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Sample records for early tertiary laramide

  1. Tertiary tilting and dismemberment of the laramide arc and related hydrothermal systems, Sierrita Mountain, Arizona

    Stavast, W.J.A.; Butler, R.P.; Seedorff, E.; Barton, M.D.; Ferguson, C.A.

    2008-01-01

    Multiple lines of evidence, including new and published geologic mapping and paleomagnetic and geobarometric determinations, demonstrate that the rocks and large porphyry copper systems of the Sierrita Mountains in southern Arizona were dismembered and tilted 50?? to 60?? to the south by Tertiary normal faulting. Repetition of geologic features and geobarometry indicate that the area is segmented into at least three major structural blocks, and the present surface corresponds to oblique sections through the Laramide plutonic-hydrothermal complex, ranging in paleodepth from ???1 to ???12 km. These results add to an evolving view of a north-south extensional domain at high angles to much extension in the southern Basin and Range, contrast with earlier interpretations that the Laramide systems are largely upright and dismembered by thrust faults, highlight the necessity of restoring Tertiary rotations before interpreting Laramide structural and hydrothermal features, and add to the broader understanding of pluton emplacement and evolution of porphyry copper systems. ?? 2008 Society of Economic Geologists, Inc.

  2. Early Tertiary Anaconda metamorphic core complex, southwestern Montana

    O'Neill, J. M.; Lonn, J.D.; Lageson, D.R.; Kunk, Michael J.

    2004-01-01

    A sinuous zone of gently southeast-dipping low-angle Tertiary normal faults is exposed for 100 km along the eastern margins of the Anaconda and Flint Creek ranges in southwest Montana. Faults in the zone variously place Mesoproterozoic through Paleozoic sedimentary rocks on younger Tertiary granitic rocks or on sedimentary rocks older than the overlying detached rocks. Lower plate rocks are lineated and mylonitic at the main fault and, below the mylonitic front, are cut by mylonitic mesoscopic to microscopic shear zones. The upper plate consists of an imbricate stack of younger-on-older sedimentary rocks that are locally mylonitic at the main, lowermost detachment fault but are characteristically strongly brecciated or broken. Kinematic indicators in the lineated mylonite indicate tectonic transport to the east-southeast. Syntectonic sedimentary breccia and coarse conglomerate derived solely from upper plate rocks were deposited locally on top of hanging-wall rocks in low-lying areas between fault blocks and breccia zones. Muscovite occurs locally as mica fish in mylonitic quartzites at or near the main detachment. The 40Ar/39Ar age spectrum obtained from muscovite in one mylonitic quartzite yielded an age of 47.2 + 0.14 Ma, interpreted to be the age of mylonitization. The fault zone is interpreted as a detachment fault that bounds a metamorphic core complex, here termed the Anaconda metamorphic core complex, similar in age and character to the Bitterroot mylonite that bounds the Bitterroot metamorphic core complex along the Idaho-Montana state line 100 km to the west. The Bitterroot and Anaconda core complexes are likely components of a continuous, tectonically integrated system. Recognition of this core complex expands the region of known early Tertiary brittle-ductile crustal extension eastward into areas of profound Late Cretaceous contractile deformation characterized by complex structural interactions between the overthrust belt and Laramide basement uplifts

  3. The Colorado front range: anatomy of a Laramide uplift

    Kellogg, Karl; Bryant, Bruce; Reed, John C.

    2004-01-01

    Along a transect across the Front Range from Denver to the Blue River valley near Dillon, the trip explores the geologic framework and Laramide (Late Cretaceous to early Eocene) uplift history of this basement-cored mountain range. Specific items for discussion at various stops are (1) the sedimentary and structural record along the upturned eastern margin of the range, which contains several discontinuous, east-directed reverse faults; (2) the western structural margin of the range, which contains a minimum of 9 km of thrust overhang and is significantly different in structural style from the eastern margin; (3) mid- to late-Tertiary modifications to the western margin of the range from extensional faulting along the northern Rio Grande rift trend; (4) the thermal and uplift history of the range as revealed by apatite fission track analysis; (5) the Proterozoic basement of the range, including the significance of northeast-trending shear zones; and (6) the geologic setting of the Colorado mineral belt, formed during Laramide and mid-Tertiary igneous activity.

  4. Detrital record of initial basement exhumation along the Laramide deformation front, southern Rocky Mountains

    NASA Astrophysics Data System (ADS)

    Bush, Meredith A.; Horton, Brian K.; Murphy, Michael A.; Stockli, Daniel F.

    2016-09-01

    New geochronological constraints on upper crustal exhumation in the southern Rocky Mountains help delineate the latest Cretaceous-Paleogene history of drainage reorganization and landscape evolution during Laramide flat-slab subduction beneath western North America. Detrital zircon U-Pb results for the Raton basin of southern Colorado and northern New Mexico define the inception of coarse-grained siliciclastic sedimentation and a distinctive shift in provenance, from distal to proximal sources, that recorded shortening-related uplift and unroofing along the Laramide deformation front of the northern Sangre de Cristo Mountains. This Maastrichtian-early Paleocene ( 70-65 Ma) change—from distal foreland accumulation of sediment derived from the thin-skinned Cordilleran (Sevier) fold-thrust belt to coarse-grained sedimentation proximal to a Laramide basement block uplift—reflects cratonward (eastward) deformation advance and reorganization of drainage systems that supplied a large volume of Paleocene-lower Eocene sediments to the Gulf of Mexico. The timing of unroofing along the eastern deformation front is synchronous with basement-involved shortening across the interior of the Laramide province, suggesting abrupt wholesale uplift rather than a systematic inboard advance of deformation. The growth and infilling of broken foreland basins within the interior and margins of the Laramide province had a significant impact on continental-scale drainage systems, as several ponded/axial Laramide basins trapped large volumes of sediment and induced reorganization of major source-to-sink sediment pathways.

  5. Laramide alteration of proterozoic diabase: A likely contributor of copper to porphyry systems in the dripping spring mountains area, Southeastern Arizona

    Force, E.R.

    1998-01-01

    Proterozoic diabase of the Dripping Spring range occurs as sills in the Proterozoic Apache Group and the Troy Quartzite and as intrusive sheets in basement rocks. The aggregate thickness of the diabase sills and intrusive sheets averages about 450 m in the part of the range showing little mid-Tertiary extension. Laramide alteration is of two types, dominated by chlorite and actinolite, respectively, and formed mostly from clinopyroxene. Actinolite-dominated assemblages are higher in Na and Ca. Hydrothermal biotite is common in the central areas of both alteration types. Laramide alteration forms two distribution patterns: a subequant pattern centered on Laramide intrusions and small porphyry deposits, characterized by actinolitic alteration, and a more extensive branching linear pattern that follows Laramide structures, centered on the larger Ray porphyry deposit, extending toward other Laramide districts and showing both alteration types. Alteration has apparently mobilized copper and other metals from diabase. The freshest diabase samples average about 120 ppm copper with little variation. In chloritic alteration, about 100 ppm of this copper is expelled in the most completely altered rocks. In actinolitic alteration, diabase may either gain or lose copper during alteration. Chloritic alteration constitutes roughly 70 percent of the diabase alteration in the study area, where alteration averages 41 percent complete. This implies liberation of about 9 ?? 106 tons (t) copper from diabase alteration, significantly less than the 16 ?? 106 t copper in Laramide mineral deposits of the superdistrict (Ray, Superior, Chilito, Christmas). However, diabase alteration may have been a significant component of the supply of copper to the Laramide mineral districts of the area. Synmineral magmatic sources of copper are not documented in this area. The distribution of Proterozoic diabase coincides with the central part of the southeastern Arizona copper province, which may thus

  6. Deformation in the mantle wedge associated with Laramide flat-slab subduction

    NASA Astrophysics Data System (ADS)

    Behr, W. M.; Smith, D.

    2013-12-01

    Early Tertiary crustal deformation preserved ~1500 km from the plate boundary in the western U.S. is considered by most to be related to a narrow segment of shallow Farallon-slab subduction, similar to the modern Pampean flat-slab of the central Andes. Evidence that the slab shallowed enough to penetrate several hundred kilometers inboard of the plate boundary includes a) shearing off of lithosphere and underplating of schists derived from the accretionary wedge beneath the volcanic arc; b) a cessation of arc magmatism and eastward sweeping of the magmatic front; and c) mid-Tertiary eruptions as far east as the Four Corners region of serpentinized ultramafic microbreccia (SUM) sourced from very cold, hydrated mantle lithosphere. Included within the SUM diatremes are eclogites interpreted to represent fragments of the slab itself and/or remnants of older rock from the mantle wedge metasomatized and recrystallized to eclogite along the top of the slab. Also included within the SUM diatremes are deformed peridotites that represent pieces of the variably hydrated mantle wedge as well as tectonically eroded and entrained fragments of the plate interface. These include weakly deformed to strongly foliated tectonites, spectacularly sheared mylonites and ultramylonites, and cataclasites, formed at temperatures ranging from 500-650°C. Some of the deformed samples contain hydrous minerals, including antigorite, chlorite, and/or tremolite/pargasite that were formed in-situ prior to or during deformation. We investigate the rheological and seismic properties of the peridotite samples using detailed microstructural and petrological analyses. Initial EBSD data indicate that an antigorite-bearing mylonite exhibits a B-type olivine LPO, whereas an ultramylonite that lacks hydrous minerals exhibits an A-type olivine LPO. This is consistent with experimental data that indicate B-type LPOs form under hydrous conditions; and it suggests that these rocks record a transition from

  7. Basement and cover-rock deformation during Laramide contraction in the northern Madison Range (Montana) and its influence on Cenozoic basin formation

    Kellogg, K.S.; Schmidt, C.J.; Young, S.W.

    1995-01-01

    Two major Laramide fault systems converge in the northwestern Madison Range: the northwest-striking, southwest-vergent Spanish Peaks reverse fault and the north-striking, east-vergent Hilgard thrust system. Analysis of foliation attitudes in basement gneiss north and south of the Spanish Peaks fault indicates that the basement in thrusted blocks of the Hilgard thrust system have been rotated by an amount similar to that of the basement-cover contact. Steeply dipping, north-striking breccia zones enclosing domains of relatively undeformed basement may have permitted domino-style rotation of basement blocks during simple shear between pairs of thrusts. No hydrocarbon discoveries have been made in this unique structural province. However, petroleum exploration here has focused on basement-cored anticlines, both surface and subthrust, related to the two major Laramide fault systems and on the fault-bounded blocks of Tertiary rocks within the post-Laramide extensional basins. -from Authors

  8. Rise and Demise of a Southern Laramide Hinterland Plateau, US-Mexico Border Region

    NASA Astrophysics Data System (ADS)

    Lawton, T. F.; Clinkscales, C. A.; Jennings, G. R.

    2011-12-01

    -west normal faults are occupied by regionally widespread granitic and rhyolitic dikes ranging 34-27 Ma, yet the Oligocene volcaniclastic rocks are cut by the faults, indicating that the fault system was active during earliest-early late Oligocene magmatism. From the newly assembled data, we infer the presence of a high-standing plateau along the US-Mexico border that was backed by a magmatic arc in northern Mexico. The plateau was supported by lithosphere thickened during backarc contraction, which began in the interval 97-75 Ma. Although the depositional elevation of the Laramide lakes is not yet known, rivers flowed northward from the hinterland plateau toward the Uinta Basin as early as 80 Ma and corroborate the existence of a southern source area. The plateau was thus a long-lived feature with a longevity of as much as 40-50 m.y. It collapsed during Paleogene N-S extension triggered by some combination of thermal weakening by Oligocene magmatism, gravitational failure, and/or retrograde motion of the Farallon slab. The southern Laramide plateau was evidently linked both geographically and temporally to the Cordilleran hinterland plateau ("Nevadaplano") of Nevada and western Utah and thus constituted an important component of the greater Laramide orogen.

  9. Cool episodes in Early Tertiary Arctic climate: Evidence from Svalbard

    NASA Astrophysics Data System (ADS)

    Spielhagen, R. F.; Tripati, A.

    2009-04-01

    The Arctic is a climatically sensitive and important region. However, very little is known about the climatic and oceanographic evolution of the area, particularly prior to the Neogene. Until recently, the Arctic was assumed to be characterized by relatively warm conditions during the early Cenozoic. The Early Tertiary sedimentary sequence on Svalbard contains several layers with coal seams and broad-leaved plants which were commonly accepted as indicators of a generally temperate-warm climate. Here we report on the intermittent occurrence of certain temperature indicators in the succession, which may represent the first northern high-latitude record of near-freezing temperatures for the early Cenozoic. Besides the findings of probably ice-rafted erratic clasts in the Paleocene and Eocene sandstones and shales, we note especially the occurrence of glendonites which are pseudomorphs of calcite after ikaite (calcium carbonate hexahydrate). We measured the chemical composition of Svalbard glendonites which is almost identical to that of similar pseudomorphs from the Lower Cretaceaous of Northern Canada. Mass spectrometric analyses of the glendonite calcite gave very low carbon isotope values. These values suggest a provenance of the calcium carbonate from marine organic carbon and connect our glendonites to the precursor mineral ikaite which has similar low values. Since a variety of studies has demonstrated that ikaite is stable only at temperatures close to freezing point, we have to infer low temperatures also for the deepositional environment of which the sediments were deposited that now hold glendonites. These results imply the occurrence of cooling phases episodically during the warm background climate of the Paleocene and Eocene, suggesting that temperature variability was much greater than previously recognized.

  10. Geologic signature of early Tertiary ridge subduction in Alaska

    Bradley, Dwight C.; Kusky, Timothy M.; Haeussler, Peter J.; Goldfarb, Richard J.; Miller, Marti L.; Dumoulin, Julie A.; Nelson, Steven W.; Karl, Susan M.

    2003-01-01

    ridge subduction, and changes in the strength of the prism as it was heated and then cooled. In this model, events in the Alaskan interior would have taken place above more distal, deeper parts of the slab window. Extensional (or transtensional) basin subsidence was driven by the two subducting plates that each exerted different tractions on the upper plate. The magmatic lull along the arc presumably marks a time when hydrated lithosphere was not being subducted beneath the arc axis. The absence of a subducting slab also may explain uplift of the Brooks Range and North Slope: Geodynamic models predict that longwavelength uplift of this magnitude will take place far inboard from Andean-type margins when a subducting slab is absent. Precise correlations between events in the accretionary prism and the Alaskan interior are hampered, however, by palinspastic problems. During and since the early Tertiary, margin-parallel strike-slip faulting has offset the near-trench plutonic belt - i.e., the very basis for locating the triple junction and slab window - from its backstop, by an amount that remains controversial.Near-trench magmatism began at 61 Ma at Sanak Island in the west but not until 51 Ma at Baranof Island, 2200 km to the east. A west-to-east age progression suggests migration of a trench-ridge-trench triple junction, which we term the Sanak-Baranof triple junction. Most workers have held that the subducted ridge separated the Kula and Farallon plates. As a possible alternative, we suggest that the ridge may have separated the Kula plate from another oceanic plate to the east, which we have termed the Resurrection plate.

  11. Post-Laramide Epiorogeny through Crustal Hydration?

    NASA Astrophysics Data System (ADS)

    Jones, C. H.; Mahan, K. H.; Farmer, G.

    2011-12-01

    hydration has also been described from xenoliths in the Four Corners region of the Colorado Plateau (Broadhurst, 1986; Selverstone et al., 1999). The presence of a partially hydrated high-wavespeed layer at the base of the crust could complicate attempts to define the Moho using receiver functions, a problem encountered in several areas in Wyoming and the Colorado Plateau.The timing of the observed lower crustal hydration is unknown, but if related to Cenozoic uplift this implies that fluids were added in Late Cretaceous to Early Tertiary, potentially via dehydration of shallowly subducting oceanic lithosphere. If correct, this idea requires some means of passing significant amounts of fluid to the lower crust through the lithospheric mantle.

  12. Heating, cooling, and uplift during Tertiary time, northern Sangre de Cristo Range, Colorado ( USA).

    Lindsay, D.A.; Andriessen, P.A.M.; Wardlaw, B.R.

    1986-01-01

    Paleozoic sedimentary rocks in a wide area of the northern Sangre de Cristo Range show effects of heating during Tertiary time. Heating is tentatively interpreted as a response to burial during Laramide folding and thrusting and also to high heat flow during Rio Grande rifting. Fission-track ages of apatite across a section of the range show that rocks cooled abruptly below 120oC, the blocking temperature for apatite, approx 19 Ma ago. Cooling was probably in response to rapid uplift and erosion of the northern Sangre de Cristo Range during early Rio Grande rifting.-from Authors

  13. Laramide basin CSI: Comprehensive stratigraphic investigations of Paleogene sediments in the Colorado Headwaters Basin, north-central Colorado

    Dechesne, Marieke; Cole, James Channing; Trexler, James H.; Cashman, Patricia; Peterson, Christopher D

    2013-01-01

    The Paleogene sedimentary deposits of the Colorado Headwaters Basin provide a detailed proxy record of regional deformation and basin subsidence during the Laramide orogeny in north-central Colorado and southern Wyoming. This field trip presents extensive evidence from sedimentology, stratigraphy, structure, palynology, and isotope geochronology that shows a complex history that is markedly different from other Laramide synorogenic basins in the vicinity.We show that the basin area was deformed by faulting and folding before, during, and after deposition of the Paleogene rocks. Internal unconformities have been identified that further reflect the interaction of deformation, subsidence, and sedimentation. Uplift of Proterozoic basement blocks that make up the surrounding mountain ranges today occurred late in basin history. Evidence is given to reinterpret the Independence Mountain uplift as the result of significant normal faulting (not thrusting), probably in middle Tertiary time.While the Denver and Cheyenne Basins to the east were subsiding and accumulating sediment during Late Cretaceous time, the Colorado Headwaters Basin region was experiencing vertical uplift and erosion. At least 1200 m of the upper part of the marine Upper Cretaceous Pierre Shale was regionally removed, along with Fox Hills Sandstone shoreline deposits of the receding Interior Seaway as well as any Laramie Formation–type continental deposits. Subsidence did not begin in the Colorado Headwaters Basin until after 60.5 Ma, when coarse, chaotic, debris-flow deposits of the Paleocene Windy Gap Volcanic Member of the Middle Park Formation began to accumulate along the southern basin margin. These volcaniclastic conglomerate deposits were derived from local, mafic-alkalic volcanic sources (and transitory deposits in the drainage basin), and were rapidly transported into a deep lake system by sediment gravity currents. The southern part of the basin subsided rapidly (roughly 750–1000 m

  14. Laramide structure of the central Sangre de Cristo Mountains and adjacent Raton Basin, southern Colorado

    Lindsey, D.A.

    1998-01-01

    Laramide structure of the central Sangre de Cristo Mountains (Culebra Range) is interpreted as a system of west-dipping, basement-involved thrusts and reverse faults. The Culebra thrust is the dominant structure in the central part of the range; it dips 30 -55?? west and brings Precambrian metamorphic base-ment rocks over unmetamorphosed Paleozoic rocks. East of the Culebra thrust, thrusts and reverse faults break the basement and overlying cover rocks into north-trending fault blocks; these boundary faults probably dip 40-60?? westward. The orientation of fault slickensides indicates oblique (northeast) slip on the Culebra thrust and dip-slip (ranging from eastward to northward) movement on adjacent faults. In sedimentary cover rocks, east-vergent anticlines overlie and merge with thrusts and reverse faults; these anticlines are interpreted as fault-propagation folds. Minor east-dipping thrusts and reverse faults (backthrusts) occur in both the hanging walls and footwalls of thrusts. The easternmost faults and folds of the Culebra Range form a continuous structural boundary between the Laramide Sangre de Cristo highland and the Raton Basin. Boundary structures consist of west-dipping frontal thrusts flanked on the basinward side by poorly exposed, east-dipping backthrusts. The backthrusts are interpreted to overlie structural wedges that have been emplaced above blind thrusts in the basin margin. West-dipping frontal thrusts and blind thrusts are interpreted to involve basement, but backthrusts are rooted in basin-margin cover rocks. At shallow structural levels where erosion has not exposed a frontal thrust, the structural boundary of the basin is represented by an anticline or monocline. Based on both regional and local stratigraphic evidence, Laramide deformation in the Culebra Range and accompanying synorogenic sedimentation in the western Raton Basin probably took place from latest Cretaceous through early Eocene time. The earliest evidence of uplift and

  15. Early Tertiary transtension-related deformation and magmatism along the Tintina fault system, Alaska

    Till, A.B.; Roeske, S.M.; Bradley, D.C.; Friedman, R.; Layer, P.W.

    2007-01-01

    Transtensional deformation was concentrated in a zone adjacent to the Tintina strike-slip fault system in Alaska during the early Tertiary. The deformation occurred along the Victoria Creek fault, the trace of the Tintina system that connects it with the Kaltag fault; together the Tintina and Kaltag fault systems girdle Alaska from east to west. Over an area of ???25 by 70 km between the Victoria Creek and Tozitna faults, bimodal volcanics erupted; lacustrine and fluvial rocks were deposited; plutons were emplaced and deformed; and metamorphic rocks cooled, all at about the same time. Plutonic and volcanic rocks in this zone yield U-Pb zircon ages of ca. 60 Ma; 40Ar/ 39Ar cooling ages from those plutons and adjacent metamorphic rocks are also ca. 60 Ma. Although early Tertiary magmatism occurred over a broad area in central Alaska, meta- morphism and ductile deformation accompanied that magmatism in this one zone only. Within the zone of deformation, pluton aureoles and metamorphic rocks display consistent NE-SW-stretching lineations parallel to the Victoria Creek fault, suggesting that deformation processes involved subhorizontal elongation of the package. The most deeply buried metamorphic rocks, kyanite-bearing metapelites, occur as lenses adjacent to the fault, which cuts the crust to the Moho (Beaudoin et al., 1997). Geochronologic data and field relationships suggest that the amount of early Tertiary exhumation was greatest adjacent to the Victoria Creek fault. The early Tertiary crustal-scale events that may have operated to produce transtension in this area are (1) increased heat flux and related bimodal within-plate magmatism, (2) movement on a releasing stepover within the Tintina fault system or on a regional scale involving both the Tintina and the Kobuk fault systems, and (3) oroclinal bending of the Tintina-Kaltag fault system with counterclockwise rotation of western Alaska. ?? 2007 The Geological Society of America. All rights reserved.

  16. Feast to famine: Sediment supply control on Laramide basin fill

    NASA Astrophysics Data System (ADS)

    Carroll, Alan R.; Chetel, Lauren M.; Elliot Smith, M.

    2006-03-01

    Erosion of Laramide-style uplifts in the western United States exerted an important first-order influence on Paleogene sedimentation by controlling sediment supply rates to adjacent closed basins. During the latest Cretaceous through Paleocene, these uplifts exposed thick intervals of mud-rich Upper Cretaceous foreland basin fill, which was quickly eroded and redeposited. Cretaceous sedimentary lithologies dominate Paleocene conglomerate clast compositions, and the volume of eroded foreland basin strata is approximately twice the volume of preserved Paleocene basin fill. As a result of this sediment oversupply, clastic alluvial and paludal facies dominate Paleocene strata, and are associated with relatively shallow and ephemeral freshwater lake facies. In contrast, large, long-lived, carbonate-producing lakes occupied several of the basins during the Eocene. Basement-derived clasts (granite, quartzite, and other metamorphic rocks) simultaneously became abundant in lower Eocene conglomerate. We propose that Eocene lakes developed primarily due to exposure of erosion-resistant lithologies within cores of Laramide uplifts. The resultant decrease in erosion rate starved adjacent basins of sediment, allowing the widespread and prolonged deposition of organic-rich lacustrine mudstone. These observations suggest that geomorphic evolution of the surrounding landscape should be considered as a potentially important influence on sedimentation in many other interior basins, in addition to more conventionally interpreted tectonic and climatic controls.

  17. Mechanisms for creating accommodation space during early Tertiary sedimentation in Tibet.

    NASA Astrophysics Data System (ADS)

    Studnicki-Gizbert, C.; Burchfiel, B. C.

    2003-12-01

    The Tibetan plateau is for the most part underlain by rocks of pre-Cenozoic age, a fact that has hindered the identification of Cenozoic shortening structures that can be unequivocally related to the effects of India-Asia collision. Notably, however, the Qiangtang block contains a number of small, short wavelength basins filled with terrestrial sediments of early Tertiary age. Where these basins have been well studied, sedimentation is recognized as having occurred coevally with compressional deformation. The classic treatment of compressional basins appeals to accommodation space created by the flexure of an elastic plate in response to loads created by adjacent thrust fault bound ranges. It is unlikely that the Tertiary basins of the Qiangtang block formed in this manner. The wavelength of a classically modelled flexural basin is a basically a function of the thickness of the elastic plate and the density difference between sedimentary fill and ductile material underlying the plate. Assuming a model of elastic flexure, the very small wavelengths (5 - 30km) characteristic of Qiangtang basins would then imply extremely thin (~ 1-5 km) effective elastic plate thicknesses. These very low values are difficult to reconcile with any reasonable characterization of crustal rheology. Instead, these relatively small basins likely record the creation of accommodation space created by differential uplift across the strike of folds and faults. Stratal geometries and sedimentation rates reflect the kinematics and geometries of local compressional structures and the mechanical basis for the creation of accommodation space remains uncertain. Finally, the origin of these basins makes it unlikely that early Tertiary sedimentation represents a significant fraction of the upper crust of Tibetan plateau.

  18. Tertiary evolution of the Shimanto belt (Japan): A large-scale collision in Early Miocene

    NASA Astrophysics Data System (ADS)

    Raimbourg, Hugues; Famin, Vincent; Palazzin, Giulia; Yamaguchi, Asuka; Augier, Romain

    2017-07-01

    To decipher the Miocene evolution of the Shimanto belt of southwestern Japan, structural and paleothermal studies were carried out in the western area of Shikoku Island. All units constituting the belt, both in its Cretaceous and Tertiary domains, are in average strongly dipping to the NW or SE, while shortening directions deduced from fault kinematics are consistently orientated NNW-SSE. Peak paleotemperatures estimated with Raman spectra of organic matter increase strongly across the southern, Tertiary portion of the belt, in tandem with the development of a steeply dipping metamorphic cleavage. Near the southern tip of Ashizuri Peninsula, the unconformity between accreted strata and fore-arc basin, present along the whole belt, corresponds to a large paleotemperature gap, supporting the occurrence of a major collision in Early Miocene. This tectonic event occurred before the magmatic event that affected the whole belt at 15 Ma. The associated shortening was accommodated in two opposite modes, either localized on regional-scale faults such as the Nobeoka Tectonic Line in Kyushu or distributed through the whole belt as in Shikoku. The reappraisal of this collision leads to reinterpret large-scale seismic refraction profiles of the margins, where the unit underlying the modern accretionary prism is now attributed to an older package of deformed and accreted sedimentary units belonging to the Shimanto belt. When integrated into reconstructions of Philippine Sea Plate motion, the collision corresponds to the oblique collision of a paleo Izu-Bonin-Mariana Arc with Japan in Early Miocene.

  19. Precious metals associated with Late Cretaceous-early Tertiary igneous rocks of southwestern Alaska

    Bundtzen, Thomas K.; Miller, Marti L.; Goldfarb, Richard J.; Miller, Lance D.

    1997-01-01

    Placer gold and precious metal-bearing lode deposits of southwestern Alaska lie within a region 550 by 350 km, herein referred to as the Kuskokwim mineral belt. This mineral belt has yielded 100,240 kg (3.22 Moz) of gold, 12, 813 kg (412,000 oz) of silver, 1,377,412 kg (39,960 flasks) of mercury, and modest amounts of antimony and tungsten derived primarily from the late Cretaceous-early Tertiary igneous complexes of four major types: (1) alkali-calcic, comagmatic volcanic-plutonic complexes and isolated plutons, (2) calc-alkaline, meta-aluminous reduced plutons, (3) peraluminous alaskite or granite-porphyry sills and dike swarms, and (4) andesite-rhyolite subaerial volcanic rocks.About 80 percent of the 77 to 52 Ma intrusive and volcanic rocks intrude or overlie the middle to Upper Cretaceous Kuskokwim Group sedimentary and volcanic rocks, as well as the Paleozoic-Mesozoic rocks of the Nixon Fork, Innoko, Goodnews, and Ruby preaccretionary terranes.The major precious metal-bearing deposit types related to Late Cretaceous-early Tertiary igneous complexes of the Kuskokwim mineral belt are subdivided as follows: (1) plutonic-hosted copper-gold polymetallic stockwork, skarn, and vein deposits, (2) peraluminous granite-porphory-hosted gold polymetallic deposits, (3) plutonic-related, boron-enriched silver-tin polymetallic breccia pipes and replacement deposits, (4) gold and silver mineralization in epithermal systems, and (5) gold polymetallic heavy mineral placer deposits. Ten deposits genetically related to Late Cretaceous-early Tertiary intrusions contain minimum, inferred reserves amounting to 162,572 kg (5.23 Moz) of gold, 201,015 kg (6.46 Moz) silver, 12,160 metric tons (t) of tin, and 28,088 t of copper.The lodes occur in veins, stockworks, breccia pipes, and replacement deposits that formed in epithermal to mesothermal temperature-pressure conditions. Fluid inclusion, isotopic age, mineral assemblage, alteration assemblage, and structural data indicate that

  20. Chemical Properties, Decomposition, and Methane Production of Tertiary Relict Plant Litters: Implications for Atmospheric Trace Gas Production in the Early Tertiary

    NASA Astrophysics Data System (ADS)

    Yavitt, J. B.; Bartella, T. M.; Williams, C. J.

    2006-12-01

    Throughout the early Tertiary (ca. 65-38 Ma) Taxodiaceae-dominated (redwood) wetland forests occupied the high latitudes and were circumpolar in their distribution. Many of these forests had high standing biomass with moderate primary productivity. The geographic extent and amount of Tertiary coals and fossil forests throughout Arctic Canada suggests large areas of wetland forests that may have cycled substantial quantities of carbon, particularly methane until they were replaced by cold tolerant Pinus, Picea, and Larix following climatic cooling associated with the Terminal Eocene Event. To test this hypothesis we compared physiochemical properties, decomposition, and trace gas production of litter from extant Metasequoia, Pinus, Picea, and Larix. Initial results from plantation-grown trees indicate Metasequoia litter is a better source of labile organic substrate than pinaceous litter. Metasequoia litter contained the least lignin and highest amounts of water-soluble compounds of the four litter types studied. Analysis of the lignin structure using cupric oxide oxidation indicates that Metasequoia lignin is enriched in 4'-hydroxyacetophenone and 4'- Hydroxy-3'-methoxyacetophenone relative to the pinaceous litter. In a 12-month decomposition study using litterbags, average litter mass loss was greater for Metasequoia litter (62%) compared to the pinaceous species (50%). Moreover, Metasequoia litter incubated under anoxic conditions produced nearly twice as much CO2 (ca. 4.2 umol/g.day) and CH4 (2.1 umol/g.day) as the pinaceous litter (2.4 umol/g.day for CO2; 1.2 umol/g.day for CH4). Our results support the idea of greater decomposability and palatability of Metasequoia litter as compared to Larix, Picea, or Pinus. Provided that the biochemical properties of Metasequoia have remained relatively stable through geologic time, it appears that early Tertiary Metasequoia-dominated wetland forests may have had higher microbial driven trace gas production than the

  1. The Wandering Indian Plate and Its Changing Biogeography During the Late Cretaceous-Early Tertiary Period

    NASA Astrophysics Data System (ADS)

    Chatterjee, Sankar; Scotese, Christopher

    Palaeobiogeographic analysis of Indian tetrapods during the Late Cretaceous-Early Tertiary time has recognized that both vicariance and geodispersal have played important roles in producing biogeographic congruence. The biogeographic patterns show oscillating cycles of geodispersal (Late Cretaceous), followed by congruent episodes of vicariance and geodispersal (Early Eocene), followed by another geodispersal event (Middle Eocene). New biogeographic synthesis suggests that the Late Cretaceous Indian tetrapod fauna is cosmopolitan with both Gondwanan and Laurasian elements. Throughout most of the Cretaceous, India was separated from the rest of Gondwana, but in the latest Cretaceous it reestablished contact with Africa through Kohistan-Dras (K-D) volcanic arc, and maintained biotic link with South America via Ninetyeast Ridge-Kerguelen-Antarctica corridor. These two geodispersal routes allowed exchanges of "pan-Gondwana" terrestrial tetrapods from Africa, South America, and Madagascar. During that time India also maintained biotic connections with Laurasia across the Neotethys via Kohistan-Dras Arc and Africa. During the Palaeocene, India, welded to the K-D Arc, rafted like a "Noah's Ark" as an island continent and underwent rapid cladogenesis because of allopatric speciation. Although the Palaeocene fossil record is blank, Early Eocene tetrapods contain both endemic and cosmopolitan elements, but Middle Eocene faunas have strong Asian character. India collided with Asia in Early and Middle Eocene time and established a new northeast corridor for faunal migration to facilitate the bidirectional "Great Asian Interchange" dispersals.

  2. Extent and character of early tertiary penetrative deformation, Sonora, Northwest Mexico

    NASA Technical Reports Server (NTRS)

    Anderson, T. H.

    1985-01-01

    Reconnaissance field work has led to the recognition of extensive Early Tertiary gneiss and schist which are distinguished by weakly developed to highly conspicous northeast to east-trending stretching lineation commonly accompanied by low-dipping foliation. This structural fabric has been imposed on Precambrian to Paleogene rocks. Regionally, minimum ages of deformation are based upon interpreted U-Pb isotopic ages from suites of cogenetic zircon from the Paleogene orthogneiss. Locally, the interpreted ages indicate that ductile deformation continued as late as Oligocene (Anderson and others, 1980; Silver and Anderson, 1984). The consistency of the deformational style is such that, although considerable variation in intensity exists, the fabric can be recognized and correlated in rocks away from the Paleogene orthogneiss.

  3. Early Tertiary mammals from North Africa reinforce the molecular Afrotheria clade

    PubMed Central

    Tabuce, Rodolphe; Marivaux, Laurent; Adaci, Mohammed; Bensalah, Mustapha; Hartenberger, Jean-Louis; Mahboubi, Mohammed; Mebrouk, Fateh; Tafforeau, Paul; Jaeger, Jean-Jacques

    2007-01-01

    The phylogenetic pattern and timing of the radiation of mammals, especially the geographical origins of major crown clades, are areas of controversy among molecular biologists, morphologists and palaeontologists. Molecular phylogeneticists have identified an Afrotheria clade, which includes several taxa as different as tenrecs (Tenrecidae), golden moles (Chrysochloridae), elephant-shrews (Macroscelididae), aardvarks (Tubulidentata) and paenungulates (elephants, sea cows and hyracoids). Molecular data also suggest a Cretaceous African origin for Afrotheria within Placentalia followed by a long period of endemic evolution on the Afro-Arabian continent after the mid-Cretaceous Gondwanan breakup (approx. 105–25 Myr ago). However, there was no morphological support for such a natural grouping so far. Here, we report new dental and postcranial evidence of Eocene stem hyrax and macroscelidid from North Africa that, for the first time, provides a congruent phylogenetic view with the molecular Afrotheria clade. These new fossils imply, however, substantial changes regarding the historical biogeography of afrotheres. Their long period of isolation in Africa, as assumed by molecular inferences, is now to be reconsidered inasmuch as Eocene paenungulates and elephant-shrews are here found to be related to some Early Tertiary Euramerican ‘hyopsodontid condylarths’ (archaic hoofed mammals). As a result, stem members of afrotherian clades are not strictly African but also include some Early Paleogene Holarctic mammals. PMID:17329227

  4. Beyond Colorado's Front Range - A new look at Laramide basin subsidence, sedimentation, and deformation in north-central Colorado

    Cole, James C.; Trexler, James H.; Cashman, Patricia H.; Miller, Ian M.; Shroba, Ralph R.; Cosca, Michael A.; Workman, Jeremiah B.

    2010-01-01

    preserved in the Colorado Headwaters Basin, suggesting this basin may have remained closed throughout the Paleocene and early Eocene. The field trip also addresses middle Eocene(?) folding of the late Laramide basin-fill strata, related to steep reverse faults that offset the Proterozoic crystalline basement. Late Oligocene magmatic activity is indicated by dikes, plugs, and eruptive volcanic rocks in the Rabbit Ears Range and the Never Summer Mountains that span and flank the Colorado Headwaters Basin. These intrusions and eruptions were accompanied by extensional faulting along predominantly northwesterly trends. Erosion accompanied the late Oligocene igneous activity and faulting, leading to deposition of boulder conglomerates and sandstones of the North Park Formation and high-level conglomerates across the landscape that preserve evidence of a paleo-drainage network that drained the volcanic landscape.

  5. Evidence From Svalbard for Cool Episodes in Early Tertiary Arctic Climate

    NASA Astrophysics Data System (ADS)

    Spielhagen, R. F.; Tripati, A.; Mac Niocaill, C.

    2008-12-01

    The Arctic is a climatically sensitive and important region. However, very little is known about the climatic and oceanographic evolution of the area, particularly prior to the Neogene. Until recently, the Arctic was assumed to be characterized by relatively warm conditions during the early Cenozoic. The Early Tertiary sedimentary sequence on Svalbard contains several layers with coal seams and broad-leaved plants which were commonly accepted as indicators of a generally temperate-warm climate. Here we report on the intermittent occurrence of certain temperature indicators in the succession, which may represent the first northern high- latitude record of near-freezing temperatures for the early Cenozoic. Besides the findings of probably ice- rafted erratic clasts in the Paleocene and Eocene sandstones and shales, we note especially the occurrence of glendonites which are pseudomorphs of calcite after ikaite (calcium carbonate hexahydrate). Stratigraphic control for the most important glendonite layers was improved by paleomagnetic investigations on the host sediment. We measured the chemical composition of Svalbard glendonites which is almost identical to that of similar pseudomorphs from the Lower Cretaceaous of Northern Canada. Mass spectrometric analyses of the glendonite calcite gave very low carbon isotope values. These values suggest a provenance of the calcium carbonate from marine organic carbon and connect our glendonites to the precursor mineral ikaite which has similar low values. Since a variety of studies has demonstrated that ikaite is stable only at temperatures close to freezing point, we have to infer low temperatures also for the deepositional environment of which the sediments were deposited that now hold glendonites. These results imply the occurrence of cooling phases episodically during the warm background climate of the Paleocene and Eocene, suggesting that temperature variability was much greater than previously recognized.

  6. Strontium isotopic evidence of shifting inflows to Eocene Lake Uinta in the Laramide foreland of Utah

    NASA Astrophysics Data System (ADS)

    Davis, S. J.; Wiegand, B. A.; Chamberlain, C. P.

    2007-12-01

    Isotopic records from the Uinta basin in Utah are evidence of an evolving landscape during the early Cenozoic. Combined with studies of provenance and paleoflow, oxygen and carbon isotopic results have recently been interpreted to reflect changes in hydrology and catchment hypsometry as the basin responded to developing relief in the foreland. We now present strontium isotope data from lacustrine limestones indicating significant and rapid (< 1 my) shifts in the source of inflowing surface waters. Provenance of Eocene sediments has been used to argue that water spilling south from an overfilled Lake Gosiute in the Greater Green River basin caused a highstand of the lake in the Piceance Creek basin, which in turn overtopped the Douglas Creek Arch and connected with Lake Uinta in the Uinta basin. The lake highstand was extremely productive, and resulted in the deposition of the rich "Mahogany zone" oil shales. New data shows that the 87Sr/86Sr ratio of lacustrine limestones collected in the Uinta basin is generally low (< 0.7105) for most of the Eocene, but spikes higher (to 0.7122) in samples of the Main Body of the Green River Formation near and within the Mahogany zone. We interpret this data to reflect a period of input of water from Lake Gosiute, where that lake's catchments included exposed basement that was much more radiogenic. The strontium data further supports the interpretation that intraforeland basin development in the central North American Cordillera was largely controlled by shifting drainage patterns as the landscape responded to ongoing Laramide tectonism.

  7. Paleomagnetic Results From the Mid-Tertiary Cripple Creek Diatreme Complex

    NASA Astrophysics Data System (ADS)

    Rampe, J. S.; Geissman, J. W.; Melker, M.

    2001-12-01

    The Cripple Creek diatreme complex, located about 30 km southwest of Pikes Peak, Colorado, is host to gold and high grade telluride deposits associated with mid-Tertiary alkaline magmatism. Formation of the diatreme took place between about 32.5 and 28.7 Ma, based on previously reported ArAr age determinations. The complex consists of breccia (the primary rock type), that was subsequently intruded by aphanitic phonolite, porphyritic phonolite, phonotephrite, and finally lamprophyre. Rocks presently at the surface were emplaced within a few kilometers of the paleosurface, followed by hydrothermal activity resulting in pervasive K metasomatism and gold mineralization. Mineralized deposits within the diatreme are currently being mined in an open pit fashion allowing for fresh three dimensional exposures of all representative rock types in the district. The Front Fange of Colorado, since cessation of northeast-directed Laramide compression, is characterized by east-west Rio Grande rift extension. Determining Laramide and younger deformation in the Front Range of Colorado is diffucult due to the dominance of Laramide structures and exposed Precambrian rocks with complex structural histories. Structures that affect the Cripple Creek diatreme complex and host Precambrian crystalline rocks clearly were active after intrusive activity and therefore reflect tectonism in the Front Range since early diatreme formation. Over 100 sites have been collected from all representative rock types in the district, with eight to ten oriented samples per site. Results indicate that the materials are capable of carrying geologically stable magnetizations and generally reveal excellent magnetization behavior using both AF and thermal methods. Many sites are associated with contact and breccia tests. Site mean directions are of both normal (D = 5.0° , I = 67.5° , α 95 = 6.4, κ = 89.2), N = 7 and reverse polarity (D = 162.2° , I = -67.3° , α 95 = 4.2, κ = 61.1) N =13; with site mean

  8. Mechanics of monoclinal systems in the Colorado Plateau during the Laramide orogeny

    NASA Astrophysics Data System (ADS)

    Yin, An

    1994-11-01

    Monoclines developed in the Colorado Plateau region during the Laramide orogeny are divided into western and eastern groups by a broad NNW trending antiform through the central part of the plateau. In the western group the major monoclines verge to the east, whereas in the eastern group the major monoclines verge to the west. Paleogeographic reconstruction based on paleocurrent indicators and sedimentary facies distribution suggests that the broad antiform was developed during the Laramide orogeny and was coeval with the formation of the monoclines in the plateau. This relationship implies that the monoclines were drag folds verging towards the center of the plateau as a response to the antiformal warping of the plateau. To simulate the warping of the plateau region and the stress distribution that produced the variable trends of the monoclines, an elastic thin plate model considering in-plane stress was developed. This model assumes that (1) sedimentation in the Laramide basins provided vertical loading along the edge of the plateau region, (2) frictional sliding was operating along the Laramide faults on the northern and eastern boundaries, and (3) the greatest regional compressive stress was oriented in the N 60 deg E direction and was applied uniformly along the western and southwestern sides of the plateau. Buoyancy due to instantaneous isostatic adjustment of crustal thickening or magmatic addition was also considered. The result of the model suggests that the frictional strength of the Uinta thrust system on the northern side of the plateau is at least 2 times greater than that along the Park Range and Sangre de Cristo thrust systems on the eastern side of the plateau in order to explain the observed monoclinal trends and the warping pattern within the plateau during the Laramide orogeny.

  9. Early Tertiary Exhumation, Erosion, and Sedimentation in the Central Andes, NW Argentina

    NASA Astrophysics Data System (ADS)

    Carrapa, B.; Decelles, P. G.; Gerhels, G.; Mortimer, E.; Strecker, M. R.

    2006-12-01

    Timing of deformation and resulting sedimentation patterns in the Altiplano-Puna Plateau-Eastern Cordillera of the southern Central Andes are the subject of ongoing controversial debate. In the Bolivian Altiplano, sedimentation into a foreland basin system commenced during the Paleocene. Farther south in the Puna and Eastern Cordillera of NW Argentina, a lack of data has precluded a similar interpretation. Early Tertiary non-marine sedimentary rocks are preserved within the present day Puna Plateau and Eastern Cordillera of NW Argentina. The Salar de Pastos Grandes basin in the Puna Plateau contains more than 2 km of Eocene alluvial and fluvial strata in the Geste Formation, deposited in close proximity to orogenic source terrains. Sandstone and conglomerate petrographic data document Ordovician quartzites and minor phyllites and schists as the main source rocks. Detrital zircon U-Pb ages from both the Geste Formation and from underlying Ordovician quartzite cluster in the 900-1200 Ma (Grenville) and late Precambrian-Cambrian (Panafrican) ranges. Sparse late Eocene (~37-34 Ma) grains are also present; their large size, euhedral shape, and decreasing mean ages upsection suggest that these grains are volcanogenic (i.e. ash fall contamination), derived from an inferred magmatic arc to the west. The Eocene ages corroborate mammalian paleontological dates, defining the approximate begin of deposition of the Geste Formation. Alternatively, these young zircons could be of plutonic origin; however, no Eocene plutons are present in the surrounding source rocks and this interpretation is not likely. From W to E, fluvial rocks of the Quebrada de los Colorados Formation show similar sedimentological features as those observed for the Geste Formation, suggesting a genetic link between the two. Detrital zircon U-Pb data show mainly Panafrican ages, with sparse ages in the 860-935 Ma range and a few mid-Proterozoic ages. More importantly, a significant number of late Eocene

  10. English as a Foreign Language Instructors' Induction: Early Practices of Language Teachers Teaching at Tertiary Level

    ERIC Educational Resources Information Center

    Ozturk, Mustafa; Yildirim, Ali

    2012-01-01

    This study aimed to investigate the nature of the induction process of English as a foreign language (EFL) teachers teaching at tertiary level through individual interviews. In order to gather intended data, fifteen novice instructors teaching at four different public universities in Ankara were interviewed on a basis of two criteria: (a) having 1…

  11. Spatial and mineralogic variation of Na-Ca alteration in Laramide porphyry systems of Arizona

    NASA Astrophysics Data System (ADS)

    Runyon, S.; Seedorff, E.; Barton, M. D.; Mazdab, F. K.; Lecumberri-Sanchez, P.; Steele-MacInnis, M.

    2017-12-01

    Na-Ca alteration is characterized by the metasomatic addition of Ca ± Na and the loss of K. Minor volumes of Na-Ca alteration in Laramide porphyry systems develops from 3 to 8 km paleodepth. Mineral assemblages, mineral compositions, hydrogen isotopes, whole-rock analyses, and reconnaissance fluid inclusion characteristics have been documented for Na-Ca alteration in Laramide porphyry systems such as Tea Cup and Sierrita. Volumetrically minor Na-Ca alteration in Laramide porphyry systems documented in this study commonly takes the form of one of three mineral assemblages: albite-epidote-chlorite, Na-plagioclase-actinolite ± epidote, and garnet- or diopside-stable Na-plagioclase-actinolite ± epidote. These different Na-Ca mineral assemblages have broad spatial relationships, from shallow albite-chlorite-epidote to deeper Na-plagioclase-actinolite within a given district. Hydrogen isotope data on Na-Ca alteration minerals shows consistently distinct δD compositions of Na-Ca alteration minerals compared to igneous minerals in a given district. Further, calculated hydrogen isotope composition of fluids in equilibrium with Na-Ca alteration minerals are consistently enriched in δD compared to magmatic-hydrothermal fluids. Whole-rock analyses show consistent losses of K and variable addition of Na and Ca across different Na-Ca alteration assemblages. Na-Ca alteration has been well documented associated with the Jurassic arc. Previous studies demonstrated through mass balance, timing and spatial relationships, isotopic, and fluid inclusion studies that Na-Ca alteration associated with the Jurassic arc likely formed from the circulation of external, highly saline, non-magmatic fluids (e.g., Battles and Barton, 1995; Dilles et al., 1995). Na-Ca alteration documented in Laramide systems is generally similar to Na-Ca alteration documented along the Jurassic arc in mineral assemblages, compositions, and timing, but the volume of Na-Ca alteration in the Laramide systems is

  12. Deformation in the mantle wedge associated with Laramide flat-slab subduction and implications for surface deformation during the Laramide orogeny

    NASA Astrophysics Data System (ADS)

    Behr, W. M.; Smith, D.

    2016-12-01

    Laramide crustal deformation in the Rocky Mountains of the west-central United States is often considered to relate to a narrow segment of shallow subduction of the Farallon slab, but there is no consensus as to how deformation along the slab-mantle lithosphere interface was accommodated. Here we investigate deformation in mantle rocks associated with hydration and shear above the flat-slab at its contact with the base of the North American plate. The rocks we focus on are deformed, hydrated, ultramafic inclusions hosted within diatremes of the Navajo Volcanic Field in the central Colorado Plateau that erupted during the waning stages of the Laramide orogeny. We document a range of deformation textures, including granular peridotites, porphyroclastic peridotites, mylonites, and cataclasites, which we interpret to reflect different proximities to a slab-mantle-interface shear zone. Mineral assemblages and chemistries constrain deformation to hydrous conditions in the temperature range 550-750 C. Despite the presence of hydrous phyllosilicates in modal percentages of up to 30%, deformation was dominated by dislocation creep in olivine. The mylonites exhibit an uncommon lattice preferred orientation (LPO) in olivine, known as B-type LPO in which the a-axes are aligned perpendicular to the flow direction. The low temperature, hydrated setting in which these fabrics formed is consistent with laboratory experiments that indicate B-type LPOs form under conditions of high stress and high water contents; furthermore, the mantle wedge context of these LPOs is consistent with observations of trench-parallel anisotropy in the mantle wedge above many modern subduction zones. Differential stress magnitudes in the mylonitic rocks estimated using paleopiezometry range from 290 to 444 MPa, and calculated effective viscosities using a wet olivine flow law are on the order of 10^19 to 10^23 Pa s. The high stress magnitudes, high effective viscosities, and high strains recorded in

  13. Reinterpretation of the palynology and age of Laramide syntectonic deposits, southwestern Montana, and revision of the Beaverhead Group

    NASA Astrophysics Data System (ADS)

    Nichols, D. J.; Perry, W. J., Jr.; Haley Johns, J. C.

    1985-02-01

    New palynological data from syntectonic deposits in southwestern Montana have major temporal implications for Laramide structural relations in the northern Rocky Mountains. Conglomerate and associated sandstones representing the bulk of material eroded from the thrust-faulted margin of the Blacktail-Snowcrest foreland massif are middle Campanian (Aquilapollenites senonicus Interval Zone; estimated absolute age 78 81 Ma). As a major consequence, the foreland buttress responsible for the shape of the southwestern Montana recess of the Cordilleran thrust belt was uplifted and in place by middle Campanian time. Palynomorph assemblages from the Campanian deposits include reworked spores of Paleozoic age that are evidence of provenance. Other less precisely dated syntectonic units in the area differ in age and provenance as well as lithology. Formerly, all these deposits were assigned to the Beaverhead Formation, which is raised to group status herein. The stratigraphic unit shed from the Blacktail-Snowcrest uplift is raised to formation status as the Lima Conglomerate. The term “Beaverhead Group” is restricted to the Lima Conglomerate and to contemporaneous and younger conglomeratic units that differ in lithology and probably in provenance; older sandstone units are removed from the Beaverhead Group. Deposits at the original type section of the Beaverhead Formation are not precisely dated but are no older than Campanian and probably no younger than early Maestrichtian.

  14. Kinematics and age of Early Tertiary trench parallel volcano-tectonic lineaments in southern Mexico: Tectonic implications

    NASA Astrophysics Data System (ADS)

    Martini, M.; Ferrari, L.; Lopez Martinez, M.; Cerca Martinez, M.; Serrano Duran, L.

    2007-05-01

    We present new geological, structural, and geochronological data that constrain the timing and geometry of Early Tertiary strike slip deformation in southwestern Mexico and its relation with the concurrent magmatic activity. Geologic mapping in Guerrero and Michoacan States documented two regional WNW trending volcano-tectonic lineaments sub parallel to the present trench. The southernmost lineament runs for ~140 km from San Miguel Totolapan area (NW Guerrero) to Sanchiqueo (SE Michoacan), and passes through Ciudad Altamirano. Its southeastern part is marked by the alignment of at least eleven silicic to intermediate major domes as well as by the course of the Balsas River. The northwestern part of the lineament is characterized by ductile left lateral shear zones in Early Tertiary plutonic rocks observed in the Rio Chiquito valley. Domes near Ciudad Altamirano are unaffected by ductile shearing and yielded a ~42 Ma 40Ar/39Ar age, setting a minimum age for this deformation. The northern volcano-tectonic lineament runs for ~190 km between the areas of Huitzuco in northern Guerrero and the southern part of the Tzitzio fold in eastern Michoacan. The Huautla, Tilzapotla, Taxco, La Goleta and Nanchititla silicic centers (all in the range 37-34 Ma) are emplaced along this lineament, which continues to the WNW trough a mafic dike swarm exposed north of Tiquicheo (37-35 Ma) and the Purungueo subvolcanic body (~42 Ma). These rocks, unaffected by ductile shearing, give a minimum age of deformation similar to the southern Totolapan-Sanquicheo lineament. Post ~42 Ma deformation is essentially brittle and is characterized by several left lateral and right lateral transcurrent faults with typical Riedel patterns. Other trench-parallel left lateral shear zones active in pre-Oligocene times were recently reported in western Oaxaca. The recognizing of Early Tertiary trench-parallel and left-lateral ductile shearing in internal areas of southern Mexico suggest a field of widely

  15. Late Cretaceous and early Tertiary plutonism and deformation in the Skagit Gneiss Complex, north Cascade Range, Washington and British Columbia

    Haugerud, R.A.; Van Der Heyden, P.; Tabor, R.W.; Stacey, J.S.; Zartman, R.E.

    1991-01-01

    The Skagit Gneiss Complex forms a more-or-less continuous terrane within the North Cascade Range. The complex comprises abundant plutons intruded at mid-crustal depths into a variety of metamorphosed supracrustal rocks of both oceanic and volcanic-arc origin. U-Pb zircon ages from gneissis plutons within and near the Skagit Gneiss Complex indicate magmatic crystallziations between 75 and 60 Ma. Deformation, recrystallization, and migmatization in part postdate intrusion of the 75-60 Ma plutons. This latest Cretaceous and earliest Tertiary plutonism and migmatization may reflect thermal relaxation following early Late Cretaceous orogeny. The complex was ductilely extended northwest-southeast shortly after intrusion of granite dikes at ~45 Ma, but before emplacement of the earliest (~34 Ma) plutons of the Cascade arc. -from Authors

  16. Subsurface stratigraphic cross sections of cretaceous and lower tertiary rocks in the Wind River Basin, central Wyoming: Chapter 9 in Petroleum systems and geologic assessment of oil and gas resources in the Wind River Basin Province, Wyoming

    Finn, Thomas M.

    2007-01-01

    The stratigraphic cross sections presented in this report were constructed as part of a project conducted by the U.S. Geological Survey to characterize and evaluate the undiscovered oil and gas resources of the Wind River Basin (WRB) in central Wyoming. The primary purpose of the cross sections is to show the stratigraphic framework and facies relations of Cretaceous and lower Tertiary rocks in this large, intermontane structural and sedimentary basin, which formed in the Rocky Mountain foreland during the Laramide orogeny (Late Cretaceous through early Eocene time). The WRB is nearly 200 miles (mi) long, 70 mi wide, and encompasses about 7,400 square miles (mi2) (fig. 1). The basin is structurally bounded by the Owl Creek and Bighorn Mountains on the north, the Casper arch on the east, the Granite Mountains on the south, and the Wind River Range on the west.

  17. Early Detection of Chronic Obstructive Pulmonary Disease in Apparently Healthy Attendants of Tertiary Care Hospital and Assessment of its Severity.

    PubMed

    Zubair, Tahira; Abbassi, Amanullah; Khan, Osama Ahsan

    2017-05-01

    Early detection of Chronic Obstructive Pulmonary Disease in apparently healthy attendants of tertiary care hospital and assessment of its severity. Cross-sectional, observational study. Study was conducted from January 2015 to July 2015 at Dow University Hospital, Ojha campus. Ascreening method was designed for apparently healthy individuals including attendants of patients, hospital staff, faculty and students, belonging to age group 18-60 years after excluding severe obesity and already diagnosed respiratory and cardiovascular diseases by means of history. Each participant performed pulmonary function tests via spirometer after filling a questionnaire based on various risk factors and symptoms of chronic obstructive pulmonary disease (COPD). Data was entered and analysed by SPSS-20. Out of the 517 participants, 122 (23.6%) were found to have COPD diagnosed by means of spirometry. Out of these, 23 (4.4%) had COPD stage I, 42 (8.1%) had COPD II, 34 (6.6%) had COPD III, and 23 (4.4%) had COPD IV. Exposure to smoking, wooden stoves, pesticides, biomass fuel, aerosol sprays, gas grill and vehicle exhaust were found to be statistically significant factors in relation to development of COPD. Apparently healthy individuals may have underlying COPD and active screening by means of spirometry plays vital role in early detection of COPD. Smoking and exposure to certain hazardous environmental pollutants are responsible for the development and progression of COPD.

  18. Lithospheric buckling and far-foreland deformation during the Laramide and Appalachian orogenies

    NASA Astrophysics Data System (ADS)

    Tikoff, B.; Siddoway, C. S.

    2017-12-01

    Major intraplate tectonics within North America (Laurentia) occurs during times of major orogenesis along the plate margins. During mountain building, typical structures of the hinterland are an orogenic plateau and fold-and-thrust belts, while in the far foreland (intraplate) areas long-wavelength ( 200 km or longer) folds and fault-reactivation features form. Long-wavelength folds are evident in both the Appalachian and Laramide orogenic forelands, with the stratigraphy recording the timing of the uplift. This contribution examines the model of lithospheric buckling - periodic folding associated with a horizontal endload on the edge of the plate - based on scaled, physical experiments and corroborated by numerical models. The Laramide (75-55 Ma) intraplate orogen in the classical location in Wyoming contains basement-cored arches spaced 200 km apart, for which the mechanism of uplift is questioned. Seismic evidence obtained for the Bighorn uplift, Wyoming, obtained by the EarthScope Bighorn project, shows an upwarp of the Moho beneath, but oblique to the trend of the surface exposure of the basement arch. Both the surface and Moho exhibit approximately the same structural relief. The seismic data exhibit no evidence for a regionally continuous decollement, nor is there evidence of rotation of structural markers within these features, of the type that is observed in the detached fold-and-thrust belt. The intraplate region affected by long-wavelength folding includes western Wyoming, with continuation of some features across the E-W-oriented Cheyenne belt (e.g., Rock Springs-Douglas Creek arch), Colorado Plateau, and High Plains east of the Rocky Mountains, where surface and subsurface structures display a series of anticlinal arches ("plains-type" folds). Appalachian mountain building also caused long-wavelength folding, with a spacing consistent with lithospheric buckling, mostly associated with the Devonian Acadian orogeny. The Laramide arches in the High Plains

  19. Deformation in the mantle wedge associated with Laramide flat-slab subduction

    NASA Astrophysics Data System (ADS)

    Behr, Whitney M.; Smith, Douglas

    2016-07-01

    Laramide crustal deformation in the Rocky Mountains of the west-central United States is often considered to relate to a narrow segment of shallow subduction of the Farallon slab, but there is no consensus as to how deformation along the slab-mantle lithosphere interface was accommodated. Here we investigate deformation in mantle rocks associated with hydration and shear above the flat-slab at its contact with the base of the North American plate. The rocks we focus on are deformed, hydrated, ultramafic inclusions hosted within diatremes of the Navajo Volcanic Field in the central Colorado Plateau that erupted during the waning stages of the Laramide orogeny. We document a range of deformation textures, including granular peridotites, porphyroclastic peridotites, mylonites, and cataclasites, which we interpret to reflect different proximities to a slab-mantle-interface shear zone. Mineral assemblages and chemistries constrain deformation to hydrous conditions in the temperature range ˜550-750°C. Despite the presence of hydrous phyllosilicates in modal percentages of up to 30%, deformation was dominated by dislocation creep in olivine. The mylonites exhibit an uncommon lattice preferred orientation (LPO) in olivine, known as B-type LPO in which the a-axes are aligned perpendicular to the flow direction. The low temperature, hydrated setting in which these fabrics formed is consistent with laboratory experiments that indicate B-type LPOs form under conditions of high stress and high water contents; furthermore, the mantle wedge context of these LPOs is consistent with observations of trench-parallel anisotropy in the mantle wedge above many modern subduction zones. Differential stress magnitudes in the mylonitic rocks estimated using paleopiezometry range from 290 to 444 MPa, and calculated effective viscosities using a wet olivine flow law are on the order of 1019-1023 Pa s. The high stress magnitudes, high effective viscosities, and high strains recorded in these

  20. Lead isotope compositions of Late Cretaceous and early Tertiary igneous rocks and sulfide minerals in Arizona: Implications for the sources of plutons and metals in porphyry copper deposits

    Bouse, R.M.; Ruiz, J.; Titley, S.R.; Tosdal, R.M.; Wooden, J.L.

    1999-01-01

    Porphyry copper deposits in Arizona are genetically associated with Late Cretaceous and early Tertiary igneous complexes that consist of older intermediate volcanic rocks and younger intermediate to felsic intrusions. The igneous complexes and their associated porphyry copper deposits were emplaced into an Early Proterozoic basement characterized by different rocks, geologic histories, and isotopic compositions. Lead isotope compositions of the Proterozoic basement rocks define, from northwest to southeast, the Mojave, central Arizona, and southeastern Arizona provinces. Porphyry copper deposits are present in each Pb isotope province. Lead isotope compositions of Late Cretaceous and early Tertiary plutons, together with those of sulfide minerals in porphyry copper deposits and of Proterozoic country rocks, place important constraints on genesis of the magmatic suites and the porphyry copper deposits themselves. The range of age-corrected Pb isotope compositions of plutons in 12 Late Cretaceous and early Tertiary igneous complexes is 206Pb/204Pb = 17.34 to 22.66, 207Pb/204Pb = 15.43 to 15.96, and 208Pb/204Pb = 37.19 to 40.33. These Pb isotope compositions and calculated model Th/U are similar to those of the Proterozoic rocks in which the plutons were emplaced, thereby indicating that Pb in the younger rocks and ore deposits was inherited from the basement rocks and their sources. No Pb isotope differences distinguish Late Cretaceous and early Tertiary igneous complexes that contain large economic porphyry copper deposits from less rich or smaller deposits that have not been considered economic for mining. Lead isotope compositions of Late Cretaceous and early Tertiary plutons and sulfide minerals from 30 metallic mineral districts, furthermore, require that the southeastern Arizona Pb province be divided into two subprovinces. The northern subprovince has generally lower 206Pb/204Pb and higher model Th/U, and the southern subprovince has higher 206Pb/204Pb and

  1. Possible origin of the Bighorn uplift, WY, by lithospheric buckling during the Laramide orogeny

    NASA Astrophysics Data System (ADS)

    Tikoff, B.; Siddoway, C. S.; Worthington, L. L.; Anderson, M. L.

    2017-12-01

    The EarthScope Bighorn Project investigated the Bighorn uplift, Wyoming, a foreland structure developed during the 75-55 Ma Laramide orogeny. Any model for the Bighorn uplift must account for several geological and geophysical results from the EarthScope broadband and passive-active seismic study, the broader context provided by USArray, and legacy datasets: 1) The Moho is bulged up below portions of the surface exposure of the basement arch; 2) a high-velocity, high-density material (the "7.x layer") is absent in the lower crust beneath the arch culmination; 3) Shear wave splitting analysis shows distinct mantle fabrics on either side of the uplift; 4) Crustal thicknesses varied widely prior to the Laramide-age deformation; 5) A lack of reflectors associated with a regional decollement; 6) The Bighorn arch forms one in an array of low-amplitude, large-wavelength folds throughout the High Plains region. The uplift borders a NNW-trending (E-dipping?) geophysical anomaly inferred to be Proterozoic suture. A lithospheric buckling model offers a framework that accommodates most of the geological and geophysical data. Lithospheric buckling is the concept of low-amplitude, large-wavelength (150-350 km) lithospheric folding developed in response to an end-load, replicated in scaled physical models. A buckling instability focuses initial deformation, with faults developed in layered media/crustal section as shortening progresses. The strength/age of the mantle controls the fold wavelength, based on examples from multiple orogens (e.g. Urals, central Asia). Rarely does the geometry of the upward Moho deflection identically mirror the surface uplift in scaled models, nor does it in the Bighorn uplift, where fold localization is likely controlled by a pre-existing Proterozoic suture and/or mantle asperity. Indicated by shear wave SKS splitting data, distinct mantle fabrics on either side of the uplift extend into the lithospheric mantle, indicated the presence of a deep

  2. Is the Vincent fault in southern California the Laramide subduction zone megathrust?

    NASA Astrophysics Data System (ADS)

    Xia, H.; Platt, J. P.

    2016-12-01

    The Vincent fault (VF) in the San Gabriel Mountains, southern California separates a Meso-Proterozoic gneiss complex and Mesozoic granitoid rocks in the upper plate from the ocean-affiliated Late Cretaceous Pelona schist in the lower plate, and it has been widely interpreted as the original Laramide subduction megathrust. A 500 to 1000 m thick mylonite zone, consisting of a low-stress (LS) section at the bottom, a high-stress (HS) section at the top, and a weakly deformed section in between, is developed above the VF. Our kinematic, thermobarometric and geochronological analysis of the mylonite zone indicates that the VF is a normal fault. Shear sense indicators including asymmetric porphyroblasts, quartz new grain fabric, mineral fish, and quartz CPO from the HS and the LS sections exhibit a top-to-SE sense of shear on the SW-dipping mylonitic foliation, which is contrary to what one would expect for the Laramide subduction megathrust. A few samples from the LS section were overprinted by HS microstructure, implying that the LS mylonites predate the HS mylonites. TitaniQ thermometer and Si-in-muscovite barometer show that the P-T conditions are 389 ± 6 °C, 5 kbar for the LS mylonites and 329 ± 6 °C, 2.4 kbar for HS mylonites. Considering the temporal sequence of HS and LS mylonites, they are likely to be formed during exhumation. A comparison with the lower plate leads to the same conclusion. The top 80-100 m of the Pelona schist underneath the VF is folded and also mylonitized, forming the Narrows synform and S3 simultaneously. Our previous study found that S3 of the Pelona schist has a top-to-SE sense of shear and similar P-T conditions as the LS mylonite in the upper plate, so S3 of the Pelona schist is likely to be formed together with the LS mylonites in the upper plate. While mylonitization of Pelona schist (S3) overprinted both the subduction-related S1 fabric and the return-flow-related S2 fabric, it is reasonable to argue that the mylonite zone above

  3. The effect of drainage reorganization on paleoaltimetry studies: An example from the Paleogene Laramide foreland

    NASA Astrophysics Data System (ADS)

    Davis, Steven J.; Wiegand, Bettina A.; Carroll, Alan R.; Chamberlain, C. Page

    2008-11-01

    Using multiple isotope systems, we examine the complex effects of drainage reorganization in the Laramide Foreland in the context of stable isotope paleoaltimetry. Strontium, oxygen and carbon isotopic data from lacustrine carbonates formed in the southwestern Uinta Basin, Utah between the Late Cretaceous and late Middle Eocene reveal a two stage expansion in the drainage basin of Lake Uinta beginning at ~ 53 Ma culminating in the Mahogany highstand at 48.6 Ma. A marked increase in 87Sr/ 86Sr ratios of samples from the Main Body of the Green River Formation is interpreted as the result of water overflowing the Greater Green River Basin in Wyoming and entering Lake Uinta from the east via the Piceance Creek Basin of northwestern Colorado. This large new source of water caused a rapid expansion of Lake Uinta and was accompanied by a significant and rapid increase in the O isotope record of carbonate samples by ~ 6‰. The periodic overspilling of Lake Gosiute probably became continuous at ~ 49 Ma, when the lake captured low- δ18O water from the Challis and Absaroka Volcanic Fields to the north. However, evaporation in the Greater Green River and Piceance Creek Basins meant that the waters entering Lake Uinta were still enriched in 18O. By ~ 46 Ma, inflows from the Greater Green River Basin ceased, resulting in a lowstand of Lake Uinta and the deposition of bedded evaporites in the Saline Facies of the Green River Formation. We thus show that basin development and lake hydrology in the Laramide foreland were characterized by large-scale changes in Cordilleran drainage patterns, capable of confounding paleoaltimetry studies premised on too few isotopic systems, samples or localities. In the case of the North American Cordillera of the Paleogene, we further demonstrate the likelihood that (1) topographic evolution of distal source areas strongly influenced the isotopic records of intraforeland basins and (2) a pattern of drainage integration between the hinterland and

  4. The Laramide Caborca orogenic gold belt of northwestern Sonora, Mexico; white mica 40Ar/39Ar geochronology from gold-rich quartz veins

    Izaguirre, Aldo; Kunk, Michael J.; Iriondo, Alexander; McAleer, Ryan J.; Caballero-Martinez, Juan Antonio; Espinosa-Arámburu, Enrique

    2016-02-12

    The COGB is approximately 600 kilometers long and 60 to 80 km wide, trends northwest, and extends from west-central Sonora to southern Arizona and California. The COGB contains mineralized gold-rich quartz veins that contain free gold associated with white mica (sericite), carbonate minerals (calcite and ankerite), and sulfides such as pyrite and galena. Limited geochronologic studies exist for parts of the COGB, and previous work was concentrated in mining districts. These previous studies recorded mineralization ages of approximately 70 to 40 Ma. Therefore, some workers proposed that the orogenic gold mineralization in the region occurred during a single pulse that was associated with the Laramide Orogeny that took place during the Cretaceous to early Eocene in the western margin of North America. However, the geochronologic dataset was quite limited, making any regional interpretations tenuous. Accordingly, one of the objectives of this geochronology study was to get a better representative sampling of the COGB in order to obtain a more complete record of the mineralization history. The 63 samples presented in this work are broadly distributed throughout the area of the COGB and allow us to better test the hypothesis that mineralization occurred in a single pulse.

  5. Low-temperature thermochronology of the Laramide Ranges and eastward translation of shortening in the Sevier Belt, Wyoming, Utah and Montana

    NASA Astrophysics Data System (ADS)

    Peyton, Sara Lynn

    This dissertation contains two studies that use very different techniques to investigate the Mesozoic and Cenozoic tectonics of the western USA. The first study investigates shortening in the Sevier thrust belt of northeast Utah and southwest Wyoming using cross sections and seismic reflection data. The second study investigates the low-temperature thermochronology of the Laramide Ranges using apatite (U-Th)/He dating. We used cross sections and seismic reflection data to investigate bed length discrepancies within the hanging wall of the Absaroka thrust in the Sevier thrust belt of northeast Utah and southwest Wyoming. Restoration of cross sections suggests that there was ˜8-14 km of pre-Absaroka-thrust shortening above the Jurassic Preuss salt detachment, but not below it, in the hanging wall of the Absaroka thrust. Reflection seismic data over the hanging wall of the Crawford thrust show that the Crawford thrust is not offset along the Preuss salt detachment, indicating that the additional shortening on the Absaroka plate was transferred east before main movement on the Crawford thrust. Although early displacement on the Crawford thrust cannot be ruled out as the cause of the extra shortening, surface and subsurface geology suggests slip from the western thrust system (Willard and Lost Creek thrusts) was transferred several tens of kilometers east along the Jurassic Preuss salt detachment between ˜102-90 Ma, to the future location of the Absaroka thrust hanging wall. The lack of deformation of the Crawford thrust on the seismic data, along with shortening and extension estimates from cross sections, also indicate that the magnitude of Paleocene and post-early Eocene shortening on the Medicine Butte thrust was essentially offset by subsequent extension on the middle Eocene to late Oligocene Almy-Acocks normal-fault system. For the second study in this dissertation, we dated 91 borehole and surface samples from Laramide-age, basement-cored uplifts of the Rocky

  6. The Pinto shear zone; a Laramide synconvergent extensional shear zone in the Mojave Desert region of the southwestern United States

    Wells, M.L.; Beyene, M.A.; Spell, T.L.; Kula, J.L.; Miller, D.M.; Zanetti, K.A.

