Sample records for early unclassified polyarthritis

  1. Chronic polyarthritis as isolated manifestation of toxocariasis.

    PubMed

    Viola, Gabriela R; Giacomin, Maria Fernanda A; França, Camila M P; Sallum, Adriana M E; Jacob, Cristina M A; Silva, Clovis A

    2016-01-01

    Human toxocariasis is a parasitic zoonosis mainly caused by Toxocara canis or Toxocara cati and is acquired by ingestion of the parasite's embryonated eggs. Arthralgia and/or arthritis were reported in up to 17% of the cases, generally with acute duration (less than 6 weeks). However, to our knowledge, chronic polyarthritis, as the isolated presentation of Toxocara infection, was not reported. One of the 5809 patients that was followed up at our service (0.017%) had chronic polyarthritis as the single manifestation of toxocariasis and was described herein. A 3-year-old girl was referred to our service with severe painful chronic polyarthritis for a period longer than 10 weeks and morning stiffness of 30min. Dog contact exposure history in the recreational areas of neighborhood was reported. Her exams showed high levels of eosinophils in peripheral blood (29%), bone marrow aspirate revealed marked eosinophilia (32%) and Toxocara enzyme-linked immunosorbent assay (Elisa) was positive (1:1280). She was treated with paracetamol (40mg/kg/day) and thiabendazole (25mg/kg/day) for 10 days, and all manifestations reduced. After eight months of follow-up, she was on clinical and laboratorial remission. In conclusion, we described a case of chronic polyarthritis, as isolated manifestation of toxocariasis, mimicking juvenile idiopathic arthritis and leukemia. Importantly, this zoonosis should be considered in patients with arthritis and eosinophilia. Copyright © 2014 Elsevier Editora Ltda. All rights reserved.

  2. Angioimmunoblastic T-Cell Lymphoma with Polyarthritis Resembling Rheumatoid Arthritis.

    PubMed

    Yachoui, Ralph; Farooq, Nouman; Amos, Jonathan V; Shaw, Gene R

    2016-12-01

    Angioimmunoblastic T-cell lymphoma (AITL) is a rare subtype of peripheral T-cell lymphoma (PTCL). AITL typically presents with lymphadenopathy, fever, rash, hepatosplenomegaly, and rarely polyarthritis. We report the case of a 50-year-old female who presented with lymphadenopathy, rash, and symmetric polyarthritis. She was later diagnosed with AITL and was treated with chemotherapy with resolution of arthritis. AITL should be suspected in paitents presenting with rheumatoid-like arthritis and diffuse lymphadenopathy. © 2016 Marshfield Clinic.

  3. An abrupt onset of seropositive polyarthritis with prominent distal tenosynovitis concomitant with bronochiolitis obliterans organizing pneumonia (BOOP): consideration of the relationship with RS3PE syndrome.

    PubMed

    Kato, Takashi; Ubara, Yoshifumi; Sawa, Naoki; Tagami, Tetsuo; Katori, Hideyuki; Takemoto, Fumi; Hara, Shigeko; Takaichi, Kenmei

    2004-02-01

    A 64-year-old Japanese woman with a two-week history of polyarthralgia and persistent cough was diagnosed as seropositive polyarthritis and fulfilled the criteria of early rheumatoid arthritis (RA). In addition, inflammatory pitting edema of the distal extremities was apparent, suggestive of the remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome. A number of investigations including hand MRI, bone scintigraphy and HLA typing supported a diagnosis of RS3PE syndrome rather than RA. Chest computed tomography revealed concomitant evidence of bronchiolitis obliterans organizing pneumonia (BOOP). Treatment with 30 mg of prednisolone daily immediately ameliorated the polyarthritis and the BOOP. Seropositive polyarthritis with distal pitting edema may be categorized as both RA and the RS3PE syndrome.

  4. Epidemic polyarthritis and Ross River virus disease.

    PubMed

    Fraser, J R

    1986-08-01

    Ross River virus is a mosquito-transmitted alphavirus indigenous to Australia, Papua New Guinea and nearby islands, which recently appeared in other western and central South Pacific islands. Human infection can be manifest by varied constitutional disturbances, rash and rheumatic symptoms, known in Australia as epidemic polyarthritis and broadly similar to certain alphavirus diseases in other regions. Although usually short-lived, the rash can persist for 5 months. Rheumatic effects involve synovial joints, tendon and ligaments, and can continue or recur in peripheral joints and tissues as long as 6 years, though gradually improving without destructive changes. At different times, the disease can closely simulate rubella and other virus diseases, Henoch-Schönlein syndrome, rheumatoid and other chronic rheumatic diseases. Diagnosis rests upon geography, specific serology and judicious interpretation of clinical and supportive laboratory data. Skin and synovial lesions are characterized by infiltration of mononuclear cells. Their pathogenesis most likely depends on the reaction of these cells with persistent foci of virus disseminated during the early viraemic phase of infection.

  5. Acute onset polyarthritis in older people: Is it RS3PE syndrome?

    PubMed

    Salam, Abdul; Henry, Rafik; Sheeran, Tom

    2008-08-29

    Remitting Seronegative Symmetrical Synovitis with Pitting oedema syndrome, a rare inflammatory arthritis, commonly affects people in the older age group. It can present as an acute onset polyarthritis with associated pitting oedema of the extremities. Patients show excellent response to low dose steroids with complete and sustained remissions. It can also be a paraneoplastic manifestation of an underlying occult malignancy, hence thorough clinical evaluation is warranted.We discuss a case of Remitting Seronegative Symmetrical Synovitis with pitting oedema syndrome where the patient presented with acute onset polyarthritis and pitting oedema of the extremities without an underlying systemic cause. Patient showed dramatic response to low dose steroids.

  6. Acute onset polyarthritis in older people: Is it RS3PE syndrome?

    PubMed Central

    Salam, Abdul; Henry, Rafik; Sheeran, Tom

    2008-01-01

    Remitting Seronegative Symmetrical Synovitis with Pitting oedema syndrome, a rare inflammatory arthritis, commonly affects people in the older age group. It can present as an acute onset polyarthritis with associated pitting oedema of the extremities. Patients show excellent response to low dose steroids with complete and sustained remissions. It can also be a paraneoplastic manifestation of an underlying occult malignancy, hence thorough clinical evaluation is warranted. We discuss a case of Remitting Seronegative Symmetrical Synovitis with pitting oedema syndrome where the patient presented with acute onset polyarthritis and pitting oedema of the extremities without an underlying systemic cause. Patient showed dramatic response to low dose steroids. PMID:18759976

  7. [RS3PE syndrome: an acute edematous polyarthritis of the elderly with variable prognosis].

    PubMed

    Beyne-Rauzy, O; Revel, V; Desfossez, V; Bousquet, E; Nourhashemi, F; Adoue, D

    2001-06-01

    The RS3PE syndrome or subacute edematous polyarthritis of the elderly remains a doubtful entity. We report three cases that exhibited different courses: complete recovery, definite rheumatoid polyarthritis, and chronicity as a sign of myelodysplasic disease. These three different courses raise the question of whether RS3PE is a disease or a syndrome. Actually, the use of the term RS3PE syndrome should be restricted to cases with a favorable outcome. Definitive diagnosis thus cannot be reached before complete recovery.

  8. 7 CFR 51.1003 - Unclassified.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Standards for Persian (Tahiti) Limes Unclassified § 51.1003 Unclassified. “Unclassified” consists of Persian limes which have not been classified in accordance with any of the foregoing grades. The term...

  9. 7 CFR 51.3743 - Unclassified.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Standards for Grades of Honey Dew and Honey Ball Type Melons Unclassified § 51.3743 Unclassified. “Unclassified” consists of melons which have not been classified in accordance with any of the foregoing grades...

  10. 7 CFR 51.3743 - Unclassified.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Standards for Grades of Honey Dew and Honey Ball Type Melons Unclassified § 51.3743 Unclassified. “Unclassified” consists of melons which have not been classified in accordance with any of the foregoing grades...

  11. Acute polyarthritis in a young patient caused by meningococcal and parvovirus B19 infections: a case report and review of the literature.

    PubMed

    Lavoipierre, Virginie; Dellyes, Anna; Aubry, Camille; Zandotti, Christine; Lafforgue, Pierre; Parola, Philippe; Lagier, Jean-Christophe

    2016-12-20

    Meningococcal infection is a multifaceted disease including acute polyarthritis. This presentation should be known by clinicians in order to prevent delay in treatment. We report what we believe to be the first case of an association of parvovirus B19 and meningococcal polyarthritis in a young adult. A 19-year-old Caucasian woman presented to our hospital with fever, intense leg pain, and a transient rash. A physical examination showed asymmetric polyarthritis and no neurological abnormalities. A parvovirus B19 polymerase chain reaction performed using a blood sample and knee fluid aspirate came back positive, but serology was negative for immunoglobulin M and positive for immunoglobulin G. A blood culture was positive for serotype C meningococcus; a polymerase chain reaction performed for Neisseria meningitidis was positive in joint fluid but negative in blood samples (performed after antibiotic treatment had begun). Our patient was treated with ceftriaxone for 15 days, associated with analgesic therapy. Hydroxychloroquine treatment was introduced 5 months after the onset of polyarthritis because of persisting inflammatory arthralgia. To the best of our knowledge, this is the first case report of polyarthritis caused by concomitant meningococcal and parvovirus B19 infections. This unusual presentation of meningococcal disease may have resulted from the persistent parvovirus B19 infection. Our experience with this case illustrates the need for a systematic approach to the diagnosis of febrile acute polyarthritis. Only long-term follow-up will reveal if this infectious polyarthritis will evolve towards an autoimmune rheumatism.

  12. Polyarthritis and bone lesions complicating traumatic pancreatitis in two children.

    PubMed Central

    Goluboff, N.; Cram, R.; Ramgotra, B.; Singh, A.; Wilkinson, G. W.

    1978-01-01

    The association of bone lesions, polyarthritis and cutaneous nodules with pancreatic disease is being recognized and reported more frequently. In adults all forms of pancreatitis and carcinoma of the pancreas have been involved, but in the few children described these complications have been associated with acute traumatic pancreatitis. This paper describes two cases of acute traumatic pancreatitis in which polyarthritis and limb pains were noted after 2 to 3 weeks. In one child osteolytic lesions and periostitis were seen on roentgenograms 7 weeks after the onset of pancreatitis. In the other child minor roentgenographic changes were not seen until 5 months after the onset; however, bone scans showed clear-cut abnormalities after 1 month. Almost complete resolution could be expected within a year. Serum lipase and amylase concentrations remained elevated during the acute illness. Disseminated fat necrosis is apparently related to the excess amounts of circulating lipase. Images FIG. 1 FIG. 2 FIG. 3 FIG. 4 FIG. 5 FIG. 6 PMID:647564

  13. Unclassified Data Export from the Containment Database

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gaylord, Jessie M.; Myers, K. B. L.

    2016-08-03

    The attached dataset is an unclassified subset of data copied from the CDB for release to a wider audience. It includes only the clearly unclassified columns from each of the tables in the CDB, and only the rows related to announced tests. Also included is a glossary that lists each of the tables and columns included in the export with its definition, historical labels, unit of measure, and reference information. Our objective is to make this unclassified dataset available for querying on an unclassified server through a repeatable process.

  14. Imaging diagnosis--necrotizing meningomyelitis and polyarthritis.

    PubMed

    Parry, Andrew T; Penning, Victoria A; Smith, Ken C; Kenny, Patrick J; Lamb, Christopher R

    2009-01-01

    A vaccinated 2-year-old female neutered Weimaraner had bilateral pelvic limb ataxia that progressed over 12 h. The dog became nonambulatory, with signs of pain on palpation of the lumbar spine. The dog also developed multiple joint effusions. On magnetic resonance (MR) imaging, there was a diffuse, asymmetric T2-hyperintensity in the thoracolumbar spinal cord which was characterized by contrast enhancement. Lumbar cerebrospinal fluid (CSF) analysis had an elevated white blood cell count and protein. On the basis of MR images and CSF analysis, a presumptive diagnosis of diffuse myelitis was made. The dog became paraplegic and was euthanized. Postmortem examination confirmed the presence of myelitis with vasculitis and nonerosive polyarthritis.

  15. N-terminal pro-brain-type natriuretic peptide (NT-pro-BNP) and mortality risk in early inflammatory polyarthritis: results from the Norfolk Arthritis Registry (NOAR)

    PubMed Central

    Mirjafari, Hoda; Welsh, Paul; Verstappen, Suzanne M M; Wilson, Paddy; Marshall, Tarnya; Edlin, Helena; Bunn, Diane; Chipping, Jacqueline; Lunt, Mark; Symmons, Deborah P M; Sattar, Naveed; Bruce, Ian N

    2014-01-01

    Background We measured N-terminal pro-brain natriuretic peptide (NT-pro-BNP), a marker of cardiac dysfunction, in an inception cohort with early inflammatory polyarthritis (IP) and assessed its association with disease phenotype, cardiovascular disease (CVD), all-cause and CVD related mortality. Methods Subjects with early IP were recruited to the Norfolk Arthritis Register from January 2000 to December 2008 and followed up to death or until March 2010 including any data from the national death register. The associations of baseline NT-pro-BNP with IP related factors and CVD were assessed by linear regression. Cox proportional hazards models examined the independent association of baseline NT-pro-BNP with all-cause and CVD mortality. Results We studied 960 early IP subjects; 163 (17%) had prior CVD. 373 (39%) patients had a baseline NT-pro-BNP levels ≥100 pg/ml. NT-pro-BNP was associated with age, female gender, HAQ score, CRP, current smoking, history of hypertension, prior CVD and the presence of carotid plaque. 92 (10%) IP subjects died including 31 (3%) from CVD. In an age and gender adjusted analysis, having a raised NT-pro-BNP level (≥100 pg/ml) was associated with both all-cause and CVD mortality (adjusted HR (95% CI) 2.36 (1.42 to 3.94) and 3.40 (1.28 to 9.03), respectively). These findings were robust to adjustment for conventional CVD risk factors and prevalent CVD. Conclusions In early IP patients, elevated NT-pro-BNP is related to HAQ and CRP and predicts all-cause and CVD mortality independently of conventional CVD risk factors. Further study is required to identify whether NT-pro-BNP may be clinically useful in targeting intensive interventions to IP patients at greatest risk of CVD. PMID:23511225

  16. 10 CFR 1017.12 - Prohibitions on identifying Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Nuclear Information. 1017.12 Section 1017.12 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.12 Prohibitions on identifying Unclassified...

  17. 10 CFR 1017.12 - Prohibitions on identifying Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Nuclear Information. 1017.12 Section 1017.12 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.12 Prohibitions on identifying Unclassified...

  18. 10 CFR 1017.12 - Prohibitions on identifying Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Nuclear Information. 1017.12 Section 1017.12 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.12 Prohibitions on identifying Unclassified...

  19. 10 CFR 1017.12 - Prohibitions on identifying Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Nuclear Information. 1017.12 Section 1017.12 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.12 Prohibitions on identifying Unclassified...

  20. 10 CFR 1017.12 - Prohibitions on identifying Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Nuclear Information. 1017.12 Section 1017.12 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.12 Prohibitions on identifying Unclassified...

  1. UNCLASSIFIED TPBAR RELEASES, INCLUDING TRITIUM TTQP-1-091 Rev 14

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gruel, Robert L.; Love, Edward F.; Thornhill, Cheryl K.

    This document provides a listing of unclassified tritium release values that should be assumed for unclassified analysis. Much of the information is brought forth from the related documents listed in Section 5.0 to provide a single-source listing of unclassified release values. This information has been updated based on current design analysis and available experimental data.

  2. Risk factors for oral methotrexate failure in patients with inflammatory polyarthritis: results from a UK prospective cohort study.

    PubMed

    Bluett, James; Sergeant, Jamie C; MacGregor, Alex J; Chipping, Jacqueline R; Marshall, Tarnya; Symmons, Deborah P M; Verstappen, Suzanne M M

    2018-03-20

    Oral methotrexate (MTX) is the first-line therapy for patients with rheumatoid arthritis (RA). However, approximately one quarter of patients discontinue MTX within 12 months. MTX failure, defined as MTX cessation or the addition of another anti-rheumatic drug, is usually due adverse event(s) and/or inefficacy. The aims of this study were to evaluate the rate and predictors of oral MTX failure. Subjects were recruited from the Norfolk Arthritis Register (NOAR), a primary care-based inception cohort of patients with early inflammatory polyarthritis (IP). Subjects were eligible if they commenced MTX as their first DMARD and were recruited between 2000 and 2008. Patient-reported reasons for MTX failure were recorded and categorised as adverse event, inefficacy or other. The addition of a second DMARD during the study period was categorised as failure due to inefficacy. Cox proportional hazards regression models were used to assess potential predictors of MTX failure, accounting for competing risks. A total of 431 patients were eligible. The probability of patients remaining on MTX at 2 years was 82%. Competing risk analysis revealed that earlier MTX failure due to inefficacy was associated with rheumatoid factor (RF) positivity, younger age at symptom onset and higher baseline disease activity (DAS-28). MTX cessation due to an adverse event was less likely in the RF-positive cohort. RF-positive inflammatory polyarthritis patients who are younger with higher baseline disease activity have an increased risk of MTX failure due to inefficacy. Such patients may require combination therapy as a first-line treatment.

  3. 10 CFR 1017.16 - Unclassified Controlled Nuclear Information markings on documents or material.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Unclassified Controlled Nuclear Information markings on...) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Review of a Document or Material for Unclassified Controlled Nuclear Information § 1017.16 Unclassified Controlled Nuclear Information markings on...

  4. 10 CFR 1017.16 - Unclassified Controlled Nuclear Information markings on documents or material.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Unclassified Controlled Nuclear Information markings on...) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Review of a Document or Material for Unclassified Controlled Nuclear Information § 1017.16 Unclassified Controlled Nuclear Information markings on...

  5. 10 CFR 1017.16 - Unclassified Controlled Nuclear Information markings on documents or material.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Unclassified Controlled Nuclear Information markings on...) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Review of a Document or Material for Unclassified Controlled Nuclear Information § 1017.16 Unclassified Controlled Nuclear Information markings on...

  6. 10 CFR 1017.16 - Unclassified Controlled Nuclear Information markings on documents or material.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Unclassified Controlled Nuclear Information markings on...) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Review of a Document or Material for Unclassified Controlled Nuclear Information § 1017.16 Unclassified Controlled Nuclear Information markings on...

  7. 10 CFR 1017.16 - Unclassified Controlled Nuclear Information markings on documents or material.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Unclassified Controlled Nuclear Information markings on...) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Review of a Document or Material for Unclassified Controlled Nuclear Information § 1017.16 Unclassified Controlled Nuclear Information markings on...

  8. 48 CFR 1252.239-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... unclassified information technology resources. 1252.239-70 Section 1252.239-70 Federal Acquisition Regulations... of Provisions and Clauses 1252.239-70 Security requirements for unclassified information technology... Unclassified Information Technology Resources (APR 2005) (a) The Contractor shall be responsible for...

  9. 48 CFR 1252.239-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... unclassified information technology resources. 1252.239-70 Section 1252.239-70 Federal Acquisition Regulations... of Provisions and Clauses 1252.239-70 Security requirements for unclassified information technology... Unclassified Information Technology Resources (APR 2005) (a) The Contractor shall be responsible for...

  10. 48 CFR 1252.239-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... unclassified information technology resources. 1252.239-70 Section 1252.239-70 Federal Acquisition Regulations... of Provisions and Clauses 1252.239-70 Security requirements for unclassified information technology... Unclassified Information Technology Resources (APR 2005) (a) The Contractor shall be responsible for...

  11. 48 CFR 1252.239-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... unclassified information technology resources. 1252.239-70 Section 1252.239-70 Federal Acquisition Regulations... of Provisions and Clauses 1252.239-70 Security requirements for unclassified information technology... Unclassified Information Technology Resources (APR 2005) (a) The Contractor shall be responsible for...

  12. 48 CFR 1252.239-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... unclassified information technology resources. 1252.239-70 Section 1252.239-70 Federal Acquisition Regulations... of Provisions and Clauses 1252.239-70 Security requirements for unclassified information technology... Unclassified Information Technology Resources (APR 2005) (a) The Contractor shall be responsible for...

  13. Forces Mobilization Model (FORCEMOB): Unclassified Training Tutorial

    DTIC Science & Technology

    2015-08-01

    I N S T I T U T E F O R D E F E N S E A N A L Y S E S Forces Mobilization Model (FORCEMOB): Unclassified Training Tutorial James S. Thomason...Graham for review of this document and Mrs. Amberlee Mabe -Stanberry for editing and production assistance. Copyright Notice © 2015 Institute for...N S E A N A L Y S E S Forces Mobilization Model (FORCEMOB): Unclassified Training Tutorial James S. Thomason, Project Leader Robert J. Atwell

  14. 48 CFR 3052.204-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... unclassified information technology resources. 3052.204-70 Section 3052.204-70 Federal Acquisition Regulations... for unclassified information technology resources. As prescribed in (HSAR) 48 CFR 3004.470-3, insert a clause substantially the same as follows: Security Requirements for Unclassified Information Technology...

  15. 48 CFR 3052.204-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... unclassified information technology resources. 3052.204-70 Section 3052.204-70 Federal Acquisition Regulations... for unclassified information technology resources. As prescribed in (HSAR) 48 CFR 3004.470-3, insert a clause substantially the same as follows: Security Requirements for Unclassified Information Technology...

  16. 48 CFR 3052.204-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... unclassified information technology resources. 3052.204-70 Section 3052.204-70 Federal Acquisition Regulations... for unclassified information technology resources. As prescribed in (HSAR) 48 CFR 3004.470-3, insert a clause substantially the same as follows: Security Requirements for Unclassified Information Technology...

  17. 22 CFR 125.2 - Exports of unclassified technical data.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., visual or documentary disclosure of technical data by U.S. persons to foreign persons. A license is... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Exports of unclassified technical data. 125.2... THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.2 Exports of unclassified technical...

  18. 22 CFR 125.2 - Exports of unclassified technical data.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., visual or documentary disclosure of technical data by U.S. persons to foreign persons. A license is... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Exports of unclassified technical data. 125.2... THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.2 Exports of unclassified technical...

  19. 22 CFR 125.2 - Exports of unclassified technical data.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., visual or documentary disclosure of technical data by U.S. persons to foreign persons. A license is... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Exports of unclassified technical data. 125.2... THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.2 Exports of unclassified technical...

  20. 22 CFR 125.2 - Exports of unclassified technical data.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., visual or documentary disclosure of technical data by U.S. persons to foreign persons. A license is... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Exports of unclassified technical data. 125.2... THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.2 Exports of unclassified technical...

  1. Chronic polyarthritis as the first manifestation of childhood systemic polyarteritis nodosa.

    PubMed

    Novak, Glaucia Vanessa; Hayashi, Koken; Sampa, Kohei; Okumura, Yosuke; Ferreira, Gabriela Ribeiro Viola; Silva, Clovis Artur

    2017-01-01

    Arthritis has been reported as an acute pattern, generally evanescent with oligoarthritis, mostly affecting knees and ankles in childhood systemic polyarteritis nodosa. However, chronic polyarthritis with morning stiffness mimicking juvenile idiopathic arthritis has not been reported. We describe the case of a 4-year old girl who had additive and chronic polyarthritis with edema, tenderness, pain on motion and morning stiffness for 2 months. After 45 days, she also presented painful subcutaneous nodules and erythematous-violaceous lesions in the extensor region of upper and lower limbs. She was admitted to university hospital due to high fever, malaise, myalgia, anorexia, loss of weight (1kg), painful skin lesions and severe functional disability. She was bedridden by chronic polyarthritis with limitation on motion. Systolic and diastolic blood pressures were greater than 95th percentile for height. Urine protein/creatinine ratio was 0.39g/day, and immunological tests were negative. Anti-streptolysin O was 1,687UI/mL. Skin biopsy revealed necrotizing vasculitis in medium- and small-sized vessels compatible with polyarteritis nodosa. Therefore, we had the diagnosis of systemic polyarteritis nodosa. Prednisone 2mg/kg/day was administered with complete resolution of skin lesions and arthritis, and improvement of proteinuria (0.26g/day) after 15 days. The diagnosis of childhood systemic polyarteritis nodosa should be considered for patients with chronic polyarthritis associated to cutaneous vasculitis triggered by streptococcal infection. RESUMO Na poliarterite nodosa sistêmica pediátrica, a artrite caracteriza-se pelo padrão agudo, geralmente evanescente, com oligoartrite, e afeta principalmente joelhos e tornozelos. No entanto, a poliartrite crônica com rigidez matinal e simulando artrite idiopática juvenil ainda não foi relatada. Descrevemos o caso de uma menina de 4 anos que apresentou poliartrite crônica aditiva com edema, dor à palpação e movimento, e

  2. Proteomic Analysis of Synovial Fluid Obtained From a Dog Diagnosed With Idiopathic Immune-Mediated Polyarthritis.

    PubMed

    Tan, Wei Miao; Lau, Seng Fong; Ajat, Mokrish; Mansor, Rozaihan; Abd Rani, Puteri Azaziah Megat; Rahmad, Norasfaliza Binti

    2017-03-01

    This case study is to report the proteins detected by proteomic analysis of synovial fluid from a dog diagnosed with idiopathic immune-mediated polyarthritis, and to compare it with healthy dogs. Synovial fluid was collected via arthrocentesis from a dog diagnosed with immune-mediated polyarthritis. Protein precipitation was performed on the synovial fluid, followed by isoelectric focusing and 2-dimensional gel electrophoresis. The spots on the 2-dimensional gels were analyzed using MALDI-TOF/MS. The results were then analyzed against the MASCOT database. The results from the proteomic analysis revealed an abundance of several types of immunoglobulins together with the presence of complement C4b-binding protein alpha chain. Actin and keratin were also among the proteins detected. Proteomic studies, facilitate a better understanding of the different levels of proteins expressed during disease activity. Potential disease biomarkers can aid in the diagnosis of disease, as well as help in monitoring treatment efficacy and providing prognosis for the patient. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. 10 CFR 1017.8 - Subject areas eligible to be Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Nuclear Information. 1017.8 Section 1017.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.8 Subject areas eligible to be Unclassified...

  4. 10 CFR 1017.8 - Subject areas eligible to be Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Nuclear Information. 1017.8 Section 1017.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.8 Subject areas eligible to be Unclassified...

  5. 10 CFR 1017.8 - Subject areas eligible to be Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Nuclear Information. 1017.8 Section 1017.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.8 Subject areas eligible to be Unclassified...

  6. 10 CFR 1017.8 - Subject areas eligible to be Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Nuclear Information. 1017.8 Section 1017.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.8 Subject areas eligible to be Unclassified...

  7. 10 CFR 1017.8 - Subject areas eligible to be Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Nuclear Information. 1017.8 Section 1017.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.8 Subject areas eligible to be Unclassified...

  8. The effect of an educational programme consisting of group and individual arthritis education for patients with polyarthritis--a randomised controlled trial.

    PubMed

    Grønning, Kjersti; Skomsvoll, Johan F; Rannestad, Toril; Steinsbekk, Aslak

    2012-07-01

    The aim of this study was to investigate the effect of an educational programme for patients with polyarthritis compared to usual care. Patients with rheumatoid arthritis, psoriatic arthritis and unspecified polyarthritis were randomised to the intervention (n=71) or usual care (n=70). The intervention consisted of three group educational sessions followed by one individual educational session. The primary outcomes were a patient's global well-being and arthritis self-efficacy. Secondary outcomes were patient activation, physical and psychological health status, educational needs and disease activity. After four months the intervention group had significantly better global well-being, 95% CI (2.3-14.1), p=0.01, and self-efficacy, 95% CI (0.2-8.1), p=0.04, than the control group. There were also trends for improved disease activity, and a statistically significant improvement in patient activation and pain in the intervention group. This patient educational programme consisting of group sessions and nurse-delivered individual education has statistically significant benefits for global well-being and maintaining a level of self-efficacy in managing other symptoms in patients with polyarthritis. This educational programme allows patients to learn from each other in addition to addressing individual educational needs. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  9. Neutrophilic dermatosis resembling pyoderma gangrenosum in a dog with polyarthritis.

    PubMed

    Bardagí, M; Lloret, A; Fondati, A; Ferrer, L

    2007-04-01

    This report describes a case of neutrophilic dermatosis in a dog, with a number of clinical and pathological similarities to human pyoderma gangrenosum. A seven-year-old, female German shepherd dog with a history of non-erosive idiopathic polyarthritis was presented with severe facial swelling, bilateral erosivoulcerative lesions on the muzzle and multiple, eroded, dermal-subcutaneous nodules on the cranial trunk. Histopathological examination of skin biopsies revealed a necrotising neutrophilic dermatitis. No infectious agents could be detected using specific stains, immunohistochemistry, serology and bacterial aerobic, anaerobic or fungal cultures. A sterile neutrophilic dermatosis resembling human pyoderma gangrenosum was presumptively diagnosed, and the patient showed an excellent response to treatment with prednisone and ciclosporin.

  10. Unclassified congenital deformities of the external ear.

    PubMed

    Vathulya, Madhubari

    2018-01-01

    Congenital ear deformities are a common entity. They are found in isolation or as a part of syndrome in patients. They may involve the external, middle or inner ear or in any of these combinations. Three patients of different ages presented with deformities including mirror image duplication of the superior auricle, unclassified deformities of ear lobule (wavy lobule) and deformity of superior auricle with unclassified variety of lateral ear pit. This article highlights that there are further cases of ear deformities that are noticed in the general population who come for cosmetic correction, and hence, there is a need for further modifying the classification of ear deformities.

  11. 14 CFR 1274.937 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... information technology resources. 1274.937 Section 1274.937 Aeronautics and Space NATIONAL AERONAUTICS AND... Conditions § 1274.937 Security requirements for unclassified information technology resources. Security Requirements for Unclassified Information Technology Resources July 2002 (a) The Recipient shall be responsible...

  12. 14 CFR 1274.937 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... information technology resources. 1274.937 Section 1274.937 Aeronautics and Space NATIONAL AERONAUTICS AND... Conditions § 1274.937 Security requirements for unclassified information technology resources. Security Requirements for Unclassified Information Technology Resources July 2002 (a) The Recipient shall be responsible...

  13. 14 CFR 1274.937 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... information technology resources. 1274.937 Section 1274.937 Aeronautics and Space NATIONAL AERONAUTICS AND... Conditions § 1274.937 Security requirements for unclassified information technology resources. Security Requirements for Unclassified Information Technology Resources July 2002 (a) The Recipient shall be responsible...

  14. 14 CFR 1274.937 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... information technology resources. 1274.937 Section 1274.937 Aeronautics and Space NATIONAL AERONAUTICS AND... Conditions § 1274.937 Security requirements for unclassified information technology resources. Security Requirements for Unclassified Information Technology Resources July 2002 (a) The Recipient shall be responsible...

  15. Heterogeneity in Unclassifiable Interstitial Lung Disease: A Systematic Review and Meta-Analysis.

    PubMed

    Guler, Sabina A; Ellison, Kina; Algamdi, Mohmmed; Collard, Harold R; Ryerson, Christopher J

    2018-05-20

    Accurate diagnosis of interstitial lung disease (ILD) is necessary to identify the most appropriate management strategy and to inform prognosis. Many patients cannot be provided a confident diagnosis despite an exhaustive search for potential etiologies and review in a multidisciplinary conference; and are consequently labelled with unclassifiable ILD. to systematically review and meta-analyse previous studies reporting on the diagnostic criteria, prevalence, clinical features, and outcome of unclassifiable ILD. Medline, Embase, and the Cochrane Central Register of Controlled Trials databases were systematically searched for all studies related to unclassifiable ILD published before September 1, 2017. Two authors independently screened each citation for eligibility criteria, serially reviewing the title, abstract, and full-text manuscript, and then abstracted data pertaining to the study objectives from eligible studies. Articles were stratified by risk of selection bias, whether the publication stated that patients were reviewed in a multidisciplinary discussion, and by the frequency of surgical lung biopsy. Meta-analyses and meta-regression were performed to calculate the pooled prevalence of unclassifiable ILD within an ILD population and within specific subgroups to identify reasons for across-study heterogeneity. The search identified 10130 unique citations, 313 articles underwent full-text review, and eligibility criteria were met in 88 articles. Twenty-two studies were deemed low risk of selection bias, including 1060 patients with unclassifiable ILD from a total of 10174 patients with ILD. The terminology and definition of unclassifiable ILD varied substantially across publications, with inconsistent diagnostic criteria and evaluation processes. The prevalence of unclassifiable ILD was 11.9% (95% confidence interval 8.5% to 15.6%), with lower prevalence in centers that reported use of a formal multidisciplinary discussion of cases (9.5% vs. 14.5%). Four

  16. Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis.

    PubMed

    Lacey, Derek; Hickey, Peter; Arhatari, Benedicta D; O'Reilly, Lorraine A; Rohrbeck, Leona; Kiriazis, Helen; Du, Xiao-Jun; Bouillet, Philippe

    2015-08-04

    Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are chronic inflammatory diseases that together affect 2-3% of the population. RA and AS predominantly involve joints, but heart disease is also a common feature in RA and AS patients. Here we have studied a new spontaneous mutation that causes severe polyarthritis in bone phenotype spontaneous mutation 1 (BPSM1) mice. In addition to joint destruction, mutant mice also develop aortic root aneurism and aorto-mitral valve disease that can be fatal depending on the genetic background. The cause of the disease is the spontaneous insertion of a retrotransposon into the 3' untranslated region (3'UTR) of the tumor necrosis factor (TNF), which triggers its strong overexpression in myeloid cells. We found that several members of a family of RNA-binding, CCCH-containing zinc-finger proteins control TNF expression through its 3'UTR, and we identified a previously unidentified regulatory element in the UTR. The disease in BPSM1 mice is independent of the adaptive immune system and does not appear to involve inflammatory cytokines other than TNF. To our knowledge, this is the first animal model showing both polyarthritis and heart disease as a direct result of TNF deregulation. These results emphasize the therapeutic potential of anti-TNF drugs for the treatment of heart valve disease and identify potential therapeutic targets to control TNF expression and inflammation.

  17. First report of an unclassified Demodex mite causing demodicosis in a Venezuelan dog.

    PubMed

    Alvarez, L; Medina, O C; García, M-E; García, H

    2007-09-01

    For the first time in Venezuela, a case of canine demodicosis apparently caused by a simultaneous infection with an unclassified Demodex and Demodex canis has been observed. The most severely affected area of the dog involved, a 3-month-old male Doberman Pinscher, was the head, particularly the peri-orbital skin. Skin samples of the affected areas were taken and evaluated by both light and scanning electron microscopy. The mites of the unclassified Demodex were smaller than those of D. canis and appeared relatively stout. In the skin scrapings, D. canis outnumbered the unclassified Demodex by a ratio of 30:1, making it unclear if the unclassified Demodex is pathogenic to dogs. A combination of superficial and deep skin scrapings, from a suspected case of demodicosis, may help to reveal other infestations of the unclassified Demodex that would otherwise be masked by concurrent infections with D. canis.

  18. 75 FR 68675 - Controlled Unclassified Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ... Order 13556 of November 4, 2010 Controlled Unclassified Information By the authority vested in me as...: Section 1. Purpose. This order establishes an open and uniform program for managing information that... Government-wide policies, excluding information that is classified under Executive Order 13526 of December 29...

  19. 10 CFR 1017.11 - Information exempt from being Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Nuclear Information. 1017.11 Section 1017.11 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.11 Information exempt from being...

  20. 10 CFR 1017.11 - Information exempt from being Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Nuclear Information. 1017.11 Section 1017.11 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.11 Information exempt from being...

  1. 10 CFR 1017.11 - Information exempt from being Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Nuclear Information. 1017.11 Section 1017.11 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.11 Information exempt from being...

  2. 10 CFR 1017.11 - Information exempt from being Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Nuclear Information. 1017.11 Section 1017.11 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.11 Information exempt from being...

  3. 10 CFR 1017.11 - Information exempt from being Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Nuclear Information. 1017.11 Section 1017.11 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.11 Information exempt from being...

  4. A serial study of anticardiolipin antibody and antimitochondrial antibody type M5 in a patient with polyarthritis and polymyositis.

    PubMed

    Keane, A; Woods, R; Foley-Nolan, D; Roden, D; Coughlan, R; Barry, C

    1989-04-01

    A 22-year-old female presented with polyarthritis and subsequent polymyositis. Initially, she had moderately high levels of anticardiolipin (aCl) and antimitochondrial antibody (AMA) type M5. Following corticosteroid therapy, the anticardiolipin antibody rapidly fell to background levels but reappeared with the onset of two significant clinical events.

  5. 48 CFR 1804.470 - Security requirements for unclassified information technology (IT) resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Security requirements for unclassified information technology (IT) resources. 1804.470 Section 1804.470 Federal Acquisition Regulations... Classified Information Within Industry 1804.470 Security requirements for unclassified information technology...

  6. 48 CFR 1804.470 - Security requirements for unclassified information technology (IT) resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Security requirements for unclassified information technology (IT) resources. 1804.470 Section 1804.470 Federal Acquisition Regulations... Classified Information Within Industry 1804.470 Security requirements for unclassified information technology...

  7. 48 CFR 1804.470 - Security requirements for unclassified information technology (IT) resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Security requirements for unclassified information technology (IT) resources. 1804.470 Section 1804.470 Federal Acquisition Regulations... Classified Information Within Industry 1804.470 Security requirements for unclassified information technology...

  8. 48 CFR 1804.470 - Security requirements for unclassified information technology (IT) resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Security requirements for unclassified information technology (IT) resources. 1804.470 Section 1804.470 Federal Acquisition Regulations... Classified Information Within Industry 1804.470 Security requirements for unclassified information technology...

  9. 48 CFR 1804.470 - Security requirements for unclassified information technology (IT) resources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Security requirements for unclassified information technology (IT) resources. 1804.470 Section 1804.470 Federal Acquisition Regulations... Classified Information Within Industry 1804.470 Security requirements for unclassified information technology...

  10. 48 CFR 1852.204-76 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... unclassified information technology resources. 1852.204-76 Section 1852.204-76 Federal Acquisition Regulations... information technology resources. As prescribed in 1804.470-4(a), insert the following clause: SECURITY REQUIREMENTS FOR UNCLASSIFIED INFORMATION TECHNOLOGY RESOURCES (MONTH YEAR) (a) The contractor shall protect...

  11. 48 CFR 552.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Unclassified Information Technology Resources. 552.239-71 Section 552.239-71 Federal Acquisition Regulations... Text of Provisions and Clauses 552.239-71 Security Requirements for Unclassified Information Technology... Information Technology Resources (JAN 2012) (a) General. The Contractor shall be responsible for information...

  12. 48 CFR 652.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Unclassified Information Technology Resources. 652.239-71 Section 652.239-71 Federal Acquisition Regulations... Provisions and Clauses 652.239-71 Security Requirements for Unclassified Information Technology Resources. As... Technology Resources (SEP 2007) (a) General. The Contractor shall be responsible for information technology...

  13. 48 CFR 552.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Unclassified Information Technology Resources. 552.239-71 Section 552.239-71 Federal Acquisition Regulations... Text of Provisions and Clauses 552.239-71 Security Requirements for Unclassified Information Technology... Information Technology Resources (JAN 2012) (a) General. The Contractor shall be responsible for information...

  14. 48 CFR 652.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Unclassified Information Technology Resources. 652.239-71 Section 652.239-71 Federal Acquisition Regulations... Provisions and Clauses 652.239-71 Security Requirements for Unclassified Information Technology Resources. As... Technology Resources (SEP 2007) (a) General. The Contractor shall be responsible for information technology...

  15. 48 CFR 552.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Unclassified Information Technology Resources. 552.239-71 Section 552.239-71 Federal Acquisition Regulations... Text of Provisions and Clauses 552.239-71 Security Requirements for Unclassified Information Technology... Information Technology Resources (JAN 2012) (a) General. The Contractor shall be responsible for information...

  16. 48 CFR 652.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Unclassified Information Technology Resources. 652.239-71 Section 652.239-71 Federal Acquisition Regulations... Provisions and Clauses 652.239-71 Security Requirements for Unclassified Information Technology Resources. As... Technology Resources (SEP 2007) (a) General. The Contractor shall be responsible for information technology...

  17. 48 CFR 552.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Unclassified Information Technology Resources. 552.239-71 Section 552.239-71 Federal Acquisition Regulations... Text of Provisions and Clauses 552.239-71 Security Requirements for Unclassified Information Technology... Information Technology Resources (JUN 2011) (a) General. The Contractor shall be responsible for information...

  18. 48 CFR 652.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Unclassified Information Technology Resources. 652.239-71 Section 652.239-71 Federal Acquisition Regulations... Provisions and Clauses 652.239-71 Security Requirements for Unclassified Information Technology Resources. As... Technology Resources (SEP 2007) (a) General. The Contractor shall be responsible for information technology...

  19. 48 CFR 1852.204-76 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... unclassified information technology resources. 1852.204-76 Section 1852.204-76 Federal Acquisition Regulations... information technology resources. As prescribed in 1804.470-4(a), insert the following clause: Security Requirements for Unclassified Information Technology Resources (MONTH YEAR) (a) The contractor shall protect...

  20. 48 CFR 1852.204-76 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... unclassified information technology resources. 1852.204-76 Section 1852.204-76 Federal Acquisition Regulations... information technology resources. As prescribed in 1804.470-4(a), insert the following clause: Security Requirements for Unclassified Information Technology Resources (MONTH YEAR) (a) The contractor shall protect...

  1. 48 CFR 1852.204-76 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... unclassified information technology resources. 1852.204-76 Section 1852.204-76 Federal Acquisition Regulations... information technology resources. As prescribed in 1804.470-4(a), insert the following clause: Security Requirements for Unclassified Information Technology Resources (MONTH YEAR) (a) The contractor shall protect...

  2. 48 CFR 652.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Unclassified Information Technology Resources. 652.239-71 Section 652.239-71 Federal Acquisition Regulations... Provisions and Clauses 652.239-71 Security Requirements for Unclassified Information Technology Resources. As... Technology Resources (SEP 2007) (a) General. The Contractor shall be responsible for information technology...

  3. 14 CFR § 1274.937 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... information technology resources. § 1274.937 Section § 1274.937 Aeronautics and Space NATIONAL AERONAUTICS... Conditions § 1274.937 Security requirements for unclassified information technology resources. Security Requirements for Unclassified Information Technology Resources July 2002 (a) The Recipient shall be responsible...

  4. Insufficient colostrum ingestion is a risk factor for polyarthritis and/or phlegmon in hand-reared reticulated giraffes (Giraffa camelopardalis reticulata): 7 cases (2003-2012).

    PubMed

    Kido, Nobuhide; Nagakura, Kasumi; Itabashi, Masanori; Ono, Kaori; Dan, Mayuko; Matsumoto, Rei; Omiya, Tomoko

    2014-08-01

    Seven reticulated giraffes were hand-reared at Nogeyama Zoological Gardens, because the dam had agalactia. Six of the 7 calves exhibited polyarthritis and/or phlegmon in the lower legs. However, the cause of the disorder was unclear. The present study reviewed the clinical records of the 7 giraffes, including the type and amount of colostrum ingested during the first 72 hr. The disorder involved the fetlocks and carpal and tarsal joints in 6 of the 7 calves within an average of 8 days of birth. The average amount of fed bovine or powdered colostrum was 0-2.4 l in the first 24 hr and 2.0-6.2 l during the first 72 hr. Insufficient colostrum quantity might be a factor in polyarthritis and/or phlegmon.

  5. Pancreatitis, panniculitis and polyarthritis (PPP-) syndrome caused by post-pancreatitis pseudocyst with mesenteric fistula. Diagnosis and successful surgical treatment. Case report and review of literature.

