Sample records for early xx century

  1. [The scientific revolution in medicine of second half of XX - early XXI centuries: occurrence of new conceptions about human organism and essence of diseases].

    PubMed

    Stepin, V S; Zatravkin, S N

    2016-01-01

    The article presents the results of analysis of works of supreme Russian physiologists and pathologists of XX-XXI centuries. The analysis was applied on the basis concept of structure and dynamics of scientific cognition developed by one o the authors of the present article. The applied analysis permits affirming that during second half of XX-early XXI centuries in medicine occurred and continues to occurring transformations whose character and scope totally corresponds to scientific revolution and occurring and establishing in medicine new conceptions have all signs permitting referring them to post-neoclassic type of scientific rationality.

  2. [From the history of organization of medical care to population in cities of the north-eastern Caucasus in XIX--early XX centuries].

    PubMed

    2013-01-01

    The article deals with becoming of urban health care in the region of the north-eastern Caucasus in XIX--early XX centuries. The characteristics and stages of development of medical care in cities appeared grew from military fortifications and fortresses in the meddle of XIX century are established. The first curative institutions in cities were military hospitals and infirmaries. Later on appeared clinics of philanthropic societies and even later on hospitals functioning on municipality funds and private curative establishments.

  3. Pedagogical Foundations of Effective Reading Instruction Older Students in Russia in the Late XIX-Early XX Centuries

    ERIC Educational Resources Information Center

    Belentsov, Sergei I.; Malykhina, Olga N.; Ilyina, Irina V.; Mandruk, Irina V.

    2018-01-01

    Topical issues of development of reader's activity of school students are considered on the basis of the comparative analysis of the situation characterizing a technique of formation of communicative competence of the system of gymnasia formation of the Kursk province of the end XIX--the beginning of the XX centuries. The comparative-historical…

  4. [THE IMPROVEMENT OF CITIES AND SANITARY CONTROL IN RUSSIA IN LATE XIX--EARLY XX CENTURIES].

    PubMed

    Sherstneva, E V

    2015-01-01

    The article considers activity of municipal self-governments of Russia concerning support of sanitary epidemiological well-being of cities in the late XIX--early XX centuries. The acuteness of problem of sanitary conditions of urban settlements particularly became visible in post-reform period due to increasing of number of urban population, alteration of setup and rhythm of life in cities, appearance of new forms of worker's daily chores. Al this, against the background of underdevelopment of communal sphere aggravated epidemiological situation in cities. The impulse to improvement and development of sanitary control was made by the city regulations of 1870 presenting to town authorities the right to deal with sanitary issues. The significant input into improvement of cities was made first of all at the expense of construction of water supplies and sewerage and support of sanitary control of these spheres of municipal economy. Under town councils of many cities the sanitary commissions were organized to support permanent sanitary control in town. The development of town sanitation followed the way of specialization. The housing and communal, trade and food, school and sanitary and sanitary and veterinary control were organized.

  5. [The state of obstetrics in the national republics of North Caucasus during the first half of XX century].

    PubMed

    Iakh'iaeva, Z I; Bataev, Kh M

    2011-01-01

    In Caucasus, during the first half of XX century the organization of obstetric gynecological care of women accompanied by significant problems to be resolved in the conditions of burning deficiency of material and manpower resources. In the early 1950s the functioning of the system of obstetrics in the North Caucasus region needed more intensive organizational efforts and highest possible involvement of medical science achievements.

  6. [Enteroviruses in the XX and XXI centuries].

    PubMed

    Seĭbil', V B; Malyshkina, L P

    2005-01-01

    The modern view of the role of enteroviruses in the eradication of poliomyelitis is presented. Enteroviruses were discovered in the XX century. In the 1950s they caused great epidemics of poliomyelitis and serous meningitis in many countries of the world. The introduction of oral poliomyelitis vaccine (OPV) into medical practice made it possible to eliminate the epidemics of poliomyelitis in a short time. Poliomyelitis morbidity was reduced to sporadic cases and in a number of regions disappeared. OPV produced non-specific influence also on the epidemics of serous meningitis, as well as on a case incidence. The eradication of poliomyelitis viruses and the cessation of immunization with OPV will not result in eradication of paralytic diseases. Paralytogenic viruses of 20 serotypes circulate in nature, and some of these viruses are capable of causing the outbreaks of severe paralytic diseases. The authors propose either to retain immunization with OVP as tour immunizations with monovaccine of type 2, or to create new live enterovirus vaccines on the basis of avirulent enterovirus strains.

  7. [THE SOCIAL HYGIENE AS A PHENOMENON OF SCIENTIFIC REVOLUTION IN MEDICINE OF LATE XIX--FIRST HALF XX CENTURIES].

    PubMed

    Schepin, V O; Zatravkin, S N

    2015-01-01

    The article presents results of analysis of works of late XIX--first quarter of XY centuries devoted to problems of social hygiene. It is established that origin of social hygiene was directly related to crucial revision of conceptions of causes and essence of diseases that created necessary conditions for transfer into medicine ideas and methods of political economy, sociology and eugenics. It is proved that origin of social hygiene was appropriate consequence of those crucial alterations in mass physician's consciousness that characterize scientific revolution in medicine of late XIX--first half XX centuries.

  8. Serbian Astronomers in Science Citation Index in the XX Century

    NASA Astrophysics Data System (ADS)

    Dimitrijevic, Milan S.

    "Alpha". In 1996 Zrenjanin too got an organization of amateur astronomers, Astronomical Society "Milutin Milankovic". Moreover, in the book is given a selected bibliography of references concerning the history of astronomy among Serbs in XX century.

  9. Spanish Radiology in the second half of the XX Century: a view from inside.

    PubMed

    Bonmatí, José

    2008-09-01

    Radiology was born in 1896 with the immediate recognition of the diagnostic value of X-rays in medicine and progressed throughout the XX Century with the increasing knowledge of its properties and clinical applications. By mid-century Radiology was a respected clinical specialty in advanced countries, the radiological report was a requirement in hospital practice and radiologists' opinions requested in scientific meetings. In the last decades of the century has had a spectacular expansion with the emergence of new imaging modalities and revolutionary technologies that have transformed the specialty worldwide. In Spain Radiology lagged behind needs and demand in 1950. Radiological practice was unregulated and performance of X-ray exams by non-radiologists was common. Teaching of Radiology was non-existent in Medical Schools or postgraduation. The diagnostic value of the specialty was unrecognized by physicians and the role of radiologists ignored. Most hospital radiology services were poorly equipped and functionally inadequate. The shadow of the Civil War (1936-39) was conditioning Radiology in the country. The point of inflexion in the development of Radiology in Spain was the inclusion of film reading sessions in the 1965 academic program of the Society of Radiology. It was in the presentation of cases at these conferences that Clinical Radiology found the finest demonstration ground and as a result was immediately adopted by radiologists and progressively applied in scientific meetings, clinical practices and training programs. Its influence was important in reforming hospital practice, legislation on specialization and education, as well as in national health care plans. At the end of the century radiology in Spain was at a par with the standards of other western nations. The author was a witness of the evolution of Radiology during his 50 years of professional life. This article does not pretend to be exhaustive in names or contributions. It is an overview of

  10. Subtractive and differential hybridization molecular analyses of Ceratitis capitata XX/XY versus XX embryos to search for male-specific early transcribed genes.

    PubMed

    Salvemini, Marco; D'Amato, Rocco; Petrella, Valeria; Ippolito, Domenica; Ventre, Giuseppe; Zhang, Ying; Saccone, Giuseppe

    2014-01-01

    The agricultural pest Ceratitis capitata, also known as the Mediterranean fruit fly or Medfly, is a fruit crop pest of very high economic relevance in different continents. The strategy to separate Ceratitis males from females (sexing) in mass rearing facilities is a useful step before the sterilization and release of male-only flies in Sterile Insect Technique control programs (SIT). The identification of genes having early embryonic male-specific expression, including Y-linked genes, such as the Maleness factor, could help to design novel and improved methods of sexing in combination with transgenesis, aiming to confer conditional female-specific lethality or female-to-male sexual reversal. We used a combination of Suppression Subtractive Hybrydization (SSH), Mirror Orientation Selection (MOS) anddifferential screening hybridization (DSH) techniques to approach the problem of isolating corresponding mRNAs expressed in XX/XY embryos versus XX-only embryos during a narrow developmental window (8-10 hours after egg laying, AEL ). Here we describe a novel strategy we have conceived to obtain relatively large amounts of XX-only embryos staged at 8-10 h AEL and so to extract few micrograms of polyA+ required to apply the complex technical procedure. The combination of these 3 techniques led to the identification of a Y-linked putative gene, CcGm2, sharing high sequence identity to a paralogous gene, CcGm1, localized either on an autosome or on the X chromosome. We propose that CcGm2 is a first interesting putative Y-linked gene which could play a role in sex determination. The function exterted by this gene should be investigated by novel genetic tools, such as CRISPR-CAS9, which will permit to target only the Y-linked paralogue, avoiding to interfere with the autosomal or X-linked paralogue function.

  11. Subtractive and differential hybridization molecular analyses of Ceratitis capitata XX/XY versus XX embryos to search for male-specific early transcribed genes

    PubMed Central

    2014-01-01

    The agricultural pest Ceratitis capitata, also known as the Mediterranean fruit fly or Medfly, is a fruit crop pest of very high economic relevance in different continents. The strategy to separate Ceratitis males from females (sexing) in mass rearing facilities is a useful step before the sterilization and release of male-only flies in Sterile Insect Technique control programs (SIT). The identification of genes having early embryonic male-specific expression, including Y-linked genes, such as the Maleness factor, could help to design novel and improved methods of sexing in combination with transgenesis, aiming to confer conditional female-specific lethality or female-to-male sexual reversal. We used a combination of Suppression Subtractive Hybrydization (SSH), Mirror Orientation Selection (MOS) and differential screening hybridization (DSH) techniques to approach the problem of isolating corresponding mRNAs expressed in XX/XY embryos versus XX-only embryos during a narrow developmental window (8-10 hours after egg laying, AEL ). Here we describe a novel strategy we have conceived to obtain relatively large amounts of XX-only embryos staged at 8-10 h AEL and so to extract few micrograms of polyA+ required to apply the complex technical procedure. The combination of these 3 techniques led to the identification of a Y-linked putative gene, CcGm2, sharing high sequence identity to a paralogous gene, CcGm1, localized either on an autosome or on the X chromosome. We propose that CcGm2 is a first interesting putative Y-linked gene which could play a role in sex determination. The function exterted by this gene should be investigated by novel genetic tools, such as CRISPR-CAS9, which will permit to target only the Y-linked paralogue, avoiding to interfere with the autosomal or X-linked paralogue function. PMID:25472628

  12. 49 CFR 1242.33 - Other expenses and casualties and insurance (accounts XX-17-99, XX-18-99, XX-19-99, 50-17-00, 50...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (accounts XX-17-99, XX-18-99, XX-19-99, 50-17-00, 50-18-00, and 50-19-00). 1242.33 Section 1242.33....33 Other expenses and casualties and insurance (accounts XX-17-99, XX-18-99, XX-19-99, 50-17-00, 50... separation of administrative—other (account XX-19-06). Operating Expenses—Equipment locomotives ...

  13. The study of the hydrological regime extreme effects of the Caspian Sea during the XX-XXI centuries

    NASA Astrophysics Data System (ADS)

    Yaitskaya, Natalia

    2016-04-01

    The Caspian Sea - the unique largest enclosed inland body of water on Earth. Significant periodic sea level fluctuations are a typical feature of the sea. In the XIX-XX centuries a number of comprehensive studies of the Caspian Sea was carried out. The results are published in the papers, monographs and climatic atlases. But a number of fundamental questions about the features of the hydrological regime of the Caspian Sea is still open: 1. How does the water circulation change during the level variations? 2. What is the effect of heterogeneity of evaporation from the water surface on the formation of the flow field in the conditions of long-term level changes? 3. How does the water salinity regime change depending on the sea level position, water circulation, river flow and different climatic influences? 4. What is the effect of extreme events (multi-hazards) (ice, storms, destruction of the coasts) on coastal infrastructure? In 2016, the project aims to study hydrological regime extreme effects of the Caspian Sea was supported by the Russian Foundation for Basic Research. Within this project all of the above problems will be solved. Geographic information system "Caspian Sea" for the storage and data processing, including a database of primary oceanographic information for the period of instrumental observations (1897-2013), cartographic database (1921-2011) and tools for multidimensional analysis of spatio-temporal information is the basis of the study. The scheme of interconnected hydrodynamic models (Caspian Sea MODel - Ocean Model - Wind wave model) was developed. The important factors are taken into account in the structure of the models: long-term and seasonal dynamics of the sea waves parameters, new long-term values of evaporation from the shallow waters areas of the Caspian Sea, water circulation. Schemes of general seasonal circulation of the Caspian Sea and the Northern Caspian at different positions of the sea level in XX-XXI centuries using

  14. Developing Army Leaders for 21st Century Missions: Teaching Army Leaders Behavioral Science Theories to Educate and Prepare for Full Spectrum Operations

    DTIC Science & Technology

    2002-07-01

    reckoned with and one that is likely to succeed. Leaders who effectively motivate their soldiers inspire , encourage, and guide them toward mission...Virginia 22134-5068 MASTER OF MILITARY STUDIES Developing Army Leaders for 21st Century Missions: Teaching Army Leaders Behavioral Science Theories to...REPORT TYPE Student research paper 3. DATES COVERED (FROM - TO) xx-xx-2001 to xx-xx-2002 4. TITLE AND SUBTITLE Developing Army Leaders for 21st Century

  15. A glance at Spanish embryology and teratology during the XX century through the academic life of Francisco Orts-Llorca (1905-1993).

    PubMed

    Aréchaga, Juan; Jiménez-Collado, Juan; Ruano-Gil, Domingo

    2009-01-01

    Francisco Ort-Llorca (1905-1993) was one of the most outstanding Spanish embryologists of the XX century. He was disciple of Henri Rouvire in Paris (France), Alfred Fischel in Vienna (Austria), Walther Vogt in Munich (Germany) and Pedro Ara in Madrid (Spain). From 1935, he was professor of Human Anatomy at the Faculty of Medicine of Cadiz, belonged then to the University of Seville (accidentally, in the University of Valencia, during the Spanish Civil War from 1936-1939) and, later on, at the Faculty of Medicine of Madrid (Complutense University) from 1954 to 1975. He was internationally recognized in anatomical sciences and stood out for his contributions to descriptive and experimental Embryology and Teratology, particularly in those aspects connected to the normal and pathological development of the heart and visual organs.

  16. 49 CFR 1242.36 - Machinery repair and equipment damaged (accounts XX-26-40 and XX-26-48).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... XX-26-40 and XX-26-48). 1242.36 Section 1242.36 Transportation Other Regulations Relating to... (accounts XX-26-40 and XX-26-48). Separate common expenses according to separation of common expenses in repair and maintenance (account XX-26-41). ...

  17. 49 CFR 1242.20 - Highway grade crossings (accounts XX-17-22 and XX-18-22).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Highway grade crossings (accounts XX-17-22 and XX... RAILROADS 1 Operating Expenses-Way and Structures § 1242.20 Highway grade crossings (accounts XX-17-22 and XX-18-22). Separate running and switching common expenses according to distribution of the running...

  18. Monozygotic twin discordant for Down syndrome: mos 47,XX,+21/46,XX and 46,XX.

    PubMed

    Choi, Sun Ah; Ko, Jung Min; Shin, Choong Ho; Yang, Sei Won; Choi, Jin Sun; Oh, Sun Kyung

    2013-08-01

    Monozygotic twins, developed from a single zygote, are almost identical in clinical phenotype and concordant karyotypes. Monozygotic twins with discordant karyotypes are thought to be quite rare. Here, we report monochorionic-diamniotic twins discordant for Down syndrome. On findings of prenatal ultrasonography, nuchal translucency thickness was different between twins, and suggested that one of the twins was at high risk for having chromosomal abnormalities including Down syndrome. The twins were monochorionic-diamniotic; therefore, chorionic villi sampling of the common placenta was performed. The karyotype of the chorionic villi cells was 46,XX, and pregnancy was maintained. After delivery, dysmorphic clinical features suggesting Down syndrome were found in one of the twins, while the other twin showed a morphologically normal appearance. Karyotypes of peripheral blood leukocytes were repeatedly normal in the dysmorphic twin; however, the karyotype of skin fibroblasts from the dysmorphic twin indicated Down syndrome mosaicism; 47,XX,+21[99]/46,XX[2]. The karyotype of skin fibroblasts from the morphologically normal twin was 46,XX. Monozygosity of the twins was confirmed by a short tandem repeat analysis using 16 polymorphic markers. A mitotic nondisjunction followed by the twinning would explain the discordant karyotypes between monozygotic twins.

  19. 49 CFR 1242.30 - Dismantling retired road property and depreciation (accounts XX-17-39, XX-18-39, XX-19-39, 62-17...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Dismantling retired road property and depreciation....30 Dismantling retired road property and depreciation (accounts XX-17-39, XX-18-39, XX-19-39, 62-17..., switching and other) in proportion to the separation of common repair and maintenance expenses associated...

  20. 49 CFR 1242.84 - Marketing, sales, and public relations and advertising (accounts XX-63-88, XX-63-89 and XX-63-93).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Marketing, sales, and public relations and advertising (accounts XX-63-88, XX-63-89 and XX-63-93). 1242.84 Section 1242.84 Transportation Other... PASSENGER SERVICE FOR RAILROADS 1 Operating Expenses § 1242.84 Marketing, sales, and public relations and...

  1. 49 CFR 1242.17 - Signals and interlockers (accounts XX-17-19 and XX-18-19).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Signals and interlockers (accounts XX-17-19 and XX... RAILROADS 1 Operating Expenses-Way and Structures § 1242.17 Signals and interlockers (accounts XX-17-19 and XX-18-19). Separate common expenses on the basis of the total train-hours in running service, and/or...

  2. 49 CFR 1242.20 - Highway grade crossings (accounts XX-17-22 and XX-18-22).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 9 2011-10-01 2011-10-01 false Highway grade crossings (accounts XX-17-22 and XX-18-22). 1242.20 Section 1242.20 Transportation Other Regulations Relating to Transportation... RAILROADS 1 Operating Expenses-Way and Structures § 1242.20 Highway grade crossings (accounts XX-17-22 and...

  3. 49 CFR 1242.20 - Highway grade crossings (accounts XX-17-22 and XX-18-22).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 9 2012-10-01 2012-10-01 false Highway grade crossings (accounts XX-17-22 and XX-18-22). 1242.20 Section 1242.20 Transportation Other Regulations Relating to Transportation... RAILROADS 1 Operating Expenses-Way and Structures § 1242.20 Highway grade crossings (accounts XX-17-22 and...

  4. 49 CFR 1242.20 - Highway grade crossings (accounts XX-17-22 and XX-18-22).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 9 2014-10-01 2014-10-01 false Highway grade crossings (accounts XX-17-22 and XX-18-22). 1242.20 Section 1242.20 Transportation Other Regulations Relating to Transportation... RAILROADS 1 Operating Expenses-Way and Structures § 1242.20 Highway grade crossings (accounts XX-17-22 and...

  5. 49 CFR 1242.20 - Highway grade crossings (accounts XX-17-22 and XX-18-22).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 9 2013-10-01 2013-10-01 false Highway grade crossings (accounts XX-17-22 and XX-18-22). 1242.20 Section 1242.20 Transportation Other Regulations Relating to Transportation... RAILROADS 1 Operating Expenses-Way and Structures § 1242.20 Highway grade crossings (accounts XX-17-22 and...

  6. Using Title XX to Serve Children and Youth.

    ERIC Educational Resources Information Center

    Twiname, John D.; And Others

    With the passage in early 1975 of the social service amendments to the Social Security Act, referred to as Title XX, a major new opportunity to serve children and youth has emerged. Seizing the opportunity will be largely dependent on the well-prepared presentation of a case for the needs of young people by dedicated advocates in every state.…

  7. 49 CFR 1242.28 - Roadway machines, small tools and supplies, and snow removal (accounts XX-19-36 to XX-19-38...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... snow removal (accounts XX-19-36 to XX-19-38, inclusive). 1242.28 Section 1242.28 Transportation Other... tools and supplies, and snow removal (accounts XX-19-36 to XX-19-38, inclusive). Separate common expenses according to distribution of common expenses listed in § 1242.10, Administration—Track (account XX...

  8. Blockage of progestin physiology disrupts ovarian differentiation in XX Nile tilapia (Oreochromis niloticus)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhou, Linyan; Luo, Feng; Fang, Xuelian

    Previous studies indicated that maturation inducing hormone, 17α, 20β-Dihydroxy-4-pregnen-3-one (DHP), probably through nuclear progestin receptor (Pgr), might be involved in spermatogenesis and oogenesis in fish. To further elucidate DHP actions in teleostean ovarian differentiation, we analyzed the expression of pgr in the ovary of Nile tilapia (Oreochromis niloticus), and performed RU486 (a synthetic Pgr antagonist) treatment in XX fish from 5 days after hatching (dah) to 120dah. Tilapia Pgr was abundantly expressed in the follicular cells surrounding oocytes at 30 and 90dah. Continuous RU486 treatment led to the blockage of oogenesis and masculinization of somatic cells in XX fish. Terminationmore » of RU486 treatment and maintenance in normal condition resulted in testicular differentiation, and estrogen compensation in RU486-treated XX fish successfully restored oogenesis. In RU486-treated XX fish, transcript levels of female dominant genes were significantly reduced, while male-biased genes were evidently augmented. Meanwhile, both germ cell mitotic and meiotic markers were substantially reduced. Consistently, estrogen production levels were significantly declined in RU486-treated XX fish. Taken together, our data further proved that DHP, possibly through Pgr, might be essential in the ovarian differentiation and estrogen production in fish. - Highlights: • DHP plays a critical role in early stage oogenesis of XX tilapia. • Blockage of DHP actions by RU486 treatment led to masculinization and/or sex reversal in XX tilapia. • Both DHP and estrogen are indispensable for ovarian differentiation.« less

  9. Reproducing an Early-20th-Century Wave Machine

    ERIC Educational Resources Information Center

    Daffron, John A.; Greenslade, Thomas B., Jr.

    2016-01-01

    Physics students often have problems understanding waves. Over the years numerous mechanical devices have been devised to show the propagation of both transverse and longitudinal waves (Ref. 1). In this article an updated version of an early-20th-century transverse wave machine is discussed. The original, Fig. 1, is at Creighton University in…

  10. Early Twentieth Century Responses to the Drug Problem.

    ERIC Educational Resources Information Center

    Pfennig, Dennis Joseph

    1991-01-01

    Describes early twentieth-century responses to the drug problem in the United States. Discusses pressure from the media and reformers to control the availability of drugs such as opium and cocaine that were widely available in over-the-counter medications. Focuses on New York State, which took the lead in enacting drug control legislation. (DK)

  11. 49 CFR 1242.56 - Engine crews and train crews (accounts XX-51-56 and XX-51-57).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Engine crews and train crews (accounts XX-51-56 and XX-51-57). 1242.56 Section 1242.56 Transportation Other Regulations Relating to Transportation... RAILROADS 1 Operating Expenses-Transportation § 1242.56 Engine crews and train crews (accounts XX-51-56 and...

  12. Duplication of SOX9 is not a common cause of 46,XX testicular or 46,XX ovotesticular DSD.

    PubMed

    Seeherunvong, Tossaporn; Ukarapong, Supamit; McElreavey, Kenneth; Berkovitz, Gary D; Perera, Erasmo M

    2012-01-01

    Translocation of the SRY gene to the paternal X chromosome is the explanation for testis development in the majority of subjects with 46,XX testicular disorder of sexual development (DSD). However, nearly all subjects with 46,XX ovotesticular DSD and up to one third of subjects with 46,XX testicular DSD lack SRY. SRY-independent expression of SOX9 has been implicated in the etiology of testis development in some individuals. We amplified microsatellite markers in the region of SOX9 from a cohort of 30 subjects with either 46,XX testicular or 46,XX ovotesticular DSD to detect SOX9 duplications. Duplication of the SOX9 region in 17q was not detected in any subject. Duplication in the region of 17q that contains SOX9 is not a common cause of testis development in subjects with SRY-negative 46,XX testicular or ovotesticular DSD.

  13. Early 20th century conceptualization of health promotion.

    PubMed

    Madsen, Wendy

    2017-12-01

    This historical analysis of the term 'health promotion' during the early 20th century in North American journal articles revealed concepts that strongly resonate with those of the 21st century. However, the lineage between these two time periods is not clear, and indeed, this paper supports contentions health promotion has a disrupted history. This paper traces the conceptualizations of health promotion during the 1920s, attempts to operationalize health promotion in the 1930s resulting in a narrowing of the concept to one of health education, and the disappearance of the term from the 1940s. In doing so, it argues a number of factors influenced the changing conceptualization and utilization of health promotion during the first half of the 20th century, many of which continue to present times, including issues around what health promotion is and what it means, ongoing tensions between individual and collective actions, tensions between specific and general causes of health and ill health, and between expert and societal contributions. The paper concludes the lack of clarity around these issues contributed to health promotion disappearing in the mid-20th century and thus resolution of these would be worthwhile for the continuation and development of health promotion as a discipline into the 21st century. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  14. Early 20th-century Arctic warming intensified by Pacific and Atlantic multidecadal variability

    PubMed Central

    Tokinaga, Hiroki; Xie, Shang-Ping; Mukougawa, Hitoshi

    2017-01-01

    With amplified warming and record sea ice loss, the Arctic is the canary of global warming. The historical Arctic warming is poorly understood, limiting our confidence in model projections. Specifically, Arctic surface air temperature increased rapidly over the early 20th century, at rates comparable to those of recent decades despite much weaker greenhouse gas forcing. Here, we show that the concurrent phase shift of Pacific and Atlantic interdecadal variability modes is the major driver for the rapid early 20th-century Arctic warming. Atmospheric model simulations successfully reproduce the early Arctic warming when the interdecadal variability of sea surface temperature (SST) is properly prescribed. The early 20th-century Arctic warming is associated with positive SST anomalies over the tropical and North Atlantic and a Pacific SST pattern reminiscent of the positive phase of the Pacific decadal oscillation. Atmospheric circulation changes are important for the early 20th-century Arctic warming. The equatorial Pacific warming deepens the Aleutian low, advecting warm air into the North American Arctic. The extratropical North Atlantic and North Pacific SST warming strengthens surface westerly winds over northern Eurasia, intensifying the warming there. Coupled ocean–atmosphere simulations support the constructive intensification of Arctic warming by a concurrent, negative-to-positive phase shift of the Pacific and Atlantic interdecadal modes. Our results aid attributing the historical Arctic warming and thereby constrain the amplified warming projected for this important region. PMID:28559341

  15. Early 20th-century Arctic warming intensified by Pacific and Atlantic multidecadal variability

    NASA Astrophysics Data System (ADS)

    Tokinaga, Hiroki; Xie, Shang-Ping; Mukougawa, Hitoshi

    2017-06-01

    With amplified warming and record sea ice loss, the Arctic is the canary of global warming. The historical Arctic warming is poorly understood, limiting our confidence in model projections. Specifically, Arctic surface air temperature increased rapidly over the early 20th century, at rates comparable to those of recent decades despite much weaker greenhouse gas forcing. Here, we show that the concurrent phase shift of Pacific and Atlantic interdecadal variability modes is the major driver for the rapid early 20th-century Arctic warming. Atmospheric model simulations successfully reproduce the early Arctic warming when the interdecadal variability of sea surface temperature (SST) is properly prescribed. The early 20th-century Arctic warming is associated with positive SST anomalies over the tropical and North Atlantic and a Pacific SST pattern reminiscent of the positive phase of the Pacific decadal oscillation. Atmospheric circulation changes are important for the early 20th-century Arctic warming. The equatorial Pacific warming deepens the Aleutian low, advecting warm air into the North American Arctic. The extratropical North Atlantic and North Pacific SST warming strengthens surface westerly winds over northern Eurasia, intensifying the warming there. Coupled ocean-atmosphere simulations support the constructive intensification of Arctic warming by a concurrent, negative-to-positive phase shift of the Pacific and Atlantic interdecadal modes. Our results aid attributing the historical Arctic warming and thereby constrain the amplified warming projected for this important region.

  16. 49 CFR 1242.77 - Administration (account XX-55-01).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Administration (account XX-55-01). 1242.77 Section...-Transportation § 1242.77 Administration (account XX-55-01). Separate common expenses in the same proportion as... systems operations and loss and damage claims processing (accounts XX-55-76, XX-55-77 and XX-55-78). ...

  17. Historical sources on climate and extreme events before XX century in Calabria (Italy)

    NASA Astrophysics Data System (ADS)

    Aurora Pasqua, Angela; Petrucci, Olga

    2014-05-01

    Damaging Hydrogeological Events (DHEs) are defined as the occurrence of destructive phenomena, such as landslides and floods, triggered by extreme rain events. Due to the huge damage that they can cause to people and properties, DHEs are often described in a wide series of historical sources. The historical series of DHEs that affected a study region can supply useful information about the climatic trend of the area. Moreover, it can reveals temporal and spatial increases in vulnerability affecting sectors where urbanization increased throughout the time. On the other side, it can highlight further vulnerability variations occurred throughout the decades and related to specific defensive measures undertaken (or abandoned) in order to prevent damage caused by either landslides or floods. We present the historical series of catastrophic DHEs which affected a Mediterranean region named Calabria that is located in southern Italy. Data presented came from the database named ASICal (the Italian acronym of historically flooded areas in Calabria) that has been built at the beginning of 2000 at CNR-IRPI of Cosenza and that has been continuously updated since then. Currently, this database includes more than 11,000 records about floods and landslides which have been occurred in Calabria since the XVI century. These data came from different information sources as newspapers, archives of regional and national agencies, scientific and technical reports, on-site surveys reports and so on. ASICal is constantly updated. The updating concerns both current DHEs that every years affect the region, and the results of specific historical research that we regularly perform in order to fill data gaps for older epochs. In this work we present the result of a recent survey carried out in some regional public libraries focusing on the early-mid XIX century. The type of data sources available for the regional framework are described and a sketch of the DHEs trend during the last three

  18. Transnational Connections in Early Twentieth-Century Women Teachers' Work

    ERIC Educational Resources Information Center

    Whitehead, Kay

    2012-01-01

    Using a transnational framework, this paper focuses on four graduates of Gipsy Hill Training College (GHTC) for nursery school teachers in London, United Kingdom, in the early to mid-twentieth century. Firstly, I explore GHTC's progressive ideals and highlight ways in which its principal, Lillian de Lissa, encouraged students to "think…

  19. 49 CFR 1242.49 - Equipment damaged (account XX-27-48).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Equipment damaged (account XX-27-48). 1242.49...-Equipment § 1242.49 Equipment damaged (account XX-27-48). Separate common expenses according to distribution... equipment and work and other non-revenue equipment accounts (accounts XX-27-40, XX-27-45, XX-27-46, and XX...

  20. Gender reversal in 46XX congenital virilizing adrenal hyperplasia.

    PubMed

    Sripathi, V; Ahmed, S; Sakati, N; al-Ashwal, A

    1997-05-01

    To review the results of gender reversal in six patients with 46XX congenital virilizing adrenal hyperplasia (CVAH). Fifty-one patients with 46XX CVAH were seen in an 8 year period; 45 were managed by conventional feminizing genitoplasty, but six underwent gender reversal and were managed as males. The clinical decision for gender reversal was made after appropriate counselling and was based primarily on parental choice, this being influenced significantly by a delayed diagnosis in four patients. Surgical management consisted of gonadectomy, excision of Müllerian structures and staged hypospadias repair/ chordee correction in four patients, and circumcision in two completely masculinized children. All six boys are well adjusted to their gender of rearing, with ages ranging from 3 years to 16.5 years (mean 8.5) at the time of review. Two children have normal penises and four have a satisfactory result after two-stage repair of hypospadias/chordee. Most patients with 46XX CVAH are preferably raised as females and require a feminizing genitoplasty. However, the clinical decision may be influenced by many factors, including delay in diagnosis, social bias and the premium on male rearing in certain communities. When male rearing is chosen, early gonadectomy and excision of Müllerian structures, together with staged hypospadias repair, gives satisfactory results.

  1. Learning Early Twentieth-Century History through First-Person Interviews

    ERIC Educational Resources Information Center

    Lark, Lisa A.

    2007-01-01

    For many of the students in the author's American history class, early twentieth-century American history seems far removed from their daily lives. Being first and second-generation American citizens, many of the students do not have the luxury of hearing grandparents and great-grandparents telling stories about FDR and Henry Ford. More…

  2. Signatures and Popular Literacy in Early Seventeenth-Century Japan

    ERIC Educational Resources Information Center

    Rubinger, Richard

    2006-01-01

    My paper looks at "signatures" in the form of "ciphers" (kao) and other personal marks made on population registers, town rules, and apostasy oaths in the early seventeenth century to provide some empirical evidence of very high literacy among village leaders. The essay also argues, using the same data, that literacy had…

  3. Regionalism and Development in Early Nineteenth Century Spanish America.

    ERIC Educational Resources Information Center

    Friedman, Douglas

    An understanding of regionalism in early 19th century Spanish America is crucial to any understanding of this region's economic development. Regionalism became the barrier to the kind of integrated national economy that some writers claim could have been implemented had it not been for the imposition of dependency by external forces. This…

  4. 2. Copy of early 20th century photograph showing Euclid Avenue ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Copy of early 20th century photograph showing Euclid Avenue facade, looking norh. Photograph owned by H.D. Koblitz. - F. B. Stearns Company, Euclid & Lakeview Avenues, Cleveland, Cuyahoga County, OH

  5. 12. Copy of early 20th century photograph showing facade, looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Copy of early 20th century photograph showing facade, looking west. Photograph owned by Parker-Hannifin Corporation. - Cleveland-Chandler Motors Corporation, 300 East 131st Street, Cleveland, Cuyahoga County, OH

  6. Hurst exponent of very long birth time series in XX century Romania. Social and religious aspects

    NASA Astrophysics Data System (ADS)

    Rotundo, G.; Ausloos, M.; Herteliu, C.; Ileanu, B.

    2015-07-01

    The Hurst exponent of very long birth time series in Romania has been extracted from official daily records, i.e. over 97 years between 1905 and 2001 included. The series result from distinguishing between families located in urban (U) or rural (R) areas, and belonging (Ox) or not (NOx) to the orthodox religion. Four time series combining both criteria, (U,R) and (Ox, NOx), are also examined. A statistical information is given on these sub-populations measuring their XX-th century state as a snapshot. However, the main goal is to investigate whether the "daily" production of babies is purely noisy or is fluctuating according to some non trivial fractional Brownian motion, - in the four types of populations, characterized by either their habitat or their religious attitude, yet living within the same political regime. One of the goals was also to find whether combined criteria implied a different behavior. Moreover, we wish to observe whether some seasonal periodicity exists. The detrended fluctuation analysis technique is used for finding the fractal correlation dimension of such (9) signals. It has been first necessary, due to two periodic tendencies, to define the range regime in which the Hurst exponent is meaningfully defined. It results that the birth of babies in all cases is a very strongly persistent signal. It is found that the signal fractal correlation dimension is weaker (i) for NOx than for Ox, and (ii) or U with respect to R. Moreover, it is observed that the combination of U or R with NOx or OX enhances the UNOx, UOx, and ROx fluctuations, but smoothens the RNOx signal, thereby suggesting a stronger conditioning on religiosity rituals or rules.

  7. Early 20th Century Arctic Warming Intensified by Pacific and Atlantic Multidecadal Variability

    NASA Astrophysics Data System (ADS)

    Tokinaga, H.; Xie, S. P.; Mukougawa, H.

    2017-12-01

    We investigate the influence of Pacific and Atlantic multidecadal variability on the Arctic temperature, with a particular focus on the early 20th century Arctic warming. Arctic surface air temperature increased rapidly over the early 20th century, at rates comparable to those of recent decades despite much weaker greenhouse gas forcing than at present. We find that the concurrent phase shift of Pacific and Atlantic multidecadal variability is the major driver for the early 20th century Arctic warming. Atmospheric model simulations reproduce the early Arctic warming when the interdecadal variability of sea surface temperature (SST) is properly prescribed. The early Arctic warming is associated with the cold-to-warm phase shifts of Atlantic and Pacific multidecadal variability modes, a SST pattern reminiscent of the positive phase of the Pacific decadal and Atlantic multidecadal oscillations. The extratropical North Atlantic and North Pacific SST warming strengthens surface westerly winds over northern Eurasia, intensifying the warming there. The equatorial Pacific warming deepens the Aleutian low, advecting warm air to the North American Arctic. Coupled ocean-atmosphere simulations support the constructive intensification of Arctic warming by a concurrent, cold-to-warm phase shift of the Pacific and Atlantic multidecadal variability. Our results aid attributing the historical Arctic warming and thereby constrain the amplified warming projected for this important region.

  8. 49 CFR 1242.34 - Administration (account XX-26-01).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Administration (account XX-26-01). 1242.34 Section...-Equipment § 1242.34 Administration (account XX-26-01). Separate common expenses according to distribution of common expenses in the following accounts: Repair and Maintenance (XX-26-41) Machinery Repair (XX-26-40...

  9. Premature Infant Care in the Early 20th Century.

    PubMed

    Prescott, Stephanie; Hehman, Michelle C

    The complex early history of infant incubators provides insight into challenges faced by medical professionals as they promoted care for premature infants in the early 20th century. Despite their absence from the narrative to date, nurses played vital roles in the development of neonatal care. Working in many different settings, from incubator-baby shows to the first hospital unit designed specifically for premature infants, nurses administered quality care and promoted advanced treatment for these newborns. Copyright © 2017 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses. Published by Elsevier Inc. All rights reserved.

  10. 3. Copy of early 20th century photograph of Assembly Bldg., ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Copy of early 20th century photograph of Assembly Bldg., interior. Photograph owned by: The Crawford Auto-Aviation Museum, 10825 East Blvd., Cleveland, Ohio. - Winton Motor Carriage Company, Berea Road & Madison Avenue, Cleveland, Cuyahoga County, OH

  11. No evidence for an early seventeenth-century Indian sighting of Kepler's supernova (SN1604)

    NASA Astrophysics Data System (ADS)

    van Gent, R. H.

    2013-03-01

    In a recent paper in this journal, Sule et al. (2011) argued that an early 17th-century Indian mural of the constellation Sagittarius with a dragon-headed tail indicated that the bright supernova of 1604 was also sighted by Indian astronomers. In this paper it will be shown that this identification is based on a misunderstanding of traditional Islamic astrological iconography and that the claim that the mural represents an early 17th-century Indian sighting of the supernova of 1604 has to be rejected.

  12. 49 CFR 1242.12 - Administration-signals (account XX-19-04).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Administration-signals (account XX-19-04). 1242.12... Structures § 1242.12 Administration—signals (account XX-19-04). Separate common administration—signals... (XX-17-19) Switching (XX-18-19) ...

  13. 2. Copy of early 20th Century photograph showing interior of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Copy of early 20th Century photograph showing interior of Assembly Bldg. Photograph owned by the Crawford Auto-Aviation Museum 10825 East Blvd., Cleveland, Ohio. - Winton Motor Carriage Company, Berea Road & Madison Avenue, Cleveland, Cuyahoga County, OH

  14. Attempt to rescue sex-reversal by transgenic expression of the PISRT1 gene in XX PIS-/- goats.

    PubMed

    Boulanger, L; Kocer, A; Daniel, N; Pannetier, M; Chesné, P; Heyman, Y; Renault, L; Mandon-Pépin, B; Chavatte-Palmer, P; Vignon, X; Vilotte, J-L; Cotinot, C; Renard, J-P; Pailhoux, E

    2008-01-01

    The Polled Intersex Syndrome (PIS mutation) in goats leads to an absence of horn and to an early sex-reversal of the XX gonads. This mutation is a deletion of an 11.7-kb DNA fragment showing a tissue-specific regulatory activity. Indeed, in XX PIS(-/-) gonads the deletion of PIS leads to the transcriptional extinction of at least 3 neighboring genes, FOXL2, PFOXic and PISRT1. Among them, only FOXL2 is a 'classical' gene, encoding a highly conserved transcription factor. On the other hand, knock-out of Foxl2 in mice results in an early blocking of follicle formation without sex-reversal. This phenotype discrepancy leads to two hypotheses, either FOXL2 is responsible for XX sex-reversal in goat assuming distinct functions of its protein during ovarian differentiation in different mammals, or other PIS-regulated genes are involved. To assess the second possibility, PISRT1 expression was constitutively restored in XX PIS(-/-) gonads. Six transgenic fetuses were obtained by nuclear transfer and studied at 2 developmental stages, 41 and 46 days post-reconstruction. The gonads of these fetuses appear phenotypically identical to those of cloned non-transgenic controls. Conclusively, this result argues for FOXL2 being responsible for the PIS gonad-associated phenotype. Its invalidation in goat will help to better understand this complex syndrome. Copyright 2008 S. Karger AG, Basel.

  15. 11. Copy of early 20th century photograph, an aerial view, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Copy of early 20th century photograph, an aerial view, showing the plant from the south looking north. Photo owned by the Parker- Hannifin Corporation. - Cleveland-Chandler Motors Corporation, 300 East 131st Street, Cleveland, Cuyahoga County, OH

  16. 1. Copy of early 20th Century lithograph looking north showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Copy of early 20th Century lithograph looking north showing aerial view of company. Rendering owned by the Crawford Auto- aviation Museum, 10825 East Blvd, Cleveland, Ohio. - Winton Motor Carriage Company, Berea Road & Madison Avenue, Cleveland, Cuyahoga County, OH

  17. 2. Photocopy of early 20th century drawing, looking south from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of early 20th century drawing, looking south from the air. Drawing owned by the Crawford Auto-Aviation Museum, 10825 East Blvd., Cleveland, Ohio. - Peerless Motor Car Company, East Ninety-third Street & Quincy Avenue, Cleveland, Cuyahoga County, OH

  18. 1. Photocopy of early 20th century rendering showing aerial veiw, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Photocopy of early 20th century rendering showing aerial veiw, looking south. Rendering owned by the Crawford Auto-Aviation Museum, 10825 East Blvd., Cleveland, Ohio. - Peerless Motor Car Company, East Ninety-third Street & Quincy Avenue, Cleveland, Cuyahoga County, OH

  19. Roadmap Through Title XX. Financing Services for Children Through Title XX and Other Programs: Manual 5.

    ERIC Educational Resources Information Center

    Copeland, William C.; Iversen, Iver A.

    This manual, part of a Hecht Institute four-manual series entitled Financing Children's Services Through Title XX and Related Programs, teaches what Title XX regulations are, what they mean, and what actions and procedures are commanded by them. The first section covers the necessity of rule systems, the characteristics of a good rule system and…

  20. 2. Photocopy of early 20th century photo, showing the Euclid ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of early 20th century photo, showing the Euclid Avenue facade of the branch assembly building. Photograph owned by the Cleveland Public Library. - Ford Motor Company, Cleveland Branch Assembly Plant, Euclid Avenue & East 116th Street, Cleveland, Cuyahoga County, OH

  1. 1. Photocpy of early 20th century photograph, looking east, of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Photocpy of early 20th century photograph, looking east, of east facade of assembly building on Euclid Ave. Photo owned by the Cleveland Public Library. - Ford Motor Company, Cleveland Branch Assembly Plant, Euclid Avenue & East 116th Street, Cleveland, Cuyahoga County, OH

  2. 49 CFR 1242.18 - Communication systems (account XX-19-20).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Communication systems (account XX-19-20). 1242.18... Structures § 1242.18 Communication systems (account XX-19-20). Separate common expenses on the basis of the... (accounts XX-19-02 to XX-19-04, inclusive) Equipment—Administration—Locomotives and Other Equipment...

  3. American Influence on Chinese Physics Study in the Early Twentieth Century

    NASA Astrophysics Data System (ADS)

    Hu, Danian

    2016-01-01

    To save China from the perils she faced in the early twentieth century, the majority of the Chinese seemed to agree that it was necessary to strengthen the country by developing shiye or industry and commerce. For this purpose, they overhauled China's education system and sent a large number of students to study overseas. Many of them enrolled in American colleges, sponsored either by governmental grants or by private funds. As American physics advanced rapidly during the early twentieth century, Chinese physicists studying in top US institutions received first-class professional training. They later went on to become a main driving force in Chinese physics development. The study-in-America programs were apparently more successful than other study-overseas programs. Among other factors, the historical lessons learned from the aborted Chinese Educational Mission in the 1870s, the prevalent and long-time presence of American mission schools in China, and stable public and private funding contributed to their success. American-trained Chinese physicists not only advanced physics study in China but also played leading roles in the development of Chinese science and technology during the twentieth century. This fertile and far-reaching American influence has been embedded in all their accomplishments.

  4. 4. Photocopy of early 20th century photo of the bridge. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Photocopy of early 20th century photo of the bridge. Donated to HAER for its collection at the Library of Congress; donation courtesy of the Erie Railroad Company. - Erie Railway, Moodna Creek Viaduct, Moodna Creek, Orrs Mill Road, Salisbury Mills, Orange County, NY

  5. 49 CFR 1242.47 - Machinery (account XX-27-40).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Machinery (account XX-27-40). 1242.47 Section 1242...-Equipment § 1242.47 Machinery (account XX-27-40). Separate common expenses on the basis of the freight/passenger separation of administration (account XX-27-01). ...

  6. 49 CFR 1242.43 - Administration (account XX-27-01).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Administration (account XX-27-01). 1242.43 Section...-Equipment § 1242.43 Administration (account XX-27-01). Separate common expenses according to freight/passenger separation of the following accounts: Passenger and Other Revenue Equipment (XX-27-45) Work and...

  7. Inherited XX sex reversal originating from wild medaka populations.

    PubMed

    Shinomiya, A; Otake, H; Hamaguchi, S; Sakaizumi, M

    2010-11-01

    The teleost fish, medaka (Oryzias latipes), has an XX/XY sex-determining mechanism. A Y-linked DM domain gene, DMY, has been isolated by positional cloning as the sex-determining gene in this species. Previously, we conducted a field survey of genotypic sex and found that approximately 1% of wild medaka are sex-reversed (XX males and XY females). Here, we performed genetic analyses of nine spontaneous XX sex-reversed males to elucidate its genetic basis. In all cases, the F(1) progeny were all females, whereas XX males reappeared in the backcross (BC) progeny, suggesting that XX sex reversal is a recessive trait. Although the incidences of sex reversal in the BC progeny were mostly low, 40% were males derived from one XX male. We performed linkage analysis using 55 BC males and located a single major factor, sda-1 (sex-determining autosomal factor-1), controlling sex reversal in an autosomal linkage group. Thus, genes involved in the sex-determining pathway can be isolated from spontaneous mutants in wild populations.

  8. 45,X/47,XXX/47,XX, del(Y)(p?)/46,XX mosaicism causing true hermaphroditism.

    PubMed

    Nieto, Karem; Peña, Rocío; Palma, Icela; Dorantes, Luis M; Eraña, Luis; Alvarez, Rebeca; García-Cavazos, Ricardo; Kofman-Alfaro, Susana; Queipo, Gloria

    2004-10-15

    Sex differentiation in humans depends on the presence of the Y-linked gene SRY, which is activated in the pre-Sertoli cells of the developing gonadal primordium to trigger testicular differentiation. Occasionally testicular formation can take place in subjects lacking a Y chromosome resulting in a 46,XX sex reversal condition. True hermaphroditism (TH) is a rare form of intersexuality characterized by the presence of testicular and ovarian tissue in the same individual. Genetic heterogeneity has been proposed as a cause of dual gonadal development in some cases and recently, hidden mosaicism was reported to cause TH in some 46,XX SRY negative patients. Here we report a TH case in which hidden mosaicism for the Y and X chromosome was detected by PCR and FISH in peripheral blood and gonadal tissue, supporting the fact that mosaicism may cause TH and that molecular analysis of gonadal tissue should be performed in all 46,XX cases.

  9. The reddening and variability of XX Ophiuchi

    NASA Technical Reports Server (NTRS)

    Evans, A.; Albinson, J. S.; Barrett, P.; Davies, J. K.; Goldsmith, M. J.; Hutchinson, M. G.; Maddison, R. C.

    1993-01-01

    We present polarization data on the XX Oph system which suggest that the interstellar extinction to this object has been overestimated in the past: our data imply A(V) = 1.6 mag. Our photometry and infrared spectroscopy suggest a spectral class of M7III for the late component, and a BOV companion that ionizes the wind of the cool component. XX Oph seems more like a Zeta Aur/VV Cep system than a 'symbiotic object'. The photometric variability of XX Oph seems to have a number of causes, ranging from shell-type variability in the U band to variations in the M component in the infrared.

  10. Industrial Characteristics and Employment of Older Manufacturing Workers in the Early-Twentieth-Century United States

    PubMed Central

    Lee, Chulhee

    2015-01-01

    This study explores how industry-specific technological, organizational, and managerial features affected the employment of old male manufacturing workers in the early twentieth-century United States. Industrial characteristics favorably related to the employment of old industrial workers include high labor productivity, less capital- and material-intensive production, short workdays, low intensity of work, high job flexibility, and formalized employment relationship. Results show that aged industrial workers were heavily concentrated in “unfavorable” industries, suggesting that the contemporary argument of “industrial scrap heap” was applicable for most of the manufacturing workers in the early twentieth century United States. PMID:26989273

  11. 49 CFR 1242.14 - Administration-other (account XX-19-06).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Administration-other (account XX-19-06). 1242.14... Structures § 1242.14 Administration—other (account XX-19-06). Separate common administration—other expenses... accounts are separated between freight and passenger services: Administration: Track (XX-19-02) Bridges and...

  12. Cherokee Practice, Missionary Intentions: Literacy Learning among Early Nineteenth-Century Cherokee Women

    ERIC Educational Resources Information Center

    Moulder, M. Amanda

    2011-01-01

    This article discusses how archival documents reveal early nineteenth-century Cherokee purposes for English-language literacy. In spite of Euro-American efforts to depoliticize Cherokee women's roles, Cherokee female students adapted the literacy tools of an outsider patriarchal society to retain public, political power. Their writing served…

  13. 49 CFR 1242.13 - Administration-communica- tions (account XX-19-05).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Administration-communica- tions (account XX-19-05... Structures § 1242.13 Administration—communica- tions (account XX-19-05). Separate common administration... (XX-19-20) ...

  14. 49 CFR 1242.25 - Locomotive servicing facilities (account XX-19-27).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OPERATING EXPENSES BETWEEN FREIGHT SERVICE AND PASSENGER SERVICE FOR RAILROADS 1 Operating Expenses-Way and...) Electric Power Purchased or Produced for Motive Power (XX-51-68 and XX-52-68) Servicing Locomotives (XX-51...

  15. The acceleration of the masculine in early-twentieth-century Berlin.

    PubMed

    Prickett, David James

    2012-01-01

    In early-twentieth-century Berlin, agents of speed and industrialisation, such as the railway, contributed to the seemingly unbridled velocity of urban life. Doctors and cultural critics took an ambivalent stance toward the impact of speed and technology on the human body. Critics argued that these factors, in conjunction with sexual excess and prostitution, accelerated the sexual maturation of young men, thereby endangering ‘healthy’ male sexuality. This comparison of Hans Ostwald's socio-literary study Dunkle Winkel in Berlin (1904) with Georg Buschan's sexual education primer Vom Jüngling zum Mann (1911) queries the extent to which speed shaped the understanding of ‘the masculine’ in pre-World-War-I Germany. The essay thus examines Ostwald's and Buschan's arguments and postulates that speed in the city (Berlin) can be seen as a feminised, sexualised force that determined sex in the city. According to this reading, the homosexual urban dandy resisted the accelerated modernist urban tempo, whereas the heterosexual man and hegemonic, heteronormative masculinity yielded to speed. ‘“Das Verhältnis”’ became a fleeting, momentary alternative to stable marital relationships, which in turn contributed to the general ‘crisis’ of – and in– masculinity in early-twentieth-century Berlin.

  16. 49 CFR 1242.16 - Road property damaged-other (account XX-19-48).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Road property damaged-other (account XX-19-48... Structures § 1242.16 Road property damaged—other (account XX-19-48). Separate common expenses in proportion... accounts: Road Property Damaged—Running (XX-17-48) Road Property Damaged—Switching (XX-18-48) ...

  17. 49 CFR 1242.66 - Administration (account XX-52-01).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OPERATING EXPENSES BETWEEN FREIGHT SERVICE AND PASSENGER SERVICE FOR RAILROADS 1 Operating Expenses...) Locomotive Fuel (XX-52-67) Servicing Locomotives (XX-52-69) Electric Power Purchased/Produced for Motive...

  18. 49 CFR 1242.55 - Administration (account XX-51-01).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OPERATING EXPENSES BETWEEN FREIGHT SERVICE AND PASSENGER SERVICE FOR RAILROADS 1 Operating Expenses...) Electric Power Purchased/Produced for Motive Power (XX-51-68) Servicing Locomotives (XX-51-69) Clearing...

  19. Costs of landslides and floods in XX Century in a Calabrian town starting from the data stored in the Historical Archive of IRPI (Cosenza)

    NASA Astrophysics Data System (ADS)

    Giampa', Vincenzo; Pasqua, A. Aurora; Petrucci, Olga

    2015-04-01

    The paper firstly presents the historical archive of Cosenza IRPI Section and the historical database that has been built basing on the data contained in it. Then, an application of these data to Catanzaro, the town that is the administrative center of Calabria region (Southern Italy), is presented. The gathering of historical data on past floods and landslides in Cosenza IRPI Section has been started since 1996, and it is still in progress. In 2005, some donations coming from regional and municipal Public Works offices greatly increased the documental corpus, and required a more incisive classification and management that led us to organize the documents in a real historical archive. Documents were sorted according to municipalities they concerned. In this way, for each of the 409 municipalities of Calabria a set of documents, maps and images was available. Collected documents mainly concern damage caused by the occurrence, since XIX century, of phenomena as floods, flash floods and landslides triggered by extreme meteorological events, or even damage caused by strong earthquakes. At the beginning of 2014, the central office of IRPI (Perugia) funded a project aiming to the digitalization of the archive and the subsequent publication of it on a web-platform. In this paper, the procedure adopted to build the archive and implement the database is described. Then, the elaboration of the historical series of data on Catanzaro town, which has been frequently damaged by rainfall-induced landslides and floods, is also presented. Basing on the documents coming from the archive of Ministry Public Works and stored in our Historical Archive, an assessment of costs related to damage that during XX century affected the houses of this town has been performed. The research pointed out the types of most damaging phenomena, the municipal sectors most frequently damaged, and the evolution of damaged areas throughout the years according to the increasing urbanization.

  20. The Not-so-Dark Ages: ecology for human growth in medieval and early twentieth century Portugal as inferred from skeletal growth profiles.

    PubMed

    Cardoso, Hugo F V; Garcia, Susana

    2009-02-01

    This study attempts to address the issue of relative living standards in Portuguese medieval and early 20th century periods. Since the growth of children provides a good measure of environmental quality for the overall population, the skeletal growth profiles of medieval Leiria and early 20th century Lisbon were compared. Results show that growth in femur length of medieval children did not differ significantly from that of early 20th century children, but after puberty medieval adolescents seem to have recovered, as they have significantly longer femora as adults. This is suggestive of greater potential for catch-up growth in medieval adolescents. We suggest that this results from distinct child labor practices, which impact differentially on the growth of Leiria and Lisbon adolescents. Work for medieval children and adolescents were related to family activities, and care and attention were provided by family members. Conversely, in early 20th century Lisbon children were more often sent to factories at around 12 years of age as an extra source of family income, where they were exploited for their labor. Since medieval and early 20th century children were stunted at an early age, greater potential for catch-up growth in medieval adolescents results from exhausting work being added to modern adolescent's burdens of disease and poor diet, when they entered the labor market. Although early 20th century Lisbon did not differ in overall unfavorable living conditions from medieval Leiria, after puberty different child labor practices may have placed modern adolescents at greater risk of undernutrition and poor growth. 2008 Wiley-Liss, Inc.

  1. 21st century early mission concepts for Mars delivery and earth return

    NASA Technical Reports Server (NTRS)

    Cruz, Manuel I.; Ilgen, Marc R.

    1990-01-01

    In the 21st century, the early missions to Mars will entail unmanned Rover and Sample Return reconnaissance missions to be followed by manned exploration missions. High performance leverage technologies will be required to reach Mars and return to earth. This paper describes the mission concepts currently identified for these early Mars missions. These concepts include requirements and capabilities for Mars and earth aerocapture, Mars surface operations and ascent, and Mars and earth rendezvous. Although the focus is on the unmanned missions, synergism with the manned missions is also discussed.

  2. Future dryness in the southwest US and the hydrology of the early 21st century drought

    PubMed Central

    Cayan, Daniel R.; Das, Tapash; Pierce, David W.; Barnett, Tim P.; Tyree, Mary; Gershunov, Alexander

    2010-01-01

    Recently the Southwest has experienced a spate of dryness, which presents a challenge to the sustainability of current water use by human and natural systems in the region. In the Colorado River Basin, the early 21st century drought has been the most extreme in over a century of Colorado River flows, and might occur in any given century with probability of only 60%. However, hydrological model runs from downscaled Intergovernmental Panel on Climate Change Fourth Assessment climate change simulations suggest that the region is likely to become drier and experience more severe droughts than this. In the latter half of the 21st century the models produced considerably greater drought activity, particularly in the Colorado River Basin, as judged from soil moisture anomalies and other hydrological measures. As in the historical record, most of the simulated extreme droughts build up and persist over many years. Durations of depleted soil moisture over the historical record ranged from 4 to 10 years, but in the 21st century simulations, some of the dry events persisted for 12 years or more. Summers during the observed early 21st century drought were remarkably warm, a feature also evident in many simulated droughts of the 21st century. These severe future droughts are aggravated by enhanced, globally warmed temperatures that reduce spring snowpack and late spring and summer soil moisture. As the climate continues to warm and soil moisture deficits accumulate beyond historical levels, the model simulations suggest that sustaining water supplies in parts of the Southwest will be a challenge. PMID:21149687

  3. Future dryness in the Southwest US and the hydrology of the early 21st century drought

    USGS Publications Warehouse

    Cayan, D.R.; Das, T.; Pierce, D.W.; Barnett, T.P.; Tyree, Mary; Gershunova, A.

