Changes in detrital input, ventilation and productivity in the central Okhotsk Sea during the marine isotope stage 5e, penultimate interglacial period

NASA Astrophysics Data System (ADS)

Jimenez-Espejo, Francisco J.; García-Alix, Antonio; Harada, Naomi; Bahr, André; Sakai, Saburo; Iijima, Koichi; Chang, Qing; Sato, Keiko; Suzuki, Katsuhiko; Ohkouchi, Naohiko

2018-05-01

By presenting benthic foraminifera isotope profiles and bulk geochemical composition of core sediments, we offer a mutiproxy reconstruction of the central Okhotsk Sea oceanography between ∼130 to and ∼115 kyr, related to the marine isotopic stage 5e (MIS 5e). Sediments from the site MR0604-PC7A have been compared with paleo- sea surface temperatures and other records. This multiparameter approach allowed to recognize three periods for MIS 5e evolution, characterized by variations in marine productivity and bottom oxygenation. These variations have been ultimately associated with the production of Okhotsk Sea Intermediate Water and the presence or absence of nutrient contribution from the Pacific Deep Water into central Okhotsk Sea. Aeolian input reconstructed by Th/Sc ratio indicates higher values during the MIS 6 and MIS 5d compared with the MIS 5e. Eu∗ values indicate an input of detrital material from Kurile Islands and East-Kamchatka during the late MIS 5e, absent during the early MIS 5e and glacial periods.

Foraminifera eco-biostratigraphy of the southern Evoikos outer shelf, central Aegean Sea, during MIS 5 to present

NASA Astrophysics Data System (ADS)

Drinia, Hara; Antonarakou, Assimina; Tsourou, Theodora; Kontakiotis, George; Psychogiou, Maria; Anastasakis, George

2016-09-01

The South Evoikos Basin is a marginal basin in the Aegean Sea which receives little terrigenous supply and its sedimentation is dominated by hemipelagic processes. Late Quaternary benthic and planktonic foraminifera from core PAG-155 are investigated in order to understand their response to the glacial-interglacial cycles in this region. The quantitative analysis of planktonic foraminifera, coupled with accelerator mass spectrometry (14C-AMS) radiocarbon date measurements, provide an integrated chrono-stratigraphic time framework over the last 90 ka (time interval between late Marine Isotopic Stages 5 and 1; MIS5-MIS1). The temporary appearance and disappearance as well as several abundance peaks in the quantitative distribution of selected climate-sensitive planktonic species allowed the identification of several eco-bioevents, useful to accurately mark the boundaries of the eco-biozones widely recognized in the Mediterranean records and used for large-scale correlations. The established bio-ecozonation scheme allows a detailed palaecological reconstruction for the late Pleistocene archive in the central Aegean, and furthermore provides a notable contribution for palaeoclimatic studies, facilitating intercorrelations between various oceanographic basins. The quantitative analyses of benthic foraminifera identify four distinct assemblages, namely Biofacies: Elphidium spp., Haynesina spp. Biofacies, characterized by neritic species, dominated during the transition from MIS 5 to MIS 4; Cassidulina laevigata/carinata Biofacies dominated till 42 ka (transgressive trend from MIS 4 to MIS 3); Bulimina gibba Biofacies dominated from 42 ka to 9.5 ka (extensive regression MIS 3,2 through lowstand and early transgression; beginning of MIS 1); Bulimina marginata, Uvigerina spp. Biofacies dominated from 9.5 ka to the present (late transgression through early highstand; MIS 1)., This study showed that the South Evoikos Basin which is characterized by its critical depths and

Quantitative reconstruction of precipitation and runoff during MIS 5a, MIS 3a, and Holocene, arid China

NASA Astrophysics Data System (ADS)

Liu, Yuan; Li, Yu

2017-11-01

Marine oxygen isotope stage 5a (MIS 5a), MIS 3a, and Holocene were highlighted periods in paleoclimate studies. Many scientists have published a great number of studies in this regard, but they paid more attention to qualitative research, and there was often a lack of quantitative data. In this paper, based on chronological evidence from a paleolake in arid China, MIS 5a, MIS 3a, and Holocene lake area, the precipitation of the drainage area and the runoff of the inflowing rivers of the lake were reconstructed with ArcGIS spatial analysis software and the improved water and energy balance model which was calibrated by modern meteorological and hydrological data in the Shiyang River drainage basin. The results showed that the paleolake areas were 1824, 1124, and 628 km2 for MIS 5a, MIS 3a, and Holocene; meanwhile, the paleoprecipitation and runoff were 293.992-297.433, 271.105-274.294, and 249.431-252.373 mm and 29.103 × 108-29.496 × 108, 18.810 × 108-18.959 × 108, and 10.637 × 108-10.777 × 108 mm, respectively. The quantitative data can help us not only strengthen the understanding of paleoclimatic characteristics but also recognize the complexity and diversity of the climate system.

Cueva Antón: A multi-proxy MIS 3 to MIS 5a paleoenvironmental record for SE Iberia

NASA Astrophysics Data System (ADS)

Zilhão, João; Ajas, Aurélie; Badal, Ernestina; Burow, Christoph; Kehl, Martin; López-Sáez, José Antonio; Pimenta, Carlos; Preece, Richard C.; Sanchis, Alfred; Sanz, Montserrat; Weniger, Gerd-Christian; White, Dustin; Wood, Rachel; Angelucci, Diego E.; Villaverde, Valentín; Zapata, Josefina

2016-08-01

Overlying a palustrine deposit of unknown age (complex FP), and protected from weathering and erosion inside a large cave/rock-shelter cavity, the sedimentary fill of Cueva Antón, a Middle Paleolithic site in SE Spain, corresponds in most part (sub-complexes AS2-to-AS5) to a ca.3 m-thick Upper Pleistocene terrace of the River Mula. Coupled with the constraints derived from the deposit's paleoclimatic proxies, OSL dating places the accumulation of this terrace in MIS 5a, and radiocarbon dates from the overlying breccia cum alluvium (sub-complex AS1) fall in the middle part of MIS 3; the intervening hiatus relates to valley incision and attendant erosion. The two intervals represented remain largely unknown in Iberia, where the archeology of the early-to-middle Upper Pleistocene is almost entirely derived from karst sites; Cueva Antón shows that this dearth of data, often interpreted in demographic terms, has depositional underpinnings ultimately determined by past climate variation. In early MIS 5a, the paleobotanical evidence indicates climate conditions similar to present, albeit wetter, followed by progressive cooling, reflected in the replacement of Aleppo pine by black pine and, at the very end, juniper-dominated landscapes - the latter characterizing also mid-MIS 3 times. The variation in sedimentary facies and composition of the mollusk assemblages reflects the changing position of the river channel relative to the back wall of the cave. Such changes represented the major constraint for the occupation of the site - most of the time inaccessible to terrestrial mammals, it was used throughout by the eagle-owl, explaining the abundance of rabbit bones. Human occupation occurred during a few, short windows of availability, and is reflected in well-preserved living floors defined by hearths, artefact scatters, and the remains of hunted herbivores. The stone tool assemblages are Middle Paleolithic, which, in Europe, implies a Neandertal identity for their makers

Climate and vegetation since the Last Interglacial (MIS 5e) in a putative glacial refugium, northern Idaho, USA

NASA Astrophysics Data System (ADS)

Herring, Erin M.; Gavin, Daniel G.

2015-06-01

There are very few terrestrial sediment records from North America that contain a nearly continuous sequence spanning from the Last Interglacial period to the present. We present stratigraphic records of pollen and several other proxies from a Carex-dominated wetland, Star Meadows, located 140 km south of the maximum extent of the Cordilleran Ice Sheet and near the current southern extent of interior mesic forests in northern Idaho. Many species in this region are disjunct by 160 km of arid steppe and dry forest from their more extensive distribution along the Pacific Northwest coast and may have survived in an interior refugium. The chronology for the upper 251 cm was determined by six radiocarbon dates and one tephra deposit, and the age of the remainder of the core (251-809 cm) was estimated by correlation with SPECMAP δ18O. Fluctuating water levels were inferred from alternating peat, biogenic silica, and aquatic pollen types. During MIS 5e the region was warmer and drier than today and was dominated by Pinus (likely Pinus contorta) mixed conifer forest surrounding a Carex meadow. A cool-moist climate (MIS 5b-5d) soon developed, and the site was inundated with deep water. Pollen indicated wetland vegetation (Betula glandulosa, Typhaceae, and Salix) developed around a lake with a Pseudotsuga/Larix and Picea forest on the surrounding slopes. During MIS 5a, a warmer climate supported a Pseudotsuga/Larix, Abies, and Picea forest on the surrounding hillsides and a Carex-dominated environment within a dry meadow. From MIS 4 to MIS 3, a cool and wet Pinus and Picea forest predominated. Water levels rose, enabling Nuphar to persist within a perennial lake while a sedge fen established along the lake margin. As climate transitioned into MIS 2, a cooler and drier climate supported a Pinus and Picea subalpine parkland, though water levels remained high enough to support Nuphar. During the Last Glacial Maximum the sediment was mainly silt and clay with high Artemisia and

Superstorms at the end of the Last Interglacial (MIS 5e)? Modeling paleo waves and the transport of giant boulders.

NASA Astrophysics Data System (ADS)

Rovere, Alessio; Harris, Daniel; Casella, Elisa; Lorscheid, Thomas; Stocchi, Paolo; Nandasena, Napayalage; Sandstrom, Michael; D'Andrea, William; Dyer, Blake; Raymo, Maureen

2017-04-01

We present the results of high-resolution field surveys and wave models along the cliffs of the northern part of the Island of Eleuthera, Bahamas. Previous studies have proposed that cliff top mega-boulders were emplaced at the end of the Last Interglacial (MIS 5e, 128-116 ka) by giant swells caused by super-storms that find no counterpart in the Holocene (including historical times). Our results suggest that these boulders could have instead been transported from the cliff face to the top of the cliff by a storm analogous to the 1991 'Perfect Storm', if sea level during MIS 5e sea was more than 4 meters higher than today. We remark that the data-model approach used here is essential to interpreting the geologic evidence of extreme storms during past warm periods, which in turn, is an important tool for predicting the intensity of extreme storm events in future climates. Our results indicate that even without an increase in storm intensity, cliffs and hard coastal barriers might be subject to significant increases wave-generated stresses under conditions of sea levels modestly higher than present.

Multiproxy record of the last interglacial (MIS 5e) off central and northern California, U.S.A., from Ocean Drilling Program sites 1018 and 1020

USGS Publications Warehouse

Poore, Richard Z.; Dowsett, H.J.; Barron, J.A.; Heusser, L.; Ravelo, A.C.; Mix, A.

2000-01-01

Environmental and climatic conditions during the last interglacial (about 125,000 years ago) along the Central and Northern California coastal region are interpreted from study of marine cores recovered by the Ocean Drilling Program at sites 1018 and 1020. Marine microfossil and pollen assemblages, oxygen isotopes in benthic foraminifers, physical properties, and calcium carbonate contents of cored sediments are proxies indicating strong links between the marine and terrestrial environments during marine isotope stage 5 (MIS 5). At the beginning of the last interglacial (MIS 5e), reduction in global ice volume, increase in surface temperature, and warming of air temperature along the Central and Northern California coast were synchronous within the resolution of our sampling record.

Similar millennial climate variability on the Iberian margin during two early Pleistocene glacials and MIS 3

NASA Astrophysics Data System (ADS)

Birner, B.; Hodell, D. A.; Tzedakis, P. C.; Skinner, L. C.

2016-01-01

Although millennial-scale climate variability (<10 ka) has been well studied during the last glacial cycles, little is known about this important aspect of climate in the early Pleistocene, prior to the Middle Pleistocene Transition. Here we present an early Pleistocene climate record at centennial resolution for two representative glacials (marine isotope stages (MIS) 37-41 from approximately 1235 to 1320 ka) during the "41 ka world" at Integrated Ocean Drilling Program Site U1385 (the "Shackleton Site") on the southwest Iberian margin. Millennial-scale climate variability was suppressed during interglacial periods (MIS 37, MIS 39, and MIS 41) and activated during glacial inceptions when benthic δ18O exceeded 3.2‰. Millennial variability during glacials MIS 38 and MIS 40 closely resembled Dansgaard-Oeschger events from the last glacial (MIS 3) in amplitude, shape, and pacing. The phasing of oxygen and carbon isotope variability is consistent with an active oceanic thermal bipolar see-saw between the Northern and Southern Hemispheres during most of the prominent stadials. Surface cooling was associated with systematic decreases in benthic carbon isotopes, indicating concomitant changes in the meridional overturning circulation. A comparison to other North Atlantic records of ice rafting during the early Pleistocene suggests that freshwater forcing, as proposed for the late Pleistocene, was involved in triggering or amplifying perturbations of the North Atlantic circulation that elicited a bipolar see-saw response. Our findings support similarities in the operation of the climate system occurring on millennial time scales before and after the Middle Pleistocene Transition despite the increases in global ice volume and duration of the glacial cycles.

Lake level fluctuations and catchment dynamics at Lake Ohrid (Macedonia, Albania) during MIS6 and MIS5

NASA Astrophysics Data System (ADS)

Francke, Alexander; Wagner, Bernd; Just, Janna; Sadori, Laura; Masi, Alessia; Vogel, Hendrik; Lindhorst, Katja; Krastel, Sebastian; Dosseto, Anthony; Rothacker, Leo; Leicher, Niklas; Gromig, Raphael

2016-04-01

Lake Ohrid, presumably the oldest lake of Europe located at the border of Macedonia and Albania, is about 30 km long, 15 km wide, and up to 290 m deep. In 2013, an ICDP deep drilling campaign was carried out under the umbrella of the Scientific Collaboration on Past Speciation Conditions in Lake Ohrid (SCOPSCO) project. At the main drill site (DEEP) in the central part of Lake Ohrid, the uppermost 568 m from a total sediment fill of ca. 700 m were recovered. Initial data from core catcher material indicate that the sediment sequence covers more than 1.2 million years. An age model, which is based on 11 tephrostratigragphic tie points and on tuning of biogeochemical proxy data versus orbital parameters reveals that that the upper 247 m of the DEEP site sequence cover the time period between 637 ka (MIS16) and the present. Inhere, we present sedimentological, (bio-)geochemical, environmental magnetic, and pollen data for the time period between MIS6 (191 ka) and MIS5 (71 ka). The data imply that MIS6 was one of the most severe glacial periods, while MIS5 was likely one of the more pronounced interglacial during the past 637 kyrs. The repercussions of these high amplitude climatic and environmental variations during this period are recorded in the sedimentological archive of Lake Ohrid. Previous studies based on hydro-acoustic and sediment core data from the northeastern part of the lake basin have shown that the lake level of Lake Ohrid was likely 60 m lower during MIS6. The ˜60 m lower lake level at Lake Ohrid during MIS6 can at least partly be explained by the ongoing subsidence, which persists in the basin until today. However, in the DEEP site sediments, the MIS6/MIS5 transition occurs at ca. 50 m sediment depth. This implies that climate-induced lake level fluctuation at Lake Ohrid are less severe compared for example to Lake Van (Turkey), were a 260 m lower lake level has been reported for the Younger Dryas. The imprint of the environmental variations between

Tsunami deposits at MIS Stages 5e and 9 on Oahu, Hawaii: implications for sea level at interglacial stages

NASA Astrophysics Data System (ADS)

McMurtry, G. M.; Campbell, J. F.; Fryer, G. J.; Tappin, D. R.; Fietzke, J.

2010-12-01

Sandy, basalt-coral conglomerates associated with both beachrock and coral reefs are found at high elevations on Oahu, Hawaii. They have been attributed to either brief, sea level high-stands or storms. The Kahe Point conglomerates are at 12.5 m elevation, whereas the main stage MIS-5e reef at this location has a maximum elevation of 8.2 m. They are loosely consolidated and poorly cemented, graded, poorly sorted, and with varying amounts of basalt and coral clasts ranging from cobble to boulder size. Coral in these deposits has been U-series dated by us at between 120-125 ka (n=5). Four distinct beds, with a gently seaward tilt, are recognized in a road cut section, with each bed composed of a few cm-thick topset bed of fine-grained, shelly, calcareous sand to silt. Similar high elevation conglomerates and 5e reefs are also described at Mokapu and Kaena Points on Oahu, indicating an island-wide deposit. Older coral clasts, dated at 130 to 142 ka (n=6; oldest by alpha spectrometry) found in association with the stage 5e corals suggest reworking and incorporation of older low-stand reef material. The coarse grain size of the conglomerates indicates deposition from a high-energy event; thus a high-stand source is ruled out. We also consider that the overall lithology and up to 0.5 m bed thickness not to be the result of storms; a series of high frequency storm events is considered unlikely. The weight of the evidence in our opinion clearly indicates deposition by a series of tsunami waves. If correct, this has implications for “probabilistic” models of sea level peaks at least 6.6 m higher than present at stage 5e that use such data in their models (e. g., Kopp et al., 2009), at least for Oahu. Within about 2 km of the Kahe deposit, in a road cut at Ko Olina, there is another markedly similar high-energy, sandy basalt-bearing coral conglomerate sequence at 21 to 25 m elevation. There are at least two distinct beds about one meter in thickness, both gently seaward

Relative sea-level changes and glacio-isostatic adjustment on the Magdalen Islands archipelago (Atlantic Canada) from MIS 5 to the late Holocene

NASA Astrophysics Data System (ADS)

Rémillard, Audrey M.; St-Onge, Guillaume; Bernatchez, Pascal; Hétu, Bernard; Buylaert, Jan-Pieter; Murray, Andrew S.; Lajeunesse, Patrick

2017-09-01

The Magdalen Islands (Québec, Canada) in the centre of the Gulf of St. Lawrence are located in a strategic position for providing an overview of the relative sea-level (RSL) history of the Maritime Provinces of eastern Canada. Although data are available for the coastal terrestrial areas of the Maritimes, data from the Gulf are very scarce and both the RSL and glacio-isostatic adjustment (GIA) models extrapolate for this central region. This study provides new stratigraphic and chronological data from four outcrops and two coring sites on the Magdalen Islands. In addition to the five samples used mainly for age control purposes, nine new luminescence ages are presented. With these new data added to the available literature, a new RSL curve is reconstructed for the LGM to the late Holocene period and a partial curve is proposed for the interval between the late MIS 4 to the MIS 3. Data also indicate a few insights for the MIS 5 period. Results reveal that for the LGM to the late Holocene, the curve corresponds to the J-shaped curve scenario recognized in the literature. The RSL changes during this period are the result of glacio-isostatic rebound, migration and collapse of the peripheral forebulge, and eustatic sea-level changes. For the LGM to the early Holocene, glacio-isostatic depression curves displaying a few local differences are also proposed. For the late Holocene, the data constrain the curve between two types of indicators, i.e. marine and terrestrial, and indicate that the RSL has risen at least 3 m during the last two millennia. Sediments dated to the MIS 5 and the interval between the late MIS 4 and the MIS 3 illustrate that the GIA following the LGM also occurred for the MIS 5 interglacial and the MIS 3 interstadial. Finally, recent GIA models are discussed in light of the results of this paper.

MIS 5e sea level: up to what point can we use literature reviews to answer the most pressing questions on the Last Interglacial ice sheets?

NASA Astrophysics Data System (ADS)

Rovere, A.; Raymo, M. E.

2014-12-01

During MIS 5e (between ~128 and 116 kyr BP) greenhouse gas concentrations were comparable to pre-industrial levels, summer insolation was higher by ~10% at high latitudes and polar temperatures in both hemispheres were about 3-5 °C warmer than today. Sea level (SL) at this time has been a subject of numerous studies (and some debate) with ~1000 sites with MIS 5e sea level markers recognized worldwide. Recently, Kopp et al. (Nature, 2009) and Dutton & Lambeck (Science, 2012) analyzed worldwide datasets of sea level markers pertaining to the last interglacial. After accounting for GIA, they reached similar conclusions that eustatic (i.e., globally averaged) sea level (ESL) was between +5 and +9.4 m above modern during MIS 5e. Furthermore, Kopp et al. (Nature, 2009; GJI, 2013) suggest that sea level was not uniform during the LIG, but instead underwent at least two rapid oscillations including a rapid late 5e rise first proposed by Hearty et al. (QSR, 2007) and later by O'Leary et al. (Nat. Geo., 2013). Investigating the temporal and geographic variability of MIS 5e sea level opens new lines of research, in particular the possibility to fingerprint (Hay et al., QSR, 2014) the source of the proposed rapid ice sheet collapse near the end of the Last Interglacial. In this presentation we ask: can we use a database of published sea level estimates for this purpose? To answer this question, we built a relative sea level (RSL) database using RSLcalc 2.0; this is a relational database specifically designed to review relative sea level data points while keeping all the relevant information contained in the original publications. RSlcalc allows to estimate the measurement error (on the actual elevation of the SL feature), the error on the indicative range (the elevation range occupied by a sea level indicator) as well as the reference water level (the relationship between the marker and the former sea level). We show that the majority of published data have an accuracy of few

Speleothem records of changes in the South American Summer Monsoon during MIS stages 5 and 6

NASA Astrophysics Data System (ADS)

Burns, S. J.; Kanner, L.; Cheng, H.; Edwards, R.

2011-12-01

Little information exists about the behavior of the South American Summer Monsoon prior to the Last Glacial Period. Speleothems from the Peruvian Altiplano are one possible archive of SASM intensity because oxygen isotopes of rainfall on the Altiplano are primarily controlled by the intensity of rainfall in upstream moisture source region, the Amazon Basin. Here, we present results from a two speleothems collected from Gruta de Huagapo, a cave in the central Peruvian Altiplano (12°S, 76°W, ~3800m elevation). The samples grew from approximately 115-125 ky BP and from 136-168 ky BP, spanning time periods equivalent to much of MIS stage 5e and the transition into MIS 5d and MIS 6. Chronologies were determined by U-Th dating techniques and the dates are in stratigraphic with analytical errors < 0.4%. 100 preliminary δ18O values were micromilled from each sample along the growth axis. Oxygen isotopic values of the younger sample, stalagmite P10-H1, range from -12.5% to -16.5%. The overall trend in isotopic values generally parallels summer insolation, with more depleted values associated with greater insolation. The most enriched values, between -12.5% and -13.5% occur from 121-125 ky BP, with an abrupt transition to more depleted values at 121 ky BP. The values plateau at about -15% until 117 ky BP, then abruptly decrease again to around -16 % for the rest of the record. The enriched values during the middle and latter parts of MIS 5e suggest a weakened monsoon during that time and coincide with observed low lake levels at Lake Titicaca (Fritz et al, 2007). At present we have isotopic data from only the youngest 10 ky of the older sample. The values are generally more depleted, with most between -16% and -17%, suggesting an intensified SASM during MIS 6 as compared to 5e. A rapid increase in δ18O occurs at ~136 ky BP. Overall the trends in the data parallel major changes in δD from EPICA, but appear to lead the Antarctic time series by ~2 ky.

Final validation of the ProMisE molecular classifier for endometrial carcinoma in a large population-based case series.

PubMed

Kommoss, S; McConechy, M K; Kommoss, F; Leung, S; Bunz, A; Magrill, J; Britton, H; Kommoss, F; Grevenkamp, F; Karnezis, A; Yang, W; Lum, A; Krämer, B; Taran, F; Staebler, A; Lax, S; Brucker, S Y; Huntsman, D G; Gilks, C B; McAlpine, J N; Talhouk, A

2018-05-01

We have previously developed and confirmed a pragmatic molecular classifier for endometrial cancers; ProMisE (Proactive Molecular Risk Classifier for Endometrial Cancer). Inspired by the Cancer Genome Atlas, ProMisE identifies four prognostically distinct molecular subtypes and can be applied to diagnostic specimens (biopsy/curettings) enabling earlier informed decision-making. We have strictly adhered to the Institute of Medicine (IOM) guidelines for the development of genomic biomarkers, and herein present the final validation step of a locked-down classifier before clinical application. We assessed a retrospective cohort of women from the Tübingen University Women's Hospital treated for endometrial carcinoma between 2003 and 2013. Primary outcomes of overall, disease-specific, and progression-free survival were evaluated for clinical, pathological, and molecular features. Complete clinical and molecular data were evaluable from 452 women. Patient age ranged from 29 to 93 (median 65) years, and 87.8% cases were endometrioid histotype. Grade distribution included 282 (62.4%) G1, 75 (16.6%) G2, and 95 (21.0%) G3 tumors. 276 (61.1%) patients had stage IA disease, with the remaining stage IB [89 (19.7%)], stage II [26 (5.8%)], and stage III/IV [61 (13.5%)]. ProMisE molecular classification yielded 127 (28.1%) MMR-D, 42 (9.3%) POLE, 55 (12.2%) p53abn, and 228 (50.4%) p53wt. ProMisE was a prognostic marker for progression-free (P = 0.001) and disease-specific (P = 0.03) survival even after adjusting for known risk factors. Concordance between diagnostic and surgical specimens was highly favorable; accuracy 0.91, κ 0.88. We have developed, confirmed, and now validated a pragmatic molecular classification tool (ProMisE) that provides consistent categorization of tumors and identifies four distinct prognostic molecular subtypes. ProMisE can be applied to diagnostic samples and thus could be used to inform surgical procedure(s) and/or need for adjuvant therapy

Coral Reef Response to Marine Isotope Stage (MIS) 5e Sea Level Changes in the Granitic Seychelles

NASA Astrophysics Data System (ADS)

Vyverberg, K.; Dechnik, B.; Dutton, A.; Webster, J.; Zwartz, D.

2015-12-01

Sea-level position has a direct control on coral reef morphology and composition. Examining changes in these parameters in fossil reefs can inform reconstructions of past sea-level behavior and, indirectly, ice sheet dynamics. Here we provide a detailed examination of fossil reefs from Marine Isotope Stage (MIS) 5e. These fossil reefs are located in the granitic Seychelles, which is tectonically stable site and far-field from the former margins of Northern Hemisphere ice sheets. To reconstruct relative sea level (RSL), we combine RTK and Total Station elevation surveys with sedimentary and taxonomic evaluations of eight fossil reef sites. Carbonate coralgal reef buildups of the shallowest portion of the reef are preserved in limestone outcrops that are protected by granite boulder overhangs. Two primary outcrop morphologies were observed at these sites: plastering and massive. Plastering outcrops manifest as thin (~ 1 m height x 1 m width x 0.5 m depth) vertical successions of reef framework and detritus, while massive outcrops are larger (~ 2-6 m height x 2-6 m width x 1-2 m depth). The base of these limestone outcrops consistently record a period of reef growth, characterized by corals or coralline algae colonizing the surface or face of a granite boulder and building upwards. This lower reefal unit is capped by a disconformity that is commonly overlain by coral rubble or a ~10 cm thick layer of micrite. Rubble units contain coarse fragments of the coralgal reef buildups while micrite layers consist of a relatively homogeneous fine-grained carbonate, bearing coral-dwelling, Pyrgomatid barnacles. In many of the outcrops, this succession is repeated upsection with another unit of coralgal reef framework capped by a disconformity that is recognized by the sharp transition to coral rubble or micrite with barnacles. We identified four distinct fossil coralgal assemblages in the limestone outcrops. These assemblages are consistent with modern assemblages which

Red Sea circulation during marine isotope stage 5e

NASA Astrophysics Data System (ADS)

Siccha, Michael; Biton, Eli; Gildor, Hezi

2015-04-01

We have employed a regional Massachusetts Institute of Technology oceanic general circulation model of the Red Sea to investigate its circulation during marine isotope stage (MIS) 5e, the peak of the last interglacial, approximately 125 ka before present. Compared to present-day conditions, MIS 5e was characterized by higher Northern Hemisphere summer insolation, accompanied by increases in air temperature of more than 2°C and global sea level approximately 8 m higher than today. As a consequence of the increased seasonality, intensified monsoonal conditions with increased winds, rainfall, and humidity in the Red Sea region are evident in speleothem records and supported by model simulations. To assess the dominant factors responsible for the observed changes, we conducted several sensitivity experiments in which the MIS 5 boundary conditions or forcing parameters were used individually. Overall, our model simulation for the last interglacial maximum reconstructs a Red Sea that is colder, less ventilated and probably more oligotrophic than at present day. The largest alteration in Red Sea circulation and properties was found for the simulation of the northward displacement and intensification of the African tropical rain belt during MIS 5e, leading to a notable increase in the fresh water flux into the Red Sea. Such an increase significantly reduced the Red Sea salinity and exchange volume of the Red Sea with the Gulf of Aden. The Red Sea reacted to the MIS 5e insolation forcing by the expected increase in seasonal sea surface temperature amplitude and overall cooling caused by lower temperatures during deep water formation in winter.

Climate and hydrology of the last interglaciation (MIS 5) in Owens Basin, California: Isotopic and geochemical evidence from core OL-92

USGS Publications Warehouse

Li, H.-C.; Bischoff, J.L.; Ku, T.-L.; Zhu, Z.-Y.

2004-01-01

??18O, ??13C, total organic carbon, total inorganic carbon, and acid-leachable Li, Mg and Sr concentrations on 443 samples from 32 to 83 m depth in Owens Lake core OL-92 were analyzed to study the climatic and hydrological conditions between 60 and 155 ka with a resolution of ???200 a. The multi-proxy data show that Owens Lake overflowed during wet/cold conditions of marine isotope stages (MIS) 4, 5b and 6, and was closed during the dry/warm conditions of MIS 5a, c and e. The lake partially overflowed during MIS 5d. Our age model places the MIS 4/5 boundary at ca 72.5 ka and the MIS 5/6 boundary (Termination II) at ca 140 ka, agreeing with the Devils Hole chronology. The diametrical precipitation intensities between the Great Basin (cold/wet) and eastern China (cold/dry) on Milankovitch time scales imply a climatic teleconnection across the Pacific. It also probably reflects the effect of high-latitude ice sheets on the southward shifts of both the summer monsoon frontal zone in eastern Asia and the polar jet stream in western North America during glacial periods. ?? 2003 Elsevier Ltd. All rights reserved.

Multidecadally resolved Asian summer monsoon dynamics during MIS 5a-5d

NASA Astrophysics Data System (ADS)

Shen, C. C.; Jiang, X.; Hu, H. M.; Spoetl, C.

2016-12-01

A strong correlation between the Asian summer monsoon (ASM) and the North Atlantic climate on millennial and sub-millennial timescales during the last glacial period (MIS 4-2) and deglacial sequence has been demonstrated. However, our knowledge of this millennial- and sub-millennial-scale climatic link before MIS 4 is limited. Here, we present a new U-Th-dated absolute chronology of ASM variability from 113.5 to 86.6 kyr BP, covering marine isotope stages (MIS) 5a-5d. This integrated multidecadally resolved record, based on 1435 oxygen isotope data and 46 U-Th dates with 2-sigma errors as low as ±0.3 kyr from three stalagmites collected in Sanxing Cave, southwestern China, can be a reference for calibrating paleoclimate proxy sequences. The Sanxing oxygen isotope record follows the 23 kyr precessional cycle of insolation and is punctuated by prominent millennial-scale oscillations of the Chinese Interstadials (CIS) 25 to 22, corresponding to Greenland Interstadials (GIS) 25 to 22. A centennial-scale precursor event at 104.1 ± 0.3 kyr BP preceding CIS 23 is clearly registered. These events in the Sanxing record are synchronous with those identified in stalagmites from the European Alps (NALPS), except for the onset of GIS 25 and the end of GIS 22, and are up to 2.3 kyr older than the corresponding ones in Greenland ice core records. The high degree of similarity of the oxygen isotope records between Sanxing Cave and Greenland supports the northern hemisphere forcing of the ASM. The anti-phase relationship of oxygen isotope records between Sanxing stalagmites and Antarctic ice cores suggests an additional ASM linkage to the Southern Hemisphere.

New sea-level data of the MIS 5e interglacial of Mallorca Island, Spain

NASA Astrophysics Data System (ADS)

Lorscheid, Thomas; Stocchi, Paolo; de Boer, Bas; Mann, Thomas; Westphal, Hildegard; Rovere, Alessio

2015-04-01

The island of Mallorca (Balearic Islands, Spain) is one of the key locations in the Western Mediterranean for the study of Last Interglacial sea levels. Although MIS 5e deposits and landforms have been investigated by several authors since Cuerda (1979), most former studies concentrate on few outcrops. Although description of fossils, facies and age attribution for these outcrops are known in detail, these sites have never been the object of differential GPS measurements and glacial isostatic adjustment effects have never been taken into consideration. In this study, we present the results of fieldwork at several outcrops around the Island of Mallorca. We measured the elevation of deposits and landforms associated with the Last Interglacial with a high-precision GPS-system, and we calculated for each the reference water level and indicative range using modern analogs along the same shorelines. Moreover, we took samples of some outcrops for radiometric dating. The outcrops consist mainly of beach deposits at 1-3 m apsl and one elevated deposit in the Southeast of the island at 8 m apsl. We use an earth-ice coupled GIA-model for the Mediterranean to compare the elevation of our deposits to expected GIA signal in this region and discuss our results in terms of tectonics and eustasy.

Ice Complex permafrost of MIS5 age in the Dmitry Laptev Strait coastal region (East Siberian Arctic)

NASA Astrophysics Data System (ADS)

Wetterich, Sebastian; Tumskoy, Vladimir; Rudaya, Natalia; Kuznetsov, Vladislav; Maksimov, Fedor; Opel, Thomas; Meyer, Hanno; Andreev, Andrei A.; Schirrmeister, Lutz

2016-09-01

Ice Complex deposits (locally known as the Buchchagy Ice Complex) are exposed at both coasts of the East Siberian Dmitry Laptev Strait and preserved below the Yedoma Ice Complex that formed during MIS3 and MIS2 (Marine Isotope Stage) and lateglacial-Holocene thermokarst deposits (MIS1). Radioisotope disequilibria (230Th/U) of peaty horizons date the Buchchagy Ice Complex deposition to 126 + 16/-13 kyr and 117 + 19/-14 kyr until 98 ± 5 kyr and 89 ± 5 kyr. The deposit is characterised by poorly-sorted medium-to-coarse silts with cryogenic structures of horizontal ice bands, lens-like, and lens-like reticulated segregation ice. Two peaty horizons within the Buchchagy Ice Complex and syngenetic ice wedges (2-4 m wide, up to 10 m high) are striking. The isotopic composition (δ18O, δD) of Buchchagy ice-wedge ice indicates winter conditions colder than during the MIS3 interstadial and warmer than during MIS2 stadial, and similar atmospheric winter moisture sources as during the MIS2 stadial. Buchchagy Ice Complex pollen spectra reveal tundra-steppe vegetation and harsher summer conditions than during the MIS3 interstadial and rather similar vegetation as during the MIS2 stadial. Short-term climatic variability during MIS5 is reflected in the record. Even though the regional chronostratigraphic relationship of the Buchchagy Ice Complex to the Last Interglacial remains unclear because numerical dating is widely lacking, the present study indicates permafrost (Ice Complex) formation during MIS5 sensu lato, and its preservation afterwards. Palaeoenvironmental insights into past climate and the periglacial landscape dynamics of arctic lowlands in eastern Siberia are deduced from the record.

Early Wisconsinan (MIS 4) Arctic ground squirrel middens and a squirrel-eye-view of the mammoth-steppe

NASA Astrophysics Data System (ADS)

Zazula, Grant D.; Froese, Duane G.; Elias, Scott A.; Kuzmina, Svetlana; Mathewes, Rolf W.

2011-08-01

Fossil arctic ground squirrel ( Spermophilus parryii) middens were recovered from ice-rich loess sediments in association with Sheep Creek-Klondike and Dominion Creek tephras (ca 80 ka) exposed in west-central Yukon. These middens provide plant and insect macrofossil evidence for a steppe-tundra ecosystem during the Early Wisconsinan (MIS 4) glacial interval. Midden plant and insect macrofossil data are compared with those previously published for Late Wisconsinan middens dating to ˜25-29 14C ka BP (MIS 3/2) from the region. Although multivariate statistical comparisons suggest differences between the relative abundances of plant macrofossils, the co-occurrence of steppe-tundra plants and insects (e.g., Elymus trachycaulus, Kobresia myosuroides, Artemisia frigida, Phlox hoodii, Connatichela artemisiae) provides evidence for successive reestablishment of the zonal steppe-tundra habitats during cold stages of the Late Pleistocene. Arctic ground squirrels were well adapted to the cold, arid climates, steppe-tundra vegetation and well-drained loessal soils that characterize cold stages of Late Pleistocene Beringia. These glacial conditions enabled arctic ground squirrel populations to expand their range to the interior regions of Alaska and Yukon, including the Klondike, where they are absent today. Arctic ground squirrels have endured numerous Quaternary climate oscillations by retracting populations to disjunct "interglacial refugia" during warm interglacial periods (e.g., south-facing steppe slopes, well-drained arctic and alpine tundra areas) and expanding their distribution across the mammoth-steppe biome during cold, arid glacial intervals.

A MIS 9/MIS 8 speleothem record of hydrological variability from Macedonia (F.Y.R.O.M.)

NASA Astrophysics Data System (ADS)

Regattieri, Eleonora; Zanchetta, Giovanni; Isola, Ilaria; Bajo, Petra; Perchiazzi, Natale; Drysdale, Russell N.; Boschi, Chiara; Hellstrom, John C.; Francke, Alexander; Wagner, Bernd

2018-03-01

The period corresponding to Marine Isotope Stages 9 (MIS 9) offers the opportunity to study orbital and sub-orbital scale climate variability under boundary conditions different from those of better studied intervals such as the Holocene and the Last Interglacial. Yet, it is poorly represented in independently-dated continental archives around the Mediterranean Region. Here, we present a speleothem stable isotope record (δ18O and δ13C) from the Former Yugoslavian Republic of Macedonia (F.Y.R.O.M., southern Balkans), which consists of two periods of growth broadly covering the ca. 332 to 292 ka and the ca. 264 to 248 ka intervals (MIS 9e-b and late MIS 8). We interpret the speleothem δ18O as mostly related to regional hydrology, with variations that can be interpreted as due to changes in rainfall amount, with higher/lower values associated to drier/wetter condition. This interpretation is corroborated by a change in mineralogical composition between aragonite and calcite at ca. 328 ka, which marks increasing precipitation at the onset of MIS 9 and occurs within a trend of decreasing δ18O values. Also the comparison with the multiproxy climate record available from the nearby Lake Ohrid seems to support the proposed interpretation. The MIS 9e interglacial appears to be characterized by wettest conditions between ca. 326 and 321 ka, i.e. lasting ca. 5 kyr. Decreasing precipitation and enhanced millennial scale variability matches the glacial inception (MIS9 d to b), with drier events at ca. 319 ka (ca. 2 kyr long) and 310 ka (ca. 1 kyr long), and a major rainfall reduction between 306 and 298 ka. The latter is followed by a prominent wetter period between 298 and 295 ka, for which carbon data values suggest high infiltration rate. Rainfall decreases again after 295 ka, and remain low until the growth interruption at ca. 292 ka. Resumption of the growth and progressive soil development, expressed by the carbon isotope record, occurred during the late part of MIS 8

The MIS 5 palaeoenvironmental record in the SE Mediterranean coast of the Iberian Peninsula (Río Antas, Almería, Spain)

NASA Astrophysics Data System (ADS)

Torres, T.; Ortiz, J. E.; Blázquez, A. M.; Ruiz Zapata, B.; Gil, M. J.; Martín, T.; Sánchez-Palencia, Y.

2015-08-01

Landwards of a MIS5 bar, a borehole core (SRA) was analyzed to establish the relationship between the lagoonal record and the raised beach deposits in the surroundings of the Antas river mouth and to reconstruct the Pleistocene palaeoenvironmental evolution of the southern Mediterranean coast of the Iberian Peninsula. 63 samples were recovered for amino acid racemization dating, 86 samples for sedimentological and paleontological determination, 37 samples for pollen identification and 54 for biomarker analysis. AAR revealed that the borehole record contains MIS11, MIS6 and MIS5 deposits, the latter extensively represented. During the end of MIS6 and MIS5, a sand barrier developed and created a shallow lagoon with alternating terrestrial inputs this process being common in other Mediterranean realms. Litho- and biofacies allowed the identification of distinct paleoenvironments through time, with the presence of a lagoonal environment alternating with alluvial fan progradation. Biomarkers indicated constant input from terrestrial plants, together with variable development of aquatic macrophytes. The palynological content allowed the reconstruction of the paleoclimatological conditions during MIS6 and 5, with evidence of seven scenarios characterized by alternating arid and relatively humid conditions.

Flexible exportation mechanisms of arthrofactin in Pseudomonas sp. MIS38.

PubMed

Lim, S P; Roongsawang, N; Washio, K; Morikawa, M

2009-07-01

To obtain further insights into transportation mechanisms of a most effective biosurfactant, arthrofactin in Pseudomonas sp. MIS38. A cluster genes arfA/B/C encodes an arthrofactin synthetase complex (ArfA/B/C). Downstream of the arfA/B/C lie genes encoding a putative periplasmic protein (ArfD, 362 aa) and a putative ATP-binding cassette transporter (ArfE, 651 aa), namely arfD and arfE, respectively. The arfA/B/C, arfD, and arfE form an operon suggesting their functional connection. Gene knockout mutants ArfD:Km, ArfE:Km, ArfD:Tc/ArfE:Km, and gene overexpression strains MIS38(pME6032_arfD/E) and ArfE:Km(pME6032_arfD/E) were prepared and analysed for arthrofactin production profiles. It was found that the production levels of arthrofactin were temporally reduced in the mutants or increased in the gene overexpression strains, but they eventually became similar level to that of MIS38. Addition of ABC transporter inhibitors, glibenclamide and sodium ortho-vanadate dramatically reduced the production levels of arthrofactin. This excludes a possibility that arthrofactin is exported by diffusion with the aid of its own high surfactant activity. ArfD/E is not an exclusive but a primary exporter of arthrofactin during early growth stage. Reduction in the arthrofactin productivity of arfD and arfE knockout mutants was eventually rescued by another ABC transporter system. Effects of arfD and arfE overexpression were evident only for 1-day cultivation. Multiple ATP dependent active transporter systems are responsible for the production of arthrofactin. Pseudomonas bacteria are characterized to be endued with multiple exporter and efflux systems for secondary metabolites including antibiotics, plant toxins, and biosurfactants. The present work demonstrates exceptionally flexible and highly controlled transportation mechanisms of a most effective lipopeptide biosurfactant, arthrofactin in Pseudomonas sp. MIS38. Because lipopeptide biosurfactants are known to enhance efficacy of

Effect of annealing temperature on the electrical properties of Au/Ta2O5/n-GaN metal-insulator-semiconductor (MIS) structure

NASA Astrophysics Data System (ADS)

Prasanna Lakshmi, B.; Rajagopal Reddy, V.; Janardhanam, V.; Siva Pratap Reddy, M.; Lee, Jung-Hee

2013-11-01

We report on the effect of an annealing temperature on the electrical properties of Au/Ta2O5/n-GaN metal-insulator-semiconductor (MIS) structure by current-voltage ( I- V) and capacitance-voltage ( C- V) measurements. The measured Schottky barrier height ( Φ bo) and ideality factor n values of the as-deposited Au/Ta2O5/n-GaN MIS structure are 0.93 eV ( I- V) and 1.19. The barrier height (BH) increases to 1.03 eV and ideality factor decreases to 1.13 upon annealing at 500 ∘C for 1 min under nitrogen ambient. When the contact is annealed at 600 ∘C, the barrier height decreases and the ideality factor increases to 0.99 eV and 1.15. The barrier heights obtained from the C- V measurements are higher than those obtained from I- V measurements, and this indicates the existence of spatial inhomogeneity at the interface. Cheung’s functions are also used to calculate the barrier height ( Φ bo), ideality factor ( n), and series resistance ( R s ) of the Au/Ta2O5/n-GaN MIS structure. Investigations reveal that the Schottky emission is the dominant mechanism and the Poole-Frenkel emission occurs only in the high voltage region. The energy distribution of interface states is determined from the forward bias I- V characteristics by taking into account the bias dependence of the effective barrier height. It is observed that the density value of interface states for the annealed samples with interfacial layer is lower than that of the density value of interface states of the as-deposited sample.

Phytoplankton assemblages and lipid biomarkers indicate sea-surface warming and sea-ice decline in the Ross Sea during Marine Isotope sub-Stage 5e

NASA Astrophysics Data System (ADS)

Hartman, Julian D.; Sangiorgi, Francesca; Peterse, Francien; Barcena, Maria A.; Albertazzi, Sonia; Asioli, Alessandra; Giglio, Federico; Langone, Leonardo; Tateo, Fabio; Trincardi, Fabio

2016-04-01

The Marine Isotope sub-Stage 5e (~ 125 - 119 kyrs BP), the last interglacial period before the present, is believed to have been globally warmer (~ 2°C) than today. Studying this time interval might therefore provide insights into near future climate state given the ongoing climate change and global temperature increase. Of particular interest are the expected changes in polar ice cover. One important aspect of the cryosphere is sea-ice, which influences albedo, deep and surface water currents, and phytoplankton production, and thus affects the global climate system. To investigate whether changes in sea-ice cover occurred in the Southern Ocean close to Antarctica during Marine Isotope sub-Stage 5e dinoflagellate and diatom assemblages have been analyzed in core AS05-10, drilled in the continental slope off the Drygalski basin (Ross Sea) at a water depth of 2377 m. The core was drilled within the frame of the PNRA 2009/A2.01 project, an Italian project with a multidisciplinary approach, and covers the interval from Present to Marine Isotope Stage (MIS) 7. The core stratigraphy is based on diatom bioevents and on the climate cyclicity provided by the variations of the diatom assemblages. For this study we focused on the interval from MIS7 to MIS5. A strong reduction of sea-ice-loving diatom taxa with respect to open water-loving diatom taxa is observed during MIS5. In general the production of phytoplankton increases at the base of MIS5 and then slowly decreases. Dinoflagellate cysts, particularly heterotrophic species, are abundant during MIS5e only. The sea surface temperature reconstruction based on the TEX86L, a proxy based on lipid biomarkers produced by Thaumarcheota, shows a 4°C temperature increase from MIS6 to MIS5e. A slightly smaller temperature increase is observed at the onset of MIS7, but this stage is barren of heterotrophic dinoflagellates. All proxies together seem to indicate that the retreat of the summer sea-ice in the Ross Sea during MIS5e was

Human choices and environmental constraints: deciphering the variability of large game procurement from Mousterian to Aurignacian times (MIS 5-3) in southwestern France

NASA Astrophysics Data System (ADS)

Discamps, Emmanuel; Jaubert, Jacques; Bachellerie, François

2011-09-01

The evolution in the selection of prey made by past humans, especially the Neandertals and the first anatomically modern humans, has been widely debated. Between Marine Isotope Stages (MIS) 5 and 3, the accuracy of absolute dating is still insufficient to precisely correlate paleoclimatic and archaeological data. It is often difficult, therefore, to estimate to what extent changes in species procurement are correlated with either climate fluctuations or deliberate cultural choices in terms of subsistence behavior. Here, the full development of archeostratigraphy and Bayesian statistical analysis of absolute dates allows the archeological and paleoclimatic chronologies to be compared. The variability in hunted fauna is investigated using multivariate statistical analysis of quantitative faunal lists of 148 assemblages from 39 archeological sequences from MIS 5 through MIS 3. Despite significant intra-technocomplex variability, it is possible to identify major shifts in the human diet during these stages. The integration of archeological data, paleoclimatic proxies and the ecological characteristics of the different species of prey shows that the shifts in large game hunting can be explained by an adaptation of the human groups to climatic fluctuations. However, even if Middle and Early Upper Paleolithic men adapted to changes in their environment and to contrasting landscapes, they ultimately belonged to the ecosystems of the past and were limited by environmental constraints.

Vegetation dynamics of the Guatemalan lowlands from MIS7 to MIS5: Evidence from Lake Petén-Itzá

NASA Astrophysics Data System (ADS)

Cruz-Silva, E.; Correa-Metrio, A.; Bush, M. B.

2013-05-01

Reconstructing vegetation patterns of past warm climatic stages is critical for understanding modern processes that affect diversity and climate. Tropical lowlands are of special interest because of the high biodiversity they foster and the risks they face under a scenario of rapid climate change. With a basal age of more that 191,000 years, core PI-1 from Lake Petén-Itzá, Guatemalan lowlands, offer an exceptional opportunity to investigate the dynamics of the vegetation of the area during climatic stages that might be analogous to today. Pollen analysis of the lower part of this sedimentary record shows a sequence of five different climatic stages of alternating warm and cold conditions. According to our interpretation, tropical forests extended in the area during MIS7 and MIS5, with the former characterized by drier conditions than the latter. Apparently forest dynamics closely followed global climatic changes that were recorded in the Antarctic and the Marine Stack records. Our results confirm that vegetation of the Peninsula, although highly resilient, has been very sensitive to global climatic changes.

Declining MIS Enrollment: The Death of the MIS Degree?

ERIC Educational Resources Information Center

Saunders, Gary; Lockridge, T. Maurice

2011-01-01

There is little doubt that enrollments in MIS degree programs have been declining since the recession in the technical industry in 2001. Reagan's research (2008) indicates that enrollments in MIS degree programs is only about 25% of the 2001 level. Many MIS (IS) programs have been abandoned or combined with other related programs. While many…

New constraints on MIS 7 and 5 relative sea-level at Bermuda: a speleothem approach

NASA Astrophysics Data System (ADS)

Wainer, Karine; Henderson, Gideon; Mason, Andrew; Thomas, Alexander; Williams, Bruce; Rowe, Mark; van Hengstum, Peter; Chandler, Robert

2014-05-01

It is now widely accepted that a sea-level rise is associated with global warming [1]. However, its rate, and the height it might reach by the end of the century remain poorly constrained. This study aims to provide better information and precision on the rates and magnitudes of past sea-level change, for periods when sea-level is close to its modern value, using speleothems from Bermudian caves. Speleothems interrupt their growth when they are submerged by sea-water, so U-Th dating periods of growth in coastal sites allows the reconstruction of past sea-level variation versus absolute time [e.g. 2,3,4]. We will present new MC-ICP-MS U-Th ages, trace elements and isotopic data from a set of speleothems (stalagmites, stalactites, flowstones) collected from -14 to +12 m versus modern sea level from several caves in this northern Atlantic archipelago. Relative sea-level (RSL) at Bermuda is of particular interest because it is at a distance from northern hemisphere ice sheets where the isostatic response to ice-unloading is uncertain. RSL reconstruction therefore provides both an indicates of possible rates of sea level change, and a test for glacial-isostatic-adjustment (GIA) models. We will present new relative sea level data for late MIS7, and the different highstands of MIS5. The RSL at Bermuda for these episodes appears to be higher than present. For MIS5a, this is significantly distinct from what is expected from the eustatic sea level. These results will be considered in the context of previous assessments of eustatic change, and of GIA models. [1] Intergovernmental Panel on Climate Change (2007) Contribution of Working Group I to the Fourth Assessment Report, Cambridge Univ. Press. [2] Harmon et al. (1981) Nature 289, 357-360. [3] Richards et al. (1994) Nature 367, 481-483. [4] Bard (2002) EPSL 196, 135-146.

Life Sciences MIS

NASA Technical Reports Server (NTRS)

Dittman, R. A.; Marks, V.

1983-01-01

Management Information System, MIS, provides Life Sciences Projects Division at Johnson Space Center with automated system for project managment. MIS utilizes Tektronix 4027 color graphics display terminal and form-fillout capability. User interface with MIS data base is through series of forms.

Phytoplankton assemblages and (bio)geochemical proxies indicate enhanced productivity and sea-ice decline in the Ross Sea during Marine Isotope sub-Stage 5e

NASA Astrophysics Data System (ADS)

Hartman, Julian; Sangiorgi, Francesca; Albertazzi, Sonia; Ángeles Bárcena, Mariá; Bijl, Peter; Giglio, Federico; Langone, Leonardo; Peterse, Francien; Tateo, Fabio; Trincardi, Fabio; Asioli, Alessandra

2017-04-01

Sea ice is an important component of the Antarctic cryosphere. It plays an important role in climate (e.g. albedo, gas exchange with the atmosphere), ocean circulation and primary productivity. Although sea ice has been increasing on average around Antarctica as a result of current global climate change, long-term model predictions expect sea ice to decline. To better understand the changes in sea-ice cover and its consequences on the oceanography, biology and geochemistry of the Southern Ocean during on-going and near-future warming it is important to study past periods of global warming, such as the Last Interglacial (LIG, 125-119 ka), also known as Marine Isotope sub-Stage 5e (MIS5e). During MIS5e global temperatures were on average 2°C warmer than present-day, the same temperature set as maximum global warming limit during the recent Paris Agreement (COP21). We investigated changes in sea-ice cover and environmental conditions by means of diatom, palynological, foraminifer and (bio)geochemical data in a sediment core (AS05-10) from the continental slope of the Drygalski Basin, Ross Sea (2377 mbsl) encompassing the MIS5e. The core was collected within the frame of the PNRA 2009/A2.01 project, an Italian project with a multidisciplinary approach, and covers approximately the last 350 kyr according to an age model based on diatom bioevents and cyclostratigraphy. The productivity proxies, e.g., excess barium, magnetic susceptibility and diatom abundances show a strong relation to the glacial-interglacial cycles. The rapid deglaciations preceding MIS5e and MIS7e are characterized by Ice Rafted Debris and the presence of reworked material. Subsequently, each interglacial is characterized by enhanced productivity related to a decrease in annual sea-ice cover. The beginning of each interglacial is also marked by changes in the fossil assemblages and organic geochemical proxies indicative of high nutrient conditions and water column stratification due to fresh water

Extreme drying event in the Dead Sea basin during MIS5 from the ICDP Dead Sea Deep Drill Core

NASA Astrophysics Data System (ADS)

Goldstein, S. L.; Stein, M.; Ben-Avraham, Z.; Agnon, A.; Ariztegui, D.; Brauer, A.; Haug, G. H.; Ito, E.; Kitagawa, H.; Torfstein, A.; Yasuda, Y.; The Icdp-Dsddp Scientific Party

2011-12-01

The ICDP funded Dead Sea Deep Drilling Project (DSDDP) recovered the longest and most complete paleo-environmental record in the Middle East, drilling holes of ~450 and ~350 meters in length in deep (~300 m below the lake level) and shallow sites (~3 mbll) respectively. The Dead Sea expands during the glacials and contracts during interglacials, and the sediments comprise a geological archive of the evolving environmental conditions (e.g. rains, floods, dust-storms, droughts). Dead Sea sediments include inorganic aragonite, allowing for dating by U-series (e.g. Haase-Schramm et al. GCA 2004). The deep site cores were opened and described in June 2011. The cores are composed mainly of alternating intervals of marl (aragonite, gypsum and detritus) during glacials, and salts and marls during interglacials. From this stratigraphy we estimate that the deep site core spans ~200 kyr (to the boundary of MIS 6 and 7). A dramatic discovery is a ~40 cm thick interval of partly rounded pebbles at ~235 m below the lake floor. This is the only clean pebbly unit in the entire core. It appears to be a beach layer, near the deepest part of the Dead Sea, lying above ~35 meters of mainly salt. If it is a beach layer, it implies an almost complete dry-down of the paleo-Dead Sea. The pebble layer lies within the last interglacial interval. Our initial attempt to more precisely estimate the age of the possible dry down shows an intriguing correlation between the salt-mud stratigraphy of the Dead Sea core and the oxygen isotope record of Soreq Cave, whereby excursions to light oxygen in the speleothems correspond to periods of salt deposition. Through this comparison, we estimate that the possible dry down occurred during MIS 5e. The occurrence of ~35 meters of mainly salt along with the pebble layer demonstrates a severe dry interval during MIS 5. This observation has implications for the Middle East today, where the Dead Sea level is dropping as all the countries in the area use the

Comparative Study of the Difference of Perioperative Complication and Radiologic Results: MIS-DLIF (Minimally Invasive Direct Lateral Lumbar Interbody Fusion) Versus MIS-OLIF (Minimally Invasive Oblique Lateral Lumbar Interbody Fusion).

PubMed

Jin, Jie; Ryu, Kyeong-Sik; Hur, Jung-Woo; Seong, Ji-Hoon; Kim, Jin-Sung; Cho, Hyun-Jin

2018-02-01

Retrospective observatory analysis. The purpose of this study was to compare the incidence of perioperative complication, difference of cage location, and sagittal alignment between minimally invasive oblique lateral lumbar interbody fusion (MIS-OLIF) and MIS-direct lateral lumbar interbody fusion (DLIF) in the cases of single-level surgery at L4-L5. MIS-DLIF using tubular retractor has been used for the treatment of lumbar degenerative diseases; however, blunt transpsoas dissection poses a risk of injury to the lumbar plexus. As an alternative, MIS-OLIF uses a window between the prevertebral venous structures and psoas muscle. A total of 43 consecutive patients who underwent MIS-DLIF or MIS-OLIF for various L4/L5 level pathologies between November 2011 and April 2014 by a single surgeon were retrospectively reviewed. A complication classification based on the relation to surgical procedure and effect duration was used. Perioperative complications until 3-month postoperatively were reviewed for the patients. Radiologic results including the cage location and sagittal alignment were also assessed with plain radiography. There were no significant statistical differences in perioperative parameters and early clinical outcome between 2 groups. Overall, there were 13 (59.1%) approach-related complications in the DLIF group and 3 (14.3%) in the OLIF group. In the DLIF group, 3 (45.6%) were classified as persistent, however, there was no persistent complication in the OLIF group. In the OLIF group, cage is located mostly in the middle 1/3 of vertebral body, significantly increasing posterior disk space height and foraminal height compared with the DLIF group. Global and segmental lumbar lordosis was greater in the DLIF group due to anterior cage position without statistical significance. In our report of L4/L5 level diseases, the OLIF technique may decrease approach-related perioperative morbidities by eliminating the risk of unwanted muscle and nerve manipulations. Using

MIS-11 duration key to disappearance of the Greenland ice sheet

PubMed Central

Robinson, Alexander; Alvarez-Solas, Jorge; Calov, Reinhard; Ganopolski, Andrey; Montoya, Marisa

2017-01-01

Palaeo data suggest that Greenland must have been largely ice free during Marine Isotope Stage 11 (MIS-11). However, regional summer insolation anomalies were modest during this time compared to MIS-5e, when the Greenland ice sheet likely lost less volume. Thus it remains unclear how such conditions led to an almost complete disappearance of the ice sheet. Here we use transient climate–ice sheet simulations to simultaneously constrain estimates of regional temperature anomalies and Greenland’s contribution to the MIS-11 sea-level highstand. We find that Greenland contributed 6.1 m (3.9–7.0 m, 95% credible interval) to sea level, ∼7 kyr after the peak in regional summer temperature anomalies of 2.8 °C (2.1–3.4 °C). The moderate warming produced a mean rate of mass loss in sea-level equivalent of only around 0.4 m per kyr, which means the long duration of MIS-11 interglacial conditions around Greenland was a necessary condition for the ice sheet to disappear almost completely. PMID:28681860

MIS-11 duration key to disappearance of the Greenland ice sheet

NASA Astrophysics Data System (ADS)

Robinson, Alexander; Alvarez-Solas, Jorge; Calov, Reinhard; Ganopolski, Andrey; Montoya, Marisa

2017-07-01

Palaeo data suggest that Greenland must have been largely ice free during Marine Isotope Stage 11 (MIS-11). However, regional summer insolation anomalies were modest during this time compared to MIS-5e, when the Greenland ice sheet likely lost less volume. Thus it remains unclear how such conditions led to an almost complete disappearance of the ice sheet. Here we use transient climate-ice sheet simulations to simultaneously constrain estimates of regional temperature anomalies and Greenland's contribution to the MIS-11 sea-level highstand. We find that Greenland contributed 6.1 m (3.9-7.0 m, 95% credible interval) to sea level, ~7 kyr after the peak in regional summer temperature anomalies of 2.8 °C (2.1-3.4 °C). The moderate warming produced a mean rate of mass loss in sea-level equivalent of only around 0.4 m per kyr, which means the long duration of MIS-11 interglacial conditions around Greenland was a necessary condition for the ice sheet to disappear almost completely.

MIS-11 duration key to disappearance of the Greenland ice sheet.

PubMed

Robinson, Alexander; Alvarez-Solas, Jorge; Calov, Reinhard; Ganopolski, Andrey; Montoya, Marisa

2017-07-06

Palaeo data suggest that Greenland must have been largely ice free during Marine Isotope Stage 11 (MIS-11). However, regional summer insolation anomalies were modest during this time compared to MIS-5e, when the Greenland ice sheet likely lost less volume. Thus it remains unclear how such conditions led to an almost complete disappearance of the ice sheet. Here we use transient climate-ice sheet simulations to simultaneously constrain estimates of regional temperature anomalies and Greenland's contribution to the MIS-11 sea-level highstand. We find that Greenland contributed 6.1 m (3.9-7.0 m, 95% credible interval) to sea level, ∼7 kyr after the peak in regional summer temperature anomalies of 2.8 °C (2.1-3.4 °C). The moderate warming produced a mean rate of mass loss in sea-level equivalent of only around 0.4 m per kyr, which means the long duration of MIS-11 interglacial conditions around Greenland was a necessary condition for the ice sheet to disappear almost completely.

Depositional and sea-level history from MIS 6 (Termination II) to MIS 3 on the southern continental shelf of South Africa

NASA Astrophysics Data System (ADS)

Cawthra, H. C.; Jacobs, Z.; Compton, J. S.; Fisher, E. C.; Karkanas, P.; Marean, C. W.

2018-02-01

Pleistocene shoreline deposits comprised of calcified shallow marine (palaeobeach) and aeolian (palaeodune) facies found along mid-latitude coastlines can be useful indicators of past sea levels. Here, we describe a succession of such deposits that are presently exposed both above (subaerial) and below (submerged) mean sea level along the southern Cape coast of South Africa, 18 km east of the town of Mossel Bay. The submerged units provide a window on Late Pleistocene coastal processes, as palaeoshoreline deposits in this study extend to water depths of up to 55 m on the mid-shelf. Five sedimentary facies were identified in the strata and were compared to modern depositional environments of the local littoral zone, which include aeolian dune, upper shoreface, foreshore, intertidal swash and back-barrier settings. Twenty-two geological units were observed and mapped. Some of these units were directly dated with optically stimulated luminescence (OSL) dating. OSL ages were obtained for ten samples from the subaerial and twelve samples from the submerged deposits. Those geological units not directly dated were interpreted based on sedimentology and field/stratigraphic relationships to dated units. The stratigraphy and chronology of the succession indicates a record of initial deposition during Termination II (T-II) meltwater events, preceding and leading to marine isotope stage (MIS) 5e. Indicators for multiple sea-level fluctuations between MIS 5d and MIS 4, and sediment deposition at the end of MIS 4 and start of MIS 3 are also found. Both regressive and transgressive depositional cycles are well-preserved in the succession. We propose that palaeodune and palaeobeach deposits along the South Coast of South Africa have no clear preference for deposition during sea-level transgressions or regressions. Sediment deposition more closely mirrors the rate of sea level change, with deposition and preservation either during times of rapid sea-level movement, or oscillation

Integrated geochronology of Acheulian sites from the southern Latium (central Italy): Insights on human-environment interaction and the technological innovations during the MIS 11-MIS 10 period

NASA Astrophysics Data System (ADS)

Pereira, Alison; Nomade, Sébastien; Moncel, Marie-Hélène; Voinchet, Pierre; Bahain, Jean-Jacques; Biddittu, Italo; Falguères, Christophe; Giaccio, Biagio; Manzi, Giorgio; Parenti, Fabio; Scardia, Giancarlo; Scao, Vincent; Sottili, Gianluca; Vietti, Amina

2018-05-01

We have explored the multimethod approach combining 40Ar/39Ar on single crystal, ESR on bleached quartz, and ESR/U-series on teeth to improve the age of four neighbours "Acheulian" sites of the Frosinone Province (Latium, Italy): Fontana Ranuccio, Cava Pompi (Pofi), Isoletta, and Lademagne. Ages obtained by the three methods are in mutual agreement and confirm the potential of dating with confidence Middle Pleistocene sites of Italy using these methods. At Fontana Ranuccio, the 40Ar/39Ar age (408 ± 10 ka, full external error at 2σ) obtained for the archaeological level (unit FR4) and geochemical analyses of glass shards performed on the Unit FR2a layer allow us to attribute the studied volcanic material to the Pozzolane Nere volcanic series, a well-known caldera-forming event originated from the Colli Albani volcanic district. These new data ascribe the Fontana Ranuccio site, as well as the eponym faunal unit, to the climatic optimum of Marine Isotope Stage (MIS) 11. Ages obtained for the Cava Pompi, Isoletta, and Lademagne sites cover a relatively short period of time between 408 ka and 375 ka, spanning MIS 11 climatic optimum to the MIS 11-10 transition. Analysis of small collections of lithic industries, bifacial tools, and small cores technologies from Isoletta, Lademagne, and the neighbour site of Ceprano-Campogrande shows common technical strategies for the period comprised between MIS 11 and MIS 9 (410-325 ka), such as the elaboration of flaked elephant bone industries found over the whole Latium region. However, some features found only in the Frosinone province area, like large-sized bifaces, suggest particular regional behaviours. The presence of one Levallois core in the oldest layer of Lademagne (i.e. > 405 ± 9 ka) suggests a punctual practice of this technology, also proposed as early as MIS 10/11 in the neighbour site of Guado San Nicola (Molise) in central Italy.

When Less Is More: The indications for MIS Techniques and Separation Surgery in Metastatic Spine Disease.

PubMed

Zuckerman, Scott L; Laufer, Ilya; Sahgal, Arjun; Yamada, Yoshiya J; Schmidt, Meic H; Chou, Dean; Shin, John H; Kumar, Naresh; Sciubba, Daniel M

2016-10-15

Systematic review. The aim of this study was to review the techniques, indications, and outcomes of minimally invasive surgery (MIS) and separation surgery with subsequent radiosurgery in the treatment of patients with metastatic spine disease. The utilization of MIS techniques in patients with spine metastases is a growing area within spinal oncology. Separation surgery represents a novel paradigm where radiosurgery provides long-term control after tumor is surgically separated from the neural elements. PubMed, Embase, and CINAHL databases were systematically queried for literature reporting MIS techniques or separation surgery in patients with metastatic spine disease. PRISMA guidelines were followed. Of the initial 983 articles found, 29 met inclusion criteria. Twenty-five articles discussed MIS techniques and were grouped according to the primary objective: percutaneous stabilization (8), tubular retractors (4), mini-open approach (8), and thoracoscopy/endoscopy (5). The remaining 4 studies reported separation surgery. Indications were similar across all studies and included patients with instability, refractory pain, or neurologic compromise. Intraoperative variables, outcomes, and complications were similar in MIS studies compared to traditional approaches, and some MIS studies showed a statistically significant improvement in outcomes. Studies of mini-open techniques had the strongest evidence for superiority. Low-quality evidence currently exists for MIS techniques and separation surgery in the treatment of metastatic spine disease. Given the early promising results, the next iteration of research should include higher-quality studies with sufficient power, and will be able to provide higher-level evidence on the outcomes of MIS approaches and separation surgery. N/A.

