Event visualisation in ALICE - current status and strategy for Run 3

NASA Astrophysics Data System (ADS)

Niedziela, Jeremi; von Haller, Barthélémy

2017-10-01

A Large Ion Collider Experiment (ALICE) is one of the four big experiments running at the Large Hadron Collider (LHC), which focuses on the study of the Quark-Gluon Plasma (QGP) being produced in heavy-ion collisions. The ALICE Event Visualisation Environment (AliEve) is a tool providing an interactive 3D model of the detector’s geometry and a graphical representation of the data. Together with the online reconstruction module, it provides important quality monitoring of the recorded data. As a consequence it has been used in the ALICE Run Control Centre during all stages of Run 2. Static screenshots from the online visualisation are published on the public website - ALICE LIVE. Dedicated converters have been developed to provide geometry and data for external projects. An example of such project is the Total Event Display (TEV) - a visualisation tool recently developed by the CERN Media Lab based on the Unity game engine. It can be easily deployed on any platform, including web and mobile platforms. Another external project is More Than ALICE - an augmented reality application for visitors, overlaying detector descriptions and event visualisations on the camera’s picture. For the future Run 3 both AliEve and TEV will be adapted to fit the ALICE O2 project. Several changes are required due to the new data formats, especially so-called Compressed Time Frames.

Effects of mild running on substantia nigra during early neurodegeneration.

PubMed

Almeida, Michael F; Silva, Carolliny M; Chaves, Rodrigo S; Lima, Nathan C R; Almeida, Renato S; Melo, Karla P; Demasi, Marilene; Fernandes, Tiago; Oliveira, Edilamar M; Netto, Luis E S; Cardoso, Sandra M; Ferrari, Merari F R

2018-06-01

Moderate physical exercise acts at molecular and behavioural levels, such as interfering in neuroplasticity, cell death, neurogenesis, cognition and motor functions. Therefore, the aim of this study is to analyse the cellular effects of moderate treadmill running upon substantia nigra during early neurodegeneration. Aged male Lewis rats (9-month-old) were exposed to rotenone 1mg/kg/day (8 weeks) and 6 weeks of moderate treadmill running, beginning 4 weeks after rotenone exposure. Substantia nigra was extracted and submitted to proteasome and antioxidant enzymes activities, hydrogen peroxide levels and Western blot to evaluate tyrosine hydroxylase (TH), alpha-synuclein, Tom-20, PINK1, TrkB, SLP1, CRMP-2, Rab-27b, LC3II and Beclin-1 level. It was demonstrated that moderate treadmill running, practiced during early neurodegeneration, prevented the increase of alpha-synuclein and maintained the levels of TH unaltered in substantia nigra of aged rats. Physical exercise also stimulated autophagy and prevented impairment of mitophagy, but decreased proteasome activity in rotenone-exposed aged rats. Physical activity also prevented H 2 O 2 increase during early neurodegeneration, although the involved mechanism remains to be elucidated. TrkB levels and its anterograde trafficking seem not to be influenced by moderate treadmill running. In conclusion, moderate physical training could prevent early neurodegeneration in substantia nigra through the improvement of autophagy and mitophagy.

Attentional and affective biases for attractive females emerge early in development.

PubMed

Rennels, Jennifer Lynn; Verba, Stephanie Ann

2017-01-01

Predominant experience with females early in development results in infants developing an attractive, female-like facial representation that guides children's attention toward and affective preferences for attractive females. When combined with increased interest in the other sex at puberty, these early emerging biases might help explain the robust prosocial and financial biases men exhibit toward attractive women during adulthood.

Attention bias in earthquake-exposed survivors: an event-related potential study.

PubMed

Zhang, Yan; Kong, Fanchang; Han, Li; Najam Ul Hasan, Abbasi; Chen, Hong

2014-12-01

The Chinese Wenchuan earthquake, which happened on the 28th of May in 2008, may leave deep invisible scars in individuals. China has a large number of children and adolescents, who tend to be most vulnerable because they are in an early stage of human development and possible post-traumatic psychological distress may have a life-long consequence. Trauma survivors without post-traumatic stress disorder (PTSD) have received little attention in previous studies, especially in event-related potential (ERP) studies. We compared the attention bias to threat stimuli between the earthquake-exposed group and the control group in a masked version of the dot probe task. The target probe presented at the same space location consistent with earthquake-related words was the congruent trial, while in the space location of neutral words was the incongruent trial. Thirteen earthquake-exposed middle school students without PTSD and 13 matched controls were included in this investigation. The earthquake-exposed group showed significantly faster RTs to congruent trials than to incongruent trials. The earthquake-exposed group produced significantly shorter C1 and P1 latencies and larger C1, P1 and P2 amplitudes than the control group. In particular, enhanced P1 amplitude to threat stimuli was observed in the earthquake-exposed group. These findings are in agreement with the prediction that earthquake-exposed survivors have an attention bias to threat stimuli. The traumatic event had a much greater effect on earthquake-exposed survivors even if they showed no PTSD symptoms than individuals in the controls. These results will provide neurobiological evidences for effective intervention and prevention to post-traumatic mental problems. Copyright © 2014 Elsevier B.V. All rights reserved.

Prevalence in running events and running performance of endurance runners following a vegetarian or vegan diet compared to non-vegetarian endurance runners: the NURMI Study.

PubMed

Wirnitzer, Katharina; Seyfart, Tom; Leitzmann, Claus; Keller, Markus; Wirnitzer, Gerold; Lechleitner, Christoph; Rüst, Christoph Alexander; Rosemann, Thomas; Knechtle, Beat

2016-01-01

Beneficial and detrimental effects of various vegetarian and vegan diets on the health status are well known. Considering the growing background numbers of vegetarians and vegans, the number of vegetarian and vegan runners is likely to rise, too. Therefore, the Nutrition and Running High Mileage (NURMI) Study was designed as a comparative study to investigate the prevalence of omnivores, vegetarians, and vegans in running events and to detect potential differences in running performance comparing these three subgroups. The NURMI Study will be conducted in three steps following a cross-sectional design. Step 1 will determine epidemiological aspects of endurance runners (any distance) using a short standardized questionnaire. Step 2 will investigate dietary habits and running history from eligible participants (capable of running a half-marathon at least) using an extended standardized questionnaire. Step 3 will collect data after a running event on finishing time and final ranking as well as a post-race rating of perceived exertion, mood status, nutrient and fluid intake during the race. Our study will provide a major contribution to overcome the lack of data on the prevalence and running performance of vegetarian and vegan runners in endurance running events. We estimate the prevalence of vegetarians and vegans participating in a running event to be less compared to the respective proportion of vegetarians and vegans to the general population. Furthermore we will validate the subject's self-assessment of their respective diet. This comparative study may identify possible effects of dietary behavior on running performance und may detect possible differences between the respective subgroups: omnivorous, vegetarian and vegan runners. Trial registration Current controlled trials, ISRCTN73074080.

The Impact of Early Design Phase Risk Identification Biases on Space System Project Performance

NASA Technical Reports Server (NTRS)

Reeves, John D., Jr.; Eveleigh, Tim; Holzer, Thomas; Sarkani, Shahryar

2012-01-01

Risk identification during the early design phases of complex systems is commonly implemented but often fails to result in the identification of events and circumstances that truly challenge project performance. Inefficiencies in cost and schedule estimation are usually held accountable for cost and schedule overruns, but the true root cause is often the realization of programmatic risks. A deeper understanding of frequent risk identification trends and biases pervasive during space system design and development is needed, for it would lead to improved execution of existing identification processes and methods.

Social identity-based motivation modulates attention bias toward negative information: an event-related brain potential study

PubMed Central

Montalan, Benoît; Boitout, Alexis; Veujoz, Mathieu; Leleu, Arnaud; Germain, Raymonde; Personnaz, Bernard; Lalonde, Robert; Rebaï, Mohamed

2011-01-01

Research has demonstrated that people readily pay more attention to negative than to positive and/or neutral stimuli. However, evidence from recent studies indicated that such an attention bias to negative information is not obligatory but sensitive to various factors. Two experiments using intergroup evaluative tasks (Study 1: a gender-related groups evaluative task and Study 2: a minimal-related groups evaluative task) was conducted to determine whether motivation to strive for a positive social identity – a part of one’s self-concept – drives attention toward affective stimuli. Using the P1 component of event-related brain potentials (ERPs) as a neural index of attention, we confirmed that attention bias toward negative stimuli is not mandatory but it can depend on a motivational focus on affective outcomes. Results showed that social identity-based motivation is likely to bias attention toward affectively incongruent information. Thereby, early onset processes – reflected by the P1 component – appeared susceptible to top-down attentional influences induced by the individual’s motivation to strive for a positive social identity. PMID:24693339

Early traumatic events in psychopaths.

PubMed

Borja, Karina; Ostrosky, Feggy

2013-07-01

The relationship between diverse early traumatic events and psychopathy was studied in 194 male inmates. Criminal history transcripts were revised, and clinical interviews were conducted to determine the level of psychopathy using the Psychopathy Checklist-Revised (PCL-R) Form, and the Early Trauma Inventory was applied to assess the incidence of abuse before 18 years of age. Psychopathic inmates presented a higher victimization level and were more exposed to certain types of intended abuse than sociopathic inmates, while the sum of events and emotional abuse were associated with the PCL-R score. Our studies support the influence of early adverse events in the development of psychopathic offenders. © 2013 American Academy of Forensic Sciences.

The Unexpected Long-Run Impact of the Minimum Wage: An Educational Cascade. NBER Working Paper No. 16355

ERIC Educational Resources Information Center

Sutch, Richard

2010-01-01

Neglected, but significant, the long-run consequence of the minimum wage--which was made national policy in the United States in 1938--is its stimulation of capital deepening. This took two forms. First, the engineered shortage of low-skill, low-paying jobs induced teenagers to invest in additional human capital--primarily by extending their…

Assessing Intellectual Ability with a Minimum of Cultural Bias for Two Samples of Metis and Indian Children.

ERIC Educational Resources Information Center

West, Lloyd Wilbert

An investigation was designed to ascertain the effects of cultural background on selected intelligence tests and to identify instruments which validly measure intellectual ability with a minimum of cultural bias. A battery of tests, selected for factor analytic study, was administered and replicated at four grade levels to a sample of Metis and…

Cortisol and Alpha-amylase changes during an Ultra-Running Event.

PubMed

Deneen, Whitney P; Jones, Alexis B

2017-01-01

Elevated stress hormone concentrations can positively affect an athlete's overall performance during a competition, and in many cases, are necessary to be able to perform exercise. During extreme exercise, the body's ability to utilize energy efficiently can affect an athlete's performance. Elevated hormonal concentrations can have many benefits in regards to an athlete's overall performance during a competition. The purpose of this study was to examine the effects of long distance running, such as seen during an ultra-running event (distances beyond 26.2 miles), on the activity of the hypothalamic-pituitary-adrenocortical (HPA) axis production of cortisol (CORT) as compared to autonomic nervous system production of salivary alpha-amylase (AA). Despite the well-known effects of exercise on CORT and AA response, it is unclear what effect running beyond the marathon distance has on these levels. This study investigates what effect long duration cardio exercise, such as running up to 100K (kilometers) distance, has on the neuroendocrine system, by means of saliva samples provided by participants signed up for an ultra-marathon event. The findings of this study show that the autonomic nervous system may present a response signal during physical stress that is independent of the HPA axis response. At distances beyond the marathon length, the production of CORT and AA was found to be suppressed for athletes, which could help them in their continued performance. Furthermore, this study recognizes a difference in the overall male and female response to stress in regards to CORT and AA production.

What is the contribution of different cognitive biases and stressful childhood events to the presence and number of previous depressive episodes?

PubMed

Vrijsen, Janna N; Becker, Eni S; Arias-Vásquez, Alejandro; van Dijk, Maarten K; Speckens, Anne; Oostrom, Iris van

2014-07-30

Negative cognitive biases as well as stressful childhood events are well-known risk factors for depression. Few studies have compared the association of different types of biases and events with depression. The current study examined whether different cognitive biases and stressful childhood events variables were associated with depression and recurrence. Three types of childhood events were assessed in 83 never-depressed and 337 formerly depressed individuals: trauma within the family, trauma outside the family, and adverse events. Furthermore, after a sad mood induction procedure, participants executed a Dot Probe task (selective attentional bias), an Emotional Stroop task (attentional interference bias) and an incidental learning task (memory bias). The association of these measures with case status and recurrence status (one or multiple past episodes) was examined. Negative memory bias and traumatic childhood events within the family were associated with case status, whereas none of the bias measures or childhood events variables were associated with recurrence status. The results indicate that memory bias as well as the experience of aggression and/or abuse within the family during childhood are independently associated with depression. Biases and stressful childhood events did not offer differentiation between individuals with one or multiple past episodes. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Magnetic Nanoparticle Thermometer: An Investigation of Minimum Error Transmission Path and AC Bias Error

PubMed Central

Du, Zhongzhou; Su, Rijian; Liu, Wenzhong; Huang, Zhixing

2015-01-01

The signal transmission module of a magnetic nanoparticle thermometer (MNPT) was established in this study to analyze the error sources introduced during the signal flow in the hardware system. The underlying error sources that significantly affected the precision of the MNPT were determined through mathematical modeling and simulation. A transfer module path with the minimum error in the hardware system was then proposed through the analysis of the variations of the system error caused by the significant error sources when the signal flew through the signal transmission module. In addition, a system parameter, named the signal-to-AC bias ratio (i.e., the ratio between the signal and AC bias), was identified as a direct determinant of the precision of the measured temperature. The temperature error was below 0.1 K when the signal-to-AC bias ratio was higher than 80 dB, and other system errors were not considered. The temperature error was below 0.1 K in the experiments with a commercial magnetic fluid (Sample SOR-10, Ocean Nanotechnology, Springdale, AR, USA) when the hardware system of the MNPT was designed with the aforementioned method. PMID:25875188

Hostile attribution biases for relationally provocative situations and event-related potentials.

