Sample records for early modern london

  1. From Apprentice to Master: Social Disciplining and Surgical Education in Early Modern London, 1570-1640

    ERIC Educational Resources Information Center

    Chamberland, Celeste

    2013-01-01

    Due to its ascendancy as the administrative and commercial center of early modern England, London experienced sustained growth in the latter half of the sixteenth century, as waves of rural immigrants sought to enhance their material conditions by tapping into the city's bustling occupational and civic networks. The resultant crowded urban…

  2. MINDING THEIR OWN BUSINESS: MARRIED WOMEN AND CREDIT IN EARLY EIGHTEENTH-CENTURY LONDON.

    PubMed

    Shepard, Alexandra

    2015-12-01

    Taking a micro-historical approach, this paper explores the business activities of Elizabeth Carter and Elizabeth Hatchett, two married women who operated together as pawnbrokers in London in the early decades of the eighteenth century. Based on a protracted inheritance dispute through which their extensive dealings come to light, the discussion assesses married women's lending and investment strategies in a burgeoning metropolitan economy; the networks through which women lenders operated; and the extent to which wives could sidestep the legal conventions of 'coverture' which restricted their ownership of moveable property. It is argued that the moneylending and asset management activities of women like Carter and Hatchett were an important part of married women's work that did not simply consolidate neighbourhood ties but that placed them at the heart of the early modern economy.

  3. Beck Exportation: London and Sydney

    NASA Astrophysics Data System (ADS)

    Cartwright, William; Field, Kenneth

    2018-05-01

    Henry (Harry) Beck's schematic map of the London Underground is the foundation for most `modern' representations of metropolitan rail systems. From its introduction in the 1930s, it has been the image of the London underground rail transportation system, and, indeed, the image of London itself. Following the launch of the schematic map in 1933 Londoners adopted his representation of the underground as the favoured transportation navigation tool, but also as a physical affirmation that they were citizens of a modern city, a city of electricity and the avant-garde. The London Underground map, as well as being the physical image of the underground rail system, became the signature of the modern city itself. It projected order, systematic transportation and commuter convenience. The map reinforced the general belief that a modern transportation system was at the very heart of what made a city a city. Building upon the success of the map, Beck, and the London Passenger Transport Board, explored how this `take' on the representation of an urban transportation system might be exported to other European, and Antipodean rail networks. This paper provides a dialogue on how Beck's concept for the `metromap' was offered as an alternative navigational diagram to the, then new, Sydney underground system. It then outlines the results of an investigation about how this `Exportation' of Beck's design resulted in the 1939 Sydney metromap that was a clone of the London Underground map.

  4. London, England

    NASA Image and Video Library

    2003-01-18

    For almost 2,000 years, the River Thames has served as the life force of London, capital of the United Kingdom and one of the world's most famous cities. In AD 43 the Romans established the trading settlement of Londinium at a favorable crossing point on the river. The Romans remained until the 5th century, when the city came under Saxon control. The early 17th century saw enormous growth, but the deadly plague of 1664 and 1665 ravaged the population, and in the following year the Great Fire, which burned for four days, destroyed most of the city. A public transportation system and other city services in the early 19th century eased many of the increasing urban problems of the burgeoning capital of the wealthy British Empire. After coping with the devastating effects of bombing during World War II and the gradual dismantling of the empire, London today thrives as a vital modern metropolis. London is one of 100 cities being studied using ASTER data to map and monitor urban use patterns and growth. This image was acquired on October 12, 2001 by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet. http://photojournal.jpl.nasa.gov/catalog/PIA04301

  5. Patterns of early transmission of pandemic influenza in London – link with deprivation

    PubMed Central

    Balasegaram, Sooria; Ogilvie, Flora; Glasswell, Amy; Anderson, Charlotte; Cleary, Vivien; Turbitt, Deborah; McCloskey, Brian

    2012-01-01

    Please cite this paper as: Balasegaram et al. (2012) Patterns of early transmission of pandemic influenza in London – link with deprivation. Influenza and Other Respiratory Viruses 6(3), e35–e41. Background  During the early containment phase in England from April to June 2009, the national strategy for H1N1 pandemic influenza involved case investigation and treatment, and tracing and prophylaxis of contacts. Objective  To describe the relationship between early transmission of H1N1 pandemic influenza in London and age and socio‐economic status. Methods  Epidemiological data on cases of pandemic flu in London reported to the London Flu Response Centre were analysed to determine patterns of transmission. Results  There were 3487 reported cases (2202 confirmed, 1272 presumed and 14 probable) from 20 April to 28 June 2009, during the ‘containment’ period. The highest report rate of 206 per 100 000 (95% CI 195–218) was seen in primary school–age children (5−11 years) followed by 129 (95% CI 119–139) in secondary school–age children (12–18 years). Reports of cases were initially concentrated in affluent areas but overall showed a clear trend with deprivation and risk ratio of 2·32 (95% CI 1·94–2·78) between the most deprived and the least deprived. Conclusion  Early transmissions were highest amongst school‐aged children but linked with socio‐economic deprivation across all age groups. PMID:22236079

  6. Prophecy, patriarchy, and violence in the early modern household: the revelations of Anne Wentworth.

    PubMed

    Johnston, Warren

    2009-10-01

    In 1676 the apostate Baptist prophet Anne Wentworth (1629/30-1693?) published "A True Account of Anne Wentworths Being Cruelly, Unjustly, and Unchristianly Dealt with by Some of Those People called Anabaptists," the first in a series of pamphlets that would continue to the end of the decade. Orignially a member of a London Baptist church, Wentworth left the congregation and eventually her own home after her husband used physical force to stop her writing and prophesying. Yet Wentworth persisted in her "revelations." These prophecies increasingly focused on her response to those who were trying to stop her efforts, especially within her own household. This article examines Wentworth's writings as an effort by an early modern woman, using arguments of spiritual agency, to assert ideas about proper gender roles and household responsibilities to denounce her husband and rebut those who criticized and attempted to suppress her.

  7. Making Early Modern Medicine: Reproducing Swedish Bitters.

    PubMed

    Ahnfelt, Nils-Otto; Fors, Hjalmar

    2016-05-01

    Historians of science and medicine have rarely applied themselves to reproducing the experiments and practices of medicine and pharmacy. This paper delineates our efforts to reproduce "Swedish Bitters," an early modern composite medicine in wide European use from the 1730s to the present. In its original formulation, it was made from seven medicinal simples: aloe, rhubarb, saffron, myrrh, gentian, zedoary and agarikon. These were mixed in alcohol together with some theriac, a composite medicine of classical origin. The paper delineates the compositional history of Swedish Bitters and the medical rationale underlying its composition. It also describes how we go about to reproduce the medicine in a laboratory using early modern pharmaceutical methods, and analyse it using contemporary methods of pharmaceutical chemistry. Our aim is twofold: first, to show how reproducing medicines may provide a path towards a deeper understanding of the role of sensual and practical knowledge in the wider context of early modern medical culture; and second, how it may yield interesting results from the point of view of contemporary pharmaceutical science.

  8. Archives and the Boundaries of Early Modern Science.

    PubMed

    Popper, Nicholas

    2016-03-01

    This contribution argues that the study of early modern archives suggests a new agenda for historians of early modern science. While in recent years historians of science have begun to direct increased attention toward the collections amassed by figures and institutions traditionally portrayed as proto-scientific, archives proliferated across early modern Europe, emerging as powerful tools for creating knowledge in politics, history, and law as well as natural philosophy, botany, and more. The essay investigates the methods of production, collection, organization, and manipulation used by English statesmen and Crown officers such as Keeper of the State Papers Thomas Wilson and Secretary of State Joseph Williamson to govern their disorderly collections. Their methods, it is shown, were shared with contemporaries seeking to generate and manage other troves of evidence and in fact reflect a complex ecosystem of imitation and exchange across fields of inquiry. These commonalities suggest that historians of science should look beyond the ancestors of modern scientific disciplines to examine how practices of producing knowledge emerged and migrated throughout cultures of learning in Europe and beyond. Creating such a map of knowledge production and exchange, the essay concludes, would provide a renewed and expansive ambition for the field.

  9. London's historic pea-soupers''

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Urbinato, D.

    Americans may think smog was invented in Los Angeles. Not so. In fact, a Londoner coined the term smog'' in 1905 to describe the city's insidious combination of natural fog and coal smoke. By then, the phenomenon was part of London history, and dirty, acrid smoke-filled pea-soupers'' were as familiar to Londoners as Big Ben and Westminster Abby. Smog in London predates Shakespeare by four centuries. Until the 12th century, most Londoners burned wood for fuel. But as the city grew and the forests shrank, wood became scarce and increasingly expensive. Large deposits of sea-coal'' off the northeast coast providedmore » a cheap alternative. Soon, Londoners were burning the soft, bituminous coal to heat their homes and fuel their factories. Sea-coal was plentiful, but it didn't burn efficiently. A lot of its energy was spent making smoke, not heat. Coal smoke drifting through thousands of London chimneys combined with clean natural fog to make smog. If the weather conditions were right, it would last for days. Early on, no one had the scientific tools to correlate smog with adverse health effects, but complaints about the smoky air as an annoyance date back to at least 1272, when King Edward I, on the urging of important noblemen and clerics, banned the burning of sea-coal. Anyone caught burning or selling the stuff was to be tortured or executed. The first offender caught was summarily put to death. This deterred nobody. Of necessity, citizens continued to burn sea-coal in violation of the law, which required the burning of wood few could afford.« less

  10. London, England

    NASA Technical Reports Server (NTRS)

    2003-01-01

    For almost 2,000 years, the River Thames has served as the life force of London, capital of the United Kingdom and one of the world's most famous cities. In AD 43 the Romans established the trading settlement of Londinium at a favorable crossing point on the river. The Romans remained until the 5th century, when the city came under Saxon control. The early 17th century saw enormous growth, but the deadly plague of 1664 and 1665 ravaged the population, and in the following year the Great Fire, which burned for four days, destroyed most of the city. A public transportation system and other city services in the early 19th century eased many of the increasing urban problems of the burgeoning capital of the wealthy British Empire. After coping with the devastating effects of bombing during World War II and the gradual dismantling of the empire, London today thrives as a vital modern metropolis. London is one of 100 cities being studied using ASTER data to map and monitor urban use patterns and growth.

    This image was acquired on October 12, 2001 by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet.

    ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products.

    The broad spectral coverage and high spectral resolution of ASTER will provide scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats

  11. Art engagement and mental health: experiences of service users of a community-based arts programme at Tate Modern, London.

    PubMed

    McKeown, Eamonn; Weir, Hannele; Berridge, Emma-Jane; Ellis, Liz; Kyratsis, Yiannis

    2016-01-01

    To examine the experiences of mental health service users who took part in an arts-based programme at Tate Modern, a major London art gallery. Exploratory qualitative design. Data were collected using in-depth semi-structured interviews with 10 mental health service users who had taken part in a community-based programme at Tate Modern. Additionally, six art educators from Tate Modern were interviewed. Concepts that emerged from the text were identified using thematic analysis. All participants valued the gallery-based programme. The three overarching thematic areas were: the symbolic and physical context in which the programme workshops were located; the relational and social context of the programme workshops; and reflections on the relationship between the arts-based programme and subsequent mental health. Art galleries are increasingly seen to function as vehicles for popular education with mental health service users. This study adds to the growing body of evidence related to how mental health service users experience and reflect on arts-related programmes targeted at them. This study indicates that emphasis on how users experience gallery-based programmes may contribute to a more nuanced understanding of the relationship between art and mental health. Copyright © 2015 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  12. The women of the family? Speculations around early modern British physicians.

    PubMed

    Pelling, M

    1995-12-01

    In the extensively explored areas of professionalization, domestic ideology, and the relationships between women and medicine, the debate on the British case has given little consideration to issues of identity arising for the male medical practitioner as a result of family life. For the early modern period, these issues can be seen as among a broad-ranging set of problems posed by the female gender connotations of the medical role. Such problems were most pronounced for the élite physicians who sought membership of the London College of Physicians. Their attitudes and dilemmas are important because of their influence, over the long term, on the criteria for professionalization. Using biographical data, a contrast can be shown between the dynastic ideals of physicians, which stressed the male line, and the high incidence among such physicians of celibacy, childlessness, and small families. Families of origin of physicians, on the other hand, tended to be large. Assumptions about the role of women in medical care, especially in clerical and gentry families, entail a recognition of the possible influence of female relatives on the vocations of male physicians. Given the low status of women's work, physicians developed ambivalences which affected the construction of their identities, their families, and the passing on of their skills.

  13. Art in wartime: The First Wounded, London Hospital, August 1914.

    PubMed

    Park, M P; Park, R H R

    2011-06-01

    John Lavery's The First Wounded, London Hospital, August 1914 records a memorable event in the First World War. This painting and the archives of the Royal London Hospital provide a fascinating insight into the nursing and medical care of these early war casualties.

  14. Preterit Loss in Early Modern Nuremberg

    ERIC Educational Resources Information Center

    Bagwell, Angela Catania

    2013-01-01

    This study investigates "Prateritumschwund," one of the most salient developments in the Upper German dialect area during the Early Modern period. Drawing on a wide range of text types originating in Nuremberg and its surrounding areas from the 13th to the 17th centuries, this study tests various hypotheses put forward as alleged causes…

  15. Early modern mathematical instruments.

    PubMed

    Bennett, Jim

    2011-12-01

    In considering the appropriate use of the terms "science" and "scientific instrument," tracing the history of "mathematical instruments" in the early modern period is offered as an illuminating alternative to the historian's natural instinct to follow the guiding lights of originality and innovation, even if the trail transgresses contemporary boundaries. The mathematical instrument was a well-defined category, shared across the academic, artisanal, and commercial aspects of instrumentation, and its narrative from the sixteenth to the eighteenth century was largely independent from other classes of device, in a period when a "scientific" instrument was unheard of.

  16. Early Period of Modern Architecture in Turkey - A Case Study of Eskisehir

    NASA Astrophysics Data System (ADS)

    Karasozen, Rana

    2017-10-01

    Modern architecture in the Western World bore fruit at the beginning of the 20th Century in consequence of the process of modernity and seeking of the proper architecture for it. It was formed firstly towards the end of the 1920s. The main reason of this nonsynchronous development was the inadequacy of enlightenment and industrial revolution during the Ottoman Empire and the lack of formation of an intellectual infrastructure which provides the basis of modernity. However, the Ottoman Westernization occurring in the 19th century constituted the foundations of the Republic modernity founded in 1923. The earliest modern architectural designs in Turkey were first practised by European architects after the foundation of the Republic and internalised and practised extensively by the native architects afterwards. The early modern architecture of Turkey, named as “1930s Modernism”, continued until the beginning of the World War II. This period was formed in between the periods of first and second nationalist architecture movements. The early modern architecture period of Turkey was a period which high-quality designs were made. It was practised and internalised not only in big cities such as Ankara and in Istanbul, but also in the medium and small cities of the country. This situation was not just about a formal exception but about the internalisation of modernity by the society. Eskisehir is one of the most important pioneering cities of the Republic period in terms of industrial and educational developments. The earliest modern buildings were built as the public buildings by the state and non-citizen architects in the inadequate conditions of the country in terms of economy and professional people. The earliest modern houses of the city designed by these architects were the prototypes for the later practices which offered the citizens a new lifestyle. The modern houses were the symbols of prestige and status for the owners and the dwellers. The features of early

  17. Ancient gene flow from early modern humans into Eastern Neanderthals.

    PubMed

    Kuhlwilm, Martin; Gronau, Ilan; Hubisz, Melissa J; de Filippo, Cesare; Prado-Martinez, Javier; Kircher, Martin; Fu, Qiaomei; Burbano, Hernán A; Lalueza-Fox, Carles; de la Rasilla, Marco; Rosas, Antonio; Rudan, Pavao; Brajkovic, Dejana; Kucan, Željko; Gušic, Ivan; Marques-Bonet, Tomas; Andrés, Aida M; Viola, Bence; Pääbo, Svante; Meyer, Matthias; Siepel, Adam; Castellano, Sergi

    2016-02-25

    It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together with the sequences of chromosome 21 of two Neanderthals from Spain and Croatia. We find that a population that diverged early from other modern humans in Africa contributed genetically to the ancestors of Neanderthals from the Altai Mountains roughly 100,000 years ago. By contrast, we do not detect such a genetic contribution in the Denisovan or the two European Neanderthals. We conclude that in addition to later interbreeding events, the ancestors of Neanderthals from the Altai Mountains and early modern humans met and interbred, possibly in the Near East, many thousands of years earlier than previously thought.

  18. Print Culture, Moral Panic, and the Administration of the Law: The London Crime Wave of 1744.

    PubMed

    Ward, Richard

    2012-01-01

    In the second half of 1744, a moral panic about street robberies gripped London. The article argues that moral panics of the modern law and order variety are evident as early as the mid-eighteenth century. As with other historical panics, printed media and public opinion played a key role in driving the panic of 1744. Various genres of crime literature presented street robbery as an especially threatening problem. In the wake of this alarm, crime and justice came in for extensive public discussion in the press, and several changes were made to the administration of the law in the metropolis. The expansion of print culture and new opportunities for voicing public opinion in the eighteenth century provided the essential foundations for the genesis of the modern form of moral panic, a phenomenon which continues to have a significant impact upon criminal justice policy today.

  19. Erotic Love and the Development of Proto-Capitalist Ideology in Early Modern Comedy

    ERIC Educational Resources Information Center

    Damsen, Silver

    2009-01-01

    My dissertation, "Erotic Love and the Development of Proto-Capitalist Ideology in Early Modern Comedy" demonstrates how increased crown authority, and an expanded market combine with the mixed agency of the romantic comedy daughter to further encourage early modern economic growth. The triumph of rebelling daughter over blocking father has…

  20. The 'other' London effect: the diversification of London's suburban grammar schools and the rise of hyper-selective elite state schools.

    PubMed

    Gamsu, Sol

    2018-03-30

    This paper examines the rise of a new elite of 'super-state' schools in London, revealing a growing divide within the state sector which problematizes claims that the capital is a 'hotspot' for social mobility (Social Mobility Commission ). Although recent research has revealed a 'London effect' in which students in the capital on Free School Meals outperform their peers in other regions (Greaves, Macmillan and Sibieta ), inequalities between London's schools in access to elite universities have been overlooked. Drawing on a case study of a suburban London grammar school, 'King Henry's School', I show how ethnic-minority suburbanization has combined with an institutional strategy to compete with elite private schools. Strategies of selection have been mobilized alongside elements of elite 'gentlemanly' educational culture in order to reposition the school within the hierarchy of London's schools. The result is a hyper-selective school which provides a conduit to elite universities for upwardly mobile British-Asian students. I show that this strategy has strong parallels with the school's attempts in the early twentieth century to compete with London's fee-paying 'public' schools. The continuing symbolic value of 'traditional' forms of elite educational culture to a school seeking to reposition itself within the field reflects deep structural patterns of inequality in English education. To understand how apparent improvements in social mobility can sit alongside deepening inequalities between state schools, there is a need for a historical sociological approach that takes account of long-term processes of institutional change (Savage ; Inglis ). © London School of Economics and Political Science 2018.

  1. Trading secrets: Jews and the early modern quest for clandestine knowledge.

    PubMed

    Jütte, Daniel

    2012-12-01

    This essay explores the significance and function of secrecy and secret sciences in Jewish-Christian relations and in Jewish culture in the early modern period. It shows how the trade in clandestine knowledge and the practice of secret sciences became a complex, sometimes hazardous space for contact between Jews and Christians. By examining this trade, the essay clarifies the role of secrecy in the early modern marketplace of knowledge. The attribution of secretiveness to Jews was a widespread topos in early modern European thought. However, relatively little is known about the implications of such beliefs in science or in daily life. The essay pays special attention to the fact that trade in secret knowledge frequently offered Jews a path to the center of power, especially at court. Furthermore, it becomes clear that the practice of secret sciences, the trade in clandestine knowledge, and a mercantile agenda were often inextricably interwoven. Special attention is paid to the Italian-Jewish alchemist, engineer, and entrepreneur Abramo Colorni (ca. 1544-1599), whose career illustrates the opportunities provided by the marketplace of secrets at that time. Much scholarly (and less scholarly) attention has been devoted to whether and what Jews "contributed" to what is commonly called the "Scientific Revolution." This essay argues that the question is misdirected and that, instead, we should pay more attention to the distinctive opportunities offered by the early modern economy of secrecy.

  2. Early modern human diversity suggests subdivided population structure and a complex out-of-Africa scenario

    PubMed Central

    Gunz, Philipp; Bookstein, Fred L.; Mitteroecker, Philipp; Stadlmayr, Andrea; Seidler, Horst; Weber, Gerhard W.

    2009-01-01

    The interpretation of genetic evidence regarding modern human origins depends, among other things, on assessments of the structure and the variation of ancient populations. Because we lack genetic data from the time when the first anatomically modern humans appeared, between 200,000 and 60,000 years ago, instead we exploit the phenotype of neurocranial geometry to compare the variation in early modern human fossils with that in other groups of fossil Homo and recent modern humans. Variation is assessed as the mean-squared Procrustes distance from the group average shape in a representation based on several hundred neurocranial landmarks and semilandmarks. We find that the early modern group has more shape variation than any other group in our sample, which covers 1.8 million years, and that they are morphologically similar to recent modern humans of diverse geographically dispersed populations but not to archaic groups. Of the currently competing models of modern human origins, some are inconsistent with these findings. Rather than a single out-of-Africa dispersal scenario, we suggest that early modern humans were already divided into different populations in Pleistocene Africa, after which there followed a complex migration pattern. Our conclusions bear implications for the inference of ancient human demography from genetic models and emphasize the importance of focusing research on those early modern humans, in particular, in Africa. PMID:19307568

  3. Print Culture, Moral Panic, and the Administration of the Law: The London Crime Wave of 1744 1

    PubMed Central

    Ward, Richard

    2018-01-01

    In the second half of 1744, a moral panic about street robberies gripped London. The article argues that moral panics of the modern law and order variety are evident as early as the mid-eighteenth century. As with other historical panics, printed media and public opinion played a key role in driving the panic of 1744. Various genres of crime literature presented street robbery as an especially threatening problem. In the wake of this alarm, crime and justice came in for extensive public discussion in the press, and several changes were made to the administration of the law in the metropolis. The expansion of print culture and new opportunities for voicing public opinion in the eighteenth century provided the essential foundations for the genesis of the modern form of moral panic, a phenomenon which continues to have a significant impact upon criminal justice policy today. PMID:29780277

  4. Ali, Cunich: Halley's Churches: Halley and the London Queen Anne Churches

    NASA Astrophysics Data System (ADS)

    Ali, Jason R.; Cunich, Peter

    2005-04-01

    Edmond Halley's enormous contribution to science has received much attention. New research adds an intriguing chapter to his story and concerns his hitherto unexplored association with the baroque architectural visionary Nicholas Hawksmoor, and some important Temple-inspired churches that were built in London in the early 1700s. We argue that Christchurch Spitalfields and St Anne's Limehouse, which were both started in the summer of 1714, were aligned exactly eastwards using ``corrected'' magnetic-compass bearings and that Halley influenced or aided Hawksmoor. By this time the men had probably known each other for 30 years and had recently worked together on the Clarendon Building in Oxford. Despite there being more than 1500 years of Chinese and about 500 years of Western compass technology at the time, these probably represent the first constructions planned using a modern-day ``scientific'' technique. The research also throws light on Halley's contended religious position.

  5. [Four cholera epidemics in nineteenth-century London].

    PubMed

    Tynkkynen, K

    1995-01-01

    Asiatic cholera originated in India and spread to Europe in the early years of the nineteenth-century. In Britain the first cases were diagnosed late in 1831. The epidemic, reached London in February 1832. The authorities were poorly prepared for the invasion of a new epidemic and the doctors disagreed bitterly on the measures to be taken. There was little co-operation between the authorities, and the fact that the urban poor mistrusted the medical profession did not improve the situation. All this resulted in several cholera riots. These riots were not, however, as violent as those in several other cities in Europe. The 1832-33 cholera epidemic claimed 4,000 to 7,000 victims in London. It seems probable that several isolated cases of cholera occurred in London in 1852. It was not, however, until September 1853 that it was officially announced by the British authorities that a cholera epidemic was claiming victims not only in London but also in other parts of the country. During this epidemic numerous Londoners lodged complaints against nuisances in the metropolis. Yet, in most cases, the fines imposed on offenders were rather slight, since the authorities were extremely reluctant to interfere with anyone's trade or business. It was during this epidemic that John Snow, a London doctor, succeeded in tracing the epidemic to a single water pump on Broad Street in the Golden Square area. Snow did not, however, succeed in convincing the majority of his colleagues regarding the erroneous nature of the miasma theory during the epidemic of 1853/54, which cost the lives of some 12,000 people in the city area....

  6. The second modern condition? Compressed modernity as internalized reflexive cosmopolitization.

    PubMed

    Kyung-Sup, Chang

    2010-09-01

    Compressed modernity is a civilizational condition in which economic, political, social and/or cultural changes occur in an extremely condensed manner in respect to both time and space, and in which the dynamic coexistence of mutually disparate historical and social elements leads to the construction and reconstruction of a highly complex and fluid social system. During what Beck considers the second modern stage of humanity, every society reflexively internalizes cosmopolitanized risks. Societies (or their civilizational conditions) are thereby being internalized into each other, making compressed modernity a universal feature of contemporary societies. This paper theoretically discusses compressed modernity as nationally ramified from reflexive cosmopolitization, and, then, comparatively illustrates varying instances of compressed modernity in advanced capitalist societies, un(der)developed capitalist societies, and system transition societies. In lieu of a conclusion, I point out the declining status of national societies as the dominant unit of (compressed) modernity and the interactive acceleration of compressed modernity among different levels of human life ranging from individuals to the global community. © London School of Economics and Political Science 2010.

  7. Measuring the Effectiveness of Knowledge Creation as a Means of Facilitating Evidence-Informed Practice in Early Years Settings in One London Borough

    ERIC Educational Resources Information Center

    Brown, Chris; Rogers, Sue

    2014-01-01

    This paper examines our use of knowledge-creation activity as a way of developing evidence-informed practice among a learning community of 36 early years practitioners in one London borough. It also seeks to illustrate how we approached the idea of measuring evidence use and our engagement with, and adapted use of, two separate measurement scales:…

  8. Great Originals of Modern Physics

    ERIC Educational Resources Information Center

    Decker, Fred W.

    1972-01-01

    European travel can provide an intimate view of the implements and locales of great discoveries in physics for the knowledgeable traveler. The four museums at Cambridge, London, Remscheid-Lennep, and Munich display a full range of discovery apparatus in modern physics as outlined here. (Author/TS)

  9. 111. Shaws Cove Bridge. New London, New London Co., CT. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    111. Shaws Cove Bridge. New London, New London Co., CT. Sec. 4209, MP 122.65. - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  10. 110. Shaws Cove Bridge. New London, New London Co., CT. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    110. Shaws Cove Bridge. New London, New London Co., CT. Sec. 4209, MP 122.65. - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  11. Earliest evidence of modern human life history in North African early Homo sapiens.

    PubMed

    Smith, Tanya M; Tafforeau, Paul; Reid, Donald J; Grün, Rainer; Eggins, Stephen; Boutakiout, Mohamed; Hublin, Jean-Jacques

    2007-04-10

    Recent developmental studies demonstrate that early fossil hominins possessed shorter growth periods than living humans, implying disparate life histories. Analyses of incremental features in teeth provide an accurate means of assessing the age at death of developing dentitions, facilitating direct comparisons with fossil and modern humans. It is currently unknown when and where the prolonged modern human developmental condition originated. Here, an application of x-ray synchrotron microtomography reveals that an early Homo sapiens juvenile from Morocco dated at 160,000 years before present displays an equivalent degree of tooth development to modern European children at the same age. Crown formation times in the juvenile's macrodont dentition are higher than modern human mean values, whereas root development is accelerated relative to modern humans but is less than living apes and some fossil hominins. The juvenile from Jebel Irhoud is currently the oldest-known member of Homo with a developmental pattern (degree of eruption, developmental stage, and crown formation time) that is more similar to modern H. sapiens than to earlier members of Homo. This study also underscores the continuing importance of North Africa for understanding the origins of human anatomical and behavioral modernity. Corresponding biological and cultural changes may have appeared relatively late in the course of human evolution.

  12. Malocclusion in Early Anatomically Modern Human: A Reflection on the Etiology of Modern Dental Misalignment

    PubMed Central

    Sarig, Rachel; Slon, Viviane; Abbas, Janan; May, Hila; Shpack, Nir; Vardimon, Alexander Dan; Hershkovitz, Israel

    2013-01-01

    Malocclusions are common in modern populations. Yet, as the study of occlusion requires an almost intact dentition in both the maxilla and mandible, searching for the ultimate cause of malocclusion is a challenge: relatively little ancient material is available for research on occlusal states. The Qafzeh 9 skull is unique, as its preserved dentition allowed us to investigate the presence and manifestations of malocclusion. The aim of this study was thus to examine the occlusal condition in the Qafzeh 9 specimen in light of modern knowledge regarding the etiology of malocclusion. We revealed a pathologic occlusion in the Qafzeh 9 skull that probably originated in the early developmental stage of the dentition, and was aggravated by forces applied by mastication. When arch continuity is interrupted due to misalignment of teeth as in this case, force transmission is not equal on both sides, causing intra-arch outcomes such as mesialization of the teeth, midline deviation, rotations and the aggravation of crowding. All are evident in the Qafzeh 9 skull: the midline deviates to the left; the incisors rotate mesio-buccally; the left segment is constricted; the left first molar is buccally positioned and the left premolars palatally tilted. The inter-arch evaluation revealed anterior cross bite with functional shift that might affect force transmission and bite force. In conclusion, the findings of the current study suggest that malocclusion of developmental origin was already present in early anatomically modern humans (AMH) (the present case being the oldest known case, dated to ca. 100,000 years); that there is no basis to the notion that early AMH had a better adjustment between teeth and jaw size; and that jaw-teeth size discrepancy could be found in prehistoric populations and is not a recent phenomenon. PMID:24278319

  13. Parish apprenticeship and the old poor law in London.

    PubMed

    Levene, Alysa

    2010-01-01

    This article offers an examination of the patterns and motivations behind parish apprenticeship in late eighteenth- and early nineteenth-century London. It stresses continuity in outlook from parish officials binding children, which involved placements in both the traditional and industrializing sectors of the economy. Evidence on the ages, employment types, and locations of 3,285 pauper apprentices bound from different parts of London between 1767 and 1833 indicates a variety of local patterns. The analysis reveals a pattern of youthful age at binding, a range of employment experiences, and parish-specific links to particular trades and manufactures.

  14. Zilsel's Thesis, Maritime Culture, and Iberian Science in Early Modern Europe.

    PubMed

    Leitão, Henrique; Sánchez, Antonio

    2017-01-01

    Zilsel's thesis on the artisanal origins of modern science remains one of the most original proposals about the emergence of scientific modernity. We propose to inspect the scientific developments in Iberia in the early modern period using Zilsel's ideas as a guideline. Our purpose is to show that his ideas illuminate the situation in Iberia but also that the Iberian case is a remarkable illustration of Zilsel's thesis. Furthermore, we argue that Zilsel's thesis is essentially a sociological explanation that cannot be applied to isolated cases; its use implies global events that involve extended societies over large periods of time.

  15. Ancient genomes link early farmers from Atapuerca in Spain to modern-day Basques.

    PubMed

    Günther, Torsten; Valdiosera, Cristina; Malmström, Helena; Ureña, Irene; Rodriguez-Varela, Ricardo; Sverrisdóttir, Óddny Osk; Daskalaki, Evangelia A; Skoglund, Pontus; Naidoo, Thijessen; Svensson, Emma M; Bermúdez de Castro, José María; Carbonell, Eudald; Dunn, Michael; Storå, Jan; Iriarte, Eneko; Arsuaga, Juan Luis; Carretero, José-Miguel; Götherström, Anders; Jakobsson, Mattias

    2015-09-22

    The consequences of the Neolithic transition in Europe--one of the most important cultural changes in human prehistory--is a subject of great interest. However, its effect on prehistoric and modern-day people in Iberia, the westernmost frontier of the European continent, remains unresolved. We present, to our knowledge, the first genome-wide sequence data from eight human remains, dated to between 5,500 and 3,500 years before present, excavated in the El Portalón cave at Sierra de Atapuerca, Spain. We show that these individuals emerged from the same ancestral gene pool as early farmers in other parts of Europe, suggesting that migration was the dominant mode of transferring farming practices throughout western Eurasia. In contrast to central and northern early European farmers, the Chalcolithic El Portalón individuals additionally mixed with local southwestern hunter-gatherers. The proportion of hunter-gatherer-related admixture into early farmers also increased over the course of two millennia. The Chalcolithic El Portalón individuals showed greatest genetic affinity to modern-day Basques, who have long been considered linguistic and genetic isolates linked to the Mesolithic whereas all other European early farmers show greater genetic similarity to modern-day Sardinians. These genetic links suggest that Basques and their language may be linked with the spread of agriculture during the Neolithic. Furthermore, all modern-day Iberian groups except the Basques display distinct admixture with Caucasus/Central Asian and North African groups, possibly related to historical migration events. The El Portalón genomes uncover important pieces of the demographic history of Iberia and Europe and reveal how prehistoric groups relate to modern-day people.

  16. European early modern humans and the fate of the Neandertals

    PubMed Central

    Trinkaus, Erik

    2007-01-01

    A consideration of the morphological aspects of the earliest modern humans in Europe (more than ≈33,000 B.P.) and the subsequent Gravettian human remains indicates that they possess an anatomical pattern congruent with the autapomorphic (derived) morphology of the earliest (Middle Paleolithic) African modern humans. However, they exhibit a variable suite of features that are either distinctive Neandertal traits and/or plesiomorphic (ancestral) aspects that had been lost among the African Middle Paleolithic modern humans. These features include aspects of neurocranial shape, basicranial external morphology, mandibular ramal and symphyseal form, dental morphology and size, and anteroposterior dental proportions, as well as aspects of the clavicles, scapulae, metacarpals, and appendicular proportions. The ubiquitous and variable presence of these morphological features in the European earlier modern human samples can only be parsimoniously explained as a product of modest levels of assimilation of Neandertals into early modern human populations as the latter dispersed across Europe. This interpretation is in agreement with current analyses of recent and past human molecular data. PMID:17452632

  17. Fritz London

    NASA Astrophysics Data System (ADS)

    Gavroglu, Kostas

    2005-11-01

    Preface; Acknowledgements; Part I. From Philosophy to Physics: The years that left nothing unaffected; 1. The appeal of ideas; 2. Goëthe as a scientist; 3. How absolute is our knowledge?; 4. How do we come to know things?; 5. London's teachers in philosophy; 6. Husserl's teachings; 7. Expectations of things to come; 8. The thesis in philosophy; 9. Tolman's principle of similitude; 10. The necessary clarifications; 11. Work on quantum theory; 12. Transformation theory; 13. Unsuccessful attempts at unification; Part II. The Years in Berlin and the Beginnings of Quantum Chemistry: The mysterious bond; 14. London in Zürich; 15. Binding forces; 16. The Pauli principle; 17. Reactions to the Heitler-London paper; 18. Polyelectronic molecules and the application of group theory to problems of chemical valence; 19. Chemists as physicists?; 20. London's first contacts in Berlin; 21. Marriage; 22. Job offers; 23. Intermolecular forces; 24. The book which could not be written; 25. Leningrad and Rome; 26. Difficulties with group theory; 27. Linus Pauling's resonance structures; 28. Robert Mulliken's molecular orbitals; Part III. Oxford and Superconductivity: The rise of the Nazis; 29. Going to Oxford; 30. Lindemann, Simon and Heinz London; 31. Electricity in the very cold; 32. The end of old certainties; 33. The thermodynamic treatment; 34. The theory of Fritz and Heinz London; 35. Initial reactions by von Laue; 36. The discussion at the Royal Society; 37. Termination of the ICI fellowship; Part IV. Paris and Superfluidity: The Front Populaire; 38. The article in Nature 1937 and 'Nouvelle Conception'; 39. Laue again; 40. The structure of solid helium; 41. The peculiar properties of helium; 42. Bose-Einstein condensation; 43. The note in Nature; 44. The two-fluid model; 45. The trip to Jerusalem; 46. Leaving again; 47. The observer in quantum mechanics; Part V. United States and the Typing up of Loose Ends: Duke University, North Carolina; 48. The Soviet Union, Kapitza and

  18. Measuring the Effectiveness of Knowledge Creation Activity as a Means to Facilitate Evidence-Informed Practice: A Study of Early Years Settings in Camden, London

    ERIC Educational Resources Information Center

    Brown, Chris; Rogers, Sue

    2015-01-01

    This paper has two key aims. First, it examines the authors' attempts to use knowledge creation activity as a way of developing evidence-informed practice amongst a learning community of 36 early years practitioners in Camden, London. Second, it illustrates how the authors approached the idea of measuring evidence use and our engagement with two…

  19. Early Modern Humans and Morphological Variation in Southeast Asia: Fossil Evidence from Tam Pa Ling, Laos

    PubMed Central

    Demeter, Fabrice; Shackelford, Laura; Westaway, Kira; Duringer, Philippe; Bacon, Anne-Marie; Ponche, Jean-Luc; Wu, Xiujie; Sayavongkhamdy, Thongsa; Zhao, Jian-Xin; Barnes, Lani; Boyon, Marc; Sichanthongtip, Phonephanh; Sénégas, Frank; Karpoff, Anne-Marie; Patole-Edoumba, Elise; Coppens, Yves; Braga, José

    2015-01-01

    Little is known about the timing of modern human emergence and occupation in Eastern Eurasia. However a rapid migration out of Africa into Southeast Asia by at least 60 ka is supported by archaeological, paleogenetic and paleoanthropological data. Recent discoveries in Laos, a modern human cranium (TPL1) from Tam Pa Ling‘s cave, provided the first evidence for the presence of early modern humans in mainland Southeast Asia by 63-46 ka. In the current study, a complete human mandible representing a second individual, TPL 2, is described using discrete traits and geometric morphometrics with an emphasis on determining its population affinity. The TPL2 mandible has a chin and other discrete traits consistent with early modern humans, but it retains a robust lateral corpus and internal corporal morphology typical of archaic humans across the Old World. The mosaic morphology of TPL2 and the fully modern human morphology of TPL1 suggest that a large range of morphological variation was present in early modern human populations residing in the eastern Eurasia by MIS 3. PMID:25849125

  20. Assembling the dodo in early modern natural history.

    PubMed

    Lawrence, Natalie

    2015-09-01

    This paper explores the assimilation of the flightless dodo into early modern natural history. The dodo was first described by Dutch sailors landing on Mauritius in 1598, and became extinct in the 1680s or 1690s. Despite this brief period of encounter, the bird was a popular subject in natural-history works and a range of other genres. The dodo will be used here as a counterexample to the historical narratives of taxonomic crisis and abrupt shifts in natural history caused by exotic creatures coming to Europe. Though this bird had a bizarre form, early modern naturalists integrated the dodo and other flightless birds through several levels of conceptual categorization, including the geographical, morphological and symbolic. Naturalists such as Charles L'Ecluse produced a set of typical descriptive tropes that helped make up the European dodo. These long-lived images were used for a variety of symbolic purposes, demonstrated by the depiction of the Dutch East India enterprise in Willem Piso's 1658 publication. The case of the dodo shows that, far from there being a dramatic shift away from emblematics in the seventeenth century, the implicit symbolic roles attributed to exotic beasts by naturalists constructing them from scant information and specimens remained integral to natural history.

  1. Sex differences of dental pathology in early modern samurai and commoners at Kokura in Japan.

    PubMed

    Oyamada, Joichi; Kitagawa, Yoshikazu; Hara, Masahito; Sakamoto, Junya; Matsushita, Takayuki; Tsurumoto, Toshiyuki; Manabe, Yoshitaka

    2017-07-01

    So-called "Ohaguro", teeth blackening, in the married females was a general custom regardless of class in the early modern period. As a result, Ohaguro was thought to have enhanced the acid resistance of tooth substance and tightened gingiva and prevented tooth morbidity due to periodontal disease. For investigation into the influence of Ohaguro, the skeletal remains of early modern samurai and commoners at Kokura were examined for differences in the dental pathology based on sex. Though females from archeological sites have significantly more carious teeth and antemortem tooth loss (AMTL) than males in the previous studies, the prevalence of caries and AMTL in males was higher than in females among the early modern samurai and commoners in Kokura. The efficacies of Ohaguro may influence the good dental health of females. On the other hand, as females were considered inferior to males under the feudal system in Japan, males, including children, might tend to consume more nutritious foods compared to females. However, those foods are certainly not better with regard to dental health, since those foods are more highly cariogenic. These factors may have caused higher caries and AMTL prevalence among males compared to females in early modern Kokura.

  2. The early Upper Paleolithic human skeleton from the Abrigo do Lagar Velho (Portugal) and modern human emergence in Iberia

    PubMed Central

    Duarte, Cidália; Maurício, João; Pettitt, Paul B.; Souto, Pedro; Trinkaus, Erik; van der Plicht, Hans; Zilhão, João

    1999-01-01

    The discovery of an early Upper Paleolithic human burial at the Abrigo do Lagar Velho, Portugal, has provided evidence of early modern humans from southern Iberia. The remains, the largely complete skeleton of a ≈4-year-old child buried with pierced shell and red ochre, is dated to ca. 24,500 years B.P. The cranium, mandible, dentition, and postcrania present a mosaic of European early modern human and Neandertal features. The temporal bone has an intermediate-sized juxtamastoid eminence. The mandibular mentum osseum and the dental size and proportions, supported by mandibular ramal features, radial tuberosity orientation, and diaphyseal curvature, as well as the pubic proportions align the skeleton with early modern humans. Body proportions, reflected in femorotibial lengths and diaphyseal robusticity plus tibial condylar displacement, as well as mandibular symphyseal retreat and thoracohumeral muscle insertions, align the skeleton with the Neandertals. This morphological mosaic indicates admixture between regional Neandertals and early modern humans dispersing into southern Iberia. It establishes the complexities of the Late Pleistocene emergence of modern humans and refutes strict replacement models of modern human origins. PMID:10377462

  3. Wealth, health and frailty in industrial-era London.

    PubMed

    DeWitte, Sharon N; Hughes-Morey, Gail; Bekvalac, Jelena; Karsten, Jordan

    2016-05-01

    Socioeconomic status is a powerful predictor of mortality in living populations, as status affects exposure or access to a variety of factors that impact health and survival, such as diet, healthcare, infectious disease and pollution. This study examines the effect of socioeconomic status on mortality and survival in London during a period spanning the early 18th through mid-19th centuries. During this period, London experienced rapid industrialization and heightened class distinctions. This study examines whether low-socioeconomic status was associated with reduced survival at a time when the distinctions between social strata were peaking. The samples for this study are drawn from three skeletal assemblages in London that represent lower and higher social strata. The upper socioeconomic status sample (n = 394) is from Chelsea Old Church and St Bride's Fleet Street (crypt assemblage). The low socioeconomic status sample (n = 474) is from St. Bride's Lower Churchyard (also known as St Bride's Farringdon Street). The effect of status on mortality and survival is assessed using hazard analysis and Kaplan-Meier analysis. The results reveal elevated mortality and reduced survival for lower socioeconomic status children, but no strong effect of status on adult mortality or survival. These results might indicate strong selective mortality operating during childhood or the effects of migration in the industrial-era population of London.

  4. Parish apprenticeship and the old poor law in London1

    PubMed Central

    Levene, Alysa

    2010-01-01

    This article offers an examination of the patterns and motivations behind parish apprenticeship in late eighteenth- and early nineteenth-century London. It stresses continuity in outlook from parish officials binding children, which involved placements in both the traditional and industrializing sectors of the economy. Evidence on the ages, employment types, and locations of 3,285 pauper apprentices bound from different parts of London between 1767 and 1833 indicates a variety of local patterns. The analysis reveals a pattern of youthful age at binding, a range of employment experiences, and parish-specific links to particular trades and manufactures. PMID:20939134

  5. The varying influence of socioeconomic deprivation on breast cancer screening uptake in London.

    PubMed

    Jack, Ruth H; Robson, Tony; Davies, Elizabeth A

    2016-06-01

    We assessed the relationship between screening uptake and socioeconomic deprivation for London women aged 50-52 invited to their first routine screening appointment between 2006 and 2009. We examined uptake for London overall and within six screening areas, using deprivation quintile, based on post code of residence. After adjustment for age, area and ethnicity, overall uptake decreased with increasing deprivation (adjusted odds ratio (OR) = 0.95, P < 0.001). However, in two screening areas with lower uptake, women living in deprived areas had higher uptake than women from affluent areas. These potential inequalities in early diagnosis across London require further investigation. © Crown copyright 2015.

  6. 'Holding the line': a qualitative study of the role of evidence in early phase decision-making in the reconfiguration of stroke services in London.

    PubMed

    Fraser, Alec; Baeza, Juan I; Boaz, Annette

    2017-06-09

    Health service reconfigurations are of international interest but remain poorly understood. This article focuses on the use of evidence by senior managerial decision-makers involved in the reconfiguration of stroke services in London 2008-2012. Recent work comparing stroke service reconfiguration in London and Manchester emphasises the ability of senior managerial decision-makers in London to 'hold the line' in the crucial early phases of the stroke reconfiguration programme. In this article, we explore in detail how these decision-makers 'held the line' and ask what the broader power implications of doing so are for the interaction between evidence, health policy and system redesign. The research combined semi-structured interviews (n = 20) and documentary analysis of historically relevant policy papers and contemporary stroke reconfiguration documentation published by NHS London and other interested parties (n = 125). We applied a critical interpretive and reflexive approach to the analysis of the data. We identified two forms of power which senior managerial decision-makers drew upon in order to 'hold the line'. Firstly, discursive power, which through an emphasis on evidence, better patient outcomes, professional support and clinical credibility alongside a tightly managed consultation process, helped to set an agenda that was broadly receptive to the overall decision to change stroke services in the capital in a radical way. Secondly, once the essential parameters of the decision to change services had been agreed, senior managerial decision-makers 'held the line' through hierarchical New Public Management style power to minimise the traditional pressures to de-radicalise the reconfiguration through 'top down' decision-making. We problematise the concept of 'holding the line' and explore the power implications of such managerial approaches in the early phases of health service reconfiguration. We highlight the importance of evidence for senior managerial

  7. Pan-London tuberculosis services: a service evaluation

    PubMed Central

    2012-01-01

    Background London has the largest proportion of tuberculosis (TB) cases of any western European capital, with almost half of new cases drug-resistant. Prevalence varies considerably between and within boroughs with research suggesting inadequate control of TB transmission in London. Economic pressures may exacerbate the already considerable challenges for service organisation and delivery within this context. This paper presents selected findings from an evaluation of London’s TB services’ organisation, delivery, professional workforce and skill mix, intended to support development of a strategic framework for a pan-London TB service. These may also interest health service professionals and managers in TB services in the UK, other European cities and countries and in services currently delivered by multiple providers operating independently. Methods Objectives were: 1) To establish how London’s TB services are structured and delivered in relation to leadership, management, organisation and delivery, coordination, staffing and support; 2) To identify tools/models for calculating skill mix as a basis for identifying skill mix requirements in delivering TB services across London; 3) To inform a strategic framework for the delivery of a pan-London TB service, which may be applicable to other European cities. The multi-method service audit evaluation comprised documentary analysis, semi-structured interviews with TB service users (n = 10), lead TB health professionals and managers (n = 13) representing London’s five sectors and focus groups with TB nurses (n = 8) and non-London network professionals (n = 2). Results Findings showed TB services to be mainly hospital-based, with fewer community-based services. Documentary analysis and professionals’ interviews suggested difficulties with early access to services, low suspicion index amongst some GPs and restricted referral routes. Interviews indicated lack of managed accommodation for

  8. Ancient gene flow from early modern humans into Eastern Neanderthals

    PubMed Central

    Kuhlwilm, Martin; Gronau, Ilan; Hubisz, Melissa J.; de Filippo, Cesare; Prado-Martinez, Javier; Kircher, Martin; Fu, Qiaomei; Burbano, Hernán A.; Lalueza-Fox, Carles; de la Rasilla, Marco; Rosas, Antonio; Rudan, Pavao; Brajkovic, Dejana; Kucan, Željko; Gušic, Ivan; Marques-Bonet, Tomas; Andrés, Aida M.; Viola, Bence; Pääbo, Svante; Meyer, Matthias; Siepel, Adam; Castellano, Sergi

    2016-01-01

    It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000–65,000 years ago. Here, we analyze the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together with the sequences of chromosome 21 of two Neanderthals from Spain and Croatia. We find that a population that diverged early from other modern humans in Africa contributed genetically to the ancestors of Neanderthals from the Altai Mountains roughly 100,000 years ago. By contrast, we do not detect such a genetic contribution in the Denisovan or the two European Neanderthals. We conclude that in addition to later interbreeding events, the ancestors of Neanderthals from the Altai Mountains and of modern humans met and interbred, possibly in the Near East, many thousands of years earlier than previously reported. PMID:26886800

  9. Early modern human lithic technology from Jerimalai, East Timor.

    PubMed

    Marwick, Ben; Clarkson, Chris; O'Connor, Sue; Collins, Sophie

    2016-12-01

    Jerimalai is a rock shelter in East Timor with cultural remains dated to 42,000 years ago, making it one of the oldest known sites of modern human activity in island Southeast Asia. It has special global significance for its record of early pelagic fishing and ancient shell fish hooks. It is also of regional significance for its early occupation and comparatively large assemblage of Pleistocene stone artefacts. Three major findings arise from our study of the stone artefacts. First, there is little change in lithic technology over the 42,000 year sequence, with the most noticeable change being the addition of new artefact types and raw materials in the mid-Holocene. Second, the assemblage is dominated by small chert cores and implements rather than pebble tools and choppers, a pattern we argue pattern, we argue, that is common in island SE Asian sites as opposed to mainland SE Asian sites. Third, the Jerimalai assemblage bears a striking resemblance to the assemblage from Liang Bua, argued by the Liang Bua excavation team to be associated with Homo floresiensis. We argue that the near proximity of these two islands along the Indonesian island chain (c.100 km apart), the long antiquity of modern human occupation in the region (as documented at Jerimalai), and the strong resemblance of distinctive flake stone technologies seen at both sites, raises the intriguing possibility that both the Liang Bua and Jerimalai assemblages were created by modern humans. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. "Old Poems Have Heart": Teenage Students Reading Early Modern Poetry

    ERIC Educational Resources Information Center

    Naylor, Amanda

    2013-01-01

    The proposals for the revised National Curriculum in English suggest limiting the pre-twentieth century poetry that GCSE pupils read to "representative Romantic poetry" (Department for Education [DFE], 2013, p. 4). This paper argues that poetry of the early modern period is challenging and enriching study for adolescent pupils and that…

  11. The Corporeality of Learning: Confucian Education in Early Modern Japan

    ERIC Educational Resources Information Center

    Tsujimoto, Masashi

    2016-01-01

    The intellectual foundation of early modern Japan was provided by Confucianism--a system of knowledge set forth in Chinese classical writings. In order to gain access to this knowledge, the Japanese applied reading markers to modify the original Chinese to fit the peculiarities of Japanese grammar and pronunciation. Confucian education started by…

  12. All that glitters: fool's gold in the early-modern era.

    PubMed

    Roos, Anna Marie

    2008-12-01

    Natural philosophers of the early-modern period perceived fool's gold or iron pyrites as a substance required for the formation of metals, and chemists such as Johann Glauber speculated the vitriol produced from pyrites was the source of the legendary philosopher's stone. The sulphurous exhalations of fool's gold were also thought by members of the early Royal Society to be the basis of a variety of meteorological, geological and medical effects, including the production of thunder, lightning, earthquakes and volcanoes, fossilisation and petrifaction, as well as the principal cause of bladder and gallstones.

  13. The Commerce of Utility: Teaching Mathematical Geography in Early Modern England

    ERIC Educational Resources Information Center

    Cormack, Lesley B.

    2006-01-01

    The teaching and learning of geographical and mathematical knowledge in early modern England was a complex interaction among scholars, practitioners, merchants, and gentry. Each group had different values and goals associated with geographical knowledge and therefore different educational venues and different topics to be investigated. This paper…

  14. Seeing you through London 2012: eye care at the Paralympics.

    PubMed

    Wilson, Clare M; Thomson, W David; D'Ath, Penny J

    2013-09-01

    The provision of eye care services for competitors and support teams is integral to the modern Olympic Games. The eye clinic for the London 2012 Paralympic Games employed a multidisciplinary team of eye care professionals using state-of-the-art instrumentation to provide the highest level of eye care. The detailed organisation of the eye care clinic at London 2012 is described in a companion paper which summarises the eye care clinic during the London 2012 Olympic Games. These two reports will aid in planning eye care clinics at future Games. This paper summarises the organisation of the eye clinic and provides outline audit data relating to eye conditions encountered during the Paralympic Games. A total of 870 patients representing 102 countries attended the eye clinic. 274 (31.5%) were competitors; the remainder were trainers and support staff. No serious ocular injuries resulted from competitor injury in the field of play during the Paralympic Games, although seven patients were referred urgently to hospital eye services for conditions including orbital cellulitis, retinal detachment, exudative macular degeneration, corneal ulcer, Stevens-Johnson syndrome and macular oedema. A total of 749 spectacles, 14 pairs of contact lenses and 7 low vision aids were dispensed. By combining excellent facilities and equipment with a multidisciplinary team of eye care professionals, we feel we provided the highest level of eye care, providing a legacy for future Games.

  15. A Fruitful Exchange/Conflict: Engineers and Mathematicians in Early Modern Italy

    ERIC Educational Resources Information Center

    Maffioli, Cesare S.

    2013-01-01

    Exchanges of learning and controversies between engineers and mathematicians were important factors in the development of early modern science. This theme is discussed by focusing, first, on architectural and mathematical dynamism in mid 16th-century Milan. While some engineers-architects referred to Euclid and Vitruvius for improving their…

  16. Are Londoners Prepared for an Emergency? A Longitudinal Study Following the London Bombings

    PubMed Central

    Rubin, James; Amlôt, Richard; Simpson, John; Wessely, Simon

    2008-01-01

    The UK government sees increasing individual preparedness as a priority, but the level of preparedness of people in the UK for a large-scale emergency is not known. The London bombings of July 7, 2005, affected many Londoners and may have altered their sense of vulnerability to a future terrorist attack. We used a longitudinal study design to assess individual preparedness within the same sample of Londoners at 2 points in time: immediately after the bombings (T1) and 7 to 8 months later (T2). A demographically representative sample of 1,010 Londoners participated in a phone interview at T1. Subsequently, at T2, 574 of the same people participated in a follow-up phone interview. At T1 51% of Londoners had made 4 or more relevant emergency plans; 48% had gathered 4 or more relevant supplies in case of emergency. There was evidence of increased preparedness at T2, by which time 90% had made 4 or more emergency plans. Ethnicity, low social status, and having felt a sense of threat during the bombings predicted increased preparedness between T1 and T2. Women in general, and women of low social status in particular, perceived themselves to be unprepared in the event of a future terrorist attack. In summary, Londoners show moderate levels of emergency preparedness, which increased following the London bombings. Although we cannot know whether this association is causal, the prospective nature of the study increases the likelihood that it is. However, preparedness is still patchy, and there are important demographic associations with levels of preparedness and perception of vulnerability. These findings have implications for future development of individual and community emergency preparedness policy. PMID:19117430

  17. Trading Zones in Early Modern Europe.

    PubMed

    Long, Pamela O

    2015-12-01

    This essay adopts the concept of trading zones first developed for the history of science by Peter Galison and redefines it for the early modern period. The term "trading zones" is used to mean arenas in which substantive and reciprocal communication occurred between individuals who were artisanally trained and learned (university-trained) individuals. Such trading zones proliferated in the sixteenth century. They tended to arise in certain kinds of places and not in others, but their existence must be determined empirically. The author's work on trading zones differs from the ideas of Edgar Zilsel, who emphasized the influence of artisans on the scientific revolution. In contrast, in this essay, the mutual influence of artisans and the learned on each other is stressed, and translation is used as a modality that was important to communication within trading zones.

  18. Religion in the National Historical Narrative of the Early Modern Times in Contemporary Ukrainian Schooling

    ERIC Educational Resources Information Center

    Shevchenko, Tetiana

    2015-01-01

    This article deals with religious discourse in modern history school textbooks in Ukraine that cover early modern times in Ukrainian history. It analyzes the place of religious discourse within national discourse, the correlation between local Ukrainian religious and more general discourse, and the representation of the relationships between…

  19. ‘Herbals she peruseth’: reading medicine in early modern England

    PubMed Central

    Leong, Elaine

    2014-01-01

    In 1631, Richard Brathwaite penned a conduct manual for ‘English Gentlewomen’. In Brathwaite's mind, the ideal English gentlewoman was not only chaste, modest and honourable but also an avid reader. In fact, Brathwaite specifically recommends English gentlewomen to first peruse herbals and then to deepen their medical knowledge via conference. Centred on the manuscript notebooks of two late seventeenth-century women, Margaret Boscawen (d. 1688) and Elizabeth Freke (1642–1714), this article explores women and ‘medical reading’ in early modern England. It first demonstrates that whilst both women consulted herbals by contemporary authors such as John Gerard and Nicholas Culpeper, their modes of reading could not be more different. Where Freke ruminated, digested and abstracted from Gerard's large tome, Boscawen made practical lists from Culpeper's The English Physitian. Secondly, the article shows that both supplemented their herbal reading with a range of other vernacular medical texts including printed medical recipe books, contemporary pharmacopoeia and surgical handbooks. Early modern English women's medical reading, I argue, was nuanced, sophisticated and diverse. Furthermore, I contend that well-informed readers like Boscawen and Freke made smart medical consumers and formidable negotiators in their medical encounters. PMID:25821333

  20. Knowledge Creation as an Approach to Facilitating Evidence Informed Practice: Examining Ways to Measure the Success of Using This Method with Early Years Practitioners in Camden (London)

    ERIC Educational Resources Information Center

    Brown, Chris; Rogers, Sue

    2015-01-01

    This paper has three key aims. First it examines the authors' attempts to use knowledge creation activity as a way of developing evidence informed practice amongst a learning community of 36 early years practitioners in the London Borough of Camden. Second, it seeks to illustrate how the authors approached the idea of measuring evidence use and…

  1. Casebooks in Early Modern England:

    PubMed Central

    Kassell, Lauren

    2014-01-01

    summary Casebooks are the richest sources that we have for encounters between early modern medical practitioners and their patients. This article compares astrological and medical records across two centuries, focused on England, and charts developments in the ways in which practitioners kept records and reflected on their practices. Astrologers had a long history of working from particular moments, stellar configurations, and events to general rules. These practices required systematic notation. Physicians increasingly modeled themselves on Hippocrates, recording details of cases as the basis for reasoned expositions of the histories of disease. Medical records, as other scholars have demonstrated, shaped the production of medical knowledge. Instead, this article focuses on the nature of casebooks as artifacts of the medical encounter. It establishes that casebooks were serial records of practice, akin to diaries, testimonials, and registers; identifies extant English casebooks and the practices that led to their production and preservation; and concludes that the processes of writing, ordering, and preserving medical records are as important for understanding the medical encounter as the records themselves. PMID:25557513

  2. Does leadership style of modern matrons contribute to safer and more effective clinical services?

    PubMed

    Hill, Barry

    2017-03-30

    At the time of writing, the author was a modern matron in a surgical division of an NHS teaching hospital in London. This article considers the differences between leadership and management, and discusses the skills required by modern matrons to lead safe and successful clinical services. It also examines three leadership styles - transactional, transformational and situational - and their relevance to the role of modern matron.

  3. Alchemical poetry in medieval and early modern Europe: a preliminary survey and synthesis. Part II - Synthesis.

    PubMed

    Kahn, Didier

    2011-03-01

    This article provides a preliminary description of medieval and early modern alchemical poetry composed in Latin and in the principal vernacular languages of western Europe. It aims to distinguish the various genres in which this poetry flourished, and to identify the most representative aspects of each cultural epoch by considering the medieval and early modern periods in turn. Such a distinction (always somewhat artificial) between two broad historical periods may be justified by the appearance of new cultural phenomena that profoundly modified the character of early modern alchemical poetry: the ever-increasing importance of the prisca theologia, the alchemical interpretation of ancient mythology, and the rise of neo-Latin humanist poetry. Although early modern alchemy was marked by the appearance of new doctrines (notably the alchemical spiritus mundi and Paracelsianism), alchemical poetry was only superficially modified by criteria of a scientific nature, which therefore appear to be of lesser importance. This study falls into two parts. Part I provides a descriptive survey of extant poetry, and in Part II the results of the survey are analysed in order to highlight such distinctive features as the function of alchemical poetry, the influence of the book market on its evolution, its doctrinal content, and the question of whether any theory of alchemical poetry ever emerged. Part II is accompanied by an index of the authors and works cited in both parts.

  4. Modern Special Collections Cataloguing: A University of London Case Study

    ERIC Educational Resources Information Center

    Attar, K. E.

    2013-01-01

    Recent years have seen a growing emphasis on modern special collections (in themselves no new phenomenon), with a dichotomy between guidance for detailed cataloguing in "Descriptive Cataloging of Rare Materials (Books)" (DCRM(B), 2007) and the value of clearing cataloguing backlogs expeditiously. This article describes the De la Mare…

  5. Approaches to the History of Patients: From the Ancient World to Early Modern Europe.

    PubMed

    Stolberg, Michael

    2016-01-01

    This chapter looks from an early modernist's perspective at some of the major questions and methodological issues that writing the history of patients in the ancient world shares with similar work on Patientengeschichte in medieval and early modern Europe. It addresses, in particular, the problem of finding adequate sources that give access to the patients' experience of illness and medicine and highlights the potential as well as the limitations of using physicians' case histories for that purpose. It discusses the doctor-patient relationship as it emerges from these sources, and the impact of the patient's point of view on learned medical theory and practice. In conclusion, it pleads for a cautious and nuanced approach to the controversial issue of retrospective diagnosis, recommending that historians consistently ask in which contexts and in what way the application of modern diagnostic labels to pre-modern accounts of illness can truly contribute to a better historical understanding rather than distort it.