Genesis, evolution, and catastrophic burying of the Ryshkovo paleosol of the Mikulino Interglacial (MIS 5e)

NASA Astrophysics Data System (ADS)

Sycheva, S. A.; Sedov, S. N.; Bronnikova, M. A.; Targulian, V. O.; Solleiro-Rebolledo, E.

2017-09-01

The results of a hierarchical morphogenetic, physicochemical, and mineralogical study of the Ryshkovo full-profile texture-differentiated paleosol of the Mikulino Interglacial from the section at Aleksandrov quarry in Kursk oblast are discussed. The correlation analysis of the stratigraphy of this section with global geological records made it possible to determine the position of the Ryshkovo paleosol in the chronostratigraphic system of the Late Pleistocene and to attribute it to stage MIS 5e; the duration of pedogenesis for this paleosol was no more than 12-15 ka. The results of the study indicate that the Ryshkovo paleosol is close in its properties to the Holocene soddy-podzolic soils of the East European Plain. No direct evidences in favor of the former interpretation of this paleosol as a lessivated soil genetically close to Luvisols of nemoral broadleaved forest of Central Europe have been found. The difference between the paleosol of the Mikulino Interglacial and the modern soddy-podzolic soils is mainly related to the distribution of clay coatings. In the upper part of the illuvial horizon of Mikulino paleosol, clay coatings are few in number, and typical tongues of podzolized (albic) material are absent in the profile. At the same time, silty coatings (skeletans) are abundant even in the lower part of the illuvial horizon. In general, the Mikulino paleosol is characterized by a smaller diversity of clay pedofeatures. These differences might be related to less contrasting fluctuations of the environmental conditions in the second half of the Mikulino Interglacial, to the periodical renewal of the eluvial part of Mikulino paleosol by erosional and accumulative processes, and to the absence of anthropogenic impacts on the soil during the Mikulino Interglacial. The burying of the Ryshkovo paleosol took place due to the intense development of erosional processes induced by the contrasting climatic events at the end of the interglacial period accompanied by

Insights into North Atlantic deep water formation during the peak interglacial interval of Marine Isotope Stage 9 (MIS 9)

NASA Astrophysics Data System (ADS)

Mokeddem, Zohra; McManus, Jerry F.

2017-11-01

Foraminifera abundance and stable isotope records from ODP Site 984 (61.25°N, 24.04°W, 1648 m) in the North Atlantic are used to reconstruct surface circulation variations and the relative strength of the North Atlantic Deep Water (NADW) formation over the period spanning the peak warmth of Marine Interglacial Stage (MIS) 9e ( 324-336 ka). This interval includes the preceding deglaciation, Termination 4 (T4), and the subsequent glacial inception of MIS 9d. The records indicate a greatly reduced contribution of NADW during T4, as observed in more recent deglaciations. In contrast with the most recent deglaciation, the lack of a significant NADW signal extended from T4 well into the peak interglacial MIS 9e and persisted nearly until the transition to the subsequent glacial stage MIS 9d. Although NADW formation resumed during MIS 9e, only depths greater than 2000 m appear to have been ventilated. The poorly ventilated intermediate depth of Site 984 (<2000 m) may have resulted on one hand from a general reduction of deep water ventilation by NADW during the study interval or, on the other hand, from different pathways of the spread of newly formed NADW that bypassed the study location. The intermediate depths may have also been invaded by southern-sourced waters as the formation of intermediate depth NADW weakened. The absence of any significant NADW signal at the water depth of Site 984 during the climatic optimum contrasts sharply with subsequent interglacial peaks (MIS 5e and the Holocene). Despite the perturbed intermediate depth circulation, oceanic heat transport northeastward was not interrupted and may have contributed to the relatively mild interglacial conditions of MIS 9e.

Investigating annually-resovled natural climate variability during MIS 11 using lacustrine records

NASA Astrophysics Data System (ADS)

Tye, G. J.; Palmer, A. P.; Candy, I.; Coxon, P.; Hardiman, M.

2012-04-01

Marine isotope stage 11 (MIS 11, ca 410,000 yrs BP) is considered to be one of the best analogues for current and future climate change due to the similarity of orbital forcing patterns during these two interglacials. Marine and ice-core records suggest that MIS 11 was a particularly long interglacial, characterised by stable climates. The investigation of high-resolution climate records from MIS 11 can, therefore, allow us to understand how the climate of a Holocene-like interglacial might evolve in the absence of anthropogenic modification. MIS 11 sediments preserved in the palaeolake basin at Marks Tey, eastern England, offer the potential for such a study as they are considered to be annually-laminated (varved) throughout a large part of the interglacial (Turner, 1970, 1975). The lamination sets appear to be comprised, primarily, of three regularly occurring laminae types; 1) authigenic carbonate, 2) diatom blooms, and 3) organic detritus, although there appears to be some variability in the microfacies of these laminations. The carbonate laminations are the key to the study of climate variability during MIS 11, as they represent authigenic carbonate precipitation, consistent with temperature/biologically driven changes in lake chemistry during the summer months. Oxygen isotopic analysis of the carbonate therefore gives a proxy for summer temperature. A period of key interest in the MIS 11 sequence at Marks Tey occurs during the early part of the interglacial, where there is a short-lived increase in grass pollen relative to tree pollen, termed the Non-Arboreal Pollen Zone (NAPZ). The cause of this shift in pollen has been subject to debate, with natural wildfire (Turner, 1970) or climatic deterioration (e.g. Kelly, 1964) being suggested as possible forcing mechanisms. In this study, as well as discussing the main characteristics of the MIS 11 sequence at Marks Tey, we will focus on the sedimentary, micromorphological and geochemical record of the NAPZ. In

Improved insulator layer for MIS devices

NASA Technical Reports Server (NTRS)

Miller, W. E.

1980-01-01

Insulating layer of supersonic conductor such as LaF sub 3 has been shown able to impart improved electrical properties to photoconductive detectors and promises to improve other metal/insulator/semiconductor (MIS) devices, e.g., MOSFET and integrated circuits.

The chronostratigraphy of the Haua Fteah cave (Cyrenaica, northeast Libya) - Optical dating of early human occupation during Marine Isotope Stages 4, 5 and 6.

PubMed

Jacobs, Zenobia; Li, Bo; Farr, Lucy; Hill, Evan; Hunt, Chris; Jones, Sacha; Rabett, Ryan; Reynolds, Tim; Roberts, Richard G; Simpson, David; Barker, Graeme

2017-04-01

The paper presents the results of optical dating of potassium-rich feldspar grains obtained from the Haua Fteah cave in Cyrenaica, northeast Libya, focussing on the chronology of the Deep Sounding excavated by Charles McBurney in the 1950s and re-excavated recently. Samples were also collected from a 1.25 m-deep trench (Trench S) excavated during the present project below the basal level of the Deep Sounding. Optically stimulated luminescence (OSL) data sets for multi-grain, single aliquots of quartz for samples from the Middle Trench were previously published. Re-analyses of these OSL data confirm significant variation in the dose saturation levels of the quartz signal, but allow the most robust OSL ages to be determined for comparison with previous age estimates and with those obtained in this study for potassium-rich feldspars from the Deep Sounding. The latter indicate that humans may have started to visit the cave as early as ∼150 ka ago, but that major use of the cave occurred during MIS 5, with the accumulation of the Deep Sounding sediments. Correlations between optical ages and episodes of "Pre-Aurignacian" artefact discard indicate that human use of the cave during MIS 5 was highly intermittent. The earliest phases of human activity appear to have occurred during interstadial conditions (5e and 5c), with a later phase of lithic discard associated with more stadial conditions, possibly MIS 5b. We argue that the "Pre-Aurignacian" assemblage can probably be linked with modern humans, like the succeeding "Levalloiso-Mousterian" assemblage; two modern human mandibles associated with the latter are associated with a modelled age of 73-65 ka. If this attribution is correct, then the new chronology implies that modern humans using "Pre-Aurignacian" technologies were in Cyrenaica as early as modern humans equipped with "Aterian" technologies were in the Maghreb, raising new questions about variability among lithic technologies during the initial phases of

MIS On-Line.

ERIC Educational Resources Information Center

Thomson, Nancy S.; Echeverria, Donna Rose; Mills, Bob

This paper describes the resources, processes and outcomes involved in the development of an introductory Management Information Systems (MIS) course designed to utilize as many of the technologies as possible to redefine the teaching/learning paradigm. The MIS-Online project at Northwest Missouri State University encompasses the available campus…

Investigation of the sensitivity of MIS-sensor to thermal decomposition products of cables insulation

NASA Astrophysics Data System (ADS)

Filipchuk, D. V.; Litvinov, A. V.; Etrekova, M. O.; Nozdrya, D. A.

2017-12-01

Sensitivity of the MIS-sensor to products of thermal decomposition of insulation and jacket of the most common types of cables is investigated. It is shown that hydrogen is evolved under heating the insulation to temperatures not exceeding 250 °C. Registration of the evolved hydrogen by the MIS-sensor can be used for detection of fires at an early stage.

ProMIS augmented reality training of laparoscopic procedures face validity.

PubMed

Botden, Sanne M B I; Buzink, Sonja N; Schijven, Marlies P; Jakimowicz, Jack J

2008-01-01

Conventional video trainers lack the ability to assess the trainee objectively, but offer modalities that are often missing in virtual reality simulation, such as realistic haptic feedback. The ProMIS augmented reality laparoscopic simulator retains the benefit of a traditional box trainer, by using original laparoscopic instruments and tactile tasks, but additionally generates objective measures of performance. Fifty-five participants performed a "basic skills" and "suturing and knot-tying" task on ProMIS, after which they filled out a questionnaire regarding realism, haptics, and didactic value of the simulator, on a 5-point-Likert scale. The participants were allotted to 2 experience groups: "experienced" (>50 procedures and >5 sutures; N = 27), and "moderately experienced" (<50 procedures and <5 sutures; N = 28). General consensus among all participants, particularly the experienced, was that ProMIS is a useful tool for training (mean: 4.67, SD: 0.48). It was considered very realistic (mean: 4.44, SD: 0.66), with good haptics (mean: 4.10, SD: 0.97) and didactic value (mean 4.10, SD: 0.65). This study established the face validity of the ProMIS augmented reality simulator for "basic skills" and "suturing and knot-tying" tasks. ProMIS was considered a good tool for training in laparoscopic skills for surgical residents and surgeons.

The Valle di Manche section (Calabria, Southern Italy): A high resolution record of the Early-Middle Pleistocene transition (MIS 21-MIS 19) in the Central Mediterranean

NASA Astrophysics Data System (ADS)

Capraro, Luca; Ferretti, Patrizia; Macrì, Patrizia; Scarponi, Daniele; Tateo, Fabio; Fornaciari, Eliana; Bellini, Giulia; Dalan, Giorgia

2017-06-01

The on-land marine Valle di Manche section (Crotone Basin, Calabria, Southern Italy), one of the candidates to host the GSSP of the Middle Pleistocene (;Ionian;) Stage, preserves a manifold record of independent chronological, paleoclimatic and stratigraphic proxies that permit a straightforward correlation with marine and terrestrial reference records at the global scale. In particular, the section holds an excellent record of the Matuyama-Brunhes magnetic reversal, which occurs in the midst of Marine Isotope Stage (MIS) 19. We report on a complete revision of the section that improves dramatically the available dataset, especially in the stratigraphic interval straddling the Lower-Middle Pleistocene boundary. Our benthic δ18O record provides evidence that the Matuyama-Brunhes transition, the stratigraphic position of which is marked by a prominent tephra (the ;Pitagora ash;), occurred during full MIS 19, in agreement with many records worldwide. We obtained an age of 786.9 ± 5 ka for the Matuyama-Brunhes magnetic reversal and pinpointed the paleomagnetic transition of to a 3 cm-thick interval, indicating that the event was very fast. Since the section fulfills all the requirements to host the GSSP of the Ionian Stage, we propose that the boundary should be placed at the base of the ;Pitagora ash;, ca. 12.5 cm below the midpoint of the Matuyama-Brunhes reversal.

Climate changes in south western Iberia and Mediterranean Outflow variations during two contrasting cycles of the last 1 Myrs: MIS 31-MIS 30 and MIS 12-MIS 11

NASA Astrophysics Data System (ADS)

Sánchez Goñi, M. F.; Llave, E.; Oliveira, D.; Naughton, F.; Desprat, S.; Ducassou, E.; Hodell, D. A.; Hernández-Molina, F. J.

2016-01-01

Grain size analysis and physical properties of Sites U1388, U1389 and U1390 collected in the Contourite Depositional System of the Gulf of Cádiz during the Integrated Ocean Drilling Program (IODP) Expedition 339 "Mediterranean Outflow" reveal relative changes in bottom current strength, a tracer of the dynamics of the Mediterranean Outflow Water (MOW), before and after the Middle Pleistocene Transition (MPT). The comparison of MOW behavior with climate changes identified by the pollen analysis and δ18O benthic foraminifera measurements of Site U1385, the Shackleton Site, collected in the south western Iberian margin shows that the interval MIS 31-MIS 30, ~ 1.1-1.05 million years ago (Ma), before the MPT, was marked by wetter climate and weaker bottom current than the interval MIS 12-MIS 11 (0.47-0.39 Ma), after the MPT. Similarly, the increase in fine particles from these glacials to interglacials and in coarse fraction from interglacials to glacials was coeval with forest and semi-desert expansions, respectively, indicating the lowering/enhancement of MOW strength during periods of regional increase/decrease of moisture. While these findings may not necessarily apply to all glacial/interglacial cycles, they nonetheless serve as excellent supporting examples of the hypothesis that aridification can serve as a good tracer for MOW intensity. The strongest regional aridity during MIS 12 coincides with a remarkable increase of coarse grain size deposition and distribution that we interpret as a maximum in MOW strength. This MOW intensification may have pre-conditioned the North Atlantic by increasing salinity, thereby triggering the strong resumption of the Meridional Overturning Circulation that could contribute to the great warmth that characterizes the MIS 11c super-interglacial.

A rhinocerotid-dominated megafauna at the MIS6-5 transition: The late Middle Pleistocene Coc Muoi assemblage, Lang Son province, Vietnam

NASA Astrophysics Data System (ADS)

Bacon, Anne-Marie; Antoine, Pierre-Olivier; Huong, Nguyen Thi Mai; Westaway, Kira; Tuan, Nguyen Anh; Duringer, Philippe; Zhao, Jian-xin; Ponche, Jean-Luc; Dung, Sam Canh; Nghia, Truong Huu; Minh, Tran Thi; Son, Pham Thanh; Boyon, Marc; Thuy, Nguyen Thi Kim; Blin, Amandine; Demeter, Fabrice

2018-04-01

Little is known about the ecosystems in the north of the Indochinese peninsula at the Middle-Late Pleistocene transition. In this paper, we analyzed the new fauna from Coc Muoi cave, Lang Son province, northeast Vietnam. In comparison with other well-documented faunas from the region, that of Coc Muoi is distinguished by the predominance of rhinoceroses among diverse large-bodied herbivores. The results of the OSL and pIR-IRSL dating of the cave sediments and U-series dating of flowstones indicate a potential age range of 148-117 ka for the fauna (MIS6-5). The analysis of age-at-death distributions of rhinoceroses, wild cattle, sambar deer, and wild pig, does not show any apparent selectivity of age classes. We also focused our study on rhinoceroses, tapirs, and wild cattle by analyzing the prevalence of hypoplastic defects on deciduous and permanent teeth, in an attempt to assess the health status of the taxa during their first years of growth. The health status of large-bodied herbivores (kouprey and rhinoceros) reveals the importance of stressors (biotic and abiotic) in the rainforest environment during a period of marked climatic transition (MIS6-5) in comparison with other MIS5-4 well-documented faunas from the region.

Differentiation of MIS 9 and MIS 11 in the continental record: vegetational, faunal, aminostratigraphic and sea-level evidence from coastal sites in Essex, UK

NASA Astrophysics Data System (ADS)

Roe, Helen M.; Coope, G. Russell; Devoy, Robert J. N.; Harrison, Colin J. O.; Penkman, Kirsty E. H.; Preece, Richard C.; Schreve, Danielle C.

2009-11-01

to have formed during the Ipswichian (MIS 5e). This evidence is compared with other important sites of late Middle Pleistocene age in Britain and elsewhere on the continent and the importance of a multidisciplinary approach is stressed.

Differentiation of MIS 9 and MIS 11 in the continental record: vegetational, faunal, aminostratigraphic and sea-level evidence from coastal sites in Essex, UK

PubMed Central

Roe, Helen M.; Coope, G. Russell; Devoy, Robert J.N.; Harrison, Colin J.O.; Penkman, Kirsty E.H.; Preece, Richard C.; Schreve, Danielle C.

2009-01-01

to have formed during the Ipswichian (MIS 5e). This evidence is compared with other important sites of late Middle Pleistocene age in Britain and elsewhere on the continent and the importance of a multidisciplinary approach is stressed. PMID:20119485

MIS Score: Prediction Model for Minimally Invasive Surgery.

PubMed

Hu, Yuanyuan; Cao, Jingwei; Hou, Xianzeng; Liu, Guangcun

2017-03-01

Reports suggest that patients with spontaneous intracerebral hemorrhage (ICH) can benefit from minimally invasive surgery, but the inclusion criterion for operation is controversial. This article analyzes factors affecting the 30-day prognoses of patients who have received minimally invasive surgery and proposes a simple grading scale that represents clinical operation effectiveness. The records of 101 patients with spontaneous ICH presenting to Qianfoshan Hospital were reviewed. Factors affecting their 30-day prognosis were identified by logistic regression. A clinical grading scale, the MIS score, was developed by weighting the independent predictors based on these factors. Univariate analysis revealed that the factors that affect 30-day prognosis include Glasgow coma scale score (P < 0.01), age ≥80 years (P < 0.05), blood glucose (P < 0.01), ICH volume (P < 0.01), operation time (P < 0.05), and presence of intraventricular hemorrhage (P < 0.001). Logistic regression revealed that the factors that affect 30-day prognosis include Glasgow coma scale score (P < 0.05), age (P < 0.05), ICH volume (P < 0.01), and presence of intraventricular hemorrhage (P < 0.05). The MIS score was developed accordingly; 39 patients with 0-1 MIS scores had favorable prognoses, whereas only 9 patients with 2-5 MIS scores had poor prognoses. The MIS score is a simple grading scale that can be used to select patients who are suited for minimal invasive drainage surgery. When MIS score is 0-1, minimal invasive surgery is strongly recommended for patients with spontaneous cerebral hemorrhage. The scale merits further prospective studies to fully determine its efficacy. Copyright © 2016 Elsevier Inc. All rights reserved.

Human occupation of the Arabian Empty Quarter during MIS 5: evidence from Mundafan Al-Buhayrah, Saudi Arabia

NASA Astrophysics Data System (ADS)

Groucutt, Huw S.; White, Tom S.; Clark-Balzan, Laine; Parton, Ash; Crassard, Rémy; Shipton, Ceri; Jennings, Richard P.; Parker, Adrian G.; Breeze, Paul S.; Scerri, Eleanor M. L.; Alsharekh, Abdullah; Petraglia, Michael D.

2015-07-01

The Empty Quarter (or Rub' al Khali) of the Arabian Peninsula is the largest continuous sandy desert in the world. It has been known for several decades that Late Pleistocene and Holocene deposits, representing phases of wetter climate, are preserved there. These sequences have yielded palaeontological evidence in the form of a variety of vertebrate and invertebrate fossils and have been dated using various radiometric techniques. However, evidence for human presence during these wetter phases has until now been ephemeral. Here, we report on the first stratified and dated archaeology from the Empty Quarter, recovered from the site of Mundafan Al-Buhayrah (MDF-61). Human occupation at the site, represented by stone tools, has been dated to the later part of Marine Isotope Stage (MIS) 5 using multiple luminescence dating techniques (multigrain and single grain OSL, TT-OSL). The sequence consists primarily of lacustrine and palustrine sediments, from which evidence for changing local environmental conditions has been obtained through analysis of fossil assemblages (phytoliths and non-marine molluscs and ostracods). The discovery of securely-dated archaeological material at ∼100 to 80 ka in the Empty Quarter has important implications for hypotheses concerning the timing and routes of dispersal of Homo sapiens out of Africa, which have been much debated. Consequently, the data presented here fill a crucial gap in palaeoenvironmental and archaeological understanding of the southern Arabian interior. Fossils of H. sapiens in the Levant, also dated to MIS 5, together with Middle Palaeolithic archaeological sites in Arabia and India are thought to represent the earliest dispersal of our species out of Africa. We suggest that the widespread occurrence of similar lithic technologies across southern Asia, coupled with a growing body of evidence for environmental amelioration across the Saharo-Arabian belt, indicates that occupation of the Levant by H. sapiens during MIS 5

A Methodology for Successful MIS Projects

PubMed Central

Jacobs, Patt

1988-01-01

St. Vincent Hospital and Medical Center (SVHMC) was one of the Pacific Northwests' first hospitals to install a Medical Information System (MIS). In mid 1985 the hospital was confronted with the fact that vendor support of its MIS would be withdrawn in the near future. In 21 months a complete, fully operational MIS had to be selected, installed, and implemented. MIS projects are large, complicated sets of interrelated tasks organized to achieve a specific goal for an organization. Project management requires a sound methodology to deliver proper and necessary functions, on time, within budget, and that meet user expectations. This paper focuses on the process used to deliver the SIMON System on time and 15% under budget.

Sea level high stand in Marine Isotope Stage 5e: evidence from coral terraces in Sumba Island, Indonesia

NASA Astrophysics Data System (ADS)

LU, Y.; Rigaud, S.; Leclerc, F.; Liu, X.; Chiang, H. W.; Djamil, Y. S.; Meilano, I.; Bijaksana, S.; Abidin, H. Z.; Tapponnier, P.; Wang, X.

2017-12-01

Uplifted coral reef terraces, possibly spanning the last one million years, are extensively exposed along the northern coast of Sumba Island, Indonesia. We collected a suite of fossil coral samples from the inner edges of terraces at Cape Laundi to study past sea level change, particularly that during the marine isotope stage 5e. These samples were dated by the high-precision U/Th disequilibrium dating methods. For those with δ234U-initial values beyond the range of 145±7‰[1,2] , the open-system model by Thompson et al. [3] was then applied to correct their ages. Only less than 20% of the samples could not derive reasonable ages after the correction, and their abnormally high δ234U-initial values (> 180‰) seem to suggest a limitation of open-system correction with the current model. After the correction of long-term uplift rate of 0.3 mm/kyr, we found that the relative sea level at Cape Laundi, Sumba was 7 m during MIS5e and then dropped to -20 m during the MIS5a and 5c. More importantly, our results indicate that sea level reached a high stand at 129±0.6 ka, supported by both U/Th dates on pristine corals and open-system model corrected ages. In line with the sea level reconstruction from western Australia, our results do not support a second and higher sea level during MIS5e. Moreover, there is no significant lead or lag between the timing of sea level high stand in Sumba and the peak of Northern Hemisphere summer insolation. 1. Robinson et al. (2004) Science. 305: 851-854 2. Cheng et al. (2013) Earth and Planetary Science Letters. 371-372: 82-91 3. Thompson et al. (2003) Earth and Planetary Science Letters. 210: 365-381

Climatic variability during the penultimate interglacial (MIS 7) and glacial (MIS 6) periods recorded in a speleothem from Kanaan cave, Lebanon (Central Levant)

NASA Astrophysics Data System (ADS)

Nehme, Carole; Verheyden, Sophie; Breitenbach, Sebastian F. M.; Gillikin, David P.; Verheyden, Anouk; Cheng, Hai; Edwards, Laurence; Hellstrom, John; Noble, Stephen R.; Farrant, Andrew R.; Sahy, Diana; Goovaerts, Thomas; Salem, Ghada; Claeys, Philippe

2017-04-01

Little is known about terrestrial climate dynamics of the Levant during the penultimate interglacial-glacial period. A well-dated stalagmite ( 194 to 154 ka) from Kanaan cave, located near the Mediterranean in Lebanon, is examined for its petrography, growth history, and stable isotope geochemistry to answer the climate instability pattern of the glacial MIS 6 and possible wet phases. A highly resolved continental climate record from the northern Levant has been recovered from this precisely U-Th-dated speleothem, spanning the late penultimate interglacial (equivalent of the MIS 7) to the mid-penultimate glacial period ( MIS 6). The stalagmite grew slowly and discontinuously with an unstable isotopic pattern from 194 and at least up to 178 ka. Subsequently, the stalagmite ceased growing from 169.5 to 163.1 ka (interpolated ages) with a hiatus of ca. 6.24 ka according to the model age. However, low δ 18O and δ 13C values indicate generally cold, but overall more humid climate compared to the last glacial (MIS 3). Higher growth rates during the mid-penultimate glacial period ( 163-154 ka) are most probably linked to increased water recharge in the vadose zone. A short More distinct layering in the upper section compared to the basal part of the stalagmite suggests stronger seasonality from 163 ka to 154 ka. Negative oxygen and carbon isotope excursions were found at ˜155.5 ka, ˜156 ka, between ˜159.6 and ˜160.1 ka and at ˜162.6 ka. The inferred Kanaan cave humid intervals during the mid-penultimate period follow variations of pollen records in the Eastern and Western Mediterranean basins and correlate well with the synthetic Greenland records and East Asian Summer Monsoon Interstadials, indicating short warm/wet periods similar to the D-O events during MIS 4-3 in the Eastern Mediterranean region.

A high-resolution mid-Pleistocene temperature record from Arctic Lake El'gygytgyn: a 50 kyr super interglacial from MIS 33 to MIS 31?

NASA Astrophysics Data System (ADS)

de Wet, Gregory A.; Castañeda, Isla S.; DeConto, Robert M.; Brigham-Grette, Julie

2016-02-01

Previous periods of extreme warmth in Earth's history are of great interest in light of current and predicted anthropogenic warming. Numerous so called "super interglacial" intervals, with summer temperatures significantly warmer than today, have been identified in the 3.6 million year (Ma) sediment record from Lake El'gygytgyn, northeast Russia. To date, however, a high-resolution paleotemperature reconstruction from any of these super interglacials is lacking. Here we present a paleotemperature reconstruction based on branched glycerol dialkyl glycerol tetraethers (brGDGTs) from Marine Isotope Stages (MIS) 35 to MIS 29, including super interglacial MIS 31. To investigate this period in detail, samples were analyzed with an unprecedented average sample resolution of 500 yrs from MIS 33 to MIS 30. Our results suggest the entire period currently defined as MIS 33-31 (∼1114-1062 kyr BP) was characterized by generally warm and highly variable conditions at the lake, at times out of phase with Northern Hemisphere summer insolation, and that cold "glacial" conditions during MIS 32 lasted only a few thousand years. Close similarities are seen with coeval records from high southern latitudes, supporting the suggestion that the interval from MIS 33 to MIS 31 was an exceptionally long interglacial (Teitler et al., 2015). Based on brGDGT temperatures from Lake El'gygytgyn (this study and unpublished results), warming in the western Arctic during MIS 31 was matched only by MIS 11 during the Pleistocene.

Non-random Mis-segregation of Human Chromosomes.

PubMed

Worrall, Joseph Thomas; Tamura, Naoka; Mazzagatti, Alice; Shaikh, Nadeem; van Lingen, Tineke; Bakker, Bjorn; Spierings, Diana Carolina Johanna; Vladimirou, Elina; Foijer, Floris; McClelland, Sarah Elizabeth

2018-06-12

A common assumption is that human chromosomes carry equal chances of mis-segregation during compromised cell division. Human chromosomes vary in multiple parameters that might generate bias, but technological limitations have precluded a comprehensive analysis of chromosome-specific aneuploidy. Here, by imaging specific centromeres coupled with high-throughput single-cell analysis as well as single-cell sequencing, we show that aneuploidy occurs non-randomly following common treatments to elevate chromosome mis-segregation. Temporary spindle disruption leads to elevated mis-segregation and aneuploidy of a subset of chromosomes, particularly affecting chromosomes 1 and 2. Unexpectedly, we find that a period of mitotic delay weakens centromeric cohesion and promotes chromosome mis-segregation and that chromosomes 1 and 2 are particularly prone to suffer cohesion fatigue. Our findings demonstrate that inherent properties of individual chromosomes can bias chromosome mis-segregation and aneuploidy rates, with implications for studies on aneuploidy in human disease. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

Constraining the Sahara freshwater discharge during sapropel S5 time by a stable isotope record from the Greater Sirte

NASA Astrophysics Data System (ADS)

Zirks, Eleen; Kucera, Michal; Bachem, Paul; Schulz, Hartmut

2016-04-01

The Nile River and the Black Sea were long considered as the only significant eastern Mediterranean freshwater sources and therefore inferred as the primary agents promoting surface stratification associated with sapropel formation. Sapropel S5, deposited during the last interglacial, marks a time of possible movement of Homo sapiens out of Africa. Satellite images revealed the existence of ancient rivers that once ran through the Sahara desert and drained into the Gulf of Sirte. Anomalous Nd isotope records from sapropel S5 deposits indicate that these rivers may have been active during MIS 5e, implying another freshwater source into the eastern Mediterranean Sea during that period. To constrain the extent of freshwater discharge into the Mediterranean from the Kufrah River during MIS 5e, a new δ18O record of five planktonic foraminifera species was generated from sediment core GeoTü SL 96, located proximal to the assumed outflow of the Kufrah River. The record from core GeoTü SL 96 compared with seven other records from the eastern Mediterranean Sea reveal a pattern of oxygen isotope anomalies which implies that the Kufrah River delivered detectable amount of freshwater during the second part of sapropel S5. These results reinforce the hypothesis that Sahara river systems were active during MIS 5e, which has ramifications for the understanding of sapropel events, reconstruction of coastal landscape, and the better understanding of migration routes of early humans.

Predicted bounds on peak global mean sea level during marine isotope stages 5a and 5c

NASA Astrophysics Data System (ADS)

Creveling, Jessica R.; Mitrovica, Jerry X.; Clark, Peter U.; Waelbroeck, Claire; Pico, Tamara

2017-05-01

Estimates of marine isotope stage (MIS) 5c and 5a global mean sea level (GMSL) based on marine terraces and coastal indicators range from 15-37 m and 9-30 m below present, respectively. Tectonic displacement and glacial isostatic adjustment (GIA) complicate efforts to refine this range. We revisit this issue using numerical predictions of post-glacial sea-level change and updated estimates of site-specific tectonic signals based upon these predictions. Laurentide and Cordilleran peripheral bulge dynamics and variations in the gravitational effect of these ice masses dominate the GIA signal along the east and west coasts of North America. Published compilations suggest that MIS 5 sea-level indicators extending from Virginia to the Caribbean lie on the outer flank of the peripheral bulge, while those along a transect from Oregon to Baja California sit on the inner flank of the bulge. Our GIA modeling reconciles these data by adopting a significantly weaker (i.e., lower viscosity) upper mantle in analyzing data on the Pacific coast relative to the Atlantic, an inference supported by seismic tomography. We present a sensitivity analysis that compares the observed elevation of globally distributed high stand markers to a suite of GIA simulations that vary the Earth model and GMSL from the Last Interglaciation (MIS 5e, ∼130-115 ka) to 70 ka. We conclude that GMSL peaked at -8.5 ± 4.6 m (1σ) during MIS 5a and -9.4 ± 5.3 m during MIS 5c. A more restrictive analysis yields slightly wider bounds corresponding to -10.5 ± 5.5 m and -11.1 ± 6.6 m, respectively.

Insights into MIS 3 and 4 climate in the Alps from the Baumkirchen paleo-lake site: Results of pollen analysis

NASA Astrophysics Data System (ADS)

Barrett, Samuel; Drescher-Schneider, Ruth; Starnberger, Reinhard; Spötl, Christoph

2016-04-01

The well-known Baumkirchen site of western Austria has recently been the focus of a renewed research effort. New drilling has greatly extended the length of the known lacustrine sequence to over 250 m. Luminescence dating has corroborated the late MIS 3 radiocarbon dates for the upper part of the sequence and revealed two lake phases: the upper extending from late MIS 3 back to mid MIS 3, and the lower covering late MIS 4 or early MIS 3 back possibly as far as MIS 5a. X-ray fluorescence core scanning analysis confirmed the presence of two phases which have different geochemical signals, and provided a chemistry-based stratigraphy in the visually monotonous sediments. In these uniform sediments, the only clear indication of climatic conditions from the sediments themselves is a short sequence of ice-rafted debris corresponding to the end of MIS 4. However, given their age and location within the Alps, these sediments provide an important archive of Alpine climate in the last glacial cycle. We present new results from pollen analysis and discuss them in the context of previously reported findings. Due to high sedimentation rates, pollen counts were very low. However, two stadials and two interstadials were identified. The entire lower lake phase corresponding to MIS 4 was identified as a stadial, being characterised by a very low total pollen concentrations, a dominance of herb over tree pollen and significant reworking of pre-Quaternary forms and wood fragments. The upper lake phase contains two interstadials split by an intervening stadial. The interstadials are characterised by higher total pollen concentrations and proportion of woody species including the sporadic presence of relatively warm climate species with the upper of the two appearing better developed with these indicators more strongly expressed. This upper interstadial corresponds to the location of well dated plant remains putting its age around 35 ka cal BP, strongly suggesting a correlation to

Millennial-scale variations in western Sierra Nevada precipitation during the last glacial cycle MIS 4/3 transition

NASA Astrophysics Data System (ADS)

Oster, Jessica L.; Montañez, Isabel P.; Mertz-Kraus, Regina; Sharp, Warren D.; Stock, Greg M.; Spero, Howard J.; Tinsley, John; Zachos, James C.

2014-07-01

Dansgaard-Oeschger (D-O) cycles had far-reaching effects on Northern Hemisphere and tropical climate systems during the last glacial period, yet the climatic response to D-O cycles in western North America is controversial, especially prior to 55 ka. We document changes in precipitation along the western slope of the central Sierra Nevada during early Marine Oxygen Isotope Stages (MIS) 3 and 4 (55-67 ka) from a U-series dated speleothem record from McLean's Cave. The timing of our multi-proxy geochemical dataset is coeval with D-O interstadials (15-18) and stadials, including Heinrich Event 6. The McLean's Cave stalagmite indicates warmer and drier conditions during Greenland interstadials (GISs 15-18), signified by elevated δ18O, δ13C, reflectance, and trace element concentrations, and less radiogenic 87Sr/86Sr. Our record extends evidence of a strong linkage between high-latitude warming and reduced precipitation in western North America to early MIS 3 and MIS 4. This record shows that the linkage persists in diverse global climate states, and documents the nature of the climatic response in central California to Heinrich Event 6.

Does MIS Surgery Allow for Shorter Constructs in the Surgical Treatment of Adult Spinal Deformity?

PubMed

Uribe, Juan S; Beckman, Joshua; Mummaneni, Praveen V; Okonkwo, David; Nunley, Pierce; Wang, Michael Y; Mundis, Gregory M; Park, Paul; Eastlack, Robert; Anand, Neel; Kanter, Adam; Lamarca, Frank; Fessler, Richard; Shaffrey, Chris I; Lafage, Virginie; Chou, Dean; Deviren, Vedat

2017-03-01

The length of construct can potentially influence perioperative risks in adult spinal deformity (ASD) surgery. A head-to-head comparison between open and minimally invasive surgery (MIS) techniques for treatment of ASD has yet to be performed. To examine the impact of MIS approaches on construct length and clinical outcomes in comparison to traditional open approaches when treating similar ASD profiles. Two multicenter databases for ASD, 1 involving MIS procedures and the other open procedures, were propensity matched for clinical and radiographic parameters in this observational study. Inclusion criteria were ASD and minimum 2-year follow-up. Independent t -test and chi-square test were used to evaluate and compare outcomes. A total of 1215 patients were identified, with 84 patients matched in each group. Statistical significance was found for mean levels fused (4.8 for circumferential MIS [cMIS] and 10.1 for open), mean interbody fusion levels (3.6 cMIS and 2.4 open), blood loss (estimated blood loss 488 mL cMIS and 1762 mL open), and hospital length of stay (6.7 days cMIS and 9.7 days open). There was no significant difference in preoperative radiographic parameters or postoperative clinical outcomes (Owestry Disability Index and visual analog scale) between groups. There was a significant difference in postoperative lumbar lordosis (43.3° cMIS and 49.8° open) and pelvic incidence-lumbar lordosis correction (10.6° cMIS and 5.2° open) in the open group. There was no significant difference in reoperation rate between the 2 groups. MIS techniques for ASD may reduce construct length, reoperation rates, blood loss, and length of stay without affecting clinical and radiographic outcomes when compared to a similar group of patients treated with open techniques. Copyright © 2017 by the Congress of Neurological Surgeons

Reconstruction of MIS 5 climate in the central Levant using a stalagmite from Kanaan Cave, Lebanon

NASA Astrophysics Data System (ADS)

Nehme, C.; Verheyden, S.; Noble, S. R.; Farrant, A. R.; Sahy, D.; Hellstrom, J.; Delannoy, J. J.; Claeys, P.

2015-12-01

Lying at the transition between the temperate Mediterranean domain and subtropical deserts, the Levant is a key area to study the palaeoclimatic response over glacial-interglacial cycles. This paper presents a precisely dated last interglacial (MIS 5) stalagmite (129-84 ka) from the Kanaan Cave, Lebanon. Variations in growth rate and isotopic records indicate a warm humid phase at the onset of the last interglacial at ~ 129 ka that lasted until ~ 125 ka. A gradual shift in speleothem isotopic composition (125-122 ka) is driven mainly by the δ18O source effect of the eastern Mediterranean surface waters during sapropel 5 (S5). The onset of glacial inception began after ~ 122 ka, interrupted by a short wet pulse during the sapropel 4 (S4) event. Low growth rates and enriched oxygen and carbon values until ~ 84 ka indicate a transition to drier conditions during Northern Hemisphere glaciation.

Aligning and synchronization of MIS5 proxy records from Lake Ohrid (FYROM) with independently dated Mediterranean archives: implications for DEEP core chronology

NASA Astrophysics Data System (ADS)

Zanchetta, Giovanni; Regattieri, Eleonora; Giaccio, Biagio; Wagner, Bernd; Sulpizio, Roberto; Francke, Alex; Vogel, Hendrik; Sadori, Laura; Masi, Alessia; Sinopoli, Gaia; Lacey, Jack H.; Leng, Melanie J.; Leicher, Niklas

2016-05-01

The DEEP site sediment sequence obtained during the ICDP SCOPSCO project at Lake Ohrid was dated using tephrostratigraphic information, cyclostratigraphy, and orbital tuning through the marine isotope stages (MIS) 15-1. Although this approach is suitable for the generation of a general chronological framework of the long succession, it is insufficient to resolve more detailed palaeoclimatological questions, such as leads and lags of climate events between marine and terrestrial records or between different regions. Here, we demonstrate how the use of different tie points can affect cyclostratigraphy and orbital tuning for the period between ca. 140 and 70 ka and how the results can be correlated with directly/indirectly radiometrically dated Mediterranean marine and continental proxy records. The alternative age model presented here shows consistent differences with that initially proposed by Francke et al. (2015) for the same interval, in particular at the level of the MIS6-5e transition. According to this new age model, different proxies from the DEEP site sediment record support an increase of temperatures between glacial to interglacial conditions, which is almost synchronous with a rapid increase in sea surface temperature observed in the western Mediterranean. The results show how a detailed study of independent chronological tie points is important to align different records and to highlight asynchronisms of climate events. Moreover, Francke et al. (2016) have incorporated the new chronology proposed for tephra OH-DP-0499 in the final DEEP age model. This has reduced substantially the chronological discrepancies between the DEEP site age model and the model proposed here for the last glacial-interglacial transition.

Different nature of glacial CaCO3 constituents between MIS 2 and MIS 12 in the East Sea/Japan Sea and its paleoceanographic implication

NASA Astrophysics Data System (ADS)

Khim, Boo-Keun; Tada, Ryuji; Itaki, Takuya

2014-05-01

Two piston cores (PC-05 and PC-08) were collected on the Yamato Rise in the East Sea/Japan Sea during the KR07-12 cruise. A composite core was achieved with the successful replacement of almost half of the upper part of core PC-05 by the entirety of core PC-08 based on the co-equivalence of L* values and the dark layers, because an interval (170 cm to 410 cm) of core PC-05 was considerably disturbed due to fluidization during the core execution. Chronostratigraphy of the composite core was constructed by the direct comparison of L* values to the well-dated core MD01-2407 that was obtained in the Oki Ridge. The lower-bottom of the composite core reached back to Marine Isotope Stage (MIS) 14, based on the age estimate by LR04 stacks. Downcore opal variation of the composite core exhibited the distinct orbital-scale cyclic changes; high during the interglacial and low during the glacial periods. However, downcore CaCO3 variation showed no corresponding orbital-scale cyclic change between glacial and interglacial periods. Some intervals of both periods were high in CaCO3 content. Frequent and large fluctuations in CaCO3 content seemed to be more related to the presence of dark layers containing thin lamination (TL) within the glacial and interglacial intervals. It is worthy to note that MIS 2 and MIS 12 are characterized by distinctly high CaCO3 content, showing up to 18% and 73%, respectively, among the glacial periods. Furthermore, in terms of lithology, MIS 2 was characterized by a thick dark layer (low L* values) with TL, whereas MIS 12 preserved the distinctly light layer (high L* values) with parallel laminations. Another remarkable dissimilarity between MIS 2 and MIS 12 was the nature of their CaCO3 constituent; the CaCO3 constituent of MIS 2 consisted of mostly planktonic foraminifera, whereas that of MIS 12 was mostly dump of coccolithophorids, regardless the presence of planktonic foraminifera. The distinctness of the CaCO3 constituents between MIS 2 and MIS

Minimally invasive surgery (MIS) for total knee replacement; medium term results with minimum five year follow-up.

PubMed

Unwin, Olivia; Hassaballa, Mohammed; Murray, James; Harries, William; Porteous, Andrew

2017-03-01

MIS TKA has been shown to offer a reduced in-patient stay, but no clinical difference at two years. Whilst there may be a benefit from earlier discharge, we need to ensure that there are no detrimental effects in the medium and long-term following MIS-TKA. To report the mid-term result from a prospective randomised controlled trial (RCT) comparing MIS-TKA with standard approach for TKA. Using knee score questionnaires, we collected patient reported outcome measures (PROMs) regarding pain and function. Sixty-six patients (from an eligible cohort of 83 patients) completed the mid-term postal follow-up. There was no significant difference between groups for change in score from pre-operative to final follow-up in all three PROMs. Mean MIS and standard group improvement was: AKSS 53 and 51 (p=0.7644), OKS 15 and 16 (p=0.2341) or WOMAC 15 and 15 (p=0.9900) respectively. Both groups showed improvement in pain and function with no significant difference between groups. There was no difference between groups for revision due to malalignment at a mean six year follow-up. In addition to the early benefits regarding hospital stay and complications, we have found that at a mean of six years there was no increase in malalignment, pain or function with MIS techniques. Copyright © 2017 Elsevier B.V. All rights reserved.

Cova del Rinoceront (Castelldefels, Barcelona): a terrestrial record for the Last Interglacial period (MIS 5) in the Mediterranean coast of the Iberian Peninsula

NASA Astrophysics Data System (ADS)

Daura, J.; Sanz, M.; Julià, R.; García-Fernández, D.; Fornós, J. J.; Vaquero, M.; Allué, E.; López-García, J. M.; Blain, H. A.; Ortiz, J. E.; Torres, T.; Albert, R. M.; Rodríguez-Cintas, À.; Sánchez-Marco, A.; Cerdeño, E.; Skinner, A. R.; Asmeron, Y.; Polyak, V. J.; Garcés, M.; Arnold, L. J.; Demuro, M.; Pike, A. W. G.; Euba, I.; Rodríguez, R. F.; Yagüe, A. S.; Villaescusa, L.; Gómez, S.; Rubio, A.; Pedro, M.; Fullola, J. M.; Zilhão, J.

2015-04-01

The Cova del Rinoceront, a site in NE Iberia, contains a thick sedimentary fill preserving a faunal archive from the penultimate glacial and the the last interglacial periods. Layers I to III have been dated to between 74 and 147 ka, coinciding with MIS 5a to 5e, a period poorly represented in the Mediterranean terrestrial record. The results from Cova del Rinoceront are of broader interest for the reconstruction of ecological dynamics during warm stages and the understanding of the evolution and geographical variation of several taxa. The palaeoecological evidence suggests a landscape dominated by mixed wooded vegetation with mild climatic conditions, slightly more humid than today. Several vertebrate taxa, including Haploidoceros mediterraneus, Stephanorhinus hundsheimensis and Glis glis, are documented for the first time in the early Upper Pleistocene of Europe, showing that these species persisted across the region for longer than previously thought. In addition, the recovery of a small lithic assemblage indicates human presence in the surroundings of the site. The 11 m-thick stratigraphic section also provides an ideal setting in which to compare several geochronological methods. U-Th dating of the flowstones that cap the deposit, of speleothems formed along the cave walls, and of speleothems buried by the deposit at different elevations provides minimum and maximum ages of 74 and 175 ka, respectively, for the accumulation. The ages obtained by luminescence, electron spin resonance (ESR), amino acid racemisation (AAR), palaeomagnetism and U-series dating of bone are in good agreement with each other and are stratigraphically consistent. This well-dated faunal succession presents a unique opportunity to assess changes in the Pleistocene fauna of the Mediterranean coast over an interval of more than 100 ka.

Mis-Spliced Lr34 Transcript Events in Winter Wheat.

PubMed

Fang, Tilin; Carver, Brett F; Hunger, Robert M; Yan, Liuling

2017-01-01

Lr34 in wheat is a non-race-specific gene that confers resistance against multiple fungal pathogens. The resistant allele Lr34 and the susceptible allele Lr34s can be distinguished by three polymorphisms that cause alternation of deduced amino acid sequences of Lr34 at the protein level. In seedlings of a cultivar carrying the resistant Lr34r allele, only a portion (35%) of its transcripts was correctly spliced and the majority (65%) of its transcripts were incorrectly spliced due to multiple mis-splicing events. Lr34 mis-splicing events were also observed at adult plant age when this gene exerts its function. All of the mis-spliced Lr34r cDNA transcripts observed in this study resulted in a premature stop codon due to a shift of the open reading frame; hence, the mis-spliced Lr34r cDNAs were deduced to encode incomplete proteins. Even if a cultivar has a functional Lr34 gene, its transcripts might not completely splice in a correct pattern. These findings suggested that the partial resistance conferred by a quantitative gene might be due to mis-splicing events in its transcripts; hence, the resistance of the gene could be increased by eliminating or mutating regulators that cause mis-splicing events in wheat.

MIS - The Human Connection

PubMed Central

Bush, Ian E.

1980-01-01

The lessons of the 70's with MIS were largely painful, often the same as those of the 60's, and were found in different phases on two continents. On examination this turns out to be true for many non-medical fields, true for systems programming, and thus a very general phenomenon. It is related to the functional complexity rather than to the sheer size of the software required, and above all to the relative neglect of human factors at all levels of software and hardware design. Simple hierarchical theory is a useful tool for analyzing complex systems and restoring the necessary dominance of common sense human factors. An example shows the very large effects of neglecting these factors on costs and benefits of MIS and their sub-systems.

Si and GaAs photocapacitive MIS infrared detectors

NASA Technical Reports Server (NTRS)

Sher, A.; Tsuo, Y. H.; Moriarty, J. A.; Miller, W. E.; Crouch, R. K.

1980-01-01

Improvement of the previously reported photocapacitive MIS infrared detectors has led to the development of exceptional room-temperature devices. Unoptimized peak detectivities on the order of 10 to the 13th cm sq rt Hz/W, a value which exceeds the best obtainable from existing solid-state detectors, have now been consistently obtained in Si and GaAs devices using high-capacitance LaF3 or composite LaF3/native-oxide insulating layers. The measured spectral response of representative samples is presented and discussed in detail together with a simple theory which accounts for the observed behavior. The response of an ideal MIS photocapacitor is also contrasted with that of both a conventional photoconductor and a p-i-n photodiode, and reasons for the superior performance of the MIS detectors are given. Finally, fundamental studies on the electrical, optical, and noise characteristics of the MIS structures are analyzed and discussed in the context of infrared-detector applications.

(Mis)perceptions of inequality.

PubMed

Hauser, Oliver P; Norton, Michael I

2017-12-01

Laypeople's beliefs about the current distribution of outcomes such as income and wealth in their country influence their attitudes toward issues ranging from taxation to healthcare - but how accurate are these beliefs? We review the burgeoning literature on (mis)perceptions of inequality. First, we show that people on average misperceive current levels of inequality, typically underestimating the extent of inequality in their country. Second, we delineate potential causes of these misperceptions, including people's overreliance on cues from their local environment, leading to their erroneous beliefs about both the overall distributions of wealth and income and their place in those distributions. Third, we document that these (mis)perceptions of inequality - but not actual levels of inequality - drive behavior and preferences for redistribution. More promisingly, we review research suggesting that correcting misperceptions influences preferences and policy outcomes. Copyright © 2017 Elsevier Ltd. All rights reserved.

Combined ice core and climate-model evidence for the collapse of the West Antarctic Ice Sheet during Marine Isotope Stage 5e.

NASA Astrophysics Data System (ADS)

Steig, Eric J.; Huybers, Kathleen; Singh, Hansi A.; Steiger, Nathan J.; Frierson, Dargan M. W.; Popp, Trevor; White, James W. C.

2015-04-01

It has been speculated that collapse of the West Antarctic Ice Sheet explains the very high eustatic sea level rise during the last interglacial period, marine isotope stage (MIS) 5e, but the evidence remains equivocal. Changes in atmospheric circulation resulting from a collapse of the West Antarctic Ice Sheet (WAIS) would have significant regional impacts that should be detectable in ice core records. We conducted simulations using general circulation models (GCMs) at varying levels of complexity: a gray-radiation aquaplanet moist GCM (GRaM), the slab ocean version of GFDL-AM2 (also as an aquaplanet), and the fully-coupled version of NCAR's CESM with realistic topography. In all the experiments, decreased elevation from the removal of the WAIS leads to greater cyclonic circulation over the West Antarctic region. This creates increased advection of relatively warm marine air from the Amundsen-Bellingshausen Seas towards the South Pole, and increased cold-air advection from the East Antarctic plateau towards the Ross Sea and coastal Marie Byrd Land. The result is anomalous warming in some areas of the East Antarctic interior, and significant cooling in Marie Byrd Land. Comparison of ice core records shows good agreement with the model predictions. In particular, isotope-paleotemperature records from ice cores in East Antarctica warmed more between the previous glacial period (MIS 6) and MIS 5e than coastal Marie Byrd Land. These results add substantial support to other evidence for WAIS collapse during the last interglacial period.

Reconstructing dust fluxes and paleoproductivity at the southern Agulhas Plateau since MIS-6

NASA Astrophysics Data System (ADS)

Frenkel, M. M.; Anderson, R. F.; Winckler, G.

2017-12-01

Understanding the mechanisms underlying glacial-interglacial cycles requires characterizing the role of oceanic feedbacks in climatic changes. For example, increased aeolian iron fluxes to Fe-limited regions of the ocean and corresponding changes in marine productivity could have improved biological pump efficiency and resulted in CO2 drawdown. Here we explore these feedbacks using marine sediment core MDO2-2588 collected from the southern Agulhas Plateau (SAP; 41°S, 26°E), located beneath the modern subtropical front. Today, diatom productivity in this region is Si-limited because high Si utilization south of the polar front (PF) means that water advected northward to our study site is Si-depleted. However, previous work has suggested that extended sea ice cover during glacial periods may have limited diatom productivity south of the PF while frontal systems shifted northward, allowing more Si to reach thermocline of the SAP. Meanwhile, increased glacial dust flux to the SAP may have simultaneously supplied more Fe, contributing to higher glacial productivity. This hypothesis has been supported by observations of higher LGM and MIS-6 productivity at MD02-2588 using bulk biogenic content and diatom assemblages (Romero et al., Paleoceanography, 30 (2015) 118-132). Gradients in d13C between benthic and planktic foraminifera have also been used to support Fe fertilization at this site on millennial timescales (Ziegler et al., Nature Geoscience, 6 (2013) 457-461). Yet, studies have yet to produce coordinated records of dust flux and export production for the SAP. Here, we present records of dust, based on 230Th-normalized 232Th fluxes, and export production using 230Th-normalized excess-Ba and opal fluxes and authigenic U through MIS-6. Preliminary results show that lithogenic fluxes to MD02-2588 were approximately twice as high during MIS-6 as MIS-5e and were concurrent with a two-fold increase in excess-Ba flux. However, this relative increase in lithogenic flux

Relative sea level and coastal environments in arctic Alaska during Marine Isotope Stage 5

NASA Astrophysics Data System (ADS)

Farquharson, L. M.; Mann, D. H.; Jones, B. M.; Rittenour, T. M.; Grosse, G.; Groves, P.

2015-12-01

Marine Isotope Stage (MIS) 5 was characterized by marked fluctuations in climate, the warmest being MIS 5e (124-119 ka) when relative sea level (RSL) stood 2-10 m higher than today along many coastlines. In northern Alaska, marine deposits now 5-10 m above modern sea level are assigned to this time period and termed the Pelukian transgression (PT). Complicating this interpretation is the possibility that an intra-Stage 5 ice shelf extended along the Alaskan coast, causing isostatic depression along its grounded margins, which caused RSL highs even during periods of low, global RSL. Here we use optically stimulated luminescence (OSL) to date inferred PT deposits on the Beaufort Sea coastal plain. A transition from what we interpret to be lagoonal mud to sandy tidal flat deposits lying ~ 2.75 m asl dates to 113+/-18 ka. Above this, a 5-m thick gravelly barrier beach dates to 95 +/- 20 ka. This beach contains well-preserved marine molluscs, whale vertebrae, and walrus tusks. Pleistocene-aged ice-rich eolian silt (yedoma) blanket the marine deposits and date to 57.6 +/-10.9 ka. Our interpretation of this chronostratigraphy is that RSL was several meters higher than today during MIS 5e, and lagoons or brackish lakes were prevalent. Gravel barrier beaches moved onshore as local RSL rose further after MIS 5e. The error range of the OSL age of the barrier-beach unit spans the remaining four substages of MIS 5; however, the highstand of RSL on this arctic coastline appears to occurr after the warmest part of the last interglacial and appears not to be coeval with the eustatic maximum reached at lower latitudes during MIS 5. One possibility is that RSL along the Beaufort Sea coast was affected by isostatic depression caused by an ice shelf associated with widespread, intra-Stage 5 glaciation that was out of phase with lower latitude glaciation and whose extent and timing remains enigmatic.

On the Formation of Meridional Overturning Circulation in the Pacific Ocean during the MIS31 Interglacial

NASA Astrophysics Data System (ADS)

Justino, F. J.; Lindemann, D.; Kucharski, F.

2016-02-01

Earth climate history has been punctuated by cold (glacial) and warm (inter-glacial) intervals associated with modification of the planetary orbit and subsequently changes in paleotopography.During the Pleistocene epoch, the time interval between 1.8 million and 11,700 before present, remarkable episodes of warmer climates such as the Marine IsotopeStage (MIS) 1, 5e, 11c, and 31 which occurred at 9, 127, 409, and 1080 ka, lead to changes in air temperature in the polar regions and substantial melting of polar glaciers. Based on first ever multi-millennium coupled climate simulations of the Marine Isotope Stage 31 (MIS31), long-term oceanic conditions characteristic of this interval have been analyzed. Modeling experiments forced by modified West Antarctic Ice Sheet (WAIS) topography and astronomical configuration, demonstrated that substantial increase in the thermohaline flow and its associated northward heat transport in both Atlantic and Pacific oceans are predicted to occur during the MIS31. In the Atlantic these changes are driven by enhanced oceanic heat loss and increased water density. In the Pacific, anomalous atmospheric circulation leads to an overall increase of the water mass transport in the subtropical gyre, and drastically modified subtropical cell.Additional aspects related to the formation of the Pacific ocean MOC will be presented. This study is sponsored by the Brazilian Antarctic Program Grant CNPq 407681/2013-2.

Aligning MIS5 proxy records from Lake Ohrid (FYROM) with independently dated Mediterranean archives: implications for core chronology

NASA Astrophysics Data System (ADS)

Zanchetta, G.; Regattieri, E.; Giaccio, B.; Wagner, B.; Sulpizio, R.; Francke, A.; Vogel, L. H.; Sadori, L.; Masi, A.; Sinopoli, G.; Lacey, J. H.; Leng, M. L.; Leicher, N.

2015-10-01

The DEEP site sediment sequence obtained during the ICDP SCOPSCO project at Lake Ohrid was dated using tephrostratigraphic information, cyclostratigraphy, and orbital tuning through marine isotope record. Although this approach is suitable for the generation of a general chronological framework of the long succession, it is insufficient to resolve more detailed paleoclimatological questions, such as leads and lags of climate events between marine and terrestrial records or between different regions. In this paper, we demonstrate how the use of different tie points can affect cyclostratigraphy and orbital tuning for the period between ca. 140 and 70 ka and how the results can be correlated with directly/indirectly radiometrically-dated Mediterranean marine and continental proxy records. The alternative age model obtained shows consistent differences with that proposed by Francke et al. (2015) for the same interval, in particular at the level of the MIS6-5e transition. According to this age model, different proxies from the DEEP site sediment record support an increase of temperatures between glacial to interglacial conditions, which is almost synchronous with a rapid increase in sea surface temperature observed in the western Mediterranean. The results show how important a detailed study of independent chronological tie points is for synchronizing different records and to highlight asynchronisms of climate events.

BatMis: a fast algorithm for k-mismatch mapping.

PubMed

Tennakoon, Chandana; Purbojati, Rikky W; Sung, Wing-Kin

2012-08-15

Second-generation sequencing (SGS) generates millions of reads that need to be aligned to a reference genome allowing errors. Although current aligners can efficiently map reads allowing a small number of mismatches, they are not well suited for handling a large number of mismatches. The efficiency of aligners can be improved using various heuristics, but the sensitivity and accuracy of the alignments are sacrificed. In this article, we introduce Basic Alignment tool for Mismatches (BatMis)--an efficient method to align short reads to a reference allowing k mismatches. BatMis is a Burrows-Wheeler transformation based aligner that uses a seed and extend approach, and it is an exact method. Benchmark tests show that BatMis performs better than competing aligners in solving the k-mismatch problem. Furthermore, it can compete favorably even when compared with the heuristic modes of the other aligners. BatMis is a useful alternative for applications where fast k-mismatch mappings, unique mappings or multiple mappings of SGS data are required. BatMis is written in C/C++ and is freely available from http://code.google.com/p/batmis/

The Relationship between Motor, Imitation, and Early Social Communication Skills in Children with Autism.

PubMed

Dadgar, Hooshang; Alaghband Rad, Javad; Soleymani, Zahra; Khorammi, Anahita; McCleery, Joe; Maroufizadeh, Saman

2017-10-01

Objective: Development of early social skills in children is a complex process. To understand this process, it is important to assess how strengths or weaknesses in other developmental domains may be affected by these skills. The present study aimed at investigating the association of motor skills and imitation ability with early social communication skills in children with autism spectrum disorder (ASD). Method: In this study, 20 children with ASD aged 3 to 5 years (M = 4.05, SD = 0.55) participated. All children were diagnosed as ASD based on the DSM-V criteria by an independent child psychiatrist. Additionally, Autism Diagnostic interview-Revised was used for subsequent diagnostic confirmation. Children were tested with Test of Gross Motor Development (TGMD-2), the Motor Imitation Scale (MIS), and the Early Social Communication Scales (ESCS). All examinations were videotaped for subsequent scoring. The relationship between these skills was estimated by Pearson correlation coefficient. Results: A significant and strong correlation was obtained between TGMD total score and imitation total score (r =.776; p <0.001). However, the relationship between MIS subscales and TGMD-2 locomotor subtest scores was not significant (P>0.05). A significant correlation was found between MIS and TGMD total scores with Initiating Joint Attention and Responding to Joint Attention (p≤0/025) as ESCS subscales. But MIS and TGMD total scores were not correlated with social interaction and responding to behavioral requests subscales. Conclusion: The results of the present study showed that indicated both imitation ability and motor function have an association with each other and with early social communication skills.

The Relationship between Motor, Imitation, and Early Social Communication Skills in Children with Autism

PubMed Central

Dadgar, Hooshang; Alaghband Rad, Javad; Soleymani, Zahra; Khorammi, Anahita; McCleery, Joe; Maroufizadeh, Saman

2017-01-01

Objective: Development of early social skills in children is a complex process. To understand this process, it is important to assess how strengths or weaknesses in other developmental domains may be affected by these skills. The present study aimed at investigating the association of motor skills and imitation ability with early social communication skills in children with autism spectrum disorder (ASD). Method: In this study, 20 children with ASD aged 3 to 5 years (M = 4.05, SD = 0.55) participated. All children were diagnosed as ASD based on the DSM-V criteria by an independent child psychiatrist. Additionally, Autism Diagnostic interview-Revised was used for subsequent diagnostic confirmation. Children were tested with Test of Gross Motor Development (TGMD-2), the Motor Imitation Scale (MIS), and the Early Social Communication Scales (ESCS). All examinations were videotaped for subsequent scoring. The relationship between these skills was estimated by Pearson correlation coefficient. Results: A significant and strong correlation was obtained between TGMD total score and imitation total score (r =.776; p <0.001). However, the relationship between MIS subscales and TGMD-2 locomotor subtest scores was not significant (P>0.05). A significant correlation was found between MIS and TGMD total scores with Initiating Joint Attention and Responding to Joint Attention (p≤0/025) as ESCS subscales. But MIS and TGMD total scores were not correlated with social interaction and responding to behavioral requests subscales. Conclusion: The results of the present study showed that indicated both imitation ability and motor function have an association with each other and with early social communication skills. PMID:29472949

MIS capacitor studies on silicon carbide single crystals

NASA Technical Reports Server (NTRS)

Kopanski, J. J.

1990-01-01

Cubic SIC metal-insulator-semiconductor (MIS) capacitors with thermally grown or chemical-vapor-deposited (CVD) insulators were characterized by capacitance-voltage (C-V), conductance-voltage (G-V), and current-voltage (I-V) measurements. The purpose of these measurements was to determine the four charge densities commonly present in an MIS capacitor (oxide fixed charge, N(f); interface trap level density, D(it); oxide trapped charge, N(ot); and mobile ionic charge, N(m)) and to determine the stability of the device properties with electric-field stress and temperature. The section headings in the report include the following: Capacitance-voltage and conductance-voltage measurements; Current-voltage measurements; Deep-level transient spectroscopy; and Conclusions (Electrical characteristics of SiC MIS capacitors).

HPV16 early gene E5 specifically reduces miRNA-196a in cervical cancer cells

PubMed Central

Liu, Chanzhen; Lin, Jianfei; Li, Lianqin; Zhang, Yonggang; Chen, Weiling; Cao, Zeyi; Zuo, Huancong; Chen, Chunling; Kee, Kehkooi

2015-01-01

High-risk human papillomavirus (HPV) type 16, which is responsible for greater than 50% of cervical cancer cases, is the most prevalent and lethal HPV type. However, the molecular mechanisms of cervical carcinogenesis remain elusive, particularly the early steps of HPV infection that may transform normal cervical epithelium into a pre-neoplastic state. Here, we report that a group of microRNAs (microRNAs) were aberrantly decreased in HPV16-positive normal cervical tissues, and these groups of microRNAs are further reduced in cervical carcinoma. Among these miRNAs, miR196a expression is the most reduced in HPV16-infected tissues. Interestingly, miR196a expression is low in HPV16-positive cervical cancer cell lines but high in HPV16-negative cervical cancer cell lines. Furthermore, we found that only HPV16 early gene E5 specifically down-regulated miRNA196a in the cervical cancer cell lines. In addition, HoxB8, a known miR196a target gene, is up-regulated in the HPV16 cervical carcinoma cell line but not in HPV18 cervical cancer cell lines. Various doses of miR196a affected cervical cancer cell proliferation and apoptosis. Altogether, these results suggested that HPV16 E5 specifically down-regulates miR196a upon infection of the human cervix and initiates the transformation of normal cervix cells to cervical carcinoma. PMID:25563170

AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy.

PubMed

Kano, Motohiro; Sosulski, Amanda E; Zhang, LiHua; Saatcioglu, Hatice D; Wang, Dan; Nagykery, Nicholas; Sabatini, Mary E; Gao, Guangping; Donahoe, Patricia K; Pépin, David

2017-02-28

The ovarian reserve represents the stock of quiescent primordial follicles in the ovary which is gradually depleted during a woman's reproductive lifespan, resulting in menopause. Müllerian inhibiting substance (MIS) (or anti-Müllerian hormone/AMH), which is produced by granulosa cells of growing follicles, has been proposed as a negative regulator of primordial follicle activation. Here we show that long-term parenteral administration of superphysiological doses of MIS, using either an adeno-associated virus serotype 9 (AAV9) gene therapy vector or recombinant protein, resulted in a complete arrest of folliculogenesis in mice. The ovaries of MIS-treated mice were smaller than those in controls and did not contain growing follicles but retained a normal ovarian reserve. When mice treated with AAV9/MIS were paired with male breeders, they exhibited complete and permanent contraception for their entire reproductive lifespan, disrupted vaginal cycling, and hypergonadotropic hypogonadism. However, when ovaries from AAV9-MIS-treated mice were transplanted orthotopically into normal recipient mice, or when treatment with the protein was discontinued, folliculogenesis resumed, suggesting reversibility. One of the important causes of primary ovarian insufficiency is chemotherapy-induced primordial follicle depletion, which has been proposed to be mediated in part by increased activation. To test the hypothesis that MIS could prevent chemotherapy-induced overactivation, mice were given carboplatin, doxorubicin, or cyclophosphamide and were cotreated with AAV9-MIS, recombinant MIS protein, or vehicle controls. We found significantly more primordial follicles in MIS-treated animals than in controls. Thus treatment with MIS may provide a method of contraception with the unique characteristic of blocking primordial follicle activation that could be exploited to prevent the primary ovarian insufficiency often associated with chemotherapy.