PubMed

Godleski, Stephanie A; Ostrov, Jamie M; Houston, Rebecca J; Schlienz, Nicolas J

2010-04-01

This exploratory study investigates how hostile attribution biases for relationally provocative situations may be related to neurocognitive processing using the P300 event-related potential. Participants were 112 (45 women) emerging adults enrolled in a large, public university in upstate New York. Participants completed self-report measures on relational aggression and hostile attribution biases and performed an auditory perseveration task to elicit the P300. It was found that hostile attribution biases for relational provocation situations was associated with a larger P300 amplitude above and beyond the role of hostile attribution biases for instrumental situations, relational aggression, and gender. Larger P300 amplitude is interpreted to reflect greater allocation of cognitive resources or enhanced "attending" to salient stimuli. Implications for methodological approaches to studying aggression and hostile attribution biases and for theory are discussed, as well as implications for the fields of developmental psychology and psychopathology. Copyright 2010 Elsevier B.V. All rights reserved.

An unjustified benefit: immortal time bias in the analysis of time-dependent events.

PubMed

Gleiss, Andreas; Oberbauer, Rainer; Heinze, Georg

2018-02-01

Immortal time bias is a problem arising from methodologically wrong analyses of time-dependent events in survival analyses. We illustrate the problem by analysis of a kidney transplantation study. Following patients from transplantation to death, groups defined by the occurrence or nonoccurrence of graft failure during follow-up seemingly had equal overall mortality. Such naive analysis assumes that patients were assigned to the two groups at time of transplantation, which actually are a consequence of occurrence of a time-dependent event later during follow-up. We introduce landmark analysis as the method of choice to avoid immortal time bias. Landmark analysis splits the follow-up time at a common, prespecified time point, the so-called landmark. Groups are then defined by time-dependent events having occurred before the landmark, and outcome events are only considered if occurring after the landmark. Landmark analysis can be easily implemented with common statistical software. In our kidney transplantation example, landmark analyses with landmarks set at 30 and 60 months clearly identified graft failure as a risk factor for overall mortality. We give further typical examples from transplantation research and discuss strengths and limitations of landmark analysis and other methods to address immortal time bias such as Cox regression with time-dependent covariables. © 2017 Steunstichting ESOT.

Attentional bias modulation by reappraisal in patients with generalized anxiety disorder: an event-related potential study

PubMed Central

Han, H.Y.; Gan, T.; Li, P.; Li, Z.J.; Guo, M.; Yao, S.M.

2014-01-01

Affective states influence subsequent attention allocation. We evaluated emotional negativity bias modulation by reappraisal in patients with generalized anxiety disorder (GAD) relative to normal controls. Event-related potential (ERP) recordings were obtained, and changes in P200 and P300 amplitudes in response to negative or neutral words were noted after decreasing negative emotion or establishing a neutral condition. We found that in GAD patients only, the mean P200 amplitude after negative word presentation was much higher than after the presentation of neutral words. In normal controls, after downregulation of negative emotion, the mean P300 amplitude in response to negative words was much lower than after neutral words, and this was significant in both the left and right regions. In GAD patients, the negative bias remained prominent and was not affected by reappraisal at the early stage. Reappraisal was observed to have a lateralized effect at the late stage. PMID:24863650

Napping reduces emotional attention bias during early childhood.

PubMed

Cremone, Amanda; Kurdziel, Laura B F; Fraticelli-Torres, Ada; McDermott, Jennifer M; Spencer, Rebecca M C

2017-07-01

Sleep loss alters processing of emotional stimuli in preschool-aged children. However, the mechanism by which sleep modifies emotional processing in early childhood is unknown. We tested the hypothesis that a nap, compared to an equivalent time spent awake, reduces biases in attention allocation to affective information. Children (n = 43; M = 55.40 months, SD = 8.05 months) completed a Dot Probe task, which provides a measure of attention biases to emotional stimuli, following a mid-day nap and an equivalent interval spent awake. No emotional attention biases emerged when children napped. However, when nap-deprived, children exhibited biases towards negative and positive stimuli. This emotional bias after wake was greater in children who napped habitually. Gender differences also emerged such that females were more attentive to positive emotional stimuli whereas males showed heightened attention to negative emotional stimuli, regardless of having napped or not. Moreover, greater slow wave activity (SWA) during the nap was associated with faster responding, which suggests that SWA may promote efficiency of attention allocation. A video abstract of this article can be viewed at: https://www.youtube.com/watch?v=JIoZ8mzxQgg. © 2016 John Wiley & Sons Ltd.

Energy system contributions in middle-distance running events.

PubMed

Hill, D W

1999-06-01

The aim of this study was to estimate the energy contributions in middle-distance running events for male and female university athletes. The oxygen uptake (VO2) response during high-speed running was measured directly during exhaustive treadmill tests. Muscle mass was estimated using anthropometry. Each athlete completed an average of three races over 400 m, 800 m or 1500 m. Five minutes after each race, they provided a blood sample for determination of blood lactate concentration. For each race, energy cost, which was expressed as oxygen equivalents, was calculated as the sum of the aerobic and anaerobic components. The aerobic contribution was calculated as the sum of oxygen stores (2.3 ml O2.kg body mass-1) and total VO2 (based on the VO2 response to treadmill running). The anaerobic contribution was calculated as the sum of the energy available from phosphocreatine stores (37 ml O2.kg muscle mass-1) and the energy from glycolysis (3.0 ml O2.kg body mass-1 per mmol.l-1 increase in blood lactate concentration). For the women, the anaerobic energy contributions for the 400 m, 800 m and 1500 m averaged 62%, 33% and 17%, respectively. For the men, the anaerobic contributions averaged 63%, 39% and 20%, respectively. This information will help coaches and sport scientists to design and implement individualized training programmes.

Napping Reduces Emotional Attention Bias during Early Childhood

ERIC Educational Resources Information Center

Cremone, Amanda; Kurdziel, Laura B. F.; Fraticelli-Torres, Ada; McDermott, Jennifer M.; Spencer, Rebecca M. C.

2017-01-01

Sleep loss alters processing of emotional stimuli in preschool-aged children. However, the mechanism by which sleep modifies emotional processing in early childhood is unknown. We tested the hypothesis that a nap, compared to an equivalent time spent awake, reduces biases in attention allocation to affective information. Children (n = 43;…

Fortune Favors the Brave. Tactical Behaviors in the Middle Distance Running Events at the 2017 IAAF World Championships.

PubMed

Casado, Arturo; Renfree, Andrew

2018-05-29

To assess tactical and performance factors associated with progression from qualification rounds in the 800 m and 1500 m running events at the 2017 IAAF World Championships. Official results were used to access final and intermediate positions and times, as well as performance characteristics of competitors. Shared variance between intermediate positions and rank order lap times (ROSPT) with finishing positions were calculated, along with probability of automatic qualification, for athletes in each available race position at the end of every 400 m lap. Differences in race positions and lap times relative to season´s best (SB) performances were assessed between automatic qualifiers (AQ), fastest losers (FL), and non-qualifiers (NQ). Race positions at the end of each 400 m lap remained more stable through 800 m races than 1500 m races. Probability of automatic qualification decreased with both race position and ROSPT on each lap, although ROSPT accounted for a higher degree of shared variance than did intermediate position. In the 1500 m event FL ran at a higher percentage of SB speed, and adopted positions closer to the race lead in the early stages. This was not the case in the 800 m. Intermediate positioning and the ability to produce a fast final race segment are strongly related to advancement from qualification rounds in middle distance running events. The adoption of a more 'risky' strategy characterized by higher speeds relative to SB may be associated with increased likelihood of qualification as FL in the 1500 m event.

Seat belt pre-pretensioner effect on child-sized dummies during run-off-road events.

PubMed

Stockman, Isabelle; Bohman, Katarina; Jakobsson, Lotta

2017-05-29

Run-off-road events occur frequently and can result in severe consequences. Several potential injury-causing mechanisms can be observed in the diverse types of run-off-road events. Real-world data show that different types of environments, such as rough terrain, ditch types, and whether multiple events occur, may be important contributing factors to occupant injury. Though countermeasures addressing front seat occupants have been presented, studies on rear seat occupant retention in situations such as run-off-road events are lacking. The aim of this study was to investigate the seat belt pre-pretensioner effect on rear-seated child-sized anthropomorphic test devices (ATDs) during 2 different types of run-off-road events. The study was carried out using 2 test setups: a rig test with a vehicle rear seat mounted on a multi-axial robot simulating a road departure event into a side ditch and an in-vehicle test setup with a Volvo XC60 entering a side ditch with a grass slope, driving inside the ditch, and returning back to the road from the ditch. Potential subsequent rollovers or impacts were not included in the test setups. Three different ATDs were used. The Q6 and Q10 were seated on an integrated booster cushion and the Hybrid III (HIII) 5th percentile female was positioned directly on the seat. The seat belt retractor was equipped with a pre-pretensioner (electrical reversible retractor) with 3 force level settings. In addition, reference tests with the pre-pretensioner inactivated were run. Kinematics and the shoulder belt position were analyzed. In rig tests, the left-seated ATD was exposed to rapid inboard lateral loads relative to the vehicle. The displacement for each ATD was reduced when the pre-pretensioner was activated compared to tests when it was inactivated. Maximum inboard displacement occurred earlier in the event for all ATDs when the pre-pretensioner was activated. Shoulder belt slip-off occurred for the Q6 and Q10 in tests where the pre

Patterns of Neural Connectivity during an Attention Bias Task Moderate Associations between Early Childhood Temperament and Internalizing Symptoms in Young Adulthood

PubMed Central

Hardee, Jillian E.; Benson, Brenda E.; Bar-Haim, Yair; Mogg, Karin; Bradley, Brendan P; Chen, Gang; Britton, Jennifer C.; Ernst, Monique; Fox, Nathan A.; Pine, Daniel S.; Pérez-Edgar, Koraly

2013-01-01

Background Biased attention to threat is found in both individuals with anxiety symptoms and children with the childhood temperament of behavioral inhibition (BI). Although perturbed fronto-amygdala function is implicated in biased attention among anxious individuals, no work has examined the neural correlates of attention biases in BI. Work in this area may clarify underlying mechanisms for anxiety in a sample at risk for internalizing disorders. We examined the relations among early childhood BI, fronto-amygdala connectivity during an attention bias task in young adulthood, and internalizing symptoms, assessed in young adulthood. Methods Children were assessed for BI at multiple age points from infancy through age seven. Based on a composite of observational and maternal report data, we selected 21 young adults classified as having a history of BI and 23 classified as non-BI for this study (N=44). Participants completed an event-related fMRI attention-bias task involving threat (angry faces) and neutral trials. Internalizing symptoms were assessed by self-report and diagnostic interviews. Results The young adults characterized in childhood with BI exhibited greater strength in threat-related connectivity than non-behaviorally inhibited young adults. Between-group differences manifested in connections between the amygdala and two frontal regions: dorsolateral prefrontal cortex and anterior insula. Amygdala-insula connectivity also interacted with childhood BI to predict young adult internalizing symptoms. Conclusions BI during early childhood predicts differences as young adults in threat and attention-related fronto-amygdala connectivity. Connectivity strength, in turn, moderated the relations between early BI and later psychopathology. PMID:23489415

Bias to pollen odors is affected by early exposure and foraging experience.

PubMed

Arenas, A; Farina, W M

2014-07-01

In many pollinating insects, foraging preferences are adjusted on the basis of floral cues learned at the foraging site. In addition, olfactory experiences gained at early adult stages might also help them to initially choose food sources. To understand pollen search behavior of honeybees, we studied how responses elicited by pollen-based odors are biased in foraging-age workers according to (i) their genetic predisposition to collect pollen, (ii) pollen related information gained during foraging and (iii) different experiences with pollen gained at early adult ages. Bees returning to the hive carrying pollen loads, were strongly biased to unfamiliar pollen bouquets when tested in a food choice device against pure odors. Moreover, pollen foragers' orientation response was specific to the odors emitted by the pollen type they were carrying on their baskets, which suggests that foragers retrieve pollen odor information to recognize rewarding flowers outside the hive. We observed that attraction to pollen odor was mediated by the exposure to a pollen diet during the first week of life. We did not observe the same attraction in foraging-age bees early exposed to an artificial diet that did not contain pollen. Contrary to the specific response observed to cues acquired during foraging, early exposure to single-pollen diets did not bias orientation response towards a specific pollen odor in foraging-age bees (i.e. bees chose equally between the exposed and the novel monofloral pollen odors). Our results show that pollen exposure at early ages together with olfactory experiences gained in a foraging context are both relevant to bias honeybees' pollen search behavior. Copyright © 2014 Elsevier Ltd. All rights reserved.