  6. Modern mammal origins: evolutionary grades in the Early Cretaceous of North America.

    PubMed

    Jacobs, L L; Winkler, D A; Murry, P A

    1989-07-01

    Major groups of modern mammals have their origins in the Mesozoic Era, yet the mammalian fossil record is generally poor for that time interval. Fundamental morphological changes that led to modern mammals are often represented by small samples of isolated teeth. Fortunately, functional wear facets on teeth allow prediction of the morphology of occluding teeth that may be unrepresented by fossils. A major step in mammalian evolution occurred in the Early Cretaceous with the evolution of tribosphenic molars, which characterize marsupials and placentals, the two most abundant and diverse extant groups of mammals. A tooth from the Early Cretaceous (110 million years before present) of Texas tests previous predictions (based on lower molars) of the morphology of upper molars in early tribosphenic dentitions. The lingual cusp (protocone) is primitively without shear facets, as expected, but the cheek side of the tooth is derived (advanced) in having distinctive cusps along the margin. The tooth, although distressingly inadequate to define many features of the organism, demonstrates unexpected morphological diversity at a strategic stage of mammalian evolution and falsifies previous claims of the earliest occurrence of true marsupials.

  7. Modern mammal origins: evolutionary grades in the Early Cretaceous of North America.

    PubMed Central

    Jacobs, L L; Winkler, D A; Murry, P A

    1989-01-01

    Major groups of modern mammals have their origins in the Mesozoic Era, yet the mammalian fossil record is generally poor for that time interval. Fundamental morphological changes that led to modern mammals are often represented by small samples of isolated teeth. Fortunately, functional wear facets on teeth allow prediction of the morphology of occluding teeth that may be unrepresented by fossils. A major step in mammalian evolution occurred in the Early Cretaceous with the evolution of tribosphenic molars, which characterize marsupials and placentals, the two most abundant and diverse extant groups of mammals. A tooth from the Early Cretaceous (110 million years before present) of Texas tests previous predictions (based on lower molars) of the morphology of upper molars in early tribosphenic dentitions. The lingual cusp (protocone) is primitively without shear facets, as expected, but the cheek side of the tooth is derived (advanced) in having distinctive cusps along the margin. The tooth, although distressingly inadequate to define many features of the organism, demonstrates unexpected morphological diversity at a strategic stage of mammalian evolution and falsifies previous claims of the earliest occurrence of true marsupials. Images PMID:2740336

  8. Formalization and Interaction: Toward a Comprehensive History of Technology-Related Knowledge in Early Modern Europe.

    PubMed

    Popplow, Marcus

    2015-12-01

    Recent critical approaches to what has conventionally been described as "scientific" and "technical" knowledge in early modern Europe have provided a wealth of new insights. So far, the various analytical concepts suggested by these studies have not yet been comprehensively discussed. The present essay argues that such comprehensive approaches might prove of special value for long-term and cross-cultural reflections on technology-related knowledge. As heuristic tools, the notions of "formalization" and "interaction" are proposed as part of alternative narratives to those highlighting the emergence of "science" as the most relevant development for technology-related knowledge in early modern Europe.

  9. Teaching Petrarchan and Anti-Petrarchan Discourses in Early Modern English Lyrics

    ERIC Educational Resources Information Center

    Ribes, Purificación

    2012-01-01

    The aim of the present article is to help students realize that Petrarchism has been an influential source of inspiration for Early Modern English lyrics. Its topics and conventions have lent themselves to a wide variety of appropriations which the present selection of texts for analysis tries to illustrate. A few telling examples from Spenser,…

  10. Socialising Nurse Probationers in the Late 19th and Early 20th Centuries--Relevance of Historical Reflection for Modern Policy Makers.

    ERIC Educational Resources Information Center

    Lorentzon, Maria

    2003-01-01

    Historical records from London hospitals in the late 19th-early 20th centuries were analyzed for their depiction of nursing trainees. Analysis reveals a strong emphasis on character traits rather than intellectual ability. In contrast, the literature of the last 3 decades shows a contemporary concern for nurses as knowledgeable doers. (Contains 31…

  11. Honor, brotherhood, and the corporate ethos of London's Barber-Surgeons' Company, 1570-1640.

    PubMed

    Chamberland, Celeste

    2009-07-01

    As the largest and most civically active body of medical practitioners in the late Tudor and early Stuart period, surgeons played a vital role in London's urban landscape, but remained precariously vulnerable to abasement due to the regular contact with death and disease necessitated by their work. Based on an analysis of guild records, printed surgical manuals, and conduct literature, this study explores the emergent corporate ethos of London's Barber-Surgeons' Company and addresses the identity formation of surgeons in the late-sixteenth and early-seventeenth centuries. By implementing codes of conduct and uniform standards of practice, punishing transgressions of propriety, and developing legislation to limit the activities of unlicensed and foreign practitioners, Company officers ardently sought social and occupational legitimacy within a milieu characterized by a tremendous emphasis on status and hierarchy. Rooted in methodology drawn from the social history of medicine and cultural anthropology, this study argues that in response to the persistent stigma associated with their work and London's increasingly prevalent culture of credit, surgeons, like other artisanal groups, sought to enhance their social legitimacy and occupational respectability by manipulating contemporary social rituals, reinforcing the honorable associations of their work, and preserving the veneer of brotherhood and camaraderie.

  12. Between Charity and Education: Orphans and Orphanages in Early Modern Times

    ERIC Educational Resources Information Center

    Jacobi, Juliane

    2009-01-01

    In early modern times orphans have been children who could not expect sufficient support from their family because of lack of at least one parent, in most cases the father. This article will clarify of whom we are talking if we talk about orphans and what have been the conditions of living in a society which was organised by a high variety of…

  13. A network-based framework for assessing infrastructure resilience: a case study of the London metro system.

    PubMed

    Chopra, Shauhrat S; Dillon, Trent; Bilec, Melissa M; Khanna, Vikas

    2016-05-01

    Modern society is increasingly dependent on the stability of a complex system of interdependent infrastructure sectors. It is imperative to build resilience of large-scale infrastructures like metro systems for addressing the threat of natural disasters and man-made attacks in urban areas. Analysis is needed to ensure that these systems are capable of withstanding and containing unexpected perturbations, and develop heuristic strategies for guiding the design of more resilient networks in the future. We present a comprehensive, multi-pronged framework that analyses information on network topology, spatial organization and passenger flow to understand the resilience of the London metro system. Topology of the London metro system is not fault tolerant in terms of maintaining connectivity at the periphery of the network since it does not exhibit small-world properties. The passenger strength distribution follows a power law, suggesting that while the London metro system is robust to random failures, it is vulnerable to disruptions on a few critical stations. The analysis further identifies particular sources of structural and functional vulnerabilities that need to be mitigated for improving the resilience of the London metro network. The insights from our framework provide useful strategies to build resilience for both existing and upcoming metro systems. © 2016 The Author(s).

  14. Alchemical poetry in medieval and early modern Europe: a preliminary survey and synthesis. Part I--Preliminary survey.

    PubMed

    Kahn, Didier

    2010-11-01

    This article provides a preliminary description of medieval and early modern alchemical poetry composed in Latin and in the principal vernacular languages of western Europe. It aims to distinguish the various genres in which this poetry flourished, and to identify the most representative aspects of each cultural epoch by considering the medieval and early modern periods in turn. Such a distinction (always somewhat artificial) between two broad historical periods may be justified by the appearance of new cultural phenomena that profoundly modified the character of early modern alchemical poetry: the ever-increasing importance of the prisca theologia, the alchemical interpretation of ancient mythology, and the rise of neo-Latin humanist poetry. Although early modern alchemy was marked by the appearance of new doctrines (notably the alchemical spiritus mundi and Paracelsianism), alchemical poetry was only superficially modified by criteria of a scientific nature, which therefore appear to be of lesser importance. This study falls into two parts. Part I provides a descriptive survey of extant poetry, and in Part II the results of the survey are analysed in order to highlight such distinctive features as the function of alchemical poetry, the influence of the book market on its evolution, its doctrinal content, and the question of whether any theory of alchemical poetry ever emerged. Part II is accompanied by an index of the authors and works cited in both parts.

  15. "Against all hushing up and stamping down": the Medico-Psychological Clinic of London and the novelist May Sinclair.

    PubMed

    Martindale, Philippa

    2004-01-01

    May Sinclair (1863-1946) was one of the first modern novelists to appropriate psychoanalytic theories in her works. She was an early reader of the new psychoanalytic techniques but, rather than embracing its theories wholeheartedly and unquestioningly, she synthesized those that appealed to her own psychology of womanhood. Moreover, Sinclair's position was a unique one. As well as a highly acclaimed novelist with a respected public voice, she was closely associated with the setting up of one of the first psychotherapeutic centres in Britain, the Medico-Psychological Clinic of London. In this paper, I argue that the eclectic psychoanalytic situations in which Sinclair places her literary heroines mirror the eclectic and potentially feminist endeavours of the medico-Psychological Clinic. I draw upon archival material, hitherto unexamined by literary critics and medical historians, to reflect upon the turbulent lifespan of the Clinic and the attempts to curtail its controversial practices.

  16. A never-ending succession of epidemics? Mortality in early-modern York.

    PubMed

    Galley, C

    1994-04-01

    Early-modern cities are often perceived to be centres of high mortality and under constant siege from a barrage of epidemics. However, few urban mortality rates have been calculated and by employing parish register evidence from the regional capital of York, the thesis that the city was subjected to continual sudden increases in mortality can be firmly rejected. Infant mortality was high but remained virtually constant between 1561 and 1700. About a quarter of all infants did not survive to reach their first birthday and neonatal mortality was especially severe. From the mid-seventeenth century a series of epidemics increased child mortality although overall levels of mortality were not significantly affected. Relatively little can be said about adult mortality and apart from two periods of 'crisis' mortality there is little to suggest that adults were greatly affected by epidemics. Indeed, for many adults the urban environment appears to have posed no great threat to health and most could look forward to a relatively long life in the city. York's mortality regime was very similar to that of the smaller market town of Gainsborough where high levels of mortality remained stable throughout much of the early-modern period.

  17. How do you modernize a health service? A realist evaluation of whole-scale transformation in london.

    PubMed

    Greenhalgh, Trisha; Humphrey, Charlotte; Hughes, Jane; Macfarlane, Fraser; Butler, Ceri; Pawson, Ray

    2009-06-01

    Large-scale, whole-systems interventions in health care require imaginative approaches to evaluation that go beyond assessing progress against predefined goals and milestones. This project evaluated a major change effort in inner London, funded by a charitable donation of approximately $21 million, which spanned four large health care organizations, covered three services (stroke, kidney, and sexual health), and sought to "modernize" these services with a view to making health care more efficient, effective, and patient centered. This organizational case study draws on the principles of realist evaluation, a largely qualitative approach that is centrally concerned with testing and refining program theories by exploring the complex and dynamic interaction among context, mechanism, and outcome. This approach used multiple data sources and methods in a pragmatic and reflexive manner to build a picture of the case and follow its fortunes over the three-year study period. The methods included ethnographic observation, semistructured interviews, and scrutiny of documents and other contemporaneous materials. As well as providing ongoing formative feedback to the change teams in specific areas of activity, we undertook a more abstract, interpretive analysis, which explored the context-mechanism-outcome relationship using the guiding question "what works, for whom, under what circumstances?" In this example of large-scale service transformation, numerous projects and subprojects emerged, fed into one another, and evolved over time. Six broad mechanisms appeared to be driving the efforts of change agents: integrating services across providers, finding and using evidence, involving service users in the modernization effort, supporting self-care, developing the workforce, and extending the range of services. Within each of these mechanisms, different teams chose widely differing approaches and met with differing success. The realist analysis of the fortunes of different

  18. Marginalia, commonplaces, and correspondence: scribal exchange in early modern science.

    PubMed

    Yale, Elizabeth

    2011-06-01

    In recent years, historians of science have increasingly turned their attention to the "print culture" of early modern science. These studies have revealed that printing, as both a technology and a social and economic system, structured the forms and meanings of natural knowledge. Yet in early modern Europe, naturalists, including John Aubrey, John Evelyn, and John Ray, whose work is discussed in this paper, often shared and read scientific texts in manuscript either before or in lieu of printing. Scribal exchange, exemplified in the circulation of writings like commonplace books, marginalia, manuscript treatises, and correspondence, was the primary means by which communities of naturalists constructed scientific knowledge. Print and manuscript were necessary partners. Manuscript fostered close collaboration, and could be circulated relatively cheaply; but, unlike print, it could not reliably secure priority or survival for posterity. Naturalists approached scribal and print communication strategically, choosing the medium that best suited their goals at any given moment. As a result, print and scribal modes of disseminating information, constructing natural knowledge, and organizing communities developed in tandem. Practices typically associated with print culture manifested themselves in scribal texts and exchanges, and vice versa. "Print culture" cannot be hived off from "scribal culture." Rather, in their daily jottings and exchanges, naturalists inhabited, and produced, one common culture of communication. Copyright © 2010 Elsevier Ltd. All rights reserved.

  19. Kant's disputation of 1770: the dissertation and the communication of knowledge in early modern Europe.

    PubMed

    Chang, Kevin

    2007-06-01

    Kant's disputation of 1770 at his inauguration as the metaphysics professor at Königsberg is a good example of the nature of the early modern dissertation and its use as a means of communicating knowledge. The public disputation played an important part in the teaching, examination, publication and ceremonial life of the medieval university. Originally prepared as a text for the public disputation, the dissertation communicated the teachings of individual scholars and institutions and was used by eminent early modern scholars to introduce their ideas and findings. Kant's use of his 1770 disputation also reveals the different channels of communication, both private and public, that paid close attention to knowledge published in dissertations.

  20. Plant foods and the dietary ecology of Neanderthals and early modern humans.

    PubMed

    Henry, Amanda G; Brooks, Alison S; Piperno, Dolores R

    2014-04-01

    One of the most important challenges in anthropology is understanding the disappearance of Neanderthals. Previous research suggests that Neanderthals had a narrower diet than early modern humans, in part because they lacked various social and technological advances that lead to greater dietary variety, such as a sexual division of labor and the use of complex projectile weapons. The wider diet of early modern humans would have provided more calories and nutrients, increasing fertility, decreasing mortality and supporting large population sizes, allowing them to out-compete Neanderthals. However, this model for Neanderthal dietary behavior is based on analysis of animal remains, stable isotopes, and other methods that provide evidence only of animal food in the diet. This model does not take into account the potential role of plant food. Here we present results from the first broad comparison of plant foods in the diets of Neanderthals and early modern humans from several populations in Europe, the Near East, and Africa. Our data comes from the analysis of plant microremains (starch grains and phytoliths) in dental calculus and on stone tools. Our results suggest that both species consumed a similarly wide array of plant foods, including foods that are often considered low-ranked, like underground storage organs and grass seeds. Plants were consumed across the entire range of individuals and sites we examined, and none of the expected predictors of variation (species, geographic region, or associated stone tool technology) had a strong influence on the number of plant species consumed. Our data suggest that Neanderthal dietary ecology was more complex than previously thought. This implies that the relationship between Neanderthal technology, social behavior, and food acquisition strategies must be better explored. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. Patterns and prevalence of violence-related skull trauma in medieval London.

    PubMed

    Krakowka, Kathryn

    2017-11-01

    This study aims to identify the patterns and prevalence of violence-related skull trauma (including the cranium and mandible) among a large sample of skeletons from medieval London (1050-1550 AD). In total, data from 399 skulls, representing six different sites from across medieval London, were analyzed for evidence of trauma and assessed for the likelihood that it was caused by violence. The sites include the three parish cemeteries of St Nicholas Shambles (GPO75), St Lawrence Jewry (GYE92), and St Benet Sherehog (ONE94); the two monastic houses of London Blackfriars (PIC87) and St Mary Graces (MIN86); and the early inmate cemetery from the medieval hospital of St Mary Spital (NRT85). The overall findings suggest that violence affected all aspects of medieval London society, but how that violence was characterized largely depended on sex and burial location. Specifically, males from the lay cemeteries appear to have been the demographic most affected by violence-related skull injuries, particularly blunt force trauma to the cranial vault. Using both archaeological and historical evidence, the results suggest that violence in medieval London may have been more prevalent than in other parts of medieval England, particularly rural environments, but similar to other parts of medieval Europe. However, more studies focusing on medieval trauma, and violence specifically, need to be carried out to further strengthen these results. In particular, males from the lay cemeteries were disproportionately affected by violence-related trauma, especially blunt force trauma. It perhaps indicates a means of informal conflict resolution as those of lower status did not always have the newly established medieval legal system available to them. © 2017 Wiley Periodicals, Inc.

  2. Beck, Asia and second modernity.

    PubMed

    Calhoun, Craig

    2010-09-01

    The work of Ulrich Beck has been important in bringing sociological attention to the ways issues of risk are embedded in contemporary globalization, in developing a theory of 'reflexive modernization', and in calling for social science to transcend 'methodological nationalism'. In recent studies, he and his colleagues help to correct for the Western bias of many accounts of cosmopolitanism and reflexive modernization, and seek to distinguish normative goals from empirical analysis. In this paper I argue that further clarification of this latter distinction is needed but hard to reach within a framework that still embeds the normative account in the idea that empirical change has a clear direction. Similar issues beset the presentation of diverse patterns in recent history as all variants of 'second modernity'. Lastly, I note that ironically, given the declared 'methodological cosmopolitanism' of the authors, the empirical studies here all focus on national cases. © London School of Economics and Political Science 2010.

  3. "The Root is Hidden and the Material Uncertain": the challenges of prosecuting witchcraft in early modern Venice.

    PubMed

    Seitz, Jonathan

    2009-01-01

    The rich archival records of the Holy Office of the Inquisition in Venice have yielded much information about early modern society and culture. The transcripts of witchcraft trials held before the Inquisition reveal the complexities of early modern conceptions of natural and supernatural. The tribunal found itself entirely unable to convict individuals charged with performing harmful magic, or maleficio, as different worldviews clashed in the courtroom. Physicians, exorcists, and inquisitors all had different approaches to distinguishing natural phenomena from supernatural, and without a consensus guilty verdicts could not be obtained.

  4. Non-London electrodynamics in a multiband London model: Anisotropy-induced nonlocalities and multiple magnetic field penetration lengths

    NASA Astrophysics Data System (ADS)

    Silaev, Mihail; Winyard, Thomas; Babaev, Egor

    2018-05-01

    The London model describes strongly type-2 superconductors as massive vector field theories, where the magnetic field decays exponentially at the length scale of the London penetration length. This also holds for isotropic multiband extensions, where the presence of multiple bands merely renormalizes the London penetration length. We show that, by contrast, the magnetic properties of anisotropic multiband London models are not this simple, and the anisotropy leads to the interband phase differences becoming coupled to the magnetic field. This results in the magnetic field in such systems having N +1 penetration lengths, where N is the number of field components or bands. That is, in a given direction, the magnetic field decay is described by N +1 modes with different amplitudes and different decay length scales. For certain anisotropies we obtain magnetic modes with complex masses. That means that magnetic field decay is not described by a monotonic exponential increment set by a real penetration length but instead is oscillating. Some of the penetration lengths are shown to diverge away from the superconducting phase transition when the mass of the phase-difference mode vanishes. Finally the anisotropy-driven hybridization of the London mode with the Leggett modes can provide an effectively nonlocal magnetic response in the nominally local London model. Focusing on the two-component model, we discuss the magnetic field inversion that results from the effective nonlocality, both near the surface of the superconductor and around vortices. In the regime where the magnetic field decay becomes nonmonotonic, the multiband London superconductor is shown to form weakly-bound states of vortices.

  5. Smallpox vaccination: an early start of modern medicine in America.

    PubMed

    Liebowitz, Dan

    2017-01-01

    Smallpox was eradicated by the World Health Organization in 1980. Before its eradication thedisease had a mortality rate upwards of 50% and had a significant impact on society. During theAmerican Revolutionary war, smallpox outbreaks were impeding the American war effort until1777 when George Washington carried out a mass inoculation campaign in the ContinentalArmy that reduced the mortality from smallpox to less than 2%. Inoculation was an early formof vaccination that used live virus from active pustules to induce a milder, but still sometimesdeadly, case of disease. Washington has been credited with helping to ease the burden ofsmallpox on the Army which improved the odds of success against the British. When EdwardJenner's vaccine reached America it was more readily accepted by political and medical leadersdue the success of Washington's inoculation campaign. The Founding Fathers argued thatsmallpox vaccination was the greatest discovery in modern medicine and they were likely correctthat it helped to usher in the modern era of vaccinology.

  6. John Lawson's "A New Voyage to Carolina": notes on the publication history of the London (1709) edition.

    PubMed

    Simpson, Marcus B; Simpson, Sallie W

    2008-01-01

    John Lawson's "A New Voyage to Carolina," an important source document for American colonial natural history, was first printed in 1709 in "A New Collection of Voyages and Travels," a two-volume set that also contained travel books translated by John Stevens. Lawson's publishers were leaders in the book trade of early eighteenth century London, and the "New Voyage" is typical of the resurgent popular interest in foreign travel narratives and exotic flora and fauna that began in the late 1600s. The "New Collection" was among the earliest examples of books published in serial instalments or fascicles, a marketing strategy adopted by London booksellers to broaden the audience and increase sales. Analysis of London issues of the "New Voyage" indicates that the 1709, 1711, 1714, and 1718 versions are simply bindings of the original, unsold sheets from the 1709 "New Collection" edition, differing only by new title-pages, front matter, and random stop-press corrections of type-set errors. Lawson's "New Voyage" illustrates important aspects of the British book trade during the hand press period of the early eighteenth century.

  7. Testing Drugs and Trying Cures: Experiment and Medicine in Medieval and Early Modern Europe.

    PubMed

    Leong, Elaine; Rankin, Alisha

    2017-01-01

    This article examines traditions of testing drugs (as substances) and trying cures (on patients) in medieval and early modern Europe. It argues that the history of drug testing needs to be a more central story to overall histories of scientific experiment. The practice of conducting thoughtful-and sometimes contrived-tests on drugs has a rich and varied tradition dating back to antiquity, which expanded in the Middle Ages and early modern period. Learned physicians paired text-based knowledge (reason) with hands-on testing (experience or experiment) in order to make claims about drugs' properties or effects on humans. Lay practitioners similarly used hands-on testing to gain knowledge of pharmaceutical effects. Although drug testing practices expanded in scale, actors, and sites, therpublished a work extolling the virtues of drugs froe was significant continuity from the Middle Ages to the eighteenth century.

  8. Resistant tissues of modern marchantioid liverworts resemble enigmatic Early Paleozoic microfossils

    PubMed Central

    Graham, Linda E.; Wilcox, Lee W.; Cook, Martha E.; Gensel, Patricia G.

    2004-01-01

    Absence of a substantial pretracheophyte fossil record for bryophytes (otherwise predicted by molecular systematics) poses a major problem in our understanding of earliest land-plant structure. In contrast, there exist enigmatic Cambrian–Devonian microfossils (aggregations of tubes or sheets of cells or possibly a combination of both) controversially interpreted as an extinct group of early land plants known as nematophytes. We used an innovative approach to explore these issues: comparison of tube and cell-sheet microfossils with experimentally degraded modern liverworts as analogues of ancient early land plants. Lower epidermal surface tissues, including rhizoids, of Marchantia polymorpha and Conocephalum conicum were resistant to breakdown after rotting for extended periods or high-temperature acid treatment (acetolysis), suggesting fossilization potential. Cell-sheet and rhizoid remains occurred separately or together depending on the degree of body degradation. Rhizoid break-off at the lower epidermal surface left rimmed pores at the centers of cell rosettes; these were similar in structure, diameter, and distribution to pores characterizing nematophyte cell-sheet microfossils known as Cosmochlaina. The range of Marchantia rhizoid diameters overlapped that of Cosmochlaina pores. Approximately 14% of dry biomass of Marchantia vegetative thalli and 40% of gametangiophores was resistant to acetolysis. Pre- and posttreatment cell-wall autofluorescence suggested the presence of phenolic compounds that likely protect lower epidermal tissues from soil microbe attack and provide dimensional stability to gametangiophores. Our results suggest that at least some microfossils identified as nematophytes may be the remains of early marchantioid liverworts similar in some ways to modern Marchantia and Conocephalum. PMID:15263095

  9. EUFEMED London Conference 2017: Exploratory Medicines Development: Innovation and Risk Management.

    PubMed

    Van Bortel, Luc; Sourgens, Hildegard; Breithaupt-Grögler, Kerstin; Caplain, Henri; Donazzolo, Yves; Klingmann, Ingrid; Hammond, Michael; Hardman, Timothy C; Stringer, Steffan; de Hoon, Jan

    2017-01-01

    The first formal conference of the EUropean Federation for Exploratory MEdicines Development (EUFEMED) held in London was the result of a collaborative effort of its founding associations: the Association for Applied Human Pharmacology (AGAH; Germany), the Association for Human Pharmacology in the Pharmaceutical Industry (AHPPI; UK), the Belgian Association of Phase-I Units (BAPU; Belgium), and Club Phase-I (France). The conference focused on innovation and risk management in early clinical drug development. Among other innovations, immunotherapy in oncology and inflammatory diseases were discussed as well as the importance of adaptive trial designs in early clinical drug development. Consideration was given to assessing and mitigating risk in early clinical drug development, and included a preconference workshop. Different measures to minimize risks in healthy volunteers and patients in first-in-human trials were discussed in addition to the importance of non-clinical data, the need for reliable biomarkers, improved communication on adverse events (AEs) and well-trained study sites with ready access to intensive care units and clinical specialists. The need for a European-wide system for prevention of over-volunteering was also discussed. The conference provided opportunity to discuss these developments and concerns and the changing regulatory environment with stakeholders from academia, industry, and regulatory agencies including the European Medicines Agency (EMA). Presentations given by invited speakers are published on http://www.eufemed.eu/london-conference-2017/.

  10. London International Youth Science Forum

    ERIC Educational Resources Information Center

    Auty, Geoff

    2010-01-01

    In this article, the author discusses the 2010 London International Youth Science Forum (LIYSF) and shares his experience in attending the forum. Unlike the Harry Messel event in Sydney, which takes place every two years, LIYSF is an annual event. Before moving to Imperial College London, LIYSF was held at the Institute of Electrical Engineers and…

  11. London: An Art Teacher's Inspiration

    ERIC Educational Resources Information Center

    Guhin, Paula

    2012-01-01

    Often overshadowed in people's minds by Paris, London is truly an artist's jewel. The art and architecture, history, gardens and museums are inspiring, yes, but there's so much more to this ancient city. The performances, attractions and markets are a boon to the creative soul. London can be surprisingly inexpensive to visit. Gazing at statues,…

  12. 19th century London dust-yards: a case study in closed-loop resource efficiency.

    PubMed

    Velis, Costas A; Wilson, David C; Cheeseman, Christopher R

    2009-04-01

    The material recovery methods used by dust-yards in early 19th century London, England and the conditions that led to their development, success and decline are reported. The overall system developed in response to the market value of constituents of municipal waste, and particularly the high coal ash content of household 'dust'. The emergence of lucrative markets for 'soil' and 'breeze' products encouraged dust-contractors to recover effectively 100% of the residual wastes remaining after readily saleable items and materials had been removed by the thriving informal sector. Contracting dust collection to the private sector allowed parishes to keep the streets relatively clean, without the need to develop institutional capacity, and for a period this also generated useful income. The dust-yard system is, therefore, an early example of organised, municipal-wide solid waste management, and also of public-private sector participation. The dust-yard system had been working successfully for more than 50 years before the Public Health Acts of 1848 and 1875, and was thus important in facilitating a relatively smooth transition to an institutionalised, municipally-run solid waste management system in England. The dust-yards can be seen as early precursors of modern materials recycling facilities (MRFs) and mechanical-biological treatment (MBT) plants; however, it must be emphasised that dust-yards operated without any of the environmental and occupational health considerations that are indispensable today. In addition, there are analogies between dust-yards and informal sector recycling systems currently operating in many developing countries.

  13. Age Differences in Strategic Planning as Indexed by the Tower of London

    ERIC Educational Resources Information Center

    Albert, Dustin; Steinberg, Laurence

    2011-01-01

    The present study examined age differences in performance on the Tower of London, a measure of strategic planning, in a diverse sample of 890 individuals between the ages of 10 and 30. Although mature performance was attained by age 17 on relatively easy problems, performance on the hardest problems showed improvements into the early 20s.…

  14. Early modern human settlement of Europe north of the Alps occurred 43,500 years ago in a cold steppe-type environment

    PubMed Central

    Nigst, Philip R.; Haesaerts, Paul; Damblon, Freddy; Frank-Fellner, Christa; Mallol, Carolina; Viola, Bence; Götzinger, Michael; Niven, Laura; Trnka, Gerhard; Hublin, Jean-Jacques

    2014-01-01

    The first settlement of Europe by modern humans is thought to have occurred between 50,000 and 40,000 calendar years ago (cal B.P.). In Europe, modern human remains of this time period are scarce and often are not associated with archaeology or originate from old excavations with no contextual information. Hence, the behavior of the first modern humans in Europe is still unknown. Aurignacian assemblages—demonstrably made by modern humans—are commonly used as proxies for the presence of fully behaviorally and anatomically modern humans. The site of Willendorf II (Austria) is well known for its Early Upper Paleolithic horizons, which are among the oldest in Europe. However, their age and attribution to the Aurignacian remain an issue of debate. Here, we show that archaeological horizon 3 (AH 3) consists of faunal remains and Early Aurignacian lithic artifacts. By using stratigraphic, paleoenvironmental, and chronological data, AH 3 is ascribed to the onset of Greenland Interstadial 11, around 43,500 cal B.P., and thus is older than any other Aurignacian assemblage. Furthermore, the AH 3 assemblage overlaps with the latest directly radiocarbon-dated Neanderthal remains, suggesting that Neanderthal and modern human presence overlapped in Europe for some millennia, possibly at rather close geographical range. Most importantly, for the first time to our knowledge, we have a high-resolution environmental context for an Early Aurignacian site in Central Europe, demonstrating an early appearance of behaviorally modern humans in a medium-cold steppe-type environment with some boreal trees along valleys around 43,500 cal B.P. PMID:25246543

  15. Killer smog of London, 50 years on: particle properties and oxidative capacity.

    PubMed

    Whittaker, Andy; BéruBé, Kelly; Jones, Tim; Maynard, Robert; Richards, Roy

    2004-12-01

    Total suspended particulate (TSP) samples collected on glass fibre filters in London before (1955) and after (1958-1974) the Clean Air Act was examined for physicochemical characteristics and oxidative capacity. High-resolution microscopy identified most of the material as soot with smelter spheres, fly ash (FA), sodium chloride and calcium sulphate particles. Image analysis (IA) was used to show that most of the soot aggregates were less than 1 microm in size and contained chains of individual particles of 10-50 nm. Speed mapping of large agglomerates of the historic particles confirmed that the samples were enriched with soot probably derived from a sulphur-rich coal called nutty slack which was used extensively at this time. Inductively coupled plasma-mass spectrometry (ICP-MS) was used to examine elemental composition. Meaningful quantitation of certain elements (Mg, Al and Zn) proved impossible because they were in high quantities in the glass fibre filters. However, high quantities of Fe>Pb>Cu>Mn>V>As were detected which may explain in part the bioreactivity of the samples. Using a simple in vitro test of oxidative capacity (plasmid assay), one historic particulate sample (1958) showed three times the activity of a modern-day diesel exhaust particle (DEP) sample but ten times less activity than a modern-day urban ambient particle collection. Such studies are continuing to link particle physicochemical properties and bioreactivity with a wider range of the samples collected between 1955 and 74 and how such historic samples compare with present-day London ambient particles.

  16. Collecting Knowledge for the Family: Recipes, Gender and Practical Knowledge in the Early Modern English Household

    PubMed Central

    Leong, Elaine

    2013-01-01

    When Mary Cholmeley married Henry Fairfax in 1627, she carried to her new home in Yorkshire a leather-bound notebook filled with medical recipes. Over the next few decades, Mary and Henry, their children and various members of the Fairfax and Cholmeley families continually entered new medical and culinary information into this ‘treasury for health.’ Consequently, as it stands now, the manuscript can be read both as a repository of household medical knowledge and as a family archive. Focusing on two Fairfax ‘family books,’ this essay traces on the process through which early modern recipe books were created. In particular, it explores the role of the family collective in compiling books of knowledge. In contrast to past studies where household recipe books have largely been described as the products of exclusively female endeavors, I argue that the majority of early modern recipe collections were created by family collectives and that the members of these collectives worked in collaboration across spatial, geographical and temporal boundaries. This new reading of recipe books as testaments of the interests and needs of particular families encourages renewed examination of the role played by gender in the transmission and production of knowledge in early modern households. PMID:23926360

  17. Collecting Knowledge for the Family: Recipes, Gender and Practical Knowledge in the Early Modern English Household.

    PubMed

    Leong, Elaine

    2013-05-01

    When Mary Cholmeley married Henry Fairfax in 1627, she carried to her new home in Yorkshire a leather-bound notebook filled with medical recipes. Over the next few decades, Mary and Henry, their children and various members of the Fairfax and Cholmeley families continually entered new medical and culinary information into this 'treasury for health.' Consequently, as it stands now, the manuscript can be read both as a repository of household medical knowledge and as a family archive. Focusing on two Fairfax 'family books,' this essay traces on the process through which early modern recipe books were created. In particular, it explores the role of the family collective in compiling books of knowledge. In contrast to past studies where household recipe books have largely been described as the products of exclusively female endeavors, I argue that the majority of early modern recipe collections were created by family collectives and that the members of these collectives worked in collaboration across spatial, geographical and temporal boundaries. This new reading of recipe books as testaments of the interests and needs of particular families encourages renewed examination of the role played by gender in the transmission and production of knowledge in early modern households.

  18. Optical legacy of Imperial College London

    NASA Astrophysics Data System (ADS)

    Kidger Webb-Moore, Tina E.

    2016-10-01

    The Industrial Revolution, beginning primarily in the UK, generated an increasing need for highly skilled technical people. Throughout the 19th century, technical instruction increased dramatically and the formation of schools specializing in science and technology grew quickly. In England, there was much motivation in favour of a national prestige center for science and technology centered in London. Central among the motivating forces was Queen Victoria's husband, Prince Albert. Although there were already existing specialist science and technology institutions in major English cities, the growth of superior institutions in other countries within Europe, especially Germany and the Charlottenburg area of Berlin (e.g., the Berlin Technical High School), encouraged important English dignitaries to become more competitive with continental Europe. As a result of this strong continental motivation, several science and technology institutions were built in the south Kensington part of London during the latter half of the 19th century. Imperial College, founded at the start of the 20th century, was a culmination and consolidation of several of these 19th century English institutions. Optical science and technology was an early beneficiary of the founding of Imperial College. This paper will attempt to provide the reader with an understanding of how great was the influence of the optical section of Imperial College in the further development of the world's optical science and technology.

  19. King’s College London, a cardiac centre of excellence: will it only be possible to deliver the best cardiovascular medicine in 'capital cities' in the future?

    PubMed

    2011-09-01

    New developments at King's College, London, suggest that the complexity of modern cardiovascular medicine, and the enormous prospects for future advances, means that smaller cities will find it hard to compete, reports Barry Shurlock, MA, PhD.

  20. Hippocrates' complaint and the scientific ethos in early modern England.

    PubMed

    Yeo, Richard

    2018-04-01

    Among the elements of the modern scientific ethos, as identified by R.K. Merton and others, is the commitment of individual effort to a long-term inquiry that may not bring substantial results in a lifetime. The challenge this presents was encapsulated in the aphorism of the ancient Greek physician, Hippocrates of Kos: vita brevis, ars longa (life is short, art is long). This article explores how this complaint was answered in the early modern period by Francis Bacon's call for the inauguration of the sciences over several generations, thereby imagining a succession of lives added together over time. However, Bacon also explored another response to Hippocrates: the devotion of a 'whole life', whether brief or long, to science. The endorsement of long-term inquiry in combination with intensive lifetime involvement was embraced by some leading Fellows of the Royal Society, such as Robert Boyle and Robert Hooke. The problem for individuals, however, was to find satisfaction in science despite concerns, in some fields, that current observations and experiments would not yield material able to be extended by future investigations.

  1. A Step towards Clerical Preferment: Secondary School Teachers' Careers in Early Modern Sweden

    ERIC Educational Resources Information Center

    Lindmark, Daniel

    2004-01-01

    This article investigates the function served by embarking on a teaching career in the Latin school system for recruitment to the clergy in early modern Sweden. The study is restricted to the eighty-nine teachers serving at Pitea Grammar School in Northern Sweden in the period from 1650 to 1849. The investigation pays considerable attention to the…

  2. Early Upper Paleolithic in Eastern Europe and implications for the dispersal of modern humans.

    PubMed

    Anikovich, M V; Sinitsyn, A A; Hoffecker, John F; Holliday, Vance T; Popov, V V; Lisitsyn, S N; Forman, Steven L; Levkovskaya, G M; Pospelova, G A; Kuz'mina, I E; Burova, N D; Goldberg, Paul; Macphail, Richard I; Giaccio, Biagio; Praslov, N D

    2007-01-12

    Radiocarbon and optically stimulated luminescence dating and magnetic stratigraphy indicate Upper Paleolithic occupation-probably representing modern humans-at archaeological sites on the Don River in Russia 45,000 to 42,000 years ago. The oldest levels at Kostenki underlie a volcanic ash horizon identified as the Campanian Ignimbrite Y5 tephra that is dated elsewhere to about 40,000 years ago. The occupation layers contain bone and ivory artifacts, including possible figurative art, and fossil shells imported more than 500 kilometers. Thus, modern humans appeared on the central plain of Eastern Europe as early as anywhere else in northern Eurasia.

  3. Voluntarist theology and early-modern science: The matter of the divine power, absolute and ordained.

    PubMed

    Oakley, Francis

    2018-03-01

    This paper is an intervention in the debate inaugurated by Peter Harrison in 2002 when he called into question the validity of what has come to be called 'the voluntarism and early-modern science thesis'. Though it subsequently drew support from such historians of science as J. E. McGuire, Margaret Osler, and Betty-Joe Teeter Dobbs, the origins of the thesis are usually traced back to articles published in 1934 and 1961 respectively by the philosopher Michael Foster and the historian of ideas Francis Oakley. Central to Harrison's critique of the thesis are claims he made about the meaning of the scholastic distinction between the potentia dei absoluta et ordinata and the role it played in the thinking of early-modern theologians and natural philosophers. This paper calls directly into question the accuracy of Harrison's claims on that very matter.

  4. [Mental interiority in the early-modern age. The "Cartesian theater"].

    PubMed

    Gillot, Pascale

    2010-01-01

    This paper looks into the notion of mental interiority in the early-modern age and, more specifically, into the Cartesian conception of the mind as an "inner theater". The main claim emphasizes a close connexion at work between the representative theory of the mind, associated with internalism, on the one hand, and a "neuropsychological" view on the other hand. Cartesian mentalism, in so far as it is based upon a disjunction between representation and resemblance, can therefore not be separated from the general project, already at work in the Dioptrique, of an intra-cerebral localization of the mental.

  5. Institutional profile: the London Centre for Nanotechnology.

    PubMed

    Weston, David; Bontoux, Thierry

    2009-12-01

    Located in the London neighborhoods of Bloomsbury and South Kensington, the London Centre for Nanotechnology is a UK-based multidisciplinary research center that operates at the forefront of science and technology. It is a joint venture between two of the world's leading institutions, UCL and Imperial College London, uniting their strong capabilities in the disciplines that underpin nanotechnology: engineering, the physical sciences and biomedicine. The London Centre for Nanotechnology has a unique operating model that accesses and focuses the combined skills of the Departments of Chemistry, Physics, Materials, Medicine, Electrical and Electronic Engineering, Mechanical Engineering, Chemical Engineering, Biochemical Engineering and Earth Sciences across the two universities. It aims to provide the nanoscience and nanotechnology required to solve major problems in healthcare, information processing, energy and the environment.

  6. Translation, Hybridization, and Modernization: John Dewey and Children's Literature in Early Twentieth Century China

    ERIC Educational Resources Information Center

    Xu, Xu

    2013-01-01

    This essay examines how John Dewey's child-centered educational philosophy was adopted and adapted in the early twentieth century in China to create a Chinese children's literature. Chinese intellectuals applied Dewey's educational philosophy, which values children's interests and needs, to formulate a new concept of modern childhood that…

  7. The Modern Value of Early Writings in Medicine and Dentistry.

    PubMed

    Peck, Sheldon

    2016-01-01

    This article illustrates three examples supporting the modern value of early writings in dentistry and medicine. First, by studying cases described in works published long before the era of genetic science, we are able to develop new hypotheses about familial conditions and their genetic roots. Tooth transposition is presented as an example. Second, old writings may lead us to valuable historical insights and perspectives in medicine that can be revealed only in retrospective analysis. An example of this kind of historical analysis uncovers why dentistry became unnaturally separated from mainstream medicine in the 19th century. Third, early writings become keys to unlocking forgotten knowledge that enriches our understanding of historically significant people and events. The discovery of Norman Kingsley's long forgotten pyrographic paintings after Rembrandt portraits is used as an example. Libraries, the traditional custodians of these valued old texts, must continue to be supported, and not undermined by the paperless digital revolution. Copyright American Academy of the History of Dentistry.

  8. "None Must Meddle Betueene Man and Wife": assessing family and the fluidity of public and private in early modern Scotland.

    PubMed

    Nugent, Janay

    2010-01-01

    The physical and ideological boundaries between public and private in early modern Scotland were constantly contested, resulting in a shifting reality of what was public and private. This fluidity has been recognized by historians, but how, when, and why the shifting took place is not as clear. The moral church courts (Kirk Sessions) of Reformation Scotland allow a unique opportunity to begin to understand the largely elusive boundaries between public and private in the early modern era.

  9. London's Jewish Communities and State Education

    ERIC Educational Resources Information Center

    Martin, Jane

    2012-01-01

    The Inner London education authority was a notable example of a radical and powerful local government body from which the fight for the comprehensive principle in English secondary education emerged. Building on previous work of women's contribution to state education in London, this articles focuses on Anglo-Jewish educator activists who helped…

  10. Origin of Clothing Lice Indicates Early Clothing Use by Anatomically Modern Humans in Africa

    PubMed Central

    Toups, Melissa A.; Kitchen, Andrew; Light, Jessica E.; Reed, David L.

    2011-01-01

    Clothing use is an important modern behavior that contributed to the successful expansion of humans into higher latitudes and cold climates. Previous research suggests that clothing use originated anywhere between 40,000 and 3 Ma, though there is little direct archaeological, fossil, or genetic evidence to support more specific estimates. Since clothing lice evolved from head louse ancestors once humans adopted clothing, dating the emergence of clothing lice may provide more specific estimates of the origin of clothing use. Here, we use a Bayesian coalescent modeling approach to estimate that clothing lice diverged from head louse ancestors at least by 83,000 and possibly as early as 170,000 years ago. Our analysis suggests that the use of clothing likely originated with anatomically modern humans in Africa and reinforces a broad trend of modern human developments in Africa during the Middle to Late Pleistocene. PMID:20823373

  11. Juan Ruiz De Alarcón: Impairment as Empowerment in Early Modern Spain

    ERIC Educational Resources Information Center

    Clark, Gloria Bodtorf

    2016-01-01

    Juan Ruiz de Alarcón, a seventeenth-century writer and native of New Spain, so excelled at the craft of writing "comedias" that he is recognized as one of the great writers of early modern Spain. In his personal life Ruiz de Alarcón struggled with a significant bodily impairment, a large hump on both his back and front, which made him…

  12. The early argument for prefrontal leucotomy: the collision of frontal lobe theory and psychosurgery at the 1935 International Neurological Congress in London.

    PubMed

    Boettcher, Lillian B; Menacho, Sarah T

    2017-09-01

    The pathophysiology of mental illness and its relationship to the frontal lobe were subjects of immense interest in the latter half of the 19th century. Numerous studies emerged during this time on cortical localization and frontal lobe theory, drawing upon various ideas from neurology and psychiatry. Reflecting the intense interest in this region of the brain, the 1935 International Neurological Congress in London hosted a special session on the frontal lobe. Among other presentations, Yale physiologists John Fulton and Carlyle Jacobsen presented a study on frontal lobectomy in primates, and neurologist Richard Brickner presented a case of frontal ablation for olfactory meningioma performed by the Johns Hopkins neurosurgeon Walter Dandy. Both occurrences are said to have influenced Portuguese neurologist Egas Moniz (1874-1955) to commence performing leucotomies on patients beginning in late 1935. Here the authors review the relevant events related to frontal lobe theory leading up to the 1935 Neurological Congress as well as the extent of this meeting's role in the genesis of the modern era of psychosurgery.

  13. Glass and Alchemy in Early Modern Europe: An Analytical Study of Glassware from the Oberstockstall Laboratory in Austria.

    PubMed

    Veronesi, Umberto; Martinón-Torres, Marcos

    2018-06-18

    Glass distillation equipment from an early modern alchemical laboratory was analyzed for its technology of manufacture and potential origin. Chemical data show that the assemblage can be divided into sodium-rich, colorless distillation vessels made with glass from Venice or its European imitation, and potassium-rich dark-brown non-specialized forms produced within the technological tradition of forest glass typical for central and north-western Europe. These results complete our understanding of the supply of technical apparatus at one of the best-preserved alchemical laboratories and highlight an early awareness of the need for high-quality instruments to guarantee the successful outcome of specialized chemical operations. This study demonstrates the potential of archaeological science to inform historical research around the practice of early chemistry and the development of modern science. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. School Jailhouse: Discipline, Space and the Materiality of School Morale in Early-Modern Sweden

    ERIC Educational Resources Information Center

    Norlin, Björn

    2016-01-01

    This paper uses a specific phenomenon of early-modern education in Sweden, the school jail, as a point of departure for a broader analysis of educational policy in the areas of discipline and moral instruction. The paper demonstrates how the jail evolved as a part of a wider network of objects, pedagogical technologies and social routines in this…

  15. The Home Network: Identity and Materiality in Early Modern and Modern Ulster

    NASA Astrophysics Data System (ADS)

    Whalen, Kathryn M.

    This dissertation looks at three categories of ceramics and the creation of a hybrid culture during the Early Modern and Modern period in Ireland. During these time periods Ireland was a part of the English global colonial enterprises, and was the site of many legal and cultural changes due to its subordinate position in the hierarchy of socio-political and economic phenomenon that characterize the pinnacle of British global power. This study looks to understand how these powers articulated with England's one European colony, Ireland, and if that articulation has similarities to other colonial cultures across time and space. To study the possibility of hybridity between the Irish and English inhabitants of Ireland during the Post-Medieval Period, three categories of ceramics have been analyzed. Fine earthenwares in the form of tablewares and tea sets were macroscopically analyzed for patterns, age, and place of origin. Coarse earthenwares were subjected to X-ray florescence to look for patterns in the spectral data to see if a point of origin could be ascribed to them. And lastly, white ball clay pipe fragments were both macroscopically analyzed for makers' marks and subjected to X-ray florescence to verify their point of origin. The relationship between where these artifacts come from- if they are local productions or imports- and where they were disposed of- either across the landscaper or only associated with households of particular ethnicities- says something about how people negotiate their ethnic identities in colonial settings. As people in Ireland adopt the English style of tea drinking and start to use English mass-produced fine earthenwares, it disrupts the local cottage industry of coarse earthenware manufacturing. What this study seeks to know is if there is a difference in the adoption of English tea drinking, and if the purchasing of certain types of ceramic vessels contributes to the performance of ethnic identity in a colonial setting.

  16. Assessing an early modern Fenland population: Whittlesey (Cambridgeshire).

    PubMed

    Falvey, Heather

    2014-01-01

    Improvement writers argued that drainage would bring prosperity and population growth to fenland communities; locals counter-argued that their communities were already thriving. The detailed surviving records from early modern Whittlesey, in the Isle of Ely, are analysed here to test the accuracy of these opposing claims. Using the returns of the 1523 Lay Subsidy, the 1563 ecclesiastical census, the Lady Day 1674 Hearth Tax records and the 1676 Compton Census, together with bishops' transcripts and probate inventories, this article finds that although the population did indeed increase after drainage, the pre-drainage population was also increasing. The Michaelmas 1664 Hearth Tax records are analysed to uncover something of the character of the inhabitants and the 1674 Lady Day returns are then used to test the relative wealth of the community compared with that of sub-regions throughout England identified by Tom Arkell. Finally, there is a discussion of Whittlesey's housing stock.

  17. Recognising and Developing Urban Teachers: Chartered London Teacher Status

    ERIC Educational Resources Information Center

    Bubb, Sara; Porritt, Vivienne

    2008-01-01

    Chartered London Teacher (CLT) status is a unique scheme designed by London Challenge to recognise and reward teachers' achievements and provide a framework for professional development. As well as having the prestige of being a Chartered London Teacher for life, educators receive a one-time payment of 1,000 British pounds from the school budget…

  18. The Rhetoric of Bonds, Alliances, and Identities: Interrogating Social Networks in Early Modern English Drama

    ERIC Educational Resources Information Center

    Cady, Christina J.

    2010-01-01

    The household and family have received considerable interest in studies of early modern English drama, but less attention has been paid to how writers represent intimate affective bonds on the stage. Emotion is intangible; yet many writers convincingly convey the intensity of emotional bonds through rhetoric. Rhetoric is a mainstay in…

  19. Early Pleistocene third metacarpal from Kenya and the evolution of modern human-like hand morphology

    PubMed Central

    Ward, Carol V.; Tocheri, Matthew W.; Plavcan, J. Michael; Brown, Francis H.; Manthi, Fredrick Kyalo

    2014-01-01

    Despite discoveries of relatively complete hands from two early hominin species (Ardipithecus ramidus and Australopithecus sediba) and partial hands from another (Australopithecus afarensis), fundamental questions remain about the evolution of human-like hand anatomy and function. These questions are driven by the paucity of hand fossils in the hominin fossil record between 800,000 and 1.8 My old, a time interval well documented for the emergence and subsequent proliferation of Acheulian technology (shaped bifacial stone tools). Modern and Middle to Late Pleistocene humans share a suite of derived features in the thumb, wrist, and radial carpometacarpal joints that is noticeably absent in early hominins. Here we show that one of the most distinctive features of this suite in the Middle Pleistocene to recent human hand, the third metacarpal styloid process, was present ∼1.42 Mya in an East African hominin from Kaitio, West Turkana, Kenya. This fossil thus provides the earliest unambiguous evidence for the evolution of a key shared derived characteristic of modern human and Neandertal hand morphology and suggests that the distinctive complex of radial carpometacarpal joint features in the human hand arose early in the evolution of the genus Homo and probably in Homo erectus sensu lato. PMID:24344276

  20. Children's Physic: Medical Perceptions and Treatment of Sick Children in Early Modern England, c. 1580-1720.

    PubMed

    Newton, Hannah

    2010-12-01

    Historians of medicine, childhood and paediatrics have often assumed that early modern doctors neither treated children, nor adapted their medicines to suit the peculiar temperaments of the young. Through an examination of medical textbooks and doctors' casebooks, this article refutes these assumptions. It argues that medical authors and practising doctors regularly treated children, and were careful to tailor their remedies to complement the distinctive constitutions of children. Thus, this article proposes that a concept of 'children's physic' existed in early modern England. This term refers to the notion that children were physiologically distinct, requiring special medical care. Children's physic was rooted in the ancient traditions of Hippocratic and Galenic medicine: it was the child's humoral make-up that underpinned all medical ideas about children's bodies, minds, diseases and treatments. Children abounded in the humour blood, which made them humid and weak, and in need of medicines of a particularly gentle nature.

  1. Elementary Education and the Practices of Literacy in Catholic Girls' Schools in Early Modern Germany

    ERIC Educational Resources Information Center

    Rutz, Andreas

    2012-01-01

    Girls' schools in the early modern era were largely run by nuns and can therefore be distinguished as Catholic institutions of learning. These schools flourished in the Catholic parts of Europe since the turn of the seventeenth century. Despite their focus on religious education, elementary skills such as reading, writing and sometimes arithmetic…

  2. School Improvement in London: A Global Perspective

    ERIC Educational Resources Information Center

    McAleavy, Tony; Elwick, Alex

    2016-01-01

    This report considers how successful London's schools have been over the past decade and identifies potentially transferable components of the success story. There is much to be learned from the transformation undergone in London that is relevant to policymakers and educationalists worldwide, working in both high-income and low-income countries.…

  3. Teaching Exchange Rate Risk Using London's Gherkin Building: How Investors Were in (and out of) a Pickle

    ERIC Educational Resources Information Center

    Jones, Adam T.; Sackley, William H.; Watson, Ethan D.

    2017-01-01

    In this teaching note, the authors use an iconic London building, the Gherkin, as a motivation to understand exchange rates, cross exchange rates, and unhedged exchange rate risk. The famous tower was constructed in the early 2000s by Swiss Re, an insurance company, and then sold to investors as part of a sale-leaseback deal in early 2007.…

  4. Report of Charrette : re-connect New London 2010.

    DOT National Transportation Integrated Search

    2011-03-01

    "Members of Re-New London Council Board informally met with Dr. Norman Garrick in November 2009. A lively discussion regarding the : New London landscape in general and leverage points for revitalization ensued. Norman related his observations as he ...

  5. Report of Charrette re-connect New London 2010.

    DOT National Transportation Integrated Search

    2011-03-01

    Members of Re-New London Council Board informally met with Dr. Norman Garrick in November 2009. A lively discussion regarding the : New London landscape in general and leverage points for revitalization ensued. Norman related his observations as he e...

  6. 32. VIEW OF PHOTO CAPTIONED 'SUBMARINE BASE, NEW LONDON, CONN. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. VIEW OF PHOTO CAPTIONED 'SUBMARINE BASE, NEW LONDON, CONN. OCTOBER 3, 1932. COMPLETION OF ERECTION OF STEELWORK FOR ELEVATOR. LOOKING NORTH. CONTRACT NO. Y-1539-ELEVATOR, SUBMARINE ESCAPE TANK.' - U.S. Naval Submarine Base, New London Submarine Escape Training Tank, Albacore & Darter Roads, Groton, New London County, CT

  7. Early Cambrian origin of modern food webs: evidence from predator arrow worms.

    PubMed

    Vannier, J; Steiner, M; Renvoisé, E; Hu, S-X; Casanova, J-P

    2007-03-07

    Although palaeontological evidence from exceptional biota demonstrates the existence of diverse marine communities in the Early Cambrian (approx. 540-520 Myr ago), little is known concerning the functioning of the marine ecosystem, especially its trophic structure and the full range of ecological niches colonized by the fauna. The presence of a diverse zooplankton in Early Cambrian oceans is still an open issue. Here we provide compelling evidence that chaetognaths, an important element of modern zooplankton, were present in the Early Cambrian Chengjiang biota with morphologies almost identical to Recent forms. New information obtained from the lowermost Cambrian of China added to previous studies provide convincing evidence that protoconodont-bearing animals also belonged to chaetognaths. Chaetognaths were probably widespread and diverse in the earliest Cambrian. The obvious raptorial function of their circumoral apparatuses (grasping spines) places them among the earliest active predator metazoans. Morphology, body ratios and distribution suggest that the ancestral chaetognaths were planktonic with possible ecological preferences for hyperbenthic niches close to the sea bottom. Our results point to the early introduction of prey-predator relationships into the pelagic realm, and to the increase of trophic complexity (three-level structure) during the Precambrian-Cambrian transition, thus laying the foundations of present-day marine food chains.

  8. Early Cambrian origin of modern food webs: evidence from predator arrow worms

    PubMed Central

    Vannier, J; Steiner, M; Renvoisé, E; Hu, S.-X; Casanova, J.-P

    2006-01-01

    Although palaeontological evidence from exceptional biota demonstrates the existence of diverse marine communities in the Early Cambrian (approx. 540–520 Myr ago), little is known concerning the functioning of the marine ecosystem, especially its trophic structure and the full range of ecological niches colonized by the fauna. The presence of a diverse zooplankton in Early Cambrian oceans is still an open issue. Here we provide compelling evidence that chaetognaths, an important element of modern zooplankton, were present in the Early Cambrian Chengjiang biota with morphologies almost identical to Recent forms. New information obtained from the lowermost Cambrian of China added to previous studies provide convincing evidence that protoconodont-bearing animals also belonged to chaetognaths. Chaetognaths were probably widespread and diverse in the earliest Cambrian. The obvious raptorial function of their circumoral apparatuses (grasping spines) places them among the earliest active predator metazoans. Morphology, body ratios and distribution suggest that the ancestral chaetognaths were planktonic with possible ecological preferences for hyperbenthic niches close to the sea bottom. Our results point to the early introduction of prey–predator relationships into the pelagic realm, and to the increase of trophic complexity (three-level structure) during the Precambrian–Cambrian transition, thus laying the foundations of present-day marine food chains. PMID:17254986

  9. Volcanic ash layers illuminate the resilience of Neanderthals and early modern humans to natural hazards

    PubMed Central

    Lowe, John; Barton, Nick; Blockley, Simon; Ramsey, Christopher Bronk; Cullen, Victoria L.; Davies, William; Gamble, Clive; Grant, Katharine; Hardiman, Mark; Housley, Rupert; Lane, Christine S.; Lee, Sharen; Lewis, Mark; MacLeod, Alison; Menzies, Martin; Müller, Wolfgang; Pollard, Mark; Price, Catherine; Roberts, Andrew P.; Rohling, Eelco J.; Satow, Chris; Smith, Victoria C.; Stringer, Chris B.; Tomlinson, Emma L.; White, Dustin; Albert, Paul; Arienzo, Ilenia; Barker, Graeme; Borić, Dušan; Carandente, Antonio; Civetta, Lucia; Ferrier, Catherine; Guadelli, Jean-Luc; Karkanas, Panagiotis; Koumouzelis, Margarita; Müller, Ulrich C.; Orsi, Giovanni; Pross, Jörg; Rosi, Mauro; Shalamanov-Korobar, Ljiljiana; Sirakov, Nikolay; Tzedakis, Polychronis C.

    2012-01-01

    Marked changes in human dispersal and development during the Middle to Upper Paleolithic transition have been attributed to massive volcanic eruption and/or severe climatic deterioration. We test this concept using records of volcanic ash layers of the Campanian Ignimbrite eruption dated to ca. 40,000 y ago (40 ka B.P.). The distribution of the Campanian Ignimbrite has been enhanced by the discovery of cryptotephra deposits (volcanic ash layers that are not visible to the naked eye) in archaeological cave sequences. They enable us to synchronize archaeological and paleoclimatic records through the period of transition from Neanderthal to the earliest anatomically modern human populations in Europe. Our results confirm that the combined effects of a major volcanic eruption and severe climatic cooling failed to have lasting impacts on Neanderthals or early modern humans in Europe. We infer that modern humans proved a greater competitive threat to indigenous populations than natural disasters. PMID:22826222

  10. Volcanic ash layers illuminate the resilience of Neanderthals and early modern humans to natural hazards.

    PubMed

    Lowe, John; Barton, Nick; Blockley, Simon; Ramsey, Christopher Bronk; Cullen, Victoria L; Davies, William; Gamble, Clive; Grant, Katharine; Hardiman, Mark; Housley, Rupert; Lane, Christine S; Lee, Sharen; Lewis, Mark; MacLeod, Alison; Menzies, Martin; Müller, Wolfgang; Pollard, Mark; Price, Catherine; Roberts, Andrew P; Rohling, Eelco J; Satow, Chris; Smith, Victoria C; Stringer, Chris B; Tomlinson, Emma L; White, Dustin; Albert, Paul; Arienzo, Ilenia; Barker, Graeme; Boric, Dusan; Carandente, Antonio; Civetta, Lucia; Ferrier, Catherine; Guadelli, Jean-Luc; Karkanas, Panagiotis; Koumouzelis, Margarita; Müller, Ulrich C; Orsi, Giovanni; Pross, Jörg; Rosi, Mauro; Shalamanov-Korobar, Ljiljiana; Sirakov, Nikolay; Tzedakis, Polychronis C

    2012-08-21

    Marked changes in human dispersal and development during the Middle to Upper Paleolithic transition have been attributed to massive volcanic eruption and/or severe climatic deterioration. We test this concept using records of volcanic ash layers of the Campanian Ignimbrite eruption dated to ca. 40,000 y ago (40 ka B.P.). The distribution of the Campanian Ignimbrite has been enhanced by the discovery of cryptotephra deposits (volcanic ash layers that are not visible to the naked eye) in archaeological cave sequences. They enable us to synchronize archaeological and paleoclimatic records through the period of transition from Neanderthal to the earliest anatomically modern human populations in Europe. Our results confirm that the combined effects of a major volcanic eruption and severe climatic cooling failed to have lasting impacts on Neanderthals or early modern humans in Europe. We infer that modern humans proved a greater competitive threat to indigenous populations than natural disasters.

  11. Taylor Elected to Royal Society of London

    Science.gov Websites

    SLAC, 28 May 1997 Taylor Elected to Royal Society of London Richard Taylor, physics professor at statements must be verified by facts. Taylor will travel to London in the near future for his induction, part Isaac Newton and Michael Faraday. Taylor, a Canadian citizen, received his Ph.D. at Stanford in 1962 and

  12. Metaphors and images of cancer in early modern Europe.

    PubMed

    Stolberg, Michael

    2014-01-01

    Drawing on learned medical writing about cancer and on nonmedical texts that used cancer as a metaphor for hateful cultural, social, religious, or political phenomena that warranted drastic measures, this article traces the metaphors and images that framed the perception and experience of cancer in the early modern period. It finds that cancer was closely associated with notions of impurity and a visible destruction of the body's surface and was diagnosed primarily in women, as breast and uterine cancer. Putrid, corrosive cancerous humor was thought not only to accumulate and eat its way into the surrounding flesh but also to spread, like the seeds of a plant, "infecting" the whole body. This infectious quality, the putrid secretions, and the often horrendous smell emanating from cancer victims raised fears, in turn, of contagion and were taken to justify a separation of cancer patients from the rest of society.

  13. 30. VIEW OF PHOTO CAPTIONED 'SUBMARINE BASE, NEW LONDON, CONNECTICUT. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. VIEW OF PHOTO CAPTIONED 'SUBMARINE BASE, NEW LONDON, CONNECTICUT. 2 JUNE 1930. SUBMARINE TRAINING TANK - STEELWORK 98% COMPLETE; BRICKWORK 95% COMPLETE, PIPING 10% IN PLACE. LOOKING NORTH. CONTRACT NO. Y-1539-ELEVATOR, SUBMARINE ESCAPE TANK.' - U.S. Naval Submarine Base, New London Submarine Escape Training Tank, Albacore & Darter Roads, Groton, New London County, CT

  14. Tracing sexual identities in "old age": gender and seniority in advice literature of the early-modern and modern periods.

    PubMed

    van Tilburg, Marja

    2009-10-01

    Thus far, historians have interpreted representations of elderly women with reference to women's roles or to women's positions in society. This article proposes a different approach toward gender: to relate representations of the aged to the sexual identities of both men and women. This article analyzes representations of old age in conduct books of the early-modern period and the nineteenth century. By drawing a comparison, the eighteenth-century change of "identity regime" in European culture is brought to the fore. The article points to the influence of sexual identities on the representations of senior persons in advice literature both in Dutch and translated into Dutch.