A multi-proxy record of MIS 11-12 deglaciation and glacial MIS 12 instability from the Sulmona basin (central Italy)

NASA Astrophysics Data System (ADS)

Regattieri, Eleonora; Giaccio, Biagio; Galli, Paolo; Nomade, Sebastien; Peronace, Edoardo; Messina, Paolo; Sposato, Andrea; Boschi, Chiara; Gemelli, Maurizio

2016-01-01

A multi-proxy record (lithology, XRF, CaCO3 content, carbonate δ18O and δ13C) was acquired from a sediment core drilled in the intermountain Sulmona basin (central Italy). Tephrostratigraphic analyses of three volcanic ash layers ascribe the investigated succession to the MIS 12-MIS 11 period, spanning the interval ca. 500-410 ka. Litho-pedo facies assemblage indicates predominant lacustrine deposition, interrupted by a minor sub-aerial and lake low stand episode. Variations in major and minor elements concentrations are related to changes in the clastic input to the lake. The oxygen isotopic composition of carbonate (δ18Oc) intervals is interpreted mainly as a proxy for the amount of precipitation in the high-altitude catchment of the karst recharge system. The record shows pronounced hydrological variability at orbital and millennial time-scales, which appears closely related to the Northern Hemisphere summer insolation pattern and replicates North Atlantic and west Mediterranean Sea Surface Temperature (SST) fluctuations. The MIS 12 glacial inception is marked by an abrupt reduction of precipitation, lowering of the lake level and enhanced catchment erosion. A well-defined and isotopically prominent interstadial with increased precipitation maybe related to insolation maxima-precession minima at ca. 465 ka. This interstadial ends abruptly at ca. 457 ka and it is followed by a phase of strong short-term instability. Drastic lake-level lowering and enhanced clastic flux characterized the MIS 12 glacial maximum. Lacustrine deposition restarted about 440 ka ago. The MIS 12-MIS 11 transition is characterized by a rapid increase in the precipitation, lake-level rise and reduction in the clastic input, interrupted by a short and abrupt return to drier conditions. Comparison with marine records from the Iberian margin and western Mediterranean suggests that major events of ice rafted debris deposition, related to southward migrations of the polar front, match the

a Coupled GCM Comparison of Marine Isotope Stages 1, 5e, 11c and 31 IN Relation to Lake El'gygytgyn, NE Russia

NASA Astrophysics Data System (ADS)

Coletti, A. J.; DeConto, R.; Melles, M.; Brigham-Grette, J.; Minyuk, P.

2012-12-01

The lack of scientific data concerning interglacials of the Pleistocene in the Arctic has been a major obstacle within the climate community. Study of the interglacials of Marine Isotope Stage(s) (MIS) 1, 5e, 11c and 31 in high latitudes is important to decoding Arctic sensitivity and providing us with a potential analogue for a future Arctic with climate change. Data from a sediment core recovered from Lake El'Gygytgyn in northeastern (NE) Russia gives a continuous, high-resolution record of the Arctic spanning the past 2.8 million years whilst recording these interglacials. The data was used to correlate simulated interglacial Arctic climate with Arctic climate derived from sediment core proxy studies. Here, we use a Global Circulation Model (GCM) with a coupled atmosphere and land-surface scheme complete with an interactive vegetation component to simulate marine isotope stages 1, 5e, 11c and 31 in the Arctic. GCM simulations of MIS 5e and 31 in the Arctic both show a warmer arctic climate that can be explained by high obliquity, high eccentricity, high CO2 (287 ppmv ,325 ppmv , respectively) and precession that aligns perihelion with boreal summer. Consequently, MIS 5e showed the greatest summer warming compared to the other interglacials and pre-industrial control. However, the distinctly higher values of mean temperature of the warmest month (MTWM) and annual precipitation during stage 11c cannot readily be explained by summer orbital forcings and greenhouse gas (GHG) concentrations. Montane forest is seen migrating northward in stages 1, 5e and 31 as the surface insolation increases and sea ice melts, whereas in 11c, the warmest of the interglacials, evergreen forest takes over and migrates pole ward toward the coast. Feedback from low albedo forest biome was studied and conclusions suggest the increase in temperature due to forest cover is insignificant in creating a significantly warm regional climate. The warming associated with a lack of a Greenland Ice

Late Pleistocene (MIS5-3) environmental reconstruction from north-eastern Iberia through microvertebrate and palaeobotanical records

NASA Astrophysics Data System (ADS)

Allue, Ethel; Bennàssar, Maria; Biltekin, Demet; Blain, Hugues-Alexandre; Burjachs, Francesc; Euba, Itxaso; Expósito, Isabel; Fernández-García, Mónica; López-García, Juan Manuel

2014-05-01

The aim of this work is to analyze the environmental changes during the Late Pleistocene on the basis of a multi-approach study based on natural and archaeological deposits from NE Iberian Peninsula. The focussed area, although having a small extension (some 32.000 square kilometres), covers a large range of ecosystems and bioclimatic conditions from the Mediterranean seashore to the summit of the Pyrenean mountain ranges (up to 2000 masl). This synthetical approach includes materials from various contexts including 10 archaeological deposits and a single natural deposit. In this work, plant (pollen and charcoals) and animal (small mammals, amphibians and reptiles) records are being analysed and compared in order to present an overview of the environmental changes occurred from the MIS5 to MIS3. On the first hand, we are using the small-vertebrate records recovered from archaeological deposits. These proxies are mainly the product of pellets from birds of prey and are key ecological markers. On the second hand, palaeobotanical evidences, pollen and charcoal, have different formation processes. Charcoal remains are mostly from archaeological deposits and are due to human activities related to fire showing evidences of the local vegetation. Pollen evidences from archaeological and natural contexts are deposited through natural processes (wind, insects, etc.) and show regional scale vegetation record. Results indicate the presence of temperate elements during all these periods (especially at the seashore area), with a more important representation and extension southwards or changes in altitude from taxa with eurosiberian affinities during coldest periods. Forest coverage, plant and vertebrate distribution along the territory point out a mosaic landscape formed by open areas and forests. These landscapes have probably a more or less Mediterranean or Eurosiberian character depending on the climatic moment and their location with variations along the sequence.

Genetic therapies for RNA mis-splicing diseases.

PubMed

Hammond, Suzan M; Wood, Matthew J A

2011-05-01

RNA mis-splicing diseases account for up to 15% of all inherited diseases, ranging from neurological to myogenic and metabolic disorders. With greatly increased genomic sequencing being performed for individual patients, the number of known mutations affecting splicing has risen to 50-60% of all disease-causing mutations. During the past 10years, genetic therapy directed toward correction of RNA mis-splicing in disease has progressed from theoretical work in cultured cells to promising clinical trials. In this review, we discuss the use of antisense oligonucleotides to modify splicing as well as the principles and latest work in bifunctional RNA, trans-splicing and modification of U1 and U7 snRNA to target splice sites. The success of clinical trials for modifying splicing to treat Duchenne muscular dystrophy opens the door for the use of splicing modification for most of the mis-splicing diseases. Copyright © 2011 Elsevier Ltd. All rights reserved.

The use of Mohs micrographic surgery (MMS) for melanoma in situ (MIS) of the trunk and proximal extremities.

PubMed

Stigall, Landon E; Brodland, David G; Zitelli, John A

2016-11-01

Evaluation of the entire surgical margin results in high rates of complete excision, low local recurrence rates, and maximal tissue conservation. Although well recognized for melanoma of the head and neck, few studies have focused exclusively on the trunk and proximal extremities. We sought to evaluate the efficacy of Mohs micrographic surgery for melanoma in situ (MIS) of the trunk and proximal extremities, and determine adequate excision margins for MIS when total margin evaluation is not used. Long-term outcomes in 882 cases of MIS treated with Mohs micrographic surgery were analyzed and compared with historical controls. Rates of complete excision were determined for increasing surgical margin intervals. One local recurrence occurred in our cohort (0.1%). Only 83% of MIS were excised with a 6-mm margin. Margins of 9 mm were needed to excise 97% of MIS, statistically equivalent to thin melanomas. We used a nonrandomized, single-institution, retrospective design. Mohs micrographic surgery may cure the 17% of MIS that exceed traditional excision margins of 5 mm and is a valuable option for these patients. Surgical margins of at least 0.9 cm should be considered for MIS of the trunk and extremities when total margin evaluation is not used. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Lithic technological responses to Late Pleistocene glacial cycling at Pinnacle Point Site 5-6, South Africa

PubMed Central

Brown, Kyle S.; Oestmo, Simen; Pereira, Telmo; Ranhorn, Kathryn L.; Schoville, Benjamin J.; Marean, Curtis W.

2017-01-01

There are multiple hypotheses for human responses to glacial cycling in the Late Pleistocene, including changes in population size, interconnectedness, and mobility. Lithic technological analysis informs us of human responses to environmental change because lithic assemblage characteristics are a reflection of raw material transport, reduction, and discard behaviors that depend on hunter-gatherer social and economic decisions. Pinnacle Point Site 5–6 (PP5-6), Western Cape, South Africa is an ideal locality for examining the influence of glacial cycling on early modern human behaviors because it preserves a long sequence spanning marine isotope stages (MIS) 5, 4, and 3 and is associated with robust records of paleoenvironmental change. The analysis presented here addresses the question, what, if any, lithic assemblage traits at PP5-6 represent changing behavioral responses to the MIS 5-4-3 interglacial-glacial cycle? It statistically evaluates changes in 93 traits with no a priori assumptions about which traits may significantly associate with MIS. In contrast to other studies that claim that there is little relationship between broad-scale patterns of climate change and lithic technology, we identified the following characteristics that are associated with MIS 4: increased use of quartz, increased evidence for outcrop sources of quartzite and silcrete, increased evidence for earlier stages of reduction in silcrete, evidence for increased flaking efficiency in all raw material types, and changes in tool types and function for silcrete. Based on these results, we suggest that foragers responded to MIS 4 glacial environmental conditions at PP5-6 with increased population or group sizes, ‘place provisioning’, longer and/or more intense site occupations, and decreased residential mobility. Several other traits, including silcrete frequency, do not exhibit an association with MIS. Backed pieces, once they appear in the PP5-6 record during MIS 4, persist through MIS

Lithic technological responses to Late Pleistocene glacial cycling at Pinnacle Point Site 5-6, South Africa.

PubMed

Wilkins, Jayne; Brown, Kyle S; Oestmo, Simen; Pereira, Telmo; Ranhorn, Kathryn L; Schoville, Benjamin J; Marean, Curtis W

2017-01-01

There are multiple hypotheses for human responses to glacial cycling in the Late Pleistocene, including changes in population size, interconnectedness, and mobility. Lithic technological analysis informs us of human responses to environmental change because lithic assemblage characteristics are a reflection of raw material transport, reduction, and discard behaviors that depend on hunter-gatherer social and economic decisions. Pinnacle Point Site 5-6 (PP5-6), Western Cape, South Africa is an ideal locality for examining the influence of glacial cycling on early modern human behaviors because it preserves a long sequence spanning marine isotope stages (MIS) 5, 4, and 3 and is associated with robust records of paleoenvironmental change. The analysis presented here addresses the question, what, if any, lithic assemblage traits at PP5-6 represent changing behavioral responses to the MIS 5-4-3 interglacial-glacial cycle? It statistically evaluates changes in 93 traits with no a priori assumptions about which traits may significantly associate with MIS. In contrast to other studies that claim that there is little relationship between broad-scale patterns of climate change and lithic technology, we identified the following characteristics that are associated with MIS 4: increased use of quartz, increased evidence for outcrop sources of quartzite and silcrete, increased evidence for earlier stages of reduction in silcrete, evidence for increased flaking efficiency in all raw material types, and changes in tool types and function for silcrete. Based on these results, we suggest that foragers responded to MIS 4 glacial environmental conditions at PP5-6 with increased population or group sizes, 'place provisioning', longer and/or more intense site occupations, and decreased residential mobility. Several other traits, including silcrete frequency, do not exhibit an association with MIS. Backed pieces, once they appear in the PP5-6 record during MIS 4, persist through MIS 3

Atmospheric CO2 variations on millennial-scale during MIS 6

NASA Astrophysics Data System (ADS)

Shin, Jinhwa; Grilli, Roberto; Chappellaz, Jérôme; Teste, Grégory; Nehrbass-Ahles, Christoph; Schmidely, Loïc; Schmitt, Jochen; Stocker, Thomas; Fischer, Hubertus

2017-04-01

Understanding natural carbon cycle / climate feedbacks on various time scales is highly important for predicting future climate changes. Paleoclimate records of Antarctic temperatures, relative sea level and foraminiferal isotope and pollen records in sediment cores from the Portuguese margin have shown climate variations on millennial time scale over the Marine Isotope Stage 6 (MIS 6; from approximately 135 to 190 kyr BP). These proxy data suggested iceberg calving in the North Atlantic result in cooling in the Northern hemisphere and warming in Antarctica by changes in the Atlantic Meridional Overturning Circulation, which is explained by a bipolar see-saw trend in the ocean (Margari et al., 2010). Atmospheric CO2 reconstruction from Antarctic ice cores can provide key information on how atmospheric CO2 concentrations are linked to millennial-scale climate changes. However, existing CO2 records cannot be used to address this relationship because of the lack of suitable temporal resolution. In this work, we will present a new CO2 record with an improved time resolution, obtained from the Dome C ice core (75˚ 06'S, 123˚ 24'E) spanning the MIS 6 period, using dry extraction methods. We will examine millennial-scale features in atmospheric CO2, and their possible links with other proxies covering MIS 6. Margari, V., Skinner, L. C., Tzedakis, P. C., Ganopolski, A., Vautravers, M., and Shackleton, N. J.: The nature of millennial scale climate variability during the past two glacial periods, Nat.Geosci., 3, 127-131, 2010.

Marine-to-lacustrine transition, mud volcanism, and slope instability in an active tectonic setting: the MIS 5 to 4 transition in the Sea of Marmara, Turkey

NASA Astrophysics Data System (ADS)

Grall, Céline; Henry, Pierre; Kendé, Julia; Namık Çaǧatay, M.; Kadir Eriş, K.; Paillès, Christine; Sorlien, Christopher; Shillington, Donna; McHugh, Cecilia; Steckler, Michael; Çifçi, Günay; Géli, Louis

2016-04-01

MTDs. At the transition from Marine Isotope Stage (MIS) 5 to 4, sea-level fell from 25 to 85 m below the modern sea-level resulting in the disconnection of the Sea of Marmara. Sapropels deposited on the shelf before the disconnection and are attributed to MIS-5 (Cagatay et al. 2009). Grall et al, (2014) proposed that MTDs found above the Red-H1 were deposited at the beginning of MIS-4 at ~70 ka and that MTD complexes found during earlier glacial cycles also accumulated after marine to lacustrine-disconnections, possibly in relation with hydrate dissociation and/or clay swelling. Buried mud volcanoes located within the NNAF damage zone pierce the Red-H1 reflector but not the reflector above, suggesting that the last main eruption may also happens at the beginning of MIS-4. We will present preliminary assessment of the paleoenvironmental changes across the MIS-5 to 4 transition from bio-indicators and geochemistry.

Continuity versus discontinuity of the human settlement of Europe between the late Early Pleistocene and the early Middle Pleistocene. The mandibular evidence

NASA Astrophysics Data System (ADS)

Bermúdez de Castro, José María; Martinón-Torres, María; Rosell, Jordi; Blasco, Ruth; Arsuaga, Juan Luís; Carbonell, Eudald

2016-12-01

One of the most interesting aspects of the settlement of Europe is the possible continuity or discontinuity of the populations living in this continent during the Early and Middle Pleistocene. In this paper we present an analysis of the mandibular fossil record from four important Pleistocene European sites, Gran Dolina-TD6-2 (Sierra de Atapuerca), Mauer, Arago, and Atapuerca-Sima de los Huesos. We focus this study in the recognition of key derived mandibular features that may be useful to assess the relationship among the populations represented at these sites. In order to make an approach to the ecological scenario, we also present a short review and discussion of the archaeological and paleoenvironmental evidences at that time. Our results suggest that probably there was a demographic discontinuity between the late Early Pleistocene populations (MIS 21-MIS 19), and those dated to the MIS 15. Hybridization between residents and new settlers cannot be discarded. However, some features of the Gran Dolina-TD6 hominins point to some relationship between the population represented in this site (probably dated to the MIS 21) and the European Middle Pleistocene and early Late Pleistocene populations. A hypothetical scenario is presented in order to understand this apparent contradiction with the model of discontinuity.

Further study of inversion layer MIS solar cells

NASA Technical Reports Server (NTRS)

Ho, Fat Duen

1992-01-01

Many inversion layer metal-insulator-semiconductor (IL/MIS) solar cells have been fabricated. As of today, the best cell fabricated by us has a 9.138 percent AMO efficiency, with FF = 0.641, V(sub OC) = 0.557 V, and I(sub SC) = 26.9 micro A. Efforts made for fabricating an IL/MOS solar cell with reasonable efficiencies are reported. The more accurate control of the thickness of the thin layer of oxide between aluminum and silicon of the MIS contacts has been achieved by using two different process methods. Comparison of these two different thin oxide processings is reported. The effects of annealing time of the sample are discussed. The range of the resistivity of the substrates used in the IL cell fabrication is experimentally estimated. Theoretical study of the MIS contacts under dark conditions is addressed.

AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy

PubMed Central

Kano, Motohiro; Sosulski, Amanda E.; Zhang, LiHua; Saatcioglu, Hatice D.; Wang, Dan; Nagykery, Nicholas; Sabatini, Mary E.; Gao, Guangping; Donahoe, Patricia K.; Pépin, David

2017-01-01

The ovarian reserve represents the stock of quiescent primordial follicles in the ovary which is gradually depleted during a woman’s reproductive lifespan, resulting in menopause. Müllerian inhibiting substance (MIS) (or anti-Müllerian hormone/AMH), which is produced by granulosa cells of growing follicles, has been proposed as a negative regulator of primordial follicle activation. Here we show that long-term parenteral administration of superphysiological doses of MIS, using either an adeno-associated virus serotype 9 (AAV9) gene therapy vector or recombinant protein, resulted in a complete arrest of folliculogenesis in mice. The ovaries of MIS-treated mice were smaller than those in controls and did not contain growing follicles but retained a normal ovarian reserve. When mice treated with AAV9/MIS were paired with male breeders, they exhibited complete and permanent contraception for their entire reproductive lifespan, disrupted vaginal cycling, and hypergonadotropic hypogonadism. However, when ovaries from AAV9-MIS–treated mice were transplanted orthotopically into normal recipient mice, or when treatment with the protein was discontinued, folliculogenesis resumed, suggesting reversibility. One of the important causes of primary ovarian insufficiency is chemotherapy-induced primordial follicle depletion, which has been proposed to be mediated in part by increased activation. To test the hypothesis that MIS could prevent chemotherapy-induced overactivation, mice were given carboplatin, doxorubicin, or cyclophosphamide and were cotreated with AAV9-MIS, recombinant MIS protein, or vehicle controls. We found significantly more primordial follicles in MIS-treated animals than in controls. Thus treatment with MIS may provide a method of contraception with the unique characteristic of blocking primordial follicle activation that could be exploited to prevent the primary ovarian insufficiency often associated with chemotherapy. PMID:28137855

Electrical properties of MIS devices on CdZnTe/HgCdTe

NASA Astrophysics Data System (ADS)

Lee, Tae-Seok; Jeoung, Y. T.; Kim, Hyun Kyu; Kim, Jae Mook; Song, Jinhan; Ann, S. Y.; Lee, Ji Y.; Kim, Young Hun; Kim, Sun-Ung; Park, Mann-Jang; Lee, S. D.; Suh, Sang-Hee

1998-10-01

In this paper, we report the capacitance-voltage (C-V) properties of metal-insulator-semiconductor (MIS) devices on CdTe/HgCdTe by the metalorganic chemical vapor deposition (MOCVD) and CdZnTe/HgCdTe by thermal evaporation. In MOCVD, CdTe layers are directly grown on HgCdTe using the metal organic sources of DMCd and DiPTe. HgCdTe layers are converted to n-type and the carrier concentration, ND is low 1015 cm-3 after Hg-vacancy annealing at 260 degrees Celsius. In thermal evaporation, CdZnTe passivation layers were deposited on HgCdTe surfaces after the surfaces were etched with 0.5 - 2.0% bromine in methanol solution. To investigate the electrical properties of the MIS devices, the C-V measurement is conducted at 80 K and 1 MHz. C-V curve of MIS devices on CdTe/HgCdTe by MOCVD has shown nearly flat band condition and large hysteresis, which is inferred to result from many defects in CdTe layer induced during Hg-vacancy annealing process. A negative flat band voltage (VFB approximately equals -2 V) and a small hysteresis have been observed for MIS devices on CdZnTe/HgCdTe by thermal evaporation. It is inferred that the negative flat band voltage results from residual Te4+ on the surface after etching with bromine in methanol solution.

Artemisinin resistance containment project in Thailand. (I): Implementation of electronic-based malaria information system for early case detection and individual case management in provinces along the Thai-Cambodian border.

PubMed

Khamsiriwatchara, Amnat; Sudathip, Prayuth; Sawang, Surasak; Vijakadge, Saowanit; Potithavoranan, Thanapon; Sangvichean, Aumnuyphan; Satimai, Wichai; Delacollette, Charles; Singhasivanon, Pratap; Lawpoolsri, Saranath; Kaewkungwal, Jaranit

2012-07-29

The Bureau of Vector-borne Diseases, Ministry of Public Health, Thailand, has implemented an electronic Malaria Information System (eMIS) as part of a strategy to contain artemisinin resistance. The attempt corresponds to the WHO initiative, funded by the Bill & Melinda Gates Foundation, to contain anti-malarial drug resistance in Southeast Asia. The main objective of this study was to demonstrate the eMIS' functionality and outputs after implementation for use in the Thailand artemisinin-resistance containment project. The eMIS had been functioning since 2009 in seven Thai-Cambodian border provinces. The eMIS has covered 61 malaria posts/clinics, 27 Vector-borne Disease Units covering 12,508 hamlets at risk of malaria infections. The eMIS was designed as an evidence-based and near real-time system to capture data for early case detection, intensive case investigation, monitoring drug compliance and on/off-site tracking of malarial patients, as well as collecting data indicating potential drug resistance among patients. Data captured by the eMIS in 2008-2011 were extracted and presented. The core functionalities of the eMIS have been utilized by malaria staff at all levels, from local operational units to ministerial management. The eMIS case detection module suggested decreasing trends during 2009-2011; the number of malaria cases detected in the project areas over the years studied were 3818, 2695, and 2566, with sero-positive rates of 1.24, 0.98, and 1.16%, respectively. The eMIS case investigation module revealed different trends in weekly Plasmodium falciparum case numbers, when classified by responsible operational unit, local and migrant status, and case-detection type. It was shown that most Thai patients were infected within their own residential district, while migrants were infected either at their working village or from across the border. The data mapped in the system suggested that P. falciparum-infected cases and potential drug-resistant cases were

Vegetation and climate history in arid western China during MIS2: New insights from pollen and grain-size data of the Balikun Lake, eastern Tien Shan

NASA Astrophysics Data System (ADS)

Zhao, Yongtao; An, Cheng-Bang; Mao, Limi; Zhao, Jiaju; Tang, Lingyu; Zhou, Aifeng; Li, Hu; Dong, Weimiao; Duan, Futao; Chen, Fahu

2015-10-01

Marine Isotope Stage (MIS) 2 is mostly a cold period encompassing the Last Glacial Maximum (LGM), but the regional expression of MIS2 in arid areas of China is not well known. In this paper, we use high-resolution lacustrine pollen and grain-size records from Balikun Lake to infer vegetation, lake evolution, and climate in arid western China during MIS2. Our results suggest that: 1) the regional vegetation around Balikun was mainly dominated by desert and/or desert-steppe, and Balikun Lake was relatively shallow and experienced high aeolian input during MIS2; 2) distinctive runoff from mountain glacial meltwater in the eastern parts of the Balikun basin caused a high relative abundance of Artemisia pollen during the LGM (26.5-19.2 cal kyr BP), while simultaneously the desert areas expanded as indicated by the high abundance of desert shrubs (e.g., Elaeagnaceae, Rhamnaceae, Hippophae). This cold and dry LGM climate triggered a substantial lowering of lake level; 3) an extremely cold and dry climate prevailing from 17.0 to 15.2 cal kyr BP, correlated with Heinrich event 1 (H1), would explain the low vegetation cover found then; and 4) the warm and humid Bølling/Allerød interstadial (BA: ca. 15-ca. 13 cal kyr BP) is clearly recorded in the Balikun region by the development of wetland herb communities (e.g., Poaceae, Cyperaceae, Typha), and the lake level rose due to increased runoff. Our results challenge the traditional view of cold and wet climatic conditions and high lake levels in arid western China during the LGM, and we propose that changes in local temperature modulated by July insolation was an indispensable factor in triggering vegetation evolution in the Balikun region during MIS2.

The sea-level highstand correlated to marine isotope stage (MIS) 7 in the coastal plain of the state of Rio Grande do Sul, Brazil.

PubMed

Lopes, Renato P; Dillenburg, Sergio R; Schultz, Cesar L; Ferigolo, Jorge; Ribeiro, Ana Maria; Pereira, Jamil C; Holanda, Elizete C; Pitana, Vanessa G; Kerber, Leonardo

2014-12-01

The coastal plain of the state of Rio Grande do Sul, in southern Brazil, includes four barrier-lagoon depositional systems formed by successive Quaternary sea-level highstands that were correlated to marine isotope stages (MIS) 11, 9, 5 and 1, despite the scarcity of absolute ages. This study describes a sea-level highstand older than MIS 5, based on the stratigraphy, ages and fossils of the shallow marine facies found in coastal barrier (Barrier II). This facies outcrops along the banks of Chuí Creek, it is composed of fine, well-sorted quartz sand and contains ichnofossils Ophiomorpha nodosa and Rosselia sp., and molluscan shells. The sedimentary record indicates coastal aggradation followed by sea-level fall and progradation of the coastline. Thermoluminescence (TL) and electron spin resonance (ESR) ages from sediments and fossil shells point to an age of ∼220 ka for the end of this marine transgression, thus correlating it to MIS 7 (substage 7e). Altimetric data point to a maximum amplitude of about 10 meters above present-day mean sea-level, but tectonic processes may be involved. Paleoceanographic conditions at the time of the highstand and correlations with other deposits in the Brazilian coasts are also discussed.

The sea-level highstand correlated to marine isotope stage (MIS) 7 in the coastal plain of the state of Rio Grande do Sul, Brazil.

PubMed

Lopes, Renato P; Dillenburg, Sergio R; Schultz, Cesar L; Ferigolo, Jorge; Ribeiro, Ana Maria; Pereira, Jamil C; Holanda, Elizete C; Pitana, Vanessa G; Kerber, Leonardo

2014-12-09

The coastal plain of the state of Rio Grande do Sul, in southern Brazil, includes four barrier-lagoon depositional systems formed by successive Quaternary sea-level highstands that were correlated to marine isotope stages (MIS) 11, 9, 5 and 1, despite the scarcity of absolute ages. This study describes a sea-level highstand older than MIS 5, based on the stratigraphy, ages and fossils of the shallow marine facies found in coastal barrier (Barrier II). This facies outcrops along the banks of Chuí Creek, it is composed of fine, well-sorted quartz sand and contains ichnofossils Ophiomorpha nodosa and Rosselia sp., and molluscan shells. The sedimentary record indicates coastal aggradation followed by sea-level fall and progradation of the coastline. Thermoluminescence (TL) and electron spin resonance (ESR) ages from sediments and fossil shells point to an age of ∼220 ka for the end of this marine transgression, thus correlating it to MIS 7 (substage 7e). Altimetric data point to a maximum amplitude of about 10 meters above present-day mean sea-level, but tectonic processes may be involved. Paleoceanographic conditions at the time of the highstand and correlations with other deposits in the Brazilian coasts are also discussed.

Space Station Furnace Facility Management Information System (SSFF-MIS) Development

NASA Technical Reports Server (NTRS)

Mead, Robert M.

1996-01-01

Thios report summarizes the chronology, results, and lessons learned from the development of the SSFF-MIS. This system has been nearly two years in development and has yielded some valuable insights into specialized MIS development. Attachment A contains additions, corrections, and deletions by the COTR.

SAGES's advanced GI/MIS fellowship curriculum pilot project.

PubMed

Weis, Joshua J; Goldblatt, Matthew; Pryor, Aurora; Dunkin, Brian J; Brunt, L Michael; Jones, Daniel B; Scott, Daniel J

2018-06-01

The American health care system faces deficits in quality and quantity of surgeons. SAGES is a major stakeholder in surgical fellowship training and is responsible for defining the curriculum for the Advanced GI/MIS fellowship. SAGES leadership is actively adapting this curriculum. The process of reform began in 2014 through a series of iterative meetings and discussions. A working group within the Resident and Fellow Training Committee reviewed case log data from 2012 to 2015. These data were used to propose new criteria designed to provide adequate exposure to core content. The working group also proposed using video assessment of an MIS case to provide objective assessment of competency. Case log data were available for 326 fellows with a total of 85,154 cases logged (median 227 per fellow). The working group proposed new criteria starting with minimum case volumes for five defined categories including foregut (20), bariatrics (25), inguinal hernia (10), ventral hernia (10), and solid organ/colon/thoracic (10). Fellows are expected to perform an additional 75 complex MIS cases of any category for a total of 150 required cases overall. The proposal also included a minimum volume of flexible endoscopy (50) and submission of an MIS foregut case for video assessment. The new criteria more clearly defined which surgeon roles count for major credit within individual categories. Fourteen fellowships volunteered to pilot these new criteria for the 2017-2018 academic year. The new SAGES Advanced GI/MIS fellowship has been crafted to better define the core content that should be contained in these fellowships, while still allowing sufficient heterogeneity so that individual learners can tailor their training to specific areas of interest. The criteria also introduce innovative, evidence-based methods for assessing competency. Pending the results of the pilot program, SAGES will consider broad implementation of the new fellowship criteria.

Integrating Intellectual Property Concepts into MIS Education: An Empirical Assessment

ERIC Educational Resources Information Center

Mykytyn, Peter P., Jr.; Mykytyn, Kathleen; Harrison, David A.

2005-01-01

The evolving legal environment surrounding intellectual property (IP) and its impact on information systems, especially involving electronic commerce, and the type of education and training provided by management information systems (MIS) faculty to MIS students is a relationship that has not been investigated. Although organizations are…

Perceived Requirements of MIS Curriculum Implementation in Bilingual Developing Countries

ERIC Educational Resources Information Center

Kabeil, Magdy M.

2005-01-01

This paper addresses additional requirements associated with implementing a standard curriculum of Management Information Systems (MIS) in bilingual developing countries where both students and workplace users speak English as a second language. In such countries, MIS graduates are required to develop bilingual computer applications and to…

Efficient III-Nitride MIS-HEMT devices with high-κ gate dielectric for high-power switching boost converter circuits

NASA Astrophysics Data System (ADS)

Mohanbabu, A.; Mohankumar, N.; Godwin Raj, D.; Sarkar, Partha; Saha, Samar K.

2017-03-01

The paper reports the results of a systematic theoretical study on efficient recessed-gate, double-heterostructure, and normally-OFF metal-insulator-semiconductor high-electron mobility transistors (MIS-HEMTs), HfAlOx/AlGaN on Al2O3 substrate. In device architecture, a thin AlGaN layer is used in the AlGaN graded barrier MIS-HEMTs that offers an excellent enhancement-mode device operation with threshold voltage higher than 5.3 V and drain current above 0.64 A/mm along with high on-current/off-current ratio over 107 and subthreshold slope less than 73 mV/dec. In addition, a high OFF-state breakdown voltage of 1200 V is achieved for a device with a gate-to-drain distance and field-plate length of 15 μm and 5.3 μm, respectively at a drain current of 1 mA/mm with a zero gate bias, and the substrate grounded. The numerical device simulation results show that in comparison to a conventional AlGaN/GaN MIS-HEMT of similar design, a graded barrier MIS-HEMT device exhibits a better interface property, remarkable suppression of leakage current, and a significant improvement of breakdown voltage for HfAlOx gate dielectric. Finally, the benefit of HfAlOx graded-barrier AlGaN MIS-HEMTs based switching devices is evaluated on an ultra-low-loss converter circuit.

Studies of Large-Area Inversion-Layer Metal-Insulator-Semiconductor (IL/MIS) Solar Cells and Arrays

NASA Technical Reports Server (NTRS)

Ho, Fat Duen

1996-01-01

Many inversion-layer metal-insulator-semiconductor (IL/MIS) solar cells have been fabricated. There are around eighteen 1 cm(exp 2) IL/MIS solar cells which have efficiencies greater than 7%. There are only about three 19 cm(exp 2) IL/MIS cells which have efficiencies greater than 4%. The more accurate control of the thickness of the thin layer of oxide between aluminum and silicon of the MIS contacts has been achieved. A lot of effort and progress have been made in this area. A comprehensive model for MIS contacts under dark conditions has been developed that covers a wide range of parameters. It has been applied to MIS solar cells. One of the main advantages of these models is the prediction of the range of the thin oxide thickness versus the maximum efficiencies of the MIS solar cells. This is particularly important when the thickness is increased to 25 A. This study is very useful for our investigation of the IL/MIS solar cells. The two-dimensional numerical model for the IL/MIS solar cells has been tried to develop and the results are presented in this report.

Marine Isotope Stage (MIS) M2 ( 3.3 Ma) in the southern hemisphere: constraining the climatic drivers of a short-term glaciation event during the Pliocene warm Period.

NASA Astrophysics Data System (ADS)

De Vleeschouwer, D.; Auer, G.; Bogus, K.; Groeneveld, J.; Henderiks, J.; Jatiningrum, R. S.; Christensen, B. A.

2017-12-01

Global climate was characterized by intriguing climate variability during the Late Pliocene (3.6 to 2.59 Ma): a brief (<100 kyr) but intense glaciation (MIS M2) interrupted the relatively warm climate state around 3.3 Ma. Until today, different hypotheses exist to explain why this glaciation event was so intense, and why the global climate system returned to warm Pliocene conditions relatively quickly. One of these proposed mechanisms is a reduced equator-to-pole heat transfer, in response to a tectonically reduced Indonesian Throughflow (ITF; De Schepper et al., 2014; Karas et al., 2011a, b). However, the scarcity of orbital-scale continuous climate archives in the outflow of the Indonesian Seaway hampers testing this hypothesis. To assess the supposed relationship between mid-Pliocene glaciations and latitudinal heat transport through the Indonesian Throughflow, we constructed a 3-kyr resolution planktonic δ18OG.sacculiferrecord for the 3.9 - 2.7 Ma interval from Site U1463 (18°59'S, 117°37'E; Northwestern Australian Shelf; IODP Expedition 356 "Indonesian Throughflow"). The U1463 oxygen isotope record concurs exceptionally well with the sea surface temperature (SST) record from Site 806 (0°19'N, 159°22'E) in the West Pacific Warm Pool (Wara et al., 2005), even during MIS M2. Hence, Site U1463 suggests an uninterrupted ITF signal during Pliocene glaciations. Surprisingly though, the U1463 δ18OG.sacculifer record exhibits a 0.5‰ offset with the nearby Site 763 record (20°35'S, 112°12'E) around MIS M2. This implies that Site 763, which lies a bit further offshore than U1463, fits better with Indian Ocean SST records (e.g. Site 214; Karas et al., 2009) across MIS M2. In conclusion, the U1463 data reveal that heat-transport through the Indonesian Throughflow did not shut down completely during MIS M2. However, its intensity decreased during MIS M2, causing Site 763 to temporarily reflect an Indian Ocean, rather than an ITF signal. References De Schepper, S

MIS Development in Higher Education: A Framework for Systems Planning.

ERIC Educational Resources Information Center

St. John, Edward P.

An institutional management systems development study examined the Management Information Systems (MIS) needs of 23 public institutions of higher education in Missouri. The result was a model framework for other institutions to develop MIS appropriate to their needs. One of five distinct structural development phases could be related to all…

Dead Sea drawdown and monsoonal impacts in the Levant during the last interglacial

NASA Astrophysics Data System (ADS)

Torfstein, Adi; Goldstein, Steven L.; Kushnir, Yochanan; Enzel, Yehouda; Haug, Gerald; Stein, Mordechai

2015-02-01

Sediment cores recovered by the Dead Sea Deep Drilling Project (DSDDP) from the deepest basin of the hypersaline, terminal Dead Sea (lake floor at ∼725 m below mean sea level) reveal the detailed climate history of the lake's watershed during the last interglacial period (Marine Isotope Stage 5; MIS5). The results document both a more intense aridity during MIS5 than during the Holocene, and the moderating impacts derived from the intense MIS5e African Monsoon. Early MIS5e (∼133-128 ka) was dominated by hyperarid conditions in the Eastern Mediterranean-Levant, indicated by thick halite deposition triggered by a lake-level drop. Halite deposition was interrupted however, during the MIS5e peak (∼128-122 ka) by sequences of flood deposits, which are coeval with the timing of the intense precession-forced African monsoon that generated Mediterranean sapropel S5. A subsequent weakening of this humidity source triggered extreme aridity in the Dead Sea watershed and resulting in the biggest known lake level drawdown in its history, reflected by the deposition of thick salt layers, and a capping pebble layer corresponding to a hiatus at ∼116-110 ka. The DSDDP core provides the first evidence for a direct association of the African monsoon with mid subtropical latitude climate systems effecting the Dead Sea watershed. Combined with coeval deposition of Arabia and southern Negev speleothems, Arava travertines, and calcification of Red Sea corals, the evidence points to a climatically wet corridor that could have facilitated homo sapiens migration "out of Africa" during the MIS5e peak. The hyperaridity documented during MIS5e may provide an important analogue for future warming of arid regions of the Eastern Mediterranean-Levant.

Noise characterization of enhancement-mode AlGaN graded barrier MIS-HEMT devices

NASA Astrophysics Data System (ADS)

Mohanbabu, A.; Saravana Kumar, R.; Mohankumar, N.

2017-12-01

This paper reports a systematic theoretical study on the microwave noise performance of graded AlGaN/GaN metal-insulator semiconductor high-electron mobility transistors (MIS-HEMTs) built on an Al2O3 substrate. The HfAlOx/AlGaN/GaN MIS-HEMT devices designed for this study show an outstanding small signal analog/RF and noise performance. The results on 1 μm gate length device show an enhancement mode operation with threshold voltage, VT = + 5.3 V, low drain leakage current, Ids,LL in the order of 1 × 10-9 A/mm along with high current gain cut-off frequency, fT of 17 GHz and maximum oscillation frequency fmax of 47 GHz at Vds = 10 V. The device Isbnd V and low-frequency noise estimation of the gate and drain noise spectral density and their correlation are evaluated using a Green's function method under different biasing conditions. The devices show a minimum noise figure (NFmin) of 1.053 dB in combination with equivalent noise resistance (Rn) of 23 Ω at 17 GHz, at Vgs = 6 V and Vds = 5 V which is relatively low and is suitable for broad-band low-noise amplifiers. This study shows that the graded AlGaN MIS-HEMT with HfAlOX gate insulator is appropriate for application requiring high-power and low-noise.

Links between Patagonian Ice Sheet fluctuations and Antarctic dust variability during the last glacial period (MIS 4-2)

NASA Astrophysics Data System (ADS)

Kaiser, Jérôme; Lamy, Frank

2010-06-01

Antarctic and Greenland ice-core records reveal large fluctuations of dust input on both orbital and millennial time-scales with potential global climate implications. At least during glacial periods, the Antarctic dust fluctuations appear to be largely controlled by environmental changes in southern South America. We compare dust flux records from two Antarctic ice-cores to variations in the composition of the terrigenous supply at ODP Site 1233 located off southern Chile and known to record fluctuations in the extent of the northern part of the Patagonian ice-sheet (NPIS) during the last glacial period (Marine Isotope Stage, MIS, 4 to 2). Within age uncertainties, millennial-scale glacial advances (retreats) of the NPIS correlate to Antarctic dust maxima (minima). In turn, NPIS fluctuations were closely related to offshore sea surface temperature (SST) changes. This pattern suggests a causal link involving changes in temperature, in rock flour availability, in latitudinal extensions of the westerly winds and in foehn winds in the southern Pampas and Patagonia. We further suggest that the long-term trend of dust accumulation is partly linked to the sea-level related changes in the size if the Patagonian source area due to the particular morphology of the Argentine shelf. We suggest that sea-level drops at the beginning of MIS 4 and MIS 2 were important for long-term dust increases, while changes in the Patagonian dust source regions primarily control the early dust decrease during the MIS 4/3 transition and Termination 1.

Material-induced Senescence (MIS): Fluidity Induces Senescent Type Cell Death of Lung Cancer Cells via Insulin-Like Growth Factor Binding Protein 5.

PubMed

Mano, Sharmy Saimon; Uto, Koichiro; Ebara, Mitsuhiro

2017-01-01

Objective: We propose here material-induced senescence (MIS) as a new therapeutic concept that limits cancer progression by stable cell cycle arrest. This study examined for the first time the effect of material fluidity on cellular senescence in lung carcinoma using poly(ε-caprolactone- co -D, L-lactide) (P(CL- co -DLLA)) with tunable elasticity and fluidity. Methods: The fluidity was varied by chemically crosslinking the polymer networks: the crosslinked P(CL- co -DLLA) shows solid-like properties with a stiffness of 260 kPa, while the non-crosslinked polymer exists in a quasi-liquid state with loss and storage moduli of 33 kPa and 11 kPa, respectively. Results: We found that cancer cells growing on the non-crosslinked, fluidic substrate undergo a non-apoptotic form of cell death and the cell cycle was accumulated in a G0/G1 phase. Next, we investigated the expression of biomarkers that are associated with cancer pathways. The cancer cells on the fluidic substrate expressed several biomarkers associated with senescence such as insulin-like growth factor binding protein 5 (IGFBP5). This result indicates that when cancer cells sense fluidity in their surroundings, the cells express IGFBP5, which in turn triggers the expression of tumor suppressor protein 53 and initiates cell cycle arrest at the G1 phase followed by cellular senescence. Furthermore, the cancer cells on the fluidic substrate maintained their epithelial phenotype, suggesting that the cancer cells do not undergo epithelial to mesenchymal transition. Conclusion: By considering these results as the fundamental information for MIS, our system could be applied to induce senescence in treatment-resistant cancers such as metastatic cancer or cancer stem cells.

Exposure dating and glacial reconstruction at Mt. Field, Tasmania, Australia, identifies MIS 3 and MIS 2 glacial advances and climatic variability

NASA Astrophysics Data System (ADS)

Mackintosh, A. N.; Barrows, T. T.; Colhoun, E. A.; Fifield, L. K.

2006-05-01

Tasmania is important for understanding Quaternary climatic change because it is one of only three areas that experienced extensive mid-latitude Southern Hemisphere glaciation and it lies in a dominantly oceanic environment at a great distance from Northern Hemisphere ice sheet feedbacks. We applied exposure dating using 36Cl to an extensive sequence of moraines from the last glacial at Mt. Field, Tasmania. Glaciers advanced at 41-44 ka during Marine oxygen Isotope Stage (MIS) 3 and at 18 ka during MIS 2. Both advances occurred in response to an ELA lowering greater than 1100 m below the present-day mean summer freezing level, and a possible temperature reduction of 7-8°C. Deglaciation was rapid and complete by ca. 16 ka. The overall story emerging from studies of former Tasmanian glaciers is that the MIS 2 glaciation was of limited extent and that some glaciers were more extensive during earlier parts of the last glacial cycle. Copyright

Climate variability and volcanic history of the Eastern Romanian Carpathians since early MIS 3 recorded in sediments from Mohoş crater

NASA Astrophysics Data System (ADS)

Bormann, M.; Veres, D.; Wulf, S.; Papadopoulou, M.; Panagiotopoulos, K.; Schaebitz, F.

2015-12-01

We present a 30m long sediment record covering the last ca. 50,000 years from the in-filled Mohoş crater (46°05' N; 25°55' E) located on Ciomadul volcano (Romania) that was retrieved in 2014. The record consists of bog and lacustrine sediments that are inter-bedded with tephra deposits. Ciomadul volcano, hosting the superimposed craters of Mohoş and Sf. Ana, is the youngest volcanic edifice in the Carpathian-Balkan region. Thus, tephra-analysis on the Mohoş sediments gives valuable insights into the volcanic history of that region, mainly arising from the younger crater of Sf Ana and several secondary domes. For investigations into the past climate history, the Mohoş sediment sequence has been analysed using a multi-proxy approach including geophysical, geochemical and sedimentological parameters. Multi-Sensor core logging and ITRAX X-ray fluorescence scanning have been performed at high-resolution, whereas grain size analysis, TOC and C/N ratios supplement the geophysical and geochemical data. Chronological control is based on radiocarbon and luminescence dating. We also present first results of the tephra-analysis on the Mohoş sediment record and their correlation to medium-distal pyroclastic deposits originating in this volcanic field. We further discuss responses of this mid-altitude site (1050 m a.s.l.) to past climate oscillations since early MIS 3. To date, the Mohoş core record provides the longest time series from the Carpathian region. This study is part of the Collaborative Research Centre 806 "Our Way To Europe; Culture-Environment Interaction and Human Mobility in the Late Quaternary" (www.sfb806.de); subproject B2.

[Mutations of amyloid precursor protein in early-onset familial Alzheimer's disease].

PubMed

Naruse, S; Tsuji, S; Miyatake, T

1992-09-01

Genetic linkage studies of familial Alzheimer's disease (FAD) have suggested that some form of early-onset FAD is linked to proximal long arm of chromosome 21. It has been also suggested that some form of late-onset FAD is linked to long arm of chromosome 19. Goate et al have identified a mis-sense mutation (Val to Ile) in exon 17 of the amyloid precursor protein (APP) gene in 2 of 16 early-onset FAD families, and have shown that the FAD locus in an FAD family is tightly linked to the mis-sense mutation. To determine if the mis-sense mutation is observed in different ethnic origine, we have studied some early-onset FAD families. Two early-onset FAD families showed the existence of the mutation. As the mutation has been identified in different ethnic origine and the mutation has not been observed in normal individuals, it strengthen hypothesis that the mutation is pathogenic. Recently, Val to Phe and Val to Gly mutations have been also identified at the same codon (Codon 717) of the APP gene.

Minimally Invasive Direct Lateral Interbody Fusion (MIS-DLIF): Proof of Concept and Perioperative Results.

PubMed

Abbasi, Hamid; Abbasi, Ali

2017-01-14

Minimally invasive direct lateral interbody fusion (MIS-DLIF) is a novel approach for fusions of the lumbar spine. In this proof of concept study, we describe the surgical technique and report our experience and the perioperative outcomes of the first nine patients who underwent this procedure. In this study we establish the safety and efficacy of this approach. MIS-DLIF was performed on 15 spinal levels in nine patients who failed to respond to conservative therapy for the treatment of a re-herniated disk, spondylolisthesis, or other severe disk disease of the lumbar spine. We recorded surgery time, blood loss, fluoroscopy time, patient-reported pain, and complications. Throughout the MIS-DLIF procedure, the surgeon is aided by biplanar fluoroscopic imaging to place an interbody graft or cage into the disc space through the interpleural space. A discectomy is performed in the same minimally invasive fashion. The procedure is usually completed with posterior pedicle screw fixation. MIS-DLIF took 44/85 minutes, on average, for 1/2 levels, with 54/112 ml of blood loss, and 0.3/1.7 days of hospital stay. Four of nine patients did not require overnight hospitalization and were discharged two to four hours after surgery. We did not encounter any clinically significant complications. At more than ninety days post surgery, the patients reported a statistically significant reduction of 4.5 points on a 10-point sliding pain scale. MIS-DLIF with pedicle screw fixation is a safe and clinically effective procedure for fusions of the lumbar spine. The procedure overcomes many of the limitations of the current minimally invasive approaches to the lumbar spine and is technically straightforward. MIS-DLIF has the potential to improve patient outcomes and reduce costs relative to the current standard of care and therefore warrants further investigation. We are currently expanding this study to a larger cohort and documenting long-term outcome data.

Implications of Nubian-Like Core Reduction Systems in Southern Africa for the Identification of Early Modern Human Dispersals

PubMed Central

Phillips, Natasha

2015-01-01

Lithic technologies have been used to trace dispersals of early human populations within and beyond Africa. Convergence in lithic systems has the potential to confound such interpretations, implying connections between unrelated groups. Due to their reductive nature, stone artefacts are unusually prone to this chance appearance of similar forms in unrelated populations. Here we present data from the South African Middle Stone Age sites Uitpanskraal 7 and Mertenhof suggesting that Nubian core reduction systems associated with Late Pleistocene populations in North Africa and potentially with early human migrations out of Africa in MIS 5 also occur in southern Africa during early MIS 3 and with no clear connection to the North African occurrence. The timing and spatial distribution of their appearance in southern and northern Africa implies technological convergence, rather than diffusion or dispersal. While lithic technologies can be a critical guide to human population flux, their utility in tracing early human dispersals at large spatial and temporal scales with stone artefact types remains questionable. PMID:26125972

Training for an MIS Implementation: What Does it Really Cost?

PubMed Central

Jacobs, Patt

1984-01-01

Implementation of MIS systems in a hospital environment are complex, problematic, long-term endeavors. St. Vincent Hospital and Medical Center (SVHMC) completed the implementation of its base system MIS five years after the original contract was signed. The cost of that implementation in terms of time and dollars for one aspect only, training is reported.

Electrical and carrier transport properties of the Au/Y2O3/n-GaN metal-insulator-semiconductor (MIS) diode with rare-earth oxide interlayer

NASA Astrophysics Data System (ADS)

Venkata Prasad, C.; Rajagopal Reddy, V.; Choi, Chel-Jong

2017-04-01

The electrical and transport properties of rare-earth Y2O3 on n-type GaN with Au electrode have been investigated by current-voltage and capacitance-voltage techniques at room temperature. The Au/Y2O3/n-GaN metal-insulator-semiconductor (MIS) diode shows a good rectification behavior compared to the Au/n-GaN metal-semiconductor (MS) diode. Statistical analysis showed that a mean barrier height (BH) and ideality factor are 0.78 eV and 1.93, and 0.96 eV and 2.09 for the Au/n-GaN MS and Au/Y2O3/n-GaN MIS diodes, respectively. Results indicate that the high BH is obtained for the MIS diode compared to the MS diode. The BH, ideality factor and series resistance are also estimated by Cheung's function and Norde method. From the forward current-voltage data, the interface state density ( N SS) is estimated for both the MS and MIS Schottky diodes, and found that the estimated N SS is lower for the MIS diode compared to the MS diode. The results reveal that the introduction of Y2O3 interlayer facilitated the reduction of N SS of the Au/n-GaN interface. Experimental results suggest that the Poole-Frenkel emission is a dominant conduction mechanism in the reverse bias region of both Au/n-GaN MS and Au/Y2O3/n-GaN MIS diodes.

Mis-Education: A Recurring Theme? Transforming Black Religious and Theological Education

ERIC Educational Resources Information Center

Wright, Almeda M.

2017-01-01

Educating ministers and religious educators with the skills to connect with a variety of congregations and communities is a difficult task. Looking specifically at theological and religious education with African Americans, there are historical criticisms of "mis-education." "Mis-education" defined by Carter G. Woodson…

Subsurface North Atlantic warming as a trigger of rapid cooling events: evidences from the Early Pleistocene (MIS 31-19)

NASA Astrophysics Data System (ADS)

Hernández-Almeida, I.; Sierro, F.-J.; Cacho, I.; Flores, J.-A.

2014-10-01

Subsurface water column dynamics in the subpolar North Atlantic were reconstructed in order to improve the understanding of the cause of abrupt IRD events during cold periods of the Early Pleistocene. We used Mg / Ca-based temperatures of deep-dwelling (Neogloboquadrina pachyderma sinistral) planktonic foraminifera and paired Mg / Ca-δ18O measurements to estimate the subsurface temperatures and δ18O of seawater at Site U1314. Carbon isotopes on benthic and planktonic foraminifera from the same site provide information about the ventilation and water column nutrient gradient. Mg / Ca-based temperatures and δ18O of seawater suggest increased temperatures and salinities during ice-rafting, likely due to enhanced northward subsurface transport of subtropical waters during periods of AMOC reduction. Planktonic carbon isotopes support this suggestion, showing coincident increased subsurface ventilation during deposition of ice-rafted detritus (IRD). Warm waters accumulated at subsurface would result in basal warming and break-up of ice-shelves, leading to massive iceberg discharges in the North Atlantic. Release of heat and salt stored at subsurface would help to restart the AMOC. This mechanism is in agreement with modelling and proxy studies that observe a subsurface warming in the North Atlantic in response to AMOC slowdown during the MIS3.

E2F4 is required for early eye patterning.

PubMed

Ruzhynsky, Vladimir A; Furimsky, Marosh; Park, David S; Wallace, Valerie A; Slack, Ruth S

2009-01-01

Increasingly, studies reveal novel functions for cell cycle proteins during development. Here, we investigated the role of E2F4 in eye development. E2F4-deficient mouse embryos exhibit severe early eye patterning defects, which are evident from embryonic day 11.5 and characterized by aberrant shape of the optic cup, coloboma as well as abnormal eye pigmentation. Loss of E2F4 is associated with proximal-distal patterning defects in the optic vesicle. These defects are characterized by the expansion of optic stalk marker gene expression to the optic cup and reduced expression of ventral optic cup markers. These defects are associated with a split of Shh expression domain at the ventral midline of the forebrain and expansion of the Shh activity into the ventral optic cup. Despite these patterning defects, early neuronal differentiation and Shh expression in the retina are not affected by E2F4 deletion. Overall, the results of our studies show a novel role of E2F4 in the early eye development. 2009 S. Karger AG, Basel.

A new ELSA time series of tephra layers and paleobotanical evidence from laminated Eifel maar sediments covering the entire last 120,000 years

NASA Astrophysics Data System (ADS)

Sirocko, Frank; Knapp, Hannes; Klee, Marlies; Rothacker, Leo; Kromer, Bernd

2014-05-01

The ELSA Project has drilled a total of 50 sediment cores (2000 m of laminated lake sediment) from Eifel maar lakes and dry maar structures during the last 15 years. These records have been dated using 7 different methods, including 370 14C dates. Ten records reveal the established palynological succession of trees during the Holocene down to the Laacher See Tephra, which is used for synchronization with seven more recently drilled laminated sediment cores, which all are 14C-dated too and analyzed for tephra, pollen and paleobotanical macroremains. The seven newly established records reveal a continuous MIS2 section with mosses, ostracods and characea oogonia. They show that the 28.000 - 40.000 BP has witnessed an open landscape dominated by grass, but with rhythmic spread of conifer trees following the Greenland interstadial/succession. Seeds of Ranunculae provide excellent material for 14C dating. Even deciduous trees are present in small amounts until 28.000 BP. The time from 48.000 to 40.000 BP is characterized by a pronounced transition from the open landscape to an early MIS3 spruce (Picea) dominated forest during Greenland Interstadial GI17-14. Modern man apparently arrived at the end of this principal vegetation change near 40,000 BP. Volcanic activity in the Eifel had a stable and pronounced recurrence from 55,000 - 30,000 BP every 4000 years, but commenced with the beginning of MIS2. This landscape evolution with a forested early MIS3 is quite different to peat and sediment records from Netherlands/ Northern Germany/Scandinavia/ Poland, but is similar to conditions in parts of Switzerland. We address the early MIS3 forest to the nearby continuously moist soils and warm conditions in the nearby Mosel valley, i.e. on those stands where wine is growing today, and which most likely had served as a local refugia even for deciduous trees during MIS4 and MIS3. The MIS5 sections of the presented ELSA records reach down at least to the beginning of MIS5d near 118

A Modified Protocol with Improved Detection Rate for Mis-Matched Donor HLA from Low Quantities of DNA in Urine Samples from Kidney Graft Recipients.

PubMed

Kwok, Janette; Choi, Leo C W; Ho, Jenny C Y; Chan, Gavin S W; Mok, Maggie M Y; Lam, Man-Fei; Chak, Wai-Leung; Cheuk, Au; Chau, Ka-Foon; Tong, Matthew; Chan, Kwok-Wah; Chan, Tak-Mao

2016-01-01

Urine from kidney transplant recipient has proven to be a viable source for donor DNA. However, an optimized protocol would be required to determine mis-matched donor HLA specificities in view of the scarcity of DNA obtained in some cases. In this study, fresh early morning urine specimens were obtained from 155 kidney transplant recipients with known donor HLA phenotype. DNA was extracted and typing of HLA-A, B and DRB1 loci by polymerase chain reaction-specific sequence primers was performed using tailor-made condition according to the concentration of extracted DNA. HLA typing of DNA extracted from urine revealed both recipient and donor HLA phenotypes, allowing the deduction of the unknown donor HLA and hence the degree of HLA mis-match. By adopting the modified procedures, mis-matched donor HLA phenotypes were successfully deduced in all of 35 tested urine samples at DNA quantities spanning the range of 620-24,000 ng. This urine-based method offers a promising and reliable non-invasive means for the identification of mis-matched donor HLA antigens in kidney transplant recipients with unknown donor HLA phenotype or otherwise inadequate donor information.

[Quality of data on early neonatal deaths].

PubMed

Pedrosa, Linda Délia Carvalho de Oliveira; Sarinho, Silvia Wanick; Ximenes, Ricardo Arraes de Alencar; Ordonha, Manoelina R

2007-01-01

To investigate the quality of official neonatal death data in Maceió, Alagoas. A descriptive study was conducted on early neonatal deaths in hospitals between January 1, 2001, and December 31, 2002, to compare data entry in the Death Certificate (DC) and Mortality Information System (MIS) with a standardized form filled out with data of medical files from the mothers and newborn. The frequency with which the following variables failed to be recorded in the DC and SIM was studied: type of death, address, age of mother, gender, birth weight, and delivery type, age at death and gestational age. MIS reliability was verified using simple concordance, sensitivity and Kappa indicator. MIS recorded 451 deaths, of which 50 were excluded. Mother's age was omitted from MIS in 44.1% of cases. 85.7% to 100% of the variables not filled in for the DC were recovered from the medical files. There was good concordance between DC and medical files for type of delivery, weight and age. Birth weight and age of mother presented the least concordance between medical files and MIS. MIS presented 69.2% sensitivity for weight and 36.3% for age of mother, thus demonstrating little capability to correctly supply information to generate perinatal health indicators. Because of incomplete filling out, quality of the DC becomes precarious and makes the MIS inadequate, even though it covers 100% of neonatal deaths in Maceió. Inefficiency of the system is increased by failure of MIS technicians to correct errors found and input all the information available.

Iceberg and meltwater discharge events in the western Arctic Ocean since MIS 5: a comparison of sediment cores off the East Siberian and Chukchi margins

NASA Astrophysics Data System (ADS)

Xiao, W.; Wang, R.; Zhang, T.; Duan, X.; Polyak, L.

2017-12-01

In the Pleistocene the western Arctic Ocean was affected by deglacial discharge events from ice sheets in northern North America as well as the East Siberian and Chukchi margins. Distribution of Ice Rafted Debris (IRD) >250 μm and planktonic foraminiferal N. pachyderma (sin.) (Nps) δ18O and δ13C was compared in CHINARE sediment cores ARC2-M03 (Wang et al., 2013) and ARC3-P37 from the Chukchi Abyssal Plain and Northwind Ridge, respectively, to identify the impacts of icebergs and meltwater on paleoceanographic environments since MIS 5. The IRD is mainly composed of quartz grains and fragments of clastic rocks and detrital carbonates. The carbonates, mostly dolomites characteristic of the Canadian Arctic Archipelago (CAA) provenance, typically anti-correlate with quartz and clastic rocks, indicating different sources such as Chukchi-Alaskan or East Siberian margin. Most of the Nps δ18O depletions correspond to peaks in detrital carbonates, suggesting a strong influence of meltwater from the Laurentide Ice Sheet (LIS) on the western Arctic Ocean. A conspicuous dark gray interval interpreted to represent glacial/deglacial environments of MIS 4/3 age, shows a remarkable depletion in Nps δ13C along with high δ18O values and absence of IRD. This unusual signature may be related to a persistent sea-ice cover and/or high fluxes of terrigenous material with deglacial debris flows. In a younger grey interval corresponding to MIS2, high abundances of quartz and clastic rocks in the Northwind Ridge core ARC3-P37 indicate iceberg discharge from areas other than CAA, such as the Mackenzie LIS lobe or Chukchi-Alaskan margin. The MIS2-Holocene transition is marked by an increase in detrital carbonates co-occurring with Nps δ13C and δ18O depletion (Polyak et al., 2007), indicative of LIS iceberg/meltwater fluxes from the CAA. We note that stable-isotope events in the study area may go unnoticed because of gaps in foraminiferal records related to dissolution and/or adverse

Temperature dependent electrical characterisation of Pt/HfO{sub 2}/n-GaN metal-insulator-semiconductor (MIS) Schottky diodes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shetty, Arjun, E-mail: arjun@ece.iisc.ernet.in; Vinoy, K. J.; Roul, Basanta

2015-09-15

This paper reports an improvement in Pt/n-GaN metal-semiconductor (MS) Schottky diode characteristics by the introduction of a layer of HfO{sub 2} (5 nm) between the metal and semiconductor interface. The resulting Pt/HfO{sub 2}/n-GaN metal-insulator-semiconductor (MIS) Schottky diode showed an increase in rectification ratio from 35.9 to 98.9(@ 2V), increase in barrier height (0.52 eV to 0.63eV) and a reduction in ideality factor (2.1 to 1.3) as compared to the MS Schottky. Epitaxial n-type GaN films of thickness 300nm were grown using plasma assisted molecular beam epitaxy (PAMBE). The crystalline and optical qualities of the films were confirmed using high resolutionmore » X-ray diffraction and photoluminescence measurements. Metal-semiconductor (Pt/n-GaN) and metal-insulator-semiconductor (Pt/HfO{sub 2}/n-GaN) Schottky diodes were fabricated. To gain further understanding of the Pt/HfO{sub 2}/GaN interface, I-V characterisation was carried out on the MIS Schottky diode over a temperature range of 150 K to 370 K. The barrier height was found to increase (0.3 eV to 0.79 eV) and the ideality factor decreased (3.6 to 1.2) with increase in temperature from 150 K to 370 K. This temperature dependence was attributed to the inhomogeneous nature of the contact and the explanation was validated by fitting the experimental data into a Gaussian distribution of barrier heights.« less

A case of early Wisconsinan ;over-chill;: New radiocarbon evidence for early extirpation of western camel (Camelops hesternus) in eastern Beringia

NASA Astrophysics Data System (ADS)

Zazula, Grant D.; MacPhee, Ross D. E.; Southon, John; Nalawade-Chavan, Shweta; Reyes, Alberto V.; Hewitson, Susan; Hall, Elizabeth

2017-09-01

There are comparatively few fossils that document the presence of the Pleistocene western camel (Camelops hesternus) in the unglaciated regions of Alaska and Yukon, northwestern North America (eastern Beringia). It has been previously reported on the basis of stratigraphic and radiocarbon data that this species was present within this region from the Sangamonian interglaciation (Marine Isotope Stage (MIS) 5) through the Last Glacial Maximum (LGM, MIS 2). However, the continued presence of western camel through the LGM is at odds with its ecological preferences as inferred from more southerly parts of the continent. Here we report 43 new radiocarbon dates on 34 western camel fossils from Alaska and Yukon, including specimens that have been dated previously. To minimize exogenous carbon contamination, we utilized either ultrafiltered collagen or single amino acid (hydroxyproline) methodologies in conducting the analyses. All samples, including previously reported specimens with finite ages, yielded ages that were either non-finite or close to the effective limit of radiocarbon dating. These results indicate that dates implying local presence of western camels in Alaska and Yukon during full-glacial conditions of MIS 2 are erroneous by as much as several tens of millennia, probably because of carbon contamination from glue or varnish used in fossil preparation and conservation. The revised radiocarbon chronology, together with other evidence, indicates that western camels were only able to occupy eastern Beringia only during Pleistocene interglaciations such as MIS 5, when forests and shrublands became the dominant regional biomes. The subsequent transition to cold, arid full-glacial conditions during the early Wisconsinan glaciation (MIS 4) around 75 000 years ago created unfavorable environmental conditions, eliminated browse, and led to their local extirpation in eastern Beringia. After their complete population loss in the Arctic and Subarctic, the range of

Evidence for the timing of sea-level events during MIS 3

NASA Astrophysics Data System (ADS)

Siddall, M.

2005-12-01

Four large sea-level peaks of millennial-scale duration occur during MIS 3. In addition smaller peaks may exist close to the sensitivity of existing methods to derive sea level during these periods. Millennial-scale changes in temperature during MIS 3 are well documented across much of the planet and are linked in some unknown, yet fundamental way to changes in ice volume / sea level. It is therefore highly likely that the timing of the sea level events during MIS 3 will prove to be a `Rosetta Stone' for understanding millennial scale climate variability. I will review observational and mechanistic arguments for the variation of sea level on Antarctic, Greenland and absolute time scales.

Minimally Invasive Surgery (MIS) Approaches to Thoracolumbar Trauma.

PubMed

Kaye, Ian David; Passias, Peter

2018-03-01

Minimally invasive surgical (MIS) techniques offer promising improvements in the management of thoracolumbar trauma. Recent advances in MIS techniques and instrumentation for degenerative conditions have heralded a growing interest in employing these techniques for thoracolumbar trauma. Specifically, surgeons have applied these techniques to help manage flexion- and extension-distraction injuries, neurologically intact burst fractures, and cases of damage control. Minimally invasive surgical techniques offer a means to decrease blood loss, shorten operative time, reduce infection risk, and shorten hospital stays. Herein, we review thoracolumbar minimally invasive surgery with an emphasis on thoracolumbar trauma classification, minimally invasive spinal stabilization, surgical indications, patient outcomes, technical considerations, and potential complications.