    2005-01-01

    The Pinto shear zone is one of several Late Cretaceous shear zones within the eastern fringe of the Mesozoic magmatic arc of the southwest Cordilleran orogen that developed synchronous with continued plate convergence and backarc shortening. We demonstrate an extensional origin for the shear zone by describing the shear-zone geometry and kinematics, hanging wall deformation style, progressive changes in deformation temperature, and differences in hanging wall and footwall thermal histories. Deformation is constrained between ???74 and 68 Ma by 40Ar/39Ar thermochronology of the exhumed footwall, including multi-diffusion domain modeling of K-feldspar. We discount the interpretations, applied in other areas of the Mojave Desert region, that widespread Late Cretaceous cooling results from refrigeration due to subduction of a shallowly dipping Laramide slab or to erosional denudation, and suggest alternatively that post-intrusion cooling and exhumation by extensional structures are recorded. Widespread crustal melting and magmatism followed by extension and cooling in the Late Cretaceous are most consistent with production of a low-viscosity lower crust during anatexis and/or delamination of mantle lithosphere at the onset of Laramide shallow subduction. ?? 2005 Elsevier Ltd. All rights reserved.

  7. Evidence for Proterozoic and late Cretaceous-early Tertiary ore-forming events in the Coeur d'Alene district, Idaho and Montana

    Leach, D.L.; Hofstra, A.H.; Church, S.E.; Snee, L.W.; Vaughn, R.B.; Zartman, R.E.

    1998-01-01

    New 40Ar/39Ar age spectra on sericite and lead isotope data on tetrahedrite, siderite, galena, bournonite, and stibnite, together with previously published isotopic, geochemical, and geologic studies provide evidence for two major vein-forming events in the Coeur d'Alene district and surrounding area of the Belt basin. The data suggest that the zinc- and lead-rich veins (e.g., Bunker Hill and Star-Morning mines) formed in the Proterozoic (1.0 Ga), whereas the silver-rich veins (e.g., Silver belt mines), antimony veins (e.g., US Antimony mine), and gold-bearing quartz veins (Murry subdistrict) formed in Late Cretaceous to early Tertiary time.

  8. High resolution chronology of late Cretaceous-early Tertiary events determined from 21,000 yr orbital-climatic cycles in marine sediments

    NASA Technical Reports Server (NTRS)

    Herbert, Timothy D.; Dhondt, Steven

    1988-01-01

    A number of South Atlantic sites cored by the Deep Sea Drilling Project (DSDP) recovered late Cretaceous and early Tertiary sediments with alternating light-dark, high-low carbonate content. The sedimentary oscillations were turned into time series by digitizing color photographs of core segments at a resolution of about 5 points/cm. Spectral analysis of these records indicates prominent periodicity at 25 to 35 cm in the Cretaceous intervals, and about 15 cm in the early Tertiary sediments. The absolute period of the cycles that is determined from paleomagnetic calibration at two sites is 20,000 to 25,000 yr, and almost certainly corresponds to the period of the earth's precessional cycle. These sequences therefore contain an internal chronometer to measure events across the K/T extinction boundary at this scale of resolution. The orbital metronome was used to address several related questions: the position of the K/T boundary within magnetic chron 29R, the fluxes of biogenic and detrital material to the deep sea immediately before and after the K/T event, the duration of the Sr anomaly, and the level of background climatic variability in the latest Cretaceous time. The carbonate/color cycles that were analyzed contain primary records of ocean carbonate productivity and chemistry, as evidenced by bioturbational mixing of adjacent beds and the weak lithification of the rhythmic sequences. It was concluded that sedimentary sequences that contain orbital cyclicity are capable of providing resolution of dramatic events in earth history with much greater precision than obtainable through radiometric methods. The data show no evidence for a gradual climatic deterioration prior to the K/T extinction event, and argue for a geologically rapid revolution at this horizon.

  9. Low-Temperature Thermochronology of Laramide Ranges in Montana and Wyoming Provides Information on Exhumation and Tectonics Associated with Flat-Slab Subduction

    NASA Astrophysics Data System (ADS)

    Armenta, M.; Carrapa, B.; DeCelles, P. G.

    2014-12-01

    Timing of exhumation of Laramide basement uplifts can be used as a proxy for tectonic processes associated with thick-skinned deformation resulting from flat-slab subduction. Despite its significance, the timing and pattern of Laramide deformation remains poorly constrained in Montana. Thermochronological data from Wyoming indicate exhumation of Laramide ranges during the late Cretaceous and Paleogene. Whereas a few data exist for the Bearthooth Range in Montana; the exhumation history of most of the Montana ranges remains unexplored preventing testing of current tectonic models. We report apatite fission track thermochronologic (AFT) data from modern river sands derived from Laramide ranges, bedrock basement samples, and synorogenic conglomerate clasts to determine the regional exhumation history of the Beartooth, Gravelly, Tobacco Root, Ruby, the Highland Mountains, and the Wind River Range. AFT permits reconstruction of thermal histories and rates of erosion of the upper few kilometers of the crust. In particular detrital AFT of river sands provides information on regional exhumation of the drainage area. AFT detrital ages derived from the southern end of the Beartooth Range are dominated by a 60-80 Ma signal, consistent with ages reported for bedrock basement samples in the Beartooth Range. A Cenozoic synorogenic conglomerate clast was obtained from the Highland Mountains, AFT results show a 69.56 +/- 5.45 Ma cooling age. In the Wind River Range, Wyoming AFT data from a Cenozoic synorogenic conglomerate clast from the Wind River Formation indicates a 59.32 +/- 4.83 Ma cooling age. This age is consistent with AFT ages from Gannett Peak indicating rapid cooling at ~60 Ma and ~50 Ma (Fan and Carrapa, 2014). Overall, samples from the easternmost ranges, the Beartooth and Bighorn, clearly preserve a Cretaceous signal; samples from Wind River Range and the rest of southwest Montana mainly record a Cenozoic signal. This suggests deeper and younger exhumation to the

  10. Northward laramide thrusting in the quitovac region, northwestern sonora, mexico: Implications for the juxtaposition of paleoproterozoic basement blocks and the mojave-sonora megashear hypothesis

    Iriondo, Alexander; Martínez-Torres, Luis M.; Kunk, Michael J.; Atkinson, William W.; Premo, Wayne R.; McIntosh, William C.

    2005-01-01

    Restoration of 12%–30% Basin and Range extension allows direct interpretation of ductile fabrics associated with a stack of Laramide thrust faults in the Quitovac region in northwestern Sonora. The inferred direction of displacement of these thrusts varies gradually from N63°W to N23°E and is interpreted to represent a clockwise rotation of the direction of Laramide thrusting through time. The thrust faults represent a piggy-back sequence of thrusting propagating north, toward the foreland. The average direction and sense of displacement of the thrusts is N18°W, and the cumulative 45 km of estimated northward-directed displacement corresponds to ∼86% of shortening.Based on geochronological constraints, onset of thrusting in Quitovac occurred sometime between 75 and 61 Ma, whereas cessation occurred at ca. 39 Ma. The presence of Paleocene-Eocene orogenic gold mineralization, spatially associated with thrusting, strengthens our idea that compressional tectonism associated with the Laramide orogeny is a very important and widespread dynamometamorphic event in the region.Similarities in age, kinematics, and structural stratigraphy indicate that the thrusting in the Quitovac region may be equivalent to the Laramide Quitobaquito Thrust in southwestern Arizona. In both areas, thrust faults juxtapose the Paleoproterozoic Caborca and “North America” basement blocks. This juxtaposition was previously proposed as exclusively related to movements along the hypothetical Upper Jurassic Mojave-Sonora megashear. The Laramide northward displacements and clockwise rotations recorded in the Caborca block rocks in Quitovac contradict the southward displacements (∼800 km) and counterclockwise rotations inherent in the left-lateral Upper Jurassic Mojave-Sonora megashear hypothesis. We conclude that if this megashear exists in northwestern Sonora, its trace should be to the southwest of the Quitovac region.

  11. The Laramide Mesa formation and the Ojo de Agua caldera, southeast of the Cananea copper mining district, Sonora, Mexico

    Cox, Dennis P.; Miller, Robert J.; Woodbourne, Keith L.

    2006-01-01

    The Mesa Formation extends from Cananea, Mexico, southeast to the Sonora River and is the main host rock of Laramide porphyry copper deposits in the Cananea District and at the Alacran porphyry prospect to the east. The Mesa consists of two members-a lower andesite and an upper dacite. The lowest part of the dacite member is a crystal tuff about 100 m thick. This tuff is the outfall of a caldera centered near the village of Ojo de Agua, dated by 40Ar/39Ar at 65.8 Ma ?0.4. The Ojo de Agua Caldera is about 9 km in diameter and is filled by a light gray biotite dacite tuff with abundant flattened pumice fragments. The volume of the caldera is estimated to be 24 km3.

  12. Barriers to Early Initiation and Continuation of Breastfeeding in a Tertiary care Institute of Haryana: A Qualitative Study in Nursing Care Providers.

    PubMed

    Majra, Jai Pal; Silan, Vijay Kumar

    2016-09-01

    Ever increasing institutional deliveries in India has shifted the responsibility of timely initiation and continuation of breastfeeding from peripheral health workers and families to the nursing care providers of health facilities where the births take place. While institutional deliveries have increased to 72.6%, only 44.6% of the newborns enjoy early breastfeeding in India. To study the barriers to early initiation of breastfeeding in institutional delivery. A total 34 nursing care providers were selected randomly and five Focus Group Discussions (FGDs) were carried out. This Qualitative Study was conducted through FGDs among the nursing care providers of a tertiary care institute in the Indian State of Haryana, India. The analyses continued throughout the group discussions as the newly emerged themes were tested in the subsequent discussion. FGDs transcripts were analysed to enhance the robustness of the emerged domain. Major barriers to initiation of breast feeding identified included: lack of awareness regarding proper technique of breastfeeding and benefits of colostrum; breast abnormality like inverted/retracted nipples; obstetric/neonatal complications requiring specialised care; and cultural practices like giving pre-lacteals and gender discrimination. It was further reported that the manpower has not been rationalised with ever increasing number of institutional deliveries. The respondents though willing to promote early initiation and continuation of breastfeeding felt excessive workload as one of the major barriers due to multi-tasking nature of their job. The new challenges to the early initiation and continuation of breastfeeding are emerging due to change in the place of delivery which needs to be addressed at the policy level.

  13. Isotopic and anatomical evidence of an herbivorous diet in the Early Tertiary giant bird Gastornis. Implications for the structure of Paleocene terrestrial ecosystems

    NASA Astrophysics Data System (ADS)

    Angst, D.; Lécuyer, C.; Amiot, R.; Buffetaut, E.; Fourel, F.; Martineau, F.; Legendre, S.; Abourachid, A.; Herrel, A.

    2014-04-01

    The mode of life of the early Tertiary giant bird Gastornis has long been a matter of controversy. Although it has often been reconstructed as an apex predator feeding on small mammals, according to other interpretations, it was in fact a large herbivore. To determine the diet of this bird, we analyze here the carbon isotope composition of the bone apatite from Gastornis and contemporaneous herbivorous mammals. Based on 13C-enrichment measured between carbonate and diet of carnivorous and herbivorous modern birds, the carbonate δ13C values of Gastornis bone remains, recovered from four Paleocene and Eocene French localities, indicate that this bird fed on plants. This is confirmed by a morphofunctional study showing that the reconstructed jaw musculature of Gastornis was similar to that of living herbivorous birds and unlike that of carnivorous forms. The herbivorous Gastornis was the largest terrestrial tetrapod in the Paleocene biota of Europe, unlike the situation in North America and Asia, where Gastornis is first recorded in the early Eocene, and the largest Paleocene animals were herbivorous mammals. The structure of the Paleocene terrestrial ecosystems of Europe may have been similar to that of some large islands, notably Madagascar, prior to the arrival of humans.

  14. The emergence of modern type rain forests and mangroves and their traces in the palaeobotanical record during the Late Cretaceous and early Tertiary

    NASA Astrophysics Data System (ADS)

    Mohr, Barbara; Coiffard, Clément

    2014-05-01

    probably diversifying at mid latitudes. Later on, they slowly became restricted to lower latitudes as seen today. This fluctuation appears to be linked to climate change and are still reflected by the regional diversity of these groups, which reflect rather well rain forest evolution. When tracing the fossil record of rain forest plants we clearly see a pattern that suggests the onset of this type of environment during the late Late Cretaceous and spread during the early Tertiary with phases of retreat during the Oligocene and from the mid-Miocene onwards.

  15. Tertiary tectonic in the Tehuantepec Isthmus, Mexico

    SciT

    Lopez, F.A.

    1993-02-01

    A microplate model in the basement was proposed according to photointerpretation of satellite imagery and supported with microtectonic studies in the Tehuantepec's Isthmus. The microplate is located in the northwestern part of the [open quotes]Sierra de Chiapas,[close quotes] and structurally has lineaments that correspond with sinestral wrench faults oriented northeast-southwest and dextral faults oriented northwest-southeast. In the front of the microplate, these faults are joined in an arc form. The microplate began its movement forward to the north in the middle Tertiary. This movement originated in a regional compressional stress that was younger to the north. The stress changed themore » orientation of the anticline axis from northwest-southeast to west-east. In its western limit, the stress produces a sinestral shear stress that built a rotational deformation in the [open quotes]Sierra Atravesada,[close quotes] and represents a superimposed tectonic block over an ancient (laramide) orogeny. This system has also produced other secondary transtensional effects oriented northwest-southeast, represented along the [open quotes]Depression Central del Istmo.[close quotes] The microplate has formed a tensional system opening the [open quotes]Superior, Inferior, and Mar Muerto[close quotes] lagoons. The microplate is strongly related with the relief, seismic activity, and the tectonics of the salt of the Tehuantepec's Isthmus.« less

  16. Digital surfaces and hydrogeologic data for the Mesozoic through early Tertiary rocks in the Southeastern Coastal Plain in parts of Mississippi, Alabama, Georgia, South Carolina, and Florida

    Cannon, Debra M.; Bellino, Jason C.; Williams, Lester J.

    2012-01-01

    A digital dataset of hydrogeologic data for Mesozoic through early Tertiary rocks in the Southeastern Coastal Plain was developed using data from five U.S. Geological Survey (USGS) reports published between 1951 and 1996. These reports contain maps and data depicting the extent and elevation of the Southeast Coastal Plain stratigraphic and hydrogeologic units in Florida and parts of Mississippi, Alabama, Georgia, and South Carolina. The reports are: Professional Paper 1410-B (Renken, 1996), Professional Paper 1088 (Brown and others, 1979), Professional Paper 524-G (Applin and Applin, 1967), Professional Paper 447 (Applin and Applin, 1965), and Circular 91 (Applin, 1951). The digital dataset provides hydrogeologic data for the USGS Energy Resources Program assessment of potential reservoirs for carbon sequestration and for the USGS Groundwater Resource Program assessment of saline aquifers in the southeastern United States. A Geographic Information System (ArcGIS 9.3.1) was used to construct 33 digital (raster) surfaces representing the top or base of key stratigraphic and hydrogeologic units. In addition, the Geographic Information System was used to generate 102 geo-referenced scanned maps from the five reports and a geo-database containing structural and thickness contours, faults, extent polygons, and common features. The dataset also includes point data of well construction and stratigraphic elevations and scanned images of two geologic cross sections and a nomenclature chart.

  17. Tertiary Hyperparathyroidism

    PubMed Central

    Davies, D. R.; Dent, C. E.; Watson, Lyal

    1968-01-01

    In our first 200 cases of primary hyperparathyroidism confirmed by operation 12 were also shown to have a long history either of a malabsorption syndrome or of chronic renal-glomerular failure. We consider that they first went through a phase of secondary hyperparathyroidism, during which one or more of the glands became autonomous adenamata. This then produced the biochemical changes of “primary” hyperparathyroidism, necessitating excision of the adenoma. This condition is best described as “tertiary” hyperparathyroidism. The transition from secondary to tertiary hyperparathyroidism occurred in four of the 12 patients while under our observation. We think the same process can be traced retrospectively in the other eight cases. The concept of tertiary hyperparathyroidism may help to explain the high incidence of other diseases in association with primary hyperparathyroidism. The behaviour of the parathyroid glands provides a valuable model for the investigation of tumour formation in man. All states occurred in our patients with primary hyperparathyroidism, from normal through hyperplasia to adenoma formation and finally to parathyroid carcinoma. PMID:5691200

  18. The clinical presentation and early outcomes of necrotizing fasciitis in a Ugandan Tertiary Hospital--a prospective study.

    PubMed

    Magala, John; Makobore, Patson; Makumbi, Timothy; Kaggwa, Sam; Kalanzi, Edris; Galukande, Moses

    2014-07-28

    Necrotizing fasciitis is an infectious process characterized by rapidly progressing necrosis of superficial fascia and subcutaneous tissue with subsequent necrosis of overlying skin.Necrotizing fasciitis is a rare but fatal infection. The worldwide incidence is at 0.4 per 100,000. Mortality is up to 80% with no intervention, and 30-50% with intervention. Delay in intervention is associated with poor outcome. The risk factors for necrotizing fasciitis are diabetes mellitus, HIV, malignancy, illicit drug use, malnutrition among others.The aim of this study was to describe the clinical presentation and early outcomes of necrotizing fasciitis amongst Ugandan patients. A prospective descriptive case series study conducted at Mulago National Referral and Teaching hospital from 5th January to 30th April 2011. Patients with necrotizing fasciitis were consecutively recruited after clinical evaluation, laboratory and microbiological tests were performed. Aggressive debridement was done and broad-spectrum antibiotics administered. Patients were followed up on surgical wards. Ethical approval was obtained. Thirty five patients were recruited over a 4 months period. More males were affected with, M: F 3:1. The 20-40 years age group was most affected. Attainment of healthy granulation tissue took 19 days on average. Mortality rate was 14% (5/35). Limbs were the most affected body parts 20/35 (57%), the scrotum and perineum (23%). Among infants the scalp was the most affected. Co-morbidities included HIV 8/35 (17%), and DM (5%) among others. The commonest organisms were gram negative. Split skin grafting was necessary in 74% (26/35) of patients. There were a high number of patients with necrotizing fasciitis; it was associated with low mortality but high morbidity (long hospital stay). There was a high preponderance to males and limbs were the more affected body parts.

  19. The clinical presentation and early outcomes of necrotizing fasciitis in a Ugandan Tertiary Hospital- a prospective study

    PubMed Central

    2014-01-01

    Background Necrotizing fasciitis is an infectious process characterized by rapidly progressing necrosis of superficial fascia and subcutaneous tissue with subsequent necrosis of overlying skin. Necrotizing fasciitis is a rare but fatal infection. The worldwide incidence is at 0.4 per 100,000. Mortality is up to 80% with no intervention, and 30-50% with intervention. Delay in intervention is associated with poor outcome. The risk factors for necrotizing fasciitis are diabetes mellitus, HIV, malignancy, illicit drug use, malnutrition among others. The aim of this study was to describe the clinical presentation and early outcomes of necrotizing fasciitis amongst Ugandan patients. Methods A prospective descriptive case series study conducted at Mulago National Referral and Teaching hospital from 5th January to 30th April 2011. Patients with necrotizing fasciitis were consecutively recruited after clinical evaluation, laboratory and microbiological tests were performed. Aggressive debridement was done and broad-spectrum antibiotics administered. Patients were followed up on surgical wards. Ethical approval was obtained. Results Thirty five patients were recruited over a 4 months period. More males were affected with, M: F 3:1. The 20-40 years age group was most affected. Attainment of healthy granulation tissue took 19 days on average. Mortality rate was 14% (5/35). Limbs were the most affected body parts 20/35 (57%), the scrotum and perineum (23%). Among infants the scalp was the most affected. Co-morbidities included HIV 8/35 (17%), and DM (5%) among others. The commonest organisms were gram negative. Split skin grafting was necessary in 74% (26/35) of patients. Conclusion There were a high number of patients with necrotizing fasciitis; it was associated with low mortality but high morbidity (long hospital stay). There was a high preponderance to males and limbs were the more affected body parts. PMID:25069415

  20. Prevalence, severity and early outcomes of hypoxic ischemic encephalopathy among newborns at a tertiary hospital, in northern Tanzania.

    PubMed

    Simiyu, Irene N; Mchaile, Deborah N; Katsongeri, Kahindo; Philemon, Rune N; Msuya, Sia E

    2017-05-25

    Hypoxic Ischemic Encephalopathy (HIE) remains a problem of great concern worldwide especially in developing countries. The occurrence of a neurological syndrome can be an indicator of insult to the brain. We aimed to determine the prevalence, HIE proportions, neurological signs and early outcomes of newborns that developed birth asphyxia at KCMC Tanzania. A prospective study was conducted at KCMC from November 2014 to April 2015 among newborns with birth asphyxia. Sarnat and Sarnat score was used to assess newborns immediately after birth to classify HIE and were later followed daily for 7 days or until discharge. Of the 1752 deliveries during the study period, 11.5% (n = 201) had birth asphyxia. Of the 201 newborns, 187 had HIE. Of these 187 with HIE; 39.0% had moderate HIE and 10.2% had severe HIE according to the Sarnat and Sarnat classification. Neurological signs that were observed during the study period were; weak/absent reflexes (46.0%), hypotonia (43.3%) and lethargy (42.2%). Mortality was 9.1% among the 187 newborns with HIE. Mortality was higher among newborns with severe HIE 84.2% (16/19) compared to those with moderate HIE 1.4% (1/73). On the 7th day after delivery, 17.1% (32/187) of the newborns did not show any change from the initial score at delivery. Prevalence of birth asphyxia is high in our setting and most of the newborns (49%) end up with moderate/severe HIE. Good obstetric care and immediate resuscitation of newborns are vital in reducing the occurrence of HIE and improving the general outcome of newborns.

  1. A Glimpse at Late Mesozoic to Early Tertiary Offshore Stratigraphy from Wilkes Land, East Antarctica: Results of Strategic Dredging of the Mertz-Ninnis Trough

    NASA Astrophysics Data System (ADS)

    Schrum, H.; Domack, E.; Desantis, L.; Leventer, A.; McMullen, K.; Escutia, C.

    2004-12-01

    infilling a rifted basin of late Cretaceous age. Seaward dipping reflectors above the syn-rift strata represent post-rift deposits ranging from Paleogene to Quaternary. Included within this stratigraphy are lithified diamictites containing Mesozoic palynomorphs in addition to palynomorphs of Early Tertiary age (including dinoflagellates). Seaward dipping reflectors in the deep axis of the Mertz-Ninnis Trough were not sampled directly by our dredges, but are believed to be Lower Cretaceous siltstones by extrapolation to core DF-79-38, 100 km along strike to the southeast (Domack et al., 1980). Furthermore, the thermal maturity of the lignite samples recovered in our collections suggests that the coal is of Early Tertiary age, as are numerous organic-rich mudstones, which contain Paleogene palynomorphs. These results indicate that sedimentary strata in this portion of the Wilkes Land Margin contain significantly thick (greater than 2.7 km) post-rift (drift phase) marine sequences of both pre- and synglacial character. Strategic dredging is a promising methodology by which to sample stratigraphic succession in a cost effective manner along the East Antarctic margin in the absence of, or preparation for, International Ocean Drilling Projects on the shelf. Domack, E. W., Fairchild, W. W., and Anderson, J. B. (1980) Lower Cretaceous sediment from the East Antarctic continental shelf, Nature, 287, 625-626.

  2. Results of level-II oncoplasty in breast cancer patients: an early experience from a tertiary care hospital in Pakistan.

    PubMed

    Qureshi, Sajida; Ghazanfar, Shahriyar; Iqbal, Sumera; Bhatti, Abu Bakar Hafeez; Quraishy, Mohammad Saeed

    2014-03-01

    To assess the oncologic and cosmetic outcomes for breast cancer patients who underwent breast conservation therapy using Level II oncoplasty techniques. The prospective, non-randomised and descriptive study was conducted at the Department of Surgery, Unit IV of Civil Hospital, Karachi, from December 2009 to November 2011 in which 21 consecutive women with breast carcinoma who underwent wide local excision with remodeling mammoplasty were enrolled. All patients were reviewed by the surgeon and medical oncologist every 3 months for the first year. A grading system of 5-1 (excellent to poor) was employed and those with 3 or more were considered to have acceptable results. The mean patient age was 45.38 +/- 10.09 years (range: 26-70); 11 (52.3%) were premenopausal and 10 (47.7%) were postmenopausal; and 5 (27.8%) had family history of breast cancer. The mean size of the tumour determined by histology was 59.9 +/- 3.18 mm (range: 25-150). Eight (30%) patients received preoperative chemotherapy to downsize the tumour. Three (14.2%) patients received preoperative radiotherapy. Mean operative time was 1.59 +/- 0.52 hours (range: 1-2.5 hours). Mean volume of breast tissue excised from the breast containing the tumour was 545.27 +/- 412.06 cm3 (range: 43.70-1456). Assessment of excision margins showed no tumour at the margins of 19 (90.4%) patients. Two (9.5%) patients had close but negative margins. The mean hospital stay was 7.10 +/- 3.30 days (range: 4-15). There were early complications in 4 (19%) patients. One (4.76%) patient had late complications. Two (9.5%) patients developed tumour recurrence; both had an ipsilateral tumour recurrence. None of the patients developed metastases and one died of cardiac problem. Twenty (95.2%) patients had an acceptable post-surgical cosmetic result. Level II oncoplasty was a safe option in breast conservation allowing large-sized and difficult-location tumour excision with good cosmetic outcome in the study group. There is a need to

  3. Physiological responses of three deciduous conifers (Metasequoia glyptostroboides, Taxodium distichum and Larix laricina) to continuous light: adaptive implications for the early Tertiary polar summer.

    PubMed

    Equiza, M Alejandra; Day, Michael E; Jagels, Richard

    2006-03-01

    Polar regions were covered with extensive forests during the Cretaceous and early Tertiary, and supported trees comparable in size and productivity to those of present-day temperate forests. With a winter of total or near darkness and a summer of continuous, low-angle illumination, these temperate, high-latitude forests were characterized by a light regime without a contemporary counterpart. Although maximum irradiances were much lower than at mid-latitudes, the 24-h photoperiod provided similar integrated light flux. Taxodium, Larix and Metasequoia, three genera of deciduous conifers that occurred in paleoarctic wet forests, have extant, closely related descendents. However, the contemporary relative abundance of these genera differs greatly from that in the paleoarctic. To provide insight into attributes that favor competitive success in a continuous-light environment, we subjected saplings of these genera to a natural photoperiod or a 24-h photoperiod and measured gas exchange, chlorophyll fluorescence, non-structural carbohydrate concentrations, biomass production and carbon allocation. Exposure to continuous light significantly decreased photosynthetic capacity and quantum efficiency of photosystem II in Taxodium and Larix, but had minimal influence in Metasequoia. In midsummer, foliar starch concentration substantially increased in both Taxodium and Larix saplings grown in continuous light, which may have contributed to end-product down-regulation of photosynthetic capacity. In contrast, Metasequoia allocated photosynthate to continuous production of new foliar biomass. This difference in carbon allocation may have provided Metasequoia with a two fold advantage in the paleoarctic by minimizing depression of photosynthetic capacity and increasing photosynthetic surface.

  4. Exhumation and stress history in the sedimentary cover during Laramide thick-skinned tectonics assessed by stylolite roughness analysis.

    NASA Astrophysics Data System (ADS)

    Beaudoin, Nicolas; Lacombe, Olivier; David, Marie-Eléonore; Koehn, Daniel; Coltier, Robin

    2017-04-01

    Basement-involvement in shortening in forelands has a strong impact on the overlying sedimentary cover. The basement influences namely the geometry of folds and structures, the stress evolution and the nature and pathways for fluid migrations. However, these influences are poorly documented in context where the basement/cover interface is shallow (<6 km). This contribution presents the reconstruction of paleostress and vertical burial history of the Palaeozoic sedimentary strata affected by the Sevier-Laramide deformation at the front of the Rocky Mountains, in the Bighorn Basin (Wyoming, USA). Stylolite populations have been considered as part of an extensive microstructure investigation including also fractures, striated microfaults and calcite twins in key major structures such as the Sheep Mountain Anticline, the Rattlesnake Mountain Anticline, and the Bighorn Mountains Arch. Stylolite recognized in the field are clearly related to successive stages of deformation of the sedimentary cover, including fold development. We further apply a newly developed roughness analysis of pressure-solution stylolites which grant access (1) to the magnitude of the vertical principal stress, hence the maximum burial depth of the strata based on sedimentary stylolites, (2) to the principal stress orientations and regimes based on tectonic stylolites and (3) ultimately to the complete stress tensor when sedimentary and tectonic stylolites can be considered coeval. This approach was then coupled to mechanical properties of main competent formations exposed in the basin. Results of stylolite paleopiezometry, compared and combined to existing paleostress estimates from calcite twins and to exhumation reconstruction from low-temperature thermochronology, unravel the potential of the method to refine the structural history at the structure- and basin-scale. On top of the advances this case study adds to the methodology, the quantified reconstruction of stress-exhumation evolution in

  5. The Changing Nature of the Hawaiian Hotspot in the Late Cretaceous-Early Tertiary: Evidence From Helium Isotopes and Melt Inclusion Compositions

    NASA Astrophysics Data System (ADS)

    Keller, R.; Graham, D.; Duncan, R.; Regelous, M.

    2002-12-01

    Ocean Drilling Program Leg 197 recovered basaltic basement from three of the Late Cretaceous-Paleogene Emperor seamounts: Detroit (Sites 1203 and 1204), Nintoku (Site 1205), and Koko (Site 1206) seamounts. The depths of penetration into basement achieved by this drilling (140-450 m), the range of rock types recovered (hawaiites, alkalic basalts, and tholeiitic basalts), and the age range (48-76 Ma) makes this one of the most comprehensive collections of the volcanic products of the Hawaiian hotspot available, and opens up new opportunities to study the temporal evolution of the Hawaiian hotspot during the Late Cretaceous and early Tertiary. Previous studies of the chemical evolution of the Hawaiian hotspot (Lanphere et al., 1980; Keller et al., 2000) found significant temporal variations. For example, Sr isotopic ratios of the tholeiitic basalts remain fairly constant along the Hawaiian Islands/Ridge between Kilauea volcano on Hawaii and the Hawaiian-Emperor bend, but then decrease steadily northward along the Emperor seamounts. Trace element compositions (especially the rare earth element patterns) also show limited variations along the Hawaiian Islands/Ridge, but change toward more depleted values northward along the Emperor seamounts. The trend to more MORB-like compositions back in time was attributed to a decrease in distance between the hotspot and the nearest spreading center, although a more comprehensive study suggests that variations in lithospheric thickness also caused changes in the composition of the plume melts (Regelous et al., 2002). We will complement these previous studies and the ongoing work of the other Leg 197 scientists by studying two aspects of the Emperor seamount basalts: helium isotopes and melt inclusion compositions. We will measure the helium isotopic ratios of selected olivine separates from three of the Leg 197 drill sites and from DSDP Site 433 on Suiko seamount (65 Ma) to determine if the composition of the Hawaiian "plume signal

  6. GRANNY, a data bank of chemical analyses of Laramide and younger high-silica rhyolites and granites from Colorado and north-central New Mexico

    Steigerwald, Celia H.; Mutschler, Felix E.; Ludington, Steve

    1983-01-01

    GRANNY is a data bank containing information on 507 chemically analyzed Laramide or younger high-silica rhyolites and granites from Colorado and north-central New Mexico. The data were compiled from both published and unpublished sources. The data bank is designed to aid in the recognition of igneous rocks with a high exploration potential for the discovery of molybdenum (and other lithophile element) deposits. Information on source reference, geographic location, age, mineralogic and petrologic characteristics, major constituent analyses, and trace element analyses for each sample are given. The data bank is available in two formats: 1) paper- or microfiche-hardcopy, and 2) fixed format computer readable magnetic tape.

  7. Re-thinking the Laramide: Investigating the role of fluids in producing surface uplift using xenolith mineralogy and geochronology

    NASA Astrophysics Data System (ADS)

    Butcher, Lesley Ann

    associated with phase changes at depth. The results of this study substantiate the hypothesis that chemical alteration of lower continental crust by slab-derived fluids played a role in producing Laramide-related surface uplift of the Colorado Plateau and establishes chemical modification of continental lithosphere as a credible possibility for producing elevated regional topography in continental interiors.

  8. Centralisation for resection of the pancreatic head: A comparison of operative factors and early outcomes during the evolving unit and tertiary unit phases at a UK institution.

    PubMed

    Kostalas, M; Nageswaran, H; Froghi, S; Riga, A; Kumar, R; Menezes, N; Worthington, T R; Karanjia, N D

    2017-08-19

    To assess impact of centralisation on patients undergoing pancreatic head resections at a tertiary hepatobiliary (HPB) centre in the UK. Data were analysed from a prospectively maintained database from 1998 to 2014 on all patients undergoing pancreatic head resections. Two specific time periods were defined; these were the evolving unit phase (EU) from 1998 to 2009 and finally the established tertiary unit phase (TU) from 2010 to 2014. Peri-operative factors and post-operative outcomes were analysed. 395 resections were undertaken during the study period. Following establishment of our tertiary HPB unit, the volume of resections undertaken increased greater than three-fold with an associated increase in case-complexity (p = 0.004). Operating time was found to increase in the TU phase compared with EU phase (p=>0.0005) whilst there was no significant difference in the rate of peri-operative transfusion, or in post-operative morbidity rates. There was a significant reduction in the post-operative length of stay in the TU phase (p = 0.003) with a significantly higher proportion of patients being discharged within 9 days of their procedure (p=<0.0005). There was also a significant reduction in 30-day post-operative mortality in the TU phase (0.5%) compared with the EU phase (3%) (p = 0.029). Data from our series of 395 cases suggests that centralisation of pancreatic cancer services to a tertiary centre does result in improved patient outcomes. The benefits of a multi-disciplinary and specialist HPB service results in a high volume, high quality unit with improved patient outcomes. Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved.

  9. Knickzone propagation in the Black Hills and northern High Plains: a different perspective on the late Cenozoic exhumation of the Laramide Rocky Mountains

    Zaprowski, Brent J.; Evenson, Edward B.; Pazzaglia, Frank J.; Epstein, Jack B.

    2001-01-01

    Geomorphic research in the Black Hills and northern High Plains poses an intriguing hypothesis for the Cenozoic evolution of this salient of the Laramide Rockies. Most recently, geologists have appealed to late Cenozoic epeirogenic uplift or climate change to explain the post-Laramide unroofing of the Rockies. On the basis of field mapping and the interpretation of long-valley profiles, we conclude that the propagation of knickzones is the primary mechanism for exhumation in the Black Hills. Long profiles of major drainages show discrete breaks in the slope of the channel gradient that are not coincident with changes in rock type. We use the term knickzones to describe these features because their profiles are broadly convex over tens of kilometers. At and below the knickzone, the channel is incising into bedrock, abandoning a flood plain, and forming a terrace. Above the knickzone, the channel is much less incised, resulting in a broad valley bottom. Numerous examples of stream piracy are documented, and in each case, the capture is recorded in the same terrace level. These observations are consistent with migrating knickzones that have swept through Black Hills streams, rearranging drainages in their wake. We demonstrate there are two knickzone fronts associated with mapped terraces. Preliminary field evidence of soil development shows that these terraces are time transgressive in nature. Our data strongly suggest that knickzone propagation must be considered a viable mechanism driving late Cenozoic fluvial incision and exhumation of the northern High Plains and adjacent northern Rocky Mountains.

  10. 40Ar/39Ar Temporal Constraints on Eocene Uplift, Subsidence, and Paleohydrology in the Laramide Foreland, Western U. S.

    NASA Astrophysics Data System (ADS)

    Smith, M. E.; Carroll, A. R.; Singer, B. S.

    2004-12-01

    Due to their sensitivity to relatively subtle changes in regional drainage patterns, Eocene lake deposits of the Green River Formation offer a unique and richly detailed record of landscape modification caused by orogenic processes in the broken foreland of the western U. S. Recently obtained 40Ar/39Ar age determinations for 22 interbedded tephras provide excellent temporal resolution of this record, and enable inter-basin correlations at an unprecedented level of precision (approaching 2σ uncertainties of ± k.y.). Green River Formation strata span an interval of ~8 m.y., beginning and ending with freshwater fluvial-lacustrine deposits. Two episodes of regional basin closure and evaporite deposition, each lasting ˜1-2 m.y., coincide with evidence for active Laramide faulting at basin margins and increased rates of sediment accumulation. Evaporite deposition therefore appears to have been principally caused by enhanced uplift of basin sills rather than increased aridity. Regional stratigraphic relations, facies types, and 40Ar/39Ar geochronology permit deduction of the following paleodrainage history: 1) > ˜51.3 Ma: Fluvial-lacustrine deposition occurred in greater Green River, Piceance Creek and Uinta basins. The onset of lacustrine deposition is not well-dated due to a paucity of tephras. 2) ˜51.3-49.7 Ma: The greater Green River and Piceance Creek basins both became terminal sinks that received overflow from neighboring freshwater basins. Coarse clastic basin-marginal alluvial strata, cross-cutting fault relations, and pronounced differential subsidence in both basins indicate active uplift of the Uinta Mountains and surrounding ranges. 3) ˜49.7-49.1 Ma: Lake Gosiute expanded in extent, coincident with an influx of water and sediment derived from volcanic centers to the north. Episodic overflow over the eastern Uinta uplift flushed dissolved solutes southward, freshening Lake Gosiute while evaporite deposition continued in Lake Uinta. 4) ˜49.1-48.4 Ma

  11. New geochronological evidence for the timing of early Tertiary ridge subduction in southern Alaska: A section in Geologic studies in Alaska by the U.S. Geological Survey, 1998

    Bradley, Dwight C.; Parrish, Randall; Clendenen, William; Lux, Daniel R.; Layer, Paul W.; Heizler, Matthew; Donley, D. Thomas

    2000-01-01

    We present new U/Pb (monazite, zircon) and 40Ar/39Ar (biotite, amphibole) ages for 10 Tertiary plutons and dikes that intrude the Chugach–Prince William accretionary complex of southern Alaska. The Sanak pluton of Sanak Island yielded ages of 61.1±0.5 Ma (zircon) and 62.7±0.35 (biotite). The Shumagin pluton of Big Koniuji Island yielded a U/Pb zircon age of 61.1±0.3 Ma. Two biotite ages from the Kodiak batholith of Kodiak Island are nearly identical at 58.3±0.2 and 57.3±2.5 Ma. Amphibole from a dike at Malina Bay, Afognak Island, is 59.3±2.2 Ma; amphibole from a dike in Seldovia Bay, Kenai Peninsula, is 57.0±0.2 Ma. The Nuka pluton, Kenai Peninsula, yielded ages of 56.0±0.5 Ma (monazite) and 54.2±0.1 (biotite). Biotite plateau ages are reported for the Aialik (52.2±0.9 Ma), Tustumena (53.2±1.1 Ma), Chernof (54.2±1.1 Ma), and Hive Island (53.4±0.4 Ma) plutons of the Kenai Peninsula. Together, these new results confirm, but refine, the previously documented along-strike diachronous age trend of near-trench magmatism during the early Tertiary. We suggest that this event began at 61 Ma at Sanak Island, 2-4 m.y. later than previously supposed. An intermediate dike near Tutka Bay, Kenai Peninsula, yielded a hornblende age of 115±2 Ma. This represents a near-trench magmatic event that had heretofore gone unrecognized on the Kenai Peninsula; correlative Early Cretaceous near-trench plutons are known from the western Chugach Mountains near Palmer.

  12. Tertiary vegetation history

    C. I. Millar

    1996-01-01

    The Tertiary period, from 2.5 to 65 million years ago, was the time oforigin of the modern Sierra Nevada landscape. Climates, geology,and vegetation changed drastically in the Sierra Nevada during thistime, and analyses of this period provide both context for and insightinto vegetation dynamics of the current and future Sierra. During theearly Tertiary, warm-humid,...

  13. Early urinary diversion with ileal conduit and vesicovaginostomy in the treatment of radiation cystitis due to carcinoma cervix: a study from a tertiary care hospital in South India.

    PubMed

    Banerji, John Samuel; Devasia, Antony; Kekre, Nitin Sudhakar; Chacko, Ninan

    2015-10-01

    To study the magnitude of radiation cystitis following radiation therapy for carcinoma cervix, and propose an algorithm to decide on early diversion, with or without vesicovaginostomy. Women who developed radiation cystitis following radiotherapy for carcinoma cervix from January 1998 to December 2011 were included in this retrospective study. Electronic hospital records were analysed to document the presence of radiation cystitis. All women who developed evidence of radiation-induced cystitis, according to the common toxicity and Radiation Therapy Oncology Group criteria, were included in the study. We looked at transfusion requirements, number of hospital admissions, quality of life and cost involved. Chi-square tests were done where applicable. SPSS version 16 was used for analysis. Of the 902 patients who received radiation for carcinoma cervix in the 13-year period, 62 (6.87%) developed grade 3/4 cystitis. Twenty-eight of them underwent ileal conduit diversion, with 18 undergoing concomitant vesicovaginostomy. When compared with the patients who did not have diversion, the transfusion requirements, number of hospital admissions and quality of life had a statistically significant difference. Cost analysis of early diversion too showed a marginal benefit with early diversion. The limitation of the study was that it was retrospective in nature. In radiation cystitis, multiple hospital admissions and consequential increase in cost is the norm. In severe disease, early diversion is a prudent, cost-effective approach with good quality of life and early return to normal activity. © 2014 Royal Australasian College of Surgeons.

  14. Late Mesozoic and possible early Tertiary accretion in western Washington State: the Helena-Haystack melange and the Darrington- Devils Mountain fault zone

    Tabor, R.W.

    1994-01-01

    The Helena-Haystack melange (HH melange) and coincident Darrington-Devils Mountain fault zone (DDMFZ) in northwestern Washington separate two terranes, the northwest Cascade System (NWCS) and the western and eastern melange belts (WEMB). The two terranes of Paleozoic and Mesozoic rocks superficially resemble each other but record considerable differences in structural and metamorphic history. The HH melange is a serpentinite-matrix melange containing blocks of adjacent terranes but also exotic blocks. The HH melange must have formed between early Cretaceous and late middle Eocene time, because it contains tectonic clasts of early Cretaceous Shuksan Greenschist and is overlain by late middle Eocene sedimentary and volcanic rocks. The possible continuation of the DDMFZ to the northwest as the San Juan and the West Coast faults on Vancouver Island suggests that the structure has had a major role in the emplacement of all the westernmost terranes in the Pacific Northwest. -from Author

  15. The interplay of fold mechanisms and basement weaknesses at the transition between Laramide basement-involved arches, north-central Wyoming, USA

    NASA Astrophysics Data System (ADS)

    Neely, Thomas G.; Erslev, Eric A.

    2009-09-01

    Horizontally-shortened, basement-involved foreland orogens commonly exhibit anastomosing networks of bifurcating basement highs (here called arches) whose structural culminations are linked by complex transition zones of diversely-oriented faults and folds. The 3D geometry and kinematics of the southern Beartooth arch transition zone of north-central Wyoming were studied to understand the fold mechanisms and control on basement-involved arches. Data from 1581 slickensided minor faults are consistent with a single regional shortening direction of 065°. Evidence for oblique-slip, vertical axis rotations and stress refraction at anomalously-oriented folds suggests formation over reactivated pre-existing weaknesses. Restorable cross-sections and 3D surfaces, constrained by surface, well, and seismic data, document blind, ENE-directed basement thrusting and associated thin-skinned backthrusting and folding along the Beartooth and Oregon Basin fault systems. Between these systems, the basement-cored Rattlesnake Mountain backthrust followed basement weaknesses and rotated a basement chip toward the basin before the ENE-directed Line Creek fault system broke through and connected the Beartooth and Oregon Basin fault systems. Slip was transferred at the terminations of the Rattlesnake Mountain fault block by pivoting to the north and tear faulting to the south. In summary, unidirectional Laramide compression and pre-existing basement weaknesses combined with fault-propagation and rotational fault-bend folding to create an irregular yet continuous basement arch transition.

  16. Cooperative Tertiary Interaction Network Guides RNA Folding

    SciT

    Behrouzi, Reza; Roh, Joon Ho; Kilburn, Duncan

    2013-04-08

    Noncoding RNAs form unique 3D structures, which perform many regulatory functions. To understand how RNAs fold uniquely despite a small number of tertiary interaction motifs, we mutated the major tertiary interactions in a group I ribozyme by single-base substitutions. The resulting perturbations to the folding energy landscape were measured using SAXS, ribozyme activity, hydroxyl radical footprinting, and native PAGE. Double- and triple-mutant cycles show that most tertiary interactions have a small effect on the stability of the native state. Instead, the formation of core and peripheral structural motifs is cooperatively linked in near-native folding intermediates, and this cooperativity depends onmore » the native helix orientation. The emergence of a cooperative interaction network at an early stage of folding suppresses nonnative structures and guides the search for the native state. We suggest that cooperativity in noncoding RNAs arose from natural selection of architectures conducive to forming a unique, stable fold.« less

  17. Striped tertiary storage arrays

    NASA Technical Reports Server (NTRS)

    Drapeau, Ann L.

    1993-01-01

    Data stripping is a technique for increasing the throughput and reducing the response time of large access to a storage system. In striped magnetic or optical disk arrays, a single file is striped or interleaved across several disks; in a striped tape system, files are interleaved across tape cartridges. Because a striped file can be accessed by several disk drives or tape recorders in parallel, the sustained bandwidth to the file is greater than in non-striped systems, where access to the file are restricted to a single device. It is argued that applying striping to tertiary storage systems will provide needed performance and reliability benefits. The performance benefits of striping for applications using large tertiary storage systems is discussed. It will introduce commonly available tape drives and libraries, and discuss their performance limitations, especially focusing on the long latency of tape accesses. This section will also describe an event-driven tertiary storage array simulator that is being used to understand the best ways of configuring these storage arrays. The reliability problems of magnetic tape devices are discussed, and plans for modeling the overall reliability of striped tertiary storage arrays to identify the amount of error correction required are described. Finally, work being done by other members of the Sequoia group to address latency of accesses, optimizing tertiary storage arrays that perform mostly writes, and compression is discussed.

  18. Epidemiology, surgical management and early postoperative outcome in a cohort of gastric cancer patients of a tertiary referral center in relation to multi-center quality assurance studies.

    PubMed

    Garlipp, Benjamin; Schwalenberg, Jens; Adolf, Daniela; Lippert, Hans; Meyer, Frank

    2011-03-01

    The aim of the study was to analyze epidemiologic parameters, treatment-related data and prognostic factors in the management of gastric cancer patients of a university surgical center under conditions of routine clinical care before the onset of the era of multimodal therapies. By analyzing our data in relation with multi-center quality assurance trials [German Gastric Cancer Study - GGCS (1992) and East German Gastric Cancer Study - EGGCS (2004)] we aimed at providing an instrument of internal quality control at our institution as well as a base for comparison with future analyses taking into account the implementation of evolving (multimodal) therapies and their influence on treatment results. Retrospective analysis of prospectively gathered data of gastric cancer patients treated at a single institution during a defined 10-year time period with multivariate analysis of risk factors for early postoperative outcome. From 04/01/1993 through 03/31/2003, a total of 328 gastric cancer patients were treated. In comparison with the EGGCS cohort there was a larger proportion of patients with locally advanced and proximally located tumors. 272 patients (82.9%) underwent surgery with curative intent; in 88.4% of these an R0 resection was achieved (EGGCS/GGCS: 82.5%/71.5%). 68.2% of patients underwent preoperative endoluminal ultrasound (EUS) (EGGCS: 27.4%); the proportion of patients undergoing EUS increased over the study period. Diagnostic accuracy of EUS for T stage was 50.6% (EGGCS: 42.6%). 77.2% of operated patients with curative intent underwent gastrectomy (EGGCS/GGCS: 79.8%/71.1%). Anastomotic leaks at the esophagojejunostomy occurred slightly more frequently (8.8%) than in the EGGCS (5.9%) and GGCS (7.2%); however, postoperative morbidity (36.1%) and early postoperative mortality (5.3%) were not increased compared to the multi-center quality assurance study results (EGGCS morbidity, 45%); EGGCS/GGCS mortality, 8%/8.9%). D2 lymphadenectomy was performed in 72

  19. Correlation of the major late Jurassic —early Tertiary low- and highstand cycles of south-west Egypt and north-west Sudan

    NASA Astrophysics Data System (ADS)

    Wycisk, Peter

    1994-12-01

    The mainly continental deposits of northwest Sudan and south-west Egypt have been correlated with coeval shallow marine and marine deposits in northern Egypt along a north-south running cross-section, based on surface and subsurface data. The palaeodepth curve of northern Egypt illustrates the gradual seal-level rise, reaching its maximum during the Late Cretaceous with conspicuous advances during the Aptian and late Cenomanian. A general highstand is also recorded during the Campanian-Maastrichtian in north-west Sudan. A detailed facies correlation is given for the Aptian and late Cenomanian highstand in western Egypt. The correlation of the Cenomanian Bahariya and Maghrabi formations displays short-term relative sealevel fluctuations. The interpretation illustrates the extensiveness of related erosional processes in the hinterland, partly intensified by temporarily uplift of the Uweinat-Aswan High in the south. Regional uplift and constant erosion took place in south-west Egypt during Coniacian and Santonian times. The regional stratigraphic gaps and uncertain interpretation of the Bahariya Uplift are induced by the influence of the Trans-African Lineament, especially during the Late Cretaceous. Low-stand fluvial sheet sandstones characterized by non-cyclic sequence development and high facies stability occur, especially in the Neocomian and early Turonian. During the Barremian and Albian, fluvial architecture changes to more cyclic fluvial sequences and increasing soil formation, due to increasing subsidence, more humid climatic conditions and the generally rising sea level, culminating in the extensive shallow marine Abu Ballas and Maghrabi formations.

  20. Stereotactic body radiation therapy for early-stage primary lung cancer, is an active breath coordinator necessary? An audit from a tertiary cancer care center.

    PubMed

    Madhavan, R; Renilmon, P S; Nair, H M; Lal, A; Nair, S S; Unnikrishnan, U G; Makuny, D

    2017-01-01

    The hypofractionated stereotactic body radiation therapy (SBRT) has emerged as a safe and effective treatment modality for early-stage nonsmall cell lung carcinoma. An audit SBRT in primary lung cancer treated in our center with and without an active breath coordinator (ABC) was undertaken to evaluate its impact on target volumes and clinical outcomes. This was an observational study. Nine patients with lung carcinoma were treated from January 2014 to August 2016. Five patients were simulated using ABC and four patients with free breathing. Volumetric modulated arc therapy plans were generated using Monaco treatment planning software. Three patients were treated with a dose of 54 Gy in three fractions and six patients with a dose of 48 Gy in four fractions. The statistical analysis was performed using Kaplan-Meier survival. The mean planning target volumes (PTV) in ABC and free breathing groups were 42.19cc and 60.17cc, respectively. The mean volume of lung receiving 20, 10, and 5 Gy (V20, V10and V5) in ABC group were 5.37cc, 10.49cc, and 18.45cc whereas in free breathing 6.63cc, 12.74cc, and 20.64cc, respectively. At a median follow-up of 18 months, there were three local recurrences. No significant toxicity occurred in our series. Our initial results show that SBRT is well tolerated with good local control. Although the PTV volume and irradiated normal lung volume was higher in this group compared to ABC group, this did not translate to any added clinical toxicity.

  1. Low-Temperature Thermochronology of Borehole and Surface Samples From the Wind River and Beartooth Laramide Ranges, Wyoming and Montana, USA

    NASA Astrophysics Data System (ADS)

    Peyton, S. L.; Reiners, P. W.

    2007-12-01

    We dated borehole and surface samples from the Wind River and Beartooth Laramide-age, basement-cored uplifts of the Rocky Mountain foreland using the apatite (U-Th)/He (AHe) system. Comparison of these results to previously published apatite fission-track (AFT) data along with the incorporation of new He diffusion models (Shuster et al., 2006), reveals several new insights into, and poses new interpretational challenges for, the shallow exhumation histories of these ranges. Deep (2.2-2.8 km below surface) borehole samples from the Wind River Range have AHe ages of 9-12 Ma, and suggest at least 600 m of rapid exhumation during the Miocene. Shallower samples range from 35-66 Ma and are consistent with exhumation of a fossil partial retention zone. Previously-published apatite fission track (AFT) data from the same borehole show at least 2 km of rapid exhumation at ~45-38 Ma at depths where AHe ages are 9-50 Ma. This contrasts with the AHe ages which show slow exhumation between 12-66 Ma and have a trend on an age-elevation plot that appears to cut across the AFT age trend. Forward modeling of the cooling ages of these data using well-constrained thermal histories and conventional Durango apatite He diffusion data cannot explain these coupled AFT-AHe age-elevation relationships. However, modeling using diffusion kinetics of the Shuster et al. radiation-damage trapping model can explain the observed age trends, including the apparent presence of a 45-38 Ma exhumation event in the AFT data and its absence in the AHe data. In the model the shallow samples do not reach high enough temperatures for annealing of accumulated radiation damage, so He is trapped and ages are much older than predicted by conventional diffusion models. Previously-published AFT data from the Beartooth Range also show a large Laramide-age exhumation event, dated at 57-52 Ma. Similar to our observations from the Wind River Range, this event is not represented in our AHe results from borehole samples

  2. Control of Precambrian basement deformation zones on emplacement of the Laramide Boulder batholith and Butte mining district, Montana, United States

    Berger, Byron R.; Hildenbrand, Thomas G.; O'Neill, J. Michael

    2011-01-01

    What are the roles of deep Precambrian basement deformation zones in the localization of subsequent shallow-crustal deformation zones and magmas? The Paleoproterozoic Great Falls tectonic zone and its included Boulder batholith (Montana, United States) provide an opportunity to examine the importance of inherited deformation fabrics in batholith emplacement and the localization of magmatic-hydrothermal mineral deposits. Northeast-trending deformation fabrics predominate in the Great Falls tectonic zone, which formed during the suturing of Paleoproterozoic and Archean cratonic masses approximately 1,800 mega-annum (Ma). Subsequent Mesoproterozoic to Neoproterozoic deformation fabrics trend northwest. Following Paleozoic through Early Cretaceous sedimentation, a Late Cretaceous fold-and-thrust belt with associated strike-slip faulting developed across the region, wherein some Proterozoic faults localized thrust faulting, while others were reactivated as strike-slip faults. The 81- to 76-Ma Boulder batholith was emplaced along the reactivated central Paleoproterozoic suture in the Great Falls tectonic zone. Early-stage Boulder batholith plutons were emplaced concurrent with east-directed thrust faulting and localized primarily by northwest-trending strike-slip and related faults. The late-stage Butte Quartz Monzonite pluton was localized in a northeast-trending pull-apart structure that formed behind the active thrust front and is axially symmetric across the underlying northeast-striking Paleoproterozoic fault zone, interpreted as a crustal suture. The modeling of potential-field geophysical data indicates that pull-apart?stage magmas fed into the structure through two funnel-shaped zones beneath the batholith. Renewed magmatic activity in the southern feeder from 66 to 64 Ma led to the formation of two small porphyry-style copper-molybdenum deposits and ensuing world-class polymetallic copper- and silver-bearing veins in the Butte mining district. Vein orientations

  3. Geologic Map of the Denver West 30' x 60' Quadrangle, North-Central Colorado

    Kellogg, Karl S.; Shroba, Ralph R.; Bryant, Bruce; Premo, Wayne R.

    2008-01-01

    The Denver West quadrangle extends east-west across the entire axis of the Front Range, one of numerous uplifts in the Rocky Mountain region in which Precambrian rocks are exposed. The history of the basement rocks in the Denver West quadrangle is as old as 1,790 Ma. Along the east side of the range, a sequence of sedimentary rocks as old as Pennsylvanian, but dominated by Cretaceous-age rocks, overlies these ancient basement rocks and was upturned and locally faulted during Laramide (Late Cretaceous to early Tertiary) uplift of the range. The increasingly coarser grained sediments up section in rocks of latest Cretaceous to early Tertiary age record in remarkable detail this Laramide period of mountain building. On the west side of the range, a major Laramide fault (Williams Range thrust) places Precambrian rocks over Cretaceous sedimentary rocks. The geologic history of the quadrangle, therefore, can be divided into four major periods: (1) Proterozoic history, (2) Pennsylvanian to pre-Laramide, Late Cretaceous history, (3) Late Cretaceous to early Tertiary Laramide mountain building, and (4) post-Laramide history. In particular, the Quaternary history of the Denver West quadrangle is described in detail, based largely on extensive new mapping.

  4. Phanerozoic strike-slip faulting in the continental interior platform of the United States: Examples from the Laramide Orogen, midcontinent, and Ancestral Rocky Mountains

    Marshak, S.; Nelson, W.J.; McBride, J.H.

    2003-01-01

    The continental interior platform of the United States is that part of the North American craton where a thin veneer of Phanerozoic strata covers Precambrian crystalline basement. N- to NE-trending and W- to NW-trending fault zones, formed initially by Proterozoic/Cambrian rifting, break the crust of the platform into rectilinear blocks. These zones were reactivated during the Phanerozoic, most notably in the late Palaeozoic Ancestral Rockies event and the Mesozoic-Cenozoic Laramide orogeny - some remain active today. Dip-slip reactivation can be readily recognized in cross section by offset stratigraphic horizons and monoclinal fault-propagation folds. Strike-slip displacement is hard to document because of poor exposure. Through offset palaeochannels, horizontal slip lineations, and strain at fault bends locally demonstrate strike-slip offset, most reports of strike-slip movements for interior-platform faults are based on occurrence of map-view belts of en echelon faults and anticlines. Each belt overlies a basement-penetrating master fault, which typically splays upwards into a flower structure. In general, both strike-slip and dip-slip components of displacement occur in the same fault zone, so some belts of en echelon structures occur on the flanks of monoclinal folds. Thus, strike-slip displacement represents the lateral components of oblique fault reactivation: dip-slip and strike-slip components are the same order of magnitude (tens of metres to tens of kilometres). Effectively, faults with strike-slip components of displacement act as transfers accommodating jostling of rectilinear crustal blocks. In this context, the sense of slip on an individual strike-slip fault depends on block geometry, not necessarily on the trajectory of regional ??1. Strike-slip faulting in the North American interior differs markedly from that of southern and central Eurasia, possibly because of a contrast in lithosphere strength. Weak Eurasia strained significantly during the

  5. The Two Subduction Zones of the Southern Caribbean: Lithosphere Tearing and Continental Margin Recycling in the East, Flat Slab Subduction and Laramide-Style Uplifts in the West

    NASA Astrophysics Data System (ADS)

    Levander, A.; Bezada, M. J.; Niu, F.; Schmitz, M.

    2015-12-01

    The southern Caribbean plate boundary is a complex strike-slip fault system bounded by oppositely vergent subduction zones, the Antilles subduction zone in the east, and a currently locked Caribbean-South American subduction zone in the west (Bilham and Mencin, 2013). Finite-frequency teleseismic P-wave tomography images both the Atlanic (ATL) and the Caribbean (CAR) plates subducting steeply in opposite directions to transition zone depths under northern South America. Ps receiver functions show a depressed 660 discontinuity and thickened transition zone associated with each subducting plate. In the east the oceanic (ATL) part of the South American (SA) plate subducts westward beneath the CAR, initiating the El Pilar-San Sebastian strike slip system, a subduction-transform edge propagator (STEP) fault (Govers and Wortel, 2005). The point at which the ATL tears away from SA as it descends into the mantle is evidenced by the Paria cluster seismicity at depths of 60-110 km (Russo et al, 1993). Body wave tomography and lithosphere-asthenosphere boundary (LAB) thickness determined from Sp and Ps receiver functions and Rayleigh waves suggest that the descending ATL also viscously removes the bottom third to half of the SA continental margin lithospheric mantle as it descends. This has left thinned continental lithosphere under northern SA in the wake of the eastward migrating Antilles subduction zone. The thinned lithosphere occupies ~70% of the length of the El Pilar-San Sebastian fault system, from ~64oW to ~69oW, and extends inland several hundred kilometers. In northwestern SA the CAR subducts east-southeast at low angle under northern Colombia and western Venezuela. The subducting CAR is at least 200 km wide, extending from northernmost Colombia as far south as the Bucaramanga nest seismicity. The CAR descends steeply under Lake Maracaibo and the Merida Andes. This flat slab is associated with three Neogene basement cored, Laramide-style uplifts: the Santa Marta

  6. Effects of the Laramide Structures on the Regional Distribution of Tight-Gas Sandstone in the Upper Mesaverde Group, Uinta Basin, Utah

    NASA Astrophysics Data System (ADS)

    Sitaula, R. P.; Aschoff, J.

    2013-12-01

    sediment supply from west to southwest. Locally, paleocurrents are highly variable near SRS further suggesting UMG basin-fill was partitioned by uplift of SRS. Sandstone composition analysis also suggests the uplift of SRS causing the variation of source rocks in upper sequences than the lower sequences. In conclusion, we suggest that Uinta basin was episodically partitioned during the deposition of UMG due to uplift of Laramide structures in the basin and accommodation was localized in northeastern part. Understanding of structural controls on accommodation, sedimentation patterns and depositional environments will aid prediction of the best-producing gas reservoirs.

  7. Ethiopian Tertiary dike swarms

    NASA Technical Reports Server (NTRS)

    Mohr, P. A.

    1971-01-01

    Mapping of the Ethiopian rift and Afar margins revealed the existence of Tertiary dike swarms. The structural relations of these swarms and the fed lava pile to monoclinal warping of the margins partly reflect a style of continental margin tectonics found in other parts of the world. In Ethiopia, however, conjugate dike trends appear to be unusually strongly developed. Relation of dikes to subsequent margin faulting is ambiguous, and there are instances where the two phenomena are spatially separate and of differing trends. There is no evidence for lateral migration with time of dike injection toward the rift zone. No separate impingement of Red Sea, Gulf of Aden, and African rift system stress fields on the Ethiopian region can be demonstrated from the Tertiary dike swarms. Rather, a single, regional paleostress field existed, suggestive of a focus beneath the central Ethiopian plateau. This stress field was dominated by tension: there is no cogent evidence for shearing along the rift margins. A gentle compression along the rift floor is indicated. A peculiar sympathy of dike hade directions at given localities is evident.

  8. Oxygen isotope compositions of selected laramide-tertiary granitoid stocks in the Colorado Mineral Belt and their bearing on the origin of climax-type granite-molybdenum systems

    Hannah, J.L.; Stein, H.J.

    1986-01-01

    Quartz phenocrysts from 31 granitoid stocks in the Colorado Mineral Belt yield ??18O values less than 10.4???, with most values between 9.3 and 10.4???. An average magmatic value of about 8.5??? is suggested. The stocks resemble A-type granites; these data support magma genesis by partial melting of previously depleted, fluorine-enriched, lower crustal granulites, followed by extreme differentiation and volatile evolution in the upper crust. Subsolidus interaction of isotopically light water with stocks has reduced most feldspar and whole rock ??18O values. Unaltered samples from Climax-type molybdenumbearing granites, however, show no greater isotopic disturbance than samples from unmineralized stocks. Although meteoric water certainly played a role in post-mineralization alteration, particularly in feldspars, it is not required during high-temperature mineralization processes. We suggest that slightly low ??18O values in some vein and replacement minerals associated with molybdenum mineralization may have resulted from equilibration with isotopically light magmatic water and/or heavy isotope depletion of the ore fluid by precipitation of earlier phases. Accumulation of sufficient quantities of isotopically light magmatic water to produce measured depletions of 18O requires extreme chemical stratification in a large magma reservoir. Upward migration of a highly fractionated, volatile-rich magma into a small apical Climax-type diapir, including large scale transport of silica, alkalis, molybdenum, and other vapor soluble elements, may occur with depression of the solidus temperature and reduction of magma viscosity by fluorine. Climax-type granites may provide examples of 18O depletion in magmatic systems without meteoric water influx. ?? 1986 Springer-Verlag.

  9. Secondary and tertiary preventions of thyroid disease.

    PubMed

    Azizi, Fereidoun; Mehran, Ladan; Hosseinpanah, Farhad; Delshad, Hossein; Amouzegar, Atieh

    2018-05-01

    Secondary and tertiary preventions are concerned with the recognition of the disease process in a very early stage and delay in progression to complete disease and minimization of complications and the impact of illness. All articles related to secondary and tertiary prevention of thyroid diseases were reviewed. Using related key words, articles published between 2001 and 2015 were evaluated, categorized, and analyzed. In secondary prevention, congenital hypothyroidism and subclinical hypo and hyperthyroidism are equally important. Routine screening of patients with multinodular goiter by either ultrasonography or calcitonin is a controversial issue, while calcitonin assessments in medullary cancer and RET in family members are recommended. Screening of thyroid disease in pregnancy is limited to those with risk factors. Views regarding the importance of thyroid autoimmunity in secondary prevention are also presented. In tertiary prevention, prescribing excessive doses of levothyroxine, in the elderly in particular and appropriate care of all patients to avoid progression and complications are the key issues. Optimization of management of thyroid diseases requires timely screening, prevention of progression to more sever disease, optimal medical care, and avoidance of iatrogenic conditions.

  10. Breast Self Examination Practice among Female Students of Tertiary Institutions

    ERIC Educational Resources Information Center

    Agbonifoh, Julia Adesua

    2016-01-01

    Against the background of the dangers posed by breast cancer world-wide, and the importance of its early detection and therefore breast self examination (BSE), this study investigated the practice of BSE among female students in tertiary institutions in Edo state. A sample of 723 participants selected through a combination of multi-stage,…

  11. Rethinking the Tertiary Mathematics Curriculum

    ERIC Educational Resources Information Center

    Petocz, Peter; Reid, Anna

    2005-01-01

    Mathematics curriculum at the tertiary level is located within a range of social and cultural theories, and is often constructed by academics seeking to promulgate a particular view of mathematics. We argue that such a curriculum should incorporate a real acknowledgement of the different ways in which students understand the nature of mathematics…

  12. Buckets and Fire: Metaphors in Tertiary Teaching

    ERIC Educational Resources Information Center

    Emerson, Lisa; Mansvelt, Juliana

    2015-01-01

    This paper examines New Zealand tertiary teachers' use of metaphor and their attitudes to the consumer metaphor in relation to teaching. Based on interviews with 16 tertiary teachers, this study shows that although teachers believe the consumer metaphor is accepted by students, tertiary institutions and policy makers, and that it has affected…

  13. Expanding the Range of the First Step to Success Intervention: Tertiary-Level Support for Children, Teachers, and Families

    ERIC Educational Resources Information Center

    Frey, Andy J.; Small, Jason W.; Lee, Jon; Walker, Hill M.; Seeley, John R.; Feil, Edward G.; Golly, Annemeike

    2015-01-01

    This study presents the findings of a quasi-experimental feasibility study examining the Tertiary First Step intervention, an enhanced version of the First Step to Success early intervention program. Tertiary First Step was developed to engage families more effectively and influence and improve parenting practices for children having challenging…

  14. Expanding the Range of the First Step to Success Intervention: Tertiary-Level Support for Children, Teachers, and Families

    ERIC Educational Resources Information Center

    Frey, Andy J.; Small, Jason W.; Lee, Jon; Walker, Hill M.; Seeley, John R.; Feil, Edward G.; Golly, Annemeike

    2015-01-01

    This study presents the findings of a quasi-experimental feasibility study examining the Tertiary First Step intervention, an enhanced version of the First Step to Success early intervention program. Tertiary FirstStep was developed to engage families more effectively and influence and improve parenting practices for children having challenging…

  15. Numerical Modelling of Tertiary Tides

    NASA Astrophysics Data System (ADS)

    Gao, Yan; Correia, Alexandre C. M.; Eggleton, Peter P.; Han, Zhanwen

    2018-06-01

    Stellar systems consisting of multiple stars tend to undergo tidal interactions when the separations between the stars are short. While tidal phenomena have been extensively studied, a certain tidal effect exclusive to hierarchical triples (triples in which one component star has a much wider orbit than the others) has hardly received any attention, mainly due to its complexity and consequent resistance to being modelled. This tidal effect is the tidal perturbation of the tertiary by the inner binary, which in turn depletes orbital energy from the inner binary, causing the inner binary separation to shrink. In this paper, we develop a fully numerical simulation of these "tertiary tides" by modifying established tidal models. We also provide general insight as to how close a hierarchical triple needs to be in order for such an effect to take place, and demonstrate that our simulations can effectively retrieve the orbital evolution for such systems. We conclude that tertiary tides are a significant factor in the evolution of close hierarchical triples, and strongly influence at least ˜1% of all multiple star systems.

  16. Similarities and contrasts in tectonic and volcanic style and history along the Colorado plateaus-to-basin and range transition zone in Western Arizona: Geologic framework for tertiary extensional tectonics

    NASA Technical Reports Server (NTRS)

    Young, R. A.; Mckee, E. H.; Hartman, J. H.; Simmons, A. M.

    1985-01-01

    The overall temporal and spatial relations between middle Tertiary volcanism and tectonism from the Basin and Range province onto the edge of the Colorado Plateaus province suggest that a single magnetic-tectonic episode affected the entire region more or less simultaneously during this period. The episode followed a post-Laramide (late Eocene through Oligocene) period of 25 million years of relative stability. Middle Tertiary volcanism did not migrate gradually eastward in a simple fashion onto the Colorado Plateau. In fact, late Oligocene volcanism appears to be more voluminous near the Aquarius Mountains than throughout the adjacent Basin and Range province westward to the Colorado River. Any model proposed to explain the cause of extension and detachment faulting in the eastern part of the Basin and Range province must consider that the onset of volcanism appears to have been approximately synchronous from the Colorado River region of the Basin and Range across the transition zone and onto the edge of the Colorado Plateaus.

  17. Latitudinal gradients in tertiary molluscan faunas of the Pacific coast

    Addicott, W.O.

    1970-01-01

    Tertiary molluscan faunas of the middle latitudes of the marginal eastern North Pacific are characterized by warm-water taxa whose descendants now live in more southerly latitudes. A series of profiles in which cumulative percentages of warm-water faunal elements are plotted against latitude show progressive northward decreases in the percentage of these elements in the faunas of Pacific coast Tertiary stages. Systematic changes in the relative position of these latitudinal gradients during the Middle and Late Tertiary are related to climatic change in the Pacific Basin. Widespread tropical marine climate in the middle latitudes of the eastern North Pacific during the Eocene is indicated by widespread faunal units characterized by high levels of taxonomic diversity. Succeeding Early Oligocene faunas are less diverse, suggesting cooler climatic conditions. Unusually low representations of warm-water genera characterize the molluscan faunas of the Acila shumardi Zone in central California (latitude 34??-37??N). The anomalously cool-water aspect of these faunas may record the occurrence of upwelling along a bold linear segment of the Pacific coast. During the Late Oligocene or the Early Miocene, they are replaced by faunas of unusually warm-water aspect resulting in positive anomalies in Miocene latitudinal faunal gradients in central California. The Miocene anomalies seem to result from the development of an irregular Neogene coastline with extensive, newly established shallow-water embayments. ?? 1970.