    PubMed

    Dieker, Wulf; Derer, Johannes; Henzler, Thomas; Schneider, Alexander; Rückert, Felix; Wilhelm, Torsten J; Krüger, Bernd

    2017-01-01

    Pancreatitis, panniculitis and polyarthritis syndrome is a very rare extra-pancreatic complication of pancreatic diseases. While in most cases this syndrome is caused by acute or chronic pancreatitis, we report a case of a 62-year-old man presenting with extensive intraosseous fat necrosis, polyarthritis and panniculitis caused by a post-pancreatitis pseudocyst with a fistula to the superior mesenteric vein and extremely high blood levels of lipase. This became symptomatic 2.5 years after an episode of acute pancreatitis and as in most cases abdominal symptoms were absent. Treatment by surgical resection of the pancreatic head with the pseudocyst and mesenteric fistula led to complete remission of all symptoms. A review of the literature revealed that all publications are limited to case reports. Most authors hypothesize that an unspecific damage can cause a secretion of pancreatic enzymes to the bloodstream leading to a systemic lipolysis and fat tissue necrosis, especially of subcutaneous tissue, bone marrow, inducing panniculitis, polyarthritis and osteonecrosis. Even if caused by an acute pancreatitis abdominal symptoms are often mild or absent in most cases leading to misdiagnosis and poor prognosis. While symptomatic treatment with NSAR and cortisone showed poor to moderate response, causal treatment can be successful depending on the underlying pancreatic disease. Copyright © 2017. Published by Elsevier Ltd.

  6. T-regulatory cells-Triumph of perseverance: The Crafoord Prize for Polyarthritis in 2017.

    PubMed

    Wollheim, Frank A

    2018-02-01

    The Crafoord Prize in Polyarthritis ranks as one of the most prestigious prizes and can be awarded only if the Royal Swedish Academy of Sciences decides the likelihood of prize worthy progress in the field, and at most every 4th year. This has happened only four times since 1982. This year the 5th Laureates were Shimon Sakaguchi, Fred Ramsdell, and Alexander Rudensky with the motivation "for their discoveries relating to regulatory T cells, which counteract harmful immune reactions in arthritis and other autoimmune diseases". Here I review the history of their contributions and its impact in rheumatology. Copyright © 2018. Published by Elsevier Inc.

  7. Insufficient Colostrum Ingestion is a Risk Factor for Polyarthritis and/or Phlegmon in Hand-Reared Reticulated Giraffes (Giraffa camelopardalis reticulata): 7 Cases (2003–2012)

    PubMed Central

    KIDO, Nobuhide; NAGAKURA, Kasumi; ITABASHI, Masanori; ONO, Kaori; DAN, Mayuko; MATSUMOTO, Rei; OMIYA, Tomoko

    2014-01-01

    ABSTRACT Seven reticulated giraffes were hand-reared at Nogeyama Zoological Gardens, because the dam had agalactia. Six of the 7 calves exhibited polyarthritis and/or phlegmon in the lower legs. However, the cause of the disorder was unclear. The present study reviewed the clinical records of the 7 giraffes, including the type and amount of colostrum ingested during the first 72 hr. The disorder involved the fetlocks and carpal and tarsal joints in 6 of the 7 calves within an average of 8 days of birth. The average amount of fed bovine or powdered colostrum was 0–2.4 l in the first 24 hr and 2.0–6.2 l during the first 72 hr. Insufficient colostrum quantity might be a factor in polyarthritis and/or phlegmon. PMID:24758869

  8. Acute generalized exanthematous pustulosis and polyarthritis associated with a novel CARD14 mutation.

    PubMed

    Podlipnik, Sebastian; Castellanos-Moreira, Raul; Florez-Enrich, Helena; Arostegui, Juan Ignacio; Mascaró, José Manuel

    2018-02-01

    Acute generalised exanthematous pustulosis (AGEP) is a rare toxicoderma characterised by an acute onset rash, with many sterile pustules on the surface, high fever and increased acute phase reactants. We report the case of a patient who presented to the dermatology department with an AGEP and polyarthritis, in which a novel CARD14 mutation was identified. The pathophysiological mechanism of AGEP remains unclear, although mutations in the IL36RN gene have been identified in a small subset of AGEP patients. Similarly, mutations in the CARD14 gene have been linked to pustular types of psoriasis and familiar cases of pityriasis rubra pilaris; however, there are no reports associating mutations in the CARD14 gene with AGEP. © 2017 The Australasian College of Dermatologists.

  9. A survey of unclassified axial-flow-compressor literature

    NASA Technical Reports Server (NTRS)

    Herzig, Howard Z; Hansen, Arthur G

    1955-01-01

    A survey of unclassified axial-flow-compressor literature is presented in the form of brief reviews of the methods, results, and conclusions of selected reports. The reports are organized into several main categories with subdivisions, and frequent references are made within the individual reviews to pertinent material elsewhere in the survey.

  10. Clinical and Radiographic Predictors of GOLD–Unclassified Smokers in the COPDGene Study

    PubMed Central

    Hokanson, John E.; Murphy, James R.; Regan, Elizabeth A.; Make, Barry J.; Lynch, David A.; Crapo, James D.; Silverman, Edwin K.

    2011-01-01

    Rationale: A significant proportion of smokers have lung function impairment characterized by a reduced FEV1 with a preserved FEV1/FVC ratio. These smokers are a poorly characterized group due to their systematic exclusion from chronic obstructive pulmonary disease (COPD) studies. Objectives: To characterize the clinical, functional, and radiographic features of Global Initiative for Chronic Obstructive Lung Disease (GOLD)-Unclassified (FEV1/FVC ≥ 0.7 and FEV1 < 80% predicted) and lower limits of normal (LLN)-unclassified (FEV1/FVC ≥ LLN and FEV1 < LLN) subjects compared to smokers with normal lung function and subjects with COPD. Methods: Data from the first 2,500 subjects enrolled in the COPDGene study were analyzed. All subjects had 10 or more pack-years of smoking and were between the ages of 45 and 80 years. Multivariate regression models were constructed to determine the clinical and radiological variables associated with GOLD-Unclassified (GOLD-U) and LLN-Unclassified status. Separate multivariate regressions were performed in the subgroups of subjects with complete radiologic measurement variables available. Measurements and Main Results: GOLD-U smokers account for 9% of smokers in COPDGene and have increased body mass index (BMI), a disproportionately reduced total lung capacity, and a higher proportion of nonwhite subjects and subjects with diabetes. GOLD-U subjects exhibit increased airway wall thickness compared to smoking control subjects and decreased gas trapping and bronchodilator responsiveness compared to subjects with COPD. When LLN criteria were used to define the “unclassified” group, African American subjects were no longer overrepresented. Both GOLD-U and LLN-Unclassified subjects demonstrated a wide range of lung function impairment, BMI, and percentage of total lung emphysema. Conclusions: Subjects with reduced FEV1 and a preserved FEV1/FVC ratio are a heterogeneous group with significant symptoms and functional limitation who

  11. Procedures to cover Spillage of Classified Information Onto Unclassified Systems

    EPA Pesticide Factsheets

    The purpose of this is to implement the security control requirements and outline actions required when responding to electronic spillage of classified national security information (classified information) onto unclassified information systems or devices.

  12. Remitting seronegative symmetrical synovitis with pitting edema (RS3PE): a form of paraneoplastic polyarthritis?

    PubMed

    Sibilia, J; Friess, S; Schaeverbeke, T; Maloisel, F; Bertin, P; Goichot, B; Kuntz, J L

    1999-01-01

    To describe the clinical and laboratory features and outcome of 6 patients presenting with remitting seronegative symmetrical synovitis with pitting edema (RS3PE) revealing a solid tumor. Patients with RS3PE who presented with a solid tumor and who had been seen between January 1, 1994, and December 31, 1996, were included in a retrospective multicenter analysis. These patients fulfilled McCarty's description of RS3PE and the following criteria: (1) bilateral pitting edema of both hands, (2) sudden onset of polyarthritis, (3) age >50 years, and (4) absence of rheumatoid factor (RF). Six male patients with RS3PE are described, of mean age 74 years (range 72-78), presenting prostatic (n = 4), gastric (n = 1), and colic (n = 1) adenocarcinomas. The clini cal picture was characterized by the classical form of RS3PE syndrome and by a deterioration in general condition, sometimes with fever. All patients were negative for RF and antinuclear antibodies. In 2 cases of prostatic adenocarcinoma serum levels of interleukin 6 (IL-6) were high, but decreased with treatment. In these 6 patients, the articular manifestations regressed totally or partially in response to corticosteroids, sometimes at low doses, associated in most cases with specific antitumoral therapy. None displayed erosion or distal bone destruction. The mean survival following discovery of RS3PE was 11 months (range 6-18), 5 patients dying of metastatic dissemination of their cancer and the 6th of myocardial infarction. RS3PE is a heterogeneous syndrome that can reveal a solid tumor, notably an adenocarcinoma. There exist no specific criteria to define its forms, but this syndrome should be kept in mind in the face of a deterioration in general health. Although the pathogenic mechanism is unknown, this could involve a type of paraneoplastic polyarthritis linked to the synthesis of a factor such as IL-6.

  13. Immune complexes and Ross River virus disease (epidemic polyarthritis).

    PubMed

    Fraser, J R; Cunningham, A L; Mathews, J D; Riglar, A

    1988-01-01

    Immune complexes were sought in serum and synovial fluid in Ross River virus disease (epidemic polyarthritis). Multiple samples from 15 patients showing varied degrees of disease activity over a 3 month period were analysed for their content of complement components C3 and C4, and for C1q solid-phase and Raji cell binding activity. Levels of C3 and C1q binding activity were normal. C4 and Raji cell binding activity were normal except for three high levels of Raji cell binding, of which two were accompanied by low levels of C4, with normal C3 and C1q binding. Synovial fluid showed anomalous Raji cell reactivity of uncertain significance. Conglutinin solid-phase binding activity and IgG rheumatoid factor were compared in the serum of 20 patients during active disease and after recovery. The results were identical and within the normal range in both phases. One patient developed IgM rheumatoid factor in a low titre late in his illness. Although these findings do not entirely exclude a role for immune complexes formed at the onset in the circulation or tissues, it is concluded from this and other evidence that circulating complexes are not commonly responsible for the persistence of syndromes in this disease.

  14. 14 CFR 1213.107 - Preventing unauthorized release of sensitive but unclassified (SBU) information/material to the...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... sensitive but unclassified (SBU) information/material to the news media. 1213.107 Section 1213.107... INFORMATION MEDIA § 1213.107 Preventing unauthorized release of sensitive but unclassified (SBU) information/material to the news media. (a) All NASA SBU information requires accountability and approval for release...

  15. 14 CFR 1213.107 - Preventing unauthorized release of sensitive but unclassified (SBU) information/material to the...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... sensitive but unclassified (SBU) information/material to the news media. 1213.107 Section 1213.107... INFORMATION MEDIA § 1213.107 Preventing unauthorized release of sensitive but unclassified (SBU) information/material to the news media. (a) All NASA SBU information requires accountability and approval for release...

  16. 14 CFR 1213.107 - Preventing unauthorized release of sensitive but unclassified (SBU) information/material to the...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... but unclassified (SBU) information/material to the news media. 1213.107 Section 1213.107 Aeronautics... MEDIA § 1213.107 Preventing unauthorized release of sensitive but unclassified (SBU) information/material to the news media. (a) All NASA SBU information requires accountability and approval for release...

  17. 14 CFR 1213.107 - Preventing unauthorized release of sensitive but unclassified (SBU) information/material to the...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... sensitive but unclassified (SBU) information/material to the news media. 1213.107 Section 1213.107... INFORMATION MEDIA § 1213.107 Preventing unauthorized release of sensitive but unclassified (SBU) information/material to the news media. (a) All NASA SBU information requires accountability and approval for release...

  18. 76 FR 22849 - DoD Unclassified Controlled Nuclear Information (UCNI)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-25

    ... computer or other information technology systems shall enforce protection from unauthorized disclosure or..., and control of the Under Secretary of Defense for Acquisition, Technology and Logistics, shall: (1... slides) containing DoD UCNI shall be conspicuously marked ``DOD UNCLASSIFIED CONTROLLED NUCLEAR...

  19. Chronic polyarthritis associated to Cercopithifilaria bainae infection in a dog.

    PubMed

    Gabrielli, Simona; Giannelli, Alessio; Brianti, Emanuele; Dantas-Torres, Filipe; Bufalini, Massimiliano; Fraulo, Maurizio; La Torre, Francesco; Ramos, Rafael A N; Cantacessi, Cinzia; Latrofa, Maria Stefania; Cancrini, Gabriella; Otranto, Domenico

    2014-09-15

    Despite the widespread distribution of Cercopithifilaria bainae among canine and tick populations worldwide, this filarioid is currently considered of 'minor importance' in veterinary medicine, particularly when compared to related filarioids, such as Dirofilaria immitis and Dirofilaria repens. To date, only a single case of dermatological alterations possibly associated to infection by C. bainae had been reported in a dog. In the present study, we describe the first case of systemic alterations associated to C. bainae infection in a dog suffering from diffused chronic polyarthritis. The animal had a previous history of reluctance to move and stiff gait and displayed multiple joint pain during manipulation of limbs. No biochemical, haematological and X-ray alterations were detected; microfilariae were observed in the synovial fluids collected from the joints. In spite of the morphological and molecular identification of these microfilariae as C. bainae, the dog did not respond to multiple microfilaricidal treatments with milbemicyn oxyme. The potential role of C. bainae in the pathogenesis of this clinical condition is discussed. Given the potential pathogenicity of this parasite, improved knowledge of this little known tick-borne nematode is warranted in order to assist the development of novel and effective treatment strategies. Copyright © 2014. Published by Elsevier B.V.

  20. Direct Tumor Embolization of Sinonasal Unclassified Spindle Cell Sarcoma with Onyx.

    PubMed

    Kansal, Ankit; Srinet, Prateek; Manes, Richard Peter

    2016-07-01

    To evaluate the use of a new tumor embolization agent, Onyx (Covidien, Dublin, Ireland), for the use of intraoperative embolization of a sinonasal unclassified spindle cell sarcoma. A 45-year-old female patient presented to the rhinology clinic with a nasal mass. A biopsy revealed a highly vascular mass consistent with a sinonasal unclassified spindle cell sarcoma. Secondary to its extensive vascularity, the patient underwent preoperative transarterial embolization (TAE) before definitive resection. Due to complex vascular anatomy including feeding vessels emanating from intracranial circulation, incomplete embolization was achieved. Subsequently, intraoperative embolization with Onyx at the time of resection was performed. Intraoperative Onyx use resulted in almost complete devascularization of the tumor with decreased risk of intracranial embolization. Intraoperative embolization with Onyx after an incomplete TAE can be a safe and effective method of achieving near-total embolization of sinonasal tumors.

  1. 77 FR 43506 - DoD Unclassified Controlled Nuclear Information (UCNI)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... Systems. (i) Information on the layout or design of security and alarm systems at a specific DoD SNM or... information is not observable from a public area. (iii) Performance characteristics of installed systems. (5... 0790-AI64 DoD Unclassified Controlled Nuclear Information (UCNI) AGENCY: Department of Defense. ACTION...

  2. Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome: MRI features of intraosseous fat necrosis involving the feet and knees.

    PubMed

    Kang, Dong Joo; Lee, Sun Joo; Choo, Hye Jung; Her, Minyoung; Yoon, Hye Kyoung

    2017-02-01

    Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome is extremely rare and presents as a triad of the three diseases. The patient usually presents with mild or absent abdominal symptoms. Here, we report on a case of a 66-year-old male who presented with pain and swelling in both legs and mild abdominal pain. He was diagnosed with acute pancreatitis by pancreatic enzyme analysis and abdominal computed tomography (CT) and with skin lesions of panniculitis through a biopsy. Magnetic resonance imaging (MRI) revealed multifocal intraosseous fat necrosis and arthritis involving both the feet and the knees. Therefore, we report a case of PPP syndrome with intraosseous fat necrosis involving both the feet and the knees.

  3. Cytokine profile in canine immune-mediated polyarthritis and osteoarthritis.

    PubMed

    Hegemann, N; Wondimu, A; Kohn, B; Brunnberg, L; Schmidt, M F G

    2005-01-01

    The purpose of this study was to determine the cytokine profile in 21 dogs with canine immune-mediated polyarthritis (IMA) and 15 dogs with osteoarthritis (OA) caused by cranial cruciate ligament rupture (CCLR). The mRNA expression of interleukin (IL)-1alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-18, interferon (IFN)-gamma, transforming growth factor (TGF)-beta, and tumour necrosis factor (TNF)-alpha were analysed in synovial fluid by semi-quantitative RT-PCR, while TNF-alpha protein was determined by L929 cytotoxicity assay. The frequency of lymphocytes was analysed using FACScan. Both disorders reveal a similar cytokine expression pattern, except for significant lower IL-1beta expression in OA. Th1 cytokines IL-2 and IFN-gamma were detected, while IL-4 was nearly absent in IMA and OA. Furthermore, the bioassay demonstrates a significantly higher production of TNF-alpha in synovial fluid of dogs with IMA, compared to dogs with OA (p < 0.05). The frequency of CD4+, CD8+ and MHC class II+ cells was relatively higher in synovial fluids compared to peripheral blood in IMA. These findings reveal that the difference between the cytokine pattern of canine IMA and OA seems to be rather quantitative than qualitative. Both joint disorders show predominance of pro-inflammatory cytokines and absence of TH2 cytokine expression, indicating the potential of IL-4 for a gene therapeutic approach.

  4. A guide to unclassified sensitive information protection

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Donahue, S.C.

    1996-11-14

    This document is a reference guide for CIC-Division employees who lead or participate in projects that use and/or produce unclassified sensitive information. It is intended for use on a case by case basis to develop project specific sensitive information handling procedures and standards. It contains criteria for identifying sensitive information and determining levels of sensitivity, and describes cost effective measures for protecting various levels of sensitive information. The goal of this document is to help establish good business practices that benefit both the Laboratory and its customers. Division personnel are encouraged to apply these guidelines.

  5. A retrospective study of 40 dogs with polyarthritis.

    PubMed

    Jacques, David; Cauzinille, Laurent; Bouvy, Bernard; Dupre, Gilles

    2002-01-01

    To characterize the epidemiologic, clinical, laboratory, and radiographic findings from dogs with polyarthritis (PA). Retrospective clinical study. Forty dogs. Medical records of 40 dogs with a diagnosis of PA were reviewed. Retrieved data included breed, age at admission, sex, weight, clinical signs, and the results of synovial fluid analysis, complete blood count, serum chemistry profile, urinalysis, serologic screening tests for infectious diseases, and radiographic examination of affected joints. The incidence of PA was 0.37%. Twenty-nine breeds were represented; 16 dogs were male, and 24 were female. Mean body weight was 20.1 +/- 15 kg. The mean age at admission was 5.6 +/- 4 years. Eighty percent of dogs with PA had difficulty or reluctance walking, 35% were lame, 33% had spontaneous vocalization without any obvious reason, 20% had exercise intolerance, 18% were febrile, and 7.5% had an inability to rise or move. Joint pain was identified in 40% of dogs. Synovial fluid color varied from colorless (36%) to yellow-tinged (36%) or hemorrhagic (28%). Synovial fluid mean cell count varied from 10 cells (400x) to 50 cells (1,000x). Leukocytosis occurred in 59% of the dogs and was more frequently identified in dogs with very severe synovial inflammation. Thirty-one percent of affected dogs were anemic. Serum biochemical profiles were considered abnormal in 13% of the dogs. Joint radiography did not identify erosive arthritis. PA is a common cause of locomotor abnormalities in dogs; however, true lameness and articular pain are not common clinical findings in dogs with PA. PA should be considered in the differential diagnosis for all dogs with difficulty walking. Copyright 2002 by The American College of Veterinary Surgeons

  6. An unclassified Eubacterium taxon in acute dento-alveolar abscess.

    PubMed

    Wade, W G; Lewis, M A; Cheeseman, S L; Absi, E G; Bishop, P A

    1994-02-01

    The microflora of pus samples aspirated from 50 acute dento-alveolar abscesses was examined. A total of 143 bacterial strains was isolated, consisting predominantly of Prevotella spp., alpha-haemolytic Streptococcus spp., Peptostreptococcus spp. and Eubacterium spp. An unclassified asaccharolytic Eubacterium taxon was encountered in 17 (34%) of the abscesses. This taxon was found to have a positive association with Fusobacterium spp. and a negative association with alpha-haemolytic Streptococcus spp.

  7. [Vulvovaginitis. Occurrence and importance of mixed and unclassifiable pictures].

    PubMed

    Líbalová, Z; Cepický, P; Malina, J; Stanslický, K; Kuzelová, M; Medalová, Z; Sosnová, K

    2007-01-01

    To evaluate the occurrence of mixed and unclassifiable vulvovaginitis (i.e. those, which fulfill the diagnostic criteria of several diagnostic units or no diagnostic unit) in symptomatic and asymptomatic women. Prospective study. In 412 women (115 of them asymptomatic) the authors established the diagnosis of vulvovaginitis on the basis of gynecological examination, pH, the amine test and microscopic examination according to Giemsa and Gram. Mycosis was diagnosed in 15.5% women (in 9,6% of asymptomatic ones), lactobacillosis in u 5.6% (in 7.0% of asymptomatic), anaerobic vaginosis in 10.7% (8.7% of asymptomatic), aerobic vaginitis in 7.7% women (4.3% of asymptomatic). U 15.0% mixed infections were diagnosed (in 61% asymptomatic). U 29.4% symptomatic women the diagnostic criteria were not fulfilled for any nosological unit. Vulvovaginal mycosis, lactobacillosis, anaerobic vaginosis, aerobic vaginosis were considered as dysmicrobia conditions. The authors demonstrated a high occurrence of more units ("clear" diagnoses to "mixed" diagnoses being in the ratio of 1.62:1). The authors also demonstrated a high occurrence of mixed infections in asymptomatic women (36.0%). On the contrary, in 29.4% of symptomatic women the diagnosis could not be established, the findings being "normal" or "unclassifiable".

  8. Identification of an unclassified paramyxovirus in Coleura afra: a potential case of host specificity.

    PubMed

    Maganga, Gael D; Bourgarel, Mathieu; Obame Nkoghe, Judicael; N'Dilimabaka, Nadine; Drosten, Christian; Paupy, Christophe; Morand, Serge; Drexler, Jan Felix; Leroy, Eric M

    2014-01-01

    Bats are known to harbor multiple paramyxoviruses. Despite the creation of two new genera, Aquaparamyxovirus and Ferlavirus, to accommodate this increasing diversity, several recently isolated or characterized viruses remain unclassified beyond the subfamily level. In the present study, among 985 bats belonging to 6 species sampled in the Belinga caves of Gabon, RNA of an unclassified paramyxovirus (Belinga bat virus, BelPV) was discovered in 14 African sheath-tailed bats (Coleura afra), one of which exhibited several hemorrhagic lesions at necropsy, and viral sequence was obtained in two animals. Phylogenetically, BelPV is related to J virus and Beilong virus (BeiPV), two other unclassified paramyxoviruses isolated from rodents. In the diseased BelPV-infected C. afra individual, high viral load was detected in the heart, and the lesions were consistent with those reported in wild rodents and mice experimentally infected by J virus. BelPV was not detected in other tested bat species sharing the same roosting sites and living in very close proximity with C. afra in the two caves sampled, suggesting that this virus may be host-specific for C. afra. The mode of transmission of this paramyxovirus in bat populations remains to be discovered.

  9. Sound Propagation in Shallow Water. Volume 2. Unclassified Papers

    DTIC Science & Technology

    1974-11-15

    and 22°. The component of the sound pressure normal to the sea-bottom has been received by a movable, motor -driven hydrophone (LC 10...the motor , the operation-status of which was controlled by magnetic relays. The total measuring interval was 44.5 cm. 16 NATO UNCLASSIFIED jmm...Then one may hope to learn , which criteria make different sea areas acoustically similar. To estimate the hierarchy of the environmental influences, a

  10. 48 CFR 1852.204-76 - Security requirements for unclassified information technolocgy resources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Officer for approval by the Network Security Configuration Control Board (NSCCB); (ii) Comply with the... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Security requirements for... CONTRACT CLAUSES Texts of Provisions and Clauses 1852.204-76 Security requirements for unclassified...

  11. The myeloproliferative neoplasms, unclassifiable: clinical and pathological considerations.

    PubMed

    Gianelli, Umberto; Cattaneo, Daniele; Bossi, Anna; Cortinovis, Ivan; Boiocchi, Leonardo; Liu, Yen-Chun; Augello, Claudia; Bonometti, Arturo; Fiori, Stefano; Orofino, Nicola; Guidotti, Francesca; Orazi, Attilio; Iurlo, Alessandra

    2017-02-01

    In this study, we investigate in detail the morphological, clinical and molecular features of 71 consecutive patients with a diagnosis of myeloproliferative neoplasms, unclassifiable. We performed a meticulous morphological analysis and found that most of the cases displayed a hypercellular bone marrow (70%) with normal erythropoiesis without left-shifting (59%), increased granulopoiesis with left-shifting (73%) and increased megakaryocytes with loose clustering (96%). Megakaryocytes displayed frequent giant forms with hyperlobulated or bulbous nuclei and/or other maturation defects. Interestingly, more than half of the cases displayed severe bone marrow fibrosis (59%). Median values of hemoglobin level and white blood cells count were all within the normal range; in contrast, median platelets count and lactate dehydrogenase were increased. Little less than half of the patients (44%) showed splenomegaly. JAK2V617F mutation was detected in 72% of all patients. Among the JAK2-negative cases, MPLW515L mutation was found in 17% and CALR mutations in 67% of the investigated cases, respectively. Finally, by multiple correspondence analysis of the morphological profiles, we found that all but four of the cases could be grouped in three morphological clusters with some features similar to those of the classic BCR-ABL1-negative myeloproliferative neoplasms. Analysis of the clinical parameters in these three clusters revealed discrepancies with the morphological profile in about 55% of the patients. In conclusion, we found that the category of myeloproliferative neoplasm, unclassifiable is heterogeneous but identification of different subgroups is possible and should be recommended for a better management of these patients.

  12. Identification of an Unclassified Paramyxovirus in Coleura afra: A Potential Case of Host Specificity

    PubMed Central

    Maganga, Gael D.; Bourgarel, Mathieu; Obame Nkoghe, Judicael; N'Dilimabaka, Nadine; Drosten, Christian; Paupy, Christophe; Morand, Serge; Drexler, Jan Felix; Leroy, Eric M.

    2014-01-01

    Bats are known to harbor multiple paramyxoviruses. Despite the creation of two new genera, Aquaparamyxovirus and Ferlavirus, to accommodate this increasing diversity, several recently isolated or characterized viruses remain unclassified beyond the subfamily level. In the present study, among 985 bats belonging to 6 species sampled in the Belinga caves of Gabon, RNA of an unclassified paramyxovirus (Belinga bat virus, BelPV) was discovered in 14 African sheath-tailed bats (Coleura afra), one of which exhibited several hemorrhagic lesions at necropsy, and viral sequence was obtained in two animals. Phylogenetically, BelPV is related to J virus and Beilong virus (BeiPV), two other unclassified paramyxoviruses isolated from rodents. In the diseased BelPV-infected C. afra individual, high viral load was detected in the heart, and the lesions were consistent with those reported in wild rodents and mice experimentally infected by J virus. BelPV was not detected in other tested bat species sharing the same roosting sites and living in very close proximity with C. afra in the two caves sampled, suggesting that this virus may be host-specific for C. afra. The mode of transmission of this paramyxovirus in bat populations remains to be discovered. PMID:25551455

  13. 48 CFR 3004.470 - Security requirements for access to unclassified facilities, Information Technology resources...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... access to unclassified facilities, Information Technology resources, and sensitive information. 3004.470... Technology resources, and sensitive information. ... ACQUISITION REGULATION (HSAR) GENERAL ADMINISTRATIVE MATTERS Safeguarding Classified and Sensitive Information...

  14. 48 CFR 3004.470 - Security requirements for access to unclassified facilities, Information Technology resources...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... access to unclassified facilities, Information Technology resources, and sensitive information. 3004.470... Technology resources, and sensitive information. ... ACQUISITION REGULATION (HSAR) GENERAL ADMINISTRATIVE MATTERS Safeguarding Classified and Sensitive Information...

  15. 48 CFR 3004.470 - Security requirements for access to unclassified facilities, Information Technology resources...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... access to unclassified facilities, Information Technology resources, and sensitive information. 3004.470... Technology resources, and sensitive information. ... ACQUISITION REGULATION (HSAR) GENERAL ADMINISTRATIVE MATTERS Safeguarding Classified and Sensitive Information...

  16. 48 CFR 3004.470 - Security requirements for access to unclassified facilities, Information Technology resources...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... access to unclassified facilities, Information Technology resources, and sensitive information. 3004.470... Technology resources, and sensitive information. ... ACQUISITION REGULATION (HSAR) GENERAL ADMINISTRATIVE MATTERS Safeguarding Classified and Sensitive Information...

  17. 48 CFR 3004.470 - Security requirements for access to unclassified facilities, Information Technology resources...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... access to unclassified facilities, Information Technology resources, and sensitive information. 3004.470... Technology resources, and sensitive information. ... ACQUISITION REGULATION (HSAR) GENERAL ADMINISTRATIVE MATTERS Safeguarding Classified and Sensitive Information...

  18. [Diagnosis for human parvovirus B19-polyarthritis: usefulness of empty particle B19.ELISA and B19-DNA.PCR].

    PubMed

    Hatakeyama, Y; Ishii, K; Murai, C; Sugamura, K; Mitomo, N; Saitoh, T; Rikimaru, Y; Okazaki, T; Sasaki, T

    1998-10-01

    To evaluate the usefulness of new ELISA for human parvovirus B19 (B19) antibodies and PCR for the diagnosis of acute onset of B19 polyarthritis. We evaluated the reproducibility and sensitivity on the detection of anti-B19 antibody by ELISA using recombinant VP-1 and VP-2 (empty particle), and then studied for the prevalence of IgM and IgG B19 antibody in 125 samples for anti-B19 tests. The random study on anti-B19 antibody assay as well as PCR for B19-DNA was also performed in 130 cases with acute onset of arthritis excluding those with known origins, 224 with rheumatoid arthritis and 149 with other categories. The results by using B19-empty particle ELISA were reproducible and showed the assay was a sensitive way for clinical use. IgM anti-B19 antibodies were positive not only in all samples from erythema infectiosum, but also often in those from hemolytic anemia, pure red cell aplasia, fetal hydrops, hepatic injury, fever of unknown origin. Among 130 with acute onset of arthritis, 21 showed positive tests for IgM anti-B19 antibody and/or B19 DNA. On the other hand, 4 among 224 patients with rheumatoid arthritis were positive for IgM anti-B19 antibody, but all of 149 in control group were negative for IgM anti-B19 antibodies and for B19 DNA. Anti-B19 ELISA using B19-empty particle which has been introduced as a routine test system, is a useful tool for the diagnosis of acute onset of B19 arthritis. An additional examination using PCR for B19 DNA may contribute for understanding persistent B19 polyarthritis or reactivation of B19 infection.

  19. 3 CFR 13556 - Executive Order 13556 of November 4, 2010. Controlled Unclassified Information

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... Controlled Unclassified Information 13556 Order 13556 Presidential Documents Executive Orders Executive Order... information, such as information that involves privacy, security, proprietary business interests, and law... safeguarding of documents, led to unclear or unnecessarily restrictive dissemination policies, and created...

  20. Cosmeceuticals: undefined, unclassified, and unregulated.

    PubMed

    Draelos, Zoe Diana

    2009-01-01

    The cosmeceutical category is an undefined, unclassified, and unregulated area of dermatology that is yet in its infancy. Traditional cosmeceuticals involve the topical application of biologically active ingredients that affect the skin barrier and overall skin health. The ability of these ingredients to enhance skin functioning depends on how they are formulated into products that can maintain the integrity of the active ingredient, deliver it in a biologically active form to the skin, reach the target site in sufficient quantity to exert an effect, and properly release from the carrier vehicle. In the United States, cosmeceuticals are sold as cosmetics, making marketing, packaging, and aesthetic appeal important considerations. Ideally, the cosmeceutical should be clinically tested for efficacy to ensure a proven skin benefit and also to substantiate marketing claims. Governmental limitations of efficacy claims restrict cosmeceutical development because products can only be assessed in terms of their ability to improve skin appearance but not function. Improving function would remove the cosmeceutical from the cosmetic category and place it in the drug category. Herein lies the challenge of defining the cosmeceutical category.

  1. Long-term effects of a nurse-led group and individual patient education programme for patients with chronic inflammatory polyarthritis - a randomised controlled trial.

    PubMed

    Grønning, Kjersti; Rannestad, Toril; Skomsvoll, Johan F; Rygg, Lisbeth Ø; Steinsbekk, Aslak

    2014-04-01

    To investigate the long-term effect of a nurse-led hospital-based patient education programme combining group and individual education for patients with chronic inflammatory polyarthritis. Patient education interventions have shown short-term effects, but few studies have investigated whether the effects are sustained for a longer period. Randomised controlled trial. Patients with rheumatoid arthritis, psoriatic arthritis and unspecified polyarthritis were randomised to the intervention group (n = 71) or a waiting list (n = 70). Primary outcomes were as follows: Global Well-Being and the Arthritis Self-Efficacy Other Symptoms Subscale. Secondary outcomes were as follows: patient activation, physical and psychological health status, patients' educational needs and a Disease Activity Score (DAS28-3). The intervention group had a statistically significant higher global well-being than the controls after 12 months, mean change score 8·2 (95% CI, 1·6-14·8; p-value = 0·015), but not in the Arthritis Self-Efficacy Other Symptoms Subscale, mean change score 2·6 (95% CI, -1·8 to 7·1; p-value = 0·245). Within each group, analyses showed a statistically significant improvement in DAS28-3, mean change -0·3 (95% CI, -0·5 to -0·1; p-value = 0·001), in the intervention group from baseline to 12 months, but not in the controls. The controls had a statistically significant deterioration in the Arthritis Self-Efficacy Other Symptoms Subscale, mean change -5·0 (95% CI, -8·6 to -1·3; p-value = 0·008), Arthritis Impact Measurement Scales - 2 Social, mean change 0·3 (95% CI, 0·1-0·5; p-value = 0·008), and Hospital Anxiety and Depression Scale total, mean change 1·4 (95% CI, 0·3-2·5; p-value = 0·013). A combination of group and individual patient education has a long-term effect on patients' global well-being. Nurses should consider whether a combination of group and individual patient education for patients with chronic inflammatory polyarthritis is an

  2. Alfalfa Intervention Alters Rumen Microbial Community Development in Hu Lambs During Early Life.

    PubMed

    Yang, Bin; Le, Jiaqing; Wu, Peng; Liu, Jianxin; Guan, Le L; Wang, Jiakun

    2018-01-01

    The pre-weaning period is crucial for rumen developmental plasticity, which can have a long-term impact on animal performance. Understanding the rumen microbiota during early life is important to elucidate its potential role in rumen development. In this study, the rumen microbiota of 10-day-old Hu lambs fed either milk replacer (B-10), milk replacer and starter (STA) or milk replacer and starter supplemented with alfalfa (S-ALF) in the pre- (d17, 24, and 38) and post-weaning periods (d45 and 66) were assessed to characterize rumen microbial colonization during early life and its response to fiber intervention. In the rumens of B-10 lambs, 498 operational taxonomic units belonging to 33 predominant genera were observed, and the top six predicted functions included "Membrane transport," "carbohydrate metabolism," "amino acid metabolism," "replication and repair," "translation," and "energy metabolism." Prevotella , Succinivibrio , Bifidobacterium , and Butyrivibrio abundances were increased at d38 for both STA and S-ALF groups compared to the B-10 group, whereas fibrolytic bacteria of the taxa Lachnospiraceae and Treponema were only increased in the S-ALF group at d38. A number of saccharolytic bacteria ( Bacteroidaceae ), organic acid-producing bacteria ( Coprococcus and Actinomyces ), proteolytic and amino acid fermenters ( Fusobacterium ) and fibrolytic bacteria (unclassified Ruminococcaceae ) were significantly decreased in the STA lambs but not in the S-ALF lambs at d38. After weaning and exposed to alfalfa, the rumen microbial composition in the STA group started to appear similar to that of the S-ALF lambs. The relative abundance of unclassified Clostridiales was higher in S-ALF lambs than STA lambs after weaning. Spearman's correlation analysis showed positive relationships between unclassified Lachnospiraceae , unclassified Clostridiales , Treponema , unclassified Bacteroidales , Coprococcus and crude protein intake, neutral detergent fiber intake, and

  3. 76 FR 38089 - Defense Federal Acquisition Regulation Supplement; Safeguarding Unclassified DoD Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... encryption of data for storage and transmission, network protection and intrusion detection, and cyber... review of its unclassified network for evidence of intrusion to include, but is not limited to... DoD information within industry, nor does it address cyber intrusion reporting for that information...

  4. Alfalfa Intervention Alters Rumen Microbial Community Development in Hu Lambs During Early Life

    PubMed Central

    Yang, Bin; Le, Jiaqing; Wu, Peng; Liu, Jianxin; Guan, Le L.; Wang, Jiakun

    2018-01-01

    The pre-weaning period is crucial for rumen developmental plasticity, which can have a long-term impact on animal performance. Understanding the rumen microbiota during early life is important to elucidate its potential role in rumen development. In this study, the rumen microbiota of 10-day-old Hu lambs fed either milk replacer (B-10), milk replacer and starter (STA) or milk replacer and starter supplemented with alfalfa (S-ALF) in the pre- (d17, 24, and 38) and post-weaning periods (d45 and 66) were assessed to characterize rumen microbial colonization during early life and its response to fiber intervention. In the rumens of B-10 lambs, 498 operational taxonomic units belonging to 33 predominant genera were observed, and the top six predicted functions included “Membrane transport,” “carbohydrate metabolism,” “amino acid metabolism,” “replication and repair,” “translation,” and “energy metabolism.” Prevotella, Succinivibrio, Bifidobacterium, and Butyrivibrio abundances were increased at d38 for both STA and S-ALF groups compared to the B-10 group, whereas fibrolytic bacteria of the taxa Lachnospiraceae and Treponema were only increased in the S-ALF group at d38. A number of saccharolytic bacteria (Bacteroidaceae), organic acid-producing bacteria (Coprococcus and Actinomyces), proteolytic and amino acid fermenters (Fusobacterium) and fibrolytic bacteria (unclassified Ruminococcaceae) were significantly decreased in the STA lambs but not in the S-ALF lambs at d38. After weaning and exposed to alfalfa, the rumen microbial composition in the STA group started to appear similar to that of the S-ALF lambs. The relative abundance of unclassified Clostridiales was higher in S-ALF lambs than STA lambs after weaning. Spearman’s correlation analysis showed positive relationships between unclassified Lachnospiraceae, unclassified Clostridiales, Treponema, unclassified Bacteroidales, Coprococcus and crude protein intake, neutral detergent fiber

  5. Extending bicluster analysis to annotate unclassified ORFs and predict novel functional modules using expression data

    PubMed Central

    Bryan, Kenneth; Cunningham, Pádraig

    2008-01-01

    Background Microarrays have the capacity to measure the expressions of thousands of genes in parallel over many experimental samples. The unsupervised classification technique of bicluster analysis has been employed previously to uncover gene expression correlations over subsets of samples with the aim of providing a more accurate model of the natural gene functional classes. This approach also has the potential to aid functional annotation of unclassified open reading frames (ORFs). Until now this aspect of biclustering has been under-explored. In this work we illustrate how bicluster analysis may be extended into a 'semi-supervised' ORF annotation approach referred to as BALBOA. Results The efficacy of the BALBOA ORF classification technique is first assessed via cross validation and compared to a multi-class k-Nearest Neighbour (kNN) benchmark across three independent gene expression datasets. BALBOA is then used to assign putative functional annotations to unclassified yeast ORFs. These predictions are evaluated using existing experimental and protein sequence information. Lastly, we employ a related semi-supervised method to predict the presence of novel functional modules within yeast. Conclusion In this paper we demonstrate how unsupervised classification methods, such as bicluster analysis, may be extended using of available annotations to form semi-supervised approaches within the gene expression analysis domain. We show that such methods have the potential to improve upon supervised approaches and shed new light on the functions of unclassified ORFs and their co-regulation. PMID:18831786

  6. Influence of arthritis and non-arthritis related factors on areal bone mineral density (BMDa) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort.

    PubMed

    Pye, Stephen R; Marshall, Tarnya; Gaffney, Karl; Silman, Alan J; Symmons, Deborah P M; O'Neill, Terence W

    2010-05-28

    The aim of this analysis was to determine the relative influence of disease and non-disease factors on areal bone mineral density (BMDa) in a primary care based cohort of women with inflammatory polyarthritis. Women aged 16 years and over with recent onset inflammatory polyarthritis were recruited to the Norfolk Arthritis Register (NOAR) between 1990 and 1993. Subjects were examined at both baseline and follow up for the presence of tender, swollen and deformed joints. At the 10th anniversary visit, a sub-sample of women were invited to complete a bone health questionnaire and attend for BMDa (Hologic, QDR 4000). Linear regression was used to examine the association between BMDa with both (i) arthritis-related factors assessed at baseline and the 10th anniversary visit and (ii) standard risk factors for osteoporosis. Adjustments were made for age. 108 women, mean age 58.0 years were studied. Older age, decreasing weight and BMI at follow up were all associated with lower BMDa at both the spine and femoral neck. None of the lifestyle factors were linked. Indices of joint damage including 10th anniversary deformed joint count and erosive joint count were the arthritis-related variables linked with a reduction in BMDa at the femoral neck. By contrast, disease activity as determined by the number of tender and or swollen joints assessed both at baseline and follow up was not linked with BMDa at either site. Cumulative disease damage was the strongest predictor of reduced femoral bone density. Other disease and lifestyle factors have only a modest influence.

  7. Identification of Classified Information in Unclassified DoD Systems During the Audit of Internal Controls and Data Reliability in the Deployable Disbursing System

    DTIC Science & Technology

    2009-02-17

    Identification of Classified Information in Unclassified DoD Systems During the Audit of Internal Controls and Data Reliability in the Deployable...TITLE AND SUBTITLE Identification of Classified Information in Unclassified DoD Systems During the Audit of Internal Controls and Data Reliability...Systems During the Audit ofInternal Controls and Data Reliability in the Deployable Disbursing System (Report No. D-2009-054) Weare providing this

  8. Unclassified cases of behavioral variant of major frontotemporal neurocognitive disorder in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition.

    PubMed

    Fukuda, Koji; Hattori, Hideyuki

    2014-04-01

    In the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5), the behavioral variant of major frontotemporal neurocognitive disorder (bvFT-NCD) is subclassified into "probable bvFT-NCD" or "possible bvFT-NCD." When genetic evidence is unavailable, cases without clinical neuroimaging are subclassified into "possible bvFT-NCD," whereas cases whose clinical images show the typical characteristics are subclassified into "probable bvFT-NCD." Thus, the cases that meet the diagnostic criteria of bvFT-NCD based on their symptoms, but lack the neuroimaging characteristics, fall between the two categories of probable and possible bvFT-NCD. These cases herein are defined as "unclassified bvFT-NCD," and the present study aims at considering an appropriate diagnostic approach to such cases, that is, whether unclassified bvFT-NCD should be included in bvFT-NCD as a third subcategory, or whether it should be classified into diseases other than bvFT-NCD. All patients who presented at the Department of Psychiatry of the National Center for Geriatrics and Gerontology with suspicion of the behavioral variant of frontotemporal dementia between 1 May 2011 and 30 April 2013 were retrospectively rediagnosed based on the DSM-5 criteria. A total of 16 cases met the criteria of bvFT-NCD, and among them, eight cases corresponded to unclassified bvFT-NCD. From a cross-sectional and clinical perspective, all eight cases of unclassified bvFT-NCD fulfilled the symptomatic criteria for bvFT-NCD, although the possibilities of Alzheimer's disease and other mental disorders could not be ruled out completely. To establish clinical diagnostic criteria for unclassified bvFT-NCD, accumulation of cases and evidence will be required along with longitudinal observation using various diagnostic technologies and post-mortem examination. © 2014 Japan Geriatrics Society.