A MIS 15-MIS 12 record of environmental changes and Lower Palaeolithic occupation from Valle Giumentina, central Italy

NASA Astrophysics Data System (ADS)

Villa, Valentina; Pereira, Alison; Chaussé, Christine; Nomade, Sébastien; Giaccio, Biagio; Limondin-Lozouet, Nicole; Fusco, Fabio; Regattieri, Eleonora; Degeai, Jean-Philippe; Robert, Vincent; Kuzucuoglu, Catherine; Boschian, Giovanni; Agostini, Silvano; Aureli, Daniele; Pagli, Marina; Bahain, Jean Jacques; Nicoud, Elisa

2016-11-01

An integrated geological study, including sedimentology, stable isotope analysis (δ18O, δ13C), geochemistry, micromorphology, biomarker analysis, 40Ar/39Ar geochronology and tephrochronology, was undertaken on the Quaternary infill of the Valle Giumentina basin in Central Italy, which also includes an outstanding archaeological succession, composed of nine human occupation levels ascribed to the Lower and Middle Palaeolithic. 40Ar/39Ar dating, and other palaeoenvironmental and tephrochronological data, constrain the sedimentary history of the whole succession to the MIS 15-MIS 12 interval, between 618 ± 13 ka and 456 ± 2 ka. Palaeoenvironmental proxies suggest that over this time interval of about 150 ka, sedimentary and pedogenic processes were mainly influenced by climatic changes, in particular by the pulsing of local mountain glaciers of the Majella massif. Specifically, the Valle Giumentina succession records glacio-fluvial and lacustrine sedimentation during the colder glacial periods and pedogenesis and/or alluvial sedimentation during the warmer interglacial and/or interstadial periods. During this interval, tectonics played a negligible role as a driving factor of local morphogenesis and sedimentation, whereas the general regional uplift experienced in the Middle Pleistocene led to capture of the basin and its definitive extinction after MIS 12. These data substantially improve previous knowledge of the chronology and sedimentary evolution of the succession, providing for the first time, a well constrained chronological and palaeoenvironmental framework for the archaeological and human palaeoecological record of Valle Giumentina.

Evidence for Millennial-Scale Climate Variability in the Surface Waters Above ODP Site 980, NE Atlantic Ocean During the Last Glacial Interval (MIS 4-2)

NASA Astrophysics Data System (ADS)

Michaud, J. R.; Cullen, J. L.; McManus, J. F.; Oppo, D. W.

2004-05-01

Successful efforts to recover quality high sedimentation rate deep-sea sediment sections from the North Atlantic over the last decade have produced a number of studies demonstrating that climate instability at sub-orbital and even millennial time-scales is a pervasive component of Late Pleistocene North Atlantic climate. This is particularly true during Marine Isotope Stages (MIS) 4-2, i.e., the last glacial interval. One such high sedimentation rate section was recovered at ODP Site 980, Northeast Atlantic Ocean where sedimentation rates during MIS 4-2 exceed 15cm/kyr. Recently, we have begun to generate more detailed records from MIS 4-2 at Site 980 by reducing our sampling interval from 20 to around 2.5 cm, improving the resolution of our records an order of magnitude, from 1200-1300 to 100-200 years. 300 samples were used to generate high resolution records of changes in the input of ice-rafted detritus (IRD), along with limited data documenting changes in the relative abundance of the N. pachyderma, left coiling, which can be evaluated within the context of our previously generated lower resolution planktic and benthic oxygen isotope records used to generate our age model for this interval. Our previously published low resolution IRD record enabled us to identify Heinrich events 1-6 within the sediment interval deposited during the last glacial. Each event is characterized by IRD concentrations ranging from 500 to over 2500 lithic grains >150 microns per gram sediment. Superimposing our new high resolution IRD record reveals that Heinrich events 3,2,1 occurring at approximately 32, 23, and 17 kya, respectively, are each composed of a series of separate abrupt rapid increases in IRD concentrations approaching 1,000 grains per gram. An additional comparable event occurring at approximately 20 kya has also been identified. In the early part of the last glacial H6, H5, and H4 occurring at approximately 66, 47, and 38 kya, respectively, are recorded as much more

A climate model study of an intense Asian Monsoon in a La Niña-like climate of MIS-13

NASA Astrophysics Data System (ADS)

Karami, M. P.; Berger, A.; Herold, N.; Yin, Q. Z.

2012-04-01

Studying the paleo-monsoon during past interglacials is a valuable approach to improve our understanding of the monsoon system in present-day and future climates. We focus on Marine Isotopic stage 13 (MIS-13; ~0.5 Ma) which was a relatively cool interglacial, but with a paradoxically intense monsoonal precipitation over eastern and southern Asia. Our main goal is to understand the physics-based mechanism driving the intense monsoon, specifically the East Asian Summer Monsoon (EASM), during MIS-13. We applied both an intermediate complexity model (LOVECLIM) as well as fully coupled general circulation models (HadCM3 and CCSM3) to simulate pre-industrial and MIS-13 climates. The boundary conditions for MIS-13 were chosen for 506 ka with Northern-Hemisphere (NH) summer at perihelion and a CO2 concentration of 240 ppm. For pre-industrial, NH-winter occurring at perihelion and a CO2 concentration of 280 ppm were prescribed. Preliminary analysis of the model results shows different atmospheric and oceanic features in MIS-13 compared to the pre-industrial which could affect the EASM. The Northern Pacific Subtropical High (NPSH), which is an important factor in controlling the EASM, strengthened and extended to the northwest in MIS-13 partially due to cooling of the central Pacific Ocean. This in turn brought more moisture from the Central Pacific to the EASM-region and caused a northwestward shift and bending of the low-level jet along East Asia. The change in the low-level jet subsequently increased the meridional wind velocity at 850 mbar in the EASM-region providing more moisture from the tropical Pacific and Indian Oceans. In addition, higher sea-surface temperature in the Indian Ocean during MIS-13 further increased the source of moisture for the EASM. The Asian low, which is another component of the EASM-system, also shifted eastward moving the rain band northward. Moreover, it was found that MIS-13 had a dominant La Niña condition in the tropical Pacific. La Ni

Language, Violence, and Indian Mis-education.

ERIC Educational Resources Information Center

Russell, Caskey

2002-01-01

Traces the history of institutionalized violence--both physical and symbolic--within American Indian education; the legacy of shame and guilt from the boarding school era, when oppression was internalized; and the relationship of such "mis-education" to the decline of Tlingit language and culture in southwestern Alaska. Discusses…

Investigation of MIS-sensor sensitivity to vapor of unsymmetrical dimethylgydrazine in air

NASA Astrophysics Data System (ADS)

Filipchuk, D. V.; Litvinov, A. V.; Etrekova, M. O.; Nozdrya, D. A.

2018-01-01

The sensitivity of MIS-sensor to the products of thermal decomposition of unsymmetrical dimethylhydrazine was investigated. It is shown that MIS sensor is able to detect the concentrations of the test substance by the means of the certain products of its thermal decomposition (ammonia and nitric dioxide).

Subsurface North Atlantic warming as a trigger of rapid cooling events: evidence from the early Pleistocene (MIS 31-19)

NASA Astrophysics Data System (ADS)

Hernández-Almeida, I.; Sierro, F.-J.; Cacho, I.; Flores, J.-A.

2015-04-01

Subsurface water column dynamics in the subpolar North Atlantic were reconstructed in order to improve the understanding of the cause of abrupt ice-rafted detritus (IRD) events during cold periods of the early Pleistocene. We used paired Mg / Ca and δ18O measurements of Neogloboquadrina pachyderma (sinistral - sin.), deep-dwelling planktonic foraminifera, to estimate the subsurface temperatures and seawater δ18O from a sediment core from Gardar Drift, in the subpolar North Atlantic. Carbon isotopes of benthic and planktonic foraminifera from the same site provide information about the ventilation and water column nutrient gradient. Mg / Ca-based temperatures and seawater δ18O suggest increased subsurface temperatures and salinities during ice-rafting, likely due to northward subsurface transport of subtropical waters during periods of weaker Atlantic Meridional Overturning Circulation (AMOC). Planktonic carbon isotopes support this suggestion, showing coincident increased subsurface ventilation during deposition of IRD. Subsurface accumulation of warm waters would have resulted in basal warming and break-up of ice-shelves, leading to massive iceberg discharges in the North Atlantic. The release of heat stored at the subsurface to the atmosphere would have helped to restart the AMOC. This mechanism is in agreement with modelling and proxy studies that observe a subsurface warming in the North Atlantic in response to AMOC slowdown during Marine Isotope Stage (MIS) 3.

Three-year postoperative outcomes between MIS and conventional TLIF in1-segment lumbar disc herniation.

PubMed

Lv, You; Chen, Jingyang; Chen, Jinchuan; Wu, Yuling; Chen, Xiangyang; Liu, Yi; Chu, Zhaoming; Sheng, Luxin; Qin, Rujie; Chen, Ming

2017-06-01

The aim of this study is to assess the long-term clinical and radiological outcomes between minimally invasive (MIS) and conventional transforaminal lumbar interbody fusion (TLIF) in treating one-segment lumbar disc herniation (LDH). One-hundred and six patients treated by MIS-TLIF (50 cases) or conventional TLIF (56 cases) were included. Perioperative results were evaluated. Clinical outcomes were compared preoperatively and postoperatively. Radiologic parameters were based on a comparison of preoperative and three-year postoperative lumbar lordosis, segmental lordosis, sacral slope, the cross-sectional area of the paraspinal muscle and fusion rates. MIS TILF had significantly less blood, shorter operation time, mean return to work time and lower intramuscular pressure compared with the conventional group during the operation. VAS scores for lower back pain and ODI in MIS-TLIF were significantly decreased. The mean cross-sectional area of the paraspinal muscle was significantly decreased after surgery in the conventional TLIF group and no significant intragroup differences were established in the MIS-TLIF group. No significant differences were found in fusion rate, lumbar lordosis, segmental lordosis and sacral slope. Both MIS and conventional TLIF were beneficial for patients with LDH. However, MIS-TLIF manifests a great improvement in perioperative outcomes, low back pain, disability and preventing paraspinal muscle atrophy during the follow-up period observation.

Thomas checks the condition of the MIS-B middeck locker experiment

NASA Image and Video Library

1995-07-28

STS070-329-022 (13-22 JULY 1995)--- Astronaut Donald A. Thomas, mission specialist, prepares to activate the Microcapsules in Space (MIS-B) experiment on the space shuttle Discovery?s middeck. MIS-B is an Army project to improve the understanding of microencapsulated drug technology and demonstrate the feasibility of producing pharmaceutical microcapsules in the weightlessness of space. This is the second flight of the experiment, which originally flew on STS-53 in 1992. Microcapsules are tiny spheres about 50 to 100 micrometers in diameter (about the thickness of a strand of human hair). They are used to develop high-performance chemical products and innovative pharmaceuticals such as time-release prescriptions. The drug used in the MIS experiments was ampicillin.

A Mis-recognized Medical Vocabulary Correction System for Speech-based Electronic Medical Record

PubMed Central

Seo, Hwa Jeong; Kim, Ju Han; Sakabe, Nagamasa

2002-01-01

Speech recognition as an input tool for electronic medical record (EMR) enables efficient data entry at the point of care. However, the recognition accuracy for medical vocabulary is much poorer than that for doctor-patient dialogue. We developed a mis-recognized medical vocabulary correction system based on syllable-by-syllable comparison of speech text against medical vocabulary database. Using specialty medical vocabulary, the algorithm detects and corrects mis-recognized medical vocabularies in narrative text. Our preliminary evaluation showed 94% of accuracy in mis-recognized medical vocabulary correction.

Developing an Introductory Level MIS Project in Accordance with AACSB Assurance of Learning Standard 15

ERIC Educational Resources Information Center

Schwieger, Dana

2012-01-01

As part of the introductory level management information systems (MIS) course, faculty are asked to introduce the students to MIS concepts as well as to help them develop technology-related skills benefitting them in their course work and beyond. However, with a vast array of MIS topics that could be covered and class time at a premium, it is…

Photocapacitive MIS infrared detectors

NASA Technical Reports Server (NTRS)

Sher, A.; Lu, S. S.-M.; Moriarty, J. A.; Crouch, R. K.; Miller, W. E.

1978-01-01

A new class of room-temperature infrared detectors has been developed through use of metal-insulator-semiconductor (MIS) or metal-insulator-semiconductor-insulator-metal (MISIM) slabs. The detectors, which have been fabricated from Si, Ge and GaAs, rely for operation on the electrical capacitance variations induced by modulated incident radiation. The peak detectivity for a 1000-A Si MISIM detector is comparable to that of a conventional Si detector functioning in the photovoltaic mode. Optimization of the photocapacitive-mode detection sensitivity is discussed.

Electrical characteristics of TMAH-surface treated Ni/Au/Al2O3/GaN MIS Schottky structures

NASA Astrophysics Data System (ADS)

Reddy, M. Siva Pratap; Lee, Jung-Hee; Jang, Ja-Soon

2014-03-01

The electrical characteristics and reverse leakage mechanisms of tetramethylammonium hydroxide (TMAH) surface-treated Ni/Au/Al2O3/GaN metal-insulator-semiconductor (MIS) diodes were investigated by using the current-voltage ( I-V) and capacitance-voltage ( C-V) characteristics. The MIS diode was formed on n-GaN after etching the AlGaN in the AlGaN/GaN heterostructures. The TMAH-treated MIS diode showed better Schottky characteristics with a lower ideality factor, higher barrier height and lower reverse leakage current compared to the TMAH-free MIS diode. In addition, the TMAH-free MIS diodes exhibited a transition from Poole-Frenkel emission at low voltages to Schottky emission at high voltages, whereas the TMAH-treated MIS diodes showed Schottky emission over the entire voltage range. Reasonable mechanisms for the improved device-performance characteristics in the TMAH-treated MIS diode are discussed in terms of the decreased interface state density or traps associated with an oxide material and the reduced tunneling probability.

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

PubMed Central

Silkworth, William T.; Nardi, Isaac K.; Scholl, Lindsey M.; Cimini, Daniela

2009-01-01

Many cancer cells display a CIN (Chromosome Instability) phenotype, by which they exhibit high rates of chromosome loss or gain at each cell cycle. Over the years, a number of different mechanisms, including mitotic spindle multipolarity, cytokinesis failure, and merotelic kinetochore orientation, have been proposed as causes of CIN. However, a comprehensive theory of how CIN is perpetuated is still lacking. We used CIN colorectal cancer cells as a model system to investigate the possible cellular mechanism(s) underlying CIN. We found that CIN cells frequently assembled multipolar spindles in early mitosis. However, multipolar anaphase cells were very rare, and live-cell experiments showed that almost all CIN cells divided in a bipolar fashion. Moreover, fixed-cell analysis showed high frequencies of merotelically attached lagging chromosomes in bipolar anaphase CIN cells, and higher frequencies of merotelic attachments in multipolar vs. bipolar prometaphases. Finally, we found that multipolar CIN prometaphases typically possessed γ-tubulin at all spindle poles, and that a significant fraction of bipolar metaphase/early anaphase CIN cells possessed more than one centrosome at a single spindle pole. Taken together, our data suggest a model by which merotelic kinetochore attachments can easily be established in multipolar prometaphases. Most of these multipolar prometaphase cells would then bi-polarize before anaphase onset, and the residual merotelic attachments would produce chromosome mis-segregation due to anaphase lagging chromosomes. We propose this spindle pole coalescence mechanism as a major contributor to chromosome instability in cancer cells. PMID:19668340

Basic mechanisms study for MIS solar cell structures on GaAs

NASA Technical Reports Server (NTRS)

Fonash, S. J.

1978-01-01

The solar cell structure examined is the MIS configuration on (n) GaAs. The metal room temperature oxide/(n) GaAs materials system was studied. Metals with electronegativities varying from 2.4 (Au) to 1.5 (Al) were used as the upper electrode. The thinnest metallization that did not interfere with the measurement techniques (by introducing essentially transmission line series resistance problems across a device) was used. Photovoltaic response was not optimized.

Pharyngeal mis-sequencing in dysphagia: characteristics, rehabilitative response, and etiological speculation.

PubMed

Huckabee, Maggie-Lee; Lamvik, Kristin; Jones, Richard

2014-08-15

Clinical data are submitted as documentation of a pathophysiologic feature of dysphagia termed pharyngeal mis-sequencing and to encourage clinicians and researchers to adopt more critical approaches to diagnosis and treatment planning. Recent clinical experience has identified a cohort of patients who present with an atypical dysphagia not specifically described in the literature: mis-sequenced constriction of the pharynx when swallowing. As a result, they are unable to coordinate streamlined bolus transfer from the pharynx into the esophagus. This mis-sequencing contributes to nasal redirection, aspiration, and, for some, the inability to safely tolerate an oral diet. Sixteen patients (8 females, 8 males), with a mean age of 44 years (range=25-78), had an average time post-onset of 23 months (range=2-72) at initiation of intensive rehabilitation. A 3-channel manometric catheter was used to measure pharyngeal pressure. The average peak-to-peak latency between nadir pressures at sensor-1 and sensor-2 was 15 ms (95% CI, -2 to 33 ms), compared to normative mean latency of 239 ms (95% CI, 215 to 263 ms). Rehabilitative responses are summarized, along with a single detailed case report. It is unclear from these data if pharyngeal mis-sequencing is (i) a pathological feature of impaired motor planning from brainstem damage or (ii) a maladaptive compensation developed in response to chronic dysphagia. Future investigation is needed to provide a full report of pharyngeal mis-sequencing, and the implications on our understanding of underlying neural control of swallowing. Copyright © 2014 Elsevier B.V. All rights reserved.

Pre-mRNA mis-splicing of sarcomeric genes in heart failure.

PubMed

Zhu, Chaoqun; Chen, Zhilong; Guo, Wei

2017-08-01

Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single gene in the genome, and mainly contributes to protein diversity in eukaryotic organisms. Alternative splicing is commonly governed by RNA binding proteins to meet the ever-changing demands of the cell. However, the mis-splicing may lead to human diseases. In the heart of human, mis-regulation of alternative splicing has been associated with heart failure. In this short review, we focus on alternative splicing of sarcomeric genes and review mis-splicing related heart failure with relatively well studied Sarcomeric genes and splicing mechanisms with identified regulatory factors. The perspective of alternative splicing based therapeutic strategies in heart failure has also been discussed. Copyright © 2016 Elsevier B.V. All rights reserved.

Abrupt termination of Marine Isotope Stage 16 (Termination VII) at 631.5 ka in Santa Barbara Basin, Californi

USGS Publications Warehouse

Dean, Walter E.; Kennett, James P.; Behl, Richard J.; Nicholson, Craig; Sorlien, Christopher C.

2015-01-01

The Marine Isotope Stage 16–15 boundary (Termination VII) is the first deglacial warming step of the late Quaternary following the mid-Pleistocene transition (MPT), when 41 kyr climatic cycles shifted to strong 100 kyr cycles. The detailed structure of this important climatic event has remained unknown until now. Core MV0508-19JPC from Santa Barbara Basin, California, contains a decadal-scale climatic and geochemical sediment record of 4000 years duration that includes the early part of this deglacial episode. This record reveals that the climatic shift during the early deglacial occurred rapidly (<700 years), in a progression of three abrupt warming steps. The onset of Marine Isotope Stage (MIS) 15 was remarkably abrupt with 4–5°C sea surface warming in ~50 years. The deglacial sequence contains the well-dated Lava Creek tephra (631.3 ± 4 ka) from Yellowstone Caldera used to date the onset of Termination VII at 631.5 ka. The late MIS 16 and early MIS 15 interval exhibits multiple decadal-scale negative excursions in δ13C of planktic foraminifera, likely the result of repeated discharges of methane from methane hydrates associated with both ocean warming and low sea level. A warm interstadial that interrupts late MIS 16 is marked by elevated concentrations of redox-sensitive elements indicating sulfidic, oxygen-deficient bottom and pore-waters, and elevated concentrations of total organic carbon and Cd, reflecting increased surface productivity. Unlike younger sediments on the California margin, these indicators of increased productivity and low dissolved oxygen do not consistently correspond with each other or with preserved laminations, possibly reflecting instability of a still evolving ocean-atmosphere system following the MPT.

An Empirical Study about the Critical Factors Affecting MIS Students' Job Opportunities

ERIC Educational Resources Information Center

Fang, Xiang; Lee, Sooun

2005-01-01

For the first time in many years, Management Information Systems (MIS) students and faculty are seeking ways to improve full-time job placement for program graduates. Due to sharp IT budget cuts, the slowing economy, and outsourcing, job opportunities for MIS graduates have become scarcer than ever before. In addition to achieving good academic…

Burried MIS 5 abrasion platforms in the Bay of Koper (Gulf of Trieste, Northern Adriatic) confirm long-term subsidence of the Northern Adriatic region

NASA Astrophysics Data System (ADS)

Trobec, Ana; Šmuc, Andrej; Poglajen, Sašo; Vrabec, Marko

2016-04-01

The youngest seafloor sediments of the Gulf of Trieste (Northern Adriatic) are represented by an up to several 100 meters thick succession of Pliocene to Quaternary continental and shallow-marine deposits recording numerous transgressive-regressive cycles. These sediments are separated from older lithologies (mainly Eocene flysch) by an erosional unconformity. Previous geophysical campaigns conducted in the Italian part of the Gulf of Trieste revealed a complex undulating morphology of the unconformity characterised by numerous morphological steps in the flysch appearing between 40 and 200 m below sea level. From correlation with onshore well data from the Friuli and Veneto area it is assumed that the highest system of these unconformities located at approximately 40 mbsl represents a marine abrasion platform formed during the MIS 5 period sea-level highstand. We present the first observations of these abrasion platforms in the Bay of Koper in the southern (Slovenian) part of the Gulf of Trieste. A series of perpendicular sub-bottom sonar profiles with a spacing of 250-500 meters was acquired in the Bay of Koper between 2009 and 2012 with the Innomar parametric sediment echo sounder SES-2000. Along the northern coast of the bay several acoustic facies were resolved, including the top erosional unconformity surface of the flysch. On this surface we located platforms at 35 ms (platform A), 40 ms (platform B) and 50 ms (platform C) of two-way-travel time. The top of abrasion platform B coincides with the top of a sediment progradational wedge which overlies abrasion platform C. No progradational wedge is developed at the top of platform A. Due to signal attenuation and multiples sub-bottom profiles could not be interpreted below 53 ms TWT time. We used a sound velocity of 1650 m/s for the time to depth conversion, which places the platforms at the depth of 28, 33 and 41 mbsl, respectively. Assuming that the abrasion platforms are a remnant of the MIS 5 highstand, this

INPP5E Preserves Genomic Stability through Regulation of Mitosis.

PubMed

Sierra Potchanant, Elizabeth A; Cerabona, Donna; Sater, Zahi Abdul; He, Ying; Sun, Zejin; Gehlhausen, Jeff; Nalepa, Grzegorz

2017-03-15

The partially understood phosphoinositide signaling cascade regulates multiple aspects of cellular metabolism. Previous studies revealed that INPP5E, the inositol polyphosphate-5-phosphatase that is mutated in the developmental disorders Joubert and MORM syndromes, is essential for the function of the primary cilium and maintenance of phosphoinositide balance in nondividing cells. Here, we report that INPP5E further contributes to cellular homeostasis by regulating cell division. We found that silencing or genetic knockout of INPP5E in human and murine cells impairs the spindle assembly checkpoint, centrosome and spindle function, and maintenance of chromosomal integrity. Consistent with a cell cycle regulatory role, we found that INPP5E expression is cell cycle dependent, peaking at mitotic entry. INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit. Our findings identify the previously unknown, essential role of INPP5E in mitosis and prevention of aneuploidy, providing a new perspective on the function of this phosphoinositide phosphatase in health and development. Copyright © 2017 Sierra Potchanant et al.

Duodenal Atresia: Open versus MIS Repair-Analysis of Our Experience over the Last 12 Years.

PubMed

Chiarenza, Salvatore Fabio; Bucci, Valeria; Conighi, Maria Luisa; Zolpi, Elisa; Costa, Lorenzo; Fasoli, Lorella; Bleve, Cosimo

2017-01-01

Objective . Duodenal atresia (DA) routinely has been corrected by laparotomy and duodenoduodenostomy with excellent long-term results. We revisited the patients with DA treated in the last 12 years (2004-2016) comparing the open and the minimally invasive surgical (MIS) approach. Methods . We divided our cohort of patients into two groups. Group 1 included 10 patients with CDO (2004-09) treated with open procedure: 5, DA; 3, duodenal web; 2, extrinsic obstruction. Three presented with Down's syndrome while 3 presented with concomitant malformations. Group 2 included 8 patients (2009-16): 1, web; 5, DA; 2, extrinsic obstruction. Seven were treated by MIS; 1 was treated by Endoscopy. Three presented with Down's syndrome; 3 presented with concomitant malformations. Results . Average operating time was 120 minutes in Group 1 and 190 minutes in Group 2. In MIS Group the visualization was excellent. We recorded no intraoperative complications, conversions, or anastomotic leakage. Feedings started on 3-7 postoperative days. Follow-up showed no evidence of stricture or obstruction. In Group 1 feedings started within 10-22 days and we have 1 postoperative obstruction. Conclusions . Laparoscopic repair of DA is one of the most challenging procedures among pediatric laparoscopic procedures. These patients had a shorter length of hospitalization and more rapid advancement to full feeding compared to patients undergoing the open approach. Laparoscopic repair of DA could be the preferred technique, safe, and efficacious, in the hands of experienced surgeons.

MIS approach for diverticula of the esophagus

PubMed Central

2010-01-01

Purpose Diverticula of the esophagus represent a rare pathological entity. Distinct classifications of the disease imply different surgical concepts. Surgery should be reserved for symptomatic patients only. Minimally invasive surgery (MIS) for treatment of esophageal diverticula encompasses rigid and flexible intraluminal endoscopy, thoracoscopy and laparoscopy. We here give an overview on the pathogenesis of esophageal diverticula, the minimally invasive surgical techniques for treatment and the recent literature. Additionally, we present our own experience with MIS for midthoracic diverticula. Methods We analyzed the cases of patients who underwent MIS for midthoracic diverticula with regard to preoperative symptoms, perioperative and follow-up data. Results Three patients (two female, one male, age 79, 78 and 59 years) received thoracoscopic surgery for midthoracic diverticula. All patients reported of dysphagia and regurgitation. In two patients pH-investigation showed pathological reflux but manometry was normal in all patients. Operating time was 205, 135 and 141 minutes. We performed intraoperative intraluminal endoscopy in all patients. There were no intraoperative complications and although no surgical complications occured postoperatively one patient developed pneumonia which advanced to sepsis and lethal multi organ failure. Upon follow-up the two patients did not have recurrent diverticula or a recurrence of previous symptoms. Conclusions Surgery for diverticular disease of the esophagus has been associated with high rates of morbidity and mortality. Despite the lethal non-surgical complication we encountered, with regard to recent publications minimally invasive apporaches to treat patients with symptomatic esophageal diverticula entail lower rates of complications with better long term results in comparison to open surgery. PMID:20952348

Last interglacial climates

USGS Publications Warehouse

Kukla, G.J.; Bender, M.L.; de Beaulieu, J. -L.; Bond, G.; Broecker, W.S.; Cleveringa, P.; Gavin, J.E.; Herbert, T.D.; Imbrie, J.; Jouzel, J.; Keigwin, L.D.; Knudsen, K.-L.; McManus, J.F.; Merkt, J.; Muhs, D.R.; Muller, H.; Poore, R.Z.; Porter, S.C.; Seret, G.; Shackleton, N.J.; Turner, C.; Tzedakis, P.C.; Winograd, I.J.

2002-01-01

The last interglacial, commonly understood as an interval with climate as warm or warmer than today, is represented by marine isotope stage (MIS) 5e, which is a proxy record of low global ice volume and high sea level. It is arbitrarily dated to begin at approximately 130,000 yr B.P. and end at 116,000 yr B.P. with the onset of the early glacial unit MIS 5d. The age of the stage is determined by correlation to uranium-thorium dates of raised coral reefs. The most detailed proxy record of interglacial climate is found in the Vostok ice core where the temperature reached current levels 132,000 yr ago and continued rising for another two millennia. Approximately 127,000 yr ago the Eemian mixed forests were established in Europe. They developed through a characteristic succession of tree species, probably surviving well into the early glacial stage in southern parts of Europe. After ca. 115,000 yr ago, open vegetation replaced forests in northwestern Europe and the proportion of conifers increased significantly farther south. Air temperature at Vostok dropped sharply. Pulses of cold water affected the northern North Atlantic already in late MIS 5e, but the central North Atlantic remained warm throughout most of MIS 5d. Model results show that the sea surface in the eastern tropical Pacific warmed when the ice grew and sea level dropped. The essentially interglacial conditions in southwestern Europe remained unaffected by ice buildup until late MIS 5d when the forests disappeared abruptly and cold water invaded the central North Atlantic ca. 107,000 yr ago. ?? 2002 University of Washington.

An Auto-management Thesis Program WebMIS Based on Workflow

NASA Astrophysics Data System (ADS)

Chang, Li; Jie, Shi; Weibo, Zhong

An auto-management WebMIS based on workflow for bachelor thesis program is given in this paper. A module used for workflow dispatching is designed and realized using MySQL and J2EE according to the work principle of workflow engine. The module can automatively dispatch the workflow according to the date of system, login information and the work status of the user. The WebMIS changes the management from handwork to computer-work which not only standardizes the thesis program but also keeps the data and documents clean and consistent.

Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP.

PubMed

Granic, Antoneta; Padmanabhan, Jaya; Norden, Michelle; Potter, Huntington

2010-02-15

Both sporadic and familial Alzheimer's disease (AD) patients exhibit increased chromosome aneuploidy, particularly trisomy 21, in neurons and other cells. Significantly, trisomy 21/Down syndrome patients develop early onset AD pathology. We investigated the mechanism underlying mosaic chromosome aneuploidy in AD and report that FAD mutations in the Alzheimer Amyloid Precursor Protein gene, APP, induce chromosome mis-segregation and aneuploidy in transgenic mice and in transfected cells. Furthermore, adding synthetic Abeta peptide, the pathogenic product of APP, to cultured cells causes rapid and robust chromosome mis-segregation leading to aneuploid, including trisomy 21, daughters, which is prevented by LiCl addition or Ca(2+) chelation and is replicated in tau KO cells, implicating GSK-3beta, calpain, and Tau-dependent microtubule transport in the aneugenic activity of Abeta. Furthermore, APP KO cells are resistant to the aneugenic activity of Abeta, as they have been shown previously to be resistant to Abeta-induced tau phosphorylation and cell toxicity. These results indicate that Abeta-induced microtubule dysfunction leads to aneuploid neurons and may thereby contribute to the pathogenesis of AD.

Paleoclimate reconstruction in the Levant region from the petrography and the geochemistry of a MIS 5 stalagmite from the Kanaan Cave, Lebanon

NASA Astrophysics Data System (ADS)

Nehme, C.; Verheyden, S.; Noble, S. R.; Farrant, A. R.; Delannoy, J. J.; Claeys, P.

2015-07-01

Lying at the transition between the temperate Mediterranean domain and subtropical deserts, the Levant is a key area to study the palaeoclimatic response over glacial-interglacial cycles. This paper presents a precisely dated last interglacial (MIS 5) stalagmite (129-84 ka) from the Kanaan Cave, Lebanon. Variations in growth rate and isotopic records indicate a warm humid phase at the onst of the last interglacial at ~129 ka that lasted until ~125 ka. A gradual shift in speleothem isotopic composition (125-122 ka) is driven mainly by the δ18O source effect of the Eastern Mediterranean surface waters during Sapropel S5. The onset of glacial inception began after ~122 ka, interrupted by a short wet pulse during Sapropel S4. Low growth rates and enriched oxygen and carbon values until ~84 ka indicate a transition to drier conditions during Northern Hemisphere glaciation.

Information Will Not Make You Well. MIS Re-examined. AIR Forum Paper 1978.

ERIC Educational Resources Information Center

Parker, John D.; Gardner, Don E.

Proponents of management information systems (MIS) have traditionally held that educational administrators are in need of better management information with which to make more informed planning and policy decisions. However, few successful implementations have been reported. Literature discussing the lack of success of MIS point to such factors as…

Speleothem evidence for the greening of the Sahara and its implications for the early human dispersal out of sub-Saharan Africa

NASA Astrophysics Data System (ADS)

El-Shenawy, Mohammed I.; Kim, Sang-Tae; Schwarcz, Henry P.; Asmerom, Yemane; Polyak, Victor J.

2018-05-01

Although there is a consensus that there were wet periods (greening events) in the Sahara in the past, the spatial extent and the timing of these greening events are still in dispute, yet critical to our understanding of the early human dispersal out of Africa. Our U-series dates of speleothems from the Northeastern Sahara (Wadi Sannur cave, Egypt) reveal that the periods of speleothem growth were brief and restricted to the interglacial Marine Isotope Stages MIS 5.5, MIS 7.3, and the early MIS 9 with a remarkable absence of the Holocene deposition of speleothems. These growth periods of Wadi Sannur cave speleothems correspond to periods of high rainfall and spread of vegetation (green Sahara). Distinct low δ18O values of speleothems indicate a distal moisture source that we interpret to be the Atlantic Ocean. These two lines of evidence from the Wadi Sannur speleothems thus suggest that maximal northward shifts in the West African monsoon system occurred during the growth periods of the speleothems, leading to greening of the Sahara, facilitating human migration into Eurasia. The periods of speleothem growth at Wadi Sannur cave are contemporaneous with important archeological events: (1) the earliest occurrence of the Middle Stone Age assemblages and Homo sapiens in North Africa (Jebel Irhoud), suggesting wide spread of greening conditions over the East-West transect of the Sahara, (2) the sharp technological break between the Acheulo-Yabrudian and the Mousterian industries, and (3) the arrival of Homo sapiens in Levant, indicating a key role of the Sahara route in early human dispersal out of Africa.

Recruitment of Hispanic Students into MIS Curricula

ERIC Educational Resources Information Center

McHaney, Roger; Martin, Dawne

2007-01-01

This paper provides several suggestions Hispanic student recruitment and retention in MIS or other business curricula. Cultural considerations like allocentrism and familialism are discussed along with the situation at K-State. It is believed that the recruitment and retention of Hispanic students can be influenced positively by considering…

C-reactive protein as early predictor of complications after minimally invasive colorectal resection.

PubMed

Pedrazzani, Corrado; Moro, Margherita; Mantovani, Guido; Lazzarini, Enrico; Conci, Simone; Ruzzenente, Andrea; Lippi, Giuseppe; Guglielmi, Alfredo

2017-04-01

Minimally invasive surgery (MIS) and enhanced recovery programs have been increasingly adopted in colorectal surgery. The aim of this prospective observational study was to evaluate the usefulness of the C-reactive protein (CRP) concentration measured on postoperative day 3 (POD-3) as an early predictor of severe complications after minimally invasive colorectal resection. From January 2014 to December 2015, 160 patients underwent resection of colorectal disease by MIS at the Division of General and Hepatobiliary Surgery, University of Verona Hospital Trust. Among these, CRP measurement was available on POD-3 in 143 patients. Conversion from laparoscopic to open surgery was necessary in 18 patients (12.6%). The mean POD-3 CRP concentration was significantly higher in patients who did than did not require conversions (205.6 ± 89.6 mg/L versus 104.6 ± 85.8 mg/L, respectively; P < 0.001), even in the absence of postoperative complications, and these patients were therefore excluded from the subsequent analysis. No deaths occurred during the study period, but complications occurred in 39 patients (31.2%). Among these, 24 patients (61.5%) developed surgery-related complications. A POD-3 CRP concentration of 120 mg/L was highly reliable for excluding the occurrence of surgery-related and severe complications. The negative predictive values for excluding surgery-related and severe complications was 86.8% and 97.7%, respectively. Assessment of the POD-3 CRP concentration after colorectal MIS is clinically significant for excluding the occurrence of surgery-related and severe complications. This measurement is a largely available, inexpensive, and easy-to-use tool that allows early and safe discharge in the setting of colorectal MIS and enhanced recovery programs. Copyright © 2016 Elsevier Inc. All rights reserved.

Southern California climate, hydrology and vegetation over the past ~96 ka from Baldwin Lake, San Bernardino Mountains, California

NASA Astrophysics Data System (ADS)

Glover, K. C.; Kirby, M. E.; Rhodes, E. J.; Silveira, E.; Stevens, L. R.; Lydon, S. E.; Whitaker, A.; MacDonald, G. M.

2015-12-01

Continuous paleoclimate records are scarce from terrestrial sites in Southern California beyond the Last Glacial Period (i.e. Marine Isotope Stage 2, MIS 2). Baldwin Lake in the Big Bear Valley, San Bernardino Mountains (SBM), is a playa lake in the ecotone between desert and Mediterranean climate and vegetation. We recovered a 27 m core from the site in 2012, which spans ~96 - 10 ka, based upon radiocarbon dating, infrared stimulated luminescence dating, and orbital tuning. Total organic content, total carbonate content, density, magnetic susceptibility, x-ray fluorescence, and grain size data show a lake system that responded in tandem with Marine Isotope State transitions. After the basin closed during MIS 5b, Baldwin Lake was productive for MIS 5a, then cycled through an inorganic phase to a highly organic lowstand by the end of MIS 4. A stratified lake of rapidly-deposited organic silt prevailed throughout MIS 3, then shifted to an inorganic, slow sedimentation regime during MIS 2. Paleoecological data (charcoal and fossil pollen) suggest that the Valley was most prone to wildfire during climate transitions (e.g. the end of the Last Glacial Maximum, ~21 ka). Forest cover was dominated by pine for much of the basin's history, save for the dry period at the onset of MIS 2, and a greater presence of oak woodland at the beginning of MIS 3. The reduced pine cover and increased sagebrush steppe in early MIS 2 suggests a more arid landscape of sagebrush steppe c. 29 - 25 ka, before reverting to wet conditions by the LGM. Throughout MIS 5a - 2, lake organic content fluctuates in tandem with solar radiation values; a possible link between lake productivity and insolation is currently being explored with biogenic silica (BiSi) analysis. The lake was desiccated by ~10 ka, perhaps driven by increasing insolation rates at the onset of MIS 1.

Structures of (2E,5E)-2-(4-cyanobenzylidene)-5-(4-dimethylaminobenzylidene)cyclopentanone and (2E,5E)-2-benzylidene-5-cinnamylidenecyclopentanone

NASA Astrophysics Data System (ADS)

Zoto, Christopher A.; MacDonald, John C.

2017-10-01

The X-ray crystal structures of (2E,5E)-2-(4-cyanobenzylidene)-5-(4-dimethylaminobenzylidene)cyclopentanone (I) and (2E,5E)-2-benzylidene-5-cinnamylidenecyclopentanone (II) are presented, compared to the gas phase structures calculated using density functional theory, and discussed in the context of the photophysical behavior exhibited by I and II. Compound I crystallizes in the triclinic space group P 1 bar with a = 6.8743(2) Å, b = 8.8115(2) Å, c = 14.9664(4) Å, α = 77.135(2)°, β = 81.351(2)°, γ = 80.975(2)°, and Z = 2, and exhibits a planar structure. Compound II crystallizes in the monoclinic space group C2/c with a = 33.4281(10) Å, b = 11.9668(4) Å, c = 7.8031(2) Å, β = 92.785(2)°, and Z = 8, and adopts a nonplanar structure in the solid state and calculated structure.

Paleoproductivity vs. influx of terrestrial biomarker in sediment from the Korean Plateau, East Sea (Japan Sea) since the MIS 11

NASA Astrophysics Data System (ADS)

Hyun, Sangmin; Suh, Yean Jee; Ikehara, Miroru

2015-04-01

A piston core collected from the Korean Plateau, East Sea (Japan Sea) of Korea was conducted in terms of variations in paleoproductivity and influx of terrestrial biomarker. The distribution of terrestrial n-alkanes signatures is characterized by the occurrence of high odd number frequency with a minor contribution of specific compound (nC27 only). Average Chain Length (ACL) and Carbon Preferences Index (CPI), both of which are derived from n-alkane combination, show similar shifting between glacial and interglacial periods. Previous studies of SST variation have shown that glacial-interglacial scale changes were quite variable with the maximum range of 26oC in MIS 7, and the minimum range of 12oC during MIS 2 and 6. Therefore, paleovegetation communities had been changed in responding to paleoclimatological variations, and the input amount of terrestrial compound was strongly linked with paleoclimatologic changes. The isotopic composition of δ13C and δ15N of organic matter, which showed extreme temporal variation since MIS 11, indicates the influx of large amount of terrestrial organic matter from the neighboring terrestrial environments during MIS 2, 8 and 10. In particular, depleted values of δ13Corg during MIS 2, 8 and 10 were coincident with lower nitrogen isotope values indicating local paleoceanographic effects such as paleoproductivity changes. Decoupling between δ13Corg and δ15Norg during MIS 1, 3, 5, 7 and coupling of the two during MIS 8 and 11 can be observed, which appear to be interpreted as local productivity changes. In particular, high abundance of cholesterol and C21 n-alkanes, which were derived from diatom, increased during interglacial periods. Therefore, alkenones, SST and n-alkanes signatures coincide with δ13Corg and δ15Norg variations during glacial-interglacial cycles and further strongly associated with cholesterol abundance suggesting that the paleoenvironmental conditions in East Sea during glacial-interglacial periods were

Toward optimal implementation of cancer prevention and control programs in public health: a study protocol on mis-implementation.

PubMed

Padek, Margaret; Allen, Peg; Erwin, Paul C; Franco, Melissa; Hammond, Ross A; Heuberger, Benjamin; Kasman, Matt; Luke, Doug A; Mazzucca, Stephanie; Moreland-Russell, Sarah; Brownson, Ross C

2018-03-23

Much of the cancer burden in the USA is preventable, through application of existing knowledge. State-level funders and public health practitioners are in ideal positions to affect programs and policies related to cancer control. Mis-implementation refers to ending effective programs and policies prematurely or continuing ineffective ones. Greater attention to mis-implementation should lead to use of effective interventions and more efficient expenditure of resources, which in the long term, will lead to more positive cancer outcomes. This is a three-phase study that takes a comprehensive approach, leading to the elucidation of tactics for addressing mis-implementation. Phase 1: We assess the extent to which mis-implementation is occurring among state cancer control programs in public health. This initial phase will involve a survey of 800 practitioners representing all states. The programs represented will span the full continuum of cancer control, from primary prevention to survivorship. Phase 2: Using data from phase 1 to identify organizations in which mis-implementation is particularly high or low, the team will conduct eight comparative case studies to get a richer understanding of mis-implementation and to understand contextual differences. These case studies will highlight lessons learned about mis-implementation and identify hypothesized drivers. Phase 3: Agent-based modeling will be used to identify dynamic interactions between individual capacity, organizational capacity, use of evidence, funding, and external factors driving mis-implementation. The team will then translate and disseminate findings from phases 1 to 3 to practitioners and practice-related stakeholders to support the reduction of mis-implementation. This study is innovative and significant because it will (1) be the first to refine and further develop reliable and valid measures of mis-implementation of public health programs; (2) bring together a strong, transdisciplinary team with

The role of ultra-thin SiO2 layers in metal-insulator-semiconductor (MIS) photoelectrochemical devices (Presentation Recording)

NASA Astrophysics Data System (ADS)

Esposito, Daniel V.

2015-08-01

Solid-state junctions based on a metal-insulator-semiconductor (MIS) architecture are of great interest for a number of optoelectronic applications such as photovoltaics, photoelectrochemical cells, and photodetection. One major advantage of the MIS junction compared to the closely related metal-semiconductor junction, or Schottky junction, is that the thin insulating layer (1-3 nm thick) that separates the metal and semiconductor can significantly reduce the density of undesirable interfacial mid-gap states. The reduction in mid-gap states helps "un-pin" the junction, allowing for significantly higher built-in-voltages to be achieved. A second major advantage of the MIS junction is that the thin insulating layer can also protect the underlying semiconductor from corrosion in an electrochemical environment, making the MIS architecture well-suited for application in (photo)electrochemical applications. In this presentation, discontinuous Si-based MIS junctions immersed in electrolyte are explored for use as i.) photoelectrodes for solar-water splitting in photoelectrochemical cells (PECs) and ii.) position-sensitive photodetectors. The development and optimization of MIS photoelectrodes for both of these applications relies heavily on understanding how processing of the thin SiO2 layer impacts the properties of nano- and micro-scale MIS junctions, as well as the interactions of the insulating layer with the electrolyte. In this work, we systematically explore the effects of insulator thickness, synthesis method, and chemical treatment on the photoelectrochemical and electrochemical properties of these MIS devices. It is shown that electrolyte-induced inversion plays a critical role in determining the charge carrier dynamics within the MIS photoelectrodes for both applications.

Investigation into MIS 11 in the U.S. Great Basin Using Trace Elements and Stable Isotopes from two Lehman Caves Stalagmites

NASA Astrophysics Data System (ADS)

Neary, A.; McGee, D.; Tal, I.; Shakun, J. D.

2015-12-01

Marine Isotope Stage 11 (MIS 11) represents a long interglacial period of high temperatures and muted orbital variability that occurred around 424-374 kya, and is referred to as a 'super-interglacial'. MIS 11 is marked by especially pronounced high latitude warming in the Northern Hemisphere from 410-400 ka and thus presents a natural experiment for investigating the response of Great Basin precipitation to high latitude temperatures.MIS 11 is recorded by stalagmites LC3 and BT1 from Lehman Caves in Great Basin National Park, Nevada. LC3 represents 378-413 ka, while BT1 has a bottom age of 410 ka. Ongoing U-Th dating will refine chronologies from these samples. We will present stable isotope (δ13C and δ18O) and trace element (Mg/Ca and Sr/Ca) data from these stalagmites to study changes in precipitation recorded in them. Previous studies have shown a relationship between Mg/Ca, Sr/Ca, δ13C and prior calcite precipitation, and thus infiltration rates, in the cave system (Cross et al., 2015; Steponaitis et al., 2015). Meanwhile, δ18O has been shown to reflect larger scale atmospheric circulation.We will compare the records to previously published trace element and stable isotope data from more recent interglacials (Lachniet et al., 2014; Cross et al., 2015; Steponaitis et al., 2015) to test whether extensive high-latitude warming during MIS 11 was marked by anomalous precipitation patterns in the Great Basin. As they are coeval, we will also test the reproducibility between the stalagmites.References cited:Cross M., et al. (2015) Great Basin hydrology, paleoclimate, and connections with the North Atlantic: A speleothem stable isotope and trace element record from Lehman Caves, NV. Quaternary Science Reviews, in press.Steponaitis E., et al. (2015) Mid-Holocene drying the U.S. Great Basin recorded in Nevada speleothems. Quaternary Science Reviews, in press.Lachniet M. S., et al. (2014) Orbital control of western North America atmospheric circulation and climate

Orbital and Millennial-scale Variability Reflected on Continental-scale Vegetation Changes in the Southern Subtropics between MIS 6 and 3

NASA Astrophysics Data System (ADS)

Urrego, D. H.; Sanchez Goni, M.; Daniau, A.; Martinez, P.

2011-12-01

While our understanding of the effects of orbital and millennial-scale variability on the vegetation has grown during the past decades, empirical data from some climatically important periods and regions are still lacking. Scarce data exist for instance for deep-time glacial-interglacial cycles that could provide suitable analogs for current climate-change. Recent global-scale reconstructions of vegetation responses to rapid events during the last glacial cycle have been useful, however, these global compilations clearly show that some regions, namely the southern tropics and subtropics, remain understudied. Here we present results from one of the few available continental-scale vegetation records from southwestern Africa spanning the last glacial-interglacial cycle. We have conducted multiproxy analyses of marine core MD96 2098 (25°36'S, 12°38'E), retrieved from the Lüderitz slope off the coast of Namibia. Preservation of pollen and other terrestrial microfossils is facilitated at this site by the Benguela upwelling system and the proximity to the Orange River mouth. Chronological control has been derived from radiocarbon dates and marine isotope stratigraphy. We have used pollen analyses, benthic foraminifer d18O (1), X-ray Fluorescence, geochemistry (2), foraminifer assemblages and microcharcoal quantification (3) to reconstruct the terrestrial vegetation and climatic history of the southwestern part of Africa and offshore between 190 and 30 ka. We find that MIS 6 and 4 are characterized by expanding Semidesert and Fynbos vegetation, while expanding grasslands characterized MIS 5. The termination of MIS 5 is also punctuated by an expansion of humid forests. At millennial timescales, variations in grasslands are generally coupled with stadials and interstadials. The expansion of semidesert is associated with decreased continental humidity caused by the strengthening of the Benguela upwelling during MIS 6 and 4. The expansion of grasslands during the

Transmission line relay mis-operation detection based on time-synchronized field data

DOE PAGES

Esmaeilian, Ahad; Popovic, Tomo; Kezunovic, Mladen

2015-05-04

In this paper, a real-time tool to detect transmission line relay mis-operation is implemented. The tool uses time-synchronized measurements obtained from both ends of the line during disturbances. The proposed fault analysis tool comes into the picture only after the protective device has operated and tripped the line. The proposed methodology is able not only to detect, classify, and locate transmission line faults, but also to accurately confirm whether the line was tripped due to a mis-operation of protective relays. The analysis report includes either detailed description of the fault type and location or detection of relay mis-operation. As such,more » it can be a source of very useful information to support the system restoration. The focus of the paper is on the implementation requirements that allow practical application of the methodology, which is illustrated using the field data obtained the real power system. Testing and validation is done using the field data recorded by digital fault recorders and protective relays. The test data included several hundreds of event records corresponding to both relay mis-operations and actual faults. The discussion of results addresses various challenges encountered during the implementation and validation of the presented methodology.« less

M-I-S solar cell - Theory and experimental results

NASA Technical Reports Server (NTRS)

Childs, R.; Fortuna, J.; Geneczko, J.; Fonash, S. J.

1976-01-01

The paper presents an operating-mode analysis of an MIS solar cell and discusses the advantages which can arise as a result of the use of transport control, field shaping (increased n factor), and zero bias barrier height modification. It is noted that for an n-type semiconductor, it is relatively easy to obtain an enhanced n factor using acceptor-like states without an increase in diode saturation current, the converse being true for p-type semiconductors. Several MIS configurations are examined: an acceptor-like, localized state configuration producing field shaping and no change in diode saturation current, and acceptor-like localized configurations producing field shaping, with a decrease of diode saturation current, in one case, and an increase in the other.

Mis16 Independently Recognizes Histone H4 and the CENP-ACnp1-Specific Chaperone Scm3sp

DOE Office of Scientific and Technical Information (OSTI.GOV)

An, Sojin; Kim, Hanseong; Cho, Uhn-Soo

2015-09-04

CENP-A is a centromere-specific histone H3 variant that is required for kinetochore assembly and accurate chromosome segregation. For it to function properly, CENP-A must be specifically localized to centromeres. In fission yeast, Scm3sp and the Mis18 complex, composed of Mis16, Eic1, and Mis18, function as a CENP-ACnp1-specific chaperone and a recruiting factor, respectively, and together ensure accurate delivery of CENP-ACnp1 to centromeres. Although how Scm3sp specifically recognizes CENP-ACnp1 has been revealed recently, the recruiting mechanism of CENP-ACnp1 via the Mis18 complex remains unknown. In this study, we have determined crystal structures of Schizosaccharomyces japonicus Mis16 alone and in complex withmore » the helix 1 of histone H4 (H4α1). Crystal structures followed by mutant analysis and affinity pull-downs have revealed that Mis16 recognizes both H4α1 and Scm3sp independently within the CENP-ACnp1/H4:Scm3sp complex. This observation suggests that Mis16 gains CENP-ACnp1 specificity by recognizing both Scm3sp and histone H4. Our studies provide insights into the molecular mechanisms underlying specific recruitment of CENP-ACnp1/H4:Scm3sp into centromeres.« less

An Examination of the Introductory MIS Course

ERIC Educational Resources Information Center

Wang, Shouhong

2007-01-01

The introductory management information systems (MIS) course is a core course for all business majors at almost every business school. It is common for this course to have multiple sections taught by a mixed group of instructors each semester. Hence, consistent pedagogy and assessment are needed for multiple sections of this course. This paper…

Terrestrial biomarkers in the sediment of the East Sea (Japan Sea) since the MIS 11: implications for paleoproductivity and paleoclimatic changes

NASA Astrophysics Data System (ADS)

Hyun, S.; Suh, Y. J.; Woo, K. S.; Ikehara, M.

2014-12-01

Terrestrial biomarkers such as n-alkanes and cholesterol were analyzed to infer the variations of paleoproductivity and the corresponding paleoclimatologic information from the sediment of the Korean Plateau, East Sea (Japan Sea) since the Marine Isotope Stage (MIS) 11 (ca. 400 ka). Previous studies of SST variation have shown that glacial-interglacial scale changes were quite variable with the maximum range of 26oC in MIS 7, and the minimum range of 12oC during MIS 2 and 6. The distribution of terrestrial n-alkanes signatures is characterized by the occurrence of high odd number frequency with a minor contribution of specific compound (nC27 only). Average Chain Length (ACL) and Carbon Preferences Index (CPI), both of which are derived from n-alkane combination, show similar shifting between glacial and interglacial periods. This suggests that paleovegetation communities had been changed in responding to paleoclimatological variations, and the input amount of terrestrial compound was strongly linked with paleoclimatologic changes. In particular, depleted values of δ13Corg during MIS 2, 8 and 10 were coincident with lower nitrogen isotope values indicating local paleoceanographic effects such as paleoproductivity changes. Decoupling between δ13Corg and δ15Norg during MIS 1, 3, 5, 7 and coupling of the two during MIS 8 and 11 can be observed, which appear to be interpreted as local productivity changes. In particular, high abundance of cholesterol and C21 n-alkanes, which were derived from diatom, increased during interglacial periods. Therefore, alkenones, SST and n-alkanes signatures coincide with δ13Corg and δ15Norg variations during glacial-interglacial cycles and further strongly associated with cholesterol abundance suggesting that the paleoenvironmental conditions in East Sea during glacial-interglacial periods were sensitive not only to global climate changes but also to local paleceanographic variations. Surface water circulation around the Korea

E.C.E. Connection: A Newsletter for Early Childhood Education (E.C.E.), 1994-1998.

ERIC Educational Resources Information Center

E.C.E. Connection, 1998

1998-01-01

This document consists of the first 39 consecutive issues of the newsletter, "E.C.E. Connection," published monthly (except August) to offer information and support to early childhood practitioners. Articles from the 1994 issues include: "Some 'Affordable' Ideas To Brighten Your Classroom"; "A Notice Board: A Way To Keep…

What is the value of the SAGES/AORN MIS checklist? A multi-institutional practical assessment.

PubMed

Benham, Emily; Richardson, William; Dort, Jonathan; Lin, Henry; Tummers, A Michael; Walker, Travelyan M; Stefanidis, Dimitrios

2017-04-01

Surgical safety checklists reduce perioperative complications and mortality. Given that minimally invasive surgery (MIS) is dependent on technology and vulnerable to equipment failure, SAGES and AORN partnered to create a MIS checklist to optimize case flow and minimize errors. The aim of this project was to evaluate the effectiveness of the SAGES/AORN checklist in preventing disruptions and determine its ease of use. The checklist was implemented across four institutions and completed by the operating team. To assess its effectiveness, we recorded how often the checklist identified problems and how frequently each of the 45 checklist items were not completed. The perceived usefulness, ease of use, and frustration associated with checklist use were rated on a 5-point Likert scale by the surgeon. We assessed any differences dependent on timing of checklist completion and among institutions. The checklist was performed during MIS procedures (n = 114). When used before the procedure (n = 36), the checklist identified missing items in 13 cases (36.11 %). When used after the procedure (n = 61), the checklist identified missing items in 18 cases (29.51 %) that caused a delay of 4.1 ± 11.1 min. The most frequently missed items included preference card review (14.0 %), readiness of the carbon dioxide insufflator (8.7 %), and availability of the Veress needle (3.6 %). The checklist took an average of 3.6 ± 2.7 min to complete with its usefulness rated 2.6 ± 1.5, ease of use 2.0 ± 1.2, and frustration 1.3 ± 1.1. The checklist identified problems in 24 % of cases that led to preventable delays. The checklist was easy to complete and not frustrating, indicating it could improve operative flow. This study also identified the most useful items which may help abbreviate the checklist, minimizing the frustration and time taken to complete it while maximizing its utility. These attributes of the SAGES/AORN MIS checklist should be explored in future

A high-elevation, multi-proxy biotic and environmental record of MIS 6-4 from the Ziegler Reservoir fossil site, Snowmass Village, Colorado, USA

USGS Publications Warehouse

Miller, Ian M.; Pigati, Jeffrey S.; Anderson, R. Scott; Johnson, Kirk R.; Mahan, Shannon; Ager, Thomas A.; Baker, Richard G.; Blaauw, Maarten; Bright, Jordon; Brown, Peter M.; Bryant, Bruce; Calamari, Zachary T.; Carrara, Paul E.; Michael D., Cherney; Demboski, John R.; Elias, Scott A.; Fisher, Daniel C.; Gray, Harrison J.; Haskett, Danielle R.; Honke, Jeffrey S.; Jackson, Stephen T.; Jiménez-Moreno, Gonzalo; Kline, Douglas; Leonard, Eric M.; Lifton, Nathaniel A.; Lucking, Carol; McDonald, H. Gregory; Miller, Dane M.; Muhs, Daniel R.; Nash, Stephen E.; Newton, Cody; Paces, James B.; Petrie, Lesley; Plummer, Mitchell A.; Porinchu, David F.; Rountrey, Adam N.; Scott, Eric; Sertich, Joseph J. W.; Sharpe, Saxon E.; Skipp, Gary L.; Strickland, Laura E.; Stucky, Richard K.; Thompson, Robert S.; Wilson, Jim

2014-01-01

In North America, terrestrial records of biodiversity and climate change that span Marine Oxygen Isotope Stage (MIS) 5 are rare. Where found, they provide insight into how the coupling of the ocean–atmosphere system is manifested in biotic and environmental records and how the biosphere responds to climate change. In 2010–2011, construction at Ziegler Reservoir near Snowmass Village, Colorado (USA) revealed a nearly continuous, lacustrine/wetland sedimentary sequence that preserved evidence of past plant communities between ~ 140 and 55 ka, including all of MIS 5. At an elevation of 2705 m, the Ziegler Reservoir fossil site also contained thousands of well-preserved bones of late Pleistocene megafauna, including mastodons, mammoths, ground sloths, horses, camels, deer, bison, black bear, coyotes, and bighorn sheep. In addition, the site contained more than 26,000 bones from at least 30 species of small animals including salamanders, otters, muskrats, minks, rabbits, beavers, frogs, lizards, snakes, fish, and birds. The combination of macro- and micro-vertebrates, invertebrates, terrestrial and aquatic plant macrofossils, a detailed pollen record, and a robust, directly dated stratigraphic framework shows that high-elevation ecosystems in the Rocky Mountains of Colorado are climatically sensitive and varied dramatically throughout MIS 5.

Electrical characterizations of MIS structures based on variable-gap n(p)-HgCdTe grown by MBE on Si(0 1 3) substrates

NASA Astrophysics Data System (ADS)

Voitsekhovskii, A. V.; Nesmelov, S. N.; Dzyadukh, S. M.; Varavin, V. S.; Dvoretskii, S. A.; Mikhailov, N. N.; Yakushev, M. V.; Sidorov, G. Yu.

2017-12-01

Metal-insulator-semiconductor (MIS) structures based on n(p)-Hg1-xCdxTe (x = 0.22-0.40) with near-surface variable-gap layers were grown by the molecular-beam epitaxy (MBE) technique on the Si (0 1 3) substrates. Electrical properties of MIS structures were investigated experimentally at various temperatures (9-77 K) and directions of voltage sweep. The ;narrow swing; technique was used to determine the spectra of fast surface states with the exception of hysteresis effects. It is established that the density of fast surface states at the MCT/Al2O3 interface at a minimum does not exceed 3 × 1010 eV-1 × cm-2. For MIS structures based on n-MCT/Si(0 1 3), the differential resistance of the space-charge region in strong inversion mode in the temperature range 50-90 K is limited by the Shockley-Read-Hall generation in the space-charge region.

The Graduate MIS Security Course: Objectives and Challenges

ERIC Educational Resources Information Center

Jensen, Bradley K.; Guynes, Carl S.; Nyaboga, Andrew

2009-01-01

Given the magnitude of real and potential losses, both private and public employers increasingly expect graduates of management information systems (MIS) programs to understand information security concepts. The infrastructure requirements for the course includes setting up a secure laboratory environment to accommodate the development of viruses…

LaF3 insulators for MIS structures

NASA Technical Reports Server (NTRS)

Sher, A.; Tsuo, Y. H.; Moriarty, J. A.; Miller, W. E.; Crouch, R. K.; Seiber, B. A.

1979-01-01

Thin films of LaF3 deposited on Si or GaAs substrates have been observed to form blocking contacts with very high capacitances. This results in comparatively hysteresis-free and sharp C-V (capacitance-voltage) characteristics for MIS structures. Such structures have been used to study the interface states of GaAs with increased resolution and to construct improved photocapacitive infrared detectors.

Variations of the paleo-productivity in benthic foraminifera records in MIS 3 from western South China Sea

NASA Astrophysics Data System (ADS)

Niu, Y.; Du, J.; Huang, B.; Chen, M.

2010-12-01

Understanding climate change of last glacial age as the background information of climate forecasting is particularly important in climate research. Marine Isotope Stage 3 (MIS 3, 61-24 ka B.P.) is a relative warm and unstable period in the last glacial. Millennium scale abrupt climate changes, such as Heinrich events and Dansgaard-Oeschger (D-O) cycles, are identified in this period. Research topic on the variations of monsoon during the glacial cycles, especially in MIS 3, is critical for understanding low latitude climatic change and the global paleo-environment as a whole. Fortunately, high resolution sedimentary records in western South China Sea provide us valuable materials to uncover how East Asia Summer Monsoon (EASM) system acts in a highly fluctuating climate ambient like MIS 3. Core 17954 is located in the modern summer upwelling area off the Vietnam coast in western South China Sea (SCS), its sediments record the variations of upwelling generated by EASM. In this work, we carry out paleo-ecological analyses on planktonic ( Neogloboquadrina dutertrei, Globigerina bulloides) and benthic foraminifera (Bulimina aculeate, Uvigerina peregrina, Cibicidoides wuellerstorfi, ect.) sampled from Core 17954 to investigate paleo-productivity and nutrition change of western SCS and its relation to EASM. The results show that benthic and planktonic foraminifera have similar responses to nutrition change. Various indicators of productivity on the basis of benthic foraminiferal analyses reflect an overall three stage change trend: productivity gradually increases from the beginning of MIS 3 (60-40 ka) to its maximum during 35-30 ka, and finally declines after 30 ka. There is also another important discovery, if we observe the climate change in MIS 3 as a whole, we can also find western SCS and Northern Hemisphere High latitude have strong correspondences in such changes: Heinrich events coincided with high productivity events in the western SCS. Further, the result of

Reassessing the penultimate interglacial analog for current climate change, evidence from Antarctic dust

NASA Astrophysics Data System (ADS)

Aarons, S. M.; Aciego, S.; McConnell, J.

2017-12-01

Dust emissions and transport are linked to spatial and temporal climate variability, with dust provenance providing clues to past climate and climate impacts. The penultimate interglacial period (MIS 5e) has been suggested as an analog to Holocene climate change. We present the first evaluation of the MIS 5e ice archive developed at Taylor Glacier, East Antarctica and provide a record of dust transported to Taylor Glacier during MIS 5e. Our record shows significant differences between MIS 5e, Holocene, and pre-industrial dust transported to East Antarctica. The MIS 5e dust is sourced from New Zealand and southern South America (SSA), while the Holocene dust is sourced from local Antarctic, SSA, and potentially Australian sources. This profound change in composition suggests a variation in atmospheric transport pathways and/or paleo-environmental conditions between the interglacial periods, and indicates that MIS 5e should be reassessed as an analog for climate change and associated impacts.

MIS Case Study: I-94 Rehabilitation Project - Detroit, Michigan.

DOT National Transportation Integrated Search

1997-01-01

ISTEA includes specific requirements for inclusion in studies of Major Investment Projects in Metropolitan Planning Areas. The State of Michigan initiated a Major Investment Study (MIS) in October 1994 for the redesign and reconstruction of a 7 mile ...

Chironomid-based reconstructions of summer air temperature from lake deposits in Lyndon Stream, New Zealand spanning the MIS 3/2 transition

NASA Astrophysics Data System (ADS)

Woodward, C. A.; Shulmeister, J.

2007-01-01

We present chironomid-based temperature reconstructions from lake sediments deposited between ca 26,600 cal yr BP and 24,500 cal yr BP from Lyndon Stream, South Island, New Zealand. Summer (February mean) temperatures averaged 1 °C cooler, with a maximum inferred cooling of 3.7 °C. These estimates corroborate macrofossil and beetle-based temperature inferences from the same site and suggest climate amelioration (an interstadial) at this time. Other records from the New Zealand region also show a large degree of variability during the late Otiran glacial sequence (34,000-18,000 cal yr BP) including a phase of warming at the MIS 2/3 transition and a maximum cooling that did not occur until the global LGM (ca 20,000 cal yr BP). The very moderate cooling identified here at the MIS 2/3 transition confirms and enhances the long-standing discrepancy in New Zealand records between pollen and other proxies. Low abundances (<20%) of canopy tree pollen in records from late MIS 3 to the end of MIS 2 cannot be explained by the minor (<5 °C) cooling inferred from this and other studies unless other environmental parameters are considered. Further work is required to address this critical issue.