Interpopulation Comparison of Sex-Biased Mortality and Sexual Size Dimorphism in Sea-Run Masu Salmon, Oncorhynchus masou.

PubMed

Tamate, Tsuyoshi

2015-08-01

Evolutionary ecologists often expect that natural and sexual selection result in systematic co-occurrence patterns of sex-biased mortality and sexual size dimorphism (SSD) within animal species. However, whether such patterns actually occur in wild animals is poorly examined. The following expectation, the larger sex suffers higher mortality, was primarily tested here for apparently native sea-run masu salmon (Oncorhynchus masou) in three populations in Hokkaido, Japan. Field surveys on sex ratios, body sizes, and ages of smolts and returning adults revealed that two of the three populations exhibited an expected pattern, a female-biased marine mortality and SSD, but one population demonstrated an unexpected co-occurrence of male-biased marine mortality and female-biased SSD. These female-biased SSDs were attributed to faster marine growth of females because of no sex difference in smolt body size. It has been previously suggested that breeding selection favoring large size generally act more strongly in females than in males in Japanese anadromous masu, as there is a weak sexual selection on adult males but universally intensive natural selection on adult females. Thus, this hypothesis explains female-biased SSDs well in all study populations. Interpopulation variation in sex-biased mortality found here might result from differences in marine predation and/or fishing pressures, given that selection driving female-biased SSD makes females forage more aggressively than males during the marine phase. Taken together, these results raise the possibility that evolutionary forces have shaped adaptive sex-specific foraging strategies under relationships between growth and mortality, resulting in co-occurrence patterns of sex-biased mortality and SSD within animal species.

Detection and Attribution of Simulated Climatic Extreme Events and Impacts: High Sensitivity to Bias Correction

NASA Astrophysics Data System (ADS)

Sippel, S.; Otto, F. E. L.; Forkel, M.; Allen, M. R.; Guillod, B. P.; Heimann, M.; Reichstein, M.; Seneviratne, S. I.; Kirsten, T.; Mahecha, M. D.

2015-12-01

Understanding, quantifying and attributing the impacts of climatic extreme events and variability is crucial for societal adaptation in a changing climate. However, climate model simulations generated for this purpose typically exhibit pronounced biases in their output that hinders any straightforward assessment of impacts. To overcome this issue, various bias correction strategies are routinely used to alleviate climate model deficiencies most of which have been criticized for physical inconsistency and the non-preservation of the multivariate correlation structure. We assess how biases and their correction affect the quantification and attribution of simulated extremes and variability in i) climatological variables and ii) impacts on ecosystem functioning as simulated by a terrestrial biosphere model. Our study demonstrates that assessments of simulated climatic extreme events and impacts in the terrestrial biosphere are highly sensitive to bias correction schemes with major implications for the detection and attribution of these events. We introduce a novel ensemble-based resampling scheme based on a large regional climate model ensemble generated by the distributed weather@home setup[1], which fully preserves the physical consistency and multivariate correlation structure of the model output. We use extreme value statistics to show that this procedure considerably improves the representation of climatic extremes and variability. Subsequently, biosphere-atmosphere carbon fluxes are simulated using a terrestrial ecosystem model (LPJ-GSI) to further demonstrate the sensitivity of ecosystem impacts to the methodology of bias correcting climate model output. We find that uncertainties arising from bias correction schemes are comparable in magnitude to model structural and parameter uncertainties. The present study consists of a first attempt to alleviate climate model biases in a physically consistent way and demonstrates that this yields improved simulations of

A new design approach to achieve a minimum impulse limit cycle in the presence of significant measurement uncertainties

NASA Technical Reports Server (NTRS)

Martin, M. W.; Kubiak, E. T.

1982-01-01

A new design was developed for the Space Shuttle Transition Phase Digital Autopilot to reduce the impact of large measurement uncertainties in the rate signal during attitude control. The signal source, which was dictated by early computer constraints, is characterized by large quantization, noise, bias, and transport lag which produce a measurement uncertainty larger than the minimum impulse rate change. To ensure convergence to a minimum impulse limit cycle, the design employed bias and transport lag compensation and a switching logic with hysteresis, rate deadzone, and 'walking' switching line. The design background, the rate measurement uncertainties, and the design solution are documented.

[Effective size of subpopulation of the early run sockeye salmon Oncorhynchus nerka from Azabach's Lake (Kamchatka): effect of density on variance of reproductive success].

PubMed

Efremov, V V; Parenskiĭ, V A

2004-04-01

Using Parensky's approach for estimating the number of breeding pairs, we determined effective subpopulation size Ne in early-run sockeye salmon Oncorhynchus nerka from Azabach'e Lake (Kamchatka) in 1977 through 1981. On average (over years and populations), biased sex ratio decreased Ne by 7% as compared to the number of fish on the spawning sites (Ni). High density reduced the Ne/Ni ratio by 62-66% because some fish were excluded from spawning. Dominance polygyny as compared to monogamy and random union of gametes could reduce Ne by about 17%.

Patterns of neural connectivity during an attention bias task moderate associations between early childhood temperament and internalizing symptoms in young adulthood.

PubMed

Hardee, Jillian E; Benson, Brenda E; Bar-Haim, Yair; Mogg, Karin; Bradley, Brendan P; Chen, Gang; Britton, Jennifer C; Ernst, Monique; Fox, Nathan A; Pine, Daniel S; Pérez-Edgar, Koraly

2013-08-15

Biased attention to threat is found in both individuals with anxiety symptoms and children with the childhood temperament of behavioral inhibition (BI). Although perturbed fronto-amygdala function is implicated in biased attention among anxious individuals, no work has examined the neural correlates of attention biases in BI. Work in this area might clarify underlying mechanisms for anxiety in a sample at risk for internalizing disorders. We examined the relations among early childhood BI, fronto-amygdala connectivity during an attention bias task in young adulthood, and internalizing symptoms, assessed in young adulthood. Children were assessed for BI at multiple age points from infancy through age seven. On the basis of a composite of observational and maternal report data, we selected 21 young adults classified as having a history of BI and 23 classified as non-BI for this study (n = 44). Participants completed an event-related functional magnetic resonance imaging attention-bias task involving threat (angry faces) and neutral trials. Internalizing symptoms were assessed by self-report and diagnostic interviews. The young adults characterized in childhood with BI exhibited greater strength in threat-related connectivity than non-behaviorally inhibited young adults. Between-group differences manifested in connections between the amygdala and two frontal regions: dorsolateral prefrontal cortex and anterior insula. Amygdala-insula connectivity also interacted with childhood BI to predict young adult internalizing symptoms. Behavioral inhibition during early childhood predicts differences as young adults in threat and attention-related fronto-amygdala connectivity. Connectivity strength, in turn, moderated the relations between early BI and later psychopathology. Copyright © 2013 Society of Biological Psychiatry. All rights reserved.

VO2 attained during treadmill running: the influence of a specialist (400-m or 800-m) event.

PubMed

James, David V B; Sandals, Leigh E; Draper, Stephen B; Maldonado-Martin, Sara; Wood, Dan M

2007-06-01

Previously it has been observed that, in well-trained 800-m athletes, VO2max is not attained during middle-distance running events on a treadmill, even when a race-type pacing strategy is adopted. Therefore, the authors investigated whether specialization in a particular running distance (400-m or 800-m) influences the VO2 attained during running on a treadmill. Six 400-m and six 800-m running specialists participated in the study.A 400-m trial and a progressive test to determine VO2max were completed in a counterbalanced order. Oxygen uptakes attained during the 400-m trial were compared to examine the influence of specialist event. A VO2 plateau was observed in all participants for the progressive test, demonstrating the attainment of VO2max. The VO2max values were 56.2 +/- 4.7 and 69.3 +/- 4.5 mL x kg-1 x min-1 for the 400-m- and 800-m-event specialists, respectively (P = .0003). Durations for the 400-m trial were 55.1 +/- 4.2 s and 55.8 +/- 2.3 s for the 400-m- and 800-m-event specialists, respectively. The VO2 responses achieved were 93.1% +/- 2.0% and 85.7% +/- 3.0% VO2max for the 400-m- and 800-m-event specialists, respectively (P = .001). These results demonstrate that specialist running events do appear to influence the percentage of VO2max achieved in the 400-m trial, with the 800-m specialists attaining a lower percentage of VO2max than the 400-m specialists. The 400-m specialists appear to compensate for a lower VO2max by attaining a higher percentage VO2max during a 400-m trial.

Relationship between jumping ability and running performance in events of varying distance.

PubMed

Hudgins, Brandon; Scharfenberg, Jessica; Triplett, N Travis; McBride, Jeffrey M

2013-03-01

Running performance consists of a combination of aerobic and anaerobic capabilities, varying based on the distance of the event. It may be also dependent on factors relating to lower body power. Lower body power is commonly assessed by various modes of jumping tests. The purpose of this investigation was to determine if jumping performance would have some relationship to running performance in different distance events. This study involved 33 competitive track and field runners who participated in events ranging from 60 to 5,000 m (10 sprinters: height = 1.72 ± 10.26 m, mass = 67.80 ± 10.83 kg; 11 middle-distance runners: height = 1.77 ± 0.08 m, mass = 64.40 ± 8.02 kg; 12 long-distance runners: height = 1.73 ± 0.11 m, mass = 60.42 ± 10.36 kg). All subjects were competitive NCAA Division I athletes. Subjects were tested on a single occasion in a 3-jump test (TSJP), which was the distance covered during 3 two-leg standing long jumps performed in immediate succession. Time in the 60, 100, 200, 800, 3,000, and 5,000 m was obtained from recent race performances. The mean TSJP for sprinters, middle-distance runners, and long-distance runners were 8.24 ± 1.32, 6.59 ± 1.23, and 5.61 ± 0.88 m, respectively. The mean 60, 100, 200, 800, 3,000, and 5,000 m performances were 7.28 ± 0.78, 11.25 ± 0.87, 23.47 ± 2.25, 127.17 ± 15.13, 562.09 ± 60.54, and 987.65 ± 117.19 seconds, respectively. Significant correlations (p ≤ 0.05) were observed between TSJP and running performance for all distances (60 m: 0.97 seconds, 100 m: 1.00 seconds, 200 m: 0.97 seconds, 800 m: 0.83 seconds, 3,000 m: 0.72 seconds, and 5,000 m: 0.71 seconds). The strength of the correlations, in general, was strongest to weakest based on event distance from the shortest distance (60 m) to the longest distance (5,000 m). Thus, the contribution of muscle power, as possibly determined by TSJP, maybe most important in shorter distance races (60, 100, and 200 m). However, because of the significant

Who Participates in Running Events? Socio-Demographic Characteristics, Psychosocial Factors and Barriers as Correlates of Non-Participation—A Pilot Study in Belgium

PubMed Central

de Ridder, Lisa; Willem, Annick

2017-01-01

In Western countries, the popularity of running events has increased exponentially during the last three decades. However, little is known about the profile of non-participants. This knowledge is crucial to tailor promotional actions towards people who are currently not participating. Therefore, this study aimed: (1) to examine which socio-ecological factors are related to participation in running events, (2) to give an overview of the barriers towards participation, and (3) to examine differences in barriers depending on gender, age and educational level. Flemish adults (n = 308) completed an online questionnaire about their socio-demographic and psychosocial characteristics, physical activity levels, participation in running events and barriers towards participation. Results showed that motivation, family social support, knowledge about running events and physical activity levels were associated with participation in running events. Among non-participants, the main barriers were bad physical condition, lack of time and lack of interest. In participants, lack of time, distance to the event and financial barriers were most prevalent. With some exceptions, barriers were relatively similar across socio-demographic subgroups. This study confirmed a democratization among participants of running events and provided evidence about which barriers should be tackled to increase participation among population subgroups that are currently underrepresented in such events. PMID:29143780

Who Participates in Running Events? Socio-Demographic Characteristics, Psychosocial Factors and Barriers as Correlates of Non-Participation-A Pilot Study in Belgium.