  18. Ketene reactions with tertiary amines.

    PubMed

    Allen, Annette D; Andraos, John; Tidwell, Thomas T; Vukovic, Sinisa

    2014-01-17

    Tertiary amines react rapidly and reversibly with arylketenes in acetonitrile forming observable zwitterions, and these undergo amine catalyzed dealkylation forming N,N-disubstituted amides. Reactions of N-methyldialkylamines show a strong preference for methyl group loss by displacement, as predicted by computational studies. Loss of ethyl groups in reactions with triethylamine also occur by displacement, but preferential loss of isopropyl groups in the phenylketene reaction with diisopropylethylamine evidently involves elimination. Quinuclidine rapidly forms long-lived zwitterions with arylketenes, providing a model for catalysis by cinchona and related alkaloids in stereoselective additions to ketenes.

  19. Paleomagnetic Results for Eocene Volcanic Rocks from Northeastern Washington and the Tertiary Tectonics of the Pacific Northwest

    NASA Astrophysics Data System (ADS)

    Fox, Kenneth F., Jr.; Beck, Myrl E., Jr.

    1985-04-01

    The direction of remanent magnetization for 102 sites in Eocene volcanic and volcaniclastic rocks of the O'Brien Creek Formation, Sanpoil Volcanics, and Klondike Mountain Formation suggests approximately 25° of clockwise rotation of a 100 by 200 km area in northeastern Washington. The volcanic rocks consist chiefly of rhyodacite and quartz latite flows, with intercalated ash flow tuff and volcaniclastic layers. These rocks have been sampled at 102 sites distributed among five volcanotectonic depressions: the Toroda Creek, Republic, Keller, and First Thought grabens and the Spokane-Enterprise lineament. The volcanic rocks probably range in age from 55 m.y. to about 48 m.y., and the 50- to 48-m.y.-old volcanic rocks within this suite appear to be rotated as much as the older rocks. Previous investigators have shown that 40-m.y.-old and younger plutonic rocks of northwestern Washington are not rotated; hence we infer that the north-central Washington rocks were rotated to their present declination between 48 and 40 m.y. B.P. (during the middle and/or late Eocene). During early Eocene time this region was extended in a westward direction through crustal necking, gneiss-doming, diking, and graben formation. Internal deformation of the region related to this crustal extension was extreme, but most bedrock units that were formed concurrent with the crustal extension were probably in place prior to the rotation; hence we infer that the rotation was chiefly accommodated by movement on faults peripheral to the sampled area. Faults active during Paleogene time appear to define boundaries of a triangular crustal block (the Sanpoil block), encompassing much of northeastern Washington, northern Idaho, northwestern Montana, and adjacent parts of British Columbia. The faults include the Laramide thrusts of the Rocky Mountain thrust belt, the strike-slip faults of the Lewis and Clark line, and strike-slip faults of the Straight Creek-Fraser zone. We suggest that during early

  20. Is the sword moss (Bryoxiphium) a preglacial Tertiary relict?

    PubMed

    Patiño, Jairo; Goffinet, Bernard; Sim-Sim, Manuela; Vanderpoorten, Alain

    2016-03-01

    The disjunction of floras between East Asia, Southeast North America, West North America, and Southwest Eurasia has been interpreted in terms of the fragmentation of a once continuous mixed mesophytic forest that occurred throughout the Northern Hemisphere due to the climatic and geological changes during the late Tertiary. The sword moss, Bryoxiphium, exhibits a distribution that strikingly resembles that of the mesophytic forest elements such as Liriodendron and is considered as the only living member of an early Tertiary flora in Iceland. These hypotheses are tested here using molecular dating analyses and ancestral area estimations. The results suggest that the extant range of Bryoxiphium results from the fragmentation of a formerly wider range encompassing North America and Southeast Asia about 10 million years ago. The split of continental ancestral populations is too recent to match with a continental drift scenario but is spatially and temporally remarkably congruent with that observed in Tertiary angiosperm relict species. The timing of the colonization of Iceland from Macaronesian ancestors, about two million years ago, is, however, incompatible with the hypothesis that Bryoxiphium is the only living member of an early Tertiary flora of the island. Alaska was recurrently colonized from East Asia. The ability of Bryoxiphium to overcome large oceanic barriers is further evidenced by its occurrence on remote oceanic archipelagos. In particular, Madeira was colonized twice independently from American and East Asian ancestors, respectively. The striking range disjunction of Bryoxiphium is interpreted in terms of its mating system, as the taxon exhibits a very singular pattern of spatial segregation of the sexes. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. Large-scale mud diapirism as a record of late-stage Laramide tectonism within the Eocene Green River Formation, Wyoming

    NASA Astrophysics Data System (ADS)

    Hudson, Samuel M.; Klimek, Jason N.

    2017-08-01

    The Gruene and Verde mud diapirs, which range in size from 70 to 95 m in diameter, are exposed within the Wilkins Peak Member of the Eocene Green River Formation near Flaming Gorge Reservoir, southwest Wyoming. These diapirs are sourced from the lower unit of the Wilkins Peak Member (lower, middle, and upper units can be defined based on dominant lithology), and were emplaced into the upper unit of the Wilkins Peak Member, cross-cutting hundreds of meters of strata. The structures contain brecciated dolomicritic and lime mudstones with minor amounts of siliciclastic clays. Pervasive quartz veining is present throughout both diapirs. Though heavily disturbed, original bedding can be seen in both localities, either dipping radially outward towards the margins of the diapir as is dominant at the Gruene diapir or tilted but near horizontal as is the dominant expression at the smaller Verde diapir. The Gruene diapir can be seen in contact with several fluvial sandstone bodies within the upper Wilkins Peak strata in outcrop, and these fluvial sandstones transition from regional, near-horizontal dips to steeply dipping beds and bedsets within 50 m of the diapir. These sands show no signs of brittle deformation, and dip ranges from 20 to 50° radially away from the center of the diapir to the north, west, and east where sands are observed. These are interpreted here to have been deformed pre-lithification, at or near the surface, by the rising mud diapir, offering an important control on the timing of diapirism near the end of the early Eocene. Deformation structures such as clastic dikes, brecciation, and convoluted bedding have been documented by others at or near this stratigraphic interval in Utah, Wyoming, and Colorado, and these smaller structures have been interpreted as seismites. We suggest that these mud diapirs are a larger-scale expression of this same seismic activity.

  2. Diversification of Tertiary Education in Switzerland.

    ERIC Educational Resources Information Center

    Crausaz, Roselyne

    The structure of Switzerland's educational system is described including the types of secondary schools and/or courses and the system of tertiary education. Fields of study, types of institutions, and characteristics of tertiary education in Switzerland are discussed. The chapter on students covers admission procedures, trends in enrollment,…

  3. Changing Tertiary Education in Modern European Society.

    ERIC Educational Resources Information Center

    Council for Cultural Cooperation, Strasbourg (France).

    Reports on recent developments and problems in the diversification of tertiary education in seven Western European countries are presented by members of the Working Party on the Diversification of Tertiary Education. Policy analysis and evaluation and recommendations for future policy are also provided. As a policy, diversification refers to the…

  4. Tertiary Education and Training in Australia, 2010

    ERIC Educational Resources Information Center

    National Centre for Vocational Education Research (NCVER), 2012

    2012-01-01

    This publication presents information on tertiary education and training during 2010, including statistics on participation and outcomes. The definition of tertiary education and training adopted for this publication is formal study in vocational education and training (VET) and higher education, including enrolments in Australian Qualifications…

  5. Reductive amination of tertiary anilines and aldehydes.

    PubMed

    Lv, Yunhe; Zheng, Yiying; Li, Yan; Xiong, Tao; Zhang, Jingping; Liu, Qun; Zhang, Qian

    2013-10-09

    An unprecedented oxidant-mediated reductive amination of tertiary anilines and aldehydes without external reducing agents was developed via the nucleophilic attack of the oxygen atom of the carbonyl group to in situ generated iminium ions, in which tertiary anilines were used as both nitrogen source and reducing agent for the first time.

  6. Nodular tertiary syphilis in an immunocompetent patient*

    PubMed Central

    Bittencourt, Maraya de Jesus Semblano; de Brito, Arival Cardoso; Nascimento, Bianca Angelina Macêdodo; Carvalho, Alessandra Haber; Drago, Marion Guimarães

    2016-01-01

    Acquired syphilis can be divided into primary, secondary, latent, and tertiary stages. About 25% of patients with untreated primary syphilis will develop late signs that generally occur after three to five years, with involvement of several organs. The authors present an immunocompetent female who developed a tertiary stage syphilis presenting with long-standing nodular plaques. PMID:27579755

  7. Tertiary Education in Britian. National Report.

    ERIC Educational Resources Information Center

    Eggleston, J.

    Some of the major trends in British Tertiary education are reviewed. Types of schools and/or courses in British secondary education are examined in relation to student preparation for tertiary education. The present system of higher Education in Britian is described including types of institutions and academic structures, admission requirements,…

  8. [Visa at a tertiary hospital].

    PubMed

    Martínez-Jiménez, S; Lluch-Colomer, A; Desongles-Corrales, T; Bernal-González, D; Santos-Rubio, M D; Alfaro-Lara, E R; Galván-Banqueri, M

    2013-01-01

    To analyze the visa application process and his activity at a tertiary hosipital. Descriptive study of the drug s visa activity during the period April 2011-April 2012. We designed a database and defined categories on the study variables: patients and recipes. For patients admitted to the Visa Unit, issues detected were recorded based on a previously established classification. 6738 patients were included. They involved the visa of 8,465 recipes. The visa was applied to 170 drugs and nutrition products different, being the majority Tacrolimus. During this period, we detected a total of 420 incidents being the most frequent «No clinical document» (46.67%) and the «Formal completion errors» (28.57%). This work has allowed a more detailed analysis of the activity, the types of incidents and the identification of areas for improvement. Copyright © 2013 SEFH. Published by AULA MEDICA. All rights reserved.

  9. Tertiary evolution of the northeastern Venezuela offshore

    NASA Astrophysics Data System (ADS)

    Ysaccis B., Raul

    1998-12-01

    On the northeastern offshore Venezuela, the pre-Tertiary basement consists of a deeply subducted accretionary complex of a Cretaceous island arc system that formed far to the west of its present location. The internal structure of this basement consists of metamorphic nappes that involve passive margin sequences, as well as oceanic (ophiolitic) elements. The Tertiary evolution of the northeastern Venezuela offshore is dominated by Paleogene (Middle Eocene-Oligocene) extension and Neogene transtension, interrupted by Oligocene to Middle Miocene inversions. The Paleogene extension is mainly an arc-normal extension associated with a retreating subduction boundary. It is limited to the La Tortuga and the La Blanquilla Basins and the southeastern Margarita and Caracolito subbasins. All of these basins are farther north of and not directly tied to the El Pilar fault system. On a reconstruction, these Paleogene extensional systems were located to the north of the present day Maracaibo Basin. By early Miocene the leading edge of the now overall transpressional system had migrated to a position to the north of the Ensenada de Barcelona. This relative to South America eastward migration is responsible for the Margarita strike-slip fault and the major inversions that began during the Oligocene and lasted into the Middle Miocene. The Bocono-El Pilar-Casanay-Warm Springs and the La Tortuga-Coche-North Coast fault systems are exclusively Neogene with major transtension occurring during the Late Miocene to Recent and act independently from the earlier Paleogene extensional system. They are responsible for the large Neogene transtensional basins of the area: the Cariaco trough, the Northern Tuy-Cariaco and the Paria sub-basins, and the Gulf of Paria Basin. This latest phase is characterized by strain-partitioning into strike slip faults, a transtensional northern domain and a transpressional southern domain that is responsible for the decollement tectonics and/or inversions of the

  10. Constraints on Late Tertiary Elevation of the Colorado Plateau From Carbonate Clumped- Isotope Thermometry

    NASA Astrophysics Data System (ADS)

    Huntington, K. W.; Wernicke, B. P.; Eiler, J. M.

    2009-05-01

    Topography is a first-order expression of the buoyancy of the lithosphere, and the timing and pattern of elevation change can place fundamental constraints on mantle flow and continental dynamics. We investigate the timing of Colorado Plateau uplift using clumped-isotope thermometry to independently constrain both the temperature and isotopic composition of ancient surface waters based on the 13C-18O bond enrichment in carbonates. Analyses of ancient lake sediments from the plateau interior and adjacent lowlands are compared to signals recorded by modern sediments collected over 3 km of elevation in the region. Comparison of modern and ancient samples deposited near sea level provides an opportunity to quantify the influence of climate on changes in temperature, and therefore more accurately assess the contribution from changes in elevation. Both modern and ancient (Miocene-Pliocene) carbonates record near-surface spring/summer lake water temperatures that vary strongly with elevation. Modern and ancient lake carbonate temperature lapse rates of -4.2±0.7°C/km and -4.1±0.6°C/km, respectively, suggest that little if any post-16 Ma change in elevation of the southern plateau is required to explain the data. Agreement of δ18O data for modern and ancient surface waters supports this interpretation. The zero-elevation intercept of the ancient trend is 7.7±2.0°C warmer than the modern trend, indicating significant cooling due to climate change since Late Miocene time. The temperature data are permissive of up to 450 m of uplift or 250 m of subsidence of the plateau interior since 6 Ma, but do not support km-scale changes. Combined with previous constraints, the data suggest that most uplift of the south-central plateau occurred during Late Cretaceous/earliest Tertiary time, favoring uplift mechanisms such as crustal thickening by channel flow, hydration of the mantle lithosphere due to volatile flux from the Laramide flat slab, or dynamic topography associated with

  11. Middle Tertiary continental rift and evolution of the Red Sea in southwestern Saudi Arabia

    Schmidt, Dwight Lyman; Hadley, Donald G.; Brown, Glen F.

    1983-01-01

    Throughout early Tertiary time, the Arabian Shield erosion surface remained near sea level. First-stage uplift of the Red Sea Escarpment began during middle Miocene time, as evidenced by the coarse polymictic boulder conglomerate of the Bathan formation. Second-stage scarp uplift and second-stage sea-floor spreading followed during Pliocene, Pleistocene, and Holocene time.

  12. Parathyroid carcinoma presenting as tertiary hyperparathyroidism.

    PubMed Central

    Sherlock, D. J.; Newman, J.; Holl-Allen, R. T.

    1985-01-01

    A case of malignant transformation in established secondary hyperparathyroidism presenting as tertiary hyperparathyroidism is reported. Although rare, this occurrence has important medical and surgical implications. Images Figure 1 PMID:3983057

  13. The Cretaceous/Tertiary Extinction Controversy Reconsidered.

    ERIC Educational Resources Information Center

    McCartney, Kevin; Nienstedt, Jeffrey

    1986-01-01

    Reviews varying positions taken in the Cretaceous/Tertiary (K/Y) extinction controversy. Analyzes and contests the meteoritic impact theory known as the Alvarez Model. Presents an alternative working hypothesis explaining the K/T transition. (ML)

  14. Lower Tertiary laterite on the Iceland-Faeroe Ridge and the Thulean land bridge

    Nilsen, T.H.

    1978-01-01

    CORES of a lower Tertiary lateritic palaeosol resting on basalt were recovered1 from Deep Sea Drilling Project Site 336 (Leg 38) on the north-east flank of the Iceland-Faeroe Ridge (Fig. 1), a major aseismic oceanic ridge that, together with Iceland, forms the Icelandic transverse ridge 2. The transverse ridge extends from the West European continental margin to the East Greenland continental margin, forming the geographic boundary and a partial barrier to flow of water between the Norwegian-Greenland Sea to the north and the northern North Atlantic Ocean to the south. The palaeosol indicates that at least part of the Iceland-Faeroe Ridge was above sea level during early Tertiary time3. Palaeogeographic and palaeooceanographic reconstructions suggest that it formed the main part of the Thulean land bridge that connected South-east Greenland and the Faeroe islands during the early Tertiary4. This report summarises the subsidence history of the Iceland-Faeroe Ridge relative to early Tertiary seafloor spreading, basaltic volcanism, and the development of the proposed Thulean land bridge. ?? 1978 Nature Publishing Group.

  15. Paleomagnetism and geochronology of an Early Proterozoic quartz diorite in the southern Wind River Range, Wyoming, USA

    Harlan, S.S.; Geisman, J.W.; Premo, W.R.

    2003-01-01

    We present geochronologic and paleomagnetic data from a north-trending quartz diorite intrusion that cuts Archean metasedimentary and metaigneous rocks of the South Pass Greenstone Belt of the Wyoming craton. The quartz diorite was previously thought to be either Archean or Early Proterozoic (?) in age and is cut by north and northeast-trending Proterozoic diabase dikes of uncertain age, for which we also report paleomagnetic data. New U-Pb analyses of baddeleyite and zircon from the quartz diorite yield a concordia upper intercept age of 2170 ?? 8 Ma (95% confidence). An 40Ar/39Ar amphibole date from the same sample yields a similar apparent age of about 2124 ?? 30 Ma (2??), thus confirming that the intrusion is Early Proterozoic in age and that it has probably not been thermally disturbed since emplacement. A magmatic event at ca. 2.17 Ga has not previously been documented in the Wyoming craton. The quartz diorite and one of the crosscutting diabase dikes yield essentially identical, well-defined characteristic remanent magnetizations. Results from eight sites in the quartz diorite yield an in situ mean direction of north declination and moderate to steep positive inclination (Dec.=355??, Inc.=65??, k=145, ??95=5??) with a paleomagnetic pole at 84??N, 215??E (??m=6??, ??p=7??). Data from other diabase dike sites are inconsistent with the quartz diorite results, but the importance of these results is uncertain because the age of the dikes is not well known. Interpretation of the quartz diorite remanent magnetization is problematic. The in situ direction is similar to expected directions for magnetizations of Late Cretaceous/early Tertiary age. However, there is no compelling evidence to suggest that these rocks were remagnetized during the late Mesozoic or Cenozoic. Assuming this magnetization to be primary, then the in situ paleomagnetic pole is strongly discordant with poles of 2167, 2214, and 2217 Ma from the Canadian Shield, and is consistent with proposed

  16. An analytic model for limiting high density LH transition by the onset of the tertiary instability

    SciT

    Singh, Raghvendra, E-mail: rsingh129@gmail.com; Jhang, Hogun; Kaang, Helen H.

    2016-07-15

    We perform an analytic study of the tertiary instability driven by a strong excitation of zonal flows during high density low to high (LH) mode transition. The drift resistive ballooning mode is assumed to be a dominant edge turbulence driver. The analysis reproduces main qualitative features of early computational results [Rogers and Drake, Phys. Rev. Lett. 81, 4396 (1998); Guzdar et al., Phys. Plasmas 14, 020701 (2007)], as well as new characteristics of the maximum edge density due to the onset of the tertiary instability. An analytical scaling indicates that the density scaling of LH transition power may be determinedmore » by the onset condition of the tertiary instability when the operating density approaches to the Greenwald density.« less

  17. Correlation of tertiary formations of Alaska

    MacNeil, F.S.; Wolfe, J.A.; Miller, D.J.; Hopkins, D.M.

    1961-01-01

    Recent stratigraphic and paleontologic studies have resulted in substantial revision of the age assignments and inter-basin correlations of the Tertiary formations of Alaska as given in both an earlier compilation by P. S. Smith (1939) and a tentative chart prepared for distribution at the First International Symposium on Arctic Geology at Calgary, Alberta (Miller, MacNeil, and Wahrhaftig, 1960). Current work in Alaska by the U. S. Geological Survey and several oil companies is furnishing new information at a rapid rate and further revisions may be expected. The correlation chart (Fig. 1), the first published chart to deal exclusively with the Tertiary of Alaska, had the benefit of a considerable amount of stratigraphic data and fossil collections from some oil companies, but recent surface mapping and drilling by other oil companies in several Tertiary basins undoubtedly must have produced much more information. Nevertheless, the extent of available data justifies the publication of a revised correlation chart at this time.

  18. Mortality in newborns referred to tertiary hospital: An introspection

    PubMed Central

    Aggarwal, Kailash Chandra; Gupta, Ratan; Sharma, Shobha; Sehgal, Rachna; Roy, Manas Pratim

    2015-01-01

    Background: India is one of the largest contributors in the pool of neonatal death in the world. However, there are inadequate data on newborns referred to tertiary care centers. The present study aimed to find out predictors of mortality among newborns delivered elsewhere and admitted in a tertiary hospital in New Delhi between February and September 2014. Materials and Methods: Hospital data for were retrieved and analyzed for determining predictors for mortality of the newborns. Time of admission, referral and presenting clinical features were considered. Results: Out of 1496 newborns included in the study, there were 300 deaths. About 43% deaths took place in first 24 hours of life. Asphyxia and low birth weight were the main causes of death in early neonatal period, whereas sepsis had maximum contribution in deaths during late neonatal period. Severe hypothermia, severe respiratory distress, admission within first 24 hours of life, absence of health personnel during transport and referral from any hospital had significant correlation with mortality. Conclusions: There is need for ensure thermoregulation, respiratory sufficiency and presence of health personnel during transport. PMID:26288788

  19. American Tertiary mollusks of the genus Clementia

    Woodring, W.P.

    1927-01-01

    Aside from its value as an aid in determining the age of Tertiary beds, the chief interest of the genus Clementia lies in the anomalous features of its present and former distribution. An attempt is made in this paper to trace its geologic history, to point out its paleobiologic significance, and to describe all the known American Tertiary species. The fossils from Colombia used in preparing this report were collected during explorations made under the direction of Dr. 0. B. Hopkins, chief geologist of the Imperial Oil Co. (Ltd.), who kindly donated them to the United States National Museum. Dr. T. Wayland Vaughan, of the Scripps Institution of Oceanography, furnished information relating to specimens collected by him in Mexico. Dr. Bruce L. Clark, of the University of California; Dr. G. Dallas Hanna, of the California Academy of Sciences; Dr. H. A. Pilsbry, of the Philadelphia Academy of Natural Sciences; and Dr. W. D. Matthew, of the American Museum of Natural History, generously loaned type specimens and other material. Doctor Clark and Doctor Hanna also gave information concerning the Tertiary species from California. Mr. Ralph B. Stewart, of the University of California, read the manuscript, and I have taken advantage of his suggestions. I am also indebted to Mr. L. R. Cox, of the British Museum, for information relating to the fossil species from Persia, Zanzibar, and Burma, and to Dr. Axel A. Olsson, of the International Petroleum Co., for data concerning undescribed Tertiary species from Peru.

  20. Diversification of Tertiary Education in France.

    ERIC Educational Resources Information Center

    Didier, Paul

    Following an outline of education, particularly secondary education, the French system of tertiary education is described. The orientation of studies offered in the three two-year cycles of study is described. The differences between the national institutes and the universities are explained. The remainder of the report contains admission…

  1. Incorporating Online Tools in Tertiary Education

    ERIC Educational Resources Information Center

    Steenkamp, Leon P.; Rudman, Riaan J.

    2013-01-01

    Students currently studying at tertiary institutions have developed a set of attitudes and aptitudes as a result of growing up in an IT and media-rich environment. These attitudes and aptitudes influence how they learn and in order to be effective, lecturers must adapt to address their learning preferences and use the online teaching tools that…

  2. Smart Utilization of Tertiary Instructional Modes

    ERIC Educational Resources Information Center

    Hamilton, John; Tee, Singwhat

    2010-01-01

    This empirical research surveys first year tertiary business students across different campuses regarding their perceived views concerning traditional, blended and flexible instructional approaches. A structural equation modeling approach shows traditional instructional modes deliver lower levels of student-perceived learning quality, learning…

  3. Indigenous Students in the Tertiary Education Sector

    ERIC Educational Resources Information Center

    Bandias, Susan; Fuller, Don; Larkin, Steven

    2014-01-01

    Important recent objectives of indigenous education policy in Australia have been aimed at redressing indigenous economic and social disadvantage through increasing student retention, progression and completion rates in both compulsory and post-compulsory education. The two sectors of the tertiary education system, vocational education and…

  4. Understanding Australian Aboriginal Tertiary Student Needs

    ERIC Educational Resources Information Center

    Oliver, Rhonda; Rochecouste, Judith; Bennell, Debra; Anderson, Roz; Cooper, Inala; Forrest, Simon; Exell, Mike

    2013-01-01

    Drawing from a study of the experiences of Australian Aboriginal and Torres Strait Islander university students, this paper presents an overview of the specific needs of these students as they enter and progress through their tertiary education. Extracts from a set of case studies developed from both staff and student interviews and an online…

  5. The Cretaceous/Tertiary Extinction Controversy.

    ERIC Educational Resources Information Center

    McCartney, Kevin

    1984-01-01

    The cause of the Cretaceous/Tertiary extinction has become a major geologic controversy. Current evidence for the two opposing views is reviewed to provide an introduction to the controversy and to form the basis for a seminar of discussion topic. (Author/JN)

  6. An Effective Preparation for Tertiary Mathematics

    ERIC Educational Resources Information Center

    Parnell, Sheena; Statham, Moira

    2007-01-01

    The University of Auckland offers a one-year pre-degree Tertiary Foundation Certificate (TFC) Programme, for up to 200 students who are under-prepared for university study. The students may come straight from school without having gained a university entrance qualification, or they may be students returning to education who lack the confidence to…

  7. IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (Etbe) ...

    EPA Pesticide Factsheets

    In September 2016, the U.S. Environmental Protection Agency's (USEPA) released the draft Integrated Risk Information System (IRIS) Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE). Consistent with the 2013 IRIS Enhancements, draft IRIS assessments are released prior to external peer review for a 60-day public comment period and discussed at an upcoming public science meeting. Accordingly, the toxicological review, supplementary information, and other materials pertaining to this draft assessment are posted on this site. This material is being released for public viewing and comment prior to a public meeting, providing an opportunity for the IRIS Program to engage in early discussions with stakeholders and the public on data that may be used to identify adverse health effects and characterize exposure-response relationships.

  8. Mid-tertiary ash flow tuff cauldrons, southwestern New Mexico

    NASA Technical Reports Server (NTRS)

    Elston, W. E.

    1984-01-01

    Characteristics of 28 known or suspected mid-Tertiary ash-flow tuff cauldrons in New Mexico are described. The largest region is 40 km in diameter, and erosional and block faulting processes have exposed levels as far down as the plutonic roots. The study supports a five-stage process: precursor, caldera collapse, early post-collapse, volcanism, major ring-fracture volcanism, and hydrothermal activity. The stages can repeat or the process can stop at any stage. Post-collapse lavas fell into two categories: cauldron lavas, derived from shallow defluidized residues of caldera-forming ash flow tuff eruption, and framework lavas, evolved from a siliceous pluton below the cauldron complex. The youngest caldera was shallow and formed from asymmetric subsidence and collapse of the caldera walls.

  9. Adolescent smoking and tertiary education: opposing pathways linking socio-economic background to alcohol consumption.

    PubMed

    Green, Michael J; Leyland, Alastair H; Sweeting, Helen; Benzeval, Michaela

    2016-08-01

    If socio-economic disadvantage is associated with more adolescent smoking, but less participation in tertiary education, and smoking and tertiary education are both associated with heavier drinking, these may represent opposing pathways to heavy drinking. This paper examines contextual variation in the magnitude and direction of these associations. Comparing cohort studies. United Kingdom. Participants were from the 1958 National Child Development Study (NCDS58; n = 15 672), the British birth cohort study (BCS70; n = 12 735) and the West of Scotland Twenty-07 1970s cohort (T07; n = 1515). Participants self-reported daily smoking and weekly drinking in adolescence (age 16 years) and heavy drinking (> 14/21 units in past week) in early adulthood (ages 22-26 years). Parental occupational class (manual versus non-manual) indicated socio-economic background. Education beyond age 18 was coded as tertiary. Models were adjusted for parental smoking and drinking, family structure and adolescent psychiatric distress. Respondents from a manual class were more likely to smoke and less likely to enter tertiary education (e.g. in NCDS58, probit coefficients were 0.201 and -0.765, respectively; P < 0.001 for both) than respondents from a non-manual class. Adolescent smokers were more likely to drink weekly in adolescence (0.346; P < 0.001) and more likely to drink heavily in early adulthood (0.178; P < 0.001) than adolescent non-smokers. Respondents who participated in tertiary education were more likely to drink heavily in early adulthood (0.110 for males, 0.182 for females; P < 0.001 for both) than respondents with no tertiary education. With some variation in magnitude, these associations were consistent across all three cohorts. In Britain, young adults are more likely to drink heavily both if they smoke and participate in tertiary education (college and university) despite socio-economic background being associated in opposite directions with these risk

  10. Diversification Management at Tertiary Education Level: A Review

    ERIC Educational Resources Information Center

    Takwate, Kwaji Tizhe

    2016-01-01

    This paper examines the concept of management of diversification at tertiary education level in view of the growth of national secondary education system which vested high scramble for tertiary education was made in relation to question of access and expansion. This paper examines management of diversification at tertiary education level as a…

  11. A multicentre, randomised controlled, non-inferiority trial, comparing nasal high flow with nasal continuous positive airway pressure as primary support for newborn infants with early respiratory distress born in Australian non-tertiary special care nurseries (the HUNTER trial): study protocol

    PubMed Central

    Manley, Brett J; Roberts, Calum T; Arnolda, Gaston R B; Wright, Ian M R; Owen, Louise S; Dalziel, Kim M; Foster, Jann P; Davis, Peter G; Buckmaster, Adam G

    2017-01-01

    Introduction Nasal high-flow (nHF) therapy is a popular mode of respiratory support for newborn infants. Evidence for nHF use is predominantly from neonatal intensive care units (NICUs). There are no randomised trials of nHF use in non-tertiary special care nurseries (SCNs). We hypothesise that nHF is non-inferior to nasal continuous positive airway pressure (CPAP) as primary support for newborn infants with respiratory distress, in the population cared for in non-tertiary SCNs. Methods and analysis The HUNTER trial is an unblinded Australian multicentre, randomised, non-inferiority trial. Infants are eligible if born at a gestational age ≥31 weeks with birth weight ≥1200 g and admitted to a participating non-tertiary SCN, are <24 hours old at randomisation and require non-invasive respiratory support or supplemental oxygen for >1 hour. Infants are randomised to treatment with either nHF or CPAP. The primary outcome is treatment failure within 72 hours of randomisation, as determined by objective oxygenation, apnoea or blood gas criteria or by a clinical decision that urgent intubation and mechanical ventilation, or transfer to a tertiary NICU, is required. Secondary outcomes include incidence of pneumothorax requiring drainage, duration of respiratory support, supplemental oxygen and hospitalisation, costs associated with hospital care, cost-effectiveness, parental stress and satisfaction and nursing workload. Ethics and dissemination Multisite ethical approval for the study has been granted by The Royal Children’s Hospital, Melbourne, Australia (Trial Reference No. 34222), and by each participating site. The trial is currently recruiting in eight centres in Victoria and New South Wales, Australia, with one previous site no longer recruiting. The trial results will be published in a peer-reviewed journal and will be presented at national and international conferences. Trial registration number Australian and New Zealand Clinical Trials Registry (ANZCTR

  12. The Wage Premium on Tertiary Education: New Estimates for 21 OECD Countries Countries. OECD Economics Department Working Papers, No. 589

    ERIC Educational Resources Information Center

    Strauss, Hubert; de la Maisonneuve, Christine

    2007-01-01

    This paper presents cross-section estimates of gross hourly wage premia on tertiary education. They are based on a unified framework for 21 OECD countries from the 1990s to the early 2000s and use international household surveys to maximise international comparability. The results of the "augmented" Mincerian wage equations point to an…

  13. The Professionalization of Educational Leaders through Postgraduate Study and Professional Development Opportunities in New Zealand Tertiary Education Institutions

    ERIC Educational Resources Information Center

    Macpherson, Reynold

    2010-01-01

    This paper reports a review of the professionalization services in educational leadership available from New Zealand's tertiary institutions at a time of accelerating retirements and turnover. Case studies of current programs identified six urgent policy issues: the need for research-based provisions in early childhood education (ECE); potential…

  14. Coupling in the absence of tertiary amines.

    PubMed

    Bodanszky, M; Bednarek, M A; Bodanszky, A

    1982-10-01

    In order to avoid base catalyzed side reactions during coupling, attempts were made to render superfluous the addition of tertiary amines to the reaction mixture. Weak acids were applied for the removal of acid labile protecting groups. Acetic acid and other carboxylic acids were considered unsuitable for this purpose coupling step. Pentachlorophenol and 2,4-dinitrophenol cleaved the Bpoc, Nps and Trt groups but more practical rates were reached with solutions of 1-hydroxybenzotriazole (HOBt) in trifluoroethanol, in acetic acid, or in a mixture of phenol and p-cresol. In addition to acidolysis, HOBt salts of amino components could also be obtained through hydrogenolysis of the Z group or thiolysis of the Nps group in the presence of HOBt, or by the displacement of acetic acid from acetate salts with HOBt. Acylation of HOBt salts of amino components with symmetrical or mixed anhydrides or with active esters did not require the addition of tertiary amine.

  15. The Tertiary and Quaternary pectens of California

    Arnold, Ralph

    1906-01-01

    This paper consists of two parts. The first is a brief outline of the different Tertiary and Pleistocene formations of California, giving the type localities, where, when, and by whom first described, their salient characters, where they and their supposed equiyalents are known to occur, the species of Pecten found in them, and their typical fauna as far as known. The second is devoted to the description and illustration of all of the known Tertiary, Pleistocene, and Recent Pectens of the western coast of North America from Alaska to and including the Gulf of California. With the description of each species is also given an account of its geologic and geographic range and, where practicable, its associated fauna.

  16. Alcohol consumption in tertiary education students.

    PubMed

    Reavley, Nicola J; Jorm, Anthony F; McCann, Terence V; Lubman, Dan I

    2011-07-09

    Heavy alcohol consumption among adolescents and young adults is an issue of significant public concern. With approximately 50% of young people aged 18-24 attending tertiary education, there is an opportunity within these settings to implement programs that target risky drinking. The aim of the current study was to survey students and staff within a tertiary education institution to investigate patterns of alcohol use, alcohol-related problems, knowledge of current National Health and Medical Research Council (NHMRC) guidelines for alcohol consumption and intentions to seek help for alcohol problems. Students of an Australian metropolitan university (with staff as a comparison group) participated in a telephone interview. Questions related to knowledge of NHMRC guidelines, drinking behaviour, alcohol-related problems and help-seeking intentions for alcohol problems. Level of psychological distress was also assessed. Of the completed interviews, 774 (65%) were students and 422 (35%) were staff. While staff were more likely to drink regularly, students were more likely to drink heavily. Alcohol consumption was significantly higher in students, in males and in those with a history of earlier onset drinking. In most cases, alcohol-related problems were more likely to occur in students. The majority of students and staff had accurate knowledge of the current NHMRC guidelines, but this was not associated with lower levels of risky drinking. Psychological distress was associated with patterns of risky drinking in students. Our findings are consistent with previous studies of tertiary student populations, and highlight the disconnect between knowledge of relevant guidelines and actual behaviour. There is a clear need for interventions within tertiary education institutions that promote more effective means of coping with psychological distress and improve help-seeking for alcohol problems, particularly among young men.

  17. Eclipsing Binaries with Possible Tertiary Components

    NASA Astrophysics Data System (ADS)

    Snyder, LeRoy F.

    2013-05-01

    Many eclipsing binary star systems (EBS) show long-term variations in their orbital periods which are evident in their O-C (observed minus calculated period) diagrams. This research carried out an analysis of 324 eclipsing binary systems taken from the systems analyzed in the Bob Nelson's O-C Files database. Of these 18 systems displayed evidence of periodic variations of the arrival times of the eclipses. These rates of period changes are sinusoidal variations. The sinusoidal character of these variations is suggestive of Keplerian motion caused by an orbiting companion. The reason for these changes is unknown, but mass loss, apsidal motion, magnetic activity and the presence of a third body have been proposed. This paper has assumed light time effect as the cause of the sinusoidal variations caused by the gravitational pull of a tertiary companion orbiting around the eclipsing binary systems. An observed minus calculated (O-C) diagram of the 324 systems was plotted using a quadratic ephemeris to determine if the system displayed a sinusoidal trend in theO-C residuals. After analysis of the 18 systems, seven systems, AW UMa, BB PEG, OO Aql, V508 Oph, VW Cep, WCrv and YY ERI met the benchmark of the criteria of a possible orbiting companion. The other 11 systems displayed a sinusoidal variation in the O-C residuals of the primary eclipses but these systems in the Bob Nelson's O-C Files did not contain times of minimum (Tmin) of the secondary eclipses and therefore not conclusive in determining the presents of the effects of a tertiary companion. An analysis of the residuals of the seven systems yields a light-time semi-amplitude, orbital period, eccentricity and mass of the tertiary companion as the amplitude of the variation is proportional to the mass, period and inclination of the 3rd orbiting body. Knowing the low mass of the tertiary body in the seven cases the possibility of five of these tertiary companions being brown dwarfs is discussed.

  18. Gestational Trophoblastic Disease - Clinicopathological Study at Tertiary Care Hospital

    PubMed Central

    Aher, Vidhya; Gadhiya, Suchi; Jagtap, Swati Sunil

    2017-01-01

    Introduction Gestational Trophoblastic Disease (GTD) is a term used for a group of pregnancy-related tumours. These consist of various tumours and tumour like lesions characterized by proliferation of trophoblastic tissue. Amongst GTD, hydatidiform moles are the most common form. These lesions sometimes may develop into invasive moles, or, in rare cases, into choriocarcinoma. Aim To study the clinicopathologic characteristics and prevalence of different forms of gestational trophoblastic disease in a tertiary care hospital. Materials and Methods The present study was descriptive, observational, analytical type done in Department of Pathology at tertiary care hospital from May 2012 to April 2016. All cases clinically suspected of GTD were included and confirmation was done by histopathological study on H&E stained slides. The cases of GTD were classified according to WHO classification. Detailed histomorphological features and beta human Chorionic Gonadotropin (hCG) levels were correlated. Results During study period, 18345 deliveries were reported; out of which 77 cases were diagnosed as GTD. Almost 97.40% cases were of hydatidiform moles, 1.30% cases of choriocarcinoma and 1.30% cases of Placental Site Trophoblastic Tumour (PSTT). Among the cases of hydatidiform mole 57.34% were complete mole and 41.33% cases were of partial mole. The common clinical presentation was per vaginal bleeding and amenorrhea. The blood group A was most commonly observed in patient (49.35%). In majority of cases beta hCG levels were between 50,000 to 100000 mIU/ml. The correlation between beta hCG level and GTD were done. Conclusion Pregnant females clinically presenting with abnormal vaginal bleeding must be evaluated for GTD. Histopathological examination is helpful for confirmatory diagnosis. Follow up of such patients is essential for early detection of malignant trophoblastic tumours. PMID:28969138

  19. Leaf Assemblages across the Cretaceous-Tertiary Boundary in the Raton Basin, New Mexico and Colorado

    NASA Astrophysics Data System (ADS)

    Wolfe, Jack A.; Upchurch, Garland R., Jr.

    1987-08-01

    Analyses of leaf megafossil and dispersed leaf cuticle assemblages indicate that major ecologic disruption and high rates of extinction occurred in plant communities at the Cretaceous-Tertiary boundary in the Raton Basin. In diversity increase, the early Paleocene vegetational sequence mimics normal short-term ecologic succession, but on a far longer time scale. No difference can be detected between latest Cretaceous and early Paleocene temperatures, but precipitation markedly increased at the boundary. Higher survival rate of deciduous versus evergreen taxa supports occurrence of a brief cold interval (<1 year), as predicted in models of an “impact winter.”

  20. A multicentre, randomised controlled, non-inferiority trial, comparing nasal high flow with nasal continuous positive airway pressure as primary support for newborn infants with early respiratory distress born in Australian non-tertiary special care nurseries (the HUNTER trial): study protocol.

    PubMed

    Manley, Brett J; Roberts, Calum T; Arnolda, Gaston R B; Wright, Ian M R; Owen, Louise S; Dalziel, Kim M; Foster, Jann P; Davis, Peter G; Buckmaster, Adam G

    2017-06-23

    Nasal high-flow (nHF) therapy is a popular mode of respiratory support for newborn infants. Evidence for nHF use is predominantly from neonatal intensive care units (NICUs). There are no randomised trials of nHF use in non-tertiary special care nurseries (SCNs). We hypothesise that nHF is non-inferior to nasal continuous positive airway pressure (CPAP) as primary support for newborn infants with respiratory distress, in the population cared for in non-tertiary SCNs. The HUNTER trial is an unblinded Australian multicentre, randomised, non-inferiority trial. Infants are eligible if born at a gestational age ≥31 weeks with birth weight ≥1200 g and admitted to a participating non-tertiary SCN, are <24 hours old at randomisation and require non-invasive respiratory support or supplemental oxygen for >1 hour. Infants are randomised to treatment with either nHF or CPAP. The primary outcome is treatment failure within 72 hours of randomisation, as determined by objective oxygenation, apnoea or blood gas criteria or by a clinical decision that urgent intubation and mechanical ventilation, or transfer to a tertiary NICU, is required. Secondary outcomes include incidence of pneumothorax requiring drainage, duration of respiratory support, supplemental oxygen and hospitalisation, costs associated with hospital care, cost-effectiveness, parental stress and satisfaction and nursing workload. Multisite ethical approval for the study has been granted by The Royal Children's Hospital, Melbourne, Australia (Trial Reference No. 34222), and by each participating site. The trial is currently recruiting in eight centres in Victoria and New South Wales, Australia, with one previous site no longer recruiting. The trial results will be published in a peer-reviewed journal and will be presented at national and international conferences. Australian and New Zealand Clinical Trials Registry (ANZCTR): ACTRN12614001203640; pre-results. © Article author(s) (or their employer(s) unless

  1. Pylephlebitis: incidence and prognosis in a tertiary hospital.

    PubMed

    Belhassen-García, Moncef; Gomez-Munuera, Mercedes; Pardo-Lledias, Javier; Velasco-Tirado, Virginia; Perez-Persona, Ernesto; Galindo-Perez, Inmaculada; Alvela-Suárez, Lucia; Romero-Alegría, Angela; Muñoz-Bellvis, Luis; Cordero-Sánchez, Miguel

    2014-01-01

    Septic thrombophlebitis of the portal vein or its branches, most often secondary to intra-abdominal infection is known as pylephlebitis. The frequency and the prognosis of this complication are unknown. The aim of this study was to determine the global and relative incidence of the most frequent intra-abdominal infections and the real prognosis of this disease. An observational retrospective study was conducted in a tertiary care hospital (University Hospital of Salamanca, Spain) from January 1999 to December 2008. A total of 7796 patients with intra-abdominal infection were evaluated, of whom 13 (0.6%) had been diagnosed with pylephlebitis. Diverticulitis was the most frequent underlying process, followed by biliary infection. Early mortality was 23%. Survivors had no recurrences, but one of them developed portal cavernomatosis. Pylephlebitis is a rare complication of intra-abdominal infection, with a high early mortality, but with a good prognosis for survivors. Copyright © 2013 Elsevier España, S.L. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  2. Management for the children with otitis media with effusion in the tertiary hospital.

    PubMed

    Choung, Yun-Hoon; Shin, You Ree; Choi, Seong Jun; Park, Keehyun; Park, Hun Yi; Lee, Jong Bin; Han, Dong Hee; Kahng, Hison

    2008-12-01

    Recently, new evidence-based recommendations have been introduced for diagnosing and managing otitis media with effusion (OME) in children. However, there are some difficulties to follow the general guidelines in the tertiary hospitals. The purpose is to evaluate the efficiency of antibiotics or antihistamines for treatment of children with OME in the tertiary hospital with a randomized prospective clinical study. Eighty-four children with OME who had been diagnosed in the tertiary hospital were randomized to receive 5 different medications for 2 weeks. We prescribed antibiotics (amoxicillin-clavulanate syrup) in Group I (n=16), antibiotics/steroids (prednisolone) in Group II (n=18), antibiotics/antihistamines (ebastine) in Group III (n=15), antibiotics/steroids/antihistamines in Group IV (n=17), and mucolytics (ivy leaf extract) in Group V (n=17) for control. We followed-up children every 2 weeks and evaluated the state of OME at 3 months. Thirty six (42.9%) of 84 children were resolved within average 6.9 weeks after the treatments. Thirty-six (42.9%) were treated with ventilation tube insertion and 12 patients (14.3%) were observed. There was no difference in the resolution rates of OME among the five different protocols (P>0.05). There was no difference in the resolution rates among groups who used steroids, antihistamines, steroids and antihistamines, or other medications to manage 42 children with allergies (P>0.05). In the tertiary hospital, the cure rate of children with OME was not as high as well-known, and antibiotics or anti-allergic medications were not more effective than control. We may, therefore, need any other guidelines which are different from the previous evidence-based recommendations, including early operation in the tertiary hospitals.

  3. Stereoinversion of tertiary alcohols to tertiary-alkyl isonitriles and amines.

    PubMed

    Pronin, Sergey V; Reiher, Christopher A; Shenvi, Ryan A

    2013-09-12

    The SN2 reaction (bimolecular nucleophilic substitution) is a well-known chemical transformation that can be used to join two smaller molecules together into a larger molecule or to exchange one functional group for another. The SN2 reaction proceeds in a very predictable manner: substitution occurs with inversion of stereochemistry, resulting from the 'backside attack' of the electrophilic carbon by the nucleophile. A significant limitation of the SN2 reaction is its intolerance for tertiary carbon atoms: whereas primary and secondary alcohols are viable precursor substrates, tertiary alcohols and their derivatives usually either fail to react or produce stereochemical mixtures of products. Here we report the stereochemical inversion of chiral tertiary alcohols with a nitrogenous nucleophile facilitated by a Lewis-acid-catalysed solvolysis. The method is chemoselective against secondary and primary alcohols, thereby complementing the selectivity of the SN2 reaction. Furthermore, this method for carbon-nitrogen bond formation mimics a putative biosynthetic step in the synthesis of marine terpenoids and enables their preparation from the corresponding terrestrial terpenes. We expect that the general attributes of the methodology will allow chiral tertiary alcohols to be considered viable substrates for stereoinversion reactions.

  4. Pregnancy of unknown location: Outcome in a tertiary care hospital.

    PubMed

    Amer, Nuzhat; Amer, Muhammad; Kolkaila, Mohamed Abdoh; Yaqoob, Shahida

    2015-10-01

    To find out the outcome of a cohort of women with pregnancy of unknown location presenting to a tertiary care hospital. The prospective study was conducted from January to December, 2011, at Early Pregnancy Assessment Unit, King Faisal Military Hospital, Khamis Mushait, Saudi Arabia. Data was collected for women with early pregnancy or with history of amenorrhoea, bleeding or pain. These women were investigated with serum beta-human chorionic gonadotrophin levels twice weekly and transvaginal ultrasonography weekly. Expectant management was done for failing pregnancy of unknown location while medical or surgical management was considered for persistent pregnancy of unknown location and ectopic pregnancy. During study period, 7215 patients were admitted, and, of them, 2212(30.6%) were patients with early pregnancy. Meeting the inclusion criteria were 183(2.53%) patients who formed the study sample. There were 131(71.6%) patients presenting with amenorrhoea, 90(49.2%) had bleeding and 93(50.8%) presented with pain. Outcome of 100(54.6%) patients was failing pregnancy of unknown location, 58(31.7%) had intrauterine pregnancy, 14(7.7%) converted to ectopic pregnancy, while 11(6%) had persistent pregnancy of unknown location. All patients with persistent pregnancy of unknown location and 5(36%) patients with ectopic pregnancy were medically treated. Five (36%) patients having ectopic pregnancy were managed surgically. Management of choice for asymptomatic patients having pregnancy of unknown location is expectant management. Most of the patients suspected to have Most of the patients with persistent pregnancy of unknown location and ectopic pregnancy can be managed medically.

  5. Towards the 21st Century. Facilities for Tertiary Education.

    ERIC Educational Resources Information Center

    Corbett, Anne, Ed.

    This report presents observations of experts in planning, design, construction or management of tertiary educational facilities about the emerging issues and the appropriate planning and architectural solutions for higher education facilities as the new millennium approaches. Specific topics discuss the current context of tertiary education…

  6. Crime and Crime Management in Nigeria Tertiary Institutions

    ERIC Educational Resources Information Center

    Adebanjo, Margaret Adewunmi

    2014-01-01

    This paper examines crime and its management in Nigerian tertiary institutions. Tertiary institutions today have become arenas for crime activities such as rape, cultism, murder, theft, internet fraud, drug abuse, and examination malpractices. This paper delves into what crime is, and its causes; and the positions of the law on crime management.…

  7. 10 CFR 212.78 - Tertiary incentive crude oil.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Tertiary incentive crude oil. 212.78 Section 212.78 Energy DEPARTMENT OF ENERGY OIL MANDATORY PETROLEUM PRICE REGULATIONS Producers of Crude Oil § 212.78 Tertiary incentive crude oil. Annual prepaid expenses report. By January 31 of each year after 1980, the project...

  8. 10 CFR 212.78 - Tertiary incentive crude oil.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Tertiary incentive crude oil. 212.78 Section 212.78 Energy DEPARTMENT OF ENERGY OIL MANDATORY PETROLEUM PRICE REGULATIONS Producers of Crude Oil § 212.78 Tertiary incentive crude oil. Annual prepaid expenses report. By January 31 of each year after 1980, the project...

  9. 10 CFR 212.78 - Tertiary incentive crude oil.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Tertiary incentive crude oil. 212.78 Section 212.78 Energy DEPARTMENT OF ENERGY OIL MANDATORY PETROLEUM PRICE REGULATIONS Producers of Crude Oil § 212.78 Tertiary incentive crude oil. Annual prepaid expenses report. By January 31 of each year after 1980, the project...

  10. Diversification of Tertiary Education in Norway, Case Study.

    ERIC Educational Resources Information Center

    Ottosen, Kristian

    The educational system of Norway, which is organized into primary, secondary and higher education, is reviewed. Types of schools and/or courses in secondary education are listed including present enrollment figures by main types of secondary education and transfer rates of secondary to tertiary education. The system of tertiary education is…

  11. Evaluation of the Special Tertiary Admissions Test (STAT)

    ERIC Educational Resources Information Center

    Coates, Hamish; Friedman, Tim

    2010-01-01

    This paper reports findings from the first national Australian study of the predictive validity of the Special Tertiary Admissions Test (STAT). Background on tertiary admissions procedures in Australia is presented, followed by information on STAT and the research methods. The results affirm that STAT, through the provision of baseline and…

  12. The Impediments Facing Community Engagement in Omani Educational Tertiary Institutions

    ERIC Educational Resources Information Center

    Issa, Jinan Hatem

    2016-01-01

    Prior to the vital role that social capital plays in accomplishing prosperity for any educational tertiary institution, it was emphasised in several countries' agendas, including the Sultanate of Oman. This study endeavours to explore the impediments facing the enhancement of the social capital in Omani educational tertiary institutions through…

  13. 10 CFR 212.78 - Tertiary incentive crude oil.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... operator with respect to any enhanced oil recovery project for which a report had been filed previously... 10 Energy 3 2010-01-01 2010-01-01 false Tertiary incentive crude oil. 212.78 Section 212.78 Energy DEPARTMENT OF ENERGY OIL MANDATORY PETROLEUM PRICE REGULATIONS Producers of Crude Oil § 212.78 Tertiary...

  14. An Exploratory Study of Collaboration in New Zealand Tertiary Libraries

    ERIC Educational Resources Information Center

    Finnerty, Colleen

    2005-01-01

    The shift in policy from market driven behaviour towards a more cooperative tertiary sector is having an effect on New Zealand academic libraries and their relationships. Despite this, there has been no investigation of collaboration specifically targeting New Zealand tertiary libraries. This research project examine the state of collaboration…

  15. Tertiary Education Policy in Ghana. An Assessment: 1988-1998.

    ERIC Educational Resources Information Center

    Girdwood, Alison

    This study was one of several activities conducted at the end of a 5-year World Bank/Government of Ghana project, the Tertiary Education Project (TEP). This project was designed to assist the government of Ghana with the restructuring and quality enhancement of its tertiary education sector. Although the government had prepared an ambitious reform…

  16. Employee Engagement and Performance of Lecturers in Nigerian Tertiary Institutions

    ERIC Educational Resources Information Center

    Agbionu, Uchenna Clementina; Anyalor, Maureen; Nwali, Anthony Chukwuma

    2018-01-01

    The study investigated employee engagement and performance of lecturers in Nigerian Tertiary Institutions. It employed descriptive and correlation research designs. Stratified random sampling was used to select three tertiary institutions in Nigeria and the sample size of 314 lecturers was obtained through Taro Yamane. Questionnaires were…

  17. Xeroderma pigmentosum at a tertiary care center in Saudi Arabia.

    PubMed

    Alwatban, Lenah; Binamer, Yousef

    2017-01-01

    Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder caused by defective DNA repair that results in extreme sensitivity to ultraviolet (UV) rays. Depending on the type of XP, the disease may affect the skin, eyes and nervous system. Describe the dermatologic manifestations in patients suffering from XP. Retrospective, descriptive review of medical records. Dermatology clinic at tertiary care center in Riyadh. This study included Saudi patients with clinically confirmed XP. Demographic and clinical data including pathology and associated conditions and outcomes. Of 21 patients with XP, the most common manifestation was lentigines, affecting 18 patients (86%). The most common skin cancer was basal cell carcinoma followed by squamous cell carcinoma (SCC) affecting 15 (71.4%) and 9 (42.8%), respectively. Other skin findings included neurofibroma, trichilemmoma and seborrheic keratosis. Ocular involvement included photophobia, which was the most common finding followed by dryness and ocular malignancies. Two patients showed neurological involvement, which correlated with the type of mutation. Considering that XP is a rare genetic disease, this description of our patient population will aid in early recognition and diagnosis. Retrospective and small number of patients. Genetic analyses were done for only 5 of the 21 patients.

  18. Tertiary lymphoid structures in cancer and beyond.

    PubMed

    Dieu-Nosjean, Marie-Caroline; Goc, Jérémy; Giraldo, Nicolas A; Sautès-Fridman, Catherine; Fridman, Wolf Herman

    2014-11-01

    Tertiary lymphoid structures (TLS) are ectopic lymphoid formations found in inflamed, infected, or tumoral tissues. They exhibit all the characteristics of structures in the lymph nodes (LN) associated with the generation of an adaptive immune response, including a T cell zone with mature dendritic cells (DC), a germinal center with follicular dendritic cells (FDC) and proliferating B cells, and high endothelial venules (HEV). In this review, we discuss evidence for the roles of TLS in chronic infection, autoimmunity, and cancer, and address the question of whether TLS present beneficial or deleterious effects in these contexts. We examine the relationship between TLS in tumors and patient prognosis, and discuss the potential role of TLS in building and/or maintaining local immune responses and how this understanding may guide therapeutic interventions. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Aqueous flooding methods for tertiary oil recovery

    DOEpatents

    Peru, Deborah A.

    1989-01-01

    A method of aqueous flooding of subterranean oil bearing formation for tertiary oil recovery involves injecting through a well into the formation a low alkaline pH aqueous sodium bicarbonate flooding solution. The flooding solution's pH ranges from about 8.25 to 9.25 and comprises from 0.25 to 5 weight percent and preferably about 0.75 to 3.0 weight percent of sodium bicarbonate and includes a petroleum recovery surfactant of 0.05 to 1.0 weight percent and between 1 and 20 weight percent of sodium chloride. After flooding, an oil and water mixture is withdrawn from the well and the oil is separated from the oil and water mixture.

  20. Cretaceous-Tertiary findings, paradigms and problems

    NASA Technical Reports Server (NTRS)

    Officer, C. B.; Drake, C. L.

    1988-01-01

    The asteroid hypothesis has stimulated numerous studies of the paleontological record at Cretaceous/Tertiary time as well as of geological indicators of environmental crisis preserved in the rock record. Both extinctions and geological anomalies often occur at times that do not appear to be synchronous or instantaneous. The record includes paleontological indicators of dinosaurs, terrestrial flora, marine planktonic organisms, and shallow water marine macrofauna and geological phenomena include occurrences of iridium and other platinum metals, trace elements, clay mineralogy, shocked minerals, soot, microspherules, and isotopes of osmium, strontium and carbon. These findings are reviewed in the context of the alternate hypotheses of an exogenic cause, involving either a single asteroid impact or multiple commentary impacts, and an endogenic cause, involving intense global volcanism and major sea level regression.

  1. 'Tertiary' nuclear burning - Neutron star deflagration?

    NASA Technical Reports Server (NTRS)

    Michel, F. Curtis

    1988-01-01

    A motivation is presented for the idea that dense nuclear matter can burn to a new class of stable particles. One of several possibilities is an 'octet' particle which is the 16 baryon extension of alpha particle, but now composed of a pair of each of the two nucleons, (3Sigma, Delta, and 2Xi). Such 'tertiary' nuclear burning (here 'primary' is H-He and 'secondary' is He-Fe) may lead to neutron star explosions rather than collapse to a black hole, analogous to some Type I supernovae models wherein accreting white dwarfs are pushed over the Chandrasekhar mass limit but explode rather than collapse to form neutron stars. Such explosions could possibly give gamma-ray bursts and power quasars, with efficient particle acceleration in the resultant relativistic shocks. The new stable particles themselves could possibly be the sought-after weakly interacting, massive particles (WIMPs) or 'dark' matter.

  2. Global discourses and experiential speculation: Secondary and tertiary graduate Malawians dissect the HIV/AIDS epidemic

    PubMed Central

    2011-01-01

    Background Since the beginning of the HIV/AIDS epidemic, the perspectives of secondary and tertiary school graduates in sub-Saharan Africa regarding the effectiveness of government and international HIV/AIDS policies and programmes have not been thoroughly examined. When extensive monetary aid is directed toward "development" in a country like Malawi, it is the educated elites - secondary and tertiary graduates who are heavily involved and influential in the domestic re-distribution and implementation of millions of dollars worth of aid - on whom international expectations fall to decrease the transmission of HIV. Many Malawian jobs related to public health and HIV/AIDS are created as a direct result of this funding and are occupied by the few secondary and tertiary graduates. Thus, it is a practical venture to understand their perspectives on highly contentious and heavily funded HIV/AIDS issues that affect their nation. Methods Qualitative data was collected in this study in efforts to discover in-depth perspectives on the HIV/AIDS epidemic. Thirty-eight secondary and tertiary graduate Malawians took part in semi-structured interviews. Data was analysed using an early grounded theory approach and subsequent themes of "global discourses" and "experiential knowledge of HIV/AIDS" emerged. Results This group of Malawians frequently responded to questions regarding healthcare and access to medicine, sexual behaviours and methods of reducing the spread of HIV/AIDS by citing and explaining the widespread, international and "proper" responses. The secondary and tertiary graduate Malawians also discussed these same topics in terms of what they perceive or have experienced. Experiential responses, such as the counter-productivity of circumcision and condoms, the overestimation of HIV/AIDS prevalence, and calls for more authoritarian policing of commercial sex work, were remarkably divergent from the HIV/AIDS discourse. Conclusions The opinions of this group of secondary

  3. Global discourses and experiential speculation: Secondary and tertiary graduate Malawians dissect the HIV/AIDS epidemic.

    PubMed

    Myroniuk, Tyler W

    2011-10-04

    Since the beginning of the HIV/AIDS epidemic, the perspectives of secondary and tertiary school graduates in sub-Saharan Africa regarding the effectiveness of government and international HIV/AIDS policies and programmes have not been thoroughly examined. When extensive monetary aid is directed toward "development" in a country like Malawi, it is the educated elites - secondary and tertiary graduates who are heavily involved and influential in the domestic re-distribution and implementation of millions of dollars worth of aid - on whom international expectations fall to decrease the transmission of HIV. Many Malawian jobs related to public health and HIV/AIDS are created as a direct result of this funding and are occupied by the few secondary and tertiary graduates. Thus, it is a practical venture to understand their perspectives on highly contentious and heavily funded HIV/AIDS issues that affect their nation. Qualitative data was collected in this study in efforts to discover in-depth perspectives on the HIV/AIDS epidemic. Thirty-eight secondary and tertiary graduate Malawians took part in semi-structured interviews. Data was analysed using an early grounded theory approach and subsequent themes of "global discourses" and "experiential knowledge of HIV/AIDS" emerged. This group of Malawians frequently responded to questions regarding healthcare and access to medicine, sexual behaviours and methods of reducing the spread of HIV/AIDS by citing and explaining the widespread, international and "proper" responses. The secondary and tertiary graduate Malawians also discussed these same topics in terms of what they perceive or have experienced. Experiential responses, such as the counter-productivity of circumcision and condoms, the overestimation of HIV/AIDS prevalence, and calls for more authoritarian policing of commercial sex work, were remarkably divergent from the HIV/AIDS discourse. The opinions of this group of secondary and tertiary graduate Malawians do not

  4. Tertiary Excess of Fibroblast Growth Factor 23 and Hypophosphatemia Following Kidney Transplantation

    PubMed Central

    Seeherunvong, Wacharee; Wolf, Myles

    2010-01-01

    Hypophosphatemia due to inappropriate urinary phosphate wasting is a frequent metabolic complication of the early period following kidney transplantation. Although previously considered to be caused by tertiary hyperparathyroidism, recent evidence suggests a primary role for persistently elevated circulating levels of the phosphorus-regulating hormone, fibroblast growth factors 23 (FGF23). In the setting of a healthy renal allograft, markedly increased FGF23 levels from the dialysis period induce renal phosphate wasting and inhibition of calcitriol production, which contribute to hypophosphatemia. While such tertiary FGF23 excess and resultant hypophosphatemia typically abates within the first few weeks to months post-transplant, some recipients manifest persistent renal phosphate wasting. Furthermore, increased FGF23 levels have been associated with increased risk of kidney disease progression, cardiovascular disease and death outside of the transplant setting. Whether tertiary FGF23 excess is associated with adverse transplant outcomes is unknown. In this article, we review the physiology of FGF23, summarize its relationship with hypophosphatemia after kidney transplantation, and speculate on its potential impact on long term outcomes of renal allograft recipients. PMID:20946192

  5. Assessing uncertainty in outsourcing clinical services at tertiary health centers.

    PubMed

    Billi, John E; Pai, Chih-Wen; Spahlinger, David A

    2007-01-01

    When tertiary health centers face capacity constraint, one feasible strategy to meet service demand is outsourcing clinical services to qualified community providers. Clinical outsourcing enables tertiary health centers to meet the expectations of service timeliness and provides good opportunities to collaborate with other health care providers. However, outsourcing may result in dependence and loss of control for the tertiary health centers. Other parties involved in clinical outsourcing such as local partners, patients, and payers may also encounter potential risks as well as enjoy benefits in an outsourcing arrangement. Recommendations on selecting potential outsourcing partners are given to minimize the risks associated with an outsourcing contract. Copyright (c) 2006 John Wiley & Sons, Ltd.

  6. Mixed La-Li heterobimetallic complexes for tertiary nitroaldol resolution.

    PubMed

    Tosaki, Shin-ya; Hara, Keiichi; Gnanadesikan, Vijay; Morimoto, Hiroyuki; Harada, Shinji; Sugita, Mari; Yamagiwa, Noriyuki; Matsunaga, Shigeki; Shibasaki, Masakatsu

    2006-09-13

    A kinetic resolution of tertiary nitroaldols derived from simple ketones is described. Mixed BINOL/biphenol La-Li heterobimetallic complexes gave the best selectivity in retro-nitroaldol reactions of racemic tertiary nitroaldols. By using a mixture of La-Li3-(1a)3 complex (LLB 2a) and La-Li3-(1b)3 (LLB* 2b) complex in a ratio of 2/1, chiral tertiary nitroaldols were obtained in 80-97% ee and 30-47% recovery yield.

  7. Neuropsychology Within a Tertiary Care Epilepsy Center.

    PubMed

    Morrison, Chris E; MacAllister, William S; Barr, William B

    2018-05-01

    Epilepsy is a prevalent condition characterized by variations in its clinical presentation, etiology, and amenability to treatment. Through history, neuropsychologists have played a significant role in performing research studies on changes in language, memory, and executive functioning in patients with epilepsy, including those undergoing surgical treatment for medically refractory seizures. These studies provided a foundation for establishing neuropsychologists as critical members of interdisciplinary clinical teams specializing in evaluation and treatment of epilepsy. This article describes a number of elements of specialized neuropsychological practice that have evolved over the years within a tertiary care epilepsy center. Through diagnostic interview and objective testing, the neuropsychologist is able to provide a more complete and objective understanding of a patient's cognitive and behavioral functioning than what is obtained by other clinicians through brief office visits. While assessment of cognition, mood, and behavior is the most commonly provided service to patients with epilepsy from all age groups, there are many instances when neuropsychologists in surgical settings are called to perform more specialized procedures, including the intracarotid amytal (Wada) procedure, electrocortical stimulation mapping of language eloquent brain regions, and functional brain imaging procedures. While working as a neuropsychologist on an interdisciplinary epilepsy care team requires specialized knowledge and clinical training, it is extremely satisfying due to the diversity of the patient population and the particular challenges resulting from the often unique manner that cognition and behavior can be affected in patients with epilepsy across the lifespan.

  8. Aquatic Life Criteria - Methyl Tertiary-Butyl Ether (MTBE)

    EPA Pesticide Factsheets

    Information pertaining to the 1999 Acute and Chronic Ambient Aquatic Life Water Quality Criteria for Methyl Tertiary-Butyl Ether (MTBE) for freshwater and salt water. Information includes the safe levels of MTBE that should protect the majority of species.

  9. Facility Benchmarking Trends in Tertiary Education - An Australian Case Study.

    ERIC Educational Resources Information Center

    Fisher, Kenn

    2001-01-01

    Presents how Australia's facility managers are responding to the growing impact of tertiary education participation and the increase in educational facility usage. Topics cover strategic asset management and the benchmarking of education physical assets and postsecondary institutions. (GR)

  10. DIRECT SYNTHESIS OF TERTIARY AMINES IN WATER USING MICROWAVES

    EPA Science Inventory

    A direct synthesis of tertiary amines is presented that proceeds expeditiously via N-alkylation of amines using alkyl halides in alkaline aqueous medium. This environmentally benign reaction is accelerated upon exposure to microwave irradiation resulting in shortened reaction tim...

  11. An atmospheric pCO2 reconstruction across the Cretaceous-Tertiary boundary from leaf megafossils

    PubMed Central

    Beerling, D. J.; Lomax, B. H.; Royer, D. L.; Upchurch, G. R.; Kump, L. R.

    2002-01-01

    The end-Cretaceous mass extinctions, 65 million years ago, profoundly influenced the course of biotic evolution. These extinctions coincided with a major extraterrestrial impact event and massive volcanism in India. Determining the relative importance of each event as a driver of environmental and biotic change across the Cretaceous-Tertiary boundary (KTB) crucially depends on constraining the mass of CO2 injected into the atmospheric carbon reservoir. Using the inverse relationship between atmospheric CO2 and the stomatal index of land plant leaves, we reconstruct Late Cretaceous-Early Tertiary atmospheric CO2 concentration (pCO2) levels with special emphasis on providing a pCO2 estimate directly above the KTB. Our record shows stable Late Cretaceous/Early Tertiary background pCO2 levels of 350–500 ppm by volume, but with a marked increase to at least 2,300 ppm by volume within 10,000 years of the KTB. Numerical simulations with a global biogeochemical carbon cycle model indicate that CO2 outgassing during the eruption of the Deccan Trap basalts fails to fully account for the inferred pCO2 increase. Instead, we calculate that the postboundary pCO2 rise is most consistent with the instantaneous transfer of ≈4,600 Gt C from the lithic to the atmospheric reservoir by a large extraterrestrial bolide impact. A resultant climatic forcing of +12 W⋅m−2 would have been sufficient to warm the Earth's surface by ≈7.5°C, in the absence of counter forcing by sulfate aerosols. This finding reinforces previous evidence for major climatic warming after the KTB impact and implies that severe and abrupt global warming during the earliest Paleocene was an important factor in biotic extinction at the KTB. PMID:12060729

  12. Predicting loop–helix tertiary structural contacts in RNA pseudoknots

    PubMed Central

    Cao, Song; Giedroc, David P.; Chen, Shi-Jie

    2010-01-01

    Tertiary interactions between loops and helical stems play critical roles in the biological function of many RNA pseudoknots. However, quantitative predictions for RNA tertiary interactions remain elusive. Here we report a statistical mechanical model for the prediction of noncanonical loop–stem base-pairing interactions in RNA pseudoknots. Central to the model is the evaluation of the conformational entropy for the pseudoknotted folds with defined loop–stem tertiary structural contacts. We develop an RNA virtual bond-based conformational model (Vfold model), which permits a rigorous computation of the conformational entropy for a given fold that contains loop–stem tertiary contacts. With the entropy parameters predicted from the Vfold model and the energy parameters for the tertiary contacts as inserted parameters, we can then predict the RNA folding thermodynamics, from which we can extract the tertiary contact thermodynamic parameters from theory–experimental comparisons. These comparisons reveal a contact enthalpy (ΔH) of −14 kcal/mol and a contact entropy (ΔS) of −38 cal/mol/K for a protonated C+•(G–C) base triple at pH 7.0, and (ΔH = −7 kcal/mol, ΔS = −19 cal/mol/K) for an unprotonated base triple. Tests of the model for a series of pseudoknots show good theory–experiment agreement. Based on the extracted energy parameters for the tertiary structural contacts, the model enables predictions for the structure, stability, and folding pathways for RNA pseudoknots with known or postulated loop–stem tertiary contacts from the nucleotide sequence alone. PMID:20100813

  13. Tertiary and Quaternary tectonic faulting in southernmost Illinois

    Nelson, W.J.; Denny, F.B.; Devera, J.A.; Follmer, L.R.; Masters, J.M.

    1997-01-01

    Tertiary and/or Quaternary tectonic faulting is documented in three areas of southernmost Illinois: the Fluorspar Area Fault Complex (FAFC) in Pope and Massac Counties, the Ste. Genevieve Fault Zone (SGFZ) in Alexander and Union Counties, and the Commerce Fault Zone (CFZ) in Alexander County. In the FAFC, faults that strike NE and NNE displace Mounds Gravel (late Miocene to early Pleistocene) and, locally, the Metropolis terrace gravel (Pleistocene; pre-Woodfordian). No Woodfordian or younger deposits are deformed. Faults typically outline narrow, linear grabens that formed under tension with a component of strike slip. North-south to NW-trending vertical faults near the southeast end of the SGFZ displace Eocene sediments. Again, faults outline narrow grabens and show indications of strike slip. Deformed Quaternary sediments have not been observed. The CFZ, which trends northeast, displaces Mounds Gravel in Illinois and units as young as Peoria Silt (Woodfordian) in Missouri. Quaternary movement has been interpreted as right-lateral strike-slip. The CFZ coincides with a subtle gravity and magnetic lineament and seems to reflect a major feature in the basement. Surface expression in Illinois is subtle, but mafic and ultramafic intrusions, hydrothermal alteration and small faults align with the Commerce geophysical lineament. Earthquake foci in Missouri and Illinois lie on or close to the CFZ; some focal mechanisms fit the fault trend. Among these structures, only the CFZ exhibits slip that conforms to the current stress field (principal compressive stress axis E-W to ENE-WSW). Possibly, the stress field changed during Neogene time. Alternatively, high fluid pressures or local stress concentrations may have induced slip on less favorably oriented fractures. Tighter constraints are needed on timing, magnitude, and direction of Neogene displacement. ?? 1997 Elsevier Science B.V.