  9. 14 CFR § 1213.107 - Preventing unauthorized release of sensitive but unclassified (SBU) information/material to the...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... sensitive but unclassified (SBU) information/material to the news media. § 1213.107 Section § 1213.107 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RELEASE OF INFORMATION TO NEWS AND.../material to the news media. (a) All NASA SBU information requires accountability and approval for release...

  10. Sensitive But Unclassified Information and Other Controls: Policy and Options for Scientific and Technical Information

    DTIC Science & Technology

    2006-12-29

    access to scientific and technical information (S& T ) for legitimate uses while protecting it from potential terrorists poses difficult policy choices...September 11, 2001 terrorist attacks, controls increasingly have been placed on some unclassified research and S& T information, including that used to...identify SBU information, especially S& T information; how to keep it from terrorists, while allowing access for those who need to use it; and how to

  11. Level-2 Milestone 6007: Sierra Early Delivery System Deployed to Secret Restricted Network

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bertsch, A. D.

    This report documents the delivery and installation of Shark, a CORAL Sierra early delivery system deployed on the LLNL SRD network. Early ASC program users have run codes on the machine in support of application porting for the final Sierra system which will be deployed at LLNL in CY2018. In addition to the SRD resource, Shark, unclassified resources, Rzmanta and Ray, have been deployed on the LLNL Restricted Zone and Collaboration Zone networks in support of application readiness for the Sierra platform.

  12. Association between socioeconomic status, learned helplessness, and disease outcome in patients with inflammatory polyarthritis.

    PubMed

    Camacho, E M; Verstappen, S M M; Symmons, D P M

    2012-08-01

    Independent investigations have shown that socioeconomic status (SES) and learned helplessness (LH) are associated with poor disease outcome in patients with rheumatoid arthritis (RA). Our aim was to investigate the cross-sectional relationship between SES, LH, and disease outcome in patients with recent-onset inflammatory polyarthritis (IP), the broader group of conditions of which RA is the major constituent. SES was measured using the Index of Multiple Deprivation 2007 for 553 patients consecutively recruited to the Norfolk Arthritis Register. Patients also completed the Rheumatology Attitudes Index, a measure of LH. SES and LH were investigated as predictors of disease outcome (functional disability [Health Assessment Questionnaire (HAQ)] and disease activity [Disease Activity Score in 28 joints]) in a regression analysis, adjusted for age, sex, and symptom duration. The role of LH in the relationship between SES and disease outcome was then investigated. Compared to patients of the highest SES, those of the lowest SES had a significantly worse outcome (median difference in HAQ score 0.42; 95% confidence interval [95% CI] 0.08, 0.75). Compared to patients with normal LH, patients with low LH had a significantly better outcome and patients with high LH had a significantly worse outcome (median difference in HAQ score 1.12; 95% CI 0.82, 1.41). There was a significant likelihood that LH mediated the association between SES and disease outcome (P = 0.04). LH is robustly associated with cross-sectional disease outcome in patients with IP, and appears to mediate the relationship between SES and disease outcome. As LH is potentially modifiable, these findings have potential clinical implications. Copyright © 2012 by the American College of Rheumatology.

  13. Association between socioeconomic status, learned helplessness, and disease outcome in patients with inflammatory polyarthritis

    PubMed Central

    Camacho, E M; Verstappen, S M M; Symmons, D P M

    2012-01-01

    Objective Independent investigations have shown that socioeconomic status (SES) and learned helplessness (LH) are associated with poor disease outcome in patients with rheumatoid arthritis (RA). Our aim was to investigate the cross-sectional relationship between SES, LH, and disease outcome in patients with recent-onset inflammatory polyarthritis (IP), the broader group of conditions of which RA is the major constituent. Methods SES was measured using the Index of Multiple Deprivation 2007 for 553 patients consecutively recruited to the Norfolk Arthritis Register. Patients also completed the Rheumatology Attitudes Index, a measure of LH. SES and LH were investigated as predictors of disease outcome (functional disability [Health Assessment Questionnaire (HAQ)] and disease activity [Disease Activity Score in 28 joints]) in a regression analysis, adjusted for age, sex, and symptom duration. The role of LH in the relationship between SES and disease outcome was then investigated. Results Compared to patients of the highest SES, those of the lowest SES had a significantly worse outcome (median difference in HAQ score 0.42; 95% confidence interval [95% CI] 0.08, 0.75). Compared to patients with normal LH, patients with low LH had a significantly better outcome and patients with high LH had a significantly worse outcome (median difference in HAQ score 1.12; 95% CI 0.82, 1.41). There was a significant likelihood that LH mediated the association between SES and disease outcome (P = 0.04). Conclusion LH is robustly associated with cross-sectional disease outcome in patients with IP, and appears to mediate the relationship between SES and disease outcome. As LH is potentially modifiable, these findings have potential clinical implications. PMID:22438290

  14. 10 CFR 1044.09 - What do you do if you plan to disclose classified or unclassified controlled nuclear information...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false What do you do if you plan to disclose classified or unclassified controlled nuclear information orally rather than by providing copies of documents? 1044.09 Section 1044.09 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SECURITY REQUIREMENTS FOR PROTECTED DISCLOSURES UNDER SECTION 3164 OF THE NATIONAL...

  15. 10 CFR 1044.09 - What do you do if you plan to disclose classified or unclassified controlled nuclear information...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false What do you do if you plan to disclose classified or unclassified controlled nuclear information orally rather than by providing copies of documents? 1044.09 Section 1044.09 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SECURITY REQUIREMENTS FOR PROTECTED DISCLOSURES UNDER SECTION 3164 OF THE NATIONAL...

  16. 10 CFR 1044.09 - What do you do if you plan to disclose classified or unclassified controlled nuclear information...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false What do you do if you plan to disclose classified or unclassified controlled nuclear information orally rather than by providing copies of documents? 1044.09 Section 1044.09 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SECURITY REQUIREMENTS FOR PROTECTED DISCLOSURES UNDER SECTION 3164 OF THE NATIONAL...

  17. 10 CFR 1044.09 - What do you do if you plan to disclose classified or unclassified controlled nuclear information...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false What do you do if you plan to disclose classified or unclassified controlled nuclear information orally rather than by providing copies of documents? 1044.09 Section 1044.09 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SECURITY REQUIREMENTS FOR PROTECTED DISCLOSURES UNDER SECTION 3164 OF THE NATIONAL...

  18. 10 CFR 1044.09 - What do you do if you plan to disclose classified or unclassified controlled nuclear information...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false What do you do if you plan to disclose classified or unclassified controlled nuclear information orally rather than by providing copies of documents? 1044.09 Section 1044.09 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SECURITY REQUIREMENTS FOR PROTECTED DISCLOSURES UNDER SECTION 3164 OF THE NATIONAL...

  19. Metastatic phaeochromocytoma in a 23-year-old woman with an unclassified variant in the von Hippel Lindau disease gene: how can the pathogenicity of this variant be determined?

    PubMed

    Russell, Nicholas; Delatycki, Martin; Grossmann, Mathis

    2015-07-01

    A 23-year-old woman with metastatic phaeochromocytoma was found to have a previously unclassified variant in the von Hippel Lindau disease gene (c.361G>C). We use this case to highlight the issue of unclassified single nucleotide variants and the approaches to help predict whether they are disease causing or neutral. With increasing use of genetic testing, and widespread clinical use of next-generation sequencing around the corner, this issue is likely to become more prominent. © 2015 John Wiley & Sons Ltd.

  20. Learned helplessness predicts functional disability, pain and fatigue in patients with recent-onset inflammatory polyarthritis

    PubMed Central

    Camacho, Elizabeth M.; Verstappen, Suzanne M. M.; Chipping, Jacqueline

    2013-01-01

    Objectives. Cross-sectional studies have found that learned helplessness (LH) is associated with disease outcome in patients with RA. However, little is known about the longitudinal impact of LH. The aim of this study was to investigate whether LH is associated with future disease outcome (disability, pain and fatigue) and to investigate whether LH changes over time in patients with recent-onset inflammatory polyarthritis (IP), the broader group of conditions of which RA is the major constituent. Methods. Patients included in this investigation had been recruited to the Norfolk Arthritis Register, a primary-care-based inception cohort. LH was measured at baseline as patients’ total score on the Rheumatology Attitudes Index (RAI). A total of 443 patients completed the HAQ and visual analogue scales of pain and fatigue at baseline and after 2 years of follow-up. Results. Greater feelings of LH at baseline were associated with higher HAQ scores at follow-up [difference in HAQ score per 1-point increase in RAI score (β-coefficient) 0.02; 95% CI 0.01, 0.04]. Greater baseline LH was also associated with more pain (β-coefficient 1.0; 95% CI 0.4, 1.5) and more fatigue (β-coefficient 1.0; 95% CI 0.2, 1.4) at follow-up. LH was highly changeable during follow-up, with 87% of patients showing any change and 50% improving. Conclusion. Baseline LH independently predicted disability, pain and fatigue at follow-up. Half of patients reported fewer feelings of helplessness after 2 years of follow-up, suggesting that LH may potentially be a modifiable risk factor for disease outcome in IP and a target for intervention. PMID:23424265

  1. Learned helplessness predicts functional disability, pain and fatigue in patients with recent-onset inflammatory polyarthritis.

    PubMed

    Camacho, Elizabeth M; Verstappen, Suzanne M M; Chipping, Jacqueline; Symmons, Deborah P M

    2013-07-01

    Cross-sectional studies have found that learned helplessness (LH) is associated with disease outcome in patients with RA. However, little is known about the longitudinal impact of LH. The aim of this study was to investigate whether LH is associated with future disease outcome (disability, pain and fatigue) and to investigate whether LH changes over time in patients with recent-onset inflammatory polyarthritis (IP), the broader group of conditions of which RA is the major constituent. Patients included in this investigation had been recruited to the Norfolk Arthritis Register, a primary-care-based inception cohort. LH was measured at baseline as patients' total score on the Rheumatology Attitudes Index (RAI). A total of 443 patients completed the HAQ and visual analogue scales of pain and fatigue at baseline and after 2 years of follow-up. Greater feelings of LH at baseline were associated with higher HAQ scores at follow-up [difference in HAQ score per 1-point increase in RAI score (β-coefficient) 0.02; 95% CI 0.01, 0.04]. Greater baseline LH was also associated with more pain (β-coefficient 1.0; 95% CI 0.4, 1.5) and more fatigue (β-coefficient 1.0; 95% CI 0.2, 1.4) at follow-up. LH was highly changeable during follow-up, with 87% of patients showing any change and 50% improving. Baseline LH independently predicted disability, pain and fatigue at follow-up. Half of patients reported fewer feelings of helplessness after 2 years of follow-up, suggesting that LH may potentially be a modifiable risk factor for disease outcome in IP and a target for intervention.

  2. Audit Report on "Protection of the Department of Energy's Unclassified Sensitive Electronic Information"

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    The Department of Energy and its contractors store and process massive quantities of sensitive information to accomplish national security, energy, science, and environmental missions. Sensitive unclassified data, such as personally identifiable information (PII), official use only, and unclassified controlled nuclear information require special handling and protection to prevent misuse of the information for inappropriate purposes. Industry experts have reported that more than 203 million personal privacy records have been lost or stolen over the past three years, including information maintained by corporations, educational institutions, and Federal agencies. The loss of personal and other sensitive information can result in substantial financialmore » harm, embarrassment, and inconvenience to individuals and organizations. Therefore, strong protective measures, including data encryption, help protect against the unauthorized disclosure of sensitive information. Prior reports involving the loss of sensitive information have highlighted weaknesses in the Department's ability to protect sensitive data. Our report on Security Over Personally Identifiable Information (DOE/IG-0771, July 2007) disclosed that the Department had not fully implemented all measures recommended by the Office of Management and Budget (OMB) and required by the National Institute of Standards and Technology (NIST) to protect PII, including failures to identify and encrypt PII maintained on information systems. Similarly, the Government Accountability Office recently reported that the Department had not yet installed encryption technology to protect sensitive data on the vast majority of laptop computers and handheld devices. Because of the potential for harm, we initiated this audit to determine whether the Department and its contractors adequately safeguarded sensitive electronic information. The Department had taken a number of steps to improve protection of PII. Our review, however

  3. Colonization potential to reconstitute a microbe community in patients detected early after fecal microbe transplant for recurrent C. difficile.

    PubMed

    Kumar, Ranjit; Maynard, Craig L; Eipers, Peter; Goldsmith, Kelly T; Ptacek, Travis; Grubbs, J Aaron; Dixon, Paula; Howard, Donna; Crossman, David K; Crowley, Michael R; Benjamin, William H; Lefkowitz, Elliot J; Weaver, Casey T; Rodriguez, J Martin; Morrow, Casey D

    2016-01-13

    Fecal microbiota transplants (FMT) are an effective treatment for patients with gut microbe dysbiosis suffering from recurrent C. difficile infections. To further understand how FMT reconstitutes the patient's gut commensal microbiota, we have analyzed the colonization potential of the donor, recipient and recipient post transplant fecal samples using transplantation in gnotobiotic mice. A total of nine samples from three human donors, recipient's pre and post FMT were transplanted into gnotobiotic mice. Microbiome analysis of three donor fecal samples revealed the presence of a high relative abundance of commensal microbes from the family Bacteriodaceae and Lachnospiraceae that were almost absent in the three recipient pre FMT fecal samples (<0.01%). The microbe composition in gnotobiotic mice transplanted with the donor fecal samples was similar to the human samples. The recipient samples contained Enterobacteriaceae, Lactobacillaceae, Enterococcaceae in relative abundance of 43, 11, 8%, respectively. However, gnotobiotic mice transplanted with the recipient fecal samples had an average relative abundance of unclassified Clostridiales of 55%, approximately 7000 times the abundance in the recipient fecal samples prior to transplant. Microbiome analysis of fecal samples from the three patients early (2-4 weeks) after FMT revealed a microbe composition with the relative abundance of both Bacteriodaceae and Lachnospiraceae that was approximately 7% of that of the donor. In contrast, gnotobioitc mice transplanted with the fecal samples obtained from the three at early times post FMT revealed increases in the relative abundance of Bacteriodaceae and Lachnospiraceae microbe compositions to levels similar to the donor fecal samples. Furthermore, the unclassified Clostridiales in the recipient samples post FMT was reduced to an average of 10%. We have used transplantation into gnotobiotic mice to evaluate the colonization potential of microbiota in FMT patients early

  4. Renal cell carcinoma, unclassified with medullary phenotype: poorly differentiated adenocarcinomas overlapping with renal medullary carcinoma.

    PubMed

    Sirohi, Deepika; Smith, Steven C; Ohe, Chisato; Colombo, Piergiuseppe; Divatia, Mukul; Dragoescu, Ema; Rao, Priya; Hirsch, Michelle S; Chen, Ying-Bei; Mehra, Rohit; Amin, Mahul B

    2017-09-01

    Renal medullary carcinoma (RMC) is a highly aggressive renal cell carcinoma arising in the collecting system and requiring careful correlation with status of sickle cell trait. A panel of international experts has recently proposed provisional diagnostic terminology, renal cell carcinoma, unclassified, with medullary phenotype, based on encountering an extraordinarily rare tumor with RMC morphology and immunophenotype in an individual proven not to have a hemoglobinopathy. Herein, we extend this observation to a cohort of 5 such tumors, morphologically similar to RMC, lacking SMARCB1 expression by immunohistochemistry, but each without evidence of a hemoglobinopathy. The tumors arose in 4 men and 1 woman with a mean age of 44 years, occurring in 3 left and 2 right kidneys. Clinically, aggression was apparent with involvement of perinephric adipose tissue in all 5 cases, nodal metastasis in 4 of 5 cases, and death of disease in 4 of 5 cases within 3-27 months. Histologic sections showed poorly differentiated adenocarcinoma, often with solid and nested growth patterns, as well as infiltrative glandular, tubulopapillary, cribriform, or reticular growth. Rhabdoid and sarcomatoid cytomorphology was seen in a subset. All tumors showed PAX8 nuclear positivity and SMARCB1 loss, with OCT3/4 expression in 4 of 5 cases. In summary, this first series of renal cell carcinoma, unclassified, with medullary phenotype documents tumors with morphologic, immunophenotypic, and prognostic features of RMC occurring in individuals without sickle cell trait. Although greater biologic and molecular understanding is needed, the available evidence points to these cases representing a sporadic counterpart to sickle cell trait-associated RMC. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Transparent Materials for Armor - A Cost Study

    DTIC Science & Technology

    2010-01-11

    UNCLASSIFIED UNCLASSIFIED Example: M1114 Recent History 2006 “Iraqi Pope Glass” 2004-2005 GPK (Gunner Protection Kit) Early OIF Curb Wt: 10,300lbs GVW...12,100lbs More Vehicles More Attacks More Glass UNCLASSIFIED UNCLASSIFIED Future Transparent Gun Shields Requirement: Upgrade GPKs with transparent...Objective AHI GS & GPK Baseline Field Modified GS & APK UNCLASSIFIED UNCLASSIFIED •Average Total ($) for transparent armor increased by about 20% (each

  6. Comparison of the efficacy of prednisone and cyclosporine for treatment of dogs with primary immune-mediated polyarthritis.

    PubMed

    Rhoades, Amy C; Vernau, William; Kass, Philip H; Herrera, Melissa A; Sykes, Jane E

    2016-02-15

    To compare efficacy between cyclosporine and prednisone for treatment of primary immune-mediated polyarthritis (IMPA) in dogs. Randomized controlled clinical trial. 20 client-owned dogs with primary IMPA. Dogs were randomly assigned to receive prednisone (starting at 1 mg/kg [0.45 mg/lb], PO, q 12 h; n = 10) or cyclosporine (5 mg/kg [2.3 mg/lb], PO, q 12 h; 10) for 90 days. Cyclosporine-treated dogs also received carprofen, tramadol, or both for the first 7 days for analgesia. Data collection, physical examination, and cytologic analysis of synovial fluid samples were performed on days 0, 14, 45, and 90. Trough whole blood cyclosporine concentrations were determined on days 7 to 17 for cyclosporine-treated dogs. Treatment failure was defined as lack of clinical improvement by day 14, lack of cytologic improvement by day 45, or need to change treatment because of adverse effects. Treatment was successful for 7 prednisone-treated dogs and 7 cyclosporine-treated dogs. Absence of synovial fluid cytologic abnormalities on day 45 was identified for 5 prednisone-treated dogs and 8 cyclosporine-treated dogs. Prednisone-treated dogs were more likely to develop polyuria, polydipsia, and polyphagia than were cyclosporine-treated dogs. Opportunistic infections (ie, demodicosis or Erysipelothrix bacteremia) were identified in 2 cyclosporine-treated dogs and 0 prednisone-treated dogs, and diarrhea developed in 1 cyclosporine-treated dog, requiring treatment discontinuation. Although the number of dogs evaluated was small, limiting generalizability, results of this study suggested that cyclosporine offers promise as a suitable alternative to prednisone for treatment of IMPA in dogs.

  7. Net Warrior D10 Technology Report: Airborne Early Warning and Control (AEW&C) and Data Link Nodes

    DTIC Science & Technology

    2012-04-01

    ADO ) approach to implementing Network Centric Warfare (NCW) through ‘learning by doing’. Net Warrior was conceived to address, through... frameworks are able to satisfy design needs of applications to produce stable mission and net centric systems. NW-D10 employed a SOA approach to...UNCLASSIFIED Net Warrior D10 Technology Report: Airborne Early Warning and Control (AEW&C) and Data Link Nodes Derek Dominish

  8. Montana SIP: Table c, (viii) Administrative Rules of Montana, Subchapter 10, Preconstruction Permit Requirements for Major Stationary Sources or Major Modifications Locating Within Attainment or Unclassified Areas

    EPA Pesticide Factsheets

    Montana SIP: Table c, (viii) Administrative Rules of Montana, Subchapter 10, Preconstruction Permit Requirements for Major Stationary Sources or Major Modifications Locating Within Attainment or Unclassified Areas

  9. Clinical features and pathological joint changes in dogs with erosive immune-mediated polyarthritis: 13 cases (2004-2012).

    PubMed

    Shaughnessy, Magen L; Sample, Susannah J; Abicht, Carter; Heaton, Caitlin; Muir, Peter

    2016-11-15

    OBJECTIVE To evaluate the clinical features and pathological joint changes in dogs with erosive immune-mediated polyarthritis (IMPA). DESIGN Retrospective case series. ANIMALS 13 dogs with erosive IMPA and 66 dogs with nonerosive IMPA. PROCEDURES The medical record database of a veterinary teaching hospital was reviewed to identify dogs with IMPA that were examined between October 2004 and December 2012. For each IMPA-affected dog, information extracted from the medical record included signalment, diagnostic test results, radiographic findings, and treatments administered. Dogs were classified as having erosive IMPA if review of radiographs revealed the presence of bone lysis in multiple joints, and descriptive data were generated for those dogs. All available direct smears of synovial fluid samples underwent cytologic evaluation. The synovial fluid total nucleated cell count and WBC differential count were estimated and compared between dogs with erosive IMPA and dogs with nonerosive IMPA. RESULTS 13 of 79 (16%) dogs had erosive IMPA. Dogs with erosive IMPA had a mean ± SD age of 7.1 ± 2.4 years and body weight of 8.3 ± 3.4 kg (18.3 ± 7.5 lb). All 13 dogs had erosive lesions in their carpal joints. The estimated median synovial fluid lymphocyte count for dogs with erosive IMPA was significantly greater than that for dogs with nonerosive IMPA. All dogs received immunosuppressive therapy with leflunomide (n = 9), prednisone (3), or prednisone-azathioprine (1). CONCLUSIONS AND CLINICAL RELEVANCE Results indicated erosive IMPA most commonly affected the carpal joints of middle-aged small-breed dogs. Further genetic analyses and analysis of lymphocyte-subsets are warranted for dogs with erosive IMPA.

  10. Clinical features and pathological joint changes in dogs with erosive immune-mediated polyarthritis: 13 cases (2004–2012)

    PubMed Central

    Shaughnessy, Magen L.; Sample, Susannah J.; Abicht, Carter; Heaton, Caitlin; Muir, Peter

    2017-01-01

    OBJECTIVE To evaluate the clinical features and pathological joint changes in dogs with erosive immune-mediated polyarthritis (IMPA). DESIGN Retrospective case series. ANIMALS 13 dogs with erosive IMPA and 66 dogs with nonerosive IMPA. PROCEDURES The medical record database of a veterinary teaching hospital was reviewed to identify dogs with IMPA that were examined between October 2004 and December 2012. For each IMPA-affected dog, information extracted from the medical record included signalment, diagnostic test results, radiographic findings, and treatments administered. Dogs were classified as having erosive IMPA if review of radiographs revealed the presence of bone lysis in multiple joints, and descriptive data were generated for those dogs. All available direct smears of synovial fluid samples underwent cytologic evaluation. The synovial fluid total nucleated cell count and WBC differential were estimated and compared between dogs with erosive IMPA and dogs with nonerosive IMPA. RESULTS 13 of 79 (16%) dogs had erosive IMPA. Dogs with erosive IMPA had a mean ± SD age of 7.1 ± 2.4 years and bodyweight of 8.3 ± 3.4 kg (18.3 ± 7.5 lb). All 13 dogs had erosive lesions in their carpal joints. The estimated median synovial fluid lymphocyte count for dogs with erosive IMPA was significantly greater than that for dogs with nonerosive IMPA. All dogs received immunosuppressive therapy with leflunomide (n = 9), prednisone (3), or prednisone-azathioprine (1). CONCLUSIONS AND CLINICAL RELEVANCE Results indicated erosive IMPA most commonly affected the carpal joints of middle-aged small-breed dogs. Further genetic analyses and analysis of lymphocyte-subsets is warranted for dogs with erosive IMPA. Word count = 256 PMID:27823373

  11. Transparent Armor Cost Benefit Study

    DTIC Science & Technology

    2008-04-01

    2005 2006 UNCLASSIFIED UNCLASSIFIED 4/30/2008 4/17 2006 “Iraqi Pope Glass” 2004-2005 - GPK Recent HistoryEarly OIF Curb Wt: 10,300lbs GVW: 12,100lbs...UNCLASSIFIED UNCLASSIFIED 4/30/2008 5/17 Future Transparent Gun Shields Requirement: Upgrade GPKS with transparent armor for enhanced situational...awareness while maintaining soldier cover within armor envelope. AHI GS & GPK Upgraded Gunner Shield – Transparent Armored Gun Shield (TAGS

  12. Transparent Armor Cost Benefit Study

    DTIC Science & Technology

    2007-03-06

    Armored HMMWVs (M1114s) 2003 2005 2006 UNCLASSIFIED UNCLASSIFIED 3/6/2007 4/17 2006 “Iraqi Pope Glass” 2004-2005 - GPK Recent HistoryEarly OIF Curb Wt...10,300lbs GVW: 12,100lbs UNCLASSIFIED UNCLASSIFIED 3/6/2007 5/17 Future Transparent Gun Shields Requirement: Upgrade GPKS with transparent armor for...enhanced situational awareness while maintaining soldier cover within armor envelope. AHI GS & GPK Upgraded Gunner Shield – Transparent Armored Gun

  13. HLA B27 typing in 511 children with juvenile idiopathic arthritis from India.

    PubMed

    Srivastava, Rajni; Phatak, Sanat; Yadav, Akhilesh; Bajpai, Preeti; Aggarwal, Amita

    2016-10-01

    The enthesitis-related arthritis (ERA) category of juvenile idiopathic arthritis (JIA) is the most common category in India. HLA B27 has a high prevalence in ERA, and ILAR classification includes it in exclusion criteria for other categories, but due to its cost, it is not routinely done. We undertook this study to assess the prevalence of HLA B27 in ERA and other groups of juvenile arthritis in India. Consecutive patients of JIA ERA and select patients from other categories were recruited from a single tertiary care hospital over a span of 3 years. HLA B27 was tested using PCR. Five hundred and eleven children were studied: 312 had ERA, and 199 had other categories (29 oligoarthritis, 107 polyarthritis, 44 systemic onset JIA, 9 psoriatic arthritis and 10 undifferentiated). The prevalence of HLA B27 was highest in the ERA group (87 %) and correlated with the presence of sacroiliitis. Prevalence was 10.3 % in oligoarthritis, 16 % in polyarticular rheumatoid factor (RF)-positive arthritis, 26 % in RF-negative polyarticular arthritis, 66 % in psoriatic arthritis and 40 % in the unclassified and 0 % in systemic onset category. Twenty-seven children had a change in category of JIA as per ILAR owing to HLA B27 testing positive, most commonly in the RF-negative polyarthritis group. Only six of these had clinical features suggestive of Spondyloarthropathy. There is high prevalence of HLA B27 in ERA. Though HLA B27 testing helps in correct classification, a minority of these patients have features suggestive of spondyloarthropathy like back pain, enthesitis or sacroiliitis.

  14. CC chemokine ligand 2 and CXC chemokine ligand 8 as neutrophil chemoattractant factors in canine idiopathic polyarthritis.

    PubMed

    Murakami, Kohei; Maeda, Shingo; Yonezawa, Tomohiro; Matsuki, Naoaki

    2016-12-01

    Canine idiopathic polyarthritis (IPA) is characterized by increased numbers of polymorphonuclear leukocytes (PMNs) in the synovial fluid (SF). In humans, CC chemokine ligand 2 (CCL2) and CXC chemokine ligand 8 (CXCL8) recruit monocytes and neutrophils, respectively, and are involved in various inflammatory disorders. The aim of this study was to assess the roles of these chemokines in driving PMNs infiltration into the joints of dogs with IPA. SF samples were collected from dogs with IPA (n=19) and healthy controls (n=8), and the concentrations of SF CCL2 and CXCL8 were determined by ELISA. Dogs with IPA had significantly higher concentrations of CCL2 (3316±2452pg/ml, mean±SD) and CXCL8 (3668±3879pg/ml) compared with the healthy controls (235±45pg/ml and <15.6pg/ml, respectively). Then, an in vitro chemotaxis assay was performed using a modified Boyden chamber (pore size: 3μm). SF from IPA dogs had a chemoattractant activity for PMNs that purified from the peripheral blood of a healthy dog. We subsequently found that combination treatment with MK-0812 (an antagonist of CCL2 receptor) and repertaxin (an antagonist of CXCL8 receptors) significantly inhibited the migration of PMNs to SF from IPA dogs. Thus, expression of the CCL2 receptor (chemokine (CC motif) receptor 2 (CCR2)) was examined using polymerase chain reaction and immunocytochemistry. Canine peripheral blood PMNs exhibited significantly higher CCR2 mRNA expression levels than those in monocytes. In addition, we observed strong CCR2 expression on PMNs obtained from healthy controls and IPA dogs, although mononuclear cells did not express CCR2. Taken together, the data suggest that CCL2 acts as a canine PMNs chemotactic factor as well as CXCL8 and both CCL2 and CXCL8 facilitate the infiltration of PMNs into the joints of dogs with IPA. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Contemporary treatment principles for early rheumatoid arthritis: a consensus statement.

    PubMed

    Kiely, Patrick D W; Brown, Andrew K; Edwards, Christopher J; O'Reilly, David T; Ostör, Andrew J K; Quinn, Mark; Taggart, Allister; Taylor, Peter C; Wakefield, Richard J; Conaghan, Philip G

    2009-07-01

    RA has a substantial impact on both patients and healthcare systems. Our objective is to advance the understanding of modern management principles in light of recent evidence concerning the condition's diagnosis and treatment. A group of practicing UK rheumatologists formulated contemporary management principles and clinical practice recommendations concerning both diagnosis and treatment. Areas of clinical uncertainty were documented, leading to research recommendations. A fundamental concept governing treatment of RA is minimization of cumulative inflammation, referred to as the inflammation-time area under the curve (AUC). To achieve this, four core principles of management were identified: (i) detect and refer patients early, even if the diagnosis is uncertain: patients should be referred at the first suspicion of persistent inflammatory polyarthritis and rheumatology departments should provide rapid access to a diagnostic and prognostic service; (ii) treat RA immediately: optimizing outcomes with conventional DMARDs and biologics requires that effective treatment be started early-ideally within 3 months of symptom onset; (iii) tight control of inflammation in RA improves outcome: frequent assessments and an objective protocol should be used to make treatment changes that maintain low-disease activity/remission at an agreed target; (iv) consider the risk-benefit ratio and tailor treatment to each patient: differing patient, disease and drug characteristics require long-term monitoring of risks and benefits with adaptations of treatments to suit individual circumstances. These principles focus on effective control of the inflammatory process in RA, but optimal uptake may require changes in service provision to accommodate appropriate care pathways.

  16. Military Training: DOD’s Annual Sustainable Ranges Report Addressed Statutory Reporting Requirements

    DTIC Science & Technology

    2015-06-01

    electromagnetic spectrum, (5) continued growth in domestic use of Unmanned Aerial Systems, (6) early coordination with renewable energy industry, and (7...unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 United States Government...challenges; (4) manage increasing military demand for range space; (5) address effects from new energy infrastructure and renewable energy effects; (6

  17. The role of goal management for successful adaptation to arthritis.

    PubMed

    Arends, Roos Y; Bode, Christina; Taal, Erik; Van de Laar, Mart A F J

    2013-10-01

    Persons with polyarthritis often experience difficulties in attaining personal goals due to disease symptoms such as pain, fatigue and reduced mobility. This study examines the relationship of goal management strategies - goal maintenance, goal adjustment, goal disengagement, goal reengagement - with indicators of adaptation to polyarthritis, namely, depression, anxiety, purpose in life, positive affect, participation, and work participation. 305 patients diagnosed with polyarthritis participated in a questionnaire study (62% female, 29% employed, mean age: 62 years). Hierarchical multiple-regression-analyses were conducted to examine the relative importance of the goal management strategies for adaptation. Self-efficacy in relation to goal management was also studied. For all adaptation indicators, the goal management strategies added substantial explained variance to the models (R(2): .07-.27). Goal maintenance and goal adjustment were significant predictors of adaptation to polyarthritis. Self-efficacy partly mediated the influence of goal management strategies. Goal management strategies were found to be important predictors of successful adaptation to polyarthritis. Overall, adjusting goals to personal ability and circumstances and striving for goals proved to be the most beneficial strategies. Designing interventions that focus on the effective management of goals may help people to adapt to polyarthritis. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  18. Universal Versus Conditional Third Day Follow-Up Visit for Children With Nonsevere Unclassified Fever at the Community Level in Ethiopia: Protocol for a Cluster Randomized Noninferiority Trial.

    PubMed

    Källander, Karin; Alfven, Tobias; Workineh, Ayalkibet Abebe; Hailemariam, Abreham; Petzold, Max; Getachew, Dawit; Barat, Lawrence; Steinhardt, Laura C; Gutman, Julie R

    2018-04-12

    Under the World Health Organization's integrated community case management strategy, febrile children seen by community health workers (on day 1) without a diagnosable illness and without danger signs are advised to return on day 3, regardless of symptom resolution. This advice might be unnecessary and place additional time and cost burdens on caregivers and community health workers. However, the safety of not following up with respect to children with unclassified fever is unknown. The objective of this study is to establish the safety of conditional follow-up of nonsevere unclassified fever, that is, nonsevere illness with fever, no malaria, pneumonia, diarrhea, or danger signs, compared with universal follow-up on day 3, through a 2-arm cluster randomized controlled noninferiority trial. The study is being conducted in 3 districts in southwest Ethiopia. A total of 25 health facilities are randomized to one of the 2 intervention arms; all 144 health posts and 284 community health workers are included. All enrolled children are followed-up after 1 week (on day 8) for re-assessment. If still sick on day 8, additional follow-up takes place after 2 weeks (day 15) and 1 month (day 29). To demonstrate that there is no significant increase in the percentage of children deteriorating clinically, the sample size needed for a noninferiority margin of 4%, a power of 80%, an alpha of 5%, and a design effect of 3 is 4284 children with unclassified fever. Main outcome is treatment failure on day 8, defined as death, hospitalization, one or more danger signs, or persistent fever. The project was funded in 2015 and enrollment was completed 2016. Data analysis is currently under way, and the first results are expected to be submitted for publication in 2018. This study addresses the question as to whether there is any benefit in recommending universal follow-up among children seen for nonsevere unclassified fever, or whether parents can be counseled to return in the event of

  19. Diagnosis of early gastric cancer using narrow band imaging and acetic acid

    PubMed Central

    Matsuo, Ken; Takedatsu, Hidetoshi; Mukasa, Michita; Sumie, Hiroaki; Yoshida, Hikaru; Watanabe, Yasutomo; Akiba, Jun; Nakahara, Keita; Tsuruta, Osamu; Torimura, Takuji

    2015-01-01

    AIM: To determine whether the endoscopic findings of depressed-type early gastric cancers (EGCs) could precisely predict the histological type. METHODS: Ninety depressed-type EGCs in 72 patients were macroscopically and histologically identified. We evaluated the microvascular (MV) and mucosal surface (MS) patterns of depressed-type EGCs using magnifying endoscopy (ME) with narrow-band imaging (NBI) (NBI-ME) and ME enhanced by 1.5% acetic acid, respectively. First, depressed-type EGCs were classified according to MV pattern by NBI-ME. Subsequently, EGCs unclassified by MV pattern were classified according to MS pattern by enhanced ME (EME) images obtained from the same angle. RESULTS: We classified the depressed-type EGCs into the following 2 MV patterns using NBI-ME: a fine-network pattern that indicated differentiated adenocarcinoma (25/25, 100%) and a corkscrew pattern that likely indicated undifferentiated adenocarcinoma (18/23, 78.3%). However, 42 of the 90 (46.7%) lesions could not be classified into MV patterns by NBI-ME. These unclassified lesions were then evaluated for MS patterns using EME, which classified 33 (81.0%) lesions as MS patterns, diagnosed as differentiated adenocarcinoma. As a result, 76 of the 90 (84.4%) lesions were matched with histological diagnoses using a combination of NBI-ME and EME. CONCLUSION: A combination of NBI-ME and EME was useful in predicting the histological type of depressed-type EGC. PMID:25632201

  20. Effectiveness of Combined Therapy with Pirfenidone and Erythromycin for Unclassifiable Interstitial Pneumonia Induced by HTLV-1-associated Bronchioloalveolar Disorder (HABA)

    PubMed Central

    Yokohori, Naoko; Sato, Akitoshi; Hasegawa, Mizue; Katsura, Hideki; Hiroshima, Kenzo; Takemura, Tamiko

    2017-01-01

    Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus involved in the pathogenesis of adult T-cell leukemia (ATL) and HTVL-1-associated bronchioloalveolar disorder (HABA). The clinical and pathological findings of HABA have been characterized as either a diffuse panbronchiolitis (DPB) pattern or idiopathic interstitial pneumonia (IIP) pattern. Treatments for HABA include corticosteroids for the IIP pattern and erythromycin for the DPB pattern. We herein report a case of HABA-associated unclassifiable interstitial pneumonia that improved with combined therapy with pirfenidone and erythromycin. This is the first report on the effectiveness of combined therapy with pirfenidone and erythromycin for HABA. PMID:28050003

  1. Unclassified mixed germ cell-sex cord-stromal tumor with multiple malignant cellular elements in a young woman: a case report and review of the literature.

    PubMed

    Pang, Shujie; Zhang, Lin; Shi, Yiquan; Liu, Yixin

    2014-01-01

    Unclassified mixed germ cell-sex cord-stromal tumor composed of germ cells and sex cord derivatives is a rare neoplasm. Approximately 10% of such tumors have malignant germ cell components. We report the case of a 28 year-old female with a right adnexal mass measuring 8 cm in greatest dimension, containing areas with both germ cell and sex cord components. The germ cell portion contained multiple growth patterns with a malignant appearance, while the sex cord element consisted mainly of annular tubules. Within the malignant germ cell elements was a dysgerminoma that accounted for approximately 75% of the tumor volume. Other malignant germ cell elements included yolk sac tumor, embryonal carcinoma, and choriocarcinoma, which comprised about 15% of the tumor volume. The annular tubule structures comprised about 10% of the total tumor volume. To our knowledge, this is the first case reported in the literature of an unclassified mixed germ cell-sex cord-stromal tumor associated with embryonal carcinoma components. The patient had a 46XX karyotype, regular menstrual periods, and no evidence of gross abnormalities in the contralateral ovary. The patient remained clinically well and disease-free 2 years after surgery. In addition to a thorough case description, the literature concerning this entity is reviewed and discussed.

  2. Loglines. November-December 2012

    DTIC Science & Technology

    2012-12-01

    and cross training, to develop new skills. “Our intent is to encourage the development of leadership traits early in an employee’s work life...aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information...18. NUMBER OF PAGES 32 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard

  3. TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding

    PubMed Central

    Naylor, Amy J.; Desanti, Guillaume; Saghir, Atif N.

    2017-01-01

    Transgenic tumour necrosis factor alpha (TNFα)-driven models of polyarthritis such as the TNFΔARE mouse have proven to be invaluable in delineating aspects of inflammatory disease pathophysiology in humans. Unfortunately, the onset of joint destruction and inflammation in these models represents a significant detriment to breeding management. We examined whether TNFα depleting therapy ‘infliximab’ might represent a significant refinement in routine breeding. Clinical scores of joint inflammation were assessed in TNFΔARE males receiving either infliximab (10 mg/kg) or saline by twice-weekly intraperitoneal injection. Joint histology and bone morphology were assessed by histological analysis and micro-computed tomography (CT), respectively. Analysis of breeding was examined retrospectively in TNFΔARE males prior to, and following, regular introduction of infliximab. Clinical scores of inflammation were significantly reduced in TNFΔARE males receiving infliximab (control 6.6 arbitrary units [AU] ± 0.88 versus infliximab 4.4 AU ± 1.4; P < 0.05), while measures of pannus invasion and bone erosion by histology and micro-CT were markedly reduced. In the breeding groups, TNFΔARE males receiving infliximab injections sired more litters over their breeding lifespan (control 1.69 ± 0.22 versus infliximab 3.00 ± 0.19; P < 0.005). Furthermore, prior to infliximab, TNFΔARE males had a 26% risk of failing to sire any litters. This was reduced to 7% after the introduction of infliximab. This study is the first to report that regular administration of infliximab is effective at suppressing disease activity and improving animal welfare in TNFΔARE animals. In addition, we have shown that infliximab is highly efficacious in improving breeding behaviour and increasing the number of litters sired by TNFΔARE males. PMID:28480797

  4. TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding.

    PubMed

    Naylor, Amy J; Desanti, Guillaume; Saghir, Atif N; Hardy, Rowan S

    2018-02-01

    Transgenic tumour necrosis factor alpha (TNFα)-driven models of polyarthritis such as the TNF ΔARE mouse have proven to be invaluable in delineating aspects of inflammatory disease pathophysiology in humans. Unfortunately, the onset of joint destruction and inflammation in these models represents a significant detriment to breeding management. We examined whether TNFα depleting therapy 'infliximab' might represent a significant refinement in routine breeding. Clinical scores of joint inflammation were assessed in TNF ΔARE males receiving either infliximab (10 mg/kg) or saline by twice-weekly intraperitoneal injection. Joint histology and bone morphology were assessed by histological analysis and micro-computed tomography (CT), respectively. Analysis of breeding was examined retrospectively in TNF ΔARE males prior to, and following, regular introduction of infliximab. Clinical scores of inflammation were significantly reduced in TNF ΔARE males receiving infliximab (control 6.6 arbitrary units [AU] ± 0.88 versus infliximab 4.4 AU ± 1.4; P < 0.05), while measures of pannus invasion and bone erosion by histology and micro-CT were markedly reduced. In the breeding groups, TNF ΔARE males receiving infliximab injections sired more litters over their breeding lifespan (control 1.69 ± 0.22 versus infliximab 3.00 ± 0.19; P < 0.005). Furthermore, prior to infliximab, TNF ΔARE males had a 26% risk of failing to sire any litters. This was reduced to 7% after the introduction of infliximab. This study is the first to report that regular administration of infliximab is effective at suppressing disease activity and improving animal welfare in TNF ΔARE animals. In addition, we have shown that infliximab is highly efficacious in improving breeding behaviour and increasing the number of litters sired by TNF ΔARE males.

  5. Loss of function IFT27 variants associated with an unclassified lethal fetal ciliopathy with renal agenesis.

    PubMed

    Quélin, Chloé; Loget, Philippe; Boutaud, Lucile; Elkhartoufi, Nadia; Milon, Joelle; Odent, Sylvie; Fradin, Mélanie; Demurger, Florence; Pasquier, Laurent; Thomas, Sophie; Attié-Bitach, Tania

    2018-04-27

    Ciliopathies comprise a group of clinically heterogeneous and overlapping disorders with a wide spectrum of phenotypes ranging from prenatal lethality to adult-onset disorders. Pathogenic variants in more than 100 ciliary protein-encoding genes have been described, most notably those involved in intraflagellar transport (IFT) which comprises two protein complexes, responsible for retrograde (IFT-A) and anterograde transport (IFT-B). Here we describe a fetus with an unclassified severe ciliopathy phenotype including short ribs, polydactyly, bilateral renal agenesis, and imperforate anus, with compound heterozygosity for c.118_125del, p.(Thr40Glyfs*11) and a c.352 +1G > T in IFT27, which encodes a small GTPase component of the IFT-B complex. We conclude that bilateral renal agenesis is a rare feature of this severe ciliopathy and this report highlights the phenotypic overlap of Pallister-Hall syndrome and ciliopathies. The phenotype in patients with IFT27 gene variants is wide ranging from Bardet-Biedl syndrome to a lethal phenotype. © 2018 Wiley Periodicals, Inc.