PubMed

van Dyck, Delfien; Cardon, Greet; de Bourdeaudhuij, Ilse; de Ridder, Lisa; Willem, Annick

2017-10-28

In Western countries, the popularity of running events has increased exponentially during the last three decades. However, little is known about the profile of non-participants. This knowledge is crucial to tailor promotional actions towards people who are currently not participating. Therefore, this study aimed: (1) to examine which socio-ecological factors are related to participation in running events, (2) to give an overview of the barriers towards participation, and (3) to examine differences in barriers depending on gender, age and educational level. Flemish adults ( n = 308) completed an online questionnaire about their socio-demographic and psychosocial characteristics, physical activity levels, participation in running events and barriers towards participation. Results showed that motivation, family social support, knowledge about running events and physical activity levels were associated with participation in running events. Among non-participants, the main barriers were bad physical condition, lack of time and lack of interest. In participants, lack of time, distance to the event and financial barriers were most prevalent. With some exceptions, barriers were relatively similar across socio-demographic subgroups. This study confirmed a democratization among participants of running events and provided evidence about which barriers should be tackled to increase participation among population subgroups that are currently underrepresented in such events.

Advanced Biasing Experiments on the C-2 Field-Reversed Configuration Device

NASA Astrophysics Data System (ADS)

Thompson, Matthew; Korepanov, Sergey; Garate, Eusebio; Yang, Xiaokang; Gota, Hiroshi; Douglass, Jon; Allfrey, Ian; Valentine, Travis; Uchizono, Nolan; TAE Team

2014-10-01

The C-2 experiment seeks to study the evolution, heating and sustainment effects of neutral beam injection on field-reversed configuration (FRC) plasmas. Recently, substantial improvements in plasma performance were achieved through the application of edge biasing with coaxial plasma guns located in the divertors. Edge biasing provides rotation control that reduces instabilities and E × B shear that improves confinement. Typically, the plasma gun arcs are run at ~ 10 MW for the entire shot duration (~ 5 ms), which will become unsustainable as the plasma duration increases. We have conducted several advanced biasing experiments with reduced-average-power plasma gun operating modes and alternative biasing cathodes in an effort to develop an effective biasing scenario applicable to steady state FRC plasmas. Early results show that several techniques can potentially provide effective, long-duration edge biasing.

Version 4 IMERG: Investigating Runs and High Latitudes

NASA Astrophysics Data System (ADS)

Huffman, G. J.; Bolvin, D. T.; Braithwaite, D.; Hsu, K. L.; Joyce, R.; Kidd, C.; Nelkin, E. J.; Sorooshian, S.; Tan, J.; Xie, P.

2016-12-01

The Integrated Multi-satellitE Retrievals for GPM (IMERG) merged precipitation product is being computed by the U.S. Global Precipitation Measurement mission (GPM) science team, based on intercalibrated estimates from the international constellation of precipitation-relevant satellites and other data. Recently, GPM upgraded the precipitation retrieval algorithms applied to individual sensors, and following that, IMERG was upgraded to Version 4. These data sets are computed at the half hour, 0.1° x 0.1° resolution over the latitude belt 60°N-S. Various latency requirements for different users are accommodated by computing IMERG in three "Runs" - Early, Late, and Final (5 hours, 15 hours, and 2.5 months after observation time, respectively). The near-real-time Early and Late Runs and the research-quality Final Run incorporate increasing amounts of data; examples will highlight the contribution that additional data make for each Run. From Early to Late, the addition of backward propagated data in the Late allows temporally weighted interpolation of forward and backward propagated precipitation, rather than the forward-only extrapolation in the Early. From Late to Final, the major addition is the direct use of monthly precipitation gauge analysis (the Global Precipitation Climatology Centre's Monitoring Analysis), which mitigates the satellite biases over land for the Early and Late. In addition, the new capabilities of the input algorithms at higher latitudes will be discussed, both during the snow season and the summer rain season. These inputs have a dominant role in determining the utility of IMERG in all seasons. Rainfall over non-frozen surface is reasonably well represented, while precipitation over frozen surfaces is still a topic of active research.

Considerations for analysis of time-to-event outcomes measured with error: Bias and correction with SIMEX.

PubMed

Oh, Eric J; Shepherd, Bryan E; Lumley, Thomas; Shaw, Pamela A

2018-04-15

For time-to-event outcomes, a rich literature exists on the bias introduced by covariate measurement error in regression models, such as the Cox model, and methods of analysis to address this bias. By comparison, less attention has been given to understanding the impact or addressing errors in the failure time outcome. For many diseases, the timing of an event of interest (such as progression-free survival or time to AIDS progression) can be difficult to assess or reliant on self-report and therefore prone to measurement error. For linear models, it is well known that random errors in the outcome variable do not bias regression estimates. With nonlinear models, however, even random error or misclassification can introduce bias into estimated parameters. We compare the performance of 2 common regression models, the Cox and Weibull models, in the setting of measurement error in the failure time outcome. We introduce an extension of the SIMEX method to correct for bias in hazard ratio estimates from the Cox model and discuss other analysis options to address measurement error in the response. A formula to estimate the bias induced into the hazard ratio by classical measurement error in the event time for a log-linear survival model is presented. Detailed numerical studies are presented to examine the performance of the proposed SIMEX method under varying levels and parametric forms of the error in the outcome. We further illustrate the method with observational data on HIV outcomes from the Vanderbilt Comprehensive Care Clinic. Copyright © 2017 John Wiley & Sons, Ltd.

Advanced overlay: sampling and modeling for optimized run-to-run control

NASA Astrophysics Data System (ADS)

Subramany, Lokesh; Chung, WoongJae; Samudrala, Pavan; Gao, Haiyong; Aung, Nyan; Gomez, Juan Manuel; Gutjahr, Karsten; Park, DongSuk; Snow, Patrick; Garcia-Medina, Miguel; Yap, Lipkong; Demirer, Onur Nihat; Pierson, Bill; Robinson, John C.

2016-03-01

In recent years overlay (OVL) control schemes have become more complicated in order to meet the ever shrinking margins of advanced technology nodes. As a result, this brings up new challenges to be addressed for effective run-to- run OVL control. This work addresses two of these challenges by new advanced analysis techniques: (1) sampling optimization for run-to-run control and (2) bias-variance tradeoff in modeling. The first challenge in a high order OVL control strategy is to optimize the number of measurements and the locations on the wafer, so that the "sample plan" of measurements provides high quality information about the OVL signature on the wafer with acceptable metrology throughput. We solve this tradeoff between accuracy and throughput by using a smart sampling scheme which utilizes various design-based and data-based metrics to increase model accuracy and reduce model uncertainty while avoiding wafer to wafer and within wafer measurement noise caused by metrology, scanner or process. This sort of sampling scheme, combined with an advanced field by field extrapolated modeling algorithm helps to maximize model stability and minimize on product overlay (OPO). Second, the use of higher order overlay models means more degrees of freedom, which enables increased capability to correct for complicated overlay signatures, but also increases sensitivity to process or metrology induced noise. This is also known as the bias-variance trade-off. A high order model that minimizes the bias between the modeled and raw overlay signature on a single wafer will also have a higher variation from wafer to wafer or lot to lot, that is unless an advanced modeling approach is used. In this paper, we characterize the bias-variance trade off to find the optimal scheme. The sampling and modeling solutions proposed in this study are validated by advanced process control (APC) simulations to estimate run-to-run performance, lot-to-lot and wafer-to- wafer model term monitoring to

Biased gene expression in early honeybee larval development

PubMed Central

2013-01-01

Background Female larvae of the honeybee (Apis mellifera) develop into either queens or workers depending on nutrition. This nutritional stimulus triggers different developmental trajectories, resulting in adults that differ from each other in physiology, behaviour and life span. Results To understand how these trajectories are established we have generated a comprehensive atlas of gene expression throughout larval development. We found substantial differences in gene expression between worker and queen-destined larvae at 6 hours after hatching. Some of these early changes in gene expression are maintained throughout larval development, indicating that caste-specific developmental trajectories are established much earlier than previously thought. Within our gene expression data we identified processes that potentially underlie caste differentiation. Queen-destined larvae have higher expression of genes involved in transcription, translation and protein folding early in development with a later switch to genes involved in energy generation. Using RNA interference, we were able to demonstrate that one of these genes, hexamerin 70b, has a role in caste differentiation. Both queen and worker developmental trajectories are associated with the expression of genes that have alternative splice variants, although only a single variant of a gene tends to be differentially expressed in a given caste. Conclusions Our data, based on the biases in gene expression early in development together with published data, supports the idea that caste development in the honeybee consists of two phases; an initial biased phase of development, where larvae can still switch to the other caste by differential feeding, followed by commitment to a particular developmental trajectory. PMID:24350621

Incidence of Running-Related Injuries Per 1000 h of running in Different Types of Runners: A Systematic Review and Meta-Analysis.

PubMed

Videbæk, Solvej; Bueno, Andreas Moeballe; Nielsen, Rasmus Oestergaard; Rasmussen, Sten

2015-07-01

No systematic review has identified the incidence of running-related injuries per 1000 h of running in different types of runners. The purpose of the present review was to systematically search the literature for the incidence of running-related injuries per 1000 h of running in different types of runners, and to include the data in meta-analyses. A search of the PubMed, Scopus, SPORTDiscus, PEDro and Web of Science databases was conducted. Titles, abstracts, and full-text articles were screened by two blinded reviewers to identify prospective cohort studies and randomized controlled trials reporting the incidence of running-related injuries in novice runners, recreational runners, ultra-marathon runners, and track and field athletes. Data were extracted from all studies and comprised for further analysis. An adapted scale was applied to assess the risk of bias. After screening 815 abstracts, 13 original articles were included in the main analysis. Running-related injuries per 1000 h of running ranged from a minimum of 2.5 in a study of long-distance track and field athletes to a maximum of 33.0 in a study of novice runners. The meta-analyses revealed a weighted injury incidence of 17.8 (95% confidence interval [CI] 16.7-19.1) in novice runners and 7.7 (95% CI 6.9-8.7) in recreational runners. Heterogeneity in definitions of injury, definition of type of runner, and outcome measures in the included full-text articles challenged comparison across studies. Novice runners seem to face a significantly greater risk of injury per 1000 h of running than recreational runners.

The small-x gluon distribution in centrality biased pA and pp collisions

DOE PAGES

Dumitru, Adrian; Kapilevich, Gary; Skokov, Vladimir

2018-04-04

Here, the nuclear modification factor R pA(p T) provides information on the small- x gluon distribution of a nucleus at hadron colliders. Several experiments have recently measured the nuclear modification factor not only in minimum bias but also for central pA collisions. In this paper we analyze the bias on the configurations of soft gluon fields introduced by a centrality selection via the number of hard particles. Such bias can be viewed as reweighting of configurations of small- x gluons. We find that the biased nuclear modification factor Q pA(p T) for central collisions is above R pA(p T) formore » minimum bias events, and that it may redevelop a “Cronin peak” even at small x . The magnitude of the peak is predicted to increase approximately like 1/A ⊥ ν, ν~0.6±0.1 , if one is able to select more compact configurations of the projectile proton where its gluons occupy a smaller transverse area A ⊥. We predict an enhanced Q pp(p T)–1~1/(p T 2) ν and a Cronin peak even for central pp collisions.« less

The small-x gluon distribution in centrality biased pA and pp collisions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dumitru, Adrian; Kapilevich, Gary; Skokov, Vladimir

Here, the nuclear modification factor R pA(p T) provides information on the small- x gluon distribution of a nucleus at hadron colliders. Several experiments have recently measured the nuclear modification factor not only in minimum bias but also for central pA collisions. In this paper we analyze the bias on the configurations of soft gluon fields introduced by a centrality selection via the number of hard particles. Such bias can be viewed as reweighting of configurations of small- x gluons. We find that the biased nuclear modification factor Q pA(p T) for central collisions is above R pA(p T) formore » minimum bias events, and that it may redevelop a “Cronin peak” even at small x . The magnitude of the peak is predicted to increase approximately like 1/A ⊥ ν, ν~0.6±0.1 , if one is able to select more compact configurations of the projectile proton where its gluons occupy a smaller transverse area A ⊥. We predict an enhanced Q pp(p T)–1~1/(p T 2) ν and a Cronin peak even for central pp collisions.« less

The small-x gluon distribution in centrality biased pA and pp collisions

NASA Astrophysics Data System (ADS)

Dumitru, Adrian; Kapilevich, Gary; Skokov, Vladimir

2018-06-01

The nuclear modification factor RpA (pT) provides information on the small-x gluon distribution of a nucleus at hadron colliders. Several experiments have recently measured the nuclear modification factor not only in minimum bias but also for central pA collisions. In this paper we analyze the bias on the configurations of soft gluon fields introduced by a centrality selection via the number of hard particles. Such bias can be viewed as reweighting of configurations of small-x gluons. We find that the biased nuclear modification factor QpA (pT) for central collisions is above RpA (pT) for minimum bias events, and that it may redevelop a "Cronin peak" even at small x. The magnitude of the peak is predicted to increase approximately like 1 /A⊥ ν, ν ∼ 0.6 ± 0.1, if one is able to select more compact configurations of the projectile proton where its gluons occupy a smaller transverse area A⊥. We predict an enhanced Qpp (pT) - 1 ∼ 1 /(pT2) ν and a Cronin peak even for central pp collisions.

Rising above the Minimum Wage.