  14. Hearing Screening in a Tertiary Care Hospital in India

    PubMed Central

    Shah, Neha; Patel, Kalpesh B.; Vishwakarma, Rajesh

    2015-01-01

    Introduction: To study the incidence of hearing loss among children and to determine and confirm the distribution of common risk factors in children with hearing loss presenting at a tertiary care hospital in India. Materials and Methods: Babies underwent hearing screening using Transient Evoked Otoacoustic Emission (TEOAE) and Automated Auditory Brainstem Response (AABR) from November 2009 to September 2011. It was a cross-sectional study carried out at our institute involving 500 babies (≤2 y). To identify the high risk babies, Joint Committee on Infant Hearing (2007) High risk registry was used. Results: In our study 110 (22%) babies belonged to high risk category and 11(2.2%) of total screened babies had significant hearing loss. Total number of babies who passed the initial screening with TEOAE was 284 (56.8%). On diagnostic AABR screening of TEOAE REFERRED babies, the babies with no risk factor showed normal AABR tracings whereas from among those with one or multiple risk factors (110 babies), 11(10%) showed different levels of hearing impairment. Hearing loss was highly associated with Neonatal Intensive Care Unit (NICU) admission i.e. 8/11(72.7%), followed by Low Birth Weight (LBW) and hypoxia (6/11 i.e. 54.5% each). Conclusion: Hearing loss is more common in those babies with risk factors (majority being NICU admission, LBW and hypoxia). OAE and ABR screening of infants at risk for significant hearing loss is a clinically efficient and cost effective approach for early detection of significant hearing loss. PMID:25954639

  15. Tertiary model of a plant cellulose synthase

    PubMed Central

    Sethaphong, Latsavongsakda; Haigler, Candace H.; Kubicki, James D.; Zimmer, Jochen; Bonetta, Dario; DeBolt, Seth; Yingling, Yaroslava G.

    2013-01-01

    A 3D atomistic model of a plant cellulose synthase (CESA) has remained elusive despite over forty years of experimental effort. Here, we report a computationally predicted 3D structure of 506 amino acids of cotton CESA within the cytosolic region. Comparison of the predicted plant CESA structure with the solved structure of a bacterial cellulose-synthesizing protein validates the overall fold of the modeled glycosyltransferase (GT) domain. The coaligned plant and bacterial GT domains share a six-stranded β-sheet, five α-helices, and conserved motifs similar to those required for catalysis in other GT-2 glycosyltransferases. Extending beyond the cross-kingdom similarities related to cellulose polymerization, the predicted structure of cotton CESA reveals that plant-specific modules (plant-conserved region and class-specific region) fold into distinct subdomains on the periphery of the catalytic region. Computational results support the importance of the plant-conserved region and/or class-specific region in CESA oligomerization to form the multimeric cellulose–synthesis complexes that are characteristic of plants. Relatively high sequence conservation between plant CESAs allowed mapping of known mutations and two previously undescribed mutations that perturb cellulose synthesis in Arabidopsis thaliana to their analogous positions in the modeled structure. Most of these mutation sites are near the predicted catalytic region, and the confluence of other mutation sites supports the existence of previously undefined functional nodes within the catalytic core of CESA. Overall, the predicted tertiary structure provides a platform for the biochemical engineering of plant CESAs. PMID:23592721

  16. Neonatal exchange transfusions in tertiary and non-tertiary hospital settings, New South Wales, 2001-2012.

    PubMed

    Chessman, Julia C; Bowen, Jennifer R; Ford, Jane B

    2017-05-01

    To describe neonatal exchange transfusions in New South Wales (NSW) before and after release in January 2007 of a NSW Health guideline regarding exchange transfusions in tertiary and non-tertiary hospitals. The study population included neonates receiving exchange transfusion in NSW hospitals, 2001-2012. Linked birth and hospital data for mothers and babies were used to describe birth characteristics and maternal and neonatal conditions. Exchange transfusions were identified in hospital data and compared for 2001-2006 and 2007-2012. Maternal and neonatal characteristics were compared with χ 2 and Wilcoxon signed-rank tests. Between 2001 and 2012, there were 286 exchange transfusions performed for 281 neonates in NSW hospitals. The number of exchange transfusions decreased from 187 in 184 neonates for 2001-2006 to 99 in 97 neonates 2007-2012 (P < 0.001). The percentage of exchange transfusions performed at tertiary hospitals increased from 85% in 2001-2006 to 91% in 2007-2012, although this was not statistically significant (P = 0.16). Most neonates requiring exchange transfusion were born in tertiary hospitals: 62% for 2001-2006 and 69% for 2007-2012. Among those born in a non-tertiary hospital, the percentage transferred or admitted to a tertiary hospital for exchange transfusion was 63% in 2001-2006 and 77% in 2007-2012. Between 2001 and 2012, there was a decrease in neonatal exchange transfusions in NSW. After the 2007 guideline there was a non-significant increase in the proportion of exchange transfusions performed at tertiary hospitals. Although rare, exchange transfusions are still expected to occur occasionally in non-tertiary hospitals, requiring continuing support for this procedure in these settings. © 2017 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).

  17. Sexual harassment experiences of female graduates of Nigerian tertiary institutions.

    PubMed

    Owoaje, Eme T; Olusola-Taiwo, Omolara

    The sexual harassment experiences of female graduates from tertiary institutions in Nigeria, were explored using self-administered questionnaires. Information was obtained on the respondents' socio-demographic characteristics and experiences of sexual harassment while in their various tertiary institutions. The majority (69.8%) of the respondents had been sexually harassed, with the main perpetrators being male classmates and lecturers. About two-thirds experienced the non-physical type of sexual harassment; 48.2% experienced the physical type. Non-physical harassment included sexual comments (57.8%) and requests to do something sexual in exchange for academic favors (32.2%). Physical forms of sexual harassment included unwanted sexual touching (29.4%) and being intentionally brushed against in a sexual way (28.9%). The effects experienced by victims were depression and perceived insecurity on campus. Sexual harassment is a common occurrence in Nigerian tertiary institutions. Appropriate institutional interventions should be developed to reduce these occurrences.

  18. Three-dimensional tertiary structure of yeast phenylalanine transfer RNA

    NASA Technical Reports Server (NTRS)

    Kim, S. H.; Sussman, J. L.; Suddath, F. L.; Quigley, G. J.; Mcpherson, A.; Wang, A. H. J.; Seeman, N. C.; Rich, A.

    1974-01-01

    Results of an analysis and interpretation of a 3-A electron density map of yeast phenylalanine transfer RNA. Some earlier detailed assignments of nucleotide residues to electron density peaks are found to be in error, even though the overall tracing of the backbone conformation of yeast phenylalanine transfer RNA was generally correct. A new, more comprehensive interpretation is made which makes it possible to define the tertiary interactions in the molecule. The new interpretation makes it possible to visualize a number of tertiary interactions which not only explain the structural role of most of the bases which are constant in transfer RNAs, but also makes it possible to understand in a direct and simple fashion the chemical modification data on transfer RNA. In addition, this pattern of tertiary interactions provides a basis for understanding the general three-dimensional folding of all transfer RNA molecules.

  19. The equity imperative in tertiary education: Promoting fairness and efficiency

    NASA Astrophysics Data System (ADS)

    Salmi, Jamil; Bassett, Roberta Malee

    2014-06-01

    While the share of the tertiary education age cohort (19-25) which is being given the opportunity to study has increased worldwide over the past two decades, this does not in fact translate into reduced inequality. For many young people, especially in the developing world, major obstacles such as disparities in terms of gender, minority population membership or disabilities as well as academic and financial barriers are still standing in their way. The authors of this article propose a conceptual framework to analyse equity issues in tertiary education and document the scope, significance and consequences of disparities in tertiary education opportunities. They throw some light on the main determinants of these inequalities and offer suggestions about effective equity promotion policies directed towards widening participation and improving the chances of success of underprivileged youths in order to create societies which uphold humanistic values.

  20. Spatio-temporal observations of tertiary ozone maximum

    NASA Astrophysics Data System (ADS)

    Sofieva, V. F.; Kyrölä, E.; Verronen, P. T.; Seppälä, A.; Tamminen, J.; Marsh, D. R.; Smith, A. K.; Bertaux, J.-L.; Hauchecorne, A.; Dalaudier, F.; Fussen, D.; Vanhellemont, F.; Fanton D'Andon, O.; Barrot, G.; Guirlet, M.; Fehr, T.; Saavedra, L.

    2009-03-01

    We present spatio-temporal distributions of tertiary ozone maximum (TOM), based on GOMOS (Global Ozone Monitoring by Occultation of Stars) ozone measurements in 2002-2006. The tertiary ozone maximum is typically observed in the high-latitude winter mesosphere at altitude ~72 km. Although the explanation for this phenomenon has been found recently - low concentrations of odd-hydrogen cause the subsequent decrease in odd-oxygen losses - models have had significant deviations from existing observations until recently. Good coverage of polar night regions by GOMOS data has allowed for the first time obtaining spatial and temporal observational distributions of night-time ozone mixing ratio in the mesosphere. The distributions obtained from GOMOS data have specific features, which are variable from year to year. In particular, due to a long lifetime of ozone in polar night conditions, the downward transport of polar air by the meridional circulation is clearly observed in the tertiary ozone maximum time series. Although the maximum tertiary ozone mixing ratio is achieved close to the polar night terminator (as predicted by the theory), TOM can be observed also at very high latitudes, not only in the beginning and at the end, but also in the middle of winter. We have compared the observational spatio-temporal distributions of tertiary ozone maximum with that obtained using WACCM (Whole Atmosphere Community Climate Model) and found that the specific features are reproduced satisfactorily by the model. Since ozone in the mesosphere is very sensitive to HOx concentrations, energetic particle precipitation can significantly modify the shape of the ozone profiles. In particular, GOMOS observations have shown that the tertiary ozone maximum was temporarily destroyed during the January 2005 and December 2006 solar proton events as a result of the HOx enhancement from the increased ionization.

  1. Spatio-temporal observations of the tertiary ozone maximum

    NASA Astrophysics Data System (ADS)

    Sofieva, V. F.; Kyrölä, E.; Verronen, P. T.; Seppälä, A.; Tamminen, J.; Marsh, D. R.; Smith, A. K.; Bertaux, J.-L.; Hauchecorne, A.; Dalaudier, F.; Fussen, D.; Vanhellemont, F.; Fanton D'Andon, O.; Barrot, G.; Guirlet, M.; Fehr, T.; Saavedra, L.

    2009-07-01

    We present spatio-temporal distributions of the tertiary ozone maximum (TOM), based on GOMOS (Global Ozone Monitoring by Occultation of Stars) ozone measurements in 2002-2006. The tertiary ozone maximum is typically observed in the high-latitude winter mesosphere at an altitude of ~72 km. Although the explanation for this phenomenon has been found recently - low concentrations of odd-hydrogen cause the subsequent decrease in odd-oxygen losses - models have had significant deviations from existing observations until recently. Good coverage of polar night regions by GOMOS data has allowed for the first time to obtain spatial and temporal observational distributions of night-time ozone mixing ratio in the mesosphere. The distributions obtained from GOMOS data have specific features, which are variable from year to year. In particular, due to a long lifetime of ozone in polar night conditions, the downward transport of polar air by the meridional circulation is clearly observed in the tertiary ozone maximum time series. Although the maximum tertiary ozone mixing ratio is achieved close to the polar night terminator (as predicted by the theory), TOM can be observed also at very high latitudes, not only in the beginning and at the end, but also in the middle of winter. We have compared the observational spatio-temporal distributions of the tertiary ozone maximum with that obtained using WACCM (Whole Atmosphere Community Climate Model) and found that the specific features are reproduced satisfactorily by the model. Since ozone in the mesosphere is very sensitive to HOx concentrations, energetic particle precipitation can significantly modify the shape of the ozone profiles. In particular, GOMOS observations have shown that the tertiary ozone maximum was temporarily destroyed during the January 2005 and December 2006 solar proton events as a result of the HOx enhancement from the increased ionization.

  2. Discovery of tertiary sulfonamides as potent liver X receptor antagonists.

    PubMed

    Zuercher, William J; Buckholz, Richard G; Campobasso, Nino; Collins, Jon L; Galardi, Cristin M; Gampe, Robert T; Hyatt, Stephen M; Merrihew, Susan L; Moore, John T; Oplinger, Jeffrey A; Reid, Paul R; Spearing, Paul K; Stanley, Thomas B; Stewart, Eugene L; Willson, Timothy M

    2010-04-22

    Tertiary sulfonamides were identified in a HTS as dual liver X receptor (LXR, NR1H2, and NR1H3) ligands, and the binding affinity of the series was increased through iterative analogue synthesis. A ligand-bound cocrystal structure was determined which elucidated key interactions for high binding affinity. Further characterization of the tertiary sulfonamide series led to the identification of high affinity LXR antagonists. GSK2033 (17) is the first potent cell-active LXR antagonist described to date. 17 may be a useful chemical probe to explore the cell biology of this orphan nuclear receptor.

  3. IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (Etbe) ...

    EPA Pesticide Factsheets

    The IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) was released for external peer review in June 2017. EPA’s Science Advisory Board’s (SAB) Chemical Assessment Advisory Committee (CAAC) will conduct a peer review of the scientific basis supporting the ETBE assessment and release a final report of their review. Information regarding the peer review can be found on the SAB website. EPA is conducting an Integrated Risk Information System (IRIS) health assessment for Ethyl Tertiary Butyl Ether (ETBE). The outcome of this project is a Toxicological Review and IRIS Summary for ETBE that will be entered into the IRIS database.

  4. Discovery of Tertiary Sulfonamides as Potent Liver X Receptor Antagonists

    SciT

    Zuercher, William J.; Buckholz†, Richard G.; Campobasso, Nino

    2010-08-12

    Tertiary sulfonamides were identified in a HTS as dual liver X receptor (LXR, NR1H2, and NR1H3) ligands, and the binding affinity of the series was increased through iterative analogue synthesis. A ligand-bound cocrystal structure was determined which elucidated key interactions for high binding affinity. Further characterization of the tertiary sulfonamide series led to the identification of high affinity LXR antagonists. GSK2033 (17) is the first potent cell-active LXR antagonist described to date. 17 may be a useful chemical probe to explore the cell biology of this orphan nuclear receptor.

  5. REVIEW OF CELIAC DISEASE PRESENTATION IN A PEDIATRIC TERTIARY CENTRE.

    PubMed

    Oliveira, Gracinda Nogueira; Mohan, Rajiv; Fagbemi, Andrew

    2018-01-01

    Celiac disease is an immune-mediated disorder with a multiform presentation and therefore a challenging diagnosis. Our purpose is to identify the epidemiological, clinical, laboratory and histologic characteristics of children with celiac disease at diagnosis and on follow-up. Children with previously established or newly diagnosed celiac disease, admitted in a tertiary centre in a two-year period (2014-2016) were recruited. Data was collected retrospectively from electronic medical records and clinical notes, and subsequently analysed with SPSS version 20.0. A total of 159 patients, out of 312, were included. Age ranged from 1 to 17 years (mean ± SD: 8.5±4.5 years, 69% girls). Disease presentation was classical in 60%, non-classical in 25%, subclinical in 10% and 5% classified as potential celiac disease. Non-classical and subclinical profiles had a higher mean age at presentation but not statistically significant (P-value 0.24). The most frequent gastrointestinal features at presentation were abdominal pain (58%), diarrhea (43%) and bloating (27%). A positive family history for celiac disease was present in 24% (n=35). We found anaemia in 23%, low ferritin in 63% and a moderate to severe deficiency of 25-hydroxyvitamin D in 62%. celiac disease -specific serologic testing and esophagogastroduodenoscopy were performed in 99%. Histology revealed modified Marsh 2 or 3 enteropathy in 94%, the remaining had normal histology but positive human leukocyte antigen typing. Clinical improvement at 12 months of gluten-free diet was complete in 51% and partial in 49%. IgA tTG normalized after 12-30 months of gluten-free diet in 45%. On growth assessment at diagnosis and after 12-28 months of gluten-free diet, 100% had height increase (mean ±SD: 7.11±4.43 cm) and 96% weight gain (mean ±SD: 5.60±4.91 kg). Our findings outline the diverse clinical presentations of pediatric celiac disease that should be considered irrespective of age. Increased clinician's awareness will

  6. Double Morphology: Tertiary Syphilis and Acquired Immunodeficiency Syndrome-A Rare Association.

    PubMed

    Ngwanya, R M; Kakande, B; Khumalo, N P

    2017-01-01

    Human immunodeficiency virus (HIV) and Treponema pallidum coinfection is relatively common and accounts for about 25% of primary and secondary syphilis. Tertiary syphilis in HIV-uninfected and HIV-infected patients is vanishingly rare. This is most likely due to early treatment of cases of primary and secondary syphilis. There is rapid progression to tertiary syphilis in HIV-infected patients. A 49-year-old woman diagnosed with HIV Type 1 infection and cluster of differentiation 4 (CD4) count of 482 presented with a four-week history of multiple crusted plaques, nodules, and ulcers on her face, arms, and abdomen. Her past history revealed red painful eyes six months prior to this presentation. She had generalized lymphadenopathy, no alopecia, and no palmar-plantar or mucosal lesions. There were no features suggestive of secondary syphilis. Neurological examination was normal. Her rapid plasma reagin test was positive to a titer of 64. She was treated with Penicillin G 20 mu IVI daily for 2 weeks. Penicillin remains the treatment of choice in syphilitic infected HIV negative and HIV-infected individuals. In neurosyphilis, the dose of Penicillin GIVI is 18-24 mu daily for 10-14 days. This case report demonstrates the importance of excluding syphilis in any HIV-infected patient.

  7. Geologic and geomorphic controls of coal development in some Tertiary Rocky Mountain basins, USA

    Flores, R.M.

    1993-01-01

    Previous investigations have not well defined the controls on the development of minable coals in fluvial environments. This study was undertaken to provide a clearer understanding of these controls, particularly in of the lower Tertiary coal-bearing deposits of the Raton and Powder River basins in the Rocky Mountain region of the United States. In this region, large amounts of coals accumulated in swamps formed in the flow-through fluvial systems that infilled these intermontane basins. Extrabasinal and intrabasinal tectonism partly controlled the stratigraphic and facies distributions of minable coal deposits. The regional accumulation of coals was favored by the rapid basin subsidence coupled with minimal uplift of the source area. During these events, coals developed in swamps associated with anastomosed and meandering fluvial systems and alluvial fans. The extensive and high rate of sediment input from these fluvial systems promoted the formation of ombrotrophic, raised swamps, which produced low ash and anomalously thick coals. The petrology and palynology of these coals, and the paleobotany of the associated sediments, suggest that ombrotrophic, raised swamps were common in the Powder River Basin, where the climate during the early Tertiary was paratropical. The paleoecology of these swamps is identical to that of the modern ombrotrophic, raised swamps of the Baram and Mahakam Rivers of Borneo. ?? 1993.

  8. Challenges and opportunities for primary, secondary, and tertiary prevention of Chagas' disease.

    PubMed

    Rassi, A; Dias, J C P; Marin-Neto, J A; Rassi, A

    2009-04-01

    A century after its discovery, Chagas' disease still represents a major public health challenge in Latin America. Moreover, because of growing population movements, an increasing number of cases of imported Chagas' disease have now been detected in non-endemic areas, such as North America and some European countries. This parasitic zoonosis, caused by Trypanosoma cruzi, is transmitted to humans by infected Triatominae insects, or occasionally by non-vectorial mechanisms, such as blood transfusion, mother to fetus, or oral ingestion of materials contaminated with parasites. Following the acute phase of the infection, untreated individuals enter a chronic phase that is initially asymptomatic or clinically unapparent. Usually, a few decades later, 40-50% of patients develop progressive cardiomyopathy and/or motility disturbances of the oesophagus and colon. In the last decades several interventions targeting primary, secondary and tertiary prevention of Chagas' disease have been attempted. While control of both vectorial and blood transfusion transmission of T cruzi (primary prevention) has been successful in many regions of Latin America, early detection and aetiological treatment of asymptomatic subjects with Chagas' disease (secondary prevention) have been largely underutilised. At the same time, in patients with established chronic disease, several pharmacological and non-pharmacological interventions are currently available and have been increasingly used with the intention of preventing or delaying complications of the disease (tertiary prevention). In this review we discuss in detail each of these issues.

  9. Two new carnivores from an unusual late Tertiary forest biota in eastern North America.

    PubMed

    Wallace, Steven C; Wang, Xiaoming

    2004-09-30

    Late Cenozoic terrestrial fossil records of North America are biased by a predominance of mid-latitude deposits, mostly in the western half of the continent. Consequently, the biological history of eastern North America, including the eastern deciduous forest, remains largely hidden. Unfortunately, vertebrate fossil sites from this vast region are rare, and few pertain to the critically important late Tertiary period, during which intensified global climatic changes took place. Moreover, strong phylogenetic affinities between the flora of eastern North America and eastern Asia clearly demonstrate formerly contiguous connections, but disparity among shared genera (eastern Asia-eastern North America disjunction) implies significant periods of separation since at least the Miocene epoch. Lacustrine sediments deposited within a former sinkhole in the southern Appalachian Mountains provide a rare example of a late Miocene to early Pliocene terrestrial biota from a forested ecosystem. Here we show that the vertebrate remains contained within this deposit represent a unique combination of North American and Eurasian taxa. A new genus and species of the red (lesser) panda (Pristinailurus bristoli), the earliest and most primitive so far known, was recovered. Also among the fauna are a new species of Eurasian badger (Arctomeles dimolodontus) and the largest concentration of fossil tapirs ever recorded. Cladistical analyses of the two new carnivores strongly suggest immigration events that were earlier than and distinct from previous records, and that the close faunal affinities between eastern North America and eastern Asia in the late Tertiary period are consistent with the contemporaneous botanical record.

  10. Mantle source volumes and the origin of the mid-Tertiary ignimbrite flare-up in the southern Rocky Mountains, western U.S.

    NASA Astrophysics Data System (ADS)

    Farmer, G. Lang; Bailley, Treasure; Elkins-Tanton, Linda T.

    2008-04-01

    Voluminous intermediate to silicic composition volcanic rocks were generated throughout the southern Rocky Mountains, western U.S., during the mid-Tertiary "ignimbrite flare-up", principally at the San Juan and Mogollon-Datil volcanic fields. At both volcanic centers, radiogenic isotope data have been interpreted as evidence that 50% or more of the volcanic rocks (by mass) were derived from mantle-derived, mafic parental magmas, but no consensus exists as to whether melting was largely of lithospheric or sub-lithospheric mantle. Recent xenolith studies, however, have revealed that thick (> 100 km), fertile, and hydrated continental lithosphere was present beneath at least portions of the southern Rocky Mountains during the mid-Tertiary. The presence of such thick mantle lithosphere, combined with an apparent lack of syn-magmatic extension, leaves conductive heating of lithospheric mantle as a plausible method of generating the mafic magmas that fueled the ignimbrite flare-up in this inland region. To further assess this possibility, we estimated the minimum volume of mantle needed to generate the mafic magmas parental to the preserved mid-Tertiary igneous rocks. Conservative estimates of the mantle source volumes that supplied the Mogollon-Datil and San Juan volcanic fields are ˜ 2 M km 3 and ˜ 7 M km 3, respectively. These volumes could have comprised only lithospheric mantle if at least the lower ˜ 20 km of the mantle lithosphere beneath the entire southern Rocky Mountains region underwent partial melting during the mid-Tertiary and if the resulting mafic magmas were drawn laterally for distances of up to ˜ 300 km into each center. Such widespread melting of lithospheric mantle requires that the lithospheric mantle have been uniformly fertile and primed for melting in the mid-Tertiary, a possibility if the lithospheric mantle had experienced widespread hydration and refrigeration during early Tertiary low angle subduction. Exposure of the mantle lithosphere

  11. Self-Assessment in Professional Programmes within Tertiary Institutions

    ERIC Educational Resources Information Center

    Bourke, Roseanna

    2014-01-01

    Self-assessment at tertiary level is a critical pedagogical and assessment tool to support students in their transition to professional careers where on-going learning and assessment is required. Beyond the safety-net of course content, external assessment and pre-determined criteria, novice professionals need to find ways to self-assess their…

  12. Tertiary syphilis in the lumbar spine: a case report.

    PubMed

    Bai, Yang; Niu, Feng; Liu, Lidi; Sha, Hui; Wang, Yimei; Zhao, Song

    2017-07-24

    The incidence of tertiary syphilis involvement in the spinal column with destructive bone lesions is very rare. It is difficult to establish the correct diagnosis from radiographs and histological examination alone. Limited data are available on surgical treatment to tertiary syphilitic spinal lesions. In this article, we report a case of tertiary syphilis in the lumbar spine with osteolytic lesions causing cauda equina compression. A 44-year-old man who suffered with low back pain for 6 months and progressive radiating pain at lower extremity for 1 week. Radiologic findings showed osteolytic lesion and new bone formation in the parts of the bodies of L4 and L5. Serum treponema pallidum hemagglutination (TPHA) test was positive. A surgery of posterior debridement, interbody and posterolateral allograft bone fusion with instrumentation from L3 to S1 was performed. The low back pain and numbness abated after operation. But the follow-up radiographs showed absorption of the bone grafts and failure of instrumentation. A Charcot's arthropathy was formed between L4 and L5. It is challenging to diagnose the tertiary syphilis in the spine. Surgery is a reasonable auxiliary method to antibiotic therapy for patients who suffered with neuropathy. Charcot's arthropathy should be considered as an operative complication.

  13. A Conceptual Approach for Blended Leadership for Tertiary Education Institutions

    ERIC Educational Resources Information Center

    Jones, Sandra; Harvey, Marina; Lefoe, Geraldine

    2014-01-01

    Over the last 20 years, the tertiary education sector has adopted new administrative management approaches, with the aim of improving accountable and strategic focus. Over the same period, the question of how to build leadership capacity to improve learning and teaching and research outcomes has led to discussion on what constitutes academic…

  14. Tertiary climatic change in the marginal northeastern Pacific Ocean

    Addicott, W.O.

    1969-01-01

    Analysis of distributional patterns of shallow-water molluscan faunas of the middle latitudes of the marginal northeastern Pacific Ocean discloses a sharp reversal during the Miocene of the progressive climatic deterioration. A low point in the Tertiary cooling trend during the Oligocene was followed by climatic warming that culminated during the middle Miocene, as illustrated by a series of zoogeographic profiles.

  15. Tertiary climatic change in the marginal northeastern pacific ocean.

    PubMed

    Addicott, W O

    1969-08-08

    Analysis of distributional patterns of shallow-water molluscan faunas of the middle latitudes of the marginal northeastern Pacific Ocean discloses a sharp reversal during the Miocene of the progressive climatic deterioration. A low point in the Tertiary cooling trend during the Oligocene was followed by climatic warming that culminated during the middle Miocene, as illustrated by a series of zoogeographic profiles.

  16. An Examination of Tertiary Students' Desire to Found an Enterprise

    ERIC Educational Resources Information Center

    Birdthistle, Naomi

    2008-01-01

    Purpose: The purpose of this paper is twofold. First, the paper aims to identify and explain the behaviour and intentions of students in their decision to start entrepreneurial activities and establish an enterprise. Second, the paper aims to identify whether students in tertiary level institutions in Ireland display the personality traits of an…

  17. Food Insecurity: Is It an Issue among Tertiary Students?

    ERIC Educational Resources Information Center

    Gallegos, Danielle; Ramsey, Rebecca; Ong, Kai Wen

    2014-01-01

    Insufficient access to food is known to compromise tertiary studies. Students often belong to groups known to have poor food security such as those renting or relying on government payments. The present study administered a cross-sectional survey incorporating the USDA food security survey module (FSSM) to 810 students at a metropolitan university…

  18. Pedagogical Practices of Reflection in Tertiary Dance Education

    ERIC Educational Resources Information Center

    Leijen, Ali; Lam, Ineke; Simons, P. Robert-Jan; Wildschut, Liesbeth

    2008-01-01

    The three different perspectives on reflection in education are embedded in the philosophical traditions of pragmatism, critical social theory and Kant. We aimed to describe the pedagogical practices of reflection, and to develop a descriptive model of the practices of reflection in tertiary dance education which can be used by dance educators to…

  19. The Managerial Approach to Tertiary Education: A Critical Analysis.

    ERIC Educational Resources Information Center

    Baron, Bernard

    The various elements of the management approach to tertiary education (broadly, all institutions of further and higher education maintained by local authorities) are identified, with the principal focus on the general approach known as "Management by Objectives" (MBO). The arguments for and against its use and possible hazards following…

  20. Assessing Manual and Online Course Registration in Nigeria Tertiary Institutions

    ERIC Educational Resources Information Center

    Oladunjoye, Patrick; Omemu, Felix

    2013-01-01

    The study is aimed at assessing the perceptions of male and female students on manual and online course registration systems in tertiary institutions in Nigeria. One research question was formulated to guide the study. A questionnaire containing 20 items on assessing the perceptions of students on manual and online course registration was drawn.…

  1. Epilepsy in Ireland: towards the primary-tertiary care continuum.

    PubMed

    Varley, Jarlath; Delanty, Norman; Normand, Charles; Coyne, Imelda; McQuaid, Louise; Collins, Claire; Boland, Michael; Grimson, Jane; Fitzsimons, Mary

    2010-01-01

    Epilepsy is a chronic neurological disease affecting people of every age, gender, race and socio-economic background. The diagnosis and optimal management relies on contribution from a number of healthcare disciplines in a variety of healthcare settings. To explore the interface between primary care and specialist epilepsy services in Ireland. Using appreciative inquiry, focus groups were held with healthcare professionals (n=33) from both primary and tertiary epilepsy specialist services in Ireland. There are significant challenges to delivering a consistent high standard of epilepsy care in Ireland. The barriers that were identified are: the stigma of epilepsy, unequal access to care services, insufficient human resources, unclear communication between primary-tertiary services and lack of knowledge. Improving the management of people with epilepsy requires reconfiguration of the primary-tertiary interface and establishing clearly defined roles and formalised clinical pathways. Such initiatives require resources in the form of further education and training and increased usage of information communication technology (ICT). Epilepsy services across the primary-tertiary interface can be significantly enhanced through the implementation of a shared model of care underpinned by an electronic patient record (EPR) system and information communication technology (ICT). Better chronic disease management has the potential to halt the progression of epilepsy with ensuing benefits for patients and the healthcare system. Copyright 2009 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

  2. Reform and Development of Tertiary Education in Europe. Recommendations.

    ERIC Educational Resources Information Center

    de Moor, R. A.; Vedel, Doyer Georges

    Tertiary education policies in seven Western European and seven Southern European countries are evaluated in two reports. In the first report by R. A. de Moor, attention is focused on France, the Federal Republic of Germany, the Netherlands, Norway, Sweden, Switzerland, and the United Kingdom. The evaluation and policy recommendations for the…

  3. Secret Cults in Tertiary Institutions in Nigeria: An Appraisal

    ERIC Educational Resources Information Center

    Aluede, Raymond O. A.; Oniyama, Hope O.

    2009-01-01

    Cultism has remained a problem for tertiary institutions in Nigeria and the Larger Nigerian society since the first decade of the existence of university education in Nigeria. It has been worrisome to have children on campuses and several measures had been adopted to curb cultism some of such measures were the expulsion of the cultists caught and…

  4. Hong Kong Tertiary Students' Conceptions of Assessment of Academic Ability

    ERIC Educational Resources Information Center

    Wang, Zhenlin; Brown, Gavin T. L.

    2014-01-01

    Students' beliefs, attitudes, experiences and responses towards assessment reflect the ecology of their specific context. The study examines Hong Kong tertiary students' conceptions of assessment using focus group interviews and the content analysis technique. Using six focus groups, 26 Hong Kong university students were interviewed. Hong Kong…

  5. The Equity Imperative in Tertiary Education: Promoting Fairness and Efficiency

    ERIC Educational Resources Information Center

    Salmi, Jamil; Bassett, Roberta Malee

    2014-01-01

    While the share of the tertiary education age cohort (19-25) which is being given the opportunity to study has increased worldwide over the past two decades, this does not in fact translate into reduced inequality. For many young people, especially in the developing world, major obstacles such as disparities in terms of gender, minority population…

  6. Endosymbiotic gene transfer in tertiary plastid-containing dinoflagellates.

    PubMed

    Burki, Fabien; Imanian, Behzad; Hehenberger, Elisabeth; Hirakawa, Yoshihisa; Maruyama, Shinichiro; Keeling, Patrick J

    2014-02-01

    Plastid establishment involves the transfer of endosymbiotic genes to the host nucleus, a process known as endosymbiotic gene transfer (EGT). Large amounts of EGT have been shown in several photosynthetic lineages but also in present-day plastid-lacking organisms, supporting the notion that endosymbiotic genes leave a substantial genetic footprint in the host nucleus. Yet the extent of this genetic relocation remains debated, largely because the long period that has passed since most plastids originated has erased many of the clues to how this process unfolded. Among the dinoflagellates, however, the ancestral peridinin-containing plastid has been replaced by tertiary plastids on several more recent occasions, giving us a less ancient window to examine plastid origins. In this study, we evaluated the endosymbiotic contribution to the host genome in two dinoflagellate lineages with tertiary plastids. We generated the first nuclear transcriptome data sets for the "dinotoms," which harbor diatom-derived plastids, and analyzed these data in combination with the available transcriptomes for kareniaceans, which harbor haptophyte-derived plastids. We found low level of detectable EGT in both dinoflagellate lineages, with only 9 genes and 90 genes of possible tertiary endosymbiotic origin in dinotoms and kareniaceans, respectively, suggesting that tertiary endosymbioses did not heavily impact the host dinoflagellate genomes.

  7. The Place of VET in the Tertiary Sector. Conference Paper

    ERIC Educational Resources Information Center

    Beddie, Francesca

    2010-01-01

    The utilitarian spirit of Australian education has meant that since the nineteenth century the notion of tertiary education has embraced all post-school learning, delivered in sandstone universities or working men's institutes or on the job. This is not the definition the peak bodies TAFE (Technical and Further Education) Directors Australia (TDA)…

  8. Microstructural Characterization of Alloy 617 Crept into the Tertiary Regime

    SciT

    Lillo, Thomas Martin; Wright, Richard Neil

    2015-07-01

    The microstructure of Alloy 617 was characterized following creep tests interrupted at total creep strains ranging from 2-20%. A range of creep temperatures (750-1000oC) and initial creep stresses (10-145 MPa) produced creep test durations ranging from 1 to 5800 hours. Image analysis of optical photomicrographs on longitudinal sections of the gage length was used to document the fraction of creep porosity as a function of creep parameters. Creep porosity was negligible below tertiary creep strains of 10% and increased with tertiary creep strain, thereafter. For a given temperature and total creep strain, creep porosity increased with decreasing creep stress. Creepmore » porosity increased linearly with duration of the creep experiment. TEM performed on the gage sections did not reveal significant creep cavity formation on grain boundaries at the sub-micron level. It was concluded that the onset of tertiary creep did not result from creep cavitation and more likely arose due to the formation of low energy dislocation substructures with increasing tertiary strain.« less

  9. Learning to teach mathematical modelling in secondary and tertiary education

    NASA Astrophysics Data System (ADS)

    Ferri, Rita Borromeo

    2017-07-01

    Since 2003 mathematical modelling in Germany is not only a topic for scientific disciplines in university mathematics courses, but also in school starting with primary school. This paper shows what mathematical modelling means in school and how it can be taught as a basis for complex modeling problems in tertiary education.

  10. Adults Studying Pure Mathematics in Adult Tertiary Preparation.

    ERIC Educational Resources Information Center

    Bennison, Anne

    2002-01-01

    Investigated the experiences of a group of adults enrolled in the Pure Mathematics module of the Certificate IV in Adult Tertiary Preparation in 2000 at one of the Institutes of TAFE in Brisbane, Australia. Classroom learning experiences, exposure to technology, and the impact of returning to study on other facets of students' lives were…

  11. Automated extraction and classification of RNA tertiary structure cyclic motifs

    PubMed Central

    Lemieux, Sébastien; Major, François

    2006-01-01

    A minimum cycle basis of the tertiary structure of a large ribosomal subunit (LSU) X-ray crystal structure was analyzed. Most cycles are small, as they are composed of 3- to 5 nt, and repeated across the LSU tertiary structure. We used hierarchical clustering to quantify and classify the 4 nt cycles. One class is defined by the GNRA tetraloop motif. The inspection of the GNRA class revealed peculiar instances in sequence. First is the presence of UA, CA, UC and CC base pairs that substitute the usual sheared GA base pair. Second is the revelation of GNR(Xn)A tetraloops, where Xn is bulged out of the classical GNRA structure, and of GN/RA formed by the two strands of interior-loops. We were able to unambiguously characterize the cycle classes using base stacking and base pairing annotations. The cycles identified correspond to small and cyclic motifs that compose most of the LSU RNA tertiary structure and contribute to its thermodynamic stability. Consequently, the RNA minimum cycles could well be used as the basic elements of RNA tertiary structure prediction methods. PMID:16679452

  12. Effectiveness of Using Games in Tertiary-Level Mathematics Classrooms

    ERIC Educational Resources Information Center

    Afari, Ernest; Aldridge, Jill M.; Fraser, Barry J.

    2012-01-01

    The primary focus of this study was to investigate the effectiveness of games when used in tertiary-level mathematics classes in the United Arab Emirates. Our study incorporated a mixed-method approach that involved surveys (to assess students' perceptions of the learning environment and attitudes towards mathematics), interviews, observations of…

  13. Secondary and tertiary isoquinoline alkaloids from Xylopia parviflora.

    PubMed

    Nishiyama, Yumi; Moriyasu, Masataka; Ichimaru, Momoyo; Iwasa, Kinuko; Kato, Atsushi; Mathenge, Simon G; Chalo Mutiso, Patrick B; Juma, Francis D

    2006-12-01

    From the secondary and tertiary alkaloidal fractions of the root and the bark of Xylopia parviflora (Annonaceae), the isoquinoline alkaloids, 10,11-dihydroxy-1,2-dimethoxynoraporphine and parvinine were isolated, along with 39 known alkaloids. Their structures were determined on the basis of analysis of spectroscopic data.

  14. Learning Assessment in Tertiary Business Education with Revised Taxonomy

    ERIC Educational Resources Information Center

    Hossain, Md. Shajjad

    2017-01-01

    The goal of this study was to evaluate the assessment criteria of learning in tertiary education of Bangladesh. The study was aimed at identifying percentage of questions during learning assessment of business graduates following cognitive levels of Bloom's in revised Taxonomy and to test whether there was any significant difference in the…

  15. The Impact of Cooperative Learning on Tertiary EFL Learners' Motivation

    ERIC Educational Resources Information Center

    Ning, Huiping; Hornby, Garry

    2014-01-01

    This study was aimed at investigating the impact of cooperative learning on the motivation of tertiary English learners. Participants were from two randomly assigned classes at a university in the north of China. A pre-test-post-test control group design was employed to compare the impact of the cooperative learning approach with that of…

  16. Students' Experience of the Transition from School to Tertiary College.

    ERIC Educational Resources Information Center

    Prout, Gillian A.

    1993-01-01

    Investigates the experiences of a group of students as they transferred from school to tertiary college at age 16. Highlights the distinction drawn between the curriculum-related aspects and the personal/social aspects of the students' concerns. Discusses implications of the findings in the context of a recent HMI Report on the pastoral curriculum…

  17. Counselling for Sustainable Peace in Tertiary Institutions in Nigeria

    ERIC Educational Resources Information Center

    Nduka-Ozo, Stella Ngozi

    2016-01-01

    This study reviewed the nature of peace in Tertiary Institutions in Nigeria using Ebonyi State University as a case study. The purpose of the study was to review the various factors responsible for lack of peace. The sample was drawn from the three hundred level students of the Faculty of Education. Thirty students were selected from each of the…

  18. High School Graduates' Readiness for Tertiary Education in Saudi Arabia

    ERIC Educational Resources Information Center

    Khoshaim, Heba Bakr

    2017-01-01

    There has been a huge improvement in the education system in Saudi Arabia quantitatively and qualitatively. Nevertheless, many researchers indicated that high school graduates are not ready for higher education. Especially when considering mathematical compensations, high-demanded skills for tertiary academic programs, Saudi students have been…

  19. Predictors of Attrition and Achievement in a Tertiary Bridging Program

    ERIC Educational Resources Information Center

    Whannell, Robert

    2013-01-01

    This study examines the attrition and achievement of a sample of 295 students in an on-campus tertiary bridging program at a regional university. A logistic regression analysis using enrolment status, age and the number of absences from scheduled classes at week three of the semester as predictor variables correctly predicted 92.8 percent of…

  20. Accountability of Tertiary Education at the National Level: A Chimera?

    ERIC Educational Resources Information Center

    Lindsay, Alan; O'Byrne, Garry

    1979-01-01

    The concept of accountability and its application to Australian higher education are discussed. It is suggested that due to political, financial, and educational characteristics of tertiary education at the national system level there are fundamental and insoluble problems associated with achieving accountability. (SF)

  1. PASS Student Leader and Mentor Roles: A Tertiary Leadership Pathway

    ERIC Educational Resources Information Center

    Skalicky, Jane; Caney, Annaliese

    2010-01-01

    In relation to developing leadership skills during tertiary studies, this paper considers the leadership pathway afforded by a Peer Assisted Study Sessions (PASS) program which includes the traditional PASS Leader role and a more senior PASS Mentor role. Data was collected using a structured survey with open-ended questions designed to capture the…

  2. Introductory Statistics Course Tertiary Students' Understanding of P-Values

    ERIC Educational Resources Information Center

    Reaburn, Robyn

    2014-01-01

    This study aimed to gain knowledge of students' beliefs and difficulties in understanding p-values, and to use this knowledge to develop improved teaching programs. This study took place over four consecutive teaching semesters of a one-semester tertiary statistics unit. The study was cyclical, in that the results of each semester were used to…

  3. Tertiary Educational Institutions for Teaching, Research and Development

    ERIC Educational Resources Information Center

    Amoo, Sikiru A.

    2014-01-01

    This paper examines the quality of teaching and research in developing human resources to facilitate the development of tertiary education in the nation. It discusses the challenges and the roles of research in higher education. The author argues that the combination of content and pedagogical knowledge could help to develop human resources for…

  4. Deterministic Demographic Characteristics in Tertiary Education: An Exploratory Study

    ERIC Educational Resources Information Center

    Morton, Lisa; Lamb, Charles

    2006-01-01

    This paper reports the responses of 235 tertiary commerce students to a questionnaire in relation to their learning and assessment experiences. Significant correlations between measures were used to identify underlying constructs within the overall set of variable measures. Logistic regression incorporating the factors was then used to further…

  5. Tertiary Institutions, Entrepreneurship Education and Youth Empowerment in Nigeria

    ERIC Educational Resources Information Center

    Olasunkanmi, Abari Ayodeji; Olufunke, Oyetola Idowu; Adetayo, Okunuga Adedapo

    2013-01-01

    Entrepreneurship Education has recently become a global phenomenon in the development of world youths for self employment and self-reliance. The Nigerian nation cannot afford to be left out and left behind in this new trend in education both at the secondary and tertiary levels. However, while the Universal Basic Education (UBE) curriculum has…

  6. 21 CFR 522.1885 - Prednisolone tertiary butylacetate suspension.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Prednisolone tertiary butylacetate suspension. 522.1885 Section 522.1885 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS IMPLANTATION OR INJECTABLE DOSAGE FORM NEW...

  7. The Pipe Creek Sinkhole biota, a diverse late tertiary continental fossil assemblage from Grant County, Indiana

    Farlow, J.O.; Sunderman, J.A.; Havens, J.J.; Swinehart, A.L.; Holman, J.A.; Richards, R.L.; Miller, N.G.; Martin, R.A.; Hunt, R.M.; Storrs, G.W.; Curry, B. Brandon; Fluegeman, R.H.; Dawson, M.; Flint, M.E.T.

    2001-01-01

    Quarrying in east-central Indiana has uncovered richly fossiliferous unconsolidated sediment buried beneath Pleistocene glacial till. The fossiliferous layer is part of a sedimentary deposit that accumulated in a sinkhole developed in the limestone flank beds of a Paleozoic reef. Plant and animal (mostly vertebrate) remains are abundant in the fossil assemblage. Plants are represented by a diversity of terrestrial and wetland forms, all of extant species. The vertebrate assemblage (here designated the Pipe Creek Sinkhole local fauna) is dominated by frogs and pond turtles, but fishes, birds; snakes and small and large mammals are also present; both extinct and extant taxa are represented. The mammalian assemblage indicates an early Pliocene age (latest Hemphillian or earliest Blancan North American Land Mammal Age). This is the first Tertiary continental biota discovered in the interior of the eastern half of North America.

  8. Transmembrane Segments Form Tertiary Hairpins in the Folding Vestibule of the Ribosome.

    PubMed Central

    Tu, LiWei; Khanna, Pooja; Deutsch, Carol

    2013-01-01

    Folding of membrane proteins begins in the ribosome as the peptide is elongated. During this process, the nascent peptide navigates along 100 Å of tunnel from the peptidyltransferase center to the exit port. Proximal to the exit port is a ‘folding vestibule’ that permits the nascent peptide to compact and explore conformational space for potential tertiary folding partners. The latter occurs for cytosolic subdomains, but has not yet been shown for transmembrane segments. We now demonstrate, using an accessibility assay and an improved, intramolecular crosslinking assay, that the helical transmembrane S3b-S4 hairpin (‘paddle’) of a voltage-gated potassium (Kv) channel, a critical region of the Kv voltage sensor, forms in the vestibule. S3-S4 hairpin interactions are detected at an early stage of Kv biogenesis. Moreover, this vestibule hairpin is consistent with a closed-state conformation of the Kv channel in the plasma membrane. PMID:24055377

  9. Offset of Tertiary arcs on the Alaska Peninsula: A section in Geological Survey research, fiscal year 1981

    ,

    1984-01-01

    Geologic mapping and potassium-argon dating by R. L. Detterman, F. H. Wilson, J. E. Case, and Nora Shew in the Ugashik and western part of the Karluk quadrangles have shown that the Eocene and Oligocene volcanic arc continues into these quadrangles from the south in the Chignik and Sutwik Island quadrangles. Surface exposures of the arc extend northward to approximately 57°30'N., or midway through the Ugashik quadrangle, but none are observed north of that point. Subsurface drill-hole data (Brockway and others, 1975) indicate continuation of the arc, possibly offset to the northwest of the northernmost known surface exposures.In the extreme northern part of the Ugashik and Karluk quadrangles, volcanic rocks again become important. These volcanic rocks are as yet undated; however, they may be related to the Katmai late Tertiary volcanic centers.Like the early Tertiary volcanic arc, the present-day Aleutian arc is also offset to the northwest in the northern part of the Ugashik and Karluk quadrangles. No major offset of the Mesozoic rocks is indicated through the offset zone; this fact suggests a change in the Tertiary tectonic regime in the area of the offset.

  10. Basin analysis of tertiary strata in the Pattani Basin, Gulf of Thailand

    SciT

    Chonchawalit, A.; Bustin, R.M.

    The stratigraphic and structural evolution of the Pattani basin, the most prolific petroleum basin in Thailand, reflects the extensional tectonics of continental southeast Asia. East-west extension, a product of the northward collision of India with Eurasia since the early Tertiary resulted in the formation of a series of north-south-trending sedimentary basins including the Pattani basin. Subsidence and thermal histories of the basin can generally be accounted for by nonuniform lithospheric stretching. The validity of nonuniform lithospheric stretching as a mechanic for the formation of the Pattani basin is confirmed by a reasonably good agreement between modeled and observed vitrinite reflectancemore » at various depths and locations. The amount of stretching and surface heat flow generally increases from the basin margin to the basin center. Crustal stretching factor ([beta]) ranges from 1.3 at the basin margin to 2.8 in the center. Subcrustal stretching factor ([sigma]) ranges from 1.3 at the margin to more than 3.0 in the center. The stretching of the lithosphere may have extended basement rocks as much as 45 to 90 km and may have caused the upwelling of asthenosphere, resulting in high heat flow. The sedimentary succession in the Pattani basin is divisible into synrift and postrift sequences. The synrift sequences comprise (1) late Eocene ( ) to early Oligocene alluvial fan, braided river, and flood-plain deposits; (2) late Oligocene to early Miocene floodplain and channel deposits; and (3) an early Miocene regressive package of marine to nonmarine sediments. Deposition of synrift sequences corresponded to rifting and extension, which included episodic block faulting and rapid subsidence. Postrift succession comprises (1) an early to middle Miocene regressive package of shallow marine to nonmarine sediments, (2) a late early Miocene transgressive package; and (3) a late Miocene to Pleistocene transgression succession.« less

  11. Early Prevention of Childhood Disability in Developing Countries.

    ERIC Educational Resources Information Center

    Simeonsson, Rune J.

    1991-01-01

    This paper presents a disability prevention framework for community-based rehabilitation services, by conceptualizing early intervention in terms of primary, secondary, and tertiary levels of prevention. The framework views prevention as the effort to reduce a disability's expression, duration, or extended impact. (Author/JDD)

  12. A Comparison of Career Success between Graduates of Vocational and Academic Tertiary Education

    ERIC Educational Resources Information Center

    Backes-Gellner, Uschi; Geel, Regula

    2014-01-01

    This paper analyses whether tertiary education of different types, i.e., academic or vocational tertiary education, leads to more or less favorable labor market outcomes. We study the problem for Switzerland, where more than two thirds of the workforce gain vocational secondary degrees and a substantial number go on to a vocational tertiary degree…

  13. The Policy Determinants of Investment in Tertiary Education. OECD Economics Department Working Papers, No. 576

    ERIC Educational Resources Information Center

    Martins, Joaquim Oliveira; Boarini, Romina; Strauss, Hubert; de la Maisonneuve, Christine; Saadi, Clarice

    2007-01-01

    This paper assesses how policies and institutions affect private returns to invest in tertiary human capital, the ability of individuals to finance this investment and the institutional characteristics of tertiary education systems. Focusing on core tertiary education services, the paper presents new measures of private returns to tertiary…

  14. Analysis of Management Practices in Lagos State Tertiary Institutions through Total Quality Management Structural Framework

    ERIC Educational Resources Information Center

    AbdulAzeez, Abbas Tunde

    2016-01-01

    This research investigated total quality management practices and quality teacher education in public tertiary institutions in Lagos State. The study was therefore designed to analyse management practices in Lagos state tertiary institutions through total quality management structural framework. The selected public tertiary institutions in Lagos…

  15. Policy Innovation and Tertiary Education Graduation Rates: A Cross-Country Analysis

    ERIC Educational Resources Information Center

    Delaney, Jennifer A.; Yu, Patricia

    2013-01-01

    This study extends Trow's theory of higher education development to examine changes in national-level tertiary education graduation rates. Applying Trow's framework we arrive at three stages: (1) elite systems with gross tertiary graduation rates less than 15%, (2) massified systems with gross tertiary graduation rates between 15% and 50%, and (3)…

  16. A New Synthesis of Tertiary Alkyl N-Arylcarbamates from Isocyanates.

    ERIC Educational Resources Information Center

    Bailey, William J.; Griffith, James R.

    1978-01-01

    The method involves the dissolution of a small piece of metallic lithium in a small quantity of tertiary alcohol followed by addition to a mixture of the isocyanate and the tertiary alcohol in ether. This should be useful in organic chemistry laboratory courses for the identification of tertiary alcohols. (Author/BB)

  17. Discovering Tertiary Education through Others' Eyes and Words: Exploring Submissions to New Zealand's Review of Its Tertiary Education Sector

    ERIC Educational Resources Information Center

    Shephard, Kerry

    2017-01-01

    A general inductive analysis was applied to 98 submissions made to a recent review of New Zealand's tertiary education system, primarily to enable those interested to engage with multiple viewpoints about this highly complex educational system. The analysis yielded three substantial themes that reoccur throughout the submissions and that may…

  18. Tertiary and Quaternary Research with Remote Sensing Methods

    NASA Technical Reports Server (NTRS)

    Conel, J. E.

    1985-01-01

    Problems encountered in mapping the Quaternary section of the Wind River Region using remote sensing methods are discussed. Analysis of the stratigraphic section is a fundamental aspect of the geologic study of sedimentary basins. Stratigraphic analysis of post-Cretaceous rocks in the Wind River Basin encounters problems of a distinctly different character from those involved in studying the pre-Cretaceous section. The interior of the basin is predominantly covered by Tertiary and Quaternary sediments. These rocks, except on the basin margin to the north, are mostly flat lying or gently dipping. The Tertiary section consists of sandstones, siltstones, and tuffaceous sediments, some variegated, but in general poorly bedded and of great lithologic similarity. The Quaternary sediments consist of terrace, fan, and debris tongue deposits, unconsolidated alluvium occupying the bottoms of modern watercourses, deposits of eolian origin and tufa. Terrace and fan deposits are compositionally diverse and reflect the lithologic diversity of the source terranes.

  19. Global fire at the Cretaceous-Tertiary boundary

    NASA Technical Reports Server (NTRS)

    Wolbach, Wendy S.; Gilmour, Iain; Anders, Edward; Orth, Charles J.; Brooks, Robert R.

    1988-01-01

    Cretaceous-Tertiary boundary clays rich in iridium from five sites in Europe and New Zealand were investigated. The clays are found to be 100-10,000-fold-enriched in elemental carbon (mainly soot), which is isotopically uniform and apparently comes from a single global fire. The soot layer coincides with the iridium layer, suggesting that the fire was triggered by meteorite impact and began before the ejecta had settled.

  20. Major wildfires at the Cretaceous-Tertiary boundary

    NASA Technical Reports Server (NTRS)

    Anders, Edward; Wolbach, Wendy S.; Gilmour, Iain

    1991-01-01

    The current status of the reconstruction of major biomass fire events at the Cretaceous-Tertiary boundary is discussed. Attention is given to the sources of charcoal and soot, the identification of biomass and fossil carbon, and such ignition-related problems as delated fires, high atmospheric O2 content, ignition mechanisms, and the greenhouse-effect consequences of fire on the scale envisioned. Consequences of these factors for species extinction patterns are noted.

  1. Tertiary Gleason patterns and biochemical recurrence after prostatectomy: proposal for a modified Gleason scoring system.

    PubMed

    Trock, Bruce J; Guo, Charles C; Gonzalgo, Mark L; Magheli, Ahmed; Loeb, Stacy; Epstein, Jonathan I

    2009-10-01

    We investigated the relationship between the tertiary Gleason component in radical prostatectomy specimens and biochemical recurrence in what is to our knowledge the largest single institution cohort to date. We evaluated data on 3,230 men who underwent radical prostatectomy at our institution from 2000 to 2005. Tertiary Gleason component was defined as Gleason grade pattern 4 or greater for Gleason score 6 and Gleason grade pattern 5 for Gleason score 7 or 8. Biochemical recurrence curves for cancer with tertiary Gleason component were intermediate between those of cancer without a tertiary Gleason component in the same Gleason score category and cancer in the next higher Gleason score category. The only exception was that Gleason score 4 + 3 = 7 with a tertiary Gleason component behaved like Gleason score 8. The tertiary Gleason component independently predicted recurrence when factoring in radical prostatectomy Gleason score, radical prostatectomy stage and prostate specific antigen (HR 1.45, p = 0.029). Furthermore, the magnitude of the tertiary Gleason component effect on recurrence did not differ by Gleason score category (p = 0.593). Although the tertiary Gleason component is frequently included in pathology reports, it is routinely omitted in other situations, such as predictive nomograms, research studies and patient counseling. The current study adds to a growing body of evidence highlighting the importance of the tertiary Gleason component in radical prostatectomy specimens. Accordingly consideration should be given to a modified radical prostatectomy Gleason scoring system that incorporates tertiary Gleason component in intuitive fashion, including Gleason score 6, 6.5 (Gleason score 6 with tertiary Gleason component), 7 (Gleason score 3 + 4 = 7), 7.25 (Gleason score 3 + 4 = 7 with tertiary Gleason component), 7.5 (Gleason score 4 + 3), 8 (Gleason score 4 + 3 with tertiary Gleason component or Gleason score 8), 8.5 (Gleason score 8 with tertiary Gleason

  2. Cryptosporidium and Giardia removal by secondary and tertiary wastewater treatment.

    PubMed

    Taran-Benshoshan, Marina; Ofer, Naomi; Dalit, Vaizel-Ohayon; Aharoni, Avi; Revhun, Menahem; Nitzan, Yeshayahu; Nasser, Abidelfatah M

    2015-01-01

    Wastewater disposal may be a source of environmental contamination by Cryptosporidium and Giardia. This study was conducted to evaluate the prevalence of Cryptosporidium oocysts and Giardia cysts in raw and treated wastewater effluents. A prevalence of 100% was demonstrated for Giardia cysts in raw wastewater, at a concentration range of 10 to 12,225 cysts L(-1), whereas the concentration of Cryptosporidium oocysts in raw wastewater was 4 to 125 oocysts L(-1). The removal of Giardia cysts by secondary and tertiary treatment processes was greater than those observed for Cryptosporidium oocysts and turbidity. Cryptosporidium and Giardia were present in 68.5% and 76% of the tertiary effluent samples, respectively, at an average concentration of 0.93 cysts L(-1) and 9.94 oocysts L(-1). A higher detection limit of Cryptosporidium oocysts in wastewater was observed for nested PCR as compared to immune fluorescent assay (IFA). C. hominis was found to be the dominant genotype in wastewater effluents followed by C. parvum and C. andersoni or C. muris. Giardia was more prevalent than Cryptosporidium in the studied community and treatment processes were more efficient for the removal of Giardia than Cryptosporidium. Zoonotic genotypes of Cryptosporidium were also present in the human community. To assess the public health significance of Cryptosporidium oocysts present in tertiary effluent, viability (infectivity) needs to be assessed.

  3. Mudflow utilization for construction materials of tertiary irrigation canal lining

    NASA Astrophysics Data System (ADS)

    Azis, Subandiyah; Kustamar

    2017-11-01

    Mudflow in Siring Village, Sidoarjo Regency, Indonesia, has been in eruption since May 29, 2006. It still shows irregular large bursts which loaded in a sludge reservoir with capacity of 59 million m3. From 2007 until 2015, there were more than 20 studies which concluded that the mudflow could be used as a mixture of building materials. However, the studies were not detailed and needed further research. This research aims to investigate the use of mudflow as tertiary irrigation canal lining material. This research comes with several laboratory tests to obtain a mixture that is solid and water-resistant. The methods that were used are descriptive methods as follows: 1). Sampling of mudflow, to be analyzed in Material Testing Laboratory. 2). Sampling of soil at research site, to be analyzed in Soil Mechanics Laboratory 3). Mixing of materials which are consist of mudflow and other materials and doing strength test in the laboratory. 4). Installation of tertiary irrigation canal lining using materials that have been tested. 5). Observation of lining's strength inactive soil pressure-bearing and its impermeability. It is expected that the results of this research will be applied extensively throughout the tertiary irrigation canals, so mudflow can be utilized as raw materials that are environmentally friendly, which are able to help preserving the environment, also to reduce the removal of sand / rock in the river, which has been used for lining materials, that benefits in preventing damage to the river ecosystem.

  4. IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (Etbe) ...

    EPA Pesticide Factsheets

    In September 2016, EPA released the draft IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) for public comment and discussion. The draft assessment was reviewed internally by EPA and by other federal agencies and White House Offices before public release. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available. Accordingly, interagency comments and the interagency science consultation materials provided to other agencies, including interagency review drafts of the IRIS Toxicological Review of Ethyl Tertiary Butyl Ether are posted on this site. EPA is undertaking an new health assessment for ethyl tertiary butyl ether (ETBE) for the Integrated Risk Information System (IRIS). The outcome of this project will be a Toxicological Review and IRIS Summary of ETBE that will be entered on the IRIS database. IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment process, i.e., hazard identification and dose-response evaluation. IRIS assessments are used nationally and internationally in combination with specific situational exposure assessment infor

  5. Tertiary work-up of apparent treatment-resistant hypertension.

    PubMed

    Heimark, Sondre; Eskås, Per Anders; Mariampillai, Julian Eek; Larstorp, Anne Cecilie K; Høieggen, Aud; Fadl Elmula, Fadl Elmula M

    2016-10-01

    Treatment-resistant hypertension (TRH) has regained attention with development of new methods for treatment. However, the prevalence of TRH varies considerably from primary to secondary and tertiary care. We aimed to assess the prevalence of true TRH in a population of patients with apparent TRH in a university hospital setting of tertiary work-up and also investigate reasons for poor BP control and evaluate how work-up can be performed in general practice and secondary care. In this cohort study, we characterize a study population from Oslo Renal Denervation (RDN) Study. Patients (n = 83) were referred for RDN from secondary care. All patients underwent thorough medical investigation and 24-h ambulatory blood pressure measurements (24ABPM) after directly observed therapy (DOT). We then assessed reasons for lack of BP control. Fifty-three of 83 patients did not have true TRH. Main reasons for non-TRH were poor drug adherence (32%), secondary hypertension (30%) and white coat hypertension (15%). Forty-seven percent achieved blood pressure control after DOT with subsequent 24ABPM. There were otherwise no statistically significant differences in patient characteristics between the true TRH and the non-TRH group. Despite being a highly selected cohort referred for tertiary work-up of apparent TRH, BP control was achieved or secondary causes were identified in almost two thirds of the patients. Thorough investigation according to guidelines and DOT with subsequent 24ABPM is needed in work-up of apparent TRH.

  6. Early Intervention.

    ERIC Educational Resources Information Center

    Nathanson, Jeanne H., Ed.

    1992-01-01

    This theme issue focuses on early intervention. The four articles presented on this theme are: (1) "Deaf Infants, Hearing Mothers: A Research Report" (Kathryn P. Meadow-Orlans, and others), reporting findings on effects of auditory loss on early development; (2) "Maintaining Involvement of Inner City Families in Early Intervention Programs through…

  7. Frozen Chirality of Tertiary Aromatic Amides: Access to Enantioenriched Tertiary α-Amino Acid or Amino Alcohol without Chiral Reagent.

    PubMed

    Mai, Thi Thoa; Viswambharan, Baby; Gori, Didier; Guillot, Régis; Naubron, Jean-Valère; Kouklovsky, Cyrille; Alezra, Valérie

    2017-04-27

    One of the fundamental and intriguing aspects of life is the homochirality of the essential molecules. In this field, the absolute asymmetric synthesis of α-amino acids is a major challenge. Herein, we report access, by chemical means, to tertiary α-amino acid derivatives in up to 96 % ee without using any chiral reagent. In our strategy, the dynamic axial chirality of tertiary aromatic amides is frozen in a crystal and is responsible for the stereoselectivity of the subsequent steps. Furthermore, we could control the configuration of the final product by manually sorting and selecting the initial crystals. Based on vibrational circular dichroism studies, we could rationalize the observed stereoselectivity. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Stable isotope evidence for gradual environmental changes and species survivorship across the Cretaceous/Tertiary Boundary

    NASA Astrophysics Data System (ADS)

    Barrera, Enriqueta; Keller, Gerta

    1990-12-01

    High-resolution δ13C and δ18O records have been generated from analyses of the planktonic foraminiferal species Heterohelix globulosa and the benthonic foraminiferal taxon Lenticulina spp from 3 m of a cored section spanning the Cretaceous/Tertiary (K/T) boundary at Brazos River, Texas. These are the first stable isotope records across the K/T boundary based on monospecific and monogeneric foraminiferal samples. They show a gradual decrease in δ13C values of about 2.5 permil beginning at the K/T boundary, as defined by the first appearance of Tertiary planktonic foraminifera, and continuing 17-20 cm above the boundary, approximately 40,000 years later. Gradual 13C depletion contrasts with the sudden δ13C drop at the K/T boundary observed in many deep-sea sections. The surface-to-bottom δ13C gradient decreased to less than zero approximately 25,000-30,000 years after the K/T boundary and remained negative for at least the next 140,000 years. Concomitant with change in δ13C values is a gradual decrease of about 2.5 permil in δ18C values which has not been observed at other localities. This 18O depletion suggests changes in temperature and/or salinity in the earliest Paleocene Gulf of Mexico. No extinction of foraminiferal species is associated with the K/T boundary or the onset of 18O and 13C depletions. Instead, two phases of Cretaceous species extinctions occur. One extinction phase is below the K/T boundary and below the tsunami bed of Bourgeois et al. [1988] and may be linked to sea level regression and environmental perturbations. The second extinction phase coincides with the minimum in δ13C and δ18O values in the Early Danian (Zone P0/Pla) and appears directly related to environmental changes reflected in the isotopic record. H. globulosa, which is commonly present in Maastrichtian and Danian sediments, exhibits significantly lower 18O/16O and 13C/12C ratios in Tertiary sediments relative to specimens from Maastrichtian sediments, demonstrating the

  9. HIGH LEVELS OF MONOAROMATIC COMPOUNDS LIMIT THE USE OF SOLID-PHASE MICROEXTRACTION OF METHYL TERTIARY BUTYL ETHER AND TERTIARY BUTYL ALCOHOL

    EPA Science Inventory

    Recently, two papers reported the use of solid-phase microextraction (SPME) with polydimethylsiloxane(PDMS)/Carboxen fibers to determine trace levels of methyl tertiary butyl ether (MTBE) and tertiary butyl alcohol (tBA) in water. Attempts were made to apply this technique to th...

  10. Early Tertiary exhumation of the flank of a forearc basin, southwest Talkeetna Mountains, Alaska

    Bleick, Heather A.; Till, Alison B.; Bradley, Dwight C.; O’Sullivan, Paul; Wooden, Joe L.; Bradley, Dan B.; Taylor, Theresa A.; Friedman, Sam B.; Hults, Chad P.

    2012-01-01

    New geochronologic and thermochronologic data from rocks near Hatcher Pass, southwest Talkeetna Mountains, Alaska, record earliest Paleocene erosional and structural exhumation on the flank of the active Cook Inlet forearc basin. Cretaceous plutons shed sediments to the south, forming the Paleocene Arkose Ridge Formation. A Paleocene(?)-Eocene detachment fault juxtaposed ~60 Ma metamorphic rocks with the base of the Arkose Ridge Formation. U-Pb (analyzed by Sensitive High Resolution Ion Micro Probe Reverse Geometry (SHRIMP-RG)) zircon ages of the Cretaceous plutons, more diverse than previously documented, are 90.3±0.3 (previously considered a Jurassic unit), 79.1±1.0, 76.1±0.9, 75.8±0.7, 72.5±0.4, 71.9±0.3, 70.5±0.2, and 67.3±0.2 Ma. The cooling of these plutons occurred between 72 and 66 Ma (zircon fission track (FT) closure ~225°C). 40Ar/39Ar analyses of hornblende, white mica, and biotite fall into this range (Harlan and others, 2003). New apatite FT data collected on a west-to-east transect reveal sequential exhumation of fault blocks at 62.8±2.9, 54±2.5, 52.6±2.8, and 44.4±2.2 Ma. Plutonic clasts accumulated in the Paleocene Arkose Ridge Formation to the south. Detrital zircon (DZ) ages from the formation reflect this provenance: a new sample yielded one grain at 61 Ma, a dominant peak at 76 Ma, and minor peaks at 70, 80, 88, and 92 Ma. The oldest zircon is 181 Ma. Our apatite FT ages range from 35.1 to 50.9 Ma. Greenschist facies rocks now sit structurally between the plutonic rocks and the Arkose Ridge Formation. They are separated from plutonic rocks by the vertical Hatcher Pass fault and from the sedimentary rocks by a detachment fault. Ar cooling ages (Harlan and others, 2003) and new zircon FT ages for these rocks are concordant at 61-57 Ma, synchronous with deposition of the Arkose Ridge Formation. A cooling age of ~46 Ma came from one apatite FT sample. The metamorphic protolith (previously considered Jurassic) was deposited at or after 75 Ma based on new DZ data. The probability curve has a major peak from 76 to 102 Ma, minor peaks at 186, 197, 213, 303, 346, and 1,828, and two discordant grains at ~2,700 Ma. This is similar to DZ populations in the Valdez Group. The short period of time between deposition, metamorphism, and exhumation are consistent with metamorphism in a subduction-zone setting. Ductile and brittle structures in the metamorphic rocks are consistent with exhumation in a transtensional setting.

  11. Learning Factor Models of Students at Risk of Failing in the Early Stage of Tertiary Education

    ERIC Educational Resources Information Center

    Gray, Geraldine; McGuinness, Colm; Owende, Philip; Hofmann, Markus

    2016-01-01

    This paper reports on a study to predict students at risk of failing based on data available prior to commencement of first year. The study was conducted over three years, 2010 to 2012, on a student population from a range of academic disciplines, n=1,207. Data was gathered from both student enrollment data and an online, self-reporting,…

  12. Misuse of the Equals Sign: An Entrenched Practice from Early Primary Years to Tertiary Mathematics

    ERIC Educational Resources Information Center

    Vincent, Jill; Bardini, Caroline; Pierce, Robyn; Pearn, Catherine

    2015-01-01

    In this article, the authors begin by considering symbolic literacy in mathematics. Next, they examine the origins of misuse of the equals sign by primary and junior secondary students, where "=" has taken on an operational meaning. They explain that in algebra, students need both the operational and relational meanings of the equals…

  13. Early Occurrence Cases of Diabetes Mellitus: Clinical Picture in Two Major Tertiary Care Hospitals in India.

    PubMed

    Joseph, Nitin; Sharma, Shreya; Modi, Vinisha; Majunatha, Sanath; Siddiqui, Saad Arshad; Sinha, Mihika

    2018-04-24

    Type 1 diabetes mellitus (T1D) is one of the most common endocrine disease in childhood. However, very limited information is available on this disease. This study was done to assess risk factors, clinical features and management practices in T1D patients. A review of records of 39 T1D cases admitted over the past five years in two hospitals was done. The mean age at diagnosis among males was 19.9±10.3 years and among females was 12.3±7.5 years (t=2.614, p=0.013). Mean age at diagnosis of patients who were underweight (n=7) was 9.9±4.4 years, compared to 17.8±10.1 years among patients (n=32) with normal or overweight status (t=2.028, p=0.05). Family history of diabetes mellitus was present among 7(17.9%) cases. The most common symptoms among the cases were fatigue 22(56.4%), polyuria 19(48.7%) and polydipsia 18(46.1%). The most common sign was weight loss 27(69.2%). The most common complications were diabetic nephropathy and skin infections seen each among 10(25.6%) cases. Mean duration of T1D was significantly more among patients with diabetic nephropathy (p<0.001), compared to those without. Mean HbA1c value among patients was 12.9±2.7. It was significantly more among patients with diabetic ketoacidosis (DKA) (p=0.012). A short acting insulin was used in the management of T1D among 59.5% cases. The outcome of the management showed a loss of one patient who developed DKA. Routine growth monitoring and blood glucose analysis is required among the affected. The present study provides a database of patients with T1D in this region, and addresses several issues important to both patients and their care providers. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  14. Amphibians as indicators of early tertiary "out-of-India" dispersal of vertebrates.

    PubMed

    Bossuyt, F; Milinkovitch, M C

    2001-04-06

    Sixty-five million years ago, massive volcanism produced on the India-Seychelles landmass the largest continental lava deposit (Deccan Traps) of the past 200 million years. Using a molecular clock-independent approach for inferring dating information from molecular phylogenies, we show that multiple lineages of frogs survived Deccan Traps volcanism after millions of years of isolation on drifting India. The collision between the Indian and Eurasian plates was followed by wide dispersal of several of these lineages. This "out-of-India" scenario reveals a zoogeographical pattern that might reconcile paleontological and molecular data in other vertebrate groups.