    2010-01-01

    Recently the Southwest has experienced a spate of dryness, which presents a challenge to the sustainability of current water use by human and natural systems in the region. In the Colorado River Basin, the early 21st century drought has been the most extreme in over a century of Colorado River flows, and might occur in any given century with probability of only 60%. However, hydrological model runs from downscaled Intergovernmental Panel on Climate Change Fourth Assessment climate change simulations suggest that the region is likely to become drier and experience more severe droughts than this. In the latter half of the 21st century the models produced considerably greater drought activity, particularly in the Colorado River Basin, as judged from soil moisture anomalies and other hydrological measures. As in the historical record, most of the simulated extreme droughts build up and persist over many years. Durations of depleted soil moisture over the historical record ranged from 4 to 10 years, but in the 21st century simulations, some of the dry events persisted for 12 years or more. Summers during the observed early 21st century drought were remarkably warm, a feature also evident in many simulated droughts of the 21st century. These severe future droughts are aggravated by enhanced, globally warmed temperatures that reduce spring snowpack and late spring and summer soil moisture. As the climate continues to warm and soil moisture deficits accumulate beyond historical levels, the model simulations suggest that sustaining water supplies in parts of the Southwest will be a challenge.

  4. 49 CFR 1242.22 - Shop buildings-locomotives (account XX-19-24).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Shop buildings-locomotives (account XX-19-24... Structures § 1242.22 Shop buildings—locomotives (account XX-19-24). Separate common expenses according to distribution of common expenses in the following accounts: Machinery Repair (XX-26-40) Locomotive—Repair and...

  5. 49 CFR 1242.79 - Communication systems operations (account XX-55-77).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Communication systems operations (account XX-55-77...-Transportation § 1242.79 Communication systems operations (account XX-55-77). Separate common expenses on bases of the percentages calculated for the separation of Communication Systems (account XX-19-20), § 1242...

  6. 49 CFR 1242.28 - Roadway machines, small tools and supplies, and snow removal (accounts XX-19-36 to XX-19-38...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 9 2011-10-01 2011-10-01 false Roadway machines, small tools and supplies, and snow removal (accounts XX-19-36 to XX-19-38, inclusive). 1242.28 Section 1242.28 Transportation Other... PASSENGER SERVICE FOR RAILROADS 1 Operating Expenses-Way and Structures § 1242.28 Roadway machines, small...

  7. Intertransitions between Islam and Eastern Orthodoxy in Kazakhstan (Nineteenth-Early Twentieth Centuries)

    ERIC Educational Resources Information Center

    Sadvokasova, Zakish T.; Orazbayeva, Altynay I.

    2016-01-01

    The purpose of this paper is to review the historical facts related to conversion of indigenous people of the Kazakh steppe from Islam to Christianity and the conversion of the Russian migrants from Orthodoxy to Islam in Kazakhstan in the nineteenth-early twentieth century. The study deals with the laws that were detrimental to Islam and reforms…

  8. Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells.

    PubMed

    Shishido, Yurina; Baba, Takashi; Sato, Tetsuya; Shima, Yuichi; Miyabayashi, Kanako; Inoue, Miki; Akiyama, Haruhiko; Kimura, Hiroshi; Kanai, Yoshiakira; Ishihara, Yasuhiro; Haraguchi, Shogo; Miyazaki, Akira; Rozman, Damjana; Yamazaki, Takeshi; Choi, Man-Ho; Ohkawa, Yasuyuki; Suyama, Mikita; Morohashi, Ken-Ichirou

    2017-02-02

    SRY, a sex-determining gene, induces testis development in chromosomally female (XX) individuals. However, mouse XX Sertoli cells carrying Sry (XX/Sry Sertoli cells) are incapable of fully supporting germ cell development, even when the karyotype of the germ cells is XY. While it has therefore been assumed that XX/Sry Sertoli cells are not functionally equivalent to XY Sertoli cells, it has remained unclear which specific functions are affected. To elucidate the functional difference, we compared the gene expression of XY and XX/Sry Sertoli cells. Lactate and cholesterol metabolisms, essential for nursing the developing germ cells, were down-regulated in XX/Sry cells, which appears to be caused at least in part by the differential expression of histone modification enzymes SMCX/SMCY (H3K4me3 demethylase) and UTX/UTY (H3K27me3 demethylase) encoded by the sex chromosomes. We suggest that down-regulation of lactate and cholesterol metabolism that may be due to altered epigenetic modification affects the nursing functions of XX/Sry Sertoli cells.

  9. Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells

    PubMed Central

    Shishido, Yurina; Baba, Takashi; Sato, Tetsuya; Shima, Yuichi; Miyabayashi, Kanako; Inoue, Miki; Akiyama, Haruhiko; Kimura, Hiroshi; Kanai, Yoshiakira; Ishihara, Yasuhiro; Haraguchi, Shogo; Miyazaki, Akira; Rozman, Damjana; Yamazaki, Takeshi; Choi, Man-Ho; Ohkawa, Yasuyuki; Suyama, Mikita; Morohashi, Ken-ichirou

    2017-01-01

    SRY, a sex-determining gene, induces testis development in chromosomally female (XX) individuals. However, mouse XX Sertoli cells carrying Sry (XX/Sry Sertoli cells) are incapable of fully supporting germ cell development, even when the karyotype of the germ cells is XY. While it has therefore been assumed that XX/Sry Sertoli cells are not functionally equivalent to XY Sertoli cells, it has remained unclear which specific functions are affected. To elucidate the functional difference, we compared the gene expression of XY and XX/Sry Sertoli cells. Lactate and cholesterol metabolisms, essential for nursing the developing germ cells, were down-regulated in XX/Sry cells, which appears to be caused at least in part by the differential expression of histone modification enzymes SMCX/SMCY (H3K4me3 demethylase) and UTX/UTY (H3K27me3 demethylase) encoded by the sex chromosomes. We suggest that down-regulation of lactate and cholesterol metabolism that may be due to altered epigenetic modification affects the nursing functions of XX/Sry Sertoli cells. PMID:28150810

  10. XX males SRY negative: a confirmed cause of infertility.

    PubMed

    Vetro, Annalisa; Ciccone, Roberto; Giorda, Roberto; Patricelli, Maria Grazia; Della Mina, Erika; Forlino, Antonella; Zuffardi, Orsetta

    2011-10-01

    SOX9 is a widely expressed transcription factor playing several relevant functions during development and essential for testes differentiation. It is considered to be the direct target gene of the protein encoded by SRY and its overexpression in an XX murine gonad can lead to male development in the absence of Sry. Recently, a family was reported with a 178 kb duplication in the gene desert region ending about 500 kb upstream of SOX9 in which 46,XY duplicated persons were completely normal and fertile whereas the 46,XX ones were males who came to clinical attention because of infertility. We report a family with two azoospermic brothers, both 46,XX, SRY negative, having a 96 kb triplication 500 kb upstream of SOX9. Both subjects have been analyzed trough oligonucleotide array-CGH and the triplication was confirmed and characterised through qPCR, defining the minimal region of amplification upstream of SOX9 associated with 46,XX infertile males, SRY negative. Our results confirm that even in absence of SRY, complete male differentiation may occur, possibly driven by overexpression of SOX9 in the gonadal ridge, as a consequence of the amplification of a gene desert region. We hypothesize that this region contains gonadal specific long-range regulation elements whose alteration may impair the normal sex development. Our data show that normal XX males, with alteration in copy number or, possibly, in the critical sequence upstream to SOX9 are a new category of infertility inherited in a dominant way with expression limited to the XX background.

  11. Title XX and CETA. A Coordination Guide for Title XX Administrators.

    ERIC Educational Resources Information Center

    Urban Management Consultants of San Francisco, Inc., CA.

    Written for the social service (Title XX) administrator at the State or sub-State level, this guide is intended to serve four major purposes: (1) Provide selected insights into what the Comprehensive Employment and Training Act (CETA) is and how it works; (2) point out potential areas for coordination which, from study or field experience, hold…

  12. 78 FR 15406 - Proposed Collection; Comment Request for Revenue Procedure 2013-XX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-11

    ... Revenue Procedure 2013- XX AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request... comments concerning Revenue Procedure 2013-XX, Disaster Relief. DATES: Written comments should be received... . SUPPLEMENTARY INFORMATION: Title: Disaster Relief. OMB Number: 1545-2237. Form Number: Rev. Proc. 2013-XX...

  13. Severe XIST hypomethylation clearly distinguishes (SRY+) 46,XX-maleness from Klinefelter syndrome.

    PubMed

    Poplinski, Andreas; Wieacker, Peter; Kliesch, Sabine; Gromoll, Jörg

    2010-01-01

    46,XX-maleness affects 1 in 20 000 live male newborns resulting in infertility and hypergonadotrophic hypogonadism. Although the phenotypes of XX-males have been well described, the molecular nature of the X chromosomes remains elusive. We assessed the X inactivation status by DNA methylation analysis of four informative loci and compared those to Klinefelter syndrome (KS) and Turner syndrome. Patient cohort consisted of ten sex-determining region of the Y (SRY+) XX-males, two (SRY-) XX-males, ten 47,XXY Klinefelter men, six 45,X Turner females and ten male and female control individuals each. Methylation analysis was carried out by bisulphite sequencing of DNA from peripheral blood lymphocytes analysing X-inactive-specific transcript (XIST), phosphoglycerate kinase 1 (PGK1), ferritin, heavy peptide-like 17 (FTHL17) and short stature homeobox (SHOX). XIST methylation was 18% in (SRY+) XX-males, and thus they were severely hypomethylated compared to (SRY-) XX-males (48%; P<0.01), Klinefelter men (44%; P<0.01) and female controls (47%; P<0.01). Turner females and male controls displayed a high degree of XIST methylation of 98 and 94% respectively. Methylation of PGK1, undergoing X inactivation, was not significantly reduced in (SRY+) XX-males compared to female controls in spite of severe XIST hypomethylation (51 vs 69%; P>0.05). FTHL17, escaping X inactivation, but undergoing cell-type-specific inactivation was similarly methylated in XX-males (89%), KS patients (87%) and female controls (90%). SHOX, an X inactivation escapee located in the pseudoautosomal region, displays similarly low degrees of methylation for XX-males (7%), KS patients (7%) and female controls (9%). XIST hypomethylation clearly distinguishes (SRY+) XX-males from Klinefelter men. It does not, however, impair appropriate epigenetic regulation of representative X-linked loci.

  14. Changing ideas in forestry: A comparison of concepts in Swedish and American forestry journals during the early twentieth and twenty-first centuries.

    PubMed

    Mårald, Erland; Langston, Nancy; Sténs, Anna; Moen, Jon

    2016-02-01

    By combining digital humanities text-mining tools and a qualitative approach, we examine changing concepts in forestry journals in Sweden and the United States (US) in the early twentieth and early twenty-first centuries. Our first hypothesis is that foresters at the beginning of the twentieth century were more concerned with production and less concerned with ecology than foresters at the beginning of the twenty-first century. Our second hypothesis is that US foresters in the early twentieth century were less concerned with local site conditions than Swedish foresters. We find that early foresters in both countries had broader-and often ecologically focused-concerns than hypothesized. Ecological concerns in the forestry literature have increased, but in the Nordic countries, production concerns have increased as well. In both regions and both time periods, timber management is closely connected to concerns about governance and state power, but the forms that governance takes have changed.

  15. Family Literacy in Early 18th-Century Boston: Cotton Mather and His Children.

    ERIC Educational Resources Information Center

    Monaghan, E. Jennifer

    1991-01-01

    Offers a naturalistic picture of literacy in colonial North America by exploring family literacy in an early eighteenth-century urban New England setting. Uses the diaries and other writings of Cotton Mather (1663-1728) as sources on literacy within his family. Notes the importance of writing within the family. (SR)

  16. 49 CFR 1242.26 - Miscellaneous building and structures (account XX-19-28).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Miscellaneous building and structures (account XX... XX-19-28). Separate common expenses as specific facts indicate or according to distribution of common expenses listed in § 1242.10, Administration-Track (account XX-19-02). ...

  17. The Treatment of the Motion of a Simple Pendulum in Some Early 18th Century Newtonian Textbooks

    ERIC Educational Resources Information Center

    Gauld, Colin

    2004-01-01

    The treatment of pendulum motion in early 18th century Newtonian textbooks is quite different to what we find in today's physics textbooks and is based on presuppositions and mathematical techniques which are not widely used today. In spite of a desire to present Newton's new philosophy of nature as found in his "Principia" 18th century textbook…

  18. Genetics Home Reference: 46,XX testicular disorder of sex development

    MedlinePlus

    ... of sex development 46,XX testicular disorder of sex development Printable PDF Open All Close All Enable ... collapse boxes. Description 46,XX testicular disorder of sex development is a condition in which individuals with ...

  19. Early Twentieth Century Arrow, Javelin, and Dart Games of the Western Native American.

    ERIC Educational Resources Information Center

    Pesavento, Wilma J.

    The general purpose of this study was to determine whether the traditional native American ball games continued to be positive culture traits of the American Indian in the early twentieth century. The investigation was centered about (1) determining the current arrow, javelin, and dart games of western native Americans, (2) determining the…

  20. Two males with SRY-positive 46,XX testicular disorder of sex development.

    PubMed

    Gunes, Sezgin; Asci, Ramazan; Okten, Gülsen; Atac, Fatih; Onat, Onur E; Ogur, Gonul; Aydin, Oguz; Ozcelik, Tayfun; Bagci, Hasan

    2013-02-01

    The 46,XX testicular disorder of sex development (46,XX testicular DSD) is a rare phenotype associated with disorder of the sex chromosomes. We describe the clinical, molecular, and cytogenetic findings of a 16- and a 30-year-old male patient with sex-determining region Y (SRY)-positive 46,XX testicular DSD. Chromosomal analysis revealed 46,XX karyotype. Fluorescence in situ hybridization (FISH) showed the SRY region translocated to the short arm of the X chromosome. The presence of the SRY gene was also confirmed by polymerase chain reaction (PCR). The X chromosome inactivation (XCI) assay showed that both patients have a random pattern of X chromosome inactivation. This report compares the symptoms and features of the SRY-positive 46,XX testicular DSD patients.

  1. Transient development of ovotestes in XX Sox9 transgenic mice.

    PubMed

    Gregoire, Elodie P; Lavery, Rowena; Chassot, Anne-Amandine; Akiyama, Haruhiko; Treier, Mathias; Behringer, Richard R; Chaboissier, Marie-Christine

    2011-01-01

    The sex of an individual results from the paternal transmission of the SRY gene located on the Y chromosome. In turn, SRY initiates Sox9 expression, a transcription factor required for testicular differentiation. Ectopic activation of SOX9 in XX Wt1:Sox9 transgenic mice induces female-to-male sex reversal in adult mice. Here we show that complete sex reversal is preceded by a transient phase of ovotestis differentiation with XX Wt1:Sox9 transgenic gonads containing a testicular central region and one or both ovarian poles indicating that Wt1:Sox9 is not as efficient as Sry to induce male development. In XX Wt1:Sox9(Tg/+) gonads, transgenic Sox9 is expressed earlier than Sox9 in XY gonads and is able to induce the expression of EGFP, knocked into the 3' UTR of Sox9 indicating that SOX9 is involved in the initiation and maintenance of its own expression. However, the delayed onset of expression of endogenous Sox9-EGFP suggests that this activation requires other factors, whose expression depends on SOX9. In the testicular regions of the XX Wt1:Sox9 ovotestes, proliferation of the XX fetal germ cells is hampered and they differentiate as pro-spermatogonia. This indicates that XX germ cells are not competent to respond to proliferative signals released from a testicular environment. In the ovarian regions, despite the continuous mRNA expression of the WT1:Sox9 transgene, the SOX9 protein does not accumulate suggesting that regulation of this gene in ovarian cells involves post-transcriptional mechanisms. Finally, ovarian cells of the XX Wt1:Sox9 ovotestis undergo apoptosis during late embryogenesis leading to complete female-to-male sex reversal of the transgenic mice at birth. Copyright © 2010 Elsevier Inc. All rights reserved.

  2. Transient development of ovotestes in XX Sox9 transgenic mice

    PubMed Central

    Gregoire, Elodie P.; Lavery, Rowena; Chassot, Anne-Amandine; Akiyama, Haruhiko; Treier, Mathias; Behringer, Richard R.; Chaboissier, Marie-Christine

    2010-01-01

    The sex of an individual results from the paternal transmission of the SRY gene located on the Y chromosome. In turn, SRY initiates Sox9 expression, a transcription factor required for testicular differentiation. Ectopic activation of SOX9 in XX Wt1:Sox9 transgenic mice, induces female-to-male sex reversal in adult mice. Here we show that complete sex reversal is preceded by a transient phase of ovotestis differentiation with XX Wt1:Sox9 transgenic gonads containing a testicular central region and one or both ovarian poles indicating that Wt1:Sox9 is not as efficient as Sry to induce male development. In XX Wt1:Sox9Tg/+ gonads, transgenic Sox9 is expressed earlier than Sox9 in XY gonads, and is able to induce the expression of EGFP, knocked into the 3′ UTR of Sox9 indicating that SOX9 is involved in the initiation and maintenance of its own expression. However, the delayed onset of expression of endogenous Sox9-EGFP suggests that this activation requires other factors, whose expression depends on SOX9. In the testicular regions of the XX Wt1:Sox9 ovotestes, proliferation of the XX foetal germ cells is hampered and they differentiate as pro-spermatogonia. This indicates that XX germ cells are not competent to respond to proliferative signals released from a testicular environment. In the ovarian regions, despite the continuous mRNA expression of the WT1:Sox9 transgene, the SOX9 protein does not accumulate suggesting that regulation of this gene in ovarian cells involves post-transcriptional mechanisms. Finally, ovarian cells of the XX Wt1:Sox9 ovotestis undergo apoptosis during late embryogenesis leading to complete female-to-male sex reversal of the transgenic mice at birth. PMID:20965161

  3. A Sociological Look at Biofuels: Ethanol in the Early Decades of the Twentieth Century and Lessons for Today

    ERIC Educational Resources Information Center

    Carolan, Michael S.

    2009-01-01

    This article develops a broad sociological understanding of why biofuels lost out to leaded gasoline as the fuel par excellence of the twentieth century, while drawing comparisons with biofuels today. It begins by briefly discussing the fuel-scape in the United States in the late nineteenth and early twentieth centuries, examining the farm…

  4. Functional response of U.S. grasslands to the early 21st-century drought

    Treesearch

    M. Susan Moran; Guillermo E. Ponce-Campos; Alfredo Huete; Mitchel P. McClaran; Yongguang Zhang; Erik P. Hamerlynck; David J. Augustine; Stacey A. Gunter; Stanley G. Kitchen; Debra P. C. Peters; Patrick J. Starks; Mariano Hernandez

    2014-01-01

    Grasslands across the United States play a key role in regional livelihood and national food security. Yet, it is still unclear how this important resource will respond to the prolonged warm droughts and more intense rainfall events predicted with climate change. The early 21st-century drought in the southwestern United States resulted in hydroclimatic conditions that...

  5. Postnatal outcomes of prenatally diagnosed 45,X/46,XX.

    PubMed

    Tokita, Mari J; Sybert, Virginia P

    2016-05-01

    High quality information is critical for informed decision-making in pregnancy following a prenatal diagnosis of sex chromosome aneuploidy. The goal of this study was to define the spectrum of outcomes in patients with prenatally diagnosed 45,X/46,XX mosaic Turner syndrome in order to provide a better basis for genetic counseling at the time of intrauterine diagnosis. Phenotype data for twenty-five patients with prenatally diagnosed 45,X/46,XX mosaicism were collected by retrospective chart review and, when possible, semi-structured telephone interview. Existing data from a cohort of 58 patients with postnatally diagnosed 45,X/46,XX mosaicism were used for comparison. Relative to those diagnosed postnatally, prenatal patients were more likely to have normal growth and normal secondary sexual development, less likely to manifest distinctive Turner syndrome features such as nuchal webbing and edema, and had significantly fewer renal defects. These differences underscore the need for a nuanced approach to prenatal counseling in cases of 45,X/46,XX mosaicism. © 2016 Wiley Periodicals, Inc.

  6. A rare case of lateral ovotesticular disorder with Klinefelter syndrome mosaicism 46, XX/47, XXY: An unusual presentation.

    PubMed

    Talreja, Shyam M; Banerjee, Indraneel; Yadav, Sher Singh; Tomar, Vinay

    2015-01-01

    Ovotesticular disorder of sex development (OT-DSD) is a rare disorder of sexual differentiation characterized by the presence of both ovarian and testicular tissues in the same individual. It's incidence ranges from 3% to 10% of all disorder of DSD's, and the most common presentation is 46, XX followed by 46, XX/46, XY mosaicism and 46, XY. Klinefelter syndrome (KS) mosaicism 46, XX/47, XXY is extremely rare, and its association with the ovotesticular disorder is even rarer. We report an unusual case of 16-year-old with male habitus who presented with complains of cyclic hematuria. On examination, he had bilateral gynecomastia, unilateral left cryptorchidism, absent facial hair, sparse axillary hair growth, and pubic hair distribution of feminine type. The right testis was of normal size located normally in hemiscrotum and was confirmed by radio imaging. Ultrasonography and magnetic resonance imaging revealed a cystic area behind posterior half of urinary bladder. Chromosomal analysis revealed 46, XX/47, XXY mosaicism of female karyotype and KS. Histopathological report of this left side excised specimen confirmed the structures to be ovary, uterus, and fallopian tube, thus confirming our diagnosis of the lateral ovotesticular disorder. Meticulous workup combined interdisciplinary approach will lead to early diagnosis and resolve timely sex reassignment issues and also prevent consequences arising due to gonadal insufficiency.

  7. Negotiating Assimilation: Chicago Catholic High Schools' Pursuit of Accreditation in the Early Twentieth Century

    ERIC Educational Resources Information Center

    Ryan, Ann Marie

    2006-01-01

    While the national debates over the accreditation of Catholic schools remain an essential element of understanding Catholic education during the early 20th century, this study examines how individuals, groups, and institutions grappled with the perceived need for standardization and increased articulation of schools. In particular, it examines the…

  8. Converting the Rosebud: Sicangu Lakota Catholicism in the Late Nineteenth and Early Twentieth Centuries

    ERIC Educational Resources Information Center

    Markowitz, Harvey

    2012-01-01

    This article discusses a number of the dominant features of late nineteenth- and early twentieth-century Indian Catholicism on the Rosebud Reservation, focusing primarily on the Sicangu's responses to the significant differences between their traditional religious customs and the beliefs, rituals, and requirements of Catholicism. It first examines…

  9. Translation, Hybridization, and Modernization: John Dewey and Children's Literature in Early Twentieth Century China

    ERIC Educational Resources Information Center

    Xu, Xu

    2013-01-01

    This essay examines how John Dewey's child-centered educational philosophy was adopted and adapted in the early twentieth century in China to create a Chinese children's literature. Chinese intellectuals applied Dewey's educational philosophy, which values children's interests and needs, to formulate a new concept of modern childhood that…

  10. Pocketguide to Title XX: Social Services to Children & Youth.

    ERIC Educational Resources Information Center

    Mueller, Candace

    This brief guide to Title XX contains the following chapter headings: (1) Historical Overview of the Social Services Program, (2) The Provisions of Title XX at a Glance, (3) Implications for Services to Children and Youth, (4) The Planning Process, (5) Publication of the Proposed Plan and the Public Comment Period, (6) After the Final Plan is…

  11. [Problem of sexuality in Polish medical aids. The first half of XX century - to 1939].

    PubMed

    Urbanek, Bozena

    2005-01-01

    The article presents an analysis of sexuality-related problems as they are covered in the health guidebooks so well known to her. There are a few topics addressed in Urbanek's text. She describes the evolution of the health guidebooks which was taking place at the end of the 19th and in early 20th centuries and of their users. Women increasingly often were authors and readers of these books. Some of the female authors were medical doctors with an additional passion for writing on public matters. Foreign authors and their works are also mentioned in Urbanek's article. She points to the links between sexology and personal hygiene and even cosmetology. Sexology is present in the guidebooks discussed also as an important ingredient of successful marriage. In this context, Urbanek stresses the changing role of a woman and her strife for acquiring equal rights. Another valuable element in the article is reference to other spheres of culture, such as custom and religion. The 20th century filled these spheres with medical knowledge on childbirth pathologies and their complications. Medical and hygiene-related topics motivate Urbanek to set the question of sexuality in a context of eugenic ideas often debated in the pre-war years. She also points to the multicultural character of the Polish-language health books, identifies various angles of view presented in them, and supports her reflection with well-selected examples. This applies eg. to Soviet books. Although this is not her main subject, Urbanek also writes about health books dealing with sexual matters and destined for men. The author of the article gives a fine description of the variability of sexuality-related contents carried by these books which offered adequate coverage of changes occurring in medical, hygienic, cultural, and even economic fields. The paper is, therefore, not only an analysis of sexuality-related issues but it also presents a broad social context in which these books were conceived and written.

  12. 49 CFR 1242.62 - Clearing wrecks (account XX-51-63).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Clearing wrecks (account XX-51-63). 1242.62 Section 1242.62 Transportation Other Regulations Relating to Transportation (Continued) SURFACE...-Transportation § 1242.62 Clearing wrecks (account XX-51-63). Separate common expenses according to specific...

  13. 49 CFR 1242.86 - Industrial development (account XX-61-90).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Industrial development (account XX-61-90). 1242.86 Section 1242.86 Transportation Other Regulations Relating to Transportation (Continued) SURFACE....86 Industrial development (account XX-61-90). These accounts pertain solely to freight service and...

  14. 49 CFR 1242.69 - Clearing wrecks (account XX-52-63).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Clearing wrecks (account XX-52-63). 1242.69 Section 1242.69 Transportation Other Regulations Relating to Transportation (Continued) SURFACE...-Transportation § 1242.69 Clearing wrecks (account XX-52-63). Separate common expenses according to specific...

  15. XX model on the circle

    NASA Astrophysics Data System (ADS)

    de Pasquale, A.; Costantini, G.; Facchi, P.; Florio, G.; Pascazio, S.; Yuasa, K.

    2008-07-01

    We diagonalize the XX model with a finite number of spins and periodic boundary conditions. We solve for the ground state, focus on the rapidity of the convergence to the thermodynamic limit and study the features of multipartite entanglement.

  16. "Are You Only an Applauder?" American Music Correspondence Schools in the Early Twentieth Century

    ERIC Educational Resources Information Center

    Vogel, Dorothy

    2015-01-01

    The purpose of this study was to examine correspondence schools of music in the early twentieth century. Advertisements in widely circulated household and music periodicals and archival copies of courses from Siegel-Myers Correspondence School of Music, United States School of Music, American College of Music, and others were examined. Research…

  17. 49 CFR 1242.57 - Dispatching trains (account XX-51-58).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Dispatching trains (account XX-51-58). 1242.57 Section 1242.57 Transportation Other Regulations Relating to Transportation (Continued) SURFACE...-Transportation § 1242.57 Dispatching trains (account XX-51-58). Separate common expenses on the basis of train...

  18. 46,XX male disorder of sexual development:a case report.

    PubMed

    Anık, Ahmet; Çatlı, Gönül; Abacı, Ayhan; Böber, Ece

    2013-01-01

    The main factor influencing sex determination of an embryo is the sex-determining region Y (SRY), a master regulatory gene located on the Y chromosome. The presence of SRY causes the bipotential gonad to differentiate into a testis. However, some individuals carry a Y chromosome but are phenotypically female (46,XY females) or have a female karyotype but are phenotypically male (46,XX males). 46, XX male is rare (1:20 000 in newborn males), and SRY positivity is responsible for this condition in approximately 90% of these subjects. External genitalia of 46,XX SRY-positive males appear as normal male external genitalia, and such cases are diagnosed when they present with small testes and/or infertility after puberty. Herein, we report an adolescent who presented with low testicular volume and who was diagnosed as a 46,XX male. SRY positivity was demonstrated in the patient by fluorescence in situ hybridization method.

  19. Comprehensive Social Service Programs for Handicapped Citizens through Title XX.

    ERIC Educational Resources Information Center

    Roten, Shelby Jean

    Reviewed are present and potential services and social programs for handicapped children in Mississippi through purchase of service contracts under Title XX of the Social Security Act. Sections cover the following topics: background and purpose of Title XX which gives states greater control over social service programs, planning state supported…

  20. Isodicentric Y mosaicism involving a 46, XX cell line: Implications for management.

    PubMed

    Hipp, Lauren E; Mohnach, Lauren H; Wei, Sainan; Thomas, Inas H; Elhassan, Maha E; Sandberg, David E; Quint, Elisabeth H; Keegan, Catherine E

    2016-01-01

    Carriers of isodicentric Y (idicY) mosaicism exhibit a wide range of clinical features, including short stature, gonadal abnormalities, and external genital anomalies. However, the phenotypic spectrum for individuals carrying an idicY and a 46, XX cell line is less clearly defined. A more complete description of the phenotype related to idicY is thus essential to guide management related to pubertal development, fertility, and gonadoblastoma risk in mosaic carriers. Findings from the evaluation of twin females with an abnormal karyotype, 48, XX, +idic(Yq) x2/47, XX, +idic(Yq)/46, XX, are presented to highlight the importance of interdisciplinary care in the management of multifaceted disorders of sex development. © 2015 Wiley Periodicals, Inc.

  1. 49 CFR 1242.48 - Work and other non-revenue equipment (account XX-27-47).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Work and other non-revenue equipment (account XX... RAILROADS 1 Operating Expenses-Equipment § 1242.48 Work and other non-revenue equipment (account XX-27-47...—other (account XX-19-06). ...

  2. 49 CFR 1242.10 - Administration-track (account XX-19-02).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... accounts are separated between freight and passenger services: Roadway: Running (XX-17-10) Switching (XX-18-10) Ties: Running (21-17-13) Switching (21-18-13) Rails: Running (21-17-14) Switching (21-18-14) Other Track Materials: Running (21-17-15) Switching (21-18-15) Ballast: Running (21-17-16) Switching (21...

  3. 49 CFR 1242.10 - Administration-track (account XX-19-02).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... accounts are separated between freight and passenger services: Roadway: Running (XX-17-10) Switching (XX-18-10) Ties: Running (21-17-13) Switching (21-18-13) Rails: Running (21-17-14) Switching (21-18-14) Other Track Materials: Running (21-17-15) Switching (21-18-15) Ballast: Running (21-17-16) Switching (21...

  4. The National Guard: An Operational Force for the 21st Century

    DTIC Science & Technology

    2013-03-01

    does not display a currently valid OMB control number . PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) xx-03-2013...Force for the 21st Century 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Colonel Verne C. McMoarn Army...National Guard 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Dr. Anna

  5. Surviving the Lunacy Act of 1890: English Psychiatrists and Professional Development during the Early Twentieth Century.

    PubMed

    Takabayashi, Akinobu

    2017-04-01

    In recent decades, historians of English psychiatry have shifted their major concerns away from asylums and psychiatrists in the nineteenth century. This is also seen in the studies of twentieth-century psychiatry where historians have debated the rise of psychology, eugenics and community care. This shift in interest, however, does not indicate that English psychiatrists became passive and unimportant actors in the last century. In fact, they promoted Lunacy Law reform for a less asylum-dependent mode of psychiatry, with a strong emphasis on professional development. This paper illustrates the historical dynamics around the professional development of English psychiatry by employing Andrew Abbott's concept of professional development. Abbott redefines professional development as arising from both abstraction of professional knowledge and competition regarding professional jurisdiction. A profession, he suggests, develops through continuous re-formation of its occupational structure, mode of practice and political language in competing with other professional and non-professional forces. In early twentieth-century England, psychiatrists promoted professional development by framing political discourse, conducting a daily trade and promoting new legislation to defend their professional jurisdiction. This professional development story began with the Lunacy Act of 1890, which caused a professional crisis in psychiatry and led to inter-professional competition with non-psychiatric medical service providers. To this end, psychiatrists devised a new political rhetoric, 'early treatment of mental disorder', in their professional interests and succeeded in enacting the Mental Treatment Act of 1930, which re-instated psychiatrists as masters of English psychiatry.

  6. Title XX: Social Services in Your State. A Child Advocate's Handbook for Action.

    ERIC Educational Resources Information Center

    Children's Defense Fund, Washington, DC.

    This booklet is a guide for those wishing to route Title XX money into the community programs for children. Part I discusses ways for child advocates to participate in four key stages of the Title XX planning process in their state: planning proposals, raising the 25% non-federal share of the funds required by Title XX, and publishing proposed and…

  7. Speaking American: Comparing Supreme Court and Hollywood Racial Interpretation in the Early Twenty-First Century

    ERIC Educational Resources Information Center

    Hawkins, Paul Henry

    2010-01-01

    Apprehending that race is social, not biological, this study examines U.S. racial formation in the early twenty-first century. In particular, Hollywood and Supreme Court texts are analyzed as media for gathering, shaping and transmitting racial ideas. Representing Hollywood, the 2004 film "Crash" is analyzed. Representing the Supreme Court, the…

  8. Reconstructing early 17th century estuarine drought conditions from Jamestown oysters.

    PubMed

    Harding, Juliana M; Spero, Howard J; Mann, Roger; Herbert, Gregory S; Sliko, Jennifer L

    2010-06-08

    Oysters (Crassostrea virginica) were a central component of the Chesapeake Bay ecosystem in 1607 when European settlers established Jamestown, VA, the first permanent English settlement in North America. These estuarine bivalves were an important food resource during the early years of the James Fort (Jamestown) settlement while the colonists were struggling to survive in the face of inadequate supplies and a severe regional drought. Although oyster shells were discarded as trash after the oysters were eaten, the environmental and ecological data recorded in the bivalve geochemistry during shell deposition remain intact over centuries, thereby providing a unique window into conditions during the earliest Jamestown years. We compare oxygen isotope data from these 17th century oyster shells with modern shells to quantify and contrast estuarine salinity, season of oyster collection, and shell provenance during Jamestown colonization (1609-1616) and the 21st century. Data show that oysters were collected during an extended drought between fall 1611 and summer 1612. The drought shifted the 14 psu isohaline above Jamestown Island, facilitating individual oyster growth and extension of oyster habitat upriver toward the colony, thereby enhancing local oyster food resources. Data from distinct well layers suggest that the colonists also obtained oysters from reefs near Chesapeake Bay to augment oyster resources near Jamestown Island. The oyster shell season of harvest reconstructions suggest that these data come from either a 1611 well with a very short useful period or an undocumented older well abandoned by late 1611.

  9. 49 CFR 1242.22 - Shop buildings-locomotives (account XX-19-24).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 9 2013-10-01 2013-10-01 false Shop buildings-locomotives (account XX-19-24). 1242.22 Section 1242.22 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.22 Shop buildings—locomotives (account XX-19-24). Separate common expenses according to...

  10. 49 CFR 1242.22 - Shop buildings-locomotives (account XX-19-24).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 9 2011-10-01 2011-10-01 false Shop buildings-locomotives (account XX-19-24). 1242.22 Section 1242.22 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.22 Shop buildings—locomotives (account XX-19-24). Separate common expenses according to...

  11. 49 CFR 1242.22 - Shop buildings-locomotives (account XX-19-24).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 9 2012-10-01 2012-10-01 false Shop buildings-locomotives (account XX-19-24). 1242.22 Section 1242.22 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.22 Shop buildings—locomotives (account XX-19-24). Separate common expenses according to...

  12. 49 CFR 1242.22 - Shop buildings-locomotives (account XX-19-24).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 9 2014-10-01 2014-10-01 false Shop buildings-locomotives (account XX-19-24). 1242.22 Section 1242.22 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.22 Shop buildings—locomotives (account XX-19-24). Separate common expenses according to...

  13. Illustrating phallic worship: uses of material objects and the production of sexual knowledge in eighteenth-century antiquarianism and early twentieth-century sexual science.

    PubMed

    Funke, Jana; Fisher, Kate; Grove, Jen; Langlands, Rebecca

    2017-07-03

    This article reveals previously overlooked connections between eighteenth-century antiquarianism and early twentieth-century sexual science by presenting a comparative reading of two illustrated books: An Account of the Remains of the Worship of Priapus , by British antiquarian scholar Richard Payne Knight (1750-1824), and Die Weltreise eines Sexualforschers (The World Journey of a Sexologist), by German sexual scientist Magnus Hirschfeld (1868-1935). A close analysis of these publications demonstrates the special status of material artefacts and the strategic engagement with visual evidence in antiquarian and scientific writings about sex. Through its exploration of the similarities between antiquarian and sexual scientific thought, the article demonstrates the centrality of material culture to the production of sexual knowledge in the Western world. It also opens up new perspectives on Western intellectual history and on the intellectual origins of sexual science. While previous scholarship has traced the beginnings of sexual science back to nineteenth-century medical disciplines, this article shows that sexual scientists drew upon different forms of evidence and varied methodologies to produce sexual knowledge and secure scientific authority. As such, sexual science needs to be understood as a field with diverse intellectual roots that can be traced back (at least) to the eighteenth century.

  14. Illustrating phallic worship: uses of material objects and the production of sexual knowledge in eighteenth-century antiquarianism and early twentieth-century sexual science

    PubMed Central

    Funke, Jana; Fisher, Kate; Grove, Jen; Langlands, Rebecca

    2017-01-01

    Abstract This article reveals previously overlooked connections between eighteenth-century antiquarianism and early twentieth-century sexual science by presenting a comparative reading of two illustrated books: An Account of the Remains of the Worship of Priapus, by British antiquarian scholar Richard Payne Knight (1750–1824), and Die Weltreise eines Sexualforschers (The World Journey of a Sexologist), by German sexual scientist Magnus Hirschfeld (1868–1935). A close analysis of these publications demonstrates the special status of material artefacts and the strategic engagement with visual evidence in antiquarian and scientific writings about sex. Through its exploration of the similarities between antiquarian and sexual scientific thought, the article demonstrates the centrality of material culture to the production of sexual knowledge in the Western world. It also opens up new perspectives on Western intellectual history and on the intellectual origins of sexual science. While previous scholarship has traced the beginnings of sexual science back to nineteenth-century medical disciplines, this article shows that sexual scientists drew upon different forms of evidence and varied methodologies to produce sexual knowledge and secure scientific authority. As such, sexual science needs to be understood as a field with diverse intellectual roots that can be traced back (at least) to the eighteenth century. PMID:29393929

  15. Cancer screening and early detection in the 21st century

    PubMed Central

    Murphy, Jeanne

    2017-01-01

    Objective To review the trends in and principles of cancer screening and early detection. Data Sources Journal articles, United States Preventive Services Task Force (U SPSTF) publications, professional organization position statements, evidence-based summaries Conclusion Cancer screening has contributed to decreasing the morbidity and mortality of cancer. Efforts to improve the selection of candidates for cancer screening, to understand the biological basis of carcinogenesis, and the development of new technologies for cancer screening will allow for improvements in the cancer screening over time. Implications for Nursing Practice Nurses are well-positioned to lead the implementation of cancer screening recommendations in the 21st Century through their practice, research, educational efforts and advocacy. PMID:28343835

  16. Potentially induced earthquakes during the early twentieth century in the Los Angeles Basin

    USGS Publications Warehouse

    Hough, Susan E.; Page, Morgan T.

    2016-01-01

    Recent studies have presented evidence that early to mid‐twentieth‐century earthquakes in Oklahoma and Texas were likely induced by fossil fuel production and/or injection of wastewater (Hough and Page, 2015; Frohlich et al., 2016). Considering seismicity from 1935 onward, Hauksson et al. (2015) concluded that there is no evidence for significant induced activity in the greater Los Angeles region between 1935 and the present. To explore a possible association between earthquakes prior to 1935 and oil and gas production, we first revisit the historical catalog and then review contemporary oil industry activities. Although early industry activities did not induce large numbers of earthquakes, we present evidence for an association between the initial oil boom in the greater Los Angeles area and earthquakes between 1915 and 1932, including the damaging 22 June 1920 Inglewood and 8 July 1929 Whittier earthquakes. We further consider whether the 1933 Mw 6.4 Long Beach earthquake might have been induced, and show some evidence that points to a causative relationship between the earthquake and activities in the Huntington Beach oil field. The hypothesis that the Long Beach earthquake was either induced or triggered by an foreshock cannot be ruled out. Our results suggest that significant earthquakes in southern California during the early twentieth century might have been associated with industry practices that are no longer employed (i.e., production without water reinjection), and do not necessarily imply a high likelihood of induced earthquakes at the present time.

  17. Should we question early feminizing genitoplasty for patients with congenital adrenal hyperplasia and XX karyotype?

    PubMed

    Binet, A; Lardy, H; Geslin, D; Francois-Fiquet, C; Poli-Merol, M L

    2016-03-01

    There is a wide difference of opinion between the medical-surgical community and advocacy group regarding Disorders of Sexual Development (DSD) secondary to congenital adrenal hyperplasia (CAH) being ranked in the intersex category. This rupture is even more evident when the issue of genitoplasty is brought up. For physicians it is obvious and unequivocal that a person with CAH and an XX karyotype has a female gender identity, whereas associations tend to rank persons with CAH in the intersex category and advocate holding-off on surgical management. A retrospective case study vs. control group, spanning over 40years, included 21 patients who were treated in 3 different centers. Each patient and their parents were contacted independently and interviewed regarding interpersonal relationships, psychological impact of genitoplasty, gender identity and opinion on optimal care management for this disorder. Three couples controls (parent-child) per CAH patients were used and matched according to age, sex assigned at birth and ethnic origin. Sex assigned at birth seemed to concord with the gender identity perceived by the patients in 85.7% of cases. In fact, 89.7% of patients and 100% of parents felt that feminizing genitoplasty should be performed within the first year of life. There is however a significant difference compared to controls who felt that surgical management should occur later on in life. No difference was highlighted during childhood regarding parents-child relationships or social integration. However, during adolescence, the parents-child relationship tended to be significantly more painful for the CAH group. Integrating their parenting role was significantly harder for patients in the CAH-DSD group. In the population of CAH-DSD patients who had genitoplasty the level of sexual fulfillment was not lower to the one reported by the control group. Female sex assignment seems legitimate according to this study and the development of gender identity in these

  18. Late nineteenth to early twenty-first century behavior of Alaskan glaciers as indicators of changing regional climate

    USGS Publications Warehouse

    Molnia, B.F.

    2007-01-01

    Alaska's climate is changing and one of the most significant indications of this change has been the late 19th to early 21st century behavior of Alaskan glaciers. Weather station temperature data document that air temperatures throughout Alaska have been increasing for many decades. Since the mid-20th century, the average change is an increase of ?????2.0????C. In order to determine the magnitude and pattern of response of glaciers to this regional climate change, a comprehensive analysis was made of the recent behavior of hundreds of glaciers located in the eleven Alaskan mountain ranges and three island areas that currently support glaciers. Data analyzed included maps, historical observations, thousands of ground-and-aerial photographs and satellite images, and vegetation proxy data. Results were synthesized to determine changes in length and area of individual glaciers. Alaskan ground photography dates from 1883, aerial photography dates from 1926, and satellite photography and imagery dates from the early 1960s. Unfortunately, very few Alaskan glaciers have any mass balance observations. In most areas analyzed, every glacier that descends below an elevation of ?????1500??m is currently thinning and/or retreating. Many glaciers have an uninterrupted history of continuous post-Little-Ice-Age retreat that spans more than 250??years. Others are characterized by multiple late 19th to early 21st century fluctuations. Today, retreating and/or thinning glaciers represent more than 98% of the glaciers examined. However, in the Coast Mountains, St. Elias Mountains, Chugach Mountains, and the Aleutian Range more than a dozen glaciers are currently advancing and thickening. Many currently advancing glaciers are or were formerly tidewater glaciers. Some of these glaciers have been expanding for more than two centuries. This presentation documents the post-Little-Ice-Age behavior and variability of the response of many Alaskan glaciers to changing regional climate. ?? 2006.

  19. The study of documentary photographs of the early 20th century by the optical coherence microscopy method

    NASA Astrophysics Data System (ADS)

    Ryseva, Ekaterina; Zhukova, Ekaterina

    2013-05-01

    The wide field and spectral methods of optical coherence microscopy were used for extensive studying the photographs printed in the early 20th century. Tomographic images (B-scans) of photo and paper materials are presented and discussed.

  20. Surviving the Lunacy Act of 1890: English Psychiatrists and Professional Development during the Early Twentieth Century

    PubMed Central

    Takabayashi, Akinobu

    2017-01-01

    In recent decades, historians of English psychiatry have shifted their major concerns away from asylums and psychiatrists in the nineteenth century. This is also seen in the studies of twentieth-century psychiatry where historians have debated the rise of psychology, eugenics and community care. This shift in interest, however, does not indicate that English psychiatrists became passive and unimportant actors in the last century. In fact, they promoted Lunacy Law reform for a less asylum-dependent mode of psychiatry, with a strong emphasis on professional development. This paper illustrates the historical dynamics around the professional development of English psychiatry by employing Andrew Abbott’s concept of professional development. Abbott redefines professional development as arising from both abstraction of professional knowledge and competition regarding professional jurisdiction. A profession, he suggests, develops through continuous re-formation of its occupational structure, mode of practice and political language in competing with other professional and non-professional forces. In early twentieth-century England, psychiatrists promoted professional development by framing political discourse, conducting a daily trade and promoting new legislation to defend their professional jurisdiction. This professional development story began with the Lunacy Act of 1890, which caused a professional crisis in psychiatry and led to inter-professional competition with non-psychiatric medical service providers. To this end, psychiatrists devised a new political rhetoric, ‘early treatment of mental disorder’, in their professional interests and succeeded in enacting the Mental Treatment Act of 1930, which re-instated psychiatrists as masters of English psychiatry. PMID:28260566

  1. Sex determination and disorders of sex development according to the revised nomenclature and classification in 46,XX individuals.

    PubMed

    Kousta, Eleni; Papathanasiou, Asteroula; Skordis, Nicos

    2010-01-01

    There have been considerable advances concerning understanding of the early and later stages of ovarian development; a number of genes have been implicated and their mutations have been associated with developmental abnormalities. The most important genes controlling the initial phase of gonadal development, identical in females and males, are Wilms' tumor suppressor 1 (WT1) and steroidogenic factor 1 (SF1). Four genes are likely to be involved in the subsequent stages of ovarian development (WNT4, DAX1, FOXL2 and RSPO1), but none is yet proven to be the ovarian determining factor. Changes in nomenclature and classification were recently proposed in order to incorporate genetic advances and substitute gender-based diagnostic labels in terminology. The term "disorders of sex development" (DSD) is proposed to substitute the previous term "intersex disorders". Three main categories have been used to describe DSD in the 46,XX individual: 1) disorders of gonadal (ovarian) development: ovotesticular DSD, previously named true hermaphroditism, testicular DSD, previously named XX males, and gonadal dysgenesis; 2) disorders related to androgen excess (congenital adrenal hyperplasia, aromatase deficiency and P450 oxidoreductase deficiency); and 3) other rare disorders. In this mini-review, recent advances concerning development of the genital system in 46,XX individuals and related abnormalities are discussed. Basic embryology of the ovary and molecular pathways determining ovarian development are reviewed, focusing on mutations disrupting normal ovarian development. Disorders of sex development according to the revised nomenclature and classification in 46,XX individuals are summarized, including genetic progress in the field.

  2. History in the Early Nineteenth Century.

    PubMed

    Ratcliff, Jessica

    2016-09-01

    At the turn of the nineteenth century, at its headquarters in the City of London, the Honourable East India Company established a new museum and library. By midcentury this museum would contain one of Europe’s most extensive collections of the natural history, arts, and sciences of Asia. This essay uses the early history of the company’s museum, focusing in particular on its natural history collections, to explore the material relationship between scientific practice and the imperial political economy. Much of the collections had been gathered in the wake of military campaigns, trade missions, or administrative surveys. Once specimens and reports arrived in Leadenhall Street and passed through the museum storage areas, this plunder would become the stuff of science, going on to feed the growth of disciplines, societies, and projects in Britain and beyond. In this way, the East India Company was integral to the information and communication infrastructures within which many sciences then operated. Collections-based disciplines and societies flourished in this period; their growth, it is argued, was coextensive with administrative and political economic change at institutions like the East India Company. The essay first explores the company’s practices and patterns of collecting and then considers the consequences of this accumulation for aspects of scientific practice—particularly the growth of scientific societies—in both London and Calcutta.

  3. Identification of SOX3 as an XX male sex reversal gene in mice and humans.

    PubMed

    Sutton, Edwina; Hughes, James; White, Stefan; Sekido, Ryohei; Tan, Jacqueline; Arboleda, Valerie; Rogers, Nicholas; Knower, Kevin; Rowley, Lynn; Eyre, Helen; Rizzoti, Karine; McAninch, Dale; Goncalves, Joao; Slee, Jennie; Turbitt, Erin; Bruno, Damien; Bengtsson, Henrik; Harley, Vincent; Vilain, Eric; Sinclair, Andrew; Lovell-Badge, Robin; Thomas, Paul

    2011-01-01

    Sex in mammals is genetically determined and is defined at the cellular level by sex chromosome complement (XY males and XX females). The Y chromosome-linked gene sex-determining region Y (SRY) is believed to be the master initiator of male sex determination in almost all eutherian and metatherian mammals, functioning to upregulate expression of its direct target gene Sry-related HMG box-containing gene 9 (SOX9). Data suggest that SRY evolved from SOX3, although there is no direct functional evidence to support this hypothesis. Indeed, loss-of-function mutations in SOX3 do not affect sex determination in mice or humans. To further investigate Sox3 function in vivo, we generated transgenic mice overexpressing Sox3. Here, we report that in one of these transgenic lines, Sox3 was ectopically expressed in the bipotential gonad and that this led to frequent complete XX male sex reversal. Further analysis indicated that Sox3 induced testis differentiation in this particular line of mice by upregulating expression of Sox9 via a similar mechanism to Sry. Importantly, we also identified genomic rearrangements within the SOX3 regulatory region in three patients with XX male sex reversal. Together, these data suggest that SOX3 and SRY are functionally interchangeable in sex determination and support the notion that SRY evolved from SOX3 via a regulatory mutation that led to its de novo expression in the early gonad.

  4. Identification of SOX3 as an XX male sex reversal gene in mice and humans

    PubMed Central

    Sutton, Edwina; Hughes, James; White, Stefan; Sekido, Ryohei; Tan, Jacqueline; Arboleda, Valerie; Rogers, Nicholas; Knower, Kevin; Rowley, Lynn; Eyre, Helen; Rizzoti, Karine; McAninch, Dale; Goncalves, Joao; Slee, Jennie; Turbitt, Erin; Bruno, Damien; Bengtsson, Henrik; Harley, Vincent; Vilain, Eric; Sinclair, Andrew; Lovell-Badge, Robin; Thomas, Paul

    2010-01-01

    Sex in mammals is genetically determined and is defined at the cellular level by sex chromosome complement (XY males and XX females). The Y chromosome–linked gene sex-determining region Y (SRY) is believed to be the master initiator of male sex determination in almost all eutherian and metatherian mammals, functioning to upregulate expression of its direct target gene Sry-related HMG box–containing gene 9 (SOX9). Data suggest that SRY evolved from SOX3, although there is no direct functional evidence to support this hypothesis. Indeed, loss-of-function mutations in SOX3 do not affect sex determination in mice or humans. To further investigate Sox3 function in vivo, we generated transgenic mice overexpressing Sox3. Here, we report that in one of these transgenic lines, Sox3 was ectopically expressed in the bipotential gonad and that this led to frequent complete XX male sex reversal. Further analysis indicated that Sox3 induced testis differentiation in this particular line of mice by upregulating expression of Sox9 via a similar mechanism to Sry. Importantly, we also identified genomic rearrangements within the SOX3 regulatory region in three patients with XX male sex reversal. Together, these data suggest that SOX3 and SRY are functionally interchangeable in sex determination and support the notion that SRY evolved from SOX3 via a regulatory mutation that led to its de novo expression in the early gonad. PMID:21183788

  5. Comparing early twentieth century and present-day atmospheric pollution in SW France: A story of lichens.

    PubMed

    Agnan, Y; Séjalon-Delmas, N; Probst, A

    2013-01-01

    Lichens have long been known to be good indicators of air quality and atmospheric deposition. Xanthoria parietina was selected to investigate past (sourced from a herbarium) and present-day trace metal pollution in four sites from South-West France (close to Albi). Enrichment factors, relationships between elements and hierarchical classification indicated that the atmosphere was mainly impacted by coal combustion (as shown by As, Pb or Cd contamination) during the early twentieth century, whereas more recently, another mixture of pollutants (e.g. Sb, Sn, Pb and Cu) from local factories and car traffic has emerged. The Rare Earth Elements (REE) and other lithogenic elements indicated a higher dust content in the atmosphere in the early twentieth century and a specific lithological local signature. In addition to long-range atmospheric transport, local urban emissions had a strong impact on trace element contamination registered in lichens, particularly for contemporary data. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. 49 CFR 1242.35 - Repair and maintenance (account XX-26-41).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Repair and maintenance (account XX-26-41). 1242.35...-Equipment § 1242.35 Repair and maintenance (account XX-26-41). (a) Where the carrier maintains records of... locomotive units or classes of locomotive units are used exclusively in road-freight, road-passenger, yard...

  7. 49 CFR 1242.19 - Electric power systems (account XX-19-21).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Electric power systems (account XX-19-21). 1242.19... OPERATING EXPENSES BETWEEN FREIGHT SERVICE AND PASSENGER SERVICE FOR RAILROADS 1 Operating Expenses-Way and Structures § 1242.19 Electric power systems (account XX-19-21). Separate common expenses on basis of common...

  8. 75 FR 67165 - Proposed Collection; Comment Request for Revenue Procedure2007-XX (RP-155430-05)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-01

    ... Revenue Procedure 2007- XX (RP-155430-05) AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice... soliciting comments concerning Revenue Procedure 2007-XX (RP-155430-05), Section 6707/6707A Accelerated... Procedure 2007-XX (RP-155430-05). Abstract: The collection of information this revenue procedure requires is...

  9. Remembering and forgetting Freud in early twentieth-century dreams.

    PubMed

    Forrester, John

    2006-03-01

    The paper explores the use of Freud's methods of dream interpretation by four English writers of the early twentieth century: T. H. Pear, W. H. R. Rivers, Ernest Jones, and Alix Strachey. Each employed their own dreams in rather different ways: as part of an assessment of Freud's work as a psychological theory, as illustrative of the cogency of Freud's method and theories as part of the psychoanalytic process. Each adopted different approaches to the question of privacy and decorum. The paper argues that assessment of the impact of Freud's work must take account of the application of the method to the researcher's own dreams and the personal impact this process of analysis had upon them, and must also gauge how the dreamers' deployment of Freud's methods influenced their explicit relationship to him and his theories.

  10. One-Way Deficit and Quantum Phase Transitions in XX Model

    NASA Astrophysics Data System (ADS)

    Wang, Yao-Kun; Zhang, Yu-Ran

    2018-02-01

    Quantum correlations including entanglement and quantum discord have drawn much attention in characterizing quantum phase transitions. Quantum deficit originates in questions regarding work extraction from quantum systems coupled to a heat bath (Oppenheim et al. Phys. Rev. Lett. 89, 180402, 2002). It links quantum thermodynamics with quantum correlations and provides a new standpoint for understanding quantum non-locality. In this paper, we evaluate the one-way deficit of two adjacent spins in the bulk for the XX model. In the thermodynamic limit, the XX model undergoes a first order transition from fully polarized to a critical phase with quasi-long-range order with decrease of quantum parameter. We find that the one-way deficit becomes nonzero after the critical point. Therefore, the one-way deficit characterizes the quantum phase transition in the XX model.

  11. The genetics of XX gonadal dysgenesis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aittomaeki, K.

    1994-05-01

    In a nationwide population-based study of women born between 1950 and 1976, 75 patients with XX gonadal dysgenesis (XXGD) were identified in Finland. Patients were ascertained through hospital records and the registers of chromosome laboratories. In one family 4 daughters were affected; in six families 2 daughters were affected; and 57 cases were isolated. In one additional family the two affected females were in successive generations. Population records were utilized to trace ancestors of patients back to the beginning of the 19th century, in most cases. Consanguinity was detected in 8 (12%) of 66 families. When females only are considered,more » the segregation analyses yield a proportion of .23 affected. The relatively large number of affected individuals identified (incidence 1 in 8,300 live-born girls) implies a high gene frequency in the Finnish population. The geographic distribution was highly uneven, with most families originating in the sparsely populated north-central part of Finland. These findings support the existence of an autosomal recessive (XXGD) gene (locus designation [open quotes]ODG1[close quotes]) that is highly enriched in Finland. The multiplex families already identified will make it possible to map the ODG1 gene by a random search for linkage by using polymorphic markers. Linkage-disequilibrium analysis in the sporadic patients will then be used to test for genetic homogeneity versus heterogeneity. 27 refs., 3 figs.« less

  12. Looking White and Middle-Class: Stereoscopic Imagery and Technology in the Early Twentieth-Century United States

    ERIC Educational Resources Information Center

    Malin, Brenton J.

    2007-01-01

    This essay explores a series of discourses surrounding the images of the early twentieth-century stereoscope, focusing on Underwood & Underwood of Ottawa, Kansas, and the Keystone View Company, of Meadville, Pennsylvania. By publishing images of particular geographic areas and historical events, as well as compendium volumes that included…

  13. Hospitals of Rome in the Early Nineteenth Century: The Apostolic Visit of 1825.

    PubMed

    Duffin, Jacalyn

    2016-01-01

    Pope Leo XII marked the 1825 Jubilee by visiting the hospitals of Rome. Italy was recovering from the French invasion that had disrupted social and religious structures. The Visitors investigated conditions, and recommended changes. By 1826, eight large hospitals were ordered to unite, but, three years later, the order was rescinded. Based on the Visit's mostly unexamined records in the Vatican Secret Archives, hospital registers, and minutes of the governing council held in the Archivio di Stato di Roma, this paper reconstructs the network of Rome's hospitals in the early 19 th century. It also compares Roman hospitals to its Parisian counterparts, especially with respect to governance and education. Finally, it examines the merger as an early example of a practice that remains vibrant (if controversial) today.