Structures of (5′S)-8,5′-Cyclo-2′-deoxyguanosine Mismatched with dA or dT

PubMed Central

2012-01-01

Diastereomeric 8,5′-cyclopurine 2′-deoxynucleosides, containing a covalent bond between the deoxyribose and the purine base, are induced in DNA by ionizing radiation. They are suspected to play a role in the etiology of neurodegeneration in xeroderma pigmentosum patients. If not repaired, the S-8,5′-cyclo-2′-deoxyguanosine lesion (S-cdG) induces Pol V-dependent mutations at a frequency of 34% in Escherichia coli. Most are S-cdG → A transitions, suggesting mis-incorporation of dTTP opposite the lesion during replication bypass, although low levels of S-cdG → T transversions, arising from mis-incorporation of dATP, are also observed. We report the structures of 5′-d(GTGCXTGTTTGT)-3′·5′-d(ACAAACAYGCAC)-3′, where X denotes S-cdG and Y denotes either dA or dT, corresponding to the situation following mis-insertion of either dTTP or dATP opposite the S-cdG lesion. The S-cdG·dT mismatch pair adopts a wobble base pairing. This provides a plausible rationale for the S-cdG → A transitions. The S-cdG·dA mismatch pair differs in conformation from the dG·dA mismatch pair. For the S-cdG·dA mismatch pair, both S-cdG and dA intercalate, but no hydrogen bonding is observed between S-cdG and dA. This is consistent with the lower levels of S-cdG → T transitions in E. coli. PMID:22309170

A Generalized Michaelis-Menten Equation in Protein Synthesis: Effects of Mis-Charged Cognate tRNA and Mis-Reading of Codon.

PubMed

Dutta, Annwesha; Chowdhury, Debashish

2017-05-01

The sequence of amino acid monomers in the primary structure of a protein is decided by the corresponding sequence of codons (triplets of nucleic acid monomers) on the template messenger RNA (mRNA). The polymerization of a protein, by incorporation of the successive amino acid monomers, is carried out by a molecular machine called ribosome. We develop a stochastic kinetic model that captures the possibilities of mis-reading of mRNA codon and prior mis-charging of a tRNA. By a combination of analytical and numerical methods, we obtain the distribution of the times taken for incorporation of the successive amino acids in the growing protein in this mathematical model. The corresponding exact analytical expression for the average rate of elongation of a nascent protein is a 'biologically motivated' generalization of the Michaelis-Menten formula for the average rate of enzymatic reactions. This generalized Michaelis-Menten-like formula (and the exact analytical expressions for a few other quantities) that we report here display the interplay of four different branched pathways corresponding to selection of four different types of tRNA.

The effect of sociodemographic (mis)match between interviewers and respondents on unit and item nonresponse in Belgium.

PubMed

Vercruyssen, Anina; Wuyts, Celine; Loosveldt, Geert

2017-09-01

Interviewer characteristics affect nonresponse and measurement errors in face-to-face surveys. Some studies have shown that mismatched sociodemographic characteristics - for example gender - affect people's behavior when interacting with an interviewer at the door and during the survey interview, resulting in more nonresponse. We investigate the effect of sociodemographic (mis)matching on nonresponse in two successive rounds of the European Social Survey in Belgium. As such, we replicate the analyses of the effect of (mis)matching gender and age on unit nonresponse on the one hand, and of gender, age and education level (mis)matching on item nonresponse on the other hand. Recurring effects of sociodemographic (mis)match are found for both unit and item nonresponse. Copyright © 2017 Elsevier Inc. All rights reserved.

ASYMPTOTICS FOR CHANGE-POINT MODELS UNDER VARYING DEGREES OF MIS-SPECIFICATION

PubMed Central

SONG, RUI; BANERJEE, MOULINATH; KOSOROK, MICHAEL R.

2015-01-01

Change-point models are widely used by statisticians to model drastic changes in the pattern of observed data. Least squares/maximum likelihood based estimation of change-points leads to curious asymptotic phenomena. When the change–point model is correctly specified, such estimates generally converge at a fast rate (n) and are asymptotically described by minimizers of a jump process. Under complete mis-specification by a smooth curve, i.e. when a change–point model is fitted to data described by a smooth curve, the rate of convergence slows down to n1/3 and the limit distribution changes to that of the minimizer of a continuous Gaussian process. In this paper we provide a bridge between these two extreme scenarios by studying the limit behavior of change–point estimates under varying degrees of model mis-specification by smooth curves, which can be viewed as local alternatives. We find that the limiting regime depends on how quickly the alternatives approach a change–point model. We unravel a family of ‘intermediate’ limits that can transition, at least qualitatively, to the limits in the two extreme scenarios. The theoretical results are illustrated via a set of carefully designed simulations. We also demonstrate how inference for the change-point parameter can be performed in absence of knowledge of the underlying scenario by resorting to subsampling techniques that involve estimation of the convergence rate. PMID:26681814

A high-resolution paleosecular variation record from Black Sea sediments indicating fast directional changes associated with low field intensities during marine isotope stage (MIS) 4

NASA Astrophysics Data System (ADS)

Nowaczyk, Norbert R.; Jiabo, Liu; Frank, Ute; Arz, Helge W.

2018-02-01

A total of nine sediment cores recovered from the Archangelsky Ridge in the SE Black Sea were systematically subjected to intense paleo- and mineral magnetic analyses. Besides 16 accelerator mass spectrometry (AMS) 14C ages available for another core from this area, dating was accomplished by correlation of short-term warming events during the last glacial monitored by high-resolution X-ray fluorescence (XRF) scanning as maxima in both Ca/Ti and K/Ti ratios in Black Sea sediments to the so-called 'Dansgaard-Oeschger events' recognized from Greenland ice cores. Thus, several hiatuses could be identified in the various cores during the last glacial/interglacial cycle. Finally, core sections documenting marine isotope stage (MIS) 4 at high resolution back to 69 ka were selected for detailed analyses. At 64.5 ka, according to obtained results from Black Sea sediments, the second deepest minimum in relative paleointensity during the past 69 ka occurred, with the Laschamp geomagnetic excursion at 41 ka being associated with the lowest field intensities. The field minimum during MIS 4 is associated with large declination swings beginning about 3 ka before the minimum. While a swing to 50°E is associated with steep inclinations (50-60°) according to the coring site at 42°N, the subsequent declination swing to 30°W is associated with shallow inclinations of down to 40°. Nevertheless, these large deviations from the direction of a geocentric axial dipole field (I = 61 °, D = 0 °) still can not yet be termed as 'excursional', since latitudes of corresponding virtual geomagnetic poles (VGP) only reach down to 51.5°N (120°E) and 61.5°N (75°W), respectively. However, these VGP positions at opposite sides of the globe are linked with VGP drift rates of up to 0.2° per year in between. These extreme secular variations might be the mid-latitude expression of a geomagnetic excursion with partly reversed inclinations found at several sites much further North in Arctic

Mediterranean Outflow and surface water variability off southern Portugal during the early Pleistocene: A snapshot at Marine Isotope Stages 29 to 34 (1020-1135 ka)

NASA Astrophysics Data System (ADS)

Voelker, Antje H. L.; Salgueiro, Emilia; Rodrigues, Teresa; Jimenez-Espejo, Francisco J.; Bahr, André; Alberto, Ana; Loureiro, Isabel; Padilha, Maria; Rebotim, Andreia; Röhl, Ursula

2015-10-01

Centennial-to-millennial scale records from IODP Site U1387, drilled during IODP Expedition 339 into the Faro Drift at 558 m water depth, now allow evaluating the climatic history of the upper core of the Mediterranean Outflow (MOW) and of the surface waters in the northern Gulf of Cadiz during the early Pleistocene. This study focuses on the period from Marine Isotope Stages (MIS) 29 to 34, i.e. the interval surrounding extreme interglacial MIS 31. Conditions in the upper MOW reflect obliquity, precession and millennial-scale variations. The benthic δ18O signal follows obliquity with the exception of an additional, smaller δ18O peak that marks the MIS 32/31 transition. Insolation maxima (precession minima) led to poor ventilation and a sluggish upper MOW core, whereas insolation minima were associated with enhanced ventilation and often also increased bottom current velocity. Millennial-scale periods of colder sea-surface temperatures (SST) were associated with short-term maxima in flow velocity and better ventilation, reminiscent of conditions known from MIS 3. A prominent contourite layer, coinciding with insolation cycle 100, was formed during MIS 31 and represents one of the few contourites developing within an interglacial period. MIS 31 surface water conditions were characterized by an extended period (1065-1091 ka) of warm SST, but SST were not much warmer than during MIS 33. Interglacial to glacial transitions experienced 2 to 3 stadial/interstadial cycles, just like their mid-to-late Pleistocene counterparts. Glacial MIS 30 and 32 recorded periods of extremely cold (< 12 °C) SST that in their climatic impact were comparable with the Heinrich events of the mid and late Pleistocene. Glacial MIS 34, on the other hand, was a relative warm glacial period off southern Portugal. Overall, surface water and MOW conditions at Site U1387 show a strong congruence with Mediterranean climate, whereas millennial-scale variations are closely linked to North Atlantic

Early-life stress links 5-hydroxymethylcytosine to anxiety-related behaviors

PubMed Central

Papale, Ligia A.; Madrid, Andy; Li, Sisi; Alisch, Reid S.

2017-01-01

ABSTRACT Environmental stress contributes to the development of psychiatric disorders, including posttraumatic stress disorder and anxiety. While even acute stress alters gene expression, the molecular mechanisms underlying these changes remain largely unknown. 5-hydroxymethylcytosine (5hmC) is a novel environmentally sensitive DNA modification that is highly enriched in the brain and is associated with active transcription of neuronal genes. Here we examined behavioral and molecular alterations in adult mice that experienced an early-life stress before weaning (postnatal day 12 to 18) and found anxiety-like behaviors in adult female mice that were accompanied by correlated disruptions of hypothalamic 5hmC and gene expression in 118 genes, revealing potentially functional 5hmC (i.e., gene regulation). These genes are known and potentially novel stress-related targets, including Nr3c2, Nrxn1, Nfia, and Clip1, that have a significant enrichment for neuronal ontological functions, such as neuronal development and differentiation. Sequence motif predictions indicated that 5hmC may regulate gene expression by mediating transcription factor binding and alternative splicing of many of these transcripts. Together, these findings represent a critical step toward understanding the effects of early environment on the neuromolecular mechanisms that underlie the risk to develop anxiety disorders. PMID:28128679

Early Human Evolution in the Western Palaearctic: Ecological Scenarios

NASA Astrophysics Data System (ADS)

Carrión, José S.; Rose, James; Stringer, Chris

2011-06-01

This review presents the themes of a special issue dealing with environmental scenarios of human evolution during the Early Pleistocene (2.6-0.78 Ma; MIS 103-MIS 19) and early Middle Pleistocene (0.78-0.47 Ma; MIS 19-base of MIS 12) within the western Palaearctic. This period is one of dramatic changes in the climates and the distribution of Palaearctic biota. These changes have played their role in generating adaptive and phyletic patterns within the human ancestry, involving several species such as Homo habilis, "Homo georgicus", Homo erectus, Homo antecessor and Homo heidelbergensis. In the archaeological record, these species include the Oldowan (Mode 1) and Acheulian (Mode 2) lithic technologies. Taphonomic considerations of palaeoecological research in hominin-bearing sites are provided and evaluated. Syntheses are provided for north Africa, western Asia, the Mediterranean Basin, Britain, and continental Europe. Palaeoenvironmental reconstructions based on multidisciplinary data are given for Ain Boucherit, Ain Hanech and El-Kherba in Algeria, Dmanisi in Georgia, Atapuerca, Cueva Negra, and the Orce Basin in Spain, Monte Poggiolo and Pirro Nord in Italy, Pont-de-Lavaud in France, and Mauer in Germany. The state of the art with the Out of Africa 1 dispersal model is reviewed. A source-sink dynamics model for Palaeolithic Europe is described to explain the morphological disparity of H. heidelbergensis (we will sometimes use the informal name "Heidelbergs") and early Neanderthals. Other aspects debated here are the selective value of habitat mosaics including reconstructions based on mammal and avian databases, and the role of geological instability combined with topographic complexity. This review is completed by addressing the question of whether the appearance of evolutionary trends within hominins is concentrated in regions of highest worldwide biological diversity (biodiversity hotspots). It is concluded that the keys for the activation of evolutionary

Mouse chromosomal mapping of a murine leukemia virus integration region (Mis-1) first identified in rat thymic leukemia.

PubMed Central

Jolicoeur, P; Villeneuve, L; Rassart, E; Kozak, C

1985-01-01

We have previously identified a region of genomic DNA which constitutes the site of frequent provirus integration in rat thymomas induced by Moloney murine leukemia virus (Lemay and Jolicoeur, Proc. Natl. Acad. Sci. USA 81:38-42, 1984). This genetic locus is now designated Mis-1 (Moloney integration site). Cellular sequences homologous to Mis-1 are present in mouse DNA. Using a series of hamster-mouse somatic cell hybrids, we mapped the Mis-1 locus to mouse chromosome 15. Frequent chromosome 15 aberrations have been described in mouse thymomas. Mis-1 represents a putative new oncogene which might be involved in the initiation or maintenance or both of these neoplasms. Images PMID:4068142

Transfer RNA: a dancer between charging and mis-charging for protein biosynthesis.

PubMed

Zhou, Xiaolong; Wang, Enduo

2013-10-01

Transfer RNA plays a fundamental role in the protein biosynthesis as an adaptor molecule by functioning as a biological link between the genetic nucleotide sequence in the mRNA and the amino acid sequence in the protein. To perform its role in protein biosynthesis, it has to be accurately recognized by aminoacyl-tRNA synthetases (aaRSs) to generate aminoacyl-tRNAs (aa-tRNAs). The correct pairing between an amino acid with its cognate tRNA is crucial for translational quality control. Production and utilization of mis-charged tRNAs are usually detrimental for all the species, resulting in cellular dysfunctions. Correct aa-tRNAs formation is collectively controlled by aaRSs with distinct mechanisms and/or other trans-factors. However, in very limited instances, mis-charged tRNAs are intermediate for specific pathways or essential components for the translational machinery. Here, from the point of accuracy in tRNA charging, we review our understanding about the mechanism ensuring correct aa-tRNA generation. In addition, some unique mis-charged tRNA species necessary for the organism are also briefly described.

Discriminative power of fatty acid methyl ester (FAME) analysis using the microbial identification system (MIS) for Candida (Torulopsis) glabrata and Saccharomyces cerevisiae.

PubMed

Peltroche-Llacsahuanga, H; Schmidt, S; Lütticken, R; Haase, G

2000-12-01

Candida (Torulopsis) glabrata is frequently isolated in cases of fungal infection and commonly shows acquired or innate fluconazole resistance. Saccharomyces cerevisiae, an emerging opportunistic yeast pathogen, causes serious systemic infections in immunocompromised, and vaginitis and superficial infections in immunocompetent patients. For both species reliable identification in the routine laboratory is mandatory, but species identification of strains, e.g. trehalose-negative C. glabrata, may be difficult. Therefore, gas-liquid chromatography (GLC) of whole cell fatty acid methyl ester (FAME) profiles, that is independent of assimilation profiles of strains and suitable for reliable and rapid identification of clinically important yeasts, was applied. However, frequent misidentification of C. glabrata as S. cerevisiae has been reported when using the Yeast Clinical Database of MIS. Accuracy of MIS identification may be strongly influenced by the amounts of cell mass analyzed. Therefore, the present study compared the MIS results of these two yeasts achieved with different cell masses. Primarily we optimized, especially with respect to cost-effectiveness, the recommended streaking technique yielding a maximal recovery of 90-130 mg of cell mass from one plate, enabling testing of poor growing strains of C. glabrata. For all C. glabrata strains tested (n = 10) the highest identification scores (SI [Similarity Index] range 0.525-0.963, median 0.832) were achieved with 30 to 45 mg of cell mass. Only 5 of 10 S. cerevisiae strains revealed good library comparisons (SI > or = 0.5) when using 30 mg of cell mass, whereas with 45 mg all strains but two revealed this SI-level. For S. cerevisiae a higher amount of cell mass processed (up to 90 mg) was correlated with better identification scores (SI range using 90 mg: 0.464-0.870, median, 0.737). Several passages prior to FAME analysis of C. glabrata strains on recommended media revealed narrowing of SI ranges, but

Latest Early Pleistocene remains of Lynx pardinus (Carnivora, Felidae) from the Iberian Peninsula: Taxonomy and evolutionary implications

NASA Astrophysics Data System (ADS)

Boscaini, Alberto; Alba, David M.; Beltrán, Juan F.; Moyà-Solà, Salvador; Madurell-Malapeira, Joan

2016-07-01

The Iberian lynx (Lynx pardinus) is a critically endangered felid that, during the last fifty years, has been subject to an intensive conservation program in an attempt to save it from extinction. This species is first recorded at ca. 1.7-1.6 Ma (late Villafranchian, late Early Pleistocene) in NE Iberian Peninsula, roughly coinciding with the large faunal turnover that occurred around the middle to late Villafranchian boundary. Here we describe the largest collection of L. pardinus remains available to date from the Iberian late Early Pleistocene (Epivillafranchian), including localities from the Vallparadís Section (Vallès-Penedès Basin, NE Iberian Peninsula) and Cueva Victoria (Cartagena, SE Iberian Peninsula). The morphology and biometry of the studied material attests to the widespread occurrence of L. pardinus in the Mediterranean coast of the Iberian Peninsula since the latest Early Pleistocene, i.e., about 0.5 million years earlier than it was generally accepted (i.e., at the beginning of the Middle Pleistocene). Based on the features observed in the large sample studied in this paper, we conclude that Lynx spelaeus is a junior synonym of L. pardinus and further propose to assign all the Epivillafranchian and younger fossil lynxes from SW Europe to the extant species L. pardinus. Due to the arrival of the Eurasian lynx (Lynx lynx) into Europe at the beginning of the Late Pleistocene, the attribution of specimens younger than MIS 5e to either this species or L. pardinus solely on morphological grounds has proven equivocal. Here we discuss the main diagnostic features of both species of European lynxes and further review their evolutionary history and paleobiogeography throughout the Pleistocene.

Late Pleistocene climate change and landscape dynamics in the Eastern Alps: the inner-alpine Unterangerberg record (Austria)

PubMed Central

Starnberger, Reinhard; Drescher-Schneider, Ruth; Reitner, Jürgen M.; Rodnight, Helena; Reimer, Paula J.; Spötl, Christoph

2013-01-01

Drill cores from the inner-alpine valley terrace of Unterangerberg, located in the Eastern Alps of Austria, offer first insights into a Pleistocene sedimentary record that was not accessible so far. The succession comprises diamict, gravel, sand, lignite and thick, fine grained sediments. Additionally, cataclastic deposits originating from two paleo-landslide events are present. Multi-proxy analyses including sedimentological and palynological investigations as well as radiocarbon and luminescence data record the onset of the last glacial period (Würmian) at Unterangerberg at ∼120–110 ka. This first time period, correlated to the MIS 5d, was characterised by strong fluvial aggradation under cold climatic conditions, with only sparse vegetation cover. Furthermore, two large and quasi-synchronous landslide events occurred during this time interval. No record of the first Early Würmian interstadial (MIS 5c) is preserved. During the second Early Würmian interstadial (MIS 5a), the local vegetation was characterised by a boreal forest dominated by Picea, with few thermophilous elements. The subsequent collapse of the vegetation is recorded by sediments dated to ∼70–60 ka (i.e. MIS 4), with very low pollen concentrations and the potential presence of permafrost. Climatic conditions improved again between ∼55 and 45 ka (MIS 3) and cold-adapted trees re-appeared during interstadials, forming an open forest vegetation. MIS 3 stadials were shorter and less severe than the MIS 4 at Unterangerberg, and vegetation during these cold phases was mainly composed of shrubs, herbs and grasses, similar to what is known from today's alpine timberline. The Unterangerberg record ended at ∼45 ka and/or was truncated by ice during the Last Glacial Maximum. PMID:23805019

The performance review of EEWS(Earthquake Early Warning System) about Gyeongju earthquakes with Ml 5.1 and Ml 5.8 in Korea

NASA Astrophysics Data System (ADS)

Park, Jung-Ho; Chi, Heon-Cheol; Lim, In-Seub; Seong, Yun-Jeong; Park, Jihwan

2017-04-01

EEW(Earthquake Early Warning) service to the public has been officially operated by KMA (Korea Meteorological Administration) from 2015 in Korea. For the KMA's official EEW service, KIGAM has adopted ElarmS from UC Berkeley BSL and modified local magnitude relation, 1-D travel time curves and association procedures with real time waveform from about 201 seismic stations of KMA, KIGAM, KINS and KEPRI. There were two moderate size earthquakes with magnitude Ml 5.1 and Ml 5.8 close to Gyeongju city located at the southeastern part of Korea on Sep. 12. 2016. We have checked the performance of EEWS(Earthquake Early Warning System) named as TrigDB by KIGAM reviewing of these two Gyeongju earthquakes. The nearest station to epicenters of two earthquakes Ml 5.1(35.7697 N, 129.1904 E) and Ml 5.8(35.7632 N, 129.1898 E) was MKL which detected P phases in about 2.1 and 3.6 seconds after the origin times respectively. The first events were issued in 6.3 and 7.0 seconds from each origin time. Because of the unstable results on the early steps due to very few stations and unexpected automated analysis, KMA has the policy to wait for more 20 seconds for confirming the reliability. For these events KMA published EEW alarms in about 26 seconds after origin times with M 5.3 and M 5.9 respectively.

Revisiting Tectonic Corrections Applied to Pleistocene Sea-Level Highstands

NASA Astrophysics Data System (ADS)

Creveling, J. R.; Mitrovica, J. X.; Hay, C.; Austermann, J.; Kopp, R. E.

2015-12-01

The robustness of stratigraphic- and geomorphic-based inferences of Quaternary peak interglacial sea levels — and equivalent minimum continental ice volumes — depends on the accuracy with which highstand markers can be corrected for vertical tectonic displacement. For sites that preserve a Marine Isotope Stage (MIS) 5e sea-level highstand marker, the customary method for estimating tectonic uplift/subsidence rate computes the difference between the local elevation of the highstand marker and a reference eustatic (i.e., global mean) MIS 5e sea-level height, typically assumed to be +6 m, and then divides this height difference by the age of the highstand marker. This rate is then applied to correct the elevation of other observed sea-level markers at that site for tectonic displacement. Subtracting a reference eustatic value from a local MIS 5e highstand marker elevation introduces two potentially significant errors. First, the commonly adopted peak eustatic MIS 5e sea-level value (i.e., +6 m) is likely too low; recent studies concluded that MIS 5e peak eustatic sea level was ~6-9 m. Second, local peak MIS 5e sea level was not globally uniform, but instead characterized by significant departures from eustasy due to glacial isostatic adjustment (GIA) in response to successive glacial-interglacial cycles and excess polar ice-sheet melt relative to present day. We present numerical models of GIA that incorporate both of these effects in order to quantify the plausible range in error of previous tectonic corrections. We demonstrate that, even far from melting ice sheets, local peak MIS 5e sea level may have departed from eustasy by 2-4 m, or more. Thus, adopting an assumed reference eustatic value to estimate tectonic displacement, rather than a site-specific GIA signal, can introduce significant error in estimates of peak eustatic sea level (and minimum ice volumes) during Quaternary highstands (e.g., MIS 11, MIS 5c and MIS 5a).

Suppression in the electrical hysteresis by using CaF2 dielectric layer for p-GaN MIS capacitors

NASA Astrophysics Data System (ADS)

Sang, Liwen; Ren, Bing; Liao, Meiyong; Koide, Yasuo; Sumiya, Masatomo

2018-04-01

The capacitance-voltage (C-V) hysteresis in the bidirectional measurements of the p-GaN metal-insulator-semiconductor (MIS) capacitor is suppressed by using a CaF2 dielectric layer and a post annealing treatment. The density of trapped charge states at the CaF2/p-GaN interface is dramatically reduced from 1.3 × 1013 cm2 to 1.1 × 1011/cm2 compared to that of the Al2O3/p-GaN interface with a large C-V hysteresis. It is observed that the disordered oxidized interfacial layer can be avoided by using the CaF2 dielectric. The downward band bending of p-GaN is decreased from 1.51 to 0.85 eV as a result of the low-density oxides-related trap states. Our work indicates that the CaF2 can be used as a promising dielectric layer for the p-GaN MIS structures.

A high-elevation, multi-proxy biotic and environmental record of MIS 6–4 from the Ziegler Reservoir fossil site, Snowmass Village, Colorado, USA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ian M. Miller; Mitchell A. Plummer; Various Others

In North America, terrestrial records of biodiversity and climate change that span Marine Oxygen Isotope Stage (MIS) 5 are rare. Where found, they provide insight into how the coupling of the ocean–atmosphere system is manifested in biotic and environmental records and how the biosphere responds to climate change. In 2010–2011, construction at Ziegler Reservoir near Snowmass Village, Colorado (USA) revealed a nearly continuous, lacustrine/wetland sedimentary sequence that preserved evidence of past plant communities between ~140 and 55 ka, including all of MIS 5. At an elevation of 2705 m, the Ziegler Reservoir fossil site also contained thousands of well-preserved bonesmore » of late Pleistocene megafauna, including mastodons, mammoths, ground sloths, horses, camels, deer, bison, black bear, coyotes, and bighorn sheep. In addition, the site contained more than 26,000 bones from at least 30 species of small animals including salamanders, otters, muskrats, minks, rabbits, beavers, frogs, lizards, snakes, fish, and birds. The combination of macro- and micro-vertebrates, invertebrates, terrestrial and aquatic plant macrofossils, a detailed pollen record, and a robust, directly dated stratigraphic framework shows that high-elevation ecosystems in the Rocky Mountains of Colorado are climatically sensitive and varied dramatically throughout MIS 5« less

Deglacial hydrography and IRD inputs: A comparison of Terminations I and II in the N.E. Atlantic

NASA Astrophysics Data System (ADS)

Hibbert, Fiona; Chapman, Mark; Austin, William; Rohling, Eelco

2015-04-01

We present a high resolution marine record (MD04-2822) from the N.E. Atlantic. This record captures the demise of the penultimate glaciation (Termination II) in high resolution. The record of co-registered proxies offers the opportunity to investigate the evolution of the last two deglacial events in the North Atlantic. The deglacial evolution of Termination II is much less well documented than the last deglaciation (Termination I). A striking feature of Termination II in the MD04-2822 record, are several large (~1 ‰) oscillations in benthic δ18O, reflecting oscillations in sea level (e.g. Grant et al., 2012, Thomas et al., 2009) and/or deep sea temperatures (cf. Skinner and Shackleton, 2006). Also notable is the markedly different pattern of surface and deep water evolution for the two deglaciations. Termination I is characterised by a short offset between benthic δ18O decrease and δ13C increase (and northwards migration of the polar front) whereas during Termination II, benthic δ13C 'improvement' (and inferred resumption in overturning) occurs only during the Marine Isotope Stage (MIS) 5e plateau, giving the marine record it's characteristic 'drawn-out' appearance. The most conspicuous feature of the penultimate deglacial in most marine cores is Heinrich event 11 (H11), an extensive episode of ice rafted debris (IRD) discharge that spread across the North Atlantic to the margin of what is now the subtropical gyre (Chapman et al., 2000). H11 generally manifests in marine records as one large and long (~ 2.5 ka) event throughout the Termination. In MD04-2822 however, there are multiple IRD events within the Termination. The continued influence of the disintegrating N. hemisphere ice sheets is also evident within the benthic δ13C and surface conditions (the polar front migrates north of the core site early within MIS 5e following a brief SST reversal).

Interactive Learning System "VisMis" for Scientific Visualization Course

ERIC Educational Resources Information Center

Zhu, Xiaoming; Sun, Bo; Luo, Yanlin

2018-01-01

Now visualization courses have been taught at universities around the world. Keeping students motivated and actively engaged in this course can be a challenging task. In this paper we introduce our developed interactive learning system called VisMis (Visualization and Multi-modal Interaction System) for postgraduate scientific visualization course…

Examining the Error of Mis-Specifying Nonlinear Confounding Effect With Application on Accelerometer-Measured Physical Activity.

PubMed

Lee, Paul H

2017-06-01

Some confounders are nonlinearly associated with dependent variables, but they are often adjusted using a linear term. The purpose of this study was to examine the error of mis-specifying the nonlinear confounding effect. We carried out a simulation study to investigate the effect of adjusting for a nonlinear confounder in the estimation of a causal relationship between the exposure and outcome in 3 ways: using a linear term, binning into 5 equal-size categories, or using a restricted cubic spline of the confounder. Continuous, binary, and survival outcomes were simulated. We examined the confounder across varying measurement error. In addition, we performed a real data analysis examining the 3 strategies to handle the nonlinear effects of accelerometer-measured physical activity in the National Health and Nutrition Examination Survey 2003-2006 data. The mis-specification of a nonlinear confounder had little impact on causal effect estimation for continuous outcomes. For binary and survival outcomes, this mis-specification introduced bias, which could be eliminated using spline adjustment only when there is small measurement error of the confounder. Real data analysis showed that the associations between high blood pressure, high cholesterol, and diabetes and mortality adjusted for physical activity with restricted cubic spline were about 3% to 11% larger than their counterparts adjusted with a linear term. For continuous outcomes, confounders with nonlinear effects can be adjusting with a linear term. Spline adjustment should be used for binary and survival outcomes on confounders with small measurement error.

A Detailed Record of Changing Surface Water Conditions From Sediments Deposited During Marine Isotope Stage 11, ODP Site 980, Northeast Atlantic Ocean

NASA Astrophysics Data System (ADS)

Arvin, T. A.; Cullen, J. L.; Oppo, D. W.; McManus, J. F.

2004-05-01

fact that the relative abundance of the polar species N. pachyderma, left coiling, after dropping from near 90% to below 10% at 418 kya, rises to as high as 30% during this early MIS11 time interval. This seems to indicate the influx of non-ice bearing colder polar waters to the region above Site 980 that don't seem to be influencing he N. pachyderma, right coiling isotope record in a simple way. The MIS11 IRD record significantly differs from our records from MIS5e and the Holocene, particularly when we focus on the earliest 12 kyr of MIS11. Both the approximately 10 kyr long MIS5e interval and the last 11 kyr of the Holocene exhibit a series of between 6 and 9 discrete small amplitude increases in IRD against a background of little or no IRD. At the same time relative abundances of N. pachyderma, left coiling are considerably less during both MIS5e and the Holocene when compared to the first 10 kyr of MIS11. The evidence presented here suggests that MIS11 surface water conditions above Site 980 were somewhat different from conditions recorded in sediments from two other warm interglacial intervals, MIS5e and the Holocene and that its use as an ancient analog to modern and future climate may be less straightforward than previously thought.

Pyeloplasty techniques using minimally invasive surgery (MIS) in pediatric patients.

PubMed

Turrà, Francesco; Escolino, Maria; Farina, Alessandra; Settimi, Alessandro; Esposito, Ciro; Varlet, François

2016-10-01

Hydronephrosis is the most common presentation of ureteropelvic junction (UPJ) obstruction. We reviewed literature, collecting data from Medline, to evaluate the current status of minimally invasive surgery (MIS) approach to pyeloplasty. Since the first pyeloplasty was described in 1939, several techniques has been applied to correct UPJ obstruction, but Anderson-Hynes dismembered pyeloplasty is established as the gold standard, to date also in MIS technique. According to literature several studies underline the safety and effectiveness of this approach for both trans- and retro-peritoneal routes, with a success rate between 81-100% and an operative time between 90-228 min. These studies have demonstrated the safety and efficacy of this procedure in the management of UPJ obstruction in children. Whether better the transperitoneal, than the retroperitoneal approach is still debated. A long learning curve is needed especially in suturing and knotting.

Neural circuitry governing anxious individuals' mis-allocation of working memory to threat.

PubMed

Stout, Daniel M; Shackman, Alexander J; Pedersen, Walker S; Miskovich, Tara A; Larson, Christine L

2017-08-18

Dispositional anxiety is a trait-like phenotype that confers increased risk for a range of debilitating neuropsychiatric disorders. Like many patients with anxiety disorders, individuals with elevated levels of dispositional anxiety are prone to intrusive and distressing thoughts in the absence of immediate threat. Recent electrophysiological research suggests that these symptoms are rooted in the mis-allocation of working memory (WM) resources to threat-related information. Here, functional MRI was used to identify the network of brain regions that support WM for faces and to quantify the allocation of neural resources to threat-related distracters in 81 young adults. Results revealed widespread evidence of mis-allocation. This was evident in both face-selective regions of the fusiform cortex and domain-general regions of the prefrontal and parietal cortices. This bias was exaggerated among individuals with a more anxious disposition. Mediation analyses provided compelling evidence that anxious individuals' tendency to mis-allocate WM resources to threat-related distracters is statistically explained by heightened amygdala reactivity. Collectively, these results provide a neurocognitive framework for understanding the pathways linking anxious phenotypes to the development of internalizing psychopathology and set the stage for developing improved intervention strategies.

Effects of ultrathin oxides in conducting MIS structures on GaAs

NASA Technical Reports Server (NTRS)

Childs, R. B.; Ruths, J. M.; Sullivan, T. E.; Fonash, S. J.

1978-01-01

Schottky barrier-type GaAs baseline devices (semiconductor surface etched and then immediately metalized) and GaAs conducting metal oxide-semiconductor devices are fabricated and characterized. The baseline surfaces (no purposeful oxide) are prepared by a basic or an acidic etch, while the surface for the MIS devices are prepared by oxidizing after the etch step. The metallizations used are thin-film Au, Ag, Pd, and Al. It is shown that the introduction of purposeful oxide into these Schottky barrier-type structures examined on n-type GaAs modifies the barrier formation, and that thin interfacial layers can modify barrier formation through trapping and perhaps chemical reactions. For Au- and Pd-devices, enhanced photovoltaic performance of the MIS configuration is due to increased barrier height.

Design and simulation of a novel E-mode GaN MIS-HEMT based on a cascode connection for suppression of electric field under gate and improvement of reliability

NASA Astrophysics Data System (ADS)

Li, Weiyi; Zhang, Zhili; Fu, Kai; Yu, Guohao; Zhang, Xiaodong; Sun, Shichuang; Song, Liang; Hao, Ronghui; Fan, Yaming; Cai, Yong; Zhang, Baoshun

2017-07-01

We proposed a novel AlGaN/GaN enhancement-mode (E-mode) high electron mobility transistor (HEMT) with a dual-gate structure and carried out the detailed numerical simulation of device operation using Silvaco Atlas. The dual-gate device is based on a cascode connection of an E-mode and a D-mode gate. The simulation results show that electric field under the gate is decreased by more than 70% compared to that of the conventional E-mode MIS-HEMTs (from 2.83 MV/cm decreased to 0.83 MV/cm). Thus, with the discussion of ionized trap density, the proposed dual-gate structure can highly improve electric field-related reliability, such as, threshold voltage stability. In addition, compared with HEMT with field plate structure, the proposed structure exhibits a simplified fabrication process and a more effective suppression of high electric field. Project supported by the Key Technologies Support Program of Jiangsu Province (No. BE2013002-2) and the National Key Scientific Instrument and Equipment Development Projects of China (No. 2013YQ470767).

Late Quaternary environmental changes inferred from n-alkane evidence in coastal area of southern Hainan Island, China

NASA Astrophysics Data System (ADS)

Wang, Mengyuan; Zheng, Zhuo

2016-04-01

The studied core was a coastal core in Hainan Island, China. It is in length of 49.01m and divided into four Units (MIS 1~MIS 6) according to lithology description. The Optically Stimulated Luminescence (OSL) attributes the sediments from Unit 3 to the Oxygen Isotope Stage of MIS 5e (Unit 3b and 3c) and 5d (Unit 3a). To interpret the origination of organic carbons and to reconstruct paleovegetation changes, n-alkane, δ13C and TOC have been used in the present research. The result of n-alkanes distribution indicates a series of changes of sedimentary environment and terrestrial input. The shallow water facies at Unit 2, 3a and 4 is mainly characterized by short carbon chain n-alkanes and relatively low concentration. Contrasting with that of deep-water marine facies of MIS 5e (Unit 3b), the n-alkane pattern is typical bimodal and the main peaks are both in short and long carbon chains. During Unit 3b-1 (MIS 5e), more terrestrial original n-alkanes contribute to the concentration of TOC than oceanic. Organic matter source is mainly terrestrial origination. Total organic matter input mechanism of TLG-01 correlates with sediment grain size (average grain size). Total organic carbon input is enhanced with the increasing of fine grain size component. The variation of CPI (25-33) value in this study correlates with hydrological energy. The highest CPI (25-33) value is shown in the high sea level period of MIS 5e, comparing with that in MIS 5d and MIS 1. High CPI value corresponds to high TOC and average grain size (Φ) value. In the weak hydrological energy sedimentary environment, more terrestrial organic matter, together with TOC, deposit in the study area. ACL (25-33) index display higher values in the interglacial period (MIS 5 and MIS 1) than MIS 3 (sediments weathered during MIS 2) and MIS 6. Paq proxy, together with δ13C, estimates the mangrove growing depth in MIS 5e. The correlation between δ13C and each carbon chain alkane state stabilize and turbulence of

The Sexual Function Questionnaire's Medical Impact Scale (SFQ-MIS): validation among a sample of first-time mothers.

PubMed

Jawed-Wessel, Sofia; Schick, Vanessa; Herbenick, Debby

2013-11-01

Changes in sexual function can be difficult to capture, especially when an attempt is made to assess the effects of pregnancy or childbirth on the sexual function of first-time mothers. Commonly used sexual function measures are limited and fail to account for pregnancy or birth in assessment of function. The purpose of this study was to explore the utility of the Sexual Function Questionnaire Medical Impact Scale (SFQ-MIS) in assessing impact of childbirth on sexual function among first-time mothers with infants aged one year or younger. A total of 255 women completed a cross-sectional, web-based survey. Exploratory factor analysis was utilized to assess the factor structure of the SFQ-MIS scores in this sample. Variations in SFQ-MIS scores based upon participant characteristics were conducted to further evaluate the SFQ-MIS scores. SFQ-MIS score was the primary measure of interest. Factors related to pregnancy and childbirth, such as mode of delivery, infant date of birth, last menstrual period, need for an episiotomy or perineal stitches, breastfeeding status, and score on the Perceived Stress Scale, were also assessed in order to further evaluate the validity and predictive capacity of the SFQ-MIS. Results indicated one factor that accounted for 58.27% of the variance in impact on sexual function due to childbirth. Cronbach's α coefficient for all five items was acceptable (0.82). Women who were breastfeeding (P<0.05), those who had received perineal stitches after a vaginal delivery (P<0.05), and those who reported no sexual activity in the past month (P < 0.001) experienced significantly greater impact than those who were not breastfeeding, those who had not required stitches, and those who had been sexually active in the past month. The SFQ-MIS appears to be a useful and valid indicator of changes in sexual function following childbirth, such as those related to arousal, desire, and orgasm. © 2013 International Society for Sexual Medicine.

Individual differences in early adolescents' latent trait cortisol: Interaction of early adversity and 5-HTTLPR.

PubMed

Chen, Frances R; Stroud, Catherine B; Vrshek-Schallhorn, Suzanne; Doane, Leah D; Granger, Douglas A

2017-10-01

The present study aimed to examine the interaction of 5-HTTLPR and early adversity on trait-like levels of cortisol. A community sample of 117 early adolescent girls (M age=12.39years) provided DNA samples for 5-HTTLPR genotyping, and saliva samples for assessing cortisol 3 times a day (waking, 30min post-waking, and bedtime) over a three-day period. Latent trait cortisol (LTC) was modeled using the first 2 samples of each day. Early adversity was assessed with objective contextual stress interviews with adolescents and their mothers. A significant 5-HTTLPR×early adversity interaction indicated that greater early adversity was associated with lower LTC levels, but only among individuals with either L/L or S/L genotype. Findings suggest that serotonergic genetic variation may influence the impact of early adversity on individual differences in HPA-axis regulation. Future research should explore whether this interaction contributes to the development of psychopathology through HPA axis functioning. Copyright © 2017 Elsevier B.V. All rights reserved.

Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a predictor of conversion from mild cognitive impairment to Alzheimer's disease.

PubMed

Julayanont, Parunyou; Brousseau, Mélanie; Chertkow, Howard; Phillips, Natalie; Nasreddine, Ziad S

2014-04-01

To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA-TS) and Memory Index Score (MoCA-MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI). Retrospective chart review. Community-based memory clinic. Individuals meeting Petersen's MCI criteria (N = 165). Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA-TS, MoCA-MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD. One hundred fourteen participants progressed to AD (MCI-AD), and 51 did not (nonconverters; MCI-NC); 90.5% of participants with MCI with a MoCA-TS less than 20/30 and a MoCA-MIS less than 7/15 at baseline converted to AD within the average follow-up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple-domain amnestic MCI had the highest AD conversion rates (73.9%). Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA-TS and a low newly devised memory index score (MoCA-MIS) are at greater risk of short-term conversion to AD. © 2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society.

Magnetic induction spectroscopy (MIS)-probe design for cervical tissue measurements.

PubMed

Wang, Jau-Yi; Healey, Timothy; Barker, Anthony; Brown, Brian; Monk, Chris; Anumba, Dilly

2017-05-01

Gradiometers have the advantage of increasing measuring sensitivity, which is particularly useful in magnetic induction spectroscopy (MIS) for bio-impedance measurements. Traditional gradiometers use a pair of field sensing coils equally distant and on opposite sides of a drive coil, which provides high immunity to interference. In this paper, a ferrite-cored coaxial gradiometer probe of 29 mm diameter has been developed for measuring the impedance spectra of cervical tissues in vivo. It consists of a ferrite rod with outer ferrite confinement screening in order to eliminate the signals from surrounding tissue. The magnetic screening efficiency was compared with an air-cored gradiometer probe. For both gradiometer probes, a drive coil and two sensing coils were wound on a borosilicate glass former aligned coaxially with two sensing coils equidistant from the drive coil. The signal sensitivity of those two MIS gradiometers has been measured using saline samples with a conductivity range between 0.1 and 1.1 S m -1 . Finite element methods using COMSOL Multiphysics have been used to simulate the distribution of sensitivity to conductivity over the face of each probe and with depth. The ferrite-cored probe has a sensitivity confined to the volume defined by the gap between the ferrite core and outer tube of ferrite while the air-cored probe without any magnetic shielding had a wide sensitivity over the face and the side of the probe. Four saline samples and one of distilled water with conductivities from 0.1 to 1.1 S m -1 have been used to make conductivity measurements at frequencies of 50 kHz, 100 kHz, and 300 kHz. The measurement accuracy of the air-cored MIS probe was 0.09 S m -1 at 50 kHz, improving to 0.05 S m -1 at 300 kHz. For the ferrite-cored MIS probe, the measurement accuracy was 0.28 S m -1 at 50 kHz, improving to 0.04 S m -1 at 300 kHz. In vivo measurements on human hand have been performed using both types of gradiometers and the

Early experiences with E-prescribing.

PubMed

Halamka, John

2006-01-01

Most physicians understand that e-prescribing will reduce medical errors and will be perceived by patients as making the prescription process easier. However, they are skeptical about a number of things. They worry whether their office processes will be improved or streamlined; e-prescribing will interface seamlessly with their existing practice management software; training and support will be available; e-prescribing data will be seamlessly transferable to an electronic health record when they implement a more advanced clinical record system for their practice; and if they will achieve a return on investment. Early adopting clinicians in Massachusetts can convince the majority of clinicians to adopt e-prescribing by sharing their motivations for adopting e-prescribing, the challenges that they needed to overcome, the hardware and software requirements, and integration into their office workflow. Finally, interaction with the physicians and practice managers in the audience makes the adoption of e-prescribing seem both reasonable and exciting. Resources such as vendor lists, questions to ask, and hardware and software requirements also need to be readily available and in a form that non-technical staff can read and understand. Physicians who know the "why" would also like to know

Design of a Model Management Information System (MIS) for California's Regional Occupational Centers and Programs. Final Report.

ERIC Educational Resources Information Center

Dick, James C.; And Others

The management information system (MIS) development project for California's Regional Occupational Centers and Programs (ROC/Ps) was conducted in 3 phases over a 12-month period. Phase I involved a literature review and field study to match MIS design features and development strategy with existing conditions in ROC/Ps. A decision support system…

Mapping the MIS Curriculum Based on Critical Skills of New Graduates: An Empirical Examination of IT Professionals

ERIC Educational Resources Information Center

Downey, James P.; McMurtrey, Mark E.; Zeltmann, Steven M.

2008-01-01

MIS curricula research almost always focuses on either curriculum issues or the critical skills required of new MIS graduates, rarely both. This study examines both by determining the critical skills required of new graduates, from the perspective of IT professionals in the field, then uniquely mapping those skills into a comprehensive yet…

A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification.

PubMed

Cenik, Can; Chua, Hon Nian; Singh, Guramrit; Akef, Abdalla; Snyder, Michael P; Palazzo, Alexander F; Moore, Melissa J; Roth, Frederick P

2017-03-01

Introns are found in 5' untranslated regions (5'UTRs) for 35% of all human transcripts. These 5'UTR introns are not randomly distributed: Genes that encode secreted, membrane-bound and mitochondrial proteins are less likely to have them. Curiously, transcripts lacking 5'UTR introns tend to harbor specific RNA sequence elements in their early coding regions. To model and understand the connection between coding-region sequence and 5'UTR intron status, we developed a classifier that can predict 5'UTR intron status with >80% accuracy using only sequence features in the early coding region. Thus, the classifier identifies transcripts with 5 ' proximal- i ntron- m inus-like-coding regions ("5IM" transcripts). Unexpectedly, we found that the early coding sequence features defining 5IM transcripts are widespread, appearing in 21% of all human RefSeq transcripts. The 5IM class of transcripts is enriched for non-AUG start codons, more extensive secondary structure both preceding the start codon and near the 5' cap, greater dependence on eIF4E for translation, and association with ER-proximal ribosomes. 5IM transcripts are bound by the exon junction complex (EJC) at noncanonical 5' proximal positions. Finally, N 1 -methyladenosines are specifically enriched in the early coding regions of 5IM transcripts. Taken together, our analyses point to the existence of a distinct 5IM class comprising ∼20% of human transcripts. This class is defined by depletion of 5' proximal introns, presence of specific RNA sequence features associated with low translation efficiency, N 1 -methyladenosines in the early coding region, and enrichment for noncanonical binding by the EJC. © 2017 Cenik et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

The early anaemia of the premature infant: is there a place for vitamin E supplementation?

PubMed

Conway, S P; Rawson, I; Dear, P R; Shires, S E; Kelleher, J

1986-07-01

1. The efficacy of oral vitamin E supplementation in preventing the early anaemia of the premature infant was assessed in a 10-week double-blind trial. Forty-two babies received either a placebo or 5 or 15 mg supplementary vitamin E/d with oral feeding. No infant received less than the recommended vitamin E:polyunsaturated fatty acid (E:PUFA) value of 0.6. No iron supplement was given. 2. Weekly full blood counts were taken, and plasma vitamin E assay and in vitro haemolysis tests performed on blood sampled on day 1, and also at 6 and 10 weeks of age. All blood withdrawn and transfused and all feeds were documented. 3. Thirty-six (86%) of the babies had a plasma vitamin E level at birth below the accepted adult norm, i.e. less than 5200 micrograms/l. At 6 weeks of age thirty-three (79%) and at 10 weeks thirty-five (83%) of the babies had levels within the normal adult range. No baby showed either clinical or haematological evidence of a vitamin E deficiency state during the trial. 4. It is concluded that in the absence of Fe supplementation and observing the minimum recommended E:PUFA value, contemporary feeding practices allow for the absorption of sufficient vitamin E by the premature baby to prevent the development of an early haemolytic anaemia. 5. No significant relation was found between plasma vitamin E levels and the degree of peroxide haemolysis.

Very Early Colorectal Anastomotic Leakage within 5 Post-operative Days: a More Severe Subtype Needs Relaparatomy

PubMed Central

Li, Yi-Wei; Lian, Peng; Huang, Ben; Zheng, Hong-Tu; Wang, Ming-He; Gu, Wei-Lie; Li, Xin-Xiang; Xu, Ye; Cai, San-Jun

2017-01-01

Early anastomotic leakage (AL), usually defined as leakage within 30 post-operative days, represents a severe entity. However, mounting evidence has indicated that majorities of leakage occur within one week after surgery, making late AL rarity. Here we analyzed 101 consecutive colorectal AL, all of which occurred within 30 post-operative days, during Jan 2013 and Dec 2015 in cancer hospital of Fudan University. AL occurring within 5 post-operative days was defined as very early AL (vE-AL). We evaluated risk factors of vE-AL compared with non-vEAL and correlated with post-leakage peritonitis and need of relaparatomy. We found that AL occurred at median time of 7 days after surgery. 23 cases were vE-AL. Reconstruction of post-peritoneum for mid-low rectal carcinoma significantly reduced incidence of vE-AL compared with non-vE-AL (p = 0.042). Patients with vE-AL was associated with presence of peritonitis (p = 0.031), the latter significantly correlated with increased re-operation rate (p = 6.8E-13). Besides, patients with vE-AL trended to correlate with increased re-operation rate after leakage (p = 0.088). In concludsion, vE-AL occurring within 5 post-operative days represents a severe subtype associated with general peritonitis and need of relaparatomy. PMID:28084305

Mindanao Dome variability over the last 160 kyr: Episodic glacial cooling of the West Pacific Warm Pool

NASA Astrophysics Data System (ADS)

Bolliet, Timothé; Holbourn, Ann; Kuhnt, Wolfgang; Laj, Carlo; Kissel, Catherine; Beaufort, Luc; Kienast, Markus; Andersen, Nils; Garbe-Schönberg, Dieter

2011-02-01

We present sea surface, upper thermocline, and benthic δ18O data, as well as temperature and paleoproductivity proxy data, from the International Marine Global Change Study Program (IMAGES) Core MD06-3067 (6°31‧N, 126°30‧E, 1575 m water depth), located in the western equatorial Pacific Ocean within the flow path of the Mindanao Current. Our records reveal considerable glacial-interglacial and suborbital variability in the Mindanao Dome upwelling over the last 160 kyr. Dome activity generally intensified during glacial intervals resulting in cooler thermocline waters, whereas it substantially declined during interglacials, in particular in the early Holocene and early marine oxygen isotope stage (MIS) 5e, when upwelling waters did not reach the thermocline. During MIS 3 and MIS 2, enhanced surface productivity together with remarkably low SST and low upper ocean thermal contrast provide evidence for episodic glacial upwelling to the surface, whereas transient surface warming marks periodic collapses of the Mindanao Dome upwelling during Heinrich events. We attribute the high variability during MIS 3 and MIS 2 to changes in the El Niño Southern Oscillation state that affected boreal winter monsoonal winds and upper ocean circulation. Glacial upwelling intensified when a strong cyclonic gyre became established, whereas El Niño-like conditions during Heinrich events tended to suppress the cyclonic circulation, reducing Ekman transport. Thus, our findings demonstrate that variations in the Mindanao Dome upwelling are closely linked to the position and intensity of the tropical convection and also reflect far-field influences from the high latitudes.

Impacts of polar ice sheets on the East Asian monsoon during the MIS-13 interglacial

NASA Astrophysics Data System (ADS)

Shi, Feng; Yin, Qiuzhen; Nikolova, Irina; Guo, Zhengtang; Berger, Andre

2017-04-01

Among all the interglacials of the last one million years, Marine Isotope Stage (MIS) 13 has the highest δ18O value over the past 800 ka in the deep-sea sediments. This would indicate that MIS-13 is the coolest interglacial if assuming δ18O mainly represents global ice volume. The Antarctic ice core records show also that MIS-13 is the coolest interglacial over Antarctica with almost the lowest greenhouse gases concentrations (GHG). However, many proxy records from the northern hemisphere (NH) indicate that MIS-13 is at least as warm as or even warmer than the recent interglacials, with extremely strong summer monsoon and a possible melting of Greenland ice sheet. In this study, based on proxy reconstructions, different scenarios regarding the size of the Greenland and Antarctic ice sheets are made, and the response of the East Asian summer monsoon to these scenarios are tested by using the models HadCM3 and LOVECLIM as well as factor separation analysis and under the astronomical and GHG configurations of MIS-13. The results show that the influence of the disappearance of Greenland ice sheet on the surface temperature is quite localized, mainly over the northern high latitudinal regions, however, the influence of the bigger southern Hemisphere (SH) ice sheet on the surface temperature is very global, especially in the southern hemisphere. This ice sheet condition has an impact on the precipitation pattern over tropical-subtropical regions. It causes much more summer precipitation over all the East Asian monsoon region, in consistent with the paleosol record from southern China. The scenario of melted Greenland ice sheet and of larger SH ice sheets provides one of the explanations of the strong monsoon rainfall documented by the proxy data.

Northern Hemisphere Glaciation during the Globally Warm Early Late Pliocene

PubMed Central

De Schepper, Stijn; Groeneveld, Jeroen; Naafs, B. David A; Van Renterghem, Cédéric; Hennissen, Jan; Head, Martin J.; Louwye, Stephen; Fabian, Karl

2013-01-01

The early Late Pliocene (3.6 to ∼3.0 million years ago) is the last extended interval in Earth's history when atmospheric CO2 concentrations were comparable to today's and global climate was warmer. Yet a severe global glaciation during marine isotope stage (MIS) M2 interrupted this phase of global warmth ∼3.30 million years ago, and is seen as a premature attempt of the climate system to establish an ice-age world. Here we propose a conceptual model for the glaciation and deglaciation of MIS M2 based on geochemical and palynological records from five marine sediment cores along a Caribbean to eastern North Atlantic transect. Our records show that increased Pacific-to-Atlantic flow via the Central American Seaway weakened the North Atlantic Current and attendant northward heat transport prior to MIS M2. The consequent cooling of the northern high latitude oceans permitted expansion of the continental ice sheets during MIS M2, despite near-modern atmospheric CO2 concentrations. Sea level drop during this glaciation halted the inflow of Pacific water to the Atlantic via the Central American Seaway, allowing the build-up of a Caribbean Warm Pool. Once this warm pool was large enough, the Gulf Stream–North Atlantic Current system was reinvigorated, leading to significant northward heat transport that terminated the glaciation. Before and after MIS M2, heat transport via the North Atlantic Current was crucial in maintaining warm climates comparable to those predicted for the end of this century. PMID:24349081

Early intervention with tafamidis provides long-term (5.5-year) delay of neurologic progression in transthyretin hereditary amyloid polyneuropathy

PubMed Central

Waddington Cruz, Márcia; Amass, Leslie; Keohane, Denis; Schwartz, Jeffrey; Li, Huihua; Gundapaneni, Balarama

2016-01-01

Abstract Transthyretin hereditary amyloid polyneuropathy, also traditionally known as transthyretin familial amyloid polyneuropathy (ATTR-FAP), is a rare, relentless, fatal hereditary disorder. Tafamidis, an oral, non-NSAID, highly specific transthyretin stabilizer, demonstrated safety and efficacy in slowing neuropathy progression in early-stage ATTRV30M-FAP in a 1.5-year, randomized, double-blind, placebo-controlled trial, and 1-year open-label extension study, with a second long-term open-label extension study ongoing. Subgroup analysis of the effectiveness of tafamidis in the pivotal study and its open-label extensions revealed a relatively cohesive cohort of patients with mild neuropathy (i.e. Neuropathy Impairment Score for Lower Limbs [NIS-LL] ≤ 10) at the start of active treatment. Early treatment with tafamidis for up to 5.5 years (≥1 dose of tafamidis meglumine 20 mg once daily during the original trial or after switching from placebo in its extension) resulted in sustained delay in neurologic progression and long-term preservation of nutritional status in this cohort. Mean (95% CI) changes from baseline in NIS-LL and mBMI were 5.3 (1.6, 9.1) points and −7.8 (−44.3, 28.8) kg/m2 × g/L at 5.5 years, respectively. No new safety issues or side effects were identified. These data represent the longest prospective evaluation of tafamidis to date, confirm a favorable safety profile, and underscore the long-term benefits of early intervention with tafamidis. Trial Registration: ClincalTrials.gov Identifier: NCT00409175, NCT00791492, and NCT00925002. PMID:27494299

Early intervention with tafamidis provides long-term (5.5-year) delay of neurologic progression in transthyretin hereditary amyloid polyneuropathy.

PubMed

Waddington Cruz, Márcia; Amass, Leslie; Keohane, Denis; Schwartz, Jeffrey; Li, Huihua; Gundapaneni, Balarama

2016-09-01

Transthyretin hereditary amyloid polyneuropathy, also traditionally known as transthyretin familial amyloid polyneuropathy (ATTR-FAP), is a rare, relentless, fatal hereditary disorder. Tafamidis, an oral, non-NSAID, highly specific transthyretin stabilizer, demonstrated safety and efficacy in slowing neuropathy progression in early-stage ATTRV30M-FAP in a 1.5-year, randomized, double-blind, placebo-controlled trial, and 1-year open-label extension study, with a second long-term open-label extension study ongoing. Subgroup analysis of the effectiveness of tafamidis in the pivotal study and its open-label extensions revealed a relatively cohesive cohort of patients with mild neuropathy (i.e. Neuropathy Impairment Score for Lower Limbs [NIS-LL] ≤ 10) at the start of active treatment. Early treatment with tafamidis for up to 5.5 years (≥1 dose of tafamidis meglumine 20 mg once daily during the original trial or after switching from placebo in its extension) resulted in sustained delay in neurologic progression and long-term preservation of nutritional status in this cohort. Mean (95% CI) changes from baseline in NIS-LL and mBMI were 5.3 (1.6, 9.1) points and -7.8 (-44.3, 28.8) kg/m 2 × g/L at 5.5 years, respectively. No new safety issues or side effects were identified. These data represent the longest prospective evaluation of tafamidis to date, confirm a favorable safety profile, and underscore the long-term benefits of early intervention with tafamidis. ClincalTrials.gov Identifier: NCT00409175, NCT00791492, and NCT00925002.

Insights into Penultimate Interglacial-Glacial Climate Change on Vegetation History at Lake Van, Turkey

NASA Astrophysics Data System (ADS)

Pickarski, N.; Litt, T.

2017-12-01

A new detailed pollen and oxygen isotope record of the penultimate interglacial-glacial cycle (ca. 250-129 ka; MIS 7-6), has been generated from the sediment core at Lake Van, Turkey. The integration of all available proxies (pollen, microscopic charcoal, δ18Obulk, and XRF) shows three temperate intervals of high effective soil moisture availability. This is evidenced by the predominance of oak steppe-forested landscapes similar to the present interglacial vegetation in this sensitive semiarid region. The wettest/warmest stage, as indicated by highest temperate tree percentages, can be broadly correlated with MIS 7c, while the amplitude of the tree population maximum during the oldest penultimate interglacial (MIS 7e) appears to be reduced due to warm but drier climatic conditions. A detailed comparison of the penultimate interglacial complex (MIS 7) to the last interglacial (MIS 5e) and the current interglacial (MIS 1) provides a vivid illustration of possible differences in the successive climatic cycles. Intervening periods of treeless vegetation (MIS 7d, 7a) were predominated by steppe elements. The occurrence of Artemisia and Chenopodiaceae during MIS 7d indicates very dry and cold climatic conditions, while higher temperate tree percentages (mainly deciduous Quercus) points to relatively humid and mild conditions throughout MIS 7b. Despite the general dominance of dry and cold desert-steppe vegetation during the penultimate glacial (MIS 6), this period can be divided into two parts: an early stage (ca. 193-157 ka) with higher oscillations in tree percentages and a later stage (ca. 157-131 ka) with lower tree percentages and subdued oscillations. Furthermore, we are able to identify the MIS 6e event (ca. 179-159 ka), which reveals clear climate variability due to rapid alternation in the vegetation cover. In comparison with long European pollen archives, speleothem isotope records from the Near East, and global climate parameters, the new high

Technological variability during the Early Middle Palaeolithic in Western Europe. Reduction systems and predetermined products at the Bau de l'Aubesier and Payre (South-East France)

PubMed Central

Carmignani, Leonardo; Fernandes, Paul; Wilson, Lucy

2017-01-01

The study of the lithic assemblages of two French sites, the Bau de l’Aubesier and Payre, contributes new knowledge of the earliest Neanderthal techno-cultural variability. In this paper we present the results of a detailed technological analysis of Early Middle Palaeolithic lithic assemblages of MIS 8 and 7 age from the two sites, which are located on opposite sides of the Rhône Valley in the south-east of France. The MIS 9–7 period is considered in Europe to be a time of new behaviours, especially concerning lithic strategies. The shift from the Lower Palaeolithic to the Early Middle Palaeolithic is “classically” defined by an increase in the number of core technologies, including standardized ones, which are stabilized in the full Middle Palaeolithic (MIS 5–3), associated with the decline of the “Acheulean” biface. Applying a common technological approach to the analysis of the two assemblages highlights their technological variability with respect to reduction systems and end products. Differences between Payre and the Bau de l’Aubesier concerning raw material procurement and faunal exploitation only partially explain this multifaceted technological variability, which in our opinion also reflects the existence of distinct technological strategies within the same restricted geographic area, which are related to distinct traditions, site uses, and/or as yet unknown parameters. PMID:28591159

Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila

PubMed Central

Werz, Christian; Lee, Tom V.; Lee, Peter L.; Lackey, Melinda; Bolduc, Clare; Stein, David S.; Bergmann, Andreas

2009-01-01

Summary Incorrectly specified or mis-specified cells often undergo cell death or are transformed to adopt a different cell fate during development. The underlying cause for this distinction is largely unknown. In many developmental mutants in Drosophila, large numbers of mis-specified cells die synchronously, providing a convenient model for analysis of this phenomenon. The maternal mutant bicoid is particularly useful model with which to address this issue because its mutant phenotype is a combination of both transformation of tissue (acron to telson) and cell death in the presumptive head and thorax regions. We show that a subset of these mis-specified cells die through an active gene-directed process involving transcriptional upregulation of the cell death inducer hid. Upregulation of hid also occurs in oskar mutants and other segmentation mutants. In hid bicoid double mutants, mis-specified cells in the presumptive head and thorax survive and continue to develop, but they are transformed to adopt a different cell fate. We provide evidence that the terminal torso signaling pathway protects the mis-specified telson tissue in bicoid mutants from hid-induced cell death, whereas mis-specified cells in the head and thorax die, presumably because equivalent survival signals are lacking. These data support a model whereby mis-specification can be tolerated if a survival pathway is provided, resulting in cellular transformation. PMID:16280349

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

PubMed Central

Janssen, Aniek; Kops, Geert J. P. L.; Medema, René H.

2009-01-01

The mitotic checkpoint has evolved to prevent chromosome mis-segregations by delaying mitosis when unattached chromosomes are present. Inducing severe chromosome segregation errors by ablating the mitotic checkpoint causes cell death. Here we have analyzed the consequences of gradual increases in chromosome segregation errors on the viability of tumor cells and normal human fibroblasts. Partial reduction of essential mitotic checkpoint components in four tumor cell lines caused mild chromosome mis-segregations, but no lethality. These cells were, however, remarkably more sensitive to low doses of taxol, which enhanced the amount and severity of chromosome segregation errors. Sensitization to taxol was achieved by reducing levels of Mps1 or BubR1, proteins having dual roles in checkpoint activation and chromosome alignment, but not by reducing Mad2, functioning solely in the mitotic checkpoint. Moreover, we find that untransformed human fibroblasts with reduced Mps1 levels could not be sensitized to sublethal doses of taxol. Thus, targeting the mitotic checkpoint and chromosome alignment simultaneously may selectively kill tumor cells by enhancing chromosome mis-segregations. PMID:19855003

A Perspective on a Management Information Systems (MIS) Program Review

ERIC Educational Resources Information Center

Yew, Bee K.

2008-01-01

This paper highlights relevant curriculum issues that were identified in a Management Information Systems (MIS) program review undertaken by a group of business faculty in a small regional university. The program review was initiated to improve job marketability of graduates and student enrollment. The review process is described as a collective…

Validation of the three web quality dimensions of a minimally invasive surgery e-learning platform.

PubMed

Ortega-Morán, Juan Francisco; Pagador, J Blas; Sánchez-Peralta, Luisa Fernanda; Sánchez-González, Patricia; Noguera, José; Burgos, Daniel; Gómez, Enrique J; Sánchez-Margallo, Francisco M

2017-11-01

E-learning web environments, including the new TELMA platform, are increasingly being used to provide cognitive training in minimally invasive surgery (MIS) to surgeons. A complete validation of this MIS e-learning platform has been performed to determine whether it complies with the three web quality dimensions: usability, content and functionality. 21 Surgeons participated in the validation trials. They performed a set of tasks in the TELMA platform, where an e-MIS validity approach was followed. Subjective (questionnaires and checklists) and objective (web analytics) metrics were analysed to achieve the complete validation of usability, content and functionality. The TELMA platform allowed access to didactic content with easy and intuitive navigation. Surgeons performed all tasks with a close-to-ideal number of clicks and amount of time. They considered the design of the website to be consistent (95.24%), organised (90.48%) and attractive (85.71%). Moreover, they gave the content a high score (4.06 out of 5) and considered it adequate for teaching purposes. The surgeons scored the professional language and content (4.35), logo (4.24) and recommendations (4.20) the highest. Regarding functionality, the TELMA platform received an acceptance of 95.24% for navigation and 90.48% for interactivity. According to the study, it seems that TELMA had an attractive design, innovative content and interactive navigation, which are three key features of an e-learning platform. TELMA successfully met the three criteria necessary for consideration as a website of quality by achieving more than 70% of agreements regarding all usability, content and functionality items validated; this constitutes a preliminary requirement for an effective e-learning platform. However, the content completeness, authoring tool and registration process required improvement. Finally, the e-MIS validity methodology used to measure the three dimensions of web quality in this work can be applied to other

Glacial-interglacial variations in sediment organic carbon accumulation and benthic foraminiferal assemblages on the Bermuda Rise (ODP Site 1063) during MIS 13 to 10

NASA Astrophysics Data System (ADS)

Poli, Maria Serena; Meyers, Philip A.; Thunell, Robert C.; Capodivacca, Marco

2012-09-01

We have determined organic carbon concentrations and isotopic compositions and benthic foraminiferal assemblages in sediments deposited between ˜500 and 340 ka at ODP Site 1063 on the northeastern flank of the Bermuda Rise. This time interval includes Marine Isotope Stage (MIS) 11, a particularly warm and long interglacial that was similar to today, and MIS 12, one of the most severe glacials of the last 600 kyr. During MIS 11.3, the peak of interglacial warming, organic carbon accumulation rates are low and benthic foraminiferal assemblages are dominated by Nuttallides umbonifera, a species indicative of oligotrophic environments. Higher accumulation rates during MIS 12 and 10 correspond with elevated sedimentation rates (33-36 cm/kyr). This pattern implies a combination of enhanced delivery and improved preservation of sediment organic matter during these glacial times. Organic δ13C values are less negative during MIS 12 and MIS 10 than during MIS 11, which is consistent with greater glacial-stage marine productivity. High relative abundances ofOridorsalis umbonatus during glacial intervals probably records a low but sustained flux of highly degraded organic material. Large, recurrent fluctuations in the abundance of Epistominella exiguaat the beginnings of the MIS 12 and MIS 10 glaciations suggest a marked increase in local phytoplankton blooms at these times and consequent delivery of phytodetritus to the seafloor. The most likely causes of these variations are changes in the position and strength of the Gulf Stream and its associated cold-ring eddies, combined with increased advection of terrigenous sediments from northerly locations during glacial lowstands.