  6. Creation of the Driver Fixed Heel Point (FHP) CAD Accommodation Model for Military Ground Vehicle Design

    DTIC Science & Technology

    2016-08-04

    interior surfaces and direct field of view have been added per MIL-STD- 1472G. This CAD model can be applied early in the vehicle design process to ensure... interior surfaces and direct field of view have been added per MIL-STD-1472G. This CAD model can be applied early in the vehicle design process to ensure...Accommodation Model for Military Ground Vehicle Design Paper presented at 2016 NDIA/GVSETS Conference, Aug 4, 2016 4 August 2016 UNCLASSIFIED UNCLASSIFIED

  7. High Grazing Angle Sea-Clutter Literature Review

    DTIC Science & Technology

    2013-03-01

    Optimal and sub-optimal detection .................................................................... 37 7.3 Polarimetry ... polarimetry for target detection from high grazing angles. UNCLASSIFIED DSTO-GD-0736 UNCLASSIFIED 36 7.1 Parametric modelling There have not been...relationships were also found to be intrinsically related to Gaussian detection counterparts. 7.3 Polarimetry Early studies by Stacy et al. [45, 46] and

  8. Stromal cell markers are differentially expressed in the synovial tissue of patients with early arthritis.

    PubMed

    Choi, Ivy Y; Karpus, Olga N; Turner, Jason D; Hardie, Debbie; Marshall, Jennifer L; de Hair, Maria J H; Maijer, Karen I; Tak, Paul P; Raza, Karim; Hamann, Jörg; Buckley, Christopher D; Gerlag, Danielle M; Filer, Andrew

    2017-01-01

    Previous studies have shown increased expression of stromal markers in synovial tissue (ST) of patients with established rheumatoid arthritis (RA). Here, ST expression of stromal markers in early arthritis in relationship to diagnosis and prognostic outcome was studied. ST from 56 patients included in two different early arthritis cohorts and 7 non-inflammatory controls was analysed using immunofluorescence to detect stromal markers CD55, CD248, fibroblast activation protein (FAP) and podoplanin. Diagnostic classification (gout, psoriatic arthritis, unclassified arthritis (UA), parvovirus associated arthritis, reactive arthritis and RA), disease outcome (resolving vs persistent) and clinical variables were determined at baseline and after follow-up, and related to the expression of stromal markers. We observed expression of all stromal markers in ST of early arthritis patients, independent of diagnosis or prognostic outcome. Synovial expression of FAP was significantly higher in patients developing early RA compared to other diagnostic groups and non-inflammatory controls. In RA FAP protein was expressed in both lining and sublining layers. Podoplanin expression was higher in all early inflammatory arthritis patients than controls, but did not differentiate diagnostic outcomes. Stromal marker expression was not associated with prognostic outcomes of disease persistence or resolution. There was no association with clinical or sonographic variables. Stromal cell markers CD55, CD248, FAP and podoplanin are expressed in ST in the earliest stage of arthritis. Baseline expression of FAP is higher in early synovitis patients who fulfil classification criteria for RA over time. These results suggest that significant fibroblast activation occurs in RA in the early window of disease.

  9. Successful treatment with adalimumab for severe multifocal choroiditis and panuveitis in presumed (early-onset) ocular sarcoidosis.

    PubMed

    Achille, Marino; Ilaria, Pagnini; Teresa, Giani; Roberto, Caputo; Ilir, Arapi; Piergiorgio, Neri; Rolando, Cimaz; Gabriele, Simonini

    2016-02-01

    Early-onset sarcoidosis (EOS) and Blau syndrome are rare auto-inflammatory diseases characterized by a triad of skin rash, granulomatous uveitis, and symmetrical polyarthritis occurring in early childhood. In this paper, we describe a case report very interesting for the multidisciplinary management (pediatric rheumatologist and ophthalmologist), the challenging diagnosis and the difficult choice of the best treatment. We describe a case report of an 8-year old with recurrent episodes of acute uveitis that developed bilateral granulomatous panuveitis initially treated with topical and systemic steroids. Genetic testing for NOD2/CARD15 revealed a heterozygous mutation on exon 4 in the NBD domain (P268S/SNP5). Therefore, an incomplete EOS was suspected. Because uveitis worsening with multifocal chorioretinitis aggravation, intravenous boluses of methylprednisolone were administered. During the steroids tapering, she flared again, and methotrexate was started along with corticosteroids pulse therapy. However, new ocular granuloma appeared, macular oedema with poor visual outcome occurred, and therefore, adalimumab was added to MTX and steroids. After 6 months since the new therapy started, she had a complete visual recovery, and she was able to stop steroid treatment. At 2 years of follow-up, she is still in remission on treatment, and her visual acuity is normal. No side effects were observed. In our patient, we found a heterozygous mutation on exon 4 in the NBD domain (P268S/SNP5) of NOD2/CARD15 gene and an incomplete EOS was hypothesized. The role of this variant is currently under study. Adalimumab use dramatically changed the course of eye disease, prompting to stop steroid treatment and preserving visual acuity.

  10. Transparent Armor Cost Benefit Study

    DTIC Science & Technology

    2006-10-30

    added this cocoon to approximately 100 HMMWVs in Ramadi. 2006 “Iraqi Pope Glass” 2004-2005 - GPK Recent HistoryEarly OIF Curb Wt: 10,300lbs GVW...12,100lbs UNCLASSIFIED UNCLASSIFIED 10/30/2006 5/14 Future Transparent Gun Shields Requirement: Upgrade GPKS with transparent armor for enhanced...situational awareness while maintaining soldier cover within armor envelope. AHI GS & GPK Upgraded Gunner Shield – Transparent Armored Gun Shield (TAGS

  11. Previously unclassified bacteria dominate during thermophilic and mesophilic anaerobic pre-treatment of primary sludge.

    PubMed

    Pervin, Hasina M; Batstone, Damien J; Bond, Philip L

    2013-06-01

    Thermophilic biological pre-treatment enables enhanced anaerobic digestion for treatment of wastewater sludges but, at present, there is limited understanding of the hydrolytic-acidogenic microbial composition and its contribution to this process. In this study, the process was assessed by comparing the microbiology of thermophilic (50-65 °C) and mesophilic (35 °C) pre-treatment reactors treating primary sludge. A full-cycle approach for the 16S rRNA genes was applied in order to monitor the diversity of bacteria and their abundance in a thermophilic pre-treatment reactor treating primary sludge. For the thermophilic pre-treatment (TP), over 90% of the sequences were previously undetected and these had less than 97% sequence similarity to cultured organisms. During the first 83 days, members of the Betaproteobacteria dominated the community sequences and a newly designed probe was used to monitor a previously unknown bacterium affiliated with the genus Brachymonas. Between days 85 and 183, three phylotypes that affiliated with the genera Comamonas, Clostridium and Lysobacter were persistently dominant in the TP community, as revealed by terminal-restriction fragment length polymorphism (T-RFLP). Hydrolytic and fermentative functions have been speculated for these bacteria. Mesophilic pre-treatment (MP) and TP communities were different but they were both relatively dynamic. Statistical correlation analysis and the function of closely allied reference organisms indicated that previously unclassified bacteria dominated the TP community and may have been functionally involved in the enhanced hydrolytic performance of thermophilic anaerobic pre-treatment. This study is the first to reveal the diversity and dynamics of bacteria during anaerobic digestion of primary sludge. Copyright © 2013 Elsevier GmbH. All rights reserved.

  12. The counsellees' view of an unclassified variant in BRCA1/2: recall, interpretation, and impact on life.

    PubMed

    Vos, Joël; Otten, Wilma; van Asperen, Christi; Jansen, Anna; Menko, Fred; Tibben, Aad

    2008-08-01

    Unclassified variants (UVs, variants of uncertain clinical significance) are found in 13% of all BRCA1/2 mutation analyses. Little is known about the counsellees' recall and interpretation of a UV, and its psychosocial/medical impact. Retrospective semi-structured interviews with open questions and five-point Likert scales were carried out in 24 counsellees who received a UV result 3 years before (sd=1.9). Sixty-seven percent (16/24) recalled the UV result as a non-informative DNA result; 29% recalled a pathogenic result. However, 79% of all counsellees interpreted the UV result as a genetic predisposition for cancer. Variations in recall and interpretation were unexplained by demographics, cancer history of themselves and relatives, and communication aspects of UV disclosure. Sixty-seven percent perceived genetic counselling as completed, whereas 71% expected to receive new DNA information. Although most counsellees reported that UV disclosure had changed their lives in general little, one in three counsellees reported large changes in specific life domains, especially in surveillance behavior and medical decisions. Ten out of 19 participants who interpreted the UV as pathogenic had undergone preventive surgery against none of the 5 counsellees who interpreted the UV as non-informative. Counsellors and researchers need to address discrepancies between the counsellees' factual recall and their subjective interpretation of non-informative BRCA1/2-test results.

  13. Description of an as yet unclassified DNA virus from diseased Cyprinus carpio species.

    PubMed

    Hutoran, Marina; Ronen, Ariel; Perelberg, Ayana; Ilouze, Maya; Dishon, Arnon; Bejerano, Izhak; Chen, Nissim; Kotler, Moshe

    2005-02-01

    represent an as yet unclassified virus species that is endemic in C. carpio (carp).

  14. Description of an as Yet Unclassified DNA Virus from Diseased Cyprinus carpio Species

    PubMed Central

    Hutoran, Marina; Ronen, Ariel; Perelberg, Ayana; Ilouze, Maya; Dishon, Arnon; Bejerano, Izhak; Chen, Nissim; Kotler, Moshe

    2005-01-01

    represent an as yet unclassified virus species that is endemic in C. carpio (carp). PMID:15681400

  15. Selected Characteristics, Classified & Unclassified (Regular) Students; Community Colleges, Fall 1978.

    ERIC Educational Resources Information Center

    Hawaii Univ., Honolulu. Community Coll. System.

    Fall 1978 enrollment data for Hawaii's community colleges and data on selected characteristics of students enrolled in regular credit programs are presented. Of the 27,880 registrants, 74% were regular students, 1% were early admittees, 6% were registered in non-credit apprenticeship programs, and 18% were in special programs. Regular student…

  16. B Cell Lymphoma, Unclassifiable, Transformed from Follicular Lymphoma: A Rare Presentation with Review of the Literature

    PubMed Central

    Kanna, Anila; Agrawal, Swati; Jayant, Kumar; Kumar Pala, Varun; Altujjar, Mohammad; Hadid, Tarik; Khurram, Muhammad

    2015-01-01

    B cell lymphoma, unclassifiable, with features of diffuse large B cell lymphoma and classical Hodgkin's lymphoma (BCLu-DLBCL/CHL) is more commonly known as gray zone lymphoma. These cases more often present with mediastinal disease. In this report, we present a very rare case of BCLu-DLBCL/CHL without mediastinal involvement, transformed from follicular lymphoma (FL) to BCLu-DLBCL/CHL. This patient initially presented with a mass in the right neck; biopsy of the lymph node showed predominantly nodular, follicular pattern. Immunohistochemical (IHC) staining of tumor cells expressed positivity for mature B cell markers CD20, CD19, CD10, CD23, CD45, and CD38 but negative for CD5,11c. Hence, diagnosed with FL, he was given rituximab, cyclophosphamide, vincristine, and prednisone (RCVP) regimen, followed by maintenance rituximab. He showed good response. After 2 years, he presented again with a mass in the right side of the neck. Although the needle core biopsy of this mass was suggestive of B cell lymphoma, excisional biopsy showed morphological features of DLBCL as well as foci of histological pattern of CHL. IHC staining expressed positivity for CD20, CD79a, PAX5, and CD15 and CD30 consistent with DLBCL and CHL. He was diagnosed with BCLu-DLBCL/CHL. The patient received “ACVBP” (doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone) followed by radiation. BCLu-DLBCL/CHL is clinically an aggressive tumor with poorer outcomes, but our case showed complete response to ACVBP regimen with tumor regression. PMID:26380128

  17. B Cell Lymphoma, Unclassifiable, Transformed from Follicular Lymphoma: A Rare Presentation with Review of the Literature.

    PubMed

    Kanna, Anila; Agrawal, Swati; Jayant, Kumar; Kumar Pala, Varun; Altujjar, Mohammad; Hadid, Tarik; Khurram, Muhammad

    2015-01-01

    B cell lymphoma, unclassifiable, with features of diffuse large B cell lymphoma and classical Hodgkin's lymphoma (BCLu-DLBCL/CHL) is more commonly known as gray zone lymphoma. These cases more often present with mediastinal disease. In this report, we present a very rare case of BCLu-DLBCL/CHL without mediastinal involvement, transformed from follicular lymphoma (FL) to BCLu-DLBCL/CHL. This patient initially presented with a mass in the right neck; biopsy of the lymph node showed predominantly nodular, follicular pattern. Immunohistochemical (IHC) staining of tumor cells expressed positivity for mature B cell markers CD20, CD19, CD10, CD23, CD45, and CD38 but negative for CD5,11c. Hence, diagnosed with FL, he was given rituximab, cyclophosphamide, vincristine, and prednisone (RCVP) regimen, followed by maintenance rituximab. He showed good response. After 2 years, he presented again with a mass in the right side of the neck. Although the needle core biopsy of this mass was suggestive of B cell lymphoma, excisional biopsy showed morphological features of DLBCL as well as foci of histological pattern of CHL. IHC staining expressed positivity for CD20, CD79a, PAX5, and CD15 and CD30 consistent with DLBCL and CHL. He was diagnosed with BCLu-DLBCL/CHL. The patient received "ACVBP" (doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone) followed by radiation. BCLu-DLBCL/CHL is clinically an aggressive tumor with poorer outcomes, but our case showed complete response to ACVBP regimen with tumor regression.

  18. Clinical, radiological, and biochemical characteristics in patients with diseases mimicking polymyalgia rheumatica

    PubMed Central

    Yanai, Hidekatsu; Yoshida, Hiroshi; Tada, Norio

    2009-01-01

    To find out clues to differentiate between polymyalgia rheumatica (PMR) and other diseases that mimic PMR. We studied Japanese patients with PMR (n = 7), pseudogout (n = 1), remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome (n = 1), and post-infectious polyarthritis (n = 1). The distribution of inflammation in patients was evaluated using a gallium-67 scintigraphy. We measured serum C-reactive protein (CRP), matrix metalloproteinase-3 (MMP-3), and vascular endothelial growth factor (VEGF) in patients before and after treatment. Further, we compared the clinical course of PMR with that of other diseases that mimic PMR. Patients with pseudogout, RS3PE syndrome, post-infectious polyarthritis manifested similar changes in scintigraphic findings and serum CRP, MMP-3, and VEGF levels to PMR before the treatment. A significant reduction in serum CRP levels at one week after use of nonsteroidal anti-inflammatory drugs (NSAIDs) is a good clue to differentiate pseudogout and post-infectious polyarthritis from PMR. Chondrocalcinosis in the radiographs of joints is also effective to differentiate pseudogout from PMR. A small reduction of CRP levels after NSAIDs use and promptly ameliorated CRP and symptoms by a low-dose steroid therapy, which was commonly observed in patients with PMR, were also found in a patient with RS3PE syndrome. Pitting edema of the back of hands and gallium uptake in metacarpophalangeal (MCP) joints were useful to differentiate RS3PE syndrome from PMR. In conclusion, pseudogout, RS3PE syndrome, post-infectious polyarthritis should be included in the spectrum of diseases mimicking PMR. A promptly decreased serum CRP level by NSAIDs is a good clue to differentiate pseudogout and post-infectious polyarthritis from PMR. Pitting edema of the back of hands and symmetric gallium uptake in MCP joints are characteristic for RS3PE syndrome. PMID:19851514

  19. Clinical, radiological, and biochemical characteristics in patients with diseases mimicking polymyalgia rheumatica.

    PubMed

    Yanai, Hidekatsu; Yoshida, Hiroshi; Tada, Norio

    2009-01-01

    To find out clues to differentiate between polymyalgia rheumatica (PMR) and other diseases that mimic PMR. We studied Japanese patients with PMR (n = 7), pseudogout (n = 1), remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome (n = 1), and post-infectious polyarthritis (n = 1). The distribution of inflammation in patients was evaluated using a gallium-67 scintigraphy. We measured serum C-reactive protein (CRP), matrix metalloproteinase-3 (MMP-3), and vascular endothelial growth factor (VEGF) in patients before and after treatment. Further, we compared the clinical course of PMR with that of other diseases that mimic PMR. Patients with pseudogout, RS3PE syndrome, post-infectious polyarthritis manifested similar changes in scintigraphic findings and serum CRP, MMP-3, and VEGF levels to PMR before the treatment. A significant reduction in serum CRP levels at one week after use of nonsteroidal anti-inflammatory drugs (NSAIDs) is a good clue to differentiate pseudogout and post-infectious polyarthritis from PMR. Chondrocalcinosis in the radiographs of joints is also effective to differentiate pseudogout from PMR. A small reduction of CRP levels after NSAIDs use and promptly ameliorated CRP and symptoms by a low-dose steroid therapy, which was commonly observed in patients with PMR, were also found in a patient with RS3PE syndrome. Pitting edema of the back of hands and gallium uptake in metacarpophalangeal (MCP) joints were useful to differentiate RS3PE syndrome from PMR. In conclusion, pseudogout, RS3PE syndrome, post-infectious polyarthritis should be included in the spectrum of diseases mimicking PMR. A promptly decreased serum CRP level by NSAIDs is a good clue to differentiate pseudogout and post-infectious polyarthritis from PMR. Pitting edema of the back of hands and symmetric gallium uptake in MCP joints are characteristic for RS3PE syndrome.

  20. [Nutrition and chronic polyarthritis].

    PubMed

    Diethelm, U

    1993-03-23

    Patients suffering from chronic and incurable diseases often try to influence their symptoms by dietary modification. The effect of complete fasting on pain in rheumatoid arthritis is remarkable, but not fully understood. Polyunsaturated fatty-acids, specially omega-3-fatty-acids from fish oil, are significant as precursors of mediators for inflammation. In rare instances food allergy may cause or aggravate arthritis. The actual knowledge is presented in a concentrated form and some practical advice is given.

  1. Clopidogrel-Induced Recurrent Polyarthritis.

    PubMed

    Agrawal, Sahil; Harburger, Joseph; Stallings, Gary; Agrawal, Nikhil; Garg, Jalaj

    2013-01-01

    Clopidogrel is an oral thienopyridine and together with aspirin is a component of dual antiplatelet therapy for the prevention of stent thrombosis after intracoronary stent placement. The common adverse effects from its use are an increased risk of bleeding, neutropenia, and rash. Arthralgia and backache are also known to occur with its use. There have been case reports linking arthritis with the use of clopidogrel. We describe the case of a 64-year-old man who reported symptoms of fever and joint pains following initiation of therapy with clopidogrel. Acute-phase reactants were elevated. Laboratory and radiologic testing were unremarkable. Incidentally, he reported experiencing a similar arthritis after he received a loading dose of clopidogrel prior to a diagnostic coronary angiography in the past. The symptoms improved dramatically on discontinuation of clopidogrel. There was no recurrence of symptoms with prasugrel. This describes possibly the second incidence of recurrent arthritis with clopidogrel therapy.

  2. Unclassified renal cell carcinoma: a clinicopathological, comparative genomic hybridization, and whole-genome exon sequencing study.

    PubMed

    Hu, Zhen-Yan; Pang, Li-Juan; Qi, Yan; Kang, Xue-Ling; Hu, Jian-Ming; Wang, Lianghai; Liu, Kun-Peng; Ren, Yuan; Cui, Mei; Song, Li-Li; Li, Hong-An; Zou, Hong; Li, Feng

    2014-01-01

    Unclassified renal cell carcinoma (URCC) is a rare variant of RCC, accounting for only 3-5% of all cases. Studies on the molecular genetics of URCC are limited, and hence, we report on 2 cases of URCC analyzed using comparative genome hybridization (CGH) and the genome-wide human exon GeneChip technique to identify the genomic alterations of URCC. Both URCC patients (mean age, 72 years) presented at an advanced stage and died within 30 months post-surgery. Histologically, the URCCs were composed of undifferentiated, multinucleated, giant cells with eosinophilic cytoplasm. Immunostaining revealed that both URCC cases had strong p53 protein expression and partial expression of cluster of differentiation-10 and cytokeratin. The CGH profiles showed chromosomal imbalances in both URCC cases: gains were observed in chromosomes 1p11-12, 1q12-13, 2q20-23, 3q22-23, 8p12, and 16q11-15, whereas losses were detected on chromosomes 1q22-23, 3p12-22, 5p30-ter, 6p, 11q, 16q18-22, 17p12-14, and 20p. Compared with 18 normal renal tissues, 40 mutated genes were detected in the URCC tissues, including 32 missense and 8 silent mutations. Functional enrichment analysis revealed that the missense mutation genes were involved in 11 different biological processes and pathways, including cell cycle regulation, lipid localization and transport, neuropeptide signaling, organic ether metabolism, and ATP-binding cassette transporter signaling. Our findings indicate that URCC may be a highly aggressive cancer, and the genetic alterations identified herein may provide clues regarding the tumorigenesis of URCC and serve as a basis for the development of targeted therapies against URCC in the future.

  3. Unclassified renal cell carcinoma: a clinicopathological, comparative genomic hybridization, and whole-genome exon sequencing study

    PubMed Central

    Hu, Zhen-Yan; Pang, Li-Juan; Qi, Yan; Kang, Xue-Ling; Hu, Jian-Ming; Wang, Lianghai; Liu, Kun-Peng; Ren, Yuan; Cui, Mei; Song, Li-Li; Li, Hong-An; Zou, Hong; Li, Feng

    2014-01-01

    Unclassified renal cell carcinoma (URCC) is a rare variant of RCC, accounting for only 3-5% of all cases. Studies on the molecular genetics of URCC are limited, and hence, we report on 2 cases of URCC analyzed using comparative genome hybridization (CGH) and the genome-wide human exon GeneChip technique to identify the genomic alterations of URCC. Both URCC patients (mean age, 72 years) presented at an advanced stage and died within 30 months post-surgery. Histologically, the URCCs were composed of undifferentiated, multinucleated, giant cells with eosinophilic cytoplasm. Immunostaining revealed that both URCC cases had strong p53 protein expression and partial expression of cluster of differentiation-10 and cytokeratin. The CGH profiles showed chromosomal imbalances in both URCC cases: gains were observed in chromosomes 1p11-12, 1q12-13, 2q20-23, 3q22-23, 8p12, and 16q11-15, whereas losses were detected on chromosomes 1q22-23, 3p12-22, 5p30-ter, 6p, 11q, 16q18-22, 17p12-14, and 20p. Compared with 18 normal renal tissues, 40 mutated genes were detected in the URCC tissues, including 32 missense and 8 silent mutations. Functional enrichment analysis revealed that the missense mutation genes were involved in 11 different biological processes and pathways, including cell cycle regulation, lipid localization and transport, neuropeptide signaling, organic ether metabolism, and ATP-binding cassette transporter signaling. Our findings indicate that URCC may be a highly aggressive cancer, and the genetic alterations identified herein may provide clues regarding the tumorigenesis of URCC and serve as a basis for the development of targeted therapies against URCC in the future. PMID:25120763

  4. The Impact of Low-Dose Disease-modifying Anti-rheumatics Drugs (DMARDs) on Bone Mineral Density of Premenopausal Women in Early Rheumatoid Arthritis.

    PubMed

    Rexhepi, Sylejman; Rexhepi, Mjellma; Sahatçiu-Meka, Vjollca; Mahmutaj, Vigan; Boshnjaku, Shkumbin

    2016-04-01

    Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by symmetrical polyarthritis and multisystemic involvement. The aim of this study was to assess the impact of low dose of methotrexate on bone mineral density (BMD) in patients with early rheumatoid arthritis (RA). This paper follows a retrospective study, which involves 60 female patients with early onset RA diagnosed according to the American Rheumatism Association Criteria (ACR/EULAR 2010). The patients were divided into two groups group I was composed of thirty patients treated with dose of 7.5 mg/weekly methotrexate (MTX), while group II included thirty patients treated with dose of 2 g/daily sulfasalazine (SSZ). The Disease Activity was measured by a combination of Erythrocyte Sedimentation Rate (ESR) and Disease Activity Score (DAS-28). Bone mineral density of the lumbar spine (L2-4), and femoral neck, was measured by dual energy X-ray absorptiometry (DEXA) (Stratos 800). Laboratory findings included: In this study, we found no negative effect on BMD in RA patients treated with low dose MTX in comparison to patients treated with SSZ. There was not observed significant difference in BMD of the lumbar spine, femur neck or trochanter, of MTX and SSZ patients in the pretreatment phase, nor after 12 months of treatment. No significant change in the biochemical parameters of the both groups. Based on the results of our study, low dose of methotrexate has no negative effect on BMD in premenopausal RA patients. We believe that these results might provide new insights and that further longitudinal studies with larger groups of premenopausal RA patients are required.

  5. The Impact of Low-Dose Disease-modifying Anti-rheumatics Drugs (DMARDs) on Bone Mineral Density of Premenopausal Women in Early Rheumatoid Arthritis

    PubMed Central

    Rexhepi, Sylejman; Rexhepi, Mjellma; Sahatçiu-Meka, Vjollca; Mahmutaj, Vigan; Boshnjaku, Shkumbin

    2016-01-01

    Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by symmetrical polyarthritis and multisystemic involvement. Objective: The aim of this study was to assess the impact of low dose of methotrexate on bone mineral density (BMD) in patients with early rheumatoid arthritis (RA). Materials and methods: This paper follows a retrospective study, which involves 60 female patients with early onset RA diagnosed according to the American Rheumatism Association Criteria (ACR/EULAR 2010). The patients were divided into two groups group I was composed of thirty patients treated with dose of 7.5 mg/weekly methotrexate (MTX), while group II included thirty patients treated with dose of 2 g/daily sulfasalazine (SSZ). The Disease Activity was measured by a combination of Erythrocyte Sedimentation Rate (ESR) and Disease Activity Score (DAS-28). Bone mineral density of the lumbar spine (L2–4), and femoral neck, was measured by dual energy X-ray absorptiometry (DEXA) (Stratos 800). Laboratory findings included: In this study, we found no negative effect on BMD in RA patients treated with low dose MTX in comparison to patients treated with SSZ. There was not observed significant difference in BMD of the lumbar spine, femur neck or trochanter, of MTX and SSZ patients in the pretreatment phase, nor after 12 months of treatment. No significant change in the biochemical parameters of the both groups. Conclusion: Based on the results of our study, low dose of methotrexate has no negative effect on BMD in premenopausal RA patients. We believe that these results might provide new insights and that further longitudinal studies with larger groups of premenopausal RA patients are required. PMID:27147781

  6. Clinical and MRI outcome of cervical spine lesions in children with juvenile idiopathic arthritis treated with anti-TNFα drugs early in disease course.

    PubMed

    Ključevšek, Damjana; Emeršič, Nina; Toplak, Nataša; Avčin, Tadej

    2017-05-15

    The purpose of the study was to evaluate the clinical and magnetic resonance imaging (MRI) outcome of cervical spine arthritis in children with juvenile idiopathic arthritis (JIA), who received anti-TNFα early in the course of cervical spine arthritis. Medical charts and imaging of JIA patients with cervical spine involvement were reviewed in this retrospective study. Data, including age at disease onset, JIA type, disease activity, treatment and clinical outcome were collected. Initial and followup MRI examinations of cervical spine were performed according to the hospital protocol to evaluate the presence of inflammation and potential chronic/late changes. Fifteen JIA patients with MRI proved cervical spine inflammation (11 girls, 4 boys, median age 6.3y) were included in the study: 9 had polyarthritis, 3 extended oligoarthritis, 2 persistent oligoarthritis and 1 juvenile psoriatic arthritis. All children were initially treated with high-dose steroids and methotrexate. In addition, 11 patients were treated with anti-TNFα drug within 3 months, and 3 patients within 7 months of cervical spine involvement confirmed by MRI. Mean observation time was 2.9y, mean duration of anti-TNFα treatment was 2.2y. Last MRI showed no active inflammation in 12/15 children, allowing to stop biological treatment in 3 patients, and in 3/15 significant reduction of inflammation. Mild chronic changes were found on MRI in 3 children. Early treatment with anti-TNFα drugs resulted in significantly reduced inflammation or complete remission of cervical spine arthritis proved by MRI, and prevented the development of serious chronic/late changes. Repeated MRI examinations are suggested in the follow-up of JIA patients with cervical spine arthritis.

  7. [A case of Poncet's disease (tuberculous rheumatism) in a patient with chronic renal failure undergoing hemodialysis therapy].

    PubMed

    Miki, Yusuke; Fujita, Yoshiro; Kawai, Ryosuke; Danbara, Atsushi; Ueno, Yukio; Ito, Yasuhiko

    2003-10-01

    A 78-year-old man who was undergoing hemodialysis therapy was admitted to our hospital because of sore throat, remittent cervical lymphadenopathy, and polyarthritis over the preceding 4 weeks. On admission, he had bilateral cervical lymphadenopathy. He complained of arthralgia associated with tenderness, warmth and swelling of both elbows, left side wrist and left shoulder joint. The C-reactive protein level on admission was 15.3 mg/dl. Rheumatoid factor, antinuclear antibodies, tuberculin skin test and blood culture were negative. Joint fluid was not aspirated. Radiographs of the joints did not reveal any abnormalities. Acid-fast bacilli were demonstrated in the smear of the cervical lymph node with a fluorochrome rhodamine-auramine stain. Mycobacterium tuberculosis DNA was identified by polymerase chain reaction. We found the presence of caseating granuloma on the biopsy specimens and M.tuberculosis was detected from culture. At that point, we diagnosed this patient as having tuberculous lymphadenitis. His general symptoms resolved rapidly after starting with a three-drug regimen consisting of isoniazid, rifampin and pyrazinamide. His polyarthritis also improved dramatically. Finally we considered that his polyarthritis was tuberculous rheumatism, also called Poncet's disease. Poncet's disease is characterized by sterile polyarthritis during active tuberculosis infection. It is considered a reactive arthritis, which is a different entity from tuberculous arthritis. Although this is a rare disease, we should be aware of it in hemodialysis patient clinics, because the incidence of tuberculosis infection has been reported to be increasing in patients with end-stage renal failure.

  8. Evaluation of the diagnostic accuracy of hand and foot MRI for early Rheumatoid Arthritis.

    PubMed

    Nieuwenhuis, Wouter P; van Steenbergen, Hanna W; Mangnus, Lukas; Newsum, Elize C; Bloem, Johan L; Huizinga, Tom W J; le Cessie, Saskia; Reijnierse, Monique; van der Helm-van Mil, Annette H M

    2017-08-01

    To assess the diagnostic value of MRI for early RA. In some RA patients, a classifiable diagnosis cannot be made at first presentation; these patients present with unclassified arthritis (UA). The use of MRI for early diagnosis of RA is recommended, yet the evidence for its reliability is limited. MRI of hand and foot was performed in 589 early arthritis patients included in the Leiden Early Arthritis Clinic (229 presented with RA, 159 with other arthritides and 201 with UA). Symptom-free controls provided a reference for defining an abnormal MRI. In preliminary investigations, MRI of patients who presented with RA was compared with MRI of symptom-free controls and of patients with other arthritides. Thereafter, the value of MRI in early RA diagnosis was determined in UA patients using the 1-year follow-up on fulfilling the 1987 RA criteria and start of disease-modifying drugs as outcomes. Preliminary investigations were promising. Of the UA patients, 14% developed RA and 37% started disease-modifying treatment. MRI-detected tenosynovitis was associated with RA development independent of other types of MRI-detected inflammation [odds ratio (OR) = 7.5, 95% CI: 2.4, 23] and also independent of age and other inflammatory measures (swollen joints, CRP) (OR = 4.2, 95% CI: 1.4, 12.9). Within UA patients, the negative predictive value of abnormal tenosynovitis was 95% (95% CI: 89%, 98%) and the positive predictive value 25% (95% CI: 17%, 35%). The performance was best in the subgroup of UA patients presenting with oligoarthritis (18% developed RA): the positive predictive value was 36% (95% CI: 23%, 52%), the negative predictive value was 98% (95% CI: 88%, 100%), the sensitivity was 93% (95% CI: 70%, 99%) and the specificity was 63% (95% CI: 51%, 74%). MRI contributes to the identification of UA patients who will develop RA, mostly in UA patients presenting with oligoarthritis. © The Author 2017. Published by Oxford University Press on behalf of the British Society for

  9. [Seven cases of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome].

    PubMed

    Takahashi, Kozo; Fujinaga, Hiroshi; Kobayashi, Motoo; Naito, Takero; Iida, Hiroyuki; Aoki, Shuichi

    2002-11-01

    Among the elderly patients with seronegative polyarthritis, McCarty et al. (1985) proposed a disease entity of "remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome", but only a few cases have been reported in Japan. Here we report 7 cases suspicious of RS3PE syndrome, 2 men and 5 women with an average age of 75.9 years, ranging from 67-82 years. Their common findings were (1) relatively acute onset, (2) polyarthritis, (3) pitting edema of the dorsum of both hands and both feet, and (4) negative rheumatoid factor and antinuclear antibody. McCarty et al. found that RS3 PE syndrome was more prevalent in men; however, in our experience, the opposite was observed. The clinical courses of all patients were good, and they were effectively treated either by small dosages of oral prednisolone, nonsteroidal antiinflammatory drugs, or Chinese herbal (Kampo) medicines. Since this syndrome might not be rare in Japan, it seems necessary to evaluate elderly patients with seronegative polyarthritis with pitting edema as RS3PE syndrome in their routine medical examinations.

  10. Analysis of peroxidase-negative acute unclassifiable leukemias by monoclonal antibodies. 1. Acute myelogenous leukemia and acute myelomonocytic leukemia.

    PubMed

    Imamura, N; Tanaka, R; Kajihara, H; Kuramoto, A

    1988-11-01

    In this study, pretreatment peripheral and/or bone marrow blasts from 12 patients with acute unclassifiable leukemia (AUL) expressing the myeloid-related cell-surface antigen (CD 11) were isolated for further analysis. Despite a lack of myeloperoxidase (MPO) activity, 1 patient's blasts contained cytoplasmic Auer rods. The circulating blasts from another patient expressed MPO while maintaining the same surface phenotype during 20 months of clinical follow-up. In addition, the blasts from 3 cases demonstrated both myelomonocytic and monocyte-specific surface antigens, whereas the remaining 9 cases completely lacked any monocyte-specific antigen detectable by monoclonal antibodies, Mo2, My4 and Leu M3 (CD 14). The first case eventually was diagnosed as acute myelomonocytic leukemia and the second as acute myelogenous leukemia by means of immunophenotypic analysis using flow cytometry (FACS IV). In addition, the presence of MPO protein was identified in the cytoplasm of blast cells from 5 patients with AUL by means of a cytoplasmic immunofluorescence test using a monoclonal antibody (MA1). Our study indicates that non-T, non-B AUL expressing OKM1 (CD 11) antigens include acute leukemias which are unequivocally identifiable as being of either myeloid or myelomonocytic origin. However, further investigations, including immunophenotypic and cytoplasmic analysis, ultrastructural cytochemistry and gene analysis with molecular probes (tests applicable to normal myeloid cells), are necessary in order to determine the actual origin of blasts and to recognize the differentiation stages of the various types of leukemic cells from patients with undifferentiated forms of leukemia.

  11. Non-steroidal anti-inflammatory drug use does not appear to be associated with increased cardiovascular mortality in patients with inflammatory polyarthritis: results from a primary care based inception cohort of patients.

    PubMed

    Goodson, N J; Brookhart, A M; Symmons, D P M; Silman, A J; Solomon, D H

    2009-03-01

    There is controversy about the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on cardiovascular disease (CVD) mortality. The aim of this study was to explore associations between NSAID use and mortality in patients with inflammatory polyarthritis (IP). A total of 923 patients with new onset (IP), recruited to the UK Norfolk Arthritis Register (NOAR) between 1990-1994, were followed up to the end of 2004. Current medication was recorded annually for the first 6 years and then every 2-3 years. Rheumatoid factor (RF) and C-reactive protein (CRP) were measured. Logistic regression was used to calculate all cause and CVD mortality odds ratios (OR) for NSAID use at baseline and during follow-up, adjusting for gender and time-varying covariates: RF, CRP, joint counts, smoking, steroid use, DMARD use and other medication use. By 2004 there were 203 deaths, 85 due to CVD. At baseline, NSAIDs were used by 66% of patients. In final multivariate models, baseline NSAID use was inversely associated with all cause mortality (adjusted OR 0.62, 95% CI 0.45 to 0.84) and CVD mortality (adjusted OR 0.54, 95% CI 0.34 to 0.86). Interval NSAID use had weaker mortality associations: all cause mortality (adjusted OR 0.72, 95% CI 0.52 to 1.00), CVD mortality (adjusted hazard ratio (HR) 0.66, 95% CI 0.40 to 1.08). No excess CVD or all cause mortality was observed in NSAID users in this cohort of patients with IP. This is at variance with the literature relating to NSAID use in the general population. It is unclear whether this represents unmeasured confounders influencing a doctor's decision to avoid NSAIDs in the treatment of IP.

  12. Non-steroidal anti-inflammatory drug use does not appear to be associated with increased cardiovascular mortality in patients with inflammatory polyarthritis: results from a primary care based inception cohort of patients

    PubMed Central

    Goodson, N J; Brookhart, A M; Symmons, D P M; Silman, A J; Solomon, D H

    2009-01-01

    Objectives: There is controversy about the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on cardiovascular disease (CVD) mortality. The aim of this study was to explore associations between NSAID use and mortality in patients with inflammatory polyarthritis (IP). Subjects and methods: A total of 923 patients with new onset (IP), recruited to the UK Norfolk Arthritis Register (NOAR) between 1990–1994, were followed up to the end of 2004. Current medication was recorded annually for the first 6 years and then every 2–3 years. Rheumatoid factor (RF) and C-reactive protein (CRP) were measured. Logistic regression was used to calculate all cause and CVD mortality odds ratios (OR) for NSAID use at baseline and during follow-up, adjusting for gender and time-varying covariates: RF, CRP, joint counts, smoking, steroid use, DMARD use and other medication use. Results: By 2004 there were 203 deaths, 85 due to CVD. At baseline, NSAIDs were used by 66% of patients. In final multivariate models, baseline NSAID use was inversely associated with all cause mortality (adjusted OR 0.62, 95% CI 0.45 to 0.84) and CVD mortality (adjusted OR 0.54, 95% CI 0.34 to 0.86). Interval NSAID use had weaker mortality associations: all cause mortality (adjusted OR 0.72, 95% CI 0.52 to 1.00), CVD mortality (adjusted hazard ratio (HR) 0.66, 95% CI 0.40 to 1.08). Conclusion: No excess CVD or all cause mortality was observed in NSAID users in this cohort of patients with IP. This is at variance with the literature relating to NSAID use in the general population. It is unclear whether this represents unmeasured confounders influencing a doctor’s decision to avoid NSAIDs in the treatment of IP. PMID:18408253

  13. Renal Cell Carcinoma, Unclassified with Medullary Phenotype and Synchronous Renal Clear Cell Carcinoma Present in a Patient with No Sickle Cell Trait/Disease: Diagnostic and Therapeutic Challenges.

    PubMed

    Lai, Jenny Z; Lai, H Henry; Cao, Dengfeng

    2018-06-01

    Renal medullary carcinoma (RMC) is an aggressive high-grade renal cell carcinoma (RCC) associated almost exclusively with sickle cell trait or sickle cell disease. However, RCC with RMC features has rarely been reported in patients with no sickle cell trait or disease. Renal cell carcinoma unclassified with medullary phenotype (RCCU-MP) is a newly-coined term used by an international panel of experts to describe renal cell carcinoma showing morphologic and immunohistochemical features of renal medullary carcinoma in patients without sickle cell trait/disease. So far, only one study in the English literature has described five such cases. Here, we report a case with unique clinical and pathological features in a 76-year-old male patient without sickle cell trait. The patient had a history of colon cancer with liver and lung metastases and was found to have a new renal mass in his right kidney during the follow up. A right nephrectomy was performed and showed two separate masses (tumor 1 and tumor 2). Tumor 1 had histologic features of RMC and the tumor cells were positive for CK7, Pax8, and OCT4 and showed loss of nuclear INI1 expression. Tumor 1 was diagnosed as RCCU-MP (6.3 cm, pT3aNx, WHO/ISUP nuclear grade 3). Tumor 2 showed features of clear cell type of RCC (0.6 cm, pT1aNx, WHO/ISUP grade 2) with intact nuclear INI1 expression. Three-months post-nephrectomy, the patient developed lung metastasis of RCCU-MP. To the best of our knowledge, this was the first documented case with synchronous RCCU-MP and clear cell RCC presenting in a patient without sickle cell trait. Careful histologic assessment with a panel of immunohistochemical biomarkers was helpful to render a correct diagnosis for early aggressive treatment. Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  14. [Unclassified cardiomyopathy or Lyme carditis? A three year follow-up].

    PubMed

    Konopka, Marcin; Kuch, Marek; Braksator, Wojciech; Walczak, Ewa; Jakuciński, Maciej; Lipowski, Dariusz; Dłużniewski, Mirosław

    2013-01-01

    Lyme carditis can be a clinical manifestation of the early disseminated stage of Lyme disease caused by the tick-transmitted pathogen Borrelia burgdorferi. We present the case of a 41 year-old Caucasian woman referred to our hospital with symptoms of fatigue, progressive exertional dyspnoea, supraventricular cardiac arrhythmia, and an enlarged heart revealed on chest radiography. Following an untypical result of transthoracic echocardiography, cardiac magnetic resonance was performed. This showed structural cardiac changes and focus of late gadolinium enhancement in the midwall of the apex region. Further diagnostic processes, including endomyocardial biopsy and serology tests, made it possible to diagnose Lyme carditis. Clinical observation was followed-up for three years.

  15. Universal versus conditional day 3 follow-up for children with non-severe unclassified fever at the community level in Ethiopia: A cluster-randomised non-inferiority trial.

    PubMed

    Källander, Karin; Alfvén, Tobias; Funk, Tjede; Abebe, Ayalkibet; Hailemariam, Abreham; Getachew, Dawit; Petzold, Max; Steinhardt, Laura C; Gutman, Julie R

    2018-04-01

    With declining malaria prevalence and improved use of malaria diagnostic tests, an increasing proportion of children seen by community health workers (CHWs) have unclassified fever. Current community management guidelines by WHO advise that children seen with non-severe unclassified fever (on day 1) should return to CHWs on day 3 for reassessment. We compared the safety of conditional follow-up reassessment only in cases where symptoms do not resolve with universal follow-up on day 3. We undertook a 2-arm cluster-randomised controlled non-inferiority trial among children aged 2-59 months presenting with fever and without malaria, pneumonia, diarrhoea, or danger signs to 284 CHWs affiliated with 25 health centres (clusters) in Southern Nations, Nationalities, and Peoples' Region, Ethiopia. The primary outcome was treatment failure (persistent fever, development of danger signs, hospital admission, death, malaria, pneumonia, or diarrhoea) at 1 week (day 8) of follow-up. Non-inferiority was defined as a 4% or smaller difference in the proportion of treatment failures with conditional follow-up compared to universal follow-up. Secondary outcomes included the percentage of children brought for reassessment, antimicrobial prescription, and severe adverse events (hospitalisations and deaths) after 4 weeks (day 29). From December 1, 2015, to November 30, 2016, we enrolled 4,595 children, of whom 3,946 (1,953 universal follow-up arm; 1,993 conditional follow-up arm) adhered to the CHW's follow-up advice and also completed a day 8 study visit within ±1 days. Overall, 2.7% had treatment failure on day 8: 0.8% (16/1,993) in the conditional follow-up arm and 4.6% (90/1,953) in the universal follow-up arm (risk difference of treatment failure -3.81%, 95% CI -∞, 0.65%), meeting the prespecified criterion for non-inferiority. There were no deaths recorded by day 29. In the universal follow-up arm, 94.6% of caregivers reported returning for reassessment on day 3, in contrast to

  16. 40 CFR 81.354 - Northern Mariana Islands.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... Rota Municipality Unclassifiable/Attainment. Saipan Municipality Unclassifiable/Attainment. Tinian... Unclassifiable/Attainment. Rota Municipality Unclassifiable/Attainment Unclassifiable/Attainment. Saipan... Municipality Unclassifiable/Attainment. Rota Municipality Unclassifiable/Attainment. Saipan Municipality...