  15. Promoting free flow in the networks: Reimagining the body in early modern Suzhou.

    PubMed

    Scheid, Volker

    2017-06-01

    The history of Chinese medicine is still widely imagined in terms dictated by the discourse of modernity, that is as 'traditional' and 'Chinese.' And yet, so as to be intelligible to us moderns, it must simultaneously be framed through categories that make it comparable somehow to the 'West' and the 'modern' from which it is said to be essentially different. This is accomplished, for instance, by viewing Chinese medicine as fundamentally shaped by cosmological thinking, as focusing on process rather than matter, and as forever hampered by attachments to the past even when it tries to innovate. At the same time, it is described as pursuing its objectives in ways that make sense in 'our' terms, too, such as the goal of creating physiological homeostasis through methods of supplementation and drainage. In this paper, I seek to move beyond this kind of analysis through a two-pronged approach. First, by focusing on the concept of tong - a character that calls forth images of free flow, connectivity, relatedness and understanding - I foreground an important aspect of Chinese medical thinking and practice that has virtually been ignored by Western historians of medicine and science. Second, by exploring how the influential physician Ye Tianshi (1664-1746) employed tong to advance medical thinking and practice at a crucial moment of change in the history of Chinese medicine, I demonstrate that physicians in early modern China moved towards new understandings of the body readily intelligible by modern biomedical anatomy. I argue that this mode of analysis allows us to transcend the limitations inherent in the current historiography of Chinese medicine: because it allows for comparison to emerge from our subject matter rather than imposing our imaginaries onto it in advance.

  16. Study of 100 patients injured by London underground trains 1981-6.

    PubMed

    Cocks, R A

    1987-12-12

    One hundred patients who were injured by London underground trains during 1981-6 were studied; 43 of them died. Deliberate self harm was probable in roughly three quarters. Alcohol intoxication was thought to play an important part in a further tenth of cases. Thirteen were psychiatric inpatients at the time of the incident, and a further two had recently been discharged. Early warning of a potential suicide attempt was given during the 24 hours preceding the incident in 15 of the cases. Some of the deaths in the psychiatric patients may have been preventable.

  17. Air pollution dispersion models for human exposure predictions in London.

    PubMed

    Beevers, Sean D; Kitwiroon, Nutthida; Williams, Martin L; Kelly, Frank J; Ross Anderson, H; Carslaw, David C

    2013-01-01

    The London household survey has shown that people travel and are exposed to air pollutants differently. This argues for human exposure to be based upon space-time-activity data and spatio-temporal air quality predictions. For the latter, we have demonstrated the role that dispersion models can play by using two complimentary models, KCLurban, which gives source apportionment information, and Community Multi-scale Air Quality Model (CMAQ)-urban, which predicts hourly air quality. The KCLurban model is in close agreement with observations of NO(X), NO(2) and particulate matter (PM)(10/2.5), having a small normalised mean bias (-6% to 4%) and a large Index of Agreement (0.71-0.88). The temporal trends of NO(X) from the CMAQ-urban model are also in reasonable agreement with observations. Spatially, NO(2) predictions show that within 10's of metres of major roads, concentrations can range from approximately 10-20 p.p.b. up to 70 p.p.b. and that for PM(10/2.5) central London roadside concentrations are approximately double the suburban background concentrations. Exposure to different PM sources is important and we predict that brake wear-related PM(10) concentrations are approximately eight times greater near major roads than at suburban background locations. Temporally, we have shown that average NO(X) concentrations close to roads can range by a factor of approximately six between the early morning minimum and morning rush hour maximum periods. These results present strong arguments for the hybrid exposure model under development at King's and, in future, for in-building models and a model for the London Underground.

  18. Wombs, Worms and Wolves: Constructing Cancer in Early Modern England.

    PubMed

    Skuse, Alanna

    2014-11-01

    This essay examines medical and popular attitudes to cancer in the early modern period, c .1580-1720. Cancer, it is argued, was understood as a cruel and usually incurable disease, diagnosable by a well-defined set of symptoms understood to correspond to its etymological root, karkinos (the crab). It was primarily understood as produced by an imbalance of the humours, with women being particularly vulnerable. However, such explanations proved inadequate to make sense of the condition's malignancy, and medical writers frequently constructed cancer as quasi-sentient, zoomorphising the disease as an eating worm or wolf. In turn, these constructions materially influenced medical practice, in which practitioners swung between anxiety over 'aggravating' the disease and an adversarial approach which fostered the use of radical and dangerous 'cures' including caustics and surgery.

  19. Wombs, Worms and Wolves: Constructing Cancer in Early Modern England

    PubMed Central

    Skuse, Alanna

    2014-01-01

    This essay examines medical and popular attitudes to cancer in the early modern period, c.1580–1720. Cancer, it is argued, was understood as a cruel and usually incurable disease, diagnosable by a well-defined set of symptoms understood to correspond to its etymological root, karkinos (the crab). It was primarily understood as produced by an imbalance of the humours, with women being particularly vulnerable. However, such explanations proved inadequate to make sense of the condition's malignancy, and medical writers frequently constructed cancer as quasi-sentient, zoomorphising the disease as an eating worm or wolf. In turn, these constructions materially influenced medical practice, in which practitioners swung between anxiety over ‘aggravating’ the disease and an adversarial approach which fostered the use of radical and dangerous ‘cures’ including caustics and surgery. PMID:25352720

  20. A nearly modern amphibious bird from the Early Cretaceous of northwestern China.

    PubMed

    You, Hai-Lu; Lamanna, Matthew C; Harris, Jerald D; Chiappe, Luis M; O'connor, Jingmai; Ji, Shu-An; Lü, Jun-Chang; Yuan, Chong-Xi; Li, Da-Qing; Zhang, Xing; Lacovara, Kenneth J; Dodson, Peter; Ji, Qiang

    2006-06-16

    Three-dimensional specimens of the volant fossil bird Gansus yumenensis from the Early Cretaceous Xiagou Formation of northwestern China demonstrate that this taxon possesses advanced anatomical features previously known only in Late Cretaceous and Cenozoic ornithuran birds. Phylogenetic analysis recovers Gansus within the Ornithurae, making it the oldest known member of the clade. The Xiagou Formation preserves the oldest known ornithuromorph-dominated avian assemblage. The anatomy of Gansus, like that of other non-neornithean (nonmodern) ornithuran birds, indicates specialization for an amphibious life-style, supporting the hypothesis that modern birds originated in aquatic or littoral niches.

  1. Experiential Approaches to the Global City: London as Social Laboratory

    ERIC Educational Resources Information Center

    Gristwood, Anthony; Woolf, Michael

    2011-01-01

    London is the paramount example of a city that is not bounded by its geography and cannot be grasped in isolation. The U.K.'s national capital and the prime focus for business, finance and creative industries, London also transcends the U.K.'s borders as a hub of the world economy. This paper argues that London, a city riddled by the socioeconomic…

  2. Early Pliocene onset of modern Nordic Seas circulation related to ocean gateway changes.

    PubMed

    De Schepper, Stijn; Schreck, Michael; Beck, Kristina Marie; Matthiessen, Jens; Fahl, Kirsten; Mangerud, Gunn

    2015-10-28

    The globally warm climate of the early Pliocene gradually cooled from 4 million years ago, synchronous with decreasing atmospheric CO2 concentrations. In contrast, palaeoceanographic records indicate that the Nordic Seas cooled during the earliest Pliocene, before global cooling. However, a lack of knowledge regarding the precise timing of Nordic Seas cooling has limited our understanding of the governing mechanisms. Here, using marine palynology, we show that cooling in the Nordic Seas was coincident with the first trans-Arctic migration of cool-water Pacific mollusks around 4.5 million years ago, and followed by the development of a modern-like Nordic Seas surface circulation. Nordic Seas cooling precedes global cooling by 500,000 years; as such, we propose that reconfiguration of the Bering Strait and Central American Seaway triggered the development of a modern circulation in the Nordic Seas, which is essential for North Atlantic Deep Water formation and a precursor for more widespread Greenland glaciation in the late Pliocene.

  3. Suicide on the London Underground System.

    PubMed

    Farmer, R; O'Donnell, I; Tranah, T

    1991-09-01

    Over the past 50 years there has been an increase in the numbers of people jumping/falling in front of trains on the London Underground system. Case-fatality rates have fallen from 70% in the 1950s to 55% today. The proportion certified as suicide has fallen while the proportions certified as accidents or open verdicts have risen. There is unusual clustering of events at some stations which are adjacent to psychiatric units. The hypothesis that ease of access to London Underground stations may sometimes be a determinant of suicide is investigated.

  4. Community Engagement using World Café: The Well London Experience

    PubMed Central

    Sheridan, Kevin; Adams-Eaton, Faye; Trimble, Allison; Renton, Adrian; Bertotti, Marcello

    2016-01-01

    The Well London programme was launched across twenty boroughs in London during late 2007 to improve the health and well-being of residents living in some of the most deprived communities in London. Well London employed a multi-stage community engagement process which informed the overall project strategy for each intervention area. In this article we establish and describe the key principles that guided the design of this innovative community engagement process. Principles included building collaborative partnerships, working with whole-systems, privileging community knowledge and working with the deficit of experience in each area. The article then describes in detail how these principles were operationalised throughout the preparation and delivery of forty World Cafes, which were the first open community activities of the Well London community engagement process. Finally, this article reflects on and summarises the lessons learned when employing innovative, inclusive and transparent community engagement for health promotion. PMID:27857453

  5. Community Engagement using World Café: The Well London Experience.

    PubMed

    Sheridan, Kevin; Adams-Eaton, Faye; Trimble, Allison; Renton, Adrian; Bertotti, Marcello

    2010-01-01

    The Well London programme was launched across twenty boroughs in London during late 2007 to improve the health and well-being of residents living in some of the most deprived communities in London. Well London employed a multi-stage community engagement process which informed the overall project strategy for each intervention area. In this article we establish and describe the key principles that guided the design of this innovative community engagement process. Principles included building collaborative partnerships, working with whole-systems, privileging community knowledge and working with the deficit of experience in each area. The article then describes in detail how these principles were operationalised throughout the preparation and delivery of forty World Cafes, which were the first open community activities of the Well London community engagement process. Finally, this article reflects on and summarises the lessons learned when employing innovative, inclusive and transparent community engagement for health promotion.

  6. The Struggle to Study. Financial Implications for Adults Studying in London. A Research Report Funded by London's Four Open College Networks: ALFA, CAWLOC, GLEAN, and OCSL.

    ERIC Educational Resources Information Center

    Sims, Anne; Goddard, Ty

    The four Open College Networks in London assessed the climate in inner London for adult students who wished to return to education and training. The research focussed on: the extent to which recent legislative changes threatened adult participation in education and training; the abolition of the Inner London Education Authority (ILEA) and…

  7. Changing the Subject: English in London, 1945-1967

    ERIC Educational Resources Information Center

    Yandell, John

    2014-01-01

    Two recent books, "English Teachers in a Postwar Democracy: Emerging Choice in London Schools, 1945-1965" and "The London Association for the Teaching of English, 1947-67: A History," explore an important period in the development of English as a school subject and in the remaking of the professional identity of English…

  8. Shutt up: bubonic plague and quarantine in early modern England.

    PubMed

    Newman, Kira L S

    2012-01-01

    The outbreak of bubonic plague that struck London and Westminster in 1636 provoked the usual frenzied response to epidemics, including popular flight and government-mandated quarantine. The government asserted that plague control measures were acts of public health for the benefit of all. However, contrary to this government narrative of disease prevention there was a popular account that portrayed quarantine and isolation as personal punishment rather than prudent policy. In examining the 1636 outbreak on the parish as well as the individual level, reasons for this inconsistency between official and unofficial perspectives emerge. Quarantine and its effects were not classless, and its implementation was not always strictly in the name of public health. Government application of quarantine was remarkably effective, but it could never be uncontroversial both because of circumstances and because of misuse. The flight of the wealthiest from London and Westminster left only the more socially vulnerable to be quarantined. Though plague policy was financially sensitive to the poorest, it was costly to the middling sort. Another cause of controversy was the government's use of quarantine as a punishment to control individuals found breaking other laws. Though not widely publicized, popular narratives continually included grievances about the cruelty and inequity of quarantine and the militaristic nature of its implementation. Despite these objections, quarantine remained a staple of the government response to plague outbreaks throughout the seventeenth century.

  9. Conjugal intimacy, gender and modernity in contemporary China.

    PubMed

    Liu, Jieyu; Bell, Eona; Zhang, Jiayu

    2017-12-15

    The new generation of modernity theorists have forecast the democratization of gender relations within intimate relationships in late-modern times. Chinese society has undergone rapid and dramatic changes in its unique trajectory of political, social and economic reform. Using China as an example of a region which has been largely ignored in contemporary social theory, this article enters the debate to contest the extent to which conjugal relationships are democratized in line with modernity. We further test the assertion that modern marriages are characterized by increased self-disclosure and communication between partners. Data from a national survey on Chinese families is analysed in relation to the level of self-disclosure between husbands and wives; gender division of housework; household decision-making; and home ownership. We highlight the impact of gender, cohort and location (urban, rural or migrant) on experiences of modernity and draw attention to the material, social and cultural factors which continue to shape conjugal relations in contemporary Chinese society. Based on our findings, we contest the argument that disclosing intimacy between intimate partners is a defining characteristic of modern relationships, and suggest that other social factors may condition degrees of self-disclosure in marriage. Similarly, we question the extent to which heterosexual conjugal equality is attained: the cultural practices and values of patrilineal family organization, together with material circumstances, continue to influence marital relations in China. © London School of Economics and Political Science 2017.

  10. Book review: Mapping gendered routes and spaces in the early modern world

    USGS Publications Warehouse

    Varanka, Dalia E.

    2016-01-01

    This book encapsulates and extends many seminal ideas presented at the eighth “Attending to Early Modern Women” conference held at the University of Wisconsin–Milwaukee in June 2012. Merry Wiesner-Hanks has done a masterful job editing these papers within a central theme of the interaction of spatial domains with gender-based phenomena. The fifteen chapters of this book are organized into four sections: “Framework,” discussing theoretical concepts; “Embodied Environments,” focusing on physicality; “Communities and Networks” of social patterns; and “Exchanges” across geographic space. Together, a global society shaped by gender and sexuality and intersected by race and class emerges.

  11. Study of 100 patients injured by London underground trains 1981-6.

    PubMed Central

    Cocks, R A

    1987-01-01

    One hundred patients who were injured by London underground trains during 1981-6 were studied; 43 of them died. Deliberate self harm was probable in roughly three quarters. Alcohol intoxication was thought to play an important part in a further tenth of cases. Thirteen were psychiatric inpatients at the time of the incident, and a further two had recently been discharged. Early warning of a potential suicide attempt was given during the 24 hours preceding the incident in 15 of the cases. Some of the deaths in the psychiatric patients may have been preventable. PMID:3122889

  12. Teaching the History of Astronomy On Site in London

    NASA Astrophysics Data System (ADS)

    French, Linda M.

    2016-01-01

    In the autumn of 2014, the author had the opportunity to teach a class on the history of astronomy in England as part of a study abroad experience for students at Illinois Wesleyan University. The philosophy of the program is to use the rich cultural environment of London as a setting for active learning. In the classroom, students read and discussed selected works by Ptolemy, Copernicus, Kepler, Galileo, and Herschel. We visited Stonehenge, the Royal Greenwich Observatory, the London Science Museum, the London Monument, and the library of the Royal Astronomical Society. Lessons learned from the experience will be shared.

  13. Review essay: empires, ancient and modern.

    PubMed

    Hall, John A

    2011-09-01

    This essay drews attention to two books on empires by historians which deserve the attention of sociologists. Bang's model of the workings of the Roman economy powerfully demonstrates the tributary nature of per-industrial tributary empires. Darwin's analysis concentrates on modern overseas empires, wholly different in character as they involved the transportation of consumption items for the many rather than luxury goods for the few. Darwin is especially good at describing the conditions of existence of late nineteenth century empires, noting that their demise was caused most of all by the failure of balance of power politics in Europe. Concluding thoughts are offered about the USA. © London School of Economics and Political Science 2011.

  14. Floods of the Maros river in the early modern and modern period (16th-20th centuries)

    NASA Astrophysics Data System (ADS)

    Kiss, Andrea

    2016-04-01

    In the poster presentation a series of historical and recent floods of the Maros river, with special emphasis on the flood events occurred on the lower sections, are presented. Similar to the Hungarian flood databases of the Middle-Danube and Lower-Tisza, the main sources of investigations are the institutional (legal-administrative) documentary evidence (e.g. Szeged and Makó town council protocols and related administrative documentation, Csanád County meeting protocols) mainly from the late 17th-early 18th century onwards. However, in case of the Maros river there is an increased importance of narrative sources, with special emphasis on the early modern period (16th-17th century): in this case the (mainly Transylvanian) narratives (chronicles, diaries, memoires etc.) written by aristocrats, other noblemen and town citizens have particular importance. In the presentation the frequency of detected flood events, from the mid-16th century onwards (with an outlook on sporadic medieval evidence), is provided; moreover, a 3-scaled magnitude classification and a seasonality analysis are also presented. Floods of the Maros river, especially those of the lower river sections, often cannot be understood and discussed without the floods of the (Lower-)Tisza; thus, a comparison of the two flood series are also a subject of discussion. Unlike the Lower-Tisza, the Maros is prone to winter and early spring ice jam floods: since the floods that belonged to this type (similar to those of the Middle-Danube at Budapest) were the most destructive among the flood events of the river, this flood type, and the greatest flood events (e.g. 1751-1752, 1784) are also presented in more detail.

  15. [John Snow, the cholera epidemic and the foundation of modern epidemiology].

    PubMed

    Cerda L, Jaime; Valdivia C, Gonzalo

    2007-08-01

    John Snow (1813-1858) was a brilliant British physician. Since young he stood out for his acute observation capacity, logical thinking and perseverance, first in anesthetics and later in epidemiology. The successive outbreaks of cholera that affected London, motivated him to study this disease from a populational point of view. He related the appearance of cases to the consumption of "morbid matter", responsible for the acute diarrhea with dehydration that characterizes this disease. Bravely, Snow opposed to certain theories present at his time, sacrificing his own prestige. He was a pioneer in the use of modern epidemiological investigation methodologies such as conducting surveys and spatial epidemiology. Fairly, he is considered nowadays as father of modern epidemiology by the scientific community.

  16. Unexpected Early Triassic marine ecosystem and the rise of the Modern evolutionary fauna

    PubMed Central

    Brayard, Arnaud; Krumenacker, L. J.; Botting, Joseph P.; Jenks, James F.; Bylund, Kevin G.; Fara, Emmanuel; Vennin, Emmanuelle; Olivier, Nicolas; Goudemand, Nicolas; Saucède, Thomas; Charbonnier, Sylvain; Romano, Carlo; Doguzhaeva, Larisa; Thuy, Ben; Hautmann, Michael; Stephen, Daniel A.; Thomazo, Christophe; Escarguel, Gilles

    2017-01-01

    In the wake of the end-Permian mass extinction, the Early Triassic (~251.9 to 247 million years ago) is portrayed as an environmentally unstable interval characterized by several biotic crises and heavily depauperate marine benthic ecosystems. We describe a new fossil assemblage—the Paris Biota—from the earliest Spathian (middle Olenekian, ~250.6 million years ago) of the Bear Lake area, southeastern Idaho, USA. This highly diversified assemblage documents a remarkably complex marine ecosystem including at least seven phyla and 20 distinct metazoan orders, along with algae. Most unexpectedly, it combines early Paleozoic and middle Mesozoic taxa previously unknown from the Triassic strata, among which are primitive Cambrian-Ordovician leptomitid sponges (a 200–million year Lazarus taxon) and gladius-bearing coleoid cephalopods, a poorly documented group before the Jurassic (~50 million years after the Early Triassic). Additionally, the crinoid and ophiuroid specimens show derived anatomical characters that were thought to have evolved much later. Unlike previous works that suggested a sluggish postcrisis recovery and a low diversity for the Early Triassic benthic organisms, the unexpected composition of this exceptional assemblage points toward an early and rapid post-Permian diversification for these clades. Overall, it illustrates a phylogenetically diverse, functionally complex, and trophically multileveled marine ecosystem, from primary producers up to top predators and potential scavengers. Hence, the Paris Biota highlights the key evolutionary position of Early Triassic fossil ecosystems in the transition from the Paleozoic to the Modern marine evolutionary fauna at the dawn of the Mesozoic era. PMID:28246643

  17. Unexpected Early Triassic marine ecosystem and the rise of the Modern evolutionary fauna.

    PubMed

    Brayard, Arnaud; Krumenacker, L J; Botting, Joseph P; Jenks, James F; Bylund, Kevin G; Fara, Emmanuel; Vennin, Emmanuelle; Olivier, Nicolas; Goudemand, Nicolas; Saucède, Thomas; Charbonnier, Sylvain; Romano, Carlo; Doguzhaeva, Larisa; Thuy, Ben; Hautmann, Michael; Stephen, Daniel A; Thomazo, Christophe; Escarguel, Gilles

    2017-02-01

    In the wake of the end-Permian mass extinction, the Early Triassic (~251.9 to 247 million years ago) is portrayed as an environmentally unstable interval characterized by several biotic crises and heavily depauperate marine benthic ecosystems. We describe a new fossil assemblage-the Paris Biota-from the earliest Spathian (middle Olenekian, ~250.6 million years ago) of the Bear Lake area, southeastern Idaho, USA. This highly diversified assemblage documents a remarkably complex marine ecosystem including at least seven phyla and 20 distinct metazoan orders, along with algae. Most unexpectedly, it combines early Paleozoic and middle Mesozoic taxa previously unknown from the Triassic strata, among which are primitive Cambrian-Ordovician leptomitid sponges (a 200-million year Lazarus taxon) and gladius-bearing coleoid cephalopods, a poorly documented group before the Jurassic (~50 million years after the Early Triassic). Additionally, the crinoid and ophiuroid specimens show derived anatomical characters that were thought to have evolved much later. Unlike previous works that suggested a sluggish postcrisis recovery and a low diversity for the Early Triassic benthic organisms, the unexpected composition of this exceptional assemblage points toward an early and rapid post-Permian diversification for these clades. Overall, it illustrates a phylogenetically diverse, functionally complex, and trophically multileveled marine ecosystem, from primary producers up to top predators and potential scavengers. Hence, the Paris Biota highlights the key evolutionary position of Early Triassic fossil ecosystems in the transition from the Paleozoic to the Modern marine evolutionary fauna at the dawn of the Mesozoic era.

  18. Police deaths in New York and London during the twentieth century

    PubMed Central

    Kyriacou, D N; Monkkonen, E H; Peek‐Asa, C; Lucke, R E; Labbett, S; Pearlman, K S; Hutson, H R

    2006-01-01

    Objectives To describe the incidences and causes of occupational police deaths in New York City in the United States and Greater London in the United Kingdom during the twentieth century. To assess the relation between overall societal violence and violence directed toward police officers in these metropolitan areas. Design and setting Ecological study of New York and London from 1900 through 1999. Main outcome measures Intentional and unintentional occupational police mortality rates for New York and London were estimated for each decade. The general population homicide rates of both New York and London were assessed for their correlation with their respective intentional occupational police mortality rates. Results During the 20th century, 585 police officers in New York and 160 police officers in London died while participating in law enforcement activities. New York had markedly greater intentional police mortality rates compared to London throughout most of the 20th century, but these differences decreased significantly by the end of the century. Intentional gunshot wounds comprised 290 police deaths in New York, but only 14 police deaths in London. In New York, gun shot wounds (both intentional and unintentional) accounted for more occupational police deaths (51.6%) than did all other injury mechanisms combined. In London, motor vehicle collision was the most common cause (47.5%) of occupational police death. There were no apparent correlations between the general population homicide rates and intentional police mortality rates in either New York (r2 = 0.05, 95% CI −0.77 to 0.81) or London (r2 = 0.34, 95% CI −0.61 to 0.89). Conclusions During the 20th century, both intentional and unintentional occupational police mortality rates were significantly greater in New York compared to London. These differences are likely from several socioeconomic, cultural, and occupational factors. The declines in police deaths in New York during the latter part of

  19. Digital London: Creating a Searchable Web of Interlinked Sources on Eighteenth Century London

    ERIC Educational Resources Information Center

    Shoemaker, Robert

    2005-01-01

    Purpose: To outline the conceptual and technical difficulties encountered, as well as the opportunities created, when developing an interlinked collection of web-based digitised primary sources on eighteenth century London. Design/methodology/approach: As a pilot study for a larger project, a variety of primary sources, including the "Old…

  20. Children’s Physic: Medical Perceptions and Treatment of Sick Children in Early Modern England, c. 1580–1720

    PubMed Central

    Newton, Hannah

    2015-01-01

    Summary Historians of medicine, childhood and paediatrics have often assumed that early modern doctors neither treated children, nor adapted their medicines to suit the peculiar temperaments of the young. Through an examination of medical textbooks and doctors’ casebooks, this article refutes these assumptions. It argues that medical authors and practising doctors regularly treated children, and were careful to tailor their remedies to complement the distinctive constitutions of children. Thus, this article proposes that a concept of ‘children’s physic’ existed in early modern England. This term refers to the notion that children were physiologically distinct, requiring special medical care. Children’s physic was rooted in the ancient traditions of Hippocratic and Galenic medicine: it was the child’s humoral make-up that underpinned all medical ideas about children’s bodies, minds, diseases and treatments. Children abounded in the humour blood, which made them humid and weak, and in need of medicines of a particularly gentle nature. PMID:26306061

  1. Historical DNA reveals the demographic history of Atlantic cod (Gadus morhua) in medieval and early modern Iceland

    PubMed Central

    Ólafsdóttir, Guðbjörg Ásta; Westfall, Kristen M.; Edvardsson, Ragnar; Pálsson, Snæbjörn

    2014-01-01

    Atlantic cod (Gadus morhua) vertebrae from archaeological sites were used to study the history of the Icelandic Atlantic cod population in the time period of 1500–1990. Specifically, we used coalescence modelling to estimate population size and fluctuations from the sequence diversity at the cytochrome b (cytb) and Pantophysin I (PanI) loci. The models are consistent with an expanding population during the warm medieval period, large historical effective population size (NE), a marked bottleneck event at 1400–1500 and a decrease in NE in early modern times. The model results are corroborated by the reduction of haplotype and nucleotide variation over time and pairwise population distance as a significant portion of nucleotide variation partitioned across the 1550 time mark. The mean age of the historical fished stock is high in medieval times with a truncation in age in early modern times. The population size crash coincides with a period of known cooling in the North Atlantic, and we conclude that the collapse may be related to climate or climate-induced ecosystem change. PMID:24403343

  2. Historical DNA reveals the demographic history of Atlantic cod (Gadus morhua) in medieval and early modern Iceland.

    PubMed

    Ólafsdóttir, Guðbjörg Ásta; Westfall, Kristen M; Edvardsson, Ragnar; Pálsson, Snæbjörn

    2014-02-22

    Atlantic cod (Gadus morhua) vertebrae from archaeological sites were used to study the history of the Icelandic Atlantic cod population in the time period of 1500-1990. Specifically, we used coalescence modelling to estimate population size and fluctuations from the sequence diversity at the cytochrome b (cytb) and Pantophysin I (PanI) loci. The models are consistent with an expanding population during the warm medieval period, large historical effective population size (NE), a marked bottleneck event at 1400-1500 and a decrease in NE in early modern times. The model results are corroborated by the reduction of haplotype and nucleotide variation over time and pairwise population distance as a significant portion of nucleotide variation partitioned across the 1550 time mark. The mean age of the historical fished stock is high in medieval times with a truncation in age in early modern times. The population size crash coincides with a period of known cooling in the North Atlantic, and we conclude that the collapse may be related to climate or climate-induced ecosystem change.

  3. The Influence of Green Infrastructure on Urban Resilience in Greater London

    NASA Astrophysics Data System (ADS)

    Oh, Yukyung

    2017-04-01

    High population densities and diverse economic activities in urban areas create social issues as well as a range of environmental impacts including air pollution, soil contamination, loss of biodiversity and health problems (Alberti et al., 2003; Dobbs, Escobedo, & Zipperer, 2011; Grimm et al., 2008). The concept of urban resilience has been used for increasing the capacity of the entities and players to adapt to rapid changes, and urban green spaces play a crucial role in increasing urban resilience. Greater London has a good case for increasing urban green spaces and resilience under the London Plan. The relevance of urban open spaces and several socioeconomic indicators would provide researchers and policy makers with the information for managing green coverage. The correlation analysis of two quantitative data such as open space and socioeconomic data of Greater London was conducted with SPSS. The data for open spaces in Greater London was gained through Greenspace Information for Greater London. The data was converted from vector to raster in Geographic Information System (GIS), so as to calculate landscape metrics for open spaces in Greater London through a spatial pattern analysis program, FRAGSTATS 4.2. The socioeconomic data was obtained from "London Borough Profile", London Datastore. In addition, data on total carbon emissions from Industry and Commercial, Domestic, Transport, LULUCF Net Emissions, and per capita emissions were gained from UK local authority and regional carbon dioxide emissions national statistics: 2005-2014 released from Department of Energy and Climate Change. The indicators from open spaces are total area of open space and patch density or contagion of open spaces. The latter indicator allows to figure out the level of fragmentation of open spaces. The socioeconomic indicators cover number of jobs by workplace, jobs density, crime rates per thousand population, and several wellbeing indicators such as life satisfaction

  4. Clean Air for London (CLEARFLO) Final Campaign Summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Worsnop, D. R.; Williams, L. R.; Herndon, S. C.

    This field campaign funded the participation of scientists from seven different research groups and operated over thirty instruments during the Winter Intensive Operating Period (January-February 2012) of the Clean Air for London (ClearfLo) campaign. The campaign took place at a rural site in Detling, UK, 45 kilometers southeast of central London. The primary science questions for the ClearfLo winter IOP (intensive operational periods) were: 1) “what is the urban increment of particulate matter (PM) and other pollutants in the greater London area?” and 2) “what is the contribution of solid fuel use for home heating to wintertime PM?” An additionalmore » motivation for the Detling measurements was the question of whether coatings on black carbon particles enhance absorption.« less

  5. 33 CFR 110.52 - Thames River, New London, Conn.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Thames River, New London, Conn. 110.52 Section 110.52 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.52 Thames River, New London, Conn. (a) Area No...

  6. 33 CFR 110.52 - Thames River, New London, Conn.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Thames River, New London, Conn. 110.52 Section 110.52 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.52 Thames River, New London, Conn. (a) Area No...

  7. 33 CFR 110.52 - Thames River, New London, Conn.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Thames River, New London, Conn. 110.52 Section 110.52 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.52 Thames River, New London, Conn. (a) Area No...

  8. 33 CFR 110.52 - Thames River, New London, Conn.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Thames River, New London, Conn. 110.52 Section 110.52 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.52 Thames River, New London, Conn. (a) Area No...

  9. 33 CFR 110.52 - Thames River, New London, Conn.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Thames River, New London, Conn. 110.52 Section 110.52 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.52 Thames River, New London, Conn. (a) Area No...

  10. Why different countries manage death differently: a comparative analysis of modern urban societies.

    PubMed

    Walter, Tony

    2012-03-01

    The sociology of death, dying and bereavement tends to take as its implicit frame either the nation state or a homogenous modernity. Between-nation differences in the management of death and dying are either ignored or untheorized. This article seeks to identify the factors that can explain both similarities and differences in the management of death between different modern western nations. Structural factors which affect all modern nations include urbanization and the division of labour leading to the dominance of professionals, migration, rationality and bureaucracy, information technology and the risk society. How these sociologically familiar structural features are responded to, however, depends on national histories, institutions and cultures. Historically, key transitional periods to modernity, different in different nations, necessitated particular institutional responses in the management of dying and dead bodies. Culturally, key factors include individualism versus collectivism, religion, secularization, boundary regulation, and expressivism. Global flows of death practices depend significantly on subjugated nations' perceptions of colonialism, neo-colonialism and modernity, which can lead to a dominant power's death practices being either imitated or rejected. © London School of Economics and Political Science 2012.

  11. THE LONDON EXTERNAL DEGREE SYSTEM, ORIGINS AND PRESENT PROBLEMS.

    ERIC Educational Resources Information Center

    CHARNLEY, A.H.

    FORMAL RESPONSIBILITY FOR BRITISH ADULTS PURSUING DEGREE COURSES BY HOME STUDY RESTS LARGELY WITH THE UNIVERSITY OF LONDON. ALTHOUGH ABOUT 1,000 STUDENTS ARE BEING TAUGHT AT INSTITUTIONS COOPERATING WITH THE UNIVERSITY OF LONDON, THE MAJOR GROUPS ARE THE HOME STUDENTS (OVER 20,000) AND THE OVERSEAS STUDENTS (OVER 4,000). BRITISH EXTERNAL STUDENTS…

  12. The fourfold Democritus on the stage of early modern science.

    PubMed

    Lüthy, C

    2000-09-01

    The renewed success of ancient atomism in the seventeenth century has baffled historians not only because of the lack of empirical evidence in its favor but also because of the exotic heterogeneity of the models that were proposed under its name. This essay argues that one of the more intriguing reasons for the motley appearance of early modern atomism is that Democritus, with whose name this doctrine was most commonly associated, was a figure of similar incoherence. There existed in fact no fewer than four quite different Democriti of Abdera and as many literary traditions: the atomist, the "laughing philosopher," the moralizing anatomist, and the alchemist. Around the year 1600 the doctrines of these literary figures, three of whom had no tangible connection with atomism, began to merge into further hybrid personae, some of whom possessed notable scientific potential. This essay offers the story of how these Democriti contributed to the rise of incompatible "atomisms."

  13. Fear of Crime among Elderly Jews in Boston and London.

    ERIC Educational Resources Information Center

    Ginsberg, Yona

    1985-01-01

    Examines the impact of fear of crime on the daily behavior of elderly Jews in racially mixed, deteriorating neighborhoods in Boston and London. Results showed the Boston elderly retreated behind locked doors, while the London elderly continued their daily routine. (JAC)

  14. Inner London's Education Authority: Reflections on ILEA Twenty-Five Years after Closure

    ERIC Educational Resources Information Center

    Mitchell, Peter

    2015-01-01

    It is 25 years since the Inner London Education Authority (ILEA) was abolished and management of education in central London transferred to 13 London boroughs. The author reflects on the experience of being an ex-ILEA head teacher, and of managing one of the new local education authorities in the immediate post-ILEA period. He begins by commenting…

  15. London Challenge: Surveys of Pupils and Teachers, 2005. Research Report RR718

    ERIC Educational Resources Information Center

    Ridley, Kate; Knight, Sarah; Scott, Emma; Benton, Tom; Woodthorpe, Adrian

    2006-01-01

    The London Challenge is a Department for Education and Skills (DfES) initiative, which aims to raise levels of attainment in London secondary schools and to create a world class education system in the capital. In 2005, London Challenge commissioned the National Foundation for Educational Research (NFER) to carry out a survey of Year 7 pupils,…

  16. Kashmir--The Key to Peace in Afghanistan

    DTIC Science & Technology

    2013-03-01

    Missile Crisis the U.S. had to learn similar lessons in the early years of it gaining nuclear weapons. Victoria Schofield and Praveen Swami reinforce...12 Praveen Swami, India, Pakistan and the Secret Jihad (London: Routledge, 2007), 204. 13 Peter Lavoy, Asymmetric Warefare in South Asia: the...Swami, Praveen . India, Pakistan and the Secret Jihad. London: Routledge, 2007. Talbot, Ian. Pakistan: A Modern History. New Delhi: Oxford University

  17. Modern turtle origins: the oldest known cryptodire.

    PubMed

    Gaffney, E S; Hutchison, J H; Jenkins, F A; Meeker, L J

    1987-07-17

    The discovery of a turtle in the Early Jurassic(185 million years before present) Kayenta Formation of northeastern Arizona provides significant evidence about the origin of modern turtles. This new taxon possesses many of the primitive features expected in the hypothetical common ancestor of pleurodires and cryptodires, the two groups of modern turtles. It is identified as the oldest known cryptodire because of the presence of a distinctive cryptodiran jaw mechanism consisting of a trochlea over the otic chamber that redirects the line of action of the adductor muscle. Aquatic habits appear to have developed very early in turtle evolution. Kayentachelys extends the known record of cryptodires back at least 45 million years and documents a very early stage in the evolution of modern turtles.

  18. Investigating early modern Ottoman consumer culture in the light of Bursa probate inventories.

    PubMed

    Karababa, Eminegül

    2012-01-01

    This study investigates the development of early modern Ottoman consumer culture. In particular, the democratization of consumption, which is a significant indicator of the development of western consumer cultures, is examined in relation to Ottoman society. Sixteenth- and seventeenth-century probate inventories of the town of Bursa combined with literary and official sources are used in order to identify democratization of consumption and the macro conditions shaping this development. Findings demonstrate that commercialization, international trade, urbanization which created a fluid social structure, and the ability of the state to negotiate with guilds were possible contextual specificities which encouraged the democratization of consumption in the Bursa context.

  19. Comparison of safety equipment between London underground and Beijing subway

    NASA Astrophysics Data System (ADS)

    Chen, T.; Zhang, S. Y.; Zhao, L. Z.; Xia, J. J.; Fu, X. C.; Bao, Z. M.; Chen, Y.; Zhang, X. Z.; Wang, R. J.; Hu, C.; Jing, L. S.; Wang, Y.

    2017-06-01

    The purpose of this paper was to improve the safety equipment’s effectiveness through the comparison. Firstly, the history and safety accident of London Underground and Beijing Subway were shown. Secondly, fire equipment between these two cities was compared including station’s hardware installations and carriage’s hardware installations. Thirdly, the relative software installations were also compared such as emergency drills. The results showed that Beijing Subway’s hardware installations were better than London. However, London Underground’s some installations were more effective than Beijing. Both cities would pay more attention on anti-terrorist in tunnel.

  20. Insecticide ADME for support of early-phase discovery: combining classical and modern techniques.

    PubMed

    David, Michael D

    2017-04-01

    The two factors that determine an insecticide's potency are its binding to a target site (intrinsic activity) and the ability of its active form to reach the target site (bioavailability). Bioavailability is dictated by the compound's stability and transport kinetics, which are determined by both physical and biochemical characteristics. At BASF Global Insecticide Research, we characterize bioavailability in early research with an ADME (Absorption, Distribution, Metabolism and Excretion) approach, combining classical and modern techniques. For biochemical assessment of metabolism, we purify native insect enzymes using classical techniques, and recombinantly express individual insect enzymes that are known to be relevant in insecticide metabolism and resistance. For analytical characterization of an experimental insecticide and its metabolites, we conduct classical radiotracer translocation studies when a radiolabel is available. In discovery, where typically no radiolabel has been synthesized, we utilize modern high-resolution mass spectrometry to probe complex systems for the test compounds and its metabolites. By using these combined approaches, we can rapidly compare the ADME properties of sets of new experimental insecticides and aid in the design of structures with an improved potential to advance in the research pipeline. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  1. Physical Activity in Early and Modern Populations. Papers from the Annual Meeting of the American Academy of Physical Education (59th, Las Vegas, Nevada, April 11-13, 1987). No. 21.

    ERIC Educational Resources Information Center

    Malina, Robert M., Ed.; Eckert, Helen M., Ed.

    Eleven conference papers explore physical activity in ancient societies as well as human adaptation of physical activities in modern society. The following papers are included: (1) "Physical Activity in Early and Modern Populations: An Evolutionary View" (Robert M. Malina); (2) "How Active Were Early Populations? or Squeezing the Fossil Record"…

  2. Woods and Russell, Hill, and the emergence of medical statistics

    PubMed Central

    Farewell, Vern; Johnson, Tony

    2010-01-01

    In 1937, Austin Bradford Hill wrote Principles of Medical Statistics (Lancet: London, 1937) that became renowned throughout the world and is widely associated with the birth of modern medical statistics. Some 6 years earlier Hilda Mary Woods and William Thomas Russell, colleagues of Hill at the London School of Hygiene and Tropical Medicine, wrote a similar book An Introduction to Medical Statistics (PS King and Son: London, 1931) that is little known today. We trace the origins of these two books from the foundations of early demography and vital statistics, and make a detailed examination of some of their chapters. It is clear that these texts mark a watershed in the history of medical statistics that demarcates the vital statistics of the nineteenth and early twentieth centuries from the modern discipline. Moreover, we consider that the book by Woods and Russell is of some importance in the development of medical statistics and we describe and acknowledge their place in the history of this discipline. Copyright © 2010 John Wiley & Sons, Ltd. PMID:20535761

  3. Woods and Russell, Hill, and the emergence of medical statistics.

    PubMed

    Farewell, Vern; Johnson, Tony

    2010-06-30

    In 1937, Austin Bradford Hill wrote Principles of Medical Statistics (Lancet: London, 1937) that became renowned throughout the world and is widely associated with the birth of modern medical statistics. Some 6 years earlier Hilda Mary Woods and William Thomas Russell, colleagues of Hill at the London School of Hygiene and Tropical Medicine, wrote a similar book An Introduction to Medical Statistics (PS King and Son: London, 1931) that is little known today. We trace the origins of these two books from the foundations of early demography and vital statistics, and make a detailed examination of some of their chapters. It is clear that these texts mark a watershed in the history of medical statistics that demarcates the vital statistics of the nineteenth and early twentieth centuries from the modern discipline. Moreover, we consider that the book by Woods and Russell is of some importance in the development of medical statistics and we describe and acknowledge their place in the history of this discipline. (c) 2010 John Wiley & Sons, Ltd.

  4. The epidemiology of suicide on the London Underground.

    PubMed

    O'Donnell, I; Farmer, R D

    1994-02-01

    A database containing details of every incident of suicidal behaviour on the London Underground railway system between 1940 and 1990 was assembled from the records of London Underground Ltd and the British Transport Police. The total number of cases was 3240. The mean annual number of suicidal acts on the London Underground system increased from 36.1 (1940-1949) to 94.1 (1980-1989). There were significantly fewer incidents on Sundays than on the other days of the week and the daily rate was highest in the spring. 64% of incidents involved males and the peak age group for both sexes was 25-34 yr. Suicide verdicts were returned for a greater proportion of women than men. Overall case fatality was 55%. However, case fatality rates differed between stations, environmental factors appearing to influence survival. Possible strategies to prevent railway suicides and reduce the lethality of this method are discussed.

  5. Cosmopolitanism, geographical imaginaries and belonging in North London.

    PubMed

    Devadason, Ranji

    2010-01-01

    Cosmopolitanism has been described as the cultural habitus of globalisation. It is therefore, albeit defined somewhat loosely, often associated with ethnically diverse, global cities. This paper considers the extent to which London engenders cosmopolitan values amongst its residents. It draws on survey data from the LOCAL MULTIDEM study of minorities' political participation to address these themes. The analysis examines perceptions of respect, belonging and geographical imaginaries - amongst established minorities and the ethnic majority - in north London. It is argued that cosmopolitan ethics are transformative and dialectical and, critically, cannot remain the preserve of the privileged in multi-ethnic neighbourhoods. The analysis presented demonstrates that a sense of belonging and cosmopolitan imaginaries are not evenly accessed by different ethnic groups; notably, that Bangladeshi Londoners who are born and bred in the city are less likely to appropriate these discourses than Caribbean, Indian or White residents.

  6. Appendicular robusticity and the paleobiology of modern human emergence.

    PubMed

    Trinkaus, E

    1997-11-25

    The emergence of modern humans in the Late Pleistocene, whatever its phylogenetic history, was characterized by a series of behaviorally important shifts reflected in aspects of human hard tissue biology and the archeological record. To elucidate these shifts further, diaphyseal cross-sectional morphology was analyzed by using cross-sectional areas and second moments of area of the mid-distal humerus and midshaft femur. The humeral diaphysis indicates a gradual reduction in habitual load levels from Eurasian late archaic, to Early Upper Paleolithic early modern, to Middle Upper Paleolithic early modern hominids, with the Levantine Middle Paleolithic early modern humans being a gracile anomalous outlier. The femoral diaphysis, once variation in ecogeographically patterned body proportions is taken into account, indicates no changes across the pre-30,000 years B.P. samples in habitual locomotor load levels, followed by a modest decrease through the Middle Upper Paleolithic.

  7. "This base stallion trade": he-whores and male sexuality on the early modern stage.

    PubMed

    Panek, Jennifer

    2010-01-01

    Recent scholarship on early modern male sexuality has stressed the threat that sexual relations with women were believed to pose to manhood. Focusing on such plays as Middleton's Your Five Gallants (c. 1608), Fletcher and Massinger's The Custom of The Country (c.1620), and Davenant's The Just Italian (1630), this paper analyzes representations of male prostitutes for women to argue that cultural attitudes toward male sexual performance were more complex and self-contradictory than generally acknowledged. The patriarchal codes that warned against effeminating sexual desire and advocated parsimonious seminal “spending” are undermined by their own inherent corollary: the most masculine man is one who can demonstrate unlimited seminal capacity. Furthermore, it has been posited that the early modern period marked the beginning of a shift from “reproductive” to “performative” constructions of manhood, in which the manhood-affirming aspects of male sexuality gradually became unmoored from their traditional association with bloodlines and attached instead to penetrative sexual conquest. The class implications of this shift inform patriarchal anxieties about the superior sexual stamina of servant-class men and their bodily “service” to elite women. Representing a fantasy of empowering male sexuality that relies on detaching virile performance from effeminating desire—a physiologically absurd notion—and on providing sexual “service” while leaving intact both class and gender hierarchies, a successful he-whore like Middleton's Tailby or Davenant's Sciolto playfully challenges the dictates of patriarchal masculinity by fulfilling them in absurd and unorthodox ways. Ultimately, he illuminates just how untenable those dictates might be.

  8. OH 83: A new early modern human fossil cranium from the Ndutu beds of Olduvai Gorge, Tanzania.

    PubMed

    Reiner, Whitney B; Masao, Fidelis; Sholts, Sabrina B; Songita, Agustino Venance; Stanistreet, Ian; Stollhofen, Harald; Taylor, R E; Hlusko, Leslea J

    2017-11-01

    Herein we introduce a newly recovered partial calvaria, OH 83, from the upper Ndutu Beds of Olduvai Gorge, Tanzania. We present the geological context of its discovery and a comparative analysis of its morphology, placing OH 83 within the context of our current understanding of the origins and evolution of Homo sapiens. We comparatively assessed the morphology of OH 83 using quantitative and qualitative data from penecontemporaneous fossils and the W.W. Howells modern human craniometric dataset. OH 83 is geologically dated to ca. 60-32 ka. Its morphology is indicative of an early modern human, falling at the low end of the range of variation for post-orbital cranial breadth, the high end of the range for bifrontal breadth, and near average in frontal length. There have been numerous attempts to use cranial anatomy to define the species Homo sapiens and identify it in the fossil record. These efforts have not met wide agreement by the scientific community due, in part, to the mosaic patterns of cranial variation represented by the fossils. The variable, mosaic pattern of trait expression in the crania of Middle and Late Pleistocene fossils implies that morphological modernity did not occur at once. However, OH 83 demonstrates that by ca. 60-32 ka modern humans in Africa included individuals that are at the fairly small and gracile range of modern human cranial variation. © 2017 Wiley Periodicals, Inc.

  9. Globalization, National Identity, and Citizenship Education: China's Search for Modernization and a Modern Chinese Citizenry

    ERIC Educational Resources Information Center

    Law, Wing-Wah

    2013-01-01

    Since the early 20th century, numerous scholars have proposed theories and models describing, interpreting, and suggesting the development paths countries have taken or should take. None of these, however, can fully explain China's efforts, mainly through education and citizenship education, to modernize itself and foster a modern citizenry since…

  10. Fritz London and the scale of quantum mechanisms

    NASA Astrophysics Data System (ADS)

    Monaldi, Daniela

    2017-11-01

    Fritz London's seminal idea of ;quantum mechanisms of macroscopic scale;, first articulated in 1946, was the unanticipated result of two decades of research, during which London pursued quantum-mechanical explanations of various kinds of systems of particles at different scales. He started at the microphysical scale with the hydrogen molecule, generalized his approach to chemical bonds and intermolecular forces, then turned to macrophysical systems like superconductors and superfluid helium. Along this path, he formulated a set of concepts-the quantum mechanism of exchange, the rigidity of the wave function, the role of quantum statistics in multi-particle systems, the possibility of order in momentum space-that eventually coalesced into a new conception of systems of equal particles. In particular, it was London's clarification of Bose-Einstein condensation that enabled him to formulate the notion of superfluids, and led him to the recognition that quantum mechanics was not, as it was commonly assumed, relevant exclusively as a micromechanics.

  11. Authoritative Images. The Kiwi and the Transactions of the Zoological Society of London.

    PubMed

    Canadelli, Elena

    2015-01-01

    The first exemplar of a kiwi, the wingless bird of New Zealand, arrived in the form of a lifeless specimen in Europe in 1812. A debate was sparked over the appearance and nature of this strange creature and indeed whether it actually existed. In 1833 the Transactions of the Zoological Society of London entered the debate and the illustrations published in this journal contributed greatly to the acceptance and further study of the kiwi. Some of the most eminent British zoologists and anatomists of the time were involved, from William Yarrell to Richard Owen, and from John Gould to Abraham Dee Bartlett. This crucial period in the discussion, which would extend over two decades and would only be brought to a close with the arrival of the first living specimen in the London Zoological Garden in 1851, will be analyzed based on a detailed examination of the reports published in the Transactions and other journals. This essay will show how images of the bird were produced and used by zoologists during different stages in the early research on the bird and how these figures circulated inside and outside the zoologists' community.

  12. Socio-cultural factors in dental diseases in the Medieval and early Modern Age of northern Spain.

    PubMed

    Lopez, Belen; Pardiñas, Antonio F; Garcia-Vazquez, Eva; Dopico, Eduardo

    2012-02-01

    The aim of this study is to present, discuss and compare the results of pathological conditions in teeth from skeletal remains found in the northern part of the Iberian Peninsula (Spain) in four Medieval cemeteries (late 15th century) and three cemeteries from the Modern Age (late 18th century). The final objective was to evaluate the impact of socioeconomic and cultural changes that took place during the early Modern Age in Spain, on oral health. Dental caries and antemortem tooth loss were considered as indicators of dental disease. A significant increase of both dental caries and antemortem tooth loss occurred in Modern Age individuals when compared to Medieval values, as reported for other regions. Increased trade with other continents may explain this deterioration of dental health, as food exchanges (mainly with America) contributed to diet changes for the overall population, including higher carbohydrate consumption (introduction of potatoes) at the expense of other vegetables. A sex-specific increase of dental disease with age, and a significantly higher prevalence of carious lesions in Modern Age females than in males, were also found. These changes can be explained by women having had limited access to dental care after the Middle-Modern Age transition, as a consequence of socio-cultural and political changes. In these changes, an increasing influence of the Catholic Church in Spanish society has to be noted, as it can contribute to the explanation of the unequal dental health of men and women. Women were socially excluded from dental care by regulations inspired by religious precepts. Copyright © 2011 Elsevier GmbH. All rights reserved.

  13. Practicing Reflexivity in the Study of Italian Migrants in London

    ERIC Educational Resources Information Center

    Seganti, Francesca Romana

    2010-01-01

    This article discusses the centrality of reflexivity in qualitative research through examples from my study on the role new media play in the lives of Italians in London. My hypothesis was that Italians were "in transit" in London and they were using new media to build "temporary" communities. I conducted in-depth interviews…

  14. Royal london hospital set P28 plans 30th anniversary reunion.

    PubMed

    Sibthorpe, Fran

    2013-04-03

    Members of Set P28 at the Royal London Hospital who began their training in February 1980 are planning a reunion on July 27 in London. The venue will be announced later. Email fran-joy@hotmail.com for details.

  15. Building a Hypertextual Digital Library in the Humanities: A Case Study on London.

    ERIC Educational Resources Information Center

    Crane, Gregory; Smith, David A.; Wulfman, Clifford E.

    This paper describes the creation of a new humanities digital library collection: 11,000,000 words and 10,000 images representing books, images, and maps on pre-twentieth century London and its environs. The London collection contained far more dense and precise information than the materials from the Greco-Roman world. The London collection thus…

  16. Dental enamel defects in German medieval and early-modern-age populations.

    PubMed

    Lang, J; Birkenbeil, S; Bock, S; Heinrich-Weltzien, R; Kromeyer-Hauschild, K

    2016-11-01

    Aim of this study was to investigate the frequency and type of developmental defects of enamel (DDE) in a medieval and an early-modern-age population from Thuringia, Germany. Sixty-six skeletons subdivided into 31 single burials (12 th /13 th c.) and 35 individuals buried in groups (15 th /16 th c.) were examined. DDE were classified on 1,246 teeth according to the DDE index. Molar-incisor-hypomineralisation (MIH), a special type of DDE, was recorded according to the European Academy of Paediatric Dentistry (EAPD) criteria. DDE was found in 89.4% of the individuals (single burials 90.3% and group burials 88.6%). Hypoplastic pits were the most frequent defect in primary teeth and linear enamel hypoplasia (LEH) in permanent teeth. 13 individuals (24.1%) showed at least one hypomineralised permanent tooth, 12.2% had MIH on at least one first permanent molar and 10.0% in permanent incisors. Second primary molars were affected in 8.0% of the children and juveniles. No individual suffered from affected molars and incisors in combination. Endogenous factors like nutritional deficiencies and health problems in early childhood could have been aetiological reasons of DDE and MIH. The frequency of DDE and MIH might have been masked by extended carious lesions, dental wear and ante-mortem tooth loss.

  17. Early postdisaster health outreach to modern families: a cross-sectional study.

    PubMed

    Haga, Jon Magnus; Stene, Lise Eilin; Wentzel-Larsen, Tore; Thoresen, Siri; Dyb, Grete

    2015-12-17

    This study investigated whether the early outreach programme following the Utøya massacre reached out to the parents of the young survivors. Additionally, we explored whether specialised mental healthcare services were provided to parents presenting elevated levels of PTSD and depression reactions. Cross-sectional survey, face-to-face interviews and questionnaires. Norway, aftermath of the Utøya massacre, 4-7 months postdisaster. Following the Utøya massacre, proactive early outreach programmes were launched in all municipalities that were affected, facilitating access to appropriate healthcare services. A total of 453 parents of the Utøya survivors aged 13-33 years took part. Overall, 59.8% of the survivors were represented by one or more parent in our study. Engagement with the proactive early outreach programme (psychosocial crisis teams and contact persons in the municipalities), utilisation of healthcare services (general practitioner and specialised mental healthcare services) and mental distress (UCLA PTSD-RI and HSCL-8). A majority of the participants reported contact with the proactive early outreach programme (crisis team, 73.9%; and contact person, 73.0%). Failure of outreach to parents was significantly associated with non-intact family structure (crisis team: OR 1.69, 95% CI 1.05 to 2.72, p=0.032) and non-Norwegian origin (crisis team: OR 2.39, 95% CI 1.14 to 4.98, p=0.021). Gender of the parent was not significantly associated with failure of the outreach programme (p ≥ 0.075). Provision of specialised mental healthcare services was significantly associated with higher levels of PTSD (OR 2.08, 95% CI 1.55 to 2.79, p<0.001) and depression (OR 2.42, 95% CI 1.71 to 3.43, p<0.001) and not with the sociodemography (p ≥ 0.122). Proactive early outreach strategies may be helpful in identifying healthcare needs and facilitating access to the required services in a population struck by disaster. Our findings prompt increased attention to the complexity

  18. Genealogical relationships between early medieval and modern inhabitants of Piedmont.

    PubMed

    Vai, Stefania; Ghirotto, Silvia; Pilli, Elena; Tassi, Francesca; Lari, Martina; Rizzi, Ermanno; Matas-Lalueza, Laura; Ramirez, Oscar; Lalueza-Fox, Carles; Achilli, Alessandro; Olivieri, Anna; Torroni, Antonio; Lancioni, Hovirag; Giostra, Caterina; Bedini, Elena; Pejrani Baricco, Luisella; Matullo, Giuseppe; Di Gaetano, Cornelia; Piazza, Alberto; Veeramah, Krishna; Geary, Patrick; Caramelli, David; Barbujani, Guido

    2015-01-01

    In the period between 400 to 800 AD, also known as the period of the Barbarian invasions, intense migration is documented in the historical record of Europe. However, little is known about the demographic impact of these historical movements, potentially ranging from negligible to substantial. As a pilot study in a broader project on Medieval Europe, we sampled 102 specimens from 5 burial sites in Northwestern Italy, archaeologically classified as belonging to Lombards or Longobards, a Germanic people ruling over a vast section of the Italian peninsula from 568 to 774. We successfully amplified and typed the mitochondrial hypervariable region I (HVR-I) of 28 individuals. Comparisons of genetic diversity with other ancient populations and haplotype networks did not suggest that these samples are heterogeneous, and hence allowed us to jointly compare them with three isolated contemporary populations, and with a modern sample of a large city, representing a control for the effects of recent immigration. We then generated by serial coalescent simulations 16 millions of genealogies, contrasting a model of genealogical continuity with one in which the contemporary samples are genealogically independent from the medieval sample. Analyses by Approximate Bayesian Computation showed that the latter model fits the data in most cases, with one exception, Trino Vercellese, in which the evidence was compatible with persistence up to the present time of genetic features observed among this early medieval population. We conclude that it is possible, in general, to detect evidence of genealogical ties between medieval and specific modern populations. However, only seldom did mitochondrial DNA data allow us to reject with confidence either model tested, which indicates that broader analyses, based on larger assemblages of samples and genetic markers, are needed to understand in detail the effects of medieval migration.

  19. Genealogical Relationships between Early Medieval and Modern Inhabitants of Piedmont

    PubMed Central

    Vai, Stefania; Ghirotto, Silvia; Pilli, Elena; Tassi, Francesca; Lari, Martina; Rizzi, Ermanno; Matas-Lalueza, Laura; Ramirez, Oscar; Lalueza-Fox, Carles; Achilli, Alessandro; Olivieri, Anna; Torroni, Antonio; Lancioni, Hovirag; Giostra, Caterina; Bedini, Elena; Baricco, Luisella Pejrani; Matullo, Giuseppe; Di Gaetano, Cornelia; Piazza, Alberto; Veeramah, Krishna; Geary, Patrick; Caramelli, David; Barbujani, Guido

    2015-01-01

    In the period between 400 to 800 AD, also known as the period of the Barbarian invasions, intense migration is documented in the historical record of Europe. However, little is known about the demographic impact of these historical movements, potentially ranging from negligible to substantial. As a pilot study in a broader project on Medieval Europe, we sampled 102 specimens from 5 burial sites in Northwestern Italy, archaeologically classified as belonging to Lombards or Longobards, a Germanic people ruling over a vast section of the Italian peninsula from 568 to 774. We successfully amplified and typed the mitochondrial hypervariable region I (HVR-I) of 28 individuals. Comparisons of genetic diversity with other ancient populations and haplotype networks did not suggest that these samples are heterogeneous, and hence allowed us to jointly compare them with three isolated contemporary populations, and with a modern sample of a large city, representing a control for the effects of recent immigration. We then generated by serial coalescent simulations 16 millions of genealogies, contrasting a model of genealogical continuity with one in which the contemporary samples are genealogically independent from the medieval sample. Analyses by Approximate Bayesian Computation showed that the latter model fits the data in most cases, with one exception, Trino Vercellese, in which the evidence was compatible with persistence up to the present time of genetic features observed among this early medieval population. We conclude that it is possible, in general, to detect evidence of genealogical ties between medieval and specific modern populations. However, only seldom did mitochondrial DNA data allow us to reject with confidence either model tested, which indicates that broader analyses, based on larger assemblages of samples and genetic markers, are needed to understand in detail the effects of medieval migration. PMID:25635682

  20. Casebooks in early modern England: medicine, astrology, and written records.

    PubMed

    Kassell, Lauren

    2014-01-01

    Casebooks are the richest sources that we have for encounters between early modern medical practitioners and their patients. This article compares astrological and medical records across two centuries, focused on England, and charts developments in the ways in which practitioners kept records and reflected on their practices. Astrologers had a long history of working from particular moments, stellar configurations, and events to general rules. These practices required systematic notation. Physicians increasingly modeled themselves on Hippocrates, recording details of cases as the basis for reasoned expositions of the histories of disease. Medical records, as other scholars have demonstrated, shaped the production of medical knowledge. Instead, this article focuses on the nature of casebooks as artifacts of the medical encounter. It establishes that casebooks were serial records of practice, akin to diaries, testimonials, and registers; identifies extant English casebooks and the practices that led to their production and preservation; and concludes that the processes of writing, ordering, and preserving medical records are as important for understanding the medical encounter as the records themselves.

  1. Alternative Spaces of Learning in East London: Opportunities and Challenges

    ERIC Educational Resources Information Center

    Sneddon, Raymonde; Martin, Peter

    2012-01-01

    This article emerges from an ongoing exploration into how British minority ethnic communities in the London area create spaces in community-based programs to maintain or develop their languages and literacies. In London, more than one-third of the 850,000 school children speak a language other than English at home (Baker & Eversley, 2000).…

  2. Psychological and behavioural reactions to the bombings in London on 7 July 2005: cross sectional survey of a representative sample of Londoners

    PubMed Central

    Rubin, G James; Brewin, Chris R; Greenberg, Neil; Simpson, John; Wessely, Simon

    2005-01-01

    Objectives To assess the impact of the bombings in London on 7 July on stress levels and travel intentions in London's population. Design A cross sectional telephone survey using random digit dialling was conducted to contact a representative sample of adults. Respondents were asked to participate in an interview enquiring about current levels of stress and travel intentions. Setting Interviews took place between 18 and 20 July. Participants 1010 participants (10% of the eligible people we contacted) completed the interviews. Main outcome measures Main outcomes were presence of substantial stress, measured by using an identical tool to that used to assess the emotional impact of 11 September 2001 in the US population, and intention to travel less on tubes, trains, and buses, or into central London, once the transport network had returned to normal. Results 31% of Londoners reported substantial stress and 32% reported an intention to travel less. Among other things, having difficulty contacting friends or family by mobile phone (odds ratio 1.7, 95% confidence interval 1.1 to 2.7), having thought you could have been injured or killed (3.8, 2.4 to 6.2), and being Muslim (4.0, 2.5 to 6.6) were associated with a greater presence of substantial stress, whereas being white (0.3, 0.2 to 0.4) and having previous experience of terrorism (0.6, 0.5 to 0.9) were associated with reduced stress. Only 12 participants (1%) felt that they needed professional help to deal with their emotional response to the attacks. Conclusions Although the psychological needs of those intimately caught up in the attacks will require further assessment, we found no evidence of a widespread desire for professional counselling. The attacks have inflicted disproportionately high levels of distress among non-white and Muslim Londoners. PMID:16126821

  3. Multifractal to monofractal evolution of the London street network.

    PubMed

    Murcio, Roberto; Masucci, A Paolo; Arcaute, Elsa; Batty, Michael

    2015-12-01

    We perform a multifractal analysis of the evolution of London's street network from 1786 to 2010. First, we show that a single fractal dimension, commonly associated with the morphological description of cities, does not suffice to capture the dynamics of the system. Instead, for a proper characterization of such a dynamics, the multifractal spectrum needs to be considered. Our analysis reveals that London evolves from an inhomogeneous fractal structure, which can be described in terms of a multifractal, to a homogeneous one, which converges to monofractality. We argue that London's multifractal to monofractal evolution might be a special outcome of the constraint imposed on its growth by a green belt. Through a series of simulations, we show that multifractal objects, constructed through diffusion limited aggregation, evolve toward monofractality if their growth is constrained by a nonpermeable boundary.