ERIC Educational Resources Information Center

Even, William; Macpherson, David

An in-depth analysis was made of how quickly most people move up the wage scale from minimum wage, what factors influence their progress, and how minimum wage increases affect wage growth above the minimum. Very few workers remain at the minimum wage over the long run, according to this study of data drawn from the 1977-78 May Current Population…

Feature Biases in Early Word Learning: Network Distinctiveness Predicts Age of Acquisition

ERIC Educational Resources Information Center

Engelthaler, Tomas; Hills, Thomas T.

2017-01-01

Do properties of a word's features influence the order of its acquisition in early word learning? Combining the principles of mutual exclusivity and shape bias, the present work takes a network analysis approach to understanding how feature distinctiveness predicts the order of early word learning. Distance networks were built from nouns with edge…

Nonlinear unbiased minimum-variance filter for Mars entry autonomous navigation under large uncertainties and unknown measurement bias.

PubMed

Xiao, Mengli; Zhang, Yongbo; Fu, Huimin; Wang, Zhihua

2018-05-01

High-precision navigation algorithm is essential for the future Mars pinpoint landing mission. The unknown inputs caused by large uncertainties of atmospheric density and aerodynamic coefficients as well as unknown measurement biases may cause large estimation errors of conventional Kalman filters. This paper proposes a derivative-free version of nonlinear unbiased minimum variance filter for Mars entry navigation. This filter has been designed to solve this problem by estimating the state and unknown measurement biases simultaneously with derivative-free character, leading to a high-precision algorithm for the Mars entry navigation. IMU/radio beacons integrated navigation is introduced in the simulation, and the result shows that with or without radio blackout, our proposed filter could achieve an accurate state estimation, much better than the conventional unscented Kalman filter, showing the ability of high-precision Mars entry navigation algorithm. Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.

Immortal time bias in observational studies of time-to-event outcomes.

PubMed

Jones, Mark; Fowler, Robert

2016-12-01

The purpose of the study is to show, through simulation and example, the magnitude and direction of immortal time bias when an inappropriate analysis is used. We compare 4 methods of analysis for observational studies of time-to-event outcomes: logistic regression, standard Cox model, landmark analysis, and time-dependent Cox model using an example data set of patients critically ill with influenza and a simulation study. For the example data set, logistic regression, standard Cox model, and landmark analysis all showed some evidence that treatment with oseltamivir provides protection from mortality in patients critically ill with influenza. However, when the time-dependent nature of treatment exposure is taken account of using a time-dependent Cox model, there is no longer evidence of a protective effect of treatment. The simulation study showed that, under various scenarios, the time-dependent Cox model consistently provides unbiased treatment effect estimates, whereas standard Cox model leads to bias in favor of treatment. Logistic regression and landmark analysis may also lead to bias. To minimize the risk of immortal time bias in observational studies of survival outcomes, we strongly suggest time-dependent exposures be included as time-dependent variables in hazard-based analyses. Copyright © 2016 Elsevier Inc. All rights reserved.

Unfairness of Certain Events in the Olympic Games

PubMed Central

Khosla, T.

1968-01-01

Boxing, weight-lifting, wrestling, and judo are graded events in that opponents are matched by weight. If protection were to be denied by removing this restriction such sports would overwhelmingly favour the heavyweights. Data on Olympic winners show that many running and jumping events are seriously biased in favour of the very tall. It is suggested that the rules of these events should be revised to include a grading by height. This would remedy an element of unfairness in many athletic contests, beginning at school. PMID:5696539

Unfairness of certain events in the Olympic games.

PubMed

Khosla, T

1968-10-12

Boxing, weight-lifting, wrestling, and judo are graded events in that opponents are matched by weight. If protection were to be denied by removing this restriction such sports would overwhelmingly favour the heavyweights. Data on Olympic winners show that many running and jumping events are seriously biased in favour of the very tall. It is suggested that the rules of these events should be revised to include a grading by height. This would remedy an element of unfairness in many athletic contests, beginning at school.

Atmospheric pCO2 reconstructed across five early Eocene global warming events

NASA Astrophysics Data System (ADS)

Cui, Ying; Schubert, Brian A.

2017-11-01

Multiple short-lived global warming events, known as hyperthermals, occurred during the early Eocene (56-52 Ma). Five of these events - the Paleocene-Eocene Thermal Maximum (PETM or ETM1), H1 (or ETM2), H2, I1, and I2 - are marked by a carbon isotope excursion (CIE) within both marine and terrestrial sediments. The magnitude of CIE, which is a function of the amount and isotopic composition of carbon added to the ocean-atmosphere system, varies significantly between marine versus terrestrial substrates. Here we use the increase in carbon isotope fractionation by C3 land plants in response to increased pCO2 to reconcile this difference and reconstruct a range of background pCO2 and peak pCO2 for each CIE, provided two potential carbon sources: methane hydrate destabilization and permafrost-thawing/organic matter oxidation. Although the uncertainty on each pCO2 estimate using this approach is low (e.g., median uncertainty = + 23% / - 18%), this work highlights the potential for significant systematic bias in the pCO2 estimate resulting from sampling resolution, substrate type, diagenesis, and environmental change. Careful consideration of each of these factors is required especially when applying this approach to a single marine-terrestrial CIE pair. Given these limitations, we provide an upper estimate for background early Eocene pCO2 of 463 +248/-131 ppmv (methane hydrate scenario) to 806 +127/-104 ppmv (permafrost-thawing/organic matter oxidation scenario). These results, which represent the first pCO2 proxy estimates directly tied to the Eocene hyperthermals, demonstrate that early Eocene warmth was supported by background pCO2 less than ∼3.5× preindustrial levels and that pCO2 > 1000 ppmv may have occurred only briefly, during hyperthermal events.

Accounting for Selection Bias in Studies of Acute Cardiac Events.

PubMed

Banack, Hailey R; Harper, Sam; Kaufman, Jay S

2018-06-01

In cardiovascular research, pre-hospital mortality represents an important potential source of selection bias. Inverse probability of censoring weights are a method to account for this source of bias. The objective of this article is to examine and correct for the influence of selection bias due to pre-hospital mortality on the relationship between cardiovascular risk factors and all-cause mortality after an acute cardiac event. The relationship between the number of cardiovascular disease (CVD) risk factors (0-5; smoking status, diabetes, hypertension, dyslipidemia, and obesity) and all-cause mortality was examined using data from the Atherosclerosis Risk in Communities (ARIC) study. To illustrate the magnitude of selection bias, estimates from an unweighted generalized linear model with a log link and binomial distribution were compared with estimates from an inverse probability of censoring weighted model. In unweighted multivariable analyses the estimated risk ratio for mortality ranged from 1.09 (95% confidence interval [CI], 0.98-1.21) for 1 CVD risk factor to 1.95 (95% CI, 1.41-2.68) for 5 CVD risk factors. In the inverse probability of censoring weights weighted analyses, the risk ratios ranged from 1.14 (95% CI, 0.94-1.39) to 4.23 (95% CI, 2.69-6.66). Estimates from the inverse probability of censoring weighted model were substantially greater than unweighted, adjusted estimates across all risk factor categories. This shows the magnitude of selection bias due to pre-hospital mortality and effect on estimates of the effect of CVD risk factors on mortality. Moreover, the results highlight the utility of using this method to address a common form of bias in cardiovascular research. Copyright © 2018 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

Facial affect processing in social anxiety disorder with early onset: evidence of an intensity amplification bias.

PubMed

Schwab, Daniela; Schienle, Anne

2018-06-01

The present event-related potential (ERP) study investigated for the first time whether children with early-onset social anxiety disorder (SAD) process affective facial expressions of varying intensities differently than non-anxious controls. Participants were 15 SAD patients and 15 non-anxious controls (mean age of 9 years). They were presented with schematic faces displaying anger and happiness at four intensity levels (25%, 50%, 75%, and 100%), as well as with neutral faces. ERPs in early and later time windows (P100, N170, late positivity [LP]), as well as affective ratings (valence and arousal) for the faces, were recorded. SAD patients rated the faces as generally more arousing, regardless of the type of emotion and intensity. Moreover, they displayed enhanced right-parietal LP (350-650 ms). Both arousal ratings and LP reflect stimulus intensity. Therefore, this study provides first evidence of an intensity amplification bias in pediatric SAD during facial affect processing.

Collectivity and manifestations of minimum-bias jets in high-energy nuclear collisions

NASA Astrophysics Data System (ADS)

Trainor, Thomas A.

2018-01-01

Collectivity, as interpreted to mean flow of a dense medium in high-energy A-A collisions described by hydrodynamics, has been attributed to smaller collision systems - p-A and even p-p collisions - based on recent analysis of LHC data. However, alternative methods reveal that some data features attributed to flows are actually manifestations of minimum-bias (MB) jets. In this presentation I review the differential structure of single-particle pt spectra from SPS to LHC energies in the context of a two-component (soft + hard) model (TCM) of hadron production. I relate the spectrum hard component to measured properties of isolated jets. I use the spectrum TCM to predict accurately the systematics of ensemble-mean p̅t in p-p, p-A and A-A collision systems over a large energy interval. Detailed comparisons of the TCM with spectrum and correlation data suggest that MB jets play a dominant role in hadron production near midrapidity. Claimed flow phenomena are better explained as jet manifestations agreeing quantitatively with measured jet properties.

Fermi/LAT search for counterpart to the IceCube event 67093193 (run 127853)

NASA Astrophysics Data System (ADS)

Vianello, G.; Magill, J. D.; Omodei, N.; Kocevski, D.; Ajello, M.; Buson, S.; Krauss, F.; Chiang, J.

2016-04-01

on behalf of the Fermi-LAT team: We have searched the Fermi Large Area Telescope data for a high-energy gamma-ray counterpart for the IceCube High Energy Starting Event (HESE) 67093193, detected in run 127853 on 2016-04-27 05:52:32.00 UT (AMON GCN notice rev. 2, http://gcn.gsfc.nasa.gov/notices_amon/67093193_127853.amon . See http://gcn.gsfc.nasa.gov/doc/Public_Doc_AMON_IceCube_GCN_Alerts_v2.pdf for a description of HESE events and related GCN notices).

Developmental Differences in the Effects of Repeated Interviews and Interviewer Bias on Young Children's Event Memory and False Reports

ERIC Educational Resources Information Center

Quas, Jodi A.; Malloy, Lindsay C.; Melinder, Annika; Goodman, Gail S.; D'Mello, Michelle; Schaaf, Jennifer

2007-01-01

The present study investigated developmental differences in the effects of repeated interviews and interviewer bias on children's memory and suggestibility. Three- and 5-year-olds were singly or repeatedly interviewed about a play event by a highly biased or control interviewer. Children interviewed once by the biased interviewer after a long…

Priming psychic and conjuring abilities of a magic demonstration influences event interpretation and random number generation biases

PubMed Central

Mohr, Christine; Koutrakis, Nikolaos; Kuhn, Gustav

2015-01-01

Magical ideation and belief in the paranormal is considered to represent a trait-like character; people either believe in it or not. Yet, anecdotes indicate that exposure to an anomalous event can turn skeptics into believers. This transformation is likely to be accompanied by altered cognitive functioning such as impaired judgments of event likelihood. Here, we investigated whether the exposure to an anomalous event changes individuals’ explicit traditional (religious) and non-traditional (e.g., paranormal) beliefs as well as cognitive biases that have previously been associated with non-traditional beliefs, e.g., repetition avoidance when producing random numbers in a mental dice task. In a classroom, 91 students saw a magic demonstration after their psychology lecture. Before the demonstration, half of the students were told that the performance was done respectively by a conjuror (magician group) or a psychic (psychic group). The instruction influenced participants’ explanations of the anomalous event. Participants in the magician, as compared to the psychic group, were more likely to explain the event through conjuring abilities while the reverse was true for psychic abilities. Moreover, these explanations correlated positively with their prior traditional and non-traditional beliefs. Finally, we observed that the psychic group showed more repetition avoidance than the magician group, and this effect remained the same regardless of whether assessed before or after the magic demonstration. We conclude that pre-existing beliefs and contextual suggestions both influence people’s interpretations of anomalous events and associated cognitive biases. Beliefs and associated cognitive biases are likely flexible well into adulthood and change with actual life events. PMID:25653626

Do minimum wages improve early life health? Evidence from developing countries.