A comparison of registration errors with imageless computer navigation during MIS total knee arthroplasty versus standard incision total knee arthroplasty: a cadaveric study.

PubMed

Davis, Edward T; Pagkalos, Joseph; Gallie, Price A M; Macgroarty, Kelly; Waddell, James P; Schemitsch, Emil H

2015-01-01

Optimal component alignment in total knee arthroplasty has been associated with better functional outcome as well as improved implant longevity. The ability to align components optimally during minimally invasive (MIS) total knee replacement (TKR) has been a cause of concern. Computer navigation is a useful aid in achieving the desired alignment although it is limited by the error during the manual registration of landmarks. Our study aims to compare the registration process error between a standard and a MIS surgical approach. We hypothesized that performing the registration error via an MIS approach would increase the registration process error. Five fresh frozen lower limbs were routinely prepared and draped. The registration process was performed through an MIS approach. This was then extended to the standard approach and the registration was performed again. Two surgeons performed the registration process five times with each approach. Performing the registration process through the MIS approach was not associated with higher error compared to the standard approach in the alignment parameters of interest. This rejects our hypothesis. Image-free navigated MIS TKR does not appear to carry higher risk of component malalignment due to the registration process error. Navigation can be used during MIS TKR to improve alignment without reduced accuracy due to the approach.

Sedimentary architecture and chronostratigraphy of a late Quaternary incised-valley fill: A case study of the late Middle and Late Pleistocene Rhine system in the Netherlands

NASA Astrophysics Data System (ADS)

Peeters, J.; Busschers, F. S.; Stouthamer, E.; Bosch, J. H. A.; Van den Berg, M. W.; Wallinga, J.; Versendaal, A. J.; Bunnik, F. P. M.; Middelkoop, H.

2016-01-01

This paper describes the sedimentary architecture, chronostratigraphy and palaeogeography of the late Middle and Late Pleistocene (Marine Isotope Stage/MIS 6-2) incised Rhine-valley fill in the central Netherlands based on six geological transects, luminescence dating, biostratigraphical data and a 3D geological model. The incised-valley fill consists of a ca. 50 m thick and 10-20 km wide sand-dominated succession and includes a well-developed sequence dating from the Last Interglacial: known as the Eemian in northwest Europe. The lower part of the valley fill contains coarse-grained fluvio-glacial and fluvial Rhine sediments that were deposited under Late Saalian (MIS 6) cold-climatic periglacial conditions and during the transition into the warm Eemian interglacial (MIS 5e-d). This unit is overlain by fine-grained fresh-water flood-basin deposits, which are transgressed by a fine-grained estuarine unit that formed during marine high-stand. This ca. 10 m thick sequence reflects gradual drowning of the Eemian interglacial fluvial Rhine system and transformation into an estuary due to relative sea-level rise. The chronological data suggests a delay in timing of regional Eemian interglacial transgression and sea-level high-stand of several thousand years, when compared to eustatic sea-level. As a result of this glacio-isostatic controlled delay, formation of the interglacial lower deltaic system took only place for a relative short period of time: progradation was therefore limited. During the cooler Weichselian Early Glacial period (MIS 5d-a) deposition of deltaic sediments continued and extensive westward progradation of the Rhine system occurred. Major parts of the Eemian and Weichselian Early Glacial deposits were eroded and buried as a result of sea-level lowering and climate cooling during the early Middle Weichselian (MIS 4-3). Near complete sedimentary preservation occurred along the margins of the incised valley allowing the detailed reconstruction presented

Luminance compensation for AMOLED displays using integrated MIS sensors

NASA Astrophysics Data System (ADS)

Vygranenko, Yuri; Fernandes, Miguel; Louro, Paula; Vieira, Manuela

2017-05-01

Active-matrix organic light-emitting diodes (AMOLEDs) are ideal for future TV applications due to their ability to faithfully reproduce real images. However, pixel luminance can be affected by instability of driver TFTs and aging effect in OLEDs. This paper reports on a pixel driver utilizing a metal-insulator-semiconductor (MIS) sensor for luminance control of the OLED element. In the proposed pixel architecture for bottom-emission AMOLEDs, the embedded MIS sensor shares the same layer stack with back-channel etched a Si:H TFTs to maintain the fabrication simplicity. The pixel design for a large-area HD display is presented. The external electronics performs image processing to modify incoming video using correction parameters for each pixel in the backplane, and also sensor data processing to update the correction parameters. The luminance adjusting algorithm is based on realistic models for pixel circuit elements to predict the relation between the programming voltage and OLED luminance. SPICE modeling of the sensing part of the backplane is performed to demonstrate its feasibility. Details on the pixel circuit functionality including the sensing and programming operations are also discussed.

Constraining early and interacting dark energy with gravitational wave standard sirens: the potential of the eLISA mission

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caprini, Chiara; Tamanini, Nicola, E-mail: chiara.caprini@cea.fr, E-mail: nicola.tamanini@cea.fr

We perform a forecast analysis of the capability of the eLISA space-based interferometer to constrain models of early and interacting dark energy using gravitational wave standard sirens. We employ simulated catalogues of standard sirens given by merging massive black hole binaries visible by eLISA, with an electromagnetic counterpart detectable by future telescopes. We consider three-arms mission designs with arm length of 1, 2 and 5 million km, 5 years of mission duration and the best-level low frequency noise as recently tested by the LISA Pathfinder. Standard sirens with eLISA give access to an intermediate range of redshift 1 ∼< zmore » ∼< 8, and can therefore provide competitive constraints on models where the onset of the deviation from ΛCDM (i.e. the epoch when early dark energy starts to be non-negligible, or when the interaction with dark matter begins) occurs relatively late, at z ∼< 6. If instead early or interacting dark energy is relevant already in the pre-recombination era, current cosmological probes (especially the cosmic microwave background) are more efficient than eLISA in constraining these models, except possibly in the interacting dark energy model if the energy exchange is proportional to the energy density of dark energy.« less

Structures of the Oligosaccharides of the Glycoprotein Coded by Early Region E3 of Adenovirus 2

PubMed Central

Kornfeld, Rosalind; Wold, William S. M.

1981-01-01

Early region E3 of adenovirus 2 encodes a glycoprotein, E3-gp25K, that is a good model with which to study structure-function relationships in transmembrane glycoproteins. We have determined the structures of the oligosaccharides linked to E3-gp25K. The oligosaccharides were labeled with [2-3H]mannose in adenovirus 2-early infected KB cells for 5.5h (pulse) or for 5.5 h followed by a 3-h chase (pulse-chase). E3-gp25K was extracted and purified by chromatography on DEAE-Sephacel in 7 M urea, followed by gel filtration on a column of Bio-Gel A-1.5m in 6 M guanidine hydrochloride. An analysis of the purified protein by sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that it was >95% pure. The oligosaccharides were isolated by pronase digestion followed by gel filtration on a column of Bio-Gel P-6, then by digestion with endo-β-N-acetylglucosaminidase H, followed by gel filtration on Bio-Gel P-6, and finally by paper chromatography. The pulse sample contained equal amounts of Man9GlcNAc and Man8GlcNAc and small amounts of Man7GlcNAc and Man6GlcNAc. The pulse-chase sample had predominantly Man8GlcNAc and much less Man9GlcNAc, indicating that processing of the Man9GlcNAc to Man8GlcNAc had occurred during the chase period. Thus, Man8GlcNAc is the major oligosaccharide on mature E3-gp25K. The structures of these oligosaccharides were established by digestion with α-mannosidase, methylation analysis, and acetolysis. The oligosaccharides found had typical high-mannose structures that have been observed in other membrane and soluble glycoproteins, and the branching patterns and linkages of the mannose residues of Man9GlcNAc were identical to those of the lipid-linked Glc3Man9GlcNAc2 donor. Thus, adenovirus 2 infection (early stages) apparently does not affect the usual cellular high-mannose glycosylation pathways, and despite being virus coded, E3-gp25K is glycosylated in the same manner as a typical mammalian cell-coded glycoprotein. Images PMID:7321093

Structures of the oligosaccharides of the glycoprotein coded by early region E3 of adenovirus 2.

PubMed

Kornfeld, R; Wold, W S

1981-11-01

Early region E3 of adenovirus 2 encodes a glycoprotein, E3-gp25K, that is a good model with which to study structure-function relationships in transmembrane glycoproteins. We have determined the structures of the oligosaccharides linked to E3-gp25K. The oligosaccharides were labeled with [2-(3)H]mannose in adenovirus 2-early infected KB cells for 5.5h (pulse) or for 5.5 h followed by a 3-h chase (pulse-chase). E3-gp25K was extracted and purified by chromatography on DEAE-Sephacel in 7 M urea, followed by gel filtration on a column of Bio-Gel A-1.5m in 6 M guanidine hydrochloride. An analysis of the purified protein by sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that it was >95% pure. The oligosaccharides were isolated by pronase digestion followed by gel filtration on a column of Bio-Gel P-6, then by digestion with endo-beta-N-acetylglucosaminidase H, followed by gel filtration on Bio-Gel P-6, and finally by paper chromatography. The pulse sample contained equal amounts of Man(9)GlcNAc and Man(8)GlcNAc and small amounts of Man(7)GlcNAc and Man(6)GlcNAc. The pulse-chase sample had predominantly Man(8)GlcNAc and much less Man(9)GlcNAc, indicating that processing of the Man(9)GlcNAc to Man(8)GlcNAc had occurred during the chase period. Thus, Man(8)GlcNAc is the major oligosaccharide on mature E3-gp25K. The structures of these oligosaccharides were established by digestion with alpha-mannosidase, methylation analysis, and acetolysis. The oligosaccharides found had typical high-mannose structures that have been observed in other membrane and soluble glycoproteins, and the branching patterns and linkages of the mannose residues of Man(9)GlcNAc were identical to those of the lipid-linked Glc(3)Man(9)GlcNAc(2) donor. Thus, adenovirus 2 infection (early stages) apparently does not affect the usual cellular high-mannose glycosylation pathways, and despite being virus coded, E3-gp25K is glycosylated in the same manner as a typical mammalian cell

PRMT5 is essential for the eIF4E-mediated 5′-cap dependent translation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lim, Ji-Hong; Lee, Yoon-Mi; Lee, Gibok

2014-10-03

Highlights: • PRMT5 participates in syntheses of HIF-1α, c-Myc and cyclin D1 proteins. • PRMT5 promotes the 5′-cap dependent translation. • PRMT5 is required for eIF4E binding to mRNA 5′-cap. • PRMT5 is essential for eIF4E-dependent cell proliferation. - Abstract: It is becoming clear that PRMT5 plays essential roles in cell cycle progression, survival, and responses to external stresses. However, the precise mechanisms underlying such roles of PRMT5 have not been clearly understood. Previously, we have demonstrated that PRMT5 participates in cellular adaptation to hypoxia by ensuring 5′-cap dependent translation of HIF-1α. Given that c-Myc and cyclin D1 expressions aremore » also tightly regulated in 5′-cap dependent manner, we here tested the possibility that PRMT5 promotes cell proliferation by increasing de novo syntheses of the oncoproteins. c-Myc and cyclin D1 were found to be noticeably downregulated by PRMT5 knock-down. A RNA immunoprecipitation analysis, which can identify RNA–protein interactions, showed that PRMT5 is required for the interaction among eIF4E and 5′-UTRs of HIF-1α, c-Myc and cyclin D1 mRNAs. In addition, PRMT5 knock-down inhibited cell proliferation by inducing cell cycle arrest at the G1 phase. More importantly, ectopic expression of eIF4E significantly rescued the cell cycle progression and cell proliferation even in PRMT5-deficeint condition. Based on these results, we propose that PRMT5 determines cell fate by regulating 5′-cap dependent translation of proteins essential for proliferation and survival.« less

Pathway to Independence: Implications for Developing A Sustainable MIS Program in low Resource settings.

PubMed

Mobolaji, Oludara; Fiemu, Nwariaku; Akanmu, Ibrahim; Kish, Pursnani; Omolara, Williams; Foluso, Omodele; Roland, Osuoji; Stephen, Ikuerowo; Adebimpe, Aderounmu

2013-01-01

Gastrointestinal surgery has been at the forefront of advances in minimally invasive surgery (MIS). In the low resource settings of the developing countries, despite the benefits of MIS, its uptake in sub-Saharan African countries has been slow. The present study reports the process of developing a minimally-invasive surgery service line as well as surgical outcomes in LASUTH. METHODS. We reviewed medical records of all patients who underwent minimally invasive surgery at LASUTH between March 2011 and March 2012. During each of three training missions in LASUTH patients with Gastrointestinal and gynaecological surgical conditions were carefully selected, and prepared for surgery. All patients were admitted a day prior to surgery. A description of the surgical technique and the skills training used is also presented. A total of 24 laparoscopic procedures were performed between March 2011 and March 2012. There were more females 17(70.8%) than males 7(29.2%), with a female to male ratio of 2.5:1. The age range was from 18 yrs to 75 yrs with a peak in the age group between 21-30 yrs. The chief complaints were right hypochondrial pain in 9 cases (37.5%) and right iliac fossa pain in 6 cases (25%) whilst others were right groin swelling, dysphagia, infertility and intersex state. The results presented in respect of conversion rate, length of post operative stay and complications rate are similar to the pattern in more established centers. The use of team training as done in LASUTH helps to accelerate the rate of learning and ensures sustainability.

Summary of the Snowmastodon Project Special Volume. A high-elevation, multi-proxy biotic and environmental record of MIS 6-4 from the Ziegler Reservoir fossil site, Snowmass Village, Colorado, USA

NASA Astrophysics Data System (ADS)

Miller, Ian M.; Pigati, Jeffrey S.; Scott Anderson, R.; Johnson, Kirk R.; Mahan, Shannon A.; Ager, Thomas A.; Baker, Richard G.; Blaauw, Maarten; Bright, Jordon; Brown, Peter M.; Bryant, Bruce; Calamari, Zachary T.; Carrara, Paul E.; Cherney, Michael D.; Demboski, John R.; Elias, Scott A.; Fisher, Daniel C.; Gray, Harrison J.; Haskett, Danielle R.; Honke, Jeffrey S.; Jackson, Stephen T.; Jiménez-Moreno, Gonzalo; Kline, Douglas; Leonard, Eric M.; Lifton, Nathaniel A.; Lucking, Carol; Gregory McDonald, H.; Miller, Dane M.; Muhs, Daniel R.; Nash, Stephen E.; Newton, Cody; Paces, James B.; Petrie, Lesley; Plummer, Mitchell A.; Porinchu, David F.; Rountrey, Adam N.; Scott, Eric; Sertich, Joseph J. W.; Sharpe, Saxon E.; Skipp, Gary L.; Strickland, Laura E.; Stucky, Richard K.; Thompson, Robert S.; Wilson, Jim

2014-11-01

In North America, terrestrial records of biodiversity and climate change that span Marine Oxygen Isotope Stage (MIS) 5 are rare. Where found, they provide insight into how the coupling of the ocean-atmosphere system is manifested in biotic and environmental records and how the biosphere responds to climate change. In 2010-2011, construction at Ziegler Reservoir near Snowmass Village, Colorado (USA) revealed a nearly continuous, lacustrine/wetland sedimentary sequence that preserved evidence of past plant communities between ~ 140 and 55 ka, including all of MIS 5. At an elevation of 2705 m, the Ziegler Reservoir fossil site also contained thousands of well-preserved bones of late Pleistocene megafauna, including mastodons, mammoths, ground sloths, horses, camels, deer, bison, black bear, coyotes, and bighorn sheep. In addition, the site contained more than 26,000 bones from at least 30 species of small animals including salamanders, otters, muskrats, minks, rabbits, beavers, frogs, lizards, snakes, fish, and birds. The combination of macro- and micro-vertebrates, invertebrates, terrestrial and aquatic plant macrofossils, a detailed pollen record, and a robust, directly dated stratigraphic framework shows that high-elevation ecosystems in the Rocky Mountains of Colorado are climatically sensitive and varied dramatically throughout MIS 5.

Accounting Early for Life Long Learning: The AcE Project.

ERIC Educational Resources Information Center

University Coll. Worcester (England). Centre for Research in Early Childhood Education.

Building upon the work of the Effective Early Learning (EEL) Project in raising the quality of early learning for young children in the United Kingdom, the 3-year Accounting Early for Life Long Learning Project (AcE Project) focuses on enhancing in 3- to 6-year-olds those attitudes and dispositions that are important to life-long learning. This…

Paleosols in low-order streams and valley heads in the Araucaria Plateau - Record of continental environmental conditions in southern Brazil at the end of MIS 3

NASA Astrophysics Data System (ADS)

Paisani, Julio Cesar; Pontelli, Marga Eliz; Osterrieth, Margarita Luisa; Paisani, Sani Daniela Lopes; Fachin, Andressa; Guerra, Simone; Oliveira, Leandro

2014-10-01

pedogeochemical process during MIS 3; c) during this period, the water regime was sufficiently humid to develop hydromorphic horizons in the valley bottoms of the entire drainage network to the valley heads; d) regional change toward a drier hydric regime occurred in MIS 2, when erosion of the paleosols predominated; and e) in MIS 1 (current Holocene interglacial), burial of the paleosols and relief inversion occurred, which resulted in fossilization of the valleys.

49 CFR Appendix H to Part 40 - DOT Drug and Alcohol Testing Management Information System (MIS) Data Collection Form

Code of Federal Regulations, 2010 CFR

2010-10-01

..., App. H Appendix H to Part 40—DOT Drug and Alcohol Testing Management Information System (MIS) Data... 49 Transportation 1 2010-10-01 2010-10-01 false DOT Drug and Alcohol Testing Management Information System (MIS) Data Collection Form H Appendix H to Part 40 Transportation Office of the Secretary...

49 CFR Appendix H to Part 40 - DOT Drug and Alcohol Testing Management Information System (MIS) Data Collection Form

Code of Federal Regulations, 2013 CFR

2013-10-01

..., App. H Appendix H to Part 40—DOT Drug and Alcohol Testing Management Information System (MIS) Data... 49 Transportation 1 2013-10-01 2013-10-01 false DOT Drug and Alcohol Testing Management Information System (MIS) Data Collection Form H Appendix H to Part 40 Transportation Office of the Secretary...

49 CFR Appendix H to Part 40 - DOT Drug and Alcohol Testing Management Information System (MIS) Data Collection Form

Code of Federal Regulations, 2014 CFR

2014-10-01

..., App. H Appendix H to Part 40—DOT Drug and Alcohol Testing Management Information System (MIS) Data... 49 Transportation 1 2014-10-01 2014-10-01 false DOT Drug and Alcohol Testing Management Information System (MIS) Data Collection Form H Appendix H to Part 40 Transportation Office of the Secretary...

49 CFR Appendix H to Part 40 - DOT Drug and Alcohol Testing Management Information System (MIS) Data Collection Form

Code of Federal Regulations, 2012 CFR

2012-10-01

..., App. H Appendix H to Part 40—DOT Drug and Alcohol Testing Management Information System (MIS) Data... 49 Transportation 1 2012-10-01 2012-10-01 false DOT Drug and Alcohol Testing Management Information System (MIS) Data Collection Form H Appendix H to Part 40 Transportation Office of the Secretary...

49 CFR Appendix H to Part 40 - DOT Drug and Alcohol Testing Management Information System (MIS) Data Collection Form

Code of Federal Regulations, 2011 CFR

2011-10-01

..., App. H Appendix H to Part 40—DOT Drug and Alcohol Testing Management Information System (MIS) Data... 49 Transportation 1 2011-10-01 2011-10-01 false DOT Drug and Alcohol Testing Management Information System (MIS) Data Collection Form H Appendix H to Part 40 Transportation Office of the Secretary...

Interface properties of MIS structures based on hetero-epitaxial graded-gap Hg1-xCdxTe with CdTe interlayer created in situ during MBE growth

NASA Astrophysics Data System (ADS)

Voitsekhovskii, Alexander V.; Nesmelov, Sergey N.; Dzyadukh, Stanislav M.; Varavin, Vasily S.; Dvoretsky, Sergey A.; Mikhailov, Nikolay N.; Yakushev, Maksim V.; Sidorov, Georgy Yu.

2017-11-01

Heterostructures based on n-Hg1-xCdxTe (x = 0.23-0.40) with near-surface graded-gap layers were grown by molecular beam epitaxy on Si (013) substrates. At 77 K, the admittance of the In/Al2O3/Hg1-xCdxTe metal-insulator-semiconductor (MIS) structures with grown in situ CdTe intermediate layer and without such a layer was investigated. It has been established that MIS structures of In/Al2O3/Hg1-xCdxTe with an interlayer of in situ grown CdTe are characterized by the electrical strength of the dielectric and the qualitative interface. The hysteresis of the capacitive characteristics is practically absent within a small range of variation in the bias voltage. The density of fast surface states at the minimum does not exceed 2.2 × 1010 eV-1 cm-2. MIS structures of In/Al2O3/Hg1-xCdxTe without an intermediate layer of CdTe have significantly higher densities of fast and slow surface states, as well as lower values of the differential resistance of the space-charge region in the regime of strong inversion.

Glacial origin for cave rhythmite during MIS 5d-c in a glaciokarst landscape, Picos de Europa (Spain)

NASA Astrophysics Data System (ADS)

Ballesteros, Daniel; Jiménez-Sánchez, Montserrat; Giralt, Santiago; DeFelipe, Irene; García-Sansegundo, Joaquín

2017-06-01

Laminated slackwater deposits have been identified in many karst caves related to fluvial and lacustrine sedimentation. However, sedimentological evidence rarely supports a glacial origin for these deposits, which was proposed by previous studies. The Torca La Texa shaft is located in a glaciokarst area that comprises numerous slackwater-type deposits, piled up in fining-upward sequences. A basal sandy erosive layer and millimeter-sized laminated rhythmite with interbedded flowstone characterize these sequences. Fining-upward layers of carbonate silt, clay, and minor quartz sand deposited in flooded conduits define the rhythmite lamination. The presence of allochthonous minerals indicates that the rhythmite sediment comes from the glacial erosion of nearby carbonate mountains. Two 234U/230Th radiometric ages dated the rhythmite deposits around 109 and 95 ka, coinciding with relative cold periods included in the MIS 5d-c. These cold periods were marked by a high annual seasonality, immediately after the glacial local maximum extension, in agreement with a varve-type deposit. The combination of these sedimentological mineralogical, geomorphological and paleoclimate information indicates that the rhythmite should be introduced into the studied cave during the summer melting of the glaciers, which produced the recharge of the karst aquifer, triggering cave floods. In addition, punctual glacier collapses would also have their imprint in the slackwater sequences with thicker, coarser and erosive sand deposits and the spring blocking by glaciers may have promoted floods inside the cave. Therefore, the studied rhythmite can be interpreted as glacial varves decanted during the relatively cold climate conditions.

Space Station Furnace Facility Management Information System (SSFF-MIS) Development

NASA Technical Reports Server (NTRS)

Meade, Robert M.

1996-01-01

This report summarizes the chronology, results, and lessons learned from the development of the SSFF-MIS. This system has been nearly two years in development and has yielded some valuable insights into specialized MIS development. General: In December of 1994, the Camber Corporation and Science Applications International Corporation (SAIC) were contracted to design, develop, and implement a MIS for Marshall Space Flight Center's Space Station Furnace Facility Project. The system was to be accessible from both EBM-Compatible PC and Macintosh platforms. The system was required to contain data manually entered into the MIS as well as data imported from other MSFC sources. Electronic interfaces were established for each data source and retrieval was to be performed at prescribed time intervals. The SOW requirement that predominantly drove the development software selection was the dual-platform (IBM-PC and Macintosh) requirement. The requirement that the system would be maintained by Government personnel influenced the selection of Commercial Off-the-shelf software because of its inherent stability and readily available documentation and support. Microsoft FoxPro Professional 2.6 for Windows and Macintosh was selected as the development tool. This is a software development tool that has been in use for many years. It is stable and powerful. Microsoft has since released the replacement for this product, Microsoft Visual FoxPro, but at the time of this development, it was only available on the Windows platform. The initial contract included included the requirement for capabilities relating to the Work- and Organizational Breakdown Structures, cost (plan and actuals), workforce (plan and actuals), critical path scheduling, trend analysis, procurements and contracts, interface to manufacturing, Safety and Mission Assurance, risk analysis, and technical performance indicators. It also required full documentation of the system and training of users. During the course of

The monsoon imprint during the `atypical' MIS 13 as seen through north and equatorial Indian Ocean records

NASA Astrophysics Data System (ADS)

Caley, Thibaut; Malaizé, Bruno; Bassinot, Franck; Clemens, Steven C.; Caillon, Nicolas; Linda, Rossignol; Charlier, Karine; Rebaubier, Helene

2011-09-01

Previous studies have suggested that Marine Isotope Stage (MIS) 13, recognized as atypical in many paleoclimate records, is marked by the development of anomalously strong summer monsoons in the northern tropical areas. To test this hypothesis, we performed a multi-proxy study on three marine records from the tropical Indian Ocean in order to reconstruct and analyse changes in the summer Indian monsoon winds and precipitations during MIS 13. Our data confirm the existence of a low-salinity event during MIS 13 in the equatorial Indian Ocean but we argue that this event should not be considered as "atypical". Taking only into account a smaller precession does not make it possible to explain such precipitation episode. However, when considering also the larger obliquity in a more complete orbitally driven monsoon "model," one can successfully explain this event. In addition, our data suggest that intense summer monsoon winds, although not atypical in strength, prevailed during MIS 13 in the western Arabian Sea. These strong monsoon winds, transporting important moisture, together with the effect of insolation and Eurasian ice sheet, are likely one of the factors responsible for the intense monsoon precipitation signal recorded in China loess, as suggested by model simulations.

The comprehensive study and the reduction of contact resistivity on the n-InGaAs M-I-S contact system with different inserted insulators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liao, M.-H., E-mail: mhliaoa@ntu.edu.tw; Lien, C.

2015-05-15

Five different kinds of insulators including BaTiO{sub 3}, TiO{sub 2}, Al{sub 2}O{sub 3}, CdO and ZnO on the n-type InGaAs metal-insulator-semiconductor (M-I-S) ohmic contact structure are studied. The effect for the dielectric constant (ε) of inserted insulator and the conduction band offset (CBO) between an insulator and semiconductor substrate is analyzed by a unified M-I-S contact model. Based on the theoretical model and experimental data, we demonstrates that the inserted ZnO insulator with the high electron affinity and the low CBO (∼0.1 eV) to the InGaAs substrate results in ∼10 times contact resistivity reduction, even the ε of ZnO ismore » not pretty high (∼10)« less

Early and Middle Pleistocene vegetation history of the Médoc region, southwest France

NASA Astrophysics Data System (ADS)

O'Brien, C. E.; Jones, R. L.

2003-09-01

Pleistocene deposits, together with their pollen, plant macrofossil, foraminiferal, dinoflagellate and coleopteran remains, from five sites along the Atlantic coast of the Médoc Peninsula are described and discussed. Sediments making up the Négade Formation are shown to have been laid down under either estuarine or lagoonal conditions when closed Quercus-Pinus-Tsuga canadensis regional woodland existed. Comparison with plant records from The Netherlands indicates that these deposits are most likely attributable to either the Early Pleistocene Bavel Interglacial (marine oxygen isotope stage (MIS) 31), or an interglacial of the Waalian (MIS 37-49) or Tiglian (MIS 63-79). In addition, clays assigned to the Argiles du Gurp sensu stricto, were similarly deposited in either an estuary or lagoon, which subsequently was cut off from the sea. A freshwater lake with vegetation dominated by Azolla filiculoides then developed. This was succeeded by reedswamp and an organic mud (termed Lignite in the corresponding French stratigraphical records) formed. Regional Quercus-Abies woodland was replaced by one with Pinus dominant and Pterocarya a minor component. Comparison with plant records from France and other parts of Europe suggest that the clays and organic mud might be correlated with the Holsteinian (Praclaux) Interglacial (MIS 11c). Copyright

Unexpected weak seasonal climate in the western Mediterranean region during MIS 31, a high-insolation forced interglacial

NASA Astrophysics Data System (ADS)

Oliveira, Dulce; Sánchez Goñi, Maria Fernanda; Naughton, Filipa; Polanco-Martínez, J. M.; Jimenez-Espejo, Francisco J.; Grimalt, Joan O.; Martrat, Belen; Voelker, Antje H. L.; Trigo, Ricardo; Hodell, David; Abrantes, Fátima; Desprat, Stéphanie

2017-04-01

Marine Isotope Stage 31 (MIS 31) is an important analogue for ongoing and projected global warming, yet key questions remain about the regional signature of its extreme orbital forcing and intra-interglacial variability. Based on a new direct land-sea comparison in SW Iberian margin IODP Site U1385 we examine the climatic variability between 1100 and 1050 ka including the ;super interglacial; MIS 31, a period dominated by the 41-ky obliquity periodicity. Pollen and biomarker analyses at centennial-scale-resolution provide new insights into the regional vegetation, precipitation regime and atmospheric and oceanic temperature variability on orbital and suborbital timescales. Our study reveals that atmospheric and SST warmth during MIS 31 was not exceptional in this region highly sensitive to precession. Unexpectedly, this warm stage stands out as a prolonged interval of a temperate and humid climate regime with reduced seasonality, despite the high insolation (precession minima values) forcing. We find that the dominant forcing on the long-term temperate forest development was obliquity, which may have induced a decrease in summer dryness and associated reduction in seasonal precipitation contrast. Moreover, this study provides the first evidence for persistent atmospheric millennial-scale variability during this interval with multiple forest decline events reflecting repeated cooling and drying episodes in SW Iberia. Our direct land-sea comparison shows that the expression of the suborbital cooling events on SW Iberian ecosystems is modulated by the predominance of high or low-latitude forcing depending on the glacial/interglacial baseline climate states. Severe dryness and air-sea cooling is detected under the larger ice volume during glacial MIS 32 and MIS 30. The extreme episodes, which in their climatic imprint are similar to the Heinrich events, are likely related to northern latitude ice-sheet instability and a disruption of the Atlantic Meridional Overturning

The Last Interglacial in the Levant: Perspective from the ICDP Dead Sea Deep Drill Core

NASA Astrophysics Data System (ADS)

Goldstein, S. L.; Torfstein, A.; Stein, M.; Kushnir, Y.; Enzel, Y.; Haug, G. H.

2014-12-01

Sediments recovered by the ICDP Dead Sea Deep Drilling Project provide a new perspective on the climate history of the Levant during the last interglacial period MIS5. They record the extreme impacts of an intense interglacial characterized by stronger insolation, warmer mean global temperatures, and higher sea-levels than the Holocene. Results show both extreme hyper-aridity during MIS5e, including an unprecedented drawdown of Dead Sea water levels, and the impacts of a strong precession-driven African monsoon responsible for a major sapropel event (S5) in the eastern Mediterranean. Hyper-arid conditions at the beginning of MIS5e prior to S5 (~132-128 ka) are evidenced by halite deposition, indicating declining Dead Sea lake levels. Surprisingly, the hyper-arid phase is interrupted during the MIS5e peak (~128-120 ka), coinciding with the S5 sapropel, which is characterized by a thick (23 m) section of silty detritus (without any halite) whose provenance indicates southern-sourced wetness in the watershed. Upon weakening of the S5 monsoon (~120-115 ka), the return of extreme aridity resulted in an unprecedented lake level drawdown, reflected by massive salt deposition, and followed by a sediment hiatus (~115-100 ka) indicating prolonged low lake level. The resumption of section follows classic Levant patterns with more wetness during cooler MIS5b and hyper-aridity during warmer MIS5a. The ICDP core provides the first evidence for a direct linkage between an intense precession-driven African monsoon and wetness at the high subtropical latitude (~30N) of the Dead Sea watershed. Combined with coeval deposition of Negev speleothems and travertines, and calcitification of Red Sea corals, the evidence indicates a wet climatic corridor that could facilitate homo sapiens migration out of Africa during the MIS5e peak. In addition, the MIS 5e hyper-arid intervals may provide an important cautionary analogue for the impact of future warming on regional water resources.

CDKL5 and ARX mutations in males with early-onset epilepsy.

PubMed

Mirzaa, Ghayda M; Paciorkowski, Alex R; Marsh, Eric D; Berry-Kravis, Elizabeth M; Medne, Livija; Alkhateeb, Asem; Grix, Art; Wirrell, Elaine C; Powell, Berkley R; Nickels, Katherine C; Burton, Barbara; Paras, Andrea; Kim, Katherine; Chung, Wendy; Dobyns, William B; Das, Soma

2013-05-01

Mutations in CDKL5 and ARX are known causes of early-onset epilepsy and severe developmental delay in males and females. Although numerous males with ARX mutations associated with various phenotypes have been reported in the literature, the majority of CDKL5 mutations have been identified in females with a phenotype characterized by early-onset epilepsy, severe global developmental delay, absent speech, and stereotypic hand movements. To date, only 10 males with CDKL5 mutations have been reported. Our retrospective study reports on the clinical, neuroimaging, and molecular findings of 18 males with early-onset epilepsy caused by either CDKL5 or ARX mutations. These 18 patients include eight new males with CDKL5 mutations and 10 with ARX mutations identified through sequence analysis of 266 and 346 males, respectively, at our molecular diagnostic laboratory. Our large dataset therefore expands on the number of reported males with CDKL5 mutations and highlights that aberrations of CDKL5 and ARX combined are an important consideration in the genetic forms of early-onset epilepsy in boys. Copyright © 2013 Elsevier Inc. All rights reserved.

CDKL5 and ARX mutations in males with early-onset epilepsy

PubMed Central

Mirzaa, Ghayda M.; Paciorkowski, Alex R.; Marsh, Eric D.; Berry-Kravis, Elizabeth M.; Medne, Livija; Grix, Art; Wirrell, Elaine C.; Powell, Berkley R.; Nickels, Katherine C.; Burton, Barbara; Paras, Andrea; Kim, Katherine; Chung, Wendy; Dobyns, William B.; Das, Soma

2013-01-01

Mutations in CDKL5 and ARX are known causes of early-onset epilepsy and severe developmental delay in males and females. While numerous males with ARX mutations associated with various phenotypes have been reported in the literature, the majority of CDKL5 mutations have been identified in females with a phenotype characterized by early-onset epilepsy, severe global developmental delay, absent speech, and stereotypic hand movements. To date, only ten males with CDKL5 mutations have been reported. Our retrospective study reports on the clinical, neuroimaging and molecular findings of 18 males with early-onset epilepsy caused by either CDKL5 or ARX mutations. The 18 patients include eight new males with CDKL5 mutations and ten with ARX mutations identified through sequence analysis of 266 and 346 males, respectively, at our molecular diagnostic laboratory. Our large data set therefore expands on the number of reported males with CDKL5 mutations and highlights that aberrations of CDKL5 and ARX combined are an important consideration in the genetic forms of early-onset epilepsy. PMID:23583054

Late Quaternary Variability of Arctic Sea Ice: Insights From Biomarker Proxy Records and Model Simulations

NASA Astrophysics Data System (ADS)

Stein, R. H.; Fahl, K.; Gierz, P.; Niessen, F.; Lohmann, G.

2017-12-01

Over the last about four decades, coinciding with global warming and atmospheric CO2increase, the extent and thickness of Arctic sea ice has decreased dramatically, a decrease much more rapid than predicted by climate models. The driving forces of this change are still not fully understood. In this context, detailed paleoclimatic records going back beyond the timescale of direct observations, i.e., high-resolution Holocene records but also records representing more distant warm periods, may help to to distinguish and quantify more precisely the natural and anthropogenic greenhouse gas forcing of global climate change and related sea ice decrease. Here, we concentrate on sea ice biomarker records representing the penultimate glacial/last interglacial (MIS 6/MIS 5e) and the Holocene time intervals. Our proxy records are compared with climate model simulations using a coupled atmosphere-ocean general circulation model (AOGCM). Based on our data, polynya-type sea ice conditions probably occurred off the major ice sheets along the northern Barents and East Siberian continental margins during late MIS 6. Furthermore, we demonstrate that even during MIS 5e, i.e., a time interval when the high latitudes have been significantly warmer than today, sea ice existed in the central Arctic Ocean during summer, whereas sea ice was significantly reduced along the Barents Sea continental margin influenced by Atlantic Water inflow. Assuming a closed Bering Strait (no Pacific Water inflow) during early MIS 5, model simulations point to a significantly reduced sea ice cover in the central Arctic Ocean, a scenario that is however not supported by the proxy record and thus seems to be less realistic. Our Holocene biomarker proxy records from the Chukchi Sea indicate that main factors controlling the millennial Holocene variability in sea ice are probably changes in surface water and heat flow from the Pacific into the Arctic Ocean as well as the long-term decrease in summer insolation

First clinical results of minimally invasive vector lumbar interbody fusion (MIS-VLIF) in spondylodiscitis and concomitant osteoporosis: a technical note.

PubMed

Rieger, Bernhard; Jiang, Hongzhen; Ruess, Daniel; Reinshagen, Clemens; Molcanyi, Marek; Zivcak, Jozef; Tong, Huaiyu; Schackert, Gabriele

2017-12-01

First description of MIS-VLIF, a minimally invasive lumbar stabilization, to evaluate its safety and feasibility in patients suffering from weak bony conditions (lumbar spondylodiscitis and/or osteoporosis). After informed consent, 12 patients suffering from lumbar spondylodiscitis underwent single level MIS-VLIF. Eight of them had a manifest osteoporosis, either. Pre- and postoperative clinical status was documented using numeric rating scale (NRS) for leg and back pain. In all cases, the optimal height for the cage was preoperatively determined using software-based range of motion and sagittal balance analysis. CT scans were obtained to evaluate correct placement of the construct and to verify fusion after 6 months. Since 2013, 12 patients with lumbar pyogenic spondylodiscitis underwent MIS-VLIF. Mean surgery time was 169 ± 28 min and average blood loss was less than 400 ml. Postoperative CT scans showed correct placement of the implants. Eleven patients showed considerable postoperative improvement in clinical scores. In one patient, we observed screw loosening. After documented bony fusion in the CT scan, the fixation system was removed in two cases to achieve lower material load. The load-bearing trajectories (vectors) of MIS-VLIF are different from those of conventional coaxial pedicle screw implantation. The dorsally converging construct combines the heads of the dorsoventral pedicle screws with laminar pedicle screws following cortical bone structures within a small approach. In case of lumbar spondylodiscitis and/or osteoporosis, MIS-VLIF relies on cortical bony structures for all screw vectors and the construct does not depend on conventional coaxial pedicle screws in the presence of inflamed, weak, cancellous or osteoporotic bone. MIS-VLIF allows full 360° lumbar fusion including cage implantation via a small, unilateral dorsal midline approach.

Admittance Investigation of MIS Structures with HgTe-Based Single Quantum Wells.

PubMed

Izhnin, Ihor I; Nesmelov, Sergey N; Dzyadukh, Stanislav M; Voitsekhovskii, Alexander V; Gorn, Dmitry I; Dvoretsky, Sergey A; Mikhailov, Nikolaj N

2016-12-01

This work presents results of the investigation of admittance of metal-insulator-semiconductor structure based on Hg1 - x Cd x Te grown by molecular beam epitaxy. The structure contains a single quantum well Hg0.35Cd0.65Te/HgTe/Hg0.35Cd0.65Te with thickness of 5.6 nm in the sub-surface layer of the semiconductor. Both the conductance-voltage and capacitance-voltage characteristics show strong oscillations when the metal-insulator-semiconductor (MIS) structure with a single quantum well based on HgTe is biased into the strong inversion mode. Also, oscillations on the voltage dependencies of differential resistance of the space charge region were observed. These oscillations were related to the recharging of quantum levels in HgTe.

Capacitance-voltage characterization of Al/Al2O3/PVA-PbSe MIS diode

NASA Astrophysics Data System (ADS)

Gawri, Isha; Sharma, Mamta; Jindal, Silky; Singh, Harpreet; Tripathi, S. K.

2018-05-01

The present paper reports the capacitance-voltage characterization of Al/Al2O3/PVA-PbSe MIS diode using chemical bath deposition method. Here anodic alumina layer prepared using electrolytic deposition method on Al substrate is used as insulating material. Using the capacitance-voltage variation at a fixed frequency, the different parameters such as Depletion layer width, Barrier height, Built-in voltage and Carrier concentration has been calculated at room temperature as well as at temperature range from 123 K to 323 K. With the increase in temperature the barrier height and depletion layer width follow a decreasing trend. Therefore, the capacitance-voltage characterization at different temperatures characterization provides strong evidence that the properties of MIS diode are primarily affected by diode parameters.

From Lake Malawi Drilling: East African Climate May Have Caused Major Evolutionary Turnover in Mammalian Species During MIS 14

NASA Astrophysics Data System (ADS)

Johnson, Thomas; Werne, Josef

2016-04-01

Hominin evolution underwent important changes in the last 1.3 million years, including the extinction of Paranthropus at about 1.2 Ma, leaving Homo as the sole hominin genus. Our genus experienced a major increase in cranial capacity at about 500 ka, and our species, H. sapiens, first appeared at ~200 ka. There was a major turnover in mammalian species in East Africa between 540 and 400 ka, favoring descendants of smaller size and less specialized diet. An understanding of what drove evolution in these directions is fundamental to understanding the development of modern H. sapiens. Climate certainly played a role, for it is the principal factor that influences the distribution of vegetation and habitability on the landscape. We present a 1.3 million year record of temperature and hydroclimate in the basin of Lake Malawi, the second deepest lake in Africa, derived from a 380 m sediment sequence taken from a water depth of 590 m by the Lake Malawi Drilling Project. Seismic reflection profiles used to select the site portray an undisturbed sedimentary section that was not impacted by erosion, turbidity currents or mass wasting events. Sediment samples were analyzed to produce records of temperature (TEX86) and aridity (Ca content and leaf wax δ13C). The temperature record displays progressively larger amplitude glacial-interglacial variations from MIS 13 (~500 ka) to MIS 5 (~125 ka). Intervals of low Ca abundance, which reflect lake high stands, correlate with times of depleted δ13Cwax and relatively warm temperatures. The Malawi basin experienced warm, wet interglacials and cooler (by about 2 - 4°C), dry glacial periods, with roughly a 100 ky periodicity since the Mid-Pleistocene Transition (MPT), about 900 ka. The paleoclimate record from Lake Malawi sediments portrays a transition from a highly variable and predominantly arid climate prior to 900 ka to a progressively more humid environment after the MPT dominated by 100 ky cycles consisting of warm, wet

Radiographic and clinical outcomes following MIS-TLIF in patients with adult lumbar degenerative scoliosis.

PubMed

Zhao, Yongfei; Liang, Yan; Mao, Keya

2018-04-19

Patients suffering from adult lumbar degenerative scoliosis (ALDS) are commonly complicated with advanced age, osteoporosis, cardiopulmonary insufficiency, and some other medical comorbidity. Therefore, the traditional open surgery can lead to high rate of postoperative complications. The purposes of this study were to introduce our experiences and explore the efficacy and feasibility of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in the treatment of patients with ALDS. From January 2008 to January 2014, a retrospective study of 22 patients with ALDS treated with MIS-TLIF was followed up at least 2 years. All patients suffered from one-level lumbar stenosis, and the nerve root block was performed to make sure the exact level. The clinical and radiographic outcomes were evaluated preoperatively and at the time of 2-year follow-up. The mean visual analog scale (VAS) back pain scores decreased from 6.2 ± 1.8 preoperatively to 2.2 ± 0.7 at 2-year follow-up (P < 0.05), and the mean VAS leg pain scores decreased from 8.2 ± 0.7 preoperatively to 1.4 ± 1.4 at 2-year follow-up (P < 0.05). The Oswestry Disability Index score improved from 62.4 ± 16.1% preoperatively to 24.2 ± 9.3% at 2-year follow-up (P < 0.05). The average lumbar curve was 20.7° ± 7.0° preoperatively and 12.7° ± 7.1° at 2-year follow-up (P < 0.05). The lumbar lordosis changed from - 39.5° ± 13.6° to - 43.6° ± 10.6° at 2-year follow-up (P < 0.05). Solid fusion was achieved in all patients. The technique of MIS-TLIF can be used to treat the patients with ALDS whose symptom is mainly from one-level lumbar stenosis, achieving favorable clinical outcomes and good fusion, with less blood loss and complications.

Extensive MIS 3 glaciation in southernmost Patagonia revealed by cosmogenic nuclide dating of outwash sediments

NASA Astrophysics Data System (ADS)

Darvill, Christopher M.; Bentley, Michael J.; Stokes, Chris R.; Hein, Andrew S.; Rodés, Ángel

2015-11-01

The timing and extent of former glacial advances can demonstrate leads and lags during periods of climatic change and their forcing, but this requires robust glacial chronologies. In parts of southernmost Patagonia, dating pre-global Last Glacial Maximum (gLGM) ice limits has proven difficult due to post-deposition processes affecting the build-up of cosmogenic nuclides in moraine boulders. Here we provide ages for the Río Cullen and San Sebastián glacial limits of the former Bahía Inútil-San Sebastián (BI-SSb) ice lobe on Tierra del Fuego (53-54°S), previously hypothesised to represent advances during Marine Isotope Stages (MIS) 12 and 10, respectively. Our approach uses cosmogenic 10Be and 26Al exposure dating, but targets glacial outwash associated with these limits and uses depth-profiles and surface cobble samples, thereby accounting for surface deflation and inheritance. The data reveal that the limits formed more recently than previously thought, giving ages of 45.6 ka (+139.9/-14.3) for the Río Cullen, and 30.1 ka (+45.6/-23.1) for the San Sebastián limits. These dates indicate extensive glaciation in southern Patagonia during MIS 3, prior to the well-constrained, but much less extensive MIS 2 (gLGM) limit. This suggests the pattern of ice advances in the region was different to northern Patagonia, with the terrestrial limits relating to the last glacial cycle, rather than progressively less extensive glaciations over hundreds of thousands of years. However, the dates are consistent with MIS 3 glaciation elsewhere in the southern mid-latitudes, and the combination of cooler summers and warmer winters with increased precipitation, may have caused extensive glaciation prior to the gLGM.

Paleoclimatic and paleoceanographic records through Marine Isotope Stage 19 at the Chiba composite section, central Japan: A key reference for the Early-Middle Pleistocene Subseries boundary

NASA Astrophysics Data System (ADS)

Suganuma, Yusuke; Haneda, Yuki; Kameo, Koji; Kubota, Yoshimi; Hayashi, Hiroki; Itaki, Takuya; Okuda, Masaaki; Head, Martin, J.; Sugaya, Manami; Nakazato, Hiroomi; Igarashi, Atsuo; Shikoku, Kizuku; Hongo, Misao; Watanabe, Masami; Satoguchi, Yasufumi; Takeshita, Yoshihiro; Nishida, Naohisa; Izumi, Kentaro; Kawamura, Kenji; Kawamata, Moto; Okuno, Jun'ichi; Yoshida, Takeshi; Ogitsu, Itaru; Yabusaki, Hisashi; Okada, Makoto

2018-07-01

Marine Isotope Stage (MIS) 19 is an important analogue for the present interglacial because of its similar orbital configuration, especially the phasing of the obliquity maximum to precession minimum. However, sedimentary records suitable for capturing both terrestrial and marine environmental changes are limited, and thus the climatic forcing mechanisms for MIS 19 are still largely unknown. The Chiba composite section, east-central Japanese archipelago, is a continuous and expanded marine sedimentary succession well suited to capture terrestrial and marine environmental changes through MIS 19. In this study, a detailed oxygen isotope chronology is established from late MIS 20 to early MIS 18, supported by a U-Pb zircon age and the presence of the Matuyama-Brunhes boundary. New pollen, marine microfossil, and planktonic foraminiferal δ18O and Mg/Ca paleotemperature records reveal the complex interplay of climatic influences. Our pollen data suggest that the duration of full interglacial conditions during MIS 19 extends from 785.0 to 775.1 ka (9.9 kyr), which offers an important natural baseline in predicting the duration of the present interglacial. A Younger Dryas-type cooling event is present during Termination IX, suggesting that such events are linked to this orbital configuration. Millennial- to multi-millennial-scale variations in our δ18O and Mg/Ca records imply that the Subarctic Front fluctuated in the northwestern Pacific Ocean during late MIS 19, probably in response to East Asian winter monsoon variability. The climatic setting at this time appears to be related to less severe summer insolation minima at 65˚N and/or high winter insolation at 50˚N. Our records do not support a recently hypothesized direct coupling between variations in the geomagnetic field intensity and global/regional climate change. Our highly resolved paleoclimatic and paleoceanographic records, coupled with a well-defined Matuyama-Brunhes boundary (772.9 ka; duration 1.9 kyr

Oceanic response to changes in the WAIS and astronomical forcing during the MIS31 superinterglacial

NASA Astrophysics Data System (ADS)

Justino, Flavio; Lindemann, Douglas; Kucharski, Fred; Wilson, Aaron; Bromwich, David; Stordal, Frode

2017-09-01

Marine Isotope Stage 31 (MIS31, between 1085 and 1055 ka) was characterized by higher extratropical air temperatures and a substantial recession of polar glaciers compared to today. Paleoreconstructions and model simulations have increased the understanding of the MIS31 interval, but questions remain regarding the role of the Atlantic and Pacific oceans in modifying the climate associated with the variations in Earth's orbital parameters. Multi-century coupled climate simulations, with the astronomical configuration of the MIS31 and modified West Antarctic Ice Sheet (WAIS) topography, show an increase in the thermohaline flux and northward oceanic heat transport (OHT) in the Pacific Ocean. These oceanic changes are driven by anomalous atmospheric circulation and increased surface salinity in concert with a stronger meridional overturning circulation (MOC). The intensified northward OHT is responsible for up to 85 % of the global OHT anomalies and contributes to the overall reduction in sea ice in the Northern Hemisphere (NH) due to Earth's astronomical configuration. The relative contributions of the Atlantic Ocean to global OHT and MOC anomalies are minor compared to those of the Pacific. However, sea ice changes are remarkable, highlighted by decreased (increased) cover in the Ross (Weddell) Sea but widespread reductions in sea ice across the NH.

Fabrication of Ta2O5/GeNx gate insulator stack for Ge metal-insulator-semiconductor structures by electron-cyclotron-resonance plasma nitridation and sputtering deposition techniques

NASA Astrophysics Data System (ADS)

Otani, Yohei; Itayama, Yasuhiro; Tanaka, Takuo; Fukuda, Yukio; Toyota, Hiroshi; Ono, Toshiro; Mitsui, Minoru; Nakagawa, Kiyokazu

2007-04-01

The authors have fabricated germanium (Ge) metal-insulator-semiconductor (MIS) structures with a 7-nm-thick tantalum pentaoxide (Ta2O5)/2-nm-thick germanium nitride (GeNx) gate insulator stack by electron-cyclotron-resonance plasma nitridation and sputtering deposition. They found that pure GeNx ultrathin layers can be formed by the direct plasma nitridation of the Ge surface without substrate heating. X-ray photoelectron spectroscopy revealed no oxidation of the GeNx layer after the Ta2O5 sputtering deposition. The fabricated MIS capacitor with a capacitance equivalent thickness of 4.3nm showed excellent leakage current characteristics. The interface trap density obtained by the modified conductance method was 4×1011cm-2eV-1 at the midgap.

Admittance of MIS-Structures Based on HgCdTe with a Double-Layer CdTe/Al2O3 Insulator

NASA Astrophysics Data System (ADS)

Dzyadukh, S. M.; Voitsekhovskii, A. V.; Nesmelov, S. N.; Sidorov, G. Yu.; Varavin, V. S.; Vasil'ev, V. V.; Dvoretsky, S. A.; Mikhailov, N. N.; Yakushev, M. V.

2018-03-01

Admittance of MIS structures based on n( p)- Hg1-xCdxTe (at x from 0.22 to 0.40) with SiO2/Si3N4, Al2O3, and CdTe/Al2O3 insulators is studied experimentally at 77 K. Growth of an intermediate CdTe layer during epitaxy results in the almost complete disappearance of the hysteresis of electrophysical characteristics of MIS structures based on graded-gap n-HgCdTe for a small range of the voltage variation. For a wide range of the voltage variation, the hysteresis of the capacitance-voltage characteristics appears for MIS structures based on n-HgCdTe with the CdTe/Al2O3 insulator. However, the hysteresis mechanism differs from that in case of a single-layer Al2O3 insulator. For MIS structures based on p-HgCdTe, introduction of an additional CdTe layer does not lead to a significant decrease of the hysteresis phenomena, which may be due to the degradation of the interface properties when mercury leaves the film as a result of low-temperature annealing changing the conductivity type of the semiconductor.

Effect on neurostimulation of injectates used for perineural space expansion before placement of a stimulating catheter: normal saline versus dextrose 5% in water.

PubMed

Pham Dang, Charles; Lelong, Aurélie; Guilley, Jérôme; Nguyen, Jean Michel; Volteau, Christelle; Venet, Guillaume; Perrier, Cyril; Lejus, Corinne; Blanloeil, Yvonnick

2009-01-01

We clinically assessed the electrophysiologic effect of dextrose 5% in water (D5W) and of normal saline (NS) used for expansion of the perineural space before placing a stimulating catheter. We questioned if higher current was required with NS but not with D5W, as has been observed experimentally. This was a prospective randomized double-blind study of ASA I to II patients scheduled for total knee replacement. Patients from 2 hospitals were randomly assigned to receive unidentified injectate D5W (n = 25) or NS (n = 25). The primary outcome was the minimal intensity of stimulation (MIS) recorded before and after 2 and 5 mL of study injectates were flushed through the needle before placing a stimulating catheter for continuous femoral and sciatic nerve blocks. Secondary outcomes included, among other parameters, MIS recorded during placement of stimulating catheters. No difference between groups was found with MIS before injection. However, MIS recorded during neurostimulation via the needle in all blocks was significantly higher after 2 and 5 mL of NS than after D5W. In femoral blocks, MIS recorded during placement of catheters was higher during insertion after NS than after D5W but was not different after reaching the final site, regardless of injectate used. In sciatic blocks, MIS was not different during insertion regardless of injectate but was higher after NS than after D5W after reaching the final site. The current needed to electrostimulate the femoral or sciatic nerve was higher after injection of NS than after D5W.

Investigating Analytic Tools for e-Book Design in Early Literacy Learning

ERIC Educational Resources Information Center

Roskos, Kathleen; Brueck, Jeremy; Widman, Sarah

2009-01-01

Toward the goal of better e-book design to support early literacy learning, this study investigates analytic tools for examining design qualities of e-books for young children. Three research-based analytic tools related to e-book design were applied to a mixed genre collection of 50 e-books from popular online sites. Tool performance varied…

[A feasibility research of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) using hybrid internal fixation for recurrent lumbar disc herniation].

PubMed

Mao, Ke-ya; Wang, Yan; Xiao, Song-hua; Zhang, Yong-gang; Liu, Bao-wei; Wang, Zheng; Zhang, Xi-Feng; Cui, Geng; Zhang, Xue-song; Li, Peng; Mao, Ke-zheng

2013-08-01

To investigate the feasibility of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) using hybrid internal fixation of pedicle screws and a translaminar facet screw for recurrent lumbar disc herniation. From January 2010 to December 2011, 16 recurrent lumbar disc herniation patients, 10 male and 6 female patients with an average age of 45 years (35-68 years) were treated with unilateral incision MIS-TLIF through working channel. After decompression, interbody fusion and fixation using unilateral pedicle screws, a translaminar facet screw was inserted from the same incision through spinous process and laminar to the other side facet joint. The results of perioperative parameters, radiographic images and clinical outcomes were assessed. The repeated measure analysis of variance was applied in the scores of visual analogue scale (VAS) and Oswestry disablity index (ODI). All patients MIS-TLIF were accomplished under working channel including decompression, interbody fusion and hybrid fixation without any neural complication. The average operative time was (148 ± 75) minutes, the average operative blood loss was (186 ± 226) ml, the average postoperative ambulation time was (32 ± 15) hours, and the average hospitalization time was (6 ± 4) days. The average length of incision was (29 ± 4) mm, and the average length of translaminar facets screw was (52 ± 6) mm. The mean follow-up was 16.5 months with a range of 12-24 months. The postoperative X-ray and CT images showed good position of the hybrid internal fixation, and all facets screws penetrate through facets joint. The significant improvement could be found in back pain VAS, leg pain VAS and ODI scores between preoperative 1 day and postoperative follow-up at all time-points (back pain VAS:F = 52.845, P = 0.000;leg pain VAS:F = 113.480, P = 0.000;ODI:F = 36.665, P = 0.000). Recurrent lumbar disc herniation could be treated with MIS-TLIF using hybrid fixation through unilateral incision, and the

USAID Expands eMODIS Coverage for Famine Early Warning

NASA Astrophysics Data System (ADS)

Jenkerson, C.; Meyer, D. J.; Evenson, K.; Merritt, M.

2011-12-01

Food security in countries at risk is monitored by U.S. Agency for International Development (USAID) through its Famine Early Warning Systems Network (FEWS NET) using many methods including Moderate Resolution Imaging Spectroradiometer (MODIS) data processed by U.S. Geological Survey (USGS) into eMODIS Normalized Difference Vegetation Index (NDVI) products. Near-real time production is used comparatively with trends derived from the eMODIS archive to operationally monitor vegetation anomalies indicating threatened cropland and rangeland conditions. eMODIS production over Central America and the Caribbean (CAMCAR) began in 2009, and processes 10-day NDVI composites every 5 days from surface reflectance inputs produced using predicted spacecraft and climatology information at Land and Atmosphere Near real time Capability for Earth Observing Systems (EOS) (LANCE). These expedited eMODIS composites are backed by a parallel archive of precision-based NDVI calculated from surface reflectance data ordered through Level 1 and Atmosphere Archive and Distribution System (LAADS). Success in the CAMCAR region led to the recent expansion of eMODIS production to include Africa in 2010, and Central Asia in 2011. Near-real time 250-meter products are available for each region on the last day of an acquisition interval (generally before midnight) from an anonymous file transfer protocol (FTP) distribution site (ftp://emodisftp.cr.usgs.gov/eMODIS). The FTP site concurrently hosts the regional historical collections (2000 to present) which are also searchable using the USGS Earth Explorer (http://edcsns17.cr.usgs.gov/NewEarthExplorer). As eMODIS coverage continues to grow, these geographically gridded, georeferenced tagged image file format (GeoTIFF) NDVI composites increase their utility as effective tools for operational monitoring of near-real time vegetation data against historical trends.

An Alumni Assessment of MIS Related Job Skill Importance and Skill Gaps

ERIC Educational Resources Information Center

Wilkerson, Jerod W.

2012-01-01

This paper presents the results of a job skill survey of Management Information Systems (MIS) alumni from a Northeastern U.S. university. The study assesses job skill importance and skill gaps associated with 104 technical and non-technical skill items. Survey items were grouped into 6 categories based on prior research. Skill importance and skill…

Reshould I Take More MIS Courses? Implications from Interviews with Business Recruiters

ERIC Educational Resources Information Center

He, Jun; Guo, Yi Maggie

2015-01-01

It is important for MIS educators to have a good understanding of what IT knowledge and skills are required in business. In this study, 103 open job positions in the Midwestern United States were investigated via semi-structured interviews with hiring companies. The interviews with key business recruiters suggest that IT knowledge and skills are…

Student Motivational Profiles in an Introductory MIS Course: An Exploratory Cluster Analysis

ERIC Educational Resources Information Center

Nelson, Klara

2014-01-01

This study profiles students in an introductory MIS course according to a variety of variables associated with choice of academic major. The data were collected through a survey administered to 12 sections of the course. A two-step cluster analysis was performed with gender as a categorical variable and students' perceptions of task value…

Fully solution processed Al-TiO2-Si (MIS) structured photo-detector

NASA Astrophysics Data System (ADS)

Mondal, Sandip; Kumar, Arvind

2018-05-01

We demonstrate the fabrication of a high performance photo detector by fully solution processed technique. The detector is fabricated with photo sensitive, low temperature (200˚C) and sol-gel processed titanium dioxide (TiO2) dielectric material on silicon substrate in the form of MIS structure with top aluminum gate. The optical detection experiment is performed on Al—TiO2—Si (MIS) device by measuring the capacitance—voltage (CV at 100 kHz) curve within the visible region of light (365 — 700 nm). The presence of light shift the flat band voltage (VFB) from 290 mV to 360 mV due to the generation of photo activated charge carriers by UV (365 nm) and white light, respectively. Moreover, the generation of the charge carrier increases drastically by the combination of UV and white, which resulting as a very large shift (600 mV) in the VFB. The entire experiment was performed in normal lab conditions with open air environment, without any clean room facility.

The complexity of millennial-scale variability in southwestern Europe during MIS 11

NASA Astrophysics Data System (ADS)

Oliveira, Dulce; Desprat, Stéphanie; Rodrigues, Teresa; Naughton, Filipa; Hodell, David; Trigo, Ricardo; Rufino, Marta; Lopes, Cristina; Abrantes, Fátima; Sánchez Goñi, Maria Fernanda

2016-11-01

Climatic variability of Marine Isotope Stage (MIS) 11 is examined using a new high-resolution direct land-sea comparison from the SW Iberian margin Site U1385. This study, based on pollen and biomarker analyses, documents regional vegetation, terrestrial climate and sea surface temperature (SST) variability. Suborbital climate variability is revealed by a series of forest decline events suggesting repeated cooling and drying episodes in SW Iberia throughout MIS 11. Only the most severe events on land are coeval with SST decreases, under larger ice volume conditions. Our study shows that the diverse expression (magnitude, character and duration) of the millennial-scale cooling events in SW Europe relies on atmospheric and oceanic processes whose predominant role likely depends on baseline climate states. Repeated atmospheric shifts recalling the positive North Atlantic Oscillation mode, inducing dryness in SW Iberia without systematical SST changes, would prevail during low ice volume conditions. In contrast, disruption of the Atlantic meridional overturning circulation (AMOC), related to iceberg discharges, colder SST and increased hydrological regime, would be responsible for the coldest and driest episodes of prolonged duration in SW Europe.

Quaternary fluvial history of the Delaware River, New Jersey and Pennsylvania, USA: The effects of glaciation, glacioisostasy, and eustasy on a proglacial river system

NASA Astrophysics Data System (ADS)

Stanford, Scott D.; Witte, Ron W.; Braun, Duane D.; Ridge, John C.

2016-07-01

Fluvial, glacial, and estuarine deposits in the Delaware Valley record the response of the Delaware River to glaciation, sea-level change, and glacioisostasy during the Quaternary. Incision following an early Pleistocene glaciation created the present valley, which is inset into a Pliocene strath and fluvial plain. Middle and upper Pleistocene and Holocene deposits were laid down in this inset valley. Estuarine terraces in the lower valley and bayshore at + 20 m (probably Marine Isotope Stage [MIS] 11), + 8 m (MIS 5e), and + 3 m (MIS 5a or c), and a fluvial deposit that correlates to offshore MIS 3 marine deposits at - 20 m are at elevations consistent with glacioisostatic models. Successive incisions during lowstands in the middle and late Pleistocene lengthened, deepened, and narrowed the channel in the lower valley and shifted the channel westward in Delaware Bay. During MIS 2 glaciation, from 25 to 18 ka, the Delaware was diverted to the Hudson Shelf Valley by glacioisostatic tilting. Most glacial sediment was trapped in fluvial-lacustrine valley fills north of the terminal moraine. Incision of the valley fill was accomplished during the early stage of rebound, between 17 and 12 ka. Drainage to the Delaware shelf was restored between 15 and 13 ka as the forebulge collapsed. During incision, multiple postglacial terraces formed where the valley was perpendicular to rebound contours and so was steepened and elevated northward; and a single terrace formed where the valley paralleled the contours, and there was no differential elevation or steepening. About 65% of the original volume of MIS 2 glacial sediment remains in the main valley, and most of the eroded volume is in the channel in the lower valley beneath Holocene estuarine fill. Little glacial sediment reached the Delaware or Hudson shelf. Overbank deposition on the lower postglacial terrace and modern floodplain spans the Holocene. The volume of Holocene sediment in the estuary and bay yields a basinwide

Lepton identification at particle flow oriented detector for the future e+e- Higgs factories

NASA Astrophysics Data System (ADS)

Yu, Dan; Ruan, Manqi; Boudry, Vincent; Videau, Henri

2017-09-01

The lepton identification is essential for the physics programs at high-energy frontier, especially for the precise measurement of the Higgs boson. For this purpose, a toolkit for multivariate data analysis (TMVA) based lepton identification (LICH) has been developed for detectors using high granularity calorimeters. Using the conceptual detector geometry for the Circular Electron-Positron Collider (CEPC) and single charged particle samples with energy larger than 2 GeV, LICH identifies electrons/muons with efficiencies higher than 99.5% and controls the mis-identification rate of hadron to muons/electrons to better than 1/0.5%. Reducing the calorimeter granularity by 1-2 orders of magnitude, the lepton identification performance is stable for particles with E > 2 GeV. Applied to fully simulated eeH/μ μ H events, the lepton identification performance is consistent with the single particle case: the efficiency of identifying all the high energy leptons in an event, is 95.5-98.5%.

The Top Ten Critical MIS Issues in the Department of Defense

DTIC Science & Technology

1991-03-01

II. LITERATURE REVIEW A. INTRODUCTION There are five studies of Management Information Systems (MIS) critical issues similar to this one that are...detailed in Management Information Systems Quarterly and other IS publications. These studies were conducted and published between 1980 and 1990. B. BALL... Information Systems (SMIS). In 1980, they mailed questionnaires to 1400 members asking them to use a six-point Likert-type scale to rank the importance of 18

Response of the North Atlantic surface and intermediate ocean structure to climate warming of MIS 11.