  4. Case studies of transport for London.

    DOT National Transportation Integrated Search

    2009-01-01

    This project was motivated by the election of Ken Livingston as Mayor of London in : 2000. Mayor Livingston campaigned on a platform of improving transportation service through : such innovative means as congestion pricing. Mayor Livingston relied on...

  5. Light Water Reactor Sustainability Program Operator Performance Metrics for Control Room Modernization: A Practical Guide for Early Design Evaluation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ronald Boring; Roger Lew; Thomas Ulrich

    2014-03-01

    As control rooms are modernized with new digital systems at nuclear power plants, it is necessary to evaluate the operator performance using these systems as part of a verification and validation process. There are no standard, predefined metrics available for assessing what is satisfactory operator interaction with new systems, especially during the early design stages of a new system. This report identifies the process and metrics for evaluating human system interfaces as part of control room modernization. The report includes background information on design and evaluation, a thorough discussion of human performance measures, and a practical example of how themore » process and metrics have been used as part of a turbine control system upgrade during the formative stages of design. The process and metrics are geared toward generalizability to other applications and serve as a template for utilities undertaking their own control room modernization activities.« less

  6. ‘Very Sore Nights and Days’: The Child’s Experience of Illness in Early Modern England, c.1580–1720

    PubMed Central

    NEWTON, HANNAH

    2011-01-01

    Sick children were ubiquitous in early modern England, and yet they have received very little attention from historians. Taking the elusive perspective of the child, this article explores the physical, emotional, and spiritual experience of illness in England between approximately 1580 and 1720. What was it like being ill and suffering pain? How did the young respond emotionally to the anticipation of death? It is argued that children’s experiences were characterised by profound ambivalence: illness could be terrifying and distressing, but also a source of emotional and spiritual fulfilment and joy. This interpretation challenges the common assumption amongst medical historians that the experiences of early modern patients were utterly miserable. It also sheds light on children’s emotional feelings for their parents, a subject often overlooked in the historiography of childhood. The primary sources used in this article include diaries, autobiographies, letters, the biographies of pious children, printed possession cases, doctors’ casebooks, and theological treatises concerning the afterlife. PMID:21461308

  7. Patterns of long bone growth in a mid-19th century documented sample of the urban poor from Bethnal Green, London, UK.

    PubMed

    Ives, Rachel; Humphrey, Louise

    2017-05-01

    Studies of male and female long bone growth in past populations are limited and usually constrained by the lack of personal identification. This article aimed to evaluate long bone growth in a series of mid-19 th century documented burials associated with the urban poor from Bethnal Green, London, UK. Maximum diaphyseal lengths from 74 males and 70 females (2 months to 12 years) were compared to modern reference data from North America. Diaphyseal lengths were expressed as a percentage of expected length and an average percentage value was calculated across all available long bones. An index of growth progression was introduced to explore differences in the progress of males and females towards their projected adult size. Deviation from the expected growth attainment was evident in both sexes in the archaeological series by 2-4 months of age. Only 19.4% (28/144) of the children had attained an average long bone length >90% of the predicted mean in the reference series. The percentage of expected growth attainment decreased steadily in both sexes during infancy and early childhood. Overall, females deviated further from their expected growth progression than males. Growth faltering in both males and females was established during infancy (<1 year) with no evidence for recovery in older age groups. Early weaning and inadequate artificial feeding, together with impoverished living conditions and limited sanitary provision, most likely impacted on childhood growth. © 2017 Wiley Periodicals, Inc.

  8. Ambulance services in London and Great Britain from 1860 until today: a glimpse of history gleaned mainly from the pages of contemporary journals.

    PubMed

    Pollock, Alexander

    2013-03-01

    Little has been published on the subject of civil ambulance services and their development from the mid-19th century in the UK until modern times. There is limited secondary literature available which provides useful background information on the subject and most organisations may give brief histories of their early days but these sources lack historical adequacy in terms of detail. This article shows part of the uncertain path which the history followed towards the service which we enjoy today. From the pages of the British Medical Journal and the Lancet and Hansard, the battle to set up the service is followed and an indication of the drivers towards change over the period is revealed in the attitudes expressed. In particular, the two World Wars are seen to be the stepwise stimuli to providing a necessary service to the British population where the will to achieve this had hitherto been lacking at a parliamentary level. The history of the London Ambulance Service is chosen because more is written about it in these journals but services in other British cities and the USA are mentioned since they played a part in influencing change.

  9. 'A WONDERFULL MONSTER BORNE IN GERMANY': HAIRY GIRLS IN MEDIEVAL AND EARLY MODERN GERMAN BOOK, COURT AND PERFORMANCE CULTURE.

    PubMed

    Katritzky, M A

    2014-09-24

    Human hirsuteness, or pathological hair growth, can be symptomatic of various conditions, including genetic mutation or inheritance, and some cancers and hormonal disturbances. Modern investigations into hirsuteness were initiated by nineteenth-century German physicians. Most early modern European cases of hypertrichosis (genetically determined all-over body and facial hair) involve German-speaking parentage or patronage, and are documented in German print culture. Through the Wild Man tradition, modern historians routinely link early modern reception of historical hypertrichosis cases to issues of ethnicity without, however, recognising early modern awareness of links between temporary hirsuteness and the pathological nexus of starvation and anorexia. Here, four cases of hirsute females are reconsidered with reference to this medical perspective, and to texts and images uncovered by my current research at the Herzog August Library and German archives. One concerns an Italian girl taken to Prague in 1355 by the Holy Roman Empress, Anna von Schweidnitz. Another focuses on Madeleine and Antonietta Gonzalez, daughters of the 'Wild Man' of Tenerife, documented at German courts in the 1580s. The third and fourth cases consider the medieval bearded Sankt Kümmernis (also known as St Wilgefortis or St Uncumber), and the seventeenth-century Bavarian fairground performer Barbara Urslerin. Krankhafter menschlicher Hirsutismus kann aufgrund unterschiedlicher Ursachen auftreten, zu denen u.a. genetische Veländerungen und Vererbung, verschiedene Krebserkrankungen und hormonelle Störungen gehören. Die moderne Hirsutismus-Forschung ist im 19. Jh. von deutschen Forschern initiiert worden. Die meisten europäischen frühneuzeitlichen Erscheinungen von Hypertrichose (dem genetisch bedingten Haarwuchs am gesamten Körper und im Gesicht) gehen auf deutschsprachige Eltern oder Förderer zurück und sind in Deutschland in den Druck gelangt. Bei Untersuchungen des Motivs des Wilden

  10. Training the intelligent eye: understanding illustrations in early modern astronomy texts.

    PubMed

    Crowther, Kathleen M; Barker, Peter

    2013-09-01

    Throughout the early modern period, the most widely read astronomical textbooks were Johannes de Sacrobosco's De sphaera and the Theorica planetarum, ultimately in the new form introduced by Georg Peurbach. This essay argues that the images in these texts were intended to develop an "intelligent eye." Students were trained to transform representations of specific heavenly phenomena into moving mental images of the structure of the cosmos. Only by learning the techniques of mental visualization and manipulation could the student "see" in the mind's eye the structure and motions of the cosmos. While anyone could look up at the heavens, only those who had acquired the intelligent eye could comprehend the divinely created order of the universe. Further, the essay demonstrates that the visual program of the Sphaera and Theorica texts played a significant and hitherto unrecognized role in later scientific work. Copernicus, Galileo, and Kepler all utilized the same types of images in their own texts to explicate their ideas about the cosmos.

  11. Philosophy of experiment in early modern England: the case of Bacon, Boyle and Hooke.

    PubMed

    Anstey, Peter R

    2014-01-01

    Serious philosophical reflection on the nature of experiment began in earnest in the seventeenth century. This paper expounds the most influential philosophy of experiment in seventeenth-century England, the Bacon-Boyle-Hooke view of experiment. It is argued that this can only be understood in the context of the new experimental philosophy practised according to the Baconian theory of natural history. The distinctive typology of experiments of this view is discussed, as well as its account of the relation between experiment and theory. This leads into an assessment of other recent discussions of early modern experiment, namely, those of David Gooding, Thomas Kuhn, J.E. Tiles and Peter Dear.

  12. The social impact of dizziness in London and Siena.

    PubMed

    Bronstein, Adolfo M; Golding, John F; Gresty, Michael A; Mandalà, Marco; Nuti, Daniele; Shetye, Anu; Silove, Yvonne

    2010-02-01

    Although dizziness is a common presenting symptom in general and hospital practice, its social cost is not known. We assessed the social and work life impact of dizziness on patients in two contrasting European cities, Siena and London. First, we developed the 'Social life & Work Impact of Dizziness questionnaire' (SWID), which was validated by administering it to 43 patients with dizziness and 45 normal controls and by correlating the results with the EQ-5D (Europe quality of life) questionnaire. The SWID and EQ-5D scores were worse in patients than controls (p < 0.001) and the two correlated significantly (r = 0.50 p < 0.001). Then two hundred consecutive patients per city attending tertiary specialised 'dizzy patient' clinics, one in London led by a neurologist, one in Siena led by an ear, nose and throat specialist (ENT), were investigated with SWID. Amongst the 400 patients, 27% reported changing their jobs and 21% giving up work as a result of the dizziness. Over 50% of patients felt that their efficiency at work had dropped considerably. The mean number of days off work attributed to the dizziness in the previous 6 months was 7.15 days. Social life was disrupted in 57% of all 400 patients. Factor analysis identified that detrimental effects on work, travel, social and family life combine to create a single factor accounting for much of the overall impact of their dizziness. Significant differences in some measures of handicap between London and Siena emerged, with London patients often faring worse. Reasons for these location differences include, as expected, a higher proportion of neurological patients in London than in Siena. However, factors related to city demographics and social cohesion may also modulate the impact on quality of life and working practice. Regardless of inter-city differences, these findings highlight the high social and economic impact of dizziness.

  13. Soul sisters: the St. John and Raynard nurses in nineteenth century London.

    PubMed

    Williamson, L

    1996-01-01

    This paper uses the archives of the St John's training institution for nurses and the Raynard Mission to determine the extent to which cultural images and specialised space defined and drove the nursing profession in nineteenth and early twentieth century London. Emphasis is placed upon image and rhetoric, both sacred and secular, and the way the two combined to define the 'ideal' Victorian woman and nursing in the nineteenth and early twentieth centuries, and the understanding and treatment of illness. Research to date suggests that through a process of rationalisation of biblical and socio-cultural rhetoric, a specialisation of space, symbolic and literal, abstract and real was created; this enabled women to work in a gendered enclave, the organisational structure and rhetoric of which paralleled that of nunneries or convents. And even as the 'secular' became dominant in medical attitudes and treatment, the 'sacred'aspect of nursing and the emphasis placed upon it as being a vocation remained strong.

  14. The evolution of modern human brain shape

    PubMed Central

    Neubauer, Simon; Hublin, Jean-Jacques; Gunz, Philipp

    2018-01-01

    Modern humans have large and globular brains that distinguish them from their extinct Homo relatives. The characteristic globularity develops during a prenatal and early postnatal period of rapid brain growth critical for neural wiring and cognitive development. However, it remains unknown when and how brain globularity evolved and how it relates to evolutionary brain size increase. On the basis of computed tomographic scans and geometric morphometric analyses, we analyzed endocranial casts of Homo sapiens fossils (N = 20) from different time periods. Our data show that, 300,000 years ago, brain size in early H. sapiens already fell within the range of present-day humans. Brain shape, however, evolved gradually within the H. sapiens lineage, reaching present-day human variation between about 100,000 and 35,000 years ago. This process started only after other key features of craniofacial morphology appeared modern and paralleled the emergence of behavioral modernity as seen from the archeological record. Our findings are consistent with important genetic changes affecting early brain development within the H. sapiens lineage since the origin of the species and before the transition to the Later Stone Age and the Upper Paleolithic that mark full behavioral modernity. PMID:29376123

  15. The evolution of modern human brain shape.

    PubMed

    Neubauer, Simon; Hublin, Jean-Jacques; Gunz, Philipp

    2018-01-01

    Modern humans have large and globular brains that distinguish them from their extinct Homo relatives. The characteristic globularity develops during a prenatal and early postnatal period of rapid brain growth critical for neural wiring and cognitive development. However, it remains unknown when and how brain globularity evolved and how it relates to evolutionary brain size increase. On the basis of computed tomographic scans and geometric morphometric analyses, we analyzed endocranial casts of Homo sapiens fossils ( N = 20) from different time periods. Our data show that, 300,000 years ago, brain size in early H. sapiens already fell within the range of present-day humans. Brain shape, however, evolved gradually within the H. sapiens lineage, reaching present-day human variation between about 100,000 and 35,000 years ago. This process started only after other key features of craniofacial morphology appeared modern and paralleled the emergence of behavioral modernity as seen from the archeological record. Our findings are consistent with important genetic changes affecting early brain development within the H. sapiens lineage since the origin of the species and before the transition to the Later Stone Age and the Upper Paleolithic that mark full behavioral modernity.

  16. Imaging sport at the Grosvenor School of Modern Art (1929-37).

    PubMed

    O'Mahony, Mike

    2011-01-01

    The mass popularity of sport in Britain during the inter-war years was a source of fascination and inspiration for a group of artists working at the Grosvenor School of Modern Art in London. Although largely neglected by their contemporaries, sport was embraced by Grosvenor School artists as a means to engage with both modernity and tradition within contemporary British culture. This essay examines one work, Cyril Power's 1930 linocut print, 'The Eight', as a case study to investigate the interrelationship between two cultural activities frequently regarded as at opposing ends of the cultural spectrum: art and sport. By simultaneously drawing upon a rich heritage of visual culture conventions and deploying new media and methods to represent the excitement, dynamism and sheer energy of sport, Power's work offers an insight into how visual culture can engage with, and enhance, our understanding of contemporary debates and practices in both fields of activity.

  17. Accelerated Innovation Deployment (AID) Demonstration : KYTC—Roundabout Installation Project in London, Kentucky.

    DOT National Transportation Integrated Search

    2017-11-01

    This document serves as the final report on the construction and opening of the Roundabout Project in London, Kentucky (Kentucky Item Number 11904.1). This project (hereafter referred to as the London Roundabout) was constructed on the authority o...

  18. The Modern Religious Language of Education: Rousseau's "Emile"

    ERIC Educational Resources Information Center

    Osterwalder, Fritz

    2012-01-01

    The Republican education, its concepts, theories, and form of discourse belong to the shared European heritage of the pre-modern Age. The pedagogy of humanism and its effects on the early Modern Age are represented by Republicanism. Even if Republicanism found a political continuation in liberalism and democratism of the Modern Age, the same…

  19. HIV in East London: ethnicity, gender and risk. Design and methods.

    PubMed

    Elford, Jonathan; Anderson, Jane; Bukutu, Cecilia; Ibrahim, Fowzia

    2006-06-09

    While men who have sex with men remain the group at greatest risk of acquiring HIV infection in the UK, the number of new diagnoses among heterosexuals has risen steadily over the last five years. In the UK, three-quarters of heterosexual men and women diagnosed with HIV in 2004 probably acquired their infection in Africa. This changing epidemiological pattern is particularly pronounced in East London because of its ethnically diverse population. The objective of the study was to examine the social, economic and behavioural characteristics of patients with HIV infection currently receiving treatment and care in hospitals in East London. The research focused on ethnicity, gender, sexuality, education, employment, housing, HIV treatment, stigma, discrimination, religion, migration and sexual risk behaviour. People diagnosed with HIV infection attending outpatient treatment clinics at St Bartholomew's, the Royal London, Whipp's Cross, Homerton, Newham and Barking hospitals (all in East London) over a 4-6 month period were invited to participate in the study in 2004-2005. Those who agreed to participate completed a confidential, self-administered pen-and-paper questionnaire. During the study period, 2680 patients with HIV attended the outpatient clinics in the six participating hospitals, of whom 2299 were eligible for the study and 1687 completed a questionnaire. The response rate was 73% of eligible patients and 63% of all patients attending the clinics during the survey period. A clinic-based study has allowed us to survey nearly 1700 patients with HIV from diverse backgrounds receiving treatment and care in East London. The data collected in this study will provide valuable information for the planning and delivery of appropriate clinical care, social support and health promotion for people living with HIV not only in East London but in other parts of the capital as well as elsewhere in the UK.

  20. The Live Chicken Treatment for Buboes: Trying a Plague Cure in Medieval and Early Modern Europe.

    PubMed

    Heinrichs, Erik A

    2017-01-01

    This article traces a seven-hundred-year history of one puzzling treatment for plague buboes that used the rumps of chickens to draw out the bubo's poisons. It traces the origin of the recipe to Avicenna's Canon and explores how medieval and early modern physicians altered the treatment and explained its workings up to the early eighteenth century. Much of the analysis focuses on the variants of the recipe that German physicians created as they adapted or elaborated on older recipes. This article argues that most variations of the treatment likely resulted from physicians trying ideas on paper, rather than in practice, as they attempted to unlock the mysteries of the plague's underlying poisons. Starting in the sixteenth century, however, evidence suggests that practice began to play an important role in the adaptation and interpretation of the "live chicken" recipes.

  1. (See symbol in text) in early modern discussions of the passions: Stoicism, Christianity and natural history.

    PubMed

    Kraye, Jill

    2012-01-01

    This paper examines the reception of the Stoic theory of the passions in the early modern period, highlighting various differences between the way notions such as (see symbol in text) (complete freedom from passions) and(see symbol in text) (pre-passions) were handled and interpreted by Continental and English authors. Both groups were concerned about the compatibility of Stoicism with Christianity, but came to opposing conclusions; and while the Continental scholars drew primarily on ancient philosophical texts, the English ones relied, in addition, on experience and observation, developing a natural history of the passions.

  2. ‘A Wonderfull Monster Borne in Germany’: Hairy Girls in Medieval and Early Modern German Book, Court and Performance Culture*

    PubMed Central

    Katritzky, MA

    2014-01-01

    Human hirsuteness, or pathological hair growth, can be symptomatic of various conditions, including genetic mutation or inheritance, and some cancers and hormonal disturbances. Modern investigations into hirsuteness were initiated by nineteenth-century German physicians. Most early modern European cases of hypertrichosis (genetically determined all-over body and facial hair) involve German-speaking parentage or patronage, and are documented in German print culture. Through the Wild Man tradition, modern historians routinely link early modern reception of historical hypertrichosis cases to issues of ethnicity without, however, recognising early modern awareness of links between temporary hirsuteness and the pathological nexus of starvation and anorexia. Here, four cases of hirsute females are reconsidered with reference to this medical perspective, and to texts and images uncovered by my current research at the Herzog August Library and German archives. One concerns an Italian girl taken to Prague in 1355 by the Holy Roman Empress, Anna von Schweidnitz. Another focuses on Madeleine and Antonietta Gonzalez, daughters of the ‘Wild Man’ of Tenerife, documented at German courts in the 1580s. The third and fourth cases consider the medieval bearded Sankt Kümmernis (also known as St Wilgefortis or St Uncumber), and the seventeenth-century Bavarian fairground performer Barbara Urslerin. Krankhafter menschlicher Hirsutismus kann aufgrund unterschiedlicher Ursachen auftreten, zu denen u.a. genetische Veränderungen und Vererbung, verschiedene Krebserkrankungen und hormonelle Störungen gehören. Die moderne Hirsutismus-Forschung ist im 19. Jh. von deutschen Forschern initiiert worden. Die meisten europäischen frühneuzeitlichen Erscheinungen von Hypertrichose (dem genetisch bedingten Haarwuchs am gesamten Körper und im Gesicht) gehen auf deutschsprachige Eltern oder Förderer zurück und sind in Deutschland in den Druck gelangt. Bei Untersuchungen des Motivs des

  3. Evaluating methane inventories by isotopic analysis in the London region.

    PubMed

    Zazzeri, G; Lowry, D; Fisher, R E; France, J L; Lanoisellé, M; Grimmond, C S B; Nisbet, E G

    2017-07-07

    A thorough understanding of methane sources is necessary to accomplish methane reduction targets. Urban environments, where a large variety of methane sources coexist, are one of the most complex areas to investigate. Methane sources are characterised by specific δ 13 C-CH 4 signatures, so high precision stable isotope analysis of atmospheric methane can be used to give a better understanding of urban sources and their partition in a source mix. Diurnal measurements of methane and carbon dioxide mole fraction, and isotopic values at King's College London, enabled assessment of the isotopic signal of the source mix in central London. Surveys with a mobile measurement system in the London region were also carried out for detection of methane plumes at near ground level, in order to evaluate the spatial allocation of sources suggested by the inventories. The measured isotopic signal in central London (-45.7 ±0.5‰) was more than 2‰ higher than the isotopic value calculated using emission inventories and updated δ 13 C-CH 4 signatures. Besides, during the mobile surveys, many gas leaks were identified that are not included in the inventories. This suggests that a revision of the source distribution given by the emission inventories is needed.

  4. City lights of London, England taken during Expedition Six

    NASA Image and Video Library

    2003-02-04

    ISS006-E-22939 (4 February 2003) --- City lights of London, England were captured with a digital still camera by one of the Expedition Six crewmembers on the International Space Station (ISS). This nighttime view of the British capital shows the city’;s urban density and infrastructure as highlighted by electrical lighting. Beyond lie isolated bright areas marking the numerous smaller cities and towns of the region and as far southeast as Hastings on the coast. London’;s two major airports, Heathrow and Gatwick, are visible to the south of the city.

  5. Circles of Confidence in Correspondence: Modeling Confidentiality and Secrecy in Knowledge Exchange Networks of Letters and Drawings in the Early Modern Period.

    PubMed

    van den Heuvel, Charles; Weingart, Scott B; Spelt, Nils; Nellen, Henk

    2016-01-01

    Science in the early modern world depended on openness in scholarly communication. On the other hand, a web of commercial, political, and religious conflicts required broad measures of secrecy and confidentiality; similar measures were integral to scholarly rivalries and plagiarism. This paper analyzes confidentiality and secrecy in intellectual and technological knowledge exchange via letters and drawings. We argue that existing approaches to understanding knowledge exchange in early modern Europe--which focus on the Republic of Letters as a unified entity of corresponding scholars--can be improved upon by analyzing multilayered networks of communication. We describe a data model to analyze circles of confidence and cultures of secrecy in intellectual and technological knowledge exchanges. Finally, we discuss the outcomes of a first experiment focusing on the question of how personal and professional/official relationships interact with confidentiality and secrecy, based on a case study of the correspondence of Hugo Grotius.

  6. Michael Fisher at King's College London

    NASA Astrophysics Data System (ADS)

    Domb, Cyril

    1991-09-01

    Michael Fisher spent the first 16 years of his academic life in the Physics Department of King's College, London, starting as an undergraduate and ending as a full professor. A survey is undertaken of his activities and achievements during the various periods of this phase of his career.

  7. Michael Fisher at King's College London

    NASA Astrophysics Data System (ADS)

    Domb, Cyril

    Michael Fisher spent the first 16 years of his academic life in the Physics Department of King's College, London, starting as an undergraduate and ending as a full professor. A survey is undertaken of his activities and achievements during the various periods of this phase of his career.

  8. 75 FR 54024 - Drawbridge Operation Regulations; Shaw Cove, New London, CT, Maintenance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... Operation Regulations; Shaw Cove, New London, CT, Maintenance AGENCY: Coast Guard, DHS. ACTION: Notice of... temporary deviation from the regulation governing the operation of the Amtrak Bridge across Shaw Cove, mile...-9826. SUPPLEMENTARY INFORMATION: The Amtrak Bridge, across Shaw Cove at mile 0.0, at New London...

  9. Droughts and Dragons: Geography, Rainfall, and Eighteenth-Century London's Water Systems.

    PubMed

    Van Lieshout, Carry

    By the end of the eighteenth century the majority of households in London received a piped water supply. This article examines the geographical, technological, and environmental challenges that London's private water companies faced as they created and expanded the large technological networks necessary to provide the growing city's water supply. It identifies geography and drought as the main drivers of innovation in London's water supply neworks, and argues that the main impediment to expansion for the majority of the water companies was overcoming the differences in elevation between their intake points and customer bases, with major improvements often made as a result of water shortages. The timing and the success or failure of a company's technological improvements proved pivotal in the subsequent development of the water market.

  10. The London low emission zone baseline study.

    PubMed

    Kelly, Frank; Armstrong, Ben; Atkinson, Richard; Anderson, H Ross; Barratt, Ben; Beevers, Sean; Cook, Derek; Green, Dave; Derwent, Dick; Mudway, Ian; Wilkinson, Paul

    2011-11-01

    On February 4, 2008, the world's largest low emission zone (LEZ) was established. At 2644 km2, the zone encompasses most of Greater London. It restricts the entry of the oldest and most polluting diesel vehicles, including heavy-goods vehicles (haulage trucks), buses and coaches, larger vans, and minibuses. It does not apply to cars or motorcycles. The LEZ scheme will introduce increasingly stringent Euro emissions standards over time. The creation of this zone presented a unique opportunity to estimate the effects of a stepwise reduction in vehicle emissions on air quality and health. Before undertaking such an investigation, robust baseline data were gathered on air quality and the oxidative activity and metal content of particulate matter (PM) from air pollution monitors located in Greater London. In addition, methods were developed for using databases of electronic primary-care records in order to evaluate the zone's health effects. Our study began in 2007, using information about the planned restrictions in an agreed-upon LEZ scenario and year-on-year changes in the vehicle fleet in models to predict air pollution concentrations in London for the years 2005, 2008, and 2010. Based on this detailed emissions and air pollution modeling, the areas in London were then identified that were expected to show the greatest changes in air pollution concentrations and population exposures after the implementation of the LEZ. Using these predictions, the best placement of a pollution monitoring network was determined and the feasibility of evaluating the health effects using electronic primary-care records was assessed. To measure baseline pollutant concentrations before the implementation of the LEZ, a comprehensive monitoring network was established close to major roadways and intersections. Output-difference plots from statistical modeling for 2010 indicated seven key areas likely to experience the greatest change in concentrations of nitrogen dioxide (NO2) (at least 3

  11. Neighbourhoods and self rated health: a comparison of public sector employees in London and Helsinki

    PubMed Central

    Stafford, M.; Martikainen, P.; Lahelma, E.; Marmot, M.

    2004-01-01

    Study objective: Mortality and morbidity vary across neighbourhoods and larger residential areas. Effects of area deprivation on health may vary across countries, because of greater spatial separation of people occupying high and low socioeconomic positions and differences in the provision of local services and facilities. Neighbourhood variations in health and the contribution of residents' characteristics and neighbourhood indicators were compared in London and Helsinki, two settings where inequality and welfare policies differ. Design: Data from two cohorts were used to investigate associations between self rated health and neighbourhood indicators using a multilevel approach. Setting: London and Helsinki. Participants: From the Whitehall II study (London, aged 39–63) and the Helsinki health study (aged 40–60). Main results: Socioeconomic segregation was higher in London than in Helsinki. Age and sex adjusted differences in self rated health between neighbourhoods were also greater in London. Independent of individual socioeconomic position, neighbourhood unemployment, proportion of residents in manual occupations, and proportion of single households were associated with health. In pooled data, residence in a neighbourhood with highest unemployment was associated with an odds ratio of less than good self rated health of 1.51 (95% CI 1.30 to 1.75). High rates of single parenthood were associated with health in London but not in Helsinki. Conclusions: Neighbourhood socioeconomic context was associated with health in both countries, with some evidence of greater neighbourhood effects in London. Greater socioeconomic segregation in London may have emergent effects at the neighbourhood level. Local and national social policies may reduce, or restrict, inequality and segregation between areas. PMID:15310804

  12. Movement and Character. Lecture, London, 1946

    ERIC Educational Resources Information Center

    Montesorri, Maria

    2013-01-01

    Dr. Montessori's words from the 1946 London Lectures describe principles of intelligence and character, the work of the hand, and movement with a purpose as being integral to self-construction. The perfection of movement is spiritual, says Dr. Montessori. Repetition of practical life exercises are exercises in movement with the dignity of human…

  13. London Took the Lead: Institutes for Women.

    ERIC Educational Resources Information Center

    Hughes, Mary

    1992-01-01

    The creation in London of single-sex institutes for the education of women offered increased educational opportunities but did not widen their horizons. For working class women, educational policy regarding these institutes tended to support their domestic roles. (SK)

  14. Sex-related risks of trauma in medieval to early modern Denmark, and its relationship to change in interpersonal violence over time.

    PubMed

    Milner, G R; Boldsen, J L; Weise, S; Lauritsen, J M; Freund, U H

    2015-06-01

    Skeletons from three Danish cemeteries, Sortebrødre, Tirup, and St. Mikkel, that collectively held 822 adults (>15 years) and spanned the medieval to early modern periods (ca. AD 1100-1610) show that men, in general, experienced more bone fractures than women. Men were three times more likely to have healed cranial vault and ulnar shaft fractures than women, with many of these bones presumably broken in interpersonal violence. More women, however, broke distal radii, presumably often the result of falls. Both sexes suffered more cranial fractures than modern Danes, with the proportional difference for men and women being about the same. The difference in cranial trauma frequencies between historic-period and modern Danes has implications for a decline over the past several centuries in interpersonal violence that scholars in other disciplines have inferred from historical sources. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. ‘To[o] much eating stifles the child’: fat bodies and reproduction in early modern England†

    PubMed Central

    Toulalan, Sarah

    2013-01-01

    Abstract This article examines associations between fat bodies and reproductive dysfunction that were prevalent in medical, midwifery and other literature in early modern England. In a period when fertility and successful reproduction were regarded as hugely important for social, economic and political stability such associations further contributed to negative attitudes towards fat bodies that were fuelled by connection with the vices of sloth and gluttony. Fat bodies were categorized as inherently, constitutionally, less sexual and reproductively successful. Consequently they were perceived as unhealthy and unfit for their primary purpose once they had reached sexual maturity: marriage and the production of children. PMID:25960608

  16. To Moscow with love: partial reconstruction of Vygotsky's trip to London.

    PubMed

    van der Veer, René; Zavershneva, Ekaterina

    2011-12-01

    The Russian psychologist Lev Vygotsky (1896-1934) left the Soviet Union only once to attend a conference on the education of the deaf in London. So far almost nothing was known about this trip, which took place in a period when Vygotsky was still completely unknown as a psychologist, both inside his own country and abroad. Making use of a newly discovered notebook, it proved possible to partially reconstruct Vygotsky's journey and stay in London. Vygotsky's very personal remarks show him to have been a very sensitive and spirited man, who was prey to strong emotions during the conference and afterwards. Rather surprisingly, Vygotsky's own paper about the education of the deaf was never presented during the conference and the stay in London appears to have had a limited value for his own scientific development.

  17. Preventing suicide on the London Underground.

    PubMed

    Clarke, R V; Poyner, B

    1994-02-01

    A field study was carried out to investigate the possibility of preventing suicide on the London Underground. Four groups of potentially valuable measures were identified with the objectives of: (i) reducing public access to the tracks; (ii) improving surveillance by station staff; (iii) facilitating emergency stops; and (iv) reducing injury. These strategies are discussed.

  18. Psychoanalysis of Jack London's "The Call of the Wild" and "White Fang"

    ERIC Educational Resources Information Center

    Yang, Hongyan

    2015-01-01

    "The Call of the Wild" and "White Fang" both are masterpieces of Jack London. The protagonists Buck and White Fang are the incarnation of Jack himself to some extent for the two novels reveal a great deal of the writer. This essay aims at psychoanalyzing Jack London's creative process, the Oedipus complex and the confliction…

  19. Low on the London Scale

    NASA Astrophysics Data System (ADS)

    Webb, S.

    2013-09-01

    Until relatively recently, many authors have assumed that if extraterrestrial life is discovered it will be via the discovery of extraterrestrial intelligence: we can best try to detect life by adopting the SETI approach of trying to detect beacons or artefacts. The Rio Scale, proposed by Almár and Tarter in 2000, is a tool for quantifying the potential significance for society of any such reported detection. However, improvements in technology and advances in astrobiology raise the possibility that the discovery of extraterrestrial life will instead be via the detection of atmospheric biosignatures. The London Scale, proposed by Almár in 2010, attempts to quantify the potential significance of the discovery of extraterrestrial life rather than extraterrestrial intelligence. What might be the consequences of the announcement of a discovery that ranks low on the London Scale? In other words, what might be society's reaction if 'first contact' is via the remote sensing of the byproducts of unicellular organisms rather than with the products of high intelligence? Here, I examine some possible reactions to that question; in particular, I discuss how such an announcement might affect our views of life here on Earth and of humanity's place in the universe.

  20. Expanding women's rural medical work in early modern Brittany: the Daughters of the Holy Spirit.

    PubMed

    McHugh, Tim

    2012-07-01

    During the eighteenth century, orders of nursing sisters took on an expanded role in the rural areas of Brittany. This article explores the impact of religious change on the medical activities of these women. While limits were placed on the medical practice of unlicensed individuals, areas of new opportunity for nuns as charitable practitioners were created by devout nobles throughout the eighteenth century. These nuns provided comprehensive care for the sick poor on their patrons' estates, acting not only as nurses, but also in lieu of physicians, surgeons, and apothecaries. This article argues that the medical knowledge and expertise of these sisters from the nursing orders were highly valued by the elites of early modern Brittany.

  1. Expanding Women's Rural Medical Work in Early Modern Brittany: The Daughters of the Holy Spirit

    PubMed Central

    McHugh, Tim

    2012-01-01

    During the eighteenth century, orders of nursing sisters took on an expanded role in the rural areas of Brittany. This article explores the impact of religious change on the medical activities of these women. While limits were placed on the medical practice of unlicensed individuals, areas of new opportunity for nuns as charitable practitioners were created by devout nobles throughout the eighteenth century. These nuns provided comprehensive care for the sick poor on their patrons' estates, acting not only as nurses, but also in lieu of physicians, surgeons, and apothecaries. This article argues that the medical knowledge and expertise of these sisters from the nursing orders were highly valued by the elites of early modern Brittany. PMID:21724643

  2. Recent origin of low trabecular bone density in modern humans

    PubMed Central

    Chirchir, Habiba; Kivell, Tracy L.; Ruff, Christopher B.; Hublin, Jean-Jacques; Carlson, Kristian J.; Zipfel, Bernhard; Richmond, Brian G.

    2015-01-01

    Humans are unique, compared with our closest living relatives (chimpanzees) and early fossil hominins, in having an enlarged body size and lower limb joint surfaces in combination with a relatively gracile skeleton (i.e., lower bone mass for our body size). Some analyses have observed that in at least a few anatomical regions modern humans today appear to have relatively low trabecular density, but little is known about how that density varies throughout the human skeleton and across species or how and when the present trabecular patterns emerged over the course of human evolution. Here, we test the hypotheses that (i) recent modern humans have low trabecular density throughout the upper and lower limbs compared with other primate taxa and (ii) the reduction in trabecular density first occurred in early Homo erectus, consistent with the shift toward a modern human locomotor anatomy, or more recently in concert with diaphyseal gracilization in Holocene humans. We used peripheral quantitative CT and microtomography to measure trabecular bone of limb epiphyses (long bone articular ends) in modern humans and chimpanzees and in fossil hominins attributed to Australopithecus africanus, Paranthropus robustus/early Homo from Swartkrans, Homo neanderthalensis, and early Homo sapiens. Results show that only recent modern humans have low trabecular density throughout the limb joints. Extinct hominins, including pre-Holocene Homo sapiens, retain the high levels seen in nonhuman primates. Thus, the low trabecular density of the recent modern human skeleton evolved late in our evolutionary history, potentially resulting from increased sedentism and reliance on technological and cultural innovations. PMID:25535354

  3. Recent origin of low trabecular bone density in modern humans.

    PubMed

    Chirchir, Habiba; Kivell, Tracy L; Ruff, Christopher B; Hublin, Jean-Jacques; Carlson, Kristian J; Zipfel, Bernhard; Richmond, Brian G

    2015-01-13

    Humans are unique, compared with our closest living relatives (chimpanzees) and early fossil hominins, in having an enlarged body size and lower limb joint surfaces in combination with a relatively gracile skeleton (i.e., lower bone mass for our body size). Some analyses have observed that in at least a few anatomical regions modern humans today appear to have relatively low trabecular density, but little is known about how that density varies throughout the human skeleton and across species or how and when the present trabecular patterns emerged over the course of human evolution. Here, we test the hypotheses that (i) recent modern humans have low trabecular density throughout the upper and lower limbs compared with other primate taxa and (ii) the reduction in trabecular density first occurred in early Homo erectus, consistent with the shift toward a modern human locomotor anatomy, or more recently in concert with diaphyseal gracilization in Holocene humans. We used peripheral quantitative CT and microtomography to measure trabecular bone of limb epiphyses (long bone articular ends) in modern humans and chimpanzees and in fossil hominins attributed to Australopithecus africanus, Paranthropus robustus/early Homo from Swartkrans, Homo neanderthalensis, and early Homo sapiens. Results show that only recent modern humans have low trabecular density throughout the limb joints. Extinct hominins, including pre-Holocene Homo sapiens, retain the high levels seen in nonhuman primates. Thus, the low trabecular density of the recent modern human skeleton evolved late in our evolutionary history, potentially resulting from increased sedentism and reliance on technological and cultural innovations.

  4. 'Care and Prevent': rationale for investigating skin and soft tissue infections and AA amyloidosis among people who inject drugs in London.

    PubMed

    Harris, M; Brathwaite, R; McGowan, Catherine R; Ciccarone, D; Gilchrist, G; McCusker, M; O'Brien, K; Dunn, J; Scott, J; Hope, V

    2018-05-08

    Skin and soft tissue infections (SSTIs) are a leading cause of morbidity and mortality among people who inject drugs (PWID). International data indicate up to one third of PWID have experienced an SSTI within the past month. Complications include sepsis, endocarditis and amyloid A (AA) amyloidosis. AA amyloidosis is a serious sequela of chronic SSTI among PWID. Though there is a paucity of literature reporting on AA amyloidosis among PWID, what has been published suggests there is likely a causal relationship between AA amyloidosis and injecting-related SSTI. If left untreated, AA amyloidosis can lead to renal failure; premature mortality among diagnosed PWID is high. Early intervention may reverse disease. Despite the high societal and individual burden of SSTI among PWID, empirical evidence on the barriers and facilitators to injecting-related SSTI prevention and care or the feasibility and acceptability of AA amyloidosis screening and treatment referral are limited. This study aims to fill these gaps and assess the prevalence of AA amyloidosis among PWID. Care and Prevent is a UK National Institute for Health Research-funded mixed-methods study. In five phases (P1-P5), we aim to assess the evidence for AA amyloidosis among PWID (P1); assess the feasibility of AA amyloidosis screening, diagnostic and treatment referral among PWID in London (P2); investigate the barriers and facilitators to AA amyloidosis care (P3); explore SSTI protection and risk (P4); and co-create harm reduction resources with the affected community (P5). This paper describes the conceptual framework, methodological design and proposed analysis for the mixed-methods multi-phase study. We are implementing the Care and Prevent protocol in London. The systematic review component of the study has been completed and published. Care and Prevent will generate an estimate of AA amyloidosis prevalence among community recruited PWID in London, with implications for the development of screening

  5. Tracer concentration profiles measured in central London as part of the REPARTEE campaign

    NASA Astrophysics Data System (ADS)

    Martin, D.; Petersson, K. F.; White, I. R.; Henshaw, S. J.; Nickless, G.; Lovelock, A.; Barlow, J. F.; Dunbar, T.; Wood, C. R.; Shallcross, D. E.

    2011-01-01

    There have been relatively few tracer experiments carried out that have looked at vertical plume spread in urban areas. In this paper we present results from two tracer (cyclic perfluorocarbon) experiments carried out in 2006 and 2007 in central London centred on the BT Tower as part of the REPARTEE (Regent's Park and Tower Environmental Experiment) campaign. The height of the tower gives a unique opportunity to study vertical dispersion profiles and transport times in central London. Vertical gradients are contrasted with the relevant Pasquill stability classes. Estimation of lateral advection and vertical mixing times are made and compared with previous measurements. Data are then compared with a simple operational dispersion model and contrasted with data taken in central London as part of the DAPPLE campaign. This correlates dosage with non-dimensionalised distance from source. Such analyses illustrate the feasibility of the use of these empirical correlations over these prescribed distances in central London.

  6. Launch of the London Centre for Nanotechnology.

    PubMed

    Aeppli, Gabriel; Pankhurst, Quentin

    2006-12-01

    Is nanomedicine an area with the promise that its proponents claim? Professors Gabriel Aeppli and Quentin Pankhurst explore the issues in light of the new London Centre for Nanotechnology (LCN)--a joint enterprise between Imperial College and University College London--opened on November 7, 2006. The center is a multidisciplinary research initiative that aims to bridge the physical, engineering and biomedical sciences. In this interview, Professor Gabriel Aeppli, LCN co-Director, and Deputy Director Professor Quentin Pankhurst discuss the advent and future role of the LCN with Nanomedicine's Morag Robertson. Professor Aeppli was formerly with NEC, Bell Laboratories and MIT and has more than 15 years' experience in the computer and telecommunications industry. Professor Pankhurst is a physicist with more than 20 years' experience of working with magnetic materials and nanoparticles, who now works closely with clinicians and medics on innovative healthcare applications. He also recently formed the new start-up company Endomagnetics Inc.

  7. Stuart London's standard of living: re-examining the Settlement of Tithes of 1638 for rents, income, and poverty.

    PubMed

    Baer, William C

    2010-01-01

    The Settlement of Tithes of 1638 can be tested for biases in its London rents. Even so, it proves to be a relatively good source for seventeenth-century London, and for calculating associated median and mean rents, as well as a Gini coefficient of inequality for the distribution of resources. Through other evidence in the Settlement, rent/income ratios for London can be approximated, and from them estimates made of London's median income. Median rents and income also allow estimates of the percentage of Londoners in poverty. Though the last is inevitably disputable, the estimate holds up well to testing by other evidence.

  8. London through Rose-Colored Graphics: Visual Rhetoric and Information Graphic Design in Charles Booth's Maps of London Poverty

    ERIC Educational Resources Information Center

    Kimball, Miles A.

    2006-01-01

    In this article, I examine a historical information graphic--Charles Booth's maps of London poverty (1889-1902)--to analyze the cultural basis of ideas of transparency and clarity in information graphics. I argue that Booth's maps derive their rhetorical power from contemporary visual culture as much as from their scientific authority. The visual…

  9. Composition of Façon de Venise glass from early 17th century London in comparison with luxury glass of the same age

    NASA Astrophysics Data System (ADS)

    Cagno, S.; De Raedt, I.; Jeffries, T.; Janssens, K.

    SEM-EDX and LA-ICP-MS analyses were performed on a set of early 17th century London glass fragments. The samples originate from two archaeological sites (Aldgate and Old Broad Street) where glass workshops were active in this period. The great majority of the samples are made of soda glass. Two distinct compositional groups are observed, each typical of one site of provenance. The samples originating from the Old Broad Street excavation feature a silica-soda-lime composition, with a moderate amount of potash. The samples from Aldgate are richer in potassium and feature higher amounts of trace elements such as Rb, Zr and Cu. The distinction between the two groups stems from different flux and silica sources used for glassmaking. A comparison with different European glass compositions of that time reveals no resemblance with genuine Venetian production, yet the composition of the Old Broad Street glass shows a close similarity to that of fragments produced `à la façon de Venise' in Antwerp at the end of the 16th century. This coincides with historical sources attesting the arrival of glassworkers from the Low Countries in England and suggests that a transfer of technology took place near the turn of the century.

  10. Limited urban growth: London's street network dynamics since the 18th century.

    PubMed

    Masucci, A Paolo; Stanilov, Kiril; Batty, Michael

    2013-01-01

    We investigate the growth dynamics of Greater London defined by the administrative boundary of the Greater London Authority, based on the evolution of its street network during the last two centuries. This is done by employing a unique dataset, consisting of the planar graph representation of nine time slices of Greater London's road network spanning 224 years, from 1786 to 2010. Within this time-frame, we address the concept of the metropolitan area or city in physical terms, in that urban evolution reveals observable transitions in the distribution of relevant geometrical properties. Given that London has a hard boundary enforced by its long standing green belt, we show that its street network dynamics can be described as a fractal space-filling phenomena up to a capacitated limit, whence its growth can be predicted with a striking level of accuracy. This observation is confirmed by the analytical calculation of key topological properties of the planar graph, such as the topological growth of the network and its average connectivity. This study thus represents an example of a strong violation of Gibrat's law. In particular, we are able to show analytically how London evolves from a more loop-like structure, typical of planned cities, toward a more tree-like structure, typical of self-organized cities. These observations are relevant to the discourse on sustainable urban planning with respect to the control of urban sprawl in many large cities which have developed under the conditions of spatial constraints imposed by green belts and hard urban boundaries.

  11. Health effects of the London bicycle sharing system: health impact modelling study.

    PubMed

    Woodcock, James; Tainio, Marko; Cheshire, James; O'Brien, Oliver; Goodman, Anna

    2014-02-13

    To model the impacts of the bicycle sharing system in London on the health of its users. Health impact modelling and evaluation, using a stochastic simulation model. Central and inner London, England. Total population operational registration and usage data for the London cycle hire scheme (collected April 2011-March 2012), surveys of cycle hire users (collected 2011), and London data on travel, physical activity, road traffic collisions, and particulate air pollution (PM2.5, (collected 2005-12). 578,607 users of the London cycle hire scheme, aged 14 years and over, with an estimated 78% of travel time accounted for by users younger than 45 years. Change in lifelong disability adjusted life years (DALYs) based on one year impacts on incidence of disease and injury, modelled through medium term changes in physical activity, road traffic injuries, and exposure to air pollution. Over the year examined the users made 7.4 million cycle hire trips (estimated 71% of cycling time by men). These trips would mostly otherwise have been made on foot (31%) or by public transport (47%). To date there has been a trend towards fewer fatalities and injuries than expected on cycle hire bicycles. Using these observed injury rates, the population benefits from the cycle hire scheme substantially outweighed harms (net change -72 DALYs (95% credible interval -110 to -43) among men using cycle hire per accounting year; -15 (-42 to -6) among women; note that negative DALYs represent a health benefit). When we modelled cycle hire injury rates as being equal to background rates for all cycling in central London, these benefits were smaller and there was no evidence of a benefit among women (change -49 DALYs (-88 to -17) among men; -1 DALY (-27 to 12) among women). This sex difference largely reflected higher road collision fatality rates for female cyclists. At older ages the modelled benefits of cycling were much larger than the harms. Using background injury rates in the youngest age

  12. The stranded individualizer under compressed modernity: South Korean women in individualization without individualism.

    PubMed

    Kyung-Sup, Chang; Min-Young, Song

    2010-09-01

    South Korean families have functioned as a highly effective receptacle for the country's highly compressed conditions of modernity and late modernity. It is as much due to the success of South Korean families as an engine of compressed modernity as due to their failure that they have become functionally overloaded and socially risk-ridden. Such familial burdens and risks are particularly onerous to South Korean women because of the fundamentally gender-based structure of family relations and duties that has in part been recycled from the Confucian past and in part manufactured under industrial capitalism. Under these complicated conditions, South Korean women have had to dramatically restructure their family relations and duties as well as their individual life choices. Furthermore, under the most recent condition of what Beck calls second modernity, other institutions of modernity, such as the state, industrial economy, firms, unions, schools, and welfare systems, have become increasingly ineffective in helping to alleviate such (gender-based) familial burdens and dilemmas. As a result South Korean women have experienced dramatic changes in marriage patterns, fertility, family relations, etc. South Korean women's individualization has thereby taken place primarily as a matter of practicality rather than ideational change. A brief analysis of the situation in the neighbouring societies of Japan and Taiwan reinforces the conclusion that individualization without individualism, particularly among women, is a region-wide phenomenon in East Asia. © London School of Economics and Political Science 2010.

  13. The Evolution of Modern Dance Therapy.

    ERIC Educational Resources Information Center

    Levy, Fran

    1988-01-01

    The article traces the impact of the modern dance movement from the early 1900s and its emphasis on creativity and self-expression on the professional and institutional development of dance therapy. (CB)

  14. Evolving Pb isotope signatures of London airborne particulate matter (PM 10)-constraints from on-filter and solution-mode MC-ICP-MS.

    PubMed

    Noble, Stephen R; Horstwood, Matthew S A; Davy, Pamela; Pashley, Vanessa; Spiro, Baruch; Smith, Steve

    2008-07-01

    Pb isotope compositions of biologically significant PM(10) atmospheric particulates from a busy roadside location in London UK were measured using solution- and laser ablation-mode MC-ICP-MS. The solution-mode data for PM(10) sampled between 1998-2001 document a dramatic shift to increasingly radiogenic compositions as leaded petrol was phased out. LA-MC-ICP-MS isotope analysis, piloted on a subset of the available samples, is shown to be a potential reconnaissance analytical technique. PM(10) particles trapped on quartz filters were liberated from the filter surface, without ablating the filter substrate, using a 266 nm UV laser and a dynamic, large diameter, low-fluence ablation protocol. The Pb isotope evolution noted in the London data set obtained by both analytical protocols is similar to that observed elsewhere in Western Europe following leaded petrol elimination. The data therefore provide important baseline isotope composition information useful for continued UK atmospheric monitoring through the early 21(st) century.

  15. Ultimate concerns in late modernity: Archer, Bourdieu and reflexivity.

    PubMed

    Farrugia, David; Woodman, Dan

    2015-12-01

    Through a critique of Margaret Archer's theory of reflexivity, this paper explores the theoretical contribution of a Bourdieusian sociology of the subject for understanding social change. Archer's theory of reflexivity holds that conscious 'internal conversations' are the motor of society, central both to human subjectivity and to the 'reflexive imperative' of late modernity. This is established through critiques of Bourdieu, who is held to erase creativity and meaningful personal investments from subjectivity, and late modernity is depicted as a time when a 'situational logic of opportunity' renders embodied dispositions and the reproduction of symbolic advantages obsolete. Maintaining Archer's focus on 'ultimate concerns' in a context of social change, this paper argues that her theory of reflexivity is established through a narrow misreading and rejection of Bourdieu's work, which ultimately creates problems for her own approach. Archer's rejection of any pre-reflexive dimensions to subjectivity and social action leaves her unable to sociologically explain the genesis of 'ultimate concerns', and creates an empirically dubious narrative of the consequences of social change. Through a focus on Archer's concept of 'fractured reflexivity', the paper explores the theoretical necessity of habitus and illusio for understanding the social changes that Archer is grappling with. In late modernity, reflexivity is valorized just as the conditions for its successful operation are increasingly foreclosed, creating 'fractured reflexivity' emblematic of the complex contemporary interaction between habitus, illusio, and accelerating social change. © London School of Economics and Political Science 2015.

  16. Seeing Ourselves as Others See Us: Egyptian Teachers' Views of Science Education in Secondary Schools in London, UK.

    ERIC Educational Resources Information Center

    Swain, Julian; Monk, Martin; Johnson, Sally

    1999-01-01

    Explores Egyptian science teachers' views of (1) science education in London secondary schools and (2) how London schools influenced their teaching in Egypt. Explains that the Egyptian teachers were participating in a 12-week in-service course at King's College, London. Discusses the results. (CMK)

  17. Eddy Covariance Measurements Assessing NOx Emission in London, UK

    NASA Astrophysics Data System (ADS)

    Drysdale, W. S.; Lee, J. D.; Purvis, R.; Squires, F. A.; Vaughan, A. R.; Metzger, S.

    2017-12-01

    NOx (the sum of NO + NO2) is emitted during most combustion processes. NO2is a well known air pollutant detrimental to human health, and is regulated in many cities. London often finds itself in breach of these emission regulations. Emission inventories are used in air quality forecast models to predict current and future air pollution levels and to guide abatement strategy. It is therefore crucial that inventories accurately predict emissions; validation can be carried out using direct measurements. Measurements of NO and NO2 at 5 Hz have been made at the BT Tower, 190 m above street level in central London. Eddy covariance calculations have been performed using both classical and "continuous wavelet transformation" method, producing half hour and 1 minute resolved NOx fluxes respectively. We present a first look at these flux data measured in early 2017. A strong diurnal profile for NOx flux is observed, with an increase from 5am to 7am, and remaining constant around 1400 ng m2 m-1 throughout the day, before decreasing to background levels towards midnight. Data is also compared to previous NOx flux measurements over two periods, June-July 2012 and March-April 2013 to examine how emissions have changed over this period. A significant decrease in NOx emissions ( 64%, a mean flux of 2400 ng m2 s-1 in 2012 to a mean 870 ng m2 s-1 in 2017) is observed. When the fluxes are separated by wind flow from the east and west, there is negligible difference in 2017, where 2012 saw lower fluxes from the east, especially in the afternoon. By coupling the measurements with a footprint model we compare the data to emission estimates from the UK's National Atmospheric Emission Inventory (NAEI). In 2012-13 emissions were measured to be twice as high than the NAEI predicted and the latest data shows a much better agreement.

  18. Presence of Legionella in London's water supplies.

    PubMed

    Colbourne, J S; Trew, R M

    1986-09-01

    Legionella occurs frequently (52 to 54%) in domestic water and cooling water inside commercial, industrial and health care buildings, and these types of water systems are now regarded as a normal habitat for Legionella. The factors that predispose a particular water system to colonization by these organisms are ill-defined, although it is fairly certain that biological and physicochemical environmental factors play an important role in allowing Legionella to multiply in the circulating water. It has been postulated that the organism may gain access to water systems inside buildings by one of three routes: contact with air through open points such as uncovered storage tanks or vents, ingress of soil or surface water during construction or repair, or intermittent seeding with organisms present in low numbers in the public water supply. Three studies in the USA have found Legionella in 0.4 to 8.8% of drinking-water samples, but these were not representative of the public supply network as a whole. The aim of this study was to determine, over a period of 1 year, the frequency of Legionella in London's drinking water--from the treatment plant through to the consumer's tap. To date, Legionella has not been isolated from raw river water entering London's treatment works or from treated water entering the distribution network. Sixty-two monitoring taps in buildings located in 21 supply areas have been sampled twice for Legionella; only 2 (2.4%) have proved positive during the autumn and winter of 1985/86. The strain found was L. pneumophila serotype 1, subgroup Olda, and the numbers ranged from 10(2) to 10(4)/l. Although the survey is incomplete, it is already clear that the public water supplies in London are not a source of strains of Legionella associated with disease.

  19. Mind the gap: financial London and the regional class pay gap.

    PubMed

    Friedman, Sam; Laurison, Daniel

    2017-09-01

    The hidden barriers, or 'gender pay gap', preventing women from earning equivalent incomes to men is well documented. Yet recent research has uncovered that, in Britain, there is also a comparable class-origin pay gap in higher professional and managerial occupations. So far this analysis has only been conducted at the national level and it is not known whether there are regional differences within the UK. This paper uses pooled data from the 2014 and 2015 Labour Force Survey (N = 7,534) to stage a more spatially sensitive analysis that examines regional variation in the class pay gap. We find that this 'class ceiling' is not evenly spatially distributed. Instead it is particularly marked in Central London, where those in high-status occupations who are from working-class backgrounds earn, on average, £10,660 less per year than those whose parents were in higher professional and managerial employment. Finally, we inspect the Capital further to reveal that the class pay gap is largest within Central London's banking and finance sector. Challenging policy conceptions of London as the 'engine room' of social mobility, these findings suggest that class disadvantage within high-status occupations is particularly acute in the Capital. The findings also underline the value of investigating regional differences in social mobility, and demonstrate how such analysis can unravel important and previously unrecognized spatial dimensions of class inequality. © London School of Economics and Political Science 2017.

  20. School bullying and traumatic dental injuries in East London adolescents.

    PubMed

    Agel, M; Marcenes, W; Stansfeld, S A; Bernabé, E

    2014-12-01

    To explore the association between school bullying and traumatic dental injuries (TDI) among 15-16-year-old school children from East London. Data from phase III of the Research with East London Adolescents Community Health Survey (RELACHS), a school-based prospective study of a representative sample of adolescents, were analysed. Adolescents provided information on demographic characteristics, socioeconomic measures and frequency of bullying in school through self-administered questionnaires and were clinically examined for overjet, lip coverage and TDI. The association between school bullying and TDI was assessed using binary logistic regression models. The prevalence of TDI was 17%, while lifetime and current prevalence of bullying was 32% and 11%, respectively. The prevalence of TDI increased with a growing frequency of bullying; from 16% among adolescents who had never been bullied at school, to 21% among those who were bullied in the past but not this school term, to 22% for those who were bullied this school term. However, this association was not statistically significant either in crude or adjusted regression models. There was no evidence of an association between frequency of school bullying and TDI in this sample of 15-16-year-old adolescents in East London.

  1. Diversity in Adoption of Linguistic Features of London English by Chinese and Bangladeshi Adolescents

    ERIC Educational Resources Information Center

    Pennington, Martha C.; Lau, Lawrence; Sachdev, Itesh

    2011-01-01

    This comparative study, conducted in multicultural London, investigates the occurrence in interviews with a researcher and in constructed same-sex peer conversations of five linguistic features characteristic of London English in the speech of two groups of British-born adolescents: ethnic Bangladeshis and ethnic Chinese of Cantonese heritage. The…

  2. Safety and security in acute admission psychiatric wards in Ireland and London: a comparative study.

    PubMed

    Cowman, Seamus; Bowers, Len

    2009-05-01

    The comparative element of this study is to describe safety and security measures in psychiatric acute admission wards in the Republic of Ireland and London; to describe differences and similarities in terms of safety and security patterns in the Republic of Ireland and London; and to make recommendations on safety and security to mental health services management and psychiatric nurses. Violence is a serious problem in psychiatric services and staff experience significant psychological reactions to being assaulted. Health and Safety Authorities in the UK and Ireland have expressed concern about violence and assault in healthcare, however, there remains a lack of clarity on matters of procedure and policy pertaining to safety and security in psychiatric hospitals. A descriptive survey research design was employed. Questionnaires were circulated to all acute wards in London and in Ireland and the resulting data compared. A total of 124 psychiatric wards from London and 43 wards from Ireland were included in this study and response rates of 70% (London) and 86% (Ireland) were obtained. Differences and similarities in safety and security practices were identified between London and Ireland, with Irish wards having generally higher and more intensive levels of security. There is a lack of coherent policy and procedure in safety and security measures across psychiatric acute admission wards in the Republic of Ireland and London. Given the trends in European Union (EU) regulation, there is a strong argument for the publication of acceptable minimum guidelines for safety and security in mental health services across the EU. There must be a concerted effort to ensure that all policy and procedure in safety and security is founded on evidence and best practice. Mental health managers must establish a review of work safety and security procedures and practices. Risk assessment and environmental audits of all mental health clinical environments should be mandatory.

  3. The New Education and the Institute of Education, University of London, 1919-1945

    ERIC Educational Resources Information Center

    Aldrich, Richard

    2009-01-01

    The London Day Training College (LDTC), founded in 1902, soon became the leading institution for the study of education and for the training of teachers in England. In 1932 it was transmuted into the Institute of Education of the University of London. Its title and pre-eminence have continued to this day. In the period 1919-1945 it was closely,…

  4. Demons, nature, or God? Witchcraft accusations and the French disease in early modern Venice.

    PubMed

    McGough, Laura J

    2006-01-01

    In early modern Venice, establishing the cause of a disease was critical to determining the appropriate cure: natural remedies for natural illnesses, spiritual solutions for supernatural or demonic ones. One common ailment was the French disease (syphilis), widely distributed throughout Venice's neighborhoods and social hierarchy, and evenly distributed between men and women. The disease was widely regarded as curable by the mid-sixteenth century, and cases that did not respond to natural remedies presented problems of interpretation to physicians and laypeople. Witchcraft was one possible explanation; using expert testimony from physicians, however, the Holy Office ruled out witchcraft as a cause of incurable cases and reinforced perceptions that the disease was of natural origin. Incurable cases were explained as the result of immoral behavior, thereby reinforcing the associated stigma. This article uses archival material from Venice's Inquisition records from 1580 to 1650, as well as mortality data.

  5. Sherborn's foraminiferal studies and their influence on the collections at the Natural History Museum, London.

    PubMed

    Miller, C Giles

    2016-01-01

    Sherborn's work on the Foraminifera clearly provided the initial spark to compile the major indexes for which he is famous. Contact and help from famous early micropalaeontologists such as T. Rupert Jones and Fortescue William Millett led Sherborn to produce his Bibliography of Foraminifera and subsequently a two-part Index of Foraminiferal Genera and Species. Edward Heron-Allen, whose mentor was Millett, was subsequently inspired by the bibliography to attempt to acquire every publication listed. This remarkable collection of literature was donated to the British Museum (Natural History) in 1926 along with the foraminiferal collections Heron-Allen had mainly purchased from early micropalaeontologists. This donation forms the backbone of the current NHM micropalaeontological collections. The NHM collections contain a relatively small amount of foraminiferal material published by Sherborn from the London Clay, Kimmeridge Clay and Speeton Clay. Another smaller collection reflects his longer-term interest in the British Chalk following regular fieldwork with A. W. Rowe. Other collections relating to Sherborn's early published work, particularly with T. R. Jones, are not present in the collections but these collections may have been sold or deposited elsewhere by his co-workers.

  6. Assessing the sources and bioaccessibility of Lead in Soils from London

    NASA Astrophysics Data System (ADS)

    Cave, Mark R.; Wragg, Joanna; Chenery, Simon

    2013-04-01

    The lead content of soil is important since it is toxic to humans and particularly because children tend to more readily absorb lead than do adults: children absorb up to 40% into the bloodstream from ingested or inhaled lead, versus 5-15% in adults. Studies have shown that relatively low concentrations of lead in blood can lead to significant decrease in IQ of children (e.g. Jakubowski, 2011) leading to neuropathy and hypertension in adults. The British Geological Survey has recently completed a systematic high-density geochemical soil survey of the Greater London Area (GLA) in which over 6000 surface soil samples were collected and analysed for 50 elements. The Pb content of the soils range from 11 mg/kg to greater than 10000 mg/kg with mean and median values of 301 and 185 mg/kg, respectively. The ingestion bioaccessible fraction of Pb was measured using an in-vitro bioaccessibility test showing that 68% of the total Pb in London soils is bioaccessible. Measurement of Pb isotopic ratios in selected soils matched with those found in London air particulates and, to a lesser extent, with petrol lead. Self modelling mixture resolution of the 50 element geochemical data set was used to identify geochemically distinct components in the data with Pb being associated with 11 of the components which were of both natural and anthropogenic origin. Relationships between the soil components, the bioaccessible fraction and the Pb isotope ratios provided an indication of the sources of mobile lead in the London soils. References JAKUBOWSKI, M. 2011. Low-level environmental lead exposure and intellectual impairment in children - the current concepts of risk assessment. International Journal of Occupational Medicine and Environmental Health, Vol. 24, 1-7. APPLETON, J D, CAVE, M R, and WRAGG, J. 2012. Modelling lead bioaccessibility in urban topsoils based on data from Glasgow, London, Northampton and Swansea, UK. Environmental Pollution, Vol. 171, 265-272.