PubMed

Majid, Muhammad Farhan; Mendoza Rodríguez, José M; Harper, Sam; Frank, John; Nandi, Arijit

2016-06-01

The impact of legislated minimum wages on the early-life health of children living in low and middle-income countries has not been examined. For our analyses, we used data from the Demographic and Household Surveys (DHS) from 57 countries conducted between 1999 and 2013. Our analyses focus on height-for-age z scores (HAZ) for children under 5 years of age who were surveyed as part of the DHS. To identify the causal effect of minimum wages, we utilized plausibly exogenous variation in the legislated minimum wages during each child's year of birth, the identifying assumption being that mothers do not time their births around changes in the minimum wage. As a sensitivity exercise, we also made within family comparisons (mother fixed effect models). Our final analysis on 49 countries reveal that a 1% increase in minimum wages was associated with 0.1% (95% CI = -0.2, 0) decrease in HAZ scores. Adverse effects of an increase in the minimum wage were observed among girls and for children of fathers who were less than 35 years old, mothers aged 20-29, parents who were married, parents who were less educated, and parents involved in manual work. We also explored heterogeneity by region and GDP per capita at baseline (1999). Adverse effects were concentrated in lower-income countries and were most pronounced in South Asia. By contrast, increases in the minimum wage improved children's HAZ in Latin America, and among children of parents working in a skilled sector. Our findings are inconsistent with the hypothesis that increases in the minimum wage unconditionally improve child health in lower-income countries, and highlight heterogeneity in the impact of minimum wages around the globe. Future work should involve country and occupation specific studies which can explore not only different outcomes such as infant mortality rates, but also explore the role of parental investments in shaping these effects. Copyright © 2016 Elsevier Ltd. All rights reserved.

Generation, propagation and run-up of tsunamis due to the Chicxulub impact event

NASA Astrophysics Data System (ADS)

Weisz, R.; Wuennenmann, K.; Bahlburg, H.

2003-04-01

The Chicxulub impact event can be investigated in (1) local, (2) regional and in (3) global scales. Our investigations focus on the regional scale, especially on the influence of tsunami waves on the coast around the Gulf of Mexico caused by the impact. During an impact two types of tsunamis are generated. The first wave is known as the "rim wave" and is generated in front of the ejecta curtain. The second one is linked to the late modification stage of the impact and results from the collapsing cavity of water. We designate this wave as "collapse wave". The "rim wave" and "collapse wave" are able to propagate over long distances, without a significant loss of wave amplitude. Corresponding to the amplitudes, the waves have a potentially large influence on the coastal areas. Run-up distance and run-up height can be used as parameters for describing this influence. We are utilizing a multimaterial hydrocode (SALE) to simulate the generation of tsunami waves. The propagation of the waves is based on the non-linear shallow water theory, because tsunami waves are defined to be long waves. The position of the coast line varies according to the tsunami run-up and is implemented with open boundary conditions. We show with our investigations (1) the generation of tsunami waves due to shallow water impacts, (2) wave damping during propagation, and (3) the influence of the "rim wave" and the "collapse wave" on the coastal areas. Here, we present our first results from numerical modeling of tsunami waves owing to a Chicxulub sized impactor. The characteristics of the “rim wave” depend on the size of the bolide and the water depth. However, the amplitude and velocity of the “collapse wave” is only determined by the water depth in the impact area. The numerical modeling of the tsunami propagation and run-up is calculated along a section from the impact point towards to the west and gives the moderate damping of both waves and the run-up on the coastal area. As a first

Gender Bias in Early Childhood Education.

ERIC Educational Resources Information Center

Kovar, Patricia McAfee; Doty, LuEllen

Noting that both boys and girls suffer because of gender bias in society and in the classroom, this paper examines the roots and consequences of such bias. The paper first provides a historical overview of gender bias and its relation to the prevalent world view. Next, it examines the manifestations of gender bias in the classroom and their…

Becoming a better person: temporal remoteness biases autobiographical memories for moral events

PubMed Central

Escobedo, Jessica R.; Adolphs, Ralph

2010-01-01

Our autobiographical self depends on the differential recollection of our personal past, notably including memories of morally laden events. While both emotion and temporal recency are well known to influence memory, very little is known about how we remember moral events, and in particular about the distribution in time of memories for events that were blameworthy or praiseworthy. To investigate this issue in detail, we collected a novel database of 758 confidential, autobiographical narratives for personal moral events from 100 well-characterized healthy adults. Negatively valenced moral memories were significantly more remote than positively valenced memories, both as measured by the valence of the cue word that evoked the memory as well as by the content of the memory itself. The effect was independent of chronological age, ethnicity, gender, or personality, arguing for a general emotional bias in how we construct our moral autobiography. PMID:20677868

Bias correction of risk estimates in vaccine safety studies with rare adverse events using a self-controlled case series design.

PubMed

Zeng, Chan; Newcomer, Sophia R; Glanz, Jason M; Shoup, Jo Ann; Daley, Matthew F; Hambidge, Simon J; Xu, Stanley

2013-12-15

The self-controlled case series (SCCS) method is often used to examine the temporal association between vaccination and adverse events using only data from patients who experienced such events. Conditional Poisson regression models are used to estimate incidence rate ratios, and these models perform well with large or medium-sized case samples. However, in some vaccine safety studies, the adverse events studied are rare and the maximum likelihood estimates may be biased. Several bias correction methods have been examined in case-control studies using conditional logistic regression, but none of these methods have been evaluated in studies using the SCCS design. In this study, we used simulations to evaluate 2 bias correction approaches-the Firth penalized maximum likelihood method and Cordeiro and McCullagh's bias reduction after maximum likelihood estimation-with small sample sizes in studies using the SCCS design. The simulations showed that the bias under the SCCS design with a small number of cases can be large and is also sensitive to a short risk period. The Firth correction method provides finite and less biased estimates than the maximum likelihood method and Cordeiro and McCullagh's method. However, limitations still exist when the risk period in the SCCS design is short relative to the entire observation period.

A Phenomenological Case Study: Teacher Bias Effects on Early Education Assessments

ERIC Educational Resources Information Center

Reynolds, Rebecca Jeannine

2012-01-01

This qualitative phenomenological case study explored the lived experiences of a purposive sample of 20 current and past early education teachers who have experience in assessing children through observational assessment. The purpose of this study was to determine if bias affects the documentation of observational assessment and the implementation…

Preference for language in early infancy: the human language bias is not speech specific.

PubMed

Krentz, Ursula C; Corina, David P

2008-01-01

Fundamental to infants' acquisition of their native language is an inherent interest in the language spoken around them over non-linguistic environmental sounds. The following studies explored whether the bias for linguistic signals in hearing infants is specific to speech, or reflects a general bias for all human language, spoken and signed. Results indicate that 6-month-old infants prefer an unfamiliar, visual-gestural language (American Sign Language) over non-linguistic pantomime, but 10-month-olds do not. These data provide evidence against a speech-specific bias in early infancy and provide insights into those properties of human languages that may underlie this language-general attentional bias.

[The effects of interpretation bias for social events and automatic thoughts on social anxiety].

PubMed

Aizawa, Naoki

2015-08-01

Many studies have demonstrated that individuals with social anxiety interpret ambiguous social situations negatively. It is, however, not clear whether the interpretation bias discriminatively contributes to social anxiety in comparison with depressive automatic thoughts. The present study investigated the effects of negative interpretation bias and automatic thoughts on social anxiety. The Social Intent Interpretation-Questionnaire, which measures the tendency to interpret ambiguous social events as implying other's rejective intents, the short Japanese version of the Automatic Thoughts Questionnaire-Revised, and the Anthropophobic Tendency Scale were administered to 317 university students. Covariance structure analysis indicated that both rejective intent interpretation bias and negative automatic thoughts contributed to mental distress in social situations mediated by a sense of powerlessness and excessive concern about self and others in social situations. Positive automatic thoughts reduced mental distress. These results indicate the importance of interpretation bias and negative automatic thoughts in the development and maintenance of social anxiety. Implications for understanding of the cognitive features of social anxiety were discussed.

Early life stress explains reduced positive memory biases in remitted depression.

PubMed

Gethin, J A; Lythe, K E; Workman, C I; Mayes, A; Moll, J; Zahn, R

2017-09-01

There is contradictory evidence regarding negative memory biases in major depressive disorder (MDD) and whether these persist into remission, which would suggest their role as vulnerability traits rather than correlates of mood state. Early life stress (ELS), common in patients with psychiatric disorders, has independently been associated with memory biases, and confounds MDD versus control group comparisons. Furthermore, in most studies negative biases could have resulted from executive impairments rather than memory difficulties per se. To investigate whether memory biases are relevant to MDD vulnerability and how they are influenced by ELS, we developed an associative recognition memory task for temporo-spatial contexts of social actions with low executive demands, which were matched across conditions (self-blame, other-blame, self-praise, other-praise). We included fifty-three medication-free remitted MDD (25 with ELS, 28 without) and 24 healthy control (HC) participants without ELS. Only MDD patients with ELS showed a reduced bias (accuracy/speed ratio) towards memory for positive vs. negative materials when compared with MDD without ELS and with HC participants; attenuated positive biases correlated with number of past major depressive episodes, but not current symptoms. There were no biases towards self-blaming or self-praising memories. This demonstrates that reduced positive biases in associative memory were specific to MDD patients with ELS rather than a general feature of MDD, and were associated with lifetime recurrence risk which may reflect a scarring effect. If replicated, our results would call for stratifying MDD patients by history of ELS when assessing and treating emotional memories. Copyright © 2017 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Aftermath of early Hit-and-Run collisions in the Inner Solar System

NASA Astrophysics Data System (ADS)

Sarid, Gal; Stewart, Sarah T.; Leinhardt, zoe M.

2015-08-01

Planet formation epoch, in the terrestrial planet region and the asteroid belt, was characterized by a vigorous dynamical environment that was conducive to giant impacts among planetary embryos and asteroidal parent bodies, leading to diverse outcomes. Among these the greatest potential for producing diverse end-members lies is the erosive Hit-and-Run regime (small mass ratios, off-axis oblique impacts and non-negligible ejected mass), which is also more probable in terms of the early dynamical encounter configuration in the inner solar system. This collision regime has been invoked to explain outstanding issues, such as planetary volatile loss records, origin of the Moon and mantle stripping from Mercury and some of the larger asteroids (Vesta, Psyche).We performed and analyzed a set of simulations of Hit-and-Run events, covering a large range of mass ratios (1-20), impact parameters (0.25-0.96, for near head-on to barely grazing) and impact velocities (~1.5-5 times the mutual escape velocity, as dependent on the mass ratio). We used an SPH code with tabulated EOS and a nominal simlated time >1 day, to track the collisional shock processing and the provenance of material components. of collision debris. Prior to impact runs, all bodies were allowed to initially settle to negligible particle velocities in isolation, within ~20 simulated hrs. The total number of particles involved in each of our collision simulations was between (1-3 x 105). Resulting configurations include stripped mantles, melting/vaporization of rock and/or iron cores and strong variations of asteroid parent bodies fromcanonical chondritic composition.In the context of large planetary formation simulations, velocity and impact angle distributions are necessary to asses impact probabilities. The mass distribution and interaction within planetary embryo and asteroid swarms depends both on gravitational dynamics and the applied fragmentation mechanism. We will present results pertaining to general

About neighborhood counting measure metric and minimum risk metric.

PubMed

Argentini, Andrea; Blanzieri, Enrico

2010-04-01

In a 2006 TPAMI paper, Wang proposed the Neighborhood Counting Measure, a similarity measure for the k-NN algorithm. In his paper, Wang mentioned the Minimum Risk Metric (MRM), an early distance measure based on the minimization of the risk of misclassification. Wang did not compare NCM to MRM because of its allegedly excessive computational load. In this comment paper, we complete the comparison that was missing in Wang's paper and, from our empirical evaluation, we show that MRM outperforms NCM and that its running time is not prohibitive as Wang suggested.

Changes in Visual Object Recognition Precede the Shape Bias in Early Noun Learning

PubMed Central

Yee, Meagan; Jones, Susan S.; Smith, Linda B.

2012-01-01

Two of the most formidable skills that characterize human beings are language and our prowess in visual object recognition. They may also be developmentally intertwined. Two experiments, a large sample cross-sectional study and a smaller sample 6-month longitudinal study of 18- to 24-month-olds, tested a hypothesized developmental link between changes in visual object representation and noun learning. Previous findings in visual object recognition indicate that children’s ability to recognize common basic level categories from sparse structural shape representations of object shape emerges between the ages of 18 and 24 months, is related to noun vocabulary size, and is lacking in children with language delay. Other research shows in artificial noun learning tasks that during this same developmental period, young children systematically generalize object names by shape, that this shape bias predicts future noun learning, and is lacking in children with language delay. The two experiments examine the developmental relation between visual object recognition and the shape bias for the first time. The results show that developmental changes in visual object recognition systematically precede the emergence of the shape bias. The results suggest a developmental pathway in which early changes in visual object recognition that are themselves linked to category learning enable the discovery of higher-order regularities in category structure and thus the shape bias in novel noun learning tasks. The proposed developmental pathway has implications for understanding the role of specific experience in the development of both visual object recognition and the shape bias in early noun learning. PMID:23227015

Developmental Differences in the Effects of Repeated Interviews and Interviewer Bias on Young Children’s Event Memory and False Reports

PubMed Central

Quas, Jodi A.; Malloy, Lindsay C.; Melinder, Annika; Goodman, Gail S.; D’Mello, Michelle; Schaaf, Jennifer

2010-01-01

The present study investigated developmental differences in the effects of repeated interviews and interviewer bias on children’s memory and suggestibility. Three- and 5-year-olds were singly or repeatedly interviewed about a play event by a highly biased or control interviewer. Children interviewed once by the biased interviewer after a long delay made the most errors. Children interviewed repeatedly, regardless of interviewer bias, were more accurate and less likely to falsely claim that they played with a man. In free recall, among children questioned once after a long delay by the biased interviewer, 5-year-olds were more likely than were 3-year-olds to claim falsely that they played with a man. However, in response to direct questions, 3-year-olds were more easily manipulated into implying that they played with him. Findings suggest that interviewer bias is particularly problematic when children’s memory has weakened. In contrast, repeated interviews that occur a short time after a to-be-remembered event do not necessarily increase children’s errors, even when interviews include misleading questions and interviewer bias. Implications for developmental differences in memory and suggestibility are discussed. PMID:17605517

Hyperdynamics boost factor achievable with an ideal bias potential

DOE PAGES

Huang, Chen; Perez, Danny; Voter, Arthur F.