  15. Early Experiences with Mobile Electronic Health Records Application in a Tertiary Hospital in Korea

    PubMed Central

    Park, Minah; Hong, Eunseok; Kim, Sunhyu; Ahn, Ryeok; Hong, Jungseok; Song, Seungyeol; Kim, Tak; Kim, Jeongkeun; Yeo, Seongwoon

    2015-01-01

    Objectives Recent advances in mobile technology have opened up possibilities to provide strongly integrated mobile-based services in healthcare and telemedicine. Although the number of mobile Electronic Health Record (EHR) applications is large and growing, there is a paucity of evidence demonstrating the usage patterns of these mobile applications by healthcare providers. This study aimed to illustrate the deployment process for an integrated mobile EHR application and to analyze usage patterns after provision of the mobile EHR service. Methods We developed an integrated mobile application that aimed to enhance the mobility of healthcare providers by improving access to patient- and hospital-related information during their daily medical activities. The study included mobile EHR users who accessed patient healthcare records between May 2013 and May 2014. We performed a data analysis using a web server log file analyzer from the integrated EHR system. Cluster analysis was applied to longitudinal user data based on their application usage pattern. Results The mobile EHR service named M-UMIS has been in service since May 2013. Every healthcare provider in the hospital could access the mobile EHR service and view the medical charts of their patients. The frequency of using services and network packet transmission on the M-UMIS increased gradually during the study period. The most frequently accessed service in the menu was the patient list. Conclusions A better understanding regarding the adoption of mobile EHR applications by healthcare providers in patient-centered care provides useful information to guide the design and implementation of future applications. PMID:26618036

  16. Topological constraints are major determinants of tRNA tertiary structure and dynamics and provide basis for tertiary folding cooperativity

    PubMed Central

    Mustoe, Anthony M.; Brooks, Charles L.; Al-Hashimi, Hashim M.

    2014-01-01

    Recent studies have shown that basic steric and connectivity constraints encoded at the secondary structure level are key determinants of 3D structure and dynamics in simple two-way RNA junctions. However, the role of these topological constraints in higher order RNA junctions remains poorly understood. Here, we use a specialized coarse-grained molecular dynamics model to directly probe the thermodynamic contributions of topological constraints in defining the 3D architecture and dynamics of transfer RNA (tRNA). Topological constraints alone restrict tRNA's allowed conformational space by over an order of magnitude and strongly discriminate against formation of non-native tertiary contacts, providing a sequence independent source of folding specificity. Topological constraints also give rise to long-range correlations between the relative orientation of tRNA's helices, which in turn provides a mechanism for encoding thermodynamic cooperativity between distinct tertiary interactions. These aspects of topological constraints make it such that only several tertiary interactions are needed to confine tRNA to its native global structure and specify functionally important 3D dynamics. We further show that topological constraints are conserved across tRNA's different naturally occurring secondary structures. Taken together, our results emphasize the central role of secondary-structure-encoded topological constraints in defining RNA 3D structure, dynamics and folding. PMID:25217593

  17. Tertiary carbonate-dissolution cycles on the Sierra Leone Rise, eastern equatorial Atlantic Ocean

    Dean, W.E.; Gardner, J.V.; Cepek, P.

    1981-01-01

    Most of the Tertiary section on Sierra Leone Rise off northwest Africa consists of chalk, marl, and limestone that show cyclic alterations of clay-rich and clay-poor beds about 20-60 cm thick. On the basis of biostratigraphic accumulation rates, the cycles in Oligocene and Miocene chalk have periods which average about 44,000 years, and those in Eocene siliceous limestone have periods of 4000-27,000 years. Several sections were sampled in detail to further define the cycles in terms of content of CaCO3, clay minerals, and relative abundances of calcareous nannofossils. Extending information gained by analyses of Pleistocene cores from the continental margin of northwest Africa to the Tertiary cycles on Sierra Leone Rise, both dilution by noncarbonate material and dissolution of CaCO3 could have contributed to the observed relative variations in clay and CaCO3. However, dissolution of CaCO3 as the main cause of the carbonate-clay cycles on the Sierra Leone Rise, rather than dilution by clay, is suggested by the large amount of change (several thousand percent) in terrigenous influx required to produce the observed variations in amount of clay and by the marked increase in abundance of dissolution-resistant discoasters relative to more easily dissolved coccoliths in low-carbonate parts of cycles. The main cause of dissolution of CaCO3 was shoaling of the carbonate compensation depth (CCD) during the early Neogene and climatically induced fluctuations in the thickness of Antarctic Bottom Water. ?? 1981.

  18. Geologic Map of Prescott National Forest and the Headwaters of the Verde River, Yavapai and Coconino Counties, Arizona

    DeWitt, Ed; Langenheim, V.E.; Force, Eric; Vance, R.K.; Lindberg, P.A.; Driscoll, R.L.

    2008-01-01

    This 1:100,000-scale digital geologic map details the complex Early Proterozoic metavolcanic and plutonic basement of north-central Arizona; shows the mildly deformed cover of Paleozoic rocks; reveals where Laramide to mid-Tertiary plutonic rocks associated with base- and precious-metals deposits are exposed; subdivides the Tertiary volcanic rocks according to chemically named units; and maps the Pliocene to Miocene fill of major basins. Associated digital files include more than 1,300 geochemical analyses of all rock units; 1,750 logs of water wells deeper than 300 feet; and interpreted logs of 300 wells that define the depth to basement in major basins. Geophysically interpreted buried features include normal faults defining previous unknown basins, mid-Tertiary intrusive rocks, and half-grabens within shallow bains.

  19. Complementation of biotransformations with chemical C-H oxidation: copper-catalyzed oxidation of tertiary amines in complex pharmaceuticals.

    PubMed

    Genovino, Julien; Lütz, Stephan; Sames, Dalibor; Touré, B Barry

    2013-08-21

    The isolation, quantitation, and characterization of drug metabolites in biological fluids remain challenging. Rapid access to oxidized drugs could facilitate metabolite identification and enable early pharmacology and toxicity studies. Herein, we compared biotransformations to classical and new chemical C-H oxidation methods using oxcarbazepine, naproxen, and an early compound hit (phthalazine 1). These studies illustrated the low preparative efficacy of biotransformations and the inability of chemical methods to oxidize complex pharmaceuticals. We also disclose an aerobic catalytic protocole (CuI/air) to oxidize tertiary amines and benzylic CH's in drugs. The reaction tolerates a broad range of functionalities and displays a high level of chemoselectivity, which is not generally explained by the strength of the C-H bonds but by the individual structural chemotype. This study represents a first step toward establishing a chemical toolkit (chemotransformations) that can selectively oxidize C-H bonds in complex pharmaceuticals and rapidly deliver drug metabolites.

  20. Listeriosis in pregnancy: a secular trend in a tertiary referral hospital in Barcelona.

    PubMed

    Sisó, C; Goncé, A; Bosch, J; Salvia, M D; Hernández, S; Figueras, F

    2012-09-01

    The purpose of this study was to describe the variation in listeriosis infection incidence during pregnancy over a 25-year period based on salient clinical and laboratory features compiled in a tertiary referral hospital and to depict the clinical characteristics of these cases. A cohort was created of all cases of listeriosis in pregnant women or their neonates (early-onset form) diagnosed between 1985 and 2010. Forty-three cases of perinatal listeriosis were diagnosed among the 82,320 hospitalised pregnant women (incidence 0.5‰). Whereas the incidence remained almost constant at 0.24‰ until 2000, an increasing incidence was observed from then on, reaching 0.86‰ during the last years of the study period. A four-fold increase in listeriosis rate during pregnancy has occurred in recent years, with poorer outcome for those cases occurring before 28 weeks and for those in which early antibiotic treatment was not provided. These results should raise the awareness of the agencies and professionals involved in prenatal care.

  1. Addressing indigenous health workforce inequities: A literature review exploring 'best' practice for recruitment into tertiary health programmes

    PubMed Central

    2012-01-01

    Introduction Addressing the underrepresentation of indigenous health professionals is recognised internationally as being integral to overcoming indigenous health inequities. This literature review aims to identify 'best practice' for recruitment of indigenous secondary school students into tertiary health programmes with particular relevance to recruitment of Māori within a New Zealand context. Methodology/methods A Kaupapa Māori Research (KMR) methodological approach was utilised to review literature and categorise content via: country; population group; health profession ffocus; research methods; evidence of effectiveness; and discussion of barriers. Recruitment activities are described within five broad contexts associated with the recruitment pipeline: Early Exposure, Transitioning, Retention/Completion, Professional Workforce Development, and Across the total pipeline. Results A total of 70 articles were included. There is a lack of published literature specific to Māori recruitment and a limited, but growing, body of literature focused on other indigenous and underrepresented minority populations. The literature is primarily descriptive in nature with few articles providing evidence of effectiveness. However, the literature clearly frames recruitment activity as occurring across a pipeline that extends from secondary through to tertiary education contexts and in some instances vocational (post-graduate) training. Early exposure activities encourage students to achieve success in appropriate school subjects, address deficiencies in careers advice and offer tertiary enrichment opportunities. Support for students to transition into and within health professional programmes is required including bridging/foundation programmes, admission policies/quotas and institutional mission statements demonstrating a commitment to achieving equity. Retention/completion support includes academic and pastoral interventions and institutional changes to ensure safer

  2. Addressing indigenous health workforce inequities: a literature review exploring 'best' practice for recruitment into tertiary health programmes.

    PubMed

    Curtis, Elana; Wikaire, Erena; Stokes, Kanewa; Reid, Papaarangi

    2012-03-15

    Addressing the underrepresentation of indigenous health professionals is recognised internationally as being integral to overcoming indigenous health inequities. This literature review aims to identify 'best practice' for recruitment of indigenous secondary school students into tertiary health programmes with particular relevance to recruitment of Māori within a New Zealand context. METHODOLOGY/METHODS: A Kaupapa Māori Research (KMR) methodological approach was utilised to review literature and categorise content via: country; population group; health profession focus; research methods; evidence of effectiveness; and discussion of barriers. Recruitment activities are described within five broad contexts associated with the recruitment pipeline: Early Exposure, Transitioning, Retention/Completion, Professional Workforce Development, and Across the total pipeline. A total of 70 articles were included. There is a lack of published literature specific to Māori recruitment and a limited, but growing, body of literature focused on other indigenous and underrepresented minority populations.The literature is primarily descriptive in nature with few articles providing evidence of effectiveness. However, the literature clearly frames recruitment activity as occurring across a pipeline that extends from secondary through to tertiary education contexts and in some instances vocational (post-graduate) training. Early exposure activities encourage students to achieve success in appropriate school subjects, address deficiencies in careers advice and offer tertiary enrichment opportunities. Support for students to transition into and within health professional programmes is required including bridging/foundation programmes, admission policies/quotas and institutional mission statements demonstrating a commitment to achieving equity. Retention/completion support includes academic and pastoral interventions and institutional changes to ensure safer environments for indigenous

  3. Tertiary survey in polytrauma patients should be an ongoing process.

    PubMed

    Ferree, Steven; Houwert, Roderick M; van Laarhoven, Jacqueline J E M; Smeeing, Diederik P J; Leenen, Luke P H; Hietbrink, Falco

    2016-04-01

    Due to prioritisation in the initial trauma care, non-life threatening injuries can be overlooked or temporally neglected. Polytrauma patients in particular might be at risk for delayed diagnosed injuries (DDI). Studies that solely focus on DDI in polytrauma patients are not available. Therefore the aim of this study was to analyze DDI and determine risk factors associated with DDI in polytrauma patients. In this single centre retrospective cohort study, patients were considered polytrauma when the Injury Severity Score was ≥ 16 as a result of injury in at least 2 body regions. Adult polytrauma patients admitted from 2007 until 2012 were identified. Hospital charts were reviewed to identify DDI. 1416 polytrauma patients were analyzed of which 12% had DDI. Most DDI were found during initial hospital admission after tertiary survey (63%). Extremities were the most affected regions for all types of DDI (78%) with the highest intervention rate (35%). Most prevalent DDI were fractures of the hand (54%) and foot (38%). In 2% of all patients a DDI was found after discharge, consisting mainly of injuries other than a fracture. High energy trauma mechanism (OR 1.8, 95% CI 1.2-2.7), abdominal injury (OR 1.5, 95% CI 1.1-2.1) and extremity injuries found during initial assessment (OR 2.3, 95% CI 1.6-3.3) were independent risk factors for DDI. In polytrauma patients, most DDI were found during hospital admission but after tertiary survey. This demonstrates that the tertiary survey should be an ongoing process and thus repeated daily in polytrauma patients. Most frequent DDI were extremity injuries, especially injuries of the hand and foot. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. From Ramachandran Maps to Tertiary Structures of Proteins.

    PubMed

    DasGupta, Debarati; Kaushik, Rahul; Jayaram, B

    2015-08-27

    Sequence to structure of proteins is an unsolved problem. A possible coarse grained resolution to this entails specification of all the torsional (Φ, Ψ) angles along the backbone of the polypeptide chain. The Ramachandran map quite elegantly depicts the allowed conformational (Φ, Ψ) space of proteins which is still very large for the purposes of accurate structure generation. We have divided the allowed (Φ, Ψ) space in Ramachandran maps into 27 distinct conformations sufficient to regenerate a structure to within 5 Å from the native, at least for small proteins, thus reducing the structure prediction problem to a specification of an alphanumeric string, i.e., the amino acid sequence together with one of the 27 conformations preferred by each amino acid residue. This still theoretically results in 27(n) conformations for a protein comprising "n" amino acids. We then investigated the spatial correlations at the two-residue (dipeptide) and three-residue (tripeptide) levels in what may be described as higher order Ramachandran maps, with the premise that the allowed conformational space starts to shrink as we introduce neighborhood effects. We found, for instance, for a tripeptide which potentially can exist in any of the 27(3) "allowed" conformations, three-fourths of these conformations are redundant to the 95% confidence level, suggesting sequence context dependent preferred conformations. We then created a look-up table of preferred conformations at the tripeptide level and correlated them with energetically favorable conformations. We found in particular that Boltzmann probabilities calculated from van der Waals energies for each conformation of tripeptides correlate well with the observed populations in the structural database (the average correlation coefficient is ∼0.8). An alpha-numeric string and hence the tertiary structure can be generated for any sequence from the look-up table within minutes on a single processor and to a higher level of accuracy

  5. Optomechanical design and testing of the VLT tertiary mirrors

    NASA Astrophysics Data System (ADS)

    Bollinger, Wolfgang; Juranek, Hans J.; Schulte, Stefan; May, K.; Michel, Alain

    2000-07-01

    The Tertiary Mirrors for the ESO Very Large Telescope project consist of four optical flats (elliptical, 890 X 1260 mm2). The achieved opto-mechanical design is challenging since it provides high optical overall quality combined with high stiffness (70 Hz Eigenfrequency) and low mass (total mass of 180 kg for the complete unit). Schott (Mainz, Germany) produces the lightweight Zerodur blanks. Carl Zeiss has designed and manufactured the mirror and its support cell. Last not least it became necessary to install the biggest testing equipment for flats in Europe to guarantee for a scientifically correct verification of the quality of the complete unit. All four mirrors have been delivered to ESO.

  6. An exploration of gender differences in tertiary mathematics

    NASA Astrophysics Data System (ADS)

    Watson, Jane M.

    1989-02-01

    Data from 400 students in a tertiary mathematics course were analysed to explore gender differences on a number of variables associated with learning mathematics. It was concluded that while differences did occur on variables associated with confidence, self-concept, test anxiety and quantitative ability indicating a detrimental effect for women, compensating behaviour by women, including increased assignment work and tutorial attendance, resulted in comparable final course performance for women and men. These findings are discussed in light of participation rates of women in mathematics.

  7. Facile solvolysis of a surprisingly twisted tertiary amide

    SciT

    Bloomfield, Aaron J.; Chaudhuri, Subhajyoti; Mercado, Brandon Q.

    2016-01-05

    In this study, a bicyclo[2.2.2]octane derivative containing both a tertiary amide and a methyl ester was shown crystallographically to adopt a conformation in which the amide is in the cis configuration, which is sterically disfavored, but electronically favored. The steric strain induces a significant torsion (15.9°) of the amide, thereby greatly increasing the solvolytic lability of the amide to the extent that we see competitive amide solvolysis in the presence of the normally more labile methyl ester also present in the molecule.

  8. Ignition of global wildfires at the Cretaceous/Tertiary boundary

    NASA Technical Reports Server (NTRS)

    Melosh, H. J.; Schneider, N. M.; Zahnle, K. J.; Latham, D.

    1990-01-01

    The recent discovery of an apparently global soot layer at the Cretaceous/Tertiary boundary indicates that global wildfires were somehow ignited by the impact of a comet or asteroid. It is shown here that the thermal radiation produced by the ballistic reentry of ejecta condensed from the vapor plume of the impact could have increased the global radiation flux by factors of 50 to 150 times the solar input for periods ranging from one to several hours. This great increase in thermal radiation may have been responsible for the ignition of global wildfires, as well as having deleterious effects on unprotected animal life.

  9. Proximal Cretaceous-Tertiary boundary impact deposits in the Caribbean

    NASA Technical Reports Server (NTRS)

    Hildebrand, Alan R.; Boynton, Willam V.

    1990-01-01

    Trace element, isotopic, and mineralogic studies indicate that the proposed impact at the Cretaceous-Tertiary boundary occurred in an ocean basin, although a minor component of continental material is required. The size and abundance of shocked minerals and the restricted geographic occurrence of the ejecta layer and impact-wave deposits suggest an impact between the Americas. Coarse boundary sediments at sites 151 and 153 in the Colombian Basin and 5- to 450-meter-thick boundary sediments in Cuba may be deposits of a giant wave produced by a nearby oceanic impact.

  10. Financial impact of tertiary care in an academic medical center.

    PubMed

    Huber, T S; Carlton, L M; O'Hern, D G; Hardt, N S; Keith Ozaki, C; Flynn, T C; Seeger, J M

    2000-06-01

    To analyze the financial impact of three complex vascular surgical procedures to both an academic hospital and a department of surgery and to examine the potential impact of decreased reimbursements. The cost of providing tertiary care has been implicated as one potential cause of the financial difficulties affecting academic medical centers. Patients undergoing revascularization for chronic mesenteric ischemia, elective thoracoabdominal aortic aneurysm repair, and treatment of infected aortic grafts at the University of Florida were compared with those undergoing elective infrarenal aortic reconstruction and carotid endarterectomy. Hospital costs and profit summaries were obtained from the Clinical Resource Management Office. Departmental costs and profit summary were estimated based on the procedural relative value units (RVUs), the average clinical cost per RVU ($33.12), surgeon charges, and the collection rate for the vascular surgery division (30.2%) obtained from the Faculty Group Practice. Surgeon work effort was analyzed using the procedural work RVUs and the estimated total care time. The analyses were performed for all payors and the subset of Medicare patients, and the potential impact of a 15% reduction in hospital and physician reimbursement was analyzed. Net hospital income was positive for all but one of the tertiary care procedures, but net losses were sustained by the hospital for the mesenteric ischemia and infected aortic graft groups among the Medicare patients. In contrast, the estimated reimbursement to the department of surgery for all payors was insufficient to offset the clinical cost of providing the RVUs for all procedures, and the estimated losses were greater for the Medicare patients alone. The surgeon work effort was dramatically higher for the tertiary care procedures, whereas the reimbursement per work effort was lower. A 15% reduction in reimbursement would result in an estimated net loss to the hospital for each of the tertiary

  11. Halitosis amongst students in tertiary institutions in Lagos state.

    PubMed

    Arinola, J E; Olukoju, O O

    2012-12-01

    Halitosis is defined as a noticeable unpleasant odor from the mouth. It is a medico-social problem that affects a significant number of people around the world. Research reveals that nearly 50% of the adult population has halitosis. To determine level of awareness of halitosis and prevalence of the condition amongst students in tertiary institutions as a baseline survey. For this project, 100 students from three tertiary institutions in Lagos state were chosen: University of Lagos, Lagos State University, Ojo campus and Yaba College of Technology. A semi-structured questionnaire and practical testing/diagnostic tool were utilized. Data collected was collated and analyzed using Microsoft Excel 2007 and SPSS statistical software. Most of the respondents were single and Christian. Level of awareness of halitosis was high. Results showed that 15%, 2% and 22% from UNILAG, LASU and YCT respectively said they had halitosis. Using the diagnostic tool, 6%, 8% and 2% respectively were positive for halitosis. There is high level of awareness of halitosis among the respondents. The prevalence of the disorder is low, however, it is recommended that enlightenment campaigns be mounted in schools to improve level of awareness and treatment seeking.

  12. IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (Etbe) ...

    EPA Pesticide Factsheets

    In August 2013, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for ETBE to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in comments on the following: Draft literature search strategies The approach for identifying studies The screening process for selecting pertinent studies The resulting list of pertinent studies Preliminary evidence tables The process for selecting studies to include in evidence tables The quality of the studies in the evidence tables The literature search strategy, which describes the processes for identifying scientific literature, contains the studies that EPA considered and selected to include in the evidence tables. The preliminary evidence tables and exposure-response arrays present the key study data in a standardized format. The evidence tables summarize the available critical scientific literature. The exposure-response figures provide a graphical representation of the responses at different levels of exposure for each study in the evidence table. The draft Toxicological Review of Ethyl Tertiary Butyl Ether provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to ethyl tertiary butyl ether.

  13. Tertiary oil discoveries whet explorer interest off Tunisia

    SciT

    Long, M.

    Prospects for increased Tertiary oil production in the S. Mediterranean have brightened with discoveries off Tunisia, but more evaluation is needed before commercial potential is known. Several groups of U.S. and European companies have tested oil in the relatively unexplored Miocene in the Gulf of Hannamet. These include groups operated by Buttes Resources Tunisia, Elf-Aquitaine Tunisia, and Shell Tunirex. Oil test rates of 1,790 to 1,800 bpd have been reported by the Buttes group in 2 Gulf of Hammamet wells. The initial discovery probably was the first Tertiary oil ever tested in that part of the Mediterranean. The discoveries havemore » helped boost exploratory interest in the northern waters of Tunisia and northeast toward Sicily. There are reports more U.S. and European companies are requesting exploration permits from the government of Tunisia. Companies with permits are planning new exploration for 1978. Probably the most significant discovery to date has been the Buttes group's 1 Jasmine (2 BGH). The group tested high-quality 39.5'-gravity oil at a rate of 1,790 bpd. Test flow was from the Sabri Sand at 6,490 to 6,590 ft. The well was drilled in 458 ft of water.« less

  14. Burial history of Upper Cretaceous and Tertiary rocks interpreted from vitrinite reflectance, northern Green River basin, Wyoming

    SciT

    Dickinson, W.W.; Law, B.E.

    1985-05-01

    The burial history of Upper Cretaceous and Tertiary rocks in the northern Green River basin is difficult to reconstruct for three reasons: (1) most of these rocks do not crop out, (2) there are few stratigraphic markers in the subsurface, and (3) regional uplift beginning during the Pliocene caused erosion that removed most upper Tertiary rocks. To understand better the burial and thermal history of the basin, published vitrinite reflectance (R/sub o/) data from three wells were compared to TTI (time-temperature index) maturation units calculated from Lopatin reconstructions. For each well, burial reconstructions were made as follows. Maximum depth ofmore » burial was first estimated by stratigraphic and structural evidence and by extrapolation to a paleosurface intercept of R/sub o/ = 0.2%. This burial was completed by early Oligocene (35 Ma), after which there was no net deposition. The present geothermal gradient in each well as used because there is no geologic evidence for elevated paleotemperature gradients. Using these reconstructions, calculated TTI units agreed with measured R/sub o/ values when minor adjustments were made to the estimated burial depths. Reconstructed maximum burials were deeper than present by 2500-3000 ft (762-914 m) in the Pacific Creek area, by 4000-4500 ft (1219-1372 m) in the Pinedale area, and by 0-1000 ft (0-305 m) in the Merna area. However, at Pinedale geologic evidence can only account for about 3000 ft (914 m) of additional burial. This discrepancy is explained by isoreflectance lines, which parallel the Pinedale anticline and indicate that approximately 2000 ft (610 m) of structural relief occurred after maximum burial. In other parts of the basin, isoreflectance lines also reveal significant structural deformation after maximum burial during early Oligocene to early Pliocene time.« less

  15. Destructive bone disease in early syphilis.

    PubMed

    Dismukes, W E; Delgado, D G; Mallernee, S V; Myers, T C

    1976-12-06

    Although destructive bone disease is a well-known complication of tertiary syphilis, osteitis or osteomyelitis are not commonly recognized as complications of early (primary or secondary) syphillis. A patient with secondary syphilis characterized by generalized lymphadenopathy, perianal condyloma lata, and positive rapid plasma reagin (RPR) and fluorescent treponemal antibody-absorption (FTA-ABS) tests also complained of headache, right should pain, and right anterior chest pain and swelling. Roentgenograms showed mottled osteolytic lesions consistent with previously described luetic bone disease. Biopsy confirmed the diagnosis of syphilitic osteomyelitis, and treatment with penicillin resulted in prompt resolution of symptoms.

  16. Early Rockets

    2004-04-15

    In addition to Dr. Robert Goddard's pioneering work, American experimentation in rocketry prior to World War II grew, primarily in technical societies. This is an early rocket motor designed and developed by the American Rocket Society in 1932.

  17. Biotic and abiotic transformations of methyl tertiary butyl ether (MTBE).

    PubMed

    Fischer, Axel; Oehm, Claudia; Selle, Michael; Werner, Peter

    2005-11-01

    Methyl tertiary butyl ether (MTBE) is a fuel additive which is used all over the world. In recent years it has often been found in groundwater, mainly in the USA, but also in Europe. Although MTBE seems to be a minor toxic, it affects the taste and odour of water at concentrations of < 30 microg/L. Although MTBE is often a recalcitrant compound, it is known that many ethers can be degraded by abiotic means. The aim of this study was to examine biotic and abiotic transformations of MTBE with respect to the particular conditions of a contaminated site (former refinery) in Leuna, Germany. Groundwater samples from wells of a contaminated site were used for aerobic and anaerobic degradation experiments. The abiotic degradation experiment (hydrolysis) was conducted employing an ion-exchange resin and MTBE solutions in distilled water. MTBE, tertiary butyl formate (TBF) and tertiary butyl alcohol (TBA) were measured by a gas chromatograph with flame ionisation detector (FID). Aldehydes and organic acids were respectively analysed by a gas chromatograph with electron capture detector (ECD) and high-performance ion chromatography (HPIC). Under aerobic conditions, MTBE was degraded in laboratory experiments. Only 4 of a total of 30 anaerobic experiments exhibited degradation, and the process was very slow. In no cases were metabolites detected, but a few degradation products (TBF, TBA and formic acid) were found on the site, possibly due to the lower temperatures in groundwater. The abiotic degradation of MTBE with an ion-exchange resin as a catalyst at pH 3.5 was much faster than hydrolysis in diluted hydrochloric acid (pH 1.0). Although the aerobic degradation of MTBE in the environment seems to be possible, the specific conditions responsible are widely unknown. Successful aerobic degradation only seems to take place if there is a lack of other utilisable compounds. However, MTBE is often accompanied by other fuel compounds on contaminated sites and anaerobic conditions

  18. Emotional Intelligence and the Conflict Resolution Repertoire of Couples in Tertiary Institutions in Imo State

    ERIC Educational Resources Information Center

    Nnodum, B. I.; Ugwuegbulam, C. N.; Agbaenyi, I. G.

    2016-01-01

    This study is a descriptive survey that investigated the relationship between emotional intelligence and conflict resolution repertoire of couples in tertiary institutions. A sample of 250 married people were drawn from the population of couples in tertiary institutions in Imo State. Two researcher made and validated instruments were used in…

  19. Why Do Tertiary Education Graduates Regret Their Study Program? A Comparison between Spain and the Netherlands

    ERIC Educational Resources Information Center

    Kucel, Aleksander; Vilalta-Bufi, Montserrat

    2013-01-01

    In this paper we investigate the determinants of regret of study program for tertiary education graduates in Spain and the Netherlands. These two countries differ in their educational system in terms of the tracking structure in their secondary education and the strength of their education-labor market linkages in tertiary education. Therefore, by…

  20. Students' Conceptions of the Particulate Nature of Matter at Secondary and Tertiary Level

    ERIC Educational Resources Information Center

    Ayas, Alipasa; Ozmen, Haluk; Calik, Muammer

    2010-01-01

    The aim of the present study is to elicit students' understanding of the particulate nature of matter via a cross-age study ranging from secondary to tertiary educational levels. A questionnaire with five-item open-ended questions was administered to 166 students from the secondary to tertiary levels of education. In light of the findings, it can…

  1. Understanding and Enhancing Learning Communities in Tertiary Education in Science and Engineering

    ERIC Educational Resources Information Center

    Forret, Michael; Eames, Chris; Coll, Richard

    2007-01-01

    This research aims to build upon current research in the area of teaching and learning at tertiary level and explore the nature of learning communities in tertiary science and engineering. This study uses a sociocultural approach to address the following question: "What are teachers' and learners' perceptions of the nature of the learning…

  2. Assessment of Social Media Utilization and Study Habit of Students of Tertiary Institutions in Katsina State

    ERIC Educational Resources Information Center

    Olutola, Adekunle Thomas; Olatoye, Olufunke Omotoke; Olatoye, Rafiu Ademola

    2016-01-01

    This study investigated assessment of social media utilization and study habits of students of tertiary institutions in Katsina State. The descriptive survey design was adopted for this study. Three hundred and eighty-one (381) students' of tertiary institutions in Katsina State were randomly selected for the study. Researchers'-designed…

  3. Tertiary Educators' Voices in Australia and South Africa: Experiencing and Engaging in African Music and Culture

    ERIC Educational Resources Information Center

    Joseph, Dawn

    2015-01-01

    Music tertiary educators can foster positive experiences that promote diversity, enhance intercultural and cross-cultural understanding through our teaching. Through findings of interview data of tertiary music educators' understandings of multicultural music practice at two South African universities and at an Australia university, I used…

  4. Is It Ever Too Late to Study? The Economic Returns on Late Tertiary Degrees in Sweden

    ERIC Educational Resources Information Center

    Hallsten, Martin

    2012-01-01

    This paper addresses the economic returns on tertiary degrees obtained in ages above 30 for individuals with upper-secondary schooling in light of current ideas on lifelong learning. Sweden is a case in point: Swedish tertiary education is open to older students, and labor market legislation supports employees who take a leave to study. The…

  5. The Impact of HECS Debt on Australian Students' Tertiary Academic Performance

    ERIC Educational Resources Information Center

    Birch, Elisa R.; Miller, Paul W.

    2006-01-01

    The Australian literature suggests that students' academic success in tertiary education is principally influenced by their university entrance score. Personal, secondary school and university characteristics have more minor impacts on tertiary outcomes. Little research has been undertaken into the relationship between students' marks and the…

  6. Chinese Tertiary Teachers' Goal Orientations for Teaching and Teaching Approaches: The Mediation of Teacher Engagement

    ERIC Educational Resources Information Center

    Yin, Hongbiao; Han, Jiying; Lu, Genshu

    2017-01-01

    This study investigated the effects of Chinese tertiary teachers' goal orientations for teaching on their approaches to teaching mediated by teacher engagement. In a survey of 597 Chinese tertiary teachers, the respondents placed particular emphasis on relational and mastery goals and expressed a preference for student-focused approaches to…

  7. Who Has to Pay for Their Education? Evidence from European Tertiary Education

    ERIC Educational Resources Information Center

    Lim, Gieyoung; Kim, Chong-Uk

    2013-01-01

    In this article, we investigate a positive tertiary education externality in 18 European countries. Using a simple Cobb-Douglas-type production function with constant returns to scale, we find that there are positive spillover effects from tertiary education in European countries. According to our model prediction, on average, 72,000 new employed…

  8. Problem-Based Learning in Tertiary Education: Teaching Old "Dogs" New Tricks?

    ERIC Educational Resources Information Center

    Yeo, Roland K.

    2005-01-01

    Purpose--The paper sets out to explore the challenges of problem-based learning (PBL) in tertiary education and to propose a framework with implications for practice and learning. Design/Methodology/Approach--A total of 18 tertiary students divided into three groups participated in the focus group discussions. A quantitative instrument was used as…

  9. Innovating in the Real World: Exploring Institutional Effects on Tertiary Teacher Innovations in New Zealand

    ERIC Educational Resources Information Center

    Lawrence, Belinda

    2018-01-01

    Innovation is a key goal of many tertiary education and distance learning providers. This research explores how teachers and educational designers across three New Zealand tertiary institutions worked to innovatively achieve teaching goals. A longitudinal design using the Cultural Historical Activity Theory (CHAT) framework explored the influence…

  10. Student Expectations of Tertiary Institutions: A Case Study of the Fiji National University (FNU)

    ERIC Educational Resources Information Center

    Khan, Shana Nigar

    2012-01-01

    Education is a human right and Fiji's tertiary education board recently declared that all tertiary institutions in Fiji must abide by the framework in order to meet student-customers' needs. The Fiji National University's (FNU's) destiny to be Fiji's leading higher education provider could be a reality if students and staff's expectations are…

  11. The Performance in Context Model: A 21st Century Tertiary Dance Teaching Pedagogy

    ERIC Educational Resources Information Center

    Stevens, Kym; Huddy, Avril

    2016-01-01

    Despite tertiary institutions acknowledging that reflective practice is an essential component of undergraduate dance teacher training, there is often a disparity between the tertiary students' reflective skills and the more sophisticated reflective ability needed to navigate the twenty-first-century workforce. This paper charts the evolution of a…

  12. Benchmarking Australian and New Zealand University Meta-Policy in an Increasingly Regulated Tertiary Environment

    ERIC Educational Resources Information Center

    Freeman, Brigid

    2014-01-01

    The agencies responsible for tertiary education quality assurance in Australia and New Zealand have established regulatory regimes that increasingly intersect with tertiary institution policy management. An examination of university meta-policies identified good practices guiding university policy and policy management. Most Australian and half of…

  13. Transition from Senior Secondary to Tertiary Languages Study: Student Attitudes in Three Sydney Schools

    ERIC Educational Resources Information Center

    Moloney, Robyn; Harbon, Lesley

    2014-01-01

    This paper reports on a small study of attitudes to tertiary language study amongst senior secondary language learners in three independent New South Wales schools. The study examines what elements of preparedness may be the most effective in supporting transition to tertiary study for this sample of languages students. An analysis of survey data…

  14. Standardization or Localization: A Study of Online Learning Programmes by Tertiary Institutions in Ghana

    ERIC Educational Resources Information Center

    Djan, Josephine; George, Babu

    2016-01-01

    Many universities in Ghana have had a desire to ensure equitable access to formal tertiary education for the growing number of the working public who have sought to improve or better their educational status in tertiary institutions. For many of these working public or individuals, it is almost impossible to stay off work to enrol in these…

  15. Framework of Assessment for the Evaluation of Thinking Skills of Tertiary Level Students

    ERIC Educational Resources Information Center

    Heng, Chan Swee; Ziguang, Yan

    2015-01-01

    In the 21st century, students are required to master thinking skills in order to deal with many situations that arise in the tertiary environment which later would translate into the workplace. Nowadays, thinking skills play a vital role in tertiary education. To provide an approach for teachers, this paper identifies a 4-step model that can be…

  16. An Investigation of Tertiary-Level Learning in Some Practical Physics Courses

    ERIC Educational Resources Information Center

    Wang, Weili; Coll, Richard K.

    2005-01-01

    Experimental physics is seen as an essential part of tertiary physics education. Students are supposed to develop practical skills and advance from closed "cookbook" experiments to open experiment and design experiment procedures independently. As a consequence tertiary practical physics courses increase in the level of challenge…

  17. Cost-Sharing Reform of Tertiary Education in China and Its Equity Impact

    ERIC Educational Resources Information Center

    Wang, Catherine Yan

    2013-01-01

    China has made huge strides in expanding access to higher education since the 1980s. The main approach to achieve mass higher education was cost-sharing reforms of tertiary education. This article examines the policy reforms that affected tuition, fees and subsidies for tertiary students since the end of the 1980s and looks at the effects in terms…

  18. On Progress of Mass Tertiary Education: Case of Lebanon, Kenya and Oman

    ERIC Educational Resources Information Center

    Liu, Zhimin; Mutinda, Gladys

    2016-01-01

    Mass higher education is a huge force to be reckoned with and its existence, already in the expansion of tertiary institutions is undeniable. This study will focus on three countries: Lebanon, Kenya and Oman. The purpose of this study is to evaluate mass tertiary education progress in these countries. It will synthesize data results of gross…

  19. A Comparison of Teacher and Lecturer Perspectives on the Transition from Secondary to Tertiary Mathematics Education

    ERIC Educational Resources Information Center

    Hong, Ye Yoon; Kerr, Suzanne; Klymchuk, Sergiy; McHardy, Johanna; Murphy, Priscilla; Spencer, Sue; Thomas, Michael O. J.; Watson, Peter

    2009-01-01

    The transition from school to tertiary study of mathematics comes under increasing scrutiny in research. This article reports on some findings from a project analysing the transition from secondary to tertiary education in mathematics. One key variable in this transition is the teacher or lecturer. This article deals with a small part of the data…

  20. A Collaborative Governance Approach to Improving Tertiary Education in Papua New Guinea

    ERIC Educational Resources Information Center

    Eldridge, Kaye; Larry, Lisa; Baird, Jeanette; Kavanamur, David

    2018-01-01

    Tertiary education in Papua New Guinea (PNG) is in a critical state, as the sector struggles to address increased demand for student places with severely curtailed capacity. Recent thinking about improving public services in PNG has emphasized "whole of sector" or collaborative governance. Such an approach in tertiary education has the…

  1. The Petasis Reaction: Microscale Synthesis of a Tertiary Amine Antifungal Analog

    ERIC Educational Resources Information Center

    Koroluk, Katherine J.; Jackson, Derek A.; Dicks, Andrew P.

    2012-01-01

    Students prepare a tertiary amine antifungal analog in an upper-level undergraduate organic laboratory. A microscale Petasis reaction is performed to generate a liquid compound readily characterized via IR and proton NMR spectroscopy. The biological relevance of the product is highlighted, with the tertiary amine scaffold being an important…

  2. The Missing Link in Australian Tertiary Education: Short-Cycle Higher Education

    ERIC Educational Resources Information Center

    Moodie, Gavin

    2003-01-01

    The blurring of the boundary between Australian vocational education and training and higher education is leading to a reconsideration of the current structure of Australian tertiary education. This paper starts with the main overlap of the Australian tertiary education sectors, diplomas and advanced diplomas. The ambiguous treatment of these…

  3. Challenges Faced by Key Stakeholders Using Educational Online Technologies in Blended Tertiary Environments

    ERIC Educational Resources Information Center

    Tuapawa, Kimberley

    2016-01-01

    Traditional learning spaces have evolved into dynamic blended tertiary environments (BTEs), providing a modern means through which tertiary education institutes (TEIs) can augment delivery to meet stakeholder needs. Despite the significant demand for web-enabled learning, there are obstacles concerning the use of EOTs, which challenge the…

  4. Blended Learning and Team Teaching: Adapting Pedagogy in Response to the Changing Digital Tertiary Environment

    ERIC Educational Resources Information Center

    Crawford, Renée; Jenkins, Louise

    2017-01-01

    Increased accessibility of advanced technology, the targeted use of online learning platforms, student flexible learning expectations and the pressures of faculty budget constraints and priorities have called into question the effectiveness of traditional tertiary teaching and learning models. The tertiary education context must evolve at a pace…

  5. Must a Developed Democratic State Fully Resource Any Tertiary Education for Its Citizens?

    ERIC Educational Resources Information Center

    Scholes, Vanessa

    2014-01-01

    This article takes a parsimonious conception of a developed State operating under a minimalist conception of democracy and asks whether such a State must fully resource any tertiary (post-compulsory) education for its citizens A key public policy barrier to arguing an absolute obligation for the State to resource any tertiary education is…

  6. Entrepreneurship Education in Delta State Tertiary Institution as a Means of Achieving National Growth and Development

    ERIC Educational Resources Information Center

    Osakwe, Regina N.

    2015-01-01

    This study examined entrepreneurship education in Delta Sate tertiary institutions as a means of national growth and development. Two research questions were asked to guide the study. The population comprised all the 1,898 academic staff in eight tertiary institutions in the state. A sample of 800 lecturers was drawn through the multi stage and…

  7. Evidence of reworked Cretaceous fossils and their bearing on the existence of Tertiary dinosaurs

    SciT

    Eaton, J.G.; Kirkland, J.I.; Doi, K.

    The Paleocene Shotgun fauna of Wyoming includes marine sharks as well as mammals. It has been suggested that the sharks were introduced from the Cannonball Sea. It is more likely that these sharks were reworked from a Cretaceous rock sequence that included both marine and terrestrial deposits as there is a mixture of marine and freshwater taxa. These taxa have not been recorded elsewhere after the Cretaceous and are not known from the Cannonball Formation. Early Eocene localities at Raven Ridge, Utah, similarly contain teeth of Cretaceous marine and freshwater fish, dinosaurs, and Eocene mammals. The Cretaceous teeth are wellmore » preserved, variably abraded, and serve to cast doubts on criteria recently used to claim that dinosaur teeth recovered from the Paleocene of Montana are not reworked. Another Eocene locality in the San Juan Basin has produced an Eocene mammalian fauna with diverse Cretaceous marine sharks. Neither the nature of preservation nor the degree of abrasion could be used to distinguish reworked from contemporaneous material. The mixed environments represented by the fish taxa and recognition of the extensive pre-Tertiary extinction of both marine and freshwater fish were employed to recognize reworked specimens.« less

  8. Clinico-radiographic study of odontogenic cysts at a tertiary care centre.

    PubMed

    Ali, Kamran; Munir, Faisal; Rehman, Abdur; Abbas, Iram; Ahmad, Nofil; Akhtar, Muhammad Usman

    2014-01-01

    Cysts of the jaws constitute an important pathology in the oral and maxillofacial region and are broadly classified as odontogenic and non-odontogenic. Objective of this study was to document the clinical and radiographic presentation of odontogenic cysts at a tertiary care centre. In this descriptive case-series, patients presenting with features of suspected cystic lesions of the jaws were investigated using radiographs and incisional biopsy. Subjects showing clinico- radiographic features of odontogenic cyst(s) with subsequent confirmation on histopathological examination were included. A total of 112 subjects were investigated for suspected jaw cysts and cystic diagnosis of odontogenic cysts was confirmed in 100 patients with 53 males (53%) and 47 females (47%). The age range of patients was from 12-55 years. Radicular cyst was the most commonly diagnosed odontogenic cyst (63%) followed by dentigerous cyst (22%) and odontogenickeratocyst (14%). Anterior maxilla was the most affected site (44%) followed by posterior mandible (30%). Odontogenic cysts constitute an established pathology affecting the jaws with varying frequency. This study augments the data cited from Western countries and re-emphasizes the need for early diagnosis and prompt management. It also highlights the differences in the presentation of odontogenic cysts as observed in the current series.

  9. Symptom Prevalence of Patients with Cancer in a Tertiary Cancer Center in Jordan.

    PubMed

    Alawneh, Alia; Anshasi, Huda; Khirfan, Ghaleb; Yaseen, Hesham; Quran, Anood

    2017-01-01

    Prevalence of symptoms experienced by patients with cancer was studied in different parts of the world. In Jordan, to the best of our knowledge, there is no published data on the prevalence of symptoms among patients with cancer. The aim of this study is to estimate the prevalence of symptoms among patients with cancer in Jordan. This was a secondary analysis of crosssectional survey that evaluate the psychometric properties of the Arabic version of the European Organization for Research and Treatment of Cancer Quality of Life 15 items Questionnaire for Palliative Care (EORTC QLQ-C15-PAL) among patients admitted to a tertiary cancer center in Jordan. A total of 175 patients with cancer participated in the study; 51.4% were males, 48.6 % were females, mean age of patients was 50 years. Median number of symptoms per patient was 6, interquartile range was 5-7. The majority of patients (143; 81%) had more than 3 non-pain symptoms each. The most frequently reported symptom was tiredness (82%), whereas the least prevalent symptom was depression (55%). Pain was prevalent in 71% of patients, median severity score was 50%. Patients with cancer suffer from a large constellation of symptoms, frequent assessment with a designated tool can help early identification of these symptoms and subsequent management. This highlights the need for integrated palliative services along with other health care provision.

  10. Building the Nonuniversity, Tertiary Care Center Hepatobiliary and Pancreatic Surgery Practice: Structural and Financial Considerations.

    PubMed

    Baker, Erin H; Siddiqui, Imran; Vrochides, Dionisios; Iannitti, David A; Martinie, John B; Rorabaugh, Lauren; Jeyarajah, D Rohan; Swan, Ryan Z

    2016-12-01

    Early in their careers, many new surgeons lack the background and experience to understand essential components needed to build a surgical practice. Surgical resident education is often devoid of specific instruction on the business of medicine and practice management. In particular, hepatobiliary and pancreatic (HPB) surgeons require many key components to build a successful practice secondary to significant interdisciplinary coordination and a scope of complex surgery, which spans challenging benign and malignant disease processes. In the following, we describe the required clinical and financial components for developing a successful HPB surgery practice in the nonuniversity tertiary care center. We discuss significant financial considerations for understanding community need and hospital investment, contract establishment, billing, and coding. We summarize the structural elements and key personnel necessary for establishing an effectual HPB surgical team. This article provides useful, essential information for a new HPB surgeon looking to establish a surgical practice. It also provides insight for health-care administrators as to the value an HPB surgeon can bring to a hospital or health-care system.

  11. [Streptococcal toxic shock syndrome: ten years' experience at a tertiary hospital].

    PubMed

    Vallalta-Morales, Manuel; Salavert-Lletí, Miguel; Artero-Mora, Arturo; Mahiques-Santos, Laura; Solaz-Moreno, Elena; Pérez-Bellés, Carmen

    2005-11-01

    In the last two decades there has been a reported increase in the incidence of streptococcal toxic shock syndrome (STSS). The objective of this study was to determine the clinical and epidemiological characteristics of this infection. Retrospective study of all cases of STSS diagnosed at a single tertiary hospital over the last ten years. We report 13 cases of STSS (8 men, mean age 62 years). The mean annual incidence was 0.19 episodes/100,000 population from 1994 to 1998 and 0.53 episodes/100,000 population from 1999 to 2003 (p = 0.059). All patients had at least one underlying disease and there were no intravenous drug users. The most common portals of entry were the skin and soft tissues (85%) and all but one patient had a positive blood culture. Two cases were nosocomial and five patients required surgery (amputation and/or debridement). There was a high mortality rate (85%) and a rapid course from onset to death; nine patients died within four days after establishing the diagnosis. The incidence of SSTS has increased over the last five years at our hospital. Elderly patients with underlying medical conditions were more susceptible to acquiring this infection. Early mortality was very high.

  12. Skin, a mirror reflecting diabetes mellitus: A longitudinal study in a tertiary care hospital in Gujarat.

    PubMed

    Vahora, Roshni; Thakkar, Sejal; Marfatia, Yogesh

    2013-07-01

    Diabetes mellitus (DM) is the most common of the endocrine disorders. Mucocutaneous manifestations of diabetes mellitus are many and vary from trivial to life-threatening. Sometimes, mucocutaneous disorders may herald the onset of diabetes. To study the pattern of mucocutaneous manifestations in diabetics and role of it in diagnosing diabetes mellitus and its complications. It was a longitudinal observational study of patients having diabetes with skin complaints attending skin outdoor department or admitted in wards for any reason in a tertiary care hospital. Total 300 patients were included in the study. Detailed history, clinical examination, and relevant investigations were done to diagnose the mucocutaneous disorders, diabetes, and diabetic complications. The data was analyzed by using Epi info software. Demographic profile shown majority of cases (78.66%) in more than 40 years of age with almost equal male and female preponderance. Mucocutaneous manifestations as presenting feature of diabetes were observed in 21.67% cases. Infections were most common in 119 (39.66%) cases, followed by acanthosis nigricans in 46 (15.33%) cases. Various associated complications like hypertension, retinopathy, hyperlipidemia, coronary artery disease, neuropathy, nephropathy, and diabetic ketoacidosis were observed in 160 (53.3%). Skin is the mirror, which reflects internal diseases; this aptly applies to skin and diabetes mellitus. Through awareness about cutaneous manifestations of DM, dermatologist can not only take credit for detecting DM but also facilitate early diagnosis of systemic complications of DM. This is immensely beneficial to patients in long run.

  13. Transition from tube feeding to oral feeding: experience in a tertiary care paediatric cardiology unit.

    PubMed

    Shine, Anne Marie; Finn, Daragh Gerard; Allen, Noeleen; McMahon, Colin J

    2018-05-02

    Home enteral tube feeding (HETF) is imperative for many infants and children with congenital heart disease (CHD). Tube weaning (TW) facilitates the progression from tube feeding to oral diet. There is limited literature on TW practices, protocols and success for children with CHD that have been tube fed. The objective of this study is to assess the process of weaning HETF in a tertiary referral centre for paediatric CHD. Specifically, we aimed to assess the duration of HETF, duration of TW and the interventions involved. We retrospectively reviewed the medical and dietetic records of all infants and children that were successfully weaned off HETF over a 12-month period from January 2015 to December 2015. There were 30 children included in the study, 9 boys and 21 girls. The diagnoses included 15 septal defects, 8 univentricular diagnosis and other diagnoses in 7 children. The median age at initiation of enteral tube feeding was 45 days (range 2-169). The median duration to wean from enteral tube feeding was 52 days (range 2-359). Number of dietetic consults required for successful TW varied among patients, median 5 (range 2-23). The number of days required for successful TW was associated with age and duration on HETF. Dietetic interventions included discontinuation of nutrient dense feeds, altering feed schedule and reduction of feed volume. Weaning HETF is possible in the outpatient setting. Early and frequent dietetic intervention is recommended to ensure prompt discontinuation of HETF when appropriate.

  14. Clinical features and overall survival among elderly cancer patients in a tertiary cancer center

    PubMed Central

    Antunes, Yuri Philippe Pimentel Vieira; Bugano, Diogo Diniz Gomes; del Giglio, Auro; Kaliks, Rafael Aliosha; Karnakis, Theodora; Pontes, Lucíola de Barros

    2015-01-01

    ABSTRACT Objective To evaluate the epidemiological profile and overall survival of a large population of elderly individuals diagnosed with solid tumors in a tertiary hospital. Methods This retrospective study included patients aged >65 years, diagnosed with solid tumors between January 2007 and December 2011, at Hospital Israelita Albert Einstein, São Paulo, Brazil. The medical records were reviewed to obtain information about clinical variables and overall survival. Results A total of 806 patients were identified, and 58.4% were male. Mean age was 74 years (65 to 99 years). The most common types were prostate (22%), colorectal (21%), breast (19%), and lung cancer (13%), followed by bladder (8%), pancreas (6%), and other types (11%). The majority of patients were diagnosed at early stage disease. After a median follow-up of 27 months (15 to 45 months), 29% of the patients (234/806) died, predominantly in the group older than 70 years. For the entire cohort, the median 2-year survival rate was 71%. Median overall survival was not reached within the study period. In a multivariate analysis, age (HR: 1.35; 95%CI: 1.25-1.45; p<0.001) and disease stage (HR: 1.93; 95%CI: 1.75-2.14; p<0.001) were independent negative predictors of poor survival. Conclusion The most prevalent tumors were prostate, colorectal, breast, and lung cancer, with the larger proportion diagnosed at initial stages, reflecting the great number of patients alive at last follow-up. PMID:26676269

  15. Incidence and risk factors of ventilator associated pneumonia in a tertiary care hospital.

    PubMed

    Charles, Mv Pravin; Easow, Joshy M; Joseph, Noyal M; Ravishankar, M; Kumar, Shailesh; Umadevi, Sivaraman

    2013-01-01

    Ventilator associated pneumonia (VAP) is a type of nosocomial pneumonia associated with increased morbidity and mortality. Knowledge about the incidence and risk factors is necessary to implement preventive measures to reduce mortality in these patients. A prospective study was conducted at a tertiary care teaching hospital for a period of 20 months from November 2009 to July 2011. Patients who were on mechanical ventilation (MV) for more than 48 hours were monitored at frequent intervals for development of VAP using clinical and microbiological criteria until discharge or death. Of the 76 patients, 18 (23.7%) developed VAP during their ICU stay. The incidence of VAP was 53.25 per 1,000 ventilator days. About 94% of VAP cases occurred within the first week of MV. Early-onset and late-onset VAP was observed in 72.2% and 27.8%, respectively. Univariate analysis showed chronic lung failure, H2 blockers usage, and supine head position were significant risk factors for VAP. Logistic regression revealed supine head position as an independent risk factor for VAP. VAP occurred in a sizeable number of patients on MV. Chronic lung failure, H2 blockers usage, and supine head position were the risk factors associated with VAP. Awareness about these risk factors can be used to inform simple and effective preventive measures.

  16. Assessment of pediatric residents burnout in a tertiary academic centre

    PubMed Central

    Jamjoom, Roaa S.; Park, Yoon S.

    2018-01-01

    Objectives: To study burnout among pediatric residents at King Abdulazaiz University Hospital in Jeddah, Saudi Arabia. Methods: This is a cross-sectional survey that was administered to all pediatric residents enrolled in the Saudi Paediatric Board program (PGY1-PGY4) in a large tertiary academic hospital in the Western region of Saudi Arabia (King Abdulaziz University Hospital). The survey were sent via E-mail to 50 registered general pediatric residents. Results: Seventy percent of the pediatric residents completed the survey. More than 70% of residents experiencing severe burnout. Forty-three percent suffering emotional exhaustion, 71.8% experiencing depersonalization and 40.6% suffering from low accomplishment. Conclusion: Burnout syndrome appear to be a serious threat to resident well-being in our program. Moreover, pediatric residents in our institute experienced higher levels of depersonalization than their peers nationally and internationally. PMID:29543309

  17. Mechanoreceptor Cells on the Tertiary Pulvini of Mimosa pudica L.

    PubMed Central

    Világi, Ildikó; Varró, Petra; Kristóf, Zoltán

    2007-01-01

    Special red cells were found on the adaxial surface of tertiary pulvini of Mimosa pudica and experiments performed to determine the origin and function of these cells. Using anatomical (light, scanning electron and transmission electron microscopy) and electrophysiological techniques, we have demonstrated that these red cells are real mechanoreceptor cells. They can generate receptor potential following mechanical stimuli and they are in connection with excitable motor cells (through plasmodesmata). We also provide evidence that these red cells are derived from stomatal subsidiary cells and not guard cells. As histochemical studies show red cells contain tannin, which is important in development of action potentials and movements of plants. These cells could be one of unidentified mechanoreceptors of mimosa. PMID:19517007

  18. Osmium Isotopic Composition of the Sumbar Cretaceous- Tertiary Boundary, Turkmenia

    NASA Astrophysics Data System (ADS)

    Meisel, T.; Krahenbuhl, U.; Nazarov, M. A.

    1992-07-01

    ., Barsukova L. D., Koselov G. M., Nizhegorodova I. V. and Amanniyazov K. N. (1988) The Cretaceous- Paleogene boundary in southern Turkmenia and its geochemical characteristics. Int. Geol. Rev. 30, 121-135. Esser B. K. and Turekian K. K. (1989) Osmium isotopic composition of the Raton Basin Cretaceous-Tertiary boundary interval. 70, 717. Kraehenbuehl U., Geissbuehler M., Buehler F. and Eberhardt P. (1988) The measurement of osmium isotopes in samples from a Cretaceous/Tertiary (K/T) section of the Raton Basin, USA. Meteoritics 23, 282. Lichte F. E., Wilson S. M., Brooks R. R., Reeves R. D., Holzbecher J. and Ryan D. E. (1986) New method for the measurement of osmium isotopes applied to a New Zealand Cretaceous/Tertiary boundary shale. Nature 322, 816-817. Luck J. M. and Turekian K. K. (1983) Osmium-^187/Osmium-^186 in manganese nodules and the Cretaceous-Tertiary boundary. Science 222, 613- 615. Turekian K. K. (1982) Potential of ^187Os/^186Os as a cosmic versus terrestrial indicator in high iridium layers of sedimentary strata. Geol. Bull. Am. Spec. Pap. 190, 243-249.

  19. Description, measurement and evaluation of tertiary-education food environments.

    PubMed

    Roy, R; Hebden, L; Kelly, B; De Gois, T; Ferrone, E M; Samrout, M; Vermont, S; Allman-Farinelli, M

    2016-05-01

    Obesity in young adults is an increasing health problem in Australia and many other countries. Evidence-based information is needed to guide interventions that reduce the obesity-promoting elements in tertiary-education environments. In a food environmental audit survey, 252 outlets were audited across seven institutions: three universities and four technical and further education institutions campuses. A scoring instrument called the food environment-quality index was developed and used to assess all food outlets on these campuses. Information was collated on the availability, accessibility and promotion of foods and beverages and a composite score (maximum score=148; higher score indicates healthier outlets) was calculated. Each outlet and the overall campus were ranked into tertiles based on their 'healthiness'. Differences in median scores for each outcome measure were compared between institutions and outlet types using one-way ANOVA with post hoc Scheffe's testing, χ 2 tests, Kruskal-Wallis H test and the Mann-Whitney U test. Binomial logistic regressions were used to compare the proportion of healthy v. unhealthy food categories across different types of outlets. Overall, the most frequently available items were sugar-sweetened beverages (20 % of all food/drink items) followed by chocolates (12 %), high-energy (>600 kJ/serve) foods (10 %), chips (10 %) and confectionery (10 %). Healthy food and beverages were observed to be less available, accessible and promoted than unhealthy options. The median score across all outlets was 72 (interquartile range=7). Tertiary-education food environments are dominated by high-energy, nutrient-poor foods and beverages. Interventions to decrease availability, accessibility and promotion of unhealthy foods are needed.

  20. Tertiary alphabet for the observable protein structural universe.

    PubMed

    Mackenzie, Craig O; Zhou, Jianfu; Grigoryan, Gevorg

    2016-11-22

    Here, we systematically decompose the known protein structural universe into its basic elements, which we dub tertiary structural motifs (TERMs). A TERM is a compact backbone fragment that captures the secondary, tertiary, and quaternary environments around a given residue, comprising one or more disjoint segments (three on average). We seek the set of universal TERMs that capture all structure in the Protein Data Bank (PDB), finding remarkable degeneracy. Only ∼600 TERMs are sufficient to describe 50% of the PDB at sub-Angstrom resolution. However, more rare geometries also exist, and the overall structural coverage grows logarithmically with the number of TERMs. We go on to show that universal TERMs provide an effective mapping between sequence and structure. We demonstrate that TERM-based statistics alone are sufficient to recapitulate close-to-native sequences given either NMR or X-ray backbones. Furthermore, sequence variability predicted from TERM data agrees closely with evolutionary variation. Finally, locations of TERMs in protein chains can be predicted from sequence alone based on sequence signatures emergent from TERM instances in the PDB. For multisegment motifs, this method identifies spatially adjacent fragments that are not contiguous in sequence-a major bottleneck in structure prediction. Although all TERMs recur in diverse proteins, some appear specialized for certain functions, such as interface formation, metal coordination, or even water binding. Structural biology has benefited greatly from previously observed degeneracies in structure. The decomposition of the known structural universe into a finite set of compact TERMs offers exciting opportunities toward better understanding, design, and prediction of protein structure.

  1. Tertiary alphabet for the observable protein structural universe

    PubMed Central

    Mackenzie, Craig O.; Zhou, Jianfu; Grigoryan, Gevorg

    2016-01-01

    Here, we systematically decompose the known protein structural universe into its basic elements, which we dub tertiary structural motifs (TERMs). A TERM is a compact backbone fragment that captures the secondary, tertiary, and quaternary environments around a given residue, comprising one or more disjoint segments (three on average). We seek the set of universal TERMs that capture all structure in the Protein Data Bank (PDB), finding remarkable degeneracy. Only ∼600 TERMs are sufficient to describe 50% of the PDB at sub-Angstrom resolution. However, more rare geometries also exist, and the overall structural coverage grows logarithmically with the number of TERMs. We go on to show that universal TERMs provide an effective mapping between sequence and structure. We demonstrate that TERM-based statistics alone are sufficient to recapitulate close-to-native sequences given either NMR or X-ray backbones. Furthermore, sequence variability predicted from TERM data agrees closely with evolutionary variation. Finally, locations of TERMs in protein chains can be predicted from sequence alone based on sequence signatures emergent from TERM instances in the PDB. For multisegment motifs, this method identifies spatially adjacent fragments that are not contiguous in sequence—a major bottleneck in structure prediction. Although all TERMs recur in diverse proteins, some appear specialized for certain functions, such as interface formation, metal coordination, or even water binding. Structural biology has benefited greatly from previously observed degeneracies in structure. The decomposition of the known structural universe into a finite set of compact TERMs offers exciting opportunities toward better understanding, design, and prediction of protein structure. PMID:27810958

  2. Coeliac disease screening is suboptimal in a tertiary gastroenterology setting.

    PubMed

    Iskandar, Heba; Gray, Darrell M; Vu, Hongha; Mirza, Faiz; Rude, Mary Katherine; Regan, Kara; Abdalla, Adil; Gaddam, Srinivas; Almaskeen, Sami; Mello, Michael; Marquez, Evelyn; Meyer, Claire; Bolkhir, Ahmed; Kanuri, Navya; Sayuk, Gregory; Gyawali, C Prakash

    2017-08-01

    Coeliac disease (CD) is widely prevalent in North America, but case-finding techniques currently used may not be adequate for patient identification. We aimed to determine the adequacy of CD screening in an academic gastroenterology (GI) practice. Consecutive initial visits to a tertiary academic GI practice were surveyed over a 3-month period as a fellow-initiated quality improvement project. All electronic records were reviewed to look for indications for CD screening according to published guidelines. The timing of screening was noted (before or after referral), as well as the screening method (serology or biopsy). Data were analysed to compare CD screening practices across subspecialty clinics. 616 consecutive patients (49±0.6 years, range 16-87 years, 58.5% females, 94% Caucasian) fulfilled inclusion criteria. CD testing was indicated in 336 (54.5%), but performed in only 145 (43.2%). The need for CD screening was highest in luminal GI and inflammatory bowel disease clinics, followed by biliary and hepatology clinics (p<0.0001); CD screening rate was highest in the luminal GI clinic (p=0.002). Of 145 patients screened, 4 patients (2.4%) had serology consistent with CD, of which 2 were proven by duodenal biopsy. Using this proportion, an additional 5 patients might have been diagnosed in 191 untested patients with indications for CD screening. More than 50% of patients in a tertiary GI clinic have indications for CD screening, but <50% of indicated cases are screened. Case-finding techniques therefore are suboptimal, constituting a gap in patient care and an important target for future quality improvement initiatives. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  3. Multidrug-resistant organisms in neonatal sepsis in two tertiary neonatal ICUs, Egypt.

    PubMed

    Awad, Hesham A; Mohamed, Maha H; Badran, Nabil F; Mohsen, Manal; Abd-Elrhman, Al-Sayed A

    2016-03-01

    Neonatal sepsis remains a serious problem in any neonatal intensive care unit (NICU). Bacterial organisms have developed increased resistance to commonly used antibiotics. Because not enough data are available from Egypt, the aim of the present study was to determine the causative bacteria and the level of their resistance to commonly used antibiotics in tertiary NICUs in Cairo, Egypt. A 3.5-year retrospective study was carried out at NICUs of the Children's Hospital of Ain Shams University and that of El-Hussein Hospital, Al-Azhar University, Egypt. Records of neonates were reviewed. All neonates with culture-proven sepsis were included in the study. Almost one-third of the admitted neonates (33.4%) were diagnosed as having neonatal sepsis, 32.25% of them culture-proven. Early/late onset sepsis was found in 35.4 and 64.6%, respectively. Gram-negative/gram-positive bacteria was found in 68 to 25.6%. Fungal infection was detected in 9% of the isolates. Escherichia coli was the main pathogen isolated in both early-onset sepsis (41.2%) and late-onset sepsis (24.5%). Overall, 77% of the isolates were multidrug-resistant (60% of gram-positive bacteria and 83.4% of gram-negative bacteria). Nearly 80% (79%) of mortality was caused by multidrug-resistant organisms. Gram-positive and gram-negative bacteria showed high resistance against commonly used antibiotics such as ampicillin, amoxicillin, cefotaxime, ceftriaxone, and gentamicin. There is an alarming increase in antibiotic resistance to the commonly used antibiotics. Continuous surveillance for antibiotic susceptibility is needed to ensure proper empirical therapy. Improvement of infection control practices, avoidance of irrational use of antibiotics, and revision of the protocols are mandatory in the prevention of neonatal sepsis.

  4. Study of Incidence and Prevalence of Musculoskeletal Anomalies in a Tertiary Care Hospital of Eastern India

    PubMed Central

    Mohanty, Biswa Bhusan; Sarangi, Rachita; Kumar, Sanjay; Mahapatra, Susanta Kumar; Chinara, Prafulla Kumar

    2014-01-01

    Introduction: Congenital anomalies or malformations are anatomical. Structural or functional defects present at birth leads to physical and mental disabilities. With the advent of newer drugs, infectious diseases have taken the backseat and congenital defects have emerged as an important cause of neonatal morbidity and mortality. In India, anomalies of musculoskeletal system have been most commonly reported. Aims and Objectives: With this in view, the present study was carried out to find the incidence and types of musculoskeletal defects in a tertiary care hospital in Eastern India. Various maternal factors were also correlated and analyzed. The purpose of this communication is to report these defects so as to help doctors and parents to prevent unexpected fetal loss and better parental counseling. Materials and Methods: This study was done in the Department of Obstetrics and Gynaecology in association with Department of Paediatrics of a tertiary care hospital in Odisha from for a period of 1 year. The newborns were examined within 1st three days of delivery for congenital malformations. The study group included all live borns along with still borns after 28 weeks of gestation or those dead babies whose weight was about 1kg. A thorough physical examination from head to toe was done to look for musculoskeletal defects within 24hrs of delivery. Observation and Results: Out of total 7268 babies delivered, 116 babies were found to have anomalies. Thirty two of these had musculoskeletal defects. Talipes equinovarus was the commonest anomaly observed followed by polydactyly. The ratio of male babies with musculoskeletal defects to female babies was found to be 1.28:1.The malformed babies were mainly born to term mothers (77.6%), who were mostly unbooked (62.5%) and belonged to lower or middle class. But no significant relationship could be established between these factors and defects. Most mothers were in the age group of 20-35 years and there was no history of drug

  5. Early Rockets

    2004-04-15

    During the 19th century, rocket enthusiasts and inventors began to appear in almost every country. Some people thought these early rocket pioneers were geniuses, and others thought they were crazy. Claude Ruggieri, an Italian living in Paris, apparently rocketed small animals into space as early as 1806. The payloads were recovered by parachute. As depicted here by artist Larry Toschik, French authorities were not always impressed with rocket research. They halted Ruggieri's plans to launch a small boy using a rocket cluster. (Reproduced from a drawing by Larry Toschik and presented here courtesy of the artist and Motorola Inc.)

  6. Sequence stratigraphy, tectonics and hydrocarbon trap geometries of Middle Tertiary strata in the southern San Joaquin Basin, California

    SciT

    Phillips, S.; Hewlett, J.S.; Bazeley, W.J.M.

    1996-01-01

    Tectonic evolution of the southern San Joaquin basin exerted a fundamental control on Cenozoic sequence boundary development, reservoir, source and seal facies distribution, and hydrocarbon trap development. Spatial and temporal variations in Tertiary sequence architecture across the basin reflect differences in eastside versus westside basin-margin geometries and deformation histories. Deposition of Tertiary sequences initiated in a forearc basin setting, bounded on the east by a ramp-margin adjacent to the eroded Sierran arc complex and on the west by the imbricated accretionary wedge of the Coast Ranges thrust. The major stages of Cenozoic basin evolution are: (1) Episodic compressional folding andmore » thrusting associated with oblique convergence of the Farallon and North American plates (Late Cretaceous to Oligocene), (2) localized folding and onset of basin subsidence related to Pacific Plate reorganization, microplate formation and rotation (Oligocene to Early Miocene), (3) transtensional faulting, folding basin subsidence associated with initiation of the San Andreas transform and continued microplate rotation (Micocene to Pliocene), and (4) compressional folding, extensional and strike- slip faulting related to evolution of the Pacific-North American transform boundary (Plio- Pleistocene). Complex stratigraphic relationships within Eocene to Middle Miocene rocks provide examples of tectonic influences on sequence architecture. These include development of: (1) Tectonically enhanced sequence boundaries (Early Eocene base Domengine unconformity) and local mid-sequence angular unconformities, (2) westside-derived syntectonic [open quotes]lowstand[close quotes] systems (Yokut/Turitella Silt wedge and Leda Sand/Cymric/Salt Creek wedge), (3) regional seals associated with subsidence-related transgressions (Round Mountain Silt), and (4) combination traps formed by structural inversion of distal lowstand delta reservoirs (e.g. Coalinga East Extension field).« less

  7. Sequence stratigraphy, tectonics and hydrocarbon trap geometries of Middle Tertiary strata in the southern San Joaquin Basin, California

    SciT

    Phillips, S.; Hewlett, J.S.; Bazeley, W.J.M.

    1996-12-31

    Tectonic evolution of the southern San Joaquin basin exerted a fundamental control on Cenozoic sequence boundary development, reservoir, source and seal facies distribution, and hydrocarbon trap development. Spatial and temporal variations in Tertiary sequence architecture across the basin reflect differences in eastside versus westside basin-margin geometries and deformation histories. Deposition of Tertiary sequences initiated in a forearc basin setting, bounded on the east by a ramp-margin adjacent to the eroded Sierran arc complex and on the west by the imbricated accretionary wedge of the Coast Ranges thrust. The major stages of Cenozoic basin evolution are: (1) Episodic compressional folding andmore » thrusting associated with oblique convergence of the Farallon and North American plates (Late Cretaceous to Oligocene), (2) localized folding and onset of basin subsidence related to Pacific Plate reorganization, microplate formation and rotation (Oligocene to Early Miocene), (3) transtensional faulting, folding basin subsidence associated with initiation of the San Andreas transform and continued microplate rotation (Micocene to Pliocene), and (4) compressional folding, extensional and strike- slip faulting related to evolution of the Pacific-North American transform boundary (Plio- Pleistocene). Complex stratigraphic relationships within Eocene to Middle Miocene rocks provide examples of tectonic influences on sequence architecture. These include development of: (1) Tectonically enhanced sequence boundaries (Early Eocene base Domengine unconformity) and local mid-sequence angular unconformities, (2) westside-derived syntectonic {open_quotes}lowstand{close_quotes} systems (Yokut/Turitella Silt wedge and Leda Sand/Cymric/Salt Creek wedge), (3) regional seals associated with subsidence-related transgressions (Round Mountain Silt), and (4) combination traps formed by structural inversion of distal lowstand delta reservoirs (e.g. Coalinga East Extension field).« less

  8. Is Tertiary Education Expansion Observable in Private Returns to Education? (Evidence for Middle and Eastern European Countries)

    ERIC Educational Resources Information Center

    Štefánik, Miroslav; Horvát, Peter

    2015-01-01

    This article provides evidence about differences in the recent tertiary education expansion in Austria, Germany, the Czech Republic, Poland and Slovakia. Focusing on these differences, we have examined private returns to tertiary education acquired before and after the tertiary education expansion. We compare these returns as follows: Austria with…

  9. Narratives from Aotearoa New Zealand: Building Communities in Early Childhood through the Visual Arts

    ERIC Educational Resources Information Center

    Fuemana-Foa'i, Lisa; Pohio, Lesley; Terreni, Lisa

    2009-01-01

    This article reflects the voices of the authors who are three early childhood tertiary educators and who have presented at the Aotearoa New Zealand Association of Arts Educators Conference held in Wellington in July 2007. The authors revealed many common threads that interwove throughout their individual presentations and made visible an emerging…

  10. Developing Identity and Agency as an Early Career Academic: Lessons from Alice

    ERIC Educational Resources Information Center

    Monk, Sue; McKay, Loraine

    2017-01-01

    This paper draws on Lewis Carroll's character of Alice as a metaphor for interrogating identity construction and agency amongst early career academics, a process which can seem like Alice's pursuit of the White Rabbit in a strange land. Keeping in mind the effects of neoliberalism on the tertiary sector, we recognise the centrality of personal…

  11. An overview of the Tertiary geology and hydrogeology of the northern part of the Arabian Gulf region with special reference to Kuwait

    NASA Astrophysics Data System (ADS)

    Mukhopadhyay, A.; Al-Sulaimi, J.; Al-Awadi, E.; Al-Ruwaih, F.