  7. Active Citizenship & Adult Learning In Inner London. Research Paper in Continuing Education Number 2.

    ERIC Educational Resources Information Center

    Payne, John

    The impact of the abolition of the Inner London Educational Authority (ILEA) on adult education in London (England) was explored. Specifically, the impact of abolition, that might support the concept and practice of active citizenship, was studied on three areas of adult education: environmental education, antiracist work, and work with voluntary…

  8. Knives and Other Weapons in London Schools

    ERIC Educational Resources Information Center

    Neill, S. R. St. J.

    2005-01-01

    London schools operate in an area where crime rates, including violent crime, is statistically more frequent than the average for the whole of England and Wales (Moore and Yeo 2004). Violent crime in the capital increased (though not to a statistically significant extent) between 2002/3 and 2003/4 (Moore and Yeo 2004b). This has led to a…

  9. Dentists with enhanced skills (Special Interest) in Endodontics: gatekeepers views in London.

    PubMed

    Ghotane, Swapnil G; Al-Haboubi, Mustafa; Kendall, Nick; Robertson, Claire; Gallagher, Jennifer E

    2015-09-21

    Dentists with a special interest hold enhanced skills enabling them to treat cases of intermediate complexity. The aim of this study was to explore primary dental care practitioners' views of dentists with a special interest (DwSIs) in Endodontics in London, with reference to an educational and service initiative established by (the former) London Deanery in conjunction with the NHS. A cross-sectional postal survey of primary care dentists working across different models of care within London was conducted, with a target to achieve views of at least 5 % of London's dentists. The questionnaire instrument was informed by qualitative research and the dental literature and piloted prior to distribution; data were analysed using SPSS v19 and STATA v12.0. Six per cent of London's primary care dentists (n = 243) responded to the survey; 53 % were male. Just over one third (37 %; n = 90) were aware of the DwSI service being provided. Most practitioners reported that having access to a DwSI in Endodontics would support the care of their patients (89 %; n = 215), would carry out more endodontic treatment in the NHS primary dental care if adequately reimbursed (93 %; n = 220), and had more time (76 %; n = 180). Female respondents appeared to be less confident in doing endodontic treatment (p = 0.001). More recently qualified respondents reported greater need for training/support for performing more endodontic treatment in the NHS primary dental care (p = 0.001), were more dissatisfied with access to endodontic service in the NHS primary dental care (p = 0.007) and more interested to train as a DwSI in endodontics (p = 0.001) compared with respondents having a greater number of years of clinical experience since qualification. The findings lend support to the concept of developing dentists with enhanced skills as well as ensuring additional funding, time and support to facilitate more routine endodontics through the NHS primary care to meet

  10. The First Modern Human Dispersals across Africa

    PubMed Central

    Rito, Teresa; Richards, Martin B.; Fernandes, Verónica; Alshamali, Farida; Cerny, Viktor

    2013-01-01

    The emergence of more refined chronologies for climate change and archaeology in prehistoric Africa, and for the evolution of human mitochondrial DNA (mtDNA), now make it feasible to test more sophisticated models of early modern human dispersals suggested by mtDNA distributions. Here we have generated 42 novel whole-mtDNA genomes belonging to haplogroup L0, the most divergent clade in the maternal line of descent, and analysed them alongside the growing database of African lineages belonging to L0’s sister clade, L1’6. We propose that the last common ancestor of modern human mtDNAs (carried by “mitochondrial Eve”) possibly arose in central Africa ~180 ka, at a time of low population size. By ~130 ka two distinct groups of anatomically modern humans co-existed in Africa: broadly, the ancestors of many modern-day Khoe and San populations in the south and a second central/eastern African group that includes the ancestors of most extant worldwide populations. Early modern human dispersals correlate with climate changes, particularly the tropical African “megadroughts” of MIS 5 (marine isotope stage 5, 135–75 ka) which paradoxically may have facilitated expansions in central and eastern Africa, ultimately triggering the dispersal out of Africa of people carrying haplogroup L3 ~60 ka. Two south to east migrations are discernible within haplogroup LO. One, between 120 and 75 ka, represents the first unambiguous long-range modern human dispersal detected by mtDNA and might have allowed the dispersal of several markers of modernity. A second one, within the last 20 ka signalled by L0d, may have been responsible for the spread of southern click-consonant languages to eastern Africa, contrary to the view that these eastern examples constitute relicts of an ancient, much wider distribution. PMID:24236171

  11. Using maps and funnel plots to explore variation in place of death from cancer within London, 2002-2007.

    PubMed

    Madden, P; Coupland, Vh; Møller, H; Davies, Ea

    2011-06-01

    London has a high proportion of hospital deaths, which health policy seeks to reduce. We explore variation and trends in place of death from cancer within London between 2002 and 2007. Mortality data based on death certificates were used to define deaths from cancer at home, hospice, hospital and nursing home and examine trends over time for London. Proportions of deaths in each place were presented in maps for 31 London primary care trusts (PCTs). Funnel plots were used to identify consistent performance outside the control limits of three standard deviations. There was little overall change in place of death for London, but consistent variation between PCTs. Outer London PCTs had higher proportions of home deaths and inner London PCTs higher proportions of hospice deaths. Funnel plots identified consistent high outlying performance for home, hospice and hospital deaths. No PCT showed a change of 10% or more in home deaths, but five showed decreasing hospital deaths and three increasing hospice deaths. Maps and funnel plots appear useful for identifying areas with differing performance for home, hospital, nursing home and hospice deaths. These methods may help further investigation of how local services may successfully support deaths outside hospital. © The Author(s) 2011

  12. Time-dependent London approach: Dissipation due to out-of-core normal excitations by moving vortices

    DOE PAGES

    Kogan, V. G.

    2018-03-19

    The dissipative currents due to normal excitations are included in the London description. The resulting time-dependent London equations are solved for a moving vortex and a moving vortex lattice. It is shown that the field distribution of a moving vortex loses its cylindrical symmetry. It experiences contraction that is stronger in the direction of the motion than in the direction normal to the velocity v. The London contribution of normal currents to dissipation is small relative to the Bardeen-Stephen core dissipation at small velocities, but it approaches the latter at high velocities, where this contribution is no longer proportional tomore » v 2. Here, to minimize the London contribution to dissipation, the vortex lattice is oriented so as to have one of the unit cell vectors along the velocity. This effect is seen in experiments and predicted within the time-dependent Ginzburg-Landau theory.« less

  13. Time-dependent London approach: Dissipation due to out-of-core normal excitations by moving vortices

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kogan, V. G.

    The dissipative currents due to normal excitations are included in the London description. The resulting time-dependent London equations are solved for a moving vortex and a moving vortex lattice. It is shown that the field distribution of a moving vortex loses its cylindrical symmetry. It experiences contraction that is stronger in the direction of the motion than in the direction normal to the velocity v. The London contribution of normal currents to dissipation is small relative to the Bardeen-Stephen core dissipation at small velocities, but it approaches the latter at high velocities, where this contribution is no longer proportional tomore » v 2. Here, to minimize the London contribution to dissipation, the vortex lattice is oriented so as to have one of the unit cell vectors along the velocity. This effect is seen in experiments and predicted within the time-dependent Ginzburg-Landau theory.« less

  14. Time-dependent London approach: Dissipation due to out-of-core normal excitations by moving vortices

    NASA Astrophysics Data System (ADS)

    Kogan, V. G.

    2018-03-01

    The dissipative currents due to normal excitations are included in the London description. The resulting time-dependent London equations are solved for a moving vortex and a moving vortex lattice. It is shown that the field distribution of a moving vortex loses its cylindrical symmetry. It experiences contraction that is stronger in the direction of the motion than in the direction normal to the velocity v . The London contribution of normal currents to dissipation is small relative to the Bardeen-Stephen core dissipation at small velocities, but it approaches the latter at high velocities, where this contribution is no longer proportional to v2. To minimize the London contribution to dissipation, the vortex lattice is oriented so as to have one of the unit cell vectors along the velocity. This effect is seen in experiments and predicted within the time-dependent Ginzburg-Landau theory.

  15. Characterizing Students' Mechanistic Reasoning about London Dispersion Forces

    ERIC Educational Resources Information Center

    Becker, Nicole; Noyes, Keenan; Cooper, Melanie

    2016-01-01

    Characterizing how students construct causal mechanistic explanations for chemical phenomena can provide us with important insights into the ways that students develop understanding of chemistry concepts. Here, we present two qualitative studies of undergraduate general chemistry students' reasoning about the causes of London dispersion forces in…

  16. Seasonal influenza vaccination delivery through community pharmacists in England: evaluation of the London pilot

    PubMed Central

    Atkins, Katherine; van Hoek, Albert Jan; Watson, Conall; Baguelin, Marc; Choga, Lethiwe; Patel, Anika; Raj, Thara; Jit, Mark; Griffiths, Ulla

    2016-01-01

    Objective To evaluate the effectiveness and cost of the pan-London pharmacy initiative, a programme that allows administration of seasonal influenza vaccination to eligible patients at pharmacies. Design We analysed 2013–2015 data on vaccination uptake in pharmacies via the Sonar reporting system, and the total vaccination uptake via 2011–2015 ImmForm general practitioner (GP) reporting system data. We conducted an online survey of London pharmacists who participate in the programme to assess time use data, vaccine choice, investment costs and opinions about the programme. We conducted an online survey of London GPs to assess vaccine choice of vaccine and opinions about the pharmacy vaccine delivery programme. Setting All London boroughs. Participants London-based GPs, and pharmacies that currently offer seasonal flu vaccination. Interventions Not applicable. Main outcome measures Comparison of annual vaccine uptake in London across risk groups from years before pharmacy vaccination introduction to after pharmacy vaccination introduction. Completeness of vaccine uptake reporting data. Cost to the National Health Service (NHS) of flu vaccine delivery at pharmacies with that at GPs. Cost to pharmacists of flu delivery. Opinions of pharmacists and GPs regarding the flu vaccine pharmacy initiative. Results No significant change in the uptake of seasonal vaccination in any of the risk groups as a result of the pharmacy initiative. While on average a pharmacy-administered flu vaccine dose costs the NHS up to £2.35 less than a dose administered at a GP, a comparison of the 2 recording systems suggests there is substantial loss of data. Conclusions Flu vaccine delivery through pharmacies shows potential for improving convenience for vaccine recipients. However, there is no evidence that vaccination uptake increases and the use of 2 separate recording systems leads to time-consuming data entry and missing vaccine record data. PMID:26883237

  17. Rasch analysis of the London Handicap Scale in stroke patients: a cross-sectional study.

    PubMed

    Park, Eun-Young; Choi, Yoo-Im

    2014-07-31

    Although activity and participation are the target domains in stroke rehabilitation interventions, there is insufficient evidence available regarding the validity of participation measurement. The purpose of this study was to investigate the psychometric properties of the London Handicap Scale in community-dwelling stroke patients, using Rasch analysis. Participants were 170 community-dwelling stroke survivors. The data were analyzed using Winsteps (version 3.62) with the Rasch model to determine the unidimensionality of item fit, the distribution of item difficulty, and the reliability and suitability of the rating process for the London Handicap Scale. Data of 16 participants did not fit the Rasch model and there were no misfitting items. The person separation value was 2.42, and the reliability was .85; furthermore, the rating process for the London Handicap Scale was found to be suitable for use with stroke patients. This was the first trial to investigate the psychometric properties of the London Handicap Scale using Rasch analysis; the results supported the suitability of this scale for use with stroke patients.

  18. Transnational Connections in Early Twentieth-Century Women Teachers' Work

    ERIC Educational Resources Information Center

    Whitehead, Kay

    2012-01-01

    Using a transnational framework, this paper focuses on four graduates of Gipsy Hill Training College (GHTC) for nursery school teachers in London, United Kingdom, in the early to mid-twentieth century. Firstly, I explore GHTC's progressive ideals and highlight ways in which its principal, Lillian de Lissa, encouraged students to "think…

  19. Earth's early biosphere

    NASA Technical Reports Server (NTRS)

    Des Marais, D. J.

    1998-01-01

    Understanding our own early biosphere is essential to our search for life elsewhere, because life arose on Earth very early and rocky planets shared similar early histories. The biosphere arose before 3.8 Ga ago, was exclusively unicellular and was dominated by hyperthermophiles that utilized chemical sources of energy and employed a range of metabolic pathways for CO2 assimilation. Photosynthesis also arose very early. Oxygenic photosynthesis arose later but still prior to 2.7 Ga. The transition toward the modern global environment was paced by a decline in volcanic and hydrothermal activity. These developments allowed atmospheric O2 levels to increase. The O2 increase created new niches for aerobic life, most notably the more advanced Eukarya that eventually spawned the megascopic fauna and flora of our modern biosphere.

  20. Curiosity, forbidden knowledge, and the reformation of natural philosophy in early modern England.

    PubMed

    Harrison, P

    2001-06-01

    From the patristic period to the beginning of the seventeenth century curiosity was regarded as an intellectual vice. Curious individuals were considered to be proud and "puffed up," and the objects of their investigations were deemed illicit, dispute engendering, unknowable, or useless. Seventeenth-century projects for the advancement of learning had to distance themselves from curiosity and its dubious fruits or, alternatively, enhance the moral status of the curious sensibility. Francis Bacon's proposals for the instauration of knowledge were an integral part of a process by which curiosity underwent a remarkable transformation from vice to virtue over the course of the seventeenth century. The changing fortunes of this human propensity highlight the morally charged nature of early modern debates over the status of natural philosophy and the particular virtues required of its practitioners. The rehabilitation of curiosity was a crucial element in the objectification of scientific knowledge and led to a gradual shift of focus away from the moral qualities of investigators and the propriety of particular objects of knowledge to specific procedures and methods.

  1. ‘They are called Imperfect men’: Male Infertility and Sexual Health in Early Modern England

    PubMed Central

    Evans, Jennifer

    2016-01-01

    Abstract Scholars of early modern gender and medicine have tended to focus on female infertility. Discussions that have included male reproductive failure have considered sexual ability and impotence, rather than infertility. Nonetheless, fathering children was important to male social standing and the fulfilment of their patriarchal roles. This article will demonstrate that male infertility was not absent from medical literature, but appeared in a variety of settings including tests for infertility, seventeenth-century handbills for treatments, and surgical treatises. It will show that medical and surgical writers accepted that men could be rendered infertile, but still sexually capable, in a variety of ways. Moreover, the article will show that seventeenth-century surgeons expected male readers to be concerned about their reproductive potential and constructed a framework of efficacy based upon their ability to secure on-going fertility. PMID:29731544

  2. Two medieval plague treatises and their afterlife in early modern England.

    PubMed

    Keiser, George R

    2003-07-01

    This study of an adaptation of the popular John of Burgundy plague treatise by Thomas Moulton, a Dominican friar, ca. 1475, and a translation of the so-called Canutus plague treatise by Thomas Paynell, printed 1534, shows how the medieval traditions they represent were carried forward, well into the sixteenth century, and also subjected to change in light of religious, moral, and medical concerns of early modern England. The former had a long life in print, ca. 1530-1580, whereas Paynell's translation exists in one printed version. Moulton's adaptation differs from its original and from the Canutus treatise in putting great emphasis on the idea that onsets of plague were acts of divine retribution for human sinfulness. In this respect, Moulton reshaped the tradition of the medieval plague treatise and anticipated the religious and social construction of plague that would take shape in the first half of the sixteenth century. Its long history in print indicates that Moulton's treatise expressed the spirit of that construction and probably influenced the construction as well. The contrasting histories of the two treatises attest not only to the dramatic change brought about by religious and social forces in the sixteenth century, but to a growing recognition of the value of the printing press for disseminating medical information-in forms that served social and ideological ends.

  3. Breast cancer awareness and barriers to symptomatic presentation among women from different ethnic groups in East London

    PubMed Central

    Forbes, L J L; Atkins, L; Thurnham, A; Layburn, J; Haste, F; Ramirez, A J

    2011-01-01

    Background: During 2001 to 2005, 1-year breast cancer survival was low in ethnically diverse East London. We hypothesised that this was due to low breast cancer awareness and barriers to symptomatic presentation, leading to late stage at diagnosis in women from ethnic minorities. We examined ethnic differences in breast cancer awareness and barriers to symptomatic presentation in East London. Methods: We carried out a population-based survey of 1515 women aged 30+ using the Cancer Research UK Breast Cancer Awareness Measure. We analysed the data using logistic regression adjusting for age group and level of deprivation. Results: South Asian and black women had lower breast cancer awareness than white women. South Asian women, but not black women, reported more emotional barriers to seeking medical help than white women. White women were more likely than non-white women to report worry about wasting the doctor's time as a barrier to symptomatic presentation. Conclusion: Interventions to promote early presentation of breast cancer for South Asian and black women should promote knowledge of symptoms and skills to detect changes, and tackle emotional barriers to symptomatic presentation and for white women tackle the idea that going to the doctor to discuss a breast symptom will waste the doctor's time. PMID:21989188

  4. Bangladeshi women's experiences of infant feeding in the London Borough of Tower Hamlets.

    PubMed

    Rayment, Juliet; McCourt, Christine; Vaughan, Lisa; Christie, Janice; Trenchard-Mabere, Esther

    2016-07-01

    This study examined the main factors that influence Bangladeshi women living in London's decisions to partially breastfeed their children, including the influence of older women within the community. Fifty-seven women of Bangladeshi origin living in the London Borough of Tower Hamlets took part in seven discussion groups between April and June 2013. Five groups were held with women of child-bearing age and two groups with older women in the community. A further eight younger women and three older women took part in one-on-one interviews. Interviews were also carried out with eight local health care workers, including public health specialists, peer support workers, breastfeeding coordinators and a health visitor. The influences on women's infant feeding choices can be understood through a 'socio-ecological model', including public health policy; diverse cultural influences from Bangladesh, London and the Bangladeshi community in London; and the impacts of migration and religious and family beliefs. The women's commitment to breastfeeding was mediated through the complexity of their everyday lives. The tension between what was 'best' and what was 'possible' leads them not only to partially breastfeed but also to sustain partial breastfeeding in a way not seen in other socio-cultural groups in the United Kingdom. © 2015 John Wiley & Sons Ltd.

  5. Space, Emotions and the Everyday: The Affective Ecology of 1980s London.

    PubMed

    Brooke, Stephen

    2017-03-01

    This article explores the relationship between emotions, space and politics in 1980s London, using the Greater London Council, childcare, and racial harassment as particular foci. It brings together political history, the history of emotions, and geography to offer a new way of thinking about political culture, as well as contributing to the history of the 1980s. It is based upon archival sources. © The Author [2016]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  6. Insights into Modern Human Prehistory Using Ancient Genomes.

    PubMed

    Yang, Melinda A; Fu, Qiaomei

    2018-03-01

    The genetic relationship of past modern humans to today's populations and each other was largely unknown until recently, when advances in ancient DNA sequencing allowed for unprecedented analysis of the genomes of these early people. These ancient genomes reveal new insights into human prehistory not always observed studying present-day populations, including greater details on the genetic diversity, population structure, and gene flow that characterized past human populations, particularly in early Eurasia, as well as increased insight on the relationship between archaic and modern humans. Here, we review genetic studies on ∼45000- to 7500-year-old individuals associated with mainly preagricultural cultures found in Eurasia, the Americas, and Africa. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. 77 FR 67566 - Regulated Navigation Area; Thames River Degaussing Range Replacement Operations; New London, CT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ... establishing a regulated navigation area (RNA) on the navigable waters of the Thames River in New London Harbor, New London, CT. The RNA will establish speed and wake restrictions and allow the Coast Guard to prohibit all vessel traffic through the RNA during degaussing range replacement operations, both planned...

  8. History and dating of the publication of the Philadelphia (1822) and London (1823) editions of Edwin James's Account of an expedition from Pittsburgh to the Rocky Mountains

    USGS Publications Warehouse

    Woodman, Neal

    2010-01-01

    The public record of Major Stephen H. Long's 1819–1820 exploration of the American north-west, Account of an expedition from Pittsburgh to the Rocky Mountains, compiled by Edwin James, contains valuable contributions regarding the natural landscapes, native peoples and wildlife of a mostly unexplored region of the American west compiled from the notes of some of America's foremost naturalists, and it includes the first descriptions of 67 new species. The original plan was to publish the Account in Philadelphia and London simultaneously, yet these two editions differ substantially in ways that are relevant to the taxonomic contributions in the work. It is generally assumed that the Philadelphia edition was published in early January 1823 and was available first, but little substantive evidence has been presented to support its priority over the London edition. Review of contemporary correspondence and periodicals indicates the Philadelphia edition was available and for sale on 31 December 1822, whereas the London edition was available in late February 1823. As previously assumed by most sources, the Philadelphia edition has priority of publication and is the authority for most species names. Its correct year of publication, however, is 1822 rather than 1823.

  9. Infant Mortality and Income in 4 World Cities: New York, London, Paris, and Tokyo

    PubMed Central

    Rodwin, Victor G.; Neuberg, Leland G.

    2005-01-01

    Objectives. We investigated the association between average income or deprivation and infant mortality rate across neighborhoods of 4 world cities. Methods. Using a maximum likelihood negative binomial regression model that controls for births, we analyzed data for 1988–1992 and 1993–1997. Results. In Manhattan, for both periods, we found an association (.05% significance level) between income and infant mortality. In Tokyo, for both periods, and in Paris and London for period 1, we found none (5% significance level). For period 2, the association just missed statistical significance for Paris, whereas for London it was significant (5% level). Conclusions. In stark contrast to Tokyo, Paris, and London, the association of income and infant mortality rate was strongly evident in Manhattan. PMID:15623865

  10. 77 FR 54495 - Regulated Navigation Area; Thames River Degaussing Range Replacement Operations; New London, CT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... to establish a regulated navigation area (RNA) on the navigable waters of the Thames River in New London Harbor, New London, CT. The proposed RNA would establish speed and wake restrictions as well as allow the Coast Guard to prohibit all vessel traffic through the RNA during degaussing range replacement...

  11. Redefining Democracy for the Modern State.

    ERIC Educational Resources Information Center

    Rahe, Paul A.

    1992-01-01

    Draws distinctions between classical and modern concepts of democracy. Contrasts Pythagoras' dislike of factions with Madison's support for economic differentiation and religious toleration. Discusses Aristotle's and Noah Webster's ideas on addressing class tensions. Examines early U.S. theorists' suspicions of direct democracy and support for…

  12. Methane Emissions in the London Region: Deciphering Regional Sources with Mobile Measurements

    NASA Astrophysics Data System (ADS)

    Zazzeri, G.; Lowry, D.; Fisher, R. E.; France, J. L.; Lanoisellé, M.; Bjorkegren, A.; Nisbet, E. G.

    2014-12-01

    Methane stable isotope analysis, coupled with mole fraction measurement, has been used to link isotopic signature to methane emissions from the leading methane sources in the London region, such as landfills and gas leaks. A mobile Picarro G2301 CRDS analyser was installed in a vehicle, together with an anemometer and a Hemisphere GPS receiver, to measure atmospheric methane mole fractions and their relative location. When methane plumes were located and intercepted, air samples were collected in Tedlar bags, for δ13C-CH4 isotopic analysis by CF-GC-IRMS (Continous Flow-Gas Chromatography-Isotopic Ratio Mass Spectroscopy). This method provides high precision isotopic values, determining δ13C-CH4 to ±0.05 per mil. The bulk signature of the methane plume into the atmosphere from the whole source area was obtained by Keeling plot analysis, and a δ13C-CH4 signature, with the relative uncertainty, allocated to each methane source investigated. The averaged δ13C-CH4 signature for landfill sites around the London region is - 58 ± 3 ‰, whereas the δ13C-CH4 signature for gas leaks is fairly constant at -36 ± 2 ‰, a value characteristic of North Sea supply. The Picarro G2301 analyser was installed also on the roof of King's College London, located in the centre of the city, and connected to an air inlet located 7 meters above roof height. An auto-sampler was connected to the same air inlet and launched remotely when a high nocturnal build up was expected, allowing up to twenty air bags to be collected for methane isotopic analysis over a 24 hour period. The main source contributing to overnight methane build up in central London is fugitive gas, in agreement with inventories. From the isotopic characterisation of urban methane sources and the source mix in London, the contribution to the urban methane budget and the local distribution of the methane sources given in inventories can be validated.

  13. Contrasting VOC Composition in London, UK and Beijing, China

    NASA Astrophysics Data System (ADS)

    Dunmore, R.; Hopkins, J. R.; Shaw, M.; Squires, F. A.; Lee, J. D.; Lewis, A. C.; Hamilton, J. F.

    2017-12-01

    With an increasing fraction of the world's population now living in megacities, urban air quality in those locations has the potential to be one of the largest controllable factors for public health. Both London and Beijing are classified as megacities, with the latter almost twice as densely populated. The key drivers and trajectory of air pollution are unique to each location; London has substantially reduced PM10 concentrations over the past two decades but continues to have high urban NO2. Beijing has had well-reported high levels of PM, is now in a phase of gradual decline, and has proportionately low NO2. Both locations however, continue to emit a mix of gas phase pollutants with the potential to form photochemical ozone. Whilst the abundance of NOx in each city is relatively straightforward to quantify, the VOC mixtures that are present differ between these two cities and this has consequential impacts on the downwind ozone formation potential. This work reports a comprehensive assessment of VOC speciation, reactivity and abundance in the two cities using a common set of inter-comparable measurement approaches. Hourly observations of VOCs over the range C2 - C13+ were made using two gas chromatography (GC) instruments; a PLOT column based GC for the most volatile fraction (C2-C7) and a comprehensive two-dimensional GC (GCxGC) for VOCs with more than 7 carbons. London has atmospheric VOC concentrations that in mass and reactivity terms are dominated by longer chain VOCs from diesel fuel. The VOC mixture in ambient Beijing air is dominated by short chain VOCs, a mix of both alkenes from incomplete combustion sources and alkanes and aromatics from petrochemical sources. The substantial difference in the fleet proportions of gasoline and diesel powered vehicles between the two cities is clearly reflected in ambient VOCs. In summertime, isoprene was a notable contributor to VOC reactivity in both cities despite both being highly urbanised locations. The absolute

  14. Early Identification System: Year Two. Research Report 80-15.

    ERIC Educational Resources Information Center

    Stennett, R. G.; Earl, L. M.

    During the academic year 1978-79, school teams implemented a newly developed early identification system in all kindergarten and grade one classes in London, Ontario schools. After analysis and revision of the system, the internal consistency and concurrent validity of the process and a test of its short-term predictive validity were investigated.…

  15. VOC emission rates over London and South East England obtained by airborne eddy covariance.

    PubMed

    Vaughan, Adam R; Lee, James D; Shaw, Marvin D; Misztal, Pawel K; Metzger, Stefan; Vieno, Massimo; Davison, Brian; Karl, Thomas G; Carpenter, Lucy J; Lewis, Alastair C; Purvis, Ruth M; Goldstein, Allen H; Hewitt, C Nicholas

    2017-08-24

    Volatile organic compounds (VOCs) originate from a variety of sources, and play an intrinsic role in influencing air quality. Some VOCs, including benzene, are carcinogens and so directly affect human health, while others, such as isoprene, are very reactive in the atmosphere and play an important role in the formation of secondary pollutants such as ozone and particles. Here we report spatially-resolved measurements of the surface-to-atmosphere fluxes of VOCs across London and SE England made in 2013 and 2014. High-frequency 3-D wind velocities and VOC volume mixing ratios (made by proton transfer reaction - mass spectrometry) were obtained from a low-flying aircraft and used to calculate fluxes using the technique of eddy covariance. A footprint model was then used to quantify the flux contribution from the ground surface at spatial resolution of 100 m, averaged to 1 km. Measured fluxes of benzene over Greater London showed positive agreement with the UK's National Atmospheric Emissions Inventory, with the highest fluxes originating from central London. Comparison of MTBE and toluene fluxes suggest that petroleum evaporation is an important emission source of toluene in central London. Outside London, increased isoprene emissions were observed over wooded areas, at rates greater than those predicted by a UK regional application of the European Monitoring and Evaluation Programme model (EMEP4UK). This work demonstrates the applicability of the airborne eddy covariance method to the determination of anthropogenic and biogenic VOC fluxes and the possibility of validating emission inventories through measurements.

  16. The History of Neurosurgery at the National Hospital, Queen Square, London, with Some Personal Recollections from 1948 Onwards: The Early Years.

    PubMed

    Powell, Michael P

    2017-07-01

    The National Hospital, Queen Square, London was founded as a charitable institution in 1860, becoming the first dedicated neuroscience hospital in the world. Sir Victor Horsley, the first neurosurgeon was appointed in 1886, and since that time, Queen Square neurosurgeons have been prominent on the World neurosurgical stage, including Sir Wylie McKissock and Prof Lindsay Symon, inter alia. This article gives the history taken from both published records and personal stories, recorded by a neurosurgeon who has worked at the hospital for thirty five years. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Thinking in early modernity and the separation process between philosophy and psychology.

    PubMed

    Klempe, Sven Hroar

    2015-03-01

    One of the big questions in psychology is when and how psychology disentangled from philosophy. Usually it is referred to the laboratory Wundt established in Leipzig in 1879 as the birth for psychology as an independent science. However this separation process can also be traced in other ways, like by focusing on how the two sciences approach and understand thinking. Although thinking and language were not included in the research in this laboratory, Wundt (1897) regarded thinking as the core of psychology. As a commentary to Papanicolaou (Integr Psychol Behav Sci doi:10.1007/s12124-014-9273-3, 2014), this paper investigates the differences in how psychology and philosophy conceptualized thinking in early Western modernity. Thus one of the findings is that the separation process between the two was more or less initiated by Immanuel Kant. By defining thinking in terms of the pure reason he excluded the psychological understanding of thinking because psychology basically defined thinking in terms of ideas derived from qualia and sensation. Another finding is that psychology itself has not completely realized the differences between the philosophical and the psychological understanding of thinking by having been influenced by Kant's ideal of the pure reason. This may also explain some of the crises psychology went through during the twentieth century.

  18. Vocational training for general practice in inner London. Is there a dearth? And if so what's to be done?

    PubMed Central

    Harris, T.; Silver, T.; Rink, E.; Hilton, S.

    1996-01-01

    OBJECTIVE--To identify the nature and extent of any vocational training deficit within the London initiative zone and investigate the reasons. DESIGN--Collation of statistics and postal questionnaire surveys. SETTING--Thames regions inside and outside the London initiative zone. SUBJECTS--General practice registrars, trainers, principals from non-training practices, and vocational training course organisers. MAIN OUTCOME MEASURES--Trends in numbers of general practice registrars, proportions of trainers, views on current vocational training in inner London. RESULTS--Numbers of general practice registrars fell significantly between 1988 and 1993 within the London initiative zone and in England overall. The number of registrars within the zone fell by more than in the rest of the Thames regions, where the decline was not statistically significant. A lower proportion of principals were approved as trainers within the zone than in the rest of the Thames regions and England overall. In their responses to the survey (88% of inner London registrars responded and 81% of outer Thames registrars) registrars suggested that improving remuneration and personal safety would make training in London more attractive. Trainers and non-trainers (response rates 89% and 66% respectively) also suggested increasing remuneration for trainers together with more protected time for training. CONCLUSIONS--Less vocational training takes place within the London initiative zone than in the rest of the Thames regions and England overall, although there are discrepancies in official statistics. As well as specific recommendations for improving recruitment to vocational training in inner London, measures to tackle inner city deprivation should also remain high on the political agenda. PMID:8555940

  19. Reisebericht London: Interner Workshop: "Knowledge Based Systems in Information Science" (London Travel Report: Internal Workshop: "Knowledge Based Systems in Information Science").

    ERIC Educational Resources Information Center

    Simon, Hans-Reiner

    Written in German, this report summarizes a workshop on teaching and research activities in information science that was held at the City University, London, and attended by faculty and students from the university's Department of Information Science and H.-R. Simon of the GID (Gesellschaft fur Information und Dokumentation), Frankfort am Main,…

  20. Spatially resolved flux measurements of NOx from London suggest significantly higher emissions than predicted by inventories.

    PubMed

    Vaughan, Adam R; Lee, James D; Misztal, Pawel K; Metzger, Stefan; Shaw, Marvin D; Lewis, Alastair C; Purvis, Ruth M; Carslaw, David C; Goldstein, Allen H; Hewitt, C Nicholas; Davison, Brian; Beevers, Sean D; Karl, Thomas G

    2016-07-18

    To date, direct validation of city-wide emissions inventories for air pollutants has been difficult or impossible. However, recent technological innovations now allow direct measurement of pollutant fluxes from cities, for comparison with emissions inventories, which are themselves commonly used for prediction of current and future air quality and to help guide abatement strategies. Fluxes of NOx were measured using the eddy-covariance technique from an aircraft flying at low altitude over London. The highest fluxes were observed over central London, with lower fluxes measured in suburban areas. A footprint model was used to estimate the spatial area from which the measured emissions occurred. This allowed comparison of the flux measurements to the UK's National Atmospheric Emissions Inventory (NAEI) for NOx, with scaling factors used to account for the actual time of day, day of week and month of year of the measurement. The comparison suggests significant underestimation of NOx emissions in London by the NAEI, mainly due to its under-representation of real world road traffic emissions. A comparison was also carried out with an enhanced version of the inventory using real world driving emission factors and road measurement data taken from the London Atmospheric Emissions Inventory (LAEI). The measurement to inventory agreement was substantially improved using the enhanced version, showing the importance of fully accounting for road traffic, which is the dominant NOx emission source in London. In central London there was still an underestimation by the inventory of 30-40% compared with flux measurements, suggesting significant improvements are still required in the NOx emissions inventory.

  1. Seasonal influenza vaccination delivery through community pharmacists in England: evaluation of the London pilot.

    PubMed

    Atkins, Katherine; van Hoek, Albert Jan; Watson, Conall; Baguelin, Marc; Choga, Lethiwe; Patel, Anika; Raj, Thara; Jit, Mark; Griffiths, Ulla

    2016-02-16

    To evaluate the effectiveness and cost of the pan-London pharmacy initiative, a programme that allows administration of seasonal influenza vaccination to eligible patients at pharmacies. We analysed 2013-2015 data on vaccination uptake in pharmacies via the Sonar reporting system, and the total vaccination uptake via 2011-2015 ImmForm general practitioner (GP) reporting system data. We conducted an online survey of London pharmacists who participate in the programme to assess time use data, vaccine choice, investment costs and opinions about the programme. We conducted an online survey of London GPs to assess vaccine choice of vaccine and opinions about the pharmacy vaccine delivery programme. All London boroughs. London-based GPs, and pharmacies that currently offer seasonal flu vaccination. Not applicable. Comparison of annual vaccine uptake in London across risk groups from years before pharmacy vaccination introduction to after pharmacy vaccination introduction. Completeness of vaccine uptake reporting data. Cost to the National Health Service (NHS) of flu vaccine delivery at pharmacies with that at GPs. Cost to pharmacists of flu delivery. Opinions of pharmacists and GPs regarding the flu vaccine pharmacy initiative. No significant change in the uptake of seasonal vaccination in any of the risk groups as a result of the pharmacy initiative. While on average a pharmacy-administered flu vaccine dose costs the NHS up to £2.35 less than a dose administered at a GP, a comparison of the 2 recording systems suggests there is substantial loss of data. Flu vaccine delivery through pharmacies shows potential for improving convenience for vaccine recipients. However, there is no evidence that vaccination uptake increases and the use of 2 separate recording systems leads to time-consuming data entry and missing vaccine record data. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  2. Battersea: Education in a London Parish since 1750

    ERIC Educational Resources Information Center

    Saint, Andrew

    2010-01-01

    This paper examines the development of educational institutions and buildings in one slice of a big city over a long timescale. The city is London and the slice Battersea, an inner suburb of mixed character and volatile fortunes. The narrative explores the shifts and interactions between state and voluntary provision, local community needs and…

  3. Medical pluralism of the Chinese in London: an exploratory study.

    PubMed

    Rochelle, Tina L; Marks, David F

    2010-11-01

    This study was designed to examine the extent of medical pluralism among the Chinese in London. Members of the London Chinese community were recruited through Chinese organizations in London and participated in six focus groups. A total of 48 Chinese men and women aged 24-74 years were asked to talk about their health behaviour and health utilization patterns. Transcripts of the focus group discussions underwent thematic analysis to explore and describe the utilization of traditional Chinese medicine (TCM) and Western medicine (WM) of informants and factors that impacted on utilization. Findings focus on participants' evaluation of TCM and WM as two systems of health provision, how informants used these two health systems, and the reasons associated with use of these two systems. Utilization of TCM and WM varied. Concurrent use of TCM and WM was common. The National Health Service was generally perceived as difficult to use, with concerns over the language barrier, and communicating with and being able to trust health providers. The UK TCM trade was perceived as being aimed at the non-Chinese market and there were issues of trust related to the regulation of UK TCM. Although none of these issues are unique to the Chinese in the UK, previous experience with different approaches to health care, particularly TCM, may make the experience of such barriers more extreme.

  4. Engendering City Politics and Educational Thought: Elite Women and the London Labour Party, 1914-1965

    ERIC Educational Resources Information Center

    Martin, Jane

    2008-01-01

    This article uses biographical approaches to recover the contribution of hitherto neglected figures in the history of education and the political history of the Left in London. Place and location are important since it is important to grasp the uniqueness of the London County Council within the framework of English local government and of the…

  5. Paediatric primary care in Inner London

    PubMed Central

    Jackson, Jane

    1980-01-01

    A week's census was taken of children attending family doctors or hospital accident and emergency departments in an inner city area of London. Most attendances at general hospitals were for cases of trauma while the children's hospital was used mainly by the very young, coming from a wide catchment area. An over-emphasis on hospital-based primary care would not be appropriate in this area and would run counter to the whole philosophy of British medical practice. ImagesFigure 1.Figure 4. PMID:7452588

  6. Theosophy and Revolution: Huntly Carter and the "New Spirit" in Early Soviet Theater

    ERIC Educational Resources Information Center

    Williams, Robert C.

    1977-01-01

    Examines the published works and private correspondence of the English drama critic Huntly Carter and concludes that his religious enthusiasm for early Soviet theatre was more a part of London theosophy in 1914 than the Moscow stage of 1923. (MH)

  7. Education and Modernization in Greece.

    ERIC Educational Resources Information Center

    Kazamias, Andreas M.

    This history of Greek education traces the path of modernization from the emergence of Greece as an independent state in the early 1800's up to the present date. Educational philosophy and content are seen as pawns in the social and political struggles of those years. Detailed coverage of the historical events describes the structure of education…

  8. Connecting Londoners with Their City through Digital Technologies

    ERIC Educational Resources Information Center

    Swift, Frazer

    2013-01-01

    London is one of the most complex, dynamic and diverse cities in the world, with 8 million residents, over 300 languages spoken in its schools, and some 30 million overseas visitors every year. Reaching out to and connecting all these people with the city's heritage while catering to their many interests, motivations and learning needs is a huge…

  9. Facial ontogeny in Neanderthals and modern humans

    PubMed Central

    Bastir, Markus; O'Higgins, Paul; Rosas, Antonio

    2007-01-01

    One hundred and fifty years after the discovery of Neanderthals, it is held that this morphologically and genetically distinct human species does not differ from modern Homo sapiens in its craniofacial ontogenetic trajectory after the early post-natal period. This is striking given the evident morphological differences between these species, since it implies that all of the major differences are established by the early post-natal period and carried into adulthood through identical trajectories, despite the extent to which mechanical and spatial factors are thought to influence craniofacial ontogeny. Here, we present statistical and morphological analyses demonstrating that the spatio-temporal processes responsible for craniofacial ontogenetic transformations differ. The findings emphasize that pre-natal as well as post-natal ontogeny are both important in establishing the cranial morphological differences between adult Neanderthals and modern humans. PMID:17311777

  10. Changing incidence and management of penetrating neck injuries in the South East London trauma centre.

    PubMed

    Harris, R; Olding, C; Lacey, C; Bentley, R; Schulte, K M; Lewis, D; Kandasamy, N; Oakley, R

    2012-05-01

    A total of 17 cases of penetrating neck injury were managed by the otolaryngology team at King's College Hospital over a 3-year period in the 1980s. In April 2010 King's College Hospital became the major trauma centre for South East London. This prospective cohort study compares the incidence, changing demographic features and treatment outcomes of penetrating neck trauma in South East London over the previous 23 years. Data were collected over a 12-month period (April 2010 to March 2011) and a selective management protocol was introduced to standardise initial investigations and further treatment. The past 23 years have seen a 550% increase in the incidence of penetrating neck injuries in South East London, with a marked increase in gun crime. Only 38% of cases underwent negative neck exploration in 2011 compared with 65% in 1987. Selective conservative management based on the absence of haemodynamic instability or radiological findings reduces length of hospital stay, lightens surgical workload and cuts costs without affecting morbidity or mortality. The increased incidence of penetrating neck injury is a reflection of more interpersonal violence rather than a consequence of the larger South East London trauma centre catchment area. Tackling this problem requires focus on wider issues of community prevention. Sharing of data between the four London trauma centres and the police is needed to help prevent interpersonal violence and develop a universal treatment algorithm for other institutions to follow.

  11. Modern Microbial Ecosystems are a Key to Understanding Our Biosphere's Early Evolution and its Contributions To The Atmosphere and Rock Record

    NASA Technical Reports Server (NTRS)

    DesMarais, David J.; DeVincenzi, Donald L. (Technical Monitor)

    2000-01-01

    The survival of our early biosphere depended upon efficient coordination anion- diverse microbial populations. Microbial mats exhibit a 3.46-billion-year fossil record, thus they are the oldest known ecosystems. Photosynthetic microbial mats were key because, today, sunlight powers more than 99 percent of global primary productivity. Thus photosynthetic ecosystems have affected the atmosphere profoundly and have created the most pervasive, easily-detected fossils. Photosynthetic biospheres elsewhere will be most detectible via telescopes or spacecraft. As a part of the Astrobiology Institute, our Ames Microbial Ecosystems group examines the roles played by ecological processes in the early evolution of our biosphere, as recorded in geologic fossils and in the macromolecules of living cells: (1) We are defining the microbial mat microenvironment, which was an important milieu for early evolution. (2) We are comparing mats in contrasting environments to discern strategies of adaptation and diversification, traits that were key for long-term survival. (3) We have selected sites that mimic key environmental attributes of early Earth and thereby focus upon evolutionary adaptations to long-term changes in the global environment. (4) Our studies of gas exchange contribute to better estimates of biogenic gases in Earth's early atmosphere. This group therefore directly addresses the question: How have the Earth and its biosphere influenced each other over time Our studies strengthen the systematics for interpreting the microbial fossil record and thereby enhance astrobiological studies of martian samples. Our models of biogenic gas emissions will enhance models of atmospheres that might be detected on inhabited extrasolar planets. This work therefore also addresses the question: How can other biospheres be recogniZed" Our choice of field sites helps us explore Earth's evolving early environment. For example, modern mats that occupy thermal springs and certain freshwater

  12. Using GIS to Understand and Prioritise Worker Movements during the 2012 London Olympics

    NASA Astrophysics Data System (ADS)

    McGuinness, I. M.

    2013-05-01

    The performance of the transport network and the associated movement of people was one of the most critical elements to London's successful delivery of the 2012 Olympic Games. During the planning stages Transport for London asked the London Borough of Newham to mitigate the impact of the authority's 13 500 employees on transport infrastructure close to the Olympic Park. To achieve this, the authority needed to understand the geographic distribution of its workforce and the demand it placed on roads and local transport hubs. The authority's Geospatial Team led the research based on four cross-referenced data sources, and spatial analysis was used to determine priorities for special absence arrangements and a commissioned coach service. The research was used to support a targeted information campaign but also presented considerations on large-scale data collection, the use of Human Resources data, and the degree to which the movement of people can be measured and managed.

  13. Tracer concentration profiles measured in central London as part of the REPARTEE campaign

    NASA Astrophysics Data System (ADS)

    Martin, D.; Petersson, K. F.; White, I. R.; Henshaw, S. J.; Nickless, G.; Lovelock, A.; Barlow, J. F.; Dunbar, T.; Wood, C. R.; Shallcross, D. E.

    2009-11-01

    There have been relatively few tracer experiments carried out that have looked at vertical plume spread in urban areas. In this paper we present results from cyclic perfluorocarbon tracer experiments carried out in 2006 and 2007 in central London centred on the BT Tower as part of the REPARTEE (Regent's Park and Tower Environmental Experiment) campaign. The height of the tower gives a unique opportunity to study dispersion over a large vertical gradient. These gradients are then compared with classical Gaussian profiles of the relevant stability classes over a range of distances as well as interpretation of data with reference to both anemometry and LIDAR measurements made. Data are then compared with an operational model and contrasted with data taken in central London as part of the DAPPLE campaign looking at dosage compared with non-dimensionalised distance from source. Such analysis illustrates the feasibility of the use of these empirical correlations over these prescribed distances in central London.

  14. Health effects of the London bicycle sharing system: health impact modelling study

    PubMed Central

    Tainio, Marko; Cheshire, James; O’Brien, Oliver; Goodman, Anna

    2014-01-01

    Objective To model the impacts of the bicycle sharing system in London on the health of its users. Design Health impact modelling and evaluation, using a stochastic simulation model. Setting Central and inner London, England. Data sources Total population operational registration and usage data for the London cycle hire scheme (collected April 2011-March 2012), surveys of cycle hire users (collected 2011), and London data on travel, physical activity, road traffic collisions, and particulate air pollution (PM2.5, (collected 2005-12). Participants 578 607 users of the London cycle hire scheme, aged 14 years and over, with an estimated 78% of travel time accounted for by users younger than 45 years. Main outcome measures Change in lifelong disability adjusted life years (DALYs) based on one year impacts on incidence of disease and injury, modelled through medium term changes in physical activity, road traffic injuries, and exposure to air pollution. Results Over the year examined the users made 7.4 million cycle hire trips (estimated 71% of cycling time by men). These trips would mostly otherwise have been made on foot (31%) or by public transport (47%). To date there has been a trend towards fewer fatalities and injuries than expected on cycle hire bicycles. Using these observed injury rates, the population benefits from the cycle hire scheme substantially outweighed harms (net change −72 DALYs (95% credible interval −110 to −43) among men using cycle hire per accounting year; −15 (−42 to −6) among women; note that negative DALYs represent a health benefit). When we modelled cycle hire injury rates as being equal to background rates for all cycling in central London, these benefits were smaller and there was no evidence of a benefit among women (change −49 DALYs (−88 to −17) among men; −1 DALY (−27 to 12) among women). This sex difference largely reflected higher road collision fatality rates for female cyclists. At older ages the modelled

  15. Developing an Integrated Institutional Repository at Imperial College London

    ERIC Educational Resources Information Center

    Afshari, Fereshteh; Jones, Richard

    2007-01-01

    Purpose: This paper aims to demonstrate how a highly integrated approach to repository development and deployment can be beneficial in producing a successful archive. Design/methodology/approach: Imperial College London undertook a significant specifications process to gather and formalise requirements for its repository system. This was done…

  16. Provision of out-of-hours interventional radiology services in the London strategic health authority.

    PubMed

    Illing, R O; Clark, C L Ingham; Allum, C

    2010-04-01

    To review the provision of out-of-hours interventional radiology (IR) services in the London Strategic Health Authority (SHA). All 29 acute hospitals in the London SHA were contacted between November 2008 and January 2009. A questionnaire based on the Royal College of Radiologists (RCR) guidelines assessed the provision of out-of-hours IR services. An "ad-hoc" service was defined as on-call provision where not all the radiologists could perform intervention: If IR was required out of hours, an interventionalist came in when off-duty or the patient was transferred. Seventeen out of the 29 (59%) hospitals provided ad-hoc out-of-hours services, eight (28%) provided a 24-hour rota, and four (14%) provide no out-of-hours cover. No ad-hoc service had formal transfer arrangements to a centre providing a 24h service. Only two hospitals providing a 24h service had six radiologists on the rota. Strategic planning for out-of-hours IR across London is recommended. This is likely to be welcomed by the hospitals involved, allowing informal arrangements to be formalized, and collaboration to provide comprehensive regional networks, provided appropriate funding is made available. A national audit is recommended; it is unlikely these findings are unique to London.

  17. Parasuicide in central London 1984-1988.

    PubMed Central

    Fuller, G N; Rea, A J; Payne, J F; Lant, A F

    1989-01-01

    Experience of a central London unit dedicated to the care of patients following parasuicide between 1984 and 1988 is reviewed. There were 1160 admissions, which accounted for 11% of all acute adult medical admissions. The female to male ratio was 1.3, with a peak rate for females below 25 years and for males between 20 and 35. Unemployment was found to be a risk factor for parasuicide in men. Benzodiazepines were the most frequently used drug in parasuicide (35%), followed by paracetamol (13%) and aspirin (9%). PMID:2574238

  18. Seasonality of Formic Acid (HCOOH) in London during the ClearfLo Campaign: Seasonality of Formic Acid in London

    DOE PAGES

    Bannan, Thomas J.; Murray Booth, A.; Le Breton, Michael; ...

    2017-11-09

    Following measurements in the winter of 2012, formic acid (HCOOH) and nitric acid (HNO 3) were measured using a chemical ionization mass spectrometer (CIMS) during the Summer Clean Air for London (ClearfLo) campaign in London, 2012. Consequently, the seasonal dependence of formic acid sources could be better understood. A mean formic acid concentration of 1.3 ppb and a maximum of 12.7 ppb was measured which is significantly greater than that measured during the winter campaign (0.63 ppb and 6.7 ppb, respectively). Daily calibrations of formic acid during the summer campaign gave sensitivities of 1.2 ion counts s -1 parts permore » trillion (ppt) by volume -1 and a limit of detection of 34 ppt. During the summer campaign, there was no correlation between formic acid and anthropogenic emissions such as NO x and CO or peaks associated with the rush hour as was identified in the winter. Rather, peaks in formic acid were observed that correlated with solar irradiance. Analysis using a photochemical trajectory model has been conducted to determine the source of this formic acid. The contribution of formic acid formation through ozonolysis of alkenes is important but the secondary production from biogenic VOCs could be the most dominant source of formic acid at this measurement site during the summer.« less

  19. Seasonality of Formic Acid (HCOOH) in London during the ClearfLo Campaign: Seasonality of Formic Acid in London

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bannan, Thomas J.; Murray Booth, A.; Le Breton, Michael

    Following measurements in the winter of 2012, formic acid (HCOOH) and nitric acid (HNO 3) were measured using a chemical ionization mass spectrometer (CIMS) during the Summer Clean Air for London (ClearfLo) campaign in London, 2012. Consequently, the seasonal dependence of formic acid sources could be better understood. A mean formic acid concentration of 1.3 ppb and a maximum of 12.7 ppb was measured which is significantly greater than that measured during the winter campaign (0.63 ppb and 6.7 ppb, respectively). Daily calibrations of formic acid during the summer campaign gave sensitivities of 1.2 ion counts s -1 parts permore » trillion (ppt) by volume -1 and a limit of detection of 34 ppt. During the summer campaign, there was no correlation between formic acid and anthropogenic emissions such as NO x and CO or peaks associated with the rush hour as was identified in the winter. Rather, peaks in formic acid were observed that correlated with solar irradiance. Analysis using a photochemical trajectory model has been conducted to determine the source of this formic acid. The contribution of formic acid formation through ozonolysis of alkenes is important but the secondary production from biogenic VOCs could be the most dominant source of formic acid at this measurement site during the summer.« less

  20. Socioeconomic Status and Functional Brain Development--Associations in Early Infancy

    ERIC Educational Resources Information Center

    Tomalski, Przemyslaw; Moore, Derek G.; Ribeiro, Helena; Axelsson, Emma L.; Murphy, Elizabeth; Karmiloff-Smith, Annette; Johnson, Mark H.; Kushnerenko, Elena

    2013-01-01

    Socioeconomic status (SES) impacts on both structural and functional brain development in childhood, but how early its effects can be demonstrated is unknown. In this study we measured resting baseline EEG activity in the gamma frequency range in awake 6-9-month-olds from areas of East London with high socioeconomic deprivation. Between-subject…

  1. Intergenerational Learning between Children and Grandparents in East London

    ERIC Educational Resources Information Center

    Kenner, Charmian; Ruby, Mahera; Jessel, John; Gregory, Eve; Arju, Tahera

    2007-01-01

    This study investigates the learning exchange between three- to six-year-old children and their grandparents, in Sylheti/Bengali-speaking families of Bangladeshi origin and monolingual English-speaking families living in east London. The following concepts from sociocultural theory are applied to this new area of intergenerational learning:…

  2. Place and provision: mapping mental health advocacy services in London.

    PubMed

    Foley, Ronan; Platzer, Hazel

    2007-02-01

    The National Health Service (NHS) Executive for London carried out an investigation in 2002 as part of their wider mental health strategy to establish whether existing mental health advocacy provision in the city was meeting need. The project took a two-part approach, with an emphasis on, (a) mapping the provision of advocacy services and, (b) cartographic mapping of service location and catchments. Data were collected through a detailed questionnaire with service providers in collaboration with the Greater London Mental Health Advocacy Network (GLMHAN) and additional health and government sources. The service mapping identified some key statistics on funding, caseloads and models of service provision with an additional emphasis on coverage, capacity, and funding stability. The questionnaire was augmented by interviews and focus groups with commissioners, service providers and service users and identified differing perspectives and problems, which informed the different perspectives of each of these groups. The cartographic mapping exercise demonstrated a spatially-even provision of mental health advocacy services across the city with each borough being served by at least one local service as well as by London wide specialist schemes. However, at local level, no one borough had the full range of specialist provision to match local demographic need. Ultimately the research assisted the Advisory Group in providing commissioning agencies with clear information on the current status of city-wide mental health advocacy services, and on gaps in existing advocacy provision alongside previously unconsidered geographical and service dimensions of that provision.

  3. The Interfaces Between Historical, Paleo-, and Modern Climatology

    NASA Astrophysics Data System (ADS)

    Mock, C. J.

    2011-12-01

    Historical climatology, commonly defined as the study of reconstructing past climates from documentary and early instrumental data, has routinely utilized data within the last several hundred years down to sub-daily temporal resolution prior to the advent of "modern" instrumental records beginning in the late 19th and 20th centuries. Historical climate reconstruction methods generally share similar aspects conducted in both paleoclimate reconstruction and modern climatology, given the need to quantify, calibrate, and conduct careful data quality assessments. Although some studies have integrated historical climatic studies with other high resolution paleoclimatic proxies, very few efforts have integrated historical data with modern "systematic" climate networks to further examine spatial and temporal patterns of climate variability. This presentation describes historical climate examples of how such data can be integrated within modern climate timescales, including examples of documentary data on tropical cyclones from the Western Pacific and Atlantic Basins, colonial records from Belize and Constantinople, ship logbooks in the Western Arctic, plantation diaries from the American Southeast, and newspaper data from the Fiji Islands and Bermuda. Some results include a unique wet period in Belize and active tropical cyclone periods in the Western and South Pacific in the early 20th century - both are not reflected in conventional modern climate datasets. Documentary data examples demonstrate high feasibility in further understanding extreme weather events at daily timeframes such as false spring/killing frost episodes and hydrological extremes in southeastern North America. Recent unique efforts also involve community participation, secondary education, and web- based volunteer efforts to digitize and archive historical weather and climate information.

  4. Cerebral localization in the nineteenth century--the birth of a science and its modern consequences.

    PubMed

    Steinberg, David A

    2009-07-01

    Although many individuals contributed to the development of the science of cerebral localization, its conceptual framework is the work of a single man--John Hughlings Jackson (1835-1911), a Victorian physician practicing in London. Hughlings Jackson's formulation of a neurological science consisted of an axiomatic basis, an experimental methodology, and a clinical neurophysiology. His axiom--that the brain is an exclusively sensorimotor machine--separated neurology from psychiatry and established a rigorous and sophisticated structure for the brain and mind. Hughlings Jackson's experimental method utilized the focal lesion as a probe of brain function and created an evolutionary structure of somatotopic representation to explain clinical neurophysiology. His scientific theory of cerebral localization can be described as a weighted ordinal representation. Hughlings Jackson's theory of weighted ordinal representation forms the scientific basis for modern neurology. Though this science is utilized daily by every neurologist and forms the basis of neuroscience, the consequences of Hughlings Jackson's ideas are still not generally appreciated. For example, they imply the intrinsic inconsistency of some modern fields of neuroscience and neurology. Thus, "cognitive imaging" and the "neurology of art"--two topics of modern interest--are fundamentally oxymoronic according to the science of cerebral localization. Neuroscientists, therefore, still have much to learn from John Hughlings Jackson.

  5. Are the birch trees in Southern England a source of Betula pollen for North London?

    PubMed

    Skjøth, C A; Smith, M; Brandt, J; Emberlin, J

    2009-01-01

    Birch pollen is highly allergenic. Knowledge of daily variations, atmospheric transport and source areas of birch pollen is important for exposure studies and for warnings to the public, especially for large cities such as London. Our results show that broad-leaved forests with high birch tree densities are located to the south and west of London. Bi-hourly Betula pollen concentrations for all the days included in the study, and for all available days with high birch pollen counts (daily average birch pollen counts>80 grains/m3), show that, on average, there is a peak between 1400 hours and 1600 hours. Back-trajectory analysis showed that, on days with high birch pollen counts (n=60), 80% of air masses arriving at the time of peak diurnal birch pollen count approached North London from the south in a 180 degree arc from due east to due west. Detailed investigations of three Betula pollen episodes, with distinctly different diurnal patterns compared to the mean daily cycle, were used to illustrate how night-time maxima (2200-0400 hours) in Betula pollen counts could be the result of transport from distant sources or long transport times caused by slow moving air masses. We conclude that the Betula pollen recorded in North London could originate from sources found to the west and south of the city and not just trees within London itself. Possible sources outside the city include Continental Europe and the Betula trees within the broad-leaved forests of Southern England.

  6. Autistic Disorder in Nineteenth-Century London. Three Case Reports

    ERIC Educational Resources Information Center

    Waltz, Mitzi; Shattock, Paul

    2004-01-01

    This article examines the existence, description, perception, treatment, and outcome of symptoms consistent with autistic disorder in nineteenth-century London, England, based on case histories from the notes of Dr William Howship Dickinson at Great Ormond Street Hospital for Children. Three cases meeting the DSM-IV criteria for autistic disorder…

  7. An analysis of population and social change in London wards in the 1980s.

    PubMed

    Congdon, P

    1989-01-01

    "This paper discusses the estimation and projection of small area populations in London, [England] and considers trends in intercensal social and demographic indices which can be calculated using these estimates. Information available annually on vital statistics and electorates is combined with detailed data from the Census Small Area Statistics to derive demographic component based population estimates for London's electoral wards over five year periods. The availability of age disaggregated population estimates permits derivation of small area social indicators for intercensal years, for example, of unemployment and mortality. Trends in spatial inequality of such indicators during the 1980s are analysed and point to continuing wide differentials. A typology of population and social indicators gives an indication of the small area distribution of the recent population turnaround in inner London, and of its association with other social processes such as gentrification and ethnic concentration." excerpt

  8. Graded Interface Models for more accurate Determination of van der Waals-London Dispersion Interactions across Grain Boundaries

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    van Benthem, Klaus; Tan, Guolong; French, Roger H

    2006-01-01

    Attractive van der Waals V London dispersion interactions between two half crystals arise from local physical property gradients within the interface layer separating the crystals. Hamaker coefficients and London dispersion energies were quantitatively determined for 5 and near- 13 grain boundaries in SrTiO3 by analysis of spatially resolved valence electron energy-loss spectroscopy (VEELS) data. From the experimental data, local complex dielectric functions were determined, from which optical properties can be locally analysed. Both local electronic structures and optical properties revealed gradients within the grain boundary cores of both investigated interfaces. The obtained results show that even in the presence ofmore » atomically structured grain boundary cores with widths of less than 1 nm, optical properties have to be represented with gradual changes across the grain boundary structures to quantitatively reproduce accurate van der Waals V London dispersion interactions. London dispersion energies of the order of 10% of the apparent interface energies of SrTiO3 were observed, demonstrating their significance in the grain boundary formation process. The application of different models to represent optical property gradients shows that long-range van der Waals V London dispersion interactions scale significantly with local, i.e atomic length scale property variations.« less

  9. Molecular Self-Assembly Driven by London Dispersion Forces

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Guo; Cooper, Valentino R; Cho, Jun-Hyung

    2011-01-01

    The nature and strength of intermolecular interactions are crucial to a variety of kinetic and dynamic processes at surfaces. Whereas strong chemisorption bonds are known to facilitate molecular binding, the importance of the weaker yet ubiquitous van der Waals (vdW) interactions remains elusive in most cases. Here we use first-principles calculations combined with kinetic Monte Carlo simulations to unambiguously demonstrate the vital role that vdW interactions play in molecular self-assembly, using styrene nanowire growth on silicon as a prototypical example. We find that, only when the London dispersion forces are included, accounting for the attractive parts of vdW interactions, canmore » the effective intermolecular interaction be reversed from being repulsive to attractive. Such attractive interactions, in turn, ensure the preferred growth of long wires under physically realistic conditions as observed experimentally. We further propose a cooperative scheme, invoking the application of an electric field and the selective creation of Si dangling bonds, to drastically improve the ordered arrangement of the molecular structures. The present study represents a significant step forward in the fundamental understanding and precise control of molecular self-assembly guided by London dispersion forces.« less

  10. Central and East European migrant men who have sex with men in London: a comparison of recruitment methods.

    PubMed

    Evans, Alison R; Hart, Graham J; Mole, Richard; Mercer, Catherine H; Parutis, Violetta; Gerry, Christopher J; Imrie, John; Burns, Fiona M

    2011-05-17

    Following the expansion of the European Union, there has been a large influx of Central and East European (CEE) migrants to the UK. CEE men who have sex with men (MSM) represent a small minority within this population that are none-the-less important to capture in sexual health research among the CEE migrant community. This paper examines the feasibility of recruiting CEE MSM for a survey of sexual behaviour in London using respondent driven sampling (RDS), via gay websites and in GUM clinics. We sought CEE MSM to start RDS chain referral among GUM clinic attendees, our personal contacts and at gay events and venues in central London. We recruited CEE MSM (n = 485) via two popular websites for gay men in Britain (March-May 2009) and at two central London GUM clinics (n = 51) (July 2008-March 2009). We found seventeen men who knew other CEE MSM in London and agreed to recruit contacts into the study. These men recruited only three men into the study, none of whom recruited any further respondents, and RDS was abandoned after 7 months (July 2008-January 2009). Half of the men that we approached to participate in RDS did not know any other CEE MSM in London. Men who agreed to recruit contacts for RDS were rather more likely to have been in the UK for more than one year (94.1% vs 70.0%, p = 0.052). Men recruited through gay websites and from GUM clinics were similar. The Internet was the most successful method for collecting data on sexual risk behaviour among CEE MSM in London. CEE MSM in London were not well networked. RDS may also have failed because they did not fully understand the procedure and/or the financial incentive was not sufficient motivation to take part.