2015-08-20

Hyperdynamics is a powerful method to significantly extend the time scales amenable to molecular dynamics simulation of infrequent events. One outstanding challenge, however, is the development of the so-called bias potential required by the method. In this work, we design a bias potential using information about all minimum energy pathways (MEPs) out of the current state. While this approach is not suitable for use in an actual hyperdynamics simulation, because the pathways are generally not known in advance, it allows us to show that it is possible to come very close to the theoretical boost limit of hyperdynamics while maintainingmore » high accuracy. We demonstrate this by applying this MEP-based hyperdynamics (MEP-HD) to metallic surface diffusion systems. In most cases, MEP-HD gives boost factors that are orders of magnitude larger than the best existing bias potential, indicating that further development of hyperdynamics bias potentials could have a significant payoff. Lastly, we discuss potential practical uses of MEP-HD, including the possibility of developing MEP-HD into a true hyperdynamics.« less

Threatening events theme of cognitive biases mediates the relationship between fear of social situations and delusion-like experiences among healthy adults.

PubMed

Prochwicz, Katarzyna; Kłosowska, Joanna; Karpowska, Milena

2017-10-01

Social anxiety (SA) is frequently observed among patients diagnosed with psychosis as well as among individuals with delusion-like experiences (DLEs). A heightened level of SA has been recognized to precede the development of psychotic symptoms; however, the detailed mechanisms that link SA to delusional ideation remain unrecognized. Since social anxiety is associated with the presence of cognitive biases and biased cognitive processes have been found to play a role in the development and maintenance of delusions, we hypothesized that cognitive biases may mediate in the relationship between social anxiety and DLEs. A total sample of 202 healthy individuals with mean age 35.59 (SD = 17.15) was assessed for the presence of delusion-like experiences, social anxiety, as well as the threatening events theme and anomalous perception theme of cognitive biases. The threatening events theme was found to fully mediate the linkage between fear of social situations and DLEs (β = 0.12, p < 0.05). The threatening events theme was also found to be a partial mediator in the association between social avoidance and DLEs (β = 0.20, p < 0.05), and between the overall level of social anxiety and DLEs (β = 0.18, p < 0.05). Our findings suggest that social anxiety may influence DLEs by providing the threatening events theme of cognitive biases. Copyright © 2017 Elsevier B.V. All rights reserved.

Quantile-based bias correction and uncertainty quantification of extreme event attribution statements

DOE PAGES

Jeon, Soyoung; Paciorek, Christopher J.; Wehner, Michael F.

2016-02-16

Extreme event attribution characterizes how anthropogenic climate change may have influenced the probability and magnitude of selected individual extreme weather and climate events. Attribution statements often involve quantification of the fraction of attributable risk (FAR) or the risk ratio (RR) and associated confidence intervals. Many such analyses use climate model output to characterize extreme event behavior with and without anthropogenic influence. However, such climate models may have biases in their representation of extreme events. To account for discrepancies in the probabilities of extreme events between observational datasets and model datasets, we demonstrate an appropriate rescaling of the model output basedmore » on the quantiles of the datasets to estimate an adjusted risk ratio. Our methodology accounts for various components of uncertainty in estimation of the risk ratio. In particular, we present an approach to construct a one-sided confidence interval on the lower bound of the risk ratio when the estimated risk ratio is infinity. We demonstrate the methodology using the summer 2011 central US heatwave and output from the Community Earth System Model. In this example, we find that the lower bound of the risk ratio is relatively insensitive to the magnitude and probability of the actual event.« less

Face race processing and racial bias in early development: A perceptual-social linkage.

PubMed

Lee, Kang; Quinn, Paul C; Pascalis, Olivier

2017-06-01

Infants have asymmetrical exposure to different types of faces (e.g., more human than other-species, more female than male, and more own-race than other-race). What are the developmental consequences of such experiential asymmetry? Here we review recent advances in research on the development of cross-race face processing. The evidence suggests that greater exposure to own- than other-race faces in infancy leads to developmentally early perceptual differences in visual preference, recognition, category formation, and scanning of own- and other-race faces. Further, such perceptual differences in infancy may be associated with the emergence of implicit racial bias, consistent with a Perceptual-Social Linkage Hypothesis. Current and future work derived from this hypothesis may lay an important empirical foundation for the development of intervention programs to combat the early occurrence of implicit racial bias.

A New Observation Technique Applied to Early/Fast VLF Scattering Events

NASA Astrophysics Data System (ADS)

Kotovsky, D. A.; Moore, R. C.

2012-12-01

Early/fast very low frequency (VLF, 3-30 kHz) events are understood to result from ionospheric conductivity changes associated with lightning. Early/fast amplitude and phase perturbations have been observed coincidentally with various optical observations of transient luminous events (TLEs), including elves, sprites, and sprite halos, each of which can have temporal characteristics consistent with those of early/fast VLF events. It is yet unresolved, however, whether a specific type of TLE is directly related to the ionospheric conductivity changes responsible for the typical early/fast event. In this paper, we present spread spectrum VLF scattering observations of early/fast events. The spread spectrum analysis technique determines the amplitude and phase of a subionospherically propagating VLF signal as a function of time during the early/fast event and as a function of frequency across the 200 Hz bandwidth of the VLF transmission. VLF scattering observations, each identified with causative lightning logged by the National Lightning Detection Network (NLDN), are compared with the predictions of the Long-Wave Propagation Capability (LWPC) code, a three-dimensional earth-ionosphere waveguide propagation and scattering model. Theoretical predictions for VLF scattering from ionization changes associated with elves are compared with those associated with sprite halos, and each are compared with experimental observations. Results indicate that the observed frequency dependence of VLF scattering during early/fast events results from the combination of scattering source properties and Earth-ionosphere waveguide propagation effects. Observations are more consistent with the modeled amplitude perturbations associated with sprite halos than those with elves.

Calibration and performance of the ATLAS Tile Calorimeter during the LHC Run 2

NASA Astrophysics Data System (ADS)

Cerda Alberich, L.

2018-02-01

The Tile Calorimeter (TileCal) is the hadronic sampling calorimeter of the ATLAS experiment at the Large Hadron Collider (LHC). TileCal uses iron absorbers and scintillators as active material and it covers the central region | η| < 1.7. Jointly with the other sub-detectors it is designed for measurements of hadrons, jets, tau-particles and missing transverse energy. It also assists in muon identification. TileCal is regularly monitored and calibrated by several different calibration systems: a Cs radioactive source, a laser light system to check the PMT response, and a charge injection system (CIS) to check the front-end electronics. These calibration systems, in conjunction with data collected during proton-proton collisions, Minimum Bias (MB) events, provide extensive monitoring of the instrument and a means for equalizing the calorimeter response at each stage of the signal propagation. The performance of the calorimeter has been established with cosmic ray muons and the large sample of the proton-proton collisions and compared to Monte Carlo (MC) simulations. The response of high momentum isolated muons is also used to study the energy response at the electromagnetic scale, isolated hadrons are used as a probe of the hadronic response. The calorimeter time resolution is studied with multijet events. A description of the different TileCal calibration systems and the results on the calorimeter performance during the LHC Run 2 are presented. The results on the pile-up noise and response uniformity studies are also discussed.

A method for modeling bias in a person's estimates of likelihoods of events

NASA Technical Reports Server (NTRS)

Nygren, Thomas E.; Morera, Osvaldo

1988-01-01

It is of practical importance in decision situations involving risk to train individuals to transform uncertainties into subjective probability estimates that are both accurate and unbiased. We have found that in decision situations involving risk, people often introduce subjective bias in their estimation of the likelihoods of events depending on whether the possible outcomes are perceived as being good or bad. Until now, however, the successful measurement of individual differences in the magnitude of such biases has not been attempted. In this paper we illustrate a modification of a procedure originally outlined by Davidson, Suppes, and Siegel (3) to allow for a quantitatively-based methodology for simultaneously estimating an individual's subjective utility and subjective probability functions. The procedure is now an interactive computer-based algorithm, DSS, that allows for the measurement of biases in probability estimation by obtaining independent measures of two subjective probability functions (S+ and S-) for winning (i.e., good outcomes) and for losing (i.e., bad outcomes) respectively for each individual, and for different experimental conditions within individuals. The algorithm and some recent empirical data are described.

Early Family System Types Predict Children's Emotional Attention Biases at School Age

ERIC Educational Resources Information Center

Lindblom, Jallu; Peltola, Mikko J.; Vänskä, Mervi; Hietanen, Jari K.; Laakso, Anu; Tiitinen, Aila; Tulppala, Maija; Punamäki, Raija-Leena

2017-01-01

The family environment shapes children's social information processing and emotion regulation. Yet, the long-term effects of early family systems have rarely been studied. This study investigated how family system types predict children's attentional biases toward facial expressions at the age of 10 years. The participants were 79 children from…

Negative life events of anxiety disordered children: bad fortune, vulnerability, or reporter bias?

PubMed

Boer, Frits; Markus, Monica T; Maingay, Ragna; Lindhout, Ingeborg E; Borst, Sophie R; Hoogendijk, Thea H G

2002-01-01

This article seeks to examine the nature of negative life events of anxiety-disordered children: to what extent are they unique, to what extent are they shared with siblings, and when they are shared, is the impact similar or different? Twenty-five anxiety-disordered children aged 8 to 13 years, referred to a child psychiatric clinic, were compared with matched non-clinical controls, and with their nearest in age nonreferred sibling aged 6 to 13 years on the number of parent-reported stressful life events. Anxiety-disordered children differ significantly from well controls in the number of negative life events reported by their parents over their lifetime, and the year preceding referral. Anxiety disordered children also differ significantly from their non-referred nearest in age sibling in the number of negative life events, both non-shared and shared. The difference in shared events is due to differences in appraisal by the parents of the impact of a shared event on the respective children. The often reported finding that children with anxiety disorders have experienced more negative life events than their healthy peers is partially due to objective differences in the occurrence of these events, but may also reflect heightened vulnerability or reporter bias.

Intermittent regime of brain activity at the early, bias-guided stage of perceptual learning.

PubMed

Nikolaev, Andrey R; Gepshtein, Sergei; van Leeuwen, Cees

2016-11-01

Perceptual learning improves visual performance. Among the plausible mechanisms of learning, reduction of perceptual bias has been studied the least. Perceptual bias may compensate for lack of stimulus information, but excessive reliance on bias diminishes visual discriminability. We investigated the time course of bias in a perceptual grouping task and studied the associated cortical dynamics in spontaneous and evoked EEG. Participants reported the perceived orientation of dot groupings in ambiguous dot lattices. Performance improved over a 1-hr period as indicated by the proportion of trials in which participants preferred dot groupings favored by dot proximity. The proximity-based responses were compromised by perceptual bias: Vertical groupings were sometimes preferred to horizontal ones, independent of dot proximity. In the evoked EEG activity, greater amplitude of the N1 component for horizontal than vertical responses indicated that the bias was most prominent in conditions of reduced visual discriminability. The prominence of bias decreased in the course of the experiment. Although the bias was still prominent, prestimulus activity was characterized by an intermittent regime of alternating modes of low and high alpha power. Responses were more biased in the former mode, indicating that perceptual bias was deployed actively to compensate for stimulus uncertainty. Thus, early stages of perceptual learning were characterized by episodes of greater reliance on prior visual preferences, alternating with episodes of receptivity to stimulus information. In the course of learning, the former episodes disappeared, and biases reappeared only infrequently.

Operational early warning platform for extreme meteorological events

NASA Astrophysics Data System (ADS)

Mühr, Bernhard; Kunz, Michael

2015-04-01

Operational early warning platform for extreme meteorological events Most natural disasters are related to extreme weather events (e.g. typhoons); weather conditions, however, are also highly relevant for humanitarian and disaster relief operations during and after other natural disaster like earthquakes. The internet service "Wettergefahren-Frühwarnung" (WF) provides various information on extreme weather events, especially when these events are associated with a high potential for large damage. The main focus of the platform is on Central Europe, but major events are also monitored worldwide on a daily routine. WF provides high-resolution forecast maps for many weather parameters which allow detailed and reliable predictions about weather conditions during the next days in the affected areas. The WF service became operational in February 2004 and is part of the Center for Disaster Management and Risk Reduction Technology (CEDIM) since 2007. At the end of 2011, CEDIM embarked a new type of interdisciplinary disaster research termed as forensic disaster analysis (FDA) in near real time. In case of an imminent extreme weather event WF plays an important role in CEDIM's FDA group. It provides early and precise information which are always available and updated several times during a day and gives advice and assists with articles and reports on extreme events.