  14. Development of the LSF95xx 2nd generation flexure bearing coolers

    NASA Astrophysics Data System (ADS)

    Mullie, J. C.; Bruins, P. C.; Benschop, T.; Meijers, M.

    2005-05-01

    Thales Cryogenics has been working on high reliability cryocoolers since 1997. During this period two cooler series have been developed, the LSF91xx series for cooling powers up to 3W at 80K and the LSF93xx series for cooling powers up to 8W at 80K. As a result of several design improvements, it was possible to decrease the length and mass of our flexure-bearing coolers. These improvements have been applied in the new LSF95xx series. With the length and mass reduction, the LSF95xx complies with the SADA II specification with respect to envelope and mass. Based on this, Thales Cryogenics is the first manufacturer offering a full flexure-bearing supported cooler that fits within the SADA II envelope. By using a moving magnet configuration in all our flexure-bearing coolers, the risk with respect to contamination problems due to out-gassing has been diminished because the coils are not part of the helium circuit. Furthermore, all connections in the LSF95xx are laser-welded, which means that there is no additional locking required inside the cooler. By using a different magnet design, no magnet segments have to be glued together, which decreases the risk of out-gassing and increases the reliability even more. This paper describes the trade-offs that have been considered in the design phase, and gives a detailed overview of the test results, the status of the qualification program and the resulting specification of the LSF95xx cooler series.

  15. 49 CFR 1242.11 - Administration-bridges and buildings (account XX-19-03).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 9 2011-10-01 2011-10-01 false Administration-bridges and buildings (account XX... RAILROADS 1 Operating Expenses-Way and Structures § 1242.11 Administration—bridges and buildings (account XX-19-03). Separate common administration—bridges and buildings expenses between freight and passenger...

  16. 49 CFR 1242.11 - Administration-bridges and buildings (account XX-19-03).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Administration-bridges and buildings (account XX... RAILROADS 1 Operating Expenses-Way and Structures § 1242.11 Administration—bridges and buildings (account XX-19-03). Separate common administration—bridges and buildings expenses between freight and passenger...

  17. A comparative genomic hybridization study in a 46,XX male.

    PubMed

    Rigola, M Angels; Carrera, Marta; Ribas, Isabel; Egozcue, Josep; Miró, Rosa; Fuster, Carme

    2002-07-01

    To identify Y chromosome material in an azoospermic male with an XX karyotype. Case report. Faculty of medicine and Centro de Patologia Celular (CPC) medical center. A 33-year-old man with infertility. G-banding, fluorescence in situ hybridization (FISH), polymerase chain reaction (PCR), and comparative genomic hybridization (CGH). FISH for X and Y chromosomes, PCR for the SRYgene and amelogenin gene in the Xp (AMGX) and (AMGY), and losses or gains with CGH. FISH analysis using X and Y chromosome-specific probes showed an X chromosome containing Y chromosome sequences on the top of the short arm; this Y chromosome region was not visible by conventional cytogenetic analysis. PCR amplification of DNA showed the presence of the sex-determining region of the Y chromosome (SRY) and the amelogenin gene in the pseudoautosomal boundary of the X chromosome (AMGX). CGH confirmed the presence of the chromosome region Yp11.2-pter and detected the presence of the two otherwise normal X chromosomes. The two Xpter (XPAR1) pseudoautosomal regions present in this XX male suggest the need to reevaluate XX males using CGH and PCR to characterize the clinical variability in XX males due to genes other than those located on the Y chromosome.

  18. Syphilis and psychiatry at the Mysore Government Mental Hospital (NIMHANS) in the early 20th century

    PubMed Central

    Ghani, Sarah; Murthy, Pratima; Jain, Sanjeev; Sarin, Alok

    2018-01-01

    Prior to the advent of the Wasserman Test as a diagnostic tool for Syphilis, the identification rate for Syphilis at the Mysore Government Mental Hospital in Southern India was 1%. With the introduction of the test, there was a dramatic increase in the diagnosis of Syphilis, with 17% of the patients testing positive. This paper throws light on the early notions of Syphilis and GPI, societal responses to the disease, early misdiagnosis, the advent of the Wasserman test and treatment management as reflected in the records of the early 20th century at the Mysore Government Mental Hospital (currently known as NIMHANS). PMID:29527060

  19. Tragic mathematics: romantic narratives and the refounding of mathematics in the early nineteenth century.

    PubMed

    Alexander, Amir R

    2006-12-01

    A new, Romantic type of mathematical story appeared in the early nineteenth century that was radically different from the sober narrative characteristic of the previous generation of mathematicians. At the same time, a new mathematical practice emerged that differed sharply from the understanding and practice of mathematics during the Enlightenment. These parallel developments are inseparable: the new type of mathematical practice went hand in hand with the new mathematical story.

  20. "El destierro de los Chinos": Popular Perspectives on Chinese-Mexican Intermarriage in the Early Twentieth Century

    ERIC Educational Resources Information Center

    Romero, Robert Chao

    2007-01-01

    This essay examines Chinese-Mexican interracial marriage during the early twentieth century through the lens of Mexican popular culture. Comedy, poetry, cartoons, and musical recordings of the time portrayed these marriages as relationships of abuse, slavery, and neglect, and rejected the offspring of such unions as subhuman and unworthy of full…

  1. Population pharmacokinetics of ticagrelor and AR-C124910XX in patients with prior myocardial infarction
.

    PubMed

    Röshammar, Daniel; Bergstrand, Martin; Andersson, Tomas; Storey, Robert F; Hamrén, Bengt

    2017-05-01

    The population pharmacokinetics of ticagrelor and its active metabolite AR-C124910XX were characterized following ticagrelor 60 mg or 90 mg twice daily oral long-term treatment in 4,426 patients with a history of myocardial infarction. The ticagrelor and AR-C124910XX plasma concentration-time data were described by one-compartment models with first-order absorption or metabolite formation and elimination. Systemic exposure to ticagrelor and AR-C124910XX were stable over time. Ticagrelor apparent clearance (CL/F) was 17 L/h for the 60-mg and 15.4 L/h for the 90-mg dose. The CL/F of AR-C124910XX was 11.1 L/h for the 60-mg and 9.95 L/h for the 90-mg dose. Both ticagrelor and AR-C124910XX CL/F were independently influenced by body weight, sex, age, smoking, and Japanese ethnicity. Female sex and age > 75 years were the only categorical covariates, having more than 20% effect on AR-C124910XX CL/F. Ticagrelor CL/F was 6% higher and 11% lower, whereas AR-C124910XX CL/F was 26% higher and 34% lower for patients weighing 110 and 50 kg, respectively, compared with an 83 kg patient. The small differences in exposure to both ticagrelor and AR-C124910XX between demographic subgroups were in accordance with the consistent efficacy and safety outcomes observed across the population. The results were similar to those observed previously in patients with acute coronary syndromes.
.

  2. Neptunism and Transformism: Robert Jameson and other Evolutionary Theorists in Early Nineteenth-Century Scotland.

    PubMed

    Jenkins, Bill

    2016-08-01

    This paper sheds new light on the prevalence of evolutionary ideas in Scotland in the early nineteenth century and establish what connections existed between the espousal of evolutionary theories and adherence to the directional history of the earth proposed by Abraham Gottlob Werner and his Scottish disciples. A possible connection between Wernerian geology and theories of the transmutation of species in Edinburgh in the period when Charles Darwin was a medical student in the city was suggested in an important 1991 paper by James Secord. This study aims to deepen our knowledge of this important episode in the history of evolutionary ideas and explore the relationship between these geological and evolutionary discourses. To do this it focuses on the circle of natural historians around Robert Jameson, Wernerian geologist and professor of natural history at the University of Edinburgh from 1804 to 1854. From the evidence gathered here there emerges a clear confirmation that the Wernerian model of geohistory facilitated the acceptance of evolutionary explanations of the history of life in early nineteenth-century Scotland. As Edinburgh was at this time the most important center of medical education in the English-speaking world, this almost certainly influenced the reception and development of evolutionary ideas in the decades that followed.

  3. 49 CFR 1242.59 - Train inspection and lubrication (account XX-51-62).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Train inspection and lubrication (account XX-51-62). 1242.59 Section 1242.59 Transportation Other Regulations Relating to Transportation (Continued) SURFACE...-Transportation § 1242.59 Train inspection and lubrication (account XX-51-62). Separate common expenses on basis...

  4. 49 CFR 1242.24 - Shop buildings-other equipment (account XX-19-26).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Shop buildings-other equipment (account XX-19-26). 1242.24 Section 1242.24 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.24 Shop buildings—other equipment (account XX-19-26). Assign directly to freight (or as...

  5. 49 CFR 1242.24 - Shop buildings-other equipment (account XX-19-26).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 9 2014-10-01 2014-10-01 false Shop buildings-other equipment (account XX-19-26). 1242.24 Section 1242.24 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.24 Shop buildings—other equipment (account XX-19-26). Assign directly to freight (or as...

  6. 49 CFR 1242.24 - Shop buildings-other equipment (account XX-19-26).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 9 2013-10-01 2013-10-01 false Shop buildings-other equipment (account XX-19-26). 1242.24 Section 1242.24 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.24 Shop buildings—other equipment (account XX-19-26). Assign directly to freight (or as...

  7. 49 CFR 1242.24 - Shop buildings-other equipment (account XX-19-26).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 9 2011-10-01 2011-10-01 false Shop buildings-other equipment (account XX-19-26). 1242.24 Section 1242.24 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.24 Shop buildings—other equipment (account XX-19-26). Assign directly to freight (or as...

  8. 49 CFR 1242.23 - Shop buildings-freight cars (account XX-13-25).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 9 2013-10-01 2013-10-01 false Shop buildings-freight cars (account XX-13-25). 1242.23 Section 1242.23 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.23 Shop buildings—freight cars (account XX-13-25). These accounts pertain solely to freight...

  9. 49 CFR 1242.24 - Shop buildings-other equipment (account XX-19-26).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 9 2012-10-01 2012-10-01 false Shop buildings-other equipment (account XX-19-26). 1242.24 Section 1242.24 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.24 Shop buildings—other equipment (account XX-19-26). Assign directly to freight (or as...

  10. 49 CFR 1242.23 - Shop buildings-freight cars (account XX-13-25).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Shop buildings-freight cars (account XX-13-25). 1242.23 Section 1242.23 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.23 Shop buildings—freight cars (account XX-13-25). These accounts pertain solely to freight...

  11. 49 CFR 1242.23 - Shop buildings-freight cars (account XX-13-25).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 9 2011-10-01 2011-10-01 false Shop buildings-freight cars (account XX-13-25). 1242.23 Section 1242.23 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.23 Shop buildings—freight cars (account XX-13-25). These accounts pertain solely to freight...

  12. 49 CFR 1242.23 - Shop buildings-freight cars (account XX-13-25).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 9 2014-10-01 2014-10-01 false Shop buildings-freight cars (account XX-13-25). 1242.23 Section 1242.23 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.23 Shop buildings—freight cars (account XX-13-25). These accounts pertain solely to freight...

  13. 49 CFR 1242.23 - Shop buildings-freight cars (account XX-13-25).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 9 2012-10-01 2012-10-01 false Shop buildings-freight cars (account XX-13-25). 1242.23 Section 1242.23 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.23 Shop buildings—freight cars (account XX-13-25). These accounts pertain solely to freight...

  14. Primary osteomyelofibrosis and an XX-male genotype.

    PubMed

    Schanz, Julie; Haase, Detlef; Steuernagel, Peter; Shirneshan, Katayoo; Bäsecke, Jörg

    2015-09-01

    A 62-yr-old man with two healthy daughters was diagnosed with osteomyelofibrosis. To our surprise, a female XX-karyotype was observed in bone marrow and confirmed in PHA-stimulated T-lymphocytes from peripheral blood. Further molecular genetic investigation revealed a submicroscopic translocation between the short arm of X and Y, which leads to an XX-male genotype based on an unbalanced translocation X;Y. This rare coincidence was further accentuated as the USP9Y gene, suspected to be to be involved in sperm cell production, was absent, but no azoospermia was present. In general, routine cytogenetics may result in findings that need to be further delineated and, as here, lead to a rare observation. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. MINDING THEIR OWN BUSINESS: MARRIED WOMEN AND CREDIT IN EARLY EIGHTEENTH-CENTURY LONDON.

    PubMed

    Shepard, Alexandra

    2015-12-01

    Taking a micro-historical approach, this paper explores the business activities of Elizabeth Carter and Elizabeth Hatchett, two married women who operated together as pawnbrokers in London in the early decades of the eighteenth century. Based on a protracted inheritance dispute through which their extensive dealings come to light, the discussion assesses married women's lending and investment strategies in a burgeoning metropolitan economy; the networks through which women lenders operated; and the extent to which wives could sidestep the legal conventions of 'coverture' which restricted their ownership of moveable property. It is argued that the moneylending and asset management activities of women like Carter and Hatchett were an important part of married women's work that did not simply consolidate neighbourhood ties but that placed them at the heart of the early modern economy.

  16. 49 CFR 1242.21 - Station and office buildings (account XX-19-23).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Station and office buildings (account XX-19-23). 1242.21 Section 1242.21 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Structures § 1242.21 Station and office buildings (account XX-19-23). If the sum of the direct freight and...

  17. The Regulation of Sox9 Gene Expression by the GATA4/FOG2 Transcriptional Complex in Dominant XX Sex Reversal Mouse Models.

    PubMed Central

    Manuylov, Nikolay L.; Fujiwara, Yuko; Adameyko, Igor I.; Poulat, Francis

    2007-01-01

    We have previously established an in vivo requirement for GATA4 and FOG2 transcription factors in sexual differentiation. Fog2 null mouse fetuses or fetuses homozygous for a targeted mutation in Gata4 (Gata4ki), which cripples the GATA4-FOG2 interaction, exhibit a profound and early block in testis differentiation in both sexes. Others have shown that XX mice with the Ods transgenic insertion or the Wt1-Sox9 YAC transgene overexpress the testis differentiation gene, Sox9. Thus, these XX animals undergo dominant sex-reversal by developing into phenotypically normal, but sterile, males. Now we have determined that Fog2 haploinsufficiency prevents (suppresses) this dominant sex-reversal and Fog2+/− Wt1-Sox9 or Ods XX animals develop normally - as fertile females. The suppression of sex-reversal in Fog2 heterozygous females results from approximately 50% downregulation of the expression from the transgene-associated allele of Sox9. The GATA4/FOG2-dependent sex reversal observed in the transgenic XX gonads has to rely on gene targets other than the Y chromosome-linked Sry gene. Importantly, Fog2 null or Gata4ki/ki embryos (either XX or XY) fail to express detectable levels of Sox9 despite carrying the Ods mutation or Wt1-Sox9 transgene. Fog2 haploinsufficiency leads to a decreased amount of SOX9-positive cells in XY gonads. We conclude that FOG2 is a limiting factor in the formation of a functional GATA4/FOG2 transcription complex that is required for Sox9 expression during gonadogenesis. PMID:17540364

  18. Comparison of growth-related traits and gene expression profiles between the offspring of neomale (XX) and normal male (XY) rainbow trout.

    PubMed

    Kocmarek, Andrea L; Ferguson, Moira M; Danzmann, Roy G

    2015-04-01

    All-female lines of fish are created by crossing sex reversed (XX genotype) males with normal females. All-female lines avoid the deleterious phenotypic effects that are typical of precocious maturation in males. To determine whether all-female and mixed sex populations of rainbow trout (Oncorhynchus mykiss) differ in performance, we compared the growth and gene expression profiles in progeny groups produced by crossing a XX male and a XY male to the same five females. Body weight and length were measured in the resulting all-female (XX) and mixed sex (XX/XY) offspring groups. Microarray experiments with liver and white muscle were used to determine if the gene expression profiles of large and small XX offspring differ from those in large and small XX/XY offspring. We detected no significant differences in body length and weight between offspring groups but XX offspring were significantly less variable in the value of these traits. A large number of upregulated genes were shared between the large XX and large XX/XY offspring; the small XX and small XX/XY offspring also shared similar expression profiles. No GO category differences were seen in the liver or between the large XX and large XX/XY offspring in the muscle. The greatest differences between the small XX and small XX/XY offspring were in the genes assigned to the "small molecule metabolic process" and "cellular metabolic process" GO level 3 categories. Similarly, genes within these categories as well as the category "macromolecule metabolic process" were more highly expressed in small compared to large XX fish.

  19. Resisting Conformity: Anglican Mission Women and the Schooling of Girls in Early Nineteenth-Century West Africa

    ERIC Educational Resources Information Center

    Leach, Fiona

    2012-01-01

    The origins of modern schooling in early nineteenth-century Africa have been poorly researched. Moreover, histories of education in Africa have focused largely on the education of boys. Little attention has been paid to girls' schooling or to the missionary women who sought to construct a new feminine Christian identity for African girls. In the…

  20. Excited state properties of naphtho-homologated xxDNA bases and effect of methanol solution, deoxyribose, and base pairing.

    PubMed

    Zhang, Laibin; Ren, Tingqi; Tian, Jianxiang; Yang, Xiuqin; Zhou, Liuzhu; Li, Xiaoming

    2013-04-18

    Design and synthesis of fluorescent nucleobase analogues for studying structures and dynamics of nucleic acids have attracted much attention in recent years. In the present work, a comprehensive theoretical study of electronic transitions of naphtho-homologated base analogues, namely, xxC, xxT, xxA, and xxG, was performed. The nature of the low-lying excited states was discussed, and the results were compared with those of x-bases. Geometrical characteristics of the lowest excited singlet ππ* states were explored using the CIS method. The calculated excitation maxima are 423, 397, 383, and 357 nm for xxA, xxG, xxC, and xxT, respectively, and they are greatly red-shifted compared with x-bases and natural bases, allowing them to be selectively excited in the presence of the natural bases. In the gas phase, the fluorescence from them would be expected to occur around 497, 461, 457, and 417 nm, respectively. The effects of methanol solution, deoxyribose, and base paring with their complementary natural bases on the relevant absorption and emission spectra of these modified bases were also examined.

  1. Cytogenetic analysis of somatic and germinal cells from 38,XX/38,XY phenotypically normal boars.

    PubMed

    Barasc, Harmonie; Ferchaud, Stéphane; Mary, Nicolas; Cucchi, Marie Adélaïde; Lucena, Amalia Naranjo; Letron, Isabelle Raymond; Calgaro, Anne; Bonnet, Nathalie; Dudez, Anne Marie; Yerle, Martine; Ducos, Alain; Pinton, Alain

    2014-01-15

    Many chromosomal abnormalities have been reported to date in pigs. Most of them have been balanced structural rearrangements, especially reciprocal translocations. A few cases of XY/XX chimerism have also been diagnosed within the national systematic chromosomal control program of young purebred boars carried out in France. Until now, this kind of chromosomal abnormality has been mainly reported in intersex individuals. We investigated 38,XY/38,XX boars presenting apparently normal phenotypes to evaluate the potential effects of this particular chromosomal constitution on their reproductive performance. To do this, we analyzed (1) the chromosomal constitution of cells from different organs in one boar; (2) the aneuploidy rates for chromosomes X, Y, and 13 in sperm nuclei sampled from seven XY/XX boars. 2n = 38,XX cells were identified in different nonhematopoietic tissues including testis (frequency, <8%). Similar aneuploidy rates were observed in the sperm nuclei of XY/XX and normal individuals (controls). Altogether, these results suggest that the presence of XX cells had no or only a very limited effect on the reproduction abilities of the analyzed boars. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. A Korean boy with 46,XX testicular disorder of sex development caused by SOX9 duplication.

    PubMed

    Lee, Gyung Min; Ko, Jung Min; Shin, Choong Ho; Yang, Sei Won

    2014-06-01

    The 46,XX testicular disorder of sex development (DSD), also known as 46,XX male syndrome, is a rare form of DSD and clinical phenotype shows complete sex reversal from female to male. The sex-determining region Y (SRY) gene can be identified in most 46,XX testicular DSD patients; however, approximately 20% of patients with 46,XX testicular DSD are SRY-negative. The SRY-box 9 (SOX9) gene has several important functions during testis development and differentiation in males, and overexpression of SOX9 leads to the male development of 46,XX gonads in the absence of SRY. In addition, SOX9 duplication has been found to be a rare cause of 46,XX testicular DSD in humans. Here, we report a 4.2-year-old SRY-negative 46,XX boy with complete sex reversal caused by SOX9 duplication for the first time in Korea. He showed normal external and internal male genitalia except for small testes. Fluorescence in situ hybridization and polymerase chain reaction (PCR) analyses failed to detect the presence of SRY, and SOX9 intragenic mutation was not identified by direct sequencing analysis. Therefore, we performed real-time PCR analyses with specific primer pairs, and duplication of the SOX9 gene was revealed. Although SRY-negative 46,XX testicular DSD is a rare condition, an effort to make an accurate diagnosis is important for the provision of proper genetic counseling and for guiding patients in their long-term management.

  3. Reading to the Soul: Narrative Imagery and Moral Education in Early to Mid-Twentieth-Century Queensland

    ERIC Educational Resources Information Center

    Carden, Clarissa

    2018-01-01

    This paper examines the way in which narratives, including stories and poetry, have been used in school texts relating to moral instruction. The paper will draw on texts used in Queensland classrooms in the early part of the twentieth century to demonstrate the ways in which description of sights and the experiences of the senses, and of…

  4. Immigration, Crime, and Incarceration in Early Twentieth-Century America

    PubMed Central

    MOEHLING, CAROLYN; PIEHL, ANNE MORRISON

    2009-01-01

    The major government commissions on immigration and crime in the early twentieth century relied on evidence that suffered from aggregation bias and the absence of accurate population data, which led them to present partial and sometimes misleading views of the immigrant-native criminality comparison. With improved data and methods, we find that in 1904, prison commitment rates for more serious crimes were quite similar by nativity for all ages except ages 18 and 19, for which the commitment rate for immigrants was higher than for the native-born. By 1930, immigrants were less likely than natives to be committed to prisons at all ages 20 and older, but this advantage disappears when one looks at commitments for violent offenses. The time series pattern reflects a growing gap between natives and immigrants at older ages, one that was driven by sharp increases in the commitment rates of the native-born, while commitment rates for the foreign-born were remarkably stable. PMID:20084827

  5. Immigration, crime, and incarceration in early twentieth-century America.

    PubMed

    Moehling, Carolyn; Piehl, Anne Morrison

    2009-11-01

    The major government commissions on immigration and crime in the early twentieth century relied on evidence that suffered from aggregation bias and the absence of accurate population data, which led them to present partial and sometimes misleading views of the immigrant-native criminality comparison. With improved data and methods, we find that in 1904, prison commitment rates for more serious crimes were quite similar by nativity for all ages except ages 18 and 19, for which the commitment rate for immigrants was higher than for the native-born. By 1930, immigrants were less likely than natives to be committed to prisons at all ages 20 and older, but this advantage disappears when one looks at commitments for violent offenses. The time series pattern reflects a growing gap between natives and immigrants at older ages, one that was driven by sharp increases in the commitment rates of the native-born, while commitment rates for the foreign-born were remarkably stable.

  6. Floods of the Maros river in the early modern and modern period (16th-20th centuries)

    NASA Astrophysics Data System (ADS)

    Kiss, Andrea

    2016-04-01

    In the poster presentation a series of historical and recent floods of the Maros river, with special emphasis on the flood events occurred on the lower sections, are presented. Similar to the Hungarian flood databases of the Middle-Danube and Lower-Tisza, the main sources of investigations are the institutional (legal-administrative) documentary evidence (e.g. Szeged and Makó town council protocols and related administrative documentation, Csanád County meeting protocols) mainly from the late 17th-early 18th century onwards. However, in case of the Maros river there is an increased importance of narrative sources, with special emphasis on the early modern period (16th-17th century): in this case the (mainly Transylvanian) narratives (chronicles, diaries, memoires etc.) written by aristocrats, other noblemen and town citizens have particular importance. In the presentation the frequency of detected flood events, from the mid-16th century onwards (with an outlook on sporadic medieval evidence), is provided; moreover, a 3-scaled magnitude classification and a seasonality analysis are also presented. Floods of the Maros river, especially those of the lower river sections, often cannot be understood and discussed without the floods of the (Lower-)Tisza; thus, a comparison of the two flood series are also a subject of discussion. Unlike the Lower-Tisza, the Maros is prone to winter and early spring ice jam floods: since the floods that belonged to this type (similar to those of the Middle-Danube at Budapest) were the most destructive among the flood events of the river, this flood type, and the greatest flood events (e.g. 1751-1752, 1784) are also presented in more detail.

  7. 49 CFR 1242.41 - Other and casualties and insurance (accounts XX-26-99 and 50-26-00).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Other and casualties and insurance (accounts XX-26... RAILROADS 1 Operating Expenses-Equipment § 1242.41 Other and casualties and insurance (accounts XX-26-99 and... administration (account XX-26-01). freight cars ...

  8. 49 CFR 1242.65 - Other and casualties and insurance (accounts XX-51-99 and 50-51-00).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Other and casualties and insurance (accounts XX-51... RAILROADS 1 Operating Expenses-Transportation § 1242.65 Other and casualties and insurance (accounts XX-51... separation of administration (account XX-51-01). yard operations ...

  9. Blockage of progestin physiology disrupts ovarian differentiation in XX Nile tilapia (Oreochromis niloticus).

    PubMed

    Zhou, Linyan; Luo, Feng; Fang, Xuelian; Charkraborty, Tapas; Wu, Limin; Wei, Jing; Wang, Deshou

    2016-04-22

    Previous studies indicated that maturation inducing hormone, 17α, 20β-Dihydroxy-4-pregnen-3-one (DHP), probably through nuclear progestin receptor (Pgr), might be involved in spermatogenesis and oogenesis in fish. To further elucidate DHP actions in teleostean ovarian differentiation, we analyzed the expression of pgr in the ovary of Nile tilapia (Oreochromis niloticus), and performed RU486 (a synthetic Pgr antagonist) treatment in XX fish from 5 days after hatching (dah) to 120 dah. Tilapia Pgr was abundantly expressed in the follicular cells surrounding oocytes at 30 and 90 dah. Continuous RU486 treatment led to the blockage of oogenesis and masculinization of somatic cells in XX fish. Termination of RU486 treatment and maintenance in normal condition resulted in testicular differentiation, and estrogen compensation in RU486-treated XX fish successfully restored oogenesis. In RU486-treated XX fish, transcript levels of female dominant genes were significantly reduced, while male-biased genes were evidently augmented. Meanwhile, both germ cell mitotic and meiotic markers were substantially reduced. Consistently, estrogen production levels were significantly declined in RU486-treated XX fish. Taken together, our data further proved that DHP, possibly through Pgr, might be essential in the ovarian differentiation and estrogen production in fish. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Monitoring Services to Children: Title XX

    ERIC Educational Resources Information Center

    Black Child Development Institute

    1977-01-01

    The proliferation of State offices of child development and the advent of Social Security Title XX funds have been accompanied by confusion at every level of government and in the black community. The impact of these developments on availability of good day care for children is examined and recommendations are made. (Author/AM)

  11. Providing In-Service Education at a Minimal Cost for Title XX Early Childhood Caregivers through a Conference, Workshop Series, and Networking.

    ERIC Educational Resources Information Center

    Miller, Susan Anderson

    Due to funding cutbacks resulting from the Title XX Social Services Block Grant, ongoing inservice education for teachers in the Berks County, Pennsylvania, Intermediate Unit Child Care Program had not been provided for over 2 years. To meet the need for inservice training, a practicum was designed and implemented to (1) increase inservice…

  12. 49 CFR 1242.45 - Passenger and other revenue equipment (account XX-27-45).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Passenger and other revenue equipment (account XX-27-45). 1242.45 Section 1242.45 Transportation Other Regulations Relating to Transportation... RAILROADS 1 Operating Expenses-Equipment § 1242.45 Passenger and other revenue equipment (account XX-27-45...

  13. The Lowland Rivers of The Netherlands - Geodiversity and Cultural Heritage on 19th and early 20th century Landscape Paintings

    NASA Astrophysics Data System (ADS)

    Jungerius, Pieter Dirk; van den Ancker, Hanneke; Moes, Constance

    2015-04-01

    One of the major Dutch landscapes is formed by lowland rivers. They divide the country in a southern and a northern part, both physically and culturally. We screened the freely available database of 19th and early 20th century paintings of Simonis & Buunk, www.simonis-buunk.com, looking for lowland river landscapes depicting geodiversity and cultural heritage relationships (See References for other landscapes). Emperor Napoleon declared The Netherlands as naturally belonging to his empire as its lands originated from muds originating in France and transported there by the big rivers. A description that may have given rise to the idea of the Netherlands as a delta, but from a geomorphological perspective The Netherlands consists of series of river plains of terrestrial origin, of which the north-western part are subsiding and invaded by the sea. Now, the rivers Meuse and Rhine (including its branches Waal and IJssel) meander through ever larger river plains before reaching the North Sea. They end in estuaries, something one would not expect of rivers with catchments discharging a large part of Western Europe. Apart from the geological subsidence, the estuaries might be due to human interference, the exploitation of peat and building of dikes since the 11th century, heavy storms and the strong tidal currents. Archaeological finds show Vikings and Romans already used the river Rhine system for trading and transporting goods. During the Roman Empire the Rhine was part of The Limes, the northern defence line of the empire. Romans already influenced the distribution of water over the different river branches. Since the middle of the 19th century groins and canalization drastically changed the character of the rivers. The 19th and early 20th century landscape paintings illustrate this change as well as changes in land use. Examples of geodiversity and cultural heritage relationships shown: - meanders and irregular banks disappear as river management increases, i.a. bends

  14. 49 CFR 1242.54 - Other and casualties and insurance (accounts XX-27-99 and 50-27-00).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Other and casualties and insurance (accounts XX-27... RAILROADS 1 Operating Expenses-Equipment § 1242.54 Other and casualties and insurance (accounts XX-27-99 and... administration (account XX-27-01). Operating Expenses—Transportation train operations ...

  15. 49 CFR 1242.82 - Other and casualties and insurance (accounts XX-55-99 and 50-55-00).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Other and casualties and insurance (accounts XX-55... RAILROADS 1 Operating Expenses-Transportation § 1242.82 Other and casualties and insurance (accounts XX-55... separation of administration (account XX-55-01). Operating Expenses general and administration ...

  16. 49 CFR 1242.72 - Other and casualties and insurance (accounts XX-52-99 and 50-52-00).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Other and casualties and insurance (accounts XX-52... RAILROADS 1 Operating Expenses-Transportation § 1242.72 Other and casualties and insurance (accounts XX-52... separation of administration (account XX-52-01). train and yard operations common ...

  17. Our Environment in Miniature: Dust and the Early Twentieth-Century Forensic Imagination

    PubMed Central

    BURNEY, IAN

    2013-01-01

    This article explores the articulation of the crime scene as a distinct space of theory and practice in the early twentieth century. In particular it focuses on the evidentiary hopes invested in what would at first seem an unpromising forensic object: dust. Ubiquitous and, to the uninitiated, characterless, dust nevertheless featured as an exemplary object of cutting-edge forensic analysis in two contemporary domains: writings of criminologists and works of detective fiction. The article considers how in these texts dust came to mark the furthest reach of a new forensic capacity they were promoting, one that drew freely upon the imagination to invest crime scene traces with meaning. PMID:23766552

  18. Figuring The Value of Literacy Education in the Late 19th and Early 20th Centuries.

    ERIC Educational Resources Information Center

    George, D'Ann

    As part of the research for a dissertation on composition at Bryn Mawr College during the late 19th and early 20th centuries, hundreds of student essays and daily themes were read. Over and over students affirmed the essential worth and significance of events in their daily lives and of their college education in general. More often than not,…

  19. Twentieth Century Thinkers in Adult & Continuing Education. Second Edition.

    ERIC Educational Resources Information Center

    Jarvis, Peter, Ed.

    This book contains 19 papers on 20th century thinkers in adult and continuing education. The book is arranged in four parts as follows: early 20th century English thinkers; early 20th century American thinkers; theorists of adult and continuing education; and theorists of adult education and social change. The following papers are included:…

  20. Early 20th century untrained nursing staff in the Rockhampton district: a necessary evil?

    PubMed

    Madsen, Wendy

    2005-08-01

    This paper explores the role of untrained nursing staff within the nursing services of the Rockhampton region, Queensland, Australia, throughout the early 20th century. It details who these nurses were, where they worked and how their work was affected by factors such as legislation and social changes. Despite the increasing prevalence of trained nurses from the late 19th century, nurses who had never undergone any formal training continued to gain work in hospitals, institutions and their local communities. This paper is an historical analysis of a wide range of primary source material relating to untrained nursing staff. The primary source material used related specifically to a limited geographical region in Australia. Untrained nursing staff primarily worked as private duty nurses at the beginning of the 20th century. However, as the century progressed, their opportunities to work as untrained nursing staff tended towards institutions dealing with the chronically ill and the aged. As a result of this transition, their profile altered from that of a married/widowed woman living at home with dependents to one who could live on-site at the institution with no dependents. Furthermore, the level of autonomy of the untrained nurse decreased dramatically throughout this period from being relatively independent to being under the control of a trained nurse within the institution. Consideration of the historical evolution of untrained nursing staff challenges some of the assumptions made about this category of nurse, assumptions that can affect current relationships between professional nurses and others who undertake nursing work.

  1. The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY.

    PubMed

    Sasidhar, Manda V; Itoh, Noriko; Gold, Stefan M; Lawson, Gregory W; Voskuhl, Rhonda R

    2012-08-01

    Many autoimmune diseases are characterised by a female predominance. This may be caused by sex hormones, sex chromosomes or both. This report uses a transgenic mouse model to investigate how sex chromosome complement, not confounded by differences in gonadal type, might contribute to lupus pathogenesis. Transgenic NZM2328 mice were created by deletion of the Sry gene from the Y chromosome, thereby separating genetic from gonadal sex. Survival, renal histopathology and markers of immune activation were compared in mice carrying the XX versus the XY(-) sex chromosome complement, with each genotype being ovary bearing. Mice with XX sex chromosome complement compared with XY(-) exhibited poorer survival rates and increased kidney pathology. Splenic T lymphocytes from XX mice demonstrated upregulated X-linked CD40 ligand expression and higher levels of activation markers ex vivo. Increased MMP, TGF and IL-13 production was found, while IL-2 was lower in XX mice. An accumulation of splenic follicular B cells and peritoneal marginal zone B cells was observed, coupled with upregulated costimulatory marker expression on B cells in XX mice. These data show that the XX sex chromosome complement, compared with XY(-), is associated with accelerated spontaneous lupus.

  2. Increased HDL cholesterol levels in mice with XX versus XY sex chromosomes

    PubMed Central

    Link, Jenny C.; Chen, Xuqi; Prien, Christopher; Borja, Mark S.; Hammerson, Bradley; Oda, Michael N.; Arnold, Arthur P.; Reue, Karen

    2015-01-01

    Objective The molecular mechanisms underlying sex differences in dyslipidemia are poorly understood. We aimed to distinguish genetic and hormonal regulators of sex differences in plasma lipid levels. Approach and Results We assessed the role of gonadal hormones and sex chromosome complement on lipid levels using the Four Core Genotypes mouse model (XX females, XX males, XY females, and XY males). In gonadally intact mice fed a chow diet, lipid levels were influenced by both male–female gonadal sex and XX–XY chromosome complement. Gonadectomy of adult mice revealed that the male–female differences are dependent on acute effects of gonadal hormones. In both intact and gonadectomized animals, XX mice had higher HDL cholesterol (HDL-C) levels than XY mice, regardless of male–female sex. Feeding a cholesterol-enriched diet produced distinct patterns of sex differences in lipid levels compared to a chow diet, revealing the interaction of gonadal and chromosomal sex with diet. Notably, under all dietary and gonadal conditions, HDL-C levels were higher in mice with two X chromosomes compared to mice with an X and Y chromosome. By generating mice with XX, XY and XXY chromosome complements, we determined that the presence of two X chromosomes, and not the absence of the Y chromosome, influences HDL-C concentration. Conclusions We demonstrate that having two X chromosomes versus an X and Y chromosome complement drives sex differences in HDL-C. It is conceivable that increased expression of genes escaping X-inactivation in XX mice regulates downstream processes to establish sexual dimorphism in plasma lipid levels. PMID:26112012

  3. Long-distance entanglement and quantum teleportation in XX spin chains

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Campos Venuti, L.; Giampaolo, S. M.; CNR-INFM Coherentia, Napoli

    2007-11-15

    Isotropic XX models of one-dimensional spin-1/2 chains are investigated with the aim to elucidate the formal structure and the physical properties that allow these systems to act as channels for long-distance, high-fidelity quantum teleportation. We introduce two types of models: (i) open, dimerized XX chains, and (ii) open XX chains with small end bonds. For both models we obtain the exact expressions for the end-to-end correlations and the scaling of the energy gap with the length of the chain. We determine the end-to-end concurrence and show that model (i) supports true long-distance entanglement at zero temperature, while model (ii) supportsmore » 'quasi-long-distance' entanglement that slowly falls off with the size of the chain. Due to the different scalings of the gaps, respectively exponential for model (i) and algebraic in model (ii), we demonstrate that the latter allows for efficient qubit teleportation with high fidelity in sufficiently long chains even at moderately low temperatures.« less

  4. Useful Citizens, Useful Citizenship: Cultural Contexts of Sámi Education in Early Twentieth-Century Norway, Sweden, and Finland

    ERIC Educational Resources Information Center

    Kortekangas, Otso

    2017-01-01

    This article investigates Sámi elementary education in early twentieth-century Finland, Norway, and Sweden. The main focus lies on cultural contexts that frame and limit language use. The key analytical concepts are "useful citizen" and "useful citizenship". Through these concepts the article probes the ways in which…

  5. Increased high-density lipoprotein cholesterol levels in mice with XX versus XY sex chromosomes.

    PubMed

    Link, Jenny C; Chen, Xuqi; Prien, Christopher; Borja, Mark S; Hammerson, Bradley; Oda, Michael N; Arnold, Arthur P; Reue, Karen

    2015-08-01

    The molecular mechanisms underlying sex differences in dyslipidemia are poorly understood. We aimed to distinguish genetic and hormonal regulators of sex differences in plasma lipid levels. We assessed the role of gonadal hormones and sex chromosome complement on lipid levels using the four core genotypes mouse model (XX females, XX males, XY females, and XY males). In gonadally intact mice fed a chow diet, lipid levels were influenced by both male-female gonadal sex and XX-XY chromosome complement. Gonadectomy of adult mice revealed that the male-female differences are dependent on acute effects of gonadal hormones. In both intact and gonadectomized animals, XX mice had higher HDL cholesterol (HDL-C) levels than XY mice, regardless of male-female sex. Feeding a cholesterol-enriched diet produced distinct patterns of sex differences in lipid levels compared with a chow diet, revealing the interaction of gonadal and chromosomal sex with diet. Notably, under all dietary and gonadal conditions, HDL-C levels were higher in mice with 2 X chromosomes compared with mice with an X and Y chromosome. By generating mice with XX, XY, and XXY chromosome complements, we determined that the presence of 2 X chromosomes, and not the absence of the Y chromosome, influences HDL-C concentration. We demonstrate that having 2 X chromosomes versus an X and Y chromosome complement drives sex differences in HDL-C. It is conceivable that increased expression of genes escaping X-inactivation in XX mice regulates downstream processes to establish sexual dimorphism in plasma lipid levels. © 2015 American Heart Association, Inc.

  6. 49 CFR 1242.74 - Adjusting and transferring loads, and car loading devices and grain doors (accounts XX-33-71 and...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Adjusting and transferring loads, and car loading devices and grain doors (accounts XX-33-71 and XX-33-72). 1242.74 Section 1242.74 Transportation Other... loads, and car loading devices and grain doors (accounts XX-33-71 and XX-33-72). These accounts pertain...

  7. First Annual Report to Congress on Title XX of the Social Security Act.

    ERIC Educational Resources Information Center

    Department of Health, Education, and Welfare, Washington, DC.

    This annual report to Congress on Title XX of the Social Security Act reports on the operation of the 1976 fiscal year program. Preceding the report are descriptive highlights of the program. Title XX of the Social Security Act changes the role and relationships of the Department of Health, Education, and Welfare; the individual states; and…

  8. [The Library of Medicine of Córdoba, witness and protagonist of knowledge from the end of the 19th Century to the beginning of 21st Century].

    PubMed

    Graciela Cañete, M

    2004-01-01

    In the nineteenth century, was founded the Medicine's Library of the National University Faculty of Medicine, center of knowledge, new ideas and teaching. The history library sector hold the valuable inheritance that represent the collection of Teachers Doctors, Pablo Mirizzi, Temístocles Castellano, Pedro Ara, José F. Verna, Juan Martín Allende located with the books and thesis of the XIX century and beginning of XX century. In 1986 it integrates the National Health Science Information Network and also, the Latino American and the Caribbean Health Science Information Network. The health libraries are in front of a new paradigm. The technologies of information and communication require new methods for administration of the information's resources and services, to answer the society information needs in the knowledge age. The traditional and virtual library is one unit that complement sources in different supports, electronic publications and interactive networks. It is the nexus between the scientific inheritance and the society, and it's mission is: Give local and virtual information's services and management the information's resources, basis of the knowledge society, support of teaching, investigation and extension of the Medical Sciences Faculty of the Córdoba National University.

  9. Young patients in a young nation: scarlet fever in early nineteenth century rural New England.

    PubMed

    Radikas, Regina; Connolly, Cindy

    2007-01-01

    Children in the United States have benefited considerably from advancements in medical and nursing science over the course of the past 200 years. The twentieth century saw dramatic declines in the incidence of childhood diseases; the prevalence of measles, haemophilus influenzae type B, diphtheria, rubella and tetanus are at all time lows (CDC, 2006). Indeed, many pediatric nurses have never seen any of these diseases, something that would certainly have startled their predecessors just a few generations ago. Before the mid- twentieth century, caring for children with communicable diseases represented the cornerstone of pediatric nursing practice. Now that the incidence has decreased among American children, it is easy to forget about these diseases that once decimated whole communities. This article tries to peel back the mists of history by studying children's health in one rural New England town during the days of the early republic in the 1830s.

  10. The first case of 38,XX (SRY-positive) disorder of sex development in a cat.

    PubMed

    Szczerbal, Izabela; Stachowiak, Monika; Dzimira, Stanislaw; Sliwa, Krystyna; Switonski, Marek

    2015-01-01

    SRY-positive XX testicular disorder of sex development (DSD) caused by X;Y translocations was not yet reported in domestic animals. In humans it is rarely diagnosed and a majority of clinical features resemble those which are typical for Klinefelter syndrome (KS). Here we describe the first case of SRY-positive XX DSD in a tortoiseshell cat with a rudimentary penis and a lack of scrotum. Molecular analysis showed the presence of two Y-linked genes (SRY and ZFY) and a normal sequence of the SRY gene. Application of classical cytogenetic techniques revealed two X chromosomes (38,XX), but further FISH studies with the use of the whole X chromosome painting probe and BAC probes specific to the Yp chromosome facilitated identification of Xp;Yp translocation. The SRY gene was localised at a distal position of Xp. The karyotype of the studied case was described as: 38,XX.ish der(X)t(X;Y)(p22;p12)(SRY+). Moreover, the X inactivation status assessed by a sequential R-banding and FISH with the SRY-specific probe showed a random inactivation of the derivative X(SRY) chromosome. Our study showed that among DSD tortoiseshell cats, apart from XXY trisomy and XX/XY chimerism, also SRY-positive XX cases may occur. It is hypothesized that the extremely rare occurrence of this abnormality in domestic animals, when compared with humans, may be associated with a different organisation of the Yp arm in these species.

  11. Disorders of Sex Development with Testicular Differentiation in SRY-Negative 46,XX Individuals: Clinical and Genetic Aspects.

    PubMed

    Grinspon, Romina P; Rey, Rodolfo A

    2016-01-01

    Virilisation of the XX foetus is the result of androgen excess, resulting most frequently from congenital adrenal hyperplasia in individuals with typical ovarian differentiation. In rare cases, 46,XX gonads may differentiate into testes, a condition known as 46,XX testicular disorders of sex development (DSD), or give rise to the coexistence of ovarian and testicular tissue, a condition known as 46,XX ovotesticular DSD. Testicular tissue differentiation may be due to the translocation of SRY to the X chromosome or an autosome. In the absence of SRY, overexpression of other pro-testis genes, e.g. SOX family genes, or failure of pro-ovarian/anti-testis genes, such as WNT4 and RSPO1, may underlie the development of testicular tissue. Recent experimental and clinical evidence giving insight into SRY-negative 46,XX testicular or ovotesticular DSD is discussed. © 2016 S. Karger AG, Basel.

  12. Birth Attendants and Midwifery Practice in Early Twentieth-century Derbyshire

    PubMed Central

    Reid, Alice

    2012-01-01

    Summary The 1902 Midwives Act introduced training and supervision for midwives in England and Wales, outlawing uncertified-and-untrained midwives (handywomen) and phasing out certified-but-untrained (bona fide) midwives. This paper compares the numbers and practices of these two different types of birth attendant with each other, with qualified and certified midwives and with doctors in early twentieth-century Derbyshire during this period of change, and examines the spatial and social factors influencing women's choice of birth attendant. It finds that the new legislation did not entirely eliminate continuity in traditional practices and allegiance, and that both social and spatial factors governed the choice of delivery attendant, with fewer midwives available in rural areas and a surviving network of untrained bona fide midwives in mining communities. Within this spatial pattern, however, although wealthier women were more likely to have chosen a doctor or a qualified midwife, familiarity and loyalty allowed bona fide midwives to maintain their case loads.

  13. A mutation in the nucleoporin-107 gene causes XX gonadal dysgenesis.

    PubMed

    Weinberg-Shukron, Ariella; Renbaum, Paul; Kalifa, Rachel; Zeligson, Sharon; Ben-Neriah, Ziva; Dreifuss, Amatzia; Abu-Rayyan, Amal; Maatuk, Noa; Fardian, Nilly; Rekler, Dina; Kanaan, Moien; Samson, Abraham O; Levy-Lahad, Ephrat; Gerlitz, Offer; Zangen, David

    2015-11-02

    Ovarian development and maintenance are poorly understood; however, diseases that affect these processes can offer insights into the underlying mechanisms. XX female gonadal dysgenesis (XX-GD) is a rare, genetically heterogeneous disorder that is characterized by underdeveloped, dysfunctional ovaries, with subsequent lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism. Here, we report an extended consanguineous family of Palestinian origin, in which 4 females exhibited XX-GD. Using homozygosity mapping and whole-exome sequencing, we identified a recessive missense mutation in nucleoporin-107 (NUP107, c.1339G>A, p.D447N). This mutation segregated with the XX-GD phenotype and was not present in available databases or in 150 healthy ethnically matched controls. NUP107 is a component of the nuclear pore complex, and the NUP107-associated protein SEH1 is required for oogenesis in Drosophila. In Drosophila, Nup107 knockdown in somatic gonadal cells resulted in female sterility, whereas males were fully fertile. Transgenic rescue of Drosophila females bearing the Nup107D364N mutation, which corresponds to the human NUP107 (p.D447N), resulted in almost complete sterility, with a marked reduction in progeny, morphologically aberrant eggshells, and disintegrating egg chambers, indicating defective oogenesis. These results indicate a pivotal role for NUP107 in ovarian development and suggest that nucleoporin defects may play a role in milder and more common conditions such as premature ovarian failure.

  14. The Democratic School and the Pedagogy of Janusz Korczak: A Model of Early Twentieth Century Reform in Modern Israel

    ERIC Educational Resources Information Center

    Engel, Liba H.

    2013-01-01

    This article explores the history and pedagogy of Janusz Korczak within the context of his contemporary early Twentieth-Century European Innovative Educators which include Maria Montessori, Homer Lane, A.S. Neill, and Anton Semyonovitch Makarenko. The pedagogies of the aforementioned are compared and contrasted within the literature.

  15. Missing the Boat with Technology Usage in Early Childhood Settings: A 21st Century View of Developmentally Appropriate Practice

    ERIC Educational Resources Information Center

    Parette, Howard P.; Quesenberry, Amanda C.; Blum, Craig

    2010-01-01

    Technology use permeates virtually all aspects of twenty-first century society, though its integration in early childhood settings and recognition as a developmentally appropriate practice remains problematic. A position is taken that education professionals may be "missing the boat" by not embracing technology usage as a developmentally…

  16. XY females do better than the XX in the African pygmy mouse, Mus minutoides.

    PubMed

    Saunders, Paul A; Perez, Julie; Rahmoun, Massilva; Ronce, Ophélie; Crochet, Pierre-André; Veyrunes, Frédéric

    2014-07-01

    All therian mammals have a similar XY/XX sex-determination system except for a dozen species. The African pygmy mouse, Mus minutoides, harbors an unconventional system in which all males are XY, and there are three types of females: the usual XX but also XX* and X*Y ones (the asterisk designates a sex-reversal mutation on the X chromosome). The long-term evolution of such a system is a paradox, because X*Y females are expected to face high reproductive costs (e.g., meiotic disruption and loss of unviable YY embryos), which should prevent invasion and maintenance of a sex-reversal mutation. Hence, mechanisms for compensating for the costs could have evolved in M. minutoides. Data gathered from our laboratory colony revealed that X*Y females do compensate and even show enhanced reproductive performance in comparison to the XX and XX*; they produce significantly more offspring due to (i) a higher probability of breeding, (ii) an earlier first litter, and (iii) a larger litter size, linked to (iv) a greater ovulation rate. These findings confirm that rare conditions are needed for an atypical sex-determination mechanism to evolve in mammals, and provide valuable insight into understanding modifications of systems with highly heteromorphic sex chromosomes. © 2014 The Author(s). Evolution © 2014 The Society for the Study of Evolution.

  17. A Non-Reciprocal Autosomal Translocation 64,XX, t(4;10)(q21;p15) in an Arabian Mare with Repeated Early Embryonic Loss.

    PubMed

    Ghosh, S; Das, P J; Avila, F; Thwaits, B K; Chowdhary, B P; Raudsepp, T

    2016-02-01

    Balanced autosomal translocations are a known cause for repeated early embryonic loss (REEL) in horses. In most cases, carriers of such translocations are phenotypically normal, but the chromosomal aberration negatively affects gametogenesis giving rise to both genetically balanced and unbalanced gametes. The latter, if involved in fertilization, result in REEL, whereas gametes with the balanced form of translocation will pass the defect into next generation. Therefore, in order to reduce the incidence of REEL, identification of translocation carriers is critical. Here, we report about a phenotypically normal 3-year-old Arabian mare that had repeated resorption of conceptuses prior to day 45 of gestation and was diagnosed with REEL. Conventional and molecular cytogenetic analyses revealed that the mare had normal chromosome number 64,XX but carried a non-mosaic and non-reciprocal autosomal translocation t(4;10)(q21;p15). This is a novel translocation described in horses with REEL and the first such report in Arabians. Previous cases of REEL due to autosomal translocations have exclusively involved Thoroughbreds. The findings underscore the importance of routine cytogenetic screening of breeding animals. © 2015 Blackwell Verlag GmbH.

  18. [Analysis of clinical features and related genes variation in five patients with 46, XX male syndrome].

    PubMed

    Qin, X Y; Dong, W K; Wang, W; Dong, Z Y; Xiao, Y; Lu, W L; Wang, D F

    2016-11-02

    Objective: To explore the clinical manifestations and molecular features of 46, XX male syndrome. Method: The clinical and molecular data of five 46, XX male syndrome cases treated in the Department of Pediatrics of Shanghai Ruijin Hospital form August 2010 to August 2014 were retrospectively analyzed. Result: The five patients were all sociopsychologically males and came to hospital respectively for short stature, ambiguous genitalia or gynecomastia. They were all below the normal male's average height, and their karyotype was all 46, XX. One case in five was verified as sex determining region of Y chromosome (SRY gene) positive revealed no abnormality in their external genitalia. He had short stature since childhood, whose SRY gene fragments were shown by FISH transferred to the ends of X chromosome. Three cases in four were SRY gene negative with ambiguous genitalia of cryptorchidism and testicular dysplasia to different degrees. The copy number variations of SOX9 gene was found in one case, the loss of heterozygosity area in DHH gene of one case. Another SRY gene negative patient who had normal male external genitalia, came to the hospital due to puberty gynecomastia, that of SOX9 gene and its upstream gene both increased. Conclusion: The main clinical characteristics of 46, XX male syndrome are male phenotype, 46, XX karyotype, gonad of testis or ovotestis and no uterus. In addition, short stature, ambiguous genitalia or gynecomastia can be one reason for hospital visits. SRY gene translocation, SOX9 gene and its upstream gene copy number increase all can lead to 46, XX male syndrome. The cause of some may play an important role in 46, XX male syndrome, but has not yet been determined.

  19. Coexistence of Trisomy 13 and SRY (-) XX Ovotesticular Disorder of Sex Development.

    PubMed

    Ürel Demir, Gizem; Doğan, Özlem Akgün; Şimşek Kiper, Pelin Özlem; Utine, Gülen Eda; Boduroğlu, Koray; Gucer, Safak; Alikaşifoğlu, Mehmet

    2017-12-01

    Ovotesticular disorder of sex development (OT-DSD) is a rare disorder of sexual differentiation characterized by the presence of both testicular and ovarian tissue in an individual and the majority of cases have been reported with 46,XX karyotype. In 46,XX cases, testicular differentiation may occur due to the translocation of SRY to the X chromosome or to an autosome. Herein, we present a female newborn with a combination of trisomy 13 and SRY (-) XX OT-DSD. Trisomy 13 is a relatively common and well-known chromosomal disorder in which disorders of sexual differentiation are not frequent. In the absence of SRY, overexpression of pro-testis genes, or decreased expression of pro-ovarian/anti-testis genes have been suggested as underlying mechanisms of testicular formation. The findings in this patient were suggestive of an underlying genomic disorder associated with FGF9 and/or SPRY2.

  20. Priestley's Shadow and Lavoisier's Influence: Electricity and Heat in the Late Eighteenth and Early Nineteenth Centuries

    NASA Astrophysics Data System (ADS)

    Fisher, Amy

    In the late eighteenth century, Joseph Priestley argued that any complete theory of heat also had to explain electrical phenomena, which manifested many similar effects to heat. For example, sparking or heating a sample of trapped air caused a reduction in the volume of air and made the gas toxic to living organisms. Because of the complexity of electrical and thermal phenomena, Antoine Lavoisier did not address electrical action in his published works. Rather, he focused on those effects produced by heating alone. With the success of Lavoisier's caloric theory of heat, natural philosophers and chemists continued to debate the relationship between heat and electricity. In this presentation, I compare and contrast the fate of caloric in early-nineteenth-century electrical studies via the work of two scientists: Humphry Davy in Britain and Robert Hare in America.

  1. Representations of Technology in the "Technical Stories" for Children of Otto Witt, Early 20th Century Swedish Technology Educator

    ERIC Educational Resources Information Center

    Axell, Cecilia; Hallström, Jonas

    2013-01-01

    Children's fiction in school libraries have played and still play a role in mediating representations of technology and attitudes towards technology to schoolchildren. In early 20th century Sweden, elementary education, including textbooks and literature that were used in teaching, accounted for the main mediation of technological knowledge to…

  2. A Case With Short Stature, Growth Hormone Deficiency and 46, XX, Xq27-qter Deletion.

    PubMed

    Yıldırım, Şule; Topaloğlu, Naci; Tekin, Mustafa; Sılan, Fatma

    2017-10-01

    We report a case of 11-year-old girl with growth retardation and 46, XX, Xq27-qter deletion. The endocrinologic evaluation revealed growth hormone deficiency. In karyotype analysis  46, XX, Xq27-qter deletion was determined. The deletion of terminal region of chromosome 27 is most commonly being detected during the evaluation of infertility, premature ovarian insufficiency or in screening for fragile X carrier status. To our knowledge, this is the first reported case with 46, XX, Xq27-qter deletion and growth hormone deficiency. Furthermore, this case might facilitate future search for candidate genes involved in growth hormone deficiency.

  3. 46 XX karyotype during male fertility evaluation; case series and literature review

    PubMed Central

    Majzoub, Ahmad; Arafa, Mohamed; Starks, Christopher; Elbardisi, Haitham; Al Said, Sami; Sabanegh, Edmund

    2017-01-01

    Forty-six XX disorder of sex development is an uncommon medical condition observed at times during the evaluation of a man's fertility. The following is a case series and literature review of phenotypically normal men diagnosed with this karyotype. Our goal is to comprehend the patients’ clinical presentation as well as their laboratory results aiming to explore options available for their management. A formal literature review through PubMed and MEDLINE databases was performed using “46 XX man” as a word search. A total of 55 patients, including those conveyed in this article were diagnosed with a 46 XX karyotype during their fertility evaluation. The patients’ mean age ± s.d. was 34 ± 10 years and their mean height ± s.d. was 166 ± 6.5 cm. Overall, they presented with hypergonadotropic hypogonadism. Sexual dysfunction, reduced hair distribution, and gynecomastia were reported in 20% (4/20), 25.8% (8/31), and 42% (13/31) of the patients, respectively. The SRY gene was detected in 36 (83.7%) and was absent in the remaining seven (16.3%) patients. We found that a multidisciplinary approach to management is preferred in 46 XX patients. Screening for remnants of the mullerian ducts and for malignant transformation in dysgenetic gonads is imperative. Hypogonadism should be addressed, while fertility options are in vitro fertilization with donor sperm or adoption. PMID:27297128

  4. 46 XX karyotype during male fertility evaluation; case series and literature review.