  17. Facts and controversies in mixed connective tissue disease.

    PubMed

    Martínez-Barrio, Julia; Valor, Lara; López-Longo, F Javier

    2018-01-12

    Mixed connective tissue disease (MCTD) is a systemic autoimmune rheumatic disease (SARD) characterised by the combination of clinical manifestations of systemic lupus erythematosus (SLE), cutaneous systemic sclerosis (SSc) and polymyositis-dermatomyositis, in the presence of elevated titers of anti-U1-RNP antibodies. Main symptoms of the disease are polyarthritis, hand oedema, Raynaud's phenomenon, sclerodactyly, myositis and oesophageal hypomobility. Although widely discussed, most authors today accept MCTD as an independent entity. Others, however, suggest that these patients may belong to subgroups or early stages of certain definite connective diseases, such as SLE or SSc, or are, in fact, SARD overlap syndromes. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  18. 40 CFR 81.315 - Indiana.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Madison County Unclassifiable/Attainment Marshall County Unclassifiable/Attainment Martin County... Unclassifiable/Attainment Martin County Unclassifiable/Attainment Miami County Unclassifiable/Attainment Monroe... Marshall County Unclassifiable/Attainment Martin County Unclassifiable/Attainment Miami County...

  19. 40 CFR 81.327 - Montana.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... County Unclassifiable/Attainment Granite County Unclassifiable/Attainment Hill County (part) excluding... Golden Valley County Unclassifiable/Attainment Granite County Unclassifiable/Attainment Hill County (part... Unclassifiable/Attainment Granite County. Unclassifiable/Attainment Hill County Unclassifiable/Attainment...

  20. 40 CFR 81.327 - Montana.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... County Unclassifiable/Attainment Granite County Unclassifiable/Attainment Hill County (part) excluding... Golden Valley County Unclassifiable/Attainment Granite County Unclassifiable/Attainment Hill County (part... Unclassifiable/Attainment Granite County. Unclassifiable/Attainment Hill County Unclassifiable/Attainment...

  1. Serum C-X-C motif chemokine 13 is elevated in early and established rheumatoid arthritis and correlates with rheumatoid factor levels

    PubMed Central

    2014-01-01

    Introduction We hypothesized that serum levels of C-X-C motif chemokine 13 (CXCL13), a B-cell chemokine, would delineate a subset of rheumatoid arthritis (RA) patients characterized by increased humoral immunity. Methods Serum from patients with established RA (the Dartmouth RA Cohort) was analyzed for CXCL13, rheumatoid factor (RF) levels, anticitrullinated peptide/protein antibody (ACPA) and total immunoglobulin G (IgG); other parameters were obtained by chart review. A confirmatory analysis was performed using samples from the Sherbrooke Early Undifferentiated PolyArthritis (EUPA) Cohort. The Wilcoxon rank-sum test, a t-test and Spearman’s correlation analysis were utilized to determine relationships between variables. Results In both the Dartmouth and Sherbrooke cohorts, CXCL13 levels were selectively increased in seropositive relative to seronegative RA patients (P = 0.0002 and P < 0.0001 for the respective cohorts), with a strong correlation to both immunoglobulin M (IgM) and IgA RF levels (P < 0.0001). There was a weaker relationship to ACPA titers (P = 0.03 and P = 0.006, respectively) and total IgG (P = 0.02 and P = 0.14, respectively). No relationship was seen with regard to age, sex, shared epitope status or inclusion high-sensitivity C-reactive protein (hsCRP) in either cohort or regarding the presence of baseline erosions in the Sherbrooke Cohort, whereas a modest relationship with Disease Activity Score in 28 joints CRP (DAS28-CRP) was seen in the Dartmouth cohort but not the Sherbrooke cohort. Conclusion Using both established and early RA cohorts, marked elevations of serum CXCL13 levels resided nearly completely within the seropositive population. CXCL13 levels exhibited a strong relationship with RF, whereas the association with clinical parameters (age, sex, DAS28-CRP and erosions) or other serologic markers (ACPA and IgG) was either much weaker or absent. Elevated serum CXCL13 levels may identify a subset of seropositive RA patients whose

  2. Cost-Effectiveness of Tight Control of Inflammation in Early Psoriatic Arthritis: Economic Analysis of a Multicenter Randomized Controlled Trial.

    PubMed

    O'Dwyer, John L; Meads, David M; Hulme, Claire T; Mcparland, Lucy; Brown, Sarah; Coates, Laura C; Moverley, Anna R; Emery, Paul; Conaghan, Philip G; Helliwell, Philip S

    2018-03-01

    Treat-to-target approaches have proved to be effective in rheumatoid arthritis, but have not been studied in psoriatic arthritis (PsA). This study was undertaken to examine the cost-effectiveness of tight control (TC) of inflammation in early PsA compared to standard care. Cost-effectiveness analyses were undertaken alongside a UK-based, open-label, multicenter, randomized controlled trial. Taking the perspective of the health care sector, effectiveness was measured using the 3-level EuroQol 5-domain, which allows for the calculation of quality-adjusted life-years (QALYs). Incremental cost-effectiveness ratios (ICERs) are presented, which represent the additional cost per QALY gained over a 48-week time horizon. Sensitivity analyses are presented assessing the impact of variations in the analytical approach and assumptions on the cost-effectiveness estimates. The mean cost and QALYs were higher in the TC group: £4,198 versus £2,000 and 0.602 versus 0.561. These values yielded an ICER of £53,948 per QALY. Bootstrapped uncertainty analysis suggests that the TC has a 0.07 probability of being cost-effective at a £20,000 threshold. Stratified analysis suggests that with certain costs being controlled, an ICER of £24,639 can be calculated for patients with a higher degree of disease severity. A tight control strategy to treat PsA is an effective intervention in the treatment pathway; however, this study does not find tight control to be cost-effective in most analyses. Lower drug prices, targeting polyarthritis patients, or reducing the frequency of rheumatology visits may improve value for money metrics in future studies. © 2017, American College of Rheumatology.

  3. 40 CFR 81.354 - Northern Mariana Islands.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Municipality Unclassifiable/Attainment. Saipan Municipality Unclassifiable/Attainment. Tinian Municipality... Unclassifiable/Attainment. Rota Municipality Unclassifiable/Attainment Unclassifiable/Attainment. Saipan...

  4. 40 CFR 81.354 - Northern Mariana Islands.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Unclassifiable/Attainment. Saipan Municipality Unclassifiable/Attainment. Tinian Municipality Unclassifiable.../Attainment. Rota Municipality Unclassifiable/Attainment Unclassifiable/Attainment. Saipan Municipality...

  5. 40 CFR 81.327 - Montana.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... County Unclassifiable/Attainment Granite County Unclassifiable/Attainment Hill County (part) excluding... Golden Valley County Unclassifiable/Attainment Granite County Unclassifiable/Attainment Hill County (part.... Golden Valley County Unclassifiable/Attainment. Granite County Unclassifiable/Attainment. Hill County...

  6. 40 CFR 81.327 - Montana.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... County Unclassifiable/Attainment Granite County Unclassifiable/Attainment Hill County (part) excluding... Golden Valley County Unclassifiable/Attainment Granite County Unclassifiable/Attainment Hill County (part.... Golden Valley County Unclassifiable/Attainment. Granite County Unclassifiable/Attainment. Hill County...

  7. 40 CFR 81.354 - Northern Mariana Islands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... Saipan Municipality Unclassifiable/Attainment. Tinian Municipality Unclassifiable/Attainment. a Includes... Municipality Unclassifiable/Attainment Unclassifiable/Attainment. Saipan Municipality Unclassifiable/Attainment...

  8. 40 CFR 81.354 - Northern Mariana Islands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... Saipan Municipality Unclassifiable/Attainment. Tinian Municipality Unclassifiable/Attainment. a Includes... Municipality Unclassifiable/Attainment Unclassifiable/Attainment. Saipan Municipality Unclassifiable/Attainment...

  9. Could early rheumatoid arthritis resolve after periodontitis treatment only?: case report and review of the literature.

    PubMed

    Salemi, Simonetta; Biondo, Michela I; Fiorentino, Chiara; Argento, Giuseppe; Paolantonio, Michele; Di Murro, Carlo; Malagnino, Vito A; Canzoni, Marco; Diamanti, Andrea Picchianti; D'Amelio, Raffaele

    2014-12-01

    Rheumatoid arthritis (RA) is an immune-mediated polyarthritis; currently no pathogenic agent has been identified as a disease trigger. A patient with RA, presumably caused by periodontal infection, whose remission has been observed after periodontitis treatment in absence of specific RA therapy, is reported here for the first time, to our knowledge. A 61-year-old male patient presented migrant arthritis associated with antibodies against citrullinated protein antigens positivity. The clinical features allowed to make RA diagnosis according to the 2010 European League against Rheumatism/American College of Rheumatology RA classification criteria. X-ray of the second upper molar showed chronic apical periodontitis. After its treatment, arthritis remission has been observed in the absence of specific RA therapy. It has been suggested that periodontitis may have a trigger role in RA pathogenesis. This could be explained by the enzymatic action of Porphyromonas gingivalis, probably leading to break tolerance to collagen. The identification and subsequent treatment of periodontitis should therefore be considered pivotal in RA prophylaxis and management.

  10. 40 CFR 81.350 - Wisconsin.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... County X Buffalo County X Chippewa County X Clark County X Crawford County X Dunn County X Eau Claire... Unclassifiable/Attainment Chippewa County Unclassifiable/Attainment Clark County Unclassifiable/Attainment... Unclassifiable/Attainment Chippewa County Unclassifiable/Attainment Clark County Unclassifiable/Attainment...

  11. 40 CFR 81.350 - Wisconsin.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... County X Buffalo County X Chippewa County X Clark County X Crawford County X Dunn County X Eau Claire... Unclassifiable/Attainment Chippewa County Unclassifiable/Attainment Clark County Unclassifiable/Attainment... Unclassifiable/Attainment Chippewa County Unclassifiable/Attainment Clark County Unclassifiable/Attainment...

  12. Shaggy Lame Fox Syndrome in Pribilof Island Arctic Foxes ( Alopex lagopus pribilofensis), Alaska.

    PubMed

    Spraker, T R; White, P A

    2017-03-01

    A previously unrecognized condition is described in wild free-ranging Pribilof arctic foxes ( Alopex lagopus pribilofensis) from the Pribilof Islands, Alaska, USA. This condition is called shaggy lame fox syndrome (SLFS) denoting the primary clinical signs first observed. Criteria used to suspect SLFS on gross examination included emaciation, failure to shed winter pelage and moderate to severe polyarthritis. Criteria used to confirm SLFS histologically included polyarthritis (characterized by lymphoplasmacytic synovitis, tenosynovitis, bursitis, periosteal bony proliferation, and periarticular lymphoplasmacytic vasculitis) and systemic leukocytoclastic vasculitis. Other histological lesions often found included renal cortical infarcts, myocarditis with myocardial infarcts, lymphoplasmacytic meningitis, lymphoplasmacytic cuffing of meningeal and a few cerebral vessels, and cavitating infarcts of the brainstem and thalamus. The cause of SLFS is not known at this time; however, the gross and histological lesions suggest that the cause of SLFS may be a bacterial polyarthritis with a secondary immune-mediated vasculitis. These lesions are consistent with changes described with Erysipelothrix rhusiopathiae in domestic dogs; E. rhusiopathiae was identified from the synovial membrane of a swollen stifle joint and the kidney from one fox using real-time polymerase chain reaction and with culture from a fox that had gross and histological lesions of SLFS. Therefore, E. rhusiopathiae is a possible etiological agent for SLFS.

  13. The clinical spectrum of remitting seronegative symmetrical synovitis with pitting edema. The Catalán Group for the Study of RS3PE.

    PubMed

    Olivé, A; del Blanco, J; Pons, M; Vaquero, M; Tena, X

    1997-02-01

    To describe the clinical and laboratory features and outcome of patients with remitting seronegative symmetrical synovitis with pitting edema (RS3PE). A retrospective multicenter study of patients with RS3PE fulfilling the following criteria: (1) bilateral pitting edema of both hands, (2) sudden onset of polyarthritis, (3) age > 50 years, (4) seronegative for rheumatoid factor (RF). 27 patients with RS3PE were included, mean age 71.7 years (58-92), 18 men (66.6%) and 9 women (33.3%). Relevant history was noted in 2 patients with polymyalgia rheumatica. Main clinical features were polyarthritis and edema of both hands. Polyarthritis involved metacarpophalangeal joints in 22 patients (81.5%), proximal interphalangeal joints in 19 (70.4%), wrists in 15 (55.5%), shoulders in 13 (48%), elbows in 3 (11.1%), knees in 9 (33.3%), and ankles in 7 (25.9%). All patients were RF negative. Antinuclear antibodies were positive at low titer in 8 patients. Erosions were present in one patient. Two patients developed T lymphoma and one myelodysplastic syndrome. RS3PE is a heterogeneous syndrome the clinical history, presence of erosions, and evolution to hematological diseases in our patients suggest that RS3PE may not be a distinct clinical entity.

  14. 40 CFR 81.350 - Wisconsin.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... County X Pepin County X Pierce County X Polk County X St. Croix County X Trempealeau County X Vernon... Unclassifiable/Attainment Ozaukee County Unclassifiable/Attainment Pepin County Unclassifiable/Attainment Pierce... Unclassifiable/Attainment Pepin County Unclassifiable/Attainment Pierce County Unclassifiable/Attainment Polk...

  15. Bi-axial Vibration Energy Harvesting

    DTIC Science & Technology

    2012-07-01

    included early dedicated portable signal averaging equipment, Nomad, CT4 and F18 fatigue test control systems and some field trials. Currently he is...and repairs to acoustically- fatigued structures. ____________________ ________________________________________________ UNCLASSIFIED...Physicists at the Tokyo Institute of Technology investigated various piezoceramic materials [20], developing lead zirconate titanate ( PZT ) in around 1952

  16. [Paraneoplastic syndromes in rheumatology].

    PubMed

    Schmalzing, Marc

    2018-05-01

    Rheumatic paraneoplastic syndromes are paraneoplastic arthritis, palmar fasciitis and polyarthritis syndrome, remitting seronegative symmetrical synovitis with pitting edema, pancreatic panniculitis with polyarthritis, paraneoplastic vasculitis, cancer-associated myositis, hypertrophic osteoarthropathy (Marie-Bamberger disease) and tumor-induced osteomalacia. Typical clinical manifestations, pathogenesis, prognosis, and treatment of this entity are presented. Knowledge of these disease entities can lead to timely diagnosis of the underlying malignant disease and to a higher probability of a cure. Response of the paraneoplastic inflammatory manifestations to corticosteroids, non-steroidal anti-inflammatory drugs or immunosuppressants is often insufficient. Curative removal of the malignant disease is crucial for the course of the paraneoplastic syndrome. When a paraneoplastic etiology of rheumatic symptoms is suspected, a step-wise diagnostic strategy is advisable.

  17. [Possibilities of differentiation of antinuclear antibodies].

    PubMed

    Müller, W; Rosenthal, M; Stojan, B

    1975-10-15

    Antinuclear antibodies can give diagnostic informations according to their titre values, the belonging to different classes of immune globulins and on the basis of different patterns of immunofluorescence connection. The determination of granulocyte-specific antibodies which frequently appear in progressive chronic polyarthritis further contributes to the differential-diagnostic classification of diseases of the connective tissue. An antibody against extractable nuclear antigen is specific for the so-called mixed connective tissue disease, an antimitochondrial antibody for the pseudo-LE-syndrome. Moreover, the own examinations resulted in a particularly high and frequent ability of complement fixation of the antinuclear factors in systematic lupus erythematosus and sclerodermy. In contrast to this in the progressive chronic polyarthritis the complement fixation was clearly more insignificant.

  18. 40 CFR 81.323 - Michigan.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Calhoun County Clinton County Eaton County Hillsdale County Ingham County Jackson County Kalamazoo County...: Calhoun County Unclassifiable/Attainment Benton Harbor Area: Berrien County Unclassifiable/Attainment... County Unclassifiable/Attainment. Branch County Unclassifiable/Attainment. Calhoun County Unclassifiable...

  19. 40 CFR 81.323 - Michigan.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Calhoun County Clinton County Eaton County Hillsdale County Ingham County Jackson County Kalamazoo County...: Calhoun County Unclassifiable/Attainment Benton Harbor Area: Berrien County Unclassifiable/Attainment... County Unclassifiable/Attainment. Branch County Unclassifiable/Attainment. Calhoun County Unclassifiable...

  20. 40 CFR 81.352 - American Samoa.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... noted. American Samoa—PM2.5 (Annual NAAQS) Designated area Designationa Date 1 Type Statewide: Eastern.../Attainment. Swains Island Unclassifiable/Attainment. Western District Unclassifiable/Attainment. a Includes...: Eastern District Unclassifiable/Attainment Unclassifiable/Attainment. Manu`a District Unclassifiable...

  1. 40 CFR 81.327 - Montana.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Unclassifiable/Attainment Granite County Unclassifiable/Attainment Hill County (part)excluding Rocky Boy Indian.../Attainment Granite County Unclassifiable/Attainment Hill County (part) excluding Rocky Boy Indian Reservation.../Attainment. Granite County Unclassifiable/Attainment. Hill County Unclassifiable/Attainment. Jefferson County...

  2. [Febrile algo-eruptive illness in a French foreign legionnaire returning from Djibouti: gonococcal arthritis].

    PubMed

    Berry, X; Oréfice, M; Jacquier, C; Saidi, R; Le Bougeant, P; Molinier, S; Morand, J J

    2010-06-01

    A French foreign legionnaire returning from Djibouti developed feverish polyarthritis with acral purpura. Diagnostic workup demonstrated gonococcemia contracted during unprotected fellatio. Based on this case report, diagnostic and therapeutic management is described.

  3. Using lifestyle factors to identify individuals at higher risk of inflammatory polyarthritis (results from the European Prospective Investigation of Cancer-Norfolk and the Norfolk Arthritis Register—the EPIC-2-NOAR Study)

    PubMed Central

    Lahiri, Manjari; Luben, Robert N; Morgan, Catharine; Bunn, Diane K; Marshall, Tarnya; Lunt, Mark; Verstappen, Suzanne M M; Symmons, Deborah P M; Khaw, Kay-Tee; Wareham, Nick; Bruce, Ian N

    2014-01-01

    Objectives To investigate the association of lifestyle factors with risk of inflammatory polyarthritis (IP) and rheumatoid arthritis (RA). Methods The European Prospective Investigation of Cancer, Norfolk, UK (EPIC-Norfolk) gathered lifestyle data from participants aged 40–79 years from 1993 to 1997. Individuals who subsequently developed IP were identified by linkage with the Norfolk Arthritis Register. A Cox proportional hazard model was developed, and a score assigned to each risk factor to calculate the odds of developing IP. Results 25 455 EPIC participants were followed for a median (IQR) of 14.2 (12.9, 15.3) years; 184 developed incident IP (138 cumulatively fulfilled criteria for RA; 107 were seropositive). Pack-years of smoking were associated with increased risk of IP and RA in men (HR 1.21 (95% CI 1.08 to 1.37) per 10-pack-years) and seropositive IP (HR 1.24 (95% CI 1.10 to 1.41)) for all. Diabetes mellitus was associated with increased risk of IP (HR 2.54 (95% CI 1.26 to 5.09)), while alcohol (HR 0.86 (95% CI 0.74 to 0.99) per unit/day) and higher social class (HR 0.36 (95% CI 0.15 to 0.89) for professionals vs manual workers) were associated with reduced risk. Body mass index was associated with seronegative IP (HR 2.75 (95% CI 1.39 to 5.46) for obese vs normal-weight participants). In women, parity (HR 2.81 (95% CI 1.37 to 5.76) for ≥2 vs no children) was associated with increased risk, and breast feeding (HR 0.66 (95% CI 0.46 to 0.94) for every 52 weeks of breast feeding) was inversely associated with risk. Risk factors from the model were used to generate a ‘risk score’. A total of 1159 (8.4%) women had scores reflecting a >3-fold increased risk of IP over those with a score of 0. Conclusions Several easily ascertained clinical and lifestyle factors can be used to stratify populations for risk of IP. PMID:23505230

  4. Biosecurity Management of Submarine Niche Areas: the Effect of Water Pressure on Biofouling Survival

    DTIC Science & Technology

    2014-01-01

    UNCLASSIFIED UNCLASSIFIED Biosecurity Management of Submarine Niche Areas: the Effect of Water Pressure on Biofouling Survival Clare...operational impacts and biosecurity risks. Approved for public release RELEASE LIMITATION UNCLASSIFIED...UNCLASSIFIED UNCLASSIFIED Biosecurity Management of Submarine Niche Areas: the Effect of Water Pressure on Biofouling Survival Executive Summary

  5. Signatures in the gut microbiota of Japanese infants who developed food allergies in early childhood.

    PubMed

    Tanaka, Masaru; Korenori, Yuki; Washio, Masakazu; Kobayashi, Takako; Momoda, Rie; Kiyohara, Chikako; Kuroda, Aki; Saito, Yuka; Sonomoto, Kenji; Nakayama, Jiro

    2017-08-01

    Bacterial colonization in infancy is considered crucial for the development of the immune system. Recently, there has been a drastic increase in childhood allergies in Japan. Therefore, we conducted a prospective study with 56 infants on the relationship between gut microbiota in the first year of life and the development of allergies during the first 3 years. In the lactation period, organic acid producers such as Leuconostoc, Weissella and Veillonella tended to be underrepresented in subjects who developed food allergies (FA, n = 14) within the first two years. In the weaning period, children in the FA group were highly colonized by unclassified Enterobacteriaceae and two Clostridium species closely related to Clostridium paraputrificum and C. tertium, and the whole tree phylogenetic diversity index was significantly lower in the FA group. All of these differences in the weaning period were statistically significant, even after adjusting for potential confounding factors. A higher abundance of unclassified Enterobacteriaceae was also found in the other allergic group (n = 15), whereas the two Clostridium species were highly specific to the FA group. The mode of action of these Clostridium species in childhood food allergies remains unknown, warranting further investigation. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. Asymptomatic natural Chlamydia pecorum infection reduces growth rates in calves by up to 48 percent

    USDA-ARS?s Scientific Manuscript database

    Intracellular Chlamydia (C.) bacteria cause in cattle some acute but rare diseases such as abortion, sporadic bovine encephalomyelitis, kerato-conjunctivitis, pneumonia, enteritis and polyarthritis. Much more frequent, essentially ubiquitous worldwide, are low-level, asymptomatic chlamydial infecti...

  7. UMD-USHbases: a comprehensive set of databases to record and analyse pathogenic mutations and unclassified variants in seven Usher syndrome causing genes.

    PubMed

    Baux, David; Faugère, Valérie; Larrieu, Lise; Le Guédard-Méreuze, Sandie; Hamroun, Dalil; Béroud, Christophe; Malcolm, Sue; Claustres, Mireille; Roux, Anne-Françoise

    2008-08-01

    Using the Universal Mutation Database (UMD) software, we have constructed "UMD-USHbases", a set of relational databases of nucleotide variations for seven genes involved in Usher syndrome (MYO7A, CDH23, PCDH15, USH1C, USH1G, USH3A and USH2A). Mutations in the Usher syndrome type I causing genes are also recorded in non-syndromic hearing loss cases and mutations in USH2A in non-syndromic retinitis pigmentosa. Usher syndrome provides a particular challenge for molecular diagnostics because of the clinical and molecular heterogeneity. As many mutations are missense changes, and all the genes also contain apparently non-pathogenic polymorphisms, well-curated databases are crucial for accurate interpretation of pathogenicity. Tools are provided to assess the pathogenicity of mutations, including conservation of amino acids and analysis of splice-sites. Reference amino acid alignments are provided. Apparently non-pathogenic variants in patients with Usher syndrome, at both the nucleotide and amino acid level, are included. The UMD-USHbases currently contain more than 2,830 entries including disease causing mutations, unclassified variants or non-pathogenic polymorphisms identified in over 938 patients. In addition to data collected from 89 publications, 15 novel mutations identified in our laboratory are recorded in MYO7A (6), CDH23 (8), or PCDH15 (1) genes. Information is given on the relative involvement of the seven genes, the number and distribution of variants in each gene. UMD-USHbases give access to a software package that provides specific routines and optimized multicriteria research and sorting tools. These databases should assist clinicians and geneticists seeking information about mutations responsible for Usher syndrome.

  8. 40 CFR 81.323 - Michigan.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Barry County Branch County Calhoun County Clinton County Eaton County Hillsdale County Ingham County... County Unclassifiable/Attainment Battle Creek Area: Calhoun County Unclassifiable/Attainment Benton.... Branch County Unclassifiable/Attainment. Calhoun County Unclassifiable/Attainment. Cass County...

  9. Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable

    MedlinePlus

    ... Myeloproliferative Neoplasms Treatment Myelodysplastic/ Myeloproliferative Neoplasms Treatment Myelodysplastic/ Myeloproliferative Neoplasms Treatment (PDQ®)–Patient Version General Information About Myelodysplastic/ ...

  10. Results of a prospective trial of mantle irradiation alone for selected patients with early-stage Hodgkin's disease.

    PubMed

    Backstrand, K H; Ng, A K; Takvorian, R W; Jones, E L; Fisher, D C; Molnar-Griffin, B J; Silver, B; Tarbell, N J; Mauch, P M

    2001-02-01

    To determine the efficacy of mantle radiation therapy alone in selected patients with early-stage Hodgkin's disease. Between October 1988 and June 2000, 87 selected patients with pathologic stage (PS) IA to IIA or clinical stage (CS) IA Hodgkin's disease were entered onto a single-arm prospective trial of treatment with mantle irradiation alone. Eighty-three of 87 patients had > or = 1 year of follow-up after completion of mantle irradiation and were included for analysis in this study. Thirty-seven patients had PS IA, 40 had PS IIA, and six had CS IA disease. Histologic distribution was as follows: nodular sclerosis (n = 64), lymphocyte predominant (n = 15), mixed cellularity (n = 3), and unclassified (n = 1). Median follow-up time was 61 months. The 5-year actuarial rates of freedom from treatment failure (FFTF) and overall survival were 86% and 100%, respectively. Eleven of 83 patients relapsed at a median time of 27 months. Nine of the 11 relapses contained at least a component below the diaphragm. All 11 patients who developed recurrent disease were alive without evidence of Hodgkin's disease at the time of last follow-up. The 5-year FFTF in the 43 stage I patients was 92% compared with 78% in the 40 stage II patients (P =.04). Significant differences in FFTF were not seen by histology (P =.26) or by European Organization for Research and Treatment of Cancer H-5F eligibility (P =.25). Mantle irradiation alone in selected patients with early-stage Hodgkin's disease is associated with disease control rates comparable to those seen with extended field irradiation. The FFTF is especially favorable among stage I patients.

  11. 40 CFR 81.304 - Arkansas.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... County Scott County Searcy County Stone County Van Buren County AQCR 022 Shreveport-Texarkana-Tyler... Van Buren County AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment Columbia... Intrastate Unclassifiable Unclassifiable. AQCR 022Shreveport-Texarkana-Tyler Interstate Unclassifiable...

  12. 40 CFR 81.304 - Arkansas.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... County Scott County Searcy County Stone County Van Buren County AQCR 022 Shreveport-Texarkana-Tyler... Van Buren County AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment Columbia... Intrastate Unclassifiable Unclassifiable. AQCR 022Shreveport-Texarkana-Tyler Interstate Unclassifiable...

  13. 40 CFR 81.304 - Arkansas.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... County Scott County Searcy County Stone County Van Buren County AQCR 022 Shreveport-Texarkana-Tyler... Van Buren County AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment Columbia... Intrastate Unclassifiable Unclassifiable. AQCR 022Shreveport-Texarkana-Tyler Interstate Unclassifiable...

  14. 40 CFR 81.304 - Arkansas.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... County Scott County Searcy County Stone County Van Buren County AQCR 022 Shreveport-Texarkana-Tyler... Van Buren County AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment Columbia... Intrastate Unclassifiable Unclassifiable. AQCR 022Shreveport-Texarkana-Tyler Interstate Unclassifiable...

  15. Ross River Virus Transmission, Infection, and Disease: a Cross-Disciplinary Review

    PubMed Central

    Harley, David; Sleigh, Adrian; Ritchie, Scott

    2001-01-01

    Ross River virus (RRV) is a fascinating, important arbovirus that is endemic and enzootic in Australia and Papua New Guinea and was epidemic in the South Pacific in 1979 and 1980. Infection with RRV may cause disease in humans, typically presenting as peripheral polyarthralgia or arthritis, sometimes with fever and rash. RRV disease notifications in Australia average 5,000 per year. The first well-described outbreak occurred in 1928. During World War II there were more outbreaks, and the name epidemic polyarthritis was applied. During a 1956 outbreak, epidemic polyarthritis was linked serologically to a group A arbovirus (Alphavirus). The virus was subsequently isolated from Aedes vigilax mosquitoes in 1963 and then from epidemic polyarthritis patients. We review the literature on the evolutionary biology of RRV, immune response to infection, pathogenesis, serologic diagnosis, disease manifestations, the extraordinary variety of vertebrate hosts, mosquito vectors, and transmission cycles, antibody prevalence, epidemiology of asymptomatic and symptomatic human infection, infection risks, and public health impact. RRV arthritis is due to joint infection, and treatment is currently based on empirical anti-inflammatory regimens. Further research on pathogenesis may improve understanding of the natural history of this disease and lead to new treatment strategies. The burden of morbidity is considerable, and the virus could spread to other countries. To justify and design preventive programs, we need accurate data on economic costs and better understanding of transmission and behavioral and environmental risks. PMID:11585790

  16. An Internet-based technique for the identification of persons with symptoms of inflammatory polyarthritis of less than 12 weeks.

    PubMed

    Liang, Matthew H; Couto, Maura C M; Duarte, Cátia C M; Gall, Victoria; White, Patience; Naides, Stanley; Schumacher, H Ralph; Hwang, Andrew S; Holers, V Michael; Deane, Kevin D; Gupta, Samar; Ho, I-Cheng; Finckh, Axel; Kopec, Jacek; Choi, Chan-Bum; Sayre, Eric C

    2015-03-01

    Identifying persons with early rheumatoid arthritis (RA) is a major challenge. The role of the Internet in making decisions about seeking care has not been studied. We developed a method for early diagnosis and referral using the Arthritis Foundation's website. A person with less than 3 months of joint pain symptom who has not yet sought medical attention was screened. Prescreened persons are linked to a self-scoring questionnaire and get a "likelihood" of RA statement. If "likely," the person is offered a free evaluation and biomarker testing performed by Quest Diagnostics. The system available only to Massachusetts's residents yielded a small steady flow of screen-positive individuals. Over 21 months, 43,244 persons took the Arthritis Foundation website prescreening questionnaire; 196 were from Massachusetts and 60 took the self-scoring algorithm. Of the 48 who screened positive, 29 set up an appointment for a free evaluation, but six never came in. Twenty-four subjects were evaluated and diagnosed independently by three rheumatologists. One met the 1987 American College of Rheumatology (ACR) criteria for RA and two met the 2010 ACR/EULAR RA criteria. The 24 examined individuals were contacted at a minimum of 1 year and asked to redo the case-finding questionnaire and asked about their health resource utilization during the interval. Seventeen of the 24 subjects responded, and 10 had seen a health professional. Three of the 17 had a diagnosis of RA; all were on at least methotrexate. Internet case finding was useful in identifying new potential RA cases. The system's performance characteristics are theoretically limited only by the number of study sites available. However, the major barrier may be that seeing a health professional is not a priority for many individuals with early symptoms.

  17. Alternate Fuel and Power in the Forward Deployed Environment

    DTIC Science & Technology

    2011-05-01

    biomass with a Carbon Footprint will do… 10 PM LAV...Global Vision - Global Mission 5/12/2011 UNCLASSIFIED UNCLASSIFIED Waste to Energy Conversion Grind...pyrolytic gasification *) and harvested as SYNGAS * Patents pending PM LAV...Global Vision - Global Mission 5/12/2011 UNCLASSIFIED UNCLASSIFIED Waste to

  18. An Evolving Digital Telecommunications Industry and Its Impact on the Operational Environment of the Nationwide Emergency Telecommunication System (NETS).

    DTIC Science & Technology

    1985-03-01

    005 4-, /nImII 1 liIm ulnli iiliiii I I UNCLASSIFIED SECURITY CLASSIFICATION OF TNIS PAGE ("on Data Bnter6t0 REPORT DOCUMENTATION PAGE READ...II different from ControllIng Office) 15. SECURITY CLASS (of thin report) Unclassified IS. OECLASSIFICATION/ DOWNGRADING SCMEDULE 1. DISTRIBUTION...EDITION OF I NOV 65 IS OBSOLETE UNCLASSIFIED N0102LF-0146601 1 UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE (When Dote wrteed) ,IA UNCLASSIFIED

  19. Operationalising United Nations Security Council Resolution 1325 within the Australian Defence Force

    DTIC Science & Technology

    2016-01-01

    Hutchinson Joint & Operations Analysis Division Defence Science and Technology Group DST- Group -GD-0909 ABSTRACT This literature...LIMITATION UNCLASSIFIED UNCLASSIFIED Published by Joint & Operations Analysis Division Defence Science and Technology Group 506 Lorimer St...This page intentionally blank UNCLASSIFIED DST- Group -GD-0909 UNCLASSIFIED Contents 1. INTRODUCTION

  20. Biotechnology on the Battlefield: An Application of Agent-based Modelling for Emerging Technology Assessment

    DTIC Science & Technology

    2015-03-01

    UNCLASSIFIED UNCLASSIFIED Biotechnology on the Battlefield: An Application of Agent-based Modelling for Emerging Technology Assessment...wounds might be treatable using advanced biotechnologies to control haemorrhaging and reduce blood-loss until medical evacuation can be completed. This...APPROVED FOR PUBLIC RELEASE UNCLASSIFIED UNCLASSIFIED Biotechnology on the Battlefield: An Application

  1. Evaluation of Future Fuels in a High Pressure Common Rail System - Part 2. 2011 Ford 6.7L Diesel Engine

    DTIC Science & Technology

    2013-01-01

    An injector needle is shown for each test in Figure 41. UNCLASSIFIED 37 UNCLASSIFIED Full Needle 60°C Ultra Low Sulfur Diesel 60°C...UNCLASSIFIED EVALUATION OF FUTURE FUELS IN A HIGH PRESSURE COMMON RAIL SYSTEM – PART 2 2011 FORD 6.7L DIESEL ENGINE INTERIM REPORT TFLRF...UNCLASSIFIED UNCLASSIFIED EVALUATION OF FUTURE FUELS IN A HIGH PRESSURE COMMON RAIL SYSTEM – PART 2 2011 FORD 6.7L DIESEL ENGINE INTERIM REPORT TFLRF

  2. Chlamydia-induced septic polyarthritis in a dog.

    PubMed

    Lambrechts, N; Picard, J; Tustin, R C

    1999-03-01

    A systemic disease associated with pyrexia, lymphadenopathy, and arthropathy of several joints of the appendicular skeleton in a dog is described. Chlamydia-like organisms were detected on light-microscopic examination of a smear made from joint fluid aspirated from one of the affected joints. A group-specific lipopolysaccharide antigen shared by all Chlamydia spp. was demonstrated by direct fluorescent antibody staining of joint fluid, which also proved positive for chlamydia by means of the relevant polymerase chain reaction test. An indirect fluorescent antibody test on serum was also positive, although the complement fixation test was negative. Attempts to grow the organism from joint aspirates in the yolk sac of embryonating hens' eggs and on appropriate tissue cultures, however, failed. Chlamydia spp. are considered to have played an aetiological role in this case, making it the first substantiated case of naturally-occurring arthropathy in a dog due to chlamydiosis. The origin of the infection could not be traced.

  3. Abortion associated with Mycoplasma bovis (M. bovis) in a bison (Bison bison) herd

    USDA-ARS?s Scientific Manuscript database

    Mycoplasma bovis (M. bovis) has recently emerged as a significant health threat in bison and is an increasing concern and source of economic loss for producers. Clinical manifestations of infection documented in bison include pneumonia, respiratory distress and polyarthritis. The current study des...

  4. Systemic mycoplasmosis with dystocia and abortion in North American bison (Bison bison) herd

    USDA-ARS?s Scientific Manuscript database

    Mycoplasma bovis has recently emerged as a significant health threat in bison and is an increasing concern and source of economic loss for producers. Clinical manifestations of infection documented in bison include pneumonia, respiratory distress and polyarthritis. The current study describes the ...

  5. Post-streptococcal reactive arthritis: where are we now

    PubMed Central

    Pathak, Himanshu; Marshall, Tarnya

    2016-01-01

    A 35-year-old man presented with polyarthritis and constitutional symptoms, and a recent history of multiple tick bites and skin rash on trekking holiday. He did not respond to oral doxycycline and cephalexine for presumed Lyme's disease. Further investigation confirmed strongly positive streptococcal serology. There was absence of clinical or echocardiography evidence of heart involvement and immunological screening for inflammatory arthritis was negative. In the absence of other major Jones criteria for acute rheumatic fever, besides polyarthritis and the serological evidence of a recent streptococcal infection, a diagnosis of post-streptococcal reactive arthritis (PSRA) was also made. He responded well to penicillin therapy and has been started on oral penicillin prophylaxis as per available guidance. As streptococcal infections in the adult population are increasingly reported, it is a timely opportunity to revisit PSRA, and develop comprehensive treatment and antibiotic prophylaxis guidelines. PMID:27520996

  6. High-G Survivability of an Unpotted Onboard Recorder

    DTIC Science & Technology

    2017-10-01

    UNCLASSIFIED UNCLASSIFIED AD-E403 949 Technical Report ARMET-TR-16081 HIGH -G SURVIVABILITY OF AN UNPOTTED ONBOARD RECORDER...Arsenal, New Jersey UNCLASSIFIED UNCLASSIFIED The views, opinions, and/or findings contained in this report are those...documentation. The citation in this report of the names of commercial firms or commercially available products or services does not constitute

  7. 2011 Precision Strike Annual Review Held in Fort Walton Beach, Florida on February 23-24, 2011

    DTIC Science & Technology

    2011-02-24

    Captain Mike Flanagan, USN Annual Review Event Chair: Erik Ballinger | International Chairs: Jim Pennock & Earle Rudolph Annual Meeting Chair...Challenges (Go-Fasts) UNCLASSIFIED UNCLASSIFIED Targeting Challenges (SPSS) SPSS Interdiction EPAC JAN 2011 UNCLASSIFIED UNCLASSIFIED Targeting...by a near- peer , or global competitor. Yesterday Dr. Huessy talked about the need for EMP hardening, are these COTS components cyber-hardened

  8. SRI PUFF 8 Computer Program for One-Dimensional Stress Wave Propagation

    DTIC Science & Technology

    1980-03-01

    raial product. UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE (Tfhen Data Entered) REPORT DOCUMENTATION PAGE READ INSTRUCTIONS BEFORE COMPLETING...EDITION OF I NOV 6S (S OBSOLETE UNCLASSIFIED SECURITY CLASSIFICATIOK OF THIS PAGE (When Data Entered) UNCLASSIFIED SECURITY CLASSIFICATION OF THIS...aspects of wave propagation calculations. UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGEfWhen Data Entered) FOREWORD This volume constitutes a

  9. Investigation of bacterial diversity in the feces of cattle fed different diets.

    PubMed

    Kim, M; Kim, J; Kuehn, L A; Bono, J L; Berry, E D; Kalchayanand, N; Freetly, H C; Benson, A K; Wells, J E

    2014-02-01

    The objective of this study is to investigate individual animal variation of bovine fecal microbiota including as affected by diets. Fecal samples were collected from 426 cattle fed 1 of 3 diets typically fed to feedlot cattle: 1) 143 steers fed finishing diet (83% dry-rolled corn, 13% corn silage, and 4% supplement), 2) 147 steers fed late growing diet (66% dry-rolled corn, 26% corn silage, and 8% supplement), and 3) 136 heifers fed early growing diet (70% corn silage and 30% alfalfa haylage). Bacterial 16S rRNA gene amplicons were determined from individual fecal samples using next-generation pyrosequencing technology. A total of 2,149,008 16S rRNA gene sequences from 333 cattle with at least 2,000 sequences were analyzed. Firmicutes and Bacteroidetes were dominant phyla in all fecal samples. At the genus level, Oscillibacter, Turicibacter, Roseburia, Fecalibacterium, Coprococcus, Clostridium, Prevotella, and Succinivibrio were represented by more than 1% of total sequences. However, numerous sequences could not be assigned to a known genus. Dominant unclassified groups were unclassified Ruminococcaceae and unclassified Lachnospiraceae that could be classified to a family but not to a genus. These dominant genera and unclassified groups differed (P < 0.001) with diets. A total of 176,692 operational taxonomic units (OTU) were identified in combination across all the 333 cattle. Only 2,359 OTU were shared across 3 diet groups. UniFrac analysis showed that bacterial communities in cattle feces were greatly affected by dietary differences. This study indicates that the community structure of fecal microbiota in cattle is greatly affected by diet, particularly between forage- and concentrate-based diets.

  10. South American plants II: taspine isolation and anti-inflammatory activity.

    PubMed

    Perdue, G P; Blomster, R N; Blake, D A; Farnsworth, N R

    1979-01-01

    Croton lechleri L. (Euphorbiaceae), a plant from the Upper Amazon Valley of Peru, yielded the alkaloid taspine. The anti-inflammatory activity of taspine hydrochloride was studied using the carrageenan-induced pedal edema method, the cotton pellet-induced granuloma method, and the adjuvant polyarthritis model.