    1996-06-01

    Tertiary sediments constitute the main source of usable groundwater in Kuwait. Tectonics, depositional environment, lithology and the hydrogeology of these sediments have been reviewed on a regional scale, with special reference to Kuwait. The review showed that Kuwait was situated at the boundary of the stable shelf towards southwest and the unstable shelf towards northeast throughout the Tertiary period. The Tertiary sedimentation started in this area with a marine transgression in the Palaeocene. Shallow marine to sabkha conditions prevailed in the area until the end of the Eocene; a carbonate-evaporite sequence (Umm Er-Radhuma, Rus and Dammam Formation) was deposited during this period. The sea regressed at the end of Eocene, and a widespread unconformity, causing the absence of Oligocene deposits over most of the area, marked the event. The karstification of the Dammam Limestone Formation, that provides localized easier pathways for ground water, took place during this period. The deposition of the clastic sediments of the Kuwait Group and its equivalents on the stable shelf, under mostly continental conditions, started in the early Miocene. The Tertiary aquifers of the area are recharged by occasional rainstorms in the outcrops of Saudi Arabia and Iraq. The water flows towards the north and east in the direction of the regional dip and discharges along the present-day coast of the Gulf. The water quality deteriorates in the same direction, being more mineralized as it flows through the aquifers. The aquifers are presently being exploited at a comparatively high rate. Since the aquifers extend beyond the political boundaries, cooperation among the countries of the region is recommended to ensure the optimum utilization of the scarce water resources of this desert environment.

  12. Stratigraphy and characteristic mollusks of the Pamunkey Group (lower Tertiary) and the Old Church Formation of the Chesapeake Group; Virginia Coastal Plain

    Ward, Lauck W.

    1985-01-01

    Along the Pamunkey River and its tributaries can be found a very complete, well-preserved, Tertiary stratigraphic record that reflects the sea-level changes as well as the local tectonic history of the central Virginia Coastal Plain. Using this record, I have described the lower Tertiary units and proposed a sequential model for their occurrence. Sediments examined in this study range in age from early Paleocene to latest Oligocene or earliest Miocene. Upper Tertiary units are described where they occur in the same sections with the lower Tertiary beds. The Brightseat Formation (lower Paleocene), Aquia Formation (upper Paleocene), Marlboro Clay (upper Paleocene), Nanjemoy Formation (lower Eocene), Piney Point Formation (middle Eocene) and Old Church Formation (new unit, upper Oligocene and lower Miocene) were studied. The definitions of the Piscataway and Paspotansa Members of the Aquia are amended, and a lectostratotype (principal reference section) is designated for those units as well as the Aquia on the Potomac River just below the mouth of Aquia Creek. A lectostratotype section is also designated for the Nanjemoy and its two members, the Potapaco and the Woodstock. That section is on the Potomac above Popes Creek. Beds assigned to the Piney Point and Old Church Formations, previously known only in the subsurface, crop out extensively on the Pamunkey River. A hypostratotype (reference section) is selected for the Piney Point Formation on the Pamunkey River at Horseshoe. The Old Church Formation (named herein) is included in the Chesapeake Group. Areal extent of the stratigraphic units was determined by correlation of outcropping beds on the Pamunkey, Patuxent, Potomac, Rappahannock, Mattaponi, Chickahominy, and James Rivers supplemented by well data. Comparisons of the onlap histories of the Salisbury, Albemarle, and Charleston Embayments indicate a number of simultaneous transgressive events implying global sea-level rises. More restricted transgressions

  13. Early Rockets

    1950-01-01

    Test firing of a Redstone Missile at Redstone Test Stand in the early 1950's. The Redstone was a high-accuracy, liquid-propelled, surface-to-surface missile developed by the von Braun Team under the management of the U.S. Army. The Redstone was the first major rocket development program in the United States.

  14. Early Math.

    ERIC Educational Resources Information Center

    Van Nuys, Ute Elisabeth

    1986-01-01

    Presents reviews of the following mathematics software designed to teach young children counting, number recognition, visual discrimination, matching, addition, and subtraction skills; Stickybear Numbers, Learning with Leeper, Getting Ready to Read and Add, Counting Parade, Early Games for Young Children, Charlie Brown's 1,2,3's, Let's Go Fishing,…

  15. Early Childhood.

    ERIC Educational Resources Information Center

    Peters, Donald L.; Willis, Sherry L.

    This book summarizes theory and discusses major issues pertaining to child development in the early childhood years. Chapter I provides an introduction to the conceptual framework and major theories of child development. Chapter II deals with motor, sensory, and perceptual development. Chapter III focuses on the cognitive-developmental theory of…

  16. Early Rockets

    2004-04-15

    During the early introduction of rockets to Europe, they were used only as weapons. Enemy troops in India repulsed the British with rockets. Later, in Britain, Sir William Congreve developed a rocket that could fire to about 9,000 feet. The British fired Congreve rockets against the United States in the War of 1812.

  17. Early Rockets

    2004-04-15

    In the 19th Century, experiments in America, Europe, and elsewhere attempted to build postal rockets to deliver mail from one location to another. The idea was more novel than successful. Many stamps used in these early postal rockets have become collector's items.

  18. Formation Mechanism of NDMA from Ranitidine, Trimethylamine, and Other Tertiary Amines during Chloramination: A Computational Study

    PubMed Central

    2015-01-01

    Chloramination of drinking waters has been associated with N-nitrosodimethylamine (NDMA) formation as a disinfection byproduct. NDMA is classified as a probable carcinogen and thus its formation during chloramination has recently become the focus of considerable research interest. In this study, the formation mechanisms of NDMA from ranitidine and trimethylamine (TMA), as models of tertiary amines, during chloramination were investigated by using density functional theory (DFT). A new four-step formation pathway of NDMA was proposed involving nucleophilic substitution by chloramine, oxidation, and dehydration followed by nitrosation. The results suggested that nitrosation reaction is the rate-limiting step and determines the NDMA yield for tertiary amines. When 45 other tertiary amines were examined, the proposed mechanism was found to be more applicable to aromatic tertiary amines, and there may be still some additional factors or pathways that need to be considered for aliphatic tertiary amines. The heterolytic ONN(Me)2–R+ bond dissociation energy to release NDMA and carbocation R+ was found to be a criterion for evaluating the reactivity of aromatic tertiary amines. A structure–activity study indicates that tertiary amines with benzyl, aromatic heterocyclic ring, and diene-substituted methenyl adjacent to the DMA moiety are potentially significant NDMA precursors. The findings of this study are helpful for understanding NDMA formation mechanism and predicting NDMA yield of a precursor. PMID:24968236

  19. Formation mechanism of NDMA from ranitidine, trimethylamine, and other tertiary amines during chloramination: a computational study.

    PubMed

    Liu, Yong Dong; Selbes, Meric; Zeng, Chengchu; Zhong, Rugang; Karanfil, Tanju

    2014-01-01

    Chloramination of drinking waters has been associated with N-nitrosodimethylamine (NDMA) formation as a disinfection byproduct. NDMA is classified as a probable carcinogen and thus its formation during chloramination has recently become the focus of considerable research interest. In this study, the formation mechanisms of NDMA from ranitidine and trimethylamine (TMA), as models of tertiary amines, during chloramination were investigated by using density functional theory (DFT). A new four-step formation pathway of NDMA was proposed involving nucleophilic substitution by chloramine, oxidation, and dehydration followed by nitrosation. The results suggested that nitrosation reaction is the rate-limiting step and determines the NDMA yield for tertiary amines. When 45 other tertiary amines were examined, the proposed mechanism was found to be more applicable to aromatic tertiary amines, and there may be still some additional factors or pathways that need to be considered for aliphatic tertiary amines. The heterolytic ONN(Me)2-R(+) bond dissociation energy to release NDMA and carbocation R(+) was found to be a criterion for evaluating the reactivity of aromatic tertiary amines. A structure-activity study indicates that tertiary amines with benzyl, aromatic heterocyclic ring, and diene-substituted methenyl adjacent to the DMA moiety are potentially significant NDMA precursors. The findings of this study are helpful for understanding NDMA formation mechanism and predicting NDMA yield of a precursor.

  20. Secondary structure encodes a cooperative tertiary folding funnel in the Azoarcus ribozyme

    PubMed Central

    Mustoe, Anthony M.; Al-Hashimi, Hashim M.; Brooks, Charles L.

    2016-01-01

    A requirement for specific RNA folding is that the free-energy landscape discriminate against non-native folds. While tertiary interactions are critical for stabilizing the native fold, they are relatively non-specific, suggesting additional mechanisms contribute to tertiary folding specificity. In this study, we use coarse-grained molecular dynamics simulations to explore how secondary structure shapes the tertiary free-energy landscape of the Azoarcus ribozyme. We show that steric and connectivity constraints posed by secondary structure strongly limit the accessible conformational space of the ribozyme, and that these so-called topological constraints in turn pose strong free-energy penalties on forming different tertiary contacts. Notably, native A-minor and base-triple interactions form with low conformational free energy, while non-native tetraloop/tetraloop–receptor interactions are penalized by high conformational free energies. Topological constraints also give rise to strong cooperativity between distal tertiary interactions, quantitatively matching prior experimental measurements. The specificity of the folding landscape is further enhanced as tertiary contacts place additional constraints on the conformational space, progressively funneling the molecule to the native state. These results indicate that secondary structure assists the ribozyme in navigating the otherwise rugged tertiary folding landscape, and further emphasize topological constraints as a key force in RNA folding. PMID:26481360

  1. Acknowleding attributes that enable the career academic nurse to thrive in the tertiary education sector: A qualitative systematic review.

    PubMed

    Wyllie, Aileen; DiGiacomo, Michelle; Jackson, Debra; Davidson, Patricia; Phillips, Jane

    2016-10-01

    To optimise the career development in early career academic nurses by providing an overview of the attributes necessary for success. Evidence of early prospective career planning is necessary to optimise success in the tertiary sector. This is particularly important for nurse academics given the profession's later entry into academia, the ageing nursing workforce and the continuing global shortage of nurses. A qualitative systematic review. Academic Search Complete, CINAHL, Medline, ERIC, Professional Development Collection and Google Scholar databases were searched; resulting in the inclusion of nine qualitative nurse-only focussed studies published between 2004 and 2014. The studies were critically appraised and the data thematically analysed. Three abilities were identified as important to the early career academic nurse: a willingness to adapt to change, an intention to pursue support and embodying resilience. These abilities give rise to attributes that are recommended as key to successful academic career development for those employed on a continuing academic basis. The capacity to rely on one's own capabilities is becoming seen as increasingly important. It is proposed that recognition of these attributes, their skilful application and monitoring outlined in the review are recommended for a successful career in academia. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

  2. First report of tertiary syphilis presenting as lipoatrophic panniculitis in an immunocompetent patient.

    PubMed

    Drago, Francesco; Ciccarese, Giulia; Tomasini, Carlo F; Calamaro, Paola; Boggio, Maurizio; Rebora, Alfredo; Parodi, Aurora

    2017-03-01

    We describe herein a woman who developed subcutaneous gummas in her trochanteric regions, bilaterally, although she had been treated for syphilis two decades earlier. Evidence of Treponema pallidum latent late infection was the presence of IgG antibodies against T. pallidum and the positive non-treponemal and treponemal tests. Moreover, immunohistochemical staining for T. pallidum detected some spirochetes close to the atrophic adipocytes allowing the diagnosis of lypo-atrophic panniculitis tertiary syphilis. This is the first case of tertiary syphilis presenting as panniculitis in an immunocompetent patient, demonstrating that subcutaneous fat may be another organ infected in tertiary syphilis.

  3. Paving Pathways: shaping the Public Health workforce through tertiary education.

    PubMed

    Bennett, Catherine M; Lilley, Kathleen; Yeatman, Heather; Parker, Elizabeth; Geelhoed, Elizabeth; Hanna, Elizabeth G; Robinson, Priscilla

    2010-01-03

    Public health educational pathways in Australia have traditionally been the province of Universities, with the Master of Public Health (MPH) recognised as the flagship professional entry program. Public health education also occurs within the fellowship training of the Faculty of Public Health Medicine, but within Australia this remains confined to medical graduates. In recent years, however, we have seen a proliferation of undergraduate degrees as well as an increasing public health presence in the Vocational Education and Training (VET) sector.Following the 2007 Australian Federal election, the new Labour government brought with it a refreshing commitment to a more inclusive and strategic style of government. An important example of this was the 2020 visioning process that identified key issues of public health concern, including an acknowledgment that it was unacceptable to allocate less than 2% of the health budget towards disease prevention. This led to the recommendation for the establishment of a national preventive health agency (Australia: the healthiest country by 2020 National Preventative Health Strategy, Prepared by the Preventative Health Taskforce 2009).The focus on disease prevention places a spotlight on the workforce that will be required to deliver the new investment in health prevention, and also on the role of public health education in developing and upskilling the workforce. It is therefore timely to reflect on trends, challenges and opportunities from a tertiary sector perspective. Is it more desirable to focus education efforts on selected lead issues such as the "obesity epidemic", climate change, Indigenous health and so on, or on the underlying theory and skills that build a flexible workforce capable of responding to a range of health challenges? Or should we aspire to both?This paper presents some of the key discussion points from 2008 - 2009 of the Public Health Educational Pathways workshops and working group of the Australian

  4. Ethyl tertiary-butyl ether: a toxicological review.

    PubMed

    McGregor, Douglas

    2007-05-01

    A number of oxygenated compounds (oxygenates) are available for use in gasoline to reduce vehicle exhaust emissions, reduce the aromatic compound content, and avoid the use of organo-lead compounds, while maintaining high octane numbers. Ethyl tertiary-butyl ether (ETBE) is one such compound. The current use of ETBE in gasoline or petrol is modest but increasing, with consequently similar trends in the potential for human exposure. Inhalation is the most likely mode of exposure, with about 30% of inhaled ETBE being retained by the lungs and distributed around the body. Following cessation of exposure, the blood concentration of ETBE falls rapidly, largely as a result of its metabolism to tertiary-butyl alcohol (TBA) and acetaldehyde. TBA may be further metabolized, first to 2-methyl-1,2-propanediol and then to 2-hydroxyisobutyrate, the two dominant metabolites found in urine of volunteers and rats. The rapid oxidation of acetaldehyde suggests that its blood concentration is unlikely to rise above normal as a result of human exposure to sources of ETBE. Single-dose toxicity tests show that ETBE has low toxicity and is essentially nonirritant to eyes and skin; it did not cause sensitization in a maximization test in guinea pigs. Neurological effects have been observed only at very high exposure concentrations. There is evidence for an effect of ETBE on the kidney of rats. Increases in kidney weight were seen in both sexes, but protein droplet accumulation (with alpha(2u)-globulin involvement) and sustained increases in cell proliferation occurred only in males. In liver, centrilobular necrosis was induced in mice, but not rats, after exposure by inhalation, although this lesion was reported in some rats exposed to very high oral doses of ETBE. The proportion of liver cells engaged in S-phase DNA synthesis was increased in mice of both sexes exposed by inhalation. ETBE has no specific effects on reproduction, development, or genetic material. Carcinogenicity studies

  5. Students' Perspectives on Worldwide ``Greening'' of Tertiary Education Curricula

    NASA Astrophysics Data System (ADS)

    Aighewi, Isoken T.; Osaigbovo, Ulamen A.

    2010-11-01

    Several scholars have suggested the introduction of an environmental literacy requirement into the curricula of Non-Environmental Science disciplines in tertiary institutions of the world as a “greening” strategy for fostering global environmental stewardship necessary for enhancing understanding and collaboration in tackling the major environmental risks facing our global village today. However, there is no study on students’ opinion on this issue. This study was therefore initiated to 1) evaluate the opinion of undergraduate students on the introduction of a worldwide environmental literacy into the curricula of Non-Environmental science majors as a graduation requirement; and 2) identify any possible demographic differences in opinions among the student subjects polled. We sought the opinion of 800 undergraduates from African, North American and European universities on the subject and 99% responded. The result showed that a majority (67%) of them supported the worldwide environmental literacy requirement and those already trained were significantly ( P < 0.0001) more likely to support it than those untrained. Students from developing countries were significantly ( P < 0.0001) more likely to support it than those from developed countries; similarly students in the Arts’ disciplines were more likely to support it than Non-Arts’ students as a group. However, no significant differences were observed between students from Francophone versus Anglophone countries; Social Sciences versus Non-Social Sciences majors and between Education versus Non-Education majors. Some similarities were observed between the opinion of university-age students in this study and 15-year old secondary school students from two major international surveys (Research on Science Education-ROSE, and Program for International Student Assessment-PISA) on science education; further studies comparing these two categories of students is suggested. The need for all professionals to be

  6. Fungal Profile of Vulvovaginal Candidiasis in a Tertiary Care Hospital.

    PubMed

    Kalaiarasan, Krishnapriya; Singh, Rakesh; Chaturvedula, Latha

    2017-03-01

    Vulvovaginal Candidiasis (VVC) is a common medical health problem of adult women. It is most commonly caused by Candida albicans . But there is a change in fungal profile. Sabouraud's Dextrose Agar (SDA) is the most common culture medium used where mixed fungal infection may be missed. It can be detected easily by using chromogenic culture medium. To know the fungal profile of vulvovaginal candidiasis using Candida CHROMagar and antifungal susceptibility pattern in patients attending tertiary care hospital. Culture confirmed cases of VVC presented at Department of Obstetrics and Gynaecology of Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India, from July 2015 to December 2015 were included in the cross-sectional study. Two high vaginal swabs were collected and inoculated on SDA and Candida CHROMagar (Hi-Media, Mumbai, India). After overnight incubation the colonies were counted and colour of the colonies were recorded from Candida CHROMagar. Candida spp. were identified by sugar fermentation and assimilation tests and other conventional tests. Antifungal susceptibility tests were performed by the disc diffusion method using fluconazole (25 μg) and voriconazole (1μg) as per the Clinical and Laboratory Standards Institute (CLSI - M44-A2) guidelines. A total of 50 culture confirmed (23.7%) cases were detected from 211 clinically suspected VVC cases. Candida glabrata (45.1%) was the most common isolate, followed by Candida tropicalis (23.5%) , Candida albicans (17.6%) , Candida krusei (9.8%) and Candida parapsilosis (3.9%) . One mixed infection of C. glabrata and C. albicans was identified on Candida CHROMagar. Mixed fungal infection was observed in 2% of positive culture and 0.5% of VVC cases. The antifungal susceptibility testing revealed that 15.7% and 9.8% isolates of Candida spp. were resistant and Susceptible Dose Dependent (S-DD) respectively to fluconazole. The increase resistant against fluconazole was because of

  7. Fault reactivation: The Picuris-Pecos fault system of north-central New Mexico

    NASA Astrophysics Data System (ADS)

    McDonald, David Wilson

    The PPFS is a N-trending fault system extending over 80 km in the Sangre de Cristo Mountains of northern New Mexico. Precambrian basement rocks are offset 37 km in a right-lateral sense; however, this offset includes dextral strike-slip (Precambrian), mostly normal dip-slip (Pennsylvanian), mostly reverse dip-slip (Early Laramide), limited strike-slip (Late Laramide) and mostly normal dip-slip (Cenozoic). The PPFS is broken into at least 3 segments by the NE-trending Embudo fault and by several Laramide age NW-trending tear faults. These segments are (from N to S): the Taos, the Picuris, and the Pecos segments. On the east side of the Picuris segment in the Picuris Mountains, the Oligocene-Miocene age Miranda graben developed and represents a complex extension zone south of the Embudo fault. Regional analysis of remotely sensed data and geologic maps indicate that lineaments subparallel to the trace of the PPFS are longer and less frequent than lineaments that trend orthogonal to the PPFS. Significant cross cutting faults and subtle changes in fault trends in each segment are clear in the lineament data. Detailed mapping in the eastern Picuris Mountains showed that the favorably oriented Picuris segment was not reactivated in the Tertiary development of the Rio Grande rift. Segmentation of the PPFS and post-Laramide annealing of the Picuris segment are interpreted to have resulted in the development of the subparallel La Serna fault. The Picuris segment of the PPFS is offset by several E-ESE trending faults. These faults are Late Cenozoic in age and interpreted to be related to the uplift of the Picuris Mountains and the continuing sinistral motion on the Embudo fault. Differential subsidence within the Miranda graben caused the development of several synthetic and orthogonal faults between the bounding La Serna and Miranda faults. Analysis of over 10,000 outcrop scale brittle structures reveals a strong correlation between faults and fracture systems. The dominant

  8. Early Risers

    ERIC Educational Resources Information Center

    Asquith, Chistina

    2002-01-01

    In this article, the author features Bard High School Early College, the first public school in the country to offer a free, full-time college curriculum--and all the credits that go with it--to high schoolers. In Bard's four-year program, students race through high school requirements in 9th and 10th grades, then take college courses in 11th and…

  9. Seismic-Reflection Technology Defines Potential Vertical Bypass in Hydrogeologic Confinement within Tertiary Carbonates of the Southeastern Florida Platform

    NASA Astrophysics Data System (ADS)

    Cunningham, K. J.; Walker, C.; Westcott, R. L.

    2011-12-01

    Continuous improvements in shallow-focused, high-resolution, marine seismic-reflection technology has provided the opportunity to evaluate geologic structures that breach confining units of the Floridan aquifer system within the southeastern Florida Platform. The Floridan aquifer system is comprised mostly of Tertiary platform carbonates. In southeastern Florida, hydrogeologic confinement is important to sustainable use of the Floridan aquifer system, where the saline lower part is used for injection of wastewater and the brackish upper part is an alternative source of drinking water. Between 2007 and 2011, approximately 275 km of 24- and 48-channel seismic-reflection profiles were acquired in canals of peninsular southeastern Florida, Biscayne Bay, present-day Florida shelf margin, and the deeply submerged Miami Terrace. Vertical to steeply dipping offsets in seismic reflections indicate faults, which range from Eocene to possible early Pliocene age. Most faults are associated with karst collapse structures; however, a few tectonic faults of early Miocene to early Pliocene age are present. The faults may serve as a pathway for vertical groundwater flow across relatively low-permeability carbonate strata that separate zones of regionally extensive high-permeability in the Floridan aquifer system. The faults may collectively produce a regional confinement bypass system. In early 2011, twenty seismic-reflection profiles were acquired near the Key Biscayne submarine sinkhole located on the seafloor of the Miami Terrace. Here the water depth is about 365 m. A steeply dipping (eastward) zone of mostly deteriorated quality of seismic-reflection data underlies the sinkhole. Correlation of coherent seismic reflections within and adjacent to the disturbed zone indicates a series of faults occur within the zone. It is hypothesized that upward movement of groundwater within the zone contributed to development of a hypogenic karst system and the resultant overlying sinkhole

  10. Characteristics and risk factors of preterm births in a tertiary center in Lagos, Nigeria.

    PubMed

    Butali, Azeez; Ezeaka, Chinyere; Ekhaguere, Osayame; Weathers, Nancy; Ladd, Jenna; Fajolu, Iretiola; Esezobor, Christopher; Makwe, Christian; Odusanya, Bukola; Anorlu, Rose; Adeyemo, Wasiu; Iroha, Edna; Egri-Okwaji, Mathias; Adejumo, Prisca; Oyeneyin, Lawal; Abiodun, Moses; Badejoko, Bolaji; Ryckman, Kelli

    2016-01-01

    Preterm birth is a dire complication of pregnancy that poses huge long-term medical and financial burdens for affected children, their families, and the health care system. The aim of the present study was to identify characteristics associated with preterm births at the Lagos University Teaching Hospital (LUTH), Lagos, Nigeria from 2011 to 2013. We obtained Information from 5,561 maternal, fetal/neonatal and obstetric records from the labor ward. We excluded delivery at less than 22 weeks (0.25%), post-term birth at ≥42 weeks gestation (1.3%), and unknown gestation (1.4%). Additionally, we excluded records of multiple births (5.4%) and stillbirths (8.3%) leaving 4,691 records of singleton live-births for analysis. Logistic regression analysis was performed comparing preterm birth (22-36 weeks gestation) to term birth (37-41 weeks gestation). Multiple variable models adjusting for maternal age, parity, fetal position, delivery method and booking status were also evaluated. Multinomial regression was used to identify characteristics associated with preterm birth (PTB) defined as early PTB (22-31 weeks gestation), moderate PTB (32-34 weeks gestation), late PTB (35-36 weeks gestation), compared to term birth (37-41 completed weeks gestation). From our data, 16.8% of the singleton live-birth deliveries were preterm (<37 weeks gestation). Of these, 4.7% were early (22-31 weeks), 4.5% were moderate (32-34 weeks) and 7.7% were late (35-36) PTBs. Older maternal age (≥35 years) [odds ratio (OR) = 1.41], hypertension (OR = 3.44) and rupture of membranes (OR = 4.03) were significantly associated with increased odds of PTB. Women being treated for the prevention of mother-to-child transmission of HIV were at a significantly decreased risk for PTB (OR = 0.70). Sixteen percent of women in this cohort were not registered for antenatal care in LUTH. These non-registered subjects had significantly greater odds of all categories of PTB, including early (odds ratio (OR) = 20

  11. Characteristics and risk factors of preterm births in a tertiary center in Lagos, Nigeria

    PubMed Central

    Butali, Azeez; Ezeaka, Chinyere; Ekhaguere, Osayame; Weathers, Nancy; Ladd, Jenna; Fajolu, Iretiola; Esezobor, Christopher; Makwe, Christian; Odusanya, Bukola; Anorlu, Rose; Adeyemo, Wasiu; Iroha, Edna; Egri-Okwaji, Mathias; Adejumo, Prisca; Oyeneyin, Lawal; Abiodun, Moses; Badejoko, Bolaji; Ryckman, Kelli

    2016-01-01

    early (odds ratio (OR) = 20.8), moderate (OR = 8.68), and late (OR = 2.15). Conclusion PTB and risks for PTB remain high in Nigeria. We recommend that any high risk pregnancy should be referred to a tertiary center for prenatal care in order to significantly reduce adverse birth outcomes such as PTBs. PMID:27583065

  12. An extraterrestrial event at the tertiary-quaternary boundary

    NASA Technical Reports Server (NTRS)

    Peng, H.

    1994-01-01

    During the North Pacific Manganese Nodules Investigation in 1983, we collected a large-diameter core M14 (8 deg. 00.15 N, 176 deg, 10.65 W; 3991-m depth of water). This gravity core is 420 cm long in total. It is composed of calcureous ooze at 0-320 cm and siliceous ooze at 320-420 cm of depth. A great number of microtektites were found at 270-300 cm (average content is 15 microtektites per 100-g sediment). Because abundant microtektites are restricted to a 30-m-thick zone of deep-sea core, we called this zone the microtektite layer. The age of the sedimentary stratum containg microtektites is 2.14-2.30 m.y., corresponding to the Pliocene to Pleistocene Periods as indicated by paleomagnetic and paleontologic analysis. We can give the following two primary conclusions: (1) the core M14 microtektites are products of a major meteorite or asteroid impact 2.14-2.30 m.y. ago; and (2) the age of 2.14-2.30 m.y. is an important geological age; perhaps it is just a correct age for dividing the Tertiary/Quarternary boundary. This result is quite close to previous data.

  13. Electronic polarization stabilizes tertiary structure prediction of HP-36.

    PubMed

    Duan, Li L; Zhu, Tong; Zhang, Qing G; Tang, Bo; Zhang, John Z H

    2014-04-01

    Molecular dynamic (MD) simulations with both implicit and explicit solvent models have been carried out to study the folding dynamics of HP-36 protein. Starting from the extended conformation, the secondary structure of all three helices in HP-36 was formed in about 50 ns and remained stable in the remaining simulation. However, the formation of the tertiary structure was difficult. Although some intermediates were close to the native structure, the overall conformation was not stable. Further analysis revealed that the large structure fluctuation of loop and hydrophobic core regions was devoted mostly to the instability of the structure during MD simulation. The backbone root-mean-square deviation (RMSD) of the loop and hydrophobic core regions showed strong correlation with the backbone RMSD of the whole protein. The free energy landscape indicated that the distribution of main chain torsions in loop and turn regions was far away from the native state. Starting from an intermediate structure extracted from the initial AMBER simulation, HP-36 was found to generally fold to the native state under the dynamically adjusted polarized protein-specific charge (DPPC) simulation, while the peptide did not fold into the native structure when AMBER force filed was used. The two best folded structures were extracted and taken into further simulations in water employing AMBER03 charge and DPPC for 25 ns. Result showed that introducing polarization effect into interacting potential could stabilize the near-native protein structure.

  14. Reverse transport of children from a tertiary pediatric hospital.

    PubMed

    McPherson, Mona L; Jefferson, Larry S; Smith, E O'Brian; Sitler, Garry C; Graf, Jeanine M

    2007-01-01

    The purpose of this study was to determine the epidemiology and resources used and to study the potential savings of pediatric reverse transport patients. A case control study was performed with patients undergoing a reverse or outbound transport from a large, pediatric hospital. Twenty-five children undergoing reverse transport were compared with matched controls. Lengths of stay and costs were compared between the reverse transport and matched control patients. Fifty-two percent of the reverse transport patients returned home, whereas 32% went home for end-of-life care and 16% went to other facilities. The average reverse transport was more than 400 miles and cost $6,064. The reverse transport of these patients did not save pediatric intensive care unit (PICU) days but did result in a shorter hospital stay compared with the matched controls (10 vs. 19 days, P = .03). Decreased utilization of bed days came from less use of intermediate care unit resources. Pediatric patients undergo reverse transports for a variety of reasons, often for end-of-life care. The ability to reverse transport pediatric patients may not save PICU bed days but may offer pediatric tertiary care hospitals a means to provide more intermediate care bed availability.

  15. Epidemic keratoconjunctivitis outbreak at a tertiary referral eye care clinic.

    PubMed

    Montessori, V; Scharf, S; Holland, S; Werker, D H; Roberts, F J; Bryce, E

    1998-08-01

    An outbreak of epidemic keratoconjunctivitis (EKC) occurred at a tertiary referral eye care clinic between late September and mid-November 1995. Before the outbreak, instruments were cleaned with 70% isopropyl alcohol and handwashing between patients was not routine. Infection control measures were implemented when the outbreak was recognized in mid-October. Control measures included triaging suspected cases to a separate waiting area, cohorting cases to a specific examining room, endorsing the use of gloves and handwashing during examinations of patients, and cleaning instruments with a buffered bleach solution. Thirty-six cases were diagnosed before the infection control measures were taken, and 3 cases were seen after the control measures were taken. Also, numerous secondary cases occurred in the community. No additional cases were diagnosed from DEcember to February 25, 1996. Acquisition of the infection was linked to visits to 4 of 20 physicians in the eye clinic with 61% of cases associated with visits to 1 of those 4 physicians. The use of diagnostic lenses applied directly to the eye was associated with infection (odds ratio = 2.83, 95% confidence interval = 0.79 to 10.4), although this did not reach statistical significance. The use of tonometers, ophthalmic solutions, or laser therapy was not associated with infection, and all environmental cultures were negative. This outbreak emphasizes the need for implementation of routine infection control guidelines to prevent nosocomial transmission of epidemic keratoconjunctivitis and stresses the need for appropriate disinfection of instruments.

  16. Tertiary structural propensities reveal fundamental sequence/structure relationships.

    PubMed

    Zheng, Fan; Zhang, Jian; Grigoryan, Gevorg

    2015-05-05

    Extracting useful generalizations from the continually growing Protein Data Bank (PDB) is of central importance. We hypothesize that the PDB contains valuable quantitative information on the level of local tertiary structural motifs (TERMs). We show that by breaking a protein structure into its constituent TERMs, and querying the PDB to characterize the natural ensemble matching each, we can estimate the compatibility of the structure with a given amino acid sequence through a metric we term "structure score." Considering submissions from recent Critical Assessment of Structure Prediction (CASP) experiments, we found a strong correlation (R = 0.69) between structure score and model accuracy, with poorly predicted regions readily identifiable. This performance exceeds that of leading atomistic statistical energy functions. Furthermore, TERM-based analysis of two prototypical multi-state proteins rapidly produced structural insights fully consistent with prior extensive experimental studies. We thus find that TERM-based analysis should have considerable utility for protein structural biology. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Mucormycosis at a tertiary care centre in Gujarat, India.

    PubMed

    Patel, Atul K; Patel, Ketan K; Patel, Kamlesh; Gohel, Swati; Chakrabarti, Arunaloke

    2017-06-01

    The prevalence of mucormycosis is reportedly high in India, although the studies are mainly from north and south India only. We analysed the mucormycosis cases at tertiary care centres of West India. We retrieved the clinical details of all the patients with probable and proven mucormycosis diagnosed at Sterling Hospital and ID clinic at Ahmedabad, Gujarat over the period from 1 January 2013 through 30 April 2015. The data were analysed to determine demography, risk factors, underlying diseases, site of infection and outcome of these patients. A total of 27 patients with the median age of 50 (16-65) years were diagnosed with mucormycosis during the period. Rhino-orbital-cerebral mucormycosis was the most common (51.9%) presentation. Majority (55.6%) of the patients had uncontrolled diabetes with or without ketoacidosis; 25.9% patients had no underlying disease and most of them (85.7%) had cutaneous mucormycosis. In this group, the mortality was 25.9% and an equal percentage of patients were lost to follow up; 14 (51.9%) patients could complete 6 weeks of amphotericin B therapy. All patients who completed antifungal therapy survived except one. Like other parts of India, uncontrolled diabetes was the predominant risk factor for mucormycosis in our group. Patients completing 6 weeks of amphotericin B treatment were likely to survive. © 2017 Blackwell Verlag GmbH.

  18. Inherited tertiary hypothyroidism in Sprague-Dawley rats.

    PubMed

    Stoica, George; Lungu, Gina; Xie, Xueyi; Abbott, Louise C; Stoica, Heidi M; Jaques, John T

    2007-05-07

    Thyroid hormones (THs) are important in the development and maturation of the central nervous system (CNS). The significant actions of THs during CNS development occur at the time when TH levels are lower than those in the mother and the hypothalamic-thyroid (HPT) axis is not fully functional. In the developing rat nervous system, primarily the cerebellum, the first three postnatal weeks represent a period of significant sensitivity to thyroid hormones. This study presents a spontaneous, inherited recessive hypothyroidism in Sprague-Dawley rats with devastating functional consequences to the development of the CNS. The clinical signs develop around 14 day's postnatal (dpn) and are characterized by ataxia, spasticity, weight loss and hypercholesterolemia. The afflicted rats died at 30 days due to severe neurological deficits. The deterioration affects the entire CNS and is characterized by progressive neuronal morphological and biochemical changes, demyelination and astrogliosis. The cerebellum, brain stem, neocortex, hippocampus and adrenal gland medulla appear to be most affected. Thyroid Stimulating Hormone (TSH), T3 and T4 levels were significantly lower in hypothyroid rats than control. Immunohistochemistry and RT-PCR demonstrated a reduction of Thyrotropin Releasing Hormone (TRH) in the hypothalamus of hypothyroid rats. The weight of both thyroid and pituitary glands were significantly less in hypothyroid rats than the corresponding normal littermate controls. Transmission electron microscopy demonstrates consistent postsynaptic dendritic, synaptic and spine alterative changes in the brain of hypothyroid rats. These data suggest that we discovered a tertiary form of inherited hypothyroidism involving the hypothalamus.

  19. Experience of Oesophageal atresia management in a tertiary Bangladeshi hospital.

    PubMed

    Islam, Md Kabirul

    2018-01-16

    Background and aim: This study has been conducted to determine the clinical presentations and surgical outcome of patients with OA admitted in a tertiary level hospital in Bangladesh. A prospective analysis was conducted for 32 patients with confirmed OA between July 2007 and June 2015. Of them surgical correction was done in 25 cases. The other 7, in whom surgery could not be done, were excluded from the study. Of the 25 cases, that had been operated, 15 were full term and 52% were more than 48 hours old. Type-C OA with TOF was the commonest type (96%). 24 cases were operated through Right Thoracotomy. Of them 52% were done by Single Lung (left) ventilation. 'Division of the fistula' with 'end to end anastomosis' was done in all of them. Only 1 patient had a Gastric pull up surgery. Of the 25 cases, 16 survived (64%). In follow up all the patients were found thriving and showed no problem in swallowing. Our study which shows 64% survival is a great achievement for us but not satisfactory in international standard. However, the experience and encouragement that we are gathering, will guide us to achieve better result in near future.

  20. [Secondary and tertiary prevention of allergic asthma in children].

    PubMed

    Rancé, F; Deschildre, A; Bidat, E; Just, J; Couderc, L; Wanin, S; Weiss, L

    2010-12-01

    Asthma is a disease of the lung epithelial barrier, most often associated with allergy in children. Asthma and allergy are two distinct diseases, but the phenotypic expression of asthma depends on atopic status. A better definition of phenotypes of asthma would result in better targeting of prevention and treatment modalities. Secondary prevention aims to prevent the onset of asthma and the acquisition of new sensitizations in sensitized children. Studies concerning allergen avoidance are insufficient to reach a definitive conclusion and antihistamines have not been shown to be effective. The results for specific immunotherapy suggest a benefit to prevent transition from allergic rhinitis to asthma and the onset of new sensitizations. Tertiary prevention aims to reduce symptoms in children with an existing allergic asthma diagnosis. The avoidance of known respiratory allergens will only be effective in combination with management of the whole environment. Specific immunotherapy has a real place, in combination with background therapy. It should be used according to guidelines in appropriately treated patients. Copyright © 2010 SPLF. Published by Elsevier Masson SAS. All rights reserved.

  1. Wildfires and animal extinctions at the Cretaceous/Tertiary boundary

    NASA Astrophysics Data System (ADS)

    Adair, Robert K.

    2010-06-01

    Persuasive models of the ejection of material at high velocities from the Chicxulub asteroid impact marking the Cretaceous/Tertiary boundary have led to the conclusion that upon return, that material, heated in passage through the upper atmosphere, generated a high level of infrared energy density over the Earth's surface. That radiant energy has been considered to be a direct source of universal wildfires, which were presumed to be a major cause of plant and animal species extinctions. The extinction of many animal species, especially the dinosaurs, has also been attributed to the immediate lethal effects of the radiation. I find that the absorption of the radiation by the atmosphere, by cloud formations, and by ejecta drifting in the lower atmosphere reduced the radiation at the surface to a level that cannot be expected to have generated universal fires. Although the reduced radiation will have likely caused severe injuries to many animals, such insults alone seem unlikely to have generated the overall species extinctions that have been deduced.

  2. The debate over the Cretaceous-Tertiary boundary

    NASA Technical Reports Server (NTRS)

    Alvarez, W.; Asaro, F.; Alvarez, L. W.; Michel, H. V.

    1988-01-01

    Large-body impact on the Earth is a rare but indisputable geologic process. The impact rate is approximately known from objects discovered in Earth-crossing orbits and from the statistics of craters on the Earth's surface. Tektite and microtektite strewn fields constitute unmistakable ejecta deposits that can be due only to large-body impacts. The Cretaceous-Tertiary (K-T) boundary coincides with an unusually severe biological trauma, and this stratigraphic horizon is marked on a worldwide basis by anomalous concentrations of noble metals in chondritic proportions, mineral spherules with relict quench-crystallization textures, and mineral and rock grains showing shock deformation. These features are precisely compatible with an impact origin. Although only impact explains all the types of K-T boundary evidence, the story may not be as simple as once thought. The original hypothesis envisioned one large impact, triggering one great extinction. Newer evidence hints at various complications. Different challenges are faced by the occupants of each apex of a three-cornered argument over the K-T event. Proponents of a non-impact explanation must show that the evidence fits their preferred model better than it fits the impact scenario. Proponents of the single impact-single extinction view must explain away the complications. Proponents of a more complex impact crisis must develop a reasonable scenario which honors the new evidence.

  3. Recognising and Managing Refractory Coeliac Disease: A Tertiary Centre Experience

    PubMed Central

    Nasr, Ikram; Nasr, Iman; Beyers, Carl; Chang, Fuju; Donnelly, Suzanne; Ciclitira, Paul J.

    2015-01-01

    Refractory coeliac disease (RCD) is a rare complication of coeliac disease (CD) and involves malabsorption and villous atrophy despite adherence to a strict gluten-free diet (GFD) for at least 12 months in the absence of another cause. RCD is classified based on the T-cells in the intra-epithelial lymphocyte (IEL) morphology into type 1 with normal IEL and type 2 with aberrant IEL (clonal) by PCR (polymerase chain reaction) for T cell receptors (TCR) at the β/γ loci. RCD type 1 is managed with strict nutritional and pharmacological management. RCD type 2 can be complicated by ulcerative jejunitis or enteropathy associated lymphoma (EATL), the latter having a five-year mortality of 50%. Management options for RCD type 2 and response to treatment differs across centres and there have been debates over the best treatment option. Treatment options that have been used include azathioprine and steroids, methotrexate, cyclosporine, campath (an anti CD-52 monoclonal antibody), and cladribine or fluadribine with or without autologous stem cell transplantation. We present a tertiary centre’s experience in the treatment of RCD type 2 where treatment with prednisolone and azathioprine was used, and our results show good response with histological recovery in 56.6% of treated individuals. PMID:26633478

  4. Recognising and Managing Refractory Coeliac Disease: A Tertiary Centre Experience.

    PubMed

    Nasr, Ikram; Nasr, Iman; Beyers, Carl; Chang, Fuju; Donnelly, Suzanne; Ciclitira, Paul J

    2015-12-01

    Refractory coeliac disease (RCD) is a rare complication of coeliac disease (CD) and involves malabsorption and villous atrophy despite adherence to a strict gluten-free diet (GFD) for at least 12 months in the absence of another cause. RCD is classified based on the T-cells in the intra-epithelial lymphocyte (IEL) morphology into type 1 with normal IEL and type 2 with aberrant IEL (clonal) by PCR (polymerase chain reaction) for T cell receptors (TCR) at the β/γ loci. RCD type 1 is managed with strict nutritional and pharmacological management. RCD type 2 can be complicated by ulcerative jejunitis or enteropathy associated lymphoma (EATL), the latter having a five-year mortality of 50%. Management options for RCD type 2 and response to treatment differs across centres and there have been debates over the best treatment option. Treatment options that have been used include azathioprine and steroids, methotrexate, cyclosporine, campath (an anti CD-52 monoclonal antibody), and cladribine or fluadribine with or without autologous stem cell transplantation. We present a tertiary centre's experience in the treatment of RCD type 2 where treatment with prednisolone and azathioprine was used, and our results show good response with histological recovery in 56.6% of treated individuals.

  5. Intermittent Demand Forecasting in a Tertiary Pediatric Intensive Care Unit.

    PubMed

    Cheng, Chen-Yang; Chiang, Kuo-Liang; Chen, Meng-Yin

    2016-10-01

    Forecasts of the demand for medical supplies both directly and indirectly affect the operating costs and the quality of the care provided by health care institutions. Specifically, overestimating demand induces an inventory surplus, whereas underestimating demand possibly compromises patient safety. Uncertainty in forecasting the consumption of medical supplies generates intermittent demand events. The intermittent demand patterns for medical supplies are generally classified as lumpy, erratic, smooth, and slow-moving demand. This study was conducted with the purpose of advancing a tertiary pediatric intensive care unit's efforts to achieve a high level of accuracy in its forecasting of the demand for medical supplies. On this point, several demand forecasting methods were compared in terms of the forecast accuracy of each. The results confirm that applying Croston's method combined with a single exponential smoothing method yields the most accurate results for forecasting lumpy, erratic, and slow-moving demand, whereas the Simple Moving Average (SMA) method is the most suitable for forecasting smooth demand. In addition, when the classification of demand consumption patterns were combined with the demand forecasting models, the forecasting errors were minimized, indicating that this classification framework can play a role in improving patient safety and reducing inventory management costs in health care institutions.

  6. Distinguishing between tertiary and secondary facilities: a case study of cardiac diagnostic-related groups (DRGs).

    PubMed

    Rouse, Paul; Arulambalam, Ajit; Correa, Ralph; Ullman, Cornelia

    2010-05-14

    To develop a classification of tertiary cardiac DRGs in order to investigate differences in tertiary/secondary product mix across New Zealand district health boards (DHBs). 67 DRGs from 85,442 cardiac cases were analysed using cost weights and patient comorbidity complexity levels, which were used as a proxy for complexity. The research found high variability of severity within some DRGs. 5 DHBs are the main providers of 27 DRGs which are high cost and identified as tertiary by several ADHB clinicians; the same 5 DHBs have on average higher severity by DRG than the other DHBs. NZ tertiary hospitals have a product mix of DRGs with higher complexity than secondary hospitals. Funding based on case weights needs to recognise the additional resource requirements for this higher complexity.

  7. [Decomposition model of energy-related carbon emissions in tertiary industry for China].

    PubMed

    Lu, Yuan-Qing; Shi, Jun

    2012-07-01

    Tertiary industry has been developed in recent years. And it is very important to find the factors influenced the energy-related carbon emissions in tertiary industry. A decomposition model of energy-related carbon emissions for China is set up by adopting logarithmic mean weight Divisia method based on the identity of carbon emissions. The model is adopted to analyze the influence of energy structure, energy efficiency, tertiary industry structure and economic output to energy-related carbon emissions in China from 2000 to 2009. Results show that the contribution rate of economic output and energy structure to energy-related carbon emissions increases year by year. Either is the contribution rate of energy efficiency or the tertiary industry restraining to energy-related carbon emissions. However, the restrain effect is weakening.

  8. Educational Marketing: A Review and Implications for Supporting Practice in Tertiary Education

    ERIC Educational Resources Information Center

    Stachowski, Christopher Allen

    2011-01-01

    This article reviews the existing educational marketing literature in the leading tertiary educational management journals. A discussion of the implications for supporting practitioners in non-university settings is presented. (Contains 1 table.)

  9. Traditional versus Computer-Based Dissections in Enhancing Learning in a Tertiary Setting: A Student Perspective.

    ERIC Educational Resources Information Center

    Franklin, Sue; Peat, Mary; Lewis, Alison

    2002-01-01

    Describes a study that investigates both the use and usefulness of laboratory dissections and computer-based dissections in a tertiary, first-year human biology course. Explores attitudes toward dissection. (DDR)

  10. Tertiary instability of zonal flows within the Wigner-Moyal formulation of drift turbulence

    NASA Astrophysics Data System (ADS)

    Zhu, Hongxuan; Ruiz, D. E.; Dodin, I. Y.

    2017-10-01

    The stability of zonal flows (ZFs) is analyzed within the generalized-Hasegawa-Mima model. The necessary and sufficient condition for a ZF instability, which is also known as the tertiary instability, is identified. The qualitative physics behind the tertiary instability is explained using the recently developed Wigner-Moyal formulation and the corresponding wave kinetic equation (WKE) in the geometrical-optics (GO) limit. By analyzing the drifton phase space trajectories, we find that the corrections proposed in Ref. to the WKE are critical for capturing the spatial scales characteristic for the tertiary instability. That said, we also find that this instability itself cannot be adequately described within a GO formulation in principle. Using the Wigner-Moyal equations, which capture diffraction, we analytically derive the tertiary-instability growth rate and compare it with numerical simulations. The research was sponsored by the U.S. Department of Energy.

  11. Management of Bile Duct Injury at Various Stages of Presentation: Experience from a Tertiary Care Centre.

    PubMed

    Ibrarullah, Md; Sankar, S; Sreenivasan, K; Gavini, S R K

    2015-04-01

    The clinical presentation, management and outcome of all patients with bile duct injury who presented to our tertiary care centre at various stages after cholecystectomy were analyzed. The patients were categorized into three groups: group A-patients in whom the injury was detected during cholecystectomy, group B-patients who presented within 2 weeks of cholecystectomy and group C-patients who presented after 2 weeks of cholecystectomy. Our team acted as rescue surgeons and performed 'on-table' repair for injuries occurring in another unit or in another hospital. Strasberg classification of bile duct injury was followed. In group A, partial and complete transections were managed by repair over T-tube and high hepaticojejunostomy, respectively. Patients in group B underwent endoscopic retrograde cholangiogram and/or magnetic resonance cholangiogram to evaluate the biliary tree. Those with intact common bile duct underwent endoscopic papillotomy and stenting in addition to drainage of intra-abdominal collection when present. For those with complete transection, early repair was considered if there was no sepsis. In presence of intra-abdominal sepsis an attempt was made to create controlled external biliary fistula. This was followed by hepatico jejunostomy at least after 3 months. Group C patients underwent hepaticojejunostomy at least 6 weeks after the injury. The outcome was graded into three categories: grade A-no clinical symptoms, normal LFT; grade B-no clinical symptoms, mild derangement of LFT or occasional episodes of pain or fever; grade C-pain, cholangitis and abnormal LFT; grade D-surgical revision or dilatation required. Fifty nine patients were included in the study and the distribution was group A-six patients, group B-33 patients and group C-20 patients. In group A, one patient with complete transection of the right hepatic duct (type C) and partial injury to left hepatic duct (LHD) underwent right hepaticojejunostomy and repair of the LHD over

  12. Expansion tunnel performance with and without an electromagnetically opened tertiary diaphragm

    NASA Technical Reports Server (NTRS)

    Miller, C. G.

    1977-01-01

    A study was conducted to examine the effect of synchronization of an electromagnetically opened tertiary diaphragm with flow arrival at the diaphragm on the pitot pressure measured at the test section of an expansion tunnel. The effect of tertiary diaphragm pressure ratio (ratio of initial nozzle pressure to quiescent acceleration section pressure) on the pitot pressure time history is also determined. The inadequacy of a pressure transducer protection arrangement used in previous expansion tube and expansion tunnel tests was revealed.

  13. Pacing in congenital heart disease - A four-decade experience in a single tertiary centre.

    PubMed

    Midha, Disha; Chen, Zhong; Jones, David G; Williams, Howell J; Lascelles, Karen; Jarman, Julian; Clague, Jonathan; Till, Janice; Dimopoulos, Konstatinos; Babu-Narayan, Sonya V; Markides, Vias; Gatzoulis, Michael A; Wong, Tom

    2017-08-15

    The increased risk of brady- and tachy-arrhythmias in the congenital heart disease (CHD) population means that cardiac rhythm management devices are often required at an early age and expose patients to device-related complications. The present study drew upon four decades of experience at a tertiary adult congenital heart disease ACHD center and aimed to investigate the indication for cardiac implantable electronic devices (CIEDs) and predictors of late device-related complication requiring re-intervention. A retrospective review of pacing records of ACHD patients over forty years was carried out. The primary outcome measure was device related complication requiring re-intervention. Between 1970 and 2009, 238 structural CHD patients who received CIEDs with follow-up data were identified (structural group). As a comparator group, 98 patients with congenital conduction disease or long QT syndrome with a structurally normal heart (electrical group) were included in the study. During a mean follow-up of 9.6±8.5years, 72 (21%) patients (44 structural group, 28 electrical group) required ≥1 re-intervention due to device related complications. Multivariate analysis showed that age at the time of device implant was an independent predictor of late device-related complications (HR 0.77, 95% CI 0.60-0.98, p=0.04). Sub-analysis of the structural group showed that ACHD complexity (Bethesda guideline) was the only predictor late device-related complication in the structural group (HR 2.96, 95% CI: 1.67-5.26, p<0.01). Increasing age at device implant was inversely associated with late device-related complications. ACHD patients with complex anatomy are at increased risk of device-related complications at mid and long-term follow-up. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Presentations and Outcome of Thyroiditis from a Tertiary Care Hospital of Karachi.

    PubMed

    Mahar, Saeed Ahmed; Shahid, Muhammad; Sarfaraz, Aqiba; Shaikh, Zuhaib-u-Ddin; Shaikh, Shiraz; Shahid, Nadia

    2015-10-01

    To assess the clinical presentations and short-term outcomes of patients with thyroiditis presenting to a tertiary care hospital in Karachi, Pakistan. Case series. Department of Endocrinology, Liaquat National Hospital, Karachi, from June 2014 to February 2015. Patients between 18 and 70 years of age with acute onset of thyroiditis confirmed on thyroid scan or clinical judgment presenting to the outpatient services were included in the study. Pregnant females, psychiatric patients and patients having other chronic illnesses were excluded from the study. A total of 26 patients with thyroiditis attended the endocrine clinic. Mean age of patients was 41.2 ± 11.12 years. There were 18 (69.2%) females. Clinical presentations were fever (65.4%), tender neck (23.1%), goiter (19.2%), localized tenderness in neck and palpable lymph nodes (26.9%). Major symptoms reported were: sore throat (69.2%), weight loss (38.5%), upper respiratory tract infection, thyroid pain, tremor, sweating and fever of unknown origin in 26.9% cases. All the patients had raised Erythrocyte Sedimentation Rate (ESR). Low Thyroid Stimulating Hormone (TSH) < 0.4 mlU/L was seen in 88.5% and 57.7% had raised Free T4 > 1.8 ng/dL. Complete recovery was seen in 88.5% patients while 11.5% had early hypothyroidism. Fever and sore throat were the main presenting features of thyroiditis patients. ESR was raised in all patients. A majority of patients had complete recovery with appropriate management; however, few cases developed hypothyroidism.

  15. Second Malignant Neoplasms in Childhood Cancer Survivors Treated in a Tertiary Paediatric Oncology Centre.

    PubMed

    Lim, Jia Wei; Yeap, Frances Sh; Chan, Yiong Huak; Yeoh, Allen Ej; Quah, Thuan Chong; Tan, Poh Lin

    2017-01-01

    Introduction : One of the most feared complications of childhood cancer treatment is second malignant neoplasms (SMNs). This study evaluates the incidence, risk factors and outcomes of SMNs in a tertiary paediatric oncology centre in Singapore. Materials and Methods : A retrospective review was conducted on patients diagnosed with childhood cancer under age 21 and treated at the National University Hospital, Singapore, from January 1990 to 15 April 2012. Case records of patients with SMNs were reviewed. Results : We identified 1124 cases of childhood cancers with a median follow-up of 3.49 (0 to 24.06) years. The most common primary malignancies were leukaemia (47.1%), central nervous system tumours (11.7%) and lymphoma (9.8%). Fifteen cases developed SMNs, most commonly acute myeloid leukaemia/myelodysplastic syndrome (n = 7). Median interval between the first and second malignancy was 3.41 (0.24 to 18.30) years. Overall 20-year cumulative incidence of SMNs was 5.3% (95% CI, 0.2% to 10.4%). The 15-year cumulative incidence of SMNs following acute lymphoblastic leukaemia was 4.4% (95% CI, 0% to 8.9%), significantly lower than the risk after osteosarcoma of 14.2% (95% CI, 0.7% to 27.7%) within 5 years ( P <0.0005). Overall 5-year survival for SMNs was lower than that of primary malignancies. Conclusion : This study identified factors explaining the epidemiology of SMNs described, and found topoisomerase II inhibitor use to be a likely risk factor in our cohort. Modifications have already been made to our existing therapeutic protocols in osteosarcoma treatment. We also recognised the importance of other risk management strategies, including regular long-term surveillance and early intervention for detected SMNs, to improve outcomes of high risk patients.

  16. Fast Track Extubation In Adult Patients On Pump Open Heart Surgery At A Tertiary Care Hospital.

    PubMed

    Akhtar, Mohammad Irfan; Sharif, Hasanat; Hamid, Mohammad; Samad, Khalid; Khan, Fazal Hameed

    2016-01-01

    Fast-track cardiac surgery programs have been established as the standard of cardiac surgical care. Studies have shown that early extubation in elective cardiac surgery patients, including coronary and non-coronary open-heart surgery patients does not increase perioperative morbidity and mortality. The objective of this observational study was to determine the success and failure profile of fast track extubation (FTE) practice in adult open-heart surgical patients. The study was conducted at cardiac operating room and Cardiac Intensive Care Unit (CICU) of a tertiary care hospital for a period of nine months, i.e., from Oct 2014 to June-2015. All on pump elective adult cardiac surgery patients including isolated CABG, isolated Valve replacements, combined procedures and aortic root replacements were enrolled in the study. Standardized anesthetic technique was adopted. Surgical and bypass techniques were tailored according to the procedure. Success of Fast track extubation was defined as extubation within 6 hours of arrival in CICU. A total of 290 patients were recruited. The average age of the patients was 56.3±10.5 years. There were 77.6% male and 22.4% female patients. Overall success rate was 51.9% and failure rate was 48.1%. The peri-operative renal insufficiency, cross clamp time and CICU stay (hours) were significantly lower in success group. Re-intubation rate was 0.74%. The perioperative parameters were significantly better in success group and the safety was also demonstrated in the patients who were fast tracked successfully. To implement the practice in its full capacity and benefit, a fast track protocol needs to be devised to standardize the current practices and to disseminate the strategy among junior anaesthesiologists, perfusionists and nursing staff.

  17. Obligation towards medical errors disclosure at a tertiary care hospital in Dubai, UAE

    PubMed Central

    Zaghloul, Ashraf Ahmad; Rahman, Syed Azizur; Abou El-Enein, Nagwa Younes

    2016-01-01

    OBJECTIVE: The study aimed to identify healthcare providers’ obligation towards medical errors disclosure as well as to study the association between the severity of the medical error and the intention to disclose the error to the patients and their families. DESIGN: A cross-sectional study design was followed to identify the magnitude of disclosure among healthcare providers in different departments at a randomly selected tertiary care hospital in Dubai. SETTING AND PARTICIPANTS: The total sample size accounted for 106 respondents. Data were collected using a questionnaire composed of two sections namely; demographic variables of the respondents and a section which included variables relevant to medical error disclosure. RESULTS: Statistical analysis yielded significant association between the obligation to disclose medical errors with male healthcare providers (X2 = 5.1), and being a physician (X2 = 19.3). Obligation towards medical errors disclosure was significantly associated with those healthcare providers who had not committed any medical errors during the past year (X2 = 9.8), and any type of medical error regardless the cause, extent of harm (X2 = 8.7). Variables included in the binary logistic regression model were; status (Exp β (Physician) = 0.39, 95% CI 0.16–0.97), gender (Exp β (Male) = 4.81, 95% CI 1.84–12.54), and medical errors during the last year (Exp β (None) = 2.11, 95% CI 0.6–2.3). CONCLUSION: Education and training of physicians about disclosure conversations needs to start as early as medical school. Like the training in other competencies required of physicians, education in communicating about medical errors could help reduce physicians’ apprehension and make them more comfortable with disclosure conversations. PMID:27567766

  18. Afro-Asian cockroach from Chiapas amber and the lost Tertiary American entomofauna

    NASA Astrophysics Data System (ADS)

    Vršanský, Peter; Cifuentes-Ruiz, Paulina; Vidlička, Ľubomír; Čiampor, Fedor; Vega, Francisco J.

    2011-10-01

    Cockroach genera with synanthropic species (Blattella, Ectobius, Supella, Periplaneta, Diploptera and ?Blatta), as well as other insects such as honeybees, although natively limited to certain continents nowadays, had circumtropic distribution in the past. The ease of their reintroduction into their former range suggests a post-Early Miocene environmental stress which led to the extinction of cosmopolitan Tertiary entomofauna in the Americas, whilst in Eurasia, Africa and Australia this fauna survived. This phenomenon is demonstrated here on a low diversity (10 spp.) living cockroach genus Supella, which is peculiar for the circumtropical synanthropic brownbanded cockroach S. longipalpa and also for its exclusively free-living cavicolous species restricted to Africa. S. (Nemosupella) miocenica sp. nov. from the Miocene amber of Chiapas in Mexico is a sister species to the living S. mirabilis from the Lower Guinea forests and adjacent savannas. The difference is restricted to the shape of the central macula on the pronotum, and size, which may indicate the around-Miocene origin of the living, extremely polymorphic Supella species and possibly also the isochronic invasion into the Americas. The species also has a number of characteristics of the Asian (and possibly also Australian) uniform genus Allacta (falling within the generic variability of Supella) suggesting Supella is a direct ancestor of the former. The present species is the first significant evidence for incomplete hiati between well defined cockroach genera — a result of the extensive fossil record of the group. The reported specimen is covered by a mycelium of a parasitic fungus Cordyceps or Entomophthora.

  19. Benthic foraminifera at the Cretaceous-Tertiary boundary around the Gulf of Mexico

    NASA Astrophysics Data System (ADS)

    Alegret, Laia; Molina, Eustoquio; Thomas, Ellen

    2001-10-01

    Cretaceous-Tertiary (K-T) boundary sections in northeastern Mexico contain marly formations separated by a controversial clastic unit. Benthic foraminifera in seven sections indicate middle and lower bathyal depths of deposition for the marls, with the exception of the upper bathyal northernmost section. Mixed neritic-bathyal faunas were present in the clastic unit, indicating redeposition in the deep basin by mass-wasting processes resulting from the K-T bolide impact in the Gulf of Mexico. Benthic foraminifera in the Mexican sections, and at other deep-sea locations, were not subject to major extinction at the time of impact, but there were temporary changes in assemblage composition. Benthic faunas indicate well- oxygenated bottom waters and mesotrophic conditions during the late Maastrichtian and increased food supply during the latest Maastrichtian. The food supply decreased drastically just after the K-T boundary, possibly because of the collapse of surface productivity. Cretaceous and early Paleogene benthic foraminifera, however, did not exhibit the benthic-pelagic coupling of present-day faunas, as documented by the lack of significant extinction at the K-T collapse of surface productivity. Much of the food supplied to the benthic faunas along this continental margin might have been refractory material transported from land or shallow coastal regions. The decrease in food supply at the K-T boundary might be associated with the processes of mass wasting, which removed surface, food-rich sediment. Benthic faunas show a staggered pattern of faunal recovery in the lowermost Paleogene, consistent with a staged recovery of the vertical organic flux but also with a gradual buildup of organic matter in the sediment.

  20. An assessment of the safe delivery incentive program at a tertiary level hospital in Nepal.

    PubMed

    Baral, G

    2012-05-01

    Maternity incentive program of Nepal known as Safe Delivery Incentive Program (SDIP) was introduced nationwide in 2005 with the intention of increasing utilization of professional care at childbirth. The program provided both childbirth service as well as 'cash' to women giving birth in a health facility in addition to incentives to health provider for each delivery attended, either at home or the facility. Due to a lack of uniformity in its implementation and administrative delays, the program was reformed and even extended to many not-for-profit health institutions in early 2007, and implemented as a 'Safer Mother Program' popularly known as "Aama-Suraksha-Karyakram" since January 2009. This is a system research with observational and analytical components. Plausibility design is selected to evaluate the performance-based funding (PBF) as a system level intervention of maternity care using two instruments: Pay-For-Performance and Conditional-Cash-Transfer. It uses interrupted time-series to control for the natural trend. Research tools used are interviews, the focus group discussions and literature review. Numerical data are presented in simple graphs. While online random number generator was used partly, the purposive sampling was used for qualitative data. There is a gross discrepancy in non-targeted service delivery at the tertiary level health facility. Overflooding of maternity cases has hampered gynecological admission and surgical management delaying subspecialty care and junior physicians' training. With the same number and quality of physical facility and human resource, the additional program has put more strains to service providers and administrators. There should be adequate planning and preparation at all levels of health facilities; implementing a new program should not adversely affect another existing service delivery system. For the optional implementation, hospital organogram should be revised; and physical facilities and the low-risk birthing

  1. Tertiary individual prevention improves mental health in patients with severe occupational hand eczema.

    PubMed

    Breuer, K; John, S M; Finkeldey, F; Boehm, D; Skudlik, C; Wulfhorst, B; Dwinger, C; Werfel, T; Diepgen, T L; Schmid-Ott, G

    2015-09-01

    Occupational hand eczema (OHE) is associated with impaired health-related quality of life (QoL) and mental distress. Interdisciplinary inpatient rehabilitation measures in the framework of tertiary individual prevention (TIP) offered by the German employers' liability insurance associations include dermatological treatment, education and psychological interventions. To investigate the effects of interdisciplinary inpatient rehabilitation in the framework of TIP on mental health in patients with severe OHE and the relationships between recovery of OHE and improvement of mental health and QoL. A total of 122 patients participated in the study. A test battery consisting of the German versions of the Hospital Anxiety and Depression Scale (HADS-D), the Dermatology Life Quality Index (DLQI), the Short Form Health Survey-36 (SF-36) and the Trier Inventory for the Assessment of Chronic Stress (TICS) was applied at the time of admission (T1) and 3 weeks after dismissal (T2). Severity of hand eczema was assessed with the Osnabrueck Hand Eczema Severity Index (OHSI). All parameters improved significantly from T1 to T2. A relationship was established between the improvement of QoL and recovery of OHE, while there was no such relationship between the improvement of mental distress and improvement of OHE. Nonresponders had significantly more cumulative days of sickness at T1. Our data underscore the importance of psychological interventions in addition to dermatological treatment in the framework of prevention measures for OHE. These measures should be applied at an early stage of OHE prior to the occurrence of sick leave. © 2015 European Academy of Dermatology and Venereology.

  2. Tertiary deformation history of southeastern and southwestern Tibet during the Indo-Asian collision

    SciT

    Yin, A.; Harrison, T.M.; Murphy, M.A.

    1999-11-01

    Geologic mapping and geochronological analysis in southwest (Kailas area) and southeast (Zedong area) Tibet reveal two major episodes of Tertiary crustal shortening along the classic Indus-Tsangpo suture in the Yalu River valley. The older event occurred between ca. 30 and 24 Ma during movement along the north-dipping Gangdese thrust. The development of this thrust caused extensive denudation of the Gangdese batholith in its hanging wall and underthrusting of the Xigase forearc strata in its footwall. Examination of timing of major tectonic events in central Asia suggests that the initiation of the Gangdese thrust was approximately coeval with the late Oligocenemore » initiation and development of north-south shortening in the eastern Kunlun Shan of northern Tibet, the Nan Shan at the northeastern end of the Altyn Tagh fault, the western Kunlun Shan at the southwestern end of the Altyn Tagh fault, and finally the Tian Shan (north of the tarim basin). Such regionally synchronous initiation of crustal shortening in and around the plateau may have been related to changes in convergence rate and direction between the Eurasian plate and the Indian and Pacific plates. The younger thrusting event along the Yalu River valley occurred between 19 and 10 Ma along the south-dipping Great Counter thrust system, equivalent to the locally named Renbu-Zedong thrust in southeastern Tibet, the Backthrust system in south-central Tibet, and the South Kailas thrust in southwest Tibet. The coeval development of the Great Counter thrust and the North Himalayan granite-gneiss dome belt is consistent with their development being related to thermal weakening of the north Himalayan and south Tibetan crust, due perhaps to thermal relaxation of an already thickened crust created by the early phase of collision between India and Asia or frictional heating along major thrusts, such as the Main Central thrust, beneath the Himalaya.« less

  3. Perceptions and concerns of women undergoing Pap smear examination in a tertiary care hospital of India.

    PubMed

    Tiwari, A; Kishore, J; Tiwari, A

    2011-01-01

    Cervical cancer is one of the major causes of deaths due to cancer among women in India. Pap smear is one of the best methods to detect early changes in cervix. However, there is lack of data on awareness level of women about Pap smear and various risk factors for cervical cancer. To study the awareness about various risk factors for cervical cancer, health-seeking behavior and hygienic practices among women and to assess the distress experienced by these women before the Pap smear examination. This cross-sectional study was carried out on women coming for a Pap smear examination in a tertiary teaching hospital in New Delhi. A pretested interview schedule was used to get information after obtaining their informed consent. Fifty-seven percent stated that they did not consult a doctor when they noticed the symptoms the first time. Sixty-one percent did not know what a cervical cancer is and a same percentage of women did not know what a Pap smear examination was. Older age group, Muslim and literate women had higher number of abnormal Pap smear results. Women who reported being stressed in their lives had higher number of abnormal smears as compared to women who claimed to lead a stress free life. Poor hygienic practices among these women from urban areas were also associated with abnormal Pap smear results. The study concluded that factors such as poor awareness, shyness, poor hygiene, and old age could be responsible for abnormal Pap smears and this needs special attention in cancer prevention activities of the government.

  4. Population and Colony-Level Determinants of Tertiary Sex Ratio in the Declining Barn Swallow

    PubMed Central

    Saino, Nicola; Romano, Maria; Rubolini, Diego; Caprioli, Manuela; Ambrosini, Roberto; Boncoraglio, Giuseppe; Canova, Luca

    2013-01-01

    Sex ratio of adults (tertiary sex ratio, TSR) is a major feature of animal populations with consequences for their behaviour, genetic structure and viability. Spatial and temporal variation in TSR occurs within species but the mechanisms behind it are poorly understood. In this long-term study of a declining population of a socially monogamous, colonial, migratory bird, the barn swallow (Hirundo rustica), we first analyzed population-level variation in TSR ( = proportion of males) of yearlings at sexual maturation in relation to ecological conditions as gauged by annual survival rate of adults. TSR was male-biased both among yearlings and older individuals, but male bias of yearlings was more pronounced after years with larger decline in adult survival. Thus, male offspring were less susceptible to the adverse ecological conditions that cause increased mortality. Dispersal and settling site decisions can have major consequences on fitness via the effects of local TSR on mating and sperm competition. Breeding barn swallows are highly philopatric while natal dispersal is high and, together with mortality, is the main determinant of colony TSR. We thus also investigated the mechanisms of breeding colony choice by yearlings and found that TSR of new-settlers in a given colony and year was negatively predicted by TSR of returning, early arriving older individuals in that year, but not by overall TSR at the colony in the previous year. This suggests that in our male-biased population new-settler males respond to local TSR upon arrival to choose the sites with larger breeding opportunities. Hence, variation in ecological conditions as reflected by adult survival can shift the TSR of individuals recruiting into a local population, with potentially various demographic consequences. However, breeding site choice based on TSR tends to homogenize TSR at a population level likely by facilitating settling of dispersing males in colonies with less male-biased TSR. PMID

  5. Childhood intussusception: 17-year experience at a tertiary referral centre in Hong Kong.

    PubMed

    Wong, Carol W Y; Chan, Ivy H Y; Chung, Patrick H Y; Lan, Lawrence C L; Lam, Wendy W M; Wong, Kenneth K Y; Tam, Paul K H

    2015-12-01

    To review all paediatric patients with intussusception over the last 17 years. Retrospective case series. A tertiary centre in Hong Kong. Children who presented with intussusception from January 1997 to December 2014 were reviewed. The duration of symptoms, successful treatment modalities, complication rate, and length of hospital stay were studied. A total of 173 children (108 male, 65 female) presented to our hospital with intussusception during the study period. Their median age at presentation was 12.5 months (range, 2 months to 16 years) and the mean duration of symptoms was 2.3 (standard deviation, 1.8) days. Vomiting was the most common symptom (76.3%) followed by abdominal pain (46.2%), per rectal bleeding or red currant jelly stool (40.5%), and a palpable abdominal mass (39.3%). Overall, 160 patients proceeded to pneumatic or hydrostatic reduction, among whom 127 (79.4%) were successful. Three (1.9%) patients had bowel perforation during the procedure. Early recurrence of intussusception occurred in four (3.1%) patients with non-operative reduction. No recurrence was reported in the operative group. The presence of a palpable abdominal mass was a risk factor for operative treatment (relative risk=2.0; 95% confidence interval, 1.8-2.2). Analysis of our results suggested that duration of symptoms did not affect the success rate of non-operative reduction. Non-operative reduction has a high success rate and low complication rate, but the presence of a palpable abdominal mass is a risk factor for failure. Operative intervention should not be delayed in those patients who encounter difficult or doubtful non-operative reduction.