PubMed

Kandiano, Evgenia S; van der Meer, Marcel T J; Schouten, Stefan; Fahl, Kirsten; Sinninghe Damsté, Jaap S; Bauch, Henning A

2017-04-10

Investigating past interglacial climates not only help to understand how the climate system operates in general, it also forms a vital basis for climate predictions. We reconstructed vertical stratification changes in temperature and salinity in the North Atlantic for a period some 400 ka ago (MIS11), an interglacial time analogue of a future climate. As inferred from a unique set of biogeochemical, geochemical, and faunal data, the internal upper ocean stratification across MIS 11 shows distinct depth-dependent dynamical changes related to vertical as well as lateral shifts in the upper Atlantic meridional circulation system. Importantly, transient cold events are recognized near the end of the long phase of postglacial warming at surface, subsurface, mid, and deeper water layers. These data demonstrate that MIS 11 coolings over the North Atlantic were initially triggered by freshwater input at the surface and expansion of cold polar waters into the Subpolar Gyre. The cooling signal was then transmitted downwards into mid-water depths. Since the cold events occurred after the main deglacial phase we suggest that their cause might be related to continuous melting of the Greenland ice sheet, a mechanism that might also be relevant for the present and upcoming climate.

Expanding the 5E Model.

ERIC Educational Resources Information Center

Eisenkraft, Arthur

2003-01-01

Amends the current 5E learning cycle and instructional model to a 7E model. Changes ensure that instructors do not omit crucial elements for learning from their lessons while under the incorrect assumption that they are meeting the requirements of the learning cycle. The proposed 7E model includes: (1) engage; (2) explore; (3) explain; (4) elicit;…

Sedimentary evidence of landscape and climate history since the end of MIS 3 in the Krkonoše Mountains, Czech Republic

NASA Astrophysics Data System (ADS)

Engel, Zbyněk; Nývlt, Daniel; Křížek, Marek; Treml, Václav; Jankovská, Vlasta; Lisá, Lenka

2010-04-01

A sedimentary core recovered from the cirque basin of Labský důl valley (1039 m a.s.l.) in the Krkonoše Mountains reflects the environmental history for approximately the last 30,000 years. Analyses of magnetic susceptibility, carbon content, pollen assemblages and macrofossil data in a 15 m thick sediment sequence provide the first continuous record of Lateglacial and Holocene vegetation history in Sudetes region of the Czech Republic. The succession of sedimentary units in the lower part of the core suggests that the cirque was ice-free before the onset of the last glaciation at the beginning of marine isotope stage 2. Highly variable climate prevailed during this period with cold conditions culminating about 18 cal ka BP. Cold climates persisted until the Lateglacial period, evidenced by an identified warming and subsequent cooling event correlated with the Younger Dryas period. Sparse, treeless vegetation dominated in the catchment area at that time. The sequence of interrupted thinly laminated silts reflects the retreat and temporary readvance of a local glacier in the cirque during 12.5-10.8 cal ka BP. Subsequently, the alpine treeline ecotone gradually shifted above the cirque floor. Palaeoclimatic conditions in the early Holocene fluctuated strongly, whereas since 5.1 cal ka BP conditions have been more stable. Pollen-based climate reconstructions suggest significant cooling at around 9.8-9.3, 7.7-7.5 and 4.0-3.3 cal ka BP. Spruce forests have dominated the site since 5.0 cal ka BP when the vegetation became similar to the modern one. Two phases of increased sedimentation were identified within the Holocene culminating about 9.2-7.5 cal ka BP and 5.8-5.5 cal ka BP. Sediment yield was as high as 2.4 mm yr -1 during the period, reflecting environmental changes during the Atlantic/Sub-Boreal transition.

Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase

PubMed Central

Furuya, Kanji; Takahashi, Kohta; Yanagida, Mitsuhiro

1998-01-01

The loss of sister chromatid cohesion triggers anaphase spindle movement. The budding yeast Mcd1/Scc1 protein, called cohesin, is required for associating chromatids, and proteins homologous to it exist in a variety of eukaryotes. Mcd1/Scc1 is removed from chromosomes in anaphase and degrades in G1. We show that the fission yeast protein, Mis4, which is required for equal sister chromatid separation in anaphase is a different chromatid cohesion molecule that behaves independent of cohesin and is conserved from yeast to human. Its inactivation in G1 results in cell lethality in S phase and subsequent premature sister chromatid separation. Inactivation in G2 leads to cell death in subsequent metaphase–anaphase progression but missegregation occurs only in the next round of mitosis. Mis4 is not essential for condensation, nor does it degrade in G1. Rather, it associates with chromosomes in a punctate fashion throughout the cell cycle. mis4 mutants are hypersensitive to hydroxyurea (HU) and UV irradiation but retain the ability to restrain cell cycle progression when damaged or sustaining a block to replication. The mis4 mutation results in synthetic lethality with a DNA ligase mutant. Mis4 may form a stable link between chromatids in S phase that is split rather than removed in anaphase. PMID:9808627

The Use of Facebook in an Introductory MIS Course: Social Constructivist Learning Environment

ERIC Educational Resources Information Center

Ractham, Peter; Kaewkitipong, Laddawan; Firpo, Daniel

2012-01-01

The major objective of this article is to evaluate via a Design Science Research Methodology (DSRM) the implementation of a Social Constructivist learning framework for an introductory Management Information System (MIS) course. Facebook was used as a learning artifact to build and foster a learning environment, and a series of features and…

E-nose based rapid prediction of early mouldy grain using probabilistic neural networks

PubMed Central

Ying, Xiaoguo; Liu, Wei; Hui, Guohua; Fu, Jun

2015-01-01

In this paper, early mouldy grain rapid prediction method using probabilistic neural network (PNN) and electronic nose (e-nose) was studied. E-nose responses to rice, red bean, and oat samples with different qualities were measured and recorded. E-nose data was analyzed using principal component analysis (PCA), back propagation (BP) network, and PNN, respectively. Results indicated that PCA and BP network could not clearly discriminate grain samples with different mouldy status and showed poor predicting accuracy. PNN showed satisfying discriminating abilities to grain samples with an accuracy of 93.75%. E-nose combined with PNN is effective for early mouldy grain prediction. PMID:25714125

Abrupt sand-dune accumulation at the northeastern margin of the Tibetan Plateau challenges the wet MIS3a inferred from numerous lake-highstands

PubMed Central

Long, Hao; Fuchs, Markus; Yang, Linhai; Cheng, Hongyi

2016-01-01

Over the Tibetan Plateau and adjacent regions, numerous 14C-based lake records revealed a ubiquitous wet climatic period during 40–25 ka (late MIS 3), which is in contradiction with the global pattern of generally cold and dry climates. This paper focuses on OSL dating results of a large set of sand dunes and alluvial sediments (50 OSL ages) from the Qinwangchuan (QWC) Basin at the northeast edge of the Tibetan Plateau, with the aim to test the validity of the anomalous wet condition for the late MIS 3 interval, evidenced by numerous lake highstands. The abrupt sand dune accumulation as indication of increased aridity in the study area was OSL dated to ~40–13 ka. This dry climatic inference of the sand dune system from QWC apparently shows no wet MIS 3a event. Thus, the anomalous wet conditions revealed by high lake levels for the late MIS 3 phase may not be a universal phenomena across entire western China. PMID:27172907

Palaeoclimate characteristics in interior Siberia of MIS 6-2: first insights from the Batagay permafrost mega-thaw slump in the Yana Highlands

NASA Astrophysics Data System (ADS)

Ashastina, Kseniia; Schirrmeister, Lutz; Fuchs, Margret; Kienast, Frank

2017-07-01

Syngenetic permafrost deposits formed extensively on and around the arising Beringian subcontinent during the Late Pleistocene sea level lowstands. Syngenetic deposition implies that all material, both mineral and organic, freezes parallel to sedimentation and remains frozen until degradation of the permafrost. Permafrost is therefore a unique archive of Late Pleistocene palaeoclimate. Most studied permafrost outcrops are situated in the coastal lowlands of northeastern Siberia; inland sections are, however, scarcely available. Here, we describe the stratigraphical, cryolithological, and geochronological characteristics of a permafrost sequence near Batagay in the Siberian Yana Highlands, the interior of the Sakha Republic (Yakutia), Russia, with focus on the Late Pleistocene Yedoma ice complex (YIC). The recently formed Batagay mega-thaw slump exposes permafrost deposits to a depth of up to 80 m and gives insight into a climate record close to Verkhoyansk, which has the most severe continental climate in the Northern Hemisphere. Geochronological dating (optically stimulated luminescence, OSL, and 14C ages) and stratigraphic implications delivered a temporal frame from the Middle Pleistocene to the Holocene for our sedimentological interpretations and also revealed interruptions in the deposition. The sequence of lithological units indicates a succession of several distinct climate phases: a Middle Pleistocene ice complex indicates cold stage climate. Then, ice wedge growth stopped due to highly increased sedimentation rates and eventually a rise in temperature. Full interglacial climate conditions existed during accumulation of an organic-rich layer - plant macrofossils reflected open forest vegetation existing under dry conditions during Marine Isotope Stage (MIS) 5e. The Late Pleistocene YIC (MIS 4-MIS 2) suggests severe cold-stage climate conditions. No alas deposits, potentially indicating thermokarst processes, were detected at the site. A detailed comparison

Temperature-Dependent Electrical Properties and Carrier Transport Mechanisms of TMAH-Treated Ni/Au/Al2O3/GaN MIS Diode

NASA Astrophysics Data System (ADS)

Reddy, M. Siva Pratap; Puneetha, Peddathimula; Reddy, V. Rajagopal; Lee, Jung-Hee; Jeong, Seong-Hoon; Park, Chinho

2016-11-01

The temperature-dependent electrical properties and carrier transport mechanisms of tetramethylammonium hydroxide (TMAH)-treated Ni/Au/Al2O3/GaN metal-insulator-semiconductor (MIS) diodes have been investigated by current-voltage ( I- V) and capacitance-voltage ( C- V) measurements. The experimental results reveal that the barrier height ( I- V) increases whereas the ideality factor decreases with increasing temperature. The TMAH-treated Ni/Au/Al2O3/GaN MIS diode showed nonideal behaviors which indicate the presence of a nonuniform distribution of interface states ( N SS) and effect of series resistance ( R S). The obtained R S and N SS were found to decrease with increasing temperature. Furthermore, it was found that different transport mechanisms dominated in the TMAH-treated Ni/Au/Al2O3/GaN MIS diode. At 150 K to 250 K, Poole-Frenkel emission (PFE) was found to be responsible for the reverse leakage, while Schottky emission (SE) was the dominant mechanism at high electric fields in the temperature range from 300 K to 400 K. Feasible energy band diagrams and possible carrier transport mechanisms for the TMAH-treated Ni/Au/Al2O3/GaN MIS diode are discussed based on PFE and SE.

The ESA Mice in Space (MIS) habitat: effects of cage confinement on neuromusculoskeletal structure and function and stress/behavior using wild-type C57Bl/6JRj mice in a modular science reference model (MSRM) test on ground

NASA Astrophysics Data System (ADS)

Blottner, Dieter; Vico, Laurence; Jamon, D. Berckmansp L. Vicop Y. Liup R. Canceddap M.

Background: Environmental conditions likely affect physiology and behaviour of mice used for Life Sciences Research on Earth and in Space. Thus, mice habitats with sufficient statistical numbers should be developed for adequate life support and care and that should meet all nesces-sary ethical and scientific requirements needed to successfully perform animal experimentation in Space. Aim of study: We here analysed the effects of cage confinement on the weightbear-ing musculoskeletal system, behaviour and stress of wild-type mice (C57BL/6JRj, 30 g b.wt., total n = 24) housed for 25 days in a prototypical ground-based MSRM (modular science ref-erence module) in the frame of breadboard activities for a fully automated life support habitat called "Mice in Space" (MIS) at the Leuven University, Belgium. Results: Compared with control housing (individually ventilated cages, IVC-mice) the MIS mice revealed no significant changes in soleus muscle size and myofiber distribution (type I vs. II) and quality of bone (3-D microarchitecture and mineralisation of calvaria, spine and femur) determined by confocal and micro-computed tomography. Corticosterone metabolism measured non-invasively (faeces) monitored elevated adrenocortical activity at only start of the MIS cage confinement (day 1). Behavioural tests (i.e., grip strength, rotarod, L/D box, elevated plus-maze, open field, ag-gressiveness) performed subsequently revealed only minor changes in motor performance (MIS vs. controls). Conclusions: The MIS habitat will not, on its own, produce major effects that could confound interpretation of data induced by microgravity exposure on orbit as planned for future biosatellite programmes. Sponsors: ESA-ESTEC, Noordwijk, NL

Characterization of a SiC MIS Schottky diode as RBS particle detector

NASA Astrophysics Data System (ADS)

Kaufmann, I. R.; Pick, A. C.; Pereira, M. B.; Boudinov, H. I.

2018-02-01

A 4H-SiC Schottky diode was investigated as a particle detector for Rutherford Backscattering Spectroscopy (RBS) experiment. The device was fabricated on a commercial 4H-SiC epitaxial n-type layer grown onto a 4H-SiC n+ type substrate wafer doped with nitrogen. Hafnium oxide with thickness of 1 nm was deposited by Atomic Layer Deposition and 10 nm of Ni were deposited by sputtering to form the Ni/HfO2/4H-SiC MIS Schottky structure. Current-Voltage curves with variable temperature were measured to extract the real Schottky Barrier Height (0.32 V) and ideality factor values (1.15). Reverse current and Capacitance-Voltage measurements were performed on the 4H-SiC detector and compared to a commercial Si barrier detector acquired from ORTEC. RBS data for four alpha energies (1, 1.5, 2 and 2.5 MeV) were collected from an Au/Si sample using the fabricated SiC and the commercial Si detectors simultaneously. The energy resolution for the fabricated detector was estimated to be between 75 and 80 keV.

CDKL5 mutations in boys with severe encephalopathy and early-onset intractable epilepsy.

PubMed

Elia, M; Falco, M; Ferri, R; Spalletta, A; Bottitta, M; Calabrese, G; Carotenuto, M; Musumeci, S A; Lo Giudice, M; Fichera, M

2008-09-23

To search for CDKL5 gene mutations in boys presenting with severe early-onset encephalopathy and intractable epilepsy, a clinical picture very similar to that already described in girls with CDKL5 mutations. Eight boys (age range 3-16 years, mean age 8.5 years, SD 4.38) with severe or profound mental retardation and early-onset intractable seizures were selected for CDKL5 gene mutation screening by denaturing high-performance liquid chromatography analysis. We found three unrelated boys carrying three different missense mutations of the CDKL5 gene: c.872G>A (p.C291Y), c.863C>T (p.T288I), and c.533G>C (p.R178P). They presented early-onset, polymorphous, and drug-resistant seizures, mostly myoclonic and tonic or spasms. EEG showed epileptiform abnormalities which were multifocal during wakefulness, and pseudoperiodic bisynchronous during sleep. This study describes three boys carrying CDKL5 missense mutations and their detailed clinical and EEG data, and indicates that CDKL5 gene mutations may represent a cause of severe or profound mental retardation and early-onset intractable seizures, also in boys. Screening for CDKL5 mutations is strongly recommended in individuals with these clinical features.

Deepwater carbonate ion concentrations in the western tropical Pacific since 250 ka: Evidence for oceanic carbon storage and global climate influence

NASA Astrophysics Data System (ADS)

Qin, Bingbin; Li, Tiegang; Xiong, Zhifang; Algeo, Thomas J.; Chang, Fengming

2017-04-01

We present new "size-normalized weight" (SNW)-Δ[CO32-] core-top calibrations for three planktonic foraminiferal species and assess their reliability as a paleo-alkalinity proxy. SNWs of Globigerina sacculifer and Neogloboquadrina dutertrei can be used to reconstruct past deep Pacific [CO32-], whereas SNWs of Pulleniatina obliquiloculata are controlled by additional environmental factors. Based on this methodological advance, we reconstruct SNW-based deepwater [CO32-] for core WP7 from the western tropical Pacific since 250 ka. Secular variation in the SNW proxy documents little change in deep Pacific [CO32-] between the Last Glacial Maximum and the Holocene. Further back in time, deepwater [CO32-] shows long-term increases from marine isotope stage (MIS) 5e to MIS 3 and from early MIS 7 to late MIS 6, consistent with the "coral reef hypothesis" that the deep Pacific Ocean carbonate system responded to declining shelf carbonate production during these two intervals. During deglaciations, we have evidence of [CO32-] peaks coincident with Terminations 2 and 3, which suggests that a breakdown of oceanic vertical stratification drove a net transfer of CO2 from the ocean to the atmosphere, causing spikes in carbonate preservation (i.e., the "deglacial ventilation hypothesis"). During MIS 4, a transient decline in SNW-based [CO32-], along with other reported [CO32-] and/or dissolution records, implies that increased deep-ocean carbon storage resulted in a global carbonate dissolution event. These findings provide new insights into the role of the deep Pacific in the global carbon cycle during the late Quaternary.

Challenges of DHS and MIS to capture the entire pattern of malaria parasite risk and intervention effects in countries with different ecological zones: the case of Cameroon.

PubMed

Massoda Tonye, Salomon G; Kouambeng, Celestin; Wounang, Romain; Vounatsou, Penelope

2018-04-06

In 2011, the demographic and health survey (DHS) in Cameroon was combined with the multiple indicator cluster survey. Malaria parasitological data were collected, but the survey period did not overlap with the high malaria transmission season. A malaria indicator survey (MIS) was also conducted during the same year, within the malaria peak transmission season. This study compares estimates of the geographical distribution of malaria parasite risk and of the effects of interventions obtained from the DHS and MIS survey data. Bayesian geostatistical models were applied on DHS and MIS data to obtain georeferenced estimates of the malaria parasite prevalence and to assess the effects of interventions. Climatic predictors were retrieved from satellite sources. Geostatistical variable selection was used to identify the most important climatic predictors and indicators of malaria interventions. The overall observed malaria parasite risk among children was 33 and 30% in the DHS and MIS data, respectively. Both datasets identified the Normalized Difference Vegetation Index and the altitude as important predictors of the geographical distribution of the disease. However, MIS selected additional climatic factors as important disease predictors. The magnitude of the estimated malaria parasite risk at national level was similar in both surveys. Nevertheless, DHS estimates lower risk in the North and Coastal areas. MIS did not find any important intervention effects, although DHS revealed that the proportion of population with an insecticide-treated nets access in their household was statistically important. An important negative relationship between malaria parasitaemia and socioeconomic factors, such as the level of mother's education, place of residence and the household welfare were captured by both surveys. Timing of the malaria survey influences estimates of the geographical distribution of disease risk, especially in settings with seasonal transmission. In countries with

A Last Interglacial pollen-temperature reconstruction, central North Island, New Zealand

NASA Astrophysics Data System (ADS)

Newnham, Rewi; Alloway, Brent; McGlone, Matt; Juchnowicz, Hannah; Rees, Andrew; Wilmshurst, Janet

2017-08-01

We present new pollen-temperature reconstructions for the Last Interglacial from central North Island, New Zealand using partial least squares regression (PLS) and modern analogue technique applied with the New Zealand pre-deforestation calibration pollen dataset. The pollen-bearing organic sequence includes numerous millimetre- to decimetre- thick tephra mostly from the adjacent Tongariro Volcanic Centre and is overlain by tephric cover-beds including the c. 25.4 ka cal BP Kawakawa/Oruanui Tephra. Fine-resolution pollen and preliminary diatom analyses above and below prominent tephra layers showed that significant vegetation impact followed only the thickest ashfall event (22 cm thickness), with vegetation recovery taking several hundred years. Apart from this, changes in the longer-term pollen record are likely to be related to climate oscillations that resemble the classic five-fold subdivision of MIS 5. The warmest interval, ascribed to MIS 5e, was characterised by tall, temperate rainforest, and occurs at the base of the sequence, with mean annual temperatures reaching around 1.1 °C higher than present. Mean annual temperatures declined to ∼4 °C below present during MIS 5d and MIS 5b and were within 1-2 °C of present during MIS 5c. The PLS temperature reconstructions are corroborated by estimates derived independently from elevational changes to vegetation communities, corresponding to modern temperature controls, inferred from the Karioi pollen spectra. Temperatures reconstructed quantitatively by the modern analogue technique were up to 1.3 °C higher for MIS 5e, MIS 5d and MIS 5b, possibly reflecting weaker modern vegetation analogues for these intervals.

Undegassed Carbon Content from a Highly Depleted Segment of the Mid-Atlantic Ridge (1-5°S): Evidence from Melt Inclusions

NASA Astrophysics Data System (ADS)

Le Voyer, M.; Kelley, K. A.; Cottrell, E.; Hauri, E. H.

2014-12-01

As carbon solubility is low in basalts, MORB contain little dissolved CO2 (189±61 ppm, 1σ, n=600 [1]). A global negative correlation between CO2/Nb (proxy for amount of CO2 lost by degassing) and Ba/La (proxy for source enrichment) indicates that depleted MORB are less affected by degassing than enriched MORB: CO2/Nb ratios range from 0-100 for samples with Ba/La>4, while CO2/Nb range from 50 to 400 for samples with Ba/La<4 [1]. To assess the CO2 content of undegassed MORB, we analyzed the volatile content of 70 olivine-hosted, glassy melt inclusions (MIs) from four basalts dredged along MAR 1-5°S, a ridge segment that produces highly depleted MORB in terms of trace element enrichment and radiogenic isotopes [2, 3]. MIs contain CO2 contents (180-1420 ppm) that are higher than their respective matrix glasses (130-220 ppm, typical for vapor-saturated melts erupted at 3-5 km b.s.l.). One of the four dredges (EN061 5D-3Ag) contains MIs that do not exhibit shrinkage bubbles. For this sample only, we find a positive correlation between the CO2 content (240-770 ppm) and the Cl content (6-20 ppm) of the MIs that is not found in the matrix glasses (see Fig.). We infer that the correlation between CO2 and Cl, both highly incompatible in silicate minerals during fractional crystallization, is strong evidence for vapor-undersaturation, as any CO2 degassing would have erased the correlation. Together with MIs from the Siqueiros Fracture Zone [4] and from northern Iceland [5], the MIs from EN061 5D-3Ag may represent another occurrence of carbon-undersaturated MORB. Our results will be used to model the primary carbon content of MORB and of the depleted upper mantle. Note that the average Cl content of the matrix glasses (20±1 ppm) is higher than those of the MIs (12±3 ppm, see Fig.). This indicates either that the matrix glasses assimilated a small amount of seawater Cl, or that the MIs are all more depleted than the matrix glass. We will acquire major and trace element

Detection and correction of false segmental duplications caused by genome mis-assembly

PubMed Central

2010-01-01

Diploid genomes with divergent chromosomes present special problems for assembly software as two copies of especially polymorphic regions may be mistakenly constructed, creating the appearance of a recent segmental duplication. We developed a method for identifying such false duplications and applied it to four vertebrate genomes. For each genome, we corrected mis-assemblies, improved estimates of the amount of duplicated sequence, and recovered polymorphisms between the sequenced chromosomes. PMID:20219098

45. William E. Barrett, Photographer, August 1975. EARLY STEAM GENERATING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. William E. Barrett, Photographer, August 1975. EARLY STEAM GENERATING UNIT USED TO PRODUCE ELECTRICITY FOR MANUFACTURING OPERATIONS AND FOR THE TOWN OF RAINELLE. STEAM ENGINE IS A HAMILTON CORLISS. - Meadow River Lumber Company, Highway 60, Rainelle, Greenbrier County, WV

47 CFR 9.5 - E911 Service.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 1 2014-10-01 2014-10-01 false E911 Service. 9.5 Section 9.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INTERCONNECTED VOICE OVER INTERNET PROTOCOL SERVICES § 9.5 E911 Service. (a) Scope of Section. The following requirements are only applicable to providers of...

47 CFR 9.5 - E911 Service.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 1 2013-10-01 2013-10-01 false E911 Service. 9.5 Section 9.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INTERCONNECTED VOICE OVER INTERNET PROTOCOL SERVICES § 9.5 E911 Service. (a) Scope of Section. The following requirements are only applicable to providers of...

47 CFR 9.5 - E911 Service.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 1 2012-10-01 2012-10-01 false E911 Service. 9.5 Section 9.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INTERCONNECTED VOICE OVER INTERNET PROTOCOL SERVICES § 9.5 E911 Service. (a) Scope of Section. The following requirements are only applicable to providers of...

Uranium-series ages of corals, sea level history, and palaeozoogeography, Canary Islands, Spain: an exploratory study for two Quaternary interglacial periods

USGS Publications Warehouse

Muhs, Daniel R.; Meco, Joaquín; Simmons, Kathleen R.

2014-01-01

We present the first U-series ages of corals from emergent marine deposits on the Canary Islands. Deposits at + 20 m are 481 ± 39 ka, possibly correlative to marine isotope stage (or MIS) 11, while those at + 12 and + 8 m are 120.5 ± 0.8 ka and 130.2 ± 0.8 ka, respectively, correlative to MIS 5.5. The age, elevations, and uplift rates derived from MIS 5.5 deposits on the Canary Islands allow calculations of hypothetical palaeo-sea levels during the MIS 11 high sea stand. Estimates indicate that the MIS 11 high sea stand likely was at least + 9 m (relative to present sea level) and could have been as high as + 24 m. The most conservative estimates of palaeo-sea level during MIS 11 would require an ice mass loss equivalent to all of the modern Greenland and West Antarctic ice sheets; the more extreme estimates would require additional ice mass loss from the East Antarctic ice sheet. Extralimital southern species of mollusks, found in both MIS 11 and MIS 5.5 deposits on the Canary Islands, imply warmer-than-modern sea surface temperatures during at least a part of MIS 11 and much warmer sea surface temperatures during at least a part of MIS 5.5. Both MIS 11 and MIS 5.5 marine deposits on the Canary Islands contain extralimital northern species of mollusks as well, indicating cooler-than-present waters at times during these interglacial periods. We hypothesize that the co-occurrence of extralimital southern and northern species of marine invertebrates in the fossil record of the Canary Islands reflects its geographic location with respect to major synoptic-scale controls on climate and ocean currents. Previous interglacials may have been characterized by early, insolation-forced warming, along with northward migration of the intertropical convergence zone (ITCZ), accompanied by weakened trade winds and diminished upwelling. This allowed the arrival of extralimital southern taxa from the tropical Senegalese faunal province. During later parts of the MIS 11 and 5.5

Tumor-Specific Chromosome Mis-Segregation Controls Cancer Plasticity by Maintaining Tumor Heterogeneity

PubMed Central

Hu, Yuanjie; Ru, Ning; Xiao, Huasheng; Chaturbedi, Abhishek; Hoa, Neil T.; Tian, Xiao-Jun; Zhang, Hang; Ke, Chao; Yan, Fengrong; Nelson, Jodi; Li, Zhenzhi; Gramer, Robert; Yu, Liping; Siegel, Eric; Zhang, Xiaona; Jia, Zhenyu; Jadus, Martin R.; Limoli, Charles L.; Linskey, Mark E.; Xing, Jianhua; Zhou, Yi-Hong

2013-01-01

Aneuploidy with chromosome instability is a cancer hallmark. We studied chromosome 7 (Chr7) copy number variation (CNV) in gliomas and in primary cultures derived from them. We found tumor heterogeneity with cells having Chr7-CNV commonly occurs in gliomas, with a higher percentage of cells in high-grade gliomas carrying more than 2 copies of Chr7, as compared to low-grade gliomas. Interestingly, all Chr7-aneuploid cell types in the parental culture of established glioma cell lines reappeared in single-cell-derived subcultures. We then characterized the biology of three syngeneic glioma cultures dominated by different Chr7-aneuploid cell types. We found phenotypic divergence for cells following Chr7 mis-segregation, which benefited overall tumor growth in vitro and in vivo. Mathematical modeling suggested the involvement of chromosome instability and interactions among cell subpopulations in restoring the optimal equilibrium of tumor cell types. Both our experimental data and mathematical modeling demonstrated that the complexity of tumor heterogeneity could be enhanced by the existence of chromosomes with structural abnormality, in addition to their mis-segregations. Overall, our findings show, for the first time, the involvement of chromosome instability in maintaining tumor heterogeneity, which underlies the enhanced growth, persistence and treatment resistance of cancers. PMID:24282558

The Big 5: Teacher Knowledge and Skill Acquisition in Early Literacy

ERIC Educational Resources Information Center

Vesay, Joanne P.; Gischlar, Karen L.

2013-01-01

In this study, the investigators surveyed 215 early childhood educators throughout New Jersey and eastern Pennsylvania to determine teacher knowledge and training in early literacy instruction, with a focus on The 5 Big Ideas in Reading as identified by the National Reading Panel: phonological awareness, accuracy and fluency, alphabetic principle,…

Eemian and post-Eemian fluvial dynamics in the Lesser Caucasus

NASA Astrophysics Data System (ADS)

von Suchodoletz, Hans; Gärtner, Andreas; Zielhofer, Christoph; Faust, Dominik

2018-07-01

Mountain regions such as the Lesser Caucasus are a focus of ongoing environmental changes. To understand their future evolution, information about their former geomorphic and environmental dynamics is required. The former fluvial dynamics derived from fluvial sediment archives can offer such insights. However, the fluvial dynamics of the Lesser Caucasus since the Eemian interglacial have not been systematically investigated so far. Thus, we have studied late Pleistocene and Holocene sediments of several rivers originating from the central Lesser Caucasus. The studied rivers show a mostly coherent record of fluvial dynamics: Minor aggradation occurred during early Marine Isotope Stage (MIS) 5, incision during late MIS 5 or early MIS 4, intensive silty aggradation at least during late MIS 3, incision during early MIS 2, coarse-grained aggradation probably during some millenia until ca. 19 ka, and aggradation ca. 14-13 ka. Following incision around the Pleistocene/Holocene transition, aggradation resumed around 6.0, 3.4 - 2.0 and 0.5 - 0.15 cal. ka BP. Generally, periods of aggradation, incision and stability could be linked with regional climatic or anthropogenic influences on regional landscape stability and water availability. The fluvial dynamics of the central Lesser Caucasus mostly differed even between neighbouring regions, and only in cases of significant hemispheric climatic fluctuations as around 20 ka, during the Pleistocene/Holocene transition or the Little Ice Age, were similar over-regional fluvial patterns observed. This demonstrates the individual character of river systems especially in mountain regions such as the southern Caucasus with strong geoecological gradients. Thus, to understand the former landscape dynamics of mountain landscapes, investigations of fluvial sediment archives on a regional to sub-regional scale are necessary.

Childhood (Mis)Fortune, Educational Attainment, and Adult Health: Contingent Benefits of a College Degree?

ERIC Educational Resources Information Center

Schafer, Markus H.; Wilkinson, Lindsay R.; Ferraro, Kenneth F.

2013-01-01

College-educated adults are healthier than other people in the United States, but selection bias complicates our understanding of how education influences health. This article focuses on the possibility that the health benefits of college may vary according to childhood (mis)fortune and people's propensity to attain a college degree in the first…

Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE

PubMed Central

Wu, Yee Ling; Teichmann, Sarah A.

2017-01-01

Noncoding transcripts originating upstream of the immunoglobulin constant region (I transcripts) are required to direct activation-induced deaminase to initiate class switching in B cells. Differential regulation of Iε and Iγ1 transcription in response to interleukin 4 (IL-4), hence class switching to IgE and IgG1, is not fully understood. In this study, we combine novel mouse reporters and single-cell RNA sequencing to reveal the heterogeneity in IL-4–induced I transcription. We identify an early population of cells expressing Iε but not Iγ1 and demonstrate that early Iε transcription leads to switching to IgE and occurs at lower activation levels than Iγ1. Our results reveal how probabilistic transcription with a lower activation threshold for Iε directs the early choice of IgE versus IgG1, a key physiological response against parasitic infestations and a mediator of allergy and asthma. PMID:27994069

Ultrasound-guided microinjection into the mouse forebrain in utero at E9.5.

PubMed

Pierfelice, Tarran J; Gaiano, Nicholas

2010-11-13

In utero survival surgery in mice permits the molecular manipulation of gene expression during development. However, because the uterine wall is opaque during early embryogenesis, the ability to target specific parts of the embryo for microinjection is greatly limited. Fortunately, high-frequency ultrasound imaging permits the generation of images that can be used in real time to guide a microinjection needle into the embryonic region of interest. Here we describe the use of such imaging to guide the injection of retroviral vectors into the ventricular system of the mouse forebrain at embryonic day (E) 9.5. This method uses a laparotomy to permit access to the uterine horns, and a specially designed plate that permits host embryos to be bathed in saline while they are imaged and injected. Successful surgeries often result in most or all of the injected embryos surviving to any subsequent time point of interest (embryonically or postnatally). The principles described here can be used with slight modifications to perform injections into the amnionic fluid of E8.5 embryos (thereby permitting infection along the anterior posterior extent of the neural tube, which has not yet closed), or into the ventricular system of the brain at E10.5/11.5. Furthermore, at mid-neurogenic ages (~E13.5), ultrasound imaging can be used direct injection into specific brain regions for viral infection or cell transplantation. The use of ultrasound imaging to guide in utero injections in mice is a very powerful technique that permits the molecular and cellular manipulation of mouse embryos in ways that would otherwise be exceptionally difficult if not impossible.

The EDP-5E

ERIC Educational Resources Information Center

Lottero-Perdue, Pamela; Bolotin, Sonja; Benyameen, Ruth; Brock, Erin; Metzger, Ellen

2015-01-01

Many preservice and practicing elementary teachers are familiar with the 5E learning cycle. This cycle provides a relatively simple, alliteratively memorable framework for teaching science in which lessons (or even entire units of instruction) consist of five distinct phases: Engagement, Exploration, Explanation, Elaboration/Extension (hereafter,…

Timing of the onset of MIS 11 revealed by speleothem in southern Europe

NASA Astrophysics Data System (ADS)

Hu, Hsun-Ming; Shen, Chuan-Chou; Michel, Véronique; Kano, Akihiro

2017-04-01

The interglacial period, known as Marine Isotope Stage 11 (MIS 11, 428-397 thousand years ago), is often considered as a potential analogue for future climate projection because of the similar patterns of insolation variability. However, studies on mechanisms of the onset of MIS 11 (called Termination V, T-V) in response to insolation increase is still hampered by a lack of good dating materials in paleoclimate archives, despite a stack of East Asian monsoon records with precise U-Th dates has been proposed. Previous studies suggested the δ18O value registered in speleothems in Mediterranean realm can be a good bridge connecting the U-Th-based age model of speleothem to marine cores from Mediterranean sea, which opens a new possibility to detect ocean-atmosphere/internal-external forcing interaction beyond 14C dating limitation. Here we present a new speleothem δ18O record from northern Italy covering 500-300 thousand years ago. The results show a similar pattern with δ18O records of marine cores around Mediterranean. The age model of the speleothem hence provides an opportunity for tuning the marine cores, which could improve our understanding of relationship between global atmosphere and ocean circulations.

Analysis for orbital rendezvous of Chang'E-5 using SBI technique

NASA Astrophysics Data System (ADS)

Huang, Y.; Shan, Q.; Li, P.

2016-12-01

Chang'E-5 will be launched in later 2017/early 2018 using a new generation rocket from Wenchang satellite launch center, Hainan, China. It is a lunar sampling return mission, and it is the first time for China to carry out orbital rendezvous and docking in the Moon. How to achieve orbital rendezvous successfully in the Moon is very important in Chang'E-5 mission. Orbital rendezvous will be implemented between an orbiter and an ascender 200 km above the Moon. The ground tracking techniques include range, Doppler and VLBI, and they will be used to track the orbiter and the ascender when the ascender is about 70 km farther away from the orbiter. Later the ascender will approach the orbiter automatically. As a successful example, in Chang'E-3, the differential phase delay (delta delay) data between the rover and the lander are obtained with a random error of about 1 ps, and the relative position of the rover is determined with an accuracy of several meters by using same beam VLBI (SBI) technique. Here the application of the SBI technique for Chang'E-5 orbital rendezvous is discussed. SBI technique can be used to track the orbiter and the ascender simultaneously when they are in the same beam. Delta delay of the two probes can be derived, and the measurement accuracy is much higher than that of the traditional VLBI data because of the cancelation of common errors. Theoretically it can result in a more accurate relative orbit between the two probes. In the simulation, different strategies are discussed to analyze the contribution of SBI data to the orbit accuracy improvement especially relative orbit between the orbiter and ascender. The simulation results show that the relative position accuracy of the orbiter and ascender can reach about 1 m with delta delay data of 10 ps.

Early life IgE responses in children living in the tropics: a prospective analysis.

PubMed

Zakzuk, Josefina; Acevedo, Nathalie; Cifuentes, Liliana; Bornacelly, Adriana; Sánchez, Jorge; Ahumada, Velky; Ring, Johannes; Ollert, Markus; Caraballo, Luis

2013-12-01

There are few birth cohort studies analyzing IgE sensitization in the tropics. We aimed to describe the evolution of total IgE and specific IgE responses to house-dust mite (HDM) allergens and Ascaris in a birth cohort (Risk Factors for Asthma and Allergy in the Tropics, FRAAT), analyzing their relationships with wheezing. Total and specific IgE were measured by ImmunoCap in mothers and children at four different time points (S1-S4) between 0 and 42 months. Parasite infection was evaluated by stool examination. Maternal total IgE (aOR: 2.43, 95% CI: 1.09-5.43; p = 0.03) and socio-demographic factors were associated with high cord blood (CB) total IgE. High CB total IgE was positively associated with higher Blomia tropicalis and Ascaris-specific IgE values during lifetime, but protected from recurrent wheezing (aOR: 0.26, 95% CI: 0.08-0.88, p = 0.03). Prevalence rates of IgE sensitization were high; at around 3 yr old, they were 33.3, 18.6, and 26.5% for B. tropicalis, Dermatophagoides pteronyssinus, and Ascaris, respectively. Indicators of unhygienic conditions were risk factors for HDM and Ascaris sensitization in children. A weak statistical association between B. tropicalis-specific IgE and ever wheezing was found (aOR: 1.47 95% CI: 1.00-2.28, p = 0.05). In a socioeconomically deprived community from the tropics, sensitization to HDM allergens was very frequent at early life, especially to B. tropicalis. In contrast to expected according to the hygiene hypothesis, unhygienic/poverty conditions were risk factors for allergen sensitization. High CB total IgE levels were a risk factor for allergen sensitization but protected from recurrent wheezing. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

"Generality of mis-fit"? The real-life difficulty of matching scales in an interconnected world.

PubMed

Keskitalo, E Carina H; Horstkotte, Tim; Kivinen, Sonja; Forbes, Bruce; Käyhkö, Jukka

2016-10-01

A clear understanding of processes at multiple scales and levels is of special significance when conceiving strategies for human-environment interactions. However, understanding and application of the scale concept often differ between administrative-political and ecological disciplines. These mirror major differences in potential solutions whether and how scales can, at all, be made congruent. As a result, opportunities of seeking "goodness-of-fit" between different concepts of governance should perhaps be reconsidered in the light of a potential "generality of mis-fit." This article reviews the interdisciplinary considerations inherent in the concept of scale in its ecological, as well as administrative-political, significance and argues that issues of how to manage "mis-fit" should be awarded more emphasis in social-ecological research and management practices. These considerations are exemplified by the case of reindeer husbandry in Fennoscandia. Whilst an indigenous small-scale practice, reindeer husbandry involves multi-level ecological and administrative-political complexities-complexities that we argue may arise in any multi-level system.

Middle Palaeolithic occupation in the Thar Desert during the Upper Pleistocene: the signature of a modern human exit out of Africa?

NASA Astrophysics Data System (ADS)

Blinkhorn, James; Achyuthan, Hema; Petraglia, Michael; Ditchfield, Peter

2013-10-01

The Thar Desert marks the transition from the Saharo-Arabian deserts to the Oriental biogeographical zone and is therefore an important location in understanding hominin occupation and dispersal during the Upper Pleistocene. Here, we report the discovery of stratified Middle Palaeolithic assemblages at Katoati in the north-eastern Thar Desert, dating to Marine Isotope Stages (MIS) 5 and the MIS 4-3 boundary, during periods of enhanced humidity. Hominins procured cobbles from gravels at the site as evidenced by early stages of stone tool reduction, with a component of more formalised point production. The MIS 5c assemblages at Katoati represent the earliest securely dated Middle Palaeolithic occupation of South Asia. Distinctive artefacts identified in both MIS 5 and MIS 4-3 boundary horizons match technological entities observed in Middle Palaeolithic assemblages in South Asia, Arabia and Middle Stone Age sites in the Sahara. The evidence from Katoati is consistent with arguments for the dispersal of Homo sapiens populations from Africa across southern Asia using Middle Palaeolithic technologies.

Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5

PubMed Central

Henry, Margit; Rotshteyn, Tamara; Brunn, Anna; Carstov, Mariana; Deckert, Martina; Hescheler, Jürgen; Sachinidis, Agapios; Pfitzer, Gabriele

2018-01-01

In skeletal muscle the coordinated actions of two mechanically coupled Ca2+ channels—the 1,4-dihydropyridine receptor (Cav1.1) and the type 1 ryanodine receptor (RYR1)–underlie the molecular mechanism of rapid cytosolic [Ca2+] increase leading to contraction. While both [Ca2+]i and contractile activity have been implicated in the regulation of myogenesis, less is known about potential specific roles of Cav1.1 and RYR1 in skeletal muscle development. In this study, we analyzed the histology and the transcriptomic changes occurring at E14.5 –the end of primary myogenesis and around the onset of intrauterine limb movement, and at E18.5 –the end of secondary myogenesis, in WT, RYR1-/-, and Cav1.1-/- murine limb skeletal muscle. At E14.5 the muscle histology of both mutants exhibited initial alterations, which became much more severe at E18.5. Immunohistological analysis also revealed higher levels of activated caspase-3 in the Cav1.1-/- muscles at E14.5, indicating an increase in apoptosis. With WT littermates as controls, microarray analyses identified 61 and 97 differentially regulated genes (DEGs) at E14.5, and 493 and 1047 DEGs at E18.5, in RYR1-/- and Cav1.1-/- samples, respectively. Gene enrichment analysis detected no overlap in the affected biological processes and pathways in the two mutants at E14.5, whereas at E18.5 there was a significant overlap of DEGs in both mutants, affecting predominantly processes linked to muscle contraction. Moreover, the E18.5 vs. E14.5 comparison revealed multiple genotype-specific DEGs involved in contraction, cell cycle and miRNA-mediated signaling in WT, neuronal and bone development in RYR1-/-, and lipid metabolism in Cav1.1-/- samples. Taken together, our study reveals discrete changes in the global transcriptome occurring in limb skeletal muscle from E14.5 to E18.5 in WT, RYR1-/- and Cav1.1-/- mice. Our results suggest distinct functional roles for RYR1 and Cav1.1 in skeletal primary and secondary myogenesis. PMID

Climatic evolution of Marine Isotope Stage 5 and particularly the Eemian reconstructed from precisely dated speleothems from western Germany

NASA Astrophysics Data System (ADS)

Scholz, Denis; Hoffmann, Dirk L.; Spötl, Christoph; Hopcroft, Peter; Jochum, Klaus Peter; Richter, Detlev K.

2015-04-01

We present high-resolution δ18O, δ13C and trace element profiles for three stalagmites from western Germany, which grew during Marine Isotope Stage (MIS) 5. All stalagmites were precisely dated by MC-ICPMS 230Th/U-dating. Stalagmite HBSH-1 from Hüttenbläserschachthöhle grew between 130 and 80 ka and provides a climate record with decadal to centennial resolution. The other two stalagmites grew faster than HBSH 1, but their growth phases are shorter. Stalagmite HBSH 5 grew between 129 and 122 ka, whereas stalagmite BR 5 grew between 126 and 122 ka. The record of HBSH 1 shows four growth interruptions coinciding with Greenland Stadials (GS) 21, 22, 24, 25, and 26. This shows that stalagmite growth is a very sensitive proxy for cool and dry conditions in the northern hemisphere and enables us to precisely determine the timing and duration of the GS. We interpret stalagmite δ18O values as a proxy for supra-regional temperature changes in the North Atlantic realm, which is paticularly evident from their close resemblance with the δ18O values of the NGRIP and NEEM ice core records. Stalagmite δ13C values primarily reflect changes in hydrological balance and (local) vegetation and are, thus, a proxy for terrestrial climate change in central European. The δ13C record shows three pronounced negative peaks during MIS 5, and their timing is in agreement with MIS 5e, 5c and 5a. This suggests generally warm and humid climate in central Europe during these phases. The evolution of the δ18O and δ13C values during the Eemian is not parallel. The δ18O values progressively increase from 130 ka, peak at 125 ka and subsequently show a gradual decrease. The δ13C values, in contrast, start to decrease at 123 ka, show a negative peak at 120 ka and an aprupt increase at 114 ka. This suggests that the Eemian sensu strictu lasted from 124 to 114 ka, in agreement with a marine record from the Norwegian Sea and indicates and a strong influence on central European climate from

Diurnal variation in myocardial ischemia/reperfusion tolerance; mediation by the circadian clock within the cardiomyocyte

USDA-ARS?s Scientific Manuscript database

Circadian rhythms in cardiovascular physiology (e.g. blood pressure and heart rate) and pathophysiology (e.g. myocardial infarction (MI)) exist. Humans exhibit a marked increase in MI frequency during the early hours of the morning. However, MIs occurring during the evening are more likely to result...

The Acheulian and Early Middle Paleolithic in Latium (Italy): Stability and Innovation.

PubMed

Villa, Paola; Soriano, Sylvain; Grün, Rainer; Marra, Fabrizio; Nomade, Sebastien; Pereira, Alison; Boschian, Giovanni; Pollarolo, Luca; Fang, Fang; Bahain, Jean-Jacques

2016-01-01

We present here the results of a technological and typological analysis of the Acheulian and early Middle Paleolithic assemblages from Torre in Pietra (Latium, Italy) together with comparisons with the Acheulian small tools of Castel di Guido. The assemblages were never chronometrically dated before. We have now 40Ar/39Ar dates and ESR-U-series dates, within a geomorphological framework, which support correlations to marine isotope stages. The Acheulian (previously correlated to MIS 9) is now dated to MIS 10 while the Middle Paleolithic is dated to MIS 7. Lithic analyses are preceded by taphonomic evaluations. The Levallois method of the Middle Paleolithic assemblage is an innovation characterized by the production of thin flake blanks without cortex. In contrast, the small tool blanks of the Acheulian were either pebbles or thick flakes with some cortex. They provided a relatively easy manual prehension. The choice of Levallois thin flake blanks in the Middle Paleolithic assemblage suggest that the new technology is most likely related to the emergence of hafting. Accordingly, the oldest direct evidence of hafting technology is from the site of Campitello Quarry in Tuscany (Central Italy) where birch-bark tar, found on the proximal part of two flint flakes, is dated to the end of MIS 7. Nevertheless, a peculiar feature of the Middle Paleolithic at Torre in Pietra is the continuous presence of small tool blanks on pebbles and cores and on thick flake albeit at a much lower frequency than in the older Acheulian industries. The adoption of the new technology is thus characterized by innovation combined with a degree of stability. The persistence of these habits in spite of the introduction of an innovative technique underlies the importance of cultural transmission and conformity in the behavior of Neandertals.

The Acheulian and Early Middle Paleolithic in Latium (Italy): Stability and Innovation

PubMed Central

Soriano, Sylvain; Grün, Rainer; Marra, Fabrizio; Nomade, Sebastien; Pereira, Alison; Boschian, Giovanni; Pollarolo, Luca; Fang, Fang; Bahain, Jean-Jacques

2016-01-01

We present here the results of a technological and typological analysis of the Acheulian and early Middle Paleolithic assemblages from Torre in Pietra (Latium, Italy) together with comparisons with the Acheulian small tools of Castel di Guido. The assemblages were never chronometrically dated before. We have now 40Ar/39Ar dates and ESR-U-series dates, within a geomorphological framework, which support correlations to marine isotope stages. The Acheulian (previously correlated to MIS 9) is now dated to MIS 10 while the Middle Paleolithic is dated to MIS 7. Lithic analyses are preceded by taphonomic evaluations. The Levallois method of the Middle Paleolithic assemblage is an innovation characterized by the production of thin flake blanks without cortex. In contrast, the small tool blanks of the Acheulian were either pebbles or thick flakes with some cortex. They provided a relatively easy manual prehension. The choice of Levallois thin flake blanks in the Middle Paleolithic assemblage suggest that the new technology is most likely related to the emergence of hafting. Accordingly, the oldest direct evidence of hafting technology is from the site of Campitello Quarry in Tuscany (Central Italy) where birch-bark tar, found on the proximal part of two flint flakes, is dated to the end of MIS 7. Nevertheless, a peculiar feature of the Middle Paleolithic at Torre in Pietra is the continuous presence of small tool blanks on pebbles and cores and on thick flake albeit at a much lower frequency than in the older Acheulian industries. The adoption of the new technology is thus characterized by innovation combined with a degree of stability. The persistence of these habits in spite of the introduction of an innovative technique underlies the importance of cultural transmission and conformity in the behavior of Neandertals. PMID:27525705

Whose Quality? The (Mis)Uses of Quality Reform in Early Childhood and Education Policy

ERIC Educational Resources Information Center

Hunkin, Elise

2018-01-01

This paper reports on the findings of an in-depth genealogical study of the discourse of quality in Australian Early Childhood Education and Care (ECEC) policy. Quality reform has become the foremost global policy agenda for ECEC due to assumptions about the economic potentials of quality services. In Australia, the recent National Quality…

Uranium uptake history, open-system behaviour and uranium-series ages of fossil Tridacna gigas from Huon Peninsula, Papua New Guinea

NASA Astrophysics Data System (ADS)

Ayling, Bridget F.; Eggins, Stephen; McCulloch, Malcolm T.; Chappell, John; Grün, Rainer; Mortimer, Graham

2017-09-01

Molluscs incorporate negligible uranium into their skeleton while they are living, with any uranium uptake occurring post-mortem. As such, closed-system U-series dating of molluscs is unlikely to provide reliable age constraints for marine deposits. Even the application of open-system U-series modelling is challenging, because uranium uptake and loss histories can affect time-integrated uranium distributions and are difficult to constrain. We investigate the chemical and isotopic distribution of uranium in fossil Tridacna gigas (giant clams) from Marine Isotope Stage (MIS) 5e (128-116 ka) and MIS 11 (424-374 ka) reefs at Huon Peninsula in Papua New Guinea. The large size of the clams enables detailed chemical and isotopic mapping of uranium using LA-ICPMS and LA-MC-ICPMS techniques. Within each fossil Tridacna specimen, marked differences in uranium concentrations are observed across the three Tridacna growth zones (outer, inner, hinge), with the outer and hinge zones being relatively enriched. In MIS 5e and MIS 11 Tridacna, the outer and hinge zones contain approximately 1 ppm and 5 ppm uranium respectively. In addition to uptake of uranium, loss of uranium appears prevalent, especially in the MIS 11 specimens. The effect of uranium loss is to elevate measured [230Th/238U] values with little effect on [234U/238U] values. Closed-system age estimates are on average 50% too young for the MIS 5e Tridacna, and 25% too young for the MIS 11 Tridacna. A complex, multi-stage uptake and loss history is interpreted for the fossil Tridacna and we demonstrate that they cannot provide independent, reliable geochronological controls on the timing of past reef growth at Huon Peninsula.

MIS High-Purity Plutonium Oxide Hydride Product 5501579 (SSR124): Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Veirs, Douglas Kirk; Stroud, Mary Ann; Berg, John M.

A high-purity plutonium dioxide material from the Material Identification and Surveillance (MIS) Program inventory has been studied with regard to gas generation and corrosion in a storage environment. Sample 5501579 represents process plutonium oxides from hydride oxide from Rocky Flats that are currently stored in 3013 containers. After calcination to 950°C, the material contained 87.42% plutonium with no major impurities. This study followed over time, the gas pressure of a sample with nominally 0.5 wt% water in a sealed container with an internal volume scaled to 1/500th of the volume of a 3013 container. Gas compositions were measured periodically overmore » a six year period. The maximum observed gas pressure was 124 kPa. The increase over the initial pressure of 70 kPa was primarily due to generation of nitrogen and carbon dioxide gas. Hydrogen and oxygen were minor components of the headspace gas. At the completion of the study, the internal components of the sealed container showed signs of corrosion.« less

A role for HPV16 E5 in cervical carcinogenesis.

PubMed

Maufort, John P; Shai, Anny; Pitot, Henry C; Lambert, Paul F

2010-04-01

A subset of the mucosotropic human papillomaviruses (HPV), including HPV16, are etiologic agents for the vast majority of cervical cancers, other anogenital cancers, and a subset of head and neck squamous cell carcinomas. HPV16 encodes three oncogenes: E5, E6, and E7. Although E6 and E7 have been well-studied and clearly shown to be important contributors to these cancers, less is known about E5. In this study, we used E5 transgenic mice to investigate the role of E5 in cervical cancer. When treated for 6 months with estrogen, a cofactor for cervical carcinogenesis, E5 transgenic mice developed more severe neoplastic cervical disease than similarly treated nontransgenic mice, although no frank cancers were detected. In addition, E5 when combined with either E6 or E7 induced more severe neoplastic disease than seen in mice expressing only one viral oncogene. Prolonged treatment of E5 transgenic mice with exogenous estrogen uncovered an ability of E5 to cause frank cancer. These data indicate that E5 acts as an oncogene in the reproductive tracts of female mice.

Comparative Diagnostic Accuracy of the ACE-III, MIS, MMSE, MoCA, and RUDAS for Screening of Alzheimer Disease.

PubMed

Matías-Guiu, Jordi A; Valles-Salgado, María; Rognoni, Teresa; Hamre-Gil, Frank; Moreno-Ramos, Teresa; Matías-Guiu, Jorge

2017-01-01

Our aim was to evaluate and compare the diagnostic properties of 5 screening tests for the diagnosis of mild Alzheimer disease (AD). We conducted a prospective and cross-sectional study of 92 patients with mild AD and of 68 healthy controls from our Department of Neurology. The diagnostic properties of the following tests were compared: Mini-Mental State Examination (MMSE), Addenbrooke's Cognitive Examination III (ACE-III), Memory Impairment Screen (MIS), Montreal Cognitive Assessment (MoCA), and Rowland Universal Dementia Assessment Scale (RUDAS). All tests yielded high diagnostic accuracy, with the ACE-III achieving the best diagnostic properties. The area under the curve was 0.897 for the ACE-III, 0.889 for the RUDAS, 0.874 for the MMSE, 0.866 for the MIS, and 0.856 for the MoCA. The Mini-ACE score from the ACE-III showed the highest diagnostic capacity (area under the curve 0.939). Memory scores of the ACE-III and of the RUDAS showed a better diagnostic accuracy than those of the MMSE and of the MoCA. All tests, especially the ACE-III, conveyed a higher diagnostic accuracy in patients with full primary education than in the less educated group. Implementing normative data improved the diagnostic accuracy of the ACE-III but not that of the other tests. The ACE-III achieved the highest diagnostic accuracy. This better discrimination was more evident in the more educated group. © 2017 S. Karger AG, Basel.

Splice Site Variants in the KCNQ1 and SCN5A Genes: Transcript Analysis as a Tool in Supporting Pathogenicity

PubMed Central

Leong, Ivone U.S.; Dryland, Philippa A.; Prosser, Debra O.; Lai, Stella W.-S.; Graham, Mandy; Stiles, Martin; Crawford, Jackie; Skinner, Jonathan R.; Love, Donald R.

2017-01-01

Background Approximately 75% of clinically definite long QT syndrome (LQTS) cases are caused by mutations in the KCNQ1, KCNH2 and SCN5A genes. Of these mutations, a small proportion (3.2-9.2%) are predicted to affect splicing. These mutations present a particular challenge in ascribing pathogenicity. Methods Here we report an analysis of the transcriptional consequences of two mutations, one in the KCNQ1 gene (c.781_782delinsTC) and one in the SCN5A gene (c.2437-5C>A), which are predicted to affect splicing. We isolated RNA from lymphocytes and used a directed PCR amplification strategy of cDNA to show mis-spliced transcripts in mutation-positive patients. Results The loss of an exon in each mis-spliced transcript had no deduced effect on the translational reading frame. The clinical phenotype corresponded closely with genotypic status in family members carrying the KCNQ1 splice variant, but not in family members with the SCN5A splice variant. These results are put in the context of a literature review, where only 20% of all splice variants reported in the KCNQ1, KCNH2 and SCN5A gene entries in the HGMDPro 2015.4 database have been evaluated using transcriptional assays. Conclusions Prediction programmes play a strong role in most diagnostic laboratories in classifying variants located at splice sites; however, transcriptional analysis should be considered critical to confirm mis-splicing. Critically, this study shows that genuine mis- splicing may not always imply clinical significance, and genotype/phenotype cosegregation remains important even when mis-splicing is confirmed. PMID:28725320

Cooperative transformation and coexpression of bovine papillomavirus type 1 E5 and E7 proteins.

PubMed

Bohl, J; Hull, B; Vande Pol, S B

2001-01-01

Productively infected bovine fibropapillomas were examined for bovine papillomavirus type 1 (BPV-1) E7 localization. BPV-1 E7 was observed in the cytoplasm of basal and lower spinous epithelial cells, coexpressed in the cytoplasm of basal cells with the E5 oncoprotein. E7 was also observed in nucleoli throughout the basal and spinous layers but not in the granular cell layer. Ectopic expression of E7 in cultured epithelial cells gave rise to localization similar to that seen in productive fibropapillomas, with cytoplasmic and nucleolar expression observed. Consistent with the coexpression of E7 and E5 in basal keratinocytes, BPV-1 E7 cooperated with E5 as well as E6 in an anchorage independence transformation assay. While E5 is expressed in both basal and superficial differentiating keratinocytes, BPV-1 E7 is only observed in basal and lower spinous epithelial cells. Therefore, BPV-1 E7 may serve to modulate the cellular response of basal epithelial cells to E5 expression.

Mechanism of leakage of ion-implantation isolated AlGaN/GaN MIS-high electron mobility transistors on Si substrate

NASA Astrophysics Data System (ADS)

Zhang, Zhili; Song, Liang; Li, Weiyi; Fu, Kai; Yu, Guohao; Zhang, Xiaodong; Fan, Yaming; Deng, Xuguang; Li, Shuiming; Sun, Shichuang; Li, Xiajun; Yuan, Jie; Sun, Qian; Dong, Zhihua; Cai, Yong; Zhang, Baoshun

2017-08-01

In this paper, we systematically investigated the leakage mechanism of the ion-implantation isolated AlGaN/GaN metal-insulator-semiconductor high electron mobility transistors (MIS-HEMTs) on Si substrate. By means of combined DC tests at different temperatures and electric field dependence, we demonstrated the following original results: (1) It is proved that gate leakage is the main contribution to OFF-state leakage of ion-implantation isolated AlGaN/GaN MIS-HEMTs, and the gate leakage path is a series connection of the gate dielectric Si3N4 and Si3N4-GaN interface. (2) The dominant mechanisms of the leakage current through LPCVD-Si3N4 gate dielectric and Si3N4-GaN interface are identified to be Frenkel-Poole emission and two-dimensional variable range hopping (2D-VRH), respectively. (3) A certain temperature annealing could reduce the density of the interface state that produced by ion implantation, and consequently suppress the interface leakage transport, which results in a decrease in OFF-state leakage current of ion-implantation isolated AlGaN/GaN MIS-HEMTs.

The Alleret Maar lacustrine sequence (French Massif Central): a 150 ka long early-middle Pleistocene continental paleoenvironmental record.

NASA Astrophysics Data System (ADS)

Nomade, S.; Pastre, J.; Guillou, H.; Gauthier, A.; Scaillet, S.

2008-12-01

Lacustrine maar sequences of the French Massif Central are of great interest for paleoclimatic and paleoenvironmental reconstructions of mid-latitudes Quaternary continental environments. In particular, the western Velay region yields exceptional sequences spanning the last 450 ka (Reille et al., J. Quat. Sci. 2000). However, older sequences remain largely unknown despite the presence of interbedded alkaline tephras allowing precise absolute radiochronological control of many lacustrine squences. The Alleret maar is a 1500 m wide phreatomagmatic crater that provides a long lacustrine sequence (41 m). The upper part of this sequence (AL2 core, 14.6 m) was studied between 2005 and 2006 (Pastre et al., C. R. Acad Sci, 2007). A 39Ar/40Ar date (557 ± 5ka) obtained from an interbedded tephra layer located at 7m as well as the associated pollen data attribute the beginning of this sequence to the MIS 15. Thanks to the AL3 core recovered in 2005 (40.6 m, CNRS Meudon) several new tephra layers were discovered in the bottom part of this lacustrine sequence. Three new 39Ar/40Ar ages (single crystal analyses) from trachytic tephra layers were obtained at the LSCE Argon Laboratory (France). These layers are located at -30.2, -36.2 and -39.2m. Ages obtained relative to the ACR-2 flux standard (1,201Ma, Kuiper et al., Science, 2008) range from 692 ± 6 ka (MSWD: 2.3, n=18) for the youngest (-30.2m) to 726 ± 9Ka Ka (MSWD: 2.2, n=12) for the lowest tephra located at -39.2m. These new dates indicate a relatively homogeneous deposition rate of 3.5cm/ka and that the last 10 meters cover the MIS 17-MIS18 period. According to these current radiochronological data the complete lacustrine sequence last more than 150ka. Ongoing sedimentary and pollen studies will allow to extend the paleoenvironmental and paleoclimatic records of the French Massif Central towards the beginning of the early middle Pleistocene.

An Activity Theory Approach to Analyze Barriers to a Virtual Management Information Systems (MIS) Curriculum

ERIC Educational Resources Information Center

Jaradat, Suhair; Qablan, Ahmad; Barham, Areej

2011-01-01

This paper explains how the activity theory is used as a framework to analyze the barriers to a virtual Management Information Stream (MIS) Curriculum in Jordanian schools, from both the sociocultural and pedagogical perspectives. Taking the activity system as a unit of analysis, this study documents the processes by which activities shape and are…

32 CFR Appendix E to Part 57 - DoD-CC on Early Intervention, Special Education, and Related Services

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false DoD-CC on Early Intervention, Special Education... SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN PROVISION OF EARLY INTERVENTION AND SPECIAL EDUCATION SERVICES TO ELIGIBLE DOD DEPENDENTS Pt. 57, App. E Appendix E to Part 57—DoD-CC on Early Intervention...

32 CFR Appendix E to Part 57 - DoD-CC on Early Intervention, Special Education, and Related Services

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false DoD-CC on Early Intervention, Special Education... SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN PROVISION OF EARLY INTERVENTION AND SPECIAL EDUCATION SERVICES TO ELIGIBLE DOD DEPENDENTS Pt. 57, App. E Appendix E to Part 57—DoD-CC on Early Intervention...

32 CFR Appendix E to Part 57 - DoD-CC on Early Intervention, Special Education, and Related Services

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false DoD-CC on Early Intervention, Special Education... SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN PROVISION OF EARLY INTERVENTION AND SPECIAL EDUCATION SERVICES TO ELIGIBLE DOD DEPENDENTS Pt. 57, App. E Appendix E to Part 57—DoD-CC on Early Intervention...

New insights into the paleolake sequence of Baumkirchen (Austria): multiple lake phases and a minor ice advance during MIS 4?

NASA Astrophysics Data System (ADS)

Barrett, Samuel; Starnberger, Reinhard; Spötl, Christoph; Brauer, Achim; Tjallingii, Rik; Dulski, Peter; Abfalterer, Christof

2015-04-01

The sequence of pre-LGM lacustrine sediments at Baumkirchen (Austria) provides a key record in Alpine Quaternary stratigraphy. These sediments from within the boundary of the Alps potentially provide unique insights into the regional paleoclimate. Recent drilling revealed at least ~250m (the base was not reached) of almost entirely mm- to cm-scale lacustrine sediments. The laminated sediments are comprised of alternations between clayey silt and event layers of medium silt to fine sand. The sequence is interrupted only by a short section of gravel supported in an unlaminated clay-rich matrix. Optically stimulated luminescence dating identifies two distinct sequences: the upper sequence spanning mid-late Marine Isotope Stage (MIS) 3 (~33 to ~45 ka BP), agreeing with existing calibrated radiocarbon ages, and the lower section dating to MIS 4 (~59 to ~73 ka BP). Whether the hiatus is an erosional unconformity, or if the sequences represent two separate lake phases is unclear. Although the precise location of the hiatus is hard to identify, the gravel-rich section lies at the very top of the lower sequence. Pebbles in these gravels are largely angular and contain a significant proportion of non-local, regional lithologies. Such gravels are absent in the remainder of the entire 250 m-thick sequence and hence suggest a unique event rather than e.g. an interfingering local delta gravel foresets with the basin sediments. The gravels are therefore likely to be ice-rafted debris from icebergs from nearby glaciers calving into the lake. This therefore represents the first sedimentological evidence of a MIS 4 ice advance in the Eastern Alps. X-ray fluorescence analysis (ITRAX core scanning) of event layers indicates a strong change in the geochemical composition from generally K, Zr and Ti-rich layers in the upper sequence to mainly Ca and/or Si-rich layers in the lower sequence. X-ray diffraction analysis shows the Ca and Si signals to be controlled by carbonate (both calcite

Did the Laurentide ice sheet survive through Marine Isotope Stage 9?

NASA Astrophysics Data System (ADS)

Carlson, A. E.; Tarasov, L.; Ullman, D. J.

2016-12-01

Looking at the global benthic oxygen isotope stack, only marine oxygen isotope stage (MIS) 7 stands out as an anomalous interglaciation with a higher oxygen isotope value than other interglaciations of the last half million years. However, benthic oxygen isotopes are an integrator of global ice volume plus temperature, and records of local ice-sheet change are needed to partition the sources of the global signal. Here we use the Laurentide ice-sheet (LIS) proximal record of IODP Site U1302/1303 off of Orphan Knoll to test LIS presence/absence on the eastern Canadian shield. Ice-sheet model calibrated Si relative to Sr is low in most interglaciations of the last 500 ka reflecting the removal of the LIS and its erosive power from the Canadian Shield. However, like MIS 7, MIS 9 has continued elevated inputs of Si. Furthermore, planktic oxygen isotopes do not decrease to full interglacial levels like in MIS 1, 5e and 11. MIS 9 had a similar orbital forcing as MIS 5e, but a much shorter period of elevated interglacial carbon dioxide concentration. Based on climate model simulations of LIS stability, we suggest that the reduced period of elevated atmospheric carbon dioxide allowed the LIS to survive through MIS 9 (like MIS 7), providing important constraints for the climatic thresholds necessary for a full interglaciation.