  11. Assessment of Environmental and Occupational Health Impacts in Munitions and Weapon Systems Development: A Phased Approach

    DTIC Science & Technology

    2010-12-01

    Human Health Impacts of New Energetic Compounds. • Models – QSARs • In vitro toxicology • In vivo toxicology • Aligned with RDT&E level of...D.A.B.T. Health Effects Research Program Directorate of Toxicology Army Institute of Public Health UNCLASSIFIED Report Documentation Page Form...program. Early in the research stage models are primarily relied upon (e.g. QSAR approaches) and as the technology progresses, a greater reliance is

  12. A Preliminary Anthropometry Standard for Australian Army Equipment Evaluation

    DTIC Science & Technology

    2014-08-01

    UNCLASSIFIED Authors Mark Edwards Land Division Mark Edwards holds an undergraduate degree in Industrial Design , a Masters in Ergonomics ...equipment. Given that a built system is not a requirement of the processes described, this standard can also be used early in the design process to de...risk the design process. It must be noted that the data provided in this report are representative of the 2012 ADF Army population. The impacts

  13. Information Operations: Putting the ’I’ Back Into Dime

    DTIC Science & Technology

    2006-02-01

    Texas Early Warning Center 9. Create New York Corporate Warning Network 10. Digital Marshall Plan using residual capability in abandoned satellites... us , and that all raw information—secret, unclassified, operational, logistic—must be brought together across distributed “pits” that are able to...is overt, using methods that do not compromise the integrity or impartiality of the UN, when the information can be shared and become widely known

  14. Joint Interagency Task Force-Illicit Trafficking: Enhancing the Interagency Organizational Framework for Operations Along the Southwest Border

    DTIC Science & Technology

    2012-05-01

    established trafficking corridors: Southern California, Arizona/ Sonora , New Mexico /West Texas, and Southeast Texas. Each RCC would absorb, consolidate... Mexico , Southwest Border, Transnational Criminal Organizations Unclassified Unclassified Unclassified Unclassified UU 39 United Stales Marine Corps...and smuggle people across the border with Mexico .” —President Barack H. Obama, August 13, 20101 The United States’ (U.S.) 2,000-mile porous

  15. Shape Optimisation of Holes in Loaded Plates by Minimisation of Multiple Stress Peaks

    DTIC Science & Technology

    2015-04-01

    UNCLASSIFIED UNCLASSIFIED Shape Optimisation of Holes in Loaded Plates by Minimisation of Multiple Stress Peaks Witold Waldman and Manfred...minimising the peak tangential stresses on multiple segments around the boundary of a hole in a uniaxially-loaded or biaxially-loaded plate . It is based...RELEASE UNCLASSIFIED UNCLASSIFIED Shape Optimisation of Holes in Loaded Plates by Minimisation of Multiple Stress Peaks Executive Summary Aerospace

  16. OTH Radar Surveillance at WARF During the LRAPP Church Opal Exercise

    DTIC Science & Technology

    1976-11-01

    UNCLASSIFIED AD NUMBER ADC010483 CLASSIFICATION CHANGES TO: unclassified FROM: secret LIMITATION CHANGES TO: Approved for public release... DDC SRI STANFORD RESEARCH INSTITUTE Menlo Park, California 94025 U.S.A.D SECRET UNCLASSIFIED The views and conclusions contained in this document are...3 SRI 6-4696 DECLASSIFIED ON 31 December 2005 SECRET (This page is UNCLASSIFIED) . ... ..... .. SECRET SECURITY CLASSIFICATION OF THIS PAGE (When

  17. Detection of Brain Reorganization in Pediatric Multiple Sclerosis Using Functional MRI

    DTIC Science & Technology

    2014-10-01

    Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified Unclassified 19b. TELEPHONE NUMBER (include area code ) Standard Form 298 (Rev. 8-98...Research titled: “Passive fMRI mapping of language function for pediatric epilepsy surgery : validation using Wada, ECS, and FMAER” 2. Invited talk to...The mapping of language is important in pediatric patients who will undergo resection surgery near cortical regions essential for language function

  18. Role of Epidermal Growth Factor Receptors and Their Ligands in Normal Mammary Epithelial and Breast Cancer Cells

    DTIC Science & Technology

    1996-07-01

    UNCLASSIFIED AD NUMBER ADB216343 NEW LIMITATION CHANGE TO Approved for public release, distribution unlimited FROM Distribution authorized to U.S...PRICE CODE 17. SECURITY CLASSIFICATION 18. SECURITY CLASSIFICATION 19. SECURITY CLASSIFICATION 20. LIMITATION OF ABSTRACT OF REPORT OF THIS PAGE OF...ABSTRACT ,Unclassified Unclassified Unclassified Limited NSN 7540-01-280-5500 Standard Form 298 (Rev. 2-89) Prescribed by ANSI Std. Z39-1 8 DISCLAIMER

  19. Modeling Interferometric Structures with Birefringent Elements: A Linear Vector-Space Formalism

    DTIC Science & Technology

    2013-11-12

    Annapolis, Maryland ViNceNt J. Urick FraNk BUcholtz Photonics Technology Branch Optical Sciences Division i REPORT DOCUMENTATION PAGE Form...a Linear Vector-Space Formalism Nicholas J. Frigo,1 Vincent J. Urick , and Frank Bucholtz Naval Research Laboratory, Code 5650 4555 Overlook Avenue, SW...Annapolis, MD Unclassified Unlimited Unclassified Unlimited Unclassified Unlimited Unclassified Unlimited 29 Vincent J. Urick (202) 767-9352 Coupled mode

  20. XNDM: An Experimental Network Data Manager.

    DTIC Science & Technology

    1981-06-01

    return this copy. Retain or destroy. t t , UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE fWln Dtet Entred) READ INSTRUCTIONSREPORT DOCUMENTATION...MONITORING AGENCY NAME & AODRESS(IE’ different Irom Controlling Office) 15 SECURITY CLASS, (I this report) UNCLASSIFIED Same Is DECLASSIFICATION...DD JAN% 1473 EDITION OF I NOV 65 IS OBSOLETE UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE ("hen Date Entered) -: o . <. UNCLASSIFIED SECURITY

  1. 2005 Precision Strike Annual Programs Review

    DTIC Science & Technology

    2005-04-20

    Control Canards (4) Polyurethane Foam Support DPICM (404 M101 Grenades) Warhead Fuze: Electronic Safe & Arm Device (ESAD) UNCLASSIFIED UNCLASSIFIED PF...SYSTEMS: • JASSM: Colonel James Geurts, USAF JASSM PM • ATACMS : Colonel Earnest Harris, USA PM, Precision Fires Rockets & Missiles, PEO Space and...UNCLASSIFIED UNCLASSIFIED Viper Strike Lineage ATACMS Delivered Base BATs Viper Strike SAL Seeker Proof of Principle Demos I & II Hunter-Viper Strike

  2. COMBATXXI: Usage and Analysis at TACOM

    DTIC Science & Technology

    2011-06-20

    Prescribed by ANSI Std Z39-18 Operational Effectiveness UNCLASSIFIED UNCLASSIFIED Outline  Who We Are  Our Equipment  Our Customers  COMBATXXI Model ...Research, Development and Engineering Center Our Customers 5 Operational Effectiveness UNCLASSIFIED UNCLASSIFIED Model Overview  Combined Arms...Analysis Tool for the 21st Century (COMBATXXI) - Developed jointly by TRAC- White Sands Missle Range (WSMR) and Marine Corps Combat Development Command

  3. Unravelling the NERDS syndrome.

    PubMed

    Singh, Achintya Dinesh; Suri, Tejas Menon; Jagdish, Rakesh Kumar; Kumar, Uma

    2018-05-12

    A 22-year-old man presented with symmetric polyarthritis, pruritus and deviation of angle of mouth to the right side since the last 7 years. His symptoms were persistent despite receiving ayurvedic medications and symptomatic therapy. Examination revealed dry skin, cutaneous nodules, xanthelasma, periarticular non-tender swellings, pitting oedema of hands and feet and lower motor neuron type right facial palsy. Haematological investigations revealed eosinophilia and skin biopsy had cutaneous eosinophilic infiltration. The constellation of above findings comprises the nodules, eosinophilia, rheumatism, dermatitis and swelling syndrome. It a rare syndrome with few reported cases in literature. The patient was started on oral corticosteroids which was subsequently tapered and methotrexate therapy. His polyarthritis and skin rashes resolved with therapy. He has been followed-up for 2 years and is presently asymptomatic for the last 1 year. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  4. 40 CFR 81.319 - Louisiana.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Parish West Carroll Parish AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment... Parish AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment Avoyelles Parish... Parish Union Parish West Carroll Parish AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable...

  5. Future Directions in Tactical Vertical Lift

    DTIC Science & Technology

    2010-04-29

    The Aviation Science and Technology Challenge • OSD Future Vertical Lift • Transition to the Future AGENDA UNCLASSIFIED UNCLASSIFIED 4 Yourfilename.ppt...distributed, non-contiguous operations Joint Future Operational Environment The S&T Challenge Increased reliance on force projection by Aviation...UNCLASSIFIED UNCLASSIFIED 7 Yourfilename.ppt The S&T Challenge • “Army Aviation is the service’s most requested asset around the globe, ….. some units

  6. 40 CFR 81.319 - Louisiana.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Parish Union Parish West Carroll Parish AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable... Parish West Carroll Parish AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment...-Texarkana-Tyler Interstate Unclassifiable/Attainment Bienville Parish Bossier Parish Caddo Parish Claiborne...

  7. 40 CFR 81.319 - Louisiana.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Parish Union Parish West Carroll Parish AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable... Parish West Carroll Parish AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment...-Texarkana-Tyler Interstate Unclassifiable/Attainment Bienville Parish Bossier Parish Caddo Parish Claiborne...

  8. 40 CFR 81.344 - Texas.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-Texarkana-Tyler Interstate Unclassifiable/Attainment Anderson County Bowie County Camp County Cass County...: Victoria County Attainment AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment...-Texarkana-Tyler Interstate Unclassifiable/Attainment Anderson County Bowie County Camp County Cass County...

  9. 40 CFR 81.336 - Ohio.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... County Unclassifiable/Attainment Champaign County Unclassifiable/Attainment Clark County Unclassifiable... Attainment Dayton-Springfield Area: Clark County Attainment Greene County Attainment Miami County Attainment...-Springfield, OH: Clark County August 13, 2007 Attainment. Greene County. Miami County. Montgomery County. Lima...

  10. 40 CFR 81.319 - Louisiana.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Parish Union Parish West Carroll Parish AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable... Parish Union Parish West Carroll Parish AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable...-Texarkana-Tyler Interstate Unclassifiable/Attainment Bienville Parish Bossier Parish Caddo Parish Claiborne...

  11. 40 CFR 81.344 - Texas.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Attainment AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment Anderson County Bowie... Victoria Area: Victoria County Attainment AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable... 022Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment Anderson County Bowie County Camp County Cass...

  12. 40 CFR 81.344 - Texas.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-Texarkana-Tyler Interstate Unclassifiable/Attainment Anderson County Bowie County Camp County Cass County...: Victoria County Attainment AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment... 022Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment Anderson County Bowie County Camp County Cass...

  13. 40 CFR 81.319 - Louisiana.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Parish Union Parish West Carroll Parish AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable... Parish Union Parish West Carroll Parish AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable...-Texarkana-Tyler Interstate Unclassifiable/Attainment Bienville Parish Bossier Parish Caddo Parish Claiborne...

  14. 40 CFR 81.344 - Texas.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-Texarkana-Tyler Interstate Unclassifiable/Attainment Anderson County Bowie County Camp County Cass County...: Victoria County Attainment AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment... 022Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment Anderson County Bowie County Camp County Cass...

  15. 40 CFR 81.304 - Arkansas.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment Columbia County Hempstead... County Scott County Searcy County Stone County Van Buren County AQCR 022 Shreveport-Texarkana-Tyler... 021Northwest Arkansas Intrastate Unclassifiable Unclassifiable. AQCR 022Shreveport-Texarkana-Tyler Interstate...

  16. 40 CFR 81.323 - Michigan.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Calhoun County Clinton County Eaton County Hillsdale County Ingham County Jackson County Kalamazoo County...: Calhoun County Unclassifiable/Attainment Benton Harbor Area: Berrien County Unclassifiable/Attainment.../Attainment Jackson Area: Jackson County Unclassifiable/Attainment Kalamazoo-Battle Creek, MI: Calhoun County...

  17. 40 CFR 81.301 - Alabama.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... County Barbour County Bibb County Blount County Bullock County Butler County Calhoun County Chambers... County Calhoun County Chambers County Cherokee County Chilton County Choctaw County Clarke County Clay... Unclassifiable/Attainment. Butler County Unclassifiable/Attainment. Calhoun County Unclassifiable/Attainment...

  18. Humoral immune response against two surface antigens of Chlamydia pecorum in vaccinated and naturally infected sheep.

    PubMed

    Bommana, Sankhya; Walker, Evelyn; Desclozeaux, Marion; Timms, Peter; Polkinghorne, Adam

    2017-01-01

    Chlamydia pecorum is a globally recognised livestock pathogen due to the significant clinical and economic impact it poses to livestock producers. Routine serological diagnosis is through a complement fixation test (CFT), which is often criticised for cross-reactivity, poor sensitivity and specificity. Although serology remains the preferred method in veterinary diagnostic laboratories, serological assays based on surface antigens of C. pecorum have not been established until now. In this study, we evaluated the use of two chlamydial recombinant protein antigens (PmpG and MOMP-G) by a direct IgG ELISA method for detection of ovine anti-chlamydial antibodies. Using the Pepscan method we then identified B cell epitopes across PmpG and MOMP-G proteins, in lambs with (a) naturally occurring asymptomatic C. pecorum infections (b) C. pecorum-associated polyarthritis and (c) recombinant PmpG and MOMP-G vaccine. Plasma IgG antibodies to PmpG in natural infection of lambs were detected earlier in infection than CFT and served as an acute phase marker. Antibodies to MOMP-G IgG were significantly heightened in lambs with C. pecorum-associated polyarthritis. PmpG and MOMP-G specific B-cell epitope mapping revealed epitope responses in immunised lambs cluster with some of the epitope responses in naturally infected lambs. B-cell epitope mapping further revealed that lambs with polyarthritis recognised several unique PmpG (50% frequency, peptide 8, 25, 40, 41 and 50) and MOMP (50% frequency, peptide 50) epitopes in comparison to asymptomatic infections. The findings of this study will have implications towards improved serodiagnosis of C. pecorum infections in livestock and inform the downstream development of alternative peptide-based antigens for future C. pecorum vaccine studies.

  19. 14 CFR 1203.302 - Combination, interrelation or compilation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... INFORMATION SECURITY PROGRAM Classification Principles and Considerations § 1203.302 Combination.... Compilations of unclassified information are considered unclassified unless some additional significant factor is added in the process of compilation. For example: (a) The way unclassified information is compiled...

  20. 14 CFR 1203.302 - Combination, interrelation or compilation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INFORMATION SECURITY PROGRAM Classification Principles and Considerations § 1203.302 Combination.... Compilations of unclassified information are considered unclassified unless some additional significant factor is added in the process of compilation. For example: (a) The way unclassified information is compiled...

  1. Ethnic Violence, Impact on Afghanistan

    DTIC Science & Technology

    2011-04-08

    OF RESPONSIBLE PERSON a. REPORT UNCLASSIFIED b. ABSTRACT UNCLASSIFIED c . THIS PAGE UNCLASSIFIED UNLIMITED 34 19b. TELEPHONE NUMBER... Zirak (Popalzai, Alikozai, Barkzai and Achalzai) and the Panjpao (Nurzai, Alizai, and Ishaqzai). Additional claims of descent include the Yusefzai

  2. 40 CFR 81.344 - Texas.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-Texarkana-Tyler Interstate Unclassifiable/Attainment Anderson County Bowie County Camp County Cass County... Victoria Area: Victoria County Attainment AQCR 022 Shreveport-Texarkana-Tyler Interstate Unclassifiable... 022Shreveport-Texarkana-Tyler Interstate Unclassifiable/Attainment Anderson County Bowie County Camp County Cass...

  3. Testing ER-Beta Agonist Synergy with B7-H1 and mTOR Inhibitors as Novel and Effective Treatments for Ovarian Cancer

    DTIC Science & Technology

    2016-08-01

    other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a...RESPONSIBLE PERSON USAMRMC a. REPORT Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified Unclassified 19b. TELEPHONE...alter tumor growth when given 7 days after tumor challenge. When we added αB7-H1 to LY, we got a borderline significant improvement in survival in

  4. Development of a Low Strain-Rate Gun Propellant Bed Compression Test and its Use in Evaluating Mechanical Response

    DTIC Science & Technology

    2016-09-01

    heuristics, die and propellant geometries from similar facilities reported in the literature [2,3] and the DST Group design .  bed* (mm) φbed...compliance curves from the experimental data. In UNCLASSIFIED DST- Group -TR-3291 UNCLASSIFIED 18 Figure 13, the red axial compliance traces were...UNCLASSIFIED DST- Group -TR-3291 UNCLASSIFIED 46 At a test temperature of -60˚C, the equivalent strain rates are within the 10 to 500 s-1 given in

  5. Blast Mitigation Sea Analysis - Evaluation of Lumbar Compression Data Trends in 5th Percentile Female Anthropomorphic Test Device Performance Compared to 50th Percentile Male Anthropomorphic Test Device in Drop Tower Testing

    DTIC Science & Technology

    2016-08-21

    less pronounced for pelvis velocity • Seat velocity and dynamic displacement not recorded for this test series – Would provide key information for...effectiveness of seat – Displacement /time history data should be recorded for all future test series UNCLASSIFIED UNCLASSIFIED Conclusions/Future...interfacing with seat manufacturers to broaden occupant protection range – Record dynamic stroke on all drop tower tests to evaluate correlation between displacement rate and lumbar compression UNCLASSIFIED UNCLASSIFIED 17

  6. Unclassified/Unlimited AD Document Index.

    DTIC Science & Technology

    1985-12-01

    405369 405521 405645 405726 404917 404997 405100 405205 405387 405525 405648 405727 404918 405000 405101 405206 405389 405532 405647 405728 404919 405001...405102 405207 405394 405534 405648 405730 404920 405002 405103 405208 405407 405535 405649 405735 404921 405003 405106 405209 405415 405539 405650

  7. 40 CFR 81.302 - Alaska.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Fairbanks N. Star Borough Area other than portion of Fairbanks urban area designated Nonattainment Kobuk... Unclassifiable/Attainment Denali Borough Fairbanks North Star Borough Nome Census Area North Slope Borough... Alaska Intrastate: Denali Borough Unclassifiable/Attainment. Fairbanks North Star Borough Unclassifiable...

  8. 40 CFR 81.302 - Alaska.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Fairbanks N. Star Borough Area other than portion of Fairbanks urban area designated Nonattainment Kobuk... Unclassifiable/Attainment Denali Borough Fairbanks North Star Borough Nome Census Area North Slope Borough... Star Borough Unclassifiable/Attainment. Nome Census Area Unclassifiable/Attainment. North Slope Borough...

  9. 40 CFR 81.336 - Ohio.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... County Unclassifiable/Attainment Champaign County Unclassifiable/Attainment Clark County Unclassifiable... intersection of Interstate 71 and Clark Avenue to the intersection of Interstate 77 and Pershing Avenue Rest of... Dayton-Springfield Area: Clark County Attainment Greene County Attainment Miami County Attainment...

  10. 40 CFR 81.316 - Iowa.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Buchanan County Buena Vista County Butler County Calhoun County Carroll County Cass County Cedar County... Buchanan County Buena Vista County Butler County Calhoun County Carroll County Cass County Cedar County... Unclassifiable/Attainment. Calhoun County Unclassifiable/Attainment. Carroll County Unclassifiable/Attainment...

  11. 40 CFR 81.316 - Iowa.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Buchanan County Buena Vista County Butler County Calhoun County Carroll County Cass County Cedar County... Buchanan County Buena Vista County Butler County Calhoun County Carroll County Cass County Cedar County... Unclassifiable/Attainment. Calhoun County Unclassifiable/Attainment. Carroll County Unclassifiable/Attainment...

  12. The Effect of Substrate Emissivity on the Spectral Emission of a Hot-Gas Overlayer

    DTIC Science & Technology

    2015-12-30

    unlimited. Unclassified Unlimited Unclassified Unlimited Unclassified Unlimited Unclassified Unlimited 19 Harold D. Ladouceur (202) 767-3558 Fourier ...13 REFERENCES………………………………………………………………………………….………..14 E-1 EXECUTIVE SUMMARY Fourier transform infrared...Raman spectroscopy, ambient x-ray photoelectron spectroscopy, near- infrared thermal imaging, and Fourier transform infrared emission spectroscopy

  13. Junior Leader Training Development in Operational Units

    DTIC Science & Technology

    2012-04-01

    ABSTRACT Same as Report (SAR) 18 . NUMBER OF PAGES 38 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS...PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39- 18 U.S. Army Research Institute for the Behavioral and Social...ad r development, training development, 8-step training model, opera · nat un· • training job a· s 16. REPORT Unclassified 17. ABSTAACT 18 . THIS

  14. The Mechanical Metallurgy of Armour Steels

    DTIC Science & Technology

    2016-10-01

    Group -TR-3305 UNCLASSIFIED 7 Figure 5: Linear relationship between quasi -static tensile yield stress and ballistic limit...te d Ba lli st ic L im it (m /s ) Experimental Ballistic Limit (m/s) UNCLASSIFIED DST- Group -TR-3305 UNCLASSIFIED 9 flow stress with strain...1000 1500 2000 2500 3000 0 0.2 0.4 0.6 0.8 Tr ue S tr es s (M Pa ) True Strain Quasi -static Dynamic RHA HHA UHHA UNCLASSIFIED DST- Group

  15. 78 FR 11572 - Airworthiness Directives; Pilatus Aircraft Ltd. Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... Revision No. 04-03, dated October 15, 2012, which transmits Unclassified 12-A/AMP-04 ``STRUCTURAL... October 15, 2012, which transmits Unclassified 12-B/AMP-04 ``STRUCTURAL AND COMPONENT LIMITATIONS... Unclassified 12-A/AMP-04 ``STRUCTURAL, COMPONENT AND MISCELLANEOUS--AIRWORTHINESS LIMITATIONS,'' document 12-A...

  16. Epitrochoid Power-law Nozzle Concept for Reducing Launch Architecture Propulsion Costs

    DTIC Science & Technology

    2010-11-16

    19a. NAME OF RESPONSIBLE PERSON Mr. Roy Hilton a. REPORT Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified SAR 15 19b...ACKNOWLEDGMENTS Mr. Paulson thanks his colleagues at AFRURZS for their input during the development of the EPN concept, in particular Messrs. Jason

  17. 40 CFR 81.315 - Indiana.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Unclassifiable/Attainment Cass County Unclassifiable/Attainment Clark County Unclassifiable/Attainment Clay...: Vanderburgh County Attainment Indianapolis Area: Marion County Attainment Louisville Area: Clark County 10/23... LaPorte CO., IN: LaPorte County 7/19/07 Attainment. Louisville, KY-IN: Clark County. Floyd County July 19...

  18. 40 CFR 81.315 - Indiana.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Unclassifiable/Attainment Cass County Unclassifiable/Attainment Clark County Unclassifiable/Attainment Clay...: Vanderburgh County Attainment Indianapolis Area: Marion County Attainment Louisville Area: Clark County 10/23... LaPorte CO., IN: LaPorte County 7/19/07 Attainment. Louisville, KY-IN: Clark County. Floyd County July 19...

  19. On Directional Selectivity in Vertebrate Retina: An Experimental and Computational Study

    DTIC Science & Technology

    1992-01-01

    Borg-Graham MIT Artificial Intelligence Laboratory Approved for public re•l•:sl i istzibu4 93-01232 98 1. 2 114- REPORT DOCUMENTATION PAGE OM[ B o J1...PAGE OF ABSTRACT UNCLASSIFIED UNCLASSIFIED UNCLASSIFIED UNCLASSIFIED %S .4 _ ýB-. u5%Q (*j Block 13 continued: preparation and b ) a whole-cell patch...currents and b ) by re- moving ATP from the electrodes which, in turn, blocks the inhibitory input over time. This finding implies that the necessary and

  20. Code Compression for DSP

    DTIC Science & Technology

    1998-12-01

    PAGES 6 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8...Automation Conference, June 1998. [Liao95] S. Liao, S. Devadas , K. Keutzer, “Code Density Optimization for Embedded DSP Processors Using Data Compression

  1. Assessing the Impact of Haptic Peripheral Displays for UAV Operators

    DTIC Science & Technology

    2008-03-01

    Institute of Technology,Department of Aeronautics and Astronautics,Cambridge,MA,02139 8 . PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING...PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8 -98) Prescribed by ANSI Std Z39-18 ii... 8 Experimental Design

  2. 40 CFR 81.318 - Kentucky.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Lee County X Leslie County X Letcher County X Lewis County X Lincoln County X Livingston County X... Lawrence County X Lee County X Leslie County X Letcher County X Lewis County X Lincoln County X Livingston... County Unclassifiable/Attainment Lawrence County Unclassifiable/Attainment Lee County Unclassifiable...

  3. 40 CFR 81.318 - Kentucky.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Lee County X Leslie County X Letcher County X Lewis County X Lincoln County X Livingston County X... Lawrence County X Lee County X Leslie County X Letcher County X Lewis County X Lincoln County X Livingston... County Unclassifiable/Attainment Lawrence County Unclassifiable/Attainment Lee County Unclassifiable...

  4. Update on the medical treatment of juvenile idiopathic arthritis.

    PubMed

    Hashkes, Philip J; Laxer, Ronald M

    2006-12-01

    Many exciting developments in the treatment of juvenile idiopathic arthritis (JIA) have emerged recently, including new tools to assess the results of clinical trials (eg, the definition of remission and a radiologic scoring tool). New controlled studies examined the equivalence of meloxicam to naproxen, the efficacy of leflunomide but the superiority of methotrexate, and the use of infliximab in polyarthritis JIA. Initial studies have shown the potential of anti-interleukin (IL)-1 and anti-IL-6 receptor antibody therapy for systemic JIA. Corticosteroid-sparing medications including the use of "biologic modifiers" for JIA-associated uveitis have been described. Evidence-based guidelines for the main subtypes of JIA have been published. However, good evidence on the treatment of several disease subtypes is still lacking. Studies of new medications and the use of combination therapy, including aggressive induction therapy early in the disease course, are necessary to continue improving the outcome of JIA patients.

  5. A case of vemurafenib-induced polyarhritis in a patient with melanoma: how to manage it?

    PubMed

    Babacan, Taner; Türkbeyler, Ibrahim Halil; Balakan, Ozan; Pehlivan, Yavuz; Suner, Ali; Kısacık, Bunyamin

    2017-03-01

    Vemurafenib is an inhibitor of the BRAF V600E mutation which is associated with tumor responses in patients with metastatic melanoma. Although it is generally well tolerated, common side effects of vemurafenib have been reported. Arthralgia is one of the more common adverse event associated with vemurafenib. We herein report a 49-year-old woman diagnosed with metastatic melanoma harboring the BRAF V600E mutation with severe polyarthritis associated with vemurafenib after 7 days of treatment. Sonographic examination of affected joints revealed synovitis and the patient's articular symptoms were improved by analgesic and anti-inflammatory treatment, including corticosteroids. During therapy with selective BRAF inhibitors, arthritis represents a new adverse event that can require dose reduction. In case of this adverse event, treatment with anti-inflammatory drugs, such as ibuprofen and prednisone, should be initiated early to keep patients on treatment and to avoid drug discontinuation and tumor progression. © 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

  6. [Primary chronic polyarthritis with kidney involvement (mesangiocapillary glomerulonephritis)].

    PubMed

    Bürkle, P A

    1979-01-01

    A 34 year old white male patient suffering from seropositive "probable" rheumatoid arthritis developed a severe hypocomplementemic mesangiocapillary glomerulo-nephritis. Rheumatoid factors (Latex test, Waaler-Rose titer) and IgM were markedly elevated in the serum. The third component of complement (C3) was markedly depressed, while the fourth component (C4) was within normal range. The rapid progression of the disease forced us to start an immunosuppressive drug therapy using azathioprine and steroids. Despite marked clinical improvement, e.g. normalisation of complement components, renal function, the disappearance of rheumatoid factor and proteinuria, the second biopsy taken two years later showed unchanged histological and immuno-histological changes of the glomerula.

  7. Biocidal Energetic Materials for the Destruction of Spore Forming Bacteria

    DTIC Science & Technology

    2015-07-01

    Bacteria Spore Gas Antibacterial Thermal Unclassified Unclassified Unclassified SAR 47 Suhithi Peiris...naturally antibacterial and biocidal properties using combustion synthesis of mildly energetic reactants; and, (2) engineering an aerosolized spray...of biocidal gases using unique a deflagration synthesis approach. Accomplishments for all years: Major Activity 1: Creating highly porous

  8. 77 FR 64442 - Airworthiness Directives; PILATUS AIRCRAFT LTD. Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... Maintenance Manual Temporary Revision No. 04-03, dated October 12, 2012, which transmits Unclassified 12-A/AMP..., dated October 15, 2012, which transmits Unclassified 12-B/AMP-04 Structural and Component Limitations... Revision No. 04-03, dated October 15, 2012, which transmits Unclassified 12-A/AMP-04 Structural, Component...

  9. 40 CFR 81.314 - Illinois.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...: Carroll County X Henry County X Mercer County X Rock Island County X Whiteside County X AQCR 70: Madison... X AQCR 72: Massac County X Alexander County X Johnson County X Pope County X Pulaski County X Union... Unclassifiable/Attainment Johnson County Unclassifiable/Attainment Kane County Unclassifiable/Attainment Kankakee...

  10. Assessing the Performance of Military Treatment Facilities

    DTIC Science & Technology

    2011-01-01

    NUMBER OF PAGES 140 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form...Benchmark Analysis of MTF Outcomes . . . . . . . . 73 C . Outpatient utilization and MTF Size...and FY 2006, Mean by MTF Size Quintile . . . . . . . . . . . . . . . . . . . . . 99 C .1. Regression of Outpatient Utilization

  11. Distribution of maternal age and birth order groups in cases with unclassified multiple congenital abnormalities according to the number of component abnormalities: a national population-based case-control study.

    PubMed

    Csermely, Gyula; Czeizel, Andrew E; Veszprémi, Béla

    2015-02-01

    Multiple congenital abnormalities are caused by chromosomal aberrations, mutant major genes and teratogens. A minor proportion of these patients are identified as syndromes but the major part belonging to the group of unclassified multiple CAs (UMCAs). The main objective of this study was to evaluate the maternal age and birth order in pregnant women who had offspring affected with UMCA. The strong association between numerical chromosomal aberrations, e.g., Down syndrome and advanced maternal age is well-known and tested here. The Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980 to 1996, yielded a large population-based national data set with 22,843 malformed newborns or fetuses ("informative cases") included 1349 UMCA cases with their 2407 matched controls. Case-control comparison of maternal age and birth order was made for cases with UMCA, stratified by component numbers and their controls. In addition, 834 cases with Down syndrome were compared to 1432 matched controls. The well-known advanced maternal age with the higher risk for Down syndrome was confirmed. The findings of the study suggest that the young age of mothers associates with the higher risk of UMCA, in addition birth order 4 or more associates with the higher risk for UMCA with 2 and 3 component CAs. This study was the first to analyze the possible maternal and birth order effect for cases with UMCA, and the young age and higher birth order associated with a higher risk for UMCA. © 2014 Wiley Periodicals, Inc.

  12. An Assessment of Contractor Personnel Security Clearance Processes in the Four Defense Intelligence Agencies

    DTIC Science & Technology

    2014-04-14

    Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be...NUMBER OF PAGES 62 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form...Methodology ........................................................................................................................... 1 Finding A. Lack of

  13. Simulation of Dual Firing of Hydrogen and JP-8 in a Swirling Combustor

    DTIC Science & Technology

    2012-06-14

    completed using the Ansys CFX computational fluid dynamics software. The total Lower Heating Value of the fuel mixture is maintained at a constant 6 kW...PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18

  14. Cold Climate Heat Pump

    DTIC Science & Technology

    2013-08-01

    SAR) 18. NUMBER OF PAGES 50 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified...26 7.0 COST ASSESSMENT ...................................................................................................... 29 7.1 COST MODEL ...12. Data set 7 – energy consumption of heat pump and furnace ................................ 22 Figure 13. Experimentally adjusted TRNSYS model

  15. 40 CFR 81.313 - Idaho.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Unclassifiable Lewiston 11/15/90 Unclassifiable Remainder of AQCR 62 (Idaho portion) 11/15/90 Unclassifiable... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Idaho. 81.313 Section 81.313... AREAS FOR AIR QUALITY PLANNING PURPOSES Section 107 Attainment Status Designations § 81.313 Idaho. Idaho...

  16. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 806 (U.S. Geological Survey, TMGS Magnetometer/Towed Array)

    DTIC Science & Technology

    2007-05-01

    BOX 25046, FEDERAL CENTER, M.S. 964 DENVER, CO 80225-0046 TECHNOLOGY TYPE/PLATFORM: TMGS MAGNETOMETER/TOWED ARRAY PREPARED BY: U.S. ARMY...GEOLOGICAL SURVEY, TMGS MAGNETOMETER/TOWED ARRAY) 8-CO-160-UXO-021 Karwatka, Michael... TMGS Magnetometer/Towed Array, MEC Unclassified Unclassified Unclassified SAR (Page ii Blank) i ACKNOWLEDGMENTS

  17. COIN in the Real World

    DTIC Science & Technology

    2009-01-01

    REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 44...Panda, Head of the Water Initiative of Orrissa, interview with author, 24 July 2008. 10. S. R. Ramanujan , “Andhra Pradesh: Peace Talks with PWG?” South

  18. 40 CFR 81.317 - Kansas.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... County X Cherokee County X Cheyenne County X Clark County X Clay County X Cloud County X Coffey County X... Chautauqua County X Cherokee County X Cheyenne County X Clark County X Clay County X Cloud County X Coffey... Unclassifiable/Attainment Clay County Unclassifiable/Attainment Cloud County Unclassifiable/Attainment Coffey...

  19. 40 CFR 81.317 - Kansas.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... County X Cherokee County X Cheyenne County X Clark County X Clay County X Cloud County X Coffey County X... Chautauqua County X Cherokee County X Cheyenne County X Clark County X Clay County X Cloud County X Coffey... Unclassifiable/Attainment Clay County Unclassifiable/Attainment Cloud County Unclassifiable/Attainment Coffey...

  20. Comparative Assessment of Torso and Seat Mounted Restraint Systems using Manikins on the Horizontal Impulse Accelerator

    DTIC Science & Technology

    2017-11-01

    rearward rotation of the head towards the back or shoulder blades ). The y- axis of the head runs from right ear canal to the left ear canal with...PERSON (Monitor) a. REPORT Unclassified b. ABSTRACT Unclassified c . THIS PAGE Unclassified Chris Burneka 19b. TELEPHONE NUMBER...92 APPENDIX C . SAMPLE DATA SHEETS

  1. Report Of Environmental Security Technology Certification Program (ESTCP) UXO Discrimination Study Support Activities: Former Camp Sibert, Etowah and St. Clair Counties, Alabama

    DTIC Science & Technology

    2007-11-01

    PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) PARSONS 4890 University Square Suite 2 Huntsville, Alabama 35816 8 . PERFORMING ORGANIZATION REPORT NUMBER...PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8 -98) Prescribed by ANSI Std Z39-18...Intrusive Investigation Results ...................................................................................... 8 8.2 CLUSTER ANOMALIES

  2. Amorphous and Nanocrystalline High Temperature Magnetic Material for PWR

    DTIC Science & Technology

    2006-03-01

    FOR PUBLICATION. //Signature// //Signature// ______________________________________ __________________________________ JOHN C ...times that of conventional ferrites at room temperature); 2) Frequency: 200 kHz to 1 MHz; 3) Temperature: 200 ° C and above. The goals of the DUST...NAME OF RESPONSIBLE PERSON (Monitor) a. REPORT Unclassified b. ABSTRACT Unclassified c . THIS PAGE Unclassified 17. LIMITATION OF ABSTRACT

  3. The eyes reveal uncertainty about object distinctions in semantic variant primary progressive aphasia.

    PubMed

    Faria, Andreia V; Race, David; Kim, Kevin; Hillis, Argye E

    2018-06-01

    At least three distinct variants of primary progressive aphasia (PPA) have been described, but they are difficult to distinguish early in the course, when individuals experience primarily anomia. People with svPPA are often the hardest to care for, because they have impaired comprehension of words and objects and often have negative changes in comportment. We sought to identify an early marker of semantic variant primary progressive aphasia (svPPA) and to enhance the understanding of the semantic deficit in svPPA. We hypothesized that the pattern of eye tracking in a word picture matching task can differentiate svPPA from other variants and can predict which participants with unclassifiable PPA will progress to svPPA. We tested 19 individuals with PPA on a word picture matching task with eye tracking. We found that individuals with svPPA were less accurate than other variants when the foils were semantic coordinates (horse-cow) or schematically related (horse-saddle), but not when they were thematically related (saw-horse) or unrelated. Moreover, even in the condition in which they were highly accurate (unrelated foils) they looked much more often to the foils and for longer, than other variants or controls. Unclassifiable PPA participants who eventually developed svPPA showed the same pattern. This abnormal pattern was associated with atrophy in bilateral temporal poles. Copyright © 2018. Published by Elsevier Ltd.

  4. Development and Evaluation of a Hyperbaric Toxic Gas Monitor (SubTox) for Disabled Submarines

    DTIC Science & Technology

    2013-08-01

    PAGES 19a. NAME OF RESPONSIBLE PERSON: NEDU Librarian a. REPORT Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified 19b. TELEPHONE...NUMBER (include area code) 850.230.3170 Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. Z39.18 ii ACKNOWLEDGMENTS This work...in September 2012. iii CONTENTS Standard Form 298 ................................................................................ i

  5. Development and Evaluation of a Hyperbaric Toxic Gas Monitor (SUBTOX) for Disabled Submarines

    DTIC Science & Technology

    2013-08-01

    PAGES 19a. NAME OF RESPONSIBLE PERSON: NEDU Librarian a. REPORT Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified 19b. TELEPHONE...NUMBER (include area code) 850.230.3170 Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. Z39.18 ii ACKNOWLEDGMENTS This work...in September 2012. iii CONTENTS Standard Form 298 ................................................................................ i

  6. Arboviruses associated with human disease in Australia.

    PubMed

    Russell, R C; Dwyer, D E

    2000-11-01

    Mosquito-borne arboviruses are an important public health issue in Australia. The alphaviruses Ross River and Barmah Forest virus are widespread and active annually, and cause debilitating polyarthritis. The flaviviruses Murray Valley encephalitis, Kunjin and Japanese encephalitis virus are restricted in distribution and activity but may cause life-threatening illness, and dengue viruses are active in some areas.

  7. Exploration of MEMS G-Switches at 100-10,000 G-Levels with Redundancy

    DTIC Science & Technology

    2014-04-01

    Muntz, A.D. Ketsdever, “Kinetic Modeling of Temperature -Driven Flows in Short Microchannels,” International Journal of Thermal Sciences, Vol. 45, No...switches silicon DRIE Unclassified Unclassified Unclassified UU 59 Suhithi Peiris 703-767-4732 CONVERSION...designed. The devices were fabricated on low resistivity (ɘ.01 Ω-cm) silicon on insulator wafers (SOI) using standard micromachining techniques. Fixed

  8. Advanced Vehicle Power Technology Alliance Technical Workshop and Operations Report

    DTIC Science & Technology

    2011-10-05

    Vehicle Exhaust TEG 2016 1 TEG: Thermo-Electric Generator UNCLASSIFIED: Distribution Statement A. Approved for public release. E16...Equipment 2016 Validation Data: − Power Electronics ― 2020 ― ― UNCLASSIFIED: Distribution Statement A. Approved for public release...Materiel Command (AMC) UNCLASSIFIED: Distribution Statement A. Approved for Public Release Report Documentation Page Form ApprovedOMB No. 0704-0188

  9. 2011 Special Operations Forces Industry Conference

    DTIC Science & Technology

    2011-05-19

    to USSOCOM acquisition objectives and challenges . The Forum is designed to be an informative discussion, with audience participation, between... Challenge UNCLASSIFIED UNCLAS IF ED UNCLASSIFIED UNCLASSIFIED Acquisition Enterprise DOD and Service Labs, International Partners, Industry IR&D SOF...Experimentation • Mission – Support Concept & Solution Development for SOF Capability Gaps, Technology Thrust Areas & Warfighter Challenges • Objectives

  10. National Office of Global Maritime Situational Awareness - Overview

    DTIC Science & Technology

    2008-05-01

    Environment UNCLASSIFIED 21 DATA UNDERSTANDING INFORMATION WISDOM KNOWLEDGE The Information Continuum UNCLASSIFIED • The hub lead will act as the...Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware ...Situational Awareness (OGMSA) UNCLASSIFIED Vision, Mission, Goals, & Objectives Vision A World-Wide Maritime Information Exchange to facilitate user-defined

  11. Effects of Acoustic Impulses on the Middle Ear

    DTIC Science & Technology

    2015-10-01

    and civilian law enforcement weapon systems, civilian recreational hunting and shooting, and industrial high-level impulsive noises (impacts and...PERSON USAMRMC a. REPORT Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified 19b. TELEPHONE NUMBER (include area code) Standard Form...impulsive noises (impacts and impulses). Keywords: Noise exposure; hearing loss, noise -induced; impulsive noise ; reflex; conditioned response

  12. Center for Ground Vehicle Development and Integration

    DTIC Science & Technology

    2011-04-22

    UNCLASSIFIED OPSEC# 21798 CGVDI Organizational Chart CGVDI Director Project and Operations Management Project Management Operations Management Engineered...Metals Welding Assembly / Paint UNCLASSIFIED UNCLASSIFIED OPSEC# 21798 Project and Operations Management CGVDI serves as a single entry point to RDECOM...for ground vehicle system integration projects, as well as for managing cost, schedule, performance and risk. Project Management Operations

  13. A Modular Framework for 3 Way Electrochromic Switches

    DTIC Science & Technology

    2017-09-01

    Department of the Army position unless so designated by other authorized documents. Citation of manufacturer’s or trade names does not constitute an...spectroscopy, molecular design 44 B Christopher Rinderspacher 410-306-2811Unclassified Unclassified Unclassified UU ii Approved for public release...Deprotonated spectral data compared for lowest energy conformer. Superscripts N and D denote the neutral and deprotonated values, respectively

  14. The Factors of Soldier’s Load

    DTIC Science & Technology

    1994-06-03

    transport , the effects of technology, terrain and weather, and physical conditioning. Load, Soidier’s Load, Rucksack, Physical Conditioning, Combat Load...Fighting Load, Sustainment Load, Approach March Load, Fear, Fatigue, Risk, Training, Transport , Techn-logy UNCLASSIFIED UNCLASSIFIED UNCLASSIFIED I .1 THE...standards, myths of peacetime training, the nature of the soldier, lack of transport , the effects of technology, terrain and weather, and physical

  15. Biobased Carbon Fibers and Thermosetting Resins for Use in DOD Composites Applications: SERDP WP 1758 Final Report

    DTIC Science & Technology

    2017-03-01

    RESPONSIBLE PERSON John J La Scala a. REPORT Unclassified b. ABSTRACT Unclassified c . THIS PAGE Unclassified 19b. TELEPHONE NUMBER (Include area...25 and 45 ° C ...........................................................................................102 Fig. 80 Standard viscosity test run with...anhydride. The reaction was run at 80 ° C for 4 h. The flask was cooled down to room temperature and left to stand to precipitate an undissolved

  16. Global Maritime Partnerships Game

    DTIC Science & Technology

    2010-10-08

    develop concepts of operations, doctrine and TTPs to perform various maritime security mission sets. Close collaboration with the USCG is vital to...issues of common concern in order to develop compatible doctrine . c. Objectives UNCLASSIFIED 37 UNCLASSIFIED i. Examine the interaction between...Senkaku Islands (PRC vs. Japan), Indonesia archipelagic sea lanes passage, Northern Territories Dispute (Japan vs. Russia) UNCLASSIFIED 143

  17. Extraction of Carbon Dioxide and Hydrogen from Seawater by an Electrochemical Acidification Cell. Part 3. Scaled-up Mobile Unit Studies (Calendar Year 2011)

    DTIC Science & Technology

    2012-05-30

    Electrochemical Acidification Cell Part III: Scaled-up Mobile Unit Studies (Calendar Year 2011) May 30, 2012 Approved for public release; distribution is...Hydrogen from Seawater by an Electrochemical Acidification Cell Part III: Scaled-up Mobile Unit Studies (Calendar Year 2011) Heather D. Willauer, Dennis R...Unclassified Unlimited Unclassified Unlimited Unclassified Unlimited 41 Heather D. Willauer (202) 767-2673 Electrochemical acidification cell Carbon

  18. Computational Study of the Structure and Mechanical Properties of the Molecular Crystal RDX

    DTIC Science & Technology

    2011-01-01

    Doctor of Philosophy, 2011 Directed By: Assistant Professor Santiago D. Solares , Department of Mechanical Engineering Molecular crystals...Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour per response...NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed

  19. Air Superiority at Red Flag: Mass, Technology, and Winning the Next War

    DTIC Science & Technology

    2009-10-01

    NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Air University,Air Force Research Institute,Maxwell AFB,AL,36112 8 . PERFORMING...REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8 -98) Prescribed by ANSI Std Z39-18 Air University...27 8 Attrition variation versus threat aircraft . . . . . . . 30 vi Figure Page 9 Threat weapon and

  20. Molecular Dynamics Simulations of Surface Processes: Oxygen Recombination on Silica Surfaces at High Temperature

    DTIC Science & Technology

    2007-07-01

    SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT UU 18 . NUMBER OF PAGES 22 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT...unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39- 18 Molecular Dynamics Simulations of Surface...phase. O + Oad + silica -------> O2(v,j) + silica ( 18 ) The first step is

  1. Legal Services: Military Justice

    DTIC Science & Technology

    1999-08-20

    the element generally known as “ organized crime” including both traditional ( La Cosa Nostra) and nontraditional organizations whether or not the...RESPONSIBLE PERSON internet , (blank) lfenster@dtic.mil a. REPORT Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified 19b. TELEPHONE NUMBER...will promptly notify the appropriate Department of De - fense investigative agency of the initiation of the Department of Defense related

  2. Expert Approaches to Analysis

    DTIC Science & Technology

    1999-03-01

    of epistemic forms and games , which can form the basis for building a tool to support expert analyses. 15. SUBJECT TERMS Expert analysis Epistemic...forms Epistemic games SECURITY CLASSIFICATION OF 16. REPORT Unclassified 17. ABSTRACT Unclassified 18. THIS PAGE Unclassified 19. LIMITATION OF...1998 Principal Investigators: Allan Collins & William Ferguson BBN Technologies Introduction 1 Prior Work 2 Structural-Analysis Games 2 Functional

  3. Intelligent Interoperable Agent Toolkit (I2AT)

    DTIC Science & Technology

    2005-02-01

    Agents, Agent Infrastructure, Intelligent Agents 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT UNCLASSIFIED 18. SECURITY ...CLASSIFICATION OF THIS PAGE UNCLASSIFIED 19. SECURITY CLASSIFICATION OF ABSTRACT UNCLASSIFIED 20. LIMITATION OF ABSTRACT UL NSN 7540-01...those that occur while the submarine is submerged. Using CoABS Grid/Jini service discovery events backed up with a small amount of internal bookkeeping

  4. NATOs Deterrence Strategy is Failing. The Enhanced Forward Presence: Delusion or Renewal

    DTIC Science & Technology

    2018-04-20

    can credibly deter Russia. NATO, Enhanced Forward Presence, Deterrence, Multi -Domain Battle, Russia, Baltics Unclassified Unclassified Unclassified...Strategy. The contents of this paper reflect my own personal views and are not necessarily endorsed by the Joint Forces Staff College or the Department... multi -domain capabilities . . . [and] control information,”5 but in response, NATO has struggled to convincingly adjust to this changing character

  5. Author-Editor Guide to Technical Publications Preparation. Revision

    DTIC Science & Technology

    1990-01-01

    meteorology, climatology, military technical publications. ( ") <- 15: Number of Pages: 68 17. Security Classification of Report: Unclassified 1... Security Classification of this Page: Unclassified 19. Security Classification of Abstract: Unclassified 20. Limitation of Abstract: UL Standard Form 298...34 There are, however, February 1983. numerous exceptions. Although some technical material may not be classified in accordance with security AFR 83-2, Air

  6. Early College, Early Success: Early College High School Initiative Impact Study

    ERIC Educational Resources Information Center

    Berger, Andrea; Turk-Bicakci, Lori; Garet, Michael; Song, Mengli; Knudson, Joel; Haxton, Clarisse; Zeiser, Kristina; Hoshen, Gur; Ford, Jennifer; Stephan, Jennifer; Keating, Kaeli; Cassidy, Lauren

    2013-01-01

    In 2002, the Bill & Melinda Gates Foundation launched the Early College High School Initiative (ECHSI) with the primary goal of increasing the opportunity for underserved students to earn a postsecondary credential. To achieve this goal, Early Colleges provide underserved students with exposure to, and support in, college while they are in…

  7. Serial electrophysiological findings in Guillain-Barré syndrome not fulfilling AIDP or AMAN criteria.

    PubMed

    Hosokawa, Takafumi; Nakajima, Hideto; Unoda, Kiichi; Yamane, Kazushi; Doi, Yoshimitsu; Ishida, Shimon; Kimura, Fumiharu; Hanafusa, Toshiaki

    2016-09-01

    Guillain-Barré syndrome (GBS) is categorized into two major subtypes: acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). However, a proportion of patients are electrophysiologically unclassified because of electrophysiological findings that do not fulfil AIDP or AMAN criteria, and underlying pathophysiological mechanisms and lesion distributions of unclassified patients are not well defined. The aims of this study are to elucidate disease pathophysiology and lesion distribution in unclassified patients. We retrospectively studied 48 consecutive GBS patients. Patients were classified on the basis of initial electrophysiological findings according to Ho's criteria. Clinical and serial electrophysiological examinations of unclassified patients were conducted. Twelve (25 %) GBS patients were unclassified. All unclassified patients were able to walk independently at 21 days after onset. No unclassified patients, except one patient with diabetes mellitus, had sensory nerve involvement. Eight patients underwent a follow-up study within 15 days of the initial study. Distal motor latencies (DMLs) of the left median motor nerve were found to be significantly and uniformly decreased compared with initial studies (p = 0.008). DMLs (p < 0.0001) and distal compound action potential (CMAP) durations (p = 0.002) of all nerves were significantly decreased, and distal CMAP amplitudes (p = 0.026) significantly increased compared with initial studies. In unclassified GBS patients, DML values during initial electrophysiological studies would be prolonged compared with expected values in the same patient unaffected by GBS and later improve rapidly with increased distal CMAP amplitudes without the development of excessive temporal dispersions. Lesions are also present in distal nerve segments caused by reversible conduction failure.