  6. Traumatic penile injuries: Mechanisms and problems of treatment in a tertiary institution in Nigeria.

    PubMed

    Oranusi, C K; Nwofor, Ame

    2014-01-01

    Penile injuries are uncommon. The more severe injuries are often difficult to manage. We report our experience with penile injuries from different causes and treatment options available. We analyzed retrospectively 23 cases of penile injuries presenting to the Urology Unit of a tertiary hospital in the Southeastern part of Nigeria from January 2007 to December 2012. The management for each patient varied depending on the nature and extent of the injury. The mean age of the patients was 28.9 ± 14.4 years (range 3 weeks to 43 years). The mean duration before presentation was 22.7 ± 17.8 h (range 1-168 h). The causes of penile injuries were categorized as follows: Postcircumcision 3 (13.0%), genital mutilation (self-inflicted injury/attacks by assailants) 6 (26.1%), accident 4 (17.4%), penile fracture 8 (34.8%), and gunshot injury 2 (8.6%). Isolated blunt injuries to the corporal tissues as occurs in penile fractures was managed successfully with early exploration and closure of the tunical tear, while injuries to the penile skin was managed with dressing and secondary closure. Severe penile injuries resulting in partial or total phallic loss presented the most challenge to treatment. Traumatic penile injuries are not common. Severe penile injuries could be challenging because of the nature of the injuries, delayed presentation and unavailability of modern technological tools and experience required for the treatment of such severe injuries. Expertise in the use of flaps for a neophallus are still been developed, and penile prosthetic devices are not readily available in our setting.

  7. Textural and mineralogical study of sandstones from the onshore Gulf of Alaska Tertiary Province, southern Alaska

    Winkler, Gary R.; McLean, Hugh; Plafker, George

    1976-01-01

    Petrographic examination of 74 outcrop samples of Paleocene through Pliocene age from the onshore Gulf of Alaska Tertiary Province indicates that sandstones of the province characteristically are texturally immature and mineralogically unstable. Diagenetic alteration of framework grains throughout the stratigraphic sequence has produced widespread zeolite cement or phyllosilicate grain coatings and pseudomatrix. Multiple deformation and deep burial of the older Tertiary sequence--the Orca Group, the shale of Haydon Peak, and the Kulthieth and Tokun Formations--caused extensive alteration and grain interpenetration, resulting in low porosity values. Less intense deformation and intermediate depth of burial of the younger Tertiary sequence--the Katalla, Poul Creek, Redwood, and Yakataga Formations--has resulted in a greater range in textural properties. Most sandstone samples in the younger Tertiary sequence are poorly sorted, tightly packed, and have strongly appressed framework grains, but some are less tightly packed and contain less matrix. Soft and mineralogically unstable framework grains have undergone considerable alteration, reducing pore space even in the youngest rocks. Measurements of porosity, permeability, grain density, and sonic velocity of outcrop samples of the younger Tertiary sequence indicate a modest up-section improvement in sandstone reservoir characteristics. Nonetheless porosity and permeability values typically are below 16 percent and 15 millidarcies respectively and grain densities are consistently high, about 2.7 gm/cc. Low permeability and porosity values, and high grain densities and sonic velocities appear to be typical of most outcrop areas throughout the onshore Gulf of Alaska Tertiary Province.

  8. The Prevalence and Symptoms Characteristic of Functional Constipation Using Rome III Diagnostic Criteria among Tertiary Education Students

    PubMed Central

    2016-01-01

    Background and Aims Functional constipation is very common with heterogeneous symptoms that have substantial impact on patient quality of life as well as medical resources which are rarely reported as life-threatening. The aim of this study is to examine the prevalence and symptoms characteristic of functional constipation (FC) by using Rome III diagnostic criteria among tertiary education students with an intention to introduce treatment in the future. Methods Demographic, socio-economics characteristics and symptoms of FC using the Rome III criteria were sought using a questionnaire administered to Malaysian students in a tertiary education setting. Other data obtained were the general health status, lifestyle factors and anthropometric measurements. Using a simple random sampling method, a total of 1662 students were recruited in the study with a response rate of 95.0%. Sampled data are presented as frequency and percentage and stratified accordingly into categories for Chi-square analysis. Results The prevalence of functional constipation among the students was 16.2%, with a significantly higher prevalence among women (17.4%) than men (12.5%). Hard or lumpy stool, incomplete evacuation, anorectal obstruction and straining were reported as the commonest symptoms experienced. Type 3 was the most frequent stool consistency experienced among the constipated individuals (35.2%). Only 4.4% of individuals reported having less than three defecations per week. Using univariable analysis, FC was significantly associated with sex (odds ratio: 1.48, 95% CI: 1.06–2.06) and age group (odds ratio: 1.34, 95% CI: 1.01–1.79) with P value < 0.05 significance level. In multivariate logistic regression analysis, only sex was found significantly associated with FC (adjusted odds ratio: 1.53, 95% CI: 1.08–2.17, P < 0.05). Conclusions Based on the prevalence rate, constipation is a common problem among tertiary education students (16.2%), with significantly more prevalence among

  9. A tectonic model for the Tertiary evolution of strike slip faults and rift basins in SE Asia

    NASA Astrophysics Data System (ADS)

    Morley, C. K.

    2002-04-01

    Models for the Tertiary evolution of SE Asia fall into two main types: a pure escape tectonics model with no proto-South China Sea, and subduction of proto-South China Sea oceanic crust beneath Borneo. A related problem is which, if any, of the main strike-slip faults (Mae Ping, Three Pagodas and Aliao Shan-Red River (ASRR)) cross Sundaland to the NW Borneo margin to facilitate continental extrusion? Recent results investigating strike-slip faults, rift basins, and metamorphic core complexes are reviewed and a revised tectonic model for SE Asia proposed. Key points of the new model include: (1) The ASRR shear zone was mainly active in the Eocene-Oligocene in order to link with extension in the South China Sea. The ASRR was less active during the Miocene (tens of kilometres of sinistral displacement), with minor amounts of South China Sea spreading centre extension transferred to the ASRR shear zone. (2) At least three important regions of metamorphic core complex development affected Indochina from the Oligocene-Miocene (Mogok gneiss belt; Doi Inthanon and Doi Suthep; around the ASRR shear zone). Hence, Paleogene crustal thickening, buoyancy-driven crustal collapse, and lower crustal flow are important elements of the Tertiary evolution of Indochina. (3) Subduction of a proto-South China Sea oceanic crust during the Eocene-Early Miocene is necessary to explain the geological evolution of NW Borneo and must be built into any model for the region. (4) The Eocene-Oligocene collision of NE India with Burma activated extrusion tectonics along the Three Pagodas, Mae Ping, Ranong and Klong Marui faults and right lateral motion along the Sumatran subduction zone. (5) The only strike-slip fault link to the NW Borneo margin occurred along the trend of the ASRR fault system, which passes along strike into a right lateral transform system including the Baram line.

  10. Fully digital data processing during cardiovascular implantable electronic device follow-up in a high-volume tertiary center.

    PubMed

    Staudacher, Ingo; Nalpathamkalam, Asha Roy; Uhlmann, Lorenz; Illg, Claudius; Seehausen, Sebastian; Akhavanpoor, Mohammadreza; Buchauer, Anke; Geis, Nicolas; Lugenbiel, Patrick; Schweizer, Patrick A; Xynogalos, Panagiotis; Zylla, Maura M; Scholz, Eberhard; Zitron, Edgar; Katus, Hugo A; Thomas, Dierk

    2017-10-11

    Increasing numbers of patients with cardiovascular implantable electronic devices (CIEDs) and limited follow-up capacities highlight unmet challenges in clinical electrophysiology. Integrated software (MediConnect ® ) enabling fully digital processing of device interrogation data has been commercially developed to facilitate follow-up visits. We sought to assess feasibility of fully digital data processing (FDDP) during ambulatory device follow-up in a high-volume tertiary hospital to provide guidance for future users of FDDP software. A total of 391 patients (mean age, 70 years) presenting to the outpatient department for routine device follow-up were analyzed (pacemaker, 44%; implantable cardioverter defibrillator, 39%; cardiac resynchronization therapy device, 16%). Quality of data transfer and follow-up duration were compared between digital (n = 265) and manual processing of device data (n = 126). Digital data import was successful, complete and correct in 82% of cases when early software versions were used. When using the most recent software version the rate of successful digital data import increased to 100%. Software-based import of interrogation data was complete and without failure in 97% of cases. The mean duration of a follow-up visit did not differ between the two groups (digital 18.7 min vs. manual data transfer 18.2 min). FDDP software was successfully implemented into the ambulatory follow-up of patients with implanted pacemakers and defibrillators. Digital data import into electronic patient management software was feasible and supported the physician's workflow. The total duration of follow-up visits comprising technical device interrogation and clinical actions was not affected in the present tertiary center outpatient cohort.

  11. Clinical presentation and treatment outcome of molar pregnancy: Ten years experience at a Tertiary Care Hospital in Dammam, Saudi Arabia.

    PubMed

    Al-Talib, Ayman A

    2016-01-01

    To study the clinical presentation and treatment outcome of molar pregnancy at a Tertiary Care Hospital in Dammam, Saudi Arabia. Reviewed medical records of all molar pregnancy cases among all the deliveries at a tertiary care hospital in Dammam from 2005 to 2014, after approval by institutional ethical review committee. Data abstracted included patient's age, parity, presenting symptoms, gestational age at diagnosis, uterine size, ultrasonographic findings, BhCG level at the time of diagnosis and at follow-up after evacuation, and blood loss during evacuation. Data was entered and analyzed using Excel; frequency distribution for categorical variables and descriptive statistics for continuous variables were computed. Of a total of 25,000 deliveries in ten years, 22 cases of complete molar pregnancy were encountered: 0.9 cases of molar pregnancy per 1000 pregnancies. Majority of patients (63.7%) were older than 35 years, and were nulliparous (45.5%). The commonest symptom was vaginal bleeding (86.4%) followed by hyperemesis gravidarum (41.0%); Hyperthyroidism was seen in 1 patient (4.5%). Ovarian enlargement by theca-lutin cyst was seen in 3 patients (13.6%). The majority of patients (63.6%) had normal BhCG within 9 weeks (63 days) after suction curettage. The majority of the cases followed a benign course. Aged older than 35 years seems a risk factor and vaginal bleeding is the commonest presenting symptom. Early booking of pregnant women to antenatal care clinics and routine first trimester ultrasound made diagnosis easier and earlier before complications appear.

  12. Tertiary structure of human {Lambda}6 light chains.

    SciT

    Pokkuluri, P. R.; Solomon, A.; Weiss, D. T.

    1999-01-01

    AL amyloidosis is a disease process characterized by the pathologic deposition of monoclonal light chains in tissue. To date, only limited information has been obtained on the molecular features that render such light chains amyloidogenic. Although protein products of the major human V kappa and V lambda gene families have been identified in AL deposits, one particular subgroup--lambda 6--has been found to be preferentially associated with this disease. Notably, the variable region of lambda 6 proteins (V lambda 6) has distinctive primary structural features including the presence in the third framework region (FR3) of two additional amino acid residues thatmore » distinguish members of this subgroup from other types of light chains. However, the structural consequences of these alterations have not been elucidated. To determine if lambda 6 proteins possess unique tertiary structural features, as compared to light chains of other V lambda subgroups, we have obtained x-ray diffraction data on crystals prepared from two recombinant V lambda 6 molecules. These components, isolated from a bacterial expression system, were generated from lambda 6-related cDNAs cloned from bone marrow-derived plasma cells from a patient (Wil) who had documented AL amyloidosis and another (Jto) with multiple myeloma and tubular cast nephropathy, but no evident fibrillar deposits. The x-ray crystallographic analyses revealed that the two-residue insertion located between positions 68 and 69 (not between 66 and 67 as previously surmised) extended an existing loop region that effectively increased the surface area adjacent to the first complementarity determining region (CDR1). Further, an unusual interaction between the Arg 25 and Phe 2 residues commonly found in lambda 6 molecules was noted. However, the structures of V lambda 6 Wil and Jto also differed from each other, as evidenced by the presence in the latter of certain ionic and hydrophobic interactions that we posit increased

  13. Staff happiness and work satisfaction in a tertiary psychiatric centre.

    PubMed

    Baruch, Y; Swartz, M; Sirkis, S; Mirecki, I; Barak, Y

    2013-09-01

    Mental health professionals are at a high risk of burnout. Positive psychology outcomes of staff in acute in-patient psychiatric wards are poorly researched and unclear. To quantify the satisfaction with life and work-life satisfaction of mental health staff at a large university-affiliated tertiary psychiatric centre. We utilized the Satisfaction with Life Scale (SWLS) and the Work-Life Satisfaction Questionnaire (WLSQ). Two hundred and nine out of 450 staff members (46%) participated; mean age 48.2 + 9.9 years; 63% were male. On average the participants had been practising their speciality for 21.1 + 9.8 years (range: 2-48). The mean total SWLS scores differed significantly between professions (P < 0.05). The highest levels of happiness were reported by psychologists and social workers, followed by the administrative staff, the psychiatrists and finally the nursing staff. Staff scored the highest for work as a 'calling' followed by work as a 'career' and the lowest rating for work as a 'job'. The mean total WLSQ score differed between professions, (P < 0.01). The highest levels of work as a calling were reported by psychiatrists (mean 2.87 of possible 5.0), followed by psychologists and social workers, nursing staff and finally administrative staff. Satisfaction with life and work orientation do not correlate among mental health professionals. Although highly motivated and perceiving psychiatry as a 'calling' psychiatrists score low on levels of satisfaction with life. Improving staff happiness may contribute to increase in moral and counter burnout.

  14. Magnesioferrite from the Cretaceous-Tertiary boundary, Caravaca, Spain

    Bohor, B.F.; Foord, E.E.; Ganapathy, R.

    1986-01-01

    Magnesioferrite grading toward magnetite has been identified as a very small but meaningful constituent of the basal iron-rich portion of the Cretaceous-Tertiary (K-T) boundary clay at the Barranco del Gredero section, Caravaca, Spain. This spinel-type phase and others of the spinel group, found in K-T boundary clays at many widely separated sites, have been proposed as representing unaltered remnants of ejecta deposited from an earth-girdling dust cloud formed from the impact of an asteroid or other large bolide at the end of the Cretaceous period. The magnesioferrite occurs as euhedral, frequently skeletal, micron-sized octahedral crystals. The magnesioferrite contains 29 ?? 11 ppb Ir, which accounts for only part of the Ir anomaly at this K-T boundary layer (52 ?? 1 ppb Ir). Major element analyses of the magnesioferrite show variable compositions. Some minor solid solution exists toward hercynite-spinel and chromite-magnesiochromite. A trevorite-nichromite (NiFe2O4NiCr2O4) component is also present. The analyses are very similar to those reported for sites at Furlo and Petriccio, Umbria, Italy. On the basis of the morphology and general composition of the magnesioferrite grains, rapid crystallization at high temperature is indicated, most likely directly from a vapor phase and in an environment of moderate oxygen fugacity. Elemental similarity with metallic alloy injected into rocks beneath two known impact craters suggests that part of the magnesioferrite may be derived from the vaporized chondritic bolide itself, or from the mantle; there is no supporting evidence for its derivation from crustal target rocks. ?? 1986.

  15. Carcinogenicity of methyl-tertiary butyl ether in gasoline.

    PubMed

    Mehlman, Myron A

    2002-12-01

    Methyl tertiary butyl ether (MTBE) was added to gasoline on a nationwide scale in 1992 without prior testing of adverse, toxic, or carcinogenic effects. Since that time, numerous reports have appeared describing adverse health effects of individuals exposed to MTBE, both from inhalation of fumes in the workplace and while pumping gasoline. Leakage of MTBE, a highly water-soluble compound, from underground storage tanks has led to contamination of the water supply in many areas of the United States. Legislation has been passed by many states to prohibit the addition of MTBE to gasoline. The addition of MTBE to gasoline has not accomplished its stated goal of decreasing air pollution, and it has posed serious health risks to a large portion of the population, particularly the elderly and those with respiratory problems, asthma, and skin sensitivity. Reports of animal studies of carcinogenicity of MTBE began to appear in the 1990s, prior to the widespread introduction of MTBE into gasoline. These reports were largely ignored. In ensuing years, further studies have shown that MTBE causes various types of malignant tumors in mice and rats. The National Toxicology Program (NTP) Board of Scientific Counselors' Report on Carcinogens Subcommittee met in December 1998 to consider listing MTBE as "reasonably anticipated to be a human carcinogen." In spite of recommendations from Dr. Bailer, the primary reviewer, and other scientists on the committee, the motion to list MTBE in the report was defeated by a six to five vote, with one abstention. On the basis of animal studies, it is widely accepted that if a chemical is carcinogenic in appropriate laboratory animal test systems, it must be treated as though it were carcinogenic in humans. In the face of compelling evidence, NTP Committee members who voted not to list MTBE as "reasonably anticipated to be a human carcinogen" did a disservice to the general public; this action may cause needless exposure of many to health risks

  16. Attitudes Toward Cognitive Enhancer Use Among New Zealand Tertiary Students.

    PubMed

    Ram, Sanyogita Sanya; Hussainy, Safeera; Henning, Marcus; Stewart, Kay; Jensen, Maree; Russell, Bruce

    2017-09-19

    Cognitive enhancement is the use of prescription stimulant medicines by healthy individuals for nonmedical use in academic settings. Commonly used cognitive enhancers (CEs) include methylphenidate, amphetamines, and modafinil. To understand the motivation to use CEs, it is important to look beyond prevalence and explore the extent to which attitudes, beliefs, and intentions predict the decision to use CEs. The study aimed to investigate what factors explain the decision to use CEs among tertiary students in New Zealand, using the Theory of Planned Behaviour (TPB). Students from the Schools of Pharmacy, Nursing, Medicine, Law, and Accounting at a university in New Zealand were invited to complete a paper-based questionnaire. The questionnaire elicited students' attitudes, subjective norms, and perceived control toward illicit use of CEs using TPB. An exploratory factor analysis was conducted. Response rate was 88.6% (442/499). Students who perceived CE use to be socially and ethically acceptable were more likely to use CEs (odds ratio, OR: 1.56, 95% confidence interval, 95% CI: 1.153-2.105, p = 0.004). Students who were concerned about the health impact of CE use were less likely to use CEs (OR: 0.54, 95% CI: 0.492-0.826, p = 0.001). Students who believed that CE use was approved were more likely to use them (OR: 1.648, CI: 1.193-2.278, p = 0.002). This research supports the notion that the decision to use CEs is not just an autonomous choice that occurs in isolation. Attitudes on the ethical and social acceptability of CE use were more likely to drive the decision to use CEs. The study provides the impetus for an integrative discussion by health care professionals and academics on the impact of attitudes, social norms, and advocates on the decision to use CEs.

  17. Mainstreaming of Climate Change into the Ghanaian Tertiary Educational System

    NASA Astrophysics Data System (ADS)

    Nyarko, B. K.

    2013-12-01

    The impact of Climate Change has a far-reaching implication for economies and people living in the fragile Regions of Africa analysts project that by 2020, between 75 million and 250 million people will be exposed various forms of Climate Change Stresses. Education as a key strategy identified under Agenda 21 has been incorporated into the efforts of various educational institutions as a means of mitigating climate change and enhancing sustainability. Climate Change education offers many opportunities and benefits for educators, researchers, learners, and for wider society, but there are also many challenges, which can hinder the successful mainstreaming of climate change education. The study aims at understanding barriers for Climate Change Education in selected tertiary institutions in Ghana. The study was conducted among Geoscience Departments of the 7 main public universities of Ghana. The transcript analysis identified issues that hinders the mainstreaming of Climate Change, these includes existing levels of knowledge and understanding of the concept of climate change, appreciating the threshold concepts, ineffective teaching of Climate Change and some Departments are slow in embracing Climate Change as a discipline. Hence to develop strategies to mainstream climate change education it is important to recognise that increasing the efficiency and delivery of Climate Change education requires greater attention and coordination of activities and updating the educators knowledge and skill's. Various Ministries should be challenged to develop and integrate climate change into education policies. In the design of curriculum, there is a need to integrate Climate Change Education into curricula without compromising already overstretched programmes of study. There is a need to encourage and enhance innovative teaching approaches such as Problem-based learning (PBL) is an approach that challenges students to learn through engagement in a real problem. Institutions and

  18. Bloodstream infections at a tertiary referral hospital in Yangon, Myanmar.

    PubMed

    Myat, Tin Ohn; Prasad, Namrata; Thinn, Kyi Kyi; Win, Kyu Kyu; Htike, Wah Win; Zin, Khwar Nyo; Murdoch, David R; Crump, John A

    2014-11-01

    Data regarding characteristics of bloodstream infections in Myanmar are limited. Blood culture results from all outpatients and inpatients were extracted from records of the Clinical Microbiology Laboratory, Yangon General Hospital, for the period 2005 through 2013. Of 3865 blood cultures performed, 449 (11.6%) were positive for a pathogenic organism. Gram-negative bacteria was the most common organism group, accounting for 246 (55.5%) of 449 isolations. Staphylococcus aureus was the most common isolate, detected in 171 (38.1%) of 449 blood cultures. From 2005-2008 to 2009-2013 the proportion of all pathogenic isolates that were Gram-positive declined from 52.8% (167/316) to 20.3% (27/133) (p<0.001), whereas the proportion of Gram-negative bacteria rose from 45.6% (144/316) to 78.9% (105/133) (p<0.001), with non-fermentative bacilli accounting for much of this increase. Antimicrobial susceptibility testing demonstrated a high prevalence resistance of S. aureus to first-line antimicrobials such as erythromycin, penicillin and oxacillin. More than half of tested Escherichia coli and Citrobacter species showed resistance to amoxicillin-clavulanic acid, ceftriaxone or gentamicin. Bloodstream infections are common among patients receiving blood culture at a tertiary hospital in Yangon, Myanmar. Our findings suggest that antimicrobial resistance among invasive bacteria is common, similar to patterns described elsewhere in the region, and highlight the need for locally adapted antimicrobial guidelines for sepsis management. © The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  19. Management of penile cancer in a Singapore tertiary hospital.

    PubMed

    Tan, Teck Wei; Chia, Sing Joo; Chong, Kian Tai

    2017-06-01

    To present our experience of managing penile squamous cell carcinoma (SCC) in a tertiary hospital in Singapore and to evaluate the prognostic value of the inflammatory markers neutrophil-lymphocyte ratio (NLR) and lymphocyte-monocyte ratio (LMR). We reviewed our prospectively maintained Institutional Review Board-approved urological cancer database to identify men treated for penile SCC at our centre between January 2007 and December 2015. For all the patients identified, we collected epidemiological and clinical data. In all, 39 patients were identified who were treated for penile SCC in our centre. The median [interquartile range (IQR)] follow-up was 34 (16.5-66) months. Although very few (23%) of our patients with high-risk clinical node-negative underwent prophylactic inguinal lymph node dissection (ILND), they still had excellent 5-year recurrence-free survival (RFS; 90%) and cancer-specific survival (CSS; 90%). At multivariate analysis, higher N stage was significantly associated with worse RFS and CSS. Patients with a high NLR (≥2.8) had significantly higher T-stage ( P  = 0.006) and worse CSS ( P  < 0.001) than those with a low NLR. Patients with a low LMR (<3.3) had significantly higher T-stage ( P  = 0.013) and worse RFS ( P  = 0.009) and CSS ( P  < 0.022) than those with a high LMR. Although very few of our patients with intermediate- and high-risk clinical node-negative SCC underwent prophylactic ILND, they still had excellent 5-year RFS and CSS. However, survival was poor in patients with node-positive disease. The pre-treatment NLR and LMR could serve as biomarkers to predict the prognosis of patients with penile cancer.

  20. Remote Sensing Tertiary Education Meets High Intensity Interval Training

    NASA Astrophysics Data System (ADS)

    Joyce, K. E.; White, B.

    2015-04-01

    Enduring a traditional lecture is the tertiary education equivalent of a long, slow, jog. There are certainly some educational benefits if the student is able to maintain concentration, but they are just as likely to get caught napping and fall off the back end of the treadmill. Alternatively, a pre-choreographed interactive workshop style class requires students to continually engage with the materials. Appropriately timed breaks or intervals allow students to recover briefly before being increasingly challenged throughout the class. Using an introductory remote sensing class at Charles Darwin University, this case study presents a transition from the traditional stand and deliver style lecture to an active student-led learning experience. The class is taught at undergraduate and postgraduate levels, with both on-campus as well as online distance learning students. Based on the concept that active engagement in learning materials promotes 'stickiness' of subject matter, the remote sensing class was re-designed to encourage an active style of learning. Critically, class content was reviewed to identify the key learning outcomes for the students. This resulted in a necessary sacrifice of topic range for depth of understanding. Graduates of the class reported high levels of enthusiasm for the materials, and the style in which the class was taught. This paper details a number of techniques that were used to engage students in active and problem based learning throughout the semester. It suggests a number of freely available tools that academics in remote sensing and related fields can readily incorporate into their teaching portfolios. Moreover, it shows how simple it can be to provide a far more enjoyable and effective learning experience for students than the one dimensional lecture.

  1. Fabrication of the LSST monolithic primary-tertiary mirror

    NASA Astrophysics Data System (ADS)

    Tuell, Michael T.; Martin, Hubert M.; Burge, James H.; Ketelsen, Dean A.; Law, Kevin; Gressler, William J.; Zhao, Chunyu

    2012-09-01

    As previously reported (at the SPIE Astronomical Instrumentation conference of 2010 in San Diego1), the Large Synoptic Survey Telescope (LSST) utilizes a three-mirror design in which the primary (M1) and tertiary (M3) mirrors are two concentric aspheric surfaces on one monolithic substrate. The substrate material is Ohara E6 borosilicate glass, in a honeycomb sandwich configuration, currently in production at The University of Arizona’s Steward Observatory Mirror Lab. We will provide an update to the status of the mirrors and metrology systems, which have advanced from concepts to hardware in the past two years. In addition to the normal requirements for smooth surfaces of the appropriate prescriptions, the alignment of the two surfaces must be accurately measured and controlled in the production lab, reducing the degrees of freedom needed to be controlled in the telescope. The surface specification is described as a structure function, related to seeing in excellent conditions. Both the pointing and centration of the two optical axes are important parameters, in addition to the axial spacing of the two vertices. This paper details the manufacturing process and metrology systems for each surface, including the alignment of the two surfaces. M1 is a hyperboloid and can utilize a standard Offner null corrector, whereas M3 is an oblate ellipsoid, so it has positive spherical aberration. The null corrector is a phase-etched computer-generated hologram (CGH) between the mirror surface and the center-of-curvature. Laser trackers are relied upon to measure the alignment and spacing as well as rough-surface metrology during looseabrasive grinding.

  2. Optical testing of the LSST combined primary/tertiary mirror

    NASA Astrophysics Data System (ADS)

    Tuell, Michael T.; Martin, Hubert M.; Burge, James H.; Gressler, William J.; Zhao, Chunyu

    2010-07-01

    The Large Synoptic Survey Telescope (LSST) utilizes a three-mirror design in which the primary (M1) and tertiary (M3) mirrors are two concentric aspheric surfaces on one monolithic substrate. The substrate material is Ohara E6 borosilicate glass, in a honeycomb sandwich configuration, currently in production at The University of Arizona's Steward Observatory Mirror Lab. In addition to the normal requirements for smooth surfaces of the appropriate prescriptions, the alignment of the two surfaces must be accurately measured and controlled in the production lab. Both the pointing and centration of the two optical axes are important parameters, in addition to the axial spacing of the two vertices. This paper describes the basic metrology systems for each surface, with particular attention to the alignment of the two surfaces. These surfaces are aspheric enough to require null correctors for each wavefront. Both M1 and M3 are concave surfaces with both non-zero conic constants and higher-order terms (6th order for M1 and both 6th and 8th orders for M3). M1 is hyperboloidal and can utilize a standard Offner null corrector. M3 is an oblate ellipsoid, so has positive spherical aberration. We have chosen to place a phase-etched computer-generated hologram (CGH) between the mirror surface and the center-of-curvature (CoC), whereas the M1 null lens is beyond the CoC. One relatively new metrology tool is the laser tracker, which is relied upon to measure the alignment and spacings. A separate laser tracker system will be used to measure both surfaces during loose abrasive grinding and initial polishing.

  3. Tertiary structural evolution of the Gangdese thrust system southeastern Tibet

    SciT

    Yin, An; Harrison, M.; Ryerson, F.J.

    1994-09-10

    Structural and thermochronological investigations of southern Tibet (Xizang) suggest that intracontinental thrusting has been the dominant cause for formation of thickened crust in the southernmost Tibetan plateau since late Oligocene. Two thrust systems are documented in this study: the north dipping Gangdese system (GTS) and the younger south dipping Renbu-Zedong system (RZT). West of Lhasa, the Gangdese thrust juxtaposes the Late Cretaceous forearc basin deposits of the Lhasa Block (the Xigaze Group) over the Tethyan sedimentary rocks of the Indian plate, whereas east of Lhasa, the fault juxtaposes the Late Cretaceous-Eocene, Andean-type arc (the Gangdese batholith) over Tethyan sedimentary rocks.more » Near Zedong, 150 km southeast of Lhasa, the Gangdese thrust is marked by a >200-m-thick mylonitic shear zone that consists of deformed granite and metasedimentary rocks. A major south dipping backthrust in the hanging wall of the Gangdese thrust puts the Xigaze Group over Tertiary conglomerates and the Gangdese plutonics north of Xigaze and west of Lhasa. A lower age bound for the Gangdese thrust of 18.3{+-}0.5 Ma is given by crosscutting relationships. The timing of slip on the Gangdese thrust is estimate to be 27-23 Ma from {sup 40}Ar/{sup 39}Ar thermochronology, and a displacement of at least 46{+-}9 km is indicated near Zedong. The age of the Gangdese thrust (GT) is consistent with an upper age limit of {approximately}24 Ma for the initiation of movement on the Main Central thrust. In places, the younger Renbu-Zedong fault is thrust over the trace of the GT, obscuring its exposure. The RZT appears to have been active at circa 18 Ma but had ceased movement by 8{+-}1 Ma. The suture between India and Asia has been complexely modified by development of the GTS, RZT, and, locally, strike-slip and normal fault systems. 64 refs., 14 figs., 2 tabs.« less

  4. RETINAL DISEASES IN A TERTIARY HOSPITAL IN SOUTHERN NIGERIA.

    PubMed

    Uhumwangho, O M; Itina, E I

    2015-01-01

    Retinal diseases are an important and common cause of ophthalmic consultation. To determine the pattern of retinal diseases in the ophthalmic department of a tertiary hospital in Southern Nigeria. A retrospective review of the case folders of patients with retinal pathologies seen between 2012 and 2013 was performed. Relevant demographic and clinical data was recorded. Analysis was performed for frequencies, proportions and percentages with the GraphPad Instat Software, Inc. version V2.05a program, San Diego, CA. There were 185 patients made of 94 (50.8%) males and 91 (49.2%) females with a peak age group of 61-70 years, (range 1-85 years) who made consultations for retinal diseases. Age related macular degeneration, 37(15.0%), and macula hole, 10(4.0%), were the common macula pathologies while retinal detachment, 11(4.5%), was the most common condition that required emergency vitreo-retinal surgical intervention. Diabetic retinopathy/maculopathy, 31(12.6%), hypertensive retinopathy 22(8.9%), and retinal vascular occlusion 12(4.8%), were the common retinal vascular diseases found. Bilateral visual impairment (low vision and blindness) from retinal diseases was present in 28(14.4%) persons. The common vitreo-retinal treatment options were use of intravitreal antivascular endothelial growth factors 32(13.0%), laser 16(6.5%), and vitreoretinal surgery in 22(8.9%) eyes. Retinal diseases remain an important cause of ophthalmic consultation and visual loss. Provision of facilities to manage these conditions will improve service delivery and quality of lives of affected patients.

  5. Urgent tracheostomy: four-year experience in a tertiary hospital.

    PubMed

    Costa, Liliana; Matos, Ricardo; Júlio, Sara; Vales, Fernando; Santos, Margarida

    2016-01-01

    Urgent airway management is one of the most important responsibilities of otolaryngologists, often requiring a multidisciplinary approach. Urgent surgical airway intervention is indicated when an acute airway obstruction occurs or there are intubation difficulties. In these situations, surgical tracheostomy becomes extremely important. We retrospectively studied the patients who underwent surgical tracheostomy from 2011 to 2014 by an otolaryngologist team at the operating theater of the emergency department of a tertiary hospital. Indications, complications and clinical evolution of the patients were reviewed. The study included 56 patients (44 men and 12 women) with a median age of 55 years. The procedure was performed under local anesthesia in 21.4% of the patients. Two (3.6%) patients were subjected to conversion from cricothyrostomy to tracheostomy. Head and neck neoplasm was indicated in 44.6% of the patients, deep neck infection in 19.6%, and bilateral vocal fold paralysis in 10.7%. Stridor was the most frequent signal (51.8%). Of the 56 patients, 15 were transferred to another hospital. Among the other 41 patients, 21 were decannulated (average time: 4 months), and none of them were cancer patients. Complications occurred in 5 (12.2%) patients: hemorrhage in 3, surgical wound infection in 1, and cervico-thoracic subcutaneous emphysema in 1. No death was related to the procedure. Urgent tracheostomy is a life-saving procedure for patients with acute airway obstruction or with difficult intubation. It is a safe and effective procedure, with a low complication rate, and should be performed before the patient's clinical status turns into a surgical emergency situation.

  6. Indications for and outcomes of tertiary referrals in refractive surgery.

    PubMed

    Patryn, Eliza K; Vrijman, Violette; Nieuwendaal, Carla P; van der Meulen, Ivanka J E; Mourits, Maarten P; Lapid-Gortzak, Ruth

    2014-01-01

    To review the spectrum of disease, symptomatology, and management offered to patients referred for a second opinion after refractive surgery. A prospective cohort study was done on all patients referred from October 1, 2006, to September 30, 2011, to a tertiary eye clinic after refractive surgery of any kind (ie, corneal laser surgery, conductive keratoplasty, radial keratotomy, phakic implants, refractive lens exchanges, or any combination thereof). Data analysis was performed on all demographic and clinical aspects of this cohort, including the initial complaint, type of referral, number of complaints, procedure previously performed, diagnosis at our center, type of advice given, and rate and type of surgical intervention. One hundred thirty-one eyes (69 patients) were included. Corneal refractive surgery was performed in 82% (108 eyes), and 11% (14 eyes) were seen after phakic intraocular lens (PIOL) implantation and 7% (9 eyes) after refractive lens exchange. The most common diagnoses were tear film dysfunction (30 eyes, 23%), residual refractive error (25 eyes, 19%), and cataract (20 eyes, 15%). Most patients (42 patients, 61%) were treated conservatively. In 27 patients (39%), 36 eyes (28%) were managed surgically. Severe visual loss was seen in 1 eye. No major problems were found in most second opinions after refractive surgery referral. Dry eyes, small residual refractive error, or higher-order aberrations were the most common complaints. Surgical intervention was needed in 36 eyes (28%), almost half of which were cataract extractions. Severe visual loss was seen in 1 eye with a PIOL. There was no incidence of severe visual loss in keratorefractive and refractive lens exchange procedures. Copyright 2014, SLACK Incorporated.

  7. Binocular diplopia in a tertiary hospital: Aetiology, diagnosis and treatment.

    PubMed

    Merino, P; Fuentes, D; Gómez de Liaño, P; Ordóñez, M A

    2017-12-01

    To study the causes, diagnosis and treatment in a case series of binocular diplopia. A retrospective chart review was performed on patients seen in the Diplopia Unit of a tertiary centre during a one-year period. Diplopia was classified as: acute≤1 month since onset; subacute (1-6 months); and chronic (>6 months). Resolution of diplopia was classified as: spontaneous if it disappeared without treatment, partial if the course was intermittent, and non-spontaneous if treatment was required. It was considered a good outcome when diplopia disappeared completely (with or without treatment), or when diplopia was intermittent without significantly affecting the quality of life. A total of 60 cases were included. The mean age was 58.65 years (60% female). An acute or subacute presentation was observed in 60% of the patients. The mean onset of diplopia was 82.97 weeks. The most frequent aetiology was ischaemic (45%). The most frequent diagnosis was sixth nerve palsy (38.3%), followed by decompensated strabismus (30%). Neuroimaging showed structural lesions in 17.7% of the patients. There was a spontaneous resolution in 28.3% of the cases, and there was a good outcome with disappearance of the diplopia in 53.3% at the end of the study. The most frequent causes of binocular diplopia were cranial nerve palsies, especially the sixth cranial nerve, followed by decompensated strabismus. Structural lesions in imaging tests were more than expected. Only one third of patients had a spontaneous resolution, and half of them did not have a good outcome despite of treatment. Copyright © 2017 Sociedad Española de Oftalmología. Publicado por Elsevier España, S.L.U. All rights reserved.

  8. Scrub Typhus in a Tertiary Care Hospital in North India.

    PubMed

    Sharma, Navneet; Biswal, Manisha; Kumar, Abhay; Zaman, Kamran; Jain, Sanjay; Bhalla, Ashish

    2016-08-03

    Scrub typhus, a zoonotic disease caused by the bacterium Orientia tsutsugamushi, has become endemic in many parts of India. We studied the clinical profile of this infection in 228 patients that reported to this tertiary care center from July 2013 to December 2014. The median age of patients was 35 years (interquartile range = 24.5-48.5 years), and 111 were males and 117 females. A high-grade fever occurred in 85%, breathlessness in 42%, jaundice in 32%, abdominal pain in 28%, renal failure in 11%, diarrhea in 10%, rashes in 9%, and seizures in 7%. Common laboratory abnormalities at presentation were a deranged hepatic function in 61%, anemia in 54%, leukopenia in 15%, and thrombocytopenia in 90% of our patients. Acute kidney injury (32%), acute respiratory distress syndrome (ARDS) (25%), and disseminated intravascular coagulation (DIC) (16%) were the commonest complications. A hepatorenal syndrome was seen in 38% and multiple organ dysfunction syndrome (MODS) in 20% patients. The overall case fatality rate was 13.6%. In univariate analysis, ARDS requiring mechanical ventilation, acute kidney injury requiring hemodialysis, hypotension requiring inotropic support, central nervous system dysfunction at presentation, and MODS were inversely associated with survival. Survival was significantly higher in patients that presented with a duration of fever < 10 days compared with those that presented ≥ 12 days (P < 0.05) after onset. In conclusion, scrub typhus has become a leading infectious disease in north India and an important cause of infectious fever. An increasing awareness of this disease coupled with prompt management will go a long way in reducing both morbidity and mortality from this disease. © The American Society of Tropical Medicine and Hygiene.

  9. The global Cretaceous-Tertiary fire: Biomass or fossil carbon

    NASA Technical Reports Server (NTRS)

    Gilmour, Iain; Guenther, Frank

    1988-01-01

    The global soot layer at the K-T boundary indicates a major fire triggered by meteorite impact. However, it is not clear whether the principal fuel was biomass or fossil carbon. Forests are favored by delta value of C-13, which is close to the average for trees, but the total amount of elemental C is approximately 10 percent of the present living carbon, and thus requires very efficient conversion to soot. The PAH was analyzed at Woodside Creek, in the hope of finding a diagnostic molecular marker. A promising candidate is 1-methyl-7-isopropyl phenanthrene (retene,), which is probably derived by low temperature degradation of abietic acid. Unlike other PAH that form by pyrosynthesis at higher temperatures, retene has retained the characteristic side chains of its parent molecule. A total of 11 PAH compounds were identified in the boundary clay. Retene is present in substantial abundance. The identification was confirmed by analysis of a retene standard. Retene is characteristic of the combustion of resinous higher plants. Its formation depends on both temperature and oxygen access, and is apparently highest in oxygen-poor fires. Such fires would also produce soot more efficiently which may explain the high soot abundance. The relatively high level of coronene is not typical of a wood combustion source, however, though it can be produced during high temperature pyrolysis of methane, and presumably other H, C-containing materials. This would require large, hot, low O2 zones, which may occur only in very large fires. The presence of retene indicates that biomass was a significant fuel source for the soot at the Cretaceous-Tertiary boundary. The total amount of elemental C produced requires a greater than 3 percent soot yield, which is higher than typically observed for wildfires. However, retene and presumably coronene imply limited access of O2 and hence high soot yield.

  10. Patient Understanding of Hypoglycemia in Tertiary Referral Centers.

    PubMed

    Cho, Nan Hee; Kim, Nam Kyung; Han, Eugene; Hong, Jun Hwa; Jeon, Eon Ju; Moon, Jun Sung; Seo, Mi Hae; Lee, Ji Eun; Seo, Hyun Ae; Kim, Mi Kyung; Kim, Hye Soon

    2018-02-01

    Hypoglycemia is an important complication in the treatment of patients with diabetes. We surveyed the insight by patients with diabetes into hypoglycemia, their hypoglycemia avoidance behavior, and their level of worry regarding hypoglycemia. A survey of patients with diabetes, who had visited seven tertiary referral centers in Daegu or Gyeongsangbuk-do, Korea, between June 2014 and June 2015, was conducted. The survey contained questions about personal history, symptoms, educational experience, self-management, and attitudes about hypoglycemia. Of 758 participants, 471 (62.1%) had experienced hypoglycemia, and 250 (32.9%) had experienced hypoglycemia at least once in the month immediately preceding the study. Two hundred and forty-two (31.8%) of the participants had received hypoglycemia education at least once, but only 148 (19.4%) knew the exact definition of hypoglycemia. Hypoglycemic symptoms identified by the participants were dizziness (55.0%), sweating (53.8%), and tremor (40.8%). They mostly chose candy (62.1%), chocolate (37.7%), or juice (36.8%) as food for recovering hypoglycemia. Participants who had experienced hypoglycemia had longer duration of diabetes and a higher proportion of insulin usage. The mean scores for hypoglycemia avoidance behavior and worry about hypoglycemia were 21.2±10.71 and 23.38±13.19, respectively. These scores tended to be higher for participants with higher than 8% of glycosylated hemoglobin, insulin use, and experience of emergency room visits. Many patients had experienced hypoglycemia and worried about it. We recommend identifying patients that are anxious about hypoglycemia and educating them about what to do when they develop hypoglycemic symptoms, especially those who have a high risk of hypoglycemia. Copyright © 2018 Korean Diabetes Association

  11. Male hypogonadism at a tertiary care hospital in Karachi, Pakistan.

    PubMed

    Ram, Nanik; Asghar, Ali; Hashmi, Fauzan; Islam, Najmul

    2012-01-01

    Male hypogonadism is defined as 'inadequate gonadal function, manifested by deficiency in gametogenesis and/or secretion of gonadal hormones'. Signs and symptoms of hypogonadism depend primarily on the age of onset. It can be classified according to the site primarily involved: the gonads, the hypothalamus, or the pituitary gland. The objective this study was to determine the presentation and aetiology of male hypogonadism seen in a tertiary care hospital. This cross-sectional study was conducted at Endocrine Clinics, Aga Khan University Hospital Karachi. Data of male patients with hypogonadism who attended clinics during January 2009 to August 2011 were reviewed. All male patients with clinical and biochemical evidence of hypogonadism were included in the study. Patients with Diabetes Mellitus, Metabolic Syndrome, Andropause, AIDS, Chronic Renal Failure, and Cirrhosis were excluded. Mean +/- SD were computed for quantitative variables. Frequency and percentages were computed for qualitative variables. Aetiology of male hypogonadism was categorised as primary and secondary hypogonadism. A total of 85 patients with male hypogonadism attended the endocrine clinic. Mean age of patients was 25 +/- 10 years. Clinical presentations were small genitalia (65%), absent secondary sexual characteristics (53%), not attained puberty (47%), infertility (53%), erectile dysfunction (41%) and loss of libido (29%). Seventy-three (86%) patients had hypogonadotrophic hypogonadism (secondary hypogonadism) and 12 (14%) patients had hypergonadotrophic hypogonadism (primary hypogonadism). Among the patients with hypogonadotrophic hypogonadism 38 had idiopathic hypogonadotrophic hypogonadsim, 7 had pituitary adenoma, 6 had empty sella syndrome, 3 had Kallman's syndrome, and 1 patient had haemosiderosis due to thalassaemia major; 18 patients did not undergo brain imaging. Small genitalia, absent secondary sexual characteristics and infertility were the main presenting features of hypogonad

  12. Macromolecular ab initio phasing enforcing secondary and tertiary structure.

    PubMed

    Millán, Claudia; Sammito, Massimo; Usón, Isabel

    2015-01-01

    Ab initio phasing of macromolecular structures, from the native intensities alone with no experimental phase information or previous particular structural knowledge, has been the object of a long quest, limited by two main barriers: structure size and resolution of the data. Current approaches to extend the scope of ab initio phasing include use of the Patterson function, density modification and data extrapolation. The authors' approach relies on the combination of locating model fragments such as polyalanine α-helices with the program PHASER and density modification with the program SHELXE. Given the difficulties in discriminating correct small substructures, many putative groups of fragments have to be tested in parallel; thus calculations are performed in a grid or supercomputer. The method has been named after the Italian painter Arcimboldo, who used to compose portraits out of fruit and vegetables. With ARCIMBOLDO, most collections of fragments remain a 'still-life', but some are correct enough for density modification and main-chain tracing to reveal the protein's true portrait. Beyond α-helices, other fragments can be exploited in an analogous way: libraries of helices with modelled side chains, β-strands, predictable fragments such as DNA-binding folds or fragments selected from distant homologues up to libraries of small local folds that are used to enforce nonspecific tertiary structure; thus restoring the ab initio nature of the method. Using these methods, a number of unknown macromolecules with a few thousand atoms and resolutions around 2 Å have been solved. In the 2014 release, use of the program has been simplified. The software mediates the use of massive computing to automate the grid access required in difficult cases but may also run on a single multicore workstation (http://chango.ibmb.csic.es/ARCIMBOLDO_LITE) to solve straightforward cases.

  13. Prelude and Fugue, predicting local protein structure, early folding regions and structural weaknesses.

    PubMed

    Kwasigroch, Jean Marc; Rooman, Marianne

    2006-07-15

    Prelude&Fugue are bioinformatics tools aiming at predicting the local 3D structure of a protein from its amino acid sequence in terms of seven backbone torsion angle domains, using database-derived potentials. Prelude(&Fugue) computes all lowest free energy conformations of a protein or protein region, ranked by increasing energy, and possibly satisfying some interresidue distance constraints specified by the user. (Prelude&)Fugue detects sequence regions whose predicted structure is significantly preferred relative to other conformations in the absence of tertiary interactions. These programs can be used for predicting secondary structure, tertiary structure of short peptides, flickering early folding sequences and peptides that adopt a preferred conformation in solution. They can also be used for detecting structural weaknesses, i.e. sequence regions that are not optimal with respect to the tertiary fold. http://babylone.ulb.ac.be/Prelude_and_Fugue.

  14. Mass Wasting during the Cretaceous/Tertiary Transition in the North Atlantic: Relationship to the Chicxulub Impact?

    NASA Astrophysics Data System (ADS)

    Mateo, Paula; Keller, Gerta; Adatte, Thierry; Spangenberg, Jorge

    2015-04-01

    Deep-sea sections in the North Atlantic are claimed to contain the most complete sedimentary records and ultimate proof that the Chicxulub impact is Cretaceous-Tertiary boundary (KTB) in age and caused the mass extinction. A multi-disciplinary study of North Atlantic DSDP Sites 384, 386 and 398, based on high-resolution planktonic foraminiferal biostratigraphy, carbon and oxygen stable isotopes, clay and whole-rock mineralogy and granulometry, reveals the age, stratigraphic completeness and nature of sedimentary disturbances. Results show a major KTB hiatus at Site 384 with zones CF1, P0 and P1a missing, spanning at least ~540 ky, similar to other North Atlantic and Caribbean localities associated with tectonic activity and Gulf Stream erosion. At Sites 386 and 398, discrete intervals of disturbed sediments with mm-to-cm-thick spherule layers have previously been interpreted as KTB age impact-generated earthquakes destabilizing continental margins prior to settling of impact spherules. However, improved age control based on planktonic foraminifera indicates deposition in the early Danian zone P1a(2) (upper Parvularugoglobigerina eugubina zone) more than 100 ky after the KTB. At Site 386, two intervals of white chalk contain very small (<63 μm) early Danian zone P1a(2) (65%) and common reworked Cretaceous (35%) species, in contrast to the in situ red-brown and green abyssal clays that are devoid of carbonate. In addition, high calcite, mica and kaolinite and upward-fining are observed in the chalks, indicating downslope transport from shallow waters and sediment winnowing via distal turbidites. At Site 398, convoluted red to tan sediments with early Danian and reworked Cretaceous species represent slumping of shallow water sediments as suggested by dominance of mica and low smectite compared to in situ deposition. We conclude that mass wasting was likely the result of earthquakes associated with increased tectonic activity in the Caribbean and the Iberian Peninsula

  15. Early Rockets

    2004-04-15

    This photograph is of the engine for the Redstone rocket. The Redstone ballistic missile was a high-accuracy, liquid-propelled, surface-to-surface missile developed by the Army Ballistic Missile Agency, Redstone Arsenal, in Huntsville, Alabama, under the direction of Dr. von Braun. The Redstone engine was a modified and improved version of the Air Force's Navaho cruise missile engine of the late forties. The A-series, as this would be known, utilized a cylindrical combustion chamber as compared with the bulky, spherical V-2 chamber. By 1951, the Army was moving rapidly toward the design of the Redstone missile, and the production was begun in 1952. Redstone rockets became the "reliable workhorse" for America's early space program. As an example of its versatility, the Redstone was utilized in the booster for Explorer 1, the first American satellite, with no major changes to the engine or missile.

  16. Early Rockets

    2004-04-15

    The image depicts Redstone missile being erected. The Redstone ballistic missile was a high-accuracy, liquid-propelled, surface-to-surface missile developed by Army Ballistic Missile Agency, Redstone Arsenal, in Huntsville, Alabama, under the direction of Dr. von Braun. The Redstone engine was a modified and improved version of the Air Force's Navaho cruise missile engine of the late forties. The A-series, as this would be known, utilized a cylindrical combustion chamber as compared with the bulky, spherical V-2 chamber. By 1951, the Army was moving rapidly toward the design of the Redstone missile, and the production was begun in 1952. Redstone rockets became the "reliable workhorse" for America's early space program. As an example of the versatility, Redstone was utilized in the booster for Explorer 1, the first American satellite, with no major changes to the engine or missile

  17. Early Rockets

    1958-05-15

    Redstone missile No. 1002 on the launch pad at Cape Canaveral, Florida, on May 16, 1958. The Redstone ballistic missile was a high-accuracy, liquid-propelled, surface-to-surface missile developed by the Army Ballistic Missile Agency, Redstone Arsenal, in Huntsville, Alabama, under the direction of Dr. von Braun. The Redstone engine was a modified and improved version of the Air Force's Navaho cruise missile engine of the late forties. The A-series, as this would be known, utilized a cylindrical combustion chamber as compared with the bulky, spherical V-2 chamber. By 1951, the Army was moving rapidly toward the design of the Redstone missile, and production was begun in 1952. Redstone rockets became the "reliable workhorse" for America's early space program. As an example of the versatility, Redstone was utilized in the booster for Explorer 1, the first American satellite, with no major changes to the engine or missile

  18. [Spectrum of primary immunodeficiencies in a tertiary hospital over a period of 10 years].

    PubMed

    Martín-Nalda, A; Soler-Palacín, P; Español Borén, T; Caragol Urgelles, I; Díaz de Heredia Rubio, C; Figueras Nadal, C

    2011-02-01

    More than 200 primary immunodeficiencies (PID) have been described and about 60% present during childhood. Early diagnosis and treatment have been shown to improve patient outcome. Analysis of patients with a PID diagnosed in a paediatric tertiary care hospital-referral centre over a period of 10 years. Medical records of all paediatric patients followed up in our unit were retrospectively reviewed. Clinical and epidemiological features, laboratory tests, therapy and outcome were analysed. One hundred and eighty nine patients were followed up in this period of time. Antibody disorders were the most common diagnosis. In our series, clinical presentation at diagnosis were: recurrent respiratory infections in selective IgA deficiency and common variable immunodeficiency (CVID) patients, failure to thrive and opportunistic infections (mainly viral infections) in patients with severe combined immunodeficiency (SCID), skin abscesses (Staphylococcus aureus, Serratia spp.) and complicated pneumonia (Aspergillus spp., Rhodococcus equi) in chronic granulomatous disease, congenital heart disease and consistent phenotype in 22q11 deletion syndrome, skin abscesses and ecthyma gangrenosum in severe congenital neutropenia and opportunistic infections and sepsis (Pseudomonas aeruginosa) in children with X-linked agammaglobulinaemia (XLA). Lymphoproliferative disorders were common in CVID. No malignancies were observed during this period. One patient with XLA developed chronic encephalitis. All patients with CVID and XLA were receiving immunoglobulin replacement therapy (8 intravenous and 14 (since 2006) subcutaneous route) and in all but two SCID patients, stem cell transplantation was performed. Outcome was good in most of them except 8 SCID (2 prior and 6 after transplantation), 3 Wiskott-Aldrich syndrome, 1 complete DiGeorge, 1 chronic granulomatous disease and 1 ataxia-telangiectasia patients who died during follow-up. The vast majority of patients included in this series

  19. Strontium and oxygen isotopic variations in Mesozoic and Tertiary plutons of central Idaho

    Fleck, R.J.; Criss, R.E.

    1985-01-01

    Regional variations in initial 87Sr/86Sr ratios (ri) of Mesozoic plutons in central Idaho locate the edge of Precambrian continental crust at the boundary between the late Paleozoic-Mesozoic accreted terranes and Precambrian sialic crust in western Idaho. The ri values increase abruptly but continuously from less than 0.704 in the accreted terranes to greater than 0.708 across a narrow, 5 to 15 km zone, characterized by elongate, lens-shaped, highly deformed plutons and schistose metasedimentary and metavolcanic units. The chemical and petrologic character of the plutons changes concomitantly from ocean-arc-type, diorite-tonalite-trondhjemite units to a weakly peraluminous, calcic to calcalkalic tonalite-granodiorite-granite suite (the Idaho batholith). Plutons in both suites yield Late Cretaceous ages, but Permian through Early Cretaceous bodies are confined to the accreted terranes and early Tertiary intrusions are restricted to areas underlain by Precambrian crust. The two major terranes were juxtaposed between 75 and 130 m.y. ago, probably between 80 and 95 m.y. Oxygen and strontium isotopic ratios and Rb and Sr concentrations of the plutonic rocks document a significant upper-crustal contribution to the magmas that intrude Precambrian crust. Magmas intruding the arc terranes were derived from the upper mantle/subducted oceanic lithosphere and may have been modified by anatexis of earlier island-arc volcanic and sedimentary units. Plutons near the edge of Precambrian sialic crust represent simple mixtures of the Precambrian wall-rocks with melts derived from the upper mantle or subducted oceanic lithosphere with ri of 0.7035. Rb/Sr varies linearly with ri, producing "pseudoisochrons" with apparent "ages" close to the age of the wall rocks. Measured ??18O values of the wall rocks are less than those required for the assimilated end-member by Sr-O covariation in the plutons, however, indicating that wall-rock ??18O was reduced significantly by exchange with

  20. Mid-crustal flow during Tertiary extension in the Ruby Mountains core complex, Nevada

    MacCready, T.; Snoke, A.W.; Wright, J.E.; Howard, K.A.

    1997-01-01

    Structural analysis and geochronologic data indicate a nearly orthogonal, late Eocene-Oligocene flow pattern in migmatitic infrastructure immediately beneath the kilometer-thick, extensional, mylonitic shear zone of the Ruby Mountains metamorphic core complex, Nevada. New U-Pb radiometric dating indicates that the development of a northward-trending lineation in the infrastructure is partly coeval with the development of a pervasive, west-northwest-trending lineation in the mylonitic shear zone. U-Pb monazite data from the leucogranite orthogneiss of Thorpe Creek indicate a crystallization age of ca. 36-39 Ma. Zircon fractions from a biotite monzogranite dike yield an age of ca. 29 Ma. The three dated samples from these units exhibit a penetrative, approximately north-south-trending elongation lineation. This lineation is commonly defined by oriented bundles of sillimanite and/or elongated aggregates of quartz and feldspar, indicating a synmetamorphic and syndeformational origin. The elongation lineation can be interpreted as a slip line in the flow plane of the migmatitic, nonmylonitic infrastructural core of the northern Ruby Mountains. A portion of this midcrustal flow is coeval with the well-documented, west-northwest sense of slip in the structurally overlying kilometer-thick, mid-Tertiary mylonitic shear zone. Lineations in the mylonitic zone are orthogonal to those in the deeper infrastructure, suggesting fundamental plastic decoupling between structural levels in this core complex. Furthermore, the infrastructure is characterized by overlapping, oppositely verging fold nappes, which are rooted to the east and west. One of the nappes may be synkinematic with the intrusion of the late Eocene orthogneiss of Thorpe Creek. In addition, the penetrative, elongation lineation in the infrastructure is subparallel to hinge lines of parasitic folds developed synchronous with the fold nappes, suggesting a kinematically related evolution. The area is evaluated in terms

  1. Cosmic Genes in the Cretaceous-Tertiary transition

    NASA Astrophysics Data System (ADS)

    Wallis, M. K.

    2003-07-01

    It is proposed that genes coding for Aib-polypeptides arose early on in the K/T transition, presumed from the Earth's accretion of interplanetary (comet) dust. Aib-fungi flourished because of the evolutionary advantage of novel antibiotics. The stress on Cretaceous biology led directly and indirectly to mass species extinctions, including many dinosaur species, in the epoch preceding the Chicxulub impact.

  2. Neonatal Transport - Experience of a Tertiary Care Hospital of Bangladesh.

    PubMed

    Dey, S K; Sharker, S; Jahan, I; Moni, S C; Shabuj, K H; Chisti, M J; Mannan, M A; Shahidullah, M

    2017-01-01

    Safe transportation is mostly an unnoticed neonatal health issue in Bangladesh and no documentation is available regarding the existing practices. So this study was intended to document transport status of the referred newborn to a tertiary care hospital. This observational study included 150 out born neonates over 12 months period transported from various places to NICU, Bangabandhu Sheikh Mujib Medical University (BSMMU) from May 2015 to April 2016. A structured data collection form was used to record information categorized into pre-transport, during transport and at admission. At admission detailed clinical assessment of the baby was done and recorded. Outcome was determined as discharge or death. Of 150 transported neonates, two-third were preterm 115(77%) & LBW 113(75%). Common indications for referral were prematurity and sepsis. Most of the patients were referred from private hospital 107(71%). Majority of newborns (86%) were referred from hospitals of Dhaka city while only 14% were referred from outside Dhaka. Referral notes were supplied in most of the cases 134(89%) but comprehensive information was obtainable only in 3 cases. Although main transport vehicle was ambulance 130(87%), medical personnel accompanied the sick baby only in 6(4%) of cases. The distance traveled was less than 10 kilometers (kms) in 95(63%) and more than 100 km in 10(7%) of enrolled neonates. Transport time was less than 1 hour in 72(48%), 1-6 hours in 66(44%) and more than 6 hours in 12(8%) of cases. Nearly two third of newborn were transported after office period, 107(72%). At admission 21(14%) babies had hypothermia, 8(7.62%) hypoglycemia, 16(11%), poor perfusion 28(19%), low saturation 27(18%). Hyperthermia & hyperglycemia were observed in 8(5%) & 7(5%) cases respectively. Of the total 150 babies referred, 17(11%) died. While comparing with discharged newborn, died newborn were more frequent sufferer of hypothermia (p value 0.007) and low saturation (p value 0.049) at

  3. Deccan volcanism at the Cretaceous-Tertiary boundary

    NASA Technical Reports Server (NTRS)

    Courtillot, V.; Vandamme, D.; Besse, J.

    1988-01-01

    The accuracy with which one can claim that Deccan trap volcanism occurred at the Cretaceous-Tertiary boundary (KTB) over a very short time interval is of key importance in deciding whether a volcanic origin of the KTB events should be taken seriously. In the two years since paleomagnetic, paleontological and geodynamic evidence was published, further data have become available and the case now appears to be well constrained. The Ar-40/Ar-39 results from six labs have yielded some 24 reliable plateau ages that narrow the age range to 65 to 69 Ma. Moreover, it appears that a significant part of this range results from inter-lab spread and possible minor alteration. Paleontology demonstrates that volcanism started in the Maestrichtian, more precisely in the A. mayaroensis zone. Paleomagnetism shows that volcanism spanned only 3 chrons and only one correlation remains possible, that of the main central reversed chron with 29R. Therefore, whereas Ar-40/Ar-39 is able only to restrict the duration of volcanism to some 4 Ma, paleomagnetism restricts it to 0.5 Ma. Using some geochemical indicators such as C-13 as proxy, it is suggested that volcanism actually consists of a few shorter events of unequal magnitude. Extrusion rates may be as high as 100 cu km/yr and fissure lengths as long as several 100 km. Such a scenario appears to be at least as successful as others in accounting for most anomalies observed at the KTB. Particularly important are Iridium and other platinum group elements (PGE) profiles, Sr-87/Sr-86, C-13, 0-18, other exotic geochemical signatures, spherules, soot, shocked minerals, selective and stepwise extinctions. The environmental impact of CO2 possibly released during explosive phases of volcanism, and SO2 released during effusive phases, and the ability of volcanism to ensure worldwide distribution of KTB products are now all addressed. In conclusion, the case for a causal link between internal hotspot activity, birth of the Reunion hotspot itself as

  4. Glaucoma Blindness at a Tertiary Eye Care Center.

    PubMed

    Stone, Jordan S; Muir, Kelly W; Stinnett, Sandra S; Rosdahl, Jullia A

    2015-01-01

    Glaucoma is an important cause of irreversible blindness. This study describes the characteristics of a large, diverse group of glaucoma patients and evaluates associations between demographic and clinical characteristics and blindness. Data were gathered via retrospective chart review of patients (N = 1,454) who were seen between July 2007 and July 2010 by glaucoma service providers at Duke Eye Center. Visual acuity and visual field criteria were used to determine whether patients met the criteria for legal blindness. Descriptive and comparative statistical analyses were performed on the glaucoma patients who were not blind (n = 1,258) and those who were blind (n = 196). A subgroup analysis of only those patients with primary open-angle glaucoma was also performed. In this tertiary care population, 13% (n = 196) of glaucoma patients met criteria for legal blindness, nearly one-half of whom (n = 94) were blind from glaucoma, and another one-third of whom (n = 69) had glaucoma-related blindness. The most common glaucoma diagnosis at all levels of vision was primary open-angle glaucoma. A larger proportion of black patients compared with white patients demonstrated vision loss; the odds ratio (OR) for blindness was 2.25 (95% CI, 1.6-3.2) for black patients compared with white patients. The use of systemic antihypertensive medications was higher among patients who were blind compared with patients who were not blind (OR = 2.1; 95% CI, 1.4-3.1). A subgroup analysis including only patients with primary open-angle glaucoma showed similar results for both black race and use of systemic antihypertensive medications. The relationship between use of systemic antihypertensive medications and blindness was not different between black patients and white patients (interaction P = .268). Data were based on chart review, and associations may be confounded by unmeasured factors. Treated systemic hypertension may be correlated with blindness, and the cause cannot be explained solely

  5. Glaucoma Blindness at a Tertiary Eye Care Center

    PubMed Central

    Stone, Jordan S.; Muir, Kelly W.; Stinnett, Sandra S.; Rosdahl, Jullia A.

    2016-01-01

    BACKGROUND Glaucoma is an important cause of irreversible blindness. This study describes the characteristics of a large, diverse group of glaucoma patients and evaluates associations between demographic and clinical characteristics and blindness. METHODS Data were gathered via retrospective chart review of patients (N = 1,454) who were seen between July 2007 and July 2010 by glaucoma service providers at Duke Eye Center. Visual acuity and visual field criteria were used to determine whether patients met the criteria for legal blindness. Descriptive and comparative statistical analyses were performed on the glaucoma patients who were not blind (n = 1,258) and those who were blind (n = 196). A subgroup analysis of only those patients with primary open-angle glaucoma was also performed. RESULTS In this tertiary care population, 13% (n = 196) of glaucoma patients met criteria for legal blindness, nearly one-half of whom (n = 94) were blind from glaucoma, and another one-third of whom (n = 69) had glaucoma-related blindness. The most common glaucoma diagnosis at all levels of vision was primary open-angle glaucoma. A larger proportion of black patients compared with white patients demonstrated vision loss; the odds ratio (OR) for blindness was 2.25 (95% CI, 1.6–3.2) for black patients compared with white patients. The use of systemic antihypertensive medications was higher among patients who were blind compared with patients who were not blind (OR = 2.1; 95% CI, 1.4–3.1). A subgroup analysis including only patients with primary open-angle glaucoma showed similar results for both black race and use of systemic antihypertensive medications. The relationship between use of systemic antihypertensive medications and blindness was not different between black patients and white patients (interaction P = .268). LIMITATIONS Data were based on chart review, and associations may be confounded by unmeasured factors. CONCLUSIONS Treated systemic hypertension may be correlated

  6. Planktonic benthonic foraminiferal ratios: Modern patterns and Tertiary applicability

    Gibson, T.G.

    1989-01-01

    The abundance of planktonic specimens in foraminiferal assemblages was determined in numerous bottom samples from inner neritic to deep oceanic depths along the Atlantic margin of the northeastern United States. The results augment previous studies in other areas that have shown a general increase in percentage of planktonic specimens in total foraminiferal bottom assemblages as water depth increases. The patterns found in this area of complex shelf bathymetry and hydrography illustrate the influence on the planktonic-benthonic percentages of water depth, distance from shore, different water mass properties and downslope movement of tests in high energy areas. The patterns found in the 661 samples from the Atlantic margin were compared with results from 795 stations in the Gulf of Mexico, Pacific Ocean and Red Sea. The relative abundance of planktonic specimens and water depth correlates positively in all open oceanic areas even though taxonomic composition and diversity of the faunas from different areas is variable. The variation of planktonic percentages in bottom samples within most depth intervals is large so that a precise depth determination cannot be made for any given value. However, an approximate upper depth limit for given percentages can be estimated for open ocean environments. A decrease in planktonic percentages is seen in the lower salinity and higher turbidity coastal waters of the Gulf of Maine. Planktonic percentages intermediate between the lower values in the less saline coastal waters and the higher values in the normal open oceanic conditions occur in the transitional area between the Gulf of Maine and the open marine Atlantic Ocean to the east. Similarly lowered values in another area of restricted oceanic circulation occur in the high salinity, clear, but nutrient-poor waters of the Gulf of Aqaba off the Red Sea. A comparison of the similarity of modern planktonic percentage values to those found in earlier Tertiary assemblages was made to

  7. Prevalence of cognitive enhancer use among New Zealand tertiary students.

    PubMed

    Ram, Sanyogita Sanya; Hussainy, Safeera; Henning, Marcus; Jensen, Maree; Russell, Bruce

    2016-05-01

    Cognitive enhancers (CE) such as methylphenidate, amphetamines and modafinil are becoming more commonly used in non-medical situations. This study explored the prevalence and motivations for CE use in a New Zealand university. Students from the Schools of Pharmacy, Nursing, Medicine, Law and Accounting at a university in New Zealand were invited to complete a paper-based questionnaire that elicited their views on the prevalence, reasons for use and attitudes towards use of CEs. Questionnaires were distributed at the end of a third-year lecture (August-October 2012). Reasons for use and attitudes towards use was measured using a 7-point Likert scale from strongly agree (1) to strongly disagree (7). Descriptive and prevalence statistics were calculated. Inferential statistics were generated to explore the overall associations between CE use and how the respondents had first learnt about CEs, and to investigate reasons for CE use. The response fraction was 88.6 % (442/499) and the prevalence of CE use was 6.6% (95% confidence interval 4.5-9.0). Commonly cited reasons for use were to get high [M = 4.43, standard deviation (SD) 2.36], experimentation (M = 4.17, SD 2.36), increase alertness (M = 3.55, SD 2.48), to help concentrate (M = 3.48, SD 2.42), to help stay awake (M = 3.20, SD 2.33), to help study (M = 3.10, SD 2.47) and to concentrate better while studying (M = 3.00, SD 2.43). Use of CEs was uncommon in contrast to the prevalence reported in the USA. The reasons for use also varied depending on which CE was used. Students who use CEs have differing attitudes towards their acceptability, which warrants further research about how these attitudes influence their use and attitudes towards academic performance. [Ram S(S), Hussainy S, Henning M, Jensen M, Russell B. Prevalence of cognitive enhancer use among New Zealand tertiary students. Drug Alcohol Rev 2016;35:245-351]. © 2015 Australasian Professional Society on Alcohol and other Drugs.

  8. Herpes–Zoster Infection in a Tertiary Hospital in Brazil

    PubMed Central

    Antoniolli, Luciana; Azambuja, Aline; Rodrigues, Camila; Borges, Rafael; Goldani, Luciano

    2017-01-01

    Abstract Background herpes zoster (HZ) is a common infection with potential complications requiring hospital care, especially for patients with multiple comorbities. However, there is little information on HZ from hospital registries. Methods we searched for hospital-based records of B02 code (ICD-10) between March 2000 and January 2017 at Hospital de Clínicas de Porto Alegre, a tertiary, university hospital in south Brazil. To avoid misclassifications, we considered clinical evaluation for the diagnosis of cutaneous HZ and postherpetic neuralgia (PHN), ophthalmological evaluation for ophthalmic HZ and the combination of clinical, radiologic and cerebrospinal fluid analysis for HZ meningo-encephalitis (ME). We analyzed conditions associated with immune dysregulation, complications, length of hospital stay, and mortality. Chi-square test and Kaplan-Meier estimator were used for statistical analyses. P < 0.05 was considered statistically significant. Results there were 847 records for this period, of which 801 were confirmed according to our criteria and included in the analysis. Most patients were women (n = 448; 60%), with an average of 48.8 years, standard deviation of 22.2. There were more diagnoses in the inpatients group (74.4%), and fewer in the emergency room (22.4%) and outpatient (3.3%). The median length of hospital stay was 7 days (2-10, P25-P75) when HZ was the main reason for admission. Most patients presented cutaneous HZ (n = 743, 92.8%). There were fewer cases of PHN (6.1%), ophthalmic HZ (7.6%) and ME (4.1%). Seventy percent had some kind of immune dysregulation; more frequently AIDS (31%), use of immunosuppressive agents (18.7%) and malignant disease (16.2%). We followed the subjects for a median of 28.2 (2.8-77.5) months. During this period, there were 105 (13.1%) deaths. Five were related to HZ ME. The 30-day overall mortality rate was 1.5%. There was no statistical difference in cumulative survival (graph 1, P = 0.05) or incidence of

  9. Active Head Lifting from Supine in Early Infancy: An Indicator for Non-Optimal Cognitive Outcome in Late Infancy

    ERIC Educational Resources Information Center

    van Haastert, Ingrid C.; Groenendaal, Floris; van de Waarsenburg, Maria K.; Eijsermans, Maria J. C.; Koopman-Esseboom, Corine; Jongmans, Marian J.; Helders, Paul J. M.; de Vries, Linda S.