MIS diode structure in As/+/ implanted CdS

NASA Technical Reports Server (NTRS)

Hutchby, J. A.

1977-01-01

Structure made by As implantation of carefully prepared high-conductivity CdS surfaces followed by Pt deposition and 450 C anneal display rectifying, although substantially different, I-V characteristics in the dark and during illumination with subband-gap light. Structures prepared in the same way on an unimplanted portion of the substrate have similar I-V characteristics, except that the forward turnover voltage for an illuminated unimplanted diode is much smaller than that for an implanted diode. It is suggested that the charge conduction in both structures is dominated by hole and/or electron tunneling through a metal-semiconductor potential barrier. The tunneling processes appear to be quite sensitive to subband-gap illumination, which causes the dramatic decreases of turnover voltages and apparent series resistances. The difference in turnover voltage appears to be caused by interface states between the Pt electrode and the implanted layer, which suggests a MIS model.

Middle to Late Pleistocene environmental and climatic reconstruction of the human occurrence at Grotta Maggiore di San Bernardino (Vicenza, Italy) through the small-mammal assemblage

NASA Astrophysics Data System (ADS)

López-García, Juan Manuel; Luzi, Elisa; Peresani, Marco

2017-07-01

Grotta Maggiore di San Bernardino, located at an altitude of 135 m a.s.l. in the Berici Hills in northeastern Italy, is an archaeological site with a discontinuous sedimentary sequence dating from Marine Isotope Stage 7 (MIS 7) to MIS 3. In this paper we present for the first time a palaeoenvironmental and palaeoclimatic reconstruction of the sequence based on small-mammal (insectivore, bat and rodent) assemblages. Coupled with biochronological data and absolute dating together with previous studies on large mammals, birds and other studies on small mammals and pollen from comparable time-spans in Italy, the results enable us clearly to identify distinct climatic periods: the end of MIS 7 (7c to 7a) in units VIII-VII, MIS 5d in unit V, and probably MIS 5b in unit IV and an indeterminate MIS 3 interstadial in units III-II. Finally, the study shows that the early Middle Palaeolithic human occupation in Italy occurs during mild and temperate sub-stages of MIS 7 and that human groups with the same techno-cultural background (Mousterian) were well adapted to the changing environmental and climatic conditions of the Middle to Late Pleistocene in this part of southern Europe.

FKBP5 genotype interacts with early life trauma to predict heavy drinking in college students.

PubMed

Lieberman, Richard; Armeli, Stephen; Scott, Denise M; Kranzler, Henry R; Tennen, Howard; Covault, Jonathan

2016-09-01

Alcohol use disorder (AUD) is debilitating and costly. Identification and better understanding of risk factors influencing the development of AUD remain a research priority. Although early life exposure to trauma increases the risk of adulthood psychiatric disorders, including AUD, many individuals exposed to early life trauma do not develop psychopathology. Underlying genetic factors may contribute to differential sensitivity to trauma experienced in childhood. The hypothalamic-pituitary-adrenal (HPA) axis is susceptible to long-lasting changes in function following childhood trauma. Functional genetic variation within FKBP5, a gene encoding a modulator of HPA axis function, is associated with the development of psychiatric symptoms in adulthood, particularly among individuals exposed to trauma early in life. In the current study, we examined interactions between self-reported early life trauma, past-year life stress, past-year trauma, and a single nucleotide polymorphism (rs1360780) in FKBP5 on heavy alcohol consumption in a sample of 1,845 college students from two university settings. Although we found no effect of early life trauma on heavy drinking in rs1360780*T-allele carriers, rs1360780*C homozygotes exposed to early life trauma had a lower probability of heavy drinking compared to rs1360780*C homozygotes not exposed to early life trauma (P < 0.01). The absence of an interaction between either current life stress or past-year trauma, and FKBP5 genotype on heavy drinking suggests that there exists a developmental period of susceptibility to stress that is moderated by FKBP5 genotype. These findings implicate interactive effects of early life trauma and FKBP5 genetic variation on heavy drinking. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Rabies virus co-localizes with early (Rab5) and late (Rab7) endosomal proteins in neuronal and SH-SY5Y cells.

PubMed

Ahmad, Waqas; Li, Yingying; Guo, Yidi; Wang, Xinyu; Duan, Ming; Guan, Zhenhong; Liu, Zengshan; Zhang, Maolin

2017-06-01

Rabies virus (RABV) is a highly neurotropic virus that follows clathrin-mediated endocytosis and pH-dependent pathway for trafficking and invasion into endothelial cells. Early (Rab5, EEA1) and late (Rab7, LAMP1) endosomal proteins play critical roles in endosomal sorting, maturity and targeting various molecular cargoes, but their precise functions in the early stage of RABV neuronal infection remain elusive. In this study, the relationship between enigmatic entry of RABV with these endosomal proteins into neuronal and SH-SY5Y cells was investigated. Immunofluorescence, TCID 50 titers, electron microscopy and western blotting were carried out to determine the molecular interaction of the nucleoprotein (N) of RABV with early or late endosomal proteins in these cell lines. The expression of N was also determined by down-regulating Rab5 and Rab7 in both cell lines through RNA interference. The results were indicative that N proficiently colocalized with Rab5/EEA1 and Rab7/LAMP1 in both cell lines at 24 and 48 h post-infection, while N titers significantly decreased in early infection of RABV. Down-regulation of Rab5 and Rab7 did not inhibit N expression, but it prevented productive infection via blocking the normal trafficking of RABV in a low pH environment. Ultrathin sections of cells studied by electron microscope also verified the close association of RABV with Rab5 and Rab7 in neurons. From the data it was concluded that primary entry of RABV strongly correlates with the kinetics of Rab-proteins present on early and late vesicles, which provides helpful clues to explain the early events of RABV in nerve cells.

29 CFR 2584.8477(e)-5 - Effect of allocation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Effect of allocation. 2584.8477(e)-5 Section 2584.8477(e)-5 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF... REGULATIONS FOR THE ALLOCATION OF FIDUCIARY RESPONSIBILITY § 2584.8477(e)-5 Effect of allocation. Where...

5,6-Dehydrokawain from Alpinia zerumbet promotes osteoblastic MC3T3-E1 cell differentiation.

PubMed

Kumagai, Momochika; Mishima, Takashi; Watanabe, Akio; Harada, Teppei; Yoshida, Izumi; Fujita, Kazuhiro; Watai, Masatoshi; Tawata, Shinkichi; Nishikawa, Keisuke; Morimoto, Yoshiki

2016-07-01

Bone homeostasis is maintained by balancing bone formation and bone resorption, but an imbalance between them is associated with various bone-related diseases such as osteoporosis and rheumatoid arthritis. We found that 5,6-dehydrokawain (DK) and dihydro-5,6-dehydrokawain (DDK), which were isolated as promising compounds from Alpinia zerumbet rhizomes, promote differentiation of osteoblastic MC3T3-E1 cells. DK and DDK increased the alkaline phosphatase activity and matrix mineralization of MC3T3-E1 cells. DK exerts larger effects than DDK. The gene expression of runt-related transcription factor 2 and osterix, which are essential transcription factors in the early period of osteoblast differentiation, was significantly increased by DK treatment. The mRNA level of distal-less homeobox 5 was also enhanced by DK treatment, and DK activated the p38 mitogen-activated protein kinase pathway. Therefore, DK may have clinical potential for preventing osteoporosis, and could be considered as a potential anabolic therapeutic agent.

Volcanic synchronization of Dome Fuji and Dome C Antarctic deep ice cores over the past 216 kyr

NASA Astrophysics Data System (ADS)

Fujita, S.; Parrenin, F.; Severi, M.; Motoyama, H.; Wolff, E. W.

2015-10-01

Two deep ice cores, Dome Fuji (DF) and EPICA Dome C (EDC), drilled at remote dome summits in Antarctica, were volcanically synchronized to improve our understanding of their chronologies. Within the past 216 kyr, 1401 volcanic tie points have been identified. DFO2006 is the chronology for the DF core that strictly follows O2 / N2 age constraints with interpolation using an ice flow model. AICC2012 is the chronology for five cores, including the EDC core, and is characterized by glaciological approaches combining ice flow modelling with various age markers. A precise comparison between the two chronologies was performed. The age differences between them are within 2 kyr, except at Marine Isotope Stage (MIS) 5. DFO2006 gives ages older than AICC2012, with peak values of 4.5 and 3.1 kyr at MIS 5d and MIS 5b, respectively. Accordingly, the ratios of duration (AICC2012 / DFO2006) range between 1.4 at MIS 5e and 0.7 at MIS 5a. When making a comparison with accurately dated speleothem records, the age of DFO2006 agrees well at MIS 5d, while the age of AICC2012 agrees well at MIS 5b, supporting their accuracy at these stages. In addition, we found that glaciological approaches tend to give chronologies with younger ages and with longer durations than age markers suggest at MIS 5d-6. Therefore, we hypothesize that the causes of the DFO2006-AICC2012 age differences at MIS 5 are (i) overestimation in surface mass balance at around MIS 5d-6 in the glaciological approach and (ii) an error in one of the O2 / N2 age constraints by ~ 3 kyr at MIS 5b. Overall, we improved our knowledge of the timing and duration of climatic stages at MIS 5. This new understanding will be incorporated into the production of the next common age scale. Additionally, we found that the deuterium signals of ice, δDice, at DF tends to lead the one at EDC, with the DF lead being more pronounced during cold periods. The lead of DF is by +710 years (maximum) at MIS 5d, -230 years (minimum) at MIS 7a and +60

Dead Sea pollen provides new insights into the paleoenvironment of the southern Levant during MIS 6-5

NASA Astrophysics Data System (ADS)

Chen, Chunzhu; Litt, Thomas

2018-05-01

The paleoclimate of the southern Levant, especially during the last interglacial (LIG), is still under debate. Reliable paleovegetation information for this period, as independent evidence to the paleoenvironment, was still missing. In this study, we present a high-resolution pollen record encompassing 147-89 ka from the Dead Sea deep drilling core 5017-1A. The sediment profile is marked by alternations of laminated marl deposits and thick massive halite, indicating lake-level fluctuations. The pollen record suggests that steppe and desert components predominated in the Dead Sea surroundings during the whole investigated interval. The late penultimate glacial (147.3-130.9 ka) and early last glacial (115.5-89.1 ka) were cool and relatively dry, with sub-humid conditions confined to the mountains that sustained moderate amounts of deciduous oaks. Prior to the LIG optimum, a prevalence of desert components and a concomitant increase in frost-sensitive pistachio trees demonstrate the occurrence of an arid initial warming phase (130.9-124.2 ka). The LIG optimum (124.2 ka-115.5 ka) was initiated by an abrupt grass expansion that was followed by a rapid spread of woodlands in the mountains due to increased moisture availability. The remarkable sclerophyllous expansion points to a strong seasonal moisture deficit. These results contradict previous Dead Sea lake-level investigations that suggested pluvial glacials and a warm, dry LIG in the southern Levant. Prominent discrepancies between vegetation and Dead Sea lake stands are also registered at 128-115 ka, and the potential causes are discussed. In particular, while the pollen spectra mirror increased effective moisture during the LIG optimum, the massive halite deposition is indicative of an extremely low lake level. Given that the climate amelioration triggered the migration of early modern humans to the southern Levant, we speculate that the diverse ecosystems in the region provided great potential for their residence

Downregulation of ribosome biogenesis during early forebrain development

PubMed Central

Chau, Kevin F; Shannon, Morgan L; Fame, Ryann M; Fonseca, Erin; Mullan, Hillary; Johnson, Matthew B; Sendamarai, Anoop K; Springel, Mark W; Laurent, Benoit

2018-01-01

Forebrain precursor cells are dynamic during early brain development, yet the underlying molecular changes remain elusive. We observed major differences in transcriptional signatures of precursor cells from mouse forebrain at embryonic days E8.5 vs. E10.5 (before vs. after neural tube closure). Genes encoding protein biosynthetic machinery were strongly downregulated at E10.5. This was matched by decreases in ribosome biogenesis and protein synthesis, together with age-related changes in proteomic content of the adjacent fluids. Notably, c-MYC expression and mTOR pathway signaling were also decreased at E10.5, providing potential drivers for the effects on ribosome biogenesis and protein synthesis. Interference with c-MYC at E8.5 prematurely decreased ribosome biogenesis, while persistent c-MYC expression in cortical progenitors increased transcription of protein biosynthetic machinery and enhanced ribosome biogenesis, as well as enhanced progenitor proliferation leading to subsequent macrocephaly. These findings indicate large, coordinated changes in molecular machinery of forebrain precursors during early brain development. PMID:29745900

The success of failed Homo sapiens dispersals out of Africa and into Asia.

PubMed

Rabett, Ryan J

2018-02-01

The evidence for an early dispersal of Homo sapiens from Africa into the Levant during Marine Isotope Stage 5 (MIS-5) 126-74 ka (thousand years ago) was characterized for many years as an 'abortive' expansion: a precursor to a sustained dispersal from which all extant human populations can be traced. Recent archaeological and genetic data from both western and eastern parts of Eurasia and from Australia are starting to challenge that interpretation. This Perspective reviews the current evidence for a scenario where the MIS-5 dispersal encompassed a much greater geographic distribution and temporal duration. The implications of this for tracking and understanding early human dispersal in Southeast Asia specifically are considered, and the validity of measuring dispersal success only through genetic continuity into the present is examined.

Fine-grained quartz OSL dating chronology of loess sequence from southern Tajikistan: Implications for climate change in arid central Asia during MIS 2

NASA Astrophysics Data System (ADS)

Wang, Leibin; Jia, Jia; Li, Guoqiang; Li, Zaijun; Wang, Xin; Chen, Fahu

2018-04-01

The desert and semi-desert region of arid central Asia is one of the most important areas of middle-latitude dust emission and deposition in the Northern Hemisphere. Marine isotope stage 2 (MIS 2) was the latest and one of the most representative intervals of dust emission from the region, and it is especially important for research into processes of dust transportation and deposition. Here, we report the results of an optically stimulated luminescence study of the Hoalin section in southern Tajikistan, which was deposited during MIS 2. The fine-grained quartz single aliquot regeneration (SAR) approach was used and its reliability was verified by internal checks. In addition, grain-size analyses, calculated dust accumulation rates (DARs) and mass accumulation rates (MARs) were used to reconstruct the pattern of climate change during MIS 2. The mean DAR for southern Tajikistan during MIS 2 was 0.43 m/ka, and the corresponding average MAR was 673 g/cm2/a for a non-river-terrace site, which is higher than the average MARs estimated for the central and southern Chinese Loess Plateau (CLP). In contrast to previous suggestions, the high dust DARs and MARs during the LGM indicate a 'cold-dry' climatic pattern, rather than a 'cold-humid' pattern. Our results also confirm that the patterns of high dust emission and deposition during the LGM in the mid-latitude arid zone of Asia were synchronous.

Land-sea coupling of early Pleistocene glacial cycles in the southern North Sea exhibit dominant Northern Hemisphere forcing

NASA Astrophysics Data System (ADS)

Donders, Timme H.; van Helmond, Niels A. G. M.; Verreussel, Roel; Munsterman, Dirk; ten Veen, Johan; Speijer, Robert P.; Weijers, Johan W. H.; Sangiorgi, Francesca; Peterse, Francien; Reichart, Gert-Jan; Sinninghe Damsté, Jaap S.; Lourens, Lucas; Kuhlmann, Gesa; Brinkhuis, Henk

2018-03-01

We assess the disputed phase relations between forcing and climatic response in the early Pleistocene with a spliced Gelasian (˜ 2.6-1.8 Ma) multi-proxy record from the southern North Sea basin. The cored sections couple climate evolution on both land and sea during the intensification of Northern Hemisphere glaciation (NHG) in NW Europe, providing the first well-constrained stratigraphic sequence of the classic terrestrial Praetiglian stage. Terrestrial signals were derived from the Eridanos paleoriver, a major fluvial system that contributed a large amount of freshwater to the northeast Atlantic. Due to its latitudinal position, the Eridanos catchment was likely affected by early Pleistocene NHG, leading to intermittent shutdown and reactivation of river flow and sediment transport. Here we apply organic geochemistry, palynology, carbonate isotope geochemistry, and seismostratigraphy to document both vegetation changes in the Eridanos catchment and regional surface water conditions and relate them to early Pleistocene glacial-interglacial cycles and relative sea level changes. Paleomagnetic and palynological data provide a solid integrated timeframe that ties the obliquity cycles, expressed in the borehole geophysical logs, to Marine Isotope Stages (MIS) 103 to 92, independently confirmed by a local benthic oxygen isotope record. Marine and terrestrial palynological and organic geochemical records provide high-resolution reconstructions of relative terrestrial and sea surface temperature (TT and SST), vegetation, relative sea level, and coastal influence.During the prominent cold stages MIS 98 and 96, as well as 94, the record indicates increased non-arboreal vegetation, low SST and TT, and low relative sea level. During the warm stages MIS 99, 97, and 95 we infer increased stratification of the water column together with a higher percentage of arboreal vegetation, high SST, and relative sea level maxima. The early Pleistocene distinct warm-cold alterations are

The medial pterygoid tubercle in the Atapuerca Early and Middle Pleistocene mandibles: evolutionary implications.

PubMed

Bermúdez de Castro, José-María; Quam, Rolf; Martinón-Torres, María; Martínez, Ignacio; Gracia-Téllez, Ana; Arsuaga, Juan Luís; Carbonell, Eudald

2015-01-01

Numerous studies have attempted to identify the presence of uniquely derived (autoapomorphic) Neandertal features. Here, we deal with the medial pterygoid tubercle (MTP), which is usually present on the internal face of the ascending ramus of Neandertal specimens. Our study stems from the identification of a hypertrophied tubercle in ATD6-96, an Early Pleistocene mandible recovered from the TD6 level of the Atapuerca-Gran Dolina site and attributed to Homo antecessor. Our review of the literature and study of numerous original fossil specimens and high quality replicas confirm that the MTP occurs at a high frequency in Neandertals (ca. 89%) and is also present in over half (ca. 55%) of the Middle Pleistocene Sima de los Huesos (SH) hominins. In contrast, it is generally absent or minimally developed in other extinct hominins, but can be found in variable frequencies (MIS 21 or to MIS 25, it seems that a suite of assumed derived Neandertal features appeared in the Early Pleistocene, and they should be interpreted as synapomorphies shared among different taxa. We suggest that H. antecessor, the SH hominins and Neandertals shared a common ancestor in which these features appeared during the Early Pleistocene. The presence of the MTP in taxa other than H. neanderthalensis precludes this feature from being a Neandertal autapomorphy. © 2014 Wiley Periodicals, Inc.

The Inchworm and the Nightingale: On the (Mis)use of Data in Music Teacher Evaluation

ERIC Educational Resources Information Center

Robinson, Mitchell

2015-01-01

The music education profession is faced with two serious problems regarding the (mis)use of data in music teacher evaluation. The first has to do with the quality and kinds of data that music teachers have been forced to use; the second is concerned with how these data are being used in the music teacher evaluation process. The evidence I will use…

CDKL5 alterations lead to early epileptic encephalopathy in both genders.

PubMed

Liang, Jao-Shwann; Shimojima, Keiko; Takayama, Rumiko; Natsume, Jun; Shichiji, Minobu; Hirasawa, Kyoko; Imai, Kaoru; Okanishi, Tohru; Mizuno, Seiji; Okumura, Akihisa; Sugawara, Midori; Ito, Tomoshiro; Ikeda, Hiroko; Takahashi, Yukitoshi; Oguni, Hirokazu; Imai, Katsumi; Osawa, Makiko; Yamamoto, Toshiyuki

2011-10-01

Genetic mutations of the cyclin-dependent kinase-like 5 gene (CDKL5) have been reported in patients with epileptic encephalopathy, which is characterized by intractable seizures and severe-to-profound developmental delay. We investigated the clinical relevance of CDKL5 alterations in both genders. A total of 125 patients with epileptic encephalopathy were examined for genomic copy number aberrations, and 119 patients with no such aberrations were further examined for CDKL5 mutations. Five patients with Rett syndrome, who did not show methyl CpG-binding protein 2 gene (MECP2) mutations, were also examined for CDKL5 mutations. One male and three female patients showed submicroscopic deletions including CDKL5, and two male and six female patients showed CDKL5 nucleotide alterations. Development of early onset seizure was a characteristic clinical feature for the patients with CDKL5 alterations in both genders despite polymorphous seizure types, including myoclonic seizures, tonic seizures, and spasms. Severe developmental delays and mild frontal lobe atrophies revealed by brain magnetic resonance imaging (MRI) were observed in almost all patients, and there was no gender difference in phenotypic features. We observed that 5% of the male patients and 14% of the female patients with epileptic encephalopathy had CDKL5 alterations. These findings indicate that alterations in CDKL5 are associated with early epileptic encephalopathy in both female and male patients. Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.

A girl with early-onset epileptic encephalopathy associated with microdeletion involving CDKL5.

PubMed

Saitsu, Hirotomo; Osaka, Hitoshi; Nishiyama, Kiyomi; Tsurusaki, Yoshinori; Doi, Hiroshi; Miyake, Noriko; Matsumoto, Naomichi

2012-05-01

Recent studies have shown that aberrations of CDKL5 in female patients cause early-onset intractable seizures, severe developmental delay or regression, and Rett syndrome-like features. We report on a Japanese girl with early-onset epileptic encephalopathy, hypotonia, developmental regression, and Rett syndrome-like features. The patient showed generalized tonic seizures, and later, massive myoclonus induced by phone and light stimuli. Brain magnetic resonance imaging showed no structural brain anomalies but cerebral atrophy. Electroencephalogram showed frontal dominant diffuse poly spikes and waves. Through copy number analysis by genomic microarray, we found a microdeletion at Xp22.13. A de novo 137-kb deletion, involving exons 5-21 of CDKL5, RS1, and part of PPEF1 gene, was confirmed by quantitative PCR and breakpoint specific PCR analyses. Our report suggests that the clinical features associated with CDKL5 deletions could be implicated in Japanese patients, and that genetic testing of CDKL5, including both sequencing and deletion analyses, should be considered in girls with early-onset epileptic encephalopathy and RTT-like features. Copyright © 2011 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

Latent profiles of early developmental vulnerabilities in a New South Wales child population at age 5 years.

PubMed

Green, Melissa J; Tzoumakis, Stacy; Laurens, Kristin R; Dean, Kimberlie; Kariuki, Maina; Harris, Felicity; O'Reilly, Nicole; Chilvers, Marilyn; Brinkman, Sally A; Carr, Vaughan J

2018-06-01

Detecting the early emergence of childhood risk for adult mental disorders may lead to interventions for reducing subsequent burden of these disorders. We set out to determine classes of children who may be at risk for later mental disorder on the basis of early patterns of development in a population cohort, and associated exposures gleaned from linked administrative records obtained within the New South Wales Child Development Study. Intergenerational records from government departments of health, education, justice and child protection were linked with the Australian Early Development Census for a state population cohort of 67,353 children approximately 5 years of age. We used binary data from 16 subdomains of the Australian Early Development Census to determine classes of children with shared patterns of Australian Early Development Census-defined vulnerability using latent class analysis. Covariates, which included demographic features (sex, socioeconomic status) and exposure to child maltreatment, parental mental illness, parental criminal offending and perinatal adversities (i.e. birth complications, smoking during pregnancy, low birth weight), were examined hierarchically within latent class analysis models. Four classes were identified, reflecting putative risk states for mental disorders: (1) disrespectful and aggressive/hyperactive behaviour, labelled 'misconduct risk' ( N = 4368; 6.5%); (2) 'pervasive risk' ( N = 2668; 4.0%); (3) 'mild generalised risk' ( N = 7822; 11.6%); and (4) 'no risk' ( N = 52,495; 77.9%). The odds of membership in putative risk groups (relative to the no risk group) were greater among children from backgrounds of child maltreatment, parental history of mental illness, parental history of criminal offending, socioeconomic disadvantage and perinatal adversities, with distinguishable patterns of association for some covariates. Patterns of early childhood developmental vulnerabilities may provide useful indicators

Changes in the Thermohaline Flow due to changes in the WAIS and Astronomical Forcing during the MIS31 Superinterglacial

NASA Astrophysics Data System (ADS)

Justino, F. J.; Lindemann, D.; Kucharski, F.; Wilson, A.; Bromwich, D. H.; Stordal, F.

2017-12-01

The Marine Isotope Stage 31 (MIS31, between 1085 ka and 1055 ka) was characterised by higher extra-tropical air temperatures and a substantial recession of polar glaciers compared to today. Paleoreconstructions and model simulations have increased the understanding of the MIS31 interval, but questions remain regarding the role of the Atlantic and Pacific Oceans in modifying the climate associated with the variations in Earth's orbital parameters. Multi-century coupled climate simulations, with the astronomical configuration of the MIS31 and modified West Antarctic Ice Sheet (WAIS) topography, show an increase in the thermohaline flux and northward oceanic heat transport (OHT) in the Pacific Ocean. These oceanic changes are driven by anomalous atmospheric circulation and increased surface salinity in concert with a stronger meridional overturning circulation (MOC). The intensified northward OHT is responsible for up to 85% of the global OHT anomalies and contributes to the overall reduction in sea-ice in the Northern Hemisphere (NH) due to Earth's astronomical configuration. The relative contributions of the Atlantic Ocean to global OHT and MOC anomalies are minor compared to that of the Pacific. However, sea-ice changes are remarkable, highlighted by decreased (increased) cover in Ross (Weddell) Sea but widespread reductions of sea-ice across the NH. These modeling results have enormous implications for paleoreconstructions of the MIS31 climate that mostly assume overall ice free conditions in the vicinity of the Antarctic continent. Since these reconstructions may depict dominant signals in a particular time interval and locale, they cannot be assumed to geographically represent large-scale domains. Therefore, their ability to reproduce long-term environmental conditions should be considered with care. Finally, it is important to emphasize that understanding past interglacial intervals that are characterized by a depleted WAIS can shed light on the potential

A pollen-based biome reconstruction over the last 3.562 million years in the Far East Russian Arctic - new insights into climate-vegetation relationships at the regional scale

NASA Astrophysics Data System (ADS)

Tarasov, P. E.; Andreev, A. A.; Anderson, P. M.; Lozhkin, A. V.; Leipe, C.; Haltia, E.; Nowaczyk, N. R.; Wennrich, V.; Brigham-Grette, J.; Melles, M.

2013-12-01

The recent and fossil pollen data obtained under the frame of the multi-disciplinary international El'gygytgyn Drilling Project represent a unique archive, which allows the testing of a range of pollen-based reconstruction approaches and the deciphering of changes in the regional vegetation and climate. In the current study we provide details of the biome reconstruction method applied to the late Pliocene and Quaternary pollen records from Lake El'gygytgyn. All terrestrial pollen taxa identified in the spectra from Lake El'gygytgyn were assigned to major vegetation types (biomes), which today occur near the lake and in the broader region of eastern and northern Asia and, thus, could be potentially present in this region during the past. When applied to the pollen spectra from the middle Pleistocene to present, the method suggests (1) a predominance of tundra during the Holocene, (2) a short interval during the marine isotope stage (MIS) 5.5 interglacial distinguished by cold deciduous forest, and (3) long phases of taiga dominance during MIS 31 and, particularly, MIS 11.3. These two latter interglacials seem to be some of the longest and warmest intervals in the study region within the past million years. During the late Pliocene-early Pleistocene interval (i.e., ~3.562-2.200 Ma), there is good correspondence between the millennial-scale vegetation changes documented in the Lake El'gygytgyn record and the alternation of cold and warm marine isotope stages, which reflect changes in the global ice volume and sea level. The biome reconstruction demonstrates changes in the regional vegetation from generally warmer/wetter environments of the earlier (i.e., Pliocene) interval towards colder/drier environments of the Pleistocene. The reconstruction indicates that the taxon-rich cool mixed and cool conifer forest biomes are mostly characteristic of the time prior to MIS G16, whereas the tundra biome becomes a prominent feature starting from MIS G6. These results

An Empirical Examination of the Composition of Vocational Interest in Business Colleges: MIS vs. Other Majors

ERIC Educational Resources Information Center

Downey, James

2011-01-01

Given the diminishing number of Management Information Systems (MIS) majors, an understanding of the factors which influence student choice of major is crucial. It has been noted in many previous studies that interest in a major and career significantly influences the student's choice of college major; indeed, in most studies, it is the strongest…

Examining the Error of Mis-Specifying Nonlinear Confounding Effect with Application on Accelerometer-Measured Physical Activity

ERIC Educational Resources Information Center

Lee, Paul H.

2017-01-01

Purpose: Some confounders are nonlinearly associated with dependent variables, but they are often adjusted using a linear term. The purpose of this study was to examine the error of mis-specifying the nonlinear confounding effect. Methods: We carried out a simulation study to investigate the effect of adjusting for a nonlinear confounder in the…

Study on the electrical degradation of AlGaN/GaN MIS-HEMTs induced by residual stress of SiNx passivation

NASA Astrophysics Data System (ADS)

Bai, Zhiyuan; Du, Jiangfeng; Liu, Yong; Xin, Qi; Liu, Yang; Yu, Qi

2017-07-01

In this paper, we report a new phenomenon in C-V measurement of different gate length MIS-HEMTs, which can be associated with traps character of the AlGaN/GaN interface. The analysis of DC measurement, frequency dependent capacitance-voltage measurements and simulation show that the stress from passivation layer may induce a decrease of drain output current Ids, an increase of on-resistance, serious nonlinearity of transconductance gm, and a new peak of C-V curve. The value of the peak is reduced to zero while the gate length and measure frequency are increasing to 21 μm and 1 MHz, respectively. By using conductance method, the SiNx/GaN interface traps with energy level of EC-0.42 eV to EC-0.45 eV and density of 3.2 × 1012 ∼ 5.0 × 1012 eV-1 cm-2 is obtained after passivation. According to the experimental and simulation results, formation of the acceptor-like traps with concentration of 3 × 1011 cm-2 and energy level of EC-0.37 eV under the gate on AlGaN barrier side of AlGaN/GaN interface is the main reason for the degradation after the passivation. He is currently an Associate Professor with State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Microelectronics and Solid-State Electronics, UESTC. He is the author of over 30 peer-reviewed journal papers and more than 20 conference papers. He has also hold over 20 patents. His research interests include Gallium Nitride based high-voltage power switching devices, microwave and millimeter-wave power devices and integrated technologies. Dr. Yu was a recipient of the prestigious Award of Science and Technology of China

A Combined MIS/DS Course Uses Lecture Capture Technology to "Level the Playing Field" in Student Numeracy

ERIC Educational Resources Information Center

Popovich, Karen

2012-01-01

This paper describes the process taken to develop a quantitative-based and Excel™-driven course that combines "BOTH" Management Information Systems (MIS) and Decision Science (DS) modeling outcomes and lays the foundation for upper level quantitative courses such as operations management, finance and strategic management. In addition,…

Establishing biorientation occurs with precocious separation of the sister kinetochores, but not the arms, in the early spindle of budding yeast.

PubMed

Goshima, G; Yanagida, M

2000-03-17

Sister kinetochores are bioriented toward the spindle poles in higher eukaryotic prometaphase before chromosome segregation. We show that, in budding yeast, the sister kinetochores are separated in the very early spindle, while the sister arms remain associated. Biorientation of the separated kinetochores is achieved already after replication. Mtw1p, a homolog of fission yeast Mis12 required for biorientation, locates at the centromeres in an Ndc10p-dependent manner. Mtw1p and the sequences 1.8 and 3.8 kb from CEN3 and CEN15, respectively, behave like the precociously separated kinetochores, whereas the sequences 23 and 35 kb distant from CEN3 and CEN5 previously used as the centromere markers behave like a part of the arm. Mtw1p and Ndc10p are identically located except for additional spindle localization of Ndc10p. A model explaining small centromeres and early spindle formation in budding yeast is proposed.

Climatic implications of the Quaternary fluvial tufa record in the NE Iberian Peninsula over the last 500 ka

NASA Astrophysics Data System (ADS)

Sancho, Carlos; Arenas, Concha; Vázquez-Urbez, Marta; Pardo, Gonzalo; Lozano, María Victoria; Peña-Monné, José Luis; Hellstrom, John; Ortiz, José Eugenio; Osácar, María Cinta; Auqué, Luis; Torres, Trinidad

2015-11-01

The drainage area of the Iberian Ranges (NE Spain) houses one of the most extensive Quaternary fluvial tufaceous records in Europe. In this study, tufa deposits in the Añamaza, Mesa, Piedra and Ebrón river valleys were mapped, stratigraphically described and chronologically referenced from U/Th disequilibrium series, amino acid racemization and radiocarbon methods. Tufa deposits accumulated in cascades, barrage-cascades and related damming areas developed in stepped fluvial systems. The maximum frequency of tufa deposition was identified at 120 ka (Marine Oxygen Isotope Stage [MIS] 5e), 102 ka (MIS 5c), 85 ka ( MIS 5a) and 7 ka (MIS 1), probably under warmer and wetter conditions than today. Additional phases of tufa deposition appear at 353 ka ( end of MIS 11), 258-180 ka (MIS 7) and 171-154 ka (MIS 6). Although most tufa deposition episodes are clearly correlated with interstadial periods, the occurrence of tufa deposits during the penultimate glaciation (MIS 6) is remarkable, indicating that the onset of this stage was climatically favourable in the Iberian Peninsula. Biostatic conditions and the dynamics of karstic systems regulating tufa deposition seem to be sensitive to the precipitation regime, controlled by shifts in the position of North Atlantic atmospheric belts, and summer insolation, regulated by orbital forcing.

The Y.E.S. Network: An IYPE legacy for engaging future generations of early-career geoscientists

NASA Astrophysics Data System (ADS)

Gonzales, L. M.; Govoni, D.; Micucci, L.; Gaines, S. M.; Venus, J.; Meng, W.

2009-12-01

The Y.E.S. Network, an association of early-career geoscientists who represent professional societies, geoscience companies, and geoscience departments from across the world, was formed as a direct result of the International Year of Planet Earth (IYPE). Currently the Y.E.S. Network has representatives in thirty-five countries from six continents. The goal of the network is to engage early-career representatives from geological associations and institutions, policy-makers, and delegates from administrative bodies to establish a worldwide network of future leaders, policy-makers and geoscientists who will work collaboratively to address the scientific challenges future generations will face. To this end, the Y.E.S. Network, in collaboration with IYPE and with the patronage of UNESCO, organized the first international Y.E.S. Congress which was hosted by the China University of Geosciences in Beijing. The conference focused on scientific and career challenges faced by early-career geoscientists, with a particular emphasis on how the Y.E.S. Network can work collaborative and internationally towards solving these challenges and furthering the IYPE motto of “Earth Sciences for Society”. The conference focused on the ten major themes of the IYPE (e.g. health, climate, groundwater, ocean, soils, deep earth, megacities, hazards, resources, and life) at its poster and oral sessions. Roundtable symposia engaged senior and early-career geoscientists via presentations, panel discussions, and working group sessions where strategies related to scientific challenges (i.e. climate change in the polar regions, natural hazards, natural resource sustainability) and academic and career pathway challenges (i.e. academic-industry linkages, gender parity in the geosciences, geoscience education sustainability, and international licensure issues) were developed. These strategies were then tasked to the Y.E.S. Network for further development and implementation. Future Y.E.S. Network

Early age of e-cigarette use onset mediates the association between impulsivity and e-cigarette use frequency in youth.

PubMed

Bold, Krysten W; Morean, Meghan E; Kong, Grace; Simon, Patricia; Camenga, Deepa R; Cavallo, Dana A; Krishnan-Sarin, Suchitra

2017-12-01

Identifying risk factors for youth e-cigarette use is critical, given high rates of e-cigarette use and unknown health effects of long-term use. The current study examined whether an early age of onset of e-cigarette use mediates the association between impulsivity and e-cigarette frequency. Cross-sectional survey data of e-cigarette users (n=927) were collected from 8 high schools in southeastern Connecticut. The sample was 44.7% female (mean age 16.2 [SD=1.2], mean age of e-cigarette onset 14.7 [SD=1.6]). Two domains of self-reported, trait impulsivity were assessed using the abbreviated Barratt Impulsiveness Scale: impaired self-regulation (e.g., problems with concentration or self-control) and behavioral impulsivity (e.g., doing things without thinking). Mediation was tested with Mplus, and the model included school as a cluster variable and controlled for covariates related to e-cigarette use (i.e., sex, age, race, peer use, and other tobacco products ever tried). The hypothesized mediation was supported for both domains of impulsivity (impaired self-regulation a 1 b=0.09, SE=0.02, 95%CI [0.03-0.14], p=.002; behavioral impulsivity a 2 b=0.07, SE=0.03, 95%CI [.01-.14], p=0.03). Specifically, impaired self-regulation (B=-0.33, SE=0.06, p<0.001) and behavioral impulsivity (B=-0.26, SE=0.11, p=0.02) predicted trying e-cigarettes at an earlier age, and earlier initiation was associated with more days of e-cigarette use in the past month (B=-0.28, SE=0.08, p<0.001). Adolescents who endorse aspects of impulsivity, such as acting without thinking, are at greater risk for more frequent e-cigarette use through an early age of e-cigarette initiation. Further research is needed to evaluate these relationships longitudinally and to develop targeted e-cigarette interventions for impulsive youth. Copyright © 2017 Elsevier B.V. All rights reserved.

Vestibular Activation Differentially Modulates Human Early Visual Cortex and V5/MT Excitability and Response Entropy

PubMed Central

Guzman-Lopez, Jessica; Arshad, Qadeer; Schultz, Simon R; Walsh, Vincent; Yousif, Nada

2013-01-01

Head movement imposes the additional burdens on the visual system of maintaining visual acuity and determining the origin of retinal image motion (i.e., self-motion vs. object-motion). Although maintaining visual acuity during self-motion is effected by minimizing retinal slip via the brainstem vestibular-ocular reflex, higher order visuovestibular mechanisms also contribute. Disambiguating self-motion versus object-motion also invokes higher order mechanisms, and a cortical visuovestibular reciprocal antagonism is propounded. Hence, one prediction is of a vestibular modulation of visual cortical excitability and indirect measures have variously suggested none, focal or global effects of activation or suppression in human visual cortex. Using transcranial magnetic stimulation-induced phosphenes to probe cortical excitability, we observed decreased V5/MT excitability versus increased early visual cortex (EVC) excitability, during vestibular activation. In order to exclude nonspecific effects (e.g., arousal) on cortical excitability, response specificity was assessed using information theory, specifically response entropy. Vestibular activation significantly modulated phosphene response entropy for V5/MT but not EVC, implying a specific vestibular effect on V5/MT responses. This is the first demonstration that vestibular activation modulates human visual cortex excitability. Furthermore, using information theory, not previously used in phosphene response analysis, we could distinguish between a specific vestibular modulation of V5/MT excitability from a nonspecific effect at EVC. PMID:22291031

Interglacial/glacial changes in coccolith-rich deposition in the SW Pacific Ocean: An analogue for a warmer world?

NASA Astrophysics Data System (ADS)

Duncan, Bella; Carter, Lionel; Dunbar, Gavin; Bostock, Helen; Neil, Helen; Scott, George; Hayward, Bruce W.; Sabaa, Ashwaq

2016-09-01

Satellite observations of middle to high latitudes show that modern ocean warming is accompanied by increased frequency and poleward expansion of coccolithophore blooms. However, the outcomes of such events and their causal processes are unclear. In this study, marine sediment cores are used to investigate past coccolithophore production north and south of the Subtropical Front. Calcareous pelagites from subtropical waters off northernmost New Zealand (site P71) and from subantarctic waters on Campbell Plateau (Ocean Drilling Program [ODP] site 1120C) record marked changes in pelagite deposition. At both locations, foraminiferal-rich sediments dominate glacial periods whereas coccolith-rich sediments characterise specific interglacial periods. Sediment grain size has been used to determine relative abundances of coccoliths and foraminifers. Results show coccoliths prevailed around certain Marine Isotope Stage (MIS) transitions, at MIS 7b/a and MIS 2/1 at P71, and at MIS 6/5e at ODP 1120C. Palaeo-environmental proxies suggest that coccolithophore production and deposition at P71 reflect enhanced nutrient availability associated with intense winter mixing in the subtropical Tasman Sea. An increased inflow of that warm, micronutrient-bearing subtropical water in concert with upper ocean thermal stratification in late spring/summer, led to peak phytoplankton production. At ODP 1120C during MIS 6/5e, an increased inflow of subtropical water, warm sea surface temperatures and a thermally stratified upper ocean also favoured coccolithophore production. These palaeo-environmental reconstructions together with model simulations suggest that (i) future subtropical coccolithophore production at P71 is unlikely to reach abundances recorded during MIS 7b/a but (ii) future subantarctic production is likely to dominate sedimentation over Campbell Plateau as modern conditions trend towards those prevalent during MIS 5e.

The role of minimally invasive spine surgery in the management of pyogenic spinal discitis

PubMed Central

Turel, Mazda K; Kerolus, Mena; Deutsch, Harel

2017-01-01

Background: Diagnostic yields for spondylodiscitis from CT guided biopsy is low. In the recent years, minimally invasive surgery (MIS) has shown to have a low morbidity and faster recovery. For spinal infections, MIS surgery may offer an opportunity for early pain control while obtaining a higher diagnostic yield than CT-guided biopsies. The aim of this study was to review our patients who underwent MIS surgery for spinal infection and report outcomes. Methods: A retrospective review of seven patients who underwent MIS decompression and/or discectomy in the setting of discitis, osteomyelitis, spondylodiscitis, and/or an epidural abscess was identified. Patient data including symptoms, visual analog score (VAS), surgical approach, antibiotic regimen, and postoperative outcomes were obtained. Results: Of the 7 patients, 5 patients had lumbar infections and two had thoracic infections. All seven patients improved in VAS immediately after surgery and at discharge. The average VAS improved by 4.4 ± 1.9 points. An organism was obtained in 6 of the 7 (85%) patients by the operative cultures. All patients made an excellent clinical recovery without the need for further spine surgery. All patients who received postoperative imaging on follow-up showed complete resolution or dramatically improved magnetic resonance imaging changes. The follow-up ranged from 2 to 9 months. Conclusions: MIS surgery provides an opportunity for early pain relief in patients with discitis, osteomyelitis, spondylodiscitis, and/or epidural abscess by directly addressing the primary cause of pain. MIS surgery for discitis provides a higher diagnostic yield to direct antibiotic treatment. MIS surgery results in good long-term recovery. PMID:28250635

Late Pleistocene dust dynamics and pedogenesis in Southern Eurasia - Detailed insights from the loess profile Toshan (NE Iran)

NASA Astrophysics Data System (ADS)

Vlaminck, Stefan; Kehl, Martin; Rolf, Christian; Franz, Sven Oliver; Lauer, Tobias; Lehndorff, Eva; Frechen, Manfred; Khormali, Farhad

2018-01-01

In southern Eurasia recurrent phases of aridization, dust source extension and enhanced Aeolian sedimentation alternated with moister intervals, promoting reduced deflation areas and dust accumulation in the context of late Pleistocene climate changes. Weathering and soil forming intensity in this greater region are, hence, mainly governed by fluctuations in the balance between dust supply and moisture availability. Among the hitherto known sections, the Toshan loess-soil sequence (LPS) represents a key site due to the quality of the record and the multitude of available data giving detailed insights into the timing and magnitude of dust accumulation and soil formation of the region. To elucidate these dynamics for much of the past 130.000 years bulk mineralogical and geochemical data are presented supplemented by a high resolution magnetic susceptibility record and by the results of a detailed micromorphological study of loess at Toshan. The last interglacial Luvisol/Phaeozem-like (∼MIS 5e) and the early glacial interstadial steppic palaeosols (∼MIS 5 c and a) are characterized by gradually increasing grain-size and decreasing degrees in decomposition of micaceous and mafic minerals. Pronounced feldspar weathering is detected in the last interglacial and modern soils only, which formed under reduced or absent dust deposition on penultimate and last glacial loess, respectively (postsedimentary). The overall pedosedimentary conditions correspond to large scale trends of increasing drought, dust accumulation and wind strength in southern Eurasia in relation to decreasing moisture availability towards the early Pleniglacial (∼MIS 4), causing soil formation under ongoing dust deposition (synsedimentary). Similar intervals of synsedimentary soil formation are recorded during the interglacial/interstadial-stadial transitions of the early glacial and during pleniglacial (∼MIS 4 to 2) interstadials. The latter are marked by gradual increases in magnetic

Combined vitamin C and vitamin E deficiency worsens early atherosclerosis in apolipoprotein E-deficient mice.

PubMed

Babaev, Vladimir R; Li, Liying; Shah, Sanket; Fazio, Sergio; Linton, MacRae F; May, James M

2010-09-01

To assess the role of combined deficiencies of vitamins C and E on the earliest stages of atherosclerosis (an inflammatory condition associated with oxidative stress), 4 combinations of vitamin supplementation (low C/low E, low C/high E, high C/low E, and high C/high E) were studied in atherosclerosis-prone apolipoprotein E-deficient mice also unable to synthesize their own vitamin C (gulonolactone oxidase(-/-)); and to evaluate the effect of a more severe depletion of vitamin C alone in a second experiment using gulonolactone oxidase(-/-) mice carrying the hemizygous deletion of SVCT2 (the vitamin C transporter). After 8 weeks of a high-fat diet (16% lard and 0.2% cholesterol), atherosclerosis developed in the aortic sinus areas of mice in all diet groups. Each vitamin-deficient diet significantly decreased liver and brain contents of the corresponding vitamin. Combined deficiency of both vitamins increased lipid peroxidation, doubled plaque size, and increased plaque macrophage content by 2- to 3-fold in male mice, although only plaque macrophage content was increased in female mice. A more severe deficiency of vitamin C in gulonolactone oxidase(-/-) mice with defective cellular uptake of vitamin C increased both oxidative stress and atherosclerosis in apolipoprotein E(-/-) mice compared with littermates receiving a diet replete in vitamin C, again most clearly in males. Combined deficiencies of vitamins E and C are required to worsen early atherosclerosis in an apolipoprotein E-deficient mouse model. However, a more severe cellular deficiency of vitamin C alone promotes atherosclerosis when vitamin E is replete.

Hominin teeth from the early Late Pleistocene site of Xujiayao, Northern China.

PubMed

Xing, Song; Martinón-Torres, María; Bermúdez de Castro, Jose María; Wu, Xiujie; Liu, Wu

2015-02-01

It is generally accepted that from the late Middle to the early Late Pleistocene (∼340-90 ka BP), Neanderthals were occupying Europe and Western Asia, whereas anatomically modern humans were present in the African continent. In contrast, the paucity of hominin fossil evidence from East Asia from this period impedes a complete evolutionary picture of the genus Homo, as well as assessment of the possible contribution of or interaction with Asian hominins in the evolution of Homo sapiens and Homo neanderthalensis. Here we present a comparative study of a hominin dental sample recovered from the Xujiayao site, in Northern China, attributed to the early Late Pleistocene (MIS 5 to 4). Our dental study reveals a mosaic of primitive and derived dental features for the Xujiayao hominins that can be summarized as follows: i) they are different from archaic and recent modern humans, ii) they present some features that are common but not exclusive to the Neanderthal lineage, and iii) they retain some primitive conformations classically found in East Asian Early and Middle Pleistocene hominins despite their young geological age. Thus, our study evinces the existence in China of a population of unclear taxonomic status with regard to other contemporary populations such as H. sapiens and H. neanderthalensis. The morphological and metric studies of the Xujiayao teeth expand the variability known for early Late Pleistocene hominin fossils and suggest the possibility that a primitive hominin lineage may have survived late into the Late Pleistocene in China. Copyright © 2014 Wiley Periodicals, Inc.

Development of an e-learning system for teaching endoscopists how to diagnose early gastric cancer: basic principles for improving early detection.

PubMed

Yao, Kenshi; Uedo, Noriya; Muto, Manabu; Ishikawa, Hideki

2017-03-01

We developed an internet e-learning system in order to improve the ability of endoscopists to diagnose gastric cancer at an early stage. The efficacy of this system at expanding knowledge and providing invaluable experience regarding the endoscopic detection of early gastric cancer was demonstrated through an international multicenter randomized controlled trial. However, the contents of the system have not yet been fully described in the literature. Accordingly, we herein introduce the contents and their principles, which comprise three main subjects: technique, knowledge, and experience. Since all the e-learning contents and principles are based on conventional white-light endoscopy alone, which is commonly available throughout the world, they should provide a good reference point for any endoscopist who wishes to devise learning materials and guidelines for improving their own clinical practice.

The End of the Penultimate Interglacial Recorded in Santa Barbara Basin, California

NASA Astrophysics Data System (ADS)

Cannariato, K. G.; Kennett, J. P.

2005-12-01

The marine sediments accumulating in the Santa Barbara Basin, located on the southern California margin, represent a remarkable climate archive. The high sediment accumulation rate, location at the intersection of the cool California Current and warm Countercurrent, and other factors affecting the basin have combined to make the paleoclimate records generated from these sediments highly resolved and very sensitive to global climate change. Because of the effort by Dr. James Kennett over a decade ago to persuade the Ocean Drilling Program to core the basin, the paleoceanographic community has been able to produce some of the most detailed records of Northern Hemisphere climate change over most of the last two glacial-interglacial cycles rivaling those of the Greenland ice cores. Here we present high-resolution planktic and benthic oxygen isotope records from that Santa Barbara Basin core, ODP Site 893, covering the penultimate interglacial and the beginning of the last glacial (MIS 5e to 5d transition). The results indicate that the California Current system exhibited millennial and centennial variability during the penultimate interglacial similar to the early-middle Holocene. The magnitude of this millennial variability increased dramatically and quickly during the transition from MIS 5e to 5d. These millennial-scale oscillations appear to be correlated to those recognized in the North Atlantic region. The implications of this variability will be discussed.

Molecular docking studies of (1E,3E,5E)-1,6-Bis(substituted phenyl)hexa-1,3,5-triene and 1,4-Bis(substituted trans-styryl)benzene analogs as novel tyrosinase inhibitors.

PubMed

Ha, Young Mi; Lee, Hye Jin; Park, Daeui; Jeong, Hyoung Oh; Park, Ji Young; Park, Yun Jung; Lee, Kyung Jin; Lee, Ji Yeon; Moon, Hyung Ryong; Chung, Hae Young

2013-01-01

We simulated the docking of the tertiary structure of mushroom tyrosinase with our compounds. From the structure-tyrosinase inhibitory activity relationship, it is notable that compounds 4, 8 and 11 showed similar or better activity rates than kojic acid which was used as a positive control. Compounds 17, 21, and 23 among benzene analogs that possess the same substituent showed significantly lower tyrosinase inhibitory effects. Therefore, we have confirmed that among the compounds showing better tyrosinase inhibitory effects than kojic acid, the compounds with triene analogs have better tyrosinase inhibitory effect than the compounds with benzene analogs. Docking simulation suggested the mechanism of compounds by several key residues which had possible hydrogen bonding interactions. The pharmacophore model underlined the features of active compounds, 4,4'-((1E,3E,5E)-hexa-1,3,5-triene-1,6-diyl)diphenol, 5,5'-((1E,3E,5E)-hexa-1,3,5-triene-1,6-diyl)bis(2-methoxy-phenol), and 5,5'-((1E,3E,5E)-hexa-1,3,5-triene-1,6-diyl)dibenzene-1,3-diol among triene derivatives which had several hydrogen bond groups on both terminal rings. The soundness of the docking results and the agreement with the pharmacophores suggest that it can be conveniently exploited to design inhibitors with an improved affinity for tyrosinase.

Electrochemical sensor based on molecularly imprinted membranes at platinum nanoparticles-modified electrode for determination of 17β-estradiol.

PubMed

Yuan, Lihua; Zhang, Jun; Zhou, Ping; Chen, Jiaxing; Wang, Ruoyu; Wen, Tingting; Li, Yun; Zhou, Xuemin; Jiang, Huijun

2011-11-15

In this paper, an electrochemical sensor for 17β-estradiol (E2) based on the molecular imprinting polymer (MIP) membranes had been constructed. 6-mercaptonicotinic acid (MNA) and E2 were first assembled on the surface of platinum nanoparticles-modified glassy carbon electrode (PtNPs/GCE) by the formation of Pt-S bonds and hydrogen-bonding interactions, and subsequently the polymer membranes were formed by electropolymerization. Finally, a novel molecularly imprinted sensor (MIS) was obtained after removal of E2. Experimental parameters such as deposition time, scan cycles, pH value and accumulation condition were optimized. Under optimal conditions, the MIS exhibited a large adsorption capacity and high selectivity. A good linearity was obtained in the range of 3.0×10(-8)-5.0×10(-5)molL(-1) (r=0.996) with an estimated detection limit of 1.6×10(-8)molL(-1). MIS had been successfully used to analyze E2 in water samples without complex pretreatment. Meanwhile, the average recoveries were higher than 93.9% with RSD<3.7%. All results above reveal that MIS is an effective electrochemical technique to determine E2 real-time in complicated matrix. Copyright © 2011 Elsevier B.V. All rights reserved.

Combined Vitamin C and Vitamin E Deficiency Worsens Early Atherosclerosis in ApoE-Deficient Mice

PubMed Central

Babaev, Vladimir R.; Li, Liying; Shah, Sanket; Fazio, Sergio; Linton, MacRae F.; May, James M.

2010-01-01

Objective Atherosclerosis is an inflammatory condition associated with oxidative stress, but controversy persists regarding whether antioxidants such as vitamins C and E are preventative. To assess the role of combined deficiencies of vitamins C and E on the earliest stages of atherosclerosis, four combinations of vitamin supplementation (Low C/Low E, Low C/High E, High C/Low E, High C/High E) were studied in atherosclerosis-prone apolipoprotein E (apoE)-deficient mice also unable to synthesize their own vitamin C (gulo−/−). The effect of a more severe depletion of vitamin C alone was evaluated in a second experiment using gulo−/− mice carrying the hemizygous deletion of SVCT2, the vitamin C transporter. Methods and Results After 8 weeks on a high-fat diet (16% lard, 0.2% cholesterol), atherosclerosis developed in the aortic sinus areas of mice in all diet groups. Each vitamin-deficient diet significantly decreased liver and brain contents of the corresponding vitamin. Combined deficiency of both vitamins increased lipid peroxidation, doubled plaque size, and increased plaque macrophage content by 2-3-fold in males, although only plaque macrophage content was increased in females. A more severe deficiency of vitamin C in gulo−/− mice with defective cellular uptake of vitamin C increased both oxidative stress and atherosclerosis in apoE−/− mice compared to littermates on a diet replete in vitamin C, again most clearly in males. Conclusion Combined vitamin E and C deficiencies are required to worsen early atherosclerosis in an apoE-deficient mouse model. However, a more severe cellular deficiency of vitamin C alone promotes atherosclerosis when vitamin E is replete. PMID:20558818

Award for Distinguished Scientific Early Career Contributions to Psychology: Robert E. Ployhart

ERIC Educational Resources Information Center

American Psychologist, 2009

2009-01-01

Robert E. Ployhart, recipient of the Award for Distinguished Scientific Early Career Contributions to Psychology, is cited for innovative work in examining reactions to staffing practices and efforts to enhance the acceptability of recruitment and staffing practices; for exemplary use of applied statistical models in examining multilevel effects…

The effect of mis-specification on mean and selection between the Weibull and lognormal models

NASA Astrophysics Data System (ADS)

Jia, Xiang; Nadarajah, Saralees; Guo, Bo

2018-02-01

The lognormal and Weibull models are commonly used to analyse data. Although selection procedures have been extensively studied, it is possible that the lognormal model could be selected when the true model is Weibull or vice versa. As the mean is important in applications, we focus on the effect of mis-specification on mean. The effect on lognormal mean is first considered if the lognormal sample is wrongly fitted by a Weibull model. The maximum likelihood estimate (MLE) and quasi-MLE (QMLE) of lognormal mean are obtained based on lognormal and Weibull models. Then, the impact is evaluated by computing ratio of biases and ratio of mean squared errors (MSEs) between MLE and QMLE. For completeness, the theoretical results are demonstrated by simulation studies. Next, the effect of the reverse mis-specification on Weibull mean is discussed. It is found that the ratio of biases and the ratio of MSEs are independent of the location and scale parameters of the lognormal and Weibull models. The influence could be ignored if some special conditions hold. Finally, a model selection method is proposed by comparing ratios concerning biases and MSEs. We also present a published data to illustrate the study in this paper.

Dancing to the rhythms of the Pleistocene? Early Middle Paleolithic population dynamics in NW Iberia (Duero Basin and Cantabrian Region)

NASA Astrophysics Data System (ADS)

Sánchez Yustos, Policarpo; Diez Martín, Fernando

2015-08-01

The Northwest of Iberia has yielded one of the most complete European Middle Paleolithic records. Despite this wealth of information, very little is known about population dynamics during this period. For that reason, the main concern of this paper is to provide socio-environmental models that may help explain Early Middle Paleolithic (EMP) population dynamics in NW Iberia, assessing to what extent they were shaped by climate forces. The archaeological record is analyzed on the basis of the heuristics of ecological models, already employed in the European Pleistocene record but never at a regional scale, in order to detect long-term changes in the composition of EMP populations, and the environmental, biological and sociocultural process influencing those changes. According to the models proposed, we have detected a long-term population dynamic between MIS 11 and MIS 6, characterized by low environmental stress, high biological productivity, interaction among populations and sociocultural complexity. Eventually, this population dynamic was broken due to an extreme climate phase in late MIS 6 that had a profound impact on populations and sociocultural structures. As a result, the Upper Pleistocene population of NW Iberia was concentrated in the Cantabrian region. This area became an isolated Neanderthal glacial refugium that hosted a population with different origins and fragile long-term demographic stability.

Interface Si donor control to improve dynamic performance of AlGaN/GaN MIS-HEMTs

NASA Astrophysics Data System (ADS)

Song, Liang; Fu, Kai; Zhang, Zhili; Sun, Shichuang; Li, Weiyi; Yu, Guohao; Hao, Ronghui; Fan, Yaming; Shi, Wenhua; Cai, Yong; Zhang, Baoshun

2017-12-01

In this letter, we have studied the performance of AlGaN/GaN metal-insulator-semiconductor high electron mobility transistors (MIS-HEMTs) with different interface Si donor incorporation which is tuned during the deposition process of LPCVD-SiNx which is adopted as gate dielectric and passivation layer. Current collapse of the MIS-HEMTs without field plate is suppressed more effectively by increasing the SiH2Cl2/NH3 flow ratio and the normalized dynamic on-resistance (RON) is reduced two orders magnitude after off-state VDS stress of 600 V for 10 ms. Through interface characterization, we have found that the interface deep-level traps distribution with high Si donor incorporation by increasing the SiH2Cl2/NH3 flow ratio is lowered. It's indicated that the Si donors are most likely to fill and screen the deep-level traps at the interface resulting in the suppression of slow trapping process and the virtual gate effect. Although the Si donor incorporation brings about the increase of gate leakage current (IGS), no clear degradation of breakdown voltage can be seen by choosing appropriate SiH2Cl2/NH3 flow ratio.

A multiple-approach radiometric age estimate for the Rotoiti and Earthquake Flat eruptions, New Zealand, with implications for the MIS 4/3 boundary

USGS Publications Warehouse

Wilson, C.J.N.; Rhoades, D.A.; Lanphere, M.A.; Calvert, A.T.; Houghton, Bruce F.; Weaver, S.D.; Cole, J.W.

2007-01-01

Pyroclastic fall deposits of the paired Rotoiti and Earthquake Flat eruptions from the Taupo Volcanic Zone (New Zealand) combine to form a widespread isochronous horizon over much of northern New Zealand and the southwest Pacific. This horizon is important for correlating climatic and environmental changes during the Last Glacial period, but has been the subject of numerous disparate age estimates between 35.1??2.8 and 71??6 ka (all errors are 1 s.d.), obtained by a variety of techniques. A potassium-argon (K-Ar) age of 64??4 ka was previously determined on bracketing lavas at Mayor Island volcano, offshore from the Taupo Volcanic Zone. We present a new, more-precise 40Ar/39Ar age determination on a lava flow on Mayor Island, that shortly post-dates the Rotoiti/Earthquake Flat fall deposits, of 58.5??1.1 ka. This value, coupled with existing ages from underlying lavas, yield a new estimate for the age of the combined eruptions of 61.0??1.4 ka, which is consistent with U-Th disequilibrium model-age data for zircons from the Rotoiti deposits. Direct 40Ar/39Ar age determinations of plagioclase and biotite from the Rotoiti and Earthquake Flat eruption products yield variable values between 49.6??2.8 and 125.3??10.0 ka, with the scatter attributed to low radiogenic Ar yields, and/or alteration, and/or inheritance of xenocrystic material with inherited Ar. Rotoiti/Earthquake Flat fall deposits occur in New Zealand in association with palynological indicators of mild climate, attributed to Marine Isotope Stage (MIS) 3 and thus used to suggest an age that is post-59 ka. The natures of the criteria used to define the MIS 4/3 boundary in the Northern and Southern hemispheres, however, imply that the new 61 ka age for the Rotoiti/Earthquake Flat eruption deposits will provide the inverse, namely, a more accurate isochronous marker for correlating diverse changes across the MIS 4/3 boundary in the southwest Pacific. ?? 2007 Elsevier Ltd. All rights reserved.

Tritium-labeled (E,E)-2,5-Bis(4’-hydroxy-3’-carboxystyryl)benzene as a Probe for β-Amyloid Fibrils

PubMed Central

Matveev, Sergey V.; Kwiatkowski, Stefan; Sviripa, Vitaliy M.; Fazio, Robert C.; Watt, David S.; LeVine, Harry

2014-01-01

Accumulation of Aβ in the brains of Alzheimer disease (AD) patients reflects an imbalance between Aβ production and clearance from their brains. Alternative cleavage of amyloid precursor protein (APP) by processing proteases generates soluble APP fragments including the neurotoxic amyloid Aβ40 and Aβ42 peptides that assemble into fibrils and form plaques. Plaque-buildup occurs over an extended time-frame, and the early detection and modulation of plaque formation are areas of active research. Radiolabeled probes for the detection of amyloid plaques and fibrils in living subjects are important for noninvasive evaluation of AD diagnosis, progression, and differentiation of AD from other neurodegenerative diseases and age-related cognitive decline. Tritium-labeled (E,E)-1-[3H]-2,5-bis(4’-hydroxy-3’-carbomethoxystyryl)benzene possesses an improved level of chemical stability relative to a previously reported radioiodinated analog for radiometric quantification of Aβ plaque and tau pathology in brain tissue and in vitro studies with synthetic Aβ and tau fibrils. PMID:25452000

The CDKL5 disorder is an independent clinical entity associated with early-onset encephalopathy.

PubMed

Fehr, Stephanie; Wilson, Meredith; Downs, Jenny; Williams, Simon; Murgia, Alessandra; Sartori, Stefano; Vecchi, Marilena; Ho, Gladys; Polli, Roberta; Psoni, Stavroula; Bao, Xinhua; de Klerk, Nick; Leonard, Helen; Christodoulou, John

2013-03-01

The clinical understanding of the CDKL5 disorder remains limited, with most information being derived from small patient groups seen at individual centres. This study uses a large international data collection to describe the clinical profile of the CDKL5 disorder and compare with Rett syndrome (RTT). Information on individuals with cyclin-dependent kinase-like 5 (CDKL5) mutations (n=86) and females with MECP2 mutations (n=920) was sourced from the InterRett database. Available photographs of CDKL5 patients were examined for dysmorphic features. The proportion of CDKL5 patients meeting the recent Neul criteria for atypical RTT was determined. Logistic regression and time-to-event analyses were used to compare the occurrence of Rett-like features in those with MECP2 and CDKL5 mutations. Most individuals with CDKL5 mutations had severe developmental delay from birth, seizure onset before the age of 3 months and similar non-dysmorphic features. Less than one-quarter met the criteria for early-onset seizure variant RTT. Seizures and sleep disturbances were more common than in those with MECP2 mutations whereas features of regression and spinal curvature were less common. The CDKL5 disorder presents with a distinct clinical profile and a subtle facial, limb and hand phenotype that may assist in differentiation from other early-onset encephalopathies. Although mutations in the CDKL5 gene have been described in association with the early-onset variant of RTT, in our study the majority did not meet these criteria. Therefore, the CDKL5 disorder should be considered separate to RTT, rather than another variant.

Chilean and Southeast Pacific paleoclimate variations during the last glacial cycle: directly correlated pollen and δ18O records from ODP Site 1234

NASA Astrophysics Data System (ADS)

Heusser, Linda; Heusser, Cal; Mix, Alan; McManus, Jerry

2006-12-01

Joint pollen and oxygen isotope data from Ocean Drilling Program Site 1234 in the southeast Pacific provide the first, continuous record of temperate South American vegetation and climate from the last 140 ka. Located at ˜36°S, ˜65 km offshore of Concepcion, Chile, Site 1234 monitors the climatic transition zone between northern semi-arid, summer dry-winter wet climate and southern year-round, rainy, cool temperate climate. Dominance of onshore winds suggests that pollen preserved here reflects transport to the ocean via rivers that drain the region and integrate conditions from the coastal mountains to the Andean foothills. Down-hole changes in diagnostic pollen assemblages from xeric lowland deciduous forest (characterized by grasses, herbs, ferns, and trees such as deciduous beech, Nothofagus obliqua), mesic Valdivian Evergreen Forest (including conifers such as the endangered Prumnopitys andina), and Subantarctic Evergreen Rainforest (comprised primarily of southern beech, N. dombeyi) reveal large rapid shifts that likely reflect latitudinal movements in atmospheric circulation and storm tracks associated with the southern westerly winds. During glacial intervals (MIS 2-4, and 6), rainforests and parkland dominated by Nothofagus moved northward into the region. At the MIS 6/5e transition, coeval with the rapid shift to lower isotopic values, rainforest vegetation was rapidly replaced by xeric plant communities associated with Mediterranean-type climate. An increased prominence of halophytic vegetation suggests that MIS 5e was more arid and possibly warmer than MIS 1. Although rainforest pollen rises again at the end of MIS 5e, lowland deciduous forest pollen persists through MIS 5d and 5c, into MIS 5b. Substantial millennial-scale variations occur in both interglacial and glacial regimes, attesting to the sensitivity of the southern westerly belt to climate change. Comparison of the cool, mesic N. dombeyi rainforest assemblage from Site 1234 with δ18O in