  8. Early Diagnosis and Early Intervention in Cerebral Palsy

    PubMed Central

    Hadders-Algra, Mijna

    2014-01-01

    This paper reviews the opportunities and challenges for early diagnosis and early intervention in cerebral palsy (CP). CP describes a group of disorders of the development of movement and posture, causing activity limitation that is attributed to disturbances that occurred in the fetal or infant brain. Therefore, the paper starts with a summary of relevant information from developmental neuroscience. Most lesions underlying CP occur in the second half of gestation, when developmental activity in the brain reaches its summit. Variations in timing of the damage not only result in different lesions but also in different neuroplastic reactions and different associated neuropathologies. This turns CP into a heterogeneous entity. This may mean that the best early diagnostics and the best intervention methods may differ for various subgroups of children with CP. Next, the paper addresses possibilities for early diagnosis. It discusses the predictive value of neuromotor and neurological exams, neuroimaging techniques, and neurophysiological assessments. Prediction is best when complementary techniques are used in longitudinal series. Possibilities for early prediction of CP differ for infants admitted to neonatal intensive care and other infants. In the former group, best prediction is achieved with the combination of neuroimaging and the assessment of general movements, in the latter group, best prediction is based on carefully documented milestones and neurological assessment. The last part reviews early intervention in infants developing CP. Most knowledge on early intervention is based on studies in high-risk infants without CP. In these infants, early intervention programs promote cognitive development until preschool age; motor development profits less. The few studies on early intervention in infants developing CP suggest that programs that stimulate all aspects of infant development by means of family coaching are most promising. More research is urgently needed

  9. Shape Memory Alloy Isolation Valves: Public Quad Chart

    DTIC Science & Technology

    2017-05-12

    NUMBER (Include area code) 12 May 2017 Briefing Charts 12 April 2017 - 12 May 2017 Shape Memory Alloy Isolation Valves: Public Quad Chart William...Unclassified Unclassified Unclassified SAR 2 William Hargus N/A PAYOFF/TRANSITIONTECHNICAL APPROACH MOTIVATION APPLYING AFRL TO SUSTAINMENT • Evaluate...spacecraft (15+ yrs) • Shaped memory alloy isolation valves provide an intrinsically safe isolation system that increases lifetime >5x over SOTA and

  10. The Shipbuilding Technology Transfer Program, Program Summary Report

    DTIC Science & Technology

    1981-08-31

    Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be...NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed...Information for this study was derived from source documentation sup- plied by IHI, information obtained directly from IHI consulting person - nel

  11. Report of the Defense Science Board Permanent Task Force on Nuclear Weapons Surety: Independent Assessment of the Air Force Nuclear Enterprise

    DTIC Science & Technology

    2011-04-01

    person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1...RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std...Members .............................................................................................................. 48  Appendix C:   Findings  from Prior

  12. Acute Radiation Sickness Amelioration Analysis

    DTIC Science & Technology

    1994-05-01

    Emetic Drugs 16. PRICE CODE Antagonists 17. SECURITY CLASSIFICATION 18. SECURITY CLASSIFICATION 19, SECURITY CLASSIFICATION 20. LIMITATION OF ABSTRACT OF...102 UNCLASSIFIED mcuIw IA IIIcaIIin or Isis PAW CLASSFIED BY: N/A since Unclassified. DECLASSIFY ON: N/A since Unclassified. SECURITY CLASSIFICATION OF...Approximately 2000 documents relevant to the development of the candidate anti-emetic drugs ondansetron (Zofran, Glaxo Pharmaceuticals) and granisetron

  13. Chief of Mission Authority as a Model for National Security Integration (INSS Strategic Perspectives, Number 2, December 2010)

    DTIC Science & Technology

    2010-12-01

    unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Institute for...Strategic Studies Strategic Perspectives, No. 2 Series Editor: Phillip C . Saunders National Defense University Press Washington, D.C. December 2010 by...on this subject by Ambassador Robert Oakley and Michael Casey reviewed this question in some detail, arriving at telling insights. Citing the

  14. Measurements of Form and Frictional Drags over a Rough Topographic Bank

    DTIC Science & Technology

    2014-09-01

    processes, Topographic effects Unclassified Unclassified Unclassified UU 24 Hemantha Wijesekera (228) 688-4845 Reset I PAI!fElNTATION RELEASE...sea surface height associated with the sea surface slope resulting from rota- tional effects . Here barotropic pressure gradients associ- ated with...surface elevation are balanced by the Coriolis force; hTi(x, y, t) is the surface elevation resulting from accelerations/decelerations of flow over the

  15. Using Application-Domain Knowledge in the Runtime Support of Multi-Experiment Computational Studies

    DTIC Science & Technology

    2009-01-01

    PAGES 255 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8...178 6.4 Scenario A scaling and breakdown . . . . . . . . . . . . . . . . . 191 6.5 Scenario B scaling and breakdown...Scenario A, as a function of the amount of change in the performance metric parameter. . . . . . . . . . . 186 6.5 Response time in Scenario B , as a

  16. Biocides for the Battlefield - Interim Report

    DTIC Science & Technology

    2010-09-24

    for public release; distribution is unlimited. James H . Wynne Materials Chemistry Branch Chemistry Division Preston a. Fulmer Chemical Dynamics and...b. ABSTRACT c. THIS PAGE 18. NUMBER OF PAGES 17. LIMITATION OF ABSTRACT Biocides for the Battlefield—Interim Report James H . Wynne and Preston A...distribution is unlimited. Unclassified Unclassified Unclassified SAR 25 James H . Wynne (202) 404-4010 The ability to disinfect surfaces and manufacture self

  17. Study of a Multi-Phase Hybrid Heat Exchanger-Reactor (HEX Reactor): Part 2 - Numerical Prediction of Thermal Performance (Postprint)

    DTIC Science & Technology

    2014-01-01

    PERSON (Monitor) a. REPORT Unclassified b . ABSTRACT Unclassified c. THIS PAGE Unclassified Travis E. Michalak 19b. TELEPHONE NUMBER (Include...distribution unlimited.Nicholas Niedbalski a, b ,⇑, Douglas Johnson c, Soumya S. Patnaik a, Debjyoti Banerjee b aAir Force Research Laboratory, Aerospace...Systems Directorate, Power and Controls Division, Mechanical and Thermal Systems Branch, 1950 5th St., Wright-Patterson AFB, OH 45433, United States b Texas

  18. The Pandemic Influenza Policy Model: A Planning Tool for Military Public Health Officials

    DTIC Science & Technology

    2009-06-01

    Containment . Geneva , WHO , 2006. 7. Luke CJ , Subbarao K : Vaccines for pandemic infl uenza . Emerg Infect Dis 2006 ; 12 (1) : 66 – 72...Report (SAR) 18. NUMBER OF PAGES 9 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified...simulations . Simulation 2005 ; 81 (10) : 671 – 99 . 19. Pourbohloul B , Meyers LA , Skowronski DM , Krajden M , Patrick DM , Brunham RC

  19. Study of Software Tools to Support Systems Engineering Management

    DTIC Science & Technology

    2015-06-01

    Management 15. NUMBER OF PAGES 137 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT Unclassified 18. SECURITY CLASSIFICATION OF THIS...AVAILABILITY STATEMENT Approved for public release; distribution is unlimited 12b. DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) According to a...PAGE Unclassified 19. SECURITY CLASSIFICATION OF ABSTRACT Unclassified 20. LIMITATION OF ABSTRACT UU NSN 7540–01–280–5500 Standard Form 298

  20. Defense Advisory Committee on Women in the Services (DACOWITS) 1951-2014: 63 Years of DACOWITS

    DTIC Science & Technology

    2014-12-01

    Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be...SAR) 18. NUMBER OF PAGES 213 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified...that experts inside and outside the DoD recognize a strong correlation between the occurrence of sexual harassment and sexual assault. Sexual

  1. Assessment of the Activation State of RAS and Map Kinase in Human Breast Cancer Specimens (96Breast)

    DTIC Science & Technology

    1999-09-01

    Cancer 16. PRICE CODE 17. SECURITY CLASSIFICATION 18 . SECURITY CLASSIFICATION 19. SECURITY CLASSIFICATION 20. LIMITATION OF ABSTRACT OF REPORT OF...THIS PAGE OF ABSTRACT Unclassified Unclassified Unclassified Unlimited NSN 7640-01-280-5500 Standard Form 298 (Rev. 2-89) Prescribed by ANSI Std. Z39- 18 ...transformation and regulate cell morphology, adhesion and motility through cytoskeletal dynamics and play an important role in carcinogenesis ( 18 ). Rho

  2. Functional Interactions Between c-Src and HER1 Potentiate Neoplastic Transformation: Implications for the Etiology of Human Breast Cancer

    DTIC Science & Technology

    2000-07-01

    receptor 120 16. PRICE CODE 17. SECURITY CLASSIFICATION 18 . SECURITY CLASSIFICATION 19. SECURITY CLASSIFICATION 20. LIMITATION OF ABSTRACT OF REPORT OF...THIS PAGE OF ABSTRACT Unclassified Unclassified Unclassified Unlimited NSN 7540-01-280-5500 Standard Form 298 (Rev. 2-89) Prescribed by ANSI Std. Z39- 18 ... 18 -26 Appended Manuscripts 3 INTRODUCTION Recent work in our laboratory has established the importance of a

  3. US Army Europe: Sharing the ITAM Tenets with Multinational Partners in Africa

    DTIC Science & Technology

    2011-05-01

    TenetsUNCLASSIFIED  Initiate a conservation partnership to support land management activities on 303rd training lands.  Significance of Brigade 303...World Wildlife Fund ( WWF ) African Wildlife Foundation (AWF) Local surrounding communities Partners Any Mission, Anywhere UNCLASSIFIED As of 5 May... Partnerships which should help sustain TPDF’s valuable training area resources Any Mission, Anywhere UNCLASSIFIED As of 5 May 2011 USAREUR; Sharing

  4. Scalable Power-Component Models for Concept Testing

    DTIC Science & Technology

    2011-08-17

    Scalable Power-Component Models for Concept Testing, Mazzola, et al . UNCLASSIFIED: Dist A. Approved for public release 2011 NDIA GROUND VEHICLE...Power-Component Models for Concept Testing, Mazzola, et al . UNCLASSIFIED: Dist A. Approved for public release Page 2 of 8 technology that has yet...Technology Symposium (GVSETS) Scalable Power-Component Models for Concept Testing, Mazzola, et al . UNCLASSIFIED: Dist A. Approved for public release

  5. Design and Performance of Ka-Band Fiber-Optic Delay Lines

    DTIC Science & Technology

    2012-12-28

    Approved for public release; distribution is unlimited. Vincent J. Urick Joseph M. singley christopher e. sUnderMan John F. diehl keith J...PAGES 17. LIMITATION OF ABSTRACT Design and Performance of Ka-Band Fiber-Optic Delay Lines Vincent J. Urick , Joseph M. Singley, Christopher E...Approved for public release; distribution is unlimited. Unclassified Unlimited Unclassified Unlimited Unclassified Unlimited 64 Vincent J. Urick (202

  6. Background Error Correlation Modeling with Diffusion Operators

    DTIC Science & Technology

    2013-01-01

    RESPONSIBLE PERSON 19b. TELEPHONE NUMBER (Include area code) 07-10-2013 Book Chapter Background Error Correlation Modeling with Diffusion Operators...normalization Unclassified Unclassified Unclassified UU 27 Max Yaremchuk (228) 688-5259 Reset Chapter 8 Background error correlation modeling with diffusion ...field, then a structure like this simulates enhanced diffusive transport of model errors in the regions of strong cur- rents on the background of

  7. Littoral Combat Ship (LCS)

    DTIC Science & Technology

    2015-12-01

    Selected Acquisition Report ( SAR ) RCS: DD-A&T(Q&A)823-374 Littoral Combat Ship (LCS) As of FY 2017 President’s Budget Defense Acquisition...Management Information Retrieval (DAMIR) UNCLASSIFIED LCS December 2015 SAR UNCLASSIFIED 2 Table of Contents Common Acronyms and Abbreviations for...and Support PAUC - Program Acquisition Unit Cost LCS December 2015 SAR UNCLASSIFIED 3 PB - President’s Budget PE - Program Element PEO - Program

  8. Deliberate and Crisis Action Planning and Execution Segments Increment 2B (DCAPES Inc 2B)

    DTIC Science & Technology

    2016-03-01

    2016 Major Automated Information System Annual Report Deliberate and Crisis Action Planning and Execution Segments Increment 2B (DCAPES Inc 2B...Defense Acquisition Management Information Retrieval (DAMIR) UNCLASSIFIED DCAPES Inc 2B 2016 MAR UNCLASSIFIED 2 Table of Contents Common...Logistics DCAPES Inc 2B 2016 MAR UNCLASSIFIED 3 Lt Col Christopher Thrower 201 East Moore Drive Building 856, Room 154 Maxwell Air Force Base-Gunter

  9. Limiting Regret: Building the Army We Will Need

    DTIC Science & Technology

    2015-08-01

    burden for the collection of information is estimated to average 1 hour per response , including the time for reviewing instructions, searching existing...NUMBER OF PAGES 23 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298...Army’s ability to help execute the national defense strategy against key threats. The documentation for this analysis was funded by philanthropic

  10. Air and Space Power Journal. Volume 24, Number 1, Spring 2010

    DTIC Science & Technology

    2010-01-01

    unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 SP IN E http...messen- gers to conduct psychological operations (PSYOP). EW operations seek to achieve ef- fects across the electromagnetic domain, including radio...a man­ made virtual domain. Further study reveals its natural similarities to the other domains, as defined by the electromagnetic spectrum

  11. A Novel Approach for a Hostile Arms Fire Sensor

    DTIC Science & Technology

    2011-08-10

    need to be addressed. Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of information is estimated...4 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98...not limited to atmospheric transmission and solar emission. The EM spectrum has been partitioned into general regions that have common

  12. Logistics Composite Model (LCOM) Workbook

    DTIC Science & Technology

    1976-06-01

    nc;-J to e UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE (When Dots Ew.ervol. REPORT DOCUMENTATION PAGE READ INSTRUCTIONS BEFORE COMPLETING FORM I...Controlling Office) 15. SECURITY CLASS. (of this report) Unclassified 158. DECLASSIFICATIONDOWNGRADING SCHEDULE 16. DISTRIBUTION STATEMENT (of this Report...ID SECURITY CLASSIFICATION OF THIS PAGE (When Des Entered) K7 UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE(Whon Dal Entore o l Logic networks

  13. Development and Ballistic Testing of a New Class of Auto-Tempered High-Hard Steels Under Military Specification MIL-DTL-46100E

    DTIC Science & Technology

    2009-09-01

    Showalter a . REPORT Unclassified b. ABSTRACT Unclassified c . THIS PAGE Unclassified 19b. TELEPHONE NUMBER (Include area code) (410) 278-7308...OF COPIES ORGANIZATION COPIES ORGANIZATION 21 3 CDR US ARMY TACOM AMSTA TR S T FURMANIAK L FRANKS D TEMPLETON MS 263 WARREN MI...R BANTON R GUPTA R CARTER L KECSKES S MATHAUDHU D SNOHA RDRL WMM R DOWDING J BEATTY RDRL WMM C R

  14. Sparsity-Based Representation for Classification Algorithms and Comparison Results for Transient Acoustic Signals

    DTIC Science & Technology

    2016-05-01

    large but correlated noise and signal interference (i.e., low -rank interference). Another contribution is the implementation of deep learning...representation, low rank, deep learning 52 Tung-Duong Tran-Luu 301-394-3082Unclassified Unclassified Unclassified UU ii Approved for public release; distribution...Classification of Acoustic Transients 6 3.2 Joint Sparse Representation with Low -Rank Interference 7 3.3 Simultaneous Group-and-Joint Sparse Representation

  15. Rigid Polyurethane Foam (RPF) Technology for Countermine (SEA) Program - Phase 1

    DTIC Science & Technology

    1997-01-01

    Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour...05 MAY 1997 2. REPORT TYPE 3. DATES COVERED 00-00-1997 to 00-00-1997 4. TITLE AND SUBTITLE Rigid Polyurethane Foam (RPF) Technology for...unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18

  16. Proceedings of the Antenna Applications Symposium (32nd) Held in Monticello, Illinois on 16-18 September 2008. Volume 1

    DTIC Science & Technology

    2008-12-20

    Equation 6 for the sample likelihood function gives a “concentrated likelihood function,” which depends on correlation parameters θh and ph. This...step one and estimates correlation parameters using the new data set including all previous sample points and the new data point x. The algorithm...Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified UU 279 19b. TELEPHONE NUMBER (include area code ) N/A

  17. Organic Techniques for Protecting Virtual Private Network (VPN) Services from Access Link Flooding Attacks

    DTIC Science & Technology

    2002-01-01

    Submitted to ICN 2002 Organic Techniques for Protecting Virtual Private Network (VPN) Services from Access Link Flooding Attacks1 Ranga S. Ramanujan ...using these techniques is also described. Contact author: Dr. Ranga S. Ramanujan Architecture Technology Corporation 9971 Valley View Road Eden Prairie...OF ABSTRACT 18. NUMBER OF PAGES 15 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified

  18. Integration of Computational Geometry, Finite Element, and Multibody System Algorithms for the Development of New Computational Methodology for High-Fidelity Vehicle Systems Modeling and Simulation

    DTIC Science & Technology

    2013-04-11

    vehicle dynamics. Unclassified Unclassified Unclassified UU 9 Dr. Paramsothy Jayakumar (586) 282-4896 Computational Dynamics Inc.   0    Name of...Technical Representative Dr. Paramsothy Jayakumar TARDEC Computational Dynamics Inc.   1    Project Summary This project aims at addressing and...applications. This literature review is being summarized and incorporated into the paper. The commentary provided by Dr. Jayakumar was addressed and

  19. Combustible Cartridge Cases: Current Status and Future Prospects

    DTIC Science & Technology

    1992-08-01

    and presents new models of combustible cartridge case burning . Following a summary of experimental data, it concludes with proposals for further...UNCLASSIFIED UNCLASSIFIED UNCLASSIFIED SAR NSN 7540-01-280-5500 Standard Form 298 (Rev 2-89) Precribed by ANSI Std Z39-19 IWFENTIONALLY LEFT BLANK...7 3.3 In-Depth Burning Model ........................................ 7 3.3.1 M odel A ................................................ 9 3.3.2

  20. Report on Scientific Basis for Paint Stripping: Mechanism of Methylene Chloride Based Paint Removers

    DTIC Science & Technology

    2011-10-20

    Chloride Based Paint Removers October 20, 2011 Approved for public release; distribution is unlimited. James H. Wynne Materials Chemistry Branch...Z39.18 Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing...5320 NRL/MR/6120--11-9368 SERDP WP-1682 Approved for public release; distribution is unlimited. Unclassified Unclassified Unclassified UU 72 James H

  1. Constrained Fisher Scoring for a Mixture of Factor Analyzers

    DTIC Science & Technology

    2016-09-01

    expectation -maximization algorithm with similar computational requirements. Lastly, we demonstrate the efficacy of the proposed method for learning a... expectation maximization 44 Gene T Whipps 301 394 2372Unclassified Unclassified Unclassified UU ii Approved for public release; distribution is unlimited...14 3.6 Relationship with Expectation -Maximization 16 4. Simulation Examples 16 4.1 Synthetic MFA Example 17 4.2 Manifold Learning Example 22 5

  2. Development of Regulatory Processes in the Symbiosis Between the Sea Anemone Aiptasia pallida and its Dinoflagellate Symbionts

    DTIC Science & Technology

    1994-09-01

    affected both dinoflagellates ( zooxanthellae ) and their hosts. Studies included the infection of algae-free hosts, responses to "host factors...34, metabolism of 15 N-ammonium and other aspects of how nitrogen was utilized by the symbiotic systems. Zooxanthellae of A. pallida showed distinct reposes to...S’ Symbiosis, zooxanthellae , dinoflagellates, sea anemones, IC i corals Unclassified Unclassified jUnclassified UL TABLE OF CONTENTS Page # Summary

  3. Quantum Algorithms for Fermionic Quantum Field Theories

    DTIC Science & Technology

    2014-04-28

    preskill@theory.caltech.edu 1 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of information is...NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98...operators of momentum modes. (The choice between these forms of measurement depends on the application.) 2.3 Complexity In this section we bound the

  4. Early Childhood Systems: Transforming Early Learning

    ERIC Educational Resources Information Center

    Kagan, Sharon Lynn, Ed.; Kauertz, Kristie, Ed.

    2012-01-01

    In this seminal volume, leading authorities strategize about how to create early childhood systems that transcend politics and economics to serve the needs of all young children. The authors offer different interpretations of the nature of early childhood systems, discuss the elements necessary to support their development, and examine how…

  5. Bibliography of Unclassified Reports: FY 1983.

    DTIC Science & Technology

    1983-11-01

    selected automobile and motorcyclemagazines with a high proportion of readership in this age group. The strategy was evaluated by comparing the number of...climate of the human resource management ( HRM ) survey in compliance with the FY82 Navy Affirmative Action Plan. The most recent 1-year data base (I July...1980 to 30 June 1981) of HRM survey responses was used, yielding a sample of 35,690 personnel. The responses of whites and blacks, whites and

  6. Early Course of Inflammatory Bowel Disease in a Population-Based Inception Cohort Study From 8 Countries in Asia and Australia.

    PubMed

    Ng, Siew C; Zeng, Zhirong; Niewiadomski, Ola; Tang, Whitney; Bell, Sally; Kamm, Michael A; Hu, Pinjin; de Silva, H Janaka; Niriella, Madunil A; Udara, W S A A Yasith; Ong, David; Ling, Khoon Lin; Ooi, Choon Jin; Hilmi, Ida; Lee Goh, Khean; Ouyang, Qin; Wang, Yu Fang; Wu, Kaichun; Wang, Xin; Pisespongsa, Pises; Manatsathit, Sathaporn; Aniwan, Satimai; Limsrivilai, Julajak; Gunawan, Jeffri; Simadibrata, Marcellus; Abdullah, Murdani; Tsang, Steve W C; Lo, Fu Hang; Hui, Aric J; Chow, Chung Mo; Yu, Hon Ho; Li, Mo Fong; Ng, Ka Kei; Ching, Jessica Y L; Chan, Victor; Wu, Justin C Y; Chan, Francis K L; Chen, Minhu; Sung, Joseph J Y

    2016-01-01

    The incidence of inflammatory bowel disease (IBD) is increasing in Asia, but little is known about disease progression in this region. The Asia-Pacific Crohn's and Colitis Epidemiology Study was initiated in 2011, enrolling subjects from 8 countries in Asia (China, Hong Kong, Indonesia, Sri Lanka, Macau, Malaysia, Singapore, and Thailand) and Australia. We present data from this ongoing study. We collected data on 413 patients diagnosed with IBD (222 with ulcerative colitis [UC], 181 with Crohn's disease [CD], 10 with IBD unclassified; median age, 37 y) from 2011 through 2013. We analyzed the disease course and severity and mortality. Risks for medical and surgical therapies were assessed using Kaplan-Meier analysis. The cumulative probability that CD would change from inflammatory to stricturing or penetrating disease was 19.6%. The cumulative probabilities for use of immunosuppressants or anti-tumor necrosis factor agents were 58.9% and 12.0% for patients with CD, and 12.7% and 0.9% for patients with UC, respectively. Perianal CD was associated with an increased risk of anti-tumor necrosis factor therapy within 1 year of its diagnosis (hazard ratio, 2.97; 95% confidence interval, 1.09-8.09). The cumulative probabilities for surgery 1 year after diagnosis were 9.1% for patients with CD and 0.9% for patients with UC. Patients with CD and penetrating disease had a 7-fold increase for risk of surgery, compared with patients with inflammatory disease (hazard ratio, 7.67; 95% confidence interval, 3.93-14.96). The overall mortality for patients with IBD was 0.7%. In a prospective population-based study, we found that the early course of disease in patients with IBD in Asia was comparable with that of the West. Patients with CD frequently progress to complicated disease and have accelerated use of immunosuppressants. Few patients with early stage UC undergo surgery in Asia. Increasing our understanding of IBD progression in different populations can help optimize therapy

  7. Early Intervention.

    ERIC Educational Resources Information Center

    Nathanson, Jeanne H., Ed.

    1992-01-01

    This theme issue focuses on early intervention. The four articles presented on this theme are: (1) "Deaf Infants, Hearing Mothers: A Research Report" (Kathryn P. Meadow-Orlans, and others), reporting findings on effects of auditory loss on early development; (2) "Maintaining Involvement of Inner City Families in Early Intervention Programs through…

  8. SERC 2014-2018 Technical Plan

    DTIC Science & Technology

    2013-10-25

    assurance-case analysis that are not only more powerful in anomaly detection , but also leading to stronger possibilities for positive assurance and to...PAGES 50 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8...base for responding to cyber-attacks; and ( c ) combine techniques developed for automatic control systems in a manner that will both enable defense

  9. Touch-Based Interaction Approach for Network Science Research and Visualization

    DTIC Science & Technology

    2016-01-01

    NOTICES Disclaimers The findings in this report are not to be construed as an official Department of the Army position unless so designated...other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a...NAME OF RESPONSIBLE PERSON Andrew Toth a. REPORT Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified 19b. TELEPHONE NUMBER

  10. Environmental Assessment: Replacement of Subscale Drone Recovery Boat Dock at Tyndall Air Force Base, Florida

    DTIC Science & Technology

    2009-12-01

    Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person ...90 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98...Prescribed by ANSI Std Z39-18 Final Finding of No Significant Impact for Construction and Operation of an Alternate Drone Launch System at Tyndall

  11. Agent Based Simulation Design for Aggregation and Disaggregation

    DTIC Science & Technology

    2011-12-01

    of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB... PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18...theo- retical analysis) finding conditions under which aggregation equations might be reasonably valid (requires theo- retical analysis

  12. Supplemental Environmental Assessment for the Mid-Bay Bridge Connector Phases 2 and 3, Eglin Air Force Base, Florida

    DTIC Science & Technology

    2010-08-03

    Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a... PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18...Value FONPA Finding of No Practicable Alternative FONSI Finding of No Significant Impact FS Florida Statutes FWC Florida Fish and Wildlife

  13. Node Ranking Tool - NoRT

    DTIC Science & Technology

    2018-03-23

    Unclassified Unlimited Unclassified Unlimited Unclassified Unlimited 23 Ira S. Moskowitz (202) 404-7930 This paper gives a description of the Node Ranking Tool...Disease, Virus, Expectation, Pandemic, Close- ness, Graph, Degree, Spectrum. I. INTRODUCTION THis paper gives a description of the Node Ranking Tool...is very much dependent upon which centrality measure we use. Therefore, following [6] and [3], we use TOPSIS to evaluate our decisions about the

  14. Investigation of Novel Glass Scintillators for Gamma Ray Detection

    DTIC Science & Technology

    2013-02-01

    February 2013 HDTRA1-07-1-0017 Mansoor Sheik- Bahae Prepared by: Regents of University of New Mexico Department of...PAGE ABSTRACT OF PAGES Unclassified Unclassified Unclassified uu 17 19a. NAME OF RESPONSIBLE PERSON Mansoor Sheik- Bahae 19b. TaEPHONE NUMBER...t4 I transition Fig. 2: Effect of conduction band edge position on the relaxation dynamics of the Ce3+ excited state. The key here was refining the

  15. Agility - The Danish Way (Briefing Charts)

    DTIC Science & Technology

    2014-06-01

    unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 ‘A’ PLAN… • Theory ...Social Military Economic Infrastructure Assessment Planning Execution Knowledge Base PMESII SAS 050 C2 Model – Sensemaking (INTELLIGENCE) C2...Warfighting COMMANDER Intelligence manages the sensemaking (ex SA/SU) – it is the make or break for battlespace agility. How we ‘observe’ and

  16. Things Don’t Just Go Back to Normal: The Implications of Antenatal and Postpartum Physiology and Morphology for the Resumption of Fitness Testing

    DTIC Science & Technology

    2015-04-08

    September 2014 - April 2015 Things Don’t Just Go Back to Normal: The Implications of Antenatal and Postpartum Physiology and Morphology for the...physiology; morphology Unclassified Unclassified Unclassified UU 56 Marine Corps University/Command a (703) 784-3330 (Admin Office) United States Marine...MASTER OF MILITARY STUDIES Things Don’t Just Go Back to Normal: The Implications of Antenatal and Postpartum Physiology and Morphology for the

  17. Simultaneous Determination of Cyanide and Thiocyanate in Plasma by Chemical Ionization Gas Chromatography Mass-Spectrometry (CI-GC-MS)

    DTIC Science & Technology

    2012-09-04

    3]. Once cyanide is introduced into cells, it inhibits cytochrome c oxidase, which subsequently causes cellular hypoxia, cytotoxic anoxia, and may...NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by...Medical Center (Lackland Air Force Base, TX). Upon re- ceipt, the plasma was frozen and stored at −80 ° C until utilized for optimizing analytical

  18. Molecular-Level Analysis of Shock-Wave Physics and Derivation of the Hugoniot Relations for Fused Silica

    DTIC Science & Technology

    2012-06-01

    product manufacturing are associated with relatively low costs; and ( c ) ballistic and blast impact survivability of ceramic glasses can be substantially...19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98...b) continuum-material approximations (Ref 5–7, 15–18); and ( c ) meso-length scale models based on explicit representation of cracks (Ref 19, 20

  19. Pupillometry and Saccades as Objective mTBI Biomark

    DTIC Science & Technology

    2015-10-01

    1204, Arlington, VA 22202- 4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any...OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE PERSON USAMRMC a. REPORT Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified...assessment tools, overlap of symptoms in co-morbid conditions such as post-traumatic stress disorder (PTSD), and the interpretation of signs and symptoms

  20. Prognostic Fusion for Uncertainty Reduction

    DTIC Science & Technology

    2007-02-01

    Damage estimates are arrived at using sensor information such as oil debris monitoring data as well as vibration data. The method detects the onset of...NAME OF RESPONSIBLE PERSON ( Monitor ) a. REPORT Unclassified b. ABSTRACT Unclassified c . THIS PAGE Unclassified 17. LIMITATION OF ABSTRACT...estimates are arrived at using sensor information such as oil debris monitoring data as well as vibration data. The method detects the onset of

  1. Systemic Policy Compliance in a Multi-Jurisdictional Defence Program - Defence Suppliers Perspective

    DTIC Science & Technology

    2010-11-01

    unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Systemic Policy...navigation systems) and Spad (a French company specialized in simulation). The three organizations collaborate in order to deliver the Navigation System end...read  Packard employees assigned to Program-Z DD can read – Bilateral PIEA2 between Curtiss and Spad • Purpose = protects Curtiss IP exchanged with

  2. Collins Center Update. Volume 16, Issue 4, July-September 2014

    DTIC Science & Technology

    2014-09-01

    OF RESPONSIBLE PERSON a REPORT unclassified b ABSTRACT unclassified c THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by...ANSI Std Z39-18 2 C S L D The USAWC SBP consisted of five weeks of instruction that included core strategic studies instruction, a capstone... Knott and Mr. Kevin Dixon (Strategic Outreach Division) provided battlefield staff rides to Antietam and Gettysburg, exploring insights on the

  3. Predicting Suicide Attacks: Integrating Spatial, Temporal, and Social Features of Terrorist Attack Targets

    DTIC Science & Technology

    2013-01-01

    used in health and criminol- ogy to predict outcomes (Browning, Cagney, and Wen, 2003; Samp- son, Morenoff, and Gannon -Rowley, 2002 ). For each...Bernard, H . Russell , and Gery W. Ryan, Analyzing Qualitative Data: Systematic Approaches, Thousand Oaks, Calif.: Sage, 2010. Berrebi, Claude, “Evidence...PERSON a. REPORT unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18

  4. Machine Visual Motion Detection Modeled on Vertebrate Retina

    DTIC Science & Technology

    1988-01-01

    18. NUMBER OF PAGES 9 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified Standard Form...mechanism of direction selectivity. (a) shows the use of persistent lateral inhibition to block conduction in the null direction. ( b ) shows the use of...Bipolar elements Bipolar ( B ) elements compare the inputs from local receptor and horizontal elements, passing on the positive value of the difference

  5. Determination of Clinical and Demographic Predictors of Laboratory-confirmed Influenza with Subtype Analysis

    DTIC Science & Technology

    2012-06-07

    Advisory Committee on Immunization Practicies (ACIP). vol. 57th edition. Atlanta, GA: MMWR; 2008:1–59. 3. Cox NJ, Subbarao K : Influenza. Lancet 1999...to April 2008. Reverse-transcriptase polymerase chain reaction testing and viral culture for influenza A and B with subtyping were performed on all...REPORT unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 RESEARCH

  6. Chiral Separation of G-type Chemical Warfare Nerve Agents via Analytical Seupercritical Fluid Chromatography

    DTIC Science & Technology

    2014-01-01

    UNCLASSIFIED b . ABSTRACT UNCLASSIFIED c. THIS PAGE UNCLASSIFIED UNLIMITED 8 19b. TELEPHONE NUMBER (include area code) 410-436-4412 Standard Form 298...plates (N), retention fac- tor ( k ), separation factor (α), and resolution (RS). 16 Parameters were used to verify both the enantioselectivity and the...time, tR, was determined by averaging the time to peak max- ima from subsequent injections. Calculation of k was carried out using the following

  7. Deductive Sensemaking Principles Using Personal Constructs of the Field Commanders

    DTIC Science & Technology

    2007-06-01

    unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified ABSTRACT The virtue of defining and measuring the commander’s performance solely...seeing the world in which he lives; ( b ) the individual builds constructs and tries them on evolving contexts; (c) the construct can be applied to...ability to (a) anticipate future state of nature; ( b ) cope with state changing in the battlefield; and (c) replicate past experiences and map them into

  8. Veteran Stereotypes: A Closer Look

    DTIC Science & Technology

    2014-10-01

    A White Paper Veteran Stereotypes : A Closer Look Office of the Chairman of the Joint Chiefs of Staff...2014 to 00-00-2014 4. TITLE AND SUBTITLE Veteran Stereotypes : A Closer Look 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 UNCLASSIFIED There are stereotypes that somehow always

  9. Trust and Decision Making: An Empirical Platform

    DTIC Science & Technology

    2008-06-01

    13th ICCRTS “C2 for Complex Endeavors” Trust and Decision Making : An Empirical Platform Topic(s): Cognitive and Social Issues...and Decision Making : An Empirical Platform 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e...PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Trust and Decision Making : An Empirical Platform Dr. Joseph B

  10. Administration: Gifts for Distribution to Individuals

    DTIC Science & Technology

    1981-05-01

    Army Regulation 1–101 Administration Gifts for Distribution to Individuals Headquarters Department of the Army Washington, DC 1 May 1981 UNCLASSIFIED...Report Documentation Page Report Date 01 May 1981 Report Type N/A Dates Covered (from... to) - Title and Subtitle Administration: Gifts for...unclassified Classification of Abstract unclassified Limitation of Abstract UU Number of Pages 7 SUMMARY of CHANGE AR 1–101 Gifts for Distribution to

  11. Analysis of Photonic Phase-Shifting Technique Employing Amplitude-Controlled Fiber-Optic Delay Lines

    DTIC Science & Technology

    2012-01-13

    Controlled Fiber-Optic Delay Lines January 13, 2012 Approved for public release; distribution is unlimited. Meredith N. draa ViNceNt J. Urick keith J...Draa, Vincent J. Urick , and Keith J. Williams Naval Research Laboratory, Code 5652 4555 Overlook Avenue, SW Washington, DC 20375-5320 NRL/MR/5650--12...9376 Approved for public release; distribution is unlimited. Unclassified Unclassified Unclassified UU 29 Vincent J. Urick (202) 767-9352 Fiber optics

  12. The National Shipbuilding Research Program. 1989 Ship Production Symposium. Paper No. 13: NIDDESC: Meeting the Data Exchange Challenge Through a Cooperative Effort

    DTIC Science & Technology

    1989-09-01

    RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18... Computer Aided Design (CAD) and Manufacturing (CAM) techniques in the marine industry has increased significantly in recent years, With more...somewhat from ship to ship. All of the activities and companies involved have improved this process by utilizing computer tools. For example, many

  13. Trusted Autonomy: Concept Development in Technology Foresight

    DTIC Science & Technology

    2015-09-01

    executing the response . UNCLASSIFIED 19 UNCLASSIFIED DST-Group-TR-3153 UNCLASSIFIED 20 Previous models explored autonomy through the lenses of...w /users to leam to tackle complex problems Robots are able to intanalise and use world models Controllers have multiple modules based on leru.ning...technology across society. It aims to describe usage or uptake, and evolving trends, in technological development over time. Through doing so, it seeks to

  14. An Analysis of Diffuse Light Attenuation in the Northern Gulf of Mexico Hypoxic Zone Using the SeaWiFS Satellite Data Record

    DTIC Science & Technology

    2011-01-01

    ELEMENT NUMBER 0601153N 6. AUTHOR(S) B . Schaeffer, G. Sinclair, J. Lehrter, M. Murrell, J. Kurtz, Richard Gould, D. Yates, G. Smith 5d. PROJECT...continental shelf, hypoxia 16. SECURITY CLASSIFICATION OF: a. REPORT Unclassified b . ABSTRACT Unclassified c. THIS PAGE Unclassified 17. LIMITATION OF...diffuse light at- tenuation were evaluated with a Model II geometric mean linear re- gression (Laws & Archie , 1981) using only in situ data

  15. Identifying Acquisition Patterns of Failure Using Systems Archetypes

    DTIC Science & Technology

    2008-04-02

    OF PAGES 18 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev...any but the smallest programs, complete path coverage for defect detection is impractical. Adapted from Pressman , R.S., Software Engineering: A...Firefighting” concept from “Past the Tipping Point” Fix S O B Problem Symptom R “Fixes That Fail” – Systems Archetype S Unintended Consequences S

  16. Dynamic Camouflage in Benthic and Pelagic Cephalopods: An Interdisciplinary Approach to Crypsis Based on Color, Reflection, and Bioluminescence