    PubMed

    Majzoub, Ahmad; Arafa, Mohamed; Starks, Christopher; Elbardisi, Haitham; Al Said, Sami; Sabanegh, Edmund

    2017-01-01

    Forty-six XX disorder of sex development is an uncommon medical condition observed at times during the evaluation of a man's fertility. The following is a case series and literature review of phenotypically normal men diagnosed with this karyotype. Our goal is to comprehend the patients' clinical presentation as well as their laboratory results aiming to explore options available for their management. A formal literature review through PubMed and MEDLINE databases was performed using "46 XX man" as a word search. A total of 55 patients, including those conveyed in this article were diagnosed with a 46 XX karyotype during their fertility evaluation. The patients' mean age ± s.d. was 34 ± 10 years and their mean height ± s.d. was 166 ± 6.5 cm. Overall, they presented with hypergonadotropic hypogonadism. Sexual dysfunction, reduced hair distribution, and gynecomastia were reported in 20% (4/20), 25.8% (8/31), and 42% (13/31) of the patients, respectively. The SRY gene was detected in 36 (83.7%) and was absent in the remaining seven (16.3%) patients. We found that a multidisciplinary approach to management is preferred in 46 XX patients. Screening for remnants of the mullerian ducts and for malignant transformation in dysgenetic gonads is imperative. Hypogonadism should be addressed, while fertility options are in vitro fertilization with donor sperm or adoption.

  5. A rare case of 46,XX gonadal dysgenesis and Mayer-Rokitansky-Kuster-Hauser syndrome.

    PubMed

    Manne, Sriharibabu; Veeraabhinav, C H; Jetti, Mounica; Himabindu, Yalamanchali; Donthu, Kiranmai; Badireddy, Mutyalarayudu

    2016-01-01

    46,XX gonadal dysgenesis is a rare genetically heterogeneous disorder characterized by underdeveloped ovaries with consequent, impuberism, primary amenorrhea, and hypergonadotropic hypogonadism. Mullerian agenesis or Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and the upper part (2/3) of the vagina in a woman with normal development of secondary sexual characteristics and a normal 46,XX karyotype. The phenotypic manifestations of MRKH syndrome may sometimes overlap with various other syndromes and require accurate delineation. The coexistence of both these disorders is extremely rare. Here, we report a case of 46,XX gonadal dysgenesis and MRKH syndrome with anatomically dispersed congenital anomalies unique among reported cases.

  6. Reliability of 46,XX results on miscarriage specimens: a review of 1,222 first-trimester miscarriage specimens.

    PubMed

    Lathi, Ruth B; Gustin, Stephanie L F; Keller, Jennifer; Maisenbacher, Melissa K; Sigurjonsson, Styrmir; Tao, Rosina; Demko, Zach

    2014-01-01

    To examine the rate of maternal contamination in miscarriage specimens. Retrospective review of 1,222 miscarriage specimens submitted for chromosome testing with detection of maternal cell contamination (MCC). Referral centers requesting genetic testing of miscarriage specimens at a single reference laboratory. Women with pregnancy loss who desire complete chromosome analysis of the pregnancy tissue. Analysis of miscarriage specimens using single-nucleotide polymorphism (SNP) microarray technology with bioinformatics program to detect maternal cell contamination. Chromosome content of miscarriages and incidence of 46,XX results due to MCC. Of the 1,222 samples analyzed, 592 had numeric chromosomal abnormalities, and 630 were normal 46,XX or 46,XY (456 and 187, respectively). In 269 of the 46,XX specimens, MCC with no embryonic component was found. With the exclusion of maternal 46,XX results, the chromosomal abnormality rate increased from 48% to 62%, and the ratio for XX to XY results dropped from 2.6 to 1.0. Over half of the normal 46,XX results in miscarriage specimens were due to MCC. The use of SNPs in MCC testing allows for precise identification of chromosomal abnormalities in miscarriage as well as MCC, improving the accuracy of products of conception testing. Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  7. Robert Hare's Theory of Galvanism: A Study of Heat and Electricity in Early Nineteenth-Century American Chemistry.

    PubMed

    Fisher, Amy

    2018-04-09

    As a professor of chemistry at the University of Pennsylvania, Robert Hare actively shaped early American science. He participated in a large network of scholars, including Joseph Henry, François Arago, and Jacob Berzelius, and experimented with and wrote extensively about electricity and its associated chemical and thermal phenomena. In the early nineteenth century, prominent chemists such as Berzelius and Humphry Davy proclaimed that a revolution had occurred in chemistry through electrical research. Examining Robert Hare's contributions to this discourse, this paper analyzes how Hare's study of electricity and the caloric theory of heat led him to propose a new theory of galvanism. It also examines the reception of Hare's work in America and Great Britain, highlighting the contributions of early American chemists to the development of electrochemistry.

  8. Services to Status Offenders and Delinquents under Title XX.

    ERIC Educational Resources Information Center

    Nelson, Gary M.

    1982-01-01

    Found that states prohibiting institutionalization of status offenders and juvenile delinquents were no more likely to provide high levels of child foster care and protective services under Title XX than states not prohibiting institutionalization. (Author)

  9. Molecular mechanisms associated with 46,XX disorders of sex development.

    PubMed

    Knarston, Ingrid; Ayers, Katie; Sinclair, Andrew

    2016-03-01

    In the female gonad, distinct signalling pathways activate ovarian differentiation while repressing the formation of testes. Human disorders of sex development (DSDs), such as 46,XX DSDs, can arise when this signalling is aberrant. Here we review the current understanding of the genetic mechanisms that control gonadal development, with particular emphasis on those that drive or inhibit ovarian differentiation. We discuss how disruption to these molecular pathways can lead to 46,XX disorders of ovarian development. Finally, we look at recently characterized novel genes and pathways that contribute and speculate how advances in technology will aid in further characterization of normal and disrupted human ovarian development. © 2016 Authors; published by Portland Press Limited.

  10. A fiber-coupled 9xx module with tap water cooling

    NASA Astrophysics Data System (ADS)

    Schleuning, D.; Anthon, D.; Chryssis, A.; Ryu, G.; Liu, G.; Winhold, H.; Fan, L.; Xu, Z.; Tanbun-Ek, T.; Lehkonen, S.; Acklin, B.

    2016-03-01

    A novel, 9XX nm fiber-coupled module using arrays of highly reliable laser diode bars has been developed. The module is capable of multi-kW output power in a beam parameter product of 80 mm-mrad. The module incorporates a hard-soldered, isolated stack package compatible with tap-water cooling. Using extensive, accelerated multi-cell life-testing, with more than ten million device hours of test, we have demonstrated a MTTF for emitters of >500,000 hrs. In addition we have qualified the module in hard-pulse on-off cycling and stringent environmental tests. Finally we have demonstrated promising results for a next generation 9xx nm chip design currently in applications and qualification testing

  11. High temperature increases the masculinization rate of the all-female (XX) rainbow trout "Mal" population.

    PubMed

    Valdivia, Karina; Jouanno, Elodie; Volff, Jean-Nicolas; Galiana-Arnoux, Delphine; Guyomard, René; Helary, Louise; Mourot, Brigitte; Fostier, Alexis; Quillet, Edwige; Guiguen, Yann

    2014-01-01

    Salmonids are generally considered to have a robust genetic sex determination system with a simple male heterogamety (XX/XY). However, spontaneous masculinization of XX females has been found in a rainbow trout population of gynogenetic doubled haploid individuals. The analysis of this masculinization phenotype transmission supported the hypothesis of the involvement of a recessive mutation (termed mal). As temperature effect on sex differentiation has been reported in some salmonid species, in this study we investigated in detail the potential implication of temperature on masculinization in this XX mal-carrying population. Seven families issued from XX mal-carrying parents were exposed from the time of hatching to different rearing water temperatures ((8, 12 and 18°C), and the resulting sex-ratios were confirmed by histological analysis of both gonads. Our results demonstrate that masculinization rates are strongly increased (up to nearly two fold) at the highest temperature treatment (18°C). Interestingly, we also found clear differences between temperatures on the masculinization of the left versus the right gonads with the right gonad consistently more often masculinized than the left one at lower temperatures (8 and 12°C). However, the masculinization rate is also strongly dependent on the genetic background of the XX mal-carrying families. Thus, masculinization in XX mal-carrying rainbow trout is potentially triggered by an interaction between the temperature treatment and a complex genetic background potentially involving some part of the genetic sex differentiation regulatory cascade along with some minor sex-influencing loci. These results indicate that despite its rather strict genetic sex determinism system, rainbow trout sex differentiation can be modulated by temperature, as described in many other fish species.

  12. Ten cases with 46,XX testicular disorder of sex development: single center experience.

    PubMed

    Akinsal, Emre Can; Baydilli, Numan; Demirtas, Abdullah; Saatci, Cetin; Ekmekcioglu, Oguz

    2017-01-01

    To present clinical, chromosomal and hormonal features of ten cases with SRY-positive 46,XX testicular disorder of sex development who were admitted to our infertility clinic. Records of the cases who were admitted to our infertility clinic between 2004 and 2015 were investigated. Ten 46,XX testicular disorder of sex development cases were detected. Clinical, hormonal and chromosomal assessments were analized. Mean age at diagnosis was 30.4, mean body height was 166.9cm. Hormonal data indicated that the patients had a higher FSH, LH levels, lower TT level and normal E2, PRL levels. Karyotype analysis of all patients confirmed 46,XX karyotype, and FISH analysis showed that SRY gene was positive and translocated to Xp. The AZFa, AZFb and AZFc regions were absent in 8 cases. In one case AZFb and AZFc incomplete deletion and normal AZFa region was present. In the other one all AZF regions were present. Gonadal development disorders such as SRY-positive 46,XX testicular disorder of sex development can be diagnosed in infertility clinics during infertility workup. Although these cases had no chance of bearing a child, they should be protected from negative effects of testosterone deficiency by replacement therapies. Copyright® by the International Brazilian Journal of Urology.

  13. Public health and social supervision issues within public administration of ukrainian territories in the late 8th- early 9th centuries.

    PubMed

    Hrynzovskyi, Anatolii M; Holovanova, Irina A; Omelchuk, Sergei T; Kuzminska, Olena V; Hrynzovska, Anastasia A; Karlova, Olena O; Kondratiuk, Vitalii Ye

    Introduction: The public health system modernization history is based upon the progress in state country administration and administration of healthcare within the sectorwide approach. The WHO European Bureau pays much attention to the National Health Service systems development while implementing their basic policies. The Ukrainian state health service management was founded basing on the regulatory field of the Russian Empire, using the European healthcare promotion experience. Aim: of the article is the analysis of the regulatory field of police and amenity authorities of the Russian Empire and Ukraine within the medical and social service in the 18th-19th centuries. Materials and methods: The structure of the article corresponds to the problem city and chronology principles, using the following methods and techniques of scientific learning: the systemic, historic, regulatory comparative, logical and structural-functional analysis of the studied medical-legal phenomena. The study sources are the scientific publications, collections of laws and executive orders of the Russian Empire and Ukraine in the 18th-19th centuries. Review: As a result of the performed work it can be determined were the main directions of the police competence in late 18th- early 19th centuries. Conclusion: Preserving health, treatment of the ill and injured, management of medical and social service of those in need, holding various preventive activities and supporting safe environment and regulating the safety of food were the main directions of the police competence in late 18th- early 19th centuries.

  14. 76 FR 57767 - Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... NUCLEAR REGULATORY COMMISSION [NRC-2011-0204] Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations for Operating Reactors AGENCY: Nuclear Regulatory Commission... FR 54507), that requested public comment on Draft NRC Generic Letter 2011- XX: Seismic Risk...

  15. Clinical review of 95 patients with 46,XX disorders of sex development based on the new Chicago classification.

    PubMed

    Öcal, Gönül; Berberoğlu, Merih; Sıklar, Zeynep; Aycan, Zehra; Hacıhamdioglu, Bülent; Savas Erdeve, Şenay; Çamtosun, Emine; Kocaay, Pınar; Ruhi, Hatice I; Kılıç, Birim G; Tukun, Ajlan

    2015-02-01

    The aim of our study was to determine the etiologic distribution of 46,XX disorder of sexual development (DSD) according to the new DSD classification system and to evaluate the clinical features of this DSD subgroup in our patient cohort. The evaluation criteria and clinical findings of 95 46,XX patients were described by clinical presentation, gonadal morphology, genital anatomy, associated dysmorphic features, presence during prenatal period with/without postnatal virilization, hormonal characteristics, and presence or absence of steroidogenic defects among 319 patients with DSD. Types and ratios of each presentation of our 95 patients with 46,XX DSD were as follows: 82 had androgen excess (86.3%): (74 had classical congenital adrenal hyperplasia, 2 had CAH variant possibility of P450-oxidoreductase gene defect), 6 had disorders of ovarian development (6.3%): (1 patient had gonadal dysgenesis with virilization at birth with bilateral streak gonad, 4 patients had complete gonadal dysgenesis, and 1 patient had ovotesticular DSD) and 7 had other 46,XX DSD. Two sisters, who had 46,XX complete gonadal dysgenesis,were diagnosed with Perrault Syndrome with ovarian failure due to streak gonads and associated with sensorineural deafness. 46,XX DSD are usually derived from intrauterine virilization and CAH is the most common cause of 46,XX DSD due to fetal androgen exposure. Copyright © 2015 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  16. Records of auroral candidates and sunspots in Rikkokushi, chronicles of ancient Japan from early 7th century to 887

    NASA Astrophysics Data System (ADS)

    Hayakawa, Hisashi; Iwahashi, Kiyomi; Tamazawa, Harufumi; Ebihara, Yusuke; Kawamura, Akito Davis; Isobe, Hiroaki; Namiki, Katsuko; Shibata, Kazunari

    2017-12-01

    We present the results of the surveys on sunspots and auroral candidates in Rikkokushi, Japanese official histories from the early 7th century to 887, to review the solar and auroral activities. In total, we found one sunspot record and 13 auroral candidates in Rikkokushi. We then examine the records of the sunspots and auroral candidates, compare the auroral candidates with the lunar phase to estimate their reliability, and compare the records of the sunspots and auroral candidates with the contemporary total solar irradiance reconstructed from radioisotope data. We also identify the locations of the observational sites to review possible equatorward expansion of the auroral oval. These discussions suggest a major gap in auroral candidates from the late 7th to early 9th centuries, which includes the candidate of the grand minimum reconstructed from the radioisotope data, a similar tendency as the distributions of sunspot records in contemporary China, and a relatively high magnetic latitude of observational sites with a higher potential for observing aurorae more frequently than at present.

  17. Long term outcomes in 46, XX adult patients with congenital adrenal hyperplasia reared as males.

    PubMed

    Khattab, A; Yau, M; Qamar, A; Gangishetti, P; Barhen, A; Al-Malki, S; Mistry, H; Anthony, W; Toralles, M B; New, Maria I

    2017-01-01

    Patients with Congenital Adrenal Hyperplasia (CAH) owing to 21-hydroxylase deficiency and whose karyotype is 46, XX are usually assigned to the female gender. Reported herein are the long term outcomes in three patients with CAH whose karyotype is 46, XX and who were reared as males. A retrospective review of three CAH patients with a 46, XX karyotype who were reared as males was conducted. Gender assignment, clinical and biochemical data, pre and post-genitoplasty genital examinations were reviewed. Gender identity was tested by an extensive questionnaire. Gender role, sexual preference, marital status and sexual satisfaction were evaluated by interview. The three patients were genotyped for the CYP21A2 gene confirming the diagnosis of CAH. Owing to genital virilization, cultural preferences for male gender and the lack of newborn screening programs the three patients reported herein were assigned to the male gender at birth before the diagnosis of CAH was established. In adulthood the patients remained significantly virilized. Thorough psychosexual assessments in adulthood revealed well established male gender identities compatible with their male gender assignments at birth. In all three patients, gender role and behavior were consistent with male gender identity including sexual intercourse with female partners. The three patients reported herein revealed that male gender assignment to CAH patients with a 46, XX karyotype may have a successful outcome providing there is strong parental support and expert endocrine care. No standard guidelines have been published for the gender assignment of CAH patients with a 46, XX karyotype and genital ambiguity. More studies concerning gender assignment in CAH patients with a 46, XX karyotype reared as males are needed. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. XX male sex reversal with genital abnormalities associated with a de novo SOX3 gene duplication.

    PubMed

    Moalem, Sharon; Babul-Hirji, Riyana; Stavropolous, Dmitri J; Wherrett, Diane; Bägli, Darius J; Thomas, Paul; Chitayat, David

    2012-07-01

    Differentiation of the bipotential gonad into testis is initiated by the Y chromosome-linked gene SRY (Sex-determining Region Y) through upregulation of its autosomal direct target gene SOX9 (Sry-related HMG box-containing gene 9). Sequence and chromosome homology studies have shown that SRY most probably evolved from SOX3, which in humans is located at Xq27.1. Mutations causing SOX3 loss-of-function do not affect the sex determination in mice or humans. However, transgenic mouse studies have shown that ectopic expression of Sox3 in the bipotential gonad results in upregulation of Sox9, resulting in testicular induction and XX male sex reversal. However, the mechanism by which these rearrangements cause sex reversal and the frequency with which they are associated with disorders of sex development remains unclear. Rearrangements of the SOX3 locus were identified recently in three cases of human XX male sex reversal. We report on a case of XX male sex reversal associated with a novel de novo duplication of the SOX3 gene. These data provide additional evidence that SOX3 gain-of-function in the XX bipotential gonad causes XX male sex reversal and further support the hypothesis that SOX3 is the evolutionary antecedent of SRY. Copyright © 2012 Wiley Periodicals, Inc.

  19. 8- to 13-micron spectroscopy of Comet Levy 1990 XX

    NASA Technical Reports Server (NTRS)

    Lynch, David K.; Russell, Ray W.; Hackwell, John A.; Hanner, Martha S.; Hammel, Heidi B.

    1992-01-01

    The results are reported of IR spectroscopy of Comet Levy 1990 XX over a three-day period when the comet was about 1.54 AU from the sun roughly 70 days before perihelion. Comet Levy 1990 XX was bright, and for at least part of its inbound journey toward perihelion, active. At a distance of 1.54 AU from the sun it showed strong structured silicate emission with peaks or shoulders at 9.8 and 11.2 microns. These features resemble those of Comets P/Halley and Bradfield 1987 XXIX. The comet was variable in brightness. Specifically, the contrast of the silicate features changed by a factor of two relative to the continuum level and showed some evidence for a shape change as well.

  20. Preserving Sydney's built heritage in the early twentieth century.

    PubMed

    Freestone, R

    1999-01-01

    Modernity has been antithetical to heritage conservation in the twentieth century. The value of inherited buildings was not widely acknowledged by government officials, politicians, architects, planners and the broader community until the' 1970s. From the turn of the century, a coalition of pioneering preservationists in Sydney confronted a formidable growth mentality, which linked preservation with economic and cultural stasis. This article explores the objectives, composition, ideology, modus operandi and record of the fledgeling preservation movement against the backdrop of modernisation.

  1. Teachers' Lyceums in Early Nineteenth-Century America

    ERIC Educational Resources Information Center

    Spearman, Mindy

    2009-01-01

    Most historians interested in the cultural history of nineteenth-century America are familiar with the lyceum movement, first popularized by Massachusetts' Josiah Holbrook. While lyceums were extremely popular during the 1820s and 1830s, they disappeared with the advent of the Civil War--though later providing inspiration for Chautauquan lectures…

  2. Botany on a plate. Pleasure and the power of pictures in promoting early nineteenth-century scientific knowledge.

    PubMed

    Secord, Anne

    2002-03-01

    In early nineteenth-century Britain the use of pictures in introducing novices to the study of science was contentious, leading to debates over the ways in which words and images constituted knowledge and over the role of pleasure in intellectual pursuits. While recent studies have stressed visual representation as a critical element of science and considered its relation to the written word in conveying information, this essay explores the nineteenth-century preoccupation with the mind and mental faculties in relation to corporeal responses to explain concerns over the role of images and the process of recognition. By considering illustration in this way, it argues that popular botany was defined by many expert naturalists as the means by which private individuals could best be encouraged to extend their aesthetic appreciation and love of plants to an active and participatory pursuit of science.

  3. Evidence of active dune sand on the Great Plains in the 19th century from accounts of early explorers

    USGS Publications Warehouse

    Muhs, D.R.; Holliday, V.T.

    1995-01-01

    Dune fields are found in several areas of the Great Plains, and though mostly stabilised today, the accounts of early explorers show that they were more mobile in the last century. Using an index of dune mobility and tree ring data, it is found that these periods of mobility were related to temperature-induced drought, the high temperatures increasing evapotranspiration. Explorers also record that rivers upwind of these dune fields had shallow braided channels in the 19th century, and these would have supplied further aeolian sand. It is concluded that these dunes are extremely susceptible to climate change and that it may not need global warming to increase their mobility again. -K.Clayton

  4. Some doctors of medicine who published optometry books and played significant roles in early twentieth century optometric education.

    PubMed

    Goss, David A

    2011-01-01

    This paper provides brief profiles of four doctors of medicine who wrote books for optometrists and who were faculty members in, and/or directors of, optometry schools in the early twentieth century. Those studied were Thomas G. Atkinson (1870-1946), Marshall B. Ketchum (1856-1937), Joseph I. Pascal (1890-1955), and Clarence W. Talbot (1883-1958). The content of the books they wrote is also discussed.

  5. "A Pleasant Way of Teaching the Little Ones to Recognise Flowers": Instructional Nature Plays in Early 20th Century Britain

    ERIC Educational Resources Information Center

    Palmer, Amy

    2017-01-01

    This article analyses plays written for child performers in the early twentieth century. The plays chosen are classified as "instructional" and aimed at developing pupils' knowledge of the curriculum. The focus is on understanding why these plays were useful for Froebelian educators in the period. Friedrich Froebel (1782-1852) was a…

  6. Annual minimum temperature variations in early 21st century in Punjab, Pakistan

    NASA Astrophysics Data System (ADS)

    Jahangir, Misbah; Maria Ali, Syeda; Khalid, Bushra

    2016-01-01

    Climate change is a key emerging threat to the global environment. It imposes long lasting impacts both at regional and national level. In the recent era, global warming and extreme temperatures have drawn great interest to the scientific community. As in a past century considerable increase in global surface temperatures have been observed and predictions revealed that it will continue in the future. In this regard, current study mainly focused on analysis of regional climatic change (annual minimum temperature trends and its correlation with land surface temperatures in the early 21st century in Punjab) for a period of 1979-2013. The projected model data European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-Interim) has been used for eight Tehsils of Punjab i.e., annual minimum temperatures and annual seasonal temperatures. Trend analysis of annual minimum and annual seasonal temperature in (Khushab, Noorpur, Sargodha, Bhalwal, Sahiwal, Shahpur, Sillanwali and Chinoit) tehsils of Punjab was carried out by Regression analysis and Mann-Kendall test. Landsat 5 Thematic Mapper (TM) data was used in comparison with Model data for the month of May from the years 2000, 2009 and 2010. Results showed that no significant trends were observed in annual minimum temperature. A significant change was observed in Noorpur, Bhalwal, Shahpur, Sillanwali, Sahiwal, Chinoit and Sargodha tehsils during spring season, which indicated that this particular season was a transient period of time.

  7. 46,XX T testicular disorder of sex development. Case report.

    PubMed

    Pastor Guzmán, José María; Pastor Navarro, Hector; Quintanilla Mata, María Luisa; Carrión López, Pedro; Martínez Ruíz, Jesús; Martínez Sanchiz, Carlos; Perán Teruel, Miguel; Virseda Rodríguez, Julio Antonio

    2011-06-01

    We present a case of X-Y translocation with male phenotype (46,XX testicular disorder of sex development) and review the literature. Disorders of sex development with mismatch of genetic, gonadal and phenotypic sex are quite rare, and some are due to genetic or chromosomal abnormalities. The karyotype was investigated by a cytogenetic study of peripheral blood (phytohemagglutinin-timulated lymphocyte culture over 72 hours). G-banding analysis of 25 metaphases showed a 46,XX chromosome constitution (46 chromosomes with XX sexual composition). Fluorescence in situ hybridization (FISH) analysis with probes for X centromeres and the sex-determining region of the Y chromosome (SRY) (testis-determining factor gene) showed two X chromosomes. The analysis also showed the SRY signal in the telomeric region of the short arm of one of the chromosomes. In recent years, a number of other genes involved in disorders of sex development in animals and humans have also been identified. Genetic defects in the peptide hormone receptors, members of the steroid receptor superfamily, and other transcription factors, as well as any of a series of enzymes and cofactors involved in steroid biosynthesis can cause abnormal determination and differentiation. Although chromosomal abnormalities are rarely present in patients with apparently normal external genitalia, they should be considered in urology consultations by adolescents and adults, particularly in the investigation of gynecomastia or infertility.

  8. High Temperature Increases the Masculinization Rate of the All-Female (XX) Rainbow Trout “Mal” Population

    PubMed Central

    Valdivia, Karina; Jouanno, Elodie; Volff, Jean-Nicolas; Galiana-Arnoux, Delphine; Guyomard, René; Helary, Louise; Mourot, Brigitte; Fostier, Alexis; Quillet, Edwige; Guiguen, Yann

    2014-01-01

    Salmonids are generally considered to have a robust genetic sex determination system with a simple male heterogamety (XX/XY). However, spontaneous masculinization of XX females has been found in a rainbow trout population of gynogenetic doubled haploid individuals. The analysis of this masculinization phenotype transmission supported the hypothesis of the involvement of a recessive mutation (termed mal). As temperature effect on sex differentiation has been reported in some salmonid species, in this study we investigated in detail the potential implication of temperature on masculinization in this XX mal-carrying population. Seven families issued from XX mal-carrying parents were exposed from the time of hatching to different rearing water temperatures ((8, 12 and 18°C), and the resulting sex-ratios were confirmed by histological analysis of both gonads. Our results demonstrate that masculinization rates are strongly increased (up to nearly two fold) at the highest temperature treatment (18°C). Interestingly, we also found clear differences between temperatures on the masculinization of the left versus the right gonads with the right gonad consistently more often masculinized than the left one at lower temperatures (8 and 12°C). However, the masculinization rate is also strongly dependent on the genetic background of the XX mal-carrying families. Thus, masculinization in XX mal-carrying rainbow trout is potentially triggered by an interaction between the temperature treatment and a complex genetic background potentially involving some part of the genetic sex differentiation regulatory cascade along with some minor sex-influencing loci. These results indicate that despite its rather strict genetic sex determinism system, rainbow trout sex differentiation can be modulated by temperature, as described in many other fish species. PMID:25501353

  9. Ovotesticular disorder of sexual development and a rare 46,XX/47,XXY karyotype.

    PubMed

    Ozsu, Elif; Mutlu, Gul Yesiltepe; Cizmecioglu, Filiz M; Ekingen, Gülsen; Muezzinoglu, Bahar; Hatun, Sukru

    2013-01-01

    Ovotesticular disorder of sexual development (DSD) is characterized by the presence of both ovarian and testicular tissues in the same individual. The most common karyotype is 46,XX. Here, we report the case of a boy with a 46,XX/47,XXY karyotype diagnosed as ovotesticular DSD by gonadal biopsy. A 5-month-old boy presented with hypospadias, unilateral cryptorchidism, and a micropenis. Pelvic magnetic resonance imaging revealed a suspicious gonad tissue that is solid in structure in the right scrotum and a suspicious gonad that is cystic in structure in the left inguinal canal. He underwent a diagnostic laparoscopy. Cytogenetic analysis of peripheral blood revealed a 46,XX/47,XXY karyotype. Histopathologic examination of the left gonad showed ovarian tissue containing primordial follicles with ipsilateral undifferentiated tuba uterina. The right gonad showed immature testis tissue. He underwent left gonadectomy and hypospadias repair, and was raised as a male. Through this rare case, we highlight the importance of histological and cytogenetic investigation in DSD.

  10. Discordant sex in monozygotic XXY/XX twins: a case report.

    PubMed

    Tachon, G; Lefort, G; Puechberty, J; Schneider, A; Jeandel, C; Boulot, P; Prodhomme, O; Meyer, P; Taviaux, S; Touitou, I; Pellestor, F; Geneviève, D; Gatinois, V

    2014-12-01

    We report a case of discordant phenotypic sex in monozygotic twins mosaic 47,XXY/46,XX: monozygotic heterokaryotypic twins. The twins presented with cognitive and comprehension delay, behavioural and language disorders, all symptoms frequently reported in Klinefelter syndrome. Molecular zygosity analysis with several markers confirmed that the twins are in effect monozygotic (MZ). Array comparative genomic hybridization found no evidence for the implication of copy number variation in the phenotypes. Ultrasound scans of the reproductive organs revealed no abnormalities. Endocrine tests showed a low testosterone level in Twin 1 (male phenotype) and a low gonadotrophin level in Twin 2 (female phenotype) which, combined with the results from ultrasound examination, provided useful information for potentially predicting the future fertility potential of the twins. Blood karyotypes revealed the presence of a normal 46,XX cell line and an aneuploïd 47,XXY cell line in both patients. Examination of the chromosome constitutions of various tissues such as blood, buccal smear and urinary sediment not surprisingly showed different proportions for the 46,XX and 47,XXY cell lines, which most likely explains the discordant phenotypic sex and mild Klinefelter features. The most plausible underlying biological mechanism is a post-zygotic loss of the Y chromosome in an initially 47,XXY zygote. This would result in an embryo with both 46,XX and 47,XXY cells lines which could subsequently divide into two monozygotic embryos through a twinning process. The two cell lines would then be distributed differently between tissues which could result in phenotypic discordances in the twins. These observations emphasize the importance of regular paediatric evaluations to determine the optimal timing for fertility preservation measures and to detect new Klinefelter features which could appear throughout childhood in the two subjects. © The Author 2014. Published by Oxford University Press on

  11. Freedom of Speech as Protected by the States: A Review of Late Nineteenth and Early Twentieth Century State Court Decisions.

    ERIC Educational Resources Information Center

    Herbeck, Dale A.

    While some analysts have asserted that the First Amendment was intended to prohibit laws against seditious libel (speech overtly critical of the government), the judicial record reveals a willingness to tolerate some onerous infringements on free expression. In the late 19th and early 20th centuries, 25 states passed "sedition" or…

  12. Educational Ideas in Geography Education in Sweden during the Nineteenth and Early Twentieth Centuries: The Relationship between Maps and Texts

    ERIC Educational Resources Information Center

    Hennerdal, Pontus

    2015-01-01

    Descriptions of the geography education of the nineteenth and early twentieth centuries in Sweden are typically offered to contrast with current ideas in geography education, and the content of geography textbooks is the focus of this comparison. The role of maps and visual pedagogy are ignored, and the educational ideas developed from regional…

  13. An Unfashionable Rhetoric in the Fifteenth Century.

    ERIC Educational Resources Information Center

    Woods, Marjorie Curry

    1989-01-01

    Reveals the continued importance of medieval rhetorical pedagogy throughout the high Middle Ages and early Renaissance by exploring the fifteenth-century popularity, uses of, and references to Geoffrey of Vinsauf's "Poetria nova" (a thirteenth-century verse treatise on the composition of poetry according to rhetorical principles). (SR)

  14. Crop changes from the XVI century to the present in a hill/mountain area of eastern Liguria (Italy)

    PubMed Central

    Gentili, Rodolfo; Gentili, Elio; Sgorbati, Sergio

    2009-01-01

    Background Chronological information on the composition and structure of agrocenoses and detailed features of land cover referring to specific areas are uncommon in ethnobotanical studies, especially for periods before the XIX century. The aim of this study was to analyse the type of crop or the characteristics of soil cover from the XVI century to the present. Methods This diachronic analysis was accomplished through archival research on the inventories of the Parish of St. Mary and those of the Municipality of Pignone and from recent surveys conducted in an area of eastern Liguria (Italy). Results Archival data revealed that in study area the primary means of subsistence during the last five centuries, until the first half of the XX century, was chestnuts. In the XVIII and XIX centuries, crop diversification strongly increased in comparison with previous and subsequent periods. In more recent times, the abandonment of agricultural practices has favoured the re-colonisation of mixed woodland or cluster-pine woodland. Conclusion Ancient documents in the ecclesiastic or municipal inventories can be a very useful tool for enhancing the knowledge of agricultural practice, as well as of subsistence methods favoured by local populations during a particular time and for reconstructing land use change over time. PMID:19361339

  15. J. E. W. Wallin's Diagnostic Theory for Classifying the Feeble-Minded and Backward in Early Twentieth-Century Public Schools in America

    ERIC Educational Resources Information Center

    Yoshii, Ryo

    2016-01-01

    In the late nineteenth and early twentieth centuries, American psychologists began addressing problems related to the intellectual capacity of students enrolled in public schools. This paper focuses on the role and influence of psychologists in addressing these problems, specifically the difficulty of classifying students deemed feeble-minded and…

  16. Identical NR5A1 Missense Mutations in Two Unrelated 46,XX Individuals with Testicular Tissues.

    PubMed

    Igarashi, Maki; Takasawa, Kei; Hakoda, Akiko; Kanno, Junko; Takada, Shuji; Miyado, Mami; Baba, Takashi; Morohashi, Ken-Ichirou; Tajima, Toshihiro; Hata, Kenichiro; Nakabayashi, Kazuhiko; Matsubara, Yoichi; Sekido, Ryohei; Ogata, Tsutomu; Kashimada, Kenichi; Fukami, Maki

    2017-01-01

    The role of monogenic mutations in the development of 46,XX testicular/ovotesticular disorders of sex development (DSD) remains speculative. Although mutations in NR5A1 are known to cause 46,XY gonadal dysgenesis and 46,XX ovarian insufficiency, such mutations have not been implicated in testicular development of 46,XX gonads. Here, we identified identical NR5A1 mutations in two unrelated Japanese patients with 46,XX testicular/ovotesticular DSD. The p.Arg92Trp mutation was absent from the clinically normal mothers and from 200 unaffected Japanese individuals. In silico analyses scored p.Arg92Trp as probably pathogenic. In vitro assays demonstrated that compared with wild-type NR5A1, the mutant protein was less sensitive to NR0B1-induced suppression on the SOX9 enhancer element. Other sequence variants found in the patients were unlikely to be associated with the phenotype. The results raise the possibility that specific mutations in NR5A1 underlie testicular development in genetic females. © 2016 WILEY PERIODICALS, INC.

  17. Expression of selected genes escaping from X inactivation in the 41, XX(Y)* mouse model for Klinefelter's syndrome.

    PubMed

    Werler, Steffi; Poplinski, Andreas; Gromoll, Jörg; Wistuba, Joachim

    2011-06-01

    We hypothesized that patients with Klinefelter's syndrome (KS) not only undergo X inactivation, but also that genes escape from inactivation. Their transcripts would constitute a significant difference, as male metabolism is not adapted to a 'female-like' gene dosage. We evaluated the expression of selected X-linked genes in our 41, XX(Y)* male mice to determine whether these genes escape inactivation and whether tissue-specific differences occur. Correct X inactivation was identified by Xist expression. Relative expression of X-linked genes was examined in liver, kidney and brain tissue by real-time PCR in adult XX(Y)* and XY* males and XX females. Expression of genes known to escape X inactivation was analysed. Relative mRNA levels of Pgk1 (control, X inactivated), and the genes Eif2s3x, Kdm5c, Ddx3x and Kdm6a escaping from X inactivation were quantified from liver, kidney and brain. Pgk1 mRNA expression showed no difference, confirming correct X inactivation. In kidney and liver, XX(Y)* males resembled the female expression pattern in all four candidate genes and were distinguishable from XY* males. Contrastingly, in brain tissue XX(Y)* males expressed all four genes higher than male and female controls. Altered expression of genes escaping X inactivation probably contributes directly to the XX(Y)* phenotype. © 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.

  18. SU-E-T-472: Improvement of IMRT QA Passing Rate by Correcting Angular Dependence of MatriXX

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chen, Q; Watkins, W; Kim, T

    2015-06-15

    Purpose: Multi-channel planar detector arrays utilized for IMRT-QA, such as the MatriXX, exhibit an incident-beam angular dependent response which can Result in false-positive gamma-based QA results, especially for helical tomotherapy plans which encompass the full range of beam angles. Although MatriXX can use with gantry angle sensor to provide automatically angular correction, this sensor does not work with tomotherapy. The purpose of the study is to reduce IMRT-QA false-positives by correcting for the MatriXX angular dependence. Methods: MatriXX angular dependence was characterized by comparing multiple fixed-angle irradiation measurements with corresponding TPS computed doses. For 81 Tomo-helical IMRT-QA measurements, two differentmore » correction schemes were tested: (1) A Monte-Carlo dose engine was used to compute MatriXX signal based on the angular-response curve. The computed signal was then compared with measurement. (2) Uncorrected computed signal was compared with measurements uniformly scaled to account for the average angular dependence. Three scaling factor (+2%, +2.5%, +3%) were tested. Results: The MatriXX response is 8% less than predicted for a PA beam even when the couch is fully accounted for. Without angular correction, only 67% of the cases pass the >90% points γ<1 (3%, 3mm). After full angular correction, 96% of the cases pass the criteria. Of three scaling factors, +2% gave the highest passing rate (89%), which is still less than the full angular correction method. With a stricter γ(2%,3mm) criteria, the full angular correction method was still able to achieve the 90% passing rate while the scaling method only gives 53% passing rate. Conclusion: Correction for the MatriXX angular dependence reduced the false-positives rate of our IMRT-QA process. It is necessary to correct for the angular dependence to achieve the IMRT passing criteria specified in TG129.« less

  19. Rapid changes in the seasonal sea level cycle along the US Gulf coast in the early 21st century

    NASA Astrophysics Data System (ADS)

    Wahl, T.; Calafat, F. M.; Luther, M. E.

    2013-12-01

    The seasonal cycle is an energetic component in the sea level spectrum and dominates the intra-annual sea level variability outside the semidiurnal and diurnal tidal bands in most regions. Changes in the annual or semi-annual amplitudes or phase lags have an immediate impact on marine coastal systems. Increases in the amplitudes or phase shifts towards the storm surge season may for instance exacerbate the risk of coastal flooding and/or beach erosion, and the ecological health of estuarine systems is also coupled to the seasonal sea level cycle. Here, we investigate the temporal variability of the seasonal harmonics along the US Gulf of Mexico (GOM) coastline using records from 13 tide gauges providing at least 30 years of data in total and at least 15 years for the period after 1990. The longest records go back to the early 20th century. Running Fourier analysis (with a window length of 5-years) is used to extract the seasonal harmonics from the observations. The resulting time series show a considerable decadal variability and no longer-term changes are found in the phase lags and the semi-annual amplitude. The amplitude of the dominating annual cycle in contrast shows a tendency towards higher values since the turn of the century at tide gauges in the eastern part of the GOM. This increase of up to more than 25% is found to be significant at the 90% confidence level for most tide gauges along the coastline of West Florida and at the 75% confidence level for virtually all stations in the eastern GOM (from Key West to Dauphin Island). Monthly mean sea level sub-series show that the changes are partly due to smaller values in the cold season but mostly a result of higher values in the warm season, i.e. sea levels tend to be higher during the hurricane season. We use information on the steric sea level component, sea surface and air temperature, wind forcing, precipitation, and sea level pressure to explain the mechanisms driving the decadal variability in the

  20. Metal Construction Toys of the Early Twentieth Century: Their Astronomical Applications

    NASA Astrophysics Data System (ADS)

    Rumstay, K. S.

    2004-12-01

    During the early twentieth century several toy manufacturers around the globe introduced construction toys in the form of sets of metal parts which could be assembled into a variety of models. The two most successful were the Erector Set, introduced in the United States by A.C. Gilbert in 1913, and the Meccano Set, patented in 1901 in England by Frank Hornby. Whereas the Erector Set never developed beyond being a child's toy, Hornby envisioned his Meccano system as providing a way to teach principles of mechanical engineering to young schoolboys. Indeed, his sets were first marketed under the name "Mechanics Made Easy", and were endorsed by Dr. H.S. Hele-Shaw, Head of the Engineering Department at Liverpool University. Popularity of the new Meccano sets spread throughout the world, spawning the formation of numerous amateur societies composed of adolescent boys and an increasing number of adult hobbyists. The variety of parts increased during the first third of the century, and increasingly sophisticated models were constructed and exhibited in competitive events. Among these were several clocks of remarkable accuracy, and at least one equatorial mounting for a small astronomical telescope. At the same time, many university science and engineering departments found these interchangeable metal parts invaluable in the construction of experimental apparatus. In 1934 a small-scale replica of Vannevar Bush's Differential Analyzer was constructed at the University of Manchester, and used for many years to perform mathematical computations. The introduction in 1928 of a flanged ring with 73 (a sub-multiple of 365) teeth allowed for construction of accurate orreries and astronomical clocks. The most remarkable of these was the Astronomical Clock constructed in the period 1924-1932 by M. Alexandre Rahm of Paris.

  1. A major locus on mouse chromosome 18 controls XX sex reversal in Odd Sex (Ods) mice.

    PubMed

    Qin, Yangjun; Poirier, Christophe; Truong, Cavatina; Schumacher, Armin; Agoulnik, Alexander I; Bishop, Colin E

    2003-03-01

    We have previously reported a dominant mouse mutant, Odd sex (Ods), in which XX Ods/+ mice on the FVB/N background show complete sex reversal, associated with expression of Sox9 in the fetal gonads. Remarkably, when crossed to the A/J strain approximately 95% of the (AXFVB) F(1) XX Ods/+ mice developed as fully fertile, phenotypic females, the remainder developing as males or hermaphrodites. Using a (AXFVB) F(2) population, we conducted a genome-wide linkage scan to identify the number and chromosomal location of potential Ods modifier genes. A single major locus termed Odsm1 was mapped to chromosome 18, tightly linked to D18Mit189 and D18Mit210. Segregation at this locus could account for the presence of sex reversal in 100% of XX Ods/+ mice which develop as males, for the absence of sex reversal in approximately 92% of XX Ods/+ mice which develop as females, and for the mixed sexual phenotype in approximately 72% of XX Ods/+ mice that develop with ambiguous genitalia. We propose that homozygosity for the FVB-derived allele strongly favors Ods sex reversal, whereas homozygosity for the A/J-derived allele inhibits it. In mice heterozygous at Odsm1, the phenotypic outcome, male, female or hermaphrodite, is determined by a complex interaction of several minor modifying loci. The close proximity of Smad2, Smad7 and Smad4 to D18Mit189/210 provides a potential mechanism through which Odsm1 might act.

  2. Sex steroid levels in XY males and sex-reversed XX males, of rainbow trout (Oncorhynchus mykiss), during the reproductive cycle.

    PubMed

    Espinosa, E; Josa, A; Gil, L; González, N

    2011-02-01

    In this study, the annual cycle of the gonadal steroids testosterone (T), 11-ketotestosterone (11-KT), 17β-oestradiol (E2) and 17α, 20β-dihydroxy-4-pregnen-3-one (DHP) was determined using radioimmunoassay and then compared, for XY males (n=35) and sex-reversed XX males (n=27) rainbow trout, to establish possible endocrinology differences. Both in XY males and sex-reversed XX males, significant correlation was shown between body weight and T (r=0.5046 and 0.34078, respectively; p<0.0001) or KT (r=0.52494 and 0.43545, respectively; p<0.0001) concentrations. Plasma androgen levels in XY and sex-reversed XX males were similar and showed an intense seasonal variation. The highest levels for T and 11-KT were detected from December to April with a peak in January (51.67 ± 5.11 and 61.95 ± 4.25 ng/ml, for XY males and 57.1 ± 5.82 and 59.27 ± 4.84 ng/ml, respectively, for XX males). In addition, there was a positive correlation (p<0.0001) between T and 11-KT levels for XY males (r=0.7533) and sex-reversed XX males (r=0.6019). Concentrations of DHP in XY males also showed seasonal variation with a peak in February (25.18 ± 12.99 ng/ml). However, DHP levels in sex-reversed XX males were undetectable (<0.1 ng/ml) over the year. Levels of E2 were undetectable through the year in both groups of trout. In conclusion, the androgenic and oestrogenic profiles of sex-reversed XX males were similar to those observed in XY males. The only difference in the annual gonadal steroid cycle between XY and sex-reversed XX males was in the DHP profile. © 2009 Blackwell Verlag GmbH.

  3. 29. Coke oven byproduct building "XX" with ammonia stills; powerhouse ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. Coke oven by-product building "XX" with ammonia stills; powerhouse with 8 sisters (stacks) in background; conveyor #20 (with break) on right, pulevrized coal storage bunker on left. Looking north/northwest - Rouge Steel Company, 3001 Miller Road, Dearborn, MI

  4. Painful ovulation in a 46,XX SRY -ve adult male with SOX9 duplication.

    PubMed

    Shankara Narayana, Nandini; Kean, Anne-Maree; Ewans, Lisa; Ohnesorg, Thomas; Ayers, Katie L; Watson, Geoff; Vasilaras, Arthur; Sinclair, Andrew H; Twigg, Stephen M; Handelsman, David J

    2017-01-01

    46,XX disorders of sexual development (DSDs) occur rarely and result from disruptions of the genetic pathways underlying gonadal development and differentiation. We present a case of a young phenotypic male with 46,XX SRY-negative ovotesticular DSD resulting from a duplication upstream of SOX9 presenting with a painful testicular mass resulting from ovulation into an ovotestis. We present a literature review of ovulation in phenotypic men and discuss the role of SRY and SOX9 in testicular development, including the role of SOX9 upstream enhancer region duplication in female-to-male sex reversal. In mammals, the early gonad is bipotent and can differentiate into either a testis or an ovary. SRY is the master switch in testis determination, responsible for differentiation of the bipotent gonad into testis.SRY activates SOX9 gene, SOX9 as a transcription factor is the second major gene involved in male sex determination. SOX9 drives the proliferation of Sertoli cells and activates AMH/MIS repressing the ovary. SOX9 is sufficient to induce testis formation and can substitute for SRY function.Assessing karyotype and then determination of the presence or absence of Mullerian structures are necessary serial investigations in any case of DSD, except for mixed gonadal dysgenesis identified by karyotype alone.Treatment is ideal in a multidisciplinary setting with considerations to genetic (implications to family and reproductive recurrence risk), psychological aspects (sensitive individualized counseling including patient gender identity and preference), endocrinological (hormone replacement), surgical (cosmetic, prophylactic gonadectomy) fertility preservation and reproductive opportunities and metabolic health (cardiovascular and bones).

  5. Does 45,X/46,XX mosaicism with 6-28% of aneuploidy affect the outcomes of IVF or ICSI?

    PubMed

    Homer, L; Morel, F; Gallon, F; Le Martelot, M-T; Amice, V; Kerlan, V; De Braekeleer, M

    2012-07-01

    Several studies have shown an increased frequency of chromosomal aberrations in female partners of couples examined prior to intracytoplasmic sperm injection (ICSI). A retrospective cohort study was performed to determine whether 45,X/46,XX mosaicism affects the outcomes of in vitro fertilization (IVF) or ICSI. Forty-six women with a 45,X/46,XX karyotype with 6-28% of aneuploidy were compared with 59 control women (46,XX), matched for age, from the female population who underwent IVF or ICSI between 1 January 1996 and 31 December 2006 at the Reproductive Medicine Unit at Brest University Hospital. The outcomes of 254 treatment cycles were compared according to patient karyotype. No difference was found in the number of retrieved oocytes (8.9 ± 5.5 vs 8.5 ± 4.7; p=0.56) or the number of mature oocytes (7.4 ± 4.7 vs 6.9 ± 4.2; p=0.49) between the 45,X/46,XX group and the 46,XX group, respectively. Fertilization rates did not differ between the groups for either IVF or ICSI. In addition, no difference was found in the pregnancy rate by cycle (17.4% vs 18.7%, respectively; p=0.87). The percentage of first-trimester miscarriages was similar in both groups (13.6% vs 12.5%, respectively; p=0.51). 45,X/46,XX mosaicism with 6-28% of aneuploidy has no adverse effect on the outcomes of IVF or ICSI among women referred to assisted reproductive technologies. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  6. 49 CFR 1242.51 - Dismantling retired property and depreciation (accounts XX-27-39 and 62-27-00).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Dismantling retired property and depreciation (accounts XX-27-39 and 62-27-00). 1242.51 Section 1242.51 Transportation Other Regulations Relating to... (accounts XX-27-39 and 62-27-00). Separate common expenses in proportion to the separation of common repair...

  7. 49 CFR 1242.37 - Dismantling retired property and depreciation (accounts XX-26-39 and 62-26-00).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Dismantling retired property and depreciation (accounts XX-26-39 and 62-26-00). 1242.37 Section 1242.37 Transportation Other Regulations Relating to... (accounts XX-26-39 and 62-26-00). Separate common expenses in each account in proportion to the separation...

  8. Plastic body, permanent body: Czech representations of corporeality in the early twentieth century.

    PubMed

    Sleigh, Charlotte

    2009-12-01

    In the early twentieth century, the body was seen as both an ontogenetic and a phylogenetic entity. In the former case, its individual development, it was manifestly changeable, developing from embryo to maturity and thence to a state of decay. But in the latter case, concerning its development as a species, the question was an open one. Was its phylogenetic nature a stationary snapshot of the slow process of evolution, or was this too mutable? Historians have emphasised that the question of acquired inheritance remained open into the twentieth century; this paper explores how various constructions of the individual as a phylogenetic episode--a stage in the race's evolution--related to representations of the body in the same period. A discussion of the work of the brothers Josef and Karel Capek offers a contextualised answer to the question of bodily representation. Karel Capek (1890-1938) explored the nature of the 'average man' through two different organisms, the robot and the amphibian, epitomes respectively of corporeal permanence and plasticity. Josef Capek (1887-1945), along with other members of the Group of Plastic Artists, explored visual representations of the body that challenged cubist Bergsonian norms. In so doing, he affirmed what his brother also held: that despite the constrictions imposed by the oppressive political conditions in which the Czechs found themselves, the individual body was a fragile but fluid entity, capable of effecting change upon the future evolution of humankind.

  9. A Comprehensive Child Development Program; Title XX, Final Report.

    ERIC Educational Resources Information Center

    Whatley, Juanita T.

    This booklet describes the Comprehensive Child Day Care Program for the Atlanta Public School System, a Title XX Program. This program provided day care services for children of clients in various categories. The program goals for 1975-76 were geared toward providing comprehensive day care to encompass social services to the family and…

  10. Socialising Nurse Probationers in the Late 19th and Early 20th Centuries--Relevance of Historical Reflection for Modern Policy Makers.

    ERIC Educational Resources Information Center

    Lorentzon, Maria

    2003-01-01

    Historical records from London hospitals in the late 19th-early 20th centuries were analyzed for their depiction of nursing trainees. Analysis reveals a strong emphasis on character traits rather than intellectual ability. In contrast, the literature of the last 3 decades shows a contemporary concern for nurses as knowledgeable doers. (Contains 31…

  11. Refining the regulatory region upstream of SOX9 associated with 46,XX testicular disorders of Sex Development (DSD).

    PubMed

    Hyon, Capucine; Chantot-Bastaraud, Sandra; Harbuz, Radu; Bhouri, Rakia; Perrot, Nicolas; Peycelon, Matthieu; Sibony, Mathilde; Rojo, Sandra; Piguel, Xavier; Bilan, Frederic; Gilbert-Dussardier, Brigitte; Kitzis, Alain; McElreavey, Ken; Siffroi, Jean-Pierre; Bashamboo, Anu

    2015-08-01

    Disorders of Sex Development (DSD) are a heterogeneous group of disorders affecting gonad and/or genito-urinary tract development and usually the endocrine-reproductive system. A genetic diagnosis is made in only around 20% of these cases. The genetic causes of 46,XX-SRY negative testicular DSD as well as ovotesticular DSD are poorly defined. Duplications involving a region located ∼600 kb upstream of SOX9, a key gene in testis development, were reported in several cases of 46,XX DSD. Recent studies have narrowed this region down to a 78 kb interval that is duplicated or deleted respectively in 46,XX or 46,XY DSD. We identified three phenotypically normal patients presenting with azoospermia and 46,XX testicular DSD. Two brothers carried a 83.8 kb duplication located ∼600 kb upstream of SOX9 that overlapped with the previously reported rearrangements. This duplication refines the minimal region associated with 46,XX-SRY negative DSD to a 40.7-41.9 kb element located ∼600 kb upstream of SOX9. Predicted enhancer elements and evolutionary-conserved binding sites for proteins known to be involved in testis determination are located within this region. © 2015 Wiley Periodicals, Inc.

  12. XX/XY System of Sex Determination in the Geophilomorph Centipede Strigamia maritima

    PubMed Central

    Green, Jack E.; Dalíková, Martina; Sahara, Ken; Marec, František; Akam, Michael

    2016-01-01

    We show that the geophilomorph centipede Strigamia maritima possesses an XX/XY system of sex chromosomes, with males being the heterogametic sex. This is, to our knowledge, the first report of sex chromosomes in any geophilomorph centipede. Using the recently assembled Strigamia genome sequence, we identified a set of scaffolds differentially represented in male and female DNA sequence. Using quantitative real-time PCR, we confirmed that three candidate X chromosome-derived scaffolds are present at approximately twice the copy number in females as in males. Furthermore, we confirmed that six candidate Y chromosome-derived scaffolds contain male-specific sequences. Finally, using this molecular information, we designed an X chromosome-specific DNA probe and performed fluorescent in situ hybridization against mitotic and meiotic chromosome spreads to identify the Strigamia XY sex-chromosome pair cytologically. We found that the X and Y chromosomes are recognizably different in size during the early pachytene stage of meiosis, and exhibit incomplete and delayed pairing. PMID:26919730

  13. Dr. William Theodore Hodge: pioneer surgeon-apothecary in early-twentieth-century Western Australia.

    PubMed

    Kamien, Max

    2010-01-01

    In 2008 I chanced upon the lonely grave of Dr. William Theodore Hodge, buried in 1934, in the Derby Pioneer and Aboriginal Cemetery. He turned out to be the founding doctor of the practice in which I have worked for the past thirty years. Dr. Hodge migrated from England in 1896. He was the first western trained doctor to work in the Perth suburb of Claremont and in the wheat-belt town of Kellerberrin. He was an innovative and inventive modern doctor who became a legend in the Kimberley where he died tragically, on the day prior to his retirement, at the age of seventy-five. His story is illustrative of the life and medical practice of a pioneering doctor in metropolitan, rural, and remote practice in Western Australia at the end of the nineteenth and the early years of the twentieth centuries.

  14. Tropical mathematics and the financial catastrophe of the 17th century. Thermoeconomics of Russia in the early 20th century

    NASA Astrophysics Data System (ADS)

    Maslov, V. P.

    2010-03-01

    In the paper, an example is presented concerning relationships (which cannot be neglected) between mathematics and other sciences. In particular, the relationship between the tropical mathematics and the humanitarian-economic catastrophe of 17th century (related to slavery of Africans) is considered. The notion of critical state of economy of the 19th century is introduced by using the refined Fisher equation. A correspondence principle for thermodynamics of fluids and economics of the 19th century is presented.

  15. 30. XX byproducts building (containing coke gas compressors at north ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. XX by-products building (containing coke gas compressors at north end, ammonia stills in south end), #20 coal conveyor jutting out of top on east side, continuing out west side to bunker. Looking south/southeast - Rouge Steel Company, 3001 Miller Road, Dearborn, MI

  16. Coastal Fisheries in the Eastern Baltic Sea (Gulf of Finland) and Its Basin from the 15 to the Early 20th Centuries

    PubMed Central

    Lajus, Julia; Kraikovski, Alexei; Lajus, Dmitry

    2013-01-01

    The paper describes and analyzes original data, extracted from historical documents and scientific surveys, related to Russian fisheries in the southeastern part of the Gulf of Finland and its inflowing rivers during the 15- early 20th centuries. The data allow tracing key trends in fisheries development and in the abundance of major commercial species. In particular, results showed that, over time, the main fishing areas moved from the middle part of rivers downstream towards and onto the coastal sea. Changes in fishing patterns were closely interrelated with changes in the abundance of exploited fish. Anadromous species, such as Atlantic sturgeon, Atlantic salmon, brown trout, whitefish, vimba bream, smelt, lamprey, and catadromous eel were the most important commercial fish in the area because they were abundant, had high commercial value and were easily available for fishing in rivers. Due to intensive exploitation and other human-induced factors, populations of most of these species had declined notably by the early 20th century and have now lost commercial significance. The last sturgeon was caught in 1996, and today only smelt and lamprey support small commercial fisheries. According to historical sources, catches of freshwater species such as roach, ide, pike, perch, ruffe and burbot regularly occurred, in some areas exceeding half of the total catch, but they were not as important as migrating fish and no clear trends in abundance are apparent. Of documented marine catch, Baltic herring appeared in the 16th century, but did not become commercially significant until the 19th century. From then until now herring have been the dominant catch. PMID:24204735

  17. Cytogenic and molecular analyses of 46,XX male syndrome with clinical comparison to other groups with testicular azoospermia of genetic origin.

    PubMed

    Chiang, Han-Sun; Wu, Yi-No; Wu, Chien-Chih; Hwang, Jiann-Loung

    2013-02-01

    XX male is a rare sex chromosomal disorder in infertile men. The purpose of this study was to distinguish the clinical and genetic features of the 46,XX male syndrome from other more frequent, testicular-origin azoospermic causes of male infertility. To study 46,XX male syndrome, we compared clinical and endocrinological parameters to other groups with testicular-origin azoospermia, and to an age-matched group of healthy males and females as normal control. Fluorescent in situ hybridization for detection and localization of the sex-determining region of the Y gene (SRY), array-based comparative genomic hybridization screening, and real-time qualitative polymerase chain reaction of FGF9, WT1, NR5A1, and SPRY2 genes were performed in this genetic investigation. Our three patients with 46,XX male syndrome had a much higher follicular-stimulating hormone level, lower body height, lower testosterone level, and ambiguous external genitalia. One of the three patients with 46,XX male syndrome was SRY-negative. A further genetic study, including a comparative genomic hybridization array and real-time polymerase chain reaction, showed a gain of FGF9 copy numbers only in the SRY-negative 46,XX male. The genetic copy number of the FGF9 gene was duplicated in that case compared to the normal female control and was significantly lower than that of the normal male control. No such genomic gain was observed in the case of the two SRY-positive 46,XX males. Similar to clinical manifestations of 46,XX male syndrome, genetic evidence in this study suggests that FGF9 may contribute to sex reversal, but additional confirmation with more cases is still needed. Copyright © 2012. Published by Elsevier B.V.