  11. A Community Approach to Youth Work in East London.

    ERIC Educational Resources Information Center

    Cox, Derek M.

    Instituted as part of "Avenues Unlimited" (The Tower Hamlets Youth Project), a community development approach to youth services was attempted in the cosmopolitan inner city slum district of Spitalfields, East London. Efforts began in 1966 with a clean up campaign, a neighborhood club for parents and youth, and other activities by the…

  12. Early Childhood Education.

    ERIC Educational Resources Information Center

    Elkind, David

    In five sections, this paper explores dimensions of early childhood education: schooling generally construed as nonparental instruction in knowledge, values, and skills. Section 1 looks at some of the factors which have contributed to the rapid growth of early childhood education in modern times. Section 2 briefly highlights the contributions of…

  13. Active euthanasia in pre-modern society, 1500-1800: learned debates and popular practices.

    PubMed

    Stolberg, Michael

    2007-08-01

    Historians of medical ethics have found that active euthanasia, in the sense of intentionally hastening the death of terminally-ill patients, was considered unacceptable in the Christian West before the 1870s. This paper presents a range of early modern texts on the issue which reflect a learned awareness of practices designed to shorten the lives of dying patients which were widely accepted among the lay public. Depriving the dying abruptly of their head-rest or placing them flat on the cold floor may strike us as merely symbolic today, but early moderns associated such measures with very concrete and immediate effects. In this sense, the intentional hastening of death in agonising patients had an accepted place in pre-modern popular culture. These practices must, however, be put into their proper context. Death was perceived more as a transition to the after-life and contemporary notions of dying could make even outright suffocation appear as an act of compassion which merely helped the soul depart from the body at the divinely ordained hour of death. The paper concludes with a brief comparison of early modern arguments with those of today.

  14. Escherichia Coli--Key to Modern Genetics.

    ERIC Educational Resources Information Center

    Bregegere, Francois

    1982-01-01

    Mid-nineteenth century work by Mendel on plant hybrids and by Pasteur on fermentation gave birth by way of bacterial genetics to modern-day molecular biology. The bacterium Escherichia Coli has occupied a key position in genetic studies leading from early gene identification with DNA to current genetic engineering using recombinant DNA technology.…

  15. Making Bengali Brick Lane: claiming and contesting space in East London.

    PubMed

    Alexander, Claire

    2011-06-01

    Based on a recent empirical project on 'the Bengal diaspora', the paper explores the construction and contestation of meanings around the iconic East London street, Brick Lane. Taking the 2006 protests around the film Brick Lane as its starting point, the paper draws on original interviews conducted in 2008 with a range of Bengali community representatives, to examine the narratives of space, community and belonging that emerge around the idea of Brick Lane as the 'cultural heartland' of the British Bangladeshi community. By exploring the representation, production and contestation of 'social space' through everyday practices, the paper engages with and contests the representation of minority ethnic 'communities' in the context of contemporary multicultural London and examines the process of 'claiming' and 'making' space in East London. In so doing, the paper contributes to a critical tradition that challenges essentialising and pathologizing accounts of ethnic communities and racialized spaces, or that places them outside of broader social and historical processes - redolent, for example, in contemporary discussions about 'parallel lives' or 'the clash of civilizations'. By contrast, this paper views social space as made through movement and narration, with a particular emphasis on the social agency of local Bengali inhabitants and the multiple meanings that emerge from within this 'imagined community'. However, rather than simply stressing the unfinished and processual nature of spatial meanings, the paper insists on the historical, embodied and affective dimensions of such meaning making, and a reckoning with the broader social and political landscape within which such meanings take shape. The focus on Brick Lane provides an empirically rich, geographically and historically located lens through which to explore the complex role of ethnicity as a marker of social space and of spatial practices of resistance and identity. By exploring Bengali Brick Lane through

  16. Obesity, physical activity and traumatic dental injuries in adolescents from East London.

    PubMed

    Aswathikutty, Aswathikutty; Marcenes, Wagner; Stansfeld, Stephen A; Bernabé, Eduardo

    2017-04-01

    Evidence on the interplay between obesity, physical activity and traumatic dental injuries (TDIs) is still inconclusive and heavily based on cross-sectional studies. The aim of this study was to explore the interrelationship of obesity and physical activity at age 11-12 years with TDI at age 15-16-years among schoolchildren from East London. Data were analysed regarding 598 adolescents who participated in phases I and III of the Research with East London Adolescents Community Health Survey (RELACHS), a longitudinal, school-based study of adolescents in East London. Participants reported their level of physical activity and their height and weight were measured to estimate body mass index Z-scores (according to the UK growth reference) when they were 11-12 years old. Oral clinical examinations were conducted to assess TDI, overjet and lip coverage when participants were 15-16 years old. The associations of obesity and physical activity with TDI were evaluated in crude and adjusted models using binary logistic regression. Overall, 22.6% of adolescents were obese and 7.2% exercised for 7 h or more a week at baseline, while 18.1% of adolescents had experienced TDI by age 15-16 years. Physical activity (7+ hours per week) was significantly associated with TDI (odds ratio: 2.19; 95% confidence interval: 1.08-4.43) in the crude model. However, no significant associations were found between obesity and TDI (1.18; 95% CI: 0.72-1.93) or physical activity and TDI (1.96; 95% CI: 0.94-4.07) in adjusted models. This study found no evidence of any associations of obesity and physical activity with TDI among adolescents from East London. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. Remembering Childhood: Do Our Memories and Experiences Influence Our Understanding of Early Childhood and Our Practice with Young Children?

    ERIC Educational Resources Information Center

    Horsley, Karen; Penn, Helen

    2014-01-01

    Students on the Early Childhood Studies degree programme at the University of East London were asked to reflect on their childhood memories and how these have shaped their understandings of early childhood and practices with young children. Students' rich and varied accounts reflect the diversity of largely non-traditional students from countries…

  18. Thinking with the saint: the miracle of Saint Januarius of Naples and science in early modern Europe.

    PubMed

    de Ceglia, Francesco Paolo

    2014-01-01

    The aim of this paper is to reconstruct the way in which early modem science questioned and indirectly influenced (while being in its turn influenced by) the conceptualization of the liquefaction of the blood of Saint Januarius, a phenomenon that has been taking place at regular intervals in Naples since the late Middle Ages. In the seventeenth century, a debate arose that divided Europe between supporters of a theory of divine intervention and believers in the occult properties of the blood. These two theoretical options reflected two different perspectives on the relationship between the natural and the supernatural. While in the seventeenth century, the emphasis was placed on the predictable periodicity of the miraculous event of liquefaction as a manifestation of God in his role as a divine regulator, in the eighteenth century the event came to be described as capricious and unpredictable, in an attempt to differentiate miracles from the workings of nature, which were deemed to be normative. The miracle of the blood of Saint Januarius thus provides a window through which we can catch a glimpse of how the natural order was perceived in early modern Europe at a time when the Continent was culturally fragmented into north and south, Protestantism and Catholicism, learned and ignorant.

  19. In London, a Working-Class University Wrestles with Change

    ERIC Educational Resources Information Center

    Labi, Aisha

    2012-01-01

    Patrick McGhee, vice chancellor of the University of East London, has a lot in common with many of the 28,000 students at the large urban institution he leads. He was the first in his family to attend university. And he dislikes much about the government's higher-education reform efforts, which he has deemed "misguided, premature, unproven…

  20. Sickle-cell haemoglobin C disease in London

    PubMed Central

    Black, A. J.; Condon, P. I.; Gompels, B. M.; Green, R. L.; Huntsman, R. G.; Jenkins, G. C.

    1972-01-01

    The manifestations of the sickling disorders are becoming increasingly familiar to clinicians in Great Britain. One of these disorders, sickle-cell haemoglobin disease, has hitherto received little attention, being regarded as a relatively mild condition. This paper describes some of the distinctive clinical features of the disease as seen in a series of nine cases which have recently presented in London, two of which were fatal. The special hazards of the condition in relation to pregnancy, air travel, and general anaesthesia are discussed. Images PMID:5015374

  1. Individualizing Japan: searching for its origin in first modernity.

    PubMed

    Suzuki, Munenori; Ito, Midori; Ishida, Mitsunori; Nihei, Norihiro; Maruyama, Masao

    2010-09-01

    Since the mid-1990s Japanese society has entered a period of major change. The previous patterns of social order and social integration have collapsed, and it has become increasingly difficult to envision a stable life course for oneself. The 'secure' foundation has been weakening and anxiety has spread at an accelerated pace. Japan could enter the age of second modernity, or reflexive modernization. In Japan's first modernity, the mechanism responsible for risk management, an integrated society, and stabilized social order, was, first, private corporations that guaranteed long-term stability for employees and their families (company-centrism) and, second, land development rapidly implemented under the guidance of bureaucrats (developmentalism). From the 1990s, these systems were fundamentally destroyed by globalization and neoliberal policies. Private corporations limited the groups that could benefit from the seniority wage system, undermining in-house welfare benefits. The government abandoned its role of improving the industrial and economic conditions of surrounding areas through offering public works projects. After these risk-stabilizing mechanisms were gone, two problems became conspicuous - poverty among young workers in urban areas and the collapse of the local community in marginal areas. As the seniority wage system and lifetime employment were substitutes for the public social security system, public measures to deal with poverty remain inadequate. Now, the individualization of the family has advanced somewhat under compulsion as the rate of unmarried people and the divorce rate have climbed. The Japanese have a tendency to seek 'self-realization'; at the same time, they also want 'secure employment'. Thus, they are torn between individualization and the desire for security. What is now necessary is a more stable system that will ensure them adequate material and spiritual 'elbowroom' to allow them to make their own choices. © London School of

  2. Gender Politics and Privatization in the London Borough of Camden.

    ERIC Educational Resources Information Center

    Brush, Lisa D.

    1986-01-01

    This article examines the differential impact of the privatization of social services on women in the London borough of Camden. Concludes that women will suffer greater decline than men in employment, wages, and status as a result of the privatization taking place in Great Britain. (JDH)

  3. In vitro transfer of multiple resistance observed in vivo during a Salmonella london epidemic.

    PubMed

    Lantos, J; Marjai, E

    1980-01-01

    Between 1976 and 1978, waves of Salmonella london infections conveyed by raw meat and meat products were observed. The strains isolated during the epidemic were first susceptible then developed multiple antibiotic resistance. The identical antibiotic resistance patterns of the strain and their more frequent occurrence in hospital environments indicated plasmid-mediated resistance. R-plasmid transfer, minimum inhibition concentration and resistance elimination were studied in representative strains. The resistant S. london strain and transconjugants of Escherichia coli rendered resistant were compared. The results proved that multiple resistance was plasmid-mediated.

  4. [Strategies of medical self-authorization in early modern medicine: the example of Volcher Coiter (1534-1576)].

    PubMed

    Gross, Dominik; Steinmetzer, Jan

    2005-01-01

    Based on the example of Volcher Coiter--a town physician at Nuremberg and one of the leading anatomists in early modern medicine--, this essay points out that the authoritative status of contemporary physicians mainly was predicated on an interplay of self-fashioning and outside perception. It provides ample evidence that Coiter made use of several characteristic rhetorical and discourse-related strategies of self-authorisation such as the participation in social networks, a highly convincing technique of self-fashioning by emphasizing particular erudition, the presentation of academic medicine as a science authorised by god and the concurrent devaluation of non-academic healers. Furthermore, graphic and visual strategies of self-authorisation could be ascertained: Coiter took care for a premium typography of his books. He also used his talent as a graphic artist in his books to visualise his medical concepts. Moreover, the so-called 'Nuremberg Portrait' of Coiter served to illustrate his outstanding authority.

  5. ‘Nature Concocts & Expels’: The Agents and Processes of Recovery from Disease in Early Modern England

    PubMed Central

    Newton, Hannah

    2015-01-01

    The ‘golden saying’ in early modern medicine was ‘Nature is the healer of disease’. This article uncovers the meaning and significance of this forgotten axiom by investigating perceptions of the agents and physiological processes of recovery from illness in England, c.1580–1720. Drawing on sources such as medical texts and diaries, it shows that doctors and laypeople attributed recovery to three agents—God, Nature and the practitioner. While scholars are familiar with the roles of providence and medicine, the vital agency of Nature has been overlooked. In theory, the agents operated in a hierarchy: Nature was ‘God's instrument’, and the physician, ‘Nature's servant’; but in practice the power balance was more ambivalent. Nature was depicted both as a housewife who cooked and cleaned the humours, and as a warrior who defeated the disease. Through exploring these complex dynamics, the article sheds fresh light on concepts of gender, disease and bodies. PMID:26217069

  6. "Secrets of the female sex": Jane Sharp, the reproductive female body, and early modern midwifery manuals.

    PubMed

    Hobby, E

    2001-01-01

    Early modern midwifery manuals in Britain were usually the work of men. These books were a significant source of information about the body to the wider reading public: many sold well, and their prefatory materials include injunctions to readers not to make improper use of them. What is particularly interesting about Jane Sharp's Midwives Book (1671) is that it both provides a compendium of current beliefs concerning reproduction, and indicates the author's ironic perception of the misogyny that underpinned accepted ideas about the female reproductive body. This article gives key examples of Sharp's interventions, and also refers to Thomas Bartholin, Bartholinus Anatomy (1688); Richard Bunworth, The Doctresse (1656); Hugh Chamberlen, The Accomplisht Midwife (1673); The Compleat Midwifes Practice (1656); Helkiah Crooke, Microcosmographia (1615); Nicholas Culpeper, A Directory for Midwives (1651); Jacques Guillemeau, Childbirth (1612); Jean Riolan, A Sure Guide (1657); Daniel Sennert, Practical Physick (1664); William Sermon, The Ladies Companion (1671); and Percival Willughby, Observations in Midwifery (c. 1675).

  7. Did policies to abate atmospheric emissions from traffic have a positive effect in London?

    PubMed

    Font, Anna; Fuller, Gary W

    2016-11-01

    A large number of policy initiatives are being taken at the European level, across the United Kingdom and in London to improve air quality and reduce population exposure to harmful pollutants from traffic emissions. Trends in roadside increments of nitrogen oxides (NO X ), nitrogen dioxide (NO 2 ), particulate matter (PM), black carbon (CBLK) and carbon dioxide (CO 2 ) were examined at 65 London monitoring sites for two periods of time: 2005-2009 and 2010-2014. Between 2005 and 2009 there was an overall increase in NO 2 reflecting the growing evidence of real world emissions from diesel vehicles. Conversely, NO 2 decreased by 10%·year -1 from 2010 onwards along with PM 2.5 (-28%·year -1 ) and black carbon (-11%·year -1 ). Downwards trends in air pollutants were not fully explained by changes in traffic counts therefore traffic exhaust emission abatement policies were proved to be successful in some locations. PM 10 concentrations showed no significant overall change suggesting an increase in coarse particles which offset the decrease in tailpipe emissions; this was especially the case on roads in outer London where an increase in the number of Heavy Good Vehicles (HGVs) was seen. The majority of roads with increasing NO X experienced an increase in buses and coaches. Changes in CO 2 from 2010 onwards did not match the downward predictions from reduced traffic flows and improved fleet efficiency. CO 2 increased along with increasing HGVs and buses. Polices to manage air pollution provided differential benefits across London's road network. To investigate this, k-means clustering technique was applied to group roads which behaved similarly in terms of trends to evaluate the effectiveness of policies to mitigate traffic emissions. This is the first time that London's roadside monitoring sites have been considered as a population rather than summarized as a mean behaviour only, allowing greater insight into the differential changes in air pollution abatement

  8. "Delays and Vexation": Jack London and the Russo-Japanese War.

    ERIC Educational Resources Information Center

    Sweeney, Michael S.

    1998-01-01

    Contributes to scholarship on journalism history and censorship by discussing Jack London's efforts as a war correspondent to cover the Russo-Japanese War in Korea and Manchuria in 1904. Focuses on the difficulties he encountered as a result of systematic and highly restrictive censorship by the Japanese. (SR)

  9. Skin Colour Awareness and Preference in London Nursery School Children

    ERIC Educational Resources Information Center

    Laishley, Jenny

    1971-01-01

    Study focuses on children aged 3 to 5 years from 3 London areas. Contrary to expectation, awareness of differences in skin color was not a simple function of age and contact with colored children and adults; no clear evidence of prejudiced thinking was found in the subjects studied. (RJ)

  10. Interactions of neanderthals and modern humans: what can be inferred from mitochondrial DNA?

    PubMed

    Cyran, Krzysztof A; Kimmel, Marek

    2005-07-01

    This paper reviews the state-of-the-art knowledge concerning the relationship between Neanderthals and Upper Paleolithic modern humans. The branching-process method is applied to infer the upper limit of hypothetical Neanderthal admixture, consistent with the evidence based on mitochon- drial DNA sequences of contemporary modern humans, as well as Neanderthal and early modern European H. sapiens fossils. As a result, a maximum value of 15% admixture is obtained. This estimate is discussed in the context of its consequences for the two competing theories of modern human origin.

  11. Genetic evidence and the modern human origins debate.

    PubMed

    Relethford, J H

    2008-06-01

    A continued debate in anthropology concerns the evolutionary origin of 'anatomically modern humans' (Homo sapiens sapiens). Different models have been proposed to examine the related questions of (1) where and when anatomically modern humans first appeared and (2) the genetic and evolutionary relationship between modern humans and earlier human populations. Genetic data have been increasingly used to address these questions. Genetic data on living human populations have been used to reconstruct the evolutionary history of the human species by considering how global patterns of human variation could be produced given different evolutionary scenarios. Of particular interest are gene trees that reconstruct the time and place of the most recent common ancestor of humanity for a given haplotype and the analysis of regional differences in genetic diversity. Ancient DNA has also allowed a direct assessment of genetic variation in European Neandertals. Together with the fossil record, genetic data provide insight into the origin of modern humans. The evidence points to an African origin of modern humans dating back to 200,000 years followed by later expansions of moderns out of Africa across the Old World. What is less clear is what happened when these early modern humans met preexisting 'archaic human' populations outside of Africa. At present, it is difficult to distinguish between a model of total genetic replacement and a model that includes some degree of genetic mixture.

  12. Prise en compte des ``courants de London'' dans la modélisation des supraconducteurs

    NASA Astrophysics Data System (ADS)

    Bossavit, Alain

    1997-10-01

    A model is given, in variational form, in which volumic “Bean currents”, ruled by Bean's law, and surface “London currents” coexist. This macroscopic model generalizes Bean's one, by appending to the critical density j_c a second parameter, with the dimension of a length, similar to London's depth λ. The one-dimensional version of the model is investigated, in order to link this parameter with the standard observable H-M characteristics On propose un modèle, sous forme variationnelle, associant des “courants de Bean” volumiques, décrits par la loi de Bean, et des “courants de London”, surfaciques. Ce modèle macroscopique généralise celui de Bean, caractérisé par le courant critique j_c, et fait intervenir un second paramètre, homogène à une longueur, analogue au λ de London. La version unidimensionnelle du modèle est étudiée en détail de manière à relier ce paramètre à l'observation des caractéristiques H-M usuelles.

  13. The earliest unequivocally modern humans in southern China.

    PubMed

    Liu, Wu; Martinón-Torres, María; Cai, Yan-jun; Xing, Song; Tong, Hao-wen; Pei, Shu-wen; Sier, Mark Jan; Wu, Xiao-hong; Edwards, R Lawrence; Cheng, Hai; Li, Yi-yuan; Yang, Xiong-xin; de Castro, José María Bermúdez; Wu, Xiu-jie

    2015-10-29

    The hominin record from southern Asia for the early Late Pleistocene epoch is scarce. Well-dated and well-preserved fossils older than ∼45,000 years that can be unequivocally attributed to Homo sapiens are lacking. Here we present evidence from the newly excavated Fuyan Cave in Daoxian (southern China). This site has provided 47 human teeth dated to more than 80,000 years old, and with an inferred maximum age of 120,000 years. The morphological and metric assessment of this sample supports its unequivocal assignment to H. sapiens. The Daoxian sample is more derived than any other anatomically modern humans, resembling middle-to-late Late Pleistocene specimens and even contemporary humans. Our study shows that fully modern morphologies were present in southern China 30,000-70,000 years earlier than in the Levant and Europe. Our data fill a chronological and geographical gap that is relevant for understanding when H. sapiens first appeared in southern Asia. The Daoxian teeth also support the hypothesis that during the same period, southern China was inhabited by more derived populations than central and northern China. This evidence is important for the study of dispersal routes of modern humans. Finally, our results are relevant to exploring the reasons for the relatively late entry of H. sapiens into Europe. Some studies have investigated how the competition with H. sapiens may have caused Neanderthals' extinction (see ref. 8 and references therein). Notably, although fully modern humans were already present in southern China at least as early as ∼80,000 years ago, there is no evidence that they entered Europe before ∼45,000 years ago. This could indicate that H. neanderthalensis was indeed an additional ecological barrier for modern humans, who could only enter Europe when the demise of Neanderthals had already started.

  14. [Academy idea and Curiositas as leitmotif of the early modern Leopoldina].

    PubMed

    Boehm, Laetitia

    2008-01-01

    , it deals with aspects of privilege law, regarding the development of new kinds of higher learning institutions and university politics in the imperial city in the confessional era ("Semi-Universities"/"Academies" Strassburg, Nuremberg-Altdorf). This is followed by a thematic balancing.--Chapter III. Curiositas as an Early Modern Leitmotif of Natural Science Academies refers first to the multivalent popular usage of the fashionable and borrowed German word "Kuriosität" [curiosity] during the Enlightenment, then inquires about the word's original definitions in ancient and medieval scholarly traditions. In the age of humanist source study and expeditions into "new worlds", the concept of curiositas as an (ethically ambivalent) "desire for knowledge" was revitalized; this is exemplified by two types of sources: the report of the Orient and Brazil explorer André Thevet and the literarily virulent figure (around 1600) of knowledge-thirsty Faust. A reexamination of the academy's foundational documents, in conjunction with the peregrinatio academica of Schweinfurt doctors to Italy, confirms the old question, now newly posed, about the methodological and programmatic signal of the curiositas device. The self-reflection of the naturae-curiosi and their focus on observational development and natural-historical classifications in the area of "materia medica" show--besides other advances in scholarship in the early 17th century--clear correlation with the "phenomenology of modern thought" that is so often discussed today. However, there must be an evolutionary and innovative differentiation from what would later be called "natural science" disciplines (like biology, zoology, mineralogy, chemistry), as opposed to an all-inclusively defined "scientific revolution", which pertains to astronomical and mathematical ways of thinking, as well as new insights in the physical-instrumental field.--Chapter IV. The Urban Medical Profession Between Scholarly Medicine and Practice applies

  15. Drastic reduction in the growth temperature of graphene on copper via enhanced London dispersion force

    PubMed Central

    Choi, Jin-Ho; Li, Zhancheng; Cui, Ping; Fan, Xiaodong; Zhang, Hui; Zeng, Changgan; Zhang, Zhenyu

    2013-01-01

    London dispersion force is ubiquitous in nature, and is increasingly recognized to be an important factor in a variety of surface processes. Here we demonstrate unambiguously the decisive role of London dispersion force in non-equilibrium growth of ordered nanostructures on metal substrates using aromatic source molecules. Our first-principles based multi-scale modeling shows that a drastic reduction in the growth temperature, from ~1000°C to ~300°C, can be achieved in graphene growth on Cu(111) when the typical carbon source of methane is replaced by benzene or p-Terphenyl. The London dispersion force enhances their adsorption energies by about (0.5–1.8) eV, thereby preventing their easy desorption, facilitating dehydrogenation, and promoting graphene growth at much lower temperatures. These quantitative predictions are validated in our experimental tests, showing convincing demonstration of monolayer graphene growth using the p-Terphenyl source. The general trends established are also more broadly applicable in molecular synthesis of surface-based nanostructures. PMID:23722566

  16. Global sport mega-events and the politics of mobility: the case of the London 2012 Olympics.

    PubMed

    Giulianotti, Richard; Armstrong, Gary; Hales, Gavin; Hobbs, Dick

    2015-03-01

    This paper examines the politics of mobility which surrounded the London 2012 Olympics. We provide a critical discussion of the mobility conflicts, problems and criticisms which emerged from our research with local people in the Stratford and wider Newham areas of London, where most Olympic events were located. The paper is divided into four broad parts. First, we identify and discuss the relevant components of the 'mobilities paradigm' in social science which underpin our analysis. Second, we briefly outline our research methods, centring particularly on fieldwork and interviews with different social groups. Third, we examine in detail the six main themes of mobility politics which were evident at London 2012, relating to social context, event construction, event mobility systems, commercial mobilities, the mobile politics of exclusion, and contested modes of mobility. In doing so, we seek to extend the mobilities paradigm by introducing various concepts and keywords - notably on the three-speed city, entryability, mobility panics, instrumental mobility, and corporate kettling - which may be utilized by social scientists to examine mobility systems in other social contexts. We conclude by reaffirming the significance of mobility-focused research at sport and other mega-events, and by indicating future lines of inquiry for social scientists. © London School of Economics and Political Science 2014.

  17. The early modern kidney--nephrology in and about the nineteenth century. Part 1.

    PubMed

    Eknoyan, Garabed

    2013-01-01

    The 19th century was a period of momentous scientific discoveries, technological achievements, and societal changes. A beneficiary of these revolutionary upheavals was medical empiricism that supplanted the rationalism of the past giving rise to early modern scientific medicine. Continued reliance on sensory data now magnified by technical advances generated new medical information that could be quantified with increasing precision, verified by repeated experimentation, and validated by statistical analysis. The institutionalization and integration of these methodologies into medical education were a defining step that assured their progress and perpetuation. Major advances were made in the nosography of diseases of the kidney, notably that of the diagnosis of progressive kidney disease from the presence of albuminuria by Richard Bright (1789-1858); and of renal structure and function, notably the demonstration of the continuity of the glomerular capsule with the tubular basement membrane by William Bowman (1816-1892), and the arguments for hemodynamic physical forces mediated glomerular filtration by Carl Ludwig (1816-1895) and for active tubular transport by Rudolf Heidenhain (1834-1897). Improvements in microscopy and tissue processing were instrumental in describing the cellular ultrastructure of the glomerulus and tubular segments, but their integrated function remained to be elucidated. The kidney continued to be considered a tubular secretory organ and its pathology attributed to injury of the interstitium (interstitial nephritis) or tubules (parenchymatous nephritis). © 2012 Wiley Periodicals, Inc.

  18. Major Greenwood's early career and the first departments of medical statistics.

    PubMed

    Farewell, Vern; Johnson, Tony

    2014-06-15

    Major Greenwood was the foremost medical statistician of the first half of the 20th century in the UK and is often credited with founding the first department of medical statistics at the Lister Institute in London in 1910. Here, we examine in detail his career prior to this appointment, including his association with Karl Pearson. We also examine the remit of the Department of Medical Statistics at the London Hospital of which he was the founding Director in 1908, some 2 years earlier than his appointment at the Lister Institute. Supporting information consisting of further details about Major Greenwood's early career, biographical articles and obituaries for him, and a list of his publications to 1910 by year, is also provided. © 2014 The Authors. Statistics in Medicine published by John Wiley & Sons, Ltd.

  19. Domesticating Biotechnology: How London's Science Museum Has Framed the Controversy.

    ERIC Educational Resources Information Center

    Levidow, Les

    1998-01-01

    Exhibits in London's Science Museum are critiqued in this discussion of the problem of balance in presenting controversial issues in museum exhibits. Science museums claim to portray controversial issues in a neutral manner, but neutrality is impossible. Asks how science museums can involve visitors in the controversy and how the museum's role can…

  20. American Modern Design for a New Age.

    ERIC Educational Resources Information Center

    Johnson, Mark M.

    2000-01-01

    Focuses on the exhibition titled "American Modern, 1925-1940: Design for a New Age" that documents the efforts and achievements of the United States in the area of design arts. States that the exhibition features more than 150 objects, including furniture, posters, and radios, by leading designers of the early and mid century. (CMK)

  1. Third Generation Gangs Revisited: The Iraq Insurgency

    DTIC Science & Technology

    2005-09-01

    9 Ian F.W. Beckett , Modern Insurgencies and Counter-insurgencies (London: Routledge, 2001), 70. 10 Ibid, 74. 11 Steven Metz and Raymond Millen...Intensity Conflict,” RAND Corporation (Santa Monica, CA, 1991), 34. 15 Ibid, 21. 16 Ibid, 13. 17 Ian F.W. Beckett , Modern Insurgencies and Counter...Argentina’s Lost Patrol (Yale University Press, 1995), 84. 25 Ian F.W. Beckett , Modern Insurgencies and Counter-insurgencies (London: Routledge, 2001

  2. Relativistic theory of nuclear spin-rotation tensor with kinetically balanced rotational London orbitals

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xiao, Yunlong; Zhang, Yong; Liu, Wenjian, E-mail: liuwjbdf@gmail.com

    2014-10-28

    Both kinetically balanced (KB) and kinetically unbalanced (KU) rotational London orbitals (RLO) are proposed to resolve the slow basis set convergence in relativistic calculations of nuclear spin-rotation (NSR) coupling tensors of molecules containing heavy elements [Y. Xiao and W. Liu, J. Chem. Phys. 138, 134104 (2013)]. While they perform rather similarly, the KB-RLO Ansatz is clearly preferred as it ensures the correct nonrelativistic limit even with a finite basis. Moreover, it gives rise to the same “direct relativistic mapping” between nuclear magnetic resonance shielding and NSR coupling tensors as that without using the London orbitals [Y. Xiao, Y. Zhang, andmore » W. Liu, J. Chem. Theory Comput. 10, 600 (2014)].« less

  3. The Well London program - a cluster randomized trial of community engagement for improving health behaviors and mental wellbeing: baseline survey results

    PubMed Central

    2012-01-01

    Background The Well London program used community engagement, complemented by changes to the physical and social neighborhood environment, to improve physical activity levels, healthy eating, and mental wellbeing in the most deprived communities in London. The effectiveness of Well London is being evaluated in a pair-matched cluster randomized trial (CRT). The baseline survey data are reported here. Methods The CRT involved 20 matched pairs of intervention and control communities (defined as UK census lower super output areas (LSOAs); ranked in the 11% most deprived LSOAs in London by the English Indices of Multiple Deprivation) across 20 London boroughs. The primary trial outcomes, sociodemographic information, and environmental neighbourhood characteristics were assessed in three quantitative components within the Well London CRT at baseline: a cross-sectional, interviewer-administered adult household survey; a self-completed, school-based adolescent questionnaire; a fieldworker completed neighborhood environmental audit. Baseline data collection occurred in 2008. Physical activity, healthy eating, and mental wellbeing were assessed using standardized, validated questionnaire tools. Multiple imputation was used to account for missing data in the outcomes and other variables in the adult and adolescent surveys. Results There were 4,107 adults and 1,214 adolescent respondents in the baseline surveys. The intervention and control areas were broadly comparable with respect to the primary outcomes and key sociodemographic characteristics. The environmental characteristics of the intervention and control neighborhoods were broadly similar. There was greater between-cluster variation in the primary outcomes in the adult population compared to the adolescent population. Levels of healthy eating, smoking, and self-reported anxiety/depression were similar in the Well London adult population and the national Health Survey for England. Levels of physical activity were higher

  4. The Well London program--a cluster randomized trial of community engagement for improving health behaviors and mental wellbeing: baseline survey results.

    PubMed

    Phillips, Gemma; Renton, Adrian; Moore, Derek G; Bottomley, Christian; Schmidt, Elena; Lais, Shahana; Yu, Ge; Wall, Martin; Tobi, Patrick; Frostick, Caroline; Clow, Angela; Lock, Karen; Petticrew, Mark; Hayes, Richard

    2012-07-06

    The Well London program used community engagement, complemented by changes to the physical and social neighborhood environment, to improve physical activity levels, healthy eating, and mental wellbeing in the most deprived communities in London. The effectiveness of Well London is being evaluated in a pair-matched cluster randomized trial (CRT). The baseline survey data are reported here. The CRT involved 20 matched pairs of intervention and control communities (defined as UK census lower super output areas (LSOAs); ranked in the 11% most deprived LSOAs in London by the English Indices of Multiple Deprivation) across 20 London boroughs. The primary trial outcomes, sociodemographic information, and environmental neighbourhood characteristics were assessed in three quantitative components within the Well London CRT at baseline: a cross-sectional, interviewer-administered adult household survey; a self-completed, school-based adolescent questionnaire; a fieldworker completed neighborhood environmental audit. Baseline data collection occurred in 2008. Physical activity, healthy eating, and mental wellbeing were assessed using standardized, validated questionnaire tools. Multiple imputation was used to account for missing data in the outcomes and other variables in the adult and adolescent surveys. There were 4,107 adults and 1,214 adolescent respondents in the baseline surveys. The intervention and control areas were broadly comparable with respect to the primary outcomes and key sociodemographic characteristics. The environmental characteristics of the intervention and control neighborhoods were broadly similar. There was greater between-cluster variation in the primary outcomes in the adult population compared to the adolescent population. Levels of healthy eating, smoking, and self-reported anxiety/depression were similar in the Well London adult population and the national Health Survey for England. Levels of physical activity were higher in the Well London adult

  5. Pseudoislets as primary islet replacements for research: report on a symposium at King's College London, London UK.

    PubMed

    Persaud, Shanta J; Arden, Catherine; Bergsten, Peter; Bone, Adrian J; Brown, James; Dunmore, Simon; Harrison, Moira; Hauge-Evans, Astrid; Kelly, Catriona; King, Aileen; Maffucci, Tania; Marriott, Claire E; McClenaghan, Neville; Morgan, Noel G; Reers, Christina; Russell, Mark A; Turner, Mark D; Willoughby, Emma; Younis, Mustafa Y G; Zhi, Z L; Jones, Peter M

    2010-01-01

    Laboratory-based research aimed at understanding processes regulating insulin secretion and mechanisms underlying β-cell dysfunction and loss in diabetes often makes use of rodents, as these processes are in many respects similar between rats/mice and humans. Indeed, a rough calculation suggests that islets have been isolated from as many as 150,000 rodents to generate the data contained within papers published in 2009 and the first four months of 2010. Rodent use for islet isolation has been mitigated, to a certain extent, by the availability of a variety of insulin-secreting cell lines that are used by researchers world-wide. However, when maintained as monolayers the cell lines do not replicate the robust, sustained secretory responses of primary islets which limits their usefulness as islet surrogates. On the other hand, there have been several reports that configuration of MIN6 β-cells, derived from a mouse insulinoma, as three-dimensional cell clusters termed ‘pseudoislets’ largely recapitulates the function of primary islet β-cells. The Diabetes Research Group at King’s College London has been using the MIN6 pseudoislet model for over a decade and they hosted a symposium on “Pseudoislets as primary islet replacements for research”, which was funded by the UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), in London on 15th and 16th April 2010. This small, focused meeting was conceived as an opportunity to consolidate information on experiences of working with pseudoislets between different UK labs, and to introduce the theory and practice of pseudoislet culture to laboratories working with islets and/or β-cell lines but who do not currently use pseudoislets. This short review summarizes the background to the development of the cell line-derived pseudoislet model, the key messages arising from the symposium and emerging themes for future pseudoislet research.

  6. A Dental Prosthesis from the Early Modern Age in Tuscany (Italy).

    PubMed

    Minozzi, Simona; Panetta, Daniele; De Sanctis, Massimo; Giuffra, Valentina

    2017-04-01

    During archaeological excavation, carried out in the S. Francesco Monastery at Lucca (Tuscany, Italy), a golden dental appliance was discovered. The prosthesis was found, together with commingled human remains, in the collective tomb of the aristocratic family of the Guinigi, a powerful family who governed Lucca from 1392 until 1429. The exact archaeological dating of the prosthesis was not possible, but some elements suggest a dating to the beginning of the 17th century. Aim of the paper is to study and describe the dental appliance trough a multidisciplinary approach. Macroscopical and micro-CT examinations were performed to investigate the technics used for the realization of the dental prosthesis. SEM analysis was performed to study alloy composition of the metallic fixing lamina and microstructure of the deposits on the dental surface. The dental prosthesis consists in five mandibular teeth: three central incisors and two lateral canines linked together by a golden band inserted into the dental roots to replace the anterior arch of the jaw. Micro-CT scan revealed the presence of two small golden pins inserted into each tooth crossing the root and fixing the teeth to the internal gold band. SEM examination of the lamina indicated a homogeneous composition, with average contents of 73 wt% gold, 15.6 wt% Ag, and 11.4 wt% Cu. Apposition of dental calculus on the teeth indicated that the prosthesis had been worn for a long period. This dental prosthesis provides a unique finding of technologically advanced dentistry in this period. In fact, during the Early Modern Age, some authors described gold band technology for the replacement of missing teeth; nevertheless, no direct evidences of these devices have been brought to light up so far. © 2016 Wiley Periodicals, Inc.

  7. Impact of the London 2012 Olympic and Paralympic Games on demand for microbiology gastrointestinal diagnostic services at the Public Health Laboratory London.

    PubMed

    Williams, K; Sinclair, C; McEwan, R; Fleet, K; Balasegaram, S; Manuel, R

    2014-07-01

    Planning for the London 2012 Olympic and Paralympic Games at the Public Health Laboratory London was based on the requirement to meet potential increased demand with scalable capacity. The aim of this study was to determine the impact on demand for microbiology gastrointestinal diagnostic services during the Games period. Retrospective cross-sectional time-series data analysis was used to assess the number of gastrointestinal specimens received in the laboratory and the number of positive results. There was no increase in the number of gastrointestinal specimens received during the Games period, thus the Games had no impact on demand for microbiology gastrointestinal diagnostic services at the laboratory. There was a decrease in the number of public health specimens received for culture [incidence rate ratio = 0.34, 95% confidence interval (CI) = 0.13-0.86, P = 0.02] and a decrease in the number of culture positive community specimens (odds ratio = 0.59, 95 % CI = 0.40-0.85, P = 0.005), suggesting a decrease in gastrointestinal illness during the Games period. As previous planning assumptions were not based on actual specimen activity, the results of this study may modify the extent of additional planning for microbiological services required for mass gatherings. © 2014 The Authors.

  8. Aircraft noise and cardiovascular disease near Heathrow airport in London: small area study.

    PubMed

    Hansell, Anna L; Blangiardo, Marta; Fortunato, Lea; Floud, Sarah; de Hoogh, Kees; Fecht, Daniela; Ghosh, Rebecca E; Laszlo, Helga E; Pearson, Clare; Beale, Linda; Beevers, Sean; Gulliver, John; Best, Nicky; Richardson, Sylvia; Elliott, Paul

    2013-10-08

    To investigate the association of aircraft noise with risk of stroke, coronary heart disease, and cardiovascular disease in the general population. Small area study. 12 London boroughs and nine districts west of London exposed to aircraft noise related to Heathrow airport in London. About 3.6 million residents living near Heathrow airport. Risks for hospital admissions were assessed in 12 110 census output areas (average population about 300 inhabitants) and risks for mortality in 2378 super output areas (about 1500 inhabitants). Risk of hospital admissions for, and mortality from, stroke, coronary heart disease, and cardiovascular disease, 2001-05. Hospital admissions showed statistically significant linear trends (P<0.001 to P<0.05) of increasing risk with higher levels of both daytime (average A weighted equivalent noise 7 am to 11 pm, L(Aeq),16 h) and night time (11 pm to 7 am, Lnight) aircraft noise. When areas experiencing the highest levels of daytime aircraft noise were compared with those experiencing the lowest levels (>63 dB v ≤ 51 dB), the relative risk of hospital admissions for stroke was 1.24 (95% confidence interval 1.08 to 1.43), for coronary heart disease was 1.21 (1.12 to 1.31), and for cardiovascular disease was 1.14 (1.08 to 1.20) adjusted for age, sex, ethnicity, deprivation, and a smoking proxy (lung cancer mortality) using a Poisson regression model including a random effect term to account for residual heterogeneity. Corresponding relative risks for mortality were of similar magnitude, although with wider confidence limits. Admissions for coronary heart disease and cardiovascular disease were particularly affected by adjustment for South Asian ethnicity, which needs to be considered in interpretation. All results were robust to adjustment for particulate matter (PM10) air pollution, and road traffic noise, possible for London boroughs (population about 2.6 million). We could not distinguish between the effects of daytime or night time

  9. Looking into 'London'

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This mosaic image from the microscopic imager on the Mars Exploration Rover Opportunity shows the rock abrasion tool target, 'London.' The image was taken by the Mars Exploration Rover Opportunity on its 149th sol on Mars (June 24, 2004). Scientists 'read' the geology of the image from bottom to top, with the youngest material pictured at the bottom of the image and the oldest material in the layers pictured at the top. Millimeter-scale layers run horizontally across the exposed surface, with two sliced sphere-like objects, or 'blueberries' on the upper left and upper right sides of the impression. This material is similar to the evaporative material found in 'Eagle Crater.' However, the intense review of these layers in Endurance Crater is, in essence, deepening the water story authored by ancient Mars.

    In Eagle Crater, the effects of water were traced down a matter of centimeters. Endurance Crater's depth has allowed the tracing of water's telltale marks up to meters. Another process that significantly affects martian terrain is muddying the water story a bit. Although it is clear that the layers in Endurance were affected by water, it is also evident that Aeolian, or wind, processes have contributed to the makeup of the crater.

  10. Language Shift and Vitality Perceptions amongst London's Second-Generation Bangladeshis

    ERIC Educational Resources Information Center

    Rasinger, Sebastian M.

    2013-01-01

    With more than 64,500 members, the Bangladeshi community in London is one of the largest in the UK. Originating from a wave of immigration during the 1970s, a considerable part of the community now consists of a second, UK-born generation. This explorative study seeks to address, first, the extent of the intergenerational language shift from…

  11. Desensitisation to cigarette package graphic health warnings: a cohort comparison between London and Singapore

    PubMed Central

    Ratneswaran, Culadeeban; Chisnall, Ben; Li, Mingyue; Tan, Sarah; Douiri, Abdel; Anantham, Devanand; Steier, Joerg

    2016-01-01

    Objectives We compared 2 sociocultural cohorts with different duration of exposure to graphic health warning labels (GHWL), to investigate a possible desensitisation to their use. We further studied how a differing awareness and emotional impact of smoking-associated risks could be used to prevent this. Setting Structured interviews of patients from the general respiratory department were undertaken between 2012 and 2013 in 2 tertiary hospitals in Singapore and London. Participants 266 participants were studied, 163 Londoners (35% smokers, 54% male, age 52±18 years) and 103 Singaporeans (53% smokers, p=0.003; 78% male, p<0.001; age 58±15 years, p=0.012). Main outcomes and measures 50 items assessed demographics, smoking history, knowledge and the deterring impact of smoking-associated risks. After showing 10 GHWL, the impact on emotional response, cognitive processing and intended smoking behaviour was recorded. Results Singaporeans scored lower than the Londoners across all label processing constructs, and this was consistent for the smoking and non-smoking groups. Londoners experienced more ‘disgust’ and felt GHWL were more effective at preventing initiation of, or quitting, smoking. Singaporeans had a lower awareness of lung cancer (82% vs 96%, p<0.001), despite ranking it as the most deterring consequence of smoking. Overall, ‘blindness’ was the least known potential risk (28%), despite being ranked as more deterring than ‘stroke’ and ‘oral cancer’ in all participants. Conclusions The length of exposure to GHWL impacts on the effectiveness. However, acknowledging the different levels of awareness and emotional impact of smoking-associated risks within different sociocultural cohorts could be used to maintain their impact. PMID:27798017

  12. Stress, sex, and plague: Patterns of developmental stress and survival in pre- and post-Black Death London.

    PubMed

    DeWitte, Sharon N

    2018-01-01

    Previous research revealed declines in survivorship in London before the Black Death (c. 1346-1353), and improvements in survivorship following the epidemic. These trends indicate that there were declines in general levels of health before the Black Death and improvements thereof afterwards. This study expands on previous research by examining whether changes in survivorship were consistent between the sexes, and how patterns of developmental stress markers changed before and after the Black Death. This study uses samples from London cemeteries dated to one of three periods: Early Pre-Black Death (1000-1200 AD, n = 255), Late Pre-Black Death (1200-1250 AD, n = 247), or Post-Black Death (1350-1540 AD n = 329). Temporal trends in survivorship are assessed via Kaplan-Meier survival analysis, and trends in tibial length (as a proxy for stature) and linear enamel hypoplasia (LEH) are assessed using t-tests and Chi-square tests, respectively. Survivorship for both sexes decreased before the Black Death and increased afterwards. For males, LEH frequencies increased and stature decreased before the epidemic, and LEH declined and stature increased after the Black Death. For females, the only significant change with respect to developmental stress markers was a decrease in stature after the Black Death. These results might reflect variation between the sexes in sensitivity to stressors, the effects of nutrition on pubertal timing, disproportionate access to dietary resources for males in the aftermath of the Black Death, the disproportionate deaths of frail individuals during the epidemic, or some combination of these factors. © 2017 Wiley Periodicals, Inc.

  13. Evolution of computational chemistry, the "launch pad" to scientific computational models: The early days from a personal account, the present status from the TACC-2012 congress, and eventual future applications from the global simulation approach

    NASA Astrophysics Data System (ADS)

    Clementi, Enrico

    2012-06-01

    This is the introductory chapter to the AIP Proceedings volume "Theory and Applications of Computational Chemistry: The First Decade of the Second Millennium" where we discuss the evolution of "computational chemistry". Very early variational computational chemistry developments are reported in Sections 1 to 7, and 11, 12 by recalling some of the computational chemistry contributions by the author and his collaborators (from late 1950 to mid 1990); perturbation techniques are not considered in this already extended work. Present day's computational chemistry is partly considered in Sections 8 to 10 where more recent studies by the author and his collaborators are discussed, including the Hartree-Fock-Heitler-London method; a more general discussion on present day computational chemistry is presented in Section 14. The following chapters of this AIP volume provide a view of modern computational chemistry. Future computational chemistry developments can be extrapolated from the chapters of this AIP volume; further, in Sections 13 and 15 present an overall analysis on computational chemistry, obtained from the Global Simulation approach, by considering the evolution of scientific knowledge confronted with the opportunities offered by modern computers.

  14. Enduring consequences of terrorism: 7-month follow-up survey of reactions to the bombings in London on 7 July 2005.

    PubMed

    Rubin, G James; Brewin, Chris R; Greenberg, Neil; Hughes, Jamie Hacker; Simpson, John; Wessely, Simon

    2007-04-01

    Terrorist attacks can have psychological effects on the general public. To assess the medium-term effects of the July 2005 London bombings on the general population in London and to identify risk factors for persistent effects. We telephoned 1010 Londoners 11-13 days after the bombings to assess stress levels, perceived threat and travel intentions. Seven months later, 574 respondents were contacted again and asked similar questions, and questions concerning altered perceptions of self and the world. ;Substantial stress' (11%), perceived threat to self (43%) and reductions in travel because of the bombings (19%) persisted at a reduced level; other perceived threats remained unchanged. A more negative world view was common. Other than degree of exposure to the bombings, there were no consistent predictors of which people with short-term reactions would develop persistent reactions. A longer-term impact of terrorism on the perceptions and behaviour of Londoners was documented.

  15. J. Jeans' idealism about space and its influences on E.A. Milne at the dawn of modern cosmology

    NASA Astrophysics Data System (ADS)

    Macchia, Giovanni

    2014-05-01

    This paper deals with two important English scientists of the first half of the twentieth century: Edward Arthur Milne and James Hopwood Jeans. It examines the philosophical reasons that, in 1932, induced Milne to devote himself to the newborn modern cosmology. Among those reasons, it is argued that the most important ones were some of Jeans' philosophical statements regarding the new relativistic view of the expanding universe. In particular, Milne reacted to some confusing idealist opinions expressed by Jeans in the London newspaper The Times, in May 1932, in a debate on the expansion of the universe. Actually, as it will be shown, Jeans received many criticisms about the philosophical reasonings present in all of his popularizing works.

  16. Lessons for climate policy from The Great Stink of London

    NASA Astrophysics Data System (ADS)

    Skuce, A.

    2012-12-01

    A rapidly growing population and the introduction of the flush toilet in nineteenth-century London caused a crisis with sewage pollution in the River Thames (Halliday, 1999). There were decades of delays in implementing solutions owing to: inadequate governance institutions; political inertia; difficulties with financing; opposition from vested interests; scientific uncertainties; and technological challenges. Effective counter-measures were started only once the problem arose, quite literally, under the noses of parliamentarians. There are parallels, some of them pointed out earlier by Alley et al (2010), between the sewage crisis in Victorian London and the current problem with climate change. Both involve the unsustainable use of a common resource (a river, the atmosphere) for the unconstrained disposal of human waste products. Alley (2011) estimated that the costs of providing clean water and sanitation are comparable to the expected costs of reducing greenhouse gas emissions. Despite the similarities, the climate change issue is actually much more difficult because of: a) the unequal and uncertain global distribution of cause and effect; b) its long, intergenerational time lines; c) the insufficiency of adequate institutions, conventions or the tools— political, moral or economic—for tackling the climate crisis. This analysis is consistent with the model proposed by Gardiner (2011) in his book A Perfect Moral Storm. The three "storms" he identifies, the global, intergenerational and theoretical storms, combine in a powerful synergy to create a challenge of unprecedented intractability, providing opportunities for what Gardiner calls moral corruption: the obscuring of the buck-passing and procrastination that characterizes climate policy today. In Victorian London, the crucial steps to solve the sewage crises were not taken until the stench from the River Thames during the hot summer of 1858 rendered the House of Commons uninhabitable. A greater stink of a

  17. The turning point from an archaic Arab medical system to an early modern European system in Jerusalem according to the Swiss physician Titus Tobler (1806-77).

    PubMed

    Lev, Efraim; Amar, Zohar

    2004-01-01

    Until the end of the Ottoman period the Hippocratic-Galenic doctrine, which had been improved by medieval Muslim medicine, was the pre-dominant medicine in the Holy Land. The penetration of modern medicine into the region was a slow process, advancing step by step over the years until it was established around the end of the 19th century.Dr. Titus Tobler, a Swiss physician of many talents, first visited Jerusalem in 1835, then again in 1845, 1857, and 1865. He reported his experiences and impressions in several books and articles. His publications portray the condition of medicine in the city before the advent of European physicians, their arrival, and the establishment of the first hospitals in the city. Thanks to his endeavours, a professional description of the medical conditions prevailing in Jerusalem in the mid-19th century is available to the public. Tobler's writings include descriptions of the healers, blood-letters, quacks, medicinal substances and their market, and the diseases and illnesses from which the inhabitants suffered. In addition, Tobler produced a detailed report of the different hospitals, pharmacies, European physicians, and their experiences. A digest of Tobler's information, its fresh systematic arrangement, and its comparison with other historical sources, early as well as recent, produces a better picture than ever previously available of the medical conditions of the city in the final years of the ascendancy of Arab medical systems and in the early stages of early modern European medicine in Jerusalem and the Holy Land.

  18. Breathlessness during daily activity: The psychometric properties of the London Chest Activity of Daily Living Scale in patients with advanced disease and refractory breathlessness.

    PubMed

    Reilly, Charles C; Bausewein, Claudia; Garrod, Rachel; Jolley, Caroline J; Moxham, John; Higginson, Irene J

    2017-10-01

    The London Chest Activities of Daily Living Scale measures the impact of breathlessness on both activity and social functioning. However, the London Chest Activities of Daily Living Scale is not routinely used in patients with advanced disease. To assess the psychometric properties of the London Chest Activities of Daily Living Scale in patients with refractory breathlessness due to advanced disease. A cross-sectional secondary analysis of data from a randomised controlled parallel-group, pragmatic, single-blind fast-track trial (randomised controlled trial) investigating the effectiveness of an integrated palliative and respiratory care service for patients with advanced disease and refractory breathlessness, known as the Breathlessness Support Service (NCT01165034). All patients completed the following questionnaires: the London Chest Activities of Daily Living Scale, Chronic Respiratory Questionnaire, the Palliative care Outcome Scale, Palliative care Outcome Scale-symptoms, the Hospital Anxiety and Depression Scale and breathlessness measured on a numerical rating scale. Data quality, scaling assumptions, acceptability, internal consistency and construct validity of the London Chest Activities of Daily Living Scale were determined using standard psychometric approaches. Breathless patients with advanced malignant and non-malignant disease. A total of 88 patients were studied, primary diagnosis included; chronic obstructive pulmonary disease = 53, interstitial lung disease = 17, cancer = 18. Median (range) London Chest Activities of Daily Living Scale total score was 46.5 (14-67). No floor or ceiling effect was observed for the London Chest Activities of Daily Living Scale total score. Internal consistency was good, and Cronbach's alpha for the London Chest Activities of Daily Living Scale total score was 0.90. Construct validity was good with 13 out of 15 a priori hypotheses met. Psychometric analyses suggest that the London Chest Activities of Daily Living

  19. Breathlessness during daily activity: The psychometric properties of the London Chest Activity of Daily Living Scale in patients with advanced disease and refractory breathlessness

    PubMed Central

    Reilly, Charles C; Bausewein, Claudia; Garrod, Rachel; Jolley, Caroline J; Moxham, John; Higginson, Irene J

    2016-01-01

    Background: The London Chest Activities of Daily Living Scale measures the impact of breathlessness on both activity and social functioning. However, the London Chest Activities of Daily Living Scale is not routinely used in patients with advanced disease. Aim: To assess the psychometric properties of the London Chest Activities of Daily Living Scale in patients with refractory breathlessness due to advanced disease. Design: A cross-sectional secondary analysis of data from a randomised controlled parallel-group, pragmatic, single-blind fast-track trial (randomised controlled trial) investigating the effectiveness of an integrated palliative and respiratory care service for patients with advanced disease and refractory breathlessness, known as the Breathlessness Support Service (NCT01165034). All patients completed the following questionnaires: the London Chest Activities of Daily Living Scale, Chronic Respiratory Questionnaire, the Palliative care Outcome Scale, Palliative care Outcome Scale–symptoms, the Hospital Anxiety and Depression Scale and breathlessness measured on a numerical rating scale. Data quality, scaling assumptions, acceptability, internal consistency and construct validity of the London Chest Activities of Daily Living Scale were determined using standard psychometric approaches. Setting/participants: Breathless patients with advanced malignant and non-malignant disease. Results: A total of 88 patients were studied, primary diagnosis included; chronic obstructive pulmonary disease = 53, interstitial lung disease = 17, cancer = 18. Median (range) London Chest Activities of Daily Living Scale total score was 46.5 (14–67). No floor or ceiling effect was observed for the London Chest Activities of Daily Living Scale total score. Internal consistency was good, and Cronbach’s alpha for the London Chest Activities of Daily Living Scale total score was 0.90. Construct validity was good with 13 out of 15 a priori hypotheses met. Conclusion

  20. Modern Languages and Interculturality in the Primary Sector in England, Greece, Italy and Spain.

    ERIC Educational Resources Information Center

    Cerezal, Fernando

    1997-01-01

    Addresses concerns and issues regarding modern language teaching and learning at primary schools in Greece, Italy, Spain, and England. It focuses on the optimal age for learning and acquiring languages and to the educational reforms which have been undertaken in each country relating to early modern language teaching and learning and…

  1. "Varmits and Turnips": Personal Experiences of a Secondary Modern Education, 1958-1962

    ERIC Educational Resources Information Center

    Black, John

    2013-01-01

    This article is not intended to be an autobiography. It relates to the experiences of the author as a pupil in a secondary modern school in Wiltshire during the late 1950s and early 1960s. He suffered the experience of being an 11-plus failure and a secondary modern graduate at the age of 15 years. Later in life he had a much more rewarding career…

  2. The decline of adult smallpox in eighteenth-century London.

    PubMed

    Davenport, Romola; Schwarz, Leonard; Boulton, Jeremy

    2011-01-01

    Smallpox was probably the single most lethal disease in eighteenth-century Britain, but was a minor cause of death by the mid-nineteenth century. Although vaccination was crucial to the decline of smallpox, especially in urban areas, from the beginning of the nineteenth century, it remains disputed the extent to which smallpox mortality declined before vaccination. Analysis of age-specific changes in smallpox burials within the large west London parish of St Martin-in-the-Fields revealed a precipitous reduction in adult smallpox risk from the 1770s, and this pattern was duplicated in the east London parish of St Dunstan's. Most adult smallpox victims were rural migrants, and such a drop in their susceptibility is consistent with a sudden increase in exposure to smallpox in rural areas. We investigated whether this was due to the spread of inoculation, or an increase in smallpox transmission, using changes in the age patterns of child smallpox burials. Smallpox mortality rose among infants, and smallpox burials became concentrated at the youngest ages, suggesting a sudden increase in infectiousness of the smallpox virus. Such a change intensified the process of smallpox endemicization in the English population, but also made cities substantially safer for young adult migrants.

  3. Integrated care pilot in north-west London: a mixed methods evaluation

    PubMed Central

    Curry, Natasha; Harris, Matthew; Gunn, Laura H.; Pappas, Yannis; Blunt, Ian; Soljak, Michael; Mastellos, Nikolaos; Holder, Holly; Smith, Judith; Majeed, Azeem; Ignatowicz, Agnieszka; Greaves, Felix; Belsi, Athina; Costin-Davis, Nicola; Jones Nielsen, Jessica D.; Greenfield, Geva; Cecil, Elizabeth; Patterson, Susan; Car, Josip; Bardsley, Martin

    2013-01-01

    Introduction This paper provides the results of a year-long evaluation of a large-scale integrated care pilot in north-west London. The pilot aimed to integrate care across primary, acute, community, mental health and social care for people with diabetes and/or those aged 75+ through care planning, multidisciplinary case reviews, information sharing and project management support. Methods The evaluation team conducted qualitative studies of change at organisational, clinician and patient levels (using interviews, focus groups and a survey); and quantitative analysis of change in service use and patient-level clinical outcomes (using patient-level datasets and a matched control study). Results The pilot had successfully engaged provider organisations, created a shared strategic vision and established governance structures. However, the engagement of clinicians was variable and there was no evidence to date of significant reductions in emergency admissions. There was some evidence of changes in care processes. Conclusion Although the pilot has demonstrated the beginnings of large-scale change, it remains in the early stages and faces significant challenges as it seeks to become sustainable for the longer term. It is critical that National Health Service managers and clinicians have realistic expectations of what can be achieved in a relatively short period of time. PMID:24167455

  4. Resilience of Self-Organised and Top-Down Planned Cities—A Case Study on London and Beijing Street Networks

    PubMed Central

    Wang, Jiaqiu

    2015-01-01

    The success or failure of the street network depends on its reliability. In this article, using resilience analysis, the author studies how the shape and appearance of street networks in self-organised and top-down planned cities influences urban transport. Considering London and Beijing as proxies for self-organised and top-down planned cities, the structural properties of London and Beijing networks first are investigated based on their primal and dual representations of planar graphs. The robustness of street networks then is evaluated in primal space and dual space by deactivating road links under random and intentional attack scenarios. The results show that the reliability of London street network differs from that of Beijing, which seems to rely more on its architecture and connectivity. It is found that top-down planned Beijing with its higher average degree in the dual space and assortativity in the primal space is more robust than self-organised London using the measures of maximum and second largest cluster size and network efficiency. The article offers an insight, from a network perspective, into the reliability of street patterns in self-organised and top-down planned city systems. PMID:26682551

  5. Modern Christian healing of mental illness.

    PubMed

    Favazza, A R

    1982-06-01

    Healing of mental illness through religious practices was a key element of early Christianity. In the early twentieth century such healing was associated with blue-collar and rural Fundamentalists, but religious healing practices have gained widespread acceptance by many middle-class, conservative Christian groups. "Evil demons" are now equated with envy, pride, avarice, hatred, and obsessions with alcohol and gambling. Many psychotherapeutic techniques of modern Christian healers appear to be rediscoveries of psychoanalytic insights expressed in religious metaphors. Most responsible healers encourage clients to seek medical and psychiatric help, especially for serious mental disorders. Psychiatrists need not share patients' religious beliefs, but for treatment to be effective these beliefs must be understood and respected.

  6. Adaptation and Validation of the Tower of London Test of Planning and Problem Solving in People with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Masson, J. D.; Dagnan, D.; Evans, J.

    2010-01-01

    Background: There is a need for validated, standardised tools for the assessment of executive functions in adults with intellectual disabilities (ID). This study examines the validity of a test of planning and problem solving (Tower of London) with adults with ID. Method: Participants completed an adapted version of the Tower of London (ToL) while…

  7. A fatal case of Lassa fever in London, January 2009.

    PubMed

    Kitching, A; Addiman, S; Cathcart, S; Bischop, L; Krahé, D; Nicholas, M; Coakley, J; Lloyd, G; Brooks, T; Morgan, D; Turbitt, D

    2009-02-12

    In January 2009, the eleventh [corrected] case of Lassa fever imported to the United Kingdom was diagnosed in London. Risk assessment of 328 healthcare contacts with potential direct exposure to Lassa virus - through contact with the case or exposure to bodily fluids - was undertaken. No contacts were assessed to be at high risk of infection and no secondary clinical cases identified.

  8. Alternative Educational Provision in an Area of Deprivation in London

    ERIC Educational Resources Information Center

    Cajic-Seigneur, Magdalena; Hodgson, Ann

    2016-01-01

    The attainment in national examinations and progress of pupils to the age of 16 in London is the highest in England. Nevertheless, there is still a significant number of 16- to 19-year-olds who are not in employment, education, or training (NEET). Those who are the most vulnerable to becoming NEET are the young people who have disengaged from…

  9. Martha Whiteley of Imperial College, London: A Pioneering Woman Chemist

    ERIC Educational Resources Information Center

    Nicholson, Rafaelle M.; Nicholson, John W.

    2012-01-01

    Martha Whiteley (1866-1956) was one of the most important women chemists in the United Kingdom in the first half of the 20th century. In a male-dominated field, she was an academic on the staff of a co-educational university, Imperial College, London, where she carried out research of her own choosing, rather than assisting a male professor. She…

  10. Bacterial contamination on touch surfaces in the public transport system and in public areas of a hospital in London.