    DTIC Science & Technology

    2010-01-01

    cephalopod and model both the shallow and deep-water world from the animals’ points of view. Report Documentation Page Form ApprovedOMB No...REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 2 3. To... solar zenith angles including noon and sunset conditions. Five of these deployments were made with the optical sensors oriented horizontally. Ten

  17. Database Design Methodology and Database Management System for Computer-Aided Structural Design Optimization.

    DTIC Science & Technology

    1984-12-01

    52242 Prepared for the AIR FORCE OFFICE OF SCIENTIFIC RESEARCH Under Grant No. AFOSR 82-0322 December 1984 ~ " ’w Unclassified SECURITY CLASSIFICATION4...OF THIS PAGE REPORT DOCUMENTATION PAGE is REPORT SECURITY CLASSIFICATION lb. RESTRICTIVE MARKINGS Unclassified None 20 SECURITY CLASSIFICATION...designer .and computer- are 20 DIiRIBUTION/AVAILABI LIT Y 0P ABSTR4ACT 21 ABSTRACT SECURITY CLASSIFICA1ONr UNCLASSIFIED/UNLIMITED SAME AS APT OTIC USERS

  18. Awareness-Enabled Coordination

    DTIC Science & Technology

    2006-04-01

    contextualization, policy, team coordination. 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT UNCLASSIFIED 18. SECURITY ...CLASSIFICATION OF THIS PAGE 19. SECURITY CLASSIFICATION 20. LIMITATION OF ABSTRACT OF ABSTRACT UNCLASSIFIED UNCLASSIFIED UL NSN 7540-01-280... netowrk . Federal Austin FBI DHS CBP BobMary Carol John Alice 1 5 Texas NJ 3 4 1 2 3 4 Xavier Yanni 5 6 2 1 2 4 3 Policy & resource flow n Policies

  19. Ballistic Testing of Australian Bisalloy Steel for Armor Applications

    DTIC Science & Technology

    2007-06-01

    CLASSIFICATION OF: 19a. NAME OF RESPONSIBLE PERSON Dwight D. Showalter a . REPORT UNCLASSIFIED b. ABSTRACT UNCLASSIFIED c . THIS PAGE UNCLASSIFIED 17...WASHINGTON PA 15301 A ND 2 SOUTHWEST RSCH INST C ANDERSON J WALKER 6220 CULEB SAN ANTONIO TX 7 DEPT OF APPL MECH & SVC R011 S NEMAT...Ballistic Testing of Australian Bisalloy Steel for Armor Applications by Dwight D. Showalter, William A . Gooch, Matt S. Burkins, Victoria

  20. One Year Out: An Assessment of DADT Repeal’s Impact on Military Readiness

    DTIC Science & Technology

    2012-09-20

    17. LIMITATION OF ABSTRACT Same as Report (SAR) 18 . NUMBER OF PAGES 51 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT...unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39- 18 1 “Repeal… would undermine recruiting...opponents of DADT repeal and to 18 watchdog organizations, including opponents and advocates of repeal, who are known for their ability to monitor

  1. High Performance Computing Contributions to DoD Mission Success 2002

    DTIC Science & Technology

    2003-03-01

    CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT Same as Report (SAR) 18 . NUMBER OF PAGES 194 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b...ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39- 18 Approved for public release...molecular diffusion – 18 – PROTECT BASES OF OPERATION Further applications of the pore-scale simulation have been identified, including the flow of

  2. In Situ Characterization of Point-of-Discharge Fine Particulate Emissions

    DTIC Science & Technology

    2008-07-01

    of Point- of -Discharge Fine Particulate Emissions 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6... NUMBER OF PAGES 163 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form... number of weapons systems. A number of Ft. Sill’s training ranges were projected to be in use during the last half of March, 2007 through

  3. Shakedown & Determination of Tunnel Control Settings for Refurbished Trisonic Gasdynamic Facility (TGF)

    DTIC Science & Technology

    2006-09-01

    the flow calibration, are made of 17 - 4PH stainless steel heat treated to 180-200ksi. Due to the hardness of the wedge, it was assumed to be 17 - 4PH ...Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified 17 . LIMITATION OF ABSTRACT: SAR 18. NUMBER OF PAGES 98 Julie E...16 12. New subsonic diffuser wall settings as shown on three segments ........................ 17 13. Vane change verses

  4. The Army Did Not Properly Account For and Manage Force Provider Equipment in Afghanistan

    DTIC Science & Technology

    2014-07-31

    1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for...RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std...and dining facilities, hygiene services, and morale, welfare and recreation facilities. FP modules accommodate up to 600 personnel and can also be

  5. Novel Active Transient Cooling Systems

    DTIC Science & Technology

    2010-05-04

    NOVEL ACTIVE TRANSIENT COOLING SYSTEMS PI: R.V. Ramanujan Co-PI: P. Keblinski*, G. Ramanath*, E.V. Sampathkumaran^ School of Materials...PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Raju Ramanujan 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND...Report (SAR) 18. NUMBER OF PAGES 13 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified

  6. Nonlinear Interactions between Laser Radiation and Spin-Aligned Carriers in Semiconductors.

    DTIC Science & Technology

    1980-11-25

    Massachusetts 02154 AIR FORCE OFFICEK OF SCIWMTIFIC RESWACHi (AISC) NOTICE OF TRJAZSMITTAL TO DDC This techniical raouti has been reviewed an I approved...f’or PuAli release JAN A.FR 190-12 (7b). Distribution is wilimited. &. D. BLOSA Technical Inorwatiom Oftlee UNCLASSIFIED SECURITY CLASSIFICATION OF...well. The material of choice D I 1473 UNCLASSIFIED.6- SECURITY CLASSIFICATION OF THIS PAGE (mien Deta Entered) UNCLASSIFIED SECURITY CLASSIFICATION OF

  7. Collective Training and Fielding Opportunities for the Objective Force Maneuver Systems at the Unit of Action Level in a Unit Manning/Unit Replacement Personnel System

    DTIC Science & Technology

    2003-04-07

    PERSON Rife, Dave RifeD@awc.carlisle.army.mil a. REPORT Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified 19b. TELEPHONE NUMBER International...38 WORD COUNT = 8975 39 40 ENDNOTES 1 COL Pete Zielinski , Director, Joint/Army concepts HQs TRADOC “Transformation Update” briefing slide #9, Briefing...Staff. Interviewed by author, 18 February 2003, Carlisle Barracks, PA. Zielinski , Pete, COL Director, Joint/Army concepts HQs TRADOC “Transformation

  8. The National Shipbuilding Research Program. Gainsharing-Employee Involvement in a Shipyard/Assembly Yard

    DTIC Science & Technology

    1987-06-01

    Administration and U.S. NAVY in cooperation with Bethlehem Steel Corporation Marine Construction Division Report Documentation Page Form ApprovedOMB No...0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour per response , including the time for reviewing... RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39

  9. Distributed RF Tomography for Tunnel Detection: Suitable Inversion Schemes

    DTIC Science & Technology

    2009-01-01

    methods, ranging from seismic to electromagnetic waves, or from gravity to optics, from impedance tomography to magnetotellurics, no technique...unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Borehole GPR, which may...one manner to different targets (when targets are well-resolved). In particular, the wavefront generated by the array , when excited by one of these

  10. AFLCMC Cd and Cr Replacement/Elimination Strategy

    DTIC Science & Technology

    2014-11-18

    Dominant Air Power: Design For Tomorrow…Deliver Today Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the...REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Product...Airworthiness Process for Deploying New or Substitute Materials, Processes, and Product Forms 2 Abatement Costs • In Nov 2012, SECAF directed the AF find

  11. Towards a Possible Therapy for Diabetes Complications

    DTIC Science & Technology

    2016-03-01

    official Department of the Army position, policy or decision unless so designated by other documentation. REPORT DOCUMENTATION PAGE Form Approved...NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE March 2016 2. REPORT TYPE Addendum to Final 3. DATES COVERED 28 Sept 2014 - 31 Dec 2015...Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified UU 13 19b. TELEPHONE NUMBER (include area code) Standard Form 298 (Rev. 8-98

  12. Non-Destructive Inspection by Infrared Imaging Spectroscopy. Phase 1

    DTIC Science & Technology

    1994-10-14

    light, the AOTF through its birefrengence , the LCD through an entrance polarizer necessary for proper operation. Hence, these devices provide a fixed...through atmosphere of transmission Ta(X), but without any spectral filtering is 20 UNCLASSIFIED I I UNCLASSIFIED P(A) = ~A) , A1 T.(1) T...UNCLASSIFIED dependent on the signal level. Atmospheric transmission is assumed to be from a three meter path at sea-level. Target radiance comprises

  13. Infusing Early Childhood Mental Health into Early Intervention Services

    ERIC Educational Resources Information Center

    Grabert, John C.

    2009-01-01

    This article describes the process of enhancing early childhood mental health awareness and skills in non-mental health staff. The author describes a pilot training model, conducted the U.S. Army's Early Intervention Services, that involved: (a) increasing early childhood mental health knowledge through reflective readings, (b) enhancing…

  14. High serum matrix metalloproteinase 3 is characteristic of patients with paraneoplastic remitting seronegative symmetrical synovitis with pitting edema syndrome.

    PubMed

    Origuchi, Tomoki; Arima, Kazuhiko; Kawashiri, Shin-Ya; Tamai, Mami; Yamasaki, Satoshi; Nakamura, Hideki; Tsukada, Toshiaki; Aramaki, Toshiyuki; Furuyama, Masako; Miyashita, Taiichiro; Kawabe, Yojiro; Iwanaga, Nozomi; Terada, Kaoru; Ueki, Yukitaka; Fukuda, Takaaki; Eguchi, Katsumi; Kawakami, Atsushi

    2012-08-01

    Recently, it was reported that remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome could be complicated with solid tumors. In a retrospective, multicenter study between October, 2003 and September, 2010, we investigated the characteristics of patients with paraneoplastic RS3PE syndrome who fulfilled following criteria: (1) bilateral pitting edema of hands or feet or both, (2) sudden onset of polyarthritis, and (3) age >50 years, (4) seronegativity for rheumatoid factor (RF). A total of 33 cases fulfilled the above criteria. Eight patients (seven men and one woman) developed cancer within 2 years of RS3PE syndrome onset. There was no significant difference between the neoplastic and nonneoplastic groups in the proportions of patients with fever, symmetrical polyarthritis, pitting edema, and good response to corticosteroids. Serum matrix metalloproteinase 3 (MMP-3) level (median 437.3 ng/ml) in the paraneoplastic RS3PE patients was significantly higher than that in patients without neoplasia (median 114.7 ng/ml) (p < 0.05). We found that high serum MMP-3 is characteristic of patients with paraneoplastic RS3PE syndrome.

  15. Early Literacy and Early Numeracy: The Value of Including Early Literacy Skills in the Prediction of Numeracy Development

    ERIC Educational Resources Information Center

    Purpura, David J.; Hume, Laura E.; Sims, Darcey M.; Lonigan, Cristopher J.

    2011-01-01

    The purpose of this study was to examine whether early literacy skills uniquely predict early numeracy skills development. During the first year of the study, 69 3- to 5-year-old preschoolers were assessed on the Preschool Early Numeracy Skills (PENS) test and the Test of Preschool Early Literacy Skills (TOPEL). Participants were assessed again a…

  16. Analysis of the Fragmentation of AlON and Spinel Under Ballistic Impact

    DTIC Science & Technology

    2013-05-01

    Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty...PAGES 11 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98...penetration could not be clearly observed with the other types of spinel tested. This finding corresponds to the lower residual penetration and lower

  17. The U.S. Navy in the World (1981-1990): Context for U.S. Navy Capstone Strategies and Concepts

    DTIC Science & Technology

    2011-12-01

    shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1...NAME OF RESPONSIBLE PERSON a . REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by...ANSI Std Z39-18 CNA is a not-for-profit organization whose professional staff of over 700 provides in-depth analysis and results-oriented solutions

  18. CNIPA, FUB and University of Rome Tor Vergata at TREC 2008 Legal Track

    DTIC Science & Technology

    2008-11-01

    We have only taken part in the automatic ad hoc task of the TREC Legal track 2008, and focused on the following issues: 1. Indexing. The CDIP test...Document Information Processing ( CDIP ) test collection is based on a snapshot of the Tobacco Master Settlement Agreement (MSA) sub-collection of the...unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 The CDIP collection

  19. Homeland Security: A Selected Bibliography

    DTIC Science & Technology

    2011-04-01

    ProQuest Witzleb, Robert W., and Scott C . Truver. "Not Just a Bad Hair Day." [underwater mines] Proceedings: U.S. Naval Institute 134, no. 10...SAR) 18. NUMBER OF PAGES 35 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified...IP_15_09_MigrationAndBorderSecurity.pdf Haddal, Chad C . Border Security: Key Agencies and Their Missions. Washington, DC: Library of Congress, Congressional Research Service

  20. Development of a Polymerase Chain Reaction Assay for the Specific Identification of Burkholderia mallei and Differentiation from Burkholderia pseudomallei and Other Closely Related Burkholderiaceae

    DTIC Science & Technology

    2005-11-29

    used in this work were grown in LB broth. C . violaceum and Y. pestis were propagated at 25 8C, whereas the remaining bacterial isolates were cultured...reference panel, which includ- ed B. cepacia, B. cenocepacia, B. stabilis, B. multivorans, B. vietnamiensis, E. coli, C . violaceum , Y. pestis, and P...19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98

  1. Assessment of Multiple Scattering Errors of Laser Diffraction Instruments

    DTIC Science & Technology

    2003-03-17

    estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the...not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1 . REPORT DATE (DO-MM-YYYY) 2. REPORT TYPE 3...Benner a. REPORT b. ABSTRACT c. THIS PAGE 19b. TELEPHONE NUMBER A (include area code) Unclassified Unclassified Unclassified 1 (661) 275-5693 Standard Form

  2. Demonstration of Laser-Induced Fluorescence on Krypton Hall Effect Thruster

    DTIC Science & Technology

    2011-08-10

    5b. GRANT NUMBER Thruster 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) William A. Hargus Jr., Gregory X. Azarnia, and Michael R. Nakles 5d. PROJECT... William A. Hargus, Jr. a. REPORT Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified SAR 13 19b. TELEPHONE NUMBER (include...Thruster William A. Hargus, Jr.∗ Gregory M. Azarnia† Michael R. Nakles‡ Air Force Research Laboratory, Edwards Air Force Base, CA 93524 There is growing

  3. Does Your Culture Encourage Innovation?

    DTIC Science & Technology

    2015-04-01

    any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a...NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by...customary beliefs, social forms, and material traits of a racial, religious, or social group” (Culture, 1990, p. 314). The DoD’s culture is influenced

  4. Peer Reviewed Cancer Research Program Fiscal Year 2012 Report to Congress

    DTIC Science & Technology

    2012-02-21

    ABSTRACT Same as Report (SAR) 18 . NUMBER OF PAGES 24 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS...PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39- 18 Peer Reviewed Cancer Research Program Fiscal Year 2012 Report to...Epidemiol Biomarkers Prev 18 :1740-1745 10. Ajene A, Bohnker B, Malakooti MA, Riegodedios A, and Sack DM. 2004. Neoplasms in the Navy, 1998-2000

  5. Can EDA Combat the Rise of Electronic Counterfeiting?

    DTIC Science & Technology

    2012-06-01

    Categories and Subject Descriptors B .7 [Hardware]: Integrated Circuits General Terms Design, Security Keywords Counterfeiting; Reliability; Device and...1199-1/12/06 ...$10.00. SIA at $7.5 B . Very recently, EE Times estimated that IC counterfeiting losses are as high as $ 169 B annually. There- fore, the...PERSON a. REPORT unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18

  6. Rapid Trust Establishment for Transient Use of Unmanaged Hardware

    DTIC Science & Technology

    2006-12-01

    unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Keywords: Establishing...Validate OS Trusted Host OS (From Disk) Validate App 1 Untrusted code Trusted code (a) Boot with trust initiator ( b ) Boot trusted Host OS (c) Launch...be validated. Execution of process with Id 3535 has been blocked to minimize security risks. ( b ) Notification to the user from the trust alerter

  7. A Comparison of the Joint Maritime Command Information System (JMCIS) capabilities with the United States Marine Corps (USMC) Advanced Tactical Air Command Center (ATACC) Data Link Requirements

    DTIC Science & Technology

    1994-09-01

    Ian -t-R Todd Franklin Sweeney_ September, 1994 Thesis Advisor: Carl R. Jones Approved for public release; distribution is unlimited. M . , -" &D I...AGENCY REPORT NUMBER tion of the Department of Defense or the U.S. Government. 12a. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; 12b...Unclassified Unclassified Unclassified NSN 7540-01-280-5500 Standard Form 298 (Rev. 2-89) Prescribed by ANSI Std 239-18 Approved for public release; distribution

  8. DDG 51 Arleigh Burke Class Guided Missile Destroyer (DDG 51)

    DTIC Science & Technology

    2015-12-01

    Selected Acquisition Report ( SAR ) RCS: DD-A&T(Q&A)823-180 DDG 51 Arleigh Burke Class Guided Missile Destroyer (DDG 51) As of FY 2017 President’s...Budget Defense Acquisition Management Information Retrieval (DAMIR) UNCLASSIFIED DDG 51 December 2015 SAR UNCLASSIFIED 2 Table of Contents Common Acronyms...Defense O&S - Operating and Support PAUC - Program Acquisition Unit Cost DDG 51 December 2015 SAR UNCLASSIFIED 3 PB - President’s Budget PE - Program

  9. Naval Response to a Changed Security Environment: Maritime Security in the Mediterranean

    DTIC Science & Technology

    2007-01-01

    other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a...PAGES 28 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8...elements. The first was to use inflatable Zodiac -type speedboats to attack ships. The second was to blow up medium-sized vessels near other ships

  10. Joint Center for Operational Analysis Quarterly Bulletin. Volume 8, Issue 2, June 2006

    DTIC Science & Technology

    2006-06-01

    aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if...OF PAGES 72 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev...reaches out across the Department of Defense to handle all IED related inquires. As the capability continues to mature and improve, the long term

  11. Angle Dependent Optics of Plasmonic Core-Shell Nanoparticles

    DTIC Science & Technology

    2018-02-21

    RESEARCH Final Report 02/21/2018 DISTRIBUTION A: Distribution approved for public release. AF Office Of Scientific Research (AFOSR)/ IOA Arlington...Virginia 22203 Air Force Research Laboratory Air Force Materiel Command   a. REPORT Unclassified   b. ABSTRACT Unclassified   c. THIS PAGE Unclassified...EDUCATION AND RESEARCH 900, NCL Innovation Park, Dr Homi Bhabha Road, Pashan PUNE, 411008 IN 8.  PERFORMING ORGANIZATION      REPORT NUMBER 9

  12. A Computational Approach for Automated Posturing of a Human Finite Element Model

    DTIC Science & Technology

    2016-07-01

    Std. Z39.18 July 2016 Memorandum Report A Computational Approach for Automated Posturing of a Human Finite Element Model Justin McKee and Adam...protection by influencing the path that loading will be transferred into the body and is a major source of variability. The development of a finite element ...posture, human body, finite element , leg, spine 42 Adam Sokolow 410-306-2985Unclassified Unclassified Unclassified UU ii Approved for public release

  13. Description and Evaluation of GDEM-V 3.0

    DTIC Science & Technology

    2009-02-06

    Description and Evaluation of GDEM -V 3.0 Michael R. caRnes Ocean Sciences Branch Oceanography Division February 6, 2009 i REPORT DOCUMENTATION PAGE Form...include area code) b. ABSTRACT c. THIS PAGE 18. NUMBER OF PAGES 17. LIMITATION OF ABSTRACT Description and Evaluation of GDEM -V 3.0 Michael R. Carnes...unlimited. Unclassified Unclassified Unclassified UL 24 Michael R. Carnes (228) 688-5648 The GDEM (Generalized Digital Environment Model) has served as

  14. A Quantitative Approach to Analyzing Architectures in the Presence of Uncertainty

    DTIC Science & Technology

    2009-07-01

    SAR) 18. NUMBER OF PAGES 33 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified Standard...hence requires appropriate tool support. 3 3.1 Architecture Modeling To facilitate this form of modeling, the modeling language must allow the archi ...can (a) capture the steady-state behavior of the model, ( b ) allow for the analysis of some property in the context of a specific state or condition

  15. The National Shipbuilding Research Program. 1988 Ship Production Symposium, Paper No. 2B: An Integrated CAD/CAM Network for Work Packaging Development and Database Management

    DTIC Science & Technology

    1988-08-01

    notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a...19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98...States Navy, nor any person acting on behalf of the United States Navy (A) makes any warranty or representation, expressed or implied, with respect

  16. Kr II Laser-Induced Fluorescence for Measuring Plasma Acceleration (Preprint)

    DTIC Science & Technology

    2012-02-01

    Unclassified b. ABSTRACT Unclassified c. THIS PAGE Unclassified SAR 13 19b. TELEPHONE NUMBER (include area code) N /A Standard Form 298 (Rev. 8...thruster operation was measured with a cold cathode ionization gauge to be 1×10−3 Pa, corrected for krypton (N2 conversion to Kr pressure multiplicative...the breathing mode oscillation is correlated to the width of the veloc- ity distributions. Therefore, reducing discharge channel plasma turbulence will

  17. Hotline Allegation Regarding the Failure of Defense Contract Management Agency Philadelphia to Settle an Audit of a Significant Cost Accounting Change

    DTIC Science & Technology

    2011-03-22

    be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of...NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed...processed data as part of our review. Prior Coverage In the last 5 years, we have issued five other reports on DCMA contracting officer actions in

  18. Armed Conflict in Syria: U.S. and International Response

    DTIC Science & Technology

    2012-08-21

    provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently...NUMBER OF PAGES 42 19a. NAME OF RESPONSIBLE PERSON a . REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form...timetables for a resolution to Syria’s ongoing crisis. In the face of intense domestic and international pressure calling for political change and for an

  19. Optimizing Internal Wave Drag in a Forward Barotropic Model with Semidiurnal Tides

    DTIC Science & Technology

    2015-01-23

    Center 875 North Randolph Street, Suite 1425 Arlington, VA 22203-1995 ONR Approved for public release, distribution is unlimited. A global tuning...factor with a larger value in the Atlantic. Our best global mean RMS error of 4.4 cm for areas deeper than 1000 m and equatorward of 66_ is among the...lowest obtained in a forward barotropic tide model. Barotropic tides; Global modeling; Linear wave drag Unclassified Unclassified Unclassified UU

  20. As Simple as Possible, But No Simpler: A Gentle Introduction to Simulation Modeling

    DTIC Science & Technology

    2006-12-01

    cultures, people waiting for a bus mimic the concept by standing in a row. However, there are some cultures where no line forms but it is considered...mathematical equations such as the equations of motion Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the...PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18

  1. Chairman of the Joint Chiefs of Staff Strategy Essay Competition: Essays 1999

    DTIC Science & Technology

    1999-08-01

    notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a...NUMBER OF PAGES 102 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form... person " or of publishing ’%mtruths." It also prohibited local broadcasters from the common practice of rebroadcasting foreign programs, in effect

  2. Department of Defense September 2003 Adult Poll 5 Overview Report

    DTIC Science & Technology

    2004-04-01

    Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for...ABSTRACT UU 18. NUMBER OF PAGES 107 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified...foreign affairs. Chance of Combat Adults believe that there is almost a two-thirds chance (64%) that a young person who entered the military today

  3. Removing Full-scale Testing Barriers: Energetic Material Detonation Characterization at the Laboratory Scale

    DTIC Science & Technology

    2012-03-01

    3708Unclassified Unclassified Unclassified ii Contents List of Figures iv List of Tables v Acknowledgments vi 1. Introduction 1 2. Theory/ Methodology ...Theory/ Methodology A shock wave is fully defined through knowledge of five state variables: shock pressure P , shock velocity U , particle velocity u...DIRECTOR US ARMY RESERACH LAB RDRL D 2800 POWDER MILL RD ADELPHI MD 20783-1197 21 NO. OF NO. OF COPIES ORGANIZATION COPIES ORGANIZATION 3 US ARMY RSRCH OFC

  4. Modeling Large-Scale Networks Using Virtual Machines and Physical Appliances

    DTIC Science & Technology

    2014-01-27

    downloaded and run locally. The lab solution couldn’t be based on ActiveX because the military Report Documentation Page Form ApprovedOMB No. 0704-0188...unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 disallowed ActiveX support on...its systems, which made running an RDP client over ActiveX not possible. The challenges the SEI encountered in delivering the instruction were

  5. Nonequilibrium Hypersonic Aerothermodynamics Using the Direct Simulation Monte Carlo And Navier-Stokes Models

    DTIC Science & Technology

    2008-01-17

    15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT UU 18 . NUMBER OF PAGES 261 19a. NAME OF RESPONSIBLE PERSON a...REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39- 18 This material...Sciences Meeting and Exhibit. Several DSMC [13, 58] and CFD [ 18 , 28, 43] solutions were submitted. Later, others compared CFD and DSMC solutions to these

  6. Comparison Between Self-Guided Langevin Dynamics and Molecular Dynamics Simulations for Structure Refinement of Protein Loop Conformations

    DTIC Science & Technology

    2011-01-01

    SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT Same as Report (SAR) 18 . NUMBER OF PAGES 9 19a. NAME OF RESPONSIBLE PERSON a. REPORT...unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39- 18 sampling is based on...atom distance-scaled ideal-gas reference state (DFIRE-AA) statistical potential func- tion.[ 18 ] The third approach is the Rosetta all-atom energy func

  7. Collision Dynamics of O(3P) + DMMP Using a Specific Reaction Parameters Potential Form

    DTIC Science & Technology

    2012-01-27

    CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT Same as Report (SAR) 18 . NUMBER OF PAGES 14 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified...b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39- 18 Collision Dynamics of O(3P...SRP POTENTIAL Although there have been great strides in developing accurate, multidimensional, global potential energy surfaces, 18 −24 mole- cules with

  8. Non-Traditional Commercial Defense Contractors

    DTIC Science & Technology

    2013-11-01

    law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB...NUMBER OF PAGES 109 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298... five to seven years, the acquisition environment at the DoD for non-traditional commercial contractors has eroded significantly. There is a

  9. Viral Etiologies of Lower Respiratory Tract Infections Among Egyptian Children under Five Years of Age

    DTIC Science & Technology

    2012-12-13

    Infectious Diseases © 2012 Shafik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http... SAR ) 18. NUMBER OF PAGES 19 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified...in FLUAV burden between the two studies, particularly because the Tang et al. and Zhang et al. studies tested children up to 16 years of age. Other

  10. Optical 3-Way Handshake (O3WHS) Protocol Simulation in OMNeT++

    DTIC Science & Technology

    2017-06-01

    PERSON Vinod K Mishra a. REPORT Unclassified b. ABSTRACT Unclassified c . THIS PAGE Unclassified 19b. TELEPHONE NUMBER (Include area code) 410...popular program called OMNeT++2 for that purpose. It is an open-source discrete event simulator tool written in C ++ language. It has been chiefly...References 1. Von Lehmen A, Doverspike R, Clapp G, Freimuth DM, Gannett J, Kolarov A, Kobrinski H, Makaya C , Mavrogiorgis E, Pastor J, Rauch M

  11. The Army’s Green Warriors: Environmental Considerations in Contingency Operations

    DTIC Science & Technology

    2008-01-01

    NUMBER OF PAGES 5 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form 298...Rev. 8-98) Prescribed by ANSI Std Z39-18 Th e relationship between the Army and the environment is a two-way street. On the one hand , soldiers and...poor sanitation can cause debilitating shorter-term illness and can also sometimes cause longer-term health problems, such as increased cancer

  12. Building Self-configuring Services Using Service-specific Knowledge

    DTIC Science & Technology

    2004-12-01

    no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control...OF PAGES 180 19a. NAME OF RESPONSIBLE PERSON a . REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev...Abstract Network applications such as Web browsing, video conferencing, instant messaging, file sharing, and online gaming are becoming a necessity for more

  13. Intelligent Signal Processing for Active Control

    DTIC Science & Technology

    1992-06-17

    FUNDING NUMSI Intelligent Signal Processing for Active Control C-NO001489-J-1633 G. AUTHOR(S) P.A. Ramamoorthy 7. P2RFORMING ORGANIZATION NAME(S) AND...unclassified .unclassified unclassified L . I mu-. W UNIVERSITY OF CINCINNATI COLLEGE OF ENGINEERING Intelligent Signal Processing For Rctiue Control...NAURI RESEARCH Conkact No: NO1489-J-1633 P.L: P.A.imoodh Intelligent Signal Processing For Active Control 1 Executive Summary The thrust of this

  14. Tied Mixtures in the Lincoln Robust CSR

    DTIC Science & Technology

    1989-01-01

    reporting burden for the collection of information is estimated to average 1 hour per response , including the time for reviewing instructions, searching...TITLE AND SUBTITLE Tied Mixtures in the Lincoln Robust CSR 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...ABSTRACT 18. NUMBER OF PAGES 10 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified

  15. Review of Audits Issued by the Defense Contract Audit Agency in FY 2012 and FY 2013

    DTIC Science & Technology

    2014-09-08

    Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour per response...RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI...which the Iraq Branch Office examined in 2007, and whose costs were suspended on DCAA Form 1 Notice No. 135 and negotiated by the cognizant ACO on

  16. Effective Management of Hexavalent Chromium (Cr+6) in DoD Organic and Inorganic Coatings Operations

    DTIC Science & Technology

    2014-11-19

    stropki@battelle.org 614-424-5414 ASETSDefense 2014 November 19, 2014 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting...19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98...Determine impacts of HCR on select aerospace substrates - ferrous (1020 CS and 4340 HSS ), non-ferrous (Al 2024-T3, Al7075-T6, and Mg AZ31B-H24

  17. Development of Nanomedicines for Treatment of Posttraumatic Osteoarthritis

    DTIC Science & Technology

    2015-07-01

    Department of the Army position, policy or decision unless so designated by other documentation. REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704... FORM TO THE ABOVE ADDRESS. 1. REPORT DATE July 2015 2. REPORT TYPE Annual 3. DATES COVERED 5 June 2014 – 4 Jun 2015 4. TITLE AND SUBTITLE...Unclassified c. THIS PAGE Unclassified Unclassified 19b. TELEPHONE NUMBER (include area code) Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std

  18. Reversible ovulatory failure associated with the development of luteinized unruptured follicles in women with inflammatory arthritis taking non-steroidal anti-inflammatory drugs.

    PubMed

    Smith, G; Roberts, R; Hall, C; Nuki, G

    1996-05-01

    The case histories of three young women with ankylosing spondylitis, rheumatoid arthritis and a seronegative inflammatory polyarthritis undergoing investigations for infertility are presented. In each, non-steroidal anti-inflammatory drug (NSAID) therapy was associated with the recurrent development of luteinized unruptured ovarian follicles and normal ovulation following drug withdrawal. It is suggested that NSAID therapy may be an important and frequently overlooked cause of anovulation and infertility.

  19. Clinical predictors of response and discontinuation of belimumab in patients with systemic lupus erythematosus in real life setting. Results of a large, multicentric, nationwide study.

    PubMed

    Iaccarino, Luca; Andreoli, Laura; Bocci, Elena Bartoloni; Bortoluzzi, Alessandra; Ceccarelli, Fulvia; Conti, Fabrizio; De Angelis, Rossella; De Marchi, Ginevra; De Vita, Salvatore; Di Matteo, Andrea; Emmi, Giacomo; Emmi, Lorenzo; Gatto, Mariele; Gerli, Roberto; Gerosa, Maria; Govoni, Marcello; Larosa, Maddalena; Meroni, Pier Luigi; Mosca, Marta; Pazzola, Giulia; Reggia, Rossella; Saccon, Francesca; Salvarani, Carlo; Tani, Chiara; Zen, Margherita; Frigo, Anna Chiara; Tincani, Angela; Doria, Andrea

    2018-01-01

    To investigate efficacy, safety and survival of belimumab and to identify predictors of drug response and drug discontinuation in patients with active SLE in clinical practice. Data of SLE patients, treated with belimumab, from 11 Italian prospective cohorts were analyzed. SLEDAI-2K, anti-dsDNA, C3, C4, prednisone daily dose, DAS-28, 24-h proteinuria, CLASIa (Cutaneous LE Disease Area and Severity Index Activity) were recorded at baseline and every 6 months. SLE Responder Index-4 (SRI-4) was calculated at 12 and 24 months. Demographic and clinical features and comorbidities were included in the univariate and multivariate analysis. Adverse events were recorded at each visit. Statistics was performed using the SPSS software. We studied 188 SLE patients, mean follow-up 17.5 ± 10.6 months. The most frequent manifestations, which required the use of belimumab, were polyarthritis (45.2%) and skin rashes (25.5%). SRI-4 was achieved by 77.0% and 68.7% of patients at 12 and 24-months. Independent predictors of 12-month response were SLEDAI-2K ≥ 10 (OR 40.46, p = 0.001) and polyarthritis (OR 12.64, p = 0.001) and of 24-month response were SLEDAI-2K ≥ 10 (OR 15.97, p = 0.008), polyarthritis (OR 32.36, p = 0.006), and prednisone ≥7.5 mg/day (OR 9.94, p = 0.026). We observed a low rate of severe adverse events. Fifty-eight patients (30.8%) discontinued belimumab after a mean follow-up of 10.4 ± 7.5 months. The drug survival was 86.9%, 76.9%, 69.4%, 67.1%, and 61.9% at 6, 12, 18, 24, and 30 months, respectively. No factors associated with drug discontinuation were found. Belimumab is effective and safe when used in clinical practice setting. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Corner Polyhedron and Intersection Cuts

    DTIC Science & Technology

    2011-03-01

    any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a...19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98... finding valid inequalities for the set (1) that are violated by the point x̄. Typically, x̄ is an optimal solution of the linear programming (LP

  1. Geometrical and Topological Methods in Time Domain Antenna Synthesis

    DTIC Science & Technology

    1994-04-30

    94 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS GEOMETRICAL & TOPOLOGICAL METHODS IN TIME DOMAIN ANTENNA SYNTHESIS (U) 6. AUTHOR(S) j 61102F i 2304/BS...34 UNCLASSIFIED UNCLASSIFIED j UNCLASSIFIED SAR(SAME AS REPORT) -. Final Technical Report Grant F49620-92-J-0056 Geometrical and Topological Methods in Time...Morse theory, we may try to relate Witten’s proof of the Morse inequalities[92’, the heat equation method for harmonic forms[30], in the context of

  2. The Limits of Military Officers’ Duty to Obey Civilian Orders: A Neo-classical Perspective

    DTIC Science & Technology

    2015-07-01

    subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE...Orders: A Neo-classical Perspective 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK...73 19a. NAME OF RESPONSIBLE PERSON a . REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98

  3. Genotoxic Changes to Rodent Cells Exposed in Vitro to Tungsten, Nickel, Cobalt and Iron

    DTIC Science & Technology

    2014-03-10

    SAR) 18. NUMBER OF PAGES 20 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified...37 ° C in a humidified atmosphere of 5% CO2 in air. Cultures were routinely fed every 3–4 days, and passaged weekly. Experiments were conducted...Samples were stored at −80 ° C until needed. 2.4. Microarray Analysis RNA samples were sent to the Genomics Core of the Lerner Research Institute at the

  4. Receptivity of a Cryogenic Coaxial Liquid Jet to Acoustic Disturbances

    DTIC Science & Technology

    2014-01-01

    PAGES 19a. NAME OF RESPONSIBLE PERSON D. Talley a. REPORT Unclassified b. ABSTRACT Unclassified c . THIS PAGE Unclassified SAR 13 19b... c pu c    (1) where u’ is the magnitude of the velocity fluctuation in the velocity antinode region, p’ is the magnitude of the pressure...fluctuation in the pressure antinode region,  c is the density of the ambient gas in the chamber, which is nominal room temperature nitrogen, and c

  5. Insider Threats: DOD Should Strengthen Management and Guidance to Protect Classified Information and Systems

    DTIC Science & Technology

    2015-06-01

    REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 United...GAO-15-544. For more information, contact Joseph W. Kirschbaum at (202) 512- 9971 or kirschbaumj@gao.gov or Gregory C . Wilshusen at (202) 512-6244 or...Joseph W. Kirschbaum at (202) 512-9971 or KirschbaumJ@gao.gov or Gregory C . Wilshusen at (202) 512-6244 or WilshusenG@gao.gov. Contact points for

  6. Acute Traumatic Coagulopathy: Whole Blood Thrombelastography Measures the Tip of the Iceberg

    DTIC Science & Technology

    2015-01-01

    with the thromboelastography analyser. Blood Coagul Fibrinolysis. 2009;20(6):436Y439. 14. Engstrom M , Schott U, Romner B , Reinstrup P. Acidosis impairs...PAGES 7 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98...and 10KL) of 1- M 2-[morpholino]ethanesulfonic acidYbuffered saline (MBS) to a 300-KL volume sample in the TEG cup (Table 1). MBS was chosen for its

  7. Pulsed Power Education

    DTIC Science & Technology

    1983-06-01

    JUN 1983 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Pulsed Power Education 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...1976-2013, and Abstracts of the 2013 IEEE International Conference on Plasma Science. Held in San Francisco, CA on 16-21 June 2013. U.S. Government or...unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 PULSED POWER EDUCATION * M

  8. Armenia, Azerbaijan, and Georgia: Security Issues and Implications for U.S. Interests

    DTIC Science & Technology

    2009-01-14

    might be drawn by their ties with Turkey into policy imbroglios. Some in Turkey have envisaged Azerbaijan and Central Asia as part of a pan- Turanic ...be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT...NUMBER OF PAGES 65 19a. NAME OF RESPONSIBLE PERSON a . REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298

  9. Armenia, Azerbaijan, and Georgia: Political Developments and Implications for U.S. Interests

    DTIC Science & Technology

    2007-07-31

    should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of...information if it does not display a currently valid OMB control number. 1. REPORT DATE 31 JUL 2007 2. REPORT TYPE N/ A 3. DATES COVERED - 4...PERSON a . REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18

  10. Composable Flexible Real-time Packet Scheduling for Networks on-Chip

    DTIC Science & Technology

    2012-05-16

    unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Copyright © 2012...words, real-time flows need to be composable. We set this as the design goal for our packet scheduling discipline developed in this paper. B . Motivating...with closest deadline is chosen to forward to the next router. B . Traffic Model We assume a traffic model for real-time flows similar to the one used

  11. The Counterproductive Sea of Sameness in PME

    DTIC Science & Technology

    2014-01-01

    RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18...range between 7.3 and 15 percent, decreasing at senior Service schools where fewer women meet the rank qualifications .7 At the U.S. Army War...great librarians .” The student noted too that although a large number of class-wide lectures had already occurred, only two women were among the

  12. Reassessing the Barriers to Islamic Radicalization in Kazakhstan

    DTIC Science & Technology

    2015-07-01

    subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE...RESPONSIBLE PERSON a . REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39...the U.S. Army to also act as a “think factory” for commanders and civilian leaders at the strategic level worldwide and routinely engage in discourse

  13. Femme Fatale: An Examination of the Role of Women in Combat and the Policy Implications for Future American Military Operations (Drew Paper Number 5, August 2009)

    DTIC Science & Technology

    2009-08-01

    subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE...NUMBER OF PAGES 137 19a. NAME OF RESPONSIBLE PERSON a . REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form...298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Air University Allen G. Peck, Lt Gen, Commander Air Force Research Institute John A . Shaud, Gen, PhD

  14. Nigeria

    DTIC Science & Technology

    2010-02-12

    notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not...display a currently valid OMB control number. 1. REPORT DATE 12 FEB 2010 2. REPORT TYPE 3. DATES COVERED 00-00-2010 to 00-00-2010 4. TITLE AND...19a. NAME OF RESPONSIBLE PERSON a . REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98

  15. Maneuvering the Islamist-Secularist Divide in the Arab World: How the United States Can Preserve Its Interests and Values in an Increasingly Polarized Environment

    DTIC Science & Technology

    2014-10-01

    should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of...information if it does not display a currently valid OMB control number. 1. REPORT DATE OCT 2014 2. REPORT TYPE 3. DATES COVERED 00-00-2014 to 00...NUMBER OF PAGES 65 19a. NAME OF RESPONSIBLE PERSON a . REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298

  16. Reduction of a Class of Fox-Wright PSI Functions for Certain Rational Parameters

    DTIC Science & Technology

    1995-01-01

    a. REPORT unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 1...evidently with Lambert (1758). Numerous other investigators studied them, notably Lagrange (1770), Heymann (1887), Capelli (1892), Ramanujan (circa...per unit time, that can be transmitted over the channel is called the capacity C and is de ned by C = limsupn!1 log2 n q jSnj : (6:1) The original de

  17. HARD PAN I Test Series Test and Instrumentation Plans. Volume I. Test Plan

    DTIC Science & Technology

    1975-12-01

    t.jw .y..,,^.,^,. Ä!»,,«-* :,,; .trwev* ’ UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGt ’Wh&n Data Entered) J?)REPORT DOCUMENTATION PAGE...to facility-l—> DO ,: FORM A’J 73 1473 EDITION OF 1 NOV 65 15 OBSOLETE UNCLASSIFIED fNW SECURITY CLASSIFICATION OF THIS PAGE (Wfien Data Entered...y^o ... — ppiiw’.^y.-.j-w... v»t \\ UNCLASSIFIED iCURITY CLASSIFICATION CF THIS PAGEfWlon Data Entered) design, modification, and hardness

  18. World War II Temporary Military Buildings: A Brief History of the Architecture and Planning of Cantonments and Training Stations in the United States

    DTIC Science & Technology

    1993-03-01

    ABSTRACT OF REPORT OF THIS PAGE OF ABSTRACT Unclassified Unclassified Unclassified SAR NSN 7540-01-280-5500 Sidx Form 28 (Rev. 2-0 Precribed b• ANSt Sis 239...assistance. Dr. Robert Kapsch, Chief of the Historic American Buildings Survey and Engineering Record, Washington, and John Burns , Deputy Chief, encouraged...consumed 600,000 board-feet of lumber and 250 window sashes. In 1868,2 years after its founding, the fort was abandoned and then burned by the Sioux. 3.4

  19. Brachytherapy in early prostate cancer--early experience.

    PubMed

    Jose, B O; Bailen, J L; Albrink, F H; Steinbock, G S; Cornett, M S; Benson, D C; Schmied, W K; Medley, R N; Spanos, W J; Paris, K J; Koerner, P D; Gatenby, R A; Wilson, D L; Meyer, R

    1999-01-01

    Use of brachytherapy with radioactive seeds in the management of early prostate cancer is commonly used in the United States. The early experience has been reported from the prostate treatment centers in Seattle for the last 10 years. In this manuscript we are reporting our early experience of 150 radioactive seed implantations in early stage prostate cancer using either Iodine 125 or Palladium 103 seeds. The average age of the patient is 66 years and the median Gleason score is 5.4 with a median PSA of 6. A brief description of the evolution of the treatment of prostate cancer as well as the preparation for the seed implantation using the volume study with ultrasound of the prostate, pubic arch study using CT scan of the pelvis and the complete planning using the treatment planning computers are discussed. We also have described the current technique which is used in our experience based on the Seattle guidelines. We plan a follow-up report with the results of the studies with longer follow-up.

  20. Transient Simulation of a Rotating Conducting Cylinder in a Transverse Magnetic Field

    DTIC Science & Technology

    2016-09-01

    GIDEP Operations Center P.O. Box 8000 Corona , CA 91718-8000 gidep@gidep.org UNCLASSIFIED Approved for public release; distribution is unlimited. UNCLASSIFIED 26 Douglas C. Troast Douglas C. Troast Andrew Pskowski

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