  18. American Marriage in the Early Twenty-First Century

    ERIC Educational Resources Information Center

    Cherlin, Andrew J.

    2005-01-01

    During the past century the U.S. family system has seen vast changes--in marriage and divorce rates, cohabitation, childbearing, sexual behavior, and women's work outside the home. Andrew Cherlin reviews these historic changes, noting that marriage remains the most common living arrangement for raising children, but that children, especially poor…

  19. Gene expression profile during testicular development in patients with SRY-negative 46,XX testicular disorder of sex development.

    PubMed

    Mizuno, Kentaro; Kojima, Yoshiyuki; Kamisawa, Hideyuki; Moritoki, Yoshinobu; Nishio, Hidenori; Kohri, Kenjiro; Hayashi, Yutaro

    2013-12-01

    To elucidate alternative pathways in testicular development, we attempted to clarify the genetic characteristics of SRY-negative XX testes. We previously reported 5 cases of SRY-negative 46,XX testicular disorders of sex development and demonstrated that coordinated expression of genes such as SOX9, SOX3, and DAX1 was associated with testicular development. We performed a case-control study between the aforementioned boy with 46,XX testicular disorders of sex development and an age-matched patient with hydrocele testis (46,XY). During their consecutive surgeries, testicular biopsy specimens were obtained. Genes with differential expression compared with XY testis were identified using polymerase chain reaction (PCR)-based subtractive hybridization and sequencing. For validation of differential gene expression, real-time RT-PCR was performed using gene-specific primers. The distribution of candidate proteins in the testicular tissue was clarified by immunohistochemistry in human and rodent specimens. Moreover, in vitro inhibitory assays were performed. We identified 13 upregulated and 7 downregulated genes in XX testis. Among the candidate genes, we focused on ROCK1 (Rho-associated, coiled-coil protein kinase 1) in the upregulated gene group, because high expression in XX testis was validated by real-time RT-PCR. ROCK1 protein was detected in germ cells, Leydig cells, and Sertoli cells by immunohistochemistry. Moreover, the addition of specific ROCK1 inhibitor to Sertoli cells decreased SOX9 gene expression. On the basis of in vitro inhibitory assay, it is suggested that ROCK1 phosphorylates and activates SOX9 in Sertoli cells. Testes formation might be initiated by an alternative signaling pathway attributed to ROCK1, not SRY, activation in XX testes. Copyright © 2013 Elsevier Inc. All rights reserved.

  20. Overrepresentation of the ACTN3 XX genotype in elite canoe and kayak paddlers.

    PubMed

    Orysiak, Joanna; Sitkowski, Dariusz; Zmijewski, Piotr; Malczewska-Lenczowska, Jadwiga; Cieszczyk, Pawel; Zembron-Lacny, Agnieszka; Pokrywka, Andrzej

    2015-04-01

    The aim of the study was to examine the association between the ACTN3 R577X polymorphism in canoe sprint athletes (canoe and kayak paddlers) and their results at 200- or 1000-m distance. Eighty-six European white male athletes divided into 2 groups-successful, who were outstanding at national championships, and nonsuccessful in these competitions-and 354 nonathletic controls were included in this study. The R577X polymorphism of ACTN3 was typed using PCR-RFLP. ACTN3 genotype distribution among all tested athletes and controls was in Hardy-Weinberg equilibrium. The odds ratio (OR) for successful 1000-m athletes harboring the XX genotype compared with sedentary controls was 2.95 (95% confidence interval [CI]: 1.37-6.35), but the OR for nonsuccessful 200-m athletes having the XX genotype compared with controls was 2.64 (95% CI: 1.30-5.36). These results suggest that factors associated with the ACTN3 XX genotype in canoe and kayak paddlers might provide some competitive advantage in performance at 1000 m, but it seems to limit at 200 m. Further studies aimed at development of training strategies based on genetic factors are needed.

  1. The case of an Sry-negative XX male Pug with an inguinal gonad.

    PubMed

    Rota, A; Cucuzza, A Starvaggi; Iussich, S; Delorenzi, L; Parma, P

    2010-08-01

    A case of intersexuality in a Pug that was bought as a male in a pet shop is described. The dog was presented at the Veterinary Teaching Hospital, University of Turin, for a reddish mass protruding from the prepuce. The mass had the aspect of an enlarged clitoris, with a caudoventral direction and a dorsal urethral ostium. A gonad was palpable in the left inguinal region. Laparotomy confirmed ultrasound detection of an abdominal uterine structure together with the right gonad. The histology of both gonads was similar, showing an exclusively masculine character, with seminiferous tubules lined only by Sertoli cells; the uterus showed a normal histological structure. Karyological analysis revealed a female karyotype (78,XX), and polymerase chain reaction showed the absence of Sry. The diagnosis was an XX male. The pathogenesis of the XX sex reversal syndrome in dogs is not completely understood, as Sry, the master gene regulating testis differentiation, is not present; to date, no genetic cause has been identified for this phenotypic condition in dogs. This case is unusual because the dog showed an inguinal testis, implying a partial activity of the mechanisms leading to abdominal testis translocation along a gubernaculum and transinguinal migration.

  2. Intersexuality associated with XX/XY mosaicism in a horned goat.

    PubMed

    Bongso, T A; Thavalingam, M; Mukherjee, T K

    1982-01-01

    Anatomical, histological, and cytogenetic studies were undertaken on a horned intersex goat kid and three of its normal litter mates. The intersex had male type horns, male beard, vestigial mammary glands, female external genitalia, and an enlarged peniform clitoris, exuded a pungent male odor, had a male bleat, and came into estrus every 20 days. At laparotomy and subsequent slaughter, an ovotestes was observed on the right side and a testis and epididymal remnants on the left side. Uterine horn segments, cervix, vagina, and enlarged clitoris (2 cm) were also present. Histologically, spermatogenesis was not observed in either testis, but active Leydig cells were present. The ovary contained mature follicles. Chromosome analysis revealed 60XX/60XY cell populations in blood, bone marrow, and skin. Lymphocytic metaphases from the male and female cosibs showed single populations of 60XY and 60XX, respectively. Mosaicism associated with the horned condition in the intersex goat was established.

  3. Classroom Wall Charts and Biblical History: A Study of Educational Technology in Elementary Schools in Late Nineteenth- and Early Twentieth-Century Sweden

    ERIC Educational Resources Information Center

    Evertsson, Jakob

    2014-01-01

    This article considers the emergence of classroom wall charts as a teaching technology in Swedish elementary schools in the late nineteenth and early twentieth centuries, using Biblical history teaching as an example. There has been some work done internationally on wall charts as an instructional technology, but few studies have looked at their…

  4. [A case of 63,X/64,XX mosaicism in a subfertile pony mare].

    PubMed

    Pieńkowska-Schelling, A; Handler, J; Neuhauser, S; Schelling, C

    2016-04-01

    The present case report describes a 6-year old subfertile pony mare, which became pregnant after the eleventh artificial insemination. The examination of the ovaries and the uterus did not reveal any abnormal clinical findings and the mare showed a regular oestrous cycle. Based on cytogenetic and molecular genetic analyses it became possible to elucidate the observed subfertility. The mosaic karyotype of the mare consisted of 63,X (20%) and 64,XX (80%) cells. A PCR analysis failed to amplify sequences from the equine SRY gene. The observed classic 63,X/64,XX mosaicism is a plausible explanation for the subfertility of the mare.

  5. XX Disorder of Sex Development is associated with an insertion on chromosome 9 and downregulation of RSPO1 in dogs (Canis lupus familiaris).

    PubMed

    Meyers-Wallen, Vicki N; Boyko, Adam R; Danko, Charles G; Grenier, Jennifer K; Mezey, Jason G; Hayward, Jessica J; Shannon, Laura M; Gao, Chuan; Shafquat, Afrah; Rice, Edward J; Pujar, Shashikant; Eggers, Stefanie; Ohnesorg, Thomas; Sinclair, Andrew H

    2017-01-01

    Remarkable progress has been achieved in understanding the mechanisms controlling sex determination, yet the cause for many Disorders of Sex Development (DSD) remains unknown. Of particular interest is a rare XX DSD subtype in which individuals are negative for SRY, the testis determining factor on the Y chromosome, yet develop testes or ovotestes, and both of these phenotypes occur in the same family. This is a naturally occurring disorder in humans (Homo sapiens) and dogs (C. familiaris). Phenotypes in the canine XX DSD model are strikingly similar to those of the human XX DSD subtype. The purposes of this study were to identify 1) a variant associated with XX DSD in the canine model and 2) gene expression alterations in canine embryonic gonads that could be informative to causation. Using a genome wide association study (GWAS) and whole genome sequencing (WGS), we identified a variant on C. familiaris autosome 9 (CFA9) that is associated with XX DSD in the canine model and in affected purebred dogs. This is the first marker identified for inherited canine XX DSD. It lies upstream of SOX9 within the canine ortholog for the human disorder, which resides on 17q24. Inheritance of this variant indicates that XX DSD is a complex trait in which breed genetic background affects penetrance. Furthermore, the homozygous variant genotype is associated with embryonic lethality in at least one breed. Our analysis of gene expression studies (RNA-seq and PRO-seq) in embryonic gonads at risk of XX DSD from the canine model identified significant RSPO1 downregulation in comparison to XX controls, without significant upregulation of SOX9 or other known testis pathway genes. Based on these data, a novel mechanism is proposed in which molecular lesions acting upstream of RSPO1 induce epigenomic gonadal mosaicism.

  6. XX Disorder of Sex Development is associated with an insertion on chromosome 9 and downregulation of RSPO1 in dogs (Canis lupus familiaris)

    PubMed Central

    Boyko, Adam R.; Grenier, Jennifer K.; Mezey, Jason G.; Hayward, Jessica J.; Shannon, Laura M.; Gao, Chuan; Shafquat, Afrah; Rice, Edward J.; Eggers, Stefanie; Ohnesorg, Thomas; Sinclair, Andrew H.

    2017-01-01

    Remarkable progress has been achieved in understanding the mechanisms controlling sex determination, yet the cause for many Disorders of Sex Development (DSD) remains unknown. Of particular interest is a rare XX DSD subtype in which individuals are negative for SRY, the testis determining factor on the Y chromosome, yet develop testes or ovotestes, and both of these phenotypes occur in the same family. This is a naturally occurring disorder in humans (Homo sapiens) and dogs (C. familiaris). Phenotypes in the canine XX DSD model are strikingly similar to those of the human XX DSD subtype. The purposes of this study were to identify 1) a variant associated with XX DSD in the canine model and 2) gene expression alterations in canine embryonic gonads that could be informative to causation. Using a genome wide association study (GWAS) and whole genome sequencing (WGS), we identified a variant on C. familiaris autosome 9 (CFA9) that is associated with XX DSD in the canine model and in affected purebred dogs. This is the first marker identified for inherited canine XX DSD. It lies upstream of SOX9 within the canine ortholog for the human disorder, which resides on 17q24. Inheritance of this variant indicates that XX DSD is a complex trait in which breed genetic background affects penetrance. Furthermore, the homozygous variant genotype is associated with embryonic lethality in at least one breed. Our analysis of gene expression studies (RNA-seq and PRO-seq) in embryonic gonads at risk of XX DSD from the canine model identified significant RSPO1 downregulation in comparison to XX controls, without significant upregulation of SOX9 or other known testis pathway genes. Based on these data, a novel mechanism is proposed in which molecular lesions acting upstream of RSPO1 induce epigenomic gonadal mosaicism. PMID:29053721

  7. Interchromosomal insertional translocation at Xq26.3 alters SOX3 expression in an individual with XX male sex reversal.

    PubMed

    Haines, Bryan; Hughes, James; Corbett, Mark; Shaw, Marie; Innes, Josie; Patel, Leena; Gecz, Jozef; Clayton-Smith, Jill; Thomas, Paul

    2015-05-01

    46,XX male sex reversal occurs in approximately 1: 20 000 live births and is most commonly caused by interchromosomal translocations of the Y-linked sex-determining gene, SRY. Rearrangements of the closely related SOX3 gene on the X chromosome are also associated with 46,XX male sex reversal. It has been hypothesized that sex reversal in the latter is caused by ectopic expression of SOX3 in the developing urogenital ridge where it triggers male development by acting as an analog of SRY. However, altered regulation of SOX3 in individuals with XX male sex reversal has not been demonstrated. Here we report a boy with SRY-negative XX male sex reversal who was diagnosed at birth with a small phallus, mixed gonads, and borderline-normal T. Molecular characterization of the affected individual was performed using array comparative genomic hybridization, fluorescent in situ hybridization of metaphase chromosomes, whole-genome sequencing, and RT-PCR expression analysis of lymphoblast cell lines. The affected male carries ∼774-kb insertion translocation from chromosome 1 into a human-specific palindromic sequence 82 kb distal to SOX3. Importantly, robust SOX3 expression was identified in cells derived from the affected individual but not from control XX or XY cells, indicating that the translocation has a direct effect on SOX3 regulation. This is the first demonstration of altered SOX3 expression in an individual with XX male sex reversal and suggests that SOX3 can substitute for SRY to initiate male development in humans.

  8. Italian news coverage of radiation in the early decades of the twentieth century: A qualitative and quantitative analysis.

    PubMed

    Candela, Andrea; Pasquarè Mariotto, Federico

    2016-02-01

    This work uses a qualitative approach coupled with a quantitative software-based methodology to examine the Italian news media coverage of radiation in the early decades of the twentieth century. We analyze 80 news stories from two of the most influential Italian newspapers from that time: La Stampa (a daily newspaper) and La Domenica del Corriere (an Italian Sunday supplement). While much of previous research on media coverage of scientific topics was generally focused on present-day news, our work revolves around the ground-breaking discovery of X-rays and radioactivity at the dawn of the last century. Our analysis aims to identify journalistic frames in the news coverage of radiation that journalists might have used to emphasize the benefits (or the risks) of the new discoveries. We also hypothesize how this kind of news coverage might have influenced public perception of technological, commercial, and public health applications of the new scientific advancements. © The Author(s) 2014.

  9. Sox9 duplications are a relevant cause of Sry-negative XX sex reversal dogs.

    PubMed

    Rossi, Elena; Radi, Orietta; De Lorenzi, Lisa; Vetro, Annalisa; Groppetti, Debora; Bigliardi, Enrico; Luvoni, Gaia Cecilia; Rota, Ada; Camerino, Giovanna; Zuffardi, Orsetta; Parma, Pietro

    2014-01-01

    Sexual development in mammals is based on a complicated and delicate network of genes and hormones that have to collaborate in a precise manner. The dark side of this pathway is represented by pathological conditions, wherein sexual development does not occur properly either in the XX and the XY background. Among them a conundrum is represented by the XX individuals with at least a partial testis differentiation even in absence of SRY. This particular condition is present in various mammals including the dog. Seven dogs characterized by XX karyotype, absence of SRY gene, and testicular tissue development were analysed by Array-CGH. In two cases the array-CGH analysis detected an interstitial heterozygous duplication of chromosome 9. The duplication contained the SOX9 coding region. In this work we provide for the first time a causative mutation for the XXSR condition in the dog. Moreover this report supports the idea that the dog represents a good animal model for the study of XXSR condition caused by abnormalities in the SOX9 locus.

  10. [The development of idea of psychiatric care decentralization in late XIX - early XX centuries].

    PubMed

    2012-01-01

    The article demonstrates that over a period of many years the development of national psychiatric care in Russia followed the course of centralization. During the Zemstvo self government period the principle of decentralization was proposed on purpose to make the psychiatric care more accessible for population.

  11. Painful ovulation in a 46,XX SRY −ve adult male with SOX9 duplication

    PubMed Central

    Kean, Anne-Maree; Ewans, Lisa; Ohnesorg, Thomas; Ayers, Katie L; Watson, Geoff; Vasilaras, Arthur; Sinclair, Andrew H; Twigg, Stephen M; Handelsman, David J

    2017-01-01

    46,XX disorders of sexual development (DSDs) occur rarely and result from disruptions of the genetic pathways underlying gonadal development and differentiation. We present a case of a young phenotypic male with 46,XX SRY-negative ovotesticular DSD resulting from a duplication upstream of SOX9 presenting with a painful testicular mass resulting from ovulation into an ovotestis. We present a literature review of ovulation in phenotypic men and discuss the role of SRY and SOX9 in testicular development, including the role of SOX9 upstream enhancer region duplication in female-to-male sex reversal. Learning points: In mammals, the early gonad is bipotent and can differentiate into either a testis or an ovary. SRY is the master switch in testis determination, responsible for differentiation of the bipotent gonad into testis. SRY activates SOX9 gene, SOX9 as a transcription factor is the second major gene involved in male sex determination. SOX9 drives the proliferation of Sertoli cells and activates AMH/MIS repressing the ovary. SOX9 is sufficient to induce testis formation and can substitute for SRY function. Assessing karyotype and then determination of the presence or absence of Mullerian structures are necessary serial investigations in any case of DSD, except for mixed gonadal dysgenesis identified by karyotype alone. Treatment is ideal in a multidisciplinary setting with considerations to genetic (implications to family and reproductive recurrence risk), psychological aspects (sensitive individualized counseling including patient gender identity and preference), endocrinological (hormone replacement), surgical (cosmetic, prophylactic gonadectomy) fertility preservation and reproductive opportunities and metabolic health (cardiovascular and bones). PMID:28620497

  12. [Renal decapsulation for the treatment of anuria : A "forgotten" treatment from the early 20th century].

    PubMed

    Dräger, D L; Protzel, C; Hakenberg, O W

    2017-01-01

    In the early 20th century, Harrison first performed renal decapsulation in anuric children with scarlet fever and observed improvement in renal function postoperatively. The pathophysiological explanation was seen in intraparenchymal renal pressure due to edema which was improved by surgical decapsulation. The technique of decapsulation was simple excision after incision and blunt dissection of the renal parenchyma. Renal decapsulation then became a procedure commonly used for many indications in inflammatory renal conditions; indications were renal angioneurosis, hydronephrosis, toxic, bacterial and chronic nephritis, renal abscess and even eclampsia. With the beginning of the antibiotic era, renal decapsulation became obsolete and has disappeared from the urological spectrum completely.

  13. 46, XX true hermaphroditism associated with a terminal deletion of the short arm of the X chromosome

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barbaux, S.; Vilain, E.; McElreavey, K.

    1994-09-01

    Testes are determined by the activity of the SRY gene product encoded by the Y chromosome. Mutations in SRY can lead to XY sex reversal (XY females) and the presence of the SRY gene in some XX individuals can lead either to complete (XX males) or incomplete (XX true hermaphrodites) sex reversal. Approximately 10% of XX true hermaphrodites contain a portion of the Y chromosome, including SRY, in their genome. The etiology of the remaining cases is unestablished but may be caused by mutations in other as yet unidentied sex determining genes downstream of SRY. Here we describe an SRY-negativemore » true hermaphrodite with a 46,X,del(X)(p21.1-pter). The patient also presented with severe mental retardation, abnormal skin pigmentation and below average height. Histological examination of the gonad revealed bilateral ovotestis. We postulate that the Xp deletion has unmasked a recessive allele on the apparently normal X chromosome generating the intersex phenotype. This observation together with recent findings of certain XY females carrying duplications of Xp21.3 suggests that there may be a loci on Xp which acts as a switch in the testis/ovarian determination pathways.« less

  14. Intercultural Education by Governesses (Seventeenth to Twentieth Century)

    ERIC Educational Resources Information Center

    Hardach-Pinke, Irene

    2010-01-01

    One of the early forms of intercultural education was the upbringing of children by foreign governesses, who appeared on the European labour market during the seventeenth century. In Germany families of the gentry and the wealthy middle-classes began, since the eighteenth century, to copy the upbringing of princely children. They too wanted their…

  15. Incidence, prevalence, diagnostic delay, morbidity, mortality and socioeconomic status in males with 46,XX disorders of sex development: a nationwide study.

    PubMed

    Berglund, A; Johannsen, T H; Stochholm, K; Aksglaede, L; Fedder, J; Viuff, M H; Main, K M; Gravholt, C H

    2017-08-01

    What is the epidemiology and trajectory of health and socioeconomic status in males with 46,XX disorders of sex development (DSD)? 46,XX DSD males had an increased overall morbidity compared to male background population controls, and the socioeconomic status was inferior on outcome parameters such as education and long-term income. 46,XX DSD males are rare and estimates of prevalence and incidence are limited. An increased morbidity and mortality as well as a negatively affected socioeconomic status are described in males with Klinefelter Syndrome. However, this has never been systematically studied in 46,XX DSD males. In this nationwide registry study including 44 males with a verified diagnosis of 46,XX DSD we aimed to estimate incidence, prevalence and diagnostic delay. Further, we aimed to study morbidity, mortality and socioeconomic outcome parameters using the Danish registries. The socioeconomic outcome parameters were education, income, retirement, parenthood and cohabitation. 46,XX DSD males were born during 1908-2012 and follow-up started at birth or at start of registration and ended in 2014. Potential cases (n = 69) were identified in the Danish Cytogenetic Central Registry and the diagnosis was verified by medical record evaluation (n = 44). A randomly selected age-matched control group of 100 males and 100 females per case was identified by Statistics Denmark. Among newborn males the prevalence of diagnosed 46,XX DSD males was 3.5-4.7 per 100 000. Median age at diagnosis was 17.0 years (range: 0.0-62.8). Overall morbidity was increased compared to male controls (hazard ratio [HR] = 2.4, 95% CI: 1.8-3.3) but not when excluding endocrine and urogenital diseases as well as congenital malformations (HR = 1.2, 95% CI: 0.8-1.6). Mortality was not increased (HR = 0.6, 95% CI: 0.2-2.5) compared to male controls. 46,XX DSD males had poorer education (HR = 0.1, 95% CI: 0.0-0.9) and fewer fatherhoods (HR = 0.4, 95% CI: 0.2-0.7) than male controls

  16. Early meteorological records from Latin-America and the Caribbean during the 18th and 19th centuries

    NASA Astrophysics Data System (ADS)

    Domínguez-Castro, Fernando; Vaquero, José Manuel; Gallego, María Cruz; Farrona, Ana María Marín; Antuña-Marrero, Juan Carlos; Cevallos, Erika Elizabeth; Herrera, Ricardo García; de La Guía, Cristina; Mejía, Raúl David; Naranjo, José Manuel; Del Rosario Prieto, María; Ramos Guadalupe, Luis Enrique; Seiner, Lizardo; Trigo, Ricardo Machado; Villacís, Marcos

    2017-11-01

    This paper provides early instrumental data recovered for 20 countries of Latin-America and the Caribbean (Argentina, Bahamas, Belize, Brazil, British Guiana, Chile, Colombia, Costa Rica, Cuba, Ecuador, France (Martinique and Guadalupe), Guatemala, Jamaica, Mexico, Nicaragua, Panama, Peru, Puerto Rico, El Salvador and Suriname) during the 18th and 19th centuries. The main meteorological variables retrieved were air temperature, atmospheric pressure, and precipitation, but other variables, such as humidity, wind direction, and state of the sky were retrieved when possible. In total, more than 300,000 early instrumental data were rescued (96% with daily resolution). Especial effort was made to document all the available metadata in order to allow further post-processing. The compilation is far from being exhaustive, but the dataset will contribute to a better understanding of climate variability in the region, and to enlarging the period of overlap between instrumental data and natural/documentary proxies.

  17. Early meteorological records from Latin-America and the Caribbean during the 18th and 19th centuries

    PubMed Central

    Domínguez-Castro, Fernando; Vaquero, José Manuel; Gallego, María Cruz; Farrona, Ana María Marín; Antuña-Marrero, Juan Carlos; Cevallos, Erika Elizabeth; Herrera, Ricardo García; de la Guía, Cristina; Mejía, Raúl David; Naranjo, José Manuel; del Rosario Prieto, María; Ramos Guadalupe, Luis Enrique; Seiner, Lizardo; Trigo, Ricardo Machado; Villacís, Marcos

    2017-01-01

    This paper provides early instrumental data recovered for 20 countries of Latin-America and the Caribbean (Argentina, Bahamas, Belize, Brazil, British Guiana, Chile, Colombia, Costa Rica, Cuba, Ecuador, France (Martinique and Guadalupe), Guatemala, Jamaica, Mexico, Nicaragua, Panama, Peru, Puerto Rico, El Salvador and Suriname) during the 18th and 19th centuries. The main meteorological variables retrieved were air temperature, atmospheric pressure, and precipitation, but other variables, such as humidity, wind direction, and state of the sky were retrieved when possible. In total, more than 300,000 early instrumental data were rescued (96% with daily resolution). Especial effort was made to document all the available metadata in order to allow further post-processing. The compilation is far from being exhaustive, but the dataset will contribute to a better understanding of climate variability in the region, and to enlarging the period of overlap between instrumental data and natural/documentary proxies. PMID:29135974

  18. Early meteorological records from Latin-America and the Caribbean during the 18th and 19th centuries.

    PubMed

    Domínguez-Castro, Fernando; Vaquero, José Manuel; Gallego, María Cruz; Farrona, Ana María Marín; Antuña-Marrero, Juan Carlos; Cevallos, Erika Elizabeth; Herrera, Ricardo García; de la Guía, Cristina; Mejía, Raúl David; Naranjo, José Manuel; Del Rosario Prieto, María; Ramos Guadalupe, Luis Enrique; Seiner, Lizardo; Trigo, Ricardo Machado; Villacís, Marcos

    2017-11-14

    This paper provides early instrumental data recovered for 20 countries of Latin-America and the Caribbean (Argentina, Bahamas, Belize, Brazil, British Guiana, Chile, Colombia, Costa Rica, Cuba, Ecuador, France (Martinique and Guadalupe), Guatemala, Jamaica, Mexico, Nicaragua, Panama, Peru, Puerto Rico, El Salvador and Suriname) during the 18th and 19th centuries. The main meteorological variables retrieved were air temperature, atmospheric pressure, and precipitation, but other variables, such as humidity, wind direction, and state of the sky were retrieved when possible. In total, more than 300,000 early instrumental data were rescued (96% with daily resolution). Especial effort was made to document all the available metadata in order to allow further post-processing. The compilation is far from being exhaustive, but the dataset will contribute to a better understanding of climate variability in the region, and to enlarging the period of overlap between instrumental data and natural/documentary proxies.

  19. National Gender Policy in Public Education in the Russian Empire in the Latter Half of the 19th-Early 20th Centuries

    ERIC Educational Resources Information Center

    Saifullova, Razilia Rauilovna; Maslova, Inga Vladimirovna; Krapotkina, Irina Evgenevna; Kaviev, Airat Farkhatovich; Nasyrova, Liliya Gabdelvalievna

    2016-01-01

    This article presents the national gender policy in public education in the Russian Empire in the latter half of the 19th-early 20th centuries. In the course of work the authors have used special historical research methods enabling to hammer out the facts and to approach historical sources from a critical standpoint. The comparative method…

  20. Development of Formal Agricultural Education in Canada (Based on the Analysis of Scientific Periodicals of the 19th-Early 20th Centuries)

    ERIC Educational Resources Information Center

    Havrylenko, Kateryna

    2016-01-01

    The article states that one of the world leaders in agricultural sector training is Canada, which has gained a great scientific and practical experience. The paper examines the role of periodicals of the 19th-early 20th centuries, preserved in the Canadian book funds for the establishment and development of formal agricultural education of this…

  1. Mutation of foxl2 or cyp19a1a Results in Female to Male Sex Reversal in XX Nile Tilapia.

    PubMed

    Zhang, Xianbo; Li, Mengru; Ma, He; Liu, Xingyong; Shi, Hongjuan; Li, Minghui; Wang, Deshou

    2017-08-01

    It is well accepted that Forkhead box protein L2 (Foxl2) and aromatase (Cyp19a1; the enzyme responsible for estrogen synthesis) are critical for ovarian development in vertebrates. Knockouts of Foxl2 and Cyp19a1 in goat, mouse, and zebrafish have revealed similar but not identical functions across species. Functional analyses of these two genes in other animals are needed to elucidate their conserved roles in vertebrate sexual development. In this study, we established foxl2 and cyp19a1a mutant lines in Nile tilapia. Both foxl2-/- and cyp19a1a-/- XX fish displayed female-to-male sex reversal. Sf1, Dmrt1, and Gsdf were upregulated in the foxl2-/- and the cyp19a1a-/- XX gonads. Downregulation of Cyp19a1a and serum estradiol-17β level, and upregulation of Cyp11b2 and serum 11-ketotestosterone level were observed in foxl2-/- XX fish. The mutant phenotype of foxl2-/- XX individuals could be rescued by 17β-estradiol treatment from 5 to 30 days after hatching (dah). Upregulation of Star1, the enzyme involved in androgen production in tilapia, was also observed in the foxl2-/- XX gonad at 30 and 90 dah. In vitro promoter analyses consistently demonstrated that Foxl2 could suppress the transcription of star1 in a dose-dependent manner. In addition, compared with the control XX gonad, fewer germ cells were detected in the foxl2-/- XX, cyp19a1a-/- XX, and control XY gonads 10 dah. These results demonstrate that Foxl2 promotes ovarian development by upregulating Cyp19a1a expression and repressing male pathway gene expression. These results extend the study of Foxl2 and Cyp19a1a loss of function to a commercially important fish species. Copyright © 2017 Endocrine Society.

  2. Crown heights in the permanent teeth of 45,X and 45,X/46,XX females.

    PubMed

    Pentinpuro, Raija Helena; Lähdesmäki, Raija Eliisa; Niinimaa, Ahti Olavi; Pesonen, Paula Ritva Orvokki; Alvesalo, Lassi Juhani

    2014-11-01

    Previous results regarding human sex chromosome aneuploidies have shown that the X and Y chromosomes affect tooth size and morphology. This study looked for the effect of sex chromosome deficiency on permanent tooth crown heights. The material, from the Finnish KVANTTI Research Project, consisted of 97 45,X females and 15 45,X/46,XX females. The controls were 32 sisters and 28 mothers of the 45,X females, eight sisters and two mothers of the 45,X/46,XX females and 35 female population controls. Crown heights of all the available teeth except third molars on both sides of the jaws were measured from panoramic radiographs with a digital calliper according to the defined procedure. The tooth crown heights were significantly smaller in the 45,X females than in the female population controls, except for the incisors and one canine in the maxilla, whereas the tooth crown heights of the 45,X/46,XX females were close to those of the normal control females. The differences between the 45,X and 45,X/46,XX females were statistically significant, excluding the upper incisor area and a few teeth in the mandible. The effect of the sex chromosome deficiency on permanent tooth crown height is due to the magnitude of lacking sex chromosome material. The present results regarding the 45,X females are parallel to previous findings in Turner patients regarding reduced mesiodistal and labiolingual dimensions and tooth crown heights in the permanent dentition.

  3. Defining a discovery: priority and methodological controversy in early nineteenth-century anatomy

    PubMed Central

    Berkowitz, Carin

    2014-01-01

    In the early nineteenth century, Charles Bell and François Magendie engaged in a decades-long priority dispute over the discovery of the roots of motor and sensory nerves. The constantly recalibrated arguments of its participants illuminate changes in the life sciences during that period. When Bell first wrote about the nerves in 1811, surgeon-anatomists ran small schools out of their homes, natural theology was in vogue, exchanges between British and French medical practitioners were limited by the Napoleonic Wars, and British practitioners typically rejected experimental physiology and vivisection. By the end of Magendie's career, medical science was produced in the laboratory, taught through artfully produced performances of the sort at which Magendie excelled, and disseminated through journals. It is not entirely clear which historical character, Bell or Magendie, ‘won’ the dispute, nor that they even had clear and consistent positions in it, but what is clear is that one style of science had won out over the other, and over the course of the dispute, pedagogy lost pride of place in medical science. PMID:27494015

  4. Ancient DNA identification of early 20th century simian T-cell leukemia virus type 1.

    PubMed

    Calvignac, Sébastien; Terme, Jean-Michel; Hensley, Shannon M; Jalinot, Pierre; Greenwood, Alex D; Hänni, Catherine

    2008-06-01

    The molecular identification of proviruses from ancient tissues (and particularly from bones) remains a contentious issue. It can be expected that the copy number of proviruses will be low, which magnifies the risk of contamination with retroviruses from exogenous sources. To assess the feasibility of paleoretrovirological studies, we attempted to identify proviruses from early 20th century bones of museum specimens while following a strict ancient DNA methodology. Simian T-cell leukemia virus type 1 sequences were successfully obtained and authenticated from a Chlorocebus pygerythrus specimen. This represents the first clear evidence that it will be possible to use museum specimens to better characterize simian and human T-tropic retrovirus genetic diversity and analyze their origin and evolution, in greater detail.

  5. CHANGES in SKIN TANNING ATTITUDES Fashion Articles and Advertisements in the Early 20th Century

    PubMed Central

    Martin, Jo M.; Ghaferi, Jessica M.; Cummins, Deborah L.; Mamelak, Adam J.; Schmults, Chrys D.; Parikh, Mona; Speyer, Lark-Aeryn; Chuang, Alice; Richardson, Hazel V.; Stein, David

    2009-01-01

    Historical reviews suggest that tanning first became fashionable in the 1920s or 1930s. To quantitatively and qualitatively examine changes in tanning attitudes portrayed in the popular women's press during the early 20th century, we reviewed summer issues of Vogue and Harper's Bazaar for the years 1920, 1927, 1928, and 1929. We examined these issues for articles and advertisements promoting skin tanning or skin bleaching and protection. We found that articles and advertisements promoting the fashionable aspects of tanned skin were more numerous in 1928 and 1929 than in 1927 and 1920, whereas those promoting pale skin (by bleaching or protection) were less numerous. These findings demonstrate a clear shift in attitudes toward tanned skin during this period. PMID:19846688

  6. Changes in skin tanning attitudes. Fashion articles and advertisements in the early 20th century.

    PubMed

    Martin, Jo M; Ghaferi, Jessica M; Cummins, Deborah L; Mamelak, Adam J; Schmults, Chrys D; Parikh, Mona; Speyer, Lark-Aeryn; Chuang, Alice; Richardson, Hazel V; Stein, David; Liégeois, Nanette J

    2009-12-01

    Historical reviews suggest that tanning first became fashionable in the 1920s or 1930s. To quantitatively and qualitatively examine changes in tanning attitudes portrayed in the popular women's press during the early 20th century, we reviewed summer issues of Vogue and Harper's Bazaar for the years 1920, 1927, 1928, and 1929. We examined these issues for articles and advertisements promoting skin tanning or skin bleaching and protection. We found that articles and advertisements promoting the fashionable aspects of tanned skin were more numerous in 1928 and 1929 than in 1927 and 1920, whereas those promoting pale skin (by bleaching or protection) were less numerous. These findings demonstrate a clear shift in attitudes toward tanned skin during this period.

  7. Methylation Patterns of SOX3, SOX9, and WNT4 Genes in Gonads of Dogs with XX (SRY-Negative) Disorder of Sexual Development.

    PubMed

    Salamon, Sylwia; Flisikowski, Krzysztof; Switonski, Marek

    2017-01-01

    Ovotesticular or testicular disorder of sexual development in dogs with female karyotype and lack of SRY (XX DSD) is a common sexual anomaly diagnosed in numerous breeds. The molecular background, however, remains unclear, and epigenetic mechanisms, including DNA methylation, have not been studied. The aim of our study was comparative methylation analysis of CpG islands in promoters of candidate genes for XX DSD: SOX9, SOX3, and WNT4. Methylation studies were performed on DNA extracted from formalin-fixed/paraffin-embedded or frozen gonads from 2 dogs with ovotesticular and 2 dogs with testicular XX DSD as well as control females (n = 4) and males (n = 2). Bisulfite-converted DNA was used for CpG methylation analysis using quantitative pyrosequencing. Promoter regions of SOX9 and WNT4 showed similar CpG methylation in each group, ranging from 0 to 5.5% and from 39 to 74%, respectively. The SOX3 promoter showed significantly higher methylation in the ovotesticular XX DSD cases and the testicular XX DSD and control males, suggesting that SOX3 methylation may play a role in canine XX DSD pathogenesis. © 2017 S. Karger AG, Basel.

  8. Geopolitics of Strategic Minerals: The Example of Chromium.

    DTIC Science & Technology

    1984-08-20

    to Jesus Christ, who created me; to my Dad, Dick, who molded me into the man I am today; to my Mom, Jane, from who I inherited the ability to do this...21st Century Research)3 XX Fine 4 XX Shabad 5 XX Vogely6 XX Strishkov ( BOM )7 XX Bowman8 XX Shafer9 xx Rees (Institute for the study of Conflict...to 56.1 percent in just five years. 4 WORLD MARKET OUTLOOK FOR CHROMIUM General agreement seems to occur among the BOM and independent authors on the

  9. Learning to File: Reconfiguring Information and Information Work in the Early Twentieth Century.

    PubMed

    Robertson, Craig

    2017-01-01

    This article uses textbooks and advertisements to explore the formal and informal ways in which people were introduced to vertical filing in the early twentieth century. Through the privileging of "system" an ideal mode of paperwork emerged in which a clerk could "grasp" information simply by hand without having to understand or comprehend its content. A file clerk's hands and fingers became central to the representation and teaching of filing. In this way, filing offered an example of a distinctly modern form of information work. Filing textbooks sought to enhance dexterity as the rapid handling of paper came to represent information as something that existed in discrete units, in bits that could be easily extracted. Advertisements represented this mode of information work in its ideal form when they frequently erased the worker or reduced him or her to hands, as "instant" filing became "automatic" filing, with the filing cabinet presented as a machine.

  10. Jean-Louis Brachet (1789-1858). A forgotten contributor to early 19th century neurology.

    PubMed

    Walusinski, O

    2015-10-01

    Specialists of the history of hysteria know the name of Jean-Louis Brachet (1789-1858), but few realise the influence of this physician and surgeon from Lyon, a city in the southeastern part of France. Not only a clinician, he was also a neurophysiology researcher in the early 19th century. Along with his descriptions of meningoencephalitis, including hydrocephalus and meningoencephalitis, he elucidated the functioning of the vegetative nervous system and described its activity during emotional states. He also helped describe the different forms of epilepsy and sought to understand their aetiologies, working at the same time as the better-known Louis-Florentin Calmeil (1798-1895). We present a biography of this forgotten physician, a prolific writer, keen clinical observer and staunch devotee of a rigorous scientific approach. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  11. Radiotherapy for Early-Stage Hodgkin's Lymphoma: A 21st Century Perspective and Review of Multiple Randomized Clinical Trials

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bar Ad, Voichita; Paltiel, Ora; Glatstein, Eli

    2008-12-01

    The treatment of Hodgkin's lymphoma has improved dramatically over the past decades. Over the last half century, Hodgkin's lymphoma has become one of the most curable cancers of adulthood. More than 90% of the patients with localized stages of the disease can be cured with modern treatment strategies. Long-term toxicities are now the major concern for survivors of early-stage disease. Contemporary therapeutic approaches for Hodgkin's lymphoma attempt to preserve the high cure rate achieved, while reducing treatment-related acute and late toxicities. The aim of this review is to re-examine the historical and the current role of radiotherapy for early-stage Hodgkin'smore » lymphoma, given the latest evidence of an increasing role of chemotherapy for the treatment of this malignancy. The literature search was performed in PubMed Plus. Studies on children were excluded.« less

  12. Finding Federal Money for Children's Services: Financing Services for Children through Title XX and Other Programs. Manual 1.

    ERIC Educational Resources Information Center

    Copeland, William C.

    This is the first manual of a 4-part series on how to find, obtain, contract for and manage Federal money for children's services. The first manual concentrates on ways to locate funds for new and existing programs. Emphasis is on Title XX of the Social Security Act, but attention is given also to alternative sources where Title XX funds are not…

  13. 40 CFR Table 1 to Subpart Xx of... - Hazardous Air Pollutants

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 11 2013-07-01 2013-07-01 false Hazardous Air Pollutants 1 Table 1 to Subpart XX of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED...

  14. 40 CFR Table 1 to Subpart Xx of... - Hazardous Air Pollutants

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Hazardous Air Pollutants 1 Table 1 to Subpart XX of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED...

  15. 40 CFR Table 1 to Subpart Xx of... - Hazardous Air Pollutants

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 10 2011-07-01 2011-07-01 false Hazardous Air Pollutants 1 Table 1 to Subpart XX of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED...

  16. Historical Analyses of Disordered Handwriting: Perspectives on Early 20th-Century Material From a German Psychiatric Hospital.

    PubMed

    Schiegg, Markus; Thorpe, Deborah

    2017-01-01

    Handwritten texts carry significant information, extending beyond the meaning of their words. Modern neurology, for example, benefits from the interpretation of the graphic features of writing and drawing for the diagnosis and monitoring of diseases and disorders. This article examines how handwriting analysis can be used, and has been used historically, as a methodological tool for the assessment of medical conditions and how this enhances our understanding of historical contexts of writing. We analyze handwritten material, writing tests and letters, from patients in an early 20th-century psychiatric hospital in southern Germany (Irsee/Kaufbeuren). In this institution, early psychiatrists assessed handwriting features, providing us novel insights into the earliest practices of psychiatric handwriting analysis, which can be connected to Berkenkotter's research on medical admission records. We finally consider the degree to which historical handwriting bears semiotic potential to explain the psychological state and personality of a writer, and how future research in written communication should approach these sources.

  17. [Antônio Moniz de Souza, the 'Man of Brazilian Nature': science and medicinal plants in the early 19th century].

    PubMed

    dos Santos, Laura Carvalho

    2008-01-01

    Early nineteenth century Brazil saw a vibrant movement to study nature, including a number of expeditions aimed at gathering a corpus of knowledge on Brazilian flora. One of the main goals of these expeditions was to map and identify plant species of economic and therapeutic value. The government undertook and sponsored various initiatives, and it was within this context that the Bahian voyager Antônio Moniz de Souza engaged in his activities. He traveled through areas of the Brazilian territory in the first decades of the nineteenth century, observing, cataloging, and collecting products from the three kingdoms, especially plants with medicinal powers. This study of Moniz de Souza pinpoints and analyzes important features in the exploration of nature and knowledge and the use of medicinal plants during this timeframe.

  18. Nelson's wound: treatment of spinal cord injury in 19th and early 20th century military conflicts.

    PubMed

    Hanigan, William C; Sloffer, Chris

    2004-01-15

    During the first half of the 19th century, warfare did not provide a background for a systematic analysis of spinal cord injury (SCI). Medical officers participating in the Peninsular and Crimean Wars emphasized the dismal prognosis of this injury, although authors of sketchy civil reports persuaded a few surgeons to operate on closed fractures. The American Medical and Surgical History of the War of the Rebellion was the first text to provide summary of results in 642 cases of gunshot wounds of the spine. The low incidence of this injury (0.26%) and the high mortality rate (55%) discouraged the use of surgery in these cases. Improvements in diagnoses and the introduction of x-ray studies in the latter half of the century enabled Sir G. H. Makins, during the Boer War, to recommend delayed intervention to remove bone or bullet fragments in incomplete injuries. The civil experiences of Elsberg and Frazier in the early 20th century promoted a meticulous approach to treatments, whereas efficient transport of injured soldiers during World War I increased the numbers of survivors. Open large wounds or cerebrospinal fluid leakage, signs of cord compression in recovering patients, delayed clinical deterioration, or intractable pain required surgical exploration. Wartime recommendations for urological and skin care prevented sepsis, and burgeoning pension systems provided specialized longterm rehabilitation. By the Armistice, the effective surgical treatment and postoperative care that had developed through decades of interaction between civil and military medicine helped reduce incidences of morbidity and dispel the hopelessness surrounding the combatant with an SCI.

  19. Traditions and Reforms in Bulgarian Physics Milko Borissov (1921-1998)

    NASA Astrophysics Data System (ADS)

    Kamisheva, Ganka

    2010-01-01

    University physics in Bulgaria is examined comparatively. Physical chairs, courses, lecturers and students, finished Sofia University successfully, are analyzed quantitatively. Traditions in Experimental physics are traced into scientific results of Professors P. Bachmetjew, A. Christow, and G. Nadjakov during the first half of XX century. Professor Milko Borissov's reformations of University physics in the second half of XX century are analysed.

  20. Medical confidentiality in the late nineteenth and early twentieth centuries: an Anglo-German comparison1

    PubMed Central

    2012-01-01

    Summary Professional secrecy of doctors became an issue of considerable medico-legal and political debate in the late nineteenth and early twentieth centuries in both Germany and England, although the legal preconditions for this debate were quite different in the two countries. While in Germany medical confidentiality was a legal obligation and granted in court, no such statutory recognition of doctors’ professional secrecy existed in England. This paper is a comparative analysis of medical secrecy in three key areas - divorce trials, venereal disease and abortion - in both countries. Based on sources from the period between c.1870 and 1939, our paper shows how doctors tried to define the scope of professional secrecy as an integral part of their professional honour in relation to important matters of public health. PMID:21077462

  1. Emergence of a utopian vision of modernist and futuristic houses and cities in early 20th century

    NASA Astrophysics Data System (ADS)

    Ma, Nan

    2017-04-01

    Throughout the development of literature on urban design theories, utopian thinking has played a crucial role as utopians were among the first designers. Many unrealized utopian projects such as The Radiant City, have presented a research laboratory and positive attempts for all architects, urban designers and theorists. In this essay, a utopian vision following under More’s and Jameson’s definitions is discussed, examining how the utopian vision of modernist and futuristic houses and cities emerged in the early twentieth century in response to several factors, what urban utopia aimed to represent, and how such version was represented in the built form and the urban landscapes.

  2. NR5A1 is a novel disease gene for 46,XX testicular and ovotesticular disorders of sex development.

    PubMed

    Baetens, Dorien; Stoop, Hans; Peelman, Frank; Todeschini, Anne-Laure; Rosseel, Toon; Coppieters, Frauke; Veitia, Reiner A; Looijenga, Leendert H J; De Baere, Elfride; Cools, Martine

    2017-04-01

    We aimed to identify the genetic cause in a cohort of 11 unrelated cases and two sisters with 46,XX SRY-negative (ovo)testicular disorders of sex development (DSD). Whole-exome sequencing (n = 9), targeted resequencing (n = 4), and haplotyping were performed. Immunohistochemistry of sex-specific markers was performed on patients' gonads. The consequences of mutation were investigated using luciferase assays, localization studies, and RNA-seq. We identified a novel heterozygous NR5A1 mutation, c.274C>T p.(Arg92Trp), in three unrelated patients. The Arg92 residue is highly conserved and located in the Ftz-F1 region, probably involved in DNA-binding specificity and stability. There were no consistent changes in transcriptional activation or subcellular localization. Transcriptomics in patient-derived lymphocytes showed upregulation of MAMLD1, a direct NR5A1 target previously associated with 46,XY DSD. In gonads of affected individuals, ovarian FOXL2 and testicular SRY-independent SOX9 expression observed. We propose NR5A1, previously associated with 46,XY DSD and 46,XX primary ovarian insufficiency, as a novel gene for 46,XX (ovo)testicular DSD. We hypothesize that p.(Arg92Trp) results in decreased inhibition of the male developmental pathway through downregulation of female antitestis genes, thereby tipping the balance toward testicular differentiation in 46,XX individuals. In conclusion, our study supports a role for NR5A1 in testis differentiation in the XX gonad.Genet Med 19 4, 367-376.

  3. Crystal structure of the second fibronectin type III (FN3) domain from human collagen α1 type XX.

    PubMed

    Zhao, Jingfeng; Ren, Jixia; Wang, Nan; Cheng, Zhong; Yang, Runmei; Lin, Gen; Guo, Yi; Cai, Dayong; Xie, Yong; Zhao, Xiaohong

    2017-12-01

    Collagen α1 type XX, which contains fibronectin type III (FN3) repeats involving six FN3 domains (referred to as the FN#1-FN#6 domains), is an unusual member of the fibril-associated collagens with interrupted triple helices (FACIT) subfamily of collagens. The results of standard protein BLAST suggest that the FN3 repeats might contribute to collagen α1 type XX acting as a cytokine receptor. To date, solution NMR structures of the FN#3, FN#4 and FN#6 domains have been determined. To obtain further structural evidence to understand the relationship between the structure and function of the FN3 repeats from collagen α1 type XX, the crystal structure of the FN#2 domain from human collagen α1 type XX (residues Pro386-Pro466; referred to as FN2-HCXX) was solved at 2.5 Å resolution. The crystal structure of FN2-HCXX shows an immunoglobulin-like fold containing a β-sandwich structure, which is formed by a three-stranded β-sheet (β1, β2 and β5) packed onto a four-stranded β-sheet (β3, β4, β6 and β7). Two consensus domains, tencon and fibcon, are structural analogues of FN2-HCXX. Fn8, an FN3 domain from human oncofoetal fibronectin, is the closest structural analogue of FN2-HCXX derived from a naturally occurring sequence. Based solely on the structural similarity of FN2-HCXX to other FN3 domains, the detailed functions of FN2-HCXX and the FN3 repeats in collagen α1 type XX cannot be identified.

  4. XX/XY Sex Chromosomes in the South American Dwarf Gecko (Gonatodes humeralis).

    PubMed

    Gamble, Tony; McKenna, Erin; Meyer, Wyatt; Nielsen, Stuart V; Pinto, Brendan J; Scantlebury, Daniel P; Higham, Timothy E

    2018-05-11

    Sex-specific genetic markers identified using restriction site-associated DNA sequencing, or RADseq, permits the recognition of a species' sex chromosome system in cases where standard cytogenetic methods fail. Thus, species with male-specific RAD markers have an XX/XY sex chromosome system (male heterogamety) while species with female-specific RAD markers have a ZZ/ZW sex chromosome (female heterogamety). Here, we use RADseq data from 5 male and 5 female South American dwarf geckos (Gonatodes humeralis) to identify an XX/XY sex chromosome system. This is the first confidently known sex chromosome system in a Gonatodes species. We used a low-coverage de novo G. humeralis genome assembly to design PCR primers to validate the male-specificity of a subset of the sex-specific RADseq markers and describe how even modest genome assemblies can facilitate the design of sex-specific PCR primers in species with diverse sex chromosome systems.

  5. Recent Anthologies of Eighteenth-Century Russian Literature: A Review Article.

    ERIC Educational Resources Information Center

    Edgerton, William B.

    1968-01-01

    Harold Segel's recently published anthology of eighteenth-century Russian literature in English is compared with the Soviet anthologies of Gukovskij and Kokorev (in Russian), the Polish anthology of Jakubowski (in Russian with Polish notes), and the early nineteenth-century Wiener anthology (in English). All of these works are described in some…

  6. Scientific Instruments for Education in Early Twentieth-Century Spain

    ERIC Educational Resources Information Center

    Ruiz-Castell, Pedro

    2008-01-01

    1898 marked a crucial point in the end of the nineteenth-century Spanish crisis. The military defeat ending the Spanish-American War was seen as proof that the country was in terminal decline. With the ideals of regeneration spreading throughout Spanish society, the State became more interested in supporting and sponsoring science and technology,…

  7. FGF9, activin and TGFβ promote testicular characteristics in an XX gonad organ culture model.

    PubMed

    Gustin, Sonja E; Stringer, Jessica M; Hogg, Kirsten; Sinclair, Andrew H; Western, Patrick S

    2016-11-01

    Testis development is dependent on the key sex-determining factors SRY and SOX9, which activate the essential ligand FGF9. Although FGF9 plays a central role in testis development, it is unable to induce testis formation on its own. However, other growth factors, including activins and TGFβs, also present testis during testis formation. In this study, we investigated the potential of FGF9 combined with activin and TGFβ to induce testis development in cultured XX gonads. Our data demonstrated differing individual and combined abilities of FGF9, activin and TGFβ to promote supporting cell proliferation, Sertoli cell development and male germ line differentiation in cultured XX gonads. FGF9 promoted proliferation of supporting cells in XX foetal gonads at rates similar to those observed in vivo during testis cord formation in XY gonads but was insufficient to initiate testis development. However, when FGF9, activin and TGFβ were combined, aspects of testicular development were induced, including the expression of Sox9, morphological reorganisation of the gonad and deposition of laminin around germ cells. Enhancing β-catenin activity diminished the testis-promoting activities of the combined growth factors. The male promoting activity of FGF9 and the combined growth factors directly or indirectly extended to the germ line, in which a mixed phenotype was observed. FGF9 and the combined growth factors promoted male germ line development, including mitotic arrest, but expression of pluripotency genes was maintained, rather than being repressed. Together, our data provide evidence that combined signalling by FGF9, activin and TGFβ can induce testicular characteristics in XX gonads. © 2016 Society for Reproduction and Fertility.

  8. Determinant representations of spin-operator matrix elements in the XX spin chain and their applications

    NASA Astrophysics Data System (ADS)

    Wu, Ning

    2018-01-01

    For the one-dimensional spin-1/2 XX model with either periodic or open boundary conditions, it is shown by using a fermionic approach that the matrix element of the spin operator Sj- (Sj-Sj'+ ) between two eigenstates with numbers of excitations n and n +1 (n and n ) can be expressed as the determinant of an appropriate (n +1 )×(n +1 ) matrix whose entries involve the coefficients of the canonical transformations diagonalizing the model. In the special case of a homogeneous periodic XX chain, the matrix element of Sj- reduces to a variant of the Cauchy determinant that can be evaluated analytically to yield a factorized expression. The obtained compact representations of these matrix elements are then applied to two physical scenarios: (i) Nonlinear optical response of molecular aggregates, for which the determinant representation of the transition dipole matrix elements between eigenstates provides a convenient way to calculate the third-order nonlinear responses for aggregates from small to large sizes compared with the optical wavelength; and (ii) real-time dynamics of an interacting Dicke model consisting of a single bosonic mode coupled to a one-dimensional XX spin bath. In this setup, full quantum calculation up to N ≤16 spins for vanishing intrabath coupling shows that the decay of the reduced bosonic occupation number approaches a finite plateau value (in the long-time limit) that depends on the ratio between the number of excitations and the total number of spins. Our results can find useful applications in various "system-bath" systems, with the system part inhomogeneously coupled to an interacting XX chain.

  9. Influence of Western European Pedagogical Trends on Development of Young Teachers' Pedagogical Mastery in the Late 19th-the Early 20th Centuries

    ERIC Educational Resources Information Center

    Trynus, Olena

    2018-01-01

    The end of the 19th and early 20th centuries is characterized by justification of reforming pedagogical trends in Western Europe and accumulation of relevant ideas required to create a new type of school, educate independent and initiative individuals and improve teacher training. Based on comparative pedagogical analysis of the mentioned period,…

  10. The Trouble with Title XX: A Review of Child Daycare Policy.

    ERIC Educational Resources Information Center

    Morgan, Gwen G.

    This discussion of government policy concerning child day care calls for a shift from provider-oriented to consumer-oriented services funded under Title XX of the Social Security Amendments. Three general views of child day care are described: the social services view, the school-oriented view, and a newer, parent-supportive, consumer-oriented…

  11. NR5A1 is a novel disease gene for 46,XX testicular and ovotesticular disorders of sex development

    PubMed Central

    Baetens, Dorien; Stoop, Hans; Peelman, Frank; Todeschini, Anne-Laure; Rosseel, Toon; Coppieters, Frauke; Veitia, Reiner A.; Looijenga, Leendert H.J.; De Baere, Elfride; Cools, Martine

    2017-01-01

    Purpose: We aimed to identify the genetic cause in a cohort of 11 unrelated cases and two sisters with 46,XX SRY-negative (ovo)testicular disorders of sex development (DSD). Methods: Whole-exome sequencing (n = 9), targeted resequencing (n = 4), and haplotyping were performed. Immunohistochemistry of sex-specific markers was performed on patients' gonads. The consequences of mutation were investigated using luciferase assays, localization studies, and RNA-seq. Results: We identified a novel heterozygous NR5A1 mutation, c.274C>T p.(Arg92Trp), in three unrelated patients. The Arg92 residue is highly conserved and located in the Ftz-F1 region, probably involved in DNA-binding specificity and stability. There were no consistent changes in transcriptional activation or subcellular localization. Transcriptomics in patient-derived lymphocytes showed upregulation of MAMLD1, a direct NR5A1 target previously associated with 46,XY DSD. In gonads of affected individuals, ovarian FOXL2 and testicular SRY-independent SOX9 expression observed. Conclusions: We propose NR5A1, previously associated with 46,XY DSD and 46,XX primary ovarian insufficiency, as a novel gene for 46,XX (ovo)testicular DSD. We hypothesize that p.(Arg92Trp) results in decreased inhibition of the male developmental pathway through downregulation of female antitestis genes, thereby tipping the balance toward testicular differentiation in 46,XX individuals. In conclusion, our study supports a role for NR5A1 in testis differentiation in the XX gonad. Genet Med 19 4, 367–376. PMID:27490115

  12. Remapping Genre: Spanish Jaiku of the Early Twentieth Century

    ERIC Educational Resources Information Center

    Landeira, Joy

    2010-01-01

    At the beginning of the twentieth century a new subgenre of poetry written in Spanish, but rooted in Japanese literary tradition, began to emerge in the works of Spain's vanguard and Generation of 1927 poets and among young modernist poets in Mexico and South America. Transmitted first through France and later directly from Japan, the popularity…

  13. A Method For The Longitudinal Study Of Behavioral Development In Infants And Children: The Early Development Of XXY Children

    ERIC Educational Resources Information Center

    Walzer, Stanley; And Others

    1978-01-01

    This report summarizes preliminary results from a behavioral study of 13 male infants who were ascertained to have an XX Y sex chromosome complement at birth and who are being followed longitudinally through early ontogenesis. (CM)

  14. A 46,XX Ovotesticular Disorder of Sex Development Likely Caused by a Steroidogenic Factor-1 (NR5A1) Variant.

    PubMed

    Swartz, Jonathan M; Ciarlo, Ryan; Guo, Michael H; Abrha, Aser; Weaver, Benjamin; Diamond, David A; Chan, Yee-Ming; Hirschhorn, Joel N

    2017-01-01

    A variant in steroidogenic factor-1 (SF-1, encoded by the gene NR5A1), p.Arg92Trp, has recently been reported in multiple families with 46,XX ovotesticular or testicular disorders of sex development (DSD). This amino acid change impacts the DNA-binding domain and perturbs gonadal differentiation pathways. Whole-exome sequencing was performed on a 46,XX subject with ovotesticular DSD. Exome results identified a heterozygous NR5A1 variant, p.Arg92Gln, in the 46,XX ovotesticular DSD proband. This arginine-to-glutamine change has been previously reported in the homozygous state in a 46,XY patient with gonadal and adrenal dysgenesis, though 46,XY and 46,XX heterozygous carriers of this variant have not been previously reported to have any clinical phenotype. The NR5A1 p.Arg92Gln variant, which has thus far only been seen in a family with 46,XY DSD, most likely contributes to the ovotesticular DSD in this case. In light of the recent reports of unrelated 46,XX subjects with testicular or ovotesticular DSD with the NR5A1 variant p.Arg92Trp, it appears that other mutations in the DNA binding domain have the potential to impact the factors determining testicular and ovarian differentiation. This case demonstrates the variability of phenotypes with the same genotype and broadens our understanding of the role of SF-1 in gonadal differentiation. © 2016 S. Karger AG, Basel.