Run-up of Tsunamis in the Gulf of Mexico caused by the Chicxulub Impact Event

NASA Astrophysics Data System (ADS)

Weisz, R.; Wünnenmann, K.; Bahlburg, H.

2003-04-01

The Chicxulub impact event can be investigated on (1) local, (2) regional and in (3) global scales. Our investigations focus on the regional scale, especially on the run-up of tsunami waves on the coast around the Gulf of Mexico caused by the impact. An impact produces two types of tsunami waves: (1) the rim wave, (2) the collapse wave. Both waves propagate over long distances and reach coastal areas. Depending on the tsunami wave characteristics, they have a potentionally large influence on the coastal areas. Run-up distance and run-up height can be used as parameters for assessing this influence. To calculate these parameters, we are using a multi-material hydrocode (SALE) to simulate the generation of the tsunami wave, a non-linear shallow water approach for the propagation, and we implemented a special open boundary for considering the run-up of tsunami waves. With the help of the one-dimensional shallow water approach, we will give run-up heights and distances for the coastal area around the Gulf of Mexico. The calculations are done along several sections from the impact site towards the coast. These are a first approximation to run-up calculations for the entire coast of the Gulf of Mexico. The bathymetric data along the sections, used in the wave propagation and run-up, correspond to a linearized bathymetry of the recent Gulf of Mexico. Additionally, we will present preliminary results from our first two-dimensional experiments of propagation and run-up. These results will be compared with the one-dimensional approach.

Interpretation Bias Modification for Youth and their Parents: A Novel Treatment for Early Adolescent Social Anxiety

PubMed Central

Reuland, Meg M.; Teachman, Bethany A.

2014-01-01

Social anxiety is the most prevalent anxiety disorder of late adolescence, yet current treatments reach only a minority of youth with the disorder. Effective and easy-to-disseminate treatments are needed. This study pilot tested the efficacy of a novel, online cognitive bias modification for interpretation (CBM-I) intervention for socially anxious youth and their parents. The CBM-I intervention targeted cognitive biases associated with early adolescents’ maladaptive beliefs regarding social situations, and with parents’ intrusive behavior, both of which have been theoretically linked with the maintenance of social anxiety in youth. To investigate the efficacy of intervening with parents and/or children, clinically diagnosed early adolescents (ages 10–15; N = 18) and their mothers were randomly assigned to one of three conditions: the first targeted early adolescents’ cognitive biases related to social anxiety (Child-only condition); the second targeted parents’ biases associated with intrusive behavior (Parent-only condition); and the third targeted both youth and parents’ biases in tandem (Combo condition). The use of a multiple baseline design allowed for the efficient assessment of causal links between the intervention and reduction in social anxiety symptoms in youth. Results provided converging evidence indicating modest support for the efficacy of CBM-I, with no reliable differences across conditions. Taken together, results suggest that online CBM-I with anxious youth and/or their parents holds promise as an effective and easily administered component of treatment for child social anxiety that deserves further evaluation in a larger trial. PMID:25445075

Interpretation bias modification for youth and their parents: a novel treatment for early adolescent social anxiety.

PubMed

Reuland, Meg M; Teachman, Bethany A

2014-12-01

Social anxiety is the most prevalent anxiety disorder of late adolescence, yet current treatments reach only a minority of youth with the disorder. Effective and easy-to-disseminate treatments are needed. This study pilot tested the efficacy of a novel, online cognitive bias modification for interpretation (CBM-I) intervention for socially anxious youth and their parents. The CBM-I intervention targeted cognitive biases associated with early adolescents' maladaptive beliefs regarding social situations, and with parents' intrusive behavior, both of which have been theoretically linked with the maintenance of social anxiety in youth. To investigate the efficacy of intervening with parents and/or children, clinically diagnosed early adolescents (ages 10-15; N=18) and their mothers were randomly assigned to one of three conditions: the first targeted early adolescents' cognitive biases related to social anxiety (Child-only condition); the second targeted parents' biases associated with intrusive behavior (Parent-only condition); and the third targeted both youth and parents' biases in tandem (Combo condition). The use of a multiple baseline design allowed for the efficient assessment of causal links between the intervention and reduction in social anxiety symptoms in youth. Results provided converging evidence indicating modest support for the efficacy of CBM-I, with no reliable differences across conditions. Taken together, results suggest that online CBM-I with anxious youth and/or their parents holds promise as an effective and easily administered component of treatment for child social anxiety that deserves further evaluation in a larger trial. Copyright © 2014 Elsevier Ltd. All rights reserved.

25 CFR 547.10 - What are the minimum standards for Class II gaming system critical events?

Code of Federal Regulations, 2010 CFR

2010-04-01

... GAMES § 547.10 What are the minimum standards for Class II gaming system critical events? This section... be considered reliable. Accordingly, any game play on the affected component shall cease immediately... has some fault.Any game play on the affected component shall cease immediately, and an appropriate...

Not Only Size Matters: Early-Talker and Late-Talker Vocabularies Support Different Word-Learning Biases in Babies and Networks.

PubMed

Colunga, Eliana; Sims, Clare E

2017-02-01

In typical development, word learning goes from slow and laborious to fast and seemingly effortless. Typically developing 2-year-olds seem to intuit the whole range of things in a category from hearing a single instance named-they have word-learning biases. This is not the case for children with relatively small vocabularies (late talkers). We present a computational model that accounts for the emergence of word-learning biases in children at both ends of the vocabulary spectrum based solely on vocabulary structure. The results of Experiment 1 show that late-talkers' and early-talkers' noun vocabularies have different structures and that neural networks trained on the vocabularies of individual late talkers acquire different word-learning biases than those trained on early-talker vocabularies. These models make novel predictions about the word-learning biases in these two populations. Experiment 2 tests these predictions on late- and early-talking toddlers in a novel noun generalization task. Copyright © 2016 Cognitive Science Society, Inc.

Early Cambrian oxygen minimum zone-like conditions at Chengjiang

NASA Astrophysics Data System (ADS)

Hammarlund, Emma U.; Gaines, Robert R.; Prokopenko, Maria G.; Qi, Changshi; Hou, Xian-Guang; Canfield, Donald E.

2017-10-01

The early Cambrian succession at Chengjiang contains the most diverse Cambrian fossil assemblage yet described, and contributes significantly to our understanding of the diversification of metazoans in the Cambrian ;explosion;. The Cambrian Period occupies a transitional episode of global ocean chemistry, following the oxygenation of the surface ocean and of shallow marine environments during the Ediacaran Period, but prior to the establishment of a predominantly oxygenated deep ocean in the mid-Paleozoic. Despite recent attention, a detailed understanding of the chemical conditions that prevailed in early Cambrian marine settings and the relationship of those conditions to early metazoan ecosystems is still emerging. Here, we report multi-proxy geochemical data from two drill cores through the early Cambrian (Series 2) Yu'anshan Formation of Yunnan, China. Results reveal dynamic water-column chemistry within the succession, which progressively shifted from euxinic to oxic conditions during deposition of the Yu'anshan Formation. The Chengjiang biota occurs in strata that appear to have been deposited under an oxygen-depleted water column that may have supported denitrification, as in modern oxygen-minimum zones. The oxygenated benthic environments in which the Chengjiang biota thrived were proximal to, but sharply separated from, the open ocean by a persistent anoxic water mass that occupied a portion of the outer shelf. Oxygen depletion in the lower water column developed dynamically in response to nutrient availability and possibly at lower thresholds of productivity due to lower atmospheric oxygen concentrations in Cambrian. These findings suggest that the frequent development of oxygen-limiting conditions in continental margin settings provided an environmental barrier that may have affected biogeographic, ecological and evolutionary development of early metazoan communities.

Search strategy using LHC pileup interactions as a zero bias sample

NASA Astrophysics Data System (ADS)

Nachman, Benjamin; Rubbo, Francesco

2018-05-01

Due to a limited bandwidth and a large proton-proton interaction cross section relative to the rate of interesting physics processes, most events produced at the Large Hadron Collider (LHC) are discarded in real time. A sophisticated trigger system must quickly decide which events should be kept and is very efficient for a broad range of processes. However, there are many processes that cannot be accommodated by this trigger system. Furthermore, there may be models of physics beyond the standard model (BSM) constructed after data taking that could have been triggered, but no trigger was implemented at run time. Both of these cases can be covered by exploiting pileup interactions as an effective zero bias sample. At the end of high-luminosity LHC operations, this zero bias dataset will have accumulated about 1 fb-1 of data from which a bottom line cross section limit of O (1 ) fb can be set for BSM models already in the literature and those yet to come.

Adaptively biased sequential importance sampling for rare events in reaction networks with comparison to exact solutions from finite buffer dCME method

PubMed Central

Cao, Youfang; Liang, Jie

2013-01-01

Critical events that occur rarely in biological processes are of great importance, but are challenging to study using Monte Carlo simulation. By introducing biases to reaction selection and reaction rates, weighted stochastic simulation algorithms based on importance sampling allow rare events to be sampled more effectively. However, existing methods do not address the important issue of barrier crossing, which often arises from multistable networks and systems with complex probability landscape. In addition, the proliferation of parameters and the associated computing cost pose significant problems. Here we introduce a general theoretical framework for obtaining optimized biases in sampling individual reactions for estimating probabilities of rare events. We further describe a practical algorithm called adaptively biased sequential importance sampling (ABSIS) method for efficient probability estimation. By adopting a look-ahead strategy and by enumerating short paths from the current state, we estimate the reaction-specific and state-specific forward and backward moving probabilities of the system, which are then used to bias reaction selections. The ABSIS algorithm can automatically detect barrier-crossing regions, and can adjust bias adaptively at different steps of the sampling process, with bias determined by the outcome of exhaustively generated short paths. In addition, there are only two bias parameters to be determined, regardless of the number of the reactions and the complexity of the network. We have applied the ABSIS method to four biochemical networks: the birth-death process, the reversible isomerization, the bistable Schlögl model, and the enzymatic futile cycle model. For comparison, we have also applied the finite buffer discrete chemical master equation (dCME) method recently developed to obtain exact numerical solutions of the underlying discrete chemical master equations of these problems. This allows us to assess sampling results objectively

Adaptively biased sequential importance sampling for rare events in reaction networks with comparison to exact solutions from finite buffer dCME method

NASA Astrophysics Data System (ADS)

Cao, Youfang; Liang, Jie

2013-07-01

Critical events that occur rarely in biological processes are of great importance, but are challenging to study using Monte Carlo simulation. By introducing biases to reaction selection and reaction rates, weighted stochastic simulation algorithms based on importance sampling allow rare events to be sampled more effectively. However, existing methods do not address the important issue of barrier crossing, which often arises from multistable networks and systems with complex probability landscape. In addition, the proliferation of parameters and the associated computing cost pose significant problems. Here we introduce a general theoretical framework for obtaining optimized biases in sampling individual reactions for estimating probabilities of rare events. We further describe a practical algorithm called adaptively biased sequential importance sampling (ABSIS) method for efficient probability estimation. By adopting a look-ahead strategy and by enumerating short paths from the current state, we estimate the reaction-specific and state-specific forward and backward moving probabilities of the system, which are then used to bias reaction selections. The ABSIS algorithm can automatically detect barrier-crossing regions, and can adjust bias adaptively at different steps of the sampling process, with bias determined by the outcome of exhaustively generated short paths. In addition, there are only two bias parameters to be determined, regardless of the number of the reactions and the complexity of the network. We have applied the ABSIS method to four biochemical networks: the birth-death process, the reversible isomerization, the bistable Schlögl model, and the enzymatic futile cycle model. For comparison, we have also applied the finite buffer discrete chemical master equation (dCME) method recently developed to obtain exact numerical solutions of the underlying discrete chemical master equations of these problems. This allows us to assess sampling results objectively

Adaptively biased sequential importance sampling for rare events in reaction networks with comparison to exact solutions from finite buffer dCME method.

PubMed

Cao, Youfang; Liang, Jie

2013-07-14

Critical events that occur rarely in biological processes are of great importance, but are challenging to study using Monte Carlo simulation. By introducing biases to reaction selection and reaction rates, weighted stochastic simulation algorithms based on importance sampling allow rare events to be sampled more effectively. However, existing methods do not address the important issue of barrier crossing, which often arises from multistable networks and systems with complex probability landscape. In addition, the proliferation of parameters and the associated computing cost pose significant problems. Here we introduce a general theoretical framework for obtaining optimized biases in sampling individual reactions for estimating probabilities of rare events. We further describe a practical algorithm called adaptively biased sequential importance sampling (ABSIS) method for efficient probability estimation. By adopting a look-ahead strategy and by enumerating short paths from the current state, we estimate the reaction