    PubMed

    Otter, J A; French, G L

    2009-12-01

    To investigate bacterial contamination on hand-touch surfaces in the public transport system and in public areas of a hospital in central London. Dipslides were used to sample 118 hand-touch surfaces in buses, trains, stations, hotels and public areas of a hospital in central London. Total aerobic counts were determined, and Staphylococcus aureus isolates were identified and characterized. Bacteria were cultured from 112 (95%) of sites at a median concentration of 12 CFU cm(-2). Methicillin-susceptible Staph. aureus (MSSA) was cultured from nine (8%) of sites; no sites grew methicillin-resistant Staph. aureus (MRSA). Hand-touch sites in London are frequently contaminated with bacteria and can harbour MSSA, but none of the sites tested were contaminated with MRSA. Hand-touch sites can become contaminated with staphylococci and may be fomites for the transmission of bacteria between humans. Such sites could provide a reservoir for community-associated MRSA (CA-MRSA) in high prevalence areas but were not present in London, a geographical area with a low incidence of CA-MRSA.

  11. "Walking and watching" in queer London: Sarah Waters' Tipping The Velvet and The Night Watch.

    PubMed

    Wood, Rachel

    2013-01-01

    This article argues that Sarah Waters' representation of London in her historical fictions Tipping the Velvet and The Night Watch is used to delineate the gendered bodies and sexual identities of her characters. A historical summary demonstrates that female masculinity was slowly mapped onto sexual identity between the 1880s and 1940s in Britain. The article argues that Waters' "inventive" use of this history allows her to question the construction of both historical and contemporary identifications. The way that Waters' characters are constricted and liberated by London's urban landscape demonstrates the spatial and temporal contingency of both gender and sexuality.

  12. Complementary Schools in Action: Networking for Language Development in East London

    ERIC Educational Resources Information Center

    Sneddon, Raymonde

    2014-01-01

    In a challenging economic and political context, complementary schools in East London are mentoring each other and forming networks across communities to gain recognition and status for community languages in education and the wider community. As issues of power and status impact in different ways on differently situated communities, complementary…

  13. Symbolic Boundaries and School Structure in New York and London Schools

    ERIC Educational Resources Information Center

    Warikoo, Natasha Kumar

    2010-01-01

    This article shows that an ethnically diverse student population leads to blurred ethnic and racial boundaries in high schools. Still, students in New York distinguish themselves much more along ethnic and racial lines than do London students. The evidence presented suggests that, in addition to national-level differences, traditional British…

  14. Trends in use of electroconvulsive therapy in South London from 1949 to 2006.

    PubMed

    Lambe, Sinéad; Mogg, Andrew; Eranti, Savitha; Pluck, Graham; Hastilow, Sarah; McLoughlin, Declan M

    2014-12-01

    Electroconvulsive therapy (ECT) remains the most acutely effective treatment for severe depression, but its use has declined since its introduction more than 70 years ago. To provide some historical perspective on changes in ECT practice, the objective of the present study was to identify trends in ECT practice in selected teaching hospitals in South London, UK, between 1949 and 2006. Annual rates of ECT for 1949-1970 were estimated from the contemporary hospital reports of the Maudsley and Bethlem Royal hospitals in South London, UK. Case notes were also retrospectively reviewed to calculate annual rates of ECT administration and extract demographic and clinical information for approximately every 5 years between 1987 and 2006. The annual rate of ECT peaked at 35% of total admission in 1956 and declined gradually thereafter to 10.8% by 1970 and fell below 2.2% from 1991 onward. Depressed and female patients were more likely to receive ECT. Compared to previous years, patients were more severely ill and treatment resistant in 2006, whereas ethnic minorities made up 30% of patients receiving ECT compared to approximately 14% in the preceding years. Currently, ECT seems to be provided increasingly late in more severe illness episodes. The ethnicity of patients receiving ECT in South London may be becoming more representative of the background population, but ECT is being used relatively more frequently for nonaffective disorders in ethnic minorities.

  15. ‘Elderly years cause a Total dispaire of Conception’: Old Age, Sex and Infertility in Early Modern England

    PubMed Central

    Toulalan, Sarah

    2016-01-01

    Abstract Although the history of old age has been studied in much greater detail in recent years, the subject of sexuality in old age remains relatively under-explored. This article examines early modern ideas about old bodies and sex in relation to fertility, to argue that because old bodies were understood as either infertile (post-menopausal women) or sub-fertile (old men) they were therefore characterised as unsuitable, undesirable and inappropriate sexual partners. Perceptions of old bodies, their sexual abilities, desirability and behaviour were remarkably consistent from the sixteenth through to the eighteenth century. The ridiculing of old men and women's sexual behaviour that permeated contemporary culture in stories, ballads and jokes, alongside medical literature that characterised old bodies as sexually unappetising as well as unreproductive, carried the message that sexual activity was not for the old, and in large part because they were infertile. PMID:28751815

  16. Desensitisation to cigarette package graphic health warnings: a cohort comparison between London and Singapore.

    PubMed

    Ratneswaran, Culadeeban; Chisnall, Ben; Li, Mingyue; Tan, Sarah; Douiri, Abdel; Anantham, Devanand; Steier, Joerg

    2016-10-24

    We compared 2 sociocultural cohorts with different duration of exposure to graphic health warning labels (GHWL), to investigate a possible desensitisation to their use. We further studied how a differing awareness and emotional impact of smoking-associated risks could be used to prevent this. Structured interviews of patients from the general respiratory department were undertaken between 2012 and 2013 in 2 tertiary hospitals in Singapore and London. 266 participants were studied, 163 Londoners (35% smokers, 54% male, age 52±18 years) and 103 Singaporeans (53% smokers, p=0.003; 78% male, p<0.001; age 58±15 years, p=0.012). 50 items assessed demographics, smoking history, knowledge and the deterring impact of smoking-associated risks. After showing 10 GHWL, the impact on emotional response, cognitive processing and intended smoking behaviour was recorded. Singaporeans scored lower than the Londoners across all label processing constructs, and this was consistent for the smoking and non-smoking groups. Londoners experienced more 'disgust' and felt GHWL were more effective at preventing initiation of, or quitting, smoking. Singaporeans had a lower awareness of lung cancer (82% vs 96%, p<0.001), despite ranking it as the most deterring consequence of smoking. Overall, 'blindness' was the least known potential risk (28%), despite being ranked as more deterring than 'stroke' and 'oral cancer' in all participants. The length of exposure to GHWL impacts on the effectiveness. However, acknowledging the different levels of awareness and emotional impact of smoking-associated risks within different sociocultural cohorts could be used to maintain their impact. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  17. The space laboratory of University College London

    NASA Astrophysics Data System (ADS)

    Johnstone, Alan

    1994-10-01

    University College London was one of the first universities in the world to become involved in making scientific observations in space. Since its laboratory, the Mullard Space Science Laboratory was established, it has participated in 40 satellite missions and more than 200 sounding rocket experiments. Its scientific research in five fields, space plasma physics, high energy astronomy, solar astronomy, Earth remote sensing, and detector physics is internationally renowned. The scientific and technological expertise development through the construction and use of space instrumentation has been fed back into an educational program which leads to degrees at the three levels of B.Sc., M.Sc., and Ph.D.

  18. [Development of modern medical doctors in Japan from late Edo to early Meiji].

    PubMed

    Kim, OckJoo; Takuya, Miyagawa

    2011-12-31

    Western medicine began to be introduced to Japan since late 16th century. Japanese encounter with Western medicine centered on Dejima in Nagasaki in the seventeenth and eighteenth century and the initial process of introduction was gradual and slow. In the mid-nineteenth century, facing threats from Western countries, Tokugawa bakufu asked Dutch naval surgeon, J. L. C. Pompe van Meerdervoort to teach western medicine at the Kaigun Denshujo naval academy in Nagasaki. The government also supported the western medical school in Edo. This paper deals with how modern western medical doctors were developed in Japan from late Edo to early Meiji. The publication of the New Text on Anatomy in 1774 translated by Sugita Genpaku and his colleagues stimulated Japanese doctors and scholars to study western medicine, called Rangaku. During the Edo period, western medicine spread into major cities and countryside in Japan through Rangaku doctors. In 1838, for example, Dr. Ogata Koan established the Rangaku school named Tekijuku and educated many people with western medicine. When smallpox vaccination was introduced in Japan in 1849, Rangaku doctors played an important role in practiving the vaccination in cities and in countryside. After the Edo bakufu and the feudal lords of han(han) actively pursued to introduce western medicine to their hans by sending their Samurai to Edo or Nagasaki or abroad and by establishing medical schools and hospitals until their abolition in 1871. In late Edo and early Meiii military doctors were the main focus of training to meet the urgent need of military doctors in the battle fields of civil wars. The new Meiji government initiated a series of top-down reformations concerning army recruitment, national school system, public health and medical system. In 1874, the government introduced a law on medicine to adopt western medicine only and to launch a national licence system for medical doctors. Issuing supplementary regulations in the following

  19. Using a Group Approach to Preventing Heroin Overdose in North London

    ERIC Educational Resources Information Center

    Phillips, Peter; Glover, Chris; Allan, Teresa; Khoo, Mary Ellen

    2009-01-01

    Aims: This study used group psycho-education methods to assist injecting heroin users in preventing, and responding to overdose. Methods: An "OD Prevention" group was advertised in a London prescribing service and associated primary care unit. The intervention took place in a small group over one afternoon (3.5 hours), and trained…

  20. The gatekeepers of modern physics: periodicals and peer review in 1920s Britain.

    PubMed

    Clarke, Imogen

    2015-03-01

    This essay analyzes the processes behind the publication of physics papers in two British journals in the 1920s: the Proceedings of the Royal Society of London: Series A and the Philosophical Magazine. On the surface, it looked as though the Philosophical Magazine was managed very informally, while the Proceedings had in place a seemingly rigid system of committee approval and peer review. This essay shows, however, that in practice the two journals were both influenced by networks of expertise that afforded small groups of physicists considerable control over the content of these prestigious scientific publications. This study explores the nature of peer review, suggesting how a historical approach can contribute to contemporary debates. In studying these relationships, the essay also considers the interplay of "classical" and "modern" ideas and physicists in 1920s Britain and cautions against an anachronistic approach to this classification.

  1. Some reminiscences about my early career

    NASA Astrophysics Data System (ADS)

    Domb, Cyril

    1990-09-01

    The author recalls some of the highlights of his scientific career before he took up a professional appointment at King's College, London in 1954. The periods covered are: High School and undergraduate studies at Cambridge University 1932-1941; radar research for the British Admiralty 1941-1946; graduate studies at Cambridge University 1946-1949; post-doctoral research at the Clarendon Laboratory, Oxford University 1949-1952; faculty appointment at Cambridge University 1952-1954. A brief description is given of the personalities with whom the author was associated, the research problems in which he was involved, and of the early post world war 2 scientific conferences.

  2. Food Projects in London: Lessons for Policy and Practice--A Hidden Sector and the Need for "More Unhealthy Puddings ... Sometimes"

    ERIC Educational Resources Information Center

    Caraher, Martin; Dowler, Elizabeth

    2007-01-01

    Background and Objective: Successive governments have promoted local action to address food components of public health. This article presents findings from research commissioned by the (then) London NHS Office, scoping the range of food projects in the London area, and the potential challenges to public health practice. Methods: Research followed…

  3. Assessing support for supervised injection services among community stakeholders in London, Canada.

    PubMed

    Bardwell, Geoff; Scheim, Ayden; Mitra, Sanjana; Kerr, Thomas

    2017-10-01

    Few qualitative studies have examined support for supervised injection services (SIS), and these have been restricted to large cities. This study aimed to assess support for SIS among a diverse representation of community stakeholders in London, a mid-sized city in southwestern Ontario, Canada. This qualitative study was undertaken as part of the Ontario Integrated Supervised Injection Services Feasibility Study. We used purposive sampling methods to recruit a diversity of key informants (n=20) from five sectors: healthcare; social services; government and municipal services; police and emergency services; and the business and community sector. Interview data, collected via one-to-one semi structured interviews, were coded and analyzed using thematic analyses through NVivo 10 software. Interview participants unanimously supported the implementation of SIS in London. However, participant support for SIS was met with some implementation-related preferences and/or conditions. These included centralization or decentralization of SIS; accessibility of SIS for people who inject drugs; proximity of SIS to interview participants; and other services and strategies offered alongside SIS. The results of this study challenge the assumptions that smaller cities like London may be unlikely to support SIS. Community stakeholders were supportive of the implementation of SIS with some preferences or conditions. Interview participants had differing perspectives, but ultimately supported similar end goals of accessibility and reducing community harms associated with injection drug use. Future research and SIS programming should consider these factors when determining optimal service delivery in ways that increase support from a diversity of community stakeholders. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Publishing the works of Nicholas Culpeper, astrological herbalist and translator of Latin medical works in seventeenth-century London.

    PubMed

    McCarl, M R

    1996-01-01

    This investigation attempts primarily to untangle the complex publishing history of the works of Nicholas Culpeper (1616-54), astrological herbalist and translator of Latin medical works. It therefore identifies those works published in seventeenth-century London: the study indicates that London stationers capitalized on the reputation of Nicholas Culpeper to build the widest possible market for his original astrological/herbal medical works and his translations from continental authors.

  5. Evidence for a genetic discontinuity between Neandertals and 24,000-year-old anatomically modern Europeans.

    PubMed

    Caramelli, David; Lalueza-Fox, Carles; Vernesi, Cristiano; Lari, Martina; Casoli, Antonella; Mallegni, Francesco; Chiarelli, Brunetto; Dupanloup, Isabelle; Bertranpetit, Jaume; Barbujani, Guido; Bertorelle, Giorgio

    2003-05-27

    During the late Pleistocene, early anatomically modern humans coexisted in Europe with the anatomically archaic Neandertals for some thousand years. Under the recent variants of the multiregional model of human evolution, modern and archaic forms were different but related populations within a single evolving species, and both have contributed to the gene pool of current humans. Conversely, the Out-of-Africa model considers the transition between Neandertals and anatomically modern humans as the result of a demographic replacement, and hence it predicts a genetic discontinuity between them. Following the most stringent current standards for validation of ancient DNA sequences, we typed the mtDNA hypervariable region I of two anatomically modern Homo sapiens sapiens individuals of the Cro-Magnon type dated at about 23 and 25 thousand years ago. Here we show that the mtDNAs of these individuals fall well within the range of variation of today's humans, but differ sharply from the available sequences of the chronologically closer Neandertals. This discontinuity is difficult to reconcile with the hypothesis that both Neandertals and early anatomically modern humans contributed to the current European gene pool.

  6. Volatile organic compound fluxes and concentrations in London (ClearfLo)

    NASA Astrophysics Data System (ADS)

    Valach, Amy; Langford, Ben; Nemitz, Eiko; MacKenzie, Rob; Hewitt, Nick

    2014-05-01

    Volatile organic compounds (VOCs) from anthropogenic sources such as fuel combustion or evaporative emissions can directly and indirectly affect human health. Some VOCs, such as benzene and 1,3- butadiene are carcinogens. These and other VOCs contribute to the formation of ozone (O3) and aerosol particles, which have effects on human health and the radiative balance of the atmosphere. Although in the UK VOC emissions are subject to control under European Commission Directive 2008/50/EC and emission reducing technologies have been implemented, urban air pollution remains a concern. Urban air quality is likely to remain a priority since currently >50% of the global population live in urban areas with trends in urbanization and population migration predicted to increase. The ClearfLo project is a large multi-institutional consortium funded by the UK Natural Environment Research Council (NERC) and provides integrated measurements of meteorology, gas phase and particulate composition of the atmosphere over London. Both long term and IOP measurements were made at street and elevated locations at a range of sites across London and its surroundings during 2011 and 2012. Mixing ratios of a selection of nine VOCs were measured using a high sensitivity proton transfer reaction-mass spectrometer (PTR-MS) at a ground level urban background (North Kensington) and kerbside (Marylebone Road) site during the winter IOP. VOC fluxes were measured by virtually disjunct eddy covariance (vDEC) at an elevated urban site (King's College Strand) in Aug-Dec 2012. Our results for the first IOP showed that most of the selected compound concentrations depended on traffic emissions, although there was a marked difference between the urban background and kerbside sites. We identified some temperature effects on VOC concentrations. We also present the first analyses of VOC flux measurements over London. Preliminary analyses indicate most compounds associated with vehicle emissions closely

  7. Teaching the Very Recent Past: "Miriam's Vision" and the London Bombings

    ERIC Educational Resources Information Center

    Kitson, Alison; Thompson, Sarah

    2015-01-01

    "Miriam's Vision" is an educational project developed by the Miriam Hyman Memorial Trust, an organisation set up in memory of Miriam Hyman, one of the 52 victims of the London bombings of 2005. The project has developed a number of subject-based modules, including history, which are provided free to schools through the website…

  8. Carbon dioxide and methane emission dynamics in central London (UK)

    NASA Astrophysics Data System (ADS)

    Helfter, Carole; Nemitz, Eiko; Barlow, Janet F.; Wood, Curtis R.

    2013-04-01

    London, with a population of 8.2 million, is the largest city in Europe. It is heavily built-up (typically 8% vegetation cover within the central boroughs) and boasts some of the busiest arteries in Europe despite efforts to reduce traffic in the city centre with the introduction of a congestion charging scheme in 2007. We report on two substantial pollution monitoring efforts in the heart of London between October 2006 and present. Fluxes of carbon dioxide (CO2) and water (H2O) were measured continuously by eddy-covariance in central London from October 2006 until May 2008 from a 190 m telecommunication tower (BT tower; 51° 31' 17.4'' N 0° 8' 20.04'' W). The eddy-covariance system consisted of a Gill R3-50 ultrasonic anemometer operated at 20 Hz and a LI-COR 6262 infrared gas analyser. Air was sampled 0.3 m below the sensor head of the ultrasonic anemometer - which was itself mounted on a 3 m mast to the top of a 15 m lattice tower situated on the roof of the tower (instrument head at 190 m above street level) - and pulled down 45 m of 12.7 mm OD Teflon tubing. In addition, meteorological variables (temperature, relative humidity, pressure, precipitation, wind speed and direction) were also measured with a multi-sensor (Weather Transmitter WXT510, Vaisala). Eddy-covariance measurements at the BT tower location were reinstated in July 2011 and include methane (CH4), CO2 and H2O concentrations measured by a Picarro fast methane analyser (G2301-f). CO2 emissions were found to be mainly controlled by fossil fuel combustion (e.g. traffic, commercial and domestic heating). Diurnal averages of CO2 fluxes were found to be highly correlated to traffic. However changes in heating-related natural gas consumption and, to a lesser extent, photosynthetic activity in two large city centre green spaces (Hyde Park and Regent's Park) explained the seasonal variability. Annual estimates of net exchange of CO2 obtained by eddy-covariance agreed well with up-scaled data from the UK

  9. On the exchange-hole model of London dispersion forces

    NASA Astrophysics Data System (ADS)

    Ángyán, János G.

    2007-07-01

    First-principles derivation is given for the heuristic exchange-hole model of London dispersion forces by Becke and Johnson [J. Chem. Phys. 122, 154104 (2005)]. A one-term approximation is used for the dynamic charge density response function, and it is shown that a central nonempirical ingredient of the approximate nonexpanded dispersion energy is the charge density autocorrelation function, a two-particle property, related to the exchange-correlation hole. In the framework of a dipolar approximation of the Coulomb interaction around the molecular origin, one obtains the so-called Salem-Tang-Karplus approximation to the C6 dispersion coefficient. Alternatively, by expanding the Coulomb interaction around the center of charge (centroid) of the exchange-correlation hole associated with each point in the molecular volume, a multicenter expansion is obtained around the centroids of electron localization domains, always in terms of the exchange-correlation hole. In order to get a formula analogous to that of Becke and Johnson, which involves the exchange-hole only, further assumptions are needed, related to the difficulties of obtaining the expectation value of a two-electron operator from a single determinant. Thus a connection could be established between the conventional fluctuating charge density model of London dispersion forces and the notion of the "exchange-hole dipole moment" shedding some light on the true nature of the approximations implicit in the Becke-Johnson model.

  10. Impact of natural products in modern drug development.

    PubMed

    Dev, Sukh

    2010-03-01

    Usage of natural substances as therapeutic agents in modern medicine has sharply declined from the predominant position held in the early decades of last century, but search for bioactive molecules from nature (plants, animals, microflora) continues to play an important role in fashioning new medicinal agents. With the advent of modern techniques, instrumentation and automation in isolation and structural characterisation, we have on hand an enormous repository of natural compounds. In parallel to this, biology has also made tremendous progress in expanding its frontiers of knowledge. An interplay of these two disciplines constitutes the modern thrust in research in the realm of compounds elaborated by nature. The purpose of this article is to underline how natural products research continues to make significant contributions in the domain of discovery and development of new medicinal products. It is proposed to present the material under several heads, each of which has made natural products research relevant in the search for new and better medication.

  11. On the origin of modern humans: Asian perspectives.

    PubMed

    Bae, Christopher J; Douka, Katerina; Petraglia, Michael D

    2017-12-08

    The traditional "out of Africa" model, which posits a dispersal of modern Homo sapiens across Eurasia as a single wave at ~60,000 years ago and the subsequent replacement of all indigenous populations, is in need of revision. Recent discoveries from archaeology, hominin paleontology, geochronology, genetics, and paleoenvironmental studies have contributed to a better understanding of the Late Pleistocene record in Asia. Important findings highlighted here include growing evidence for multiple dispersals predating 60,000 years ago in regions such as southern and eastern Asia. Modern humans moving into Asia met Neandertals, Denisovans, mid-Pleistocene Homo , and possibly H. floresiensis , with some degree of interbreeding occurring. These early human dispersals, which left at least some genetic traces in modern populations, indicate that later replacements were not wholesale. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  12. "It's Just More in the Real World Really": How Can a Local Project Support Early Years Practitioners from Different Settings in Working and Learning Together?

    ERIC Educational Resources Information Center

    Cotton, Lizzie

    2013-01-01

    This article describes how early years practitioners working in different settings, with different experiences and qualifications, can work and learn together. It is a small-scale case study of an eight-month project, with a grass-roots approach, involving early years settings within the reach area of an inner-London Children's Centre. The data…

  13. 75 FR 20776 - Drawbridge Operation Regulations; Shaw Cove, New London, CT, Maintenance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 [Docket No. USCG-2010-0227] Drawbridge Operation Regulations; Shaw Cove, New London, CT, Maintenance AGENCY: Coast Guard, DHS. ACTION: Notice of... temporary deviation from the regulation governing the operation of the Amtrak Bridge across Shaw Cove, mile...

  14. THE IMPACT OF THE CONGESTION CHARGING SCHEME ON AIR QUALITY IN LONDON

    EPA Science Inventory

    The modeling studies predicted small changes in both emissions and ambient concentrations of NOx, NO2, and PM10 across London that could be related to the implementation of the CCS, although the effects within the CCZ were projected to be more pronounced than elsewhere. The...

  15. Maternal, fetal, and placental conditions associated with medically indicated late preterm and early term delivery: a retrospective study.

    PubMed

    Brown, H K; Speechley, K N; Macnab, J; Natale, R; Campbell, M K

    2016-04-01

    Our objectives were: (1) to examine the association between maternal, fetal, and placental phenotypes of preterm delivery and medically indicated early delivery of singletons during the late preterm and early term periods; and (2) to identify the specific maternal, fetal, and placental conditions associated with these early deliveries. Retrospective study. City of London and Middlesex County, Ontario, Canada. Singleton live deliveries, at 34-41 weeks of gestation to women in London and Middlesex. We obtained data from a city-wide perinatal database (2002-2011; n = 25 699). We used multinomial logistic regression for multivariable analyses. The outcome was the occurrence of medically indicated late preterm (34-36 weeks of gestation) and early term (37-38 weeks of gestation) delivery, versus delivery at full term (39-41 weeks of gestation). After controlling for confounding factors, all phenotypes were associated with increased odds of medically indicated late preterm and early term delivery. Within the maternal phenotype, chronic maternal medical conditions were associated with increased odds of medically indicated early term delivery (e.g. for gastrointestinal disease, adjusted odds ratio, aOR 1.72, 95% CI 1.47-2.00; for anaemia, aOR 1.40, 95% CI 1.20-1.63), but not late preterm delivery. The aetiology of medically indicated early delivery close to full term is heterogeneous. Patterns of associations suggest slightly different conditions underlying the late preterm and early term phenotypes, with chronic maternal medical conditions being associated with early term delivery but not with late preterm delivery. These results have implications for the prevention of early delivery as well as the identification of high-risk groups among those born early. The aetiology of medically indicated late preterm and early term delivery is heterogeneous. © 2015 Royal College of Obstetricians and Gynaecologists.

  16. [Drug trials in humans. Risks in the light of the London catastrophe].

    PubMed

    Otte, A

    2007-06-01

    London's first-in-man drug trial with the monoclonal anti-CD28 antibody TGN1412 used for the treatment of oncological and autoimmune diseases resulted in a disaster with life-threatening adverse events in the volunteers triggered by an unexpected cytokine storm. Potential mistakes and consequences from this trial are highlighted in the general context of drug development and its risks. Risks in drug testing are not only found for high risk substances, such as TGN1412, or in the critical first-in-man phase, but can sometimes be detected only in later phases of the clinical testing, such as the phase 3 submission studies, or even after market authorization, as for example was the case in the cyclooxygenase-2-inhibitor rofecoxib (Vioxx) used for the treatment of rheumatic diseases and acute pain. Regulatory requirements to minimize risks in drug trials, however, have improved substantially over the last decades. Moreover, in light of the London incident these are being continuously modified with great diligence.

  17. Measures of maturation in early fossil hominins: events at the first transition from australopiths to early Homo

    PubMed Central

    Dean, M. Christopher

    2016-01-01

    An important question in palaeoanthropology is whether, among the australopiths and the first fossil hominins attributed to early Homo, there was a shift towards a more prolonged period of growth that can be distinguished from that of the living great apes and whether between the end of weaning and the beginning of puberty there was a slow period of growth as there is in modern humans. Evidence for the pace of growth in early fossil hominins comes from preserved tooth microstructure. A record of incremental growth in enamel and dentine persists, which allows us to reconstruct tooth growth and compare key measures of dental maturation with modern humans and living great apes. Despite their diverse diets and way of life, it is currently difficult to identify any clear differences in the timing of dental development among living great apes, australopiths and the earliest hominins attributed to the genus Homo. There is, however, limited evidence that some early hominins may have attained a greater proportion of their body mass and stature relatively earlier in the growth period than is typical of modern humans today. This article is part of the themed issue ‘Major transitions in human evolution’. PMID:27298465

  18. ‘Islamic fatalism’: life and suffering among Bangladeshi psychiatric patients and their families in London – an interview study 2

    PubMed Central

    Littlewood, Roland; Dein, Simon

    2013-01-01

    An interview study of 44 Bangladeshi patients and relatives in eastern London demonstrated frequent appeals to God and deprecation of personal agency. This paper offers an interpretation of this apparent ‘fatalism’, which argues for the logical downplaying of human agency and ambition in archaic Arabia, contemporary rural Sylhet and among first generation Sylheti migrants in London. PMID:24670160

  19. Analog "neuronal" networks in early vision.

    PubMed Central

    Koch, C; Marroquin, J; Yuille, A

    1986-01-01

    Many problems in early vision can be formulated in terms of minimizing a cost function. Examples are shape from shading, edge detection, motion analysis, structure from motion, and surface interpolation. As shown by Poggio and Koch [Poggio, T. & Koch, C. (1985) Proc. R. Soc. London, Ser. B 226, 303-323], quadratic variational problems, an important subset of early vision tasks, can be "solved" by linear, analog electrical, or chemical networks. However, in the presence of discontinuities, the cost function is nonquadratic, raising the question of designing efficient algorithms for computing the optimal solution. Recently, Hopfield and Tank [Hopfield, J. J. & Tank, D. W. (1985) Biol. Cybern. 52, 141-152] have shown that networks of nonlinear analog "neurons" can be effective in computing the solution of optimization problems. We show how these networks can be generalized to solve the nonconvex energy functionals of early vision. We illustrate this approach by implementing a specific analog network, solving the problem of reconstructing a smooth surface from sparse data while preserving its discontinuities. These results suggest a novel computational strategy for solving early vision problems in both biological and real-time artificial vision systems. PMID:3459172

  20. The Hidden History of a Famous Drug: Tracing the Medical and Public Acculturation of Peruvian Bark in Early Modern Western Europe (c. 1650-1720).

    PubMed

    Klein, Wouter; Pieters, Toine

    2016-10-01

    The history of the introduction of exotic therapeutic drugs in early modern Europe is usually rife with legend and obscurity and Peruvian bark is a case in point. The famous antimalarial drug entered the European medical market around 1640, yet it took decades before the bark was firmly established in pharmaceutical practice. This article argues that the history of Peruvian bark can only be understood as the interplay of its trajectories in science, commerce, and society. Modern research has mostly focused on the first of these, largely due to the abundance of medico-historical data. While appreciating these findings, this article proposes to integrate the medical trajectory in a richer narrative, by drawing particular attention to the acculturation of the bark in commerce and society. Although the evidence we have for these two trajectories is still sketchy and disproportionate, it can nevertheless help us to make sense of sources that have not yet been an obvious focus of research. Starting from an apparently isolated occurrence of the drug in a letter, this article focuses on Paris as the location where medical and public appreciation of the bark took shape, by exploring several contexts of knowledge circulation and medical practice there. These contexts provide a new window on the early circulation of knowledge of the bark, at a time when its eventual acceptance was by no means certain. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  1. Survival Analysis Of The Modernized Retirement System For The United States Marine Corps

    DTIC Science & Technology

    2016-03-01

    November 2015 to begin as early as 2018. This online survey will assist the Marine Corps in determining the retention impacts of the new retirement...thesis determines if the Modernized Retirement System is likely to affect manpower levels. A survey was conducted within the active component of the U.S...2016. Specifically, this thesis determines if the Modernized Retirement System is likely to affect manpower levels. A survey was conducted within

  2. Healthcare Planning for the Olympics in London: A Qualitative Evaluation

    PubMed Central

    Black, Georgia; Kononovas, Kostas; Taylor, Jayne; Raine, Rosalind

    2014-01-01

    Background Mass gatherings, such as the Olympic and Paralympic Games, represent an enormous logistical challenge for the host city. Health service planners must deliver routine and emergency services and, in recent Games, health legacy initiatives, for the local and visiting population. However there is little evidence to support their planning decisions. We therefore evaluated the strategic health planning programme for the London 2012 Olympic and Paralympic Games to identify generalisable information for future Games. Methods We thematically analysed data from stakeholder interviews and documents. The data were prospectively collected in three phases, before, during and after the Games. Findings We identified five key themes: (1) Systemic Improvement for example in communications, (2) Effective relationships led to efficiencies and permanent gains, such as new relationships with the private sector (3) Difficult relationships led to inefficiencies, for instance, duplication in testing and exercising emergency scenarios, (4) Tendency to over-estimate demand for care, particularly emergency medicine, and (5) Difficulties establishing a health legacy due to its deprioritisation and lack of vision by the programme team. Interpretation Enduring improvements which are sustained after the Games are possible, such as the establishment of new and productive partnerships. Relationships must be established early on to avoid duplication, delay and unnecessary expense. There should be greater critical evaluation of the likely demand for health services to reduce the wasting of resources. Finally, if a health legacy is planned, then clear definitions and commitment to its measurement is essential. PMID:24647613

  3. Healthcare planning for the Olympics in London: a qualitative evaluation.

    PubMed

    Black, Georgia; Kononovas, Kostas; Taylor, Jayne; Raine, Rosalind

    2014-01-01

    Mass gatherings, such as the Olympic and Paralympic Games, represent an enormous logistical challenge for the host city. Health service planners must deliver routine and emergency services and, in recent Games, health legacy initiatives, for the local and visiting population. However there is little evidence to support their planning decisions. We therefore evaluated the strategic health planning programme for the London 2012 Olympic and Paralympic Games to identify generalisable information for future Games. We thematically analysed data from stakeholder interviews and documents. The data were prospectively collected in three phases, before, during and after the Games. We identified five key themes: (1) Systemic Improvement for example in communications, (2) Effective relationships led to efficiencies and permanent gains, such as new relationships with the private sector (3) Difficult relationships led to inefficiencies, for instance, duplication in testing and exercising emergency scenarios, (4) Tendency to over-estimate demand for care, particularly emergency medicine, and (5) Difficulties establishing a health legacy due to its deprioritisation and lack of vision by the programme team. Enduring improvements which are sustained after the Games are possible, such as the establishment of new and productive partnerships. Relationships must be established early on to avoid duplication, delay and unnecessary expense. There should be greater critical evaluation of the likely demand for health services to reduce the wasting of resources. Finally, if a health legacy is planned, then clear definitions and commitment to its measurement is essential.

  4. The modern human colonization of western Eurasia: when and where?

    NASA Astrophysics Data System (ADS)

    Hublin, Jean-Jacques

    2015-06-01

    Dating the timing of the replacement of local Neandertal populations by modern humans in western Eurasia at the dawn of the Upper Palaeolithic remains challenging due to the scarcity of the palaeontological evidence and to the complexity of the archaeological record. Furthermore, key specimens have been discovered in the course of excavations that unfortunately did not meet today's archaeological standards. The importance of site-formation processes in the considered time period makes it sometimes difficult to precisely assign fragmentary remains a posteriori to distinct techno-complexes. The improvements in dating methods have however allowed for the clarification of many chronological issues in the past decade. Archaeological and palaeontological evidence strongly suggest that the initial modern colonization of eastern Europe and central Asia should be related to the spread of techno-complexes assigned to the Initial Upper Palaeolithic. This first expansion may have started as early as 48 ka cal BP. The earliest phases of the Aurignacian complex (Protoaurignacian and Early Aurignacian) seem to represent another modern wave of migrations, starting in the Levant area. The expansion of this techno-complex throughout Europe completed the modern colonization of the continent. The interpretation of a third group of industries referred to as "transitional assemblages" in western and central Europe is much debated. At least in part, these assemblages might have been produced by Neandertal groups that may have survived until c. 41 ka cal BP, according to the directly dated Neandertal specimens of Saint-Césaire (France) and Spy (Belgium).

  5. Morale and job perception of community mental health professionals in Berlin and London.

    PubMed

    Priebe, Stefan; Fakhoury, Walid K H; Hoffmann, Karin; Powell, Richard A

    2005-03-01

    Morale and job perception of staff in community mental health care may influence feasibility and quality of care, and some research has suggested particularly high burnout of staff in the community. The aims of this study were to: a) assess morale, i. e. team identity, job satisfaction and burnout, in psychiatrists, community psychiatric nurses and social workers in community mental health care in Berlin and London; b) compare findings between the groups and test whether personal characteristics, place of working and professional group predict morale; and c) explore what tasks, obstacles, skills, enjoyable and stressful aspects interviewees perceived as important in their jobs. In all, 189 mental health professionals (a minimum of 30 in each of the six groups) responded to a postal survey and reported activities per week using pre-formed categories. Perception of professional role was assessed on the Team Identity Scale, job satisfaction on the Minnesota Job Satisfaction Scale, and burnout on the Maslach Burnout Inventory. Seven simple open questions were used to elicit the main tasks, skills that staff did and did not feel competent in, aspects that they did and did not enjoy in their job, and obstacles and factors that caused pressure. Answers were subjected to content analysis using a posteriori formed categories. Weekly activities and morale varied between sites and professional groups. Some mean scores for groups in London exceeded the threshold for a burnout syndrome, and are particularly less favourable for social workers. Working in London predicted higher burnout, lower job satisfaction and lower team identity. Being a psychiatrist predicted higher team identity, whilst being a social worker was associated with higher burnout and lower job satisfaction. Male gender predicted lower burnout and higher team identity. However, professional group and site interacted in predicting burnout and job satisfaction. Psychiatrists in London had much more favourable

  6. Oral cancer awareness in young South-Asian communities in London.

    PubMed

    Merchant, R; Gallagher, J E; Scott, S E

    2016-03-01

    First, to evaluate awareness of oral cancer amongst the young South-Asian community in London and identify any aspects of knowledge about oral cancer that are lacking; and, second, to determine whether demographic factors or health-related behaviours are associated with knowledge of oral cancer. Cross-sectional questionnaire survey. South Asians aged 18-44 years attending community centres or places of worship in London. Oral cancer awareness; health-related behaviours. Respondents (n = 201) were mainly male (61%), Indian (77%) and Hindu (35%). Over half (58%; n = 113) had one or more negative health-related behaviours and only 18% had attended a dentist in the previous two years. Chewing paan with betel nut (OR = 4.08, 95% CI = 1.58-10.59, p < 0.01), and time since last visit to a dentist (OR = 4.90, 95% CI = 2.13-11.28, p < 0.01) were independently associated with respondents level of knowledge of mouth cancer; the former positively and the latter negatively. The results suggest that young adults in the South Asian Community are exposed to a number of risk factors for oral cancer yet have poor knowledge of the implications of these health-related behaviours, and ways in which oral cancer can be detected earlier. The survey highlighted specific issues for action.

  7. Annotated type catalogue of the Amphibulimidae (Mollusca, Gastropoda, Orthalicoidea) in the Natural History Museum, London

    PubMed Central

    Breure, Abraham S.H.; Ablett, Jonathan D.

    2011-01-01

    Abstract The type status is described of 39 taxa classified within the family Amphibulimidae (superfamily Orthalicoidea) and kept in the London museum. One taxon, Bulimus elaeodes Pfeiffer, 1853, is removed to the Strophocheilidae. Lectotypes are designated for Bulimus adoptus Reeve, 1849; Bulimus (Eurytus) eros Angas, 1878; Helix onca d'Orbigny, 1835; Amphibulima pardalina Guppy, 1868. The type status of the following taxon is changed to lectotype in accordance with Art. 74.6 ICZN: Strophocheilus (Dryptus) jubeus Fulton, 1908. As general introduction to this and following papers on Orthalicoid types in the Natural History Museum, a brief history of the London collection is given and several examples of handwriting from different authors are presented. PMID:22144852

  8. A Virtual Walk through London: Culture Learning through a Cultural Immersion Experience

    ERIC Educational Resources Information Center

    Shih, Ya-Chun

    2015-01-01

    Integrating Google Street View into a three-dimensional virtual environment in which users control personal avatars provides these said users with access to an innovative, interactive, and real-world context for communication and culture learning. We have selected London, a city famous for its rich historical, architectural, and artistic heritage,…

  9. Assessment of HIV Counselling and Social Care Services in a London Hospital.

    ERIC Educational Resources Information Center

    Du Plessis, Peter; And Others

    1995-01-01

    Investigates the use of and satisfaction with counseling and social care services for HIV-infected clients attending HIV specialist clinics at Guy's Hospital and Southwark Social Services, London. A survey of 71 HIV positive clients was carried out using a self-administered questionnaire. Discusses findings and makes recommendations for future…

  10. Evolution of cystic fibrosis lung function in the early years.

    PubMed

    Bush, Andrew; Sly, Peter D

    2015-11-01

    Most treatment of newborn screening-diagnosed cystic fibrosis is not evidence-based; there are very few randomized controlled trials (RCTs). Furthermore, the advent of novel molecular therapies, which could be started at diagnosis, mandates performing RCTs in very young children. However, unless the natural history of early cystic fibrosis lung disease is known, RCTs are impossible. Here, we review the results of two large prospective cohorts of these infants - London Cystic Fibrosis Collaboration (LCFC) (London, UK) and Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST-CF) (Australia). Nutritional status remained excellent in both the cohorts. Both cohorts reported abnormal lung function aged at 3 months. AREST-CF, which previously reported rapidly declining preschool lung function, now report good conventional school-age spirometry. LCFC reported improvement between 3 months and 1 year, and stability in the second year. AREST-CF also reported a high prevalence of high resolution computed tomographic abnormalities related to free neutrophil elastase in bronchoalveolar lavage; LCFC reported high resolution computed tomographic changes at 1 year, which were too mild to be scored reproducibly. At least in the first 2 years of life, lung function is not a good end-point for RCTs; routine bronchoalveolar lavage and HRCT cannot be justified. Newborn screening has greatly improved outcomes, but we need better point-of-care biomarkers.

  11. The North West London Integrated Care Pilot: innovative strategies to improve care coordination for older adults and people with diabetes.

    PubMed

    Harris, Matthew; Greaves, Felix; Patterson, Sue; Jones, Jessica; Pappas, Yannis; Majeed, Azeem; Car, Josip

    2012-01-01

    The North West London Integrated Care Pilot (ICP) was launched in June 2011 and brings together more than 100 general practices, 2 acute care trusts, 5 primary care trusts, 2 mental health care trusts, 3 community health trusts, 5 local authorities, and 2 voluntary sector organizations (Age UK and Diabetes UK) to improve the coordination of care for a pilot population of 550 000 people. Specifically, the ICP serves people older than 75 years and those with diabetes. Although still in the early stages of implementation, the ICP has already received national awards for its innovations in design and delivery. This article critically describes the ICP objectives, facilitating processes, and planned impact as well as the organizational and financial challenges that policy makers are facing in the implementation of the pilot program.

  12. Spatial and temporal associations of road traffic noise and air pollution in London: Implications for epidemiological studies.

    PubMed

    Fecht, Daniela; Hansell, Anna L; Morley, David; Dajnak, David; Vienneau, Danielle; Beevers, Sean; Toledano, Mireille B; Kelly, Frank J; Anderson, H Ross; Gulliver, John

    2016-03-01

    Road traffic gives rise to noise and air pollution exposures, both of which are associated with adverse health effects especially for cardiovascular disease, but mechanisms may differ. Understanding the variability in correlations between these pollutants is essential to understand better their separate and joint effects on human health. We explored associations between modelled noise and air pollutants using different spatial units and area characteristics in London in 2003-2010. We modelled annual average exposures to road traffic noise (LAeq,24h, Lden, LAeq,16h, Lnight) for ~190,000 postcode centroids in London using the UK Calculation of Road Traffic Noise (CRTN) method. We used a dispersion model (KCLurban) to model nitrogen dioxide, nitrogen oxide, ozone, total and the traffic-only component of particulate matter ≤2.5μm and ≤10μm. We analysed noise and air pollution correlations at the postcode level (~50 people), postcodes stratified by London Boroughs (~240,000 people), neighbourhoods (Lower layer Super Output Areas) (~1600 people), 1km grid squares, air pollution tertiles, 50m, 100m and 200m in distance from major roads and by deprivation tertiles. Across all London postcodes, we observed overall moderate correlations between modelled noise and air pollution that were stable over time (Spearman's rho range: |0.34-0.55|). Correlations, however, varied considerably depending on the spatial unit: largest ranges were seen in neighbourhoods and 1km grid squares (both Spearman's rho range: |0.01-0.87|) and was less for Boroughs (Spearman's rho range: |0.21-0.78|). There was little difference in correlations between exposure tertiles, distance from road or deprivation tertiles. Associations between noise and air pollution at the relevant geographical unit of analysis need to be carefully considered in any epidemiological analysis, in particular in complex urban areas. Low correlations near roads, however, suggest that independent effects of road noise and

  13. Measurements of free radicals in a megacity during the Clean Air for London Project

    NASA Astrophysics Data System (ADS)

    Heard, Dwayne; Whalley, Lisa; Stone, Daniel; Clancy, Noel; Lee, James; Kleffman, Jorg; Laufs, Sebastian; Bandy, Brian

    2013-04-01

    Free radicals control the photo-oxidative chemistry of the atmosphere, being responsible for the transformation of primary emissions into secondary pollutants such as NO2, O3, multifunctional species and particulates. Here we present measurements of OH, HO2 and RO2 radicals and OH reactivity recorded at North Kensington, Central London, during two Intensive Operational Periods (IOPs) of the Clear Air for London (Clearflo) project in the summer and winter of 2012. OH and HO2 were measured using laser-induced fluorescence (LIF) spectroscopy at low pressure (the FAGE technique), and RO2 was measured using the recently developed ROXLIF technique, which utilises an external flow-reactor interfaced to FAGE, and which is able to discriminate between HO2 and organic peroxy radicals. Through control of reagent gases we are further able to provide a separate measurement of those RO2 species which are known to give an interference for HO2 measurements (namely alkene, aromatic and large-chain alkane derived RO2). OH reactivity was measured using laser-flash photolysis combined with FAGE. Low concentrations of radicals were observed during the winter IOP, with mixing ratios of [OH] ~ 0.04 pptv, [HO2] ~ 0.4 pptv, and [RO2] ~ 1.6 pptv at noon, all displaying a negative correlation with NO. The photolysis of O3 and subsequent reaction of O(1D) with H2O vapour was only a minor contribution to radical production in winter, with photolysis of HONO a major radical source. The summer IOP coincided with the London Olympic Games, with a number of pollution events, with ozone peaking at 100 ppbv (exceeding EU air quality directives) and elevated radical concentrations (peak [OH] ~ 0.14 pptv, [HO2] ~ 4 pptv, [RO2] ~ 6.4 pptv) being observed. The net rate of ozone production was calculated from radical observations and agreed well with measured ozone production, suggesting that advection/dilution by continental air-masses was not playing a significant role in determining ozone

  14. Developing a new syndromic surveillance system for the London 2012 Olympic and Paralympic Games.

    PubMed

    Harcourt, S E; Fletcher, J; Loveridge, P; Bains, A; Morbey, R; Yeates, A; McCloskey, B; Smyth, B; Ibbotson, S; Smith, G E; Elliot, A J

    2012-12-01

    Syndromic surveillance is vital for monitoring public health during mass gatherings. The London 2012 Olympic and Paralympic Games represents a major challenge to health protection services and community surveillance. In response to this challenge the Health Protection Agency has developed a new syndromic surveillance system that monitors daily general practitioner out-of-hours and unscheduled care attendances. This new national system will fill a gap identified in the existing general practice-based syndromic surveillance systems by providing surveillance capability of general practice activity during evenings/nights, over weekends and public holidays. The system will complement and supplement the existing tele-health phone line, general practitioner and emergency department syndromic surveillance systems. This new national system will contribute to improving public health reassurance, especially to meet the challenges of the London 2012 Olympic and Paralympic Games.

  15. Marketing the municipal model: the London County Council Nursing Service recruitment strategies 1930-45.

    PubMed

    Kirby, S

    1998-01-01

    Municipally administered, with its origins in the Poor Laws, the LCC Nursing Service could be said to have been a Cinderella Service in comparison with the prestigious London voluntary hospitals. This paper analyses the recruitment strategies of the London County Council Nursing Service within the context of the overall national situation during the 1930s and the Second World War. These can be categorised as cosmetic, reactive, innovative and pragmatic. An astute nursing leadership could use the resources of a large municipal authority to challenge the voluntary hospitals in the nursing labour market in the area of acute hospital care. The image of the acute hospitals could be favourably projected; however, local as well as national difficulty persisted in the recruitment of candidates to Cinderella services such as tuberculosis sanatoria.

  16. Parity of access to memory services in London for the BAME population: a cross-sectional study.

    PubMed

    Cook, Laura; Mukherjee, Sujoy; McLachlan, Tim; Shah, Rajendra; Livingston, Gill; Mukadam, Naaheed

    2018-03-12

    To investigate whether referrals to memory services in London reflect the ethnic diversity of the population. Memory service data including referral rates of BAME was collected from London Clinical Commissioning Groups (CCGs). The expected percentage of BAME referrals using census data was compared against White British population percentages using the chi squared test. We found that within 13,166 referrals to memory services across London, the percentage of people from BAME groups was higher than would be expected (20.3 versus 19.4%; χ 2 = 39.203, d.f. = 1, p < 0.0001) indicating that generally people from BAME groups are accessing memory services. Seventy-nine percent of memory services had more referrals than expected or no significant difference for all BAME groups. When there were fewer referrals then expected, the largest difference in percentage for an individual ethnic group was 3.3%. Results are encouraging and may indicate a significant improvement in awareness of dementia and help seeking behaviour among BAME populations. Prevalence of dementia in some ethnic groups may be higher so these numbers could still indicate under-referral. Due to the data available we were unable to compare disease severity or diagnosis type.

  17. How Silent Is the "Silent Period" for Young Bilinguals in Early Years Settings in England?

    ERIC Educational Resources Information Center

    Drury, Rose

    2013-01-01

    During the first decade of the twenty-first century there have been increasing numbers of bilingual children entering early years settings, many of whom are new to English. Twelve percent of school children in the UK are identified as having a mother tongue other than English and this number rises to 50% in urban areas such as inner London. In…

  18. Margaret and Rachel McMillan: Their Influences on Open-Air Nursery Education and Early Years Teacher Education

    ERIC Educational Resources Information Center

    Liebovich, Betty

    2014-01-01

    Rachel and Margaret McMillan created an open-air nursery in Deptford, London that has influenced early years education for 100 years. Their vision for young children living in poverty and deprivation to have access to fresh air through outdoor learning, nutritious meals, and an enriching environment to explore and develop has been embraced and…

  19. Change in Urban Albedo in London: A Multi-scale Perspective

    NASA Astrophysics Data System (ADS)

    Susca, T.; Kotthaus, S.; Grimmond, S.

    2013-12-01

    Urbanization-induced change in land use has considerable implications for climate, air quality, resources and ecosystems. Urban-induced warming is one of the most well-known impacts. This directly and indirectly can extend beyond the city. One way to reduce the size of this is to modify the surface atmosphere exchanges through changing the urban albedo. As increased rugosity caused by the morphology of a city results in lower albedo with constant material characteristics, the impacts of changing the albedo has impacts across a range of scales. Here a multi-scale assessment of the potential effects of the increase in albedo in London is presented. This includes modeling at the global and meso-scale informed by local and micro-scale measurements. In this study the first order calculations are conducted for the impact of changing the albedo (e.g. a 0.01 increase) on the radiative exchange. For example, when incoming solar radiation and cloud cover are considered, based on data retrieved from NASA (http://power.larc.nasa.gov/) for ~1600 km2 area of London, would produce a mean decrease in the instantaneous solar radiative forcing on the same surface of 0.40 W m-2. The nature of the surface is critical in terms of considering the impact of changes in albedo. For example, in the Central Activity Zone in London pavement and building can vary from 10 to 100% of the plan area. From observations the albedo is seen to change dramatically with changes in building materials. For example, glass surfaces which are being used increasingly in the central business district results in dramatic changes in albedo. Using the documented albedo variations determined across different scales the impacts are considered. For example, the effect of the increase in urban albedo is translated into the corresponding amount of avoided emission of carbon dioxide that produces the same effect on climate. At local scale, the effect that the increase in urban albedo can potentially have on local

  20. Understanding in-situ ozone production in the summertime through radical observations and modelling studies during the Clean air for London project

    NASA Astrophysics Data System (ADS)

    Whalley, Lisa; Stone, Daniel; Sharp, Thomas; Garraway, Shani; Bannan, Thomas; Percival, Carl; Hopkins, James; Holmes, Rachel; Hamilton, Jacqui; Lee, James; Laufs, Sebastian; Kleffmann, Jörg; Heard, Dwayne

    2014-05-01

    With greater than 50 % of the global population residing in urban conurbations, poor urban air quality has a demonstrable effect on human health. OH and HO2 radicals, (collectively termed HOx) together with RO2 radicals, mediate virtually all of the oxidative chemistry in the atmosphere, being responsible for the transformation of primary emissions into secondary pollutants such as NO2, O3 and particulates. Here we present measurements of OH, HO2, partially speciated RO2 (distinguishing smaller alkane related RO2 from larger alkane/alkene/aromatic related RO2), ClNO2 and OH reactivity measurements taken during the ClearfLo campaign in central London in the summer of 2012. Comparison with calculations from a detailed box model utilising the Master Chemical Mechanism v3.2 tested our ability to reproduce radical levels, and enabled detailed radical budgets to be determined, highlighting for example the important role of the photolysis of nitrous acid (HONO) and carbonyl species as radical sources. Speciation of RO2 enabled the break-down of ozone production from different classes of VOCs to be calculated directly and compared with model calculations. Summertime observations of radicals have helped to identify that increases in photolytic sources of radicals on warm, sunny days can significantly increase local ozone concentrations leading to exceedances of EU air quality recommendations of 60 ppbV. The photolytic breakdown of ClNO2 to Cl atoms can more than double radical concentrations in the early morning; although the integrated increase in radical concentrations over a 24 hr period in model runs when ClNO2 photolysis is included is more modest. On average we calculate just under a 1 ppb increase in ozone due to the presence of ClNO2 in London air. OH reactivity was found to be greatest during morning and evening rush hours. Good agreement between the modelled OH reactivity and observations could be achieved when reactivity associated with model generated photo

  1. Late Oligocene and Early Miocene Muroidea of the Zinda Pir Dome.

    PubMed

    Lindsay, Everett H; Flynn, Lawrence J

    2016-02-17

    A series of Oligocene through Early Miocene terrestrial deposits preserved in the foothills of the Zinda Pir Dome of western Pakistan produce multiple, superposed fossil mammal localities. These include small mammal assemblages that shed light on the evolution of rodent lineages, especially Muroidea, in South Asia. Nine small mammal localities span approximately 28-19 Ma, an interval encompassing the Oligocene-Miocene boundary. The Early Miocene rodent fossil assemblages are dominated by muroid rodents, but muroids are uncommon and archaic in earlier Oligocene horizons. The Zinda Pir sequence includes the evolutionary transition to modern Muroidea at about the Oligocene-Miocene boundary. We review the muroid record for the Zinda Pir Dome, which includes the early radiation of primitive bamboo rats (Rhizomyinae) and early members of the modern muroid radiation, which lie near crown Cricetidae and Muridae. The Zinda Pir record dates diversification of modern muroids in the Indian Subcontintent and establishment by 19 Ma of muroid assemblages characteristic of the later Siwaliks.

  2. A 28,000 Years Old Cro-Magnon mtDNA Sequence Differs from All Potentially Contaminating Modern Sequences

    PubMed Central

    Caramelli, David; Milani, Lucio; Vai, Stefania; Modi, Alessandra; Pecchioli, Elena; Girardi, Matteo; Pilli, Elena; Lari, Martina; Lippi, Barbara; Ronchitelli, Annamaria; Mallegni, Francesco; Casoli, Antonella; Bertorelle, Giorgio; Barbujani, Guido

    2008-01-01

    Background DNA sequences from ancient speciments may in fact result from undetected contamination of the ancient specimens by modern DNA, and the problem is particularly challenging in studies of human fossils. Doubts on the authenticity of the available sequences have so far hampered genetic comparisons between anatomically archaic (Neandertal) and early modern (Cro-Magnoid) Europeans. Methodology/Principal Findings We typed the mitochondrial DNA (mtDNA) hypervariable region I in a 28,000 years old Cro-Magnoid individual from the Paglicci cave, in Italy (Paglicci 23) and in all the people who had contact with the sample since its discovery in 2003. The Paglicci 23 sequence, determined through the analysis of 152 clones, is the Cambridge reference sequence, and cannot possibly reflect contamination because it differs from all potentially contaminating modern sequences. Conclusions/Significance: The Paglicci 23 individual carried a mtDNA sequence that is still common in Europe, and which radically differs from those of the almost contemporary Neandertals, demonstrating a genealogical continuity across 28,000 years, from Cro-Magnoid to modern Europeans. Because all potential sources of modern DNA contamination are known, the Paglicci 23 sample will offer a unique opportunity to get insight for the first time into the nuclear genes of early modern Europeans. PMID:18628960

  3. Simulating secondary organic aerosol from missing diesel-related intermediate-volatility organic compound emissions during the Clean Air for London (ClearfLo) campaign

    NASA Astrophysics Data System (ADS)

    Ots, Riinu; Young, Dominique E.; Vieno, Massimo; Xu, Lu; Dunmore, Rachel E.; Allan, James D.; Coe, Hugh; Williams, Leah R.; Herndon, Scott C.; Ng, Nga L.; Hamilton, Jacqueline F.; Bergström, Robert; Di Marco, Chiara; Nemitz, Eiko; Mackenzie, Ian A.; Kuenen, Jeroen J. P.; Green, David C.; Reis, Stefan; Heal, Mathew R.

    2016-05-01

    We present high-resolution (5 km × 5 km) atmospheric chemical transport model (ACTM) simulations of the impact of newly estimated traffic-related emissions on secondary organic aerosol (SOA) formation over the UK for 2012. Our simulations include additional diesel-related intermediate-volatility organic compound (IVOC) emissions derived directly from comprehensive field measurements at an urban background site in London during the 2012 Clean Air for London (ClearfLo) campaign. Our IVOC emissions are added proportionally to VOC emissions, as opposed to proportionally to primary organic aerosol (POA) as has been done by previous ACTM studies seeking to simulate the effects of these missing emissions. Modelled concentrations are evaluated against hourly and daily measurements of organic aerosol (OA) components derived from aerosol mass spectrometer (AMS) measurements also made during the ClearfLo campaign at three sites in the London area. According to the model simulations, diesel-related IVOCs can explain on average ˜ 30 % of the annual SOA in and around London. Furthermore, the 90th percentile of modelled daily SOA concentrations for the whole year is 3.8 µg m-3, constituting a notable addition to total particulate matter. More measurements of these precursors (currently not included in official emissions inventories) is recommended. During the period of concurrent measurements, SOA concentrations at the Detling rural background location east of London were greater than at the central London location. The model shows that this was caused by an intense pollution plume with a strong gradient of imported SOA passing over the rural location. This demonstrates the value of modelling for supporting the interpretation of measurements taken at different sites or for short durations.

  4. Ethnic variations in pathways into early intervention services for psychosis.

    PubMed

    Ghali, Sharif; Fisher, Helen L; Joyce, John; Major, Barnaby; Hobbs, Lorna; Soni, Sujata; Chisholm, Brock; Rahaman, Nikola; Papada, Peggy; Lawrence, Jo; Bloy, Sally; Marlowe, Karl; Aitchison, Katherine J; Power, Paddy; Johnson, Sonia

    2013-04-01

    Ethnic variations have previously been identified in the duration of untreated psychosis (DUP) and pathways into psychiatric services. These have not been examined in the context of early intervention services, which may alter these trajectories. To explore ethnic differences in the nature and duration of pathways into early intervention services. In a naturalistic cohort study, data were collected for 1024 individuals with psychotic disorders accepted for case management by eight London early intervention services. Duration of untreated psychosis was prolonged in the White British group compared with most other ethnic groups. White British individuals were more likely to make contact with their general practitioner and less likely to be seen within emergency medical services. All Black patient groups were more likely than their White British counterparts to experience involvement of criminal justice agencies. Variations continue to exist in how and when individuals from different ethnic groups access early intervention services. These may account for disparities in DUP.

  5. The role of load-carrying in the evolution of modern body proportions.

    PubMed

    Wang, W-J; Crompton, R H

    2004-05-01

    The first unquestionably bipedal early human ancestors, the species Australopithecus afarensis, were markedly different to ourselves in body proportions, having a long trunk and short legs. Some have argued that 'chimpanzee-like' features such as these suggest a 'bent-hip, bent-knee' (BHBK) posture would have been adopted during gait. Computer modelling studies, however, indicate that this early human ancestor could have walked in a reasonably efficient upright posture, whereas BHBK posture would have nearly doubled the mechanical energy cost of locomotion, as it does the physiological cost of locomotion in ourselves. More modern body proportions first appear at around 1.8-1.5 Ma, with Homo ergaster (early African Homo erectus), represented by the Nariokotome skeleton KNM-WT 15000, in which the legs were considerably longer in relation to the trunk than they are in human adults, although this skeleton represents an adolescent. Several authors have suggested that this morphology would have allowed faster, more endurant walking. But during the same period, the archaeological record indicates a sharp rise in distances over which stone tools or raw materials are transported. Is this coincidental, or can load-carrying also be implicated in selection for a more modern morphology? Computer simulations of loaded walking, verified against kinetic data for humans, show that BHBK gait is even more ineffective while load-carrying. However, walking erect, the Nariokotome individual could have carried loads of 10-15% body mass for less cost, relative to body size, than AL 288-1 walking erect but unloaded. In fact, to the extent that our sample of humans is typical, KNM-WT 15000 would have had better mechanical effectiveness in bearing light loads on the back than modern human adults. Thus, selection for effectiveness in load-carrying, as well as in endurant walking, is indeed likely to have been implicated in the evolution of modern body proportions.

  6. Modern pentathlon and the First World War: when athletes and soldiers met to practise martial manliness.

    PubMed

    Heck, Sandra

    2011-01-01

    In the nationalistic atmosphere of the early twentieth century, a nurturing medium for sports practising martial manliness abounded throughout Europe. This framework supported the invention of a new multi-disciplinary sport, aided by Baron Pierre de Coubertin himself: modern pentathlon. Though the idea of a new form of pentathlon was already born in 1894, it took 30 years, until Paris 1924, to establish modern pentathlon within the Olympic Games. This study is concerned with the reasons for that delay. It will be assessed whether the active military preparations around the First World War and the contemporary image of masculinity had a decisive influence on the early history of modern pentathlon. By including historical documents from the IOC archives in Lausanne, Switzerland, the research office for military history in Potsdam, Germany, and the LA84 Foundation in Los Angeles, USA, as well as literature on gender, military sport and Olympic history, this study offers an entirely new view on the early history of a sport that was born in an atmosphere of glorifying manliness and apparent militarism. The history of modern pentathlon thereby provides a particularly appropriate area for the analysis of connections between sport, militarism and masculinity. It was not by chance that the implementation of a combined sport, which included besides swimming and running the three military disciplines of shooting, fencing and horse riding, arose in a pre-war context. Though in 1912 the Great War had not yet begun, the awareness of an upcoming battle was rising and led to a higher attention to Coubertin's almost forgotten assumption of a new sport. In 1924 the advantages were finally admitted on two sides: the army recruited modern pentathletes as future military officers; the sports community appointed skilled officers as successful competitors. Thus the lobby for an Olympic recognition of modern pentathlon was found.

  7. Conference Scene: Summary report from EAACI: London 2010.

    PubMed

    Stiehm, Matthias; Bufe, Albrecht

    2010-09-01

    Immunotherapy is, to date, the only effective curative method for the treatment of allergic disorders. Great efforts have been made to improve the efficacy, safety and patient compliance with this method. The growing understanding of the immunological mechanisms underlying immunotherapy has led to new approaches for immunotherapy involving the routes of administration and the kinds of molecules used. In addition, new vaccines are being created that combine the advantageous immunological charasteristics of different substances, such as virus-like particles linked to allergens. Many new results from ongoing research into these topics were presented at the 29th congress of the European Academy of Allergy and Clinical Immunology in London.