  15. Familial ring (18) mosaicism in a 23-year-old young adult with 46,XY,r(18) (::p11→q21::)/46,XY karyotype, intellectual disability, motor retardation and single maxillary incisor and in his phenotypically normal mother, karyotype 47,XX,+r(18)(::p11→q21::)/46,XX.

    PubMed

    Balci, Sevim; Tümer, Celal; Karaca, Ciğdem; Bartsch, Oliver

    2011-05-01

    We report on a 23-year-old man with craniofacial findings of the holoprosencephaly spectrum disorder (microcephaly, hypotelorism, depressed nasal bridge, single median maxillary central incisor), fusion of C2-C3 vertebrae, intellectual disability, and severe sleep apnea. Chromosome analysis of blood lymphocytes showed 75% ring (18) cells and 25% normal cells, karyotype mos 46,XY,r(18)(::p11→q21::)[75]/46,XY[25]. His mother was phenotypically normal except for a double ureter and bifid renal pelvis as in his son. She had a supernumerary ring (18) in 10% of blood lymphocytes, karyotype mos 47,XX,+r(18)(::p11→q21::)[10]/46,XX[90]. Familial ring (18) is a rare cytogenetic abnormality. This is the first report of a mother with a supernumerary ring (18) and a son with ring (18) mosaicism. Interestingly, the son showed a true mosaicism (mixoploidy) of ring (18) and normal cells. The mother's 46,XX cells could be easily explained by mitotic instability and ring loss during cell division. However, the coexistence of ring (18) and normal cells in the son is unusual. Possibly, during early postzygotic divisions of a 47,XY,+r(18) zygote, two (possibly subsequent) genetic events could have occurred, one when one normal chromosome 18 was lost (resulting in a cell line with ring 18), and one when the ring 18 was lost (resulting in a cell line without ring, "escape to normal"). Alternatively, the zygote of the son could have been 46,XY,r(18), and postzygotic loss of the ring 18 could have resulted in monosomy 18 cells followed by duplication of chromosome 18 in these cells (a rare mechanism for cell survival previously described as "compensatory" isodisomy). Copyright © 2011 Wiley-Liss, Inc.

  16. Evidence of Active Dune Sand on the Great Plains in the 19th Century from Accounts of Early Explorers

    NASA Astrophysics Data System (ADS)

    Muhs, Daniel R.; Holliday, Vance T.

    1995-03-01

    Eolian sand is extensive over the Great Plains of North America, but is at present mostly stabilized by vegetation. Accounts published by early explorers, however, indicate that at least parts of dune fields in Nebraska, Colorado, Kansas, New Mexico, and Texas were active in the 19th century. Based on an index of dune mobility and a regional tree-ring record, the probable causes for these periods of greater eolian activity are droughts, accompanied by higher temperatures, which greatly lowered the precipitation-to-evapotranspiration ratio and diminished the cover of stabilizing vegetation. In addition, observations by several explorers, and previous historical studies, indicate that rivers upwind of Great Plains dune fields had shallow, braided, sandy channels, as well as intermittent flow in the 19th century. Wide, braided, sandy rivers that were frequently dry would have increased sand supplies to active dune fields. We conclude that dune fields in the Great Plains are extremely sensitive to climate change and that the potential for reactivation of stabilized dunes in the future is high, with or without greenhouse warming.

  17. An assemblage of science and home. The gendered lifestyle of Svante Arrhenius and early twentieth-century physical chemistry.

    PubMed

    Bergwik, Staffan

    2014-06-01

    This essay explores the gendered lifestyle of early twentieth-century physics and chemistry and shows how that way of life was produced through linking science and home. In 1905, the Swedish physical chemist Svante Arrhenius married Maja Johansson and established a scientific household at the Nobel Institute for Physical Chemistry in Stockholm. He created a productive context for research in which ideas about marriage and family were pivotal. He also socialized in similar scientific sites abroad. This essay displays how scholars in the international community circulated the gendered lifestyle through frequent travel and by reproducing gendered behavior. Everywhere, husbands and wives were expected to perform distinct duties. Shared performances created loyalties across national divides. The essay thus situates the physical sciences at the turn of the twentieth century in a bourgeois gender ideology. Moreover, it argues that the gendered lifestyle was not external to knowledge making but, rather, foundational to laboratory life. A legitimate and culturally intelligible lifestyle produced the trust and support needed for collaboration. In addition, it enabled access to prestigious facilities for Svante Arrhenius, ultimately securing his position in international physical chemistry.

  18. "Winged sponges": houseflies as carriers of typhoid fever in 19th- and early 20th-century military camps.

    PubMed

    Cirillo, Vincent J

    2006-01-01

    Typhoid fever was the scourge of 19th- and early 20th-century armies. During the Spanish-American War (1898) and the Anglo-Boer War (1899- 1902), typhoid killed more soldiers than enemy bullets. Walter Reed and his coworkers investigated the cause of the typhoid epidemics in the U.S. Army camps and concluded that, next to human contact, the housefly (Musca domestica) was the most active agent in the spread of the disease. British medical officers in South Africa, facing even worse typhoid epidemics, reached the same conclusion. The experiences of the American and British armies finally convinced the medical profession and public health authorities that these insects conveyed typhoid. The housefly was now seen as a health menace. Military and civilian sanitarians waged fly-eradication campaigns that prevented the housefly's access to breeding places (especially human excrement), and that protected food and drink from contamination. Currently, M. domestica is recognized as the mechanical vector of a wide variety of viral, bacterial, and protozoal pathogens. Fly control is still an important public health measure in the 21st century, especially in developing countries.

  19. Has psychology "found its true path"? Methods, objectivity, and cries of "crisis" in early twentieth-century French psychology.

    PubMed

    Carson, John

    2012-06-01

    This article explores how French psychologists understood the state of their field during the first quarter of the twentieth century, and whether they thought it was in crisis. The article begins with the Russian-born psychologist Nicolas Kostyleff and his announcement in 1911 that experimental psychology was facing a crisis. After briefly situating Kostyleff, the article examines his analysis of the troubles facing experimental psychology and his proposed solution, as well as the rather muted response his diagnosis received from the French psychological community. The optimism about the field evident in many of the accounts surveying French psychology during the early twentieth century notwithstanding, a few others did join Kostyleff in declaring that all was not well with experimental psychology. Together their pronouncements suggest that under the surface, important unresolved issues faced the French psychological community. Two are singled out: What was the proper methodology for psychology as a positive science? And what kinds of practices could claim to be objective, and in what sense? The article concludes by examining what these anxieties reveal about the type of science that French psychologists hoped to pursue. Copyright © 2011 Elsevier Ltd. All rights reserved.

  20. Brief communication: Unabated wastage of the Juneau and Stikine icefields (southeast Alaska) in the early 21st century

    NASA Astrophysics Data System (ADS)

    Berthier, Etienne; Larsen, Christopher; Durkin, William J.; Willis, Michael J.; Pritchard, Matthew E.

    2018-04-01

    The large Juneau and Stikine icefields (Alaska) lost mass rapidly in the second part of the 20th century. Laser altimetry, gravimetry and field measurements suggest continuing mass loss in the early 21st century. However, two recent studies based on time series of Shuttle Radar Topographic Mission (SRTM) and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) digital elevation models (DEMs) indicate a slowdown in mass loss after 2000. Here, the ASTER-based geodetic mass balances are recalculated carefully avoiding the use of the SRTM DEM because of the unknown penetration depth of the C-band radar signal. We find strongly negative mass balances from 2000 to 2016 (-0.68 ± 0.15 m w.e. a-1 for the Juneau Icefield and -0.83 ± 0.12 m w.e. a-1 for the Stikine Icefield), in agreement with laser altimetry, confirming that mass losses are continuing at unabated rates for both icefields. The SRTM DEM should be avoided or used very cautiously to estimate glacier volume change, especially in the North Hemisphere and over timescales of less than ˜ 20 years.

  1. Role Model Effects of Female STEM Teachers and Doctors on Early 20th Century University Enrollment in California. Research & Occasional Paper Series: CSHE.10.16

    ERIC Educational Resources Information Center

    Bleemer, Zach

    2016-01-01

    What was the role of imperfect local information in the growth, gender gap, and STEM (Science, Technology, Engineering and Math) major selection of early 20th century American universities? In order to examine pre-1950 American higher education, this study constructs four rich panel datasets covering most students, high school teachers, and…

  2. Genetic and physical analyses of Methylobacterium organophilum XX genes encoding methanol oxidation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Machlin, S.M.; Tam, P.E.; Bastien, C.A.

    When allyl alcohol was used as a suicide substrate, spontaneous mutants and UV light- and nitrous acid-generated mutants of Methylobacterium organophilum XX were selected which grew on methylamine but not on methanol. There was no detectable methanol dehydrogenase (MDH) activity in crude extracts of these mutants, yet Western blots revealed that some mutants still produced MDH protein. Complementation of 50 mutants by a cosmid gene bank of M. organophilum XX demonstrated that three major regions of the genome, each of which was separated by a minimum of 40 kilobases, were required for expression of active MDH. By subcloning and Tn5more » insertion mutagenesis of subcloned fragments, at least 11 genes clustered within these three regions were subsequently identified. The identity of the MDH structural gene, which was initially determined by hybridization to the structural gene of Methylobacterium sp. strain AM1, was confirmed by Western blot analysis of an MDH-..beta..-galactosidase fusion protein.« less

  3. Ancient mtDNA Analysis of Early 16th Century Caribbean Cattle Provides Insight into Founding Populations of New World Creole Cattle Breeds

    PubMed Central

    Speller, Camilla F.; Burley, David V.; Woodward, Robyn P.; Yang, Dongya Y.

    2013-01-01

    The Columbian Exchange resulted in a widespread movement of humans, plants and animals between the Old and New Worlds. The late 15th to early 16th century transfer of cattle from the Iberian Peninsula and Canary Islands to the Caribbean laid the foundation for the development of American creole cattle (Bos taurus) breeds. Genetic analyses of modern cattle from the Americas reveal a mixed ancestry of European, African and Indian origins. Recent debate in the genetic literature centers on the ‘African’ haplogroup T1 and its subhaplogroups, alternatively tying their origins to the initial Spanish herds, and/or from subsequent movements of taurine cattle through the African slave trade. We examine this problem through ancient DNA analysis of early 16th century cattle bone from Sevilla la Nueva, the first Spanish colony in Jamaica. In spite of poor DNA preservation, both T3 and T1 haplogroups were identified in the cattle remains, confirming the presence of T1 in the earliest Spanish herds. The absence, however, of “African-derived American” haplotypes (AA/T1c1a1) in the Sevilla la Nueva sample, leaves open the origins of this sub-haplogroup in contemporary Caribbean cattle. PMID:23894505

  4. Space power technology into the 21st century

    NASA Technical Reports Server (NTRS)

    Faymon, K. A.; Fordyce, J. S.

    1984-01-01

    This paper discusses the space power systems of the early 21st century. The focus is on those capabilities which are anticipated to evolve from today's state-of-the-art and the technology development programs presently in place or planned for the remainder of the century. The power system technologies considered include solar thermal, nuclear, radioisotope, photovoltaic, thermionic, thermoelectric, and dynamic conversion systems such as the Brayton and Stirling cycles. Energy storage technologies considered include nickel hydrogen biopolar batteries, advanced high energy rechargeable batteries, regenerative fuel cells, and advanced primary batteries. The present state-of-the-art of these space power and energy technologies is discussed along with their projections, trends and goals. A speculative future mission model is postulated which includes manned orbiting space stations, manned lunar bases, unmanned earth orbital and interplanetary spacecraft, manned interplanetary missions, military applications, and earth to space and space to space transportation systems. The various space power/energy system technologies anticipated to be operational by the early 21st century are matched to these missions.

  5. Space power technology into the 21st Century

    NASA Technical Reports Server (NTRS)

    Faymon, K. A.; Fordyce, J. S.

    1983-01-01

    The space power systems of the early 21st century are discussed. The capabilities which are anticipated to evolve from today's state of the art and the technology development programs presently in place or planned for the remainder of the century are emphasized. The power system technologies considered include: solar thermal, nuclear, radioisotope, photovoltaic, thermionic, thermoelectric, and dynamic conversion systems such as the Brayton and Stirling cycles. Energy storage technologies considered include: nickel hydrogen biopolar batteries, advanced high energy rechargeable batteries, regenerative fuel cells, and advanced primary batteries. The present state of the art of these space power and energy technologies is discussed along with their projections, trends and goals. A speculative future mission model is postulated which includes manned orbiting space stations, manned lunar bases, unmanned Earth orbital and interplanetary spacecraft, manned interplanetary missions, military applications, and Earth to space and space to space transportation systems. The various space power/energy system technologies which are anticipated to be operational by the early 21st century are matched to these missions.

  6. The Development of the Humanistic Curriculum in Fifteenth-Century Italy.

    ERIC Educational Resources Information Center

    Grendler, Paul F.

    One of the major changes in educational practices occurred during the Italian Renaissance, when a system of pre-university education based on a thorough grounding in the Latin, and to a lesser extent, the Greek classics began. This change started in early 15th century northern Italy and lasted until well into the 20th century. Italian school…

  7. Gallbladder Cancer in the 21st Century

    PubMed Central

    Kanthan, Rani; Senger, Jenna-Lynn; Ahmed, Shahid; Kanthan, Selliah Chandra

    2015-01-01

    Gallbladder cancer (GBC) is an uncommon disease in the majority of the world despite being the most common and aggressive malignancy of the biliary tree. Early diagnosis is essential for improved prognosis; however, indolent and nonspecific clinical presentations with a paucity of pathognomonic/predictive radiological features often preclude accurate identification of GBC at an early stage. As such, GBC remains a highly lethal disease, with only 10% of all patients presenting at a stage amenable to surgical resection. Among this select population, continued improvements in survival during the 21st century are attributable to aggressive radical surgery with improved surgical techniques. This paper reviews the current available literature of the 21st century on PubMed and Medline to provide a detailed summary of the epidemiology and risk factors, pathogenesis, clinical presentation, radiology, pathology, management, and prognosis of GBC. PMID:26421012

  8. Influence of high-latitude warming and land-use changes in the early 20th century northern Eurasian CO2 sink

    NASA Astrophysics Data System (ADS)

    Bastos, Ana; Peregon, Anna; Gani, Érico A.; Khudyaev, Sergey; Yue, Chao; Li, Wei; Gouveia, Célia M.; Ciais, Philippe

    2018-06-01

    While the global carbon budget (GCB) is relatively well constrained over the last decades of the 20th century [1], observations and reconstructions of atmospheric CO2 growth rate present large discrepancies during the earlier periods [2]. The large uncertainty in GCB has been attributed to the land biosphere, although it is not clear whether the gaps between observations and reconstructions are mainly because land-surface models (LSMs) underestimate inter-annual to decadal variability in natural ecosystems, or due to inaccuracies in land-use change reconstructions. As Eurasia encompasses about 15% of the terrestrial surface, 20% of the global soil organic carbon pool and constitutes a large CO2 sink, we evaluate the potential contribution of natural and human-driven processes to induce large anomalies in the biospheric CO2 fluxes in the early 20th century. We use an LSM specifically developed for high-latitudes, that correctly simulates Eurasian C-stocks and fluxes from observational records [3], in order to evaluate the sensitivity of the Eurasian sink to the strong high-latitude warming occurring between 1930 and 1950. We show that the LSM with improved high-latitude phenology, hydrology and soil processes, contrary to the group of LSMs in [2], is able to represent enhanced vegetation growth linked to boreal spring warming, consistent with tree-ring time-series [4]. By compiling a dataset of annual agricultural area in the Former Soviet Union that better reflects changes in cropland area linked with socio-economic fluctuations during the early 20th century, we show that land-abadonment during periods of crisis and war may result in reduced CO2 emissions from land-use change (44%–78% lower) detectable at decadal time-scales. Our study points to key processes that may need to be improved in LSMs and LUC datasets in order to better represent decadal variability in the land CO2 sink, and to better constrain the GCB during the pre-observational record.

  9. Audit-Proof Contracting for Federal Money for Children's Services: Financing Services for Children through Title XX and Other Programs. Manual 3.

    ERIC Educational Resources Information Center

    Copeland, William C.

    This is the third of a 3-part series on how to locate, obtain, and manage Federal money for children's services. This manual concentrates on the contracting of money for specific programs. Emphasis is on Title XX of the Social Security Act, but attention is given also to alternative sources where Title XX funds are not sufficient. Although useful…

  10. Alfred Owre: revisiting the thought of a distinguished, though controversial, early twentieth-century dental educator.

    PubMed

    Nash, David A

    2013-08-01

    Many in dental education are unfamiliar with the professional life and thought of Dr. Alfred Owre, a distinguished though controversial dental educator in the early twentieth century. Owre served as dean of dentistry at both the University of Minnesota, 1905-27, and Columbia University, 1927-33. He was also a member of the Carnegie Foundation's commission that developed the report Dental Education in the United States and Canada, written by Dr. William J. Gies. Owre was a controversial leader due to his creative and original ideas that challenged dental education and the profession. His assessment and critique of the problems of dental education in his era can readily be applied to contemporary dental education and the profession, just as his vision for transformative change resonates with ideas that continue to be advocated by some individuals today. This article also documents his tumultuous relationship with Gies.

  11. Wide spectrum of NR5A1-related phenotypes in 46,XY and 46,XX individuals.

    PubMed

    Domenice, Sorahia; Machado, Aline Zamboni; Ferreira, Frederico Moraes; Ferraz-de-Souza, Bruno; Lerario, Antonio Marcondes; Lin, Lin; Nishi, Mirian Yumie; Gomes, Nathalia Lisboa; da Silva, Thatiana Evelin; Silva, Rosana Barbosa; Correa, Rafaela Vieira; Montenegro, Luciana Ribeiro; Narciso, Amanda; Costa, Elaine Maria Frade; Achermann, John C; Mendonca, Berenice Bilharinho

    2016-12-01

    Steroidogenic factor 1 (NR5A1, SF-1, Ad4BP) is a transcriptional regulator of genes involved in adrenal and gonadal development and function. Mutations in NR5A1 have been among the most frequently identified genetic causes of gonadal development disorders and are associated with a wide phenotypic spectrum. In 46,XY individuals, NR5A1-related phenotypes may range from disorders of sex development (DSD) to oligo/azoospermia, and in 46,XX individuals, from 46,XX ovotesticular and testicular DSD to primary ovarian insufficiency (POI). The most common 46,XY phenotype is atypical or female external genitalia with clitoromegaly, palpable gonads, and absence of Müllerian derivatives. Notably, an undervirilized external genitalia is frequently seen at birth, while spontaneous virilization may occur later, at puberty. In 46,XX individuals, NR5A1 mutations are a rare genetic cause of POI, manifesting as primary or secondary amenorrhea, infertility, hypoestrogenism, and elevated gonadotropin levels. Mothers and sisters of 46,XY DSD patients carrying heterozygous NR5A1 mutations may develop POI, and therefore require appropriate counseling. Moreover, the recurrent heterozygous p.Arg92Trp NR5A1 mutation is associated with variable degrees of testis development in 46,XX patients. A clear genotype-phenotype correlation is not seen in patients bearing NR5A1 mutations, suggesting that genetic modifiers, such as pathogenic variants in other testis/ovarian-determining genes, may contribute to the phenotypic expression. Here, we review the published literature on NR5A1-related disease, and discuss our findings at a single tertiary center in Brazil, including ten novel NR5A1 mutations identified in 46,XY DSD patients. The ever-expanding phenotypic range associated with NR5A1 variants in XY and XX individuals confirms its pivotal role in reproductive biology, and should alert clinicians to the possibility of NR5A1 defects in a variety of phenotypes presenting with gonadal dysfunction

  12. Population pharmacokinetics and pharmacodynamics of ticagrelor and AR-C124910XX in Chinese healthy male subjects.

    PubMed

    Liu, Shuaibing; Xue, Ling; Shi, Xiangfen; Sun, Zhiyong; Zhu, Zhenfeng; Zhang, Xiaojian; Tian, Xin

    2018-06-01

    Ticagrelor, the first reversible P2Y 12 receptor antagonist, exhibits faster onset and offset of antiplatelet effects and more consistent platelet inhibition than clopidogrel in both healthy subjects and patients with stable coronary artery disease. The objectives of this study were to establish a population pharmacokinetics (PK) and pharmacodynamics (PD) model of ticagrelor and to provide a theoretical basis for the optimization of ticagrelor treatment in clinic. A single oral dose of 180 mg ticagrelor was administered to 14 healthy male subjects in a randomized study. Common single-nucleotide polymorphisms (SNPs) in biotransformation enzymes CYP3A4 and CYP3A5 (CYP3A4*1G and CYP3A5*3) were genotyped by PCR-direct sequencing. Blood samples were collected to measure plasma concentrations of ticagrelor and its active metabolite AR-C124910XX and maximal platelet inhibition. Various models were evaluated to characterize the pharmacokinetics of ticagrelor and AR-C124910XX as well as their PK-PD relationship. Covariates that may potentially affect PK or PD of ticagrelor and AR-C124910XX were included and assessed. Simulation for dosage regimen was performed based on the final PK-PD model. Ticagrelor and AR-C124910XX PK were best described by a two-compartment model with first-order transit absorption model. CYP3A4*1G increased clearance for AR-C124910XX, but had no significant effect on ticagrelor clearance. The relationship between concentration and platelet response of ticagrelor was best described by a turnover model. Simulation results indicated that a lower dosage regimen of 30 mg maintenance dose (MD) could produce an anticipated anti-platelet response in comparison to the routine clinical dosage regimen (180 mg loading dose (LD), 90 mg MD). Our study developed a population PK-PD model for ticagrelor and further simulation for dosage regimen was performed based on the final model. Compared to the current recommended dosage regimen (180 mg LD, 90 mg MD), our

  13. A History of Medicine and the Establishment of Medical Institutions in Middlesex County, New Jersey that Transformed Doctor and Patient Relationships during the Early Twentieth Century

    ERIC Educational Resources Information Center

    Whitfield-Spinner, Linda

    2011-01-01

    The early twentieth century was a period of tremendous advancements in medicine and technology and as a result experienced a revolutionary change in the delivery of healthcare in America. Modern medicine which encompassed specialized knowledge, technical procedures, and rules of behavior, changed the way medical care was provided in the United…

  14. XX ovarian dysgenesis is caused by a PSMC3IP/HOP2 mutation that abolishes coactivation of estrogen-driven transcription.

    PubMed

    Zangen, David; Kaufman, Yotam; Zeligson, Sharon; Perlberg, Shira; Fridman, Hila; Kanaan, Moein; Abdulhadi-Atwan, Maha; Abu Libdeh, Abdulsalam; Gussow, Ayal; Kisslov, Irit; Carmel, Liran; Renbaum, Paul; Levy-Lahad, Ephrat

    2011-10-07

    XX female gonadal dysgenesis (XX-GD) is a rare, genetically heterogeneous disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. Most cases are unexplained but thought to be autosomal recessive. We elucidated the genetic basis of XX-GD in a highly consanguineous Palestinian family by using homozygosity mapping and candidate-gene and whole-exome sequencing. Affected females were homozygous for a 3 bp deletion (NM_016556.2, c.600_602del) in the PSMC3IP gene, leading to deletion of a glutamic acid residue (p.Glu201del) in the highly conserved C-terminal acidic domain. Proteasome 26S subunit, ATPase, 3-Interacting Protein (PSMC3IP)/Tat Binding Protein Interacting Protein (TBPIP) is a nuclear, tissue-specific protein with multiple functions. It is critical for meiotic recombination as indicated by the known role of its yeast ortholog, Hop2. Through the C terminus (not present in yeast), PSMC3IP also coactivates ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. In cell lines, the p.Glu201del mutation abolished PSMC3IP activation of estrogen-driven transcription. Impaired estrogenic signaling can lead to ovarian dysgenesis both by affecting the size of the follicular pool created during fetal development and by failing to counteract follicular atresia during puberty. PSMC3IP joins previous genes known to be mutated in XX-GD, the FSH receptor, and BMP15, highlighting the importance of hormonal signaling in ovarian development and maintenance and suggesting a common pathway perturbed in isolated XX-GD. By analogy to other XX-GD genes, PSMC3IP is also a candidate gene for premature ovarian failure, and its role in folliculogenesis should be further investigated. Copyright © 2011 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  15. An XXX male resulting from paternal X-Y interchange and maternal X-X nondisjunction.

    PubMed Central

    Annerén, G; Andersson, M; Page, D C; Brown, L G; Berg, M; Läckgren, G; Gustavson, K H; de la Chapelle, A

    1987-01-01

    A 2-year-old boy was found to have a 47,XXX karyotype. Restriction-fragment-length-polymorphism analysis showed that, of his three X chromosomes, one is of paternal and two are of maternal origin. The results of Y-DNA hybridization were reminiscent of those in XX males in two respects. First, hybridization to Southern transfers revealed the presence in this XXX male of sequences derived from the Y-chromosomal short arm. Second, in situ hybridization showed that this Y DNA was located on the tip of the X-chromosomal short arm. We conclude that this XXX male resulted from the coincidence of X-X nondisjunction during maternal meiosis and aberrant X-Y interchange either during or prior to paternal meiosis. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 PMID:2889356

  16. Copy number variation in the region harboring SOX9 gene in dogs with testicular/ovotesticular disorder of sex development (78,XX; SRY-negative).

    PubMed

    Marcinkowska-Swojak, Malgorzata; Szczerbal, Izabela; Pausch, Hubert; Nowacka-Woszuk, Joanna; Flisikowski, Krzysztof; Dzimira, Stanislaw; Nizanski, Wojciech; Payan-Carreira, Rita; Fries, Ruedi; Kozlowski, Piotr; Switonski, Marek

    2015-10-01

    Although the disorder of sex development in dogs with female karyotype (XX DSD) is quite common, its molecular basis is still unclear. Among mutations underlying XX DSD in mammals are duplication of a long sequence upstream of the SOX9 gene (RevSex) and duplication of the SOX9 gene (also observed in dogs). We performed a comparative analysis of 16 XX DSD and 30 control female dogs, using FISH and MLPA approaches. Our study was focused on a region harboring SOX9 and a region orthologous to the human RevSex (CanRevSex), which was located by in silico analysis downstream of SOX9. Two highly polymorphic copy number variable regions (CNVRs): CNVR1 upstream of SOX9 and CNVR2 encompassing CanRevSex were identified. Although none of the detected copy number variants were specific to either affected or control animals, we observed that the average number of copies in CNVR1 was higher in XX DSD. No copy variation of SOX9 was observed. Our extensive studies have excluded duplication of SOX9 as the common cause of XX DSD in analyzed samples. However, it remains possible that the causative mutation is hidden in highly polymorphic CNVR1.

  17. Copy number variation in the region harboring SOX9 gene in dogs with testicular/ovotesticular disorder of sex development (78,XX; SRY-negative)

    PubMed Central

    Marcinkowska-Swojak, Malgorzata; Szczerbal, Izabela; Pausch, Hubert; Nowacka-Woszuk, Joanna; Flisikowski, Krzysztof; Dzimira, Stanislaw; Nizanski, Wojciech; Payan-Carreira, Rita; Fries, Ruedi; Kozlowski, Piotr; Switonski, Marek

    2015-01-01

    Although the disorder of sex development in dogs with female karyotype (XX DSD) is quite common, its molecular basis is still unclear. Among mutations underlying XX DSD in mammals are duplication of a long sequence upstream of the SOX9 gene (RevSex) and duplication of the SOX9 gene (also observed in dogs). We performed a comparative analysis of 16 XX DSD and 30 control female dogs, using FISH and MLPA approaches. Our study was focused on a region harboring SOX9 and a region orthologous to the human RevSex (CanRevSex), which was located by in silico analysis downstream of SOX9. Two highly polymorphic copy number variable regions (CNVRs): CNVR1 upstream of SOX9 and CNVR2 encompassing CanRevSex were identified. Although none of the detected copy number variants were specific to either affected or control animals, we observed that the average number of copies in CNVR1 was higher in XX DSD. No copy variation of SOX9 was observed. Our extensive studies have excluded duplication of SOX9 as the common cause of XX DSD in analyzed samples. However, it remains possible that the causative mutation is hidden in highly polymorphic CNVR1. PMID:26423656

  18. The Nineteenth-Century Revolution in Astronomy

    NASA Astrophysics Data System (ADS)

    Batten, Alan Henry

    2015-08-01

    The term "revolution" in scientific contexts usually refers either to the beginnings of modern western science in the sixteenth and seventeenth centuries, or to the two great revolutions of early twentieth century physics. Comparison of what was known at the beginning of the nineteenth century with what was known at the end, however, shows that century to have been one of transformation in astronomy, and in the other sciences, that amounts to "revolution". Astronomers in 1800 knew neither the nature of the Sun nor the distances of the stars. Developments in instrumentation enabled the first determinations of stellar parallax in the 1830s, and later enabled the solar prominences to be studied outside the brief momemnts of total eclipses. The development of photography and of spectroscopy led to the birth of observational astrophysics, while the greater understanding of the nature of heat and the rise of thermodynamics made possible the first attempts to investigate the theory of stellar structure. Nothing was known in 1800 of extra-galactic objects apart from some tentative identifcations by William Herschel but, by the end of the century, the discovery of the spiral structure of some nebulae had led some to believe that these were the "island universes" about which Kant had speculated. Of course, astrophysics and cosmology would be much further developed in the twentieth century and those of us whose careers spanned the second half of that century look back on it as a "golden age" for astronomy; but the nineteenth century was undoubtedly a time of rapid transformation and can be reasonably described as as one of the periods of revolution in astronomy.

  19. Clinical features and management of 33 patients with 46,XX pure gonadal dysgenesis.

    PubMed

    Huang, He; Wang, Chun-Qing; Tian, Qin-Jie

    2016-12-01

    The objective of the study is to summarize the clinical characteristics of 33 patients' cohort (46,XX pure gonadal dysgenesis, 46,XX PGD), discuss the management, and propose treatment suggestions. Patients' information, medical history, and medical records were obtained. All patients were closely followed up. At the time of diagnosis, the patients presented 19.53 ± 3.60 years old, 165 ± 6.49 cm height, breast development of Tanner stage I, and infantile female genitalia. High level of follicle-stimulating hormone (87.41 ± 21.50 mIU/mL) and LH (27.10 ± 8.47 mIU/mL) and low level of E2 (8.85 ± 6.13 pg/mL) were observed. Individualized hormone replacement therapy (HRT) was initiated after diagnosis. After 2 years of treatment, all patients had obvious breast development; the uterus showed (2.38 ± 0.60) × (1.38 ± 0.70) × (1.38 ± 0.55) cm growth. The incidence of osteopenia changed from 69.70% to 22.22% and that of osteoporosis changed from 18.18% to 0. Dysgeminoma was found in one patient. We concluded that gonadal dysgenesis in 46,XX PGD causes secondary sexual characteristic absence, tendency of taller, osteoporosis, infertility, and sexual health problems. There is minor chance of tumor occurrence for the patients. Optimal care including HRT and close follow-up are required.

  20. Planning ideology and geographic thought in the early twentieth century: Charles Whitnall's progressive era park designs for socialist Milwaukee.

    PubMed

    Platt, Lorne A

    2010-01-01

    As Milwaukee’s chief park planner in the early to mid-twentieth century, Charles Whitnall responded to the various underlying ideologies of the period within which he worked. His preference for parks was a political and physical response to and remedy for the industrialized and heavily congested city he called home. By examining the Progressive Era discourse associated with planning, this article situates Whitnall’s work within the political, aesthetic, and environmental contexts of geographic thought that influenced his plans for Milwaukee. In promoting a physical awareness associated with the natural features of the region and responding to the sociopolitical framework of contemporaries such as Ebenezer Howard, Whitnall incorporated a sense of compassion within his planning. He responded to the preexisting beer gardens of Pabst and Schlitz, as well as Olmsted-designed park spaces, by advocating for decentralization as part of a broader socialist agenda that had swept through Milwaukee during the early 1900s.

  1. A young male adolescent with feminine appearance: diagnosis of 46, XX syndrome neglected for 4 years with gynaecomastia presentation.

    PubMed

    Fu, C-P; Sheu, W H-H; Tseng, J-J; Lin, S-Y

    2014-04-01

    Gynaecomastia is common in infancy and adolescent boys, but other inciting causes should be kept in mind and necessitate further evaluation should be conducted to determine any underlying conditions. A 22-year-old unmarried male adolescent visited our endocrinology clinic for feminine appearance despite operations for bilateral gynaecomastia 4 years ago. Physical examination showed inverted triangular distribution of pubic hair, sparse beard, small-sized testes, flaccid short penis and surgical scar of the chest wall. Serum hormones study revealed primary hypergonadotropic hypogonadism, and cytogenetic study disclosed female complement (46, XX). The authors recommend that sexual chromosome abnormality should be considered in patients with hypogonadism to avert androgen deficiency-related complications early and that long-term team care should be provided to improve the patient's health-related quality of life. © 2013 Blackwell Verlag GmbH.

  2. 49 CFR 1242.73 - Cleaning car interiors and freight lost and damaged-all other (accounts XX-53-70 and 51-53-00).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Cleaning car interiors and freight lost and damaged-all other (accounts XX-53-70 and 51-53-00). 1242.73 Section 1242.73 Transportation Other... freight lost and damaged—all other (accounts XX-53-70 and 51-53-00). Separate common expenses on basis of...

  3. Clinical, cytogenetic, and molecular analysis with 46,XX male sex reversal syndrome: case reports.

    PubMed

    Gao, Xuefeng; Chen, Guian; Huang, Jing; Bai, Quan; Zhao, Nan; Shao, Minjie; Jiao, Liping; Wei, Yanling; Chang, Liang; Li, Dan; Yang, Liping

    2013-03-01

    To investigate the clinical characteristics of different categories of sex-reversed 46,XX individuals and their relationships with chromosomal karyotype and the SRY gene. Chromosome karyotyping for peripheral blood culture and multi-PCR and FISH were performed. Endocrinological data showed that their endocrine hormone levels were similar to that observed for Klinefelter syndrome, with higher FSH and LH levels and lower T levels. Chromosome karyotyping for peripheral blood culture revealed 46, XX complement for 11 males. Molecular studies showed that there were locus deletions at SY84, SY86, SY127, SY134, SY254 and SY255 in AZF on chromosome Y in 9 cases, with the SRY gene present at the terminus of the X chromosome short arm. In one case, besides 6 locus deletions in AZF, there was also SRY gene deletion. In another case, there were locus deletions only at SY254 and SY255, with SY84, SY86, SY127 SY134 loci and SRY present. The majority (10/11) of 46,XX males were SRY positive, with the SRY gene translocated into the terminus of the X chromosome short arm. These patients were caused mainly by an X/Y chromosomal inter-change during paternal meiosis, leading to the differentiation of primary gonads into testes. Only a single patient (1/11) was SRY-negative, in which there might be some unknown downstream genes involved in sex determination.

  4. Immigration and the American century.

    PubMed

    Hirschman, Charles

    2005-11-01

    The full impact of immigration on American society is obscured in policy and academic analyses that focus on the short-term problems of immigrant adjustment. With a longer-term perspective, which includes the socioeconomic roles of the children of immigrants, immigration appears as one of the defining characteristics of twentieth-century America. Major waves of immigration create population diversity with new languages and cultures, but over time, while immigrants and their descendants become more "American," the character of American society and culture is transformed. In the early decades of the twentieth century, immigrants and their children were the majority of the workforce in many of the largest industrial cities; in recent decades, the arrival of immigrants and their families has slowed the demographic and economic decline of some American cities. The presence of immigrants probably creates as many jobs for native-born workers as are lost through displacement. Immigrants and their children played an important role in twentieth-century American politics and were influential in the development of American popular culture during the middle decades of the twentieth century. Intermarriage between the descendants of immigrants and old-stock Americans fosters a national identity based on civic participation rather than ancestry.

  5. Unique double de novo structural rearrangements for chromosome 11 with 46,XX,del(11)(q13q23)/46,XX,inv dup(11)(q13q23) in an infant with minor congenital abnormalities and delayed development

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tharapel, A.T.; Zhao, J.; Smith, M.E.

    1994-09-01

    Reported here is a patient with two most unusual structural rearrangements, both involving chromosome 11. The first cell line showed an interstitial deletion of a chromosome 11 with a 46,XX,del(11)(q13q23) chromosome complement. In the second cell line, one of the chromosome 11s had a duplication for the exact region, (11)(q13q23), that was deleted in the first cell line. This duplication also appeared to be inverted with karyotype 46,XX,inv dup(11)(q13q23). Interestingly, chromosome analysis did not reveal a normal cell line and the two abnormal cell lines were present in a 1:1 ratio. Parental chromosome analyses showed normal karyotypes. The patient wasmore » referred for genetic evaluation because of developmental delay. Minor congenital anomalies presented on physical examination included: weight and height at or below the 5th percentile, microcephaly, downward slanting palpebral fissures, severe clinodactyly of one toe, bilateral short fifth fingers and a broad based gait. Results of the MRI and urine metabolic screen were normal. Two hypotheses are advanced to explain the origin of the abnormality. It is most likely that the abnormality arose as a postzygotic event at the very early zygotic division. During the first DNA synthesis after fertilization and before the zygotic division, DNA synthesis errors could result in two chromatids, one with a deletion and the other with a duplication. It is also possible that after the DNA synthesis prior to the first cell division, the chromatids of the same chromosome 11 for unknown reasons were involved in uneven double somatic crossing over events resulting in deleted and duplicated chromatids, respectively. The 1:1 cell ratio found in the patient and the apparent non-existence of a normal cell line further suggest that the origin of the abnormality was post-zygotic.« less

  6. Mirrored changes in Antarctic ozone and stratospheric temperature in the late 20th versus early 21st centuries

    NASA Astrophysics Data System (ADS)

    Solomon, Susan; Ivy, Diane; Gupta, Mukund; Bandoro, Justin; Santer, Benjamin; Fu, Qiang; Lin, Pu; Garcia, Rolando R.; Kinnison, Doug; Mills, Michael

    2017-08-01

    Observed and modeled patterns of lower stratospheric seasonal trends in Antarctic ozone and temperature in the late 20th (1979-2000) and the early 21st (2000-2014) centuries are compared. Patterns of pre-2000 observed Antarctic ozone decreases and stratospheric cooling as a function of month and pressure are followed by opposite-signed (i.e., "mirrored") patterns of ozone increases and warming post-2000. An interactive chemistry-climate model forced by changes in anthropogenic ozone depleting substances produces broadly similar mirrored features. Statistical analysis of unforced model simulations (from long-term model control simulations of a few centuries up to 1000 years) suggests that internal and solar natural variability alone is unable to account for the pattern of observed ozone trend mirroring, implying that forcing is the dominant driver of this behavior. Radiative calculations indicate that ozone increases have contributed to Antarctic warming of the lower stratosphere over 2000-2014, but dynamical changes that are likely due to internal variability over this relatively short period also appear to be important. Overall, the results support the recent finding that the healing of the Antarctic ozone hole is underway and that coupling between dynamics, chemistry, and radiation is important for a full understanding of the causes of observed stratospheric temperature and ozone changes.

  7. 49 CFR 1242.46 - Computers and data processing equipment (account XX-27-46).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... REPORTS SEPARATION OF COMMON OPERATING EXPENSES BETWEEN FREIGHT SERVICE AND PASSENGER SERVICE FOR RAILROADS 1 Operating Expenses-Equipment § 1242.46 Computers and data processing equipment (account XX-27-46... 49 Transportation 9 2012-10-01 2012-10-01 false Computers and data processing equipment (account...

  8. 49 CFR 1242.46 - Computers and data processing equipment (account XX-27-46).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... REPORTS SEPARATION OF COMMON OPERATING EXPENSES BETWEEN FREIGHT SERVICE AND PASSENGER SERVICE FOR RAILROADS 1 Operating Expenses-Equipment § 1242.46 Computers and data processing equipment (account XX-27-46... 49 Transportation 9 2013-10-01 2013-10-01 false Computers and data processing equipment (account...

  9. 49 CFR 1242.46 - Computers and data processing equipment (account XX-27-46).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... REPORTS SEPARATION OF COMMON OPERATING EXPENSES BETWEEN FREIGHT SERVICE AND PASSENGER SERVICE FOR RAILROADS 1 Operating Expenses-Equipment § 1242.46 Computers and data processing equipment (account XX-27-46... 49 Transportation 9 2011-10-01 2011-10-01 false Computers and data processing equipment (account...

  10. 49 CFR 1242.46 - Computers and data processing equipment (account XX-27-46).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... REPORTS SEPARATION OF COMMON OPERATING EXPENSES BETWEEN FREIGHT SERVICE AND PASSENGER SERVICE FOR RAILROADS 1 Operating Expenses-Equipment § 1242.46 Computers and data processing equipment (account XX-27-46... 49 Transportation 9 2014-10-01 2014-10-01 false Computers and data processing equipment (account...

  11. 49 CFR 1242.46 - Computers and data processing equipment (account XX-27-46).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... REPORTS SEPARATION OF COMMON OPERATING EXPENSES BETWEEN FREIGHT SERVICE AND PASSENGER SERVICE FOR RAILROADS 1 Operating Expenses-Equipment § 1242.46 Computers and data processing equipment (account XX-27-46... 49 Transportation 9 2010-10-01 2010-10-01 false Computers and data processing equipment (account...

  12. Clinical, molecular and cytogenetic analysis of 46, XX testicular disorder of sex development with SRY-positive.

    PubMed

    Wu, Qiu-Yue; Li, Na; Li, Wei-Wei; Li, Tian-Fu; Zhang, Cui; Cui, Ying-Xia; Xia, Xin-Yi; Zhai, Jin-Sheng

    2014-08-28

    To review the possible mechanisms proposed to explain the etiology of 46, XX sex reversal by investigating the clinical characteristics and their relationships with chromosomal karyotype and the SRY(sex-determining region Y)gene. Five untreated 46, XX patients with SRY-positive were referred for infertility. Clinical data were collected, and Karyotype analysis of G-banding in lymphocytes and Fluorescence in situ hybridization (FISH) were performed. Genomic DNA from peripheral blood of the patients using QIAamp DNA Blood Kits was extracted. The three discrete regions, AZFa, AZFb and AZFc, located on the long arm of the Y chromosome, were performed by multiplex PCRs(Polymerase Chain Reaction) amplification. The set of PCR primers for the diagnosis of microdeletion of the AZFa, AZFb and AZFc region included: sY84, sY86, sY127, sY134, sY254, sY255, SRY and ZFX/ZFY. Our five patients had a lower body height. Physical examination revealed that their testes were small in volume, soft in texture and normal penis. Semen analyses showed azoospermia. All patients had a higher follicle-stimulating hormone(FSH), Luteinizing Hormone(LH) level, lower free testosterone, testosterone level and normal Estradiol, Prolactin level. Karyotype analysis of all patients confirmed 46, XX karyotype, and FISH analysis showed that SRY gene were positive and translocated to Xp. Molecular analysis revealed that the SRY gene were present, and the AZFa, AZFb and AZFc region were absent. This study adds cases on the five new 46, XX male individuals with SRY-positive and further verifies the view that the presence of SRY gene and the absence of major regions in Y chromosome should lead to the expectance of a completely masculinised phenotype, abnormal hormone levels and infertility.

  13. Historiography for Educational Leadership in Mathematics: Content Analysis of a 1904 K-8 Mathematics Series and the Early 20th Century Context of Its Use

    ERIC Educational Resources Information Center

    Goodwin, Diana

    2012-01-01

    Math education is as important today as it was 100 years ago when the early 20th century was transforming from the old world into an era of factories, airplanes, atomic energy, and medical breakthroughs. Educational leaders of the era were wrestling with how long children should stay in school, meeting the diverse needs of an influx of immigrants,…

  14. The Distribution and Cellular Lineages of XX and XY Cells in Gonads Associated with Ovotesticular Disorder of Sexual Development.

    PubMed

    Nishina-Uchida, Noriko; Fukuzawa, Ryuji; Ishii, Tomohiro; Anaka, Matthew R; Hasegawa, Tomonobu; Hasegawa, Yukihiro

    2016-01-01

    Individuals with a 46,XX/46,XY karyotype are categorized as ovotesticular disorder of sexual development (ODSD) and have gonads with either an ovary on one side and a testis on the other side or a mixed ovotestis. To examine the distribution of 46,XX and 46,XY cells in gonads of 3 patients with ODSD, FISH for X and Y chromosomes and immunohistochemistry for SOX9 and FOXL2 were carried out. FISH analysis showed that XX signals were present in Sertoli cells in the seminiferous tubules, while cells containing Y signals were seen in epithelia of ovarian follicles. The immunolabeling of SOX9 and FOXL2 in the seminiferous tubules and ovarian follicles was mutually exclusive, irrespective of the presence of reversed sex chromosomes. We therefore suggest that the fate of individual gonadal epithelial cells is determined not only by the sex chromosomes but also by local environmental factors. © 2016 S. Karger AG, Basel.

  15. Wide spectrum of NR5A1‐related phenotypes in 46,XY and 46,XX individuals

    PubMed Central

    Domenice, Sorahia; Machado, Aline Zamboni; Ferreira, Frederico Moraes; Ferraz‐de‐Souza, Bruno; Lerario, Antonio Marcondes; Lin, Lin; Nishi, Mirian Yumie; Gomes, Nathalia Lisboa; da Silva, Thatiana Evelin; Silva, Rosana Barbosa; Correa, Rafaela Vieira; Montenegro, Luciana Ribeiro; Narciso, Amanda; Costa, Elaine Maria Frade; Achermann, John C

    2016-01-01

    Steroidogenic factor 1 (NR5A1, SF‐1, Ad4BP) is a transcriptional regulator of genes involved in adrenal and gonadal development and function. Mutations in NR5A1 have been among the most frequently identified genetic causes of gonadal development disorders and are associated with a wide phenotypic spectrum. In 46,XY individuals, NR5A1‐related phenotypes may range from disorders of sex development (DSD) to oligo/azoospermia, and in 46,XX individuals, from 46,XX ovotesticular and testicular DSD to primary ovarian insufficiency (POI). The most common 46,XY phenotype is atypical or female external genitalia with clitoromegaly, palpable gonads, and absence of Müllerian derivatives. Notably, an undervirilized external genitalia is frequently seen at birth, while spontaneous virilization may occur later, at puberty. In 46,XX individuals, NR5A1 mutations are a rare genetic cause of POI, manifesting as primary or secondary amenorrhea, infertility, hypoestrogenism, and elevated gonadotropin levels. Mothers and sisters of 46,XY DSD patients carrying heterozygous NR5A1 mutations may develop POI, and therefore require appropriate counseling. Moreover, the recurrent heterozygous p.Arg92Trp NR5A1 mutation is associated with variable degrees of testis development in 46,XX patients. A clear genotype‐phenotype correlation is not seen in patients bearing NR5A1 mutations, suggesting that genetic modifiers, such as pathogenic variants in other testis/ovarian‐determining genes, may contribute to the phenotypic expression. Here, we review the published literature on NR5A1‐related disease, and discuss our findings at a single tertiary center in Brazil, including ten novel NR5A1 mutations identified in 46,XY DSD patients. The ever‐expanding phenotypic range associated with NR5A1 variants in XY and XX individuals confirms its pivotal role in reproductive biology, and should alert clinicians to the possibility of NR5A1 defects in a variety of phenotypes presenting with gonadal

  16. XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis

    PubMed Central

    Du, Sienmi; Itoh, Noriko; Askarinam, Sahar; Hill, Haley; Arnold, Arthur P.; Voskuhl, Rhonda R.

    2014-01-01

    Women are more susceptible to multiple sclerosis (MS) and have more robust immune responses than men. However, men with MS tend to demonstrate a more progressive disease course than women, suggesting a disconnect between the severity of an immune attack and the CNS response to a given immune attack. We have previously shown in an MS model, experimental autoimmune encephalomyelitis, that autoantigen-sensitized XX lymph node cells, compared with XY, are more encephalitogenic. These studies demonstrated an effect of sex chromosomes in the induction of immune responses, but did not address a potential role of sex chromosomes in the CNS response to immune-mediated injury. Here, we examined this possibility using XX versus XY bone marrow chimeras reconstituted with a common immune system of one sex chromosomal type. We found that experimental autoimmune encephalomyelitis mice with an XY sex chromosome complement in the CNS, compared with XX, demonstrated greater clinical disease severity with more neuropathology in the spinal cord, cerebellum, and cerebral cortex. A candidate gene on the X chromosome, toll-like receptor 7, was then examined. Toll-like receptor 7 expression in cortical neurons was higher in mice with XY compared with mice with XX CNS, consistent with the known neurodegenerative role for toll-like receptor 7 in neurons. These results suggest that sex chromosome effects on neurodegeneration in the CNS run counter to effects on immune responses, and may bear relevance to the clinical enigma of greater MS susceptibility in women but faster disability progression in men. This is a demonstration of a direct effect of sex chromosome complement on neurodegeneration in a neurological disease. PMID:24550311

  17. XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis.

    PubMed

    Du, Sienmi; Itoh, Noriko; Askarinam, Sahar; Hill, Haley; Arnold, Arthur P; Voskuhl, Rhonda R

    2014-02-18

    Women are more susceptible to multiple sclerosis (MS) and have more robust immune responses than men. However, men with MS tend to demonstrate a more progressive disease course than women, suggesting a disconnect between the severity of an immune attack and the CNS response to a given immune attack. We have previously shown in an MS model, experimental autoimmune encephalomyelitis, that autoantigen-sensitized XX lymph node cells, compared with XY, are more encephalitogenic. These studies demonstrated an effect of sex chromosomes in the induction of immune responses, but did not address a potential role of sex chromosomes in the CNS response to immune-mediated injury. Here, we examined this possibility using XX versus XY bone marrow chimeras reconstituted with a common immune system of one sex chromosomal type. We found that experimental autoimmune encephalomyelitis mice with an XY sex chromosome complement in the CNS, compared with XX, demonstrated greater clinical disease severity with more neuropathology in the spinal cord, cerebellum, and cerebral cortex. A candidate gene on the X chromosome, toll-like receptor 7, was then examined. Toll-like receptor 7 expression in cortical neurons was higher in mice with XY compared with mice with XX CNS, consistent with the known neurodegenerative role for toll-like receptor 7 in neurons. These results suggest that sex chromosome effects on neurodegeneration in the CNS run counter to effects on immune responses, and may bear relevance to the clinical enigma of greater MS susceptibility in women but faster disability progression in men. This is a demonstration of a direct effect of sex chromosome complement on neurodegeneration in a neurological disease.

  18. The Sertoli Cell Only Syndrome and Glaucoma in a Sex - Determining Region Y (SRY) Positive XX Infertile Male.

    PubMed

    Jain, Manish; V, Veeramohan; Chaudhary, Isha; Halder, Ashutosh

    2013-07-01

    The XX male syndrome is a rare genetic disorder. The phenotype is variable; it ranges from a severe impairment of the external genitalia to a normal male phenotype with infertility. It generally results from an unequal crossing over between the short arms of the sex chromosomes (X and Y). We are reporting a case of a 38-year-old man who presented with infertility and the features of hypogonadism and glaucoma. The examinations revealed normal external male genitalia, soft small testes, gynaecomastia and glaucoma. The semen analysis showed azoospermia. The serum gonadotropins were high, with low Anti Mullerian Hormone (AMH) and Inhibin B levels. The chromosomal analysis demonstrated a 46, XX karyotype. Fluorescent In-Situ Hybridization (FISH) and Polymerase Chain Reaction (PCR) revealed the presence of a Sex-determining Region Y (SRY). Testicular Fine Needle Aspiration Cytology (FNAC) revealed the Sertoli Cell Only Syndrome (SCOS). The presence of only Sertoli Cells in the testes, with glaucoma in the XX male syndrome, to our knowledge, has not been reported in the literature.

  19. Unique sex chromosome systems in Ellobius: How do male XX chromosomes recombine and undergo pachytene chromatin inactivation?

    PubMed

    Matveevsky, Sergey; Bakloushinskaya, Irina; Kolomiets, Oxana

    2016-07-18

    Most mammalian species have heteromorphic sex chromosomes in males, except for a few enigmatic groups such as the mole voles Ellobius, which do not have the Y chromosome and Sry gene. The Ellobius (XX ♀♂) system of sex chromosomes has no analogues among other animals. The structure and meiotic behaviour of the two X chromosomes were investigated for males of the sibling species Ellobius talpinus and Ellobius tancrei. Their sex chromosomes, despite their identical G-structure, demonstrate short synaptic fragments and crossover-associated MLH1 foci in both telomeric regions only. The chromatin undergoes modifications in the meiotic sex chromosomes. SUMO-1 marks a small nucleolus-like body of the meiotic XX. ATR and ubiH2A are localized in the asynaptic area and the histone γH2AFX covers the entire XX bivalent. The distribution of some markers of chromatin inactivation differentiates sex chromosomes of mole voles from those of other mammals. Sex chromosomes of both studied species have identical recombination and meiotic inactivation patterns. In Ellobius, similar chromosome morphology masks the functional heteromorphism of the male sex chromosomes, which can be seen at meiosis.

  20. Unique sex chromosome systems in Ellobius: How do male XX chromosomes recombine and undergo pachytene chromatin inactivation?

    PubMed Central

    Matveevsky, Sergey; Bakloushinskaya, Irina; Kolomiets, Oxana

    2016-01-01

    Most mammalian species have heteromorphic sex chromosomes in males, except for a few enigmatic groups such as the mole voles Ellobius, which do not have the Y chromosome and Sry gene. The Ellobius (XX ♀♂) system of sex chromosomes has no analogues among other animals. The structure and meiotic behaviour of the two X chromosomes were investigated for males of the sibling species Ellobius talpinus and Ellobius tancrei. Their sex chromosomes, despite their identical G-structure, demonstrate short synaptic fragments and crossover-associated MLH1 foci in both telomeric regions only. The chromatin undergoes modifications in the meiotic sex chromosomes. SUMO-1 marks a small nucleolus-like body of the meiotic XX. ATR and ubiH2A are localized in the asynaptic area and the histone γH2AFX covers the entire XX bivalent. The distribution of some markers of chromatin inactivation differentiates sex chromosomes of mole voles from those of other mammals. Sex chromosomes of both studied species have identical recombination and meiotic inactivation patterns. In Ellobius, similar chromosome morphology masks the functional heteromorphism of the male sex chromosomes, which can be seen at meiosis. PMID:27425629

  1. A rare 47 XXY/46 XX mosaicism with clinical features of Klinefelter syndrome.

    PubMed

    Mohd Nor, Noor Shafina; Jalaludin, Muhammad Yazid

    2016-01-01

    47 XXY/46 XX mosaicism with characteristics suggesting Klinefelter syndrome is very rare and at present, only seven cases have been reported in the literature. We report an Indian boy diagnosed as variant of Klinefelter syndrome with 47 XXY/46 XX mosaicism at age 12 years. He was noted to have right cryptorchidism and chordae at birth, but did not have surgery for these until age 3 years. During surgery, the right gonad was atrophic and removed. Histology revealed atrophic ovarian tissue. Pelvic ultrasound showed no Mullerian structures. There was however no clinical follow up and he was raised as a boy. At 12 years old he was re-evaluated because of parental concern about his 'female' body habitus. He was slightly overweight, had eunuchoid body habitus with mild gynaecomastia. The right scrotal sac was empty and a 2mls testis was present in the left scrotum. Penile length was 5.2 cm and width 2.0 cm. There was absent pubic or axillary hair. Pronation and supination of his upper limbs were reduced and x-ray of both elbow joints revealed bilateral radioulnar synostosis. The baseline laboratory data were LH < 0.1 mIU/ml, FSH 1.4 mIU/ml, testosterone 0.6 nmol/L with raised estradiol, 96 pmol/L. HCG stimulation test showed poor Leydig cell response. The karyotype based on 76 cells was 47 XXY[9]/46 XX[67] with SRY positive. Laparoscopic examination revealed no Mullerian structures. Insisting on an adequate number of cells (at least 50) to be examined during karyotyping is important so as not to miss diagnosing mosaicism.

  2. Gendered Perceptions of Father Involvement in Early Twentieth Century America.

    ERIC Educational Resources Information Center

    LaRossa, Ralph; Reitzes, Donald C.

    1995-01-01

    Analyzes 256 letters written by middle-class fathers and mothers to nationally known educator Angelo Patri to illustrate the degree to which perceptions of father involvement in the 1920s-30s varied according to gender. Suggests the difference in father involvement during the 20th century is not as sharp as some suppose. (Author/JPS)

  3. New Early Cycladic Figurine At Nea Styra

    NASA Astrophysics Data System (ADS)

    Kosma, M.

    The existence of an Early Bronze Age coastal site in the district of Nea Styra has been known since the end of the 19th century when three marble figurines of early Cycladic type had been found in the area. During the 20th century survey investigations conducted by Greek and foreign archaeologists offered new evidence which demonstrated the significance of the site during the Early and Middle Helladic periods. A new figurine of early Cycladic type, which recently came to light at Nea Styra due to the control of building permits by the 11th Ephorate of Prehistoric and Classical Antiquities, reaffirms the identification of the area as one of the three most important sites on Euboea during the Early Helladic II period. This paper focuses on a newly discovered figurine and its typological character. The new find is compared to the figurines that had been found in the 19th century at Nea Styra. We hope that the scheduled excavations on the private land plot where the new figurine was found will offer new data leading to a better understanding of the character of the Early Helladic settlement in this part of southern Euboea.

