factor and average field strength, for regions of high (70-80 deg) and low (60-70 deg) latitudes. For the south pole, we found no significant evidence of difference in the time of reversal. However, the low-latitude region of the north pole did reverse polarity much earlier than the high-latitude region. It later showed an oscillatory behavior. We suggest this may be caused by the poleward migration of flux from a large active region in 1989 with highly imbalanced flux.

Prediction and Observation of Post-Admission Hematoma Expansion in Patients with Intracerebral Hemorrhage

PubMed Central

Ovesen, Christian; Havsteen, Inger; Rosenbaum, Sverre; Christensen, Hanne

2014-01-01

Post-admission hematoma expansion in patients with intracerebral hemorrhage (ICH) comprises a simultaneous major clinical problem and a possible target for medical intervention. In any case, the ability to predict and observe hematoma expansion is of great clinical importance. We review radiological concepts in predicting and observing post-admission hematoma expansion. Hematoma expansion can be observed within the first 24 h after symptom onset, but predominantly occurs in the early hours. Thus capturing markers of on-going bleeding on imaging techniques could predict hematoma expansion. The spot sign observed on computed tomography angiography is believed to represent on-going bleeding and is to date the most well investigated and reliable radiological predictor of hematoma expansion as well as functional outcome and mortality. On non-contrast CT, the presence of foci of hypoattenuation within the hematoma along with the hematoma-size is reported to be predictive of hematoma expansion and outcome. Because patients tend to arrive earlier to the hospital, a larger fraction of acute ICH-patients must be expected to undergo hematoma expansion. This renders observation and radiological follow-up investigations increasingly relevant. Transcranial duplex sonography has in recent years proven to be able to estimate hematoma volume with good precision and could be a valuable tool in bedside serial observation of acute ICH-patients. Future studies will elucidate, if better prediction and observation of post-admission hematoma expansion can help select patients, who will benefit from hemostatic treatment. PMID:25324825

Earth Observations taken by the Expedition 10 crew

NASA Image and Video Library

2004-11-04

ISS010-E-05803 (4 November 2004) --- Moreno Glacier, Argentina is featured in this digital image photographed by an Expedition 10 crewmember on the International Space Station (ISS). Perito Moreno (or Moreno Glacier) is located in the ice fields of southern Patagonia and is the centerpiece of the Parque Nacional Los Glaciares. The glacier is also noteworthy as a tourist attraction, due to periodic formation of an ice dam between the main portion of Lago (Lake) Argentino to the northeast and a southern extension of the lake (Brazo Rico). NASA scientists studying the Space Station imagery made the following observations about the photo: Meltwater runoff from the surrounding mountains fills Brazo Rico to a higher elevation than nearby Lago Argentino and exerts hydrostatic pressure on the ice dam. This pressure leads to formation of drainage tunnels and fractures in the ice dam, which eventually fails. Earlier this year (March 2004) the ice dam collapsed in a spectacular show. A new ice dam across the Brazo Rico arm of Lago Argentino is visible in this image. The past extent of glaciations in the region is marked by several valleys formerly filled by flowing ice. A particularly striking example of this landscape feature is in the center of the image, where five glacial valleys converge to a central star-shaped outflow valley. Widespread recession of the glaciers in southern Patagonia has occurred over the last 30 years possibly due to warming of the regional climate. Contrary to this trend, Perito Moreno seems to be maintaining equilibrium between ice formation in the mountains and ice loss due to melting and calving into Lago Argentino.

HUBBLE OBSERVES SPIRAL GAS DISK IN ACTIVE GALAXY

NASA Technical Reports Server (NTRS)

2002-01-01

A NASA Hubble Space Telescope image of a spiral-shaped disk of hot gas in the core of active galaxy M87. HST measurements show the disk is rotating so rapidly it contains a massive black hole at its hub. A black hole is an object that is so massive yet compact nothing can escape its gravitational pull, not even light. The object at the center of M87 fits that description. It weights as much as three billion suns, but is concentrated into a space no larger than our solar system. Now that astronomers have seen the signature of the tremendous gravitational field at the center of M87, it is clear that the region contains only a fraction of the number of stars that would be necessary to create such a powerful attraction. The giant elliptical galaxy M87 is located 50 million light-years away in the constellation Virgo. Earlier observations suggested the black hole was present, but were not decisive. A brilliant jet of high- speed electrons that emits from the nucleus (diagonal line across image) is believed to be produced by the black hole 'engine.' The image was taken with HST's Wide Field Planetary Camera 2 Credit: Holland Ford, Space Telescope Science Institute/Johns Hopkins University; Richard Harms, Applied Research Corp.; Zlatan Tsvetanov, Arthur Davidsen, and Gerard Kriss at Johns Hopkins; Ralph Bohlin and George Hartig at Space Telescope Science Institute; Linda Dressel and Ajay K. Kochhar at Applied Research Corp. in Landover, Md.; and Bruce Margon from the University of Washington in Seattle. NASA PHOTO CAPTION STScI-PR94-23a

Testing Numerical Models of Cool Core Galaxy Cluster Formation with X-Ray Observations

NASA Astrophysics Data System (ADS)

Henning, Jason W.; Gantner, Brennan; Burns, Jack O.; Hallman, Eric J.

2009-12-01

Using archival Chandra and ROSAT data along with numerical simulations, we compare the properties of cool core and non-cool core galaxy clusters, paying particular attention to the region beyond the cluster cores. With the use of single and double β-models, we demonstrate a statistically significant difference in the slopes of observed cluster surface brightness profiles while the cluster cores remain indistinguishable between the two cluster types. Additionally, through the use of hardness ratio profiles, we find evidence suggesting cool core clusters are cooler beyond their cores than non-cool core clusters of comparable mass and temperature, both in observed and simulated clusters. The similarities between real and simulated clusters supports a model presented in earlier work by the authors describing differing merger histories between cool core and non-cool core clusters. Discrepancies between real and simulated clusters will inform upcoming numerical models and simulations as to new ways to incorporate feedback in these systems.

Lyman-alpha observations of comet Kohoutek 1973 XII with Copernicus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Drake, J.F.; Jenkins, E.B.; Bertaux, J.L.

1976-10-01

Comet Kohoutek 1973 XII was observed with the Princeton telescope-spectrometer on the Copernicus satellite on six occasions over a 1-month period starting on 1974 January 29. Positive detection of the cometary L..cap alpha.. emission profile was obtained on January 29 and February 2. Earlier observations of the geocoronal L..cap alpha.. emission profile allowed an instrumental intensity calibration and confirmation of the computed instrumental profile for an extended source at the L..cap alpha.. wavelength.After allowing for broadening by the instrument, we derived from the width of the L..cap alpha.. emission on January 29 a hydrogen-outflow velocity of 10.6 +- 1.8 kmmore » s/sup -1/. The intensity calibration combined with an appropriate cometary model led to cometary water-production rates with average values of 1.3 +- 0.4 x 10/sup 28/ molecules sr/sup -1/ s/sup -1/ for January 29 and 6.0 +- 2.5 x 10/sup 27/ molecules sr/sup -1/ s/sup -1/ for February 2. Only upper limits were obtained for L..cap alpha.. on and after February 14. Searches for OH and D led to negative results. (AIP)« less