  8. Scenarios of London Local Authorities' Engagement with Evidence Bases for Education Policies

    ERIC Educational Resources Information Center

    Al Hallami, Mariam; Brown, Chris

    2014-01-01

    This paper examines the use of research and evidence in the formation of education policy within London local authorities. In particular it explores the policy processes in three local authorities, and observes the role of research and the interplay between research and policy within each. We begin the paper with a general overview of policy…

  9. Continuous bioprocessing: the real thing this time? 10(th) Annual bioProcessUK Conference, December 3-4, 2013, London, UK.

    PubMed

    Farid, Suzanne S; Thompson, Bill; Davidson, Andrew

    2014-01-01

    The Annual bioProcessUK Conference has acted as the key networking event for bioprocess scientists and engineers in the UK for the past 10 years. The following article is a report from the sessions that focused on continuous bioprocessing during the 10(th) Annual bioProcessUK Conference (London, December 2013). These sessions were organized by the 'EPSRC Centre for Innovative Manufacturing in Emergent Macromolecular Therapies' hosted at University College London. A plenary lecture and workshop provided a forum for participants to debate topical issues in roundtable discussions with industry and academic experts from institutions such as Genzyme, Janssen, Novo Nordisk, Pfizer, Merck, GE Healthcare and University College London. The aim of these particular sessions was to understand better the challenges and opportunities for continuous bioprocessing in the bioprocessing sector.

  10. Morphological Integration of the Modern Human Mandible during Ontogeny

    PubMed Central

    Polanski, Joshua M.

    2011-01-01

    Craniofacial integration is prevalent in anatomical modernity research. Little investigation has been done on mandibular integration. Integration patterns were quantified in a longitudinal modern human sample of mandibles. This integration pattern is one of modularization between the alveolar and muscle attachment regions, but with age-specific differences. The ascending ramus and nonalveolar portions of the corpus remain integrated throughout ontogeny. The alveolar region is dynamic, becoming modularized according to the needs of the mandible at a particular developmental stage. Early in ontogeny, this modularity reflects the need for space for the developing dentition; later, modularity is more reflective of mastication. The overall pattern of modern human mandibular integration follows the integration pattern seen in other mammals, including chimpanzees. Given the differences in craniofacial integration patterns between humans and chimpanzees, but the similarities in mandibular integration, it is likely that the mandible has played the more passive role in hominin skull evolution. PMID:21716741

  11. London-born black Caribbean children are at increased risk of atopic dermatitis.

    PubMed

    Williams, H C; Pembroke, A C; Forsdyke, H; Boodoo, G; Hay, R J; Burney, P G

    1995-02-01

    Previous reports suggest that atopic dermatitis is more common in black Caribbean children born in the United Kingdom than in white children. It is unclear whether these differences are caused by selection bias or variations in the use of the word "eczema" in the groups studied. Our objective was to explore ethnic group differences in the prevalence of atopic dermatitis in London schoolchildren. A cross-sectional prevalence survey of 693 junior school children in three schools was performed. Atopic dermatitis was defined in three ways: (1) by a dermatologist, (2) by visible flexural dermatitis as recorded by an independent observer, and (3) by a history of flexural dermatitis according to the child's parents. The prevalence of atopic dermatitis according to examination by a dermatologist was 16.3% in black Caribbean children and 8.7% in white children. This increased risk was present for different methods of defining of a atopic dermatitis and persisted after adjustment for potential confounders. London-born black Caribbean children appear to be at an increased risk of having atopic dermatitis.

  12. The Incidence of Sixteenth Century Cosmic Models in Modern Texts

    NASA Astrophysics Data System (ADS)

    Maene, S. A.; Best, J. S.; Usher, P. D.

    1999-12-01

    In the sixteenth century, the bounded cosmological models of Copernicus (1543) and Tycho Brahe (1588), and the unbounded model of Thomas Digges (1576), vied with the bounded geocentric model of Ptolemy (c. 140 AD). The work of the philosopher Giordano Bruno in 1584 lent further support to the Digges model. Despite the eventual acceptance of the unbounded universe, analysis of over 100 modern introductory astronomy texts reveals that these early unbounded models are mentioned infrequently. The ratio of mentions of Digges' model to Copernicus' model has the surprisingly low value of R = 0.08. The philosophical speculation of Bruno receives mention more than twice as often (R = 0.17). The expectation that these early unbounded models warrant inclusion in astronomy texts is supported both by modern hindsight and by the literature of the time. In Shakespeare's "Hamlet" of c. 1601, Prince Hamlet suffers from two transformations. According to the cosmic allegorical model, one transformation changes the bounded geocentricism of Ptolemy to the bounded heliocentricism of Copernicus, while the other completes the change to Digges' model of the infinite universe of suns. This interpretation and the modern world view suggest that both transformations should receive equal mention and thus that the ratio R in introductory texts should be close to unity. This work was supported in part by the NASA West Virginia Space Grant Consortium.

  13. Meeting Patient and Professional Needs: Views of Stakeholders on a Training Initiative for DwSIs in Endodontics in London.

    PubMed

    Al-Haboubi, Mustafa; Newton, Paul; Gallagher, Jennifer E

    2016-05-01

    A pilot scheme was established across London to train NHS primary dental care practitioners to provide endodontic treatment of moderate difficulty. It was co-led by the former London Deanery (Health Education England: North West London) and local NHS commissioners. This research aimed to explore key stakeholders' perceptions about the purpose of the initiative, its advantages, disadvantages and future implications. Nineteen semi-structured interviews were conducted with stakeholders (commissioners and providers of the educational initiative; commissioners and providers of care, including trainees, principal dentists and specialists) involved in establishing, running and participating in the initiative and wider endodontic service provision in London. Interviews were based on a topic guide informed by the literature, and a workshop involving the London trainees. Interviews were recorded, transcribed and analysed using framework methodology. The project was perceived as supporting four key areas: addressing services, improving quality/outcomes, delivering education and enhancing professional status. There was evidence that dentists were harnessing health policy in facilitating 'reprofessionalisation' of dentistry with the creation of dentists with enhanced skills (DwSIs). Learning outcomes from the pilot were related to the accreditation of the participants, service tariffs, reimbursement for endodontic treatment on the NHS, and the need for continuity within and between services across the dental system. Uncertainty about funding and the changes within the NHS were among the concerns expressed regarding the future of the initiative. The findings of this research suggest that extending the skills of primary care practitioners may contribute to the reprofessionalisation of dentistry, which has much to contribute to patient care and the development of an integrated and accessible dental care system of quality, with improved outcomes for patients. The implications for

  14. An Olympic Legacy? Did the Urban Regeneration Associated With the London 2012 Olympic Games Influence Adolescent Mental Health?

    PubMed

    Clark, Charlotte; Smuk, Melanie; Cummins, Steven; Eldridge, Sandra; Fahy, Amanda; Lewis, Daniel; Moore, Derek G; Smith, Neil; Taylor, Stephanie J C; Stansfeld, Stephen A

    2018-03-01

    Public expenditure on large events such as the London 2012 Olympic Games is often justified by the potential legacy of urban regeneration and its associated health and well-being benefits for local communities. In the Olympic Regeneration in East London Study, we examined whether there was an association between urban regeneration related to the 2012 Games and improved mental health in young people. Adolescents aged 11-12 years attending schools in the Olympic host borough of Newham in London or in 3 adjacent comparison London boroughs completed a survey before the 2012 Games and 6 and 18 months after the Games (in 2013 and 2014, respectively). Changes in depressive symptoms and well-being between baseline and each follow-up were examined. A total of 2,254 adolescents from 25 randomly selected schools participated. Adolescents from Newham were more likely to have remained depressed between baseline and the 6- and 18-month follow-up surveys (for 6-month follow-up, relative risk = 1.78, 95% confidence interval: 1.12, 2.83; for 18-month follow-up, relative risk = 1.93, 95% confidence interval: 1.01, 3.70) than adolescents from the comparison boroughs. No differences in well-being were observed. There was little evidence that urban regeneration had any positive influence on adolescent mental health and some suggestion that regeneration may have been associated with maintenance of depressive symptoms. Such programs may have limited short-term impact on the mental health of adolescents.

  15. Genetic analysis of lice supports direct contact between modern and archaic humans.

    PubMed

    Reed, David L; Smith, Vincent S; Hammond, Shaless L; Rogers, Alan R; Clayton, Dale H

    2004-11-01

    Parasites can be used as unique markers to investigate host evolutionary history, independent of host data. Here we show that modern human head lice, Pediculus humanus, are composed of two ancient lineages, whose origin predates modern Homo sapiens by an order of magnitude (ca. 1.18 million years). One of the two louse lineages has a worldwide distribution and appears to have undergone a population bottleneck ca. 100,000 years ago along with its modern H. sapiens host. Phylogenetic and population genetic data suggest that the other lineage, found only in the New World, has remained isolated from the worldwide lineage for the last 1.18 million years. The ancient divergence between these two lice is contemporaneous with splits among early species of Homo, and cospeciation analyses suggest that the two louse lineages codiverged with a now extinct species of Homo and the lineage leading to modern H. sapiens. If these lice indeed codiverged with their hosts ca. 1.18 million years ago, then a recent host switch from an archaic species of Homo to modern H. sapiens is required to explain the occurrence of both lineages on modern H. sapiens. Such a host switch would require direct physical contact between modern and archaic forms of Homo.

  16. Genetic Analysis of Lice Supports Direct Contact between Modern and Archaic Humans

    PubMed Central

    Smith, Vincent S; Hammond, Shaless L; Rogers, Alan R; Clayton, Dale H

    2004-01-01

    Parasites can be used as unique markers to investigate host evolutionary history, independent of host data. Here we show that modern human head lice, Pediculus humanus, are composed of two ancient lineages, whose origin predates modern Homo sapiens by an order of magnitude (ca. 1.18 million years). One of the two louse lineages has a worldwide distribution and appears to have undergone a population bottleneck ca. 100,000 years ago along with its modern H. sapiens host. Phylogenetic and population genetic data suggest that the other lineage, found only in the New World, has remained isolated from the worldwide lineage for the last 1.18 million years. The ancient divergence between these two lice is contemporaneous with splits among early species of Homo, and cospeciation analyses suggest that the two louse lineages codiverged with a now extinct species of Homo and the lineage leading to modern H. sapiens. If these lice indeed codiverged with their hosts ca. 1.18 million years ago, then a recent host switch from an archaic species of Homo to modern H. sapiens is required to explain the occurrence of both lineages on modern H. sapiens. Such a host switch would require direct physical contact between modern and archaic forms of Homo. PMID:15502871

  17. The London Association for the Teaching of English 1947-67: A History

    ERIC Educational Resources Information Center

    Gibbons, Simon

    2013-01-01

    This is the fascinating story of the birth, growth, and development of the London Association for the Teaching of English from its earliest years through to the formation of the National Association for the Teaching of English and thereafter. The work of founder members of LATE, such as James Britton, Harold Rosen, and Nancy Martin, was critical…

  18. Two waves of colonization straddling the K-Pg boundary formed the modern reef fish fauna.

    PubMed

    Price, S A; Schmitz, L; Oufiero, C E; Eytan, R I; Dornburg, A; Smith, W L; Friedman, M; Near, T J; Wainwright, P C

    2014-05-22

    Living reef fishes are one of the most diverse vertebrate assemblages on Earth. Despite its prominence and ecological importance, the origins and assembly of the reef fish fauna is poorly described. A patchy fossil record suggests that the major colonization of reef habitats must have occurred in the Late Cretaceous and early Palaeogene, with the earliest known modern fossil coral reef fish assemblage dated to 50 Ma. Using a phylogenetic approach, we analysed the early evolutionary dynamics of modern reef fishes. We find that reef lineages successively colonized reef habitats throughout the Late Cretaceous and early Palaeogene. Two waves of invasion were accompanied by increasing morphological convergence: one in the Late Cretaceous from 90 to 72 Ma and the other immediately following the end-Cretaceous mass extinction. The surge in reef invasions after the Cretaceous-Palaeogene boundary continued for 10 Myr, after which the pace of transitions to reef habitats slowed. Combined, these patterns match a classic niche-filling scenario: early transitions to reefs were made rapidly by morphologically distinct lineages and were followed by a decrease in the rate of invasions and eventual saturation of morphospace. Major alterations in reef composition, distribution and abundance, along with shifts in climate and oceanic currents, occurred during the Late Cretaceous and early Palaeogene interval. A causal mechanism between these changes and concurrent episodes of reef invasion remains obscure, but what is clear is that the broad framework of the modern reef fish fauna was in place within 10 Myr of the end-Cretaceous extinction.

  19. Two waves of colonization straddling the K–Pg boundary formed the modern reef fish fauna

    PubMed Central

    Price, S. A.; Schmitz, L.; Oufiero, C. E.; Eytan, R. I.; Dornburg, A.; Smith, W. L.; Friedman, M.; Near, T. J.; Wainwright, P. C.

    2014-01-01

    Living reef fishes are one of the most diverse vertebrate assemblages on Earth. Despite its prominence and ecological importance, the origins and assembly of the reef fish fauna is poorly described. A patchy fossil record suggests that the major colonization of reef habitats must have occurred in the Late Cretaceous and early Palaeogene, with the earliest known modern fossil coral reef fish assemblage dated to 50 Ma. Using a phylogenetic approach, we analysed the early evolutionary dynamics of modern reef fishes. We find that reef lineages successively colonized reef habitats throughout the Late Cretaceous and early Palaeogene. Two waves of invasion were accompanied by increasing morphological convergence: one in the Late Cretaceous from 90 to 72 Ma and the other immediately following the end-Cretaceous mass extinction. The surge in reef invasions after the Cretaceous–Palaeogene boundary continued for 10 Myr, after which the pace of transitions to reef habitats slowed. Combined, these patterns match a classic niche-filling scenario: early transitions to reefs were made rapidly by morphologically distinct lineages and were followed by a decrease in the rate of invasions and eventual saturation of morphospace. Major alterations in reef composition, distribution and abundance, along with shifts in climate and oceanic currents, occurred during the Late Cretaceous and early Palaeogene interval. A causal mechanism between these changes and concurrent episodes of reef invasion remains obscure, but what is clear is that the broad framework of the modern reef fish fauna was in place within 10 Myr of the end-Cretaceous extinction. PMID:24695431

  20. Ethnic inequalities in dental caries among adults in East London.

    PubMed

    Delgado-Angulo, Elsa K; Bernabé, Eduardo; Marcenes, Wagner

    2016-06-01

    This study explored ethnic inequalities in dental caries among adults and assessed the role of socioeconomic position (SEP) in explaining those inequalities. We analysed data on 2013 adults aged 16-65 years, from the East London Oral Health Inequality (ELOHI) Study, which included a random sample of adults and children living in East London in 2009-10. Participants completed a questionnaire and were clinically examined for dental caries at home. Dental caries was measured using the number of decayed, missing and filled teeth or DMFT index. Ethnic inequalities in dental caries were assessed in negative binomial regression models before and after adjustment for demographic (sex and age groups) and SEP measures (education and socioeconomic classification). White Eastern European and White Other had higher DMFT, whereas all Asian (Pakistani, Indian, Bangladeshi and Other) and all Black (African, Caribbean and Other) ethnic groups had lower DMFT than White British. Similar inequalities were found for the number of filled and missing teeth, but there were no differences in the number of decayed teeth between ethnic groups. This study showed considerable disparities in dental caries between and within the major ethnic categories, which were independent of demographics and SEP. © The Author 2015. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  1. An early modern human presence in Sumatra 73,000-63,000 years ago.

    PubMed

    Westaway, K E; Louys, J; Awe, R Due; Morwood, M J; Price, G J; Zhao, J-X; Aubert, M; Joannes-Boyau, R; Smith, T M; Skinner, M M; Compton, T; Bailey, R M; van den Bergh, G D; de Vos, J; Pike, A W G; Stringer, C; Saptomo, E W; Rizal, Y; Zaim, J; Santoso, W D; Trihascaryo, A; Kinsley, L; Sulistyanto, B

    2017-08-17

    Genetic evidence for anatomically modern humans (AMH) out of Africa before 75 thousand years ago (ka) and in island southeast Asia (ISEA) before 60 ka (93-61 ka) predates accepted archaeological records of occupation in the region. Claims that AMH arrived in ISEA before 60 ka (ref. 4) have been supported only by equivocal or non-skeletal evidence. AMH evidence from this period is rare and lacks robust chronologies owing to a lack of direct dating applications, poor preservation and/or excavation strategies and questionable taxonomic identifications. Lida Ajer is a Sumatran Pleistocene cave with a rich rainforest fauna associated with fossil human teeth. The importance of the site is unclear owing to unsupported taxonomic identification of these fossils and uncertainties regarding the age of the deposit, therefore it is rarely considered in models of human dispersal. Here we reinvestigate Lida Ajer to identify the teeth confidently and establish a robust chronology using an integrated dating approach. Using enamel-dentine junction morphology, enamel thickness and comparative morphology, we show that the teeth are unequivocally AMH. Luminescence and uranium-series techniques applied to bone-bearing sediments and speleothems, and coupled uranium-series and electron spin resonance dating of mammalian teeth, place modern humans in Sumatra between 73 and 63 ka. This age is consistent with biostratigraphic estimations, palaeoclimate and sea-level reconstructions, and genetic evidence for a pre-60 ka arrival of AMH into ISEA. Lida Ajer represents, to our knowledge, the earliest evidence of rainforest occupation by AMH, and underscores the importance of reassessing the timing and environmental context of the dispersal of modern humans out of Africa.

  2. An early modern human presence in Sumatra 73,000-63,000 years ago

    NASA Astrophysics Data System (ADS)

    Westaway, K. E.; Louys, J.; Awe, R. Due; Morwood, M. J.; Price, G. J.; Zhao, J.-X.; Aubert, M.; Joannes-Boyau, R.; Smith, T. M.; Skinner, M. M.; Compton, T.; Bailey, R. M.; van den Bergh, G. D.; de Vos, J.; Pike, A. W. G.; Stringer, C.; Saptomo, E. W.; Rizal, Y.; Zaim, J.; Santoso, W. D.; Trihascaryo, A.; Kinsley, L.; Sulistyanto, B.

    2017-08-01

    Genetic evidence for anatomically modern humans (AMH) out of Africa before 75 thousand years ago (ka) and in island southeast Asia (ISEA) before 60 ka (93-61 ka) predates accepted archaeological records of occupation in the region. Claims that AMH arrived in ISEA before 60 ka (ref. 4) have been supported only by equivocal or non-skeletal evidence. AMH evidence from this period is rare and lacks robust chronologies owing to a lack of direct dating applications, poor preservation and/or excavation strategies and questionable taxonomic identifications. Lida Ajer is a Sumatran Pleistocene cave with a rich rainforest fauna associated with fossil human teeth. The importance of the site is unclear owing to unsupported taxonomic identification of these fossils and uncertainties regarding the age of the deposit, therefore it is rarely considered in models of human dispersal. Here we reinvestigate Lida Ajer to identify the teeth confidently and establish a robust chronology using an integrated dating approach. Using enamel-dentine junction morphology, enamel thickness and comparative morphology, we show that the teeth are unequivocally AMH. Luminescence and uranium-series techniques applied to bone-bearing sediments and speleothems, and coupled uranium-series and electron spin resonance dating of mammalian teeth, place modern humans in Sumatra between 73 and 63 ka. This age is consistent with biostratigraphic estimations, palaeoclimate and sea-level reconstructions, and genetic evidence for a pre-60 ka arrival of AMH into ISEA. Lida Ajer represents, to our knowledge, the earliest evidence of rainforest occupation by AMH, and underscores the importance of reassessing the timing and environmental context of the dispersal of modern humans out of Africa.

  3. Asthma length of stay in hospitals in London 2001-2006: demographic, diagnostic and temporal factors.

    PubMed

    Soyiri, Ireneous N; Reidpath, Daniel D; Sarran, Christophe

    2011-01-01

    Asthma is a condition of significant public health concern associated with morbidity, mortality and healthcare utilisation. This study identifies key determinants of length of stay (LOS) associated with asthma-related hospital admissions in London, and further explores their effects on individuals. Subjects were primarily diagnosed and admitted for asthma in London between 1(st) January 2001 and 31(st) December 2006. All repeated admissions were treated uniquely as independent cases. Negative binomial regression was used to model the effect(s) of demographic, temporal and diagnostic factors on the LOS, taking into account the cluster effect of each patient's hospital attendance in London. The median and mean asthma LOS over the period of study were 2 and 3 days respectively. Admissions increased over the years from 8,308 (2001) to 10,554 (2006), but LOS consistently declined within the same period. Younger individuals were more likely to be admitted than the elderly, but the latter significantly had higher LOS (p<0.001). Respiratory related secondary diagnoses, age, and gender of the patient as well as day of the week and year of admission were important predictors of LOS. Asthma LOS can be predicted by socio-demographic factors, temporal and clinical factors using count models on hospital admission data. The procedure can be a useful tool for planning and resource allocation in health service provision.

  4. 33 CFR 334.75 - Thames River, Naval Submarine Base New London, restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Thames River, Naval Submarine....75 Thames River, Naval Submarine Base New London, restricted area. (a) The area: The open waters of... restricted area provided their vessels display registration numbers issued by the Naval Submarine Base, New...

  5. 33 CFR 334.75 - Thames River, Naval Submarine Base New London, restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Thames River, Naval Submarine....75 Thames River, Naval Submarine Base New London, restricted area. (a) The area: The open waters of... restricted area provided their vessels display registration numbers issued by the Naval Submarine Base, New...

  6. "It is caused of the womans part or of the mans part": the role of gender in the diagnosis and treatment of sexual dysfunction in early modern England.

    PubMed

    Evans, Jennifer

    2011-01-01

    Philip Barrough wrote in 1590 that barrenness 'is caused of the womans part or of the mans part'. By the eighteenth century, however, barrenness was perceived as a female disorder distinguished from male impotence. Few historians have addressed the uncertainty surrounding early modern definitions of infertility, choosing instead to adopt set terms that fit comfortably with modern ideas. This article will highlight the difficulties surrounding the gender distinction of the terms 'barrenness' and 'impotence' during this period. Moreover, the discussion will examine the role of gender in diagnosing these disorders to sufferers. The article will argue that ideas of gender were more central to diagnosis of poor sexual health than to effectual treatment. Although it appears that barrenness and impotence were treated with separate remedies, many treatments were described as effectual for both sexes. Additionally, the ingredients used in such recipes were often sexual stimulants explained without reference to gender.

  7. Development of a novel walkability index for London, United Kingdom: cross-sectional application to the Whitehall II Study.

    PubMed

    Stockton, Jemima C; Duke-Williams, Oliver; Stamatakis, Emmanuel; Mindell, Jennifer S; Brunner, Eric J; Shelton, Nicola J

    2016-05-18

    Physical activity is essential for health; walking is the easiest way to incorporate activity into everyday life. Previous studies report positive associations between neighbourhood walkability and walking but most focused on cities in North America and Australasia. Urban form with respect to street connectivity, residential density and land use mix-common components of walkability indices-differs in European cities. The objective of this study was to develop a walkability index for London and test the index using walking data from the Whitehall II Study. A neighbourhood walkability index for London was constructed, comprising factors associated with walking behaviours: residential dwelling density, street connectivity and land use mix. Three models were produced that differed in the land uses included. Neighbourhoods were operationalised at three levels of administrative geography: (i) 21,140 output areas, (ii) 633 wards and (iii) 33 local authorities. A neighbourhood walkability score was assigned to each London-dwelling Whitehall II Study participant (2003-04, N = 3020, mean ± SD age = 61.0 years ± 6.0) based on residential postcode. The effect of changing the model specification and the units of enumeration on spatial variation in walkability was examined. There was a radial decay in walkability from the centre to the periphery of London. There was high inter-model correlation in walkability scores for any given neighbourhood operationalisation (0.92-0.98), and moderate-high correlation between neighbourhood operationalisations for any given model (0.39-0.70). After adjustment for individual level factors and area deprivation, individuals in the most walkable neighbourhoods operationalised as wards were more likely to walk >6 h/week (OR = 1.4; 95 % CI: 1.1-1.9) than those in the least walkable. Walkability was associated with walking time in adults. This walkability index could help urban planners identify and design neighbourhoods in

  8. Engaging with the Public on Volcanic Risk through Hands-on Interaction with the London Volcano.

    NASA Astrophysics Data System (ADS)

    Rodgers, M.; Pyle, D. M.; Barclay, J.; Mather, T. A.; Hicks, A.; Ratner, J.; Leonard, H.; Woods, C.

    2015-12-01

    London Volcano is a major public engagement and outreach effort that emerged from a large-scale interdisciplinary research project on Strengthening Resilience in Volcanic Areas (STREVA). The activity was created for a 5-day public exhibition in London, in 2014, and brought together 3 elements to illustrate the timeline of a volcanic crisis: a 5m x 3m scale model of Soufrière St Vincent, an interactive 'monitoring station' to explore technology used in monitoring and an engaging 'bin bang' sequence to simulate a volcanic explosion. Having a large hands-on volcano as a centrepiece to the exhibit enabled interaction with primary-age school children through the use of creativity and imagination. They looked at seismic traces of 'bin bang' explosions; measured dispersal of projectile ducks; and decided where to place a model house on the island, on which the model volcano sat. Over the 5-days we evolved the activity of the volcano to re-create the 1902 eruption. During the first 3 days, 94 houses were placed around the volcano, but after the cataclysmic eruption mid-week, 12 of these houses were destroyed by simulated pyroclastic flows and lahars down the flanks of the volcano model. Light and sound were key parts of the London Volcano simulation. A sound track was created to mimic the sounds reported by eyewitnesses. Between eruptions, the volcano would intermittently rumble, adding excitement and unpredictability to the eruptions. Explosions were simulated with compressed-CO2 jets, and a G-flame; but these events were rare. Creative arts are an effective mechanism for transfer of knowledge from communities living with volcanic activity, so artwork from school children living near Tungurahua, Ecuador and poems from school children on Montserrat were on display. The London Volcano was a unique opportunity to engage with over 2,000 people on volcanic risk and what it means to live near a volcano. Encouraging school children to be creative and to use their imagination

  9. Epidemiology of adolescent substance use in London schools.

    PubMed

    Penney, J; Dargan, P I; Padmore, J; Wood, D M; Norman, I J

    2016-06-01

    Alcohol and substance use in adolescence can be associated with a range of health, emotional, social, behavioural and legal problems. There has been a change in the recreational drugs available to users in recent years; however, little is known about how this impacts the youngest and most vulnerable population of substance users. To investigate the prevalence of substance use among children aged 15-18 years in London schools. Questionnaire survey. Students aged 15-18 years in three London schools self-completed the questionnaire which collected demographic data (age, gender and ethnicity) and data on frequency of use of alcohol, tobacco and classical recreational drugs and novel psychoactive substances. Completed surveys were available from 533 students (47.8% of those invited to participate). One hundred thirteen (20.4%) students reported lifetime use of at least one recreational drug, cannabis (96, 18.7%) was commonly reported and only 6 (1.1%) reported use of a novel psychoactive substance. A total of 250 (47.8%) reported using alcohol at least once; those from White and Mixed ethnic groups were more likely to report using alcohol than those in other ethnic groups. A total of 382 (74.2%) students reported using tobacco at least once, and students from ethnic minorities were more likely to smoke than their White counterparts. This study supports previous findings that alcohol and drug use are declining in adolescents in UK. There are different patterns of substance use amongst different ethnic groups; this is important to schools and policymakers planning interventions related to substance use in school-aged children. © The Author 2015. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  10. Ethnopharmacy of Turkish-speaking Cypriots in Greater London.

    PubMed

    Yöney, Ahmet; Prieto, José M; Lardos, Andreas; Heinrich, Michael

    2010-05-01

    For centuries, in the Eastern Mediterranean region, medicinal plant use has been widely accepted as a treatment method for both minor and major diseases. Although some knowledge exists on the use of such medicinal plants within the Greek Cypriot culture and considerable information is available on various regions in Turkey, no detailed ethnopharmaceutical or ethnobotanical studies exist on Turkish-speaking Cypriots (TSC) both in Cyprus and within one of the largest TSC migrant communities in London, UK. Semi-structured interviews with members of the TSC community in London were conducted by using a questionnaire consisting both of open and closed questions. Open questions were aimed at identifying herbs, spices, medicinal plants and their uses. Also, graded questions were used to define informants' opinions as a quantitative parameter, constructing a statistical basis. A wide range of therapeutic claims were recorded, including 13 chronic illnesses within 85 different plant species, of which 18 were cited more than 10 times. The most frequently mentioned species were Mentha spicata, Salvia fruticosa and Pimpinella anisum. The plants recorded are frequently based on knowledge derived from Turkish-Cypriot traditions, but many examples of medicinal plants with a use based on UK or general western herbal medical traditions were also recorded. Informants highlighted the risk of knowledge loss in younger generations and thus this study serves as a repository of knowledge for use in the future. Due to a lack of knowledge about such usages in the healthcare professions, our study also highlights the need to develop information sources for use by healthcare practitioners in order to raise awareness about benefits and risks of such medical and health food products. Copyright (c) 2009 John Wiley & Sons, Ltd.

  11. Ancient origin of the modern deep-sea fauna.

    PubMed

    Thuy, Ben; Gale, Andy S; Kroh, Andreas; Kucera, Michal; Numberger-Thuy, Lea D; Reich, Mike; Stöhr, Sabine

    2012-01-01

    The origin and possible antiquity of the spectacularly diverse modern deep-sea fauna has been debated since the beginning of deep-sea research in the mid-nineteenth century. Recent hypotheses, based on biogeographic patterns and molecular clock estimates, support a latest Mesozoic or early Cenozoic date for the origin of key groups of the present deep-sea fauna (echinoids, octopods). This relatively young age is consistent with hypotheses that argue for extensive extinction during Jurassic and Cretaceous Oceanic Anoxic Events (OAEs) and the mid-Cenozoic cooling of deep-water masses, implying repeated re-colonization by immigration of taxa from shallow-water habitats. Here we report on a well-preserved echinoderm assemblage from deep-sea (1000-1500 m paleodepth) sediments of the NE-Atlantic of Early Cretaceous age (114 Ma). The assemblage is strikingly similar to that of extant bathyal echinoderm communities in composition, including families and genera found exclusively in modern deep-sea habitats. A number of taxa found in the assemblage have no fossil record at shelf depths postdating the assemblage, which precludes the possibility of deep-sea recolonization from shallow habitats following episodic extinction at least for those groups. Our discovery provides the first key fossil evidence that a significant part of the modern deep-sea fauna is considerably older than previously assumed. As a consequence, most major paleoceanographic events had far less impact on the diversity of deep-sea faunas than has been implied. It also suggests that deep-sea biota are more resilient to extinction events than shallow-water forms, and that the unusual deep-sea environment, indeed, provides evolutionary stability which is very rarely punctuated on macroevolutionary time scales.

  12. Risk of second malignancies in patients with early-stage classical Hodgkin's lymphoma treated in a modern era.

    PubMed

    LeMieux, Melissa H; Solanki, Abhishek A; Mahmood, Usama; Chmura, Steven J; Koshy, Matthew

    2015-04-01

    Second malignancies remain an issue affecting morbidity and mortality in long-term survivors of early stage Hodgkin's lymphoma (HL). We undertook this study to determine if treatment in the modern era resulted in decreased second malignancies. Patients diagnosed with stage I-II cHL between 1988 and 2009 who received radiation therapy (RT) were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Freedom from second malignancy (FFSM) was estimated using the Kaplan-Meier method. Univariate analysis (UVA) was performed using the Log-Rank test, and included age, gender, year of diagnosis, and stage. Multivariable analysis (MVA) was performed using Cox Proportional Hazards modeling. The study cohort included 8807 patients. The median age at diagnosis was 32 years (range: 2-85). The majority of patients had stage II disease (n = 6044, 69%), 597 (7%) had extranodal involvement (ENI), and 1925 (22%) had B symptoms. Median follow-up for the entire cohort was 7.2 years (range: 0-22). Five hundred twenty-three (6%) patients developed a second malignancy. Median latency to second malignancy was 5.8 years (range: 0.1-21.5). Of the 523 patients that developed a second malignancy, 228 (44%) occurred in the first 5 years, 139 (27%) were diagnosed between years 5-10, and 156 (30%) beyond 10 years. The 10 year FFSM for patients treated between 1988 and 1999 was 93.0% versus 95.1% for patients treated between 2000 and 2009 (P = 0.04), On MVA, treatment between 2000 and 2009 was associated with a HR for second malignancy of 0.77 (95% Confidence Interval: 0.62-0.96, P = 0.02) compared to the treatment between 1988 and 1999. Our analysis suggests that in patients treated with RT for stage I or II cHL, treatment prior to 2000 had a slightly higher risk of second malignancy compared to treatment in 2000 and later. Further studies, with longer follow-up of patients treated in the modern era are needed to confirm these findings. © 2015 The Authors. Cancer Medicine

  13. Dedicated outreach service for hard to reach patients with tuberculosis in London: observational study and economic evaluation.

    PubMed

    Jit, Mark; Stagg, Helen R; Aldridge, Robert W; White, Peter J; Abubakar, Ibrahim

    2011-09-14

    To assess the cost effectiveness of the Find and Treat service for diagnosing and managing hard to reach individuals with active tuberculosis. Economic evaluation using a discrete, multiple age cohort, compartmental model of treated and untreated cases of active tuberculosis. London, United Kingdom. Population Hard to reach individuals with active pulmonary tuberculosis screened or managed by the Find and Treat service (48 mobile screening unit cases, 188 cases referred for case management support, and 180 cases referred for loss to follow-up), and 252 passively presenting controls from London's enhanced tuberculosis surveillance system. Incremental costs, quality adjusted life years (QALYs), and cost effectiveness ratios for the Find and Treat service. The model estimated that, on average, the Find and Treat service identifies 16 and manages 123 active cases of tuberculosis each year in hard to reach groups in London. The service has a net cost of £1.4 million/year and, under conservative assumptions, gains 220 QALYs. The incremental cost effectiveness ratio was £6400-£10,000/QALY gained (about €7300-€11,000 or $10,000-$16 000 in September 2011). The two Find and Treat components were also cost effective, even in unfavourable scenarios (mobile screening unit (for undiagnosed cases), £18,000-£26,000/QALY gained; case management support team, £4100-£6800/QALY gained). Both the screening and case management components of the Find and Treat service are likely to be cost effective in London. The cost effectiveness of the mobile screening unit in particular could be even greater than estimated, in view of the secondary effects of infection transmission and development of antibiotic resistance.

  14. Interruption of the Tower of London Task: Support for a Goal-Activation Approach

    ERIC Educational Resources Information Center

    Hodgetts, Helen M.; Jones, Dylan M.

    2006-01-01

    Unexpected interruptions introduced during the execution phase of simple Tower of London problems incurred a time cost when the interrupted goal was retrieved, and this cost was exacerbated the longer the goal was suspended. Furthermore, time taken to retrieve goals was greater following a more complex interruption, indicating the processing…

  15. The London Geography Alliance: Re-Connecting the School Subject with the University Discipline

    ERIC Educational Resources Information Center

    Standish, Alex; Hawley, Duncan; Willy, Tessa

    2016-01-01

    The London Geography Alliance was established to provide a network of subject-based support to primary and secondary schools, by linking teachers and university lecturers. Workshops and fieldwork were conducted over a 17-month period to address different aspects of the geography curriculum. The effects of the project were evaluated using…

  16. Going for gold: blood planning for the London 2012 Olympic Games.

    PubMed

    Glasgow, S M; Allard, S; Rackham, R; Doughty, H

    2014-06-01

    The Olympics is one of the largest sporting events in the world. Major events may be complicated by disruption of normal activity and major incidents. Health care and transfusion planners should be prepared for both. Previously, transfusion contingency planning has focused on seasonal blood shortages and pandemic influenzas. This article is the first published account of transfusion contingency planning for a major event. We describe the issues encountered and the lessons identified during transfusion planning for the London 2012 Olympics. Planning was started 18 months in advance and was led by a project team reporting to the Executive. Planning was based on three periods of Gamestime. The requirements were planned with key stakeholders using normal processes enhanced by service developments. Demand planning was based on literature review together with computer modelling. The aim was blood-stock sufficiency complimented by a high readiness donor panel to minimise waste. Plans were widely communicated and table-top exercised. Full transfusion services were maintained during both Games with all demands met. The new service improvements and high readiness donors worked well. Emergency command and control have been upgraded. Red cell concentrate (RCC) stock aged but wastage was not significantly increased. The key to success was: early planning, stakeholder engagement, service developments, integration of transfusion service planning within the wider health care community and conduct within an assurance framework. © 2014 The Authors. Transfusion Medicine © 2014 British Blood Transfusion Society.

  17. A new surveillance system for undiagnosed serious infectious illness for the London 2012 Olympic and Paralympic Games.

    PubMed

    Heinsbroek, E; Said, B; Kirkbride, H

    2012-08-02

    A new surveillance system was developed to detect possible new or emerging infections presenting as undiagnosed serious infectious illness (USII) for use during the London 2012 Olympic and Paralympic Games. Designated clinicians in sentinel adult and paediatric intensive care units (ICU/ PICUs) reported USII using an online reporting tool or provided a weekly nil notification. Reported cases were investigated for epidemiological links. A pilot study was undertaken for six months between January and July 2011 to evaluate the feasibility and acceptability of the system. In this six-month period, 5 adults and 13 children were reported by six participating units (3 ICUs, 3 PICUs). Of these 18 patients, 12 were reported within four days after admission to an ICU/PICU. Nine patients were subsequently diagnosed and were thus excluded from the surveillance. Therefore, only nine cases of USII were reported. No clustering was identified.On the basis of the pilot study, we conclude that the system is able to detect cases of USII and is feasible and acceptable to users. USII surveillance has been extended to a total of 19 sentinel units in London and the south-east of England during the London 2012 Olympic and Paralympic Games.

  18. Speculative Truth - Henry Cavendish, Natural Philosophy, and the Rise of Modern Theoretical Science

    NASA Astrophysics Data System (ADS)

    McCormmach, Russell

    2004-03-01

    With a never-before published paper by Lord Henry Cavendish, as well as a biography on him, this book offers a fascinating discourse on the rise of scientific attitudes and ways of knowing. A pioneering British physicist in the late 18th and early 19th centuries, Cavendish was widely considered to be the first full-time scientist in the modern sense. Through the lens of this unique thinker and writer, this book is about the birth of modern science.

  19. Copy Right for Flight: Patterns of Technological Adaptation in Military Aviation

    DTIC Science & Technology

    2012-06-01

    Heppenheimer , A Brief History of Flight : From Balloons to Mach 3 and Beyond (New York: Wiley, 2001), 238. 4 Ronald E. Miller and David Sawers...Technical Development of Modern Aviation (London,: Routledge & K. Paul, 1968), 159. 7 T. A . Heppenheimer , A Brief History of Flight : From Balloons to...Modern Aviation (London,: Routledge & K. Paul, 1968), 165. 10 T. A . Heppenheimer , A Brief History of Flight : From Balloons to Mach 3 and Beyond (New

  20. The experience of agency nurses working in a London teaching hospital.

    PubMed

    Hass, Helen; Coyer, Fiona M; Theobald, Karen A

    2006-06-01

    This Husserlian phenomenological study explored the lived experience of eight full-time agency nurses working in the environment of intensive care in London, United Kingdom. In-depth interviews were used to ascertain the participants' experiences of full-time agency nursing in intensive care. Colaizzi's [Colaizzi P. Psychological research as the phenomenologist views it. In: Vale R, King M, editors. Existential-phenomenological alternatives for psychology. London: Oxford University Press; 1978, p. 48-71] method of data analysis was utilised. Thematic analysis identified three cluster themes: the shared experience of lacking confidence; the shared experience of deskilling; and the shared experience of feelings of isolation. The theme of the shared experience of lacking confidence identified the importance of support and understanding of agency nurses' needs in the ICU. The theme of the shared experience of deskilling illuminated participants concern at not having the opportunity to care for patients of higher acuity. The theme of the shared experience of feelings of isolation highlighted that often participants did not feel they "belonged to a team". Study findings suggest the need to include: the implementation of protocols within the clinical setting; the provision of performance feedback to agency nurses; and the consideration of ongoing structured professional development and education for ICU agency nurses.

  1. Forecasting asthma-related hospital admissions in London using negative binomial models.

    PubMed

    Soyiri, Ireneous N; Reidpath, Daniel D; Sarran, Christophe

    2013-05-01

    Health forecasting can improve health service provision and individual patient outcomes. Environmental factors are known to impact chronic respiratory conditions such as asthma, but little is known about the extent to which these factors can be used for forecasting. Using weather, air quality and hospital asthma admissions, in London (2005-2006), two related negative binomial models were developed and compared with a naive seasonal model. In the first approach, predictive forecasting models were fitted with 7-day averages of each potential predictor, and then a subsequent multivariable model is constructed. In the second strategy, an exhaustive search of the best fitting models between possible combinations of lags (0-14 days) of all the environmental effects on asthma admission was conducted. Three models were considered: a base model (seasonal effects), contrasted with a 7-day average model and a selected lags model (weather and air quality effects). Season is the best predictor of asthma admissions. The 7-day average and seasonal models were trivial to implement. The selected lags model was computationally intensive, but of no real value over much more easily implemented models. Seasonal factors can predict daily hospital asthma admissions in London, and there is a little evidence that additional weather and air quality information would add to forecast accuracy.

  2. [Side Effects of Modernity : Dam Building, Health Care, and the Construction of Power in the Context of the Control of Schistosomiasis in Egypt in the 1960s and early 1970s].

    PubMed

    Brendel, Benjamin

    2017-09-01

    This article analyzes the modernization campaigns in Egypt in the 1960s and early 1970s. The regulation of the Nile by the Aswan High Dam and the resulting irrigation projects caused the rate of schistosomiasis infestation in the population to rise. The result was a discourse between experts from the global north and Egyptian elites about modernization, development aid, dam building and health care. The fight against schistosomiasis was like a cipher, which combined different power-laden concepts and arguments. This article will decode the cipher and allow a deeper look into the contemporary dimensions of power bound to this subject. The text is conceived around three thematic axes. The first deals with the discursive interplay of modernization, health and development aid in and for Egypt. The second focuses on far-reaching and long-standing arguments within an international expert discourse about these concepts. Finally, the third presents an exemplary case study of West German health and development aid for fighting schistosomiasis in the Egyptian Fayoum oasis.

  3. Biological determinants of spontaneous late preterm and early term birth: a retrospective cohort study.

    PubMed

    Brown, H K; Speechley, K N; Macnab, J; Natale, R; Campbell, M K

    2015-03-01

    Our aim was to examine the association between biological determinants of preterm birth (infection and inflammation, placental ischaemia and other hypoxia, diabetes mellitus, other) and spontaneous late preterm (34-36 weeks) and early term (37-38 weeks) birth. Retrospective cohort study. City of London and Middlesex County, Canada. Singleton live births, delivered at 34-41 weeks to London-Middlesex mothers following spontaneous labour. Data were obtained from a city-wide perinatal database on births between 2002 and 2011 (n = 17,678). Multivariable analyses used multinomial logistic regression. The outcome of interest was the occurrence of late preterm (34-36 weeks) and early term (37-38 weeks) birth, compared with full term birth (39-41 weeks). After controlling for covariates, there were associations between infection and inflammation and late preterm birth (aOR = 2.07, 95% CI 1.65, 2.60); between placental ischaemia and other hypoxia and late preterm (aOR = 2.21, 95% CI 1.88, 2.61) and early term (aOR = 1.25, 95% CI 1.13, 1.39) birth; between diabetes mellitus and late preterm (aOR = 3.89, 95% CI 2.90, 5.21) and early term (aOR = 2.66, 95% CI 2.19, 3.23) birth; and between other biological determinants (polyhydramnios, oligohydramnios) and late preterm (aOR = 2.81, 95% CI 1.70, 4.64) and early term (aOR = 1.89, 95% CI 1.32, 2.70) birth. Our findings show that delivery following spontaneous labour even close to full term may be a result of pathological processes. Because these biological determinants of preterm birth contribute to an adverse intrauterine environment, they have important implications for fetal and neonatal health. © 2014 Royal College of Obstetricians and Gynaecologists.

  4. Introduction to Modern Methods in Light Microscopy.

    PubMed

    Ryan, Joel; Gerhold, Abby R; Boudreau, Vincent; Smith, Lydia; Maddox, Paul S

    2017-01-01

    For centuries, light microscopy has been a key method in biological research, from the early work of Robert Hooke describing biological organisms as cells, to the latest in live-cell and single-molecule systems. Here, we introduce some of the key concepts related to the development and implementation of modern microscopy techniques. We briefly discuss the basics of optics in the microscope, super-resolution imaging, quantitative image analysis, live-cell imaging, and provide an outlook on active research areas pertaining to light microscopy.

  5. London atmospheric Hydrogen and Carbon Monoxide: 12 year record, fluxes, and diurnal studies.

    NASA Astrophysics Data System (ADS)

    Lanoisellé, M.; Fisher, R. E.; Sriskantharajah, S.; Lowry, D.; Fowler, C. M. R.; Nisbet, E. G.

    2009-04-01

    declined rapidly in the period 1996-2003, but with less change since. Peaks in H2 and CO mixing ratio occur around the times of the morning and early evening rush hours and are thought to be predominantly from boiler emissions and vehicles. The winter H2:CO ratio during the morning rush hour period was 0.27 (DJF 2007-2008). In summer this ratio was lower: 0.19 (JJA 2007). Both H2 and CO mixing ratios usually decrease overnight. The dry deposition rate of H2 calculated by considering the overnight decline in H2 as 222Rn built up during anticyclonic conditions was 6.7 ± 3.6 x 10-4 m.s-1. Diurnal experiments allow characterisation of local sources in the West London region. dD of the H2 source has been investigated.

  6. Modern freshwater microbialite analogues for ancient dendritic reef structures

    NASA Technical Reports Server (NTRS)

    Laval, B.; Cady, S. L.; Pollack, J. C.; McKay, C. P.; Bird, J. S.; Grotzinger, J. P.; Ford, D. C.; Bohm, H. R.

    2000-01-01

    Microbialites are organosedimentary structures that can be constructed by a variety of metabolically distinct taxa. Consequently, microbialite structures abound in the fossil record, although the exact nature of the biogeochemical processes that produced them is often unknown. One such class of ancient calcareous structures, Epiphyton and Girvanella, appear in great abundance during the Early Cambrian. Together with Archeocyathids, stromatolites and thrombolites, they formed major Cambrian reef belts. To a large extent, Middle to Late Cambrian reefs are similar to Precambrian reefs, with the exception that the latter, including terminal Proterozoic reefs, do not contain Epiphyton or Girvanella. Here we report the discovery in Pavilion Lake, British Columbia, Canada, of a distinctive assemblage of freshwater calcite microbialites, some of which display microstructures similar to the fabrics displayed by Epiphyton and Girvanella. The morphologies of the modern microbialites vary with depth, and dendritic microstructures of the deep water (> 30 m) mounds indicate that they may be modern analogues for the ancient calcareous structures. These microbialites thus provide an opportunity to study the biogeochemical interactions that produce fabrics similar to those of some enigmatic Early Cambrian reef structures.

  7. The impact of private-sector provision on equitable utilisation of coronary revascularisation in London.

    PubMed

    Mindell, J; Klodawski, E; Fitzpatrick, J; Malhotra, N; McKee, M; Sanderson, C

    2008-08-01

    To investigate the impact of including private-sector data on assessments of equity of coronary revascularisation provision using NHS data only. Analyses of hospital episodes statistics and private-sector data by age, sex and primary care trust (PCT) of residence. For each PCT, the share of London's total population and revascularisations (all admissions, NHS-funded, and privately-funded admissions) were calculated. Gini coefficients were derived to provide an index of inequality across subpopulations, with parametric bootstrapping to estimate confidence intervals. London. London residents undergoing coronary revascularisation April 2001-December 2003. Coronary artery bypass graft or angioplasty. Directly standardised revascularisation rates, Gini coefficients. NHS-funded age-standardised revascularisation rates varied from 95.2 to 193.9 per 100,000 and privately funded procedures from 7.6 to 57.6. Although the age distribution did not vary by funding, the proportion of revascularisations among women that were privately funded (11.0%) was lower than among men (17.0%). Privately funded rates were highest in PCTs with the lowest death rates (p = 0.053). NHS-funded admission rates were not related to deprivation nor age-standardised deaths rates from coronary heart disease. Privately funded admission rates were lower in more deprived PCTs. NHS provision was significantly more egalitarian (Gini coefficient 0.12) than the private sector (0.35). Including all procedures was significantly less equal (0.13) than NHS-funded care alone. Private provision exacerbates geographical inequalities. Those responsible for commissioning care for defined populations must have access to consistent data on provision of treatment wherever it takes place.

  8. Time Resolved Resonance Raman Conference Royal Institution, London United Kingdom,

    DTIC Science & Technology

    1983-01-01

    Royal Institution, London U. K. Pell Laboratories 1 urray Hill, New Jersey 07974 S he purpose of the conference was to brinq together a group of...Pdman crosrsection. _ $ 1EELI- This dcunant has been eyptoved Lf ? p bli7: r:lease and sale; Us D I tibution is uAiAt. r - ., ~~- rw r- r -w-r 2. Raman...bacteriorhodopsin are closesly connected with the polyenes since the bacteriorhodopsin chro-ophose consists of a protonated shift base polyene. It is of interest to

  9. Peer Mentoring Experiences of Psychology Students at the London Metropolitan University Writing Centre

    ERIC Educational Resources Information Center

    Bakhshi, Savita; Harrington, Kathy; O'Neill, Peter

    2008-01-01

    "It really helps knowing that you are going to have someone around to help you..." This short article reports on research taking place into peer writing tutorials at London Metropolitan University and examines in particular, the experiences of psychology students who have taken part in the scheme. Some of the implications of this…

  10. Pioneers of Early Childhood Education: A Bio-Bibliographical Guide.

    ERIC Educational Resources Information Center

    Peltzman, Barbara Ruth

    Previous works on educators who built the field of early childhood education do not provide the researcher with primary and secondary sources or information on multicultural educators, nor do they discuss some of the more current leading educators. This reference book provides biographies and bibliographies of selected pre-modern and modern men…

  11. Martin Van Butchell (1735-1814): the eccentric, "kook" dentist of old London.

    PubMed

    Christen, A G; Christen, J A

    1999-11-01

    This article is a thumbnail sketch of the life and times of Martin Van Butchell (1735-1814), an eccentric, "kook" advertising dentist of Old London. Van Butchell earned these descriptive labels by displaying an unorthodox lifestyle, an outrageous personal appearance and outlandish, extreme and socially unacceptable personal and professional behaviors. While the general populace seemed to be fascinated by his strange ways, dentists and physicians were generally alienated by them. Nevertheless, he was considered a good dentist for his time, and he was extremely popular with his patients. Martin practiced dentistry for 23 years, and he practiced medicine as well, specializing in the treatment of ruptures and anal fistulas. Van Butchell interacted greatly with both John and William Hunter, who became two of the most famous and talented physicians, surgeons, anatomists and biologists of all time. When his first wife, Mary died, Martin arranged for her body to be embalmed and publicly displayed in his dental office for advertising purposes. Her preserved body was shown at the Museum of the Royal College of Surgeons (London), until it was destroyed by a German fire bomb in May, 1941. Mary's remains were on public display for a total of 166 years.

  12. A Modern Update and Usage of Historical Variable Star Catalogs

    NASA Astrophysics Data System (ADS)

    Pagnotta, Ashley; Graur, Or; Murray, Zachary; Kruk, Julia; Christie-Dervaux, Lucien; Chen, Dong Yi

    2015-01-01

    One of the earliest modern variable star catalogs was constructed by Henrietta Swan Leavitt during her tenure at the Harvard College Observatory (HCO) in the early 1900s. Originally published in 1908, Leavitt's catalog listed 1777 variables in the Magellanic Clouds (MCs). The construction and analysis of this catalog allowed her to subsequently discover the Cepheid period-luminosity relationship, now known as the Leavitt Law. The MC variable star catalogs were updated and expanded by Cecilia Payne-Gaposchkin in 1966 and 1971. Although newer studies of the MC variables have been performed since then, the new information has not always been correlated with the old due to a lack of modern descriptors of the stars listed in the Harvard MC catalogs. We will discuss the history of MC variable star catalogs, especially those compiled using the HCO plates, as well as our modernized version of the Leavitt and Payne-Gaposchkin catalogs. Our modern catalog can be used in conjunction with the archival plates (primarily via the Digital Access to a Sky Century @ Harvard scanning project) to study the secular behavior of the MC variable stars over the past century.

  13. RETHINKING THE ROLE OF SMALL-GROUP COLLABORATORS AND ADVERSARIES IN THE LONDON KLEINIAN DEVELOPMENT (1914-1968).

    PubMed

    Aguayo, Joseph; Regeczkey, Agnes

    2016-07-01

    The authors historically situate the London Kleinian development in terms of the small-group collaborations and adversaries that arose during the course of Melanie Klein's career. Some collaborations later became personally adversarial (e.g., those Klein had with Glover and Schmideberg); other adversarial relationships forever remained that way (with A. Freud); while still other long-term collaborations became theoretically contentious (such as with Winnicott and Heimann). After the Controversial Discussions in 1944, Klein marginalized one group of supporters (Heimann, Winnicott, and Riviere) in favor of another group (Rosenfeld, Segal, and Bion). After Klein's death in 1960, Bion maintained loyalty to Klein's ideas while quietly distancing his work from the London Klein group, immigrating to the United States in 1968. © 2016 The Psychoanalytic Quarterly, Inc.

  14. Deaths in childhood from cystic fibrosis: 10-year analysis from two London specialist centres.

    PubMed

    Urquhart, Donald S; Thia, Lena P; Francis, Jackie; Prasad, S Ammani; Dawson, Charlie; Wallis, Colin; Balfour-Lynn, Ian M

    2013-02-01

    Death in childhood from cystic fibrosis (CF) is now an uncommon event in the U.K. We wished to assess the circumstances surrounding deaths (and lung transplantation) in the modern era of CF care. A retrospective review was carried out pooling data from two large paediatric specialist CF units in London for the 10-year period 2000-2009 inclusive. There were 11 deaths and eight children who had a lung transplant out of 1022 children cared for in this period. Median age of death was 14.2 years and transplant 13.0 years, with a female preponderance (82% deaths and 75% transplants). Apart from one child (forced expiratory volume in 1 s (FEV1) 69%), lung function indicated severe lung disease (median FEV1 33%, range 12%-69%). Values 5 years prior to death were not predictive (median FEV1 62%, range 32%-96%), and those 1 year prior were similar to the last recorded levels. Almost all (10/11) died in hospital and 5/11 (45%) were ventilated. Respiratory failure was the commonest mode of death (64%). Only four children (36%) were receiving palliative care, and in six cases (55%) care was withdrawn. The number of deaths in children with CF was small but often unpredictable, so active management was continued until late in the majority, reflected by the fact that almost all were in hospital, and more than half were ventilated. If death from respiratory failure is anticipated following a steady decline, palliative care should be instituted well in advance, with attention to appropriate end of life care.

  15. History in the Early Nineteenth Century.

    PubMed

    Ratcliff, Jessica

    2016-09-01

    At the turn of the nineteenth century, at its headquarters in the City of London, the Honourable East India Company established a new museum and library. By midcentury this museum would contain one of Europe’s most extensive collections of the natural history, arts, and sciences of Asia. This essay uses the early history of the company’s museum, focusing in particular on its natural history collections, to explore the material relationship between scientific practice and the imperial political economy. Much of the collections had been gathered in the wake of military campaigns, trade missions, or administrative surveys. Once specimens and reports arrived in Leadenhall Street and passed through the museum storage areas, this plunder would become the stuff of science, going on to feed the growth of disciplines, societies, and projects in Britain and beyond. In this way, the East India Company was integral to the information and communication infrastructures within which many sciences then operated. Collections-based disciplines and societies flourished in this period; their growth, it is argued, was coextensive with administrative and political economic change at institutions like the East India Company. The essay first explores the company’s practices and patterns of collecting and then considers the consequences of this accumulation for aspects of scientific practice—particularly the growth of scientific societies—in both London and Calcutta.

  16. Evaluating Force-Field London Dispersion Coefficients Using the Exchange-Hole Dipole Moment Model.

    PubMed

    Mohebifar, Mohamad; Johnson, Erin R; Rowley, Christopher N

    2017-12-12

    London dispersion interactions play an integral role in materials science and biophysics. Force fields for atomistic molecular simulations typically represent dispersion interactions by the 12-6 Lennard-Jones potential using empirically determined parameters. These parameters are generally underdetermined, and there is no straightforward way to test if they are physically realistic. Alternatively, the exchange-hole dipole moment (XDM) model from density-functional theory predicts atomic and molecular London dispersion coefficients from first principles, providing an innovative strategy to validate the dispersion terms of molecular-mechanical force fields. In this work, the XDM model was used to obtain the London dispersion coefficients of 88 organic molecules relevant to biochemistry and pharmaceutical chemistry and the values compared with those derived from the Lennard-Jones parameters of the CGenFF, GAFF, OPLS, and Drude polarizable force fields. The molecular dispersion coefficients for the CGenFF, GAFF, and OPLS models are systematically higher than the XDM-calculated values by a factor of roughly 1.5, likely due to neglect of higher order dispersion terms and premature truncation of the dispersion-energy summation. The XDM dispersion coefficients span a large range for some molecular-mechanical atom types, suggesting an unrecognized source of error in force-field models, which assume that atoms of the same type have the same dispersion interactions. Agreement with the XDM dispersion coefficients is even poorer for the Drude polarizable force field. Popular water models were also examined, and TIP3P was found to have dispersion coefficients similar to the experimental and XDM references, although other models employ anomalously high values. Finally, XDM-derived dispersion coefficients were used to parametrize molecular-mechanical force fields for five liquids-benzene, toluene, cyclohexane, n-pentane, and n-hexane-which resulted in improved accuracy in the

  17. Why do general practitioners from France choose to work in London practices? A qualitative study.

    PubMed

    Ballard, Karen D; Robinson, Susan I; Laurence, Priscilla B

    2004-10-01

    Growing concerns about the ability to maintain and increase the general practitioner (GP) workforce has led to active recruitment of GPs from overseas. However, little is known about why these GPs choose to leave their countries and come to work in London. To investigate the motivations and expectations of French GPs migrating to work in general practices in London. A qualitative study using semi-structured interviews. General practice induction programme in southeast London. Individual interviews with 31 French GPs, who attended an induction programme for international recruits, were taped, transcribed, and analysed using a categorical approach. Three factors led to the process of migration: instigating factors, creating the stimulus for migration; activating factors, based on the perception that English general practice offered greater opportunities; and facilitating factors, which make migration possible. Particular emphasis was placed on personal and professional instigating factors, with a desire for new cultural experiences and a widespread discontent surrounding the infrastructure of French general practice, playing crucial roles in the stimulus to migrate. Ease of travel and a paid induction programme facilitated the move to their chosen destination. French GPs' decisions were part of a process of migration influenced by a series of integrated factors. Consideration of these factors will not only enhance recruitment to English general practice, but will also facilitate foreign GPs' transition to work in the National Health Service (NHS) and, ultimately, maximise their retention.

  18. Differences in body composition between infants of South Asian and European ancestry: the London Mother and Baby Study.

    PubMed

    Stanfield, Kristina M; Wells, Jonathan C; Fewtrell, Mary S; Frost, Chris; Leon, David A

    2012-10-01

    South Asian children and adults have a more adipose body composition compared with those of European ancestry. This is thought to be related to their increased risk of metabolic disorders. However, little is known about how early in life such differences are manifest. To determine whether there are differences in fat mass (FM) and fat-free mass (FFM) between UK-born South Asians and White Europeans in infancy. Design A cross-sectional study of 30 South Asian and 30 White European infants aged 6-12 weeks. Mothers were recruited from clinics in London, and infants' FM and FFM were determined using air-displacement plethysmography (PeaPod(®)). In early infancy South Asians had less FFM than White Europeans [0.34 kg less, 95% confidence interval (CI): 0.15, 0.52], with a considerably weaker indication of them also having more FM (0.02 kg more, 95% CI: -0.14, 0.18). These differences persisted when the overall smaller body size of South Asian infants was taken into account. For a given total infant weight, the balance of body composition of South Asians was shifted by 0.16 kg (95% CI: 0.06, 0.25) from FFM to FM. The ethnic differences in the amount of FFM were almost completely accounted for by ethnic differences in the rate of growth in utero and length of gestation. The characteristic differences in body composition observed between adult South Asians and White Europeans are apparent in early infancy. Of particular note is that this is the first study to demonstrate that South Asians compared with White Europeans have reduced FFM in infancy. The early manifestation of this phenotype suggests that it is either genetic and/or determined through exposure to maternal physiology, rather than a consequence of behaviours or diet in childhood or at older ages.

  19. Differences in body composition between infants of South Asian and European ancestry: the London Mother and Baby Study

    PubMed Central

    Stanfield, Kristina M; Wells, Jonathan C; Fewtrell, Mary S; Frost, Chris; Leon, David A

    2012-01-01

    Background South Asian children and adults have a more adipose body composition compared with those of European ancestry. This is thought to be related to their increased risk of metabolic disorders. However, little is known about how early in life such differences are manifest. Objective To determine whether there are differences in fat mass (FM) and fat-free mass (FFM) between UK-born South Asians and White Europeans in infancy. Design A cross-sectional study of 30 South Asian and 30 White European infants aged 6–12 weeks. Mothers were recruited from clinics in London, and infants’ FM and FFM were determined using air-displacement plethysmography (PeaPod®). Results In early infancy South Asians had less FFM than White Europeans [0.34 kg less, 95% confidence interval (CI): 0.15, 0.52], with a considerably weaker indication of them also having more FM (0.02 kg more, 95% CI: −0.14, 0.18). These differences persisted when the overall smaller body size of South Asian infants was taken into account. For a given total infant weight, the balance of body composition of South Asians was shifted by 0.16 kg (95% CI: 0.06, 0.25) from FFM to FM. The ethnic differences in the amount of FFM were almost completely accounted for by ethnic differences in the rate of growth in utero and length of gestation. Conclusions The characteristic differences in body composition observed between adult South Asians and White Europeans are apparent in early infancy. Of particular note is that this is the first study to demonstrate that South Asians compared with White Europeans have reduced FFM in infancy. The early manifestation of this phenotype suggests that it is either genetic and/or determined through exposure to maternal physiology, rather than a consequence of behaviours or diet in childhood or at older ages. PMID:22984147

  20. Has the London 2012 Olympic Inspire Programme Inspired a Generation? A Realist View

    ERIC Educational Resources Information Center

    Girginov, Vassil

    2016-01-01

    The organisers of the 2012 London Olympics have endeavoured explicitly to use the Games to inspire a generation. This is nothing short of putting the main claim of Olympism to the test, but surprisingly the Inspire project has received virtually no scholarly scrutiny. Using an educationally-informed view of inspiration, this paper interrogates the…