    2012-01-01

    Aim: To explore whether active head lifting from supine (AHLS) in early infancy is associated with cognitive outcome in the second year of life. Method: The presence of AHLS was always recorded in the notes of infants admitted to our tertiary neonatal intensive care unit. Random sampling was used to pair infants with AHLS with two comparison…

  10. Impact of long-stay beds on the performance of a tertiary hospital in emergencies

    PubMed Central

    Pazin, Antonio; de Almeida, Edna; Cirilo, Leni Peres; Lourençato, Frederica Montanari; Baptista, Lisandra Maria; Pintyá, José Paulo; Capeli, Ronaldo Dias; da Silva, Sonia Maria Pirani Felix; Wolf, Claudia Maria; Dinardi, Marcelo Marcos; Scarpelini, Sandro; Damasceno, Maria Cecília

    2015-01-01

    ABSTRACT OBJECTIVE To assess the impact of implementing long-stay beds for patients of low complexity and high dependency in small hospitals on the performance of an emergency referral tertiary hospital. METHODS For this longitudinal study, we identified hospitals in three municipalities of a regional department of health covered by tertiary care that supplied 10 long-stay beds each. Patients were transferred to hospitals in those municipalities based on a specific protocol. The outcome of transferred patients was obtained by daily monitoring. Confounding factors were adjusted by Cox logistic and semiparametric regression. RESULTS Between September 1, 2013 and September 30, 2014, 97 patients were transferred, 72.1% male, with a mean age of 60.5 years (SD = 1.9), for which 108 transfers were performed. Of these patients, 41.7% died, 33.3% were discharged, 15.7% returned to tertiary care, and only 9.3% tertiary remained hospitalized until the end of the analysis period. We estimated the Charlson comorbidity index – 0 (n = 28 [25.9%]), 1 (n = 31 [56.5%]) and ≥ 2 (n = 19 [17.5%]) – the only variable that increased the chance of death or return to the tertiary hospital (Odds Ratio = 2.4; 95%CI 1.3;4.4). The length of stay in long-stay beds was 4,253 patient days, which would represent 607 patients at the tertiary hospital, considering the average hospital stay of seven days. The tertiary hospital increased the number of patients treated in 50.0% for Intensive Care, 66.0% for Neurology and 9.3% in total. Patients stayed in long-stay beds mainly in the first 30 (50.0%) and 60 (75.0%) days. CONCLUSIONS Implementing long-stay beds increased the number of patients treated in tertiary care, both in general and in system bottleneck areas such as Neurology and Intensive Care. The Charlson index of comorbidity is associated with the chance of patient death or return to tertiary care, even when adjusted for possible confounding factors. PMID:26603353

  11. Ascertainment bias in dementias: a secondary to tertiary centre analysis in Central Italy and conceptual review.

    PubMed

    Bonanni, L; Bontempo, G; Borrelli, I; Bifolchetti, S; Buongarzone, M P; Carlesi, N; Carolei, A; Ciccocioppo, F; Colangelo, U; Colonna, G; Desiderio, M; Ferretti, S; Fiorelli, L; D'Alessio, O; D'Amico, A; D'Amico, M C; De Lucia, R; Del Re, L; Di Blasio, F; Di Giacomo, R; Di Iorio, A; Di Santo, E; Di Giuseppe, M; Felice, N; Litterio, P; Gabriele, A; Mancino, E; Manzoli, L; Maruotti, V; Mearelli, S; Molino, G; Monaco, D; Nuccetelli, F; Onofrj, M; Perfetti, B; Sacchet, C; Sensi, F; Sensi, S; Sucapane, P; Taylor, J P; Thomas, A; Viola, P; Viola, S; Zito, M; Zhuzhuni, H

    2013-06-01

    Ascertainment bias (AB) indicates a bias of an evaluation centre in estimating the prevalence/incidence of a disease due to the specific expertise of the centre. The aim of our study was to evaluate classification of different types of dementia in new cases appearing in secondary and tertiary centres, in order to evidence possible occurrence of AB in the various (secondary to tertiary) dementia centres. To assess the mechanism of AB, the rates of new cases of the different forms of dementia reported by different centres were compared. The centres involved in the study were 11 hospital-based centres including a tertiary centre, located in the University Department of Clinical Neurology. The tertiary centre is endowed with state-of-the-art diagnostic facilities and its scientific production is prominently focused on dementia with Lewy bodies (DLB) thus suggesting the possible occurrence of a bias. Four main categories of dementia were identified: Alzheimer's disease (AD), DLB, fronto-temporal dementia (FTD), vascular dementia (VaD), with other forms in a category apart. The classification rate of new cases of dementia in the tertiary centre was compared with rates reported by secondary centres and rates of recoding were calculated during a follow-up of 2 years. The study classified 2,042 newly diagnosed cases of dementia in a population of 1,370,000 inhabitants of which 315,000 were older than 65. AD was categorized in 48-52 % of cases, DLB in 25-28 %, FTD in 2-4 % and VaD in 17-28 %. During the 2-year follow-up the diagnosis was re-classified in 40 patients (3 %). The rate of recoding was 5 % in the tertiary centre, 2-8 % in referrals from secondary to tertiary centre, 2-10 % in recodings performed in secondary centres and addressed to tertiary centre. Recoding or percentages of new cases of AD or DLB were not different in the comparison between secondary or between secondary and tertiary centres. FTD and VaD were instead significantly recoded. The results

  12. Migraine disability, healthcare utilization, and expenditures following treatment in a tertiary headache center.

    PubMed

    Freitag, Frederick G; Lyss, Heidi; Nissan, George R

    2013-10-01

    Headache is among the most common disabling pain complaints. While many patients are managed in primary care or referral neurology practices, some patients have refractive situations that necessitate referral to a tertiary headache center. Increasing frequency of headache is strongly associated with increasing disability and workplace absenteeism as well as increased healthcare utilization. Previous studies have demonstrated that headache care in a dedicated tertiary center is associated with a decrease in headache frequency and improvement in other characteristics that persist over extended periods of time. Previous studies have not examined the impact of this treatment on subsequent healthcare utilization and associated expenditures. In this study we examined the changes in healthcare utilization and expenditures as well as the impact on disability and workplace productivity with treatment in a tertiary headache care center that used initial treatment settings of inpatient and outpatient care and considered the difference between those with episodic migraine and those with chronic migraine and its complications. Tertiary care was found to produce positive reductions in disability, healthcare utilization, and expenditures. These results suggest that earlier tertiary-level intervention may avoid the complications of migraine that occur in some patients and the increasing costs and utilization of care associated with higher disability.

  13. Migraine disability, healthcare utilization, and expenditures following treatment in a tertiary headache center

    PubMed Central

    Lyss, Heidi; Nissan, George R.

    2013-01-01

    Headache is among the most common disabling pain complaints. While many patients are managed in primary care or referral neurology practices, some patients have refractive situations that necessitate referral to a tertiary headache center. Increasing frequency of headache is strongly associated with increasing disability and workplace absenteeism as well as increased healthcare utilization. Previous studies have demonstrated that headache care in a dedicated tertiary center is associated with a decrease in headache frequency and improvement in other characteristics that persist over extended periods of time. Previous studies have not examined the impact of this treatment on subsequent healthcare utilization and associated expenditures. In this study we examined the changes in healthcare utilization and expenditures as well as the impact on disability and workplace productivity with treatment in a tertiary headache care center that used initial treatment settings of inpatient and outpatient care and considered the difference between those with episodic migraine and those with chronic migraine and its complications. Tertiary care was found to produce positive reductions in disability, healthcare utilization, and expenditures. These results suggest that earlier tertiary-level intervention may avoid the complications of migraine that occur in some patients and the increasing costs and utilization of care associated with higher disability. PMID:24082410

  14. Thioesterases: A new perspective based on their primary and tertiary structures

    PubMed Central

    Cantu, David C; Chen, Yingfei; Reilly, Peter J

    2010-01-01

    Thioesterases (TEs) are classified into EC 3.1.2.1 through EC 3.1.2.27 based on their activities on different substrates, with many remaining unclassified (EC 3.1.2.–). Analysis of primary and tertiary structures of known TEs casts a new light on this enzyme group. We used strong primary sequence conservation based on experimentally proved proteins as the main criterion, followed by verification with tertiary structure superpositions, mechanisms, and catalytic residue positions, to accurately define TE families. At present, TEs fall into 23 families almost completely unrelated to each other by primary structure. It is assumed that all members of the same family have essentially the same tertiary structure; however, TEs in different families can have markedly different folds and mechanisms. Conversely, the latter sometimes have very similar tertiary structures and catalytic mechanisms despite being only slightly or not at all related by primary structure, indicating that they have common distant ancestors and can be grouped into clans. At present, four clans encompass 12 TE families. The new constantly updated ThYme (Thioester-active enzYmes) database contains TE primary and tertiary structures, classified into families and clans that are different from those currently found in the literature or in other databases. We review all types of TEs, including those cleaving CoA, ACP, glutathione, and other protein molecules, and we discuss their structures, functions, and mechanisms. PMID:20506386

  15. Generic Features of Tertiary Chromatin Structure as Detected in Natural Chromosomes

    PubMed Central

    Müller, Waltraud G.; Rieder, Dietmar; Kreth, Gregor; Cremer, Christoph; Trajanoski, Zlatko; McNally, James G.

    2004-01-01

    Knowledge of tertiary chromatin structure in mammalian interphase chromosomes is largely derived from artificial tandem arrays. In these model systems, light microscope images reveal fibers or beaded fibers after high-density targeting of transactivators to insertional domains spanning several megabases. These images of fibers have lent support to chromonema fiber models of tertiary structure. To assess the relevance of these studies to natural mammalian chromatin, we identified two different ∼400-kb regions on human chromosomes 6 and 22 and then examined light microscope images of interphase tertiary chromatin structure when the regions were transcriptionally active and inactive. When transcriptionally active, these natural chromosomal regions elongated, yielding images characterized by a series of adjacent puncta or “beads”, referred to hereafter as beaded images. These elongated structures required transcription for their maintenance. Thus, despite marked differences in the density and the mode of transactivation, the natural and artificial systems showed similarities, suggesting that beaded images are generic features of transcriptionally active tertiary chromatin. We show here, however, that these images do not necessarily favor chromonema fiber models but can also be explained by a radial-loop model or even a simple nucleosome affinity, random-chain model. Thus, light microscope images of tertiary structure cannot distinguish among competing models, although they do impose key constraints: chromatin must be clustered to yield beaded images and then packaged within each cluster to enable decondensation into adjacent clusters. PMID:15485905

  16. Tertiary stratigraphy and basin evolution, southern Sabah (Malaysian Borneo)

    NASA Astrophysics Data System (ADS)

    Balaguru, Allagu; Nichols, Gary

    2004-08-01

    New mapping and dating of strata in the southern part of the Central Sabah Basin in northern Borneo has made it possible to revise the lithostratigraphy and chronostratigraphy of the area. The recognition in the field of an Early Miocene regional unconformity, which may be equivalent to the Deep Regional Unconformity recognised offshore, has allowed the development of a stratigraphic framework of groups and formations, which correspond to stages in the sedimentary basin development of the area. Below the Early Miocene unconformity lies ophiolitic basement, which is overlain by an accretionary complex of Eocene age and a late Paleogene deep water succession which formed in a fore-arc basin. The late Paleogene deposits underwent syn-depositional deformation, including the development of extensive melanges, all of which can be demonstrated to lie below the unconformity in this area. Some localised limestone deposition occurred during a period of uplift and erosion in the Early Miocene, following which there was an influx of clastic sediments deposited in delta and pro-deltaic environments in the Middle Miocene. These deltaic to shallow marine deposits are now recognised as forming two coarsening-upward successions, mapped as the Tanjong and Kapilit Formations. The total thickness of these two formations in the Central Sabah Basin amounts to 6000 m, only half of the previous estimates, although the total stratigraphic thickness of Cenozoic clastic strata in Sabah may be more than 20,000 m.

  17. Tertiary-amine-containing thermo- and pH-sensitive hydrophilic ABA triblock copolymers: effect of different tertiary amines on thermally induced sol-gel transitions.

    PubMed

    Henn, Daniel M; Wright, Roger A E; Woodcock, Jeremiah W; Hu, Bin; Zhao, Bin

    2014-03-11

    This Article reports on the synthesis of a series of well-defined, tertiary-amine-containing ABA triblock copolymers, composed of a poly(ethylene oxide) (PEO) central block and thermo- and pH-sensitive outer blocks, and the study of the effect of different tertiary amines on thermally induced sol-gel transition temperatures (T(sol-gel)) of their 10 wt % aqueous solutions. The doubly responsive ABA triblock copolymers were prepared from a difunctional PEO macroinitiator by atom transfer radical polymerization of methoxydi(ethylene glycol) methacrylate and ethoxydi(ethylene glycol) methacrylate at a feed molar ratio of 30:70 with ∼5 mol % of either N,N-diethylaminoethyl methacrylate (DEAEMA), N,N-diisopropylaminoethyl methacrylate, or N,N-di(n-butyl)aminoethyl methacrylate. The chain lengths of thermosensitive outer blocks and the molar contents of tertiary amines were very similar for all copolymers. Using rheological measurements, we determined the pH dependences of T(sol-gel) of 10 wt % aqueous solutions of these copolymers in a phosphate buffer. The T(sol-gel) versus pH curves of all polymers exhibited a sigmoidal shape. The T(sol-gel) increased with decreasing pH; the changes were small on both high and low pH sides. At a specific pH, the T(sol-gel) decreased with increasing the hydrophobicity of the tertiary amine, and upon decreasing pH the onset pH value for the T(sol-gel) to begin to increase noticeably was lower for the more hydrophobic tertiary amine-containing copolymer. In addition, we studied the effect of different tertiary amines on the release behavior of FITC-dextran from 10 wt % micellar gels in an acidic medium at 37 and 27 °C. The release profiles for three studied hydrogels at 37 °C were essentially the same, suggesting that the release was dominated by the diffusion of FITC-dextran. At 27 °C, the release was significantly faster for the DEAEMA-containing copolymer, indicating that both diffusion and gel dissolution contributed to the

  18. Determinants of mortality and prolonged hospital stay among dengue patients attending tertiary care hospital: a cross-sectional retrospective analysis

    PubMed Central

    Khan, Amer Hayat; Sarriff, Azmi; Adnan, Azreen Syazril; Khan, Yusra Habib

    2017-01-01

    Objectives Dengue imposes substantial economic, societal and personal burden in terms of hospital stay, morbidity and mortality. Early identification of dengue cases with high propensity of increased hospital stay and death could be of value in isolating patients in need of early interventions. The current study was aimed to determine the significant factors associated with dengue-related prolonged hospitalisation and death. Design Cross-sectional retrospective study. Setting Tertiary care teaching hospital. Participants Patients with confirmed dengue diagnosis were stratified into two categories on the basis of prolonged hospitalisation (≤3 days and >3 days) and mortality (fatal cases and non-fatal cases). Clinico-laboratory characteristics between these categories were compared by using appropriate statistical methods. Results Of 667 patients enrolled, 328 (49.2%) had prolonged hospitalisation. The mean hospital stay was 4.88±2.74 days. Multivariate analysis showed that dengue haemorrhagic fever (OR 2.3), elevated alkaline phosphatase (ALP) (OR 2.3), prolonged prothrombin time (PT) (OR 1.7), activated partial thromboplastin time (aPTT) (OR 1.9) and multiple-organ dysfunctions (OR 2.1) were independently associated with prolonged hospitalisation. Overall case fatality rate was 1.1%. Factors associated with dengue mortality were age >40 years (p=0.004), secondary infection (p=0.040), comorbidities (p<0.05), acute kidney injury (p<0.001), prolonged PT (p=0.022), multiple-organ dysfunctions (p<0.001), haematocrit >20% (p=0.001), rhabdomyolosis (p<0.001) and respiratory failure (p=0.007). Approximately half of the fatal cases in our study had prolonged hospital stay of greater than three days. Conclusions The results underscore the high proportion of dengue patients with prolonged hospital stay. Early identification of factors relating to prolonged hospitalisation and death will have obvious advantages in terms of appropriate decisions about treatment and

  19. Tension-compression-tension tertiary twins in coarse-grained polycrystalline pure magnesium at room temperature

    DOE PAGES

    Yu, Qin; Jiang, Yanyao; Wang, Jian

    2015-04-07

    Using electron backscatter diffraction, the microstructural features of tension–compression–tension (T–C–T) tertiary twins are studied in coarse-grained pure polycrystalline magnesium subjected to monotonic compression along the extrusion direction in ambient air. T–C–T tertiary twins are developed due to the formation of a compression–tension double twin inside a primary tension twin. All the observed T–C–T twin variants are of T iC jT j type. T iC i+1T i+1 (or T iC i–1T i–1) variants are observed more frequently than T iC i+2T i+2 (or T iC i–2T i–2) variants. Moreover, the number of tertiary twin lamellae increases with the applied compressive strain.

  20. Modern Quaternary plant lineages promote diversity through facilitation of ancient Tertiary lineages

    PubMed Central

    Valiente-Banuet, Alfonso; Rumebe, Adolfo Vital; Verdú, Miguel; Callaway, Ragan M.

    2006-01-01

    One of the most important floristic sorting periods to affect modern plant communities occurred during the shift from the wet Tertiary period to the unusually dry Quaternary, when most global deserts developed. During this time, a wave of new plant species emerged, presumably in response to the new climate. Interestingly, most Tertiary species that have been tracked through the fossil record did not disappear but remained relatively abundant despite the development of a much more unfavorable climate for species adapted to moist conditions. Here we find, by integrating paleobotanical, ecological, and phylogenetic analyses, that a large number of ancient Tertiary species in Mediterranean-climate ecosystems appear to have been preserved by the facilitative or “nurse” effects of modern Quaternary species. Our results indicate that these interdependent relationships among plants have played a central role in the preservation of the global biodiversity and provided a mechanism for stabilizing selection and the conservation of ecological traits over evolutionary time scales. PMID:17068126

  1. Manufacture of a combined primary and tertiary mirror for the Large Synoptic Survey Telescope

    NASA Astrophysics Data System (ADS)

    Martin, H. M.; Burge, J. H.; Cuerden, B.; Davison, W. B.; Kingsley, J. S.; Lutz, R. D.; Miller, S. M.; Tuell, M.

    2008-07-01

    The Large Synoptic Survey Telescope uses a unique optomechanical design that places the primary and tertiary mirrors on a single glass substrate. The honeycomb sandwich mirror blank was formed in March 2008 by spin-casting. The surface is currently a paraboloid with a 9.9 m focal length matching the primary. The deeper curve of the tertiary mirror will be produced when the surfaces are generated. Both mirrors will be lapped and polished using stressed laps and other tools on an 8.4 m polishing machine. The highly aspheric primary mirror will be measured through a refractive null lens, and a computer-generated hologram will be used to validate the null lens. The tertiary mirror will be measured through a diffractive null corrector, also validated with a separate hologram. The holograms for the two tests provide alignment references that will be used to make the axes of the two surfaces coincide.

  2. Structure-Function Study of Tertiary Amines as Switchable Polarity Solvents

    SciT

    Aaron D. Wilson; Frederick F. Stewart

    2014-02-01

    A series of tertiary amines have been screened for their function as switchable polarity solvents (SPS). The relative ratios of tertiary amine and carbonate species as well as maximum possible concentration were determined through quantitative 1H and 13C NMR spectroscopy. The viscosities of the polar SPS solutions were measured and ranged from near water in dilute systems through to gel formation at high concentrations. The van't Hoff indices for SPS solutions were measured through freezing point depression studies as a proxy for osmotic pressures. A new form of SPS with an amine : carbonate ratio significantly greater than unity hasmore » been identified. Tertiary amines that function as SPS at ambient pressures appear to be limited to molecules with fewer than 12 carbons. The N,N-dimethyl-n-alkylamine structure has been identified as important to the function of an SPS.« less

  3. Forecasting Tidal Disruption Events for Binary Black Holes with an Outer Tertiary.

    PubMed

    Seto, Naoki; Kyutoku, Koutarou

    2017-04-14

    We discuss the gravitational wave (GW) emission and the orbital evolution of a hierarchical triple system composed of an inner binary black hole (BBH) and an outer tertiary. Depending on the kick velocity at the merger, the merged BBH could tidally disrupt the tertiary. Even though the fraction of BBH mergers accompanied by such disruptions is expected to be much smaller than unity, the existence of a tertiary and its basic parameters (e.g., semimajor axis, projected mass) can be examined for more than 10^{3} BBHs with the follow-on missions to the space GW detector LISA. This allows us to efficiently prescreen the targets for the follow-up searches for the tidal disruption events (TDEs). The TDE probability would be significantly higher for triple systems with aligned orbital- and spin-angular momenta, compared with random configurations.

  4. Delay in presentation to the hospital and factors affecting it in breast cancer patients attending tertiary care center in Central India.

    PubMed

    Thakur, N A; Humne, A Y; Godale, L B

    2015-01-01

    Despite lower incidence of breast cancer in India, the total number of cases and the net mortality is high. To reduce this increasing load of mortality due to breast cancer we need to lay emphasis on early detection and increased use of systemic therapy. Early detection itself depends on early presentation to a health facility; thus, it is important to identify factors affecting delay in a presentation to hospital. To study the clinico-social profile of breast carcinoma patients attending a tertiary care hospital and to study the time lag since detection of lump by women and presentation to the hospital and factors affecting them. A total of 120 primary breast cancer patients visiting a tertiary care hospital over a period of 7 months (August 2010 to February 2011) were taken up for study. A detailed retrospective analysis of patients was done according to planned proforma. Maximum study subjects were in the age group of 41-50 years. Right and left breasts were equally affected. The most common histo-pathological type of breast carcinoma observed was invasive ductal carcinoma (NOS) in 105 (87.50%) cases. Majority of the cases were in stage III or stage II. The median time lag self-detection of lump in the breast by women and presentation to the hospital was 6 months. Women living in a rural area, those with lower socio-economic status and those with older age tend to assess health-care late. Carcinoma of the breast is a common cancer affecting young to middle age group with invasive ductal carcinoma being the most common histological type. Delay in presentation and late stage presentation is a major concern. Hence, proper awareness and screening programmers are needed to identify, inform and educate these categories of women.

  5. Studies in Tertiary stratigraphy of the California Coast Ranges

    Brabb, Earl E.

    1983-01-01

    The correlation of rocks of Paleogene age in California with those in Europe has had a long and complex history that can only be highlighted here. Kleinpell (1938, p. 168-181), in his classic work defining Miocene benthic1 foraminiferal stages of California, attempted to correlate faunas of California with those of western Europe and elsewhere. He pointed out that rocks usually considered lower Miocene in California are probably correlative with those considered Oligocene in Europe. Schenck and Childs (1942) correlated the Vaqueros Sandstone of California with the middle and upper Oligocene of Europe and elsewhere, based on the stratigraphic occurrence of Lepidocyclina. Their correlation was discussed extensively by a number of paleontologists in the same report. Some favored a Miocene age based on similarities of the Vaqueros molluscan fauna with the Burdigalian faunas of Europe, and on the apparent Miocene age of vertebrates from beds below the Vaqueros. Others argued that some of the mollusks in the Vaqueros were similar to those considered Oligocene in Trinidad, and that the percentage of living mollusks in the Vaqueros Sandstone (1-2 percent) was most similar to faunas of Oligocene age. These differences in opinion proved to be irreconcilable in the attempt by the U.S. Committee on Stratigraphy to provide a standard correlation chart for marine Cenozoic formations of western North America (Weaver and others, 1944). Two standards had to be provided, one based largely on mollusks, echinoids, and corals, and the other on benthic foraminifers. This dual classification has persisted almost to the present. The validity of some California Tertiary stages · based largely on benthic foraminifers .has been questioned in recent years. Pierce (1972) and Barron (1976) believed that the Delmontian Stage of Kleinpell (1938), for example, is coeval with the lower and middle part of his Mohnian Stage. Steineck and Gibson (1971), Gibson and Steineck (1972), Schmidt (1975

  6. Tertiary structure-related activity of tick defensin (persulcatusin) in the taiga tick, Ixodes persulcatus.

    PubMed

    Isogai, Emiko; Isogai, Hiroshi; Okumura, Kazuhiko; Hori, Hatsuhiro; Tsuruta, Hiroki; Kurebayashi, Yoichi

    2011-01-01

    Defensins are small cysteine-rich cationic proteins found in both vertebrates and invertebrates constituting the front line of host innate immunity. To examine the importance of the tertiary structure of tick defensin in its antimicrobial activity, we synthesized two types of the peptides with tertiary structure or primary one on basis of the information of the sequence in the defensin originated from the taiga tick, Ixodes persulcatus. Chemically synthesized peptides were used to investigate the activity spectrum against Staphylococcus aureus, Borrelia garinii and flora-associated bacteria. Both synthetic peptides showed antimicrobial activity against S. aureus in short-time killing within 1 h, but they do not show the activity against B. garinii, Stenotrophomonas maltophila and Bacillus spp., which were frequently isolated from the midgut of I. persulcatus. The teriary structure brought more potent activity to S. aureus than primary one in short-time killing. We also examined its antimicrobial activity by evaluation of growth inhibition in the presence of the synthetic peptides. Minimum inhibitory concentration (MIC) was ranged from 1.2 to 5.0 μg/ml in tertiary peptide and from 10 to 40 μg/ml in primary peptide, when 10 strains of S. aureus were used. From the curve of cumulative inhibition rates, MIC50 (MIC which half of the strains showed) to S. aureus is about 1.2 μg/ml in the peptide with tertiary structure and about 10 μg/ml in the linear one. Corynebacterium renale is 10 times or more sensitive to tertiary peptide than primary one. In conclusion, the presence of 3 disulfide bridges, which stabilize the molecule and maintain the tertiary structure, is considered to have an effect on their antimicrobial activities against Gram-positive bacteria such as S. aureus.

  7. Tertiary paediatric emergency department use in children and young people with cerebral palsy.

    PubMed

    Meehan, Elaine; Reid, Susan M; Williams, Katrina; Freed, Gary L; Babl, Franz E; Sewell, Jillian R; Rawicki, Barry; Reddihough, Dinah S

    2015-10-01

    The aim of this study was to describe the pattern of tertiary paediatric emergency department (ED) use in children and young people with cerebral palsy (CP). A retrospective analysis of ED data routinely collected at the two tertiary paediatric hospitals in Victoria, Australia, cross-matched with the Victorian Cerebral Palsy Register. Data pertaining to the ED presentations of 2183 registered individuals born 1993-2008 were obtained. Between 2008 and 2012, 37% (n = 814) of the CP cohort had 3631 tertiary paediatric ED presentations. Overall, 40% (n = 332) of presenters were residing in inner metropolitan Melbourne; 44% (n = 356) in outer Melbourne; and 13% (n = 108) in regional Victoria. Presenters were more likely than non-presenters to be younger, non-ambulant and have epilepsy. In total, 71% of presentations were triaged as Australasian Triage Scale 1-3 (urgent), and 44% resulted in a hospital admission. Disorders of the respiratory, neurological and gastrointestinal systems, and medical device problems were responsible for 72% of presentations. Many of the tertiary paediatric ED presentations in this group were appropriate based on the high admission rate and the large proportion triaged as urgent. However, there is evidence that some families are bypassing local services and travelling long distances to attend the tertiary paediatric ED, even for less urgent complaints that do not require hospital admission. Alternative pathways of care delivery, and strategies to promote the management of common problems experienced by children and young people with CP in non-paediatric EDs or primary care settings, may go some way towards reducing unnecessary tertiary paediatric ED use in this group. © 2015 The Authors. Journal of Paediatrics and Child Health © 2015 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

  8. Superacid synthesized tertiary benzenesulfonamides and benzofuzed sultams act as selective hCA IX inhibitors: toward understanding a new mode of inhibition by tertiary sulfonamides.

    PubMed

    Métayer, Benoît; Martin-Mingot, Agnès; Vullo, Daniella; Supuran, Claudiu T; Thibaudeau, Sébastien

    2013-11-21

    A series of tertiary (fluorinated) benzenesulfonamides was synthesized in superacid HF-SbF5. To circumvent the problem of the in situ iminium ion formation, proved by low temperature NMR experiments, a tandem superacid catalysed cross-coupling reaction was employed to synthesize the benzofuzed sultams analogues. These tertiary benzenesulfonamides were tested as inhibitors of human carbonic anhydrases (hCAs, EC 4.2.1.1). These compounds did not inhibit the widespread off target hCA II isoform and showed strong selectivity toward tumor-associated carbonic anhydrase isoform IX. A dramatic effect of the electronic and structural shape of the inhibitors on selectivity was demonstrated, confirming the non-zinc-bonding mode of inhibition of this class of sulfonamides. This work allowed identifying a highly selective hCA IX inhibitor lead in this series.

  9. Diagenetic trends of a tertiary low-rank coal series

    NASA Astrophysics Data System (ADS)

    Boudou, Jean-Paul; Durand, Bernard; Oudin, Jean-Louis

    1984-10-01

    The Mahakam delta (Kalimantan, Indonesia) coals represent all the evolution stages between freshly-deposited plant/peat material, lignites and bituminous coals. The geochemical techniques used to study this coal series included elemental analysis, extraction of humic compounds, infrared spectroscopy and 13C nuclear magnetic resonance of the total coal. The main mechanisms of early maturation in this series are loss of oxygenated compounds, aromatisation and condensation of the organic matter. These changes, which have already been suggested for other coal series and partially reported for sedimentary organic matter, were confirmed and described in more detail for the Mahakam coal series.

  10. Correlation between the radiological observation of isolated tertiary waves on an esophagram and findings on high-resolution esophageal manometry.

    PubMed

    Halland, M; Ravi, K; Barlow, J; Arora, A

    2016-01-01

    Barium esophagrams are a frequently performed test, and radiological observations about potential abnormal esophageal motility, such as tertiary contractions, are commonly reported. We sought to assess the correlation between tertiary waves, and in particular isolated tertiary waves, on esophagrams and findings on non-synchronous high-resolution esophageal manometry. We retrospectively reviewed reports of esophagrams performed at a tertiary referral center and identified patients in whom tertiary waves were observed and a high-resolution esophageal manometry had been performed. We defined two groups; group 1 was defined as patients with isolated tertiary waves, whereas group 2 had tertiary waves and evidence of achalasia or an obstructing structural abnormality on the esophagram. We collected data on demographics, dysphagia score, associated findings on esophagram, and need for intervention. We reviewed the reports of 2100 esophagrams of which tertiary waves were noted as an isolated abnormality in 92, and in association with achalasia or a structural obstruction in 61. High-resolution manometry was performed in 17 patients in group 1, and five had evidence of a significant esophageal motility disorder and 4 required any intervention. Twenty-one patients in group 2 underwent manometry, and 18 had a significant esophageal motility disorder. An isolated finding of tertiary waves on an esophagram is rarely associated with a significant esophageal motility disorder that requires intervention. All patients with isolated tertiary waves who required intervention had a dysphagia to liquids. Tertiary contractions, in the absence of dysphagia to liquids, indicate no significant esophageal motility disorder. © 2014 International Society for Diseases of the Esophagus.

  11. Tandem catalytic allylic amination and [2,3]-Stevens rearrangement of tertiary amines.

    PubMed

    Soheili, Arash; Tambar, Uttam K

    2011-08-24

    We have developed a catalytic allylic amination involving tertiary aminoesters and allylcarbonates, which is the first example of the use of tertiary amines as intermolecular nucleophiles in metal-catalyzed allylic substitution chemistry. This process is employed in a tandem ammonium ylide generation/[2,3]-rearrangement reaction, which formally represents a palladium-catalyzed Stevens rearrangement. Low catalyst loadings and mild reaction conditions are compatible with an unprecedented substrate scope for the ammonium ylide functionality, and products are generated in high yields and diastereoselectivities. Mechanistic studies suggested the reversible formation of an ammonium intermediate.

  12. Policy and Practice of Tertiary Literacy. Selected Proceedings of the First National Conference on Tertiary Literacy: Research and Practice, Volume 1 (1st, Melbourne, Australia, March 14-16, 1996).

    ERIC Educational Resources Information Center

    Golebiowski, Zofia, Ed.

    This selection of papers from the First Conference on Tertiary Literacy, which examined the role of literacy as a foundation for knowledge acquisition and dissemination that influences the academic success of tertiary students, presents a number of case studies of policy and practice in Australian universities. Keynote addresses included:…

  13. ECTOPIC CUSHING SYNDROME: A 10-YEAR EXPERIENCE FROM A TERTIARY CARE CENTER IN SOUTHERN INDIA.

    PubMed

    Sathyakumar, Samantha; Paul, Thomas Vizhalil; Asha, Hesargatta Shyamsunder; Gnanamuthu, Birla Roy; Paul, M J; Abraham, Deepak Thomas; Rajaratnam, Simon; Thomas, Nihal

    2017-08-01

    Ectopic adrenocorticotropic hormone (ACTH) secretion is a less common cause of Cushing syndrome and is seen in 5 to 10% of cases with endogenous hypercortisolemia. We hereby describe our experience of patients with ectopic ACTH syndrome, who have been managed over the past 10 years at a tertiary care center in Southern India. The inpatient and outpatient records of patients from 2006 to 2015 were retrospectively reviewed. The clinical features, clinical history, biochemical values, imaging features, including radiologic findings and positron emission tomography scans, management, details of follow-up, and outcomes, were documented. We compared the biochemical findings in these patients with 20 consecutive patients with Cushing disease (Cushing syndrome of pituitary origin). A total of 21 patients were studied. The median age at presentation was 34 years (range, 19 to 55 years). Seven patients had thymic carcinoid, 7 had bronchial carcinoid, 3 had lung malignancies, 2 had medullary carcinoma thyroid, 1 patient had a pancreatic neuroendocrine tumor, and 1 patient had an occult source of ACTH. The most common clinical features at presentation were muscle weakness (95%), hyperpigmentation (90%), facial puffiness (76%), easy bruising (61%), edema (57%), and striae (52%). Extensive acne was seen in a large number of patients (43%). Only 3 patients (14%) had central obesity. The median 8 am cortisol was 55.5 μg/dL (range, 3.8 to 131 μg/dL), median 8 am ACTH was 207 pg/mL (range, 31.1 to 703 pg/mL), and the median 24-hour urinary free cortisol was 2,484 μg (range, 248 to 25,438 μg). Basal cortisol and ACTH, as well as midnight cortisol and ACTH level, were markedly higher in patients with ectopic Cushing syndrome as compared to patients with Cushing disease. Twelve of 21 patients had developed life-threatening infections by follow-up. Nine patients had undergone surgical intervention to address the primary tumor. However, only 1 patient exhibited a complete cure on

  14. Deep-sea fan deposition of the lower Tertiary Orca Group, eastern Prince William Sound, Alaska

    Winkler, Gary R.

    1976-01-01

    The Orca Group is a thick, complexly deformed, sparsely fossiliferous sequence of flysch-like sedimentary and tholeiitic volcanic rocks of middle or late Paleocene age that crops out over an area of. roughly 21,000 km2 in the Prince William Sound region and the adjacent Chugach Mountains. The Orca Group also probably underlies a large part of the Gulf of Alaska Tertiary province and the continental shelf south of the outcrop belt; coextensive rocks to the southwest on Kodiak Island are called the Ghost Rocks and Sitkalidak Formations. The Orca Group was pervasively faulted, tightly folded, and metamorphosed regionally to laumontite and prehnite-pumpellyite facies prior to, and perhaps concurrently with, intrusion of early Eocene granodiorite and quartz monzonite plutons. In eastern Prince William Sound, 95% of the Orca sedimentary rocks are interbedded feldspathic and lithofeldspathic sandstone, siltstone, and mudstone turbidites. Lithic components vary widely in abundance and composition, but labile sedimentary and volcanic grains dominate. A widespread yet minor amount of the mudstone is hemipelagic or pelagic, with scattered foraminifers. Pebbly mudstone with rounded clasts of exotic lithologies and locally conglomerate with angular blocks of deformed sandstone identical to the enclosing matrix are interbedded with the turbidites. Thick and thin tabular bodies of altered tholeiitic basalt are locally and regionally conformable with the sedimentary rocks, and constitute 15-20% of Orca outcrops in eastern Prince William Sound. The basalt consists chiefly of pillowed and nonpillowed flows, but also includes minor pillow breccia, tuff, and intrusive rocks. Nonvolcanic turbidites are interbedded with the basalt; lenticular bioclastic limestone, red and green mudstone, chert, and conglomerate locally overlie the basalt, but are supplanted upward by turbidites. From west to east, basalts within the Orca Group become increasingly fragmental and amygdaloidal. Such

  15. Energy, volatile production, and climatic effects of the Chicxulub Cretaceous/Tertiary impact

    NASA Technical Reports Server (NTRS)

    Pope, K. O.; Baines, K. H.; Ocampo, A. C.; Ivanov, B. A.

    1997-01-01

    A comprehensive analysis of volatiles in the Chicxulub impact strongly supports the hypothesis that impact-generated sulfate aerosols caused over a decade of global cooling, acid rain, and disruption of ocean circulation, which contributed to the mass extinction at the Cretaceous/Tertiary (K/T) boundary. The crater size, meteoritic content of the K/T boundary clay, and impact models indicate that the Chicxulub crater was formed by a short period comet or an asteroid impact that released 0.7-3.4 x 10(31) ergs of energy. Impact models and experiments combined with estimates of volatiles in the projectile and target rocks predict that over 200 gigatons (Gt) each of SO2 and water vapor, and over 500 Gt of CO2, were globally distributed in the stratosphere by the impact. Additional volatiles may have been produced on a global or regional scale that formed sulfate aerosols rapidly in cooler parts of the vapor plume, causing an early, intense pulse of sulfuric acid rain. Estimates of the conversion rate of stratospheric SO2 and water vapor to sulfate aerosol, based on volcanic production of sulfate aerosols, coupled with calculations of diffusion, coagulation, and sedimentation, demonstrate that the 200 Gt stratospheric SO2 and water vapor reservoir would produce sulfate aerosols for 12 years. These sulfate aerosols caused a second pulse of acid rain that was global. Radiative transfer modeling of the aerosol clouds demonstrates (1) that if the initial rapid pulse of sulfate aerosols was global, photosynthesis may have been shut down for 6 months and (2) that for the second prolonged aerosol cloud, solar transmission dropped 80% by the end of first year and remained 50% below normal for 9 years. As a result, global average surface temperatures probably dropped between 5 degrees and 31 degrees K, suggesting that global near-freezing conditions may have been reached. Impact-generated CO2 caused less than 1 degree K greenhouse warming and therefore was insignificant compare

  16. Spectrum of Abdominal Aortic Disease in a Tertiary Health Care Setup: MDCT Based Observational Study

    PubMed Central

    Kumar, DG Santosh; Gadabanahalli, Karthik; Kalyanpur, Arjun

    2016-01-01

    Introduction Abdominal aortic disease is an important cause of clinical disability that requires early detection by imaging methods for prompt and effective management. Understanding regional disease pattern and prevalence has a bearing on healthcare management and resource planning. Non-invasive, conclusive imaging strategy plays an important role in the detection of disease. Multi-Detector Computed Tomography (MDCT) with its technological developments provides affordable, accurate and comprehensive imaging solution. Aim To evaluate regional demography of abdominal aortic disease spectrum detected using MDCT imaging data in a tertiary hospital. Materials and Methods A descriptive study was conducted based on MDCT imaging data of patients who were investigated with clinical diagnosis of abdominal aortic disease, from March 2008-2010, over a period of 24 months. Patients were examined with the contrast-enhanced MDCT examination. Morphological diagnosis of the aortic disease was based on changes in relative aortic caliber, luminal irregularity, presence of wall calcification, dissection or thrombus and evidence of major branch occlusion. Patients were categorized into four groups based on imaging findings. MDCT information and associated clinical parameters were examined and correlated to management of patient. Descriptive statistical data, namely mean, standard deviation and frequency of disease were evaluated. Results A total of 90 out of 210 patients (43%) were detected with the abdominal aortic abnormality defined by imaging criteria. Group I, comprising of patients with atherosclerosis –including those with complications, constituted 65.5% of the patients. Group II represented patients with aneurysms (45.5%). Group III, consisting of 32.2% of the patients, contained those with dissections. The rest of the patients, including patients with aorto-arteritis, were classified as group IV. Eight patients with aneurysm and one patient with aorto-arteritis were

  17. Digital model evaluation of the predevelopment flow system of the Tertiary limestone aquifer, Southeast Georgia, Northeast Florida, and South South Carolina

    Krause, Richard E.

    1982-01-01

    A computer model using finite-difference techniques was used successfully to simulate the predevelopment flow regime within the multilayered Tertiary limestone aquifer system in Southeastern Georgia, Northeastern Florida, and Southern South Carolina as part of the U.S. Geological Survey 's Tertiary Limestone Regional Aquifer System analysis. The aquifer, of early Eocene to Miocene age, ranges from thin interbedded clastics and marl in the updip area to massive limestone and dolomite 1,500 feet thick in the downdip area. The aquifer is confined above by Miocene clay beds, and terminates at depth in low-permeability rocks or the saltwater interface. Model-simulated transmissivity of the upper permeable zone ranged from about 1 x 10 super 3 foot squared per day in the updip area and within parts of the Gulf Trough (a series of alinement basins filled by fine clastic in material) to about 1 x 10 super 6 foot squared per day in South Georgia, and area having large secondarily developed solution channels. The model results indicate that only about 540 cubic feet per second of water flowed through the predeveloped system, from the updip highland area of high altitude and in the areas north of Valdosta and southwest of Jacksonville, to discharge along streams in the updip area and diffuse upward leakage in the downdip area near the coast and offshore. (USGS)

  18. Clinical features, microbiology and surgical outcomes of infective endocarditis: a 13-year study from a UK tertiary cardiothoracic referral centre.

    PubMed

    Marks, D J B; Hyams, C; Koo, C Y; Pavlou, M; Robbins, J; Koo, C S; Rodger, G; Huggett, J F; Yap, J; Macrae, M B; Swanton, R H; Zumla, A I; Miller, R F

    2015-03-01

    Infective endocarditis (IE) causes substantial morbidity and mortality. Patient and pathogen profiles, as well as microbiological and operative strategies, continue to evolve. The impact of these changes requires evaluation to inform optimum management and identify individuals at high risk of early mortality. Identification of clinical and microbiological features, and surgical outcomes, among patients presenting to a UK tertiary cardiothoracic centre for surgical management of IE between 1998 and 2010. Retrospective observational cohort study. Clinical, biochemical, microbiological and echocardiographic data were identified from clinical records. Principal outcomes were all-cause 28-day mortality and duration of post-operative admission. Patients (n = 336) were predominantly male (75.0%); median age 52 years (IQR = 41-67). Most cases involved the aortic (56.0%) or mitral (53.9%) valves. Microbiological diagnoses, obtained in 288 (85.7%) patients, included streptococci (45.2%); staphylococci (34.5%); Haemophilus, Actinobacillus, Cardiobacterium, Eikenella, Kingella (HACEK) organisms (3.0%); and fungi (1.8%); 11.3% had polymicrobial infection. Valve replacement in 308 (91.7%) patients included mechanical prostheses (69.8%), xenografts (24.0%) and homografts (6.2%). Early mortality was 12.2%, but fell progressively during the study (P = 0.02), as did median duration of post-operative admission (33.5 to 10.5 days; P = 0.0003). Multivariable analysis showed previous cardiothoracic surgery (OR = 3.85, P = 0.03), neutrophil count (OR = 2.27, P = 0.05), albumin (OR = 0.94, P = 0.04) and urea (OR = 2.63, P < 0.001) predicted early mortality. This study demonstrates reduced post-operative early mortality and duration of hospital admission for IE patients over the past 13 years. Biomarkers (previous cardiothoracic surgery, neutrophil count, albumin and urea), predictive of early post-operative mortality, require prospective evaluation to refine algorithms, further improve

  19. The Effect of Tertiary Teachers' Goal Orientations for Teaching on Their Commitment: The Mediating Role of Teacher Engagement

    ERIC Educational Resources Information Center

    Han, Jiying; Yin, Hongbiao; Wang, Wenlan

    2016-01-01

    This study explored the effect of tertiary teachers' goal orientations for teaching on their commitment, with a particular focus on the mediating role of teacher engagement. The results of a survey of 597 Chinese tertiary teachers indicated that teacher commitment was positively predicted by ability approach, mastery and relational goals, but was…

  20. A New Age Dawning? Australia's New Tertiary Education Quality and Standards Agency Moves towards "Third Stage" Internationalisation

    ERIC Educational Resources Information Center

    Observatory on Borderless Higher Education, 2010

    2010-01-01

    Australia's Minister for Education, Employment and Workplace Relations recently launched a new agency whose primary focus is the protection of the country's tertiary education system. The government is developing the new AUD$57 million (approximately US$51 million) agency, the Tertiary Education Quality and Standards Agency (TEQSA), in response to…

  1. Extent of Information and Communication Technology (ICT) Utilization for Students' Learning in Tertiary Institutions in Ondo State, Nigeria

    ERIC Educational Resources Information Center

    Victor, Akinfolarin Akinwale; Bolanle, Rufai Rukayat

    2017-01-01

    This study investigated the extent of information and communication technology (ICT) utilization for students' learning in Ondo State tertiary institutions. The research design was descriptive survey. The target population comprises of all students in tertiary institutions of learning in Ondo State. A sample of two hundred (200) undergraduate…

  2. Identifying Facilitating Factors and Barriers to Improving Student Retention Rates in Tertiary Teaching Courses: A Systematic Review

    ERIC Educational Resources Information Center

    Bowles, Terence V.; Brindle, Kimberley A.

    2017-01-01

    Factors which impact student retention in tertiary level teaching courses are complex. This study examined facilitating factors and barriers to student retention for students studying education. Due to a limited number of studies, the search was extended to factors impacting students undertaking tertiary education. A systematic review was…

  3. Exploring the Relationship between Goal Orientations for Teaching of Tertiary Teachers and Their Teaching Approaches in China

    ERIC Educational Resources Information Center

    Han, Jiying; Yin, Hongbiao; Wang, Wenlan

    2015-01-01

    This study addresses a paucity of research into teacher motivation in higher education by exploring the relationship between tertiary teachers' goal orientations for teaching and their approaches to teaching in China. A questionnaire gathered responses from 262 Chinese tertiary teachers, and the results showed these teachers reporting higher…

  4. The Spread of Higher Education around the Globe: A Cross- Country Analysis of Gross Tertiary Education Enrollment, 1999-2005

    ERIC Educational Resources Information Center

    Yu, Patricia; Delaney, Jennifer A.

    2016-01-01

    Many nation-states have realized the importance of tertiary education and the world has seen a corollary increase in tertiary education enrollments. Using Berry and Berry's event history model as a framework, this study tests both the internal features of each country and the influence that nation-states have on each other with regard to setting…

  5. Improving Tertiary Student Outcomes in the First Year of Study: What Your Students May Not Tell You

    ERIC Educational Resources Information Center

    Dewart, Bonnie; Rowan, Linda

    2008-01-01

    There has been increased interest in retention and completion with regard to tertiary student outcomes in relation to students' successful completion of their study and what influences this. In New Zealand, the government through the Tertiary Education Commission (TEC) has made it clear that it expects institutions to meet retention and completion…

  6. Assessing Readiness for Integration of Electronic Learning into Business Education Programmes in Tertiary Institutions in Ebonyi State

    ERIC Educational Resources Information Center

    Nwagwu, Lazarus; Azih, Nonye

    2015-01-01

    The study was conducted to assess readiness for integration of electronic learning into business education programmes in tertiary institutions in Ebonyi State. Two research questions and two hypotheses guided the study. The population was 37 business education lecturers and 748 Business Education Students in tertiary institutions that offer…

  7. Tertiary Students' ICT Self-Efficacy Beliefs and the Factors Affecting Their ICT-Use

    ERIC Educational Resources Information Center

    Turel, Vehbi; Calik, Sinan; Doganer, Adem

    2015-01-01

    This study looked at tertiary (i.e. undergraduate /a four-year degree) students' information and communication technology (ICT) self-efficacy beliefs and their level in use of certain common programmes at a newly established (i.e. 2007) university in Turkey in the spring of 2012. The study examined the tertiary students' (a) demographic…

  8. Exploding the Myth: Enhancing the Expression of Faith and Spirituality through the Study of Dance Composition in Christian Tertiary Education

    ERIC Educational Resources Information Center

    Coleman, Lucinda

    2011-01-01

    For dance educators engaged in teaching choreography in Christian tertiary institutes, encouraging students to develop foundational compositional skills whilst exploring personal expression of the Christian faith is undoubtedly a challenging objective. In 2005, a Christian tertiary education provider in South Australia enrolled six female dance…

  9. The Incidence and Management of Conflicts in Secular and Non-Secular Tertiary Institutions in South West Nigeria

    ERIC Educational Resources Information Center

    Ayodele, Joseph Babatola; Adewumi, Joseph Olukayode

    2007-01-01

    This paper compared the incidence and management of conflicts in secular and non-secular tertiary institutions in Nigeria. The sample of this study was made of sixty staff, and two hundred and forty students randomly selected each from two secular and two non-secular tertiary institutions in south western Nigeria. A validated questionnaire was…

  10. The changing profile of eating disorders at a tertiary psychiatric clinic in Hong Kong (1987-2007).

    PubMed

    Lee, Sing; Ng, King Lam; Kwok, Kathleen; Fung, Corina

    2010-05-01

    To examine the clinical profile of Chinese eating disorder patients at a tertiary psychiatric clinic in Hong Kong from 1987 to 2007. Data on 195 consecutive patients were retrieved from a standardized intake interview by an eating disorder specialist. Patients seen between 1987-1997 (n = 67) and 1998-2007 (n = 128) and fat-phobic (n = 76) and nonfat-phobic (n = 39) anorexic patients were compared. Patients were predominantly single (91.8%), female (99.0%), in their early-20s and suffered from anorexia (n = 115; 59.0%) or bulimia (n = 78; 40.0%) nervosa. The number of patients increased twofold across the two periods. Bulimia nervosa became more common while anorexia nervosa exhibited an increasingly fat-phobic pattern. Nonfat-phobic anorexic patients exhibited significantly lower premorbid body weight, less body dissatisfaction, less weight control behavior, and lower EAT-26 scores than fat-phobic anorexic patients. The clinical profile of eating disorders in Hong Kong has increasingly conformed to that of Western countries. 2009 by Wiley Periodicals, Inc.

  11. Help-seeking behavior of patients with mental health problems visiting a tertiary care center in north India.

    PubMed

    Mishra, Nitin; Nagpal, Sajanjiv Singh; Chadda, Rakesh K; Sood, Mamta

    2011-07-01

    Patients with mental health problems in the nonwestern world seek help from a variety of sources, such as the family physicians, psychiatrists, psychologists, traditional faith-healers, or alternative medicine practitioners. Understanding the help-seeking behavior is important from the public health perspective. Two hundred new patients visiting a psychiatric outpatient service at a tertiary care hospital were interviewed on a semi-structured questionnaire for various services contacted by them for their mental health problems. Psychiatrists were the first choice in 45% of the cases followed by nonpsychiatric physicians and religious faith healers. Important reasons to seek help from different sources included easy accessibility, belief in the system, or particular healer and good reputation. Mean duration of treatment varied from 2.35 months with the alternative system practitioners to 16.63 months with the psychiatrists. The mean expenditure per visit to a service was highest for the nonpsychiatric physician and lowest for alternative system practitioners. Patients with mental health problems seek help from psychiatrists, nonpsychiatric physicians, faith healers, alternative system practitioners, and traditional faith healers for multiple reasons. It is important to sensitize various nonpsychiatric physicians with early identification and optimum management of mental disorders.

  12. Biostratigraphic, chronostratigraphic, and stratigraphic sequence analysis of Lower Tertiary marine sediments of Alabama for indicators of sea-level change

    SciT

    Thompson, P.R.; Baum, G.R.

    1991-03-01

    Early Eocene to late Oligocene marine sedimentary units in southwestern Alabama were sampled at closely spaced intervals to derive a precise time-stratigraphic framework and to determine the paleoecological and mineralogical responses to fluctuations in sea level. Paleontologic control consisted of planktonic, smaller and larger benthonic foraminifera, calcareous nannofossils, dinoflagellates, and megafossils. Paleomagnetic reversals were delineated in two boreholes which, when supplemented by strontium isotope dates and the biostratigraphic control, provided a robust in situ chronostratigraphy for the Gulf Coast lower Tertiary. Paleoecologic trends in regression and transgression can be clearly correlated across major regional facies changes. Using the chronostratigraphy developedmore » here, the second-, third-, and fourth-orders of Vail's global sea-level cycles can be recognized and demonstrate the influence of sea-level change on sedimentation. Stratigraphic systems tracts (SSTs) and bounding surfaces in outcrop were determined by lithologic variations and paleoecologic trends, and additionally by gamma logs in the cores. The lower sequence boundary occurs at a contact where an older, relatively fine-grained, deep-water, fossiliferous unit was abruptly succeeded by a coarse-grained, shallow-water, poorly fossiliferous unit. The transgressive surface occurs at the base of a fining- and deepening-upwards unit that was commonly glauconitic and very fossiliferous. Transgression culminated with a pulse of planktonic microfossils in a bed having reduced clastic sedimentation; on the log the surface of maximum starvation was marked by a gamma spike.« less

  13. Relationship between occupational stress and depressive mood among interns and residents in a tertiary hospital, Seoul, Korea.

    PubMed

    Kim, Keon; Lee, Sunhwa; Choi, Yoon Hee

    2015-06-01

    Occupational stress can have a harmful effect on the individual both physically and psychologically. In Korea, occupational stress of physician is rarely demonstrated. Although it is well reported that physicians tend to have a high incidence of minor psychiatric disorders, the magnitude of the problem remains unclear. Interns and residents are thought to be under substantial amount of stress, and tend to have psychiatric disorder. In this paper, we aimed to evaluate the relationship between the occupational stress and depression of residents. The participants of this study were surgical and medical residents in a tertiary hospital in Korea. For measurement of occupational stress, we used an occupational stress scale. In addition, to evaluate the prevalence of depression, we used the Beck Depression Inventory. Female doctors showed higher degree of occupational stress than the males. The interns and chief residents showed higher degree of occupational stress than the other residents. Interestingly, in this study, most of the participants experienced a depressive mood. Compared with the general population, job demand and culture of workplace were high. Occupational stress was the only significant predictor of a depressive mood. Hospital residents experience a high degree of occupational stress leading to a depressed mood due to various risk factors. Therefore, it is essential to recognize the occupational stress of residents early, to encourage positive competition and peer and social support, and to help improve the residents' ability to cope with stress.

  14. Outcome and hospital cost for infants weighing less than 500 grams: a tertiary centre experience in Taiwan.

    PubMed

    Hsieh, Wu-Shiun; Jeng, Suh-Fang; Hung, Yi-Li; Chen, Pau-Chung; Chou, Hung-Chieh; Tsao, Po-Nien

    2007-09-01

    To determine the outcome and hospital cost for infants weighing < or =500 g at a tertiary centre in Taiwan. We retrospectively reviewed the medical records of infants who were born alive with birthweight < or =500 g at the National Taiwan University Hospital from 1997 to 2004. Their outcome and hospital cost were analysed. A total of 168 infants were included for analysis that 146 of them died after compassionate care in the delivery room and 22 received postnatal resuscitation. The infants who received resuscitation were more likely to have higher birthweights, older gestational ages and multiple births compared with those who received compassionate care. After resuscitation, five of the infants died and 17 were admitted to neonatal intensive care unit (NICU) for further management. Subsequently, 12 infants died and five infants survived to discharge. Two infants were discharged against advice and died within days. After exclusion of those receiving compassionate care, the NICU survival rate was 22.7% and the long-term survival rate was 13.6%. The most common early morbidities were respiratory distress syndrome, intraventricular haemorrhage and patent ductus arteriosus, whereas the late morbidities included cholestatic jaundice, retinopathy of prematurity and chronic lung disease. The average total hospital costs for the NICU survivors with birthweight < or =500 g was US $42,411 and the average hospital cost per day was US $350. Exclusive compassionate care was given to the majority of the infants weighing < or =500 g in Taiwan. The survival rate remained low in these marginally viable infants.

  15. Plants with double genomes might have had a better chance to survive the Cretaceous–Tertiary extinction event

    PubMed Central

    Fawcett, Jeffrey A.; Maere, Steven; Van de Peer, Yves

    2009-01-01

    Most flowering plants have been shown to be ancient polyploids that have undergone one or more whole genome duplications early in their evolution. Furthermore, many different plant lineages seem to have experienced an additional, more recent genome duplication. Starting from paralogous genes lying in duplicated segments or identified in large expressed sequence tag collections, we dated these youngest duplication events through penalized likelihood phylogenetic tree inference. We show that a majority of these independent genome duplications are clustered in time and seem to coincide with the Cretaceous–Tertiary (KT) boundary. The KT extinction event is the most recent mass extinction caused by one or more catastrophic events such as a massive asteroid impact and/or increased volcanic activity. These events are believed to have generated global wildfires and dust clouds that cut off sunlight during long periods of time resulting in the extinction of ≈60% of plant species, as well as a majority of animals, including dinosaurs. Recent studies suggest that polyploid species can have a higher adaptability and increased tolerance to different environmental conditions. We propose that polyploidization may have contributed to the survival and propagation of several plant lineages during or following the KT extinction event. Due to advantages such as altered gene expression leading to hybrid vigor and an increased set of genes and alleles available for selection, polyploid plants might have been better able to adapt to the drastically changed environment 65 million years ago. PMID:19325131

  16. Iridium contents in the Late Cretaceous-Early Tertiary clays in relation to the K/T boundary, North Jordan

    NASA Astrophysics Data System (ADS)

    Abboud, Iyad Ahmed

    2016-06-01

    The mineralogy, lithology, and geochemistry of five discrete laminations across the K/T boundary of clayey shale at the Yarmouk River area, Jordan, were examined. There were no marked changes in the mineralogy of the clayey shale within the K/T boundary. This outcrop consists of more than 100 m of Maastrichtian oil shale overlying about 20 m limestone. Marly limestone included many clay laminations from organic and volcanic origins, which are considered an evidence of the K/T boundary through detected iridium anomalies. Any of these particular lamellae range from 2 mm to 5 mm in thickness. Smectite was the predominant clay mineral in smectitic shale laminations. It was located at eight meters above the K/T boundary and includes some anomalous concentrations of iridium and traces of other elements. The analysis of geochemical platinum group at the K/T boundary clays showed anomalous enrichments of iridium, compared with other carbonate rocks as a result of weathering processes of oil shale, or through concentration from weathering of basalt flows, but not pointing to an impact process. The clays in late Maastrichtian have Ir-Sc prevailed anomalies and synchronize with increasing of terrigenous and volcanogenic traced elements. Kaolin, smectite, and volkonskoite were the dominant clay minerals at the K/T boundary with high concentrations of iridium. The concentration levels of iridium in some laminations of the Yarmouk sediments ranged between 1.6 and 7.8 ppb.

  17. Education Policy Analysis, 1999: Resources for Lifelong Learning, Early Childhood Education and Care, Technology in Education, Tertiary Education.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France). Centre for Educational Research and Innovation.

    In its Program for International Student Assessment (PISA), the Organisation for Economic Co-Operation and Development is developing an instrument to compare across countries the quality of outcomes produced by schools. This document explores some issues related to academic achievement. Chapter 1, "Resources for Lifelong Learning: What Might…

  18. West Hackberry Tertiary Project. Quarterly technical progress report, July 1--September 30, 1995

    SciT

    NONE

    The goal of the West Hackberry Tertiary Project is to demonstrate the technical and economic feasibility of combining air injection with the Double Displacement Process for tertiary oil recovery. The Double Displacement Process is the gas displacement of a water invaded oil column for the purpose of recovering oil through gravity drainage. The novel aspect of this project is the use of air as the injection fluid. The target reservoir for the project is the Camerina C-1,2,3 Sand located on the West Flank of West Hackberry Field in Cameron Parish, Louisiana. If successful, this project will demonstrate that the usemore » of air injection in the Double Displacement Process can economically recover oil in reservoirs where tertiary oil recovery is presented uneconomic. During this quarter, the West Hackberry Tertiary Project completed the first ten months of air injection operations. Plots of air injection rates and cumulative air injected are included in this report as attachments. The following events are reviewed in this quarter`s technical progress report: (1) successful workovers on the Gulf Land D Nos. 44, 45 and 51 and the Watkins No. 3; (2) the unsuccessful repair attempt on the Watkins No. 16; (3) gathering of additional bottom hole pressure data; (4) air compressor operations and repairs; and (5) technology transfer activities.« less

  19. The Relationship between Feedback and Change in Tertiary Student Writing in the Disciplines

    ERIC Educational Resources Information Center

    Vardi, Iris

    2008-01-01

    This study examined the relationship between teacher written feedback and change in the disciplinary writing of tertiary students in their final year of undergraduate study. The student texts and teacher written feedback examined arose naturally out of a third year disciplinary-based unit in which each student submitted a text three times over the…

  20. Financing Higher Education in Africa: Makerere, the Quiet Revolution. Tertiary Education Thematic Group Publication Series.

    ERIC Educational Resources Information Center

    Court, David

    This article is part of a series examining the state of higher education in Africa at the end of the 20th century. It tells the dramatic story of how Makerere University in Uganda has addressed the pervasive problem of how to provide quality education at the tertiary level without undue financial dependence on the state. It describes the main…

  1. Factors Influencing Changes in Eating Patterns Among Hong Kong Young Adults Transitioning to Tertiary Education.

    PubMed

    Kwok, Sin Tung; Capra, Sandra; Leveritt, Michael

    2016-05-01

    Transitioning to tertiary education is a significant life course event that has the potential to influence lifelong eating patterns. This study used a theoretic model developed from a life course perspective to examine factors influencing the change of food choices among 31 young adults in Hong Kong after they moved on to tertiary education. Qualitative analysis of transcripts based on the constant comparative method revealed that present life course experiences, especially increased autonomy, and social-environmental factors strongly influenced young adults' present food choices. A model was developed from life course theory and social-ecological theory to reflect the factors that led to change of food choices among participants. The model provides unique insights on food choices of the future adult population. It could also be used as a reference for the development of nutrition education interventions targeting tertiary students as they experience increased autonomy. In conclusion, food choices of young adults on transitioning to tertiary education are strongly influenced by increased autonomy and change of social and environmental factors. © 2016 APJPH.

  2. National Research Priorities for Tertiary Education and Training: 2011-13

    ERIC Educational Resources Information Center

    National Centre for Vocational Education Research (NCVER), 2010

    2010-01-01

    The objective of a national government-funded research program for tertiary education and training is to support the achievement of major social and economic goals. These include increased opportunities for participation in the labour market, improvements in productivity and enhanced social inclusion. In essence, the overarching lens is to…

  3. Deliberate Self-Harm among Children in Tertiary Care Residential Treatment: Prevalence and Correlates

    ERIC Educational Resources Information Center

    Stewart, Shannon L.; Baiden, Philip; Theall-Honey, Laura; den Dunnen, Wendy

    2014-01-01

    Background: Few studies have examined deliberate self-harm (DSH) among children in residential treatment in Canada. Most of the existing studies examined adolescent students or children from pediatric emergency departments. Objectives: The objectives of this study were to examine the prevalence of DSH among children in tertiary care residential…

  4. Graphing in Physics: Processes and Sources of Error in Tertiary Entrance Examinations in Western Australia

    ERIC Educational Resources Information Center

    Forster, Patricia A.

    2004-01-01

    Interpretation and construction of graphs are central to the study of physics and to performance in physics. In this paper, I explore the interpretation and construction processes called upon in questions with a graphical component, in Western Australian Physics Tertiary Entrance Examinations. In addition, I list errors made by students as…

  5. Master Learning: A Way to Manage Tertiary Education in Small Island Jurisdictions

    ERIC Educational Resources Information Center

    Hovgaard, Gestur

    2016-01-01

    As a consequence of globalisation, there is now a general trend among hesitant small island jurisdictions to focus on educational planning in the tertiary sector. The question therefore is how smart solutions adapted to the specific contexts can be developed. This article argues for the need to innovate the societal role of the smaller state…

  6. The Effects of Accelerated Learning on Tertiary Students Learning To Write.

    ERIC Educational Resources Information Center

    Fretz, Barbara L.

    A study investigated how Accelerated Learning (AL), a teaching methodology that purports to increase the quantity and improve the quality of learning, affected tertiary students' knowledge of and skills in writing and their feelings towards writing. AL has its origins in G. Lozanov's "suggestopedia." Believing that formal teaching…

  7. Examination of Factors Predicting Secondary Students' Interest in Tertiary STEM Education

    ERIC Educational Resources Information Center

    Chachashvili-Bolotin, Svetlana; Milner-Bolotin, Marina; Lissitsa, Sabina

    2016-01-01

    Based on the Social Cognitive Career Theory (SCCT), the study aims to investigate factors that predict students' interest in pursuing science, technology, engineering, and mathematics (STEM) fields in tertiary education both in general and in relation to their gender and socio-economic background. The results of the analysis of survey responses of…

  8. Ghostwriters Guaranteeing Grades? The Quality of Online Ghostwriting Services Available to Tertiary Students in Australia

    ERIC Educational Resources Information Center

    Lines, Lisa

    2016-01-01

    Ghostwriting is difficult to detect, it has the potential to be high quality, and universities do not currently have adequate policies in place to police it. Determining the quality of the ghostwriting services available to tertiary students is of vital importance because underestimating the potential for students to use these services to pass…

  9. A Study of First-Year Chemistry Students' Understanding of Solution Concentration at the Tertiary Level

    ERIC Educational Resources Information Center

    de Berg, Kevin

    2012-01-01

    This paper reports on students' understanding of sugar concentration in aqueous solutions presented in two different modes: a visual submicroscopic mode for particles and a verbal mode referring to macroscopic amounts of sugar. One hundred and forty-five tertiary college students studying some form of first-year chemistry participated in the…

  10. Rhodium-catalyzed kinetic resolution of tertiary homoallyl alcohols via stereoselective carbon-carbon bond cleavage.

    PubMed

    Shintani, Ryo; Takatsu, Keishi; Hayashi, Tamio

    2008-03-20

    A nonenzymatic kinetic resolution of tertiary homoallyl alcohols has been developed through a rhodium-catalyzed retro-allylation reaction under simple conditions. Selectivity factors of up to 12 have been achieved by employing (R)-H8-binap as the ligand, and the reaction can be conducted on a preparative scale.

  11. Professional Development for E-Learning: Researching a Strategy for New Zealand's Tertiary Education Sector

    ERIC Educational Resources Information Center

    Shephard, Kerry; Mansvelt, Juliana; Stein, Sarah; Suddaby, Gordon; Harris, Irene; O'Hara, Duncan

    2011-01-01

    This collaborative research project devised a framework to support professional development for e-learning within New Zealand's diverse and integrated tertiary education sector. The research was supported by New Zealand's Ministry of Education. The research included reviews of developments in the United Kingdom, Australia and New Zealand and a…

  12. About Student's Media Use for Learning in Tertiary Education Influence Factors and Structures of Usage Behavior

    ERIC Educational Resources Information Center

    Grosch, Michael

    2014-01-01

    The rise of the web 2.0 led to dramatic changes in media usage behavior of students in tertiary education. Services such as Google and Facebook are most accepted amongst students not only in pastime but also for learning. A representative survey was made at Karlsruhe Institute of Technology (KIT). About 1,400 students were asked 150 questions to…

  13. Strategies for Teaching Business Education Students in Nigerian Tertiary Institutions for Cooperate Governance

    ERIC Educational Resources Information Center

    Obiete, Innocent Anthony; Nwazor, Joseph Chukwudi; Ifeoma, Vin-Mbah Fidelia

    2015-01-01

    In recent time, graduates from the nation's tertiary institution of learning most especially the business education graduates have been plagued by the inability to get jobs in corporate industries and companies in Nigeria. Many authors and researchers have related this problem to the quality of training received by these graduates while in school…

  14. An Integrated Skills Approach Using Feature Movies in EFL at Tertiary Level

    ERIC Educational Resources Information Center

    Tuncay, Hidayet

    2014-01-01

    This paper presents the results of a case study based on an integrated skills approach using feature movies (DVDs) in EFL syllabi at the tertiary level. 100 students took part in the study and the data was collected through a three - section survey questionnaire: demographic items, 18 likert scale questions and an open-ended question. The data…

  15. First Inversion: A Rationale for Implementing the "Flipped Approach" in Tertiary Music Courses

    ERIC Educational Resources Information Center

    Grant, Catherine

    2013-01-01

    For several reasons, current models of tertiary education seem unviable. A shifting educational landscape with rising student numbers, an increasingly diverse student cohort, and high levels of student disengagement have led to concerns about the continued relevance of "traditional" teaching and learning methods. At the same time, the…

  16. Teacher Effects on Student Attrition and Performance in Mass-Market Tertiary Education

    ERIC Educational Resources Information Center

    Foster, Gigi

    2010-01-01

    Tertiary education is now accessible even to those who appear unlikely "ex ante" to succeed in jobs requiring post-high school education. Institutions that have broadened access to their programs must rely on two things to protect the quality of the degrees they award: selection mechanisms operating during students' tenure, and effective…

  17. Pre-University Prepared Students: A Programme for Facilitating the Transition from Secondary to Tertiary Education

    ERIC Educational Resources Information Center

    McPhail, Ruth

    2015-01-01

    The expectations of first-year students are becoming more widely researched and understood. How to realign perceptions and prepare students for the transition from secondary school to tertiary education is less well considered. This paper presents an account of a pre-university preparation programme embedded in the senior years of secondary…

  18. Accountability and Transparency in the Financial Management of Nigerian Tertiary Educational Institutions: An Overview

    ERIC Educational Resources Information Center

    Adebisi, Ademola

    2013-01-01

    It is a widely acknowledged fact that public tertiary educational institutions in Nigeria are not adequately funded. This has contributed to the slide in the giving and receiving standards of education in the country. However, as paltry as the financial receipts of the institutions are, it has been argued that, if the funds are transparently…

  19. Standards to Assure Quality in Tertiary Education: The Case of Tanzania

    ERIC Educational Resources Information Center

    Manyaga, Timothy

    2008-01-01

    Purpose: The purpose of this paper is to provide information on development of standards in Tanzania which may be of help to training providers in other countries as they seek to improve the quality and standards of their provision. Design/methodology/approach: The need to provide quality assured tertiary qualifications in Tanzania to win both…

  20. Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors.

    PubMed

    Moore, Keith P; Zhu, Hong; Rajapakse, Hemaka A; McGaughey, Georgia B; Colussi, Dennis; Price, Eric A; Sankaranarayanan, Sethu; Simon, Adam J; Pudvah, Nicole T; Hochman, Jerome H; Allison, Timothy; Munshi, Sanjeev K; Graham, Samuel L; Vacca, Joseph P; Nantermet, Philippe G

    2007-11-01

    This letter describes replacements for the P3 amide moiety present in previously reported tertiary carbinamine macrolactones. Although P-gp efflux issues associated with these amide-macrolactones were solved and full brain penetration was measured in one case, potency was compromised in the process.