  4. 78 FR 10003 - Proposed Collection; Comment Request for Notice 2009-XX (NOT-151370-08)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... comments concerning Notice 2009-XX, Credit for Carbon Dioxide Sequestration under Section 45Q. [email protected] . SUPPLEMENTARY INFORMATION: Title: Credit for Carbon Dioxide Sequestration under Section... carbon dioxide sequestration (CO 2 sequestration credit) under Sec. 45Q of the Internal Revenue Code...

  5. A Portrait of the PETE Major: Re-Touched for the Early Twenty-First Century

    ERIC Educational Resources Information Center

    McCullick, Bryan A.; Lux, Karen M.; Belcher, Donald G.; Davies, Nigel

    2012-01-01

    Background: The literature on those who choose to become PE teachers received healthy attention in the late twentieth century but has been largely ignored since. Querying those PETE majors in first decade of the new century enables PETE faculty to have updated and pertinent knowledge of their charges. Purpose: The purpose of this study was to…

  6. The context for great lakes silviculture in the 21st century

    Treesearch

    David D. Reed

    2004-01-01

    Great Lakes forests were subject to a severe pulse of disturbance from the mid-19th century through the early 20th century that resulted from extensive harvesting and subsequent fires following European settlement. Today?s forest, in many ways, is exhibiting changes in area and demography that reflect recovery from this pulse of disturbance, as well as response to...

  7. Techniques for nothingness: Debate over the comparability of hypnosis and Zen in early-twentieth-century Japan.

    PubMed

    Wu, Yu-Chuan

    2017-12-01

    This paper explores a debate that took place in Japan in the early twentieth century over the comparability of hypnosis and Zen. The debate was among the first exchanges between psychology and Buddhism in Japan, and it cast doubt on previous assumptions that a clear boundary existed between the two fields. In the debate, we find that contemporaries readily incorporated ideas from psychology and Buddhism to reconstruct the experiences and concepts of hypnosis and Buddhist nothingness. The resulting new theories and techniques of nothingness were fruits of a fairly fluid boundary between the two fields. The debate, moreover, reveals that psychology tried to address the challenges and possibilities posed by religious introspective meditation and intuitive experiences in a positive way. In the end, however, psychology no longer regarded them as viable experimental or psychotherapeutic tools but merely as particular subjective experiences to be investigated and explained.

  8. In the laboratory of the Ghost-Baron: parapsychology in Germany in the early 20th century.

    PubMed

    Wolffram, Heather

    2009-12-01

    During the early twentieth century the Munich-based psychiatrist Albert von Schrenck-Notzing constructed a parapsychological laboratory in his Karolinenplatz home. Furnished with a range of apparatus derived from the physical and behavioural sciences, the Baron's intention was to mimic both the outward form and disciplinary trajectory of contemporary experimental psychology, thereby legitimating the nascent field of parapsychology. Experimentation with mediums, those labile subjects who produced ectoplasm, materialisation and telekinesis, however, necessitated not only the inclusion of a range of spiritualist props, but the lackadaisical application of those checks and controls intended to prevent simulation and fraud. Thus Schrenck-Notzing's parapsychological laboratory with its stereoscopic cameras, galvanometers and medium cabinets was a strange coalescence of both the séance room and the lab, a hybrid space that was symbolic of the irresolvable epistemological and methodological problems at the heart of this aspiring science.

  9. Modeling and Reality in Early Twentieth-Century Physics

    NASA Astrophysics Data System (ADS)

    Seth, Suman

    2011-04-01

    Towards the end of 1913, Arnold Sommerfeld, Professor of theoretical physics at Munich University, sent a letter of congratulations to a young Niels Bohr. The Dane's now-classic trilogy of papers, which coupled Rutherford's conception of the atom with a ``planetary'' configuration of electrons, had just appeared. Sommerfeld saw the calculation of the Rydberg constant as a singular triumph and immediately spotted an opportunity to try to explain the Zeeman effect. Yet he also sounded a note of caution, confessing that he remained ``somewhat skeptical'' of atomic models in general. In this, of course, he was hardly alone. Bohr's atom was a particularly egregious example of a peculiar model, one requiring what even its creator considered ``horrid assumptions.'' Nonetheless, success bred conviction. Expanding upon Bohr's original ideas, Sommerfeld soon produced the so-called ``Bohr-Sommerfeld quantization conditions,'' using them to calculate a myriad of results. Experimental evidence, Sommerfeld argued in 1915, showed that quantised electron-paths ``correspond exactly to reality'' and possess ``real existence.'' This kind of realism would not, of course, last long. In 1925, Werner Heisenberg (earlier a student of Sommerfeld's) made scepticism about the details of the Bohr model into a methodological dictum, one later enshrined in the ``Copenhagen interpretation'' of quantum mechanics. This paper uses Sommerfeld's work from the turn of the twentieth century to the mid-1920s as a window onto a landscape involving multiple contestations over the legitimacy of atomic modelling. The surprise that greeted Heisenberg's and others' phenomenological insistences, we will see, can only be understood with reference to what should be considered a ``realist interlude'' in the history of twentieth century atomic physics, one inspired by the astonishing successes of Rutherford's and Bohr's imaginings.

  10. TRIENNIAL LACTATION SYMPOSIUM/BOLFA:Historical perspectives of lactation biology in the late 20th and early 21st centuries.

    PubMed

    Collier, R J; Bauman, D E

    2017-12-01

    The latter half of the 20th century and the early portion of the 21st century will be recognized as the "Golden Age" of lactation biology. This period corresponded with the rise of systemic, metabolomic, molecular, and genomic biology. It includes the discovery of the structure of DNA and ends with the sequencing of the complete genomes of humans and all major domestic animal species including the dairy cow. This included the ability to identify polymorphisms in the nucleic acid sequence, which can be tied to specific differences in cellular, tissue, and animal performance. Before this period, classical work using endocrine ablation and replacement studies identified the mammary gland as an endocrine-dependent organ. In the early 1960s, the development of RIA and radioreceptor assays permitted the study of the relationship between endocrine patterns and mammary function. The ability to measure nucleic acid content of tissues opened the door to study of the factors regulating mammary growth. The development of high-speed centrifugation in the 1960s allowed separation of specific cell organelles and their membranes. The development of transmission and scanning electron microscopy permitted the study of the relationship between structure and function in the mammary secretory cell. The availability of radiolabeled metabolites provided the opportunity to investigate the metabolic pathways and their regulation. The development of concepts regarding the coordination of metabolism to support lactation integrated our understanding of nutrient partitioning and homeostasis. The ability to produce recombinant molecules and organisms permitted enhancement of lactation in farm animal species and the production of milk containing proteins of value to human medicine. These discoveries and others contributed to vastly increased dairy farm productivity in the United States and worldwide. This review will include the discussion of the centers of excellence and scientists who labored

  11. Atomic calculations for the Fe XX X-ray lines

    NASA Technical Reports Server (NTRS)

    Mason, H. E.; Bhatia, A. K.

    1983-01-01

    The atomic data presented here and in Bhatia and Mason (1980) allow the calculation of theoretical intensity ratios for all the EUV, UV, and X-ray lines from Fe XX. Tabulations are presently given for the transitions between levels in the 2s2 2p3, 2s2 2p2 3s, and 2s2 2p2 3d configurations of Fe(19+), and electron collision strengths are calculated by means of the 'distorted wave' approximation. In addition to the theoretical X-ray line intensity ratios, new spectral line identifications from a solar flare are presented.

  12. Composition of Façon de Venise glass from early 17th century London in comparison with luxury glass of the same age

    NASA Astrophysics Data System (ADS)

    Cagno, S.; De Raedt, I.; Jeffries, T.; Janssens, K.

    SEM-EDX and LA-ICP-MS analyses were performed on a set of early 17th century London glass fragments. The samples originate from two archaeological sites (Aldgate and Old Broad Street) where glass workshops were active in this period. The great majority of the samples are made of soda glass. Two distinct compositional groups are observed, each typical of one site of provenance. The samples originating from the Old Broad Street excavation feature a silica-soda-lime composition, with a moderate amount of potash. The samples from Aldgate are richer in potassium and feature higher amounts of trace elements such as Rb, Zr and Cu. The distinction between the two groups stems from different flux and silica sources used for glassmaking. A comparison with different European glass compositions of that time reveals no resemblance with genuine Venetian production, yet the composition of the Old Broad Street glass shows a close similarity to that of fragments produced `à la façon de Venise' in Antwerp at the end of the 16th century. This coincides with historical sources attesting the arrival of glassworkers from the Low Countries in England and suggests that a transfer of technology took place near the turn of the century.

  13. Nineteenth Century English Homosexual Teachers: The Up Front and Back Stage Performance.

    ERIC Educational Resources Information Center

    Bullough, Vern; Bullough, Bonnie

    Although homosexuality was considered to be a crime in nineteenth-century England, the subculture of the school system promoted it. For example, in the early nineteenth century schoolboys of all ages were locked up in dormitories at 8:00 p.m. and no master entered the building until the next morning. No-one supervised the boys' activities during…

  14. 14th-16th century Danube floods and long-term water-level changes reflected in archaeological-sedimentary evidence - in comparison with documentary evidence

    NASA Astrophysics Data System (ADS)

    Kiss, Andrea; Laszlovszky, József

    2014-05-01

    In the present paper an overview of published and unpublished results of archaeological and sedimentary investigations, predominantly reflect on 14th-16th-century changes, are provided and compared to documentary information on flood events and long-term changes. Long-term changes in flood behaviour and average water-level conditions had long-term detectable impacts on sedimentation and fluvio-morphological processes. Moreover, the available archaeological evidence might also provide information on the reaction of the society, in the form of changes in settlement organisation, building structures and processes. At present, information is mainly available concerning the 16th, and partly to the 14th-15th centuries. Medium and short term evidence mainly corresponds to the main flood peaks or even to single catastrophic flood events. Such processes may be identified in archaeological evidence concerning the second half of the 14th, early 15th centuries; while most of the cases listed above were connected to the flood peak (and/or generally increasing water-level conditions) of the late 15th and early 16th centuries. In other cases connections between sedimentary/archaeological evidence and the mid- and late 16th-century high flood-frequency period were presumed. Documentary evidence referring to the same period suggests that higher flood frequency and intensity periods occurred in the early and mid 16th century; a probably more prolonged flood rich period took place in the second half of the 16th century, with a peak in the late 1560s-early 1570s and maybe with another at the end of the 16th century. Earlier flood peaks in documentary evidence were detected on the Danube at the turn of the 14th-15th centuries and in the last decades of the 15th century, continuing in the early 16th century.

  15. Case of 46,XX/47,XY, +21 chimerism in a newborn infant with ambiguous genitalia

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sawai, Tomoko; Yoshimoto, Masaaki; Kinoshita, Ei-ichi

    The authors describe the whole-body chimerism in a newborn infant with small phallus, pseudo-vaginal perineal hypospadias, and a bifid scrotum containing gonads. The human testis determining factor gene (SRY) was detected by PCR amplification. GTG-banding chromosome analysis in peripheral blood lymphocytes and cultured fibroblasts derived from right cubital skin showed a 46,XX/47,XY, +21 karyotype. Their ratios in each cell line were 294:5 and 178:7, respectively. QFQ-banding chromosome analysis documented 3 heteromorphic satellites on trisomic chromsomes 21 in the 47,XY,+21 cell line and a homozygous satellite pattern in the 46,XX cell line. Heteromorphic patterns of chromsomes 4, 13, 14, and 22more » were also different between the two cell lines. To our knowledge, such disomy/trisomy chimeras have not been described previously. 10 refs., 3 figs.« less

  16. Obtaining highly excited eigenstates of the localized XX chain via DMRG-X

    NASA Astrophysics Data System (ADS)

    Devakul, Trithep; Khemani, Vedika; Pollmann, Frank; Huse, David A.; Sondhi, S. L.

    2017-10-01

    We benchmark a variant of the recently introduced density matrix renormalization group (DMRG)-X algorithm against exact results for the localized random field XX chain. We find that the eigenstates obtained via DMRG-X exhibit a highly accurate l-bit description for system sizes much bigger than the direct, many-body, exact diagonalization in the spin variables is able to access. We take advantage of the underlying free fermion description of the XX model to accurately test the strengths and limitations of this algorithm for large system sizes. We discuss the theoretical constraints on the performance of the algorithm from the entanglement properties of the eigenstates, and its actual performance at different values of disorder. A small but significant improvement to the algorithm is also presented, which helps significantly with convergence. We find that, at high entanglement, DMRG-X shows a bias towards eigenstates with low entanglement, but can be improved with increased bond dimension. This result suggests that one must be careful when applying the algorithm for interacting many-body localized spin models near a transition. This article is part of the themed issue 'Breakdown of ergodicity in quantum systems: from solids to synthetic matter'.

  17. Detection of the testis determining factor in an XX man.

    PubMed

    Fukutani, K; Kajiwara, T; Nagafuchi, S; Nakahori, Y; Nakagome, Y

    1993-01-01

    An XX male patient was examined for the presence of 25 loci on the Y chromosome. Only 2 loci, the proximal border of the pseudoautosomal region Y and the sex determining region Y, were detected in this patient. The other 23 loci, including the zinc finger protein Y, were absent. We presume that a crossing over between the X and Y chromosomes occurred at the region proximal to the sex determining region Y but distal to the zinc finger protein Y during meiosis of the father.

  18. Experimental Analyses of Yellow Tuff Spandrels of Post-medieval Buildings in the Naples Area

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Calderoni, B.; Cordasco, E. A.; Lenza, P.

    2008-07-08

    Experimental analyses have been carried out on tuff masonry specimens in order to investigate the structural behaviour of historical buildings in the Naples area (Southern Italy). Spandrels of post-medieval buildings (late XVI to early XX century) have been analysed, with emphasis on morphological characteristics according to chronological indicators. Results of the experimentation on scaled models (1:10) are discussed and the better behaviour of historical masonry typologies on respect to the modern one is highlighted. Comparison with theoretical formulations of ultimate shear resistance are provided too.

  19. [20th century medical debate over venereal disease and prostitution].

    PubMed

    Lundberg, A

    2001-01-01

    In the early twentieth century a wider debate took place about how Swedish society was to fight the spread of contagious venereal diseases and in 1910 a government committee had written a law proposal that would dramatically reform these measures previously, Swedish physicians had been united against any measures against these diseases that did not involve the regulation of prostitutes, but this consensus was slowly withering away in the early parts of the century. Female doctors and a younger generation of venereologists was drawing the conclusion that mandatory checks of only one out of two sexes was insufficient. This article reviews the debate regarding the regulation of prostitution that took place between conservative and liberal members in the Swedish Medical Association in 1911. It depicts a fierce discussion between members that still clung to nineteenth-century ideas of women as being prone to prostitution if left idle and unemployed, and liberal members that believed social injustices such as low wages laid behind women's decisions. The study gives an insight into the complexities of building the Swedish welfare state.

  20. Warm Arctic-cold Siberia: comparing the recent and the early 20th-century Arctic warmings

    NASA Astrophysics Data System (ADS)

    Wegmann, Martin; Orsolini, Yvan; Zolina, Olga

    2018-02-01

    The Warm Arctic-cold Siberia surface temperature pattern during recent boreal winter is suggested to be triggered by the ongoing decrease of Arctic autumn sea ice concentration and has been observed together with an increase in mid-latitude extreme events and a meridionalization of tropospheric circulation. However, the exact mechanism behind this dipole temperature pattern is still under debate, since model experiments with reduced sea ice show conflicting results. We use the early twentieth-century Arctic warming (ETCAW) as a case study to investigate the link between September sea ice in the Barents-Kara Sea (BKS) and the Siberian temperature evolution. Analyzing a variety of long-term climate reanalyses, we find that the overall winter temperature and heat flux trend occurs with the reduction of September BKS sea ice. Tropospheric conditions show a strengthened atmospheric blocking over the BKS, strengthening the advection of cold air from the Arctic to central Siberia on its eastern flank, together with a reduction of warm air advection by the westerlies. This setup is valid for both the ETCAW and the current Arctic warming period.

  1. New early instrumental series since the beginning of the 19th century in eastern Iberia (Valencia, Spain)

    NASA Astrophysics Data System (ADS)

    Sanchez-Lorenzo, Arturo; Barriendos, Mariano; Guinaldo, Elena; Lopez-Bustins, Joan A.

    2010-05-01

    Early instrumental series are the main source for climate information in the 18th and the first part of the 19th century, which is when systematic meteorological observations started in most national meteorological services. The first continuous series in Spain starts in 1780 in Barcelona due to meteorological observations made by the medical doctor Francisco Salvá Campillo. Moreover, only two other series have been recovered at the present in Spain: Madrid and Cádiz/San Fernando. Until present, in Spain the major part of the meteorological observations detected in early instrumental periods were made by medical doctors, who started to pay attention to the environmental factors influencing population health under the Hippocrates oath, although also there are military institutions and academic university staff (e.g. physicists, mathematicians, etc.). Due to the high spatial and temporal climate variability in the Iberian Peninsula, it is important to recover and digitize more climatic series, and this is one of the main goals of the Salvá-Sinobas project (http://salva-sinobas.uvigo.es/) funded by the Spanish Ministry of Environment, and Rural and Marine Affairs for the 2009-2011 period. The first new series with systematic observations was detected in the city of Valencia, in the eastern façade of the Iberian Peninsula. The meteorological observations were daily published in the newspapers Diario de Valencia (1804-1834) and Diario Mercantil de Valencia (1837-1863) until official meteorological observations started in 1858 at the University of Valencia. Each day 3-daily observations (morning, midday, afternoon) were published with five climatic variables: temperature, air pressure, humidity, wind direction and the sky state. Only during the 1804-1808 period daily rainfall data is available. We checked the observer comments published in the newspapers to obtain metadata about the instruments and meteorological station information. Unfortunately, temperature data

  2. Metallographic examination of the structure of the metal of cold arms of the nineteenth-early twentieth centuries made at the Zlatoust arms factory

    NASA Astrophysics Data System (ADS)

    Schastlivtsev, V. M.; Rodionov, D. P.; Gerasimov, V. Yu.; Khlebnikova, Yu. V.

    2010-11-01

    Data are given concerning the structure and the chemical composition of carbon steel used for making cold arms, which was produced at the Zlatoust arms factory in the nineteenth and early twentieth centuries. The results of the analysis of the structure of metal demonstrates the general trend of the development of metallurgy both at the Ural plants and in the world: from the creation of the crucible methods of production of cast steel to the mass production of cast steel by the Bessemer and Martin methods.

  3. Demographic Data for Special Needs Children in Title XX Day Care. Report No. 7698.

    ERIC Educational Resources Information Center

    Asano, Mildred

    Presented are demographic data for handicapped children in the Philadelphia area who might be eligible for federally funded (Title XX) day care services. The report consists of data tables and narrative sections for the following information: estimated number of handicapped children within catchment areas (CA's); estimated median income level of…

  4. The adolescence of a thirteenth-century visionary nun.

    PubMed

    Kroll, J; De Ganck, R

    1986-11-01

    Among the most notable features of the religious revival in western Europe in the early thirteenth century was the development of mysticism among the nuns and religious women of the lowlands. As scholarly attention becomes increasingly focused on this group of remarkable women, the question arises whether a psychiatric viewpoint has something of value to offer to the understanding of such individuals and the culture in which they struggled. The methodological and intellectual problems inherent in examining the life of a thirteenth-century mystic with a twentieth-century empirical frame of reference are illustrated in this study of the adolescence of Beatrice of Nazareth. Beatrice's stormy asceticism, ecstatic states and mood swings lend themselves to potentially competing hypotheses regarding the spiritual and psychopathological significance of her adolescent development and eventual life-course. Common grounds for reconciling these alternative models are discussed.

  5. Early Rockets

    NASA Image and Video Library

    2004-04-15

    In the 19th Century, experiments in America, Europe, and elsewhere attempted to build postal rockets to deliver mail from one location to another. The idea was more novel than successful. Many stamps used in these early postal rockets have become collector's items.

  6. Case of successful IVF treatment of an oligospermic male with 46,XX/46,XY chimerism.

    PubMed

    Laursen, R J; Alsbjerg, B; Vogel, I; Gravholt, C H; Elbaek, H; Lildballe, D L; Humaidan, P; Vestergaard, E M

    2018-04-30

    We present a case of an infertile male with 46,XX/46,XYchimerism fathering a child after ICSI procedure. Conventional cytogenetic analysis on chromosomes, derived from lymphocytes, using standard Q-banding procedures with a 450-550-band resolution and short-tandem-repeat analysis of 14 loci. Analysis of 20 metaphases from lymphocytes indicated that the proband was a karyotypic mosaic with an almost equal distribution between male and female cell lines. In total, 12 of 20 (60%) metaphases exhibited a normal female karyotype 46,XX, while 8 of 20 (40%) metaphases demonstrated a normal male karyotype 46,XY. No structural chromosomal abnormalities were present. Out of 14 STR loci, two loci (D18S51 and D21S11) showed four different alleles in peripheral blood, buccal mucosal cells, conjunctival mucosal cells, and seminal fluid. In three loci (D2S1338, D7S820, and vWA), three alleles were detected with quantitative differences that indicated presence of four alleles. In DNA extracted from washed semen, four alleles were detected in one locus, and three alleles were detected in three loci. This pattern is consistent with tetragametic chimerism. There were no quantitative significant differences in peak heights between maternal and paternal alleles. STR-analysis on DNA from the son confirmed paternity. We report a unique case with 46,XX/46,XY chimerism confirmed to be tetragametic, demonstrated in several tissues, with male phenotype and no genital ambiguity with oligospermia fathering a healthy child after IVF with ICSI procedure.

  7. On the Causes and Dynamics of the Early Twentieth Century North American Pluvial

    NASA Technical Reports Server (NTRS)

    Cook, Benjamin I.; Seager, Richard; Miller, Ron L.

    2011-01-01

    The early twentieth century North American pluvial (1905-1917) was one of the most extreme wet periods of the last five hundred years and directly led to overly generous water allotments in the water-limited American West. Here we examine the causes and dynamics of the pluvial event using a combination of observation-based data sets and general circulation model (GCM) experiments. The character of the moisture surpluses during the pluvial differed by region, alternately driven by increased precipitation (the Southwest), low evaporation from cool temperatures (the Central Plains), or a combination of the two (the Pacific Northwest). Cool temperature anomalies covered much of the west and persisted through most months, part of a globally extensive period of cooler land and sea surface temperatures (SST). Circulation during boreal winter favored increased moisture import and precipitation in the southwest, while other regions and seasons were characterized by near normal or reduced precipitation. Anomalies in the mean circulation, precipitation, and SST fields are partially consistent with the relatively weak El Nino forcing during the pluvial, and also reflect the impact of positive departures in the Arctic Oscillation that occurred in ten of the thirteen pluvial winters. Differences between the reanalysis dataset, an independent statistical drought model, and GCM simulations highlight some of the remaining uncertainties in understanding the full extent of SST forcing of North American hydroclimatic variability.

  8. The early modern kidney--nephrology in and about the nineteenth century. Part 1.

    PubMed

    Eknoyan, Garabed

    2013-01-01

    The 19th century was a period of momentous scientific discoveries, technological achievements, and societal changes. A beneficiary of these revolutionary upheavals was medical empiricism that supplanted the rationalism of the past giving rise to early modern scientific medicine. Continued reliance on sensory data now magnified by technical advances generated new medical information that could be quantified with increasing precision, verified by repeated experimentation, and validated by statistical analysis. The institutionalization and integration of these methodologies into medical education were a defining step that assured their progress and perpetuation. Major advances were made in the nosography of diseases of the kidney, notably that of the diagnosis of progressive kidney disease from the presence of albuminuria by Richard Bright (1789-1858); and of renal structure and function, notably the demonstration of the continuity of the glomerular capsule with the tubular basement membrane by William Bowman (1816-1892), and the arguments for hemodynamic physical forces mediated glomerular filtration by Carl Ludwig (1816-1895) and for active tubular transport by Rudolf Heidenhain (1834-1897). Improvements in microscopy and tissue processing were instrumental in describing the cellular ultrastructure of the glomerulus and tubular segments, but their integrated function remained to be elucidated. The kidney continued to be considered a tubular secretory organ and its pathology attributed to injury of the interstitium (interstitial nephritis) or tubules (parenchymatous nephritis). © 2012 Wiley Periodicals, Inc.

  9. Tree ring-based seven-century drought records for the Western Himalaya, India

    NASA Astrophysics Data System (ADS)

    Yadav, Ram R.

    2013-05-01

    The paucity of available instrumental climate records in cold and arid regions of the western Himalaya, India, hampers our understanding of the long-term variability of regional droughts, which seriously affect the agrarian economy of the region. Using ring width chronologies of Cedrus deodara and Pinus gerardiana together from a network of moisture-stressed sites, Palmer Drought Severity Index values for October-May back to 1310 A.D. were developed. The twentieth century features dominant decadal-scale pluvial phases (1981-1995, 1952-1968, and 1918-1934) as compared to the severe droughts in the early seventeenth century (1617-1640) as well as late fifteenth to early sixteenth (1491-1526) centuries. The drought anomalies are positively (negatively) associated with central Pacific (Indo-Pacific Warm Pool) sea surface temperature anomalies. However, non-stationarity in such relationships appears to be the major riddle in the predictability of long-term droughts much needed for the sustainable development of the ecologically sensitive region of the Himalayas.

  10. Identification of ectopic ovotestis in a dog with XX ovotesticular, SRY-negative, disorder of sexual development.

    PubMed

    Diel de Amorim, M; Lerer, A; Durzi, T; Foster, R A; Gartley, C J

    2018-06-01

    A 1-year-old, previously spayed phenotypic female Poodle/Soft-coated Wheaten Terrier (Whoodle) cross was presented for a suspected ovarian remnant. Serum luteinizing hormone (LH) concentration was below the detection limit (<1 ng/ml Witness ® LH), and serum progesterone concentration was elevated in the chemiluminescence immunoassay (CLIA; 20 ng/ml), consistent with dioestrus and presence of ovarian tissue. Transabdominal ultrasound revealed a retroperitoneal soft tissue structure suspected to be a gonad. On exploratory laparotomy, a gonad was removed from the cranial retroperitoneum, cranial to the right kidney, after ligation of its primary blood supply. Histological examination proved the gonad to be an ovotestis. Subsequent cytogenetics revealed a 78 XX karyotype, thus confirming the diagnosis of ectopic ovotestis in a XX ovotesticular, SRY-negative, disorder of sexual development in a dog. © 2018 Blackwell Verlag GmbH.

  11. Obtaining highly excited eigenstates of the localized XX chain via DMRG-X.

    PubMed

    Devakul, Trithep; Khemani, Vedika; Pollmann, Frank; Huse, David A; Sondhi, S L

    2017-12-13

    We benchmark a variant of the recently introduced density matrix renormalization group (DMRG)-X algorithm against exact results for the localized random field XX chain. We find that the eigenstates obtained via DMRG-X exhibit a highly accurate l-bit description for system sizes much bigger than the direct, many-body, exact diagonalization in the spin variables is able to access. We take advantage of the underlying free fermion description of the XX model to accurately test the strengths and limitations of this algorithm for large system sizes. We discuss the theoretical constraints on the performance of the algorithm from the entanglement properties of the eigenstates, and its actual performance at different values of disorder. A small but significant improvement to the algorithm is also presented, which helps significantly with convergence. We find that, at high entanglement, DMRG-X shows a bias towards eigenstates with low entanglement, but can be improved with increased bond dimension. This result suggests that one must be careful when applying the algorithm for interacting many-body localized spin models near a transition.This article is part of the themed issue 'Breakdown of ergodicity in quantum systems: from solids to synthetic matter'. © 2017 The Author(s).

  12. Bad habits and bad genes: early 20th-century eugenic attempts to eliminate syphilis and associated "defects" from the United States.

    PubMed

    Wilson, Philip K

    2003-01-01

    American eugenists in the early 20th century distinguished "degenerates," including syphilitics, prostitutes, alcoholics and criminals, from the "normal" population by their particular bad habits. From eugenists' viewpoint, these bad habits were derived from bad character, a flaw that stemmed from an individual's bad genes. This essay explores how eugenists during this period characterized syphilitics and those with associated character "defects" in terms of heredity. Additionally, it examines the methods eugenists most frequently advocated to rectify these bad habits. These methods included marriage restriction, immigration control and reproductive sterilization. Overall, eugenists directed their efforts not so much at the "degenerate" as at his or her germ line.

  13. Drastic stability change of X-X mismatch in d(CXG) trinucleotide repeat disorders under molecular crowding condition.

    PubMed

    Teng, Ye; Pramanik, Smritimoy; Tateishi-Karimata, Hisae; Ohyama, Tatsuya; Sugimoto, Naoki

    2018-02-05

    The trinucleotide repeat d(CXG) (X = A, C, G or T) is the most common sequence causing repeat expansion disorders. The formation of non-canonical structures, such as hairpin structures with X-X mismatches, has been proposed to affect gene expression and regulation, which are important in pathological studies of these devastating neurological diseases. However, little information is available regarding the thermodynamics of the repeat sequence under crowded cellular conditions where many non-canonical structures such as G-quadruplexes are highly stabilized, while duplexes are destabilised. In this study, we investigated the different stabilities of X-X mismatches in the context of internal d(CXG) self-complementary sequences in an environment with a high concentration of cosolutes to mimic the crowding conditions in cells. The stabilities of full-matched duplexes and duplexes with A-A, G-G, and T-T mismatched base pairs under molecular crowding conditions were notably decreased compared to under dilute conditions. However, the stability of the DNA duplex with a C-C mismatch base pair was only slightly destabilised. Investigating different stabilities of X-X mismatches in d(CXG) sequences is important for improving our understanding of the formation and transition of multiple non-canonical structures in trinucleotide repeat diseases, and may provide insights for pathological studies and drug development. Copyright © 2018 Elsevier Inc. All rights reserved.

  14. [A historical-epistemological perspective of the ontological problem of Positivism. Positivism and psychiatry].

    PubMed

    Fantin, Juan Carlos

    2005-01-01

    The present article reviews epistemological problems related to the philosophical and scientific current known as Positivism. The revision begins with the study of the historical period during which the Logical Positivism emerges (early in the decade of 1920); and finishes with the analysis of its influence on psychiatry and its relation with other epistemological currents in the same period. The article reviews the historical and epistemological outlook at te beginning of the XX th century, when the problem of language became ontologically outstanding. The question of language remains important in the present discussions.

  15. Reformist and Feminist Views of Sport in the Early Twentieth Century.

    ERIC Educational Resources Information Center

    Bandy, Susan J.

    This paper examines the development of women's sports during the first three decades of the 20th century and compares it with the development of the women's movement during the same period. In so doing, the paper focuses on the views of female physical educators and female athletes and on their participation in sport. These views and the…

  16. A brief history of the American radium industry and its ties to the scientific community of its early twentieth century

    USGS Publications Warehouse

    Landa, E.R.

    1993-01-01

    Federally funded remedial action projects are presently underway in New Jersey and Colorado at sites containing 226Ra and other radionuclides from radium-uranium ore extraction plants that operated during the early twentieth century. They are but the latest chapter in the story of an American industry that emerged and perished in the span of three decades. Major extraction plants were established in or near Denver (CO), Pittsburgh (PA), and New York City (NY) to process radium from ore that came largely from the carnotite deposits of western Colorado and eastern Utah. The staffs of these plants included some of the finest chemists and physicists in the nation, and the highly-refined radium products found a variety of uses in medicine and industry. The discovery of high-grade pitchblende ores in the Belgian Congo and the subsequent opening of an extraction plant near Antwerp, Belgium, in 1992, however, created an economic climate that put an end to the American radium industry. The geologic, chemical, and engineering information gathered during this era formed the basis of the uranium industry of the later part of the century, while the tailings and residues came to be viewed as environmental problems during the same period.

  17. [Mercury (and...) through the centuries].

    PubMed

    Kłys, Małgorzata

    2010-01-01

    Mercury has a long history, fascinating in its many aspects. Through the centuries--from ancient times to the present day--the metal in its various forms, also known under the name "quicksilver", accompanied the man and was used for diversified purposes. Today, mercury is employed in manufacturing thermometers, barometers, vacuum pumps and explosives. It is also used in silver and gold mining processes. Mercury compounds play a significant role in dentistry, pharmaceutical industry and crop protection. The contemporary use of mercury markedly decreases, but historically speaking, the archives abound in materials that document facts and events occurring over generations and the immense intellectual effort aiming at discovering the true properties and mechanisms of mercury activity. Mercury toxicity, manifested in destruction of biological membranes and binding of the element with proteins, what disturbs biochemical processes occurring in the body, was discovered only after many centuries of the metal exerting its effect on the lives of individuals and communities. For centuries, mercury was present in the work of alchemists, who searched for the universal essence or quintessence and the so-called philosopher's stone. In the early modern era, between the 16th and 19th centuries, mercury was used to manufacture mirrors. Mercury compounds were employed as a medication against syphilis, which plagued mankind for more than four hundred years--from the Middle Ages till mid 20th century, when the discovery of penicillin became the turning point. This extremely toxic therapy resulted in much suffering, individual tragedies, chronic poisonings leading to fatalities and dramatic sudden deaths. In the last fifty years, there even occurred attempts of mentally imbalanced individuals at injecting themselves with metallic mercury, also as a performance-enhancing drug. Instances of mass mercury poisoning occurred many times in the past in consequence of eating food products

  18. Black and white body mass index values in developing nineteenth century Nebraska.

    PubMed

    Carson, Scott Alan

    2015-01-01

    Little is known about late 19th and early 20th century BMIs on the US Central Plains. Using data from the Nebraska state prison, this study demonstrates that the BMIs of dark complexioned blacks were greater than for fairer complexioned mulattos and whites. Although modern BMIs have increased, late 19th and early 20th century BMIs in Nebraska were in normal ranges; neither underweight nor obese individuals were common. Farmer BMIs were consistently greater than those of non-farmers, and farm labourer BMIs were greater than those of common labourers. The BMIs of individuals born in Plains states were greater than for other nativities, indicating that rural lifestyles were associated with better net current biological living conditions.

  19. Fumigating the Hygienic Model City: Bubonic Plague and the Sulfurozador in Early-Twentieth-Century Buenos Aires.

    PubMed

    Engelmann, Lukas

    2018-07-01

    The 1899/1900 arrival of bubonic plague in Argentina had thrown the model status of Buenos Aires as a hygienic city into crisis. Where the idea of foreign threats and imported epidemics had dominated the thinking of Argentina's sanitarians at that time, plague renewed concerns about hidden threats within the fabric of the capital's dense environment; concerns that led to new sanitary measures and unprecedented rat-campaigns supported by the large-scale application of sulphur dioxide. The article tells the story of early twentieth-century urban sanitation in Buenos Aires through the lens of a new industrial disinfection apparatus. The Aparato Marot, also known as Sulfurozador was acquired and integrated in the capital's sanitary administration by the epidemiologist José Penna in 1906 to materialise two key lessons learned from plague. First, the machine was supposed to translate the successful disinfection practices of global maritime sanitation into urban epidemic control in Argentina. Second, the machine's design enabled public health authorities to reinvigorate a traditional hygienic concern for the entirety of the city's terrain. While the Sulfurozador offered effective destruction of rats, it promised also a comprehensive - and utopian - disinfection of the whole city, freeing it from all imaginable pathogens, insects as well as rodents. In 1910, the successful introduction of the Sulfurozador encouraged Argentina's medico-political elite to introduce a new principle of 'general prophylaxis'. This article places the apparatus as a technological modernisation of traditional sanitary practices in the bacteriological age, which preserved the urban environment - 'el terreno' - as a principal site of intervention. Thus, the Sulfurozador allowed the 'higienistas' to sustain a long-standing utopian vision of all-encompassing social, bodily and political hygiene into the twentieth century.

  20. Letter "To the Yakut Intelligentsia" by A. E. Kulakovsky: Setting and Features of the Problem of Survival of Indigenous Peoples of the North in the Early 20th Century

    ERIC Educational Resources Information Center

    Sivtseva-Maksimova, Praskovia Vasilevna

    2016-01-01

    The relevance of the study is determined by the increasing interest in the new interpretations of social issues of living in the early 20th century, and from this perspective, in the scientific heritage of A. E. Kulakovsky (1877-1926) as an original thinker, who worried about the fate of the indigenous people inhabiting a large territory of the…

  1. INTEREST IN ASTROLOGY AND PHRENOLOGY OVER TWO CENTURIES: A GOOGLE NGRAM STUDY.

    PubMed

    Genovese, Jeremy E C

    2015-12-01

    The Google Ngram Viewer shows the frequency of words in a large corpus of books over two centuries. In this study, the names of two pseudosciences, astrology and phrenology, were compared. An interesting pattern emerged. While the level of interest in astrology remained relatively stable over the course of two centuries, interest in phrenology rose rapidly in the early 1800s but then declined. Reasons for this pattern are discussed.

  2. How to manage a revolution: Isaac Newton in the early twentieth century

    PubMed Central

    Clarke, Imogen

    2014-01-01

    In the first half of the twentieth century, dramatic developments in physics came to be viewed as revolutionary, apparently requiring a complete overthrow of previous theories. British physicists were keen to promote quantum physics and relativity theory as exciting and new, but the rhetoric of revolution threatened science's claim to stability and its prestigious connections with Isaac Newton. This was particularly problematic in the first decades of the twentieth century, within the broader context of political turmoil, world war, and the emergence of modernist art and literature. This article examines how physicists responded to their cultural and political environment and worked to maintain disciplinary connections with Isaac Newton, emphasizing the importance of both the old and the new. In doing so they attempted to make the physics ‘revolution’ more palatable to a British public seeking a sense of permanence in a rapidly changing world.

  3. Love, madness and social order: love melancholy in France and England in the late sixteenth and early seventeenth centuries.

    PubMed

    Altbauer-Rudnik, Michal

    2006-01-01

    The concept of "illness's social course" can be approached from two stand-points. We can trace both the way the social world shapes the course of an illness and the way an illness' symptoms shape the social world. The purpose of this study is to locate the specific illness of love melancholy in a specific historical and social context, namely that of France and England in the late sixteenth and early seventeenth centuries, in order to explain the intense discussion on the disorder during that period. This attempt is done with respect to the two dimensions of the concept of "illness' social course" and in the light of constructivist commentary on psychological disorders, which regards them as local stress idioms shaped by a specific social and cultural context.

  4. An Account of Stellar Spectroscopy and John S. Plaskett’s Leadership within Early 20th-Century Astrophysics in Canada

    NASA Astrophysics Data System (ADS)

    Ihor Oakes, Andrew

    2017-01-01

    From the perspective of the science of astronomy, the interpretation of the light spectrum was a fundamental development in the chemical analysis of celestial starlight. The breakthrough discovery with the application of spectroscopy in 1859, inaugurated a new period in astronomy that evolved into astrophysics. It launched a continuing episode of new astronomy that was later embraced in early 20th-century Canada where it was spearheaded by Canadian physicist and scientist, John S. Plaskett (1865-1941). The research work of John Plaskett at the Dominion Observatory in Ottawa, Ontario, from 1903 and, later, the Dominion Astrophysical Observatory in Victoria, British Columbia, from 1918, brought international recognition to Canada’s early efforts in astrophysics. Plaskett’s determination and personal boldness led to the establishment of a small cadre of Canadian astronomers who worked on their astrophysical research programs under Plaskett as their supervisor. Despite its small population at the time and a relatively infinitesimal number of professional astronomers, Canada did become recognized for its early spectrographic work in astrophysics, which was due to developing a professional status equal to its international colleagues. Plaskett improved the techniques of celestial spectroscopy during his scientific work at the Dominion Observatory and, again later, at its newly-built sister facility, the Dominion Astrophysical Observatory. Historically, Plaskett found himself to be the right person, in the right place, at the right time, and with the right temperament during the review period spanning 1903 to 1935.

  5. Care of the insane in Lübeck during the 17th and 18th centuries.

    PubMed

    Dilling, Horst; Thomsen, Hans Peter; Hohagen, Fritz

    2010-12-01

    Only selected aspects of the history of the House of the Poor Insane in the Hanseatic Free City of Lübeck have been studied to date.This article presents the results of an entire source study of this small institution in the 17th and 18th centuries, and briefly also during the next 40 years after the opening of a new building. In addition to the minute-book of the Governors, now kept in the Lübeck Municipal Archives, the results are based primarily on the account-books,which illustrate the institution's social history and activities. Examples are given. During most of the 17th century, the House was generally rather like a prison for the insane, but at the end of this century and in the early 18th there was a reform phase.This was followed by phases of repression and 'containment' at the end of the 18th century and in the early 19th century, before a renewed reform by the medical profession.The findings for Lübeck are compared with the development of inpatient care in institutions elsewhere, and the decisive factors in Lübeck are discussed.

  6. Empiricism and Rationalism in Nineteenth-Century Histories of Philosophy.

    PubMed

    Vanzo, Alberto

    2016-01-01

    This paper traces the ancestry of a familiar historiographical narrative, according to which early modern philosophy was marked by the development of empiricism, rationalism, and their synthesis by Kant. It is often claimed that this narrative became standard in the nineteenth century because of the influence of Thomas Reid, Kant and his disciples, or German and British idealists. I argue that the narrative became standard at the turn of the twentieth century. Among the factors that allowed it to become standard are its aptness to be adopted by philosophers of the most diverse persuasions, its simplicity and suitability for teaching.

  7. Political Life in Eighteenth-Century Virginia. Essays from Colonial Williamsburg. The Foundations of America.

    ERIC Educational Resources Information Center

    Greene, Jack P.

    This book explores the history of the Virginia colony from the early 18th century to the time of the signing of the Declaration of Independence. Virginia, the oldest and most prosperous of Great Britain's North American colonies, assumed a leading role in the political life of the colonies. Some in 17th century Virginia had seen political…

  8. Teleportation via thermally entangled states of a two-qubit Heisenberg XX chain

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yeo Ye

    2002-12-01

    Recently, entanglement teleportation has been investigated by Lee and Kim [Phys. Rev. Lett. 84, 4236 (2000)]. In this paper we study entanglement teleportation via two separate thermally entangled states of a two-qubit Heisenberg XX chain. We established the condition under which the parameters of the model have to satisfy in order to teleport entanglement. The necessary minimum amount of thermal entanglement for some fixed strength of exchange coupling is a function of the magnetic field and the temperature.

  9. Freedom to divorce or protection of marriage? The divorce laws in Denmark, Norway, and Sweden in the early twentieth century.

    PubMed

    Le Bouteillec, Nathalie; Bersbo, Zara; Festy, Patrick

    2011-01-01

    In the period 1909-1927, new laws concerning divorce and marriage were enacted by the Scandinavian countries. Both at the time and more recently, these laws were considered as "liberal" as they promoted greater freedom to divorce based on individuality and gender equality. In this article, the authors first analyze the changes in these Family laws in the early twentieth century. Then, the authors study the effect of these laws on divorce and marriage patterns. As these laws did not modify the trend in divorce rates, the authors ask why this was the case. The authors' conclusions are that the laws were more concerned with preserving the sanctity of marriage and maintaining social order than with promoting individual freedom and gender equality.

  10. [Molecular and cytogenetic characterization of six 46, XX males due to translocations between the short arms of X and Y chromosomes].

    PubMed

    Xing, Ya; Ji, Xing; Xiao, Bing; Jiang, Wen-ting; Hu, Qin; Hu, Juan; Cao, Ying; Tao, Jiong

    2012-08-01

    To characterize molecular and cytogenetic abnormalities in six 46, XX males, and to investigate the clinical manifestations and underlying mechanisms in such patients. Clinical data of six XX male patients were collected. Karyotyping, multiple polymerase chain reaction (PCR) and fluorescence in situ hybridization (FISH) were utilized to detect and locate the sex determining region (SRY) gene. PCR and FISH showed that all patients were SRY-positive XX males. All patients have their SRY gene located at the tip of derivative X chromosomes, which have resulted from translocation between short arms of X and Y chromosomes. High resolution karyotyping at 550-750 band level has revealed that the translocation breakpoints were at Xp22.33 and Yp11.2 in three patients. In the remaining patients, the breakpoints were either at Xp22.32 and Yp11.31 or Xp22.31 and Yp11.2. The breakpoints at Xp22.32, Xp22.31 and Yp11.31 were rarely reported. Genotype-phenotype correlation analysis indicated that the clinical manifestations were age-specific. Four adult patients have come to clinical attention due to infertility, with typical features including azoospermia and testis dysgenesis, whereas poorly developed secondary sexual characteristics and short stature were main complaints of adolescence patients, and short stature was the sole symptom in a child patient. Combined karyotyping, PCR and FISH are important for the analysis of XX males. Particularly, high resolution karyotyping is valuable for the refinement of chromosome breakpoints and detailed analysis of genotype-phenotype correlation.

  11. A case of 46,XX dysgenesis and marked tall stature; the need for caution in interpreting array comparative genomic hybridization (CGH).

    PubMed

    Narayanan, Vidya Kanamkote; Kharbanda, Mira; Donaldson, Malcolm

    2016-12-01

    Gonadal dysgenesis with an apparently normal 46,XX karyotype is a rare cause of hypergonadotrophic hypogonadism. Tall stature is not a widely recognized association. A 15-year-old girl presented with primary amenorrhoea. Examination showed a non-dysmorphic girl of normal intellect with no breast development (Tanner stage B1P4A1) who was tall compared with her parents: height standard deviation score (SDS) +1.56 vs. midparental height of +0.23 SDS, and slim build (weight -0.13 SDS). Investigations showed a 46,XX karyotype, elevated gonadotropins (FSH 119 and LH 33.7 IU/L), serum estradiol <5 pmol/L, uterine length 3.75 cm with cylindrical shape, and absent ovaries on ultrasound. Initially, a 364055-bp deletion on Xp21.2 was reported on array CGH. However, repeat analysis using BlueGnome CytoChip ISCA 4x180k v2.0 array was normal. With oral ethinyl estradiol induction puberty progressed to B4P4A2 but aged 18.4 years, the patient was remarkably tall with height SDS +2.88, weight SDS +0.97. Caution is needed in interpreting small changes with array CGH, particularly with the older assays. We postulate that the genetic change causing 46,XX gonadal dysgenesis in our patient may have also resulted in unsuppressed somatic growth. More critical height assessment, including parental height measurement, of future patients with 46,XX gonadal dysgenesis is recommended in order to determine whether or not a true association with tall stature may be present in certain cases.

  12. Discovery of DLT18h/AT 2018xx with PROMPT and the DLT40 Survey

    NASA Astrophysics Data System (ADS)

    Sand, D.; Valenti, S.; Wyatt, S.; Bostroem, K. A.; Reichart, D. E.; Haislip, J. B.; Kouprianov, V.

    2018-02-01

    We report the discovery of DLT18h/AT 2018xx, which was first imaged on 2018 Feb 21.1 (UT) at R 17.2 mag during the ongoing D < 40 Mpc (DLT40) one day cadence supernova search, which uses data from the PROMPT5 0.41m telescope located at CTIO.

  13. Maltreatment of people with serious mental illness in the early 20th century: a focus on Nazi Germany and eugenics in America.

    PubMed

    Fischer, Bernard A

    2012-12-01

    Prejudice and stigma against people with mental illness can be seen throughout history. The worst instance of this prejudice was connected to the rise of the eugenics movement in the early 20th century. Although the Nazi German T-4 program of killing people with mental illness was the most egregious culmination of this philosophy, the United States has its own dark eugenics history-nearing a slippery slope all too similar to that of the Nazis. Mental health care clinicians need to examine this period to honor the memory of the victims of eugenics and to guarantee that nothing like this will ever happen again.

  14. Climate and history in the late 18th and early 19th centuries

    NASA Astrophysics Data System (ADS)

    Feldman, Theodore S.

    As in many areas of human knowledge, the notion of climate acquired a deeper historical content around the turn of the 19th century. Natural philosophers, geographers, and others became increasingly aware of climate's own history and its relation to human, plant and animal, and Earth history. This article examines several aspects of this “historicization” of climate.The lively 18th century discussion of the influence of climate on society is well known. Montesquieu is its most famous representative, but Voltaire, Hume, Kant, and others also participated. Their debate was literary more than scientific, their goal the understanding of man, not climate. Partly for this reason and partly because of the lack of good information on climates, they made no attempt to gather substantial climatic data. In fact, the importance of systematically collecting reliable data was scarcely understood in any area of natural philosophy before the last decades of the century [Cf. Frängsmyr et al., 1990; Feldman, 1990]. Instead, participants in the debate repeated commonplaces dating from Aristotle and Hippocrates and based their conclusions on unreliable reports from travelers. As Glacken wrote of Montesquieu, “his dishes are from old and well-tested recipes” [Glacken, 1967, chapter 12]. This is not to say that the debate over climatic influence was not significant—only that its significance lay more in the history of man than in the atmospheric sciences.

  15. High-throughput sequencing analyses of XX genital ridges lacking FOXL2 reveal DMRT1 up-regulation before SOX9 expression during the sex-reversal process in goats.

    PubMed

    Elzaiat, Maëva; Jouneau, Luc; Thépot, Dominique; Klopp, Christophe; Allais-Bonnet, Aurélie; Cabau, Cédric; André, Marjolaine; Chaffaux, Stéphane; Cribiu, Edmond-Paul; Pailhoux, Eric; Pannetier, Maëlle

    2014-12-01

    FOXL2 loss of function in goats leads to the early transdifferentiation of ovaries into testes, then to the full sex reversal of XX homozygous mutants. By contrast, Foxl2 loss of function in mice induces an arrest of follicle formation after birth, followed by complete female sterility. In order to understand the molecular role of FOXL2 during ovarian differentiation in the goat species, putative FOXL2 target genes were determined at the earliest stage of gonadal sex-specific differentiation by comparing the mRNA profiles of XX gonads expressing the FOXL2 protein or not. Of these 163 deregulated genes, around two-thirds corresponded to testicular genes that were up-regulated when FOXL2 was absent, and only 19 represented female-associated genes, down-regulated in the absence of FOXL2. FOXL2 should therefore be viewed as an antitestis gene rather than as a female-promoting gene. In particular, the key testis-determining gene DMRT1 was found to be up-regulated ahead of SOX9, thus suggesting in goats that SOX9 primary up-regulation may require DMRT1. Overall, our results equated to FOXL2 being an antitestis gene, allowing us to propose an alternative model for the sex-determination process in goats that differs slightly from that demonstrated in mice. © 2014 by the Society for the Study of Reproduction, Inc.

  16. Early Childhood Care and Education in Kenya

    ERIC Educational Resources Information Center

    Mbugua, Tata J.

    2004-01-01

    Recent years have seen a global endeavor to prioritize early childhood care and education as a foundation for later learning and development, as evidenced by the Global Guidelines for Early Childhood Education and Care in the 21st Century (Association for Childhood Education International/World Organization for Early Childhood, 1999). Such efforts…

  17. Should male gender assignment be considered in the markedly virilized patient With 46,XX and congenital adrenal hyperplasia?

    PubMed

    Lee, Peter A; Houk, Christopher P; Husmann, Douglas A

    2010-10-01

    We assess the outcome in 46,XX men with congenital adrenal hyperplasia who were born with Prader 4 or 5 genitalia and assigned male gender at birth. After receiving institutional review board approval and subject consent we reviewed the medical records of 12 men 35 to 69 years old with 46,XX congenital adrenal hyperplasia, of whom 6 completed social and gender issue questionnaires. All subjects were assigned male gender at birth, were diagnosed with virilizing congenital adrenal hyperplasia at age greater than 3 years and indicated a male gender identity with sexual orientation to females. Ten of the 12 subjects had always lived as male and 2 who were reassigned to female gender in childhood subsequently self-reassigned as male. Nine of the 12 men had long-term female partners, including 7 married 12 years or more. The 3 subjects without a long-term female partner included 1 priest, 1 who was reassigned female gender, married, divorced and self-reassigned as male, and 1 with a girlfriend and sexual activity. All except the priest and the subject who was previously married when female indicated a strong libido and frequent orgasmic sexual activity. Responses to self-esteem, masculinity, body image, social adjustment and symptom questionnaires suggested adjustments related to the extent of familial and social support. Outcome data on severely masculinized 46,XX patients with congenital adrenal hyperplasia who were assigned male gender at birth indicate male gender identity in adulthood with satisfactory male sexual function in those retaining male genitalia. In men who completed questionnaires results were poorer in those lacking familial/social support. Male gender of rearing may be a viable option for parents whose children are born with congenital adrenal hyperplasia, a 46,XX karyotype and male genitalia, although positive parental and other support, and counseling are needed for adjustment. Copyright © 2010 American Urological Association Education and Research

  18. Landscapes and Literature: A Look at the Early Twentieth Century Rural South.

    ERIC Educational Resources Information Center

    Mitchell, Martin

    1998-01-01

    Examines samples of southern literature from the first half of the century that can be used to understand, geographically, the rural landscapes of the Coastal Plain from North Carolina through Mississippi. Addresses the socioeconomic imprint upon the land, climatic perceptions, and the role of the forest in literary works. (CMK)

  19. Contested Citizenship: Public Schooling and Political Changes in Early Nineteenth Century Switzerland

    ERIC Educational Resources Information Center

    Bru¨hwiler, Ingrid

    2017-01-01

    This article examines public education and the establishment of the nation-state in the first half of the nineteenth century in Switzerland. Textbooks, governmental decisions, and reports are analyzed in order to better understand how citizenship is depicted in school textbooks and whether (federal) political changes affected the image of the…

  20. The management century.

    PubMed

    Kiechel, Walter

    2012-11-01

    In 1886, addressing the nascent American Society of Mechanical Engineers, Henry R. Towne proposed that "the management of works" be considered a modern art--thereby heralding the Management Century, when management as we know it came into being and shaped the world in which we work. Kiechel, a past editorial director of Harvard Business Publishing, elucidates the three eras that punctuate this period: the years leading up to World War II, during which scientific exactitude gave wings to a new managerial elite; the early postwar decades, managerialism's apogee of self-confidence and a time when wartime principles of strategy were adapted, sometimes ruthlessly, to the running of companies; and the 1980s to the present, years that saw fast-moving changes, disequilibrium, and a servitude to market forces but also ushered in globalism, unprecedented innovation, and heightened expectations about how workers are to be treated. Along the way he examines the contributions of thinkers such as Frederick Taylor, Elton Mayo, Peter Drucker, and Michael Porter. What lies ahead? Perhaps the biggest challenge facing the 21st-century company, Kiechel posits, is to truly free the spark of human imagination from the organization's tidal pull toward the status quo. There's almost always a better way, he concludes--and management will continue to seek it.

  1. A lack of association between polymorphisms of three positional candidate genes (CLASP2 , UBP1, and FBXL2) and canine disorder of sexual development (78,XX; SRY -negative).

    PubMed

    Salamon, Sylwia; Nowacka-Woszuk, Joanna; Szczerbal, Izabela; Dzimira, Stanisław; Nizanski, Wojciech; Ochota, Malgorzata; Switonski, Marek

    2014-01-01

    A disorder of sexual development (DSD) of dogs with a female karyotype, missing SRY gene, and presence of testicles or ovotestes is quite commonly diagnosed. It is suggested that this disorder is caused by an autosomal recessive mutation; however, other models of inheritance have not been definitely ruled out. In an earlier study it was hypothesized that the mutation may reside in a pericentromeric region of canine chromosome 23 (CFA23). Three positional candidate genes (CLASP2, UBP1, and FBXL2) were selected in silico in the search for polymorphisms in 7 testicular or ovotesticular XX DSD dogs, 8 XX DSD dogs of unknown cause (SRY-negative, with enlarged clitoris and unknown histology of gonads), and 29 normal female dogs as a control group. Among the 15 molecularly studied dogs with enlarged clitoris there were 3 new cases of testicular or ovotesticular XX DSD and 4 new cases of XX DSD with unknown cause (histology of the gonads unknown). Altogether, 11 (including 10 novel) polymorphisms in 5'- and 3'-flanking regions of the studied genes were found. The distribution analysis of these polymorphisms showed no association with the DSD phenotypes. Thus, it was concluded that the presence of the causative mutation for testicular or ovotesticular XX DSD in the pericentromeric region of CFA23 is unlikely. © 2014 S. Karger AG, Basel.

  2. Combined Leydig cell and Sertoli cell dysfunction in 46,XX males lacking the sex determining region Y gene

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Turner, B.; Vordermark, J.S.; Fechner, P.Y.

    1995-07-03

    We have evaluated 3 individuals with a rare form of 46,XX sex reversal. All of them had ambiguous external genitalia and mixed wolffian and muellerian structures, indicating both Leydig cell and Sertoli cell dysfunction, similar to that of patients with true hermaphroditism. However, gonadal tissue was not ovotesticular but testicular with varying degrees of dysgenesis. SRY sequences were absent in genomic DNA from peripheral leukocytes in all 3 subjects. Y centromere sequences were also absent, indicating that testis development did not occur because of a low level mosaicism of Y-bearing cells. The subjects in this report demonstrate that there ismore » a continuum in the extent of the testis determination in SRY-negative 46,XX sex reversal, ranging from nearly normal to minimal testicular development. 20 refs.« less

  3. High-efficiency and high-reliability 9xx-nm bars and fiber-coupled devices at Coherent

    NASA Astrophysics Data System (ADS)

    Zhou, Hailong; Kennedy, Keith; Weiss, Eli; Li, Jun; Anikitchev, Serguei; Reichert, Patrick; Du, Jihua; Schleuning, David; Nabors, David; Reed, Murray; Toivonen, Mika; Lehkonen, Sami; Haapamaa, Jouko

    2006-02-01

    Ongoing optimization of epitaxial design within Coherent device engineering has led to a family of high power-conversion-efficiency (PCE) products on conductively cooled packages (CCP) and fiber array packages (FAP). At a 25°C heat sink temperature, the PCE was measured at 71.5% with 75W CW output power on 30% fill-factor (FF) bars with passive cooling. At heat sink temperatures as high as 60°C the PCE of these bars is still maintained above 60%. Powered by such high efficiency 9xx nm diodes, Coherent FAP products have consistently exceeded 55% PCE up to 50W power levels, with 62% PCE demonstrated out of the fiber. High linear-power-density (LPD) operation of 100μm x 7-emitter bars at LPD = 80 mW/μm was also demonstrated. Bars with 7-emitter were measured up to 140W QCW power before catastrophic optical mirror damage (COMD) occurred, which corresponds to a COMD value of 200mW/μm or 2D facet power density of 29.4 MW/cm2. Leveraging these improvements has enabled high power FAPs with >90W CW from an 800μm-diameter fiber bundle. Extensive reliability testing has already accumulated 400,000 total real-time device hours at a variety of accelerated and non-accelerated operating conditions. A random failure rate <0.5% per kilo-hours and gradual degradation rate <0.4% per kilo-hours have been observed. For a 30% FF 50W CW 9xx nm bar, this equates to >30,000 hours of median lifetime at a 90% confidence level. More optimized 30% FF 9xx nm bars are under development for power outputs up to 80W CW with extrapolated median lifetimes greater than 20,000 hours.

  4. Harvard Humanities Students Discover the 17th Century Online

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2007-01-01

    This article profiles Harvard professor Stephen Greenblatt's new course, "Travel and Transformation in the Early 17th Century." The product of an intense, months-long collaboration between computing specialists, graduate students, librarians, and scholars, the course makes innovative use of all the tools and technical know-how a major university…

  5. [Louis XIV's Ginseng: Shaping of Knowledge on an Herbal Medicine in the Late 17th and the Early 18th Century France].

    PubMed

    Lee, Hye-Min

    2016-04-01

    This article aims to investigate the shaping of knowledge and discourse on ginseng, especially among physicians and botanists, since its introduction to France from the 17th century until the early 18th century. In France, knowledge on herbal medicine, including that of ginseng, was shaped under the influence of the modern state's policy and institution: mercantilism and the Académie royale des sciences. The knowledge of herbal medicine developed as an important part of the mercantilist policy supported systematically by the Académie. The East Asian ginseng, renowned as a panacea, was first introduced into France in the 17th century, initially in a roundabout way through transportation and English and Dutch publications of travel tales from various foreign countries. The publication activity was mainly conducted by Thévenot company with the intention to meet the needs of French mercantilism promoted by Colbert. It also implied interests on medicine in order to bolster the people's health. The Thévenot company's activity thus offered vital information on plants and herbs abroad, one of which was ginseng. Furthermore, with Louis XIV's dispatching of the Jesuit missionaries to East Asia, the Frenchmen were able to directly gather information on ginseng. These information became a basis for research of the Académie. In the Académie, founded in 1666 by Colbert, the king's physicians and botanists systematically and collectively studied on exotic plants and medical herbs including ginseng. They were also key figures of the Jardin du Roi. These institutions bore a striking contrast to the faculty of medicine at the University of Paris which has been a center of the traditional Galenic medicine. The research of the Académie on ginseng was greatly advanced, owing much to the reports and samples sent from China and Canada by Jartoux, Sarrazin, and Lapitau. From the early 18th century, the conservative attitude of the University of Paris, which was a stronghold of

  6. Unwelcome Stranger to the System: Vocational Education in Early Twentieth-Century China

    ERIC Educational Resources Information Center

    Schulte, Barbara

    2013-01-01

    Both in China and internationally, educators and policy makers claim that vocational education and training (VET) is essential for the sound economic development of a country and the physical and social well-being of its population. However, China looks back upon a century-long history of rejection when it comes to popularising VET, despite…

  7. Spotlight of a Century of Educational Reform in England.

    ERIC Educational Resources Information Center

    Henry, Thomas B.

    During the past 100 years, there has been an evolution in publicly funded education in England. This report provides a historical perspective for recent reforms and spotlights three related areas. The first section describes the early 19th-century Newcastle Commission's efforts to design a system of sound and cheap elementary education for…

  8. Evidence of a louse-borne outbreak involving typhus in Douai, 1710-1712 during the war of Spanish succession.

    PubMed

    Nguyen-Hieu, Tung; Aboudharam, Gérard; Signoli, Michel; Rigeade, Catherine; Drancourt, Michel; Raoult, Didier

    2010-10-27

    The new field of paleomicrobiology allows past outbreaks to be identified by testing dental pulp of human remains with PCR. We identified a mass grave in Douai, France dating from the early XVIII(th) century. This city was besieged during the European war of Spanish succession. We tested dental pulp from 1192 teeth (including 40 from Douai) by quantitative PCR (qPCR) for R. prowazekii and B. quintana. We also used ultra-sensitive suicide PCR to detect R. prowazekii and genotyped positive samples. In the Douai remains, we identified one case of B. quintana infection (by qPCR) and R. prowazekii (by suicide PCR) in 6/21 individuals (29%). The R. prowazekii was genotype B, a genotype previously found in a Spanish isolate obtained in the first part of the XX(th) century. Louse-borne outbreaks were raging during the XVIII(th) century; our results support the hypothesis that typhus was imported into Europe by Spanish soldiers from America.

  9. Impact of climate changes on population vital activities in Russia in the early 21st century

    NASA Astrophysics Data System (ADS)

    Zolotokrylin, A. N.; Vinogradova, V. V.; Titkova, T. B.; Cherenkova, E. A.; Bokuchava, D. D.; Sokolov, I. A.; Vinogradov, A. V.; Babina, E. D.

    2018-01-01

    The study substantiates the approach to the assessment of impact of climate change on vital activities of population in Russia in the face of increasing climate extremes. The obtained results reveal the occurrence of the essential climate extreme events over the period 1991-2013 in Russia that are vital for population activities. Annual amounts of interdiurnal temperature differences and pressure were calculated. Propagation of heat and cold waves, trends and frequencies of daily precipitation extremes were evaluated. The map “Zoning the territory of the Russian Federation by natural living conditions of the population” adapted for modern climate (2001-2010), illustrates the climate changes in the early 21st century. The modern warming of climate has led to a significant easing of discomfort in the territory of Russia. The steady decline of the absolutely unfavorable zone resulted from the expansion of less unfavorable areas is observed, especially in the Northern and Arctic regions. In the south the boundary of unfavorable territories shifts toward the north. It results in the expansion of the conditionally unfavorable area in West Siberia and in the south of East Siberia. In European Russia the favorable area expands and shifts far to the northern regions.

  10. Understanding China's Curriculum Reform for the 21st Century

    ERIC Educational Resources Information Center

    Law, Wing-Wah

    2014-01-01

    This article uses curriculum-making frameworks to analyse and reconstruct the Chinese curriculum-making model and unpack the dynamics, complexity and constraints of China's curriculum reform since the early 1990s. It argues that curriculum reform is China's main human capital development strategy for coping with the challenges of the 21st century,…

  11. From research to policy and practice: the School of the 21st Century.

    PubMed

    Zigler, Edward; Finn-Stevenson, Matia

    2007-04-01

    Current education reform policies focus on raising academic achievement and ensuring that all students have access to high-quality education. Because the achievement gap is apparent even before children enter school, the authors believe that education reform must encompass the early childhood years. The current dialogue about universal preschool presents an opportunity to address the need for a national system for early care and education. The authors believe this system should provide quality child care and preschool experiences for all children and embrace a whole-child approach that nurtures not only cognitive development but physical and mental health and social-emotional behaviors that are also important to successful schooling. The School of the 21st Century provides an example of an effective early care and education system using the public schools. The authors' work with the School of the 21st Century shows that schools can provide high-quality, developmentally appropriate care and that these programs benefit later school performance. 2007 APA, all rights reserved

  12. Diabetes insipidus: celebrating a century of vasopressin therapy.

    PubMed

    Qureshi, Sana; Galiveeti, Sneha; Bichet, Daniel G; Roth, Jesse

    2014-12-01

    Diabetes mellitus, widely known to the ancients for polyuria and glycosuria, budded off diabetes insipidus (DI) about 200 years ago, based on the glucose-free polyuria that characterized a subset of patients. In the late 19th century, clinicians identified the posterior pituitary as the site of pathology, and pharmacologists found multiple bioactivities there. Early in the 20th century, the amelioration of the polyuria with extracts of the posterior pituitary inaugurated a new era in therapy and advanced the hypothesis that DI was due to a hormone deficiency. Decades later, a subset of patients with polyuria unresponsive to therapy were recognized, leading to the distinction between central DI and nephrogenic DI, an early example of a hormone-resistant condition. Recognition that the posterior pituitary had 2 hormones was followed by du Vigneaud's Nobel Prize winning isolation, sequencing, and chemical synthesis of oxytocin and vasopressin. The pure hormones accelerated the development of bioassays and immunoassays that confirmed the hormone deficiency in vasopressin-sensitive DI and abundant levels of hormone in patients with the nephrogenic disorder. With both forms of the disease, acquired and inborn defects were recognized. Emerging concepts of receptors and of genetic analysis led to the recognition of patients with mutations in the genes for 1) arginine vasopressin (AVP), 2) the AVP receptor 2 (AVPR2), and 3) the aquaporin 2 water channel (AQP2). We recount here the multiple skeins of clinical and laboratory research that intersected frequently over the centuries since the first recognition of DI.

  13. Goethe's Ottilie: an early 19th century description of anorexia nervosa.

    PubMed Central

    Bhanji, S; Jolles, F E; Jolles, R A

    1990-01-01

    The view that the prevalence of anorexia nervosa is influenced by social attitudes and customs is a popular one. Unfortunately the scarcity of medical accounts prior to the later decades of the last century make it difficult if not impossible to estimate the prevalence of anorexia nervosa at various periods in history. The authors present the history of one of Goethe's literary heroines and suggest that similar studies could throw some light on the epidemiology of anorexia nervosa in the past. PMID:2213809

  14. 78 FR 29131 - Solar Star California XX, LLC; Supplemental Notice that Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1442-000] Solar Star California XX, LLC; Supplemental Notice that Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Solar Star...

  15. Quantifying early 17th century changes in Chesapeake Bay estuarine carbon dynamics from James River, VA oyster geochemistry

    NASA Astrophysics Data System (ADS)

    Grimm, B. L.; Spero, H. J.; Harding, J. M.

    2012-12-01

    same shells provide seasonal signals and also show an offset from modern that is consistent with drought conditions during the early 17th century. These high fidelity records allow for a direct, high-resolution comparison of the residence time of carbon in the environment immediately prior to European colonization and during the first century of land use change in mid-Atlantic North America.

  16. Novel Familial Variant of the Desert Hedgehog Gene: Clinical Findings in Two Sisters with 46,XY Gonadal Dysgenesis or 46,XX Karyotype and Literature Review.

    PubMed

    Baldinotti, Fulvia; Cavallaro, Tiziana; Dati, Eleonora; Baroncelli, Giampiero I; Bertini, Veronica; Valetto, Angelo; Massart, Francesco; Fabrizi, Gian Maria; Zanette, Giampietro; Peroni, Diego; Bertelloni, Silvano

    2018-01-01

    In humans, Desert Hedgehog (DHH) gene mutations are a very rare cause of 46,XY gonadal dysgenesis (GD), eventually associated with peripheral neuropathy. Clinical records of 12 patients with 46,XY GD and unknown genetic background were reviewed and a 46,XY woman with peripheral neuropathy was individuated. Her 46,XX sister affected by similar neuropathy was also investigated. Genomic DNA was extracted and DHH exons sequenced and analyzed. A comparative genomic hybridization array was also performed. In both the 46,XY and 46,XX sisters, a homozygous c.554C>A mutation in exon 2 of the DHH gene was found, determining a premature termination codon (p.Ser 185*). Heterozygous consanguineous carrier parents showed neither reproductive problems nor peripheral neuropathy. In the proband and her sister, a 499-kb duplication in 9p22.1 was also found. A 46,XY European woman with 46,XY GD and a novel homozygous DHH pathogenic variant is reported, confirming that this gene plays a key role in male gonadal development. Her 46,XX sister, harboring the same mutation, showed normal internal and external female phenotype. Thus, DHH seems not to be involved in the ovarian development pathway or its postpubertal function. Homozygous DHH mutations cause a specific peripheral neuropathy in humans with both 46,XY and 46,XX karyotypes. © 2018 S. Karger AG, Basel.

  17. [Sanitary and epidemiological conditions in the Lodz region during the period of the second Polish Republic in the XIX and XX centuries].

    PubMed

    Sadowska, Jolanta

    2005-01-01

    Throughout history of European agglomerations in the nineteenth and twentieth century the relation between expanding industry and worsening sanitary and epidemiological conditions was seen. These changes, having great impact on public health, were investigated in the present study. Problems related to sanitary and epidemiological conditions in Lodz first emerged during the Russian occupation of Poland in the XIX century. The Russian Governing Council was not overseeing sanitary conditions of the city, and transferred this responsibility to the industrial bourgeoisie of Lodz. In this situation, uncontrolled development of the industry led to serious deterioration in natural environment and increase of risk for acute and chronic infectious diseases. Improvement of the sanitary situation in Lodz commenced in the period of the Second Polish Republic (1918-1939). Sanitary Divisions were created at the Lodz Department of Public Health. Activities in this Department involved, among others, detailed epidemiological examination of potable water, the investigation of manufacturing processes, retail and wholesale groceries, hygienic conditions of public housing. The activity and interventions of Sanitary Divisions contributed substantially to a decrease of incidence of various diseases and improvement of living conditions of the Lodz populations. The improvement of sanitary and epidemiological conditions in Lodz after 1918 was mainly related to the construction of water supply and sewage systems. This led to an approximation of the urban standards of this 500,000 population agglomeration to European standards.

  18. The How and Why of Teaching Singing Schools in Eighteenth Century America.

    ERIC Educational Resources Information Center

    Britton, Allen P.

    1989-01-01

    Looks at eighteenth century U.S. tunebooks to discover the philosophies, the instructional materials, and the methods of early music and singing masters. Uses excerpts from tunebooks to illustrate approaches made to music reading and performance practice. (LS)

  19. Early Rockets

    NASA Image and Video Library

    2004-04-15

    During the 19th century, rocket enthusiasts and inventors began to appear in almost every country. Some people thought these early rocket pioneers were geniuses, and others thought they were crazy. Claude Ruggieri, an Italian living in Paris, apparently rocketed small animals into space as early as 1806. The payloads were recovered by parachute. As depicted here by artist Larry Toschik, French authorities were not always impressed with rocket research. They halted Ruggieri's plans to launch a small boy using a rocket cluster. (Reproduced from a drawing by Larry Toschik and presented here courtesy of the artist and Motorola Inc.)

  20. A three-dimensional color space from the 13th century

    PubMed Central

    Smithson, Hannah E.; Dinkova-Bruun, Greti; Gasper, Giles E. M.; Huxtable, Mike; McLeish, Tom C. B.; Panti, Cecilia

    2012-01-01

    We present a new commentary on Robert Grosseteste’s De colore, a short treatise that dates from the early 13th century, in which Grosseteste constructs a linguistic combinatorial account of color. In contrast to other commentaries (e.g., Kuehni & Schwarz, Color Ordered: A Survey of Color Order Systems from Antiquity to the Present, 2007, p. 36), we argue that the color space described by Grosseteste is explicitly three-dimensional. We seek the appropriate translation of Grosseteste’s key terms, making reference both to Grosseteste’s other works and the broader intellectual context of the 13th century, and to modern color spaces. PMID:22330399

  1. Transatlantic Irritability: Brunonian sociology, America and mass culture in the nineteenth century.

    PubMed

    Budge, Gavin

    2014-01-01

    The widespread influence exerted by the medical theories of Scottish doctor, John Brown, whose eponymously named Brunonianism radically simplified the ideas of his mentor, William Cullen, has not been generally recognised. However, the very simplicity of the Brunonian medical model played a key role in ensuring the dissemination of medical ideas about nervous irritability and the harmful effects of overstimulation in the literary culture of the nineteenth century and shaped early sociological thinking. This chapter suggests the centrality of these medical ideas, as mediated by Brunonianism, to the understanding of Romanticism in the nineteenth century, and argues that Brunonian ideas shaped nineteenth-century thinking about the effects of mass print culture in ways which continue to influence contemporary thinking about the effects of media.

  2. On important precursor of singular optics (tutorial)

    NASA Astrophysics Data System (ADS)

    Polyanskii, Peter V.; Felde, Christina V.; Bogatyryova, Halina V.; Konovchuk, Alexey V.

    2018-01-01

    The rise of singular optics is usually associated with the seminal paper by J. F. Nye and M. V. Berry [Proc. R. Soc. Lond. A, 336, 165-189 (1974)]. Intense development of this area of modern photonics has started since the early eighties of the XX century due to invention of the interfrence technique for detection and diagnostics of phase singularities, such as optical vortices in complex speckle-structured light fields. The next powerful incentive for formation of singular optics into separate area of the science on light was connectected with discovering of very practical technique for creation of singular optical beams of various kinds on the base of computer-generated holograms. In the eghties and ninetieth of the XX century, singular optics evolved, almost entirely, under the approximation of complete coherency of light field. Only at the threshold of the XXI century, it has been comprehended that the singular-optics approaches can be fruitfully expanded onto partially spatially coherent, partially polarized and polychromatic light fields supporting singularities of new kinds, that has been resulted in establishing of correlation singular optics. Here we show that correlation singular optics has much deeper roots, ascending to "pre-singular" and even pre-laser epoch and associated with the concept of partial coherence and polarization. It is remarcable that correlation singular optics in its present interpretation has forestalled the standard coherent singular optics. This paper is timed to the sixtieth anniversary of the most profound precursor of modern correlation singular optics [J. Opt. Soc. Am., 47, 895-902 (1957)].

  3. Educational Sciences, Morality and Politics: International Educational Congresses in the Early Twentieth Century

    ERIC Educational Resources Information Center

    Fuchs, Eckhardt

    2004-01-01

    Internationalism became one of the keywords in the international intellectual and political debates at the end of the nineteenth century. As a political, cultural and social movement it also included science and education. The desire for international cooperation and global understanding was caused by the growing economic interdependence in the…

  4. Immigration, Wealth and the ‘Mortality Plateau’ in Emergent Urban-Industrial Towns of Nineteenth-Century Massachusetts

    PubMed Central

    Beemer, Jeffrey K.; Anderton, Douglas L.

    2013-01-01

    The mortality transition in Western Europe and the U.S. encompassed a much more complex set of conditions and experiences than earlier thought. Our research addresses the complex set of relationships among growing urban communities, family wealth, immigration and mortality in New England by examining individual-level, socio-demographic mortality correlates during the nineteenth-century mortality plateau and its early twentieth-century decline. In contrast to earlier theories that proposed a more uniform mortality transition, we offer an alternative hypothesis that focuses on the impact of family wealth and immigration on individual-level mortality during the early stages of the mortality transition in Northampton and Holyoke, Massachusetts. PMID:23667286

  5. A visit to Biotopia: genre, genetics and gardening in the early twentieth century.

    PubMed

    Endersby, Jim

    2018-06-20

    The early decades of the twentieth century were marked by widespread optimism about biology and its ability to improve the world. A major catalyst for this enthusiasm was new theories about inheritance and evolution (particularly Hugo de Vries's mutation theory and Mendel's newly rediscovered ideas). In Britain and the USA particularly, an astonishingly diverse variety of writers (from elite scientists to journalists and writers of fiction) took up the task of interpreting these new biological ideas, using a wide range of genres to help their fellow citizens make sense of biology's promise. From these miscellaneous writings a new and distinctive kind of utopianism emerged - the biotopia. Biotopias offered the dream of a perfect, post-natural world, or the nightmare of violated nature (often in the same text), but above all they conveyed a sense that biology was - for the first time - offering humanity unprecedented control over life. Biotopias often visualized the world as a garden perfected for human use, but this vision was tinged with gendered violence, as it became clear that realizing it entailed dispossessing, or even killing, 'Mother Nature'. Biotopian themes are apparent in journalism, scientific reports and even textbooks, and these non-fiction sources shared many characteristics with intentionally prophetic or utopian fictions. Biotopian themes can be traced back and forth across the porous boundaries between popular and elite writing, showing how biology came to function as public culture. This analysis reveals not only how the historical significance of science is invariably determined outside the scientific world, but also that the ways in which biology was debated during this period continue to characterize today's debates over new biological breakthroughs.

  6. Controlling measurement-induced nonlocality in the Heisenberg XX model by three-spin interactions

    NASA Astrophysics Data System (ADS)

    Xie, Yu-Xia; Sun, Yu-Hang; Li, Zhao

    2018-01-01

    We investigate the well-defined measures of measurement-induced nonlocality (MIN) for thermal states of the transverse field XX model, with the addition of three-spin interaction terms being introduced. The results showed that the MINs are very sensitive to system parameters of the chain. The three-spin interactions can serve as flexible parameters for enhancing MINs of the boundary spins, and the maximum enhancement achievable by varying strengths of the three-spin interactions are different for the chain with different number of spins.

  7. Circuit Chautauqua: From Rural Education to Popular Entertainment in Early Twentieth Century America.

    ERIC Educational Resources Information Center

    Tapia, John Edward

    In 1874, Methodist minister John Vincent began a Sunday school retreat on the shores of Lake Chautauqua, New York, the mission of which was education. Initial offerings such as Bible reading, biblical geography, and public oration were supplemented with general education and entertainment activities. In the late 19th century, the Chautauqua…

  8. Collecting among the Menomini: Cultural Assault in Twentieth-Century Wisconsin

    ERIC Educational Resources Information Center

    Beck, David R. M.

    2010-01-01

    From the late nineteenth century through the early 1930s a succession of collectors, ethnologists, and other scholars scoured the Menominee Reservation for data and items of material culture, which they presented to the American public through both publication and display. They did this with the cautious aid of Menominees they hired to provide…

  9. The emergence of medical specialization in the nineteenth century.

    PubMed

    Weisz, George

    2003-01-01

    This essay reexamines the nineteenth-century origins of medical specialization. It suggests that by the 1880s, specialization had become perceived as a necessity of medical science as a result of the realization of two preconditions: First, a new collective desire to expand medical knowledge prompted clinical researchers to specialize; only specialization, it was believed, permitted the rigorous observation of many cases. Second, administrative rationality suggested that one could best manage large populations through proper classification, gathering together individuals belonging to the same class and separating those belonging to different categories. Both of these conditions emerged first and most powerfully in early nineteenth-century Paris. They were, in contrast, uniquely underdeveloped in the fragmented medical community of London during this period.

  10. The mid 19th and early 20th Century Pull of a Nearby Eclipse Shadow Path

    NASA Astrophysics Data System (ADS)

    Bonifácio, Vitor

    2012-09-01

    The unique observing conditions allowed by total solar eclipses made them a highly desirable target of 19th and early 20th century astronomical expeditions, particularly after 1842. Due to the narrowness of the lunar shadow at the Earth's surface this usually implied traveling to faraway locations with all the subsequent inconveniences, in particular, high costs and complex logistics. A situation that improved as travel became faster, cheaper and more reliable. The possibility to observe an eclipse in one's own country implied no customs, no language barriers, usually shorter travelling distances and the likely support of local and central authorities. The eclipse proximity also provided a strong argument to pressure the government to support the eclipse observation. Sometimes the scientific elite would use such high profile events to rhetorically promote broader goals. In this paper we will analyse the motivation, goals, negotiating strategies and outcomes of the Portuguese eclipse expeditions made between 1860 and 1914. We will focus, in particular, on the observation of the solar eclipses of 22 December 1870 and 17 April 1912. The former allowed the start-up of astrophysical studies in the country while the movie obtained at the latter led Francisco da Costa Lobo to unexpectedly propose a polar flattening of the Moon.

  11. Late-Eighteenth-Century Precipitation Reconstructions from James Madison's Montpelier Plantation.

    NASA Astrophysics Data System (ADS)

    Druckenbrod, Daniel L.; Mann, Michael E.; Stahle, David W.; Cleaveland, Malcolm K.; Therrell, Matthew D.; Shugart, Herman H.

    2003-01-01

    This study presents two independent reconstructions of precipitation from James Madison's Montpelier plantation at the end of the eighteenth century. The first is transcribed directly from meteorological diaries recorded by the Madison family for 17 years and reflects the scientific interests of James Madison and Thomas Jefferson. In his most active period as a scientist, Madison assisted Jefferson by observing the climate and fauna in Virginia to counter the contemporary scientific view that the humid, cold climate of the New World decreased the size and number of its species. The second reconstruction is generated using tree rings from a forest in the Montpelier plantation and connects Madison's era to the modern instrumental precipitation record. These trees provide a significant reconstruction of both early summer and prior fall precipitation. Comparison of the dendroclimatic and diary reconstructions suggests a delay in the seasonality of precipitation from Madison's era to the mid-twentieth century. Furthermore, the dendroclimatic reconstructions of early summer and prior fall precipitation appear to track this shift in seasonality.

  12. The riddle of sex: biological theories of sexual difference in the early twentieth-century.

    PubMed

    Ha, Nathan Q

    2011-01-01

    At the turn of the twentieth century, biologists such as Oscar Riddle, Thomas Hunt Morgan, Frank Lillie, and Richard Goldschmidt all puzzled over the question of sexual difference, the distinction between male and female. They all offered competing explanations for the biological cause of this difference, and engaged in a fierce debate over the primacy of their respective theories. Riddle propounded a metabolic theory of sex dating from the late-nineteenth century suggesting that metabolism lay at the heart of sexual difference. Thomas Hunt Morgan insisted on the priority of chromosomes, Frank Lillie emphasized the importance of hormones, while Richard Goldschmidt supported a mixed model involving both chromosomes and hormones. In this paper, I will illustrate how the older metabolic theory of sex was displaced when those who argued for the relatively newer theories of chromosomes and hormones gradually formed an alliance that accommodated each other and excluded the metabolic theory of sex. By doing so, proponents of chromosomes and hormones established their authority over the question of sexual difference as they laid the foundations for the new disciplines of genetics and endocrinology. Their debate raised urgent questions about what constituted sexual difference, and how scientists envisioned the plasticity and controllability of this difference. These theories also had immediate political and cultural consequences at the turn of the twentieth century, especially for the eugenic and feminist movements, both of which were heavily invested in knowledge of sex and its determination, ascertainment, and command.

  13. Science on the fringe of the empire: the Academy of the Linceans in the early nineteenth century.

    PubMed

    Donato, Maria Pia

    2012-01-01

    The article treats the Academy of the Linceans in the early nineteenth century, and more particularly during the Napoleonic domination of Rome in 1809-14. For the French regime, the Academy was instrumental to turning intellectuals into notables; pursuing the advancement of knowledge; stimulating industry; fostering secularization and orientating public opinion. But these goals did not always harmonize one with the other. Moreover, the local agenda was subordinated to strategic and ideological considerations pertaining to the organization of the Empire, relations with the Papacy, and internal politics. Hence, support to the Academy was subject to changes and contradictions. Within the Empire, the small local scientific elite found a place within international networks of science. Men of science increased their visibility and social standing, and greater symbolic and material resources were granted to the practice of science. The Academy, however, was left in the unclear status of a semi-public establishment, and it eventually imploded after the Restoration. The article analyses the Academy's scientific activity and its role in public life, focusing on material history as a key element to understand the ambiguous nature of Roman scientific institutions both under the papal government and the French regime.

  14. Making Space for Red Tide: Discolored Water and the Early Twentieth Century Bayscape of Japanese Pearl Cultivation.

    PubMed

    Ericson, Kjell

    2017-05-01

    "Red tide" has become a familiar shorthand for unusual changes in the color of ocean waters. It is intimately related both to blooms of creatures like dinoflagellates and to the devastating effects they pose to coastal fisheries. This essay tracks the early twentieth century emergence of discolored water as an aquacultural problem, known in Japan as akashio, and its trans-oceanic transformation into the terms and practices of "red tide" in the post-World War II United States. For Japan's "Pearl King" Mikimoto Kōkichi and his contacts in diverse marine scientific communities, the years-long cycle of guarding and cultivating a pearl oyster went together with the ascription of moral qualities to tiny creatures that posed a threat to farmed bayscapes of pearl monoculture. As akashio, discolored water went from curiosity to marine livestock pest, one that at times left dead pearl oysters in its wake. Red tide arose from the sustained study of the mechanisms by which changes in the biological and chemical composition of seawater might become deadly to exclusively-claimed shellfish along Japanese coastlines, but came to be seen as a way to understand aquatic manifestations of harm in other parts of the littoral world.

  15. A duplication upstream of SOX9 was not positively correlated with the SRY-negative 46,XX testicular disorder of sex development: A case report and literature review

    PubMed Central

    XIA, XIN-YI; ZHANG, CUI; LI, TIAN-FU; WU, QIU-YUE; LI, NA; LI, WEI-WEI; CUI, YING-XIA; LI, XIAO-JUN; SHI, YI-CHAO

    2015-01-01

    The 46,XX male disorder of sex development (DSD) is rarely observed in humans. Patients with DSD are all male with testicular tissue differentiation. The mechanism of sex determination and differentiation remains to be elucidated. In the present case report, an 46,XX inv (9) infertile male negative for the sex-determining region of the Y chromosome (SRY) gene was examined. This infertile male was systemically assessed by semen analysis, serum hormone testing and gonadal biopsy. Formalin-fixed and paraffin-embedded gonad tissues were assessed histochemically. The SRY gene was analyzed by fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR). The other 23 specific loci, including the azoospermia factor region on the Y chromosome and the sequence-targeted sites of the SRY-box 9 (SOX9) gene were analyzed by PCR. The genes RSPO1, DAX1, SOX3, ROCK, DMRT1, SPRY2 and FGF9 were also assessed using sequencing analysis. Affymetrix Cytogenetics Whole Genome 2.7 M Arrays were used for detecting the genomic DNA from the patient and the parents. The patient with the 46,XX inv (9) (p11q13) karyotype exhibited male primary, however, not secondary sexual characteristics. However, the patient's mother with the 46, XX inv (9) karyotype was unaffected. The testicular tissue dysplasia of the patient was confirmed by tissue biopsy and absence of the SRY gene, and the other 23 loci on the Y chromosome were confirmed by FISH and/or PCR. The RSPO1, DAX1, SOX3, ROCK, DMRT1, SPRY2 and FGF9 genes were sequenced and no mutations were detected. A duplication on the 3 M site in the upstream region of SOX9 was identified in the patient as well as in the mother. The patient with the 46,XX testicular DSD and SRY-negative status was found to be infertile. The duplication on the 3 M site in the upstream region of SOX9 was a polymorphism, which indicated that the change was not a cause of 46,XX male SDS. These clinical, molecular and cytogenetic findings suggested that other

  16. A duplication upstream of SOX9 was not positively correlated with the SRY‑negative 46,XX testicular disorder of sex development: A case report and literature review.

    PubMed

    Xia, Xin-Yi; Zhang, Cui; Li, Tian-Fu; Wu, Qiu-Yue; Li, Na; Li, Wei-Wei; Cui, Ying-Xia; Li, Xiao-Jun; Shi, Yi-Chao

    2015-10-01

    The 46,XX male disorder of sex development (DSD) is rarely observed in humans. Patients with DSD are all male with testicular tissue differentiation. The mechanism of sex determination and differentiation remains to be elucidated. In the present case report, an 46,XX inv (9) infertile male negative for the sex‑determining region of the Y chromosome (SRY) gene was examined. This infertile male was systemically assessed by semen analysis, serum hormone testing and gonadal biopsy. Formalin‑fixed and paraffin‑embedded gonad tissues were assessed histochemically. The SRY gene was analyzed by fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR). The other 23 specific loci, including the azoospermia factor region on the Y chromosome and the sequence-targeted sites of the SRY‑box 9 (SOX9) gene were analyzed by PCR. The genes RSPO1, DAX1, SOX3, ROCK, DMRT1, SPRY2 and FGF9 were also assessed using sequencing analysis. Affymetrix Cytogenetics Whole Genome 2.7 M Arrays were used for detecting the genomic DNA from the patient and the parents. The patient with the 46,XX inv (9) (p11q13) karyotype exhibited male primary, however, not secondary sexual characteristics. However, the patient's mother with the 46, XX inv (9) karyotype was unaffected. The testicular tissue dysplasia of the patient was confirmed by tissue biopsy and absence of the SRY gene, and the other 23 loci on the Y chromosome were confirmed by FISH and/or PCR. The RSPO1, DAX1, SOX3, ROCK, DMRT1, SPRY2 and FGF9 genes were sequenced and no mutations were detected. A duplication on the 3 M site in the upstream region of SOX9 was identified in the patient as well as in the mother. The patient with the 46,XX testicular DSD and SRY‑negative status was found to be infertile. The duplication on the 3 M site in the upstream region of SOX9 was a polymorphism, which indicated that the change was not a cause of 46,XX male SDS. These clinical, molecular and cytogenetic findings suggested that

  17. Duplication of SOX9 associated with 46,XX ovotesticular disorder of sex development.

    PubMed

    López-Hernández, Berenice; Méndez, Juan Pablo; Coral-Vázquez, Ramón Mauricio; Benítez-Granados, Jesús; Zenteno, Juan Carlos; Villegas-Ruiz, Vanessa; Calzada-León, Raúl; Soderlund, Daniela; Canto, Patricia

    2018-04-04

    The purpose of the present study was to investigate whether ten unrelated SRY-negative individuals with this sex differentiation disorder presented a double dose of SOX9 as the cause of their disease. Ten unrelated SRY-negative 46,XX ovotesticular disorder of sexual development (DSD) subjects were molecularly studied. Multiplex-ligation dependent probe amplification (MLPA) and quantitative real-time PCR analysis (qRT-PCR) for SOX9 were performed. The MLPA analysis demonstrated that one patient presented a heterozygous duplication of the entire SOX9 coding region (above 1.3 value of peak ratio), as well as at least a ~ 483 kb upstream duplication. Moreover, no duplication of other SOX9 probes was observed corresponding to the region between -1007 and -1500 kb upstream. A qRT-PCR analysis showed a duplication of at least -581 kb upstream and ~1.63 kb of the coding region that encompasses exon 3. The limits of the duplication were mapped approximately from ~71539762 to 72122741 of Chr17. No molecular abnormalities were found in the remaining nine patients. This study is thought to be the first report regarding a duplication of SOX9 that is associated with the presence of 46,XX ovotesticular DSD, encompassing at least -581 kb upstream, and the almost entire coding region of the gene. Copyright © 2018 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  18. Peroxide Propulsion at the Turn of the Century

    NASA Technical Reports Server (NTRS)

    Anderson, William E.; Butler, Kathy; Crocket, Dave; Lewis, Tim; McNeal, Curtis

    2000-01-01

    A resurgence of interest in peroxide propulsion has occurred in the last years of the 21st Century. This interest is driven by the need for lower cost propulsion systems and the need for storable reusable propulsion systems to meet future space transportation system architectures. NASA and the Air Force are jointly developing two propulsion systems for flight demonstration early in the 21st Century. One system will be a development of Boeing's AR2-3 engine, which was successfully fielded in the 1960s. The other is a new pressure-fed design by Orbital Sciences Corporation for expendable mission requirements. Concurrently NASA and industry are pursuing the key peroxide technologies needed to design, fabricate, and test advanced peroxide engines to meet the mission needs beyond 2005. This paper will present a description of the AR2-3, report the status of its current test program, and describe its intended flight demonstration. This paper will then describe the Orbital 10K engine, the status of its test program, and describe its planned flight demonstration. Finally the paper will present a plan, or technology roadmap, for the development of an advanced peroxide engine for the 21st Century.

  19. African Girls, Nineteenth-Century Mission Education and the Patriarchal Imperative

    ERIC Educational Resources Information Center

    Leach, Fiona

    2008-01-01

    This paper draws on Anglican mission archive material to uncover the extent to which girls' schooling in early nineteenth-century West Africa developed as a response to male interests and perceived male needs. The founding of the colony of Sierra Leone in 1787 as a home for freed slaves followed by the arrival of Protestant missionaries in 1804…

  20. Embedding the New Science of Research: The Organised Culture of Scottish Educational Research in the Mid-Twentieth Century

    ERIC Educational Resources Information Center

    Lawn, Martin; Deary, Ian J.; Bartholomew, David J.; Brett, Caroline

    2010-01-01

    Educational research was established in the early decades of the twentieth century in many parts of Europe. The early years were the crucial years as they established dominant forms of inquiry, pioneer sites, and related artefacts, the tools and texts. This paper focuses on the early growth of research culture in education in Scotland, its…

  1. Twenty-first century learning after school: the case of 4-H.

    PubMed

    Kress, Cathann

    2006-01-01

    Founded in the early 1900s, the 4-H Youth Development program can serve as a model for out-of-school programs of the twenty-first century. The 4-H pledge, repeated by its members--over 7 million, ranging in age from five to twenty--articulates its core values: "I pledge: My head to clearer thinking, My heart to greater loyalty, My hands to larger service, and My health to better living for my club, my community, my country, and my world." The 4-H Development movement was created to provide opportunities for rural children, to help them become constructive adults. Through an emphasis on "learning by doing," 4-H teaches children the habits of lifelong learning. Historically, 4-H has tapped into university-level advancements, extending such knowledge to youth and thereby giving them early access to scientific discoveries and technological progress. Members apply this learning in their communities through hands-on projects crossing a wide-range of pertinent topics. Research shows that 4-H members are more successful in school than other children and develop a wide range of skills essential in the twenty-first century. Thus, the author makes the case that the foundation of 4-H is exceptionally relevant in today's complex world, perhaps even more so than a century ago. 4-H is a leader in youth development, making it a natural model for twenty-first century after-school programs. Expanding on the 4-H pledge, the author outlines the principles a successful youth development program would have: an emphasis on leadership skills, a feeling of connection and belonging, a forum for exploring career opportunities, and a component of meaningful community service.

  2. [Alfredo Tramoyeres Cases (1910-2002): first chairman of the Department of Urology at the Ciudad Sanitaria La Fe. Documentary-historical analysis of his works].

    PubMed

    Cánovas Ivorra, José Antonio; Tramoyeres Galvañ, Alfredo; Sánchez Ballester, Francisco; De la Torre Abril, Luis; Ordoño Domínguez, Felipe; Navalón Verdejo, Pedro; Pérez Albacete, Mariano; López Alcina, Emilio; Zaragoza Orts, Julio

    2004-12-01

    Urology, having been part of general surgery for centuries, was completely consolidated as a medical speciality in the middle of the XX Century as the result of years of evolution and development, and all the studies and works of certain authors that represent today the mainstays of our speciality. Valencia in the middle of the 20th century saw the birth of new hospitals including the "Ciudad Sanitaria La Fe". Alfredo Tramoyeres Cases was the first chairman of the Department of Urology. This article reviews his long and fertile professional life. We have reviewed all his scientific works. The articles have been obtained from Medicina Española, Revista Española de Cirugía Traumatológica y Ortopedia, and Archivos Españoles de Urología. His most important urological work is his doctoral thesis with the title "Sigmoid-procto-ureterostomy: personal modification" published in Valencia in 1976. For his biography we used the" Biographic and bibliographic history of the Spanish Urology over the XX century" and interviews with family members. We emphasize his thorough description of the various types of urinary diversion. He covers the topics of bladder diverticula and bladder neck disorders, in which he supports surgical treatment. Finally, he sets out the rupture of the posterior urethra and various treatments for prostate cancer at that time. Alfredo Tramoyeres Cases contributed to the definitive consolidation of our speciality in the area of Valencia during the second half of the XX century, through his long professional life, with his interesting scientific contributions.

  3. High resolution X-ray spectra of solar flares. V - Interpretation of inner-shell transitions in Fe XX-Fe XXIII

    NASA Technical Reports Server (NTRS)

    Doschek, G. A.; Feldman, U.; Cowan, R. D.

    1981-01-01

    The paper examines high-resolution solar flare iron line spectra recorded between 1.82 and 1.97 A by a spectrometer flown by the Naval Research Laboratory on an Air Force spacecraft launched on 1979 February 24. The emission line spectrum is due to inner-shell transitions in the ions Fe XX-Fe XXV. Using theoretical spectra and calculations of line intensities obtained by methods discussed by Merts, Cowan, and Magee (1976), electron temperatures as a function of time for two large class X flares are derived. These temperatures are deduced from intensities of lines of Fe XXII, Fe XXIII, and Fe XXIV. The determination of the differential emission measure between about 12-million and 20-million K using these temperatures is considered. The possibility of determining electron densities in flare and tokamak plasmas using the inner-shell spectra of Fe XXI and Fe XX is discussed.

  4. Reconstructing Early Industrial Contributions to Legacy Trace Metal Contamination in Southwestern Pennsylvania.

    PubMed

    Rossi, Robert J; Bain, Daniel J; Hillman, Aubrey L; Pompeani, David P; Finkenbinder, Matthew S; Abbott, Mark B

    2017-04-18

    Early industrial trace metal loadings are poorly characterized but potentially substantial sources of trace metals to the landscape. The magnitude of legacy contamination in southwestern Pennsylvania, the cradle of North American fossil fuel industrialization, is reconstructed from trace metal concentrations in a sediment core with proxies including major and trace metal chemistry, bulk density, and magnetic susceptibility. Trace metal chemistry in this sediment record reflects 19th and 20th century land use and industry. In particular, early 19th century arsenic loadings to the lake are elevated from pesticides used by early European settlers at a lakeside tannery. Later, sediment barium concentrations rise, likely reflecting the onset of acidic mine drainage from coal operations. Twentieth century zinc, cadmium, and lead concentrations are dominated by emissions from the nearby, infamous Donora Zinc Works yet record both the opening of a nearby coal-fired power plant and amendments to the Clean Air Act. The impact of early industry is substantial and rivals more recent metal fluxes, resulting in a significant potential source of contaminated sediments. Thus, modern assessments of trace metal contamination cannot ignore early industrial inputs, as the potential remobilization of legacy contamination would impact ecosystem and human health.

  5. Revolution and Education in Late Nineteenth Century France: The Early Career of Paul Robin.

    ERIC Educational Resources Information Center

    Mclaren, Angus

    1981-01-01

    Discusses the importance of the work of radical educator Paul Robin and the socio-political environment in nineteenth century France which prompted it. Robin advocated free, secular, public education for the working classes which stressed spontaneity, practicality, individualized instruction, and sexual equality. (AM)

  6. Relative dosimetrical verification in high dose rate brachytherapy using two-dimensional detector array IMatriXX

    PubMed Central

    Manikandan, A.; Biplab, Sarkar; David, Perianayagam A.; Holla, R.; Vivek, T. R.; Sujatha, N.

    2011-01-01

    For high dose rate (HDR) brachytherapy, independent treatment verification is needed to ensure that the treatment is performed as per prescription. This study demonstrates dosimetric quality assurance of the HDR brachytherapy using a commercially available two-dimensional ion chamber array called IMatriXX, which has a detector separation of 0.7619 cm. The reference isodose length, step size, and source dwell positional accuracy were verified. A total of 24 dwell positions, which were verified for positional accuracy gave a total error (systematic and random) of –0.45 mm, with a standard deviation of 1.01 mm and maximum error of 1.8 mm. Using a step size of 5 mm, reference isodose length (the length of 100% isodose line) was verified for single and multiple catheters of same and different source loadings. An error ≤1 mm was measured in 57% of tests analyzed. Step size verification for 2, 3, 4, and 5 cm was performed and 70% of the step size errors were below 1 mm, with maximum of 1.2 mm. The step size ≤1 cm could not be verified by the IMatriXX as it could not resolve the peaks in dose profile. PMID:21897562

  7. "Doing" Social Justice in Early Childhood: The Potential of Leadership

    ERIC Educational Resources Information Center

    Hard, Louise; Press, Frances; Gibson, Megan

    2013-01-01

    Early childhood education has long been connected with objectives related to social justice. Australian early childhood education and care (ECEC) has its roots in philanthropic and educational reform movements prevalent at the turn of the twentieth century. More recently, with the introduction of the National Early Childhood Reform Agenda, early…

  8. FAST20XX: Achievements On European Suborbital Space Flight

    NASA Astrophysics Data System (ADS)

    Mack, A.; Steelant, J.; Adirim, H.; Lentsch, A.; Marini, M.; Pilz, N.

    2011-05-01

    In Europe, the EC co-funded project FAST20XX aims at exploring the borderline between aviation and space by investigating suborbital vehicles. The main focus is the identification and mastering of critical technologies for such vehicles rather than the vehicle development itself. Besides the objectives and overall layout of the project, the paper addresses also the progress made during the first period of the project. Two vehicle concepts are considered. A first one is a space vehicle launched from an airplane providing a low-energy ballistic flight experience using hybrid propulsion. The second is a vertically starting two-stage rocket space vehicle system concept taken as a basis to identify the conditions and constraints experienced during high- energy suborbital ultra-fast transport. The paper mainly discusses the two actual reference vehicles and the technical aspects of prerequisites for commercial operation including safety, human spaceflight, business cases, environmental and legal issues.

  9. Improved Rainfall Estimates and Predictions for 21st Century Drought Early Warning

    NASA Technical Reports Server (NTRS)

    Funk, Chris; Peterson, Pete; Shukla, Shraddhanand; Husak, Gregory; Landsfeld, Marty; Hoell, Andrew; Pedreros, Diego; Roberts, J. B.; Robertson, F. R.; Tadesse, Tsegae; hide

    2015-01-01

    As temperatures increase, the onset and severity of droughts is likely to become more intense. Improved tools for understanding, monitoring and predicting droughts will be a key component of 21st century climate adaption. The best drought monitoring systems will bring together accurate precipitation estimates with skillful climate and weather forecasts. Such systems combine the predictive power inherent in the current land surface state with the predictive power inherent in low frequency ocean-atmosphere dynamics. To this end, researchers at the Climate Hazards Group (CHG), in collaboration with partners at the USGS and NASA, have developed i) a long (1981-present) quasi-global (50degS-50degN, 180degW-180degE) high resolution (0.05deg) homogenous precipitation data set designed specifically for drought monitoring, ii) tools for understanding and predicting East African boreal spring droughts, and iii) an integrated land surface modeling (LSM) system that combines rainfall observations and predictions to provide effective drought early warning. This talk briefly describes these three components. Component 1: CHIRPS The Climate Hazards group InfraRed Precipitation with Stations (CHIRPS), blends station data with geostationary satellite observations to provide global near real time daily, pentadal and monthly precipitation estimates. We describe the CHIRPS algorithm and compare CHIRPS and other estimates to validation data. The CHIRPS is shown to have high correlation, low systematic errors (bias) and low mean absolute errors. Component 2: Hybrid statistical-dynamic forecast strategies East African droughts have increased in frequency, but become more predictable as Indo- Pacific SST gradients and Walker circulation disruptions intensify. We describe hybrid statistical-dynamic forecast strategies that are far superior to the raw output of coupled forecast models. These forecasts can be translated into probabilities that can be used to generate bootstrapped ensembles

  10. The Early Days of Polymer Science

    ERIC Educational Resources Information Center

    Mark, H.

    1973-01-01

    Summarizes research studies made early in this century in the fields of cellulose, starch, proteins, and rubber. Included is a description of factors which give rise to the concept of very long, chain-like molecules. (CC)

  11. Religion or Citizenship? Beyond the Binary; Lessons after a Century of Disagreement

    ERIC Educational Resources Information Center

    Caride, Ezequiel Gomez

    2018-01-01

    This article describes how different approaches to religion (institutional and cultural) lead to startlingly different conclusions when analyzing how religion shapes the republican citizen. Through a genealogical discourse analysis, I examine educational reports issued by Argentinean authorities in the early twentieth century that made the Jew out…

  12. If All the World Were Chicago: American Education in the Twentieth Century.

    ERIC Educational Resources Information Center

    Lazerson, Marvin

    1984-01-01

    Four sets of issues as they relate to the city of Chicago during the late 19th and early 20th centuries are examined: race and the liberal agenda, the role of academics in public policy, the organization of teachers, and the ambiguities of progressive policy. (RM)

  13. The emergence of Nervennahrung: Nerves, mind and metabolism in the long eighteenth century.

    PubMed

    Stahnisch, Frank W

    2012-06-01

    Morphological assumptions concerning the form, structure and internal life of the brain and nervous system profoundly influenced contemporary physiological concepts about nerve actions throughout the 'long eighteenth century'. This article investigates some early theories of mind and metabolism. In a bottom-up fashion, it asks how eighteenth-century theories regarding the physiological actions of the body organs shaped the conceptions of the structure of the brain and nervous tissue themselves. These proposed that a healthy Nervennahrung (the German word for 'nerve nutrition', which might be rendered as brain food in modern English), not only guaranteed the integrity and stability of neuronal structures in the body, but also explained the complex texture of the brain and spinal cord in physiological terms. Eighteenth-century nerve theories already embodied a Leitmotiv of neurology and brain psychiatry from the later nineteenth century: 'Without phosphorus there is no thought!' Copyright © 2011 Elsevier Ltd. All rights reserved.

  14. Soul sisters: the St. John and Raynard nurses in nineteenth century London.

    PubMed

    Williamson, L

    1996-01-01

    This paper uses the archives of the St John's training institution for nurses and the Raynard Mission to determine the extent to which cultural images and specialised space defined and drove the nursing profession in nineteenth and early twentieth century London. Emphasis is placed upon image and rhetoric, both sacred and secular, and the way the two combined to define the 'ideal' Victorian woman and nursing in the nineteenth and early twentieth centuries, and the understanding and treatment of illness. Research to date suggests that through a process of rationalisation of biblical and socio-cultural rhetoric, a specialisation of space, symbolic and literal, abstract and real was created; this enabled women to work in a gendered enclave, the organisational structure and rhetoric of which paralleled that of nunneries or convents. And even as the 'secular' became dominant in medical attitudes and treatment, the 'sacred'aspect of nursing and the emphasis placed upon it as being a vocation remained strong.

  15. Copy number variation of two separate regulatory regions upstream of SOX9 causes isolated 46,XY or 46,XX disorder of sex development.

    PubMed

    Kim, Gwang-Jin; Sock, Elisabeth; Buchberger, Astrid; Just, Walter; Denzer, Friederike; Hoepffner, Wolfgang; German, James; Cole, Trevor; Mann, Jillian; Seguin, John H; Zipf, William; Costigan, Colm; Schmiady, Hardi; Rostásy, Moritz; Kramer, Mildred; Kaltenbach, Simon; Rösler, Bernd; Georg, Ina; Troppmann, Elke; Teichmann, Anne-Christin; Salfelder, Anika; Widholz, Sebastian A; Wieacker, Peter; Hiort, Olaf; Camerino, Giovanna; Radi, Orietta; Wegner, Michael; Arnold, Hans-Henning; Scherer, Gerd

    2015-04-01

    SOX9 mutations cause the skeletal malformation syndrome campomelic dysplasia in combination with XY sex reversal. Studies in mice indicate that SOX9 acts as a testis-inducing transcription factor downstream of SRY, triggering Sertoli cell and testis differentiation. An SRY-dependent testis-specific enhancer for Sox9 has been identified only in mice. A previous study has implicated copy number variations (CNVs) of a 78 kb region 517-595 kb upstream of SOX9 in the aetiology of both 46,XY and 46,XX disorders of sex development (DSD). We wanted to better define this region for both disorders. By CNV analysis, we identified SOX9 upstream duplications in three cases of SRY-negative 46,XX DSD, which together with previously reported duplications define a 68 kb region, 516-584 kb upstream of SOX9, designated XXSR (XX sex reversal region). More importantly, we identified heterozygous deletions in four families with SRY-positive 46,XY DSD without skeletal phenotype, which define a 32.5 kb interval 607.1-639.6 kb upstream of SOX9, designated XY sex reversal region (XYSR). To localise the suspected testis-specific enhancer, XYSR subfragments were tested in cell transfection and transgenic experiments. While transgenic experiments remained inconclusive, a 1.9 kb SRY-responsive subfragment drove expression specifically in Sertoli-like cells. Our results indicate that isolated 46,XY and 46,XX DSD can be assigned to two separate regulatory regions, XYSR and XXSR, far upstream of SOX9. The 1.9 kb SRY-responsive subfragment from the XYSR might constitute the core of the Sertoli-cell enhancer of human SOX9, representing the so far missing link in the genetic cascade of male sex determination. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  16. 46,XX testicular disorder of sexual development with SRY-negative caused by some unidentified mechanisms: a case report and review of the literature.

    PubMed

    Li, Tian-Fu; Wu, Qiu-Yue; Zhang, Cui; Li, Wei-Wei; Zhou, Qing; Jiang, Wei-Jun; Cui, Ying-Xia; Xia, Xin-Yi; Shi, Yi-Chao

    2014-12-22

    46,XX testicular disorder of sex development is a rare genetic syndrome, characterized by a complete or partial mismatch between genetic sex and phenotypic sex, which results in infertility because of the absence of the azoospermia factor region in the long arm of Y chromosome. We report a case of a 14-year-old male with microorchidism and mild bilateral gynecomastia who referred to our hospital because of abnormal gender characteristics. The patient was treated for congenital scrotal type hypospadias at the age of 4 years. Semen analysis indicated azoospermia by centrifugation of ejaculate. Levels of follicle-stimulating hormone and luteinizing hormone were elevated, while that of testosterone was low and those of estradiol and prolactin were normal. The results of gonadal biopsy showed hyalinization of the seminiferous tubules, but there was no evidence of spermatogenic cells. Karyotype analysis of the patient confirmed 46,XX karyotype and fluorescent in situ hybridization analysis of the sex-determining region Y (SRY) gene was negative. Molecular analysis revealed that the SRY gene and the AZFa, AZFb and AZFc regions were absent. No mutation was detected in the coding region and exon/intron boundaries of the RSPO1, DAX1, SOX9, SOX3, SOX10, ROCK1, and DMRT genes, and no copy number variation in the whole genome sequence was found. This study adds a new case of SRY-negative 46,XX testicular disorder of sex development and further verifies the view that the absence of major regions from the Y chromosome leads to an incomplete masculine phenotype, abnormal hormone levels and infertility. To date, the mechanisms for induction of testicular tissue in 46,XX SRY-negative patients remain unknown, although other genetic or environmental factors play a significant role in the regulation of sex determination and differentiation.

  17. Innovative Features of Comparative-Historical Research of European and Azerbaijani Cultural Heritage (Based on the Materials of British and Azerbaijani Literature of the XX Century)

    ERIC Educational Resources Information Center

    Eugster, Nicolas; Hasanov, Elnur L.

    2016-01-01

    The beginning of the twentieth century is characterized as a period of formation of literary prose in Azerbaijan literature, which reminds already formed a new type of British prose. These new development trends appeared in plot, content, style, the world of characters, artistic-philosophical thought as well as in narrative features. The genre of…

  18. Early 21st century spatially detailed elevation changes of Jammu and Kashmir glaciers (Karakoram-Himalaya)

    NASA Astrophysics Data System (ADS)

    Vijay, Saurabh; Braun, Matthias

    2018-06-01

    Although a number of studies indicate the regional heterogeneity of the glacier elevation and mass changes in high-mountain Asia in the early 21st century, little is known about these changes with high spatial detail for some of the regions. In this study we present respective glacier elevation and mass change estimates in the Indian state of Jammu and Kashmir (JK) for the period 2000-2012. Our estimates are based on the interferometric analysis of SRTM DEM and the bistatic TanDEM-X data. On an average the JK East (Karakoram) glaciers showed less negative elevation changes (- 0.19 ± 0.22 m yr-1) compared to the JK West (Himalaya) glaciers (- 0.50 ± 0.28 m yr-1). This agrees very well with previous studies that show a transition from larger changes in the western Himalaya to a steady-state situation in the Karakoram. We observe distinct elevation change patterns on a glacier scale that is most likely linked to debris insulation and the enhanced ice melting due to supraglacial lakes, ponds and ice cliffs. We also found 16 surge-type glaciers in the JK East which were not documented before. In total, 25 glaciers surged and 4 others appeared to be in a quiescent phase in the observation period. Our results also reveal that the glacier-averaged elevation change rates of surge-type and non surge-type glaciers in the JK East region are not significantly different.

  19. NIH research funding and early career physician scientists: continuing challenges in the 21st century

    PubMed Central

    Garrison, Howard H.; Deschamps, Anne M.

    2014-01-01

    Physician scientists (researchers with either M.D. or M.D.-Ph.D. degrees) have the unique potential to combine clinical perspectives with scientific insight, and their participation in biomedical research has long been an important topic for policymakers and educators. Given the recent changes in the research environment, an update and extension of earlier studies of this population was needed. Our findings show that physician scientists are less likely to take a major role in biomedical research than they were in the past. The number of physician scientists receiving postdoctoral research training and career development awards is at an all-time low. Physician scientists today, on average, receive their first major research award (R01 equivalent) at a later age than in the 1980s. The number of first-time R01-equivalent awards to physicians is at the same level as it was 30 yr ago, but physicians now represent a smaller percentage of the grant recipients. The long-term decline in the number of physicians entering research careers was temporarily halted during the period of substantial U.S. National Institutes of Health (NIH) budget growth (1998–2003). These gains are lost, however, in the subsequent years when NIH budgets failed to keep pace with rising costs.— Garrison, H. H., Deschamps, A. M. NIH research funding and early career physician scientists: continuing challenges in the 21st century. PMID:24297696

  20. Inverse participation ratios in the XX spin chain

    NASA Astrophysics Data System (ADS)

    Tsukerman, Emmanuel

    2017-03-01

    We continue the study of the inverse participation ratios (IPRs) of the XXZ Heisenberg spin chain initiated by Stéphan, Furukawa, Misguich, and Pasquier (2009) and continued by Misguich, Pasquier, and Luck (2016) by focusing on the case of the XX Heisenberg spin chain. For the ground state, Stéphan et al. note that calculating the IPR is equivalent to Dyson's constant term ex-conjecture. We express the IPRs of excited states as an apparently new "discrete" Hall inner product. We analyze this inner product using the theory of symmetric functions (Jack polynomials, Schur polynomials, the standard Hall inner product, and ωq ,t) to determine some exact expressions and asymptotics for IPRs. We show that IPRs can be indexed by partitions, and asymptotically the IPR of a partition is equal to that of the conjugate partition. We relate the IPRs to two other models from physics, namely, the circular symplectic ensemble of Dyson and the Dyson-Gaudin two-dimensional Coulomb lattice gas. Finally, we provide a description of the IPRs in terms of a signed count of diagonals of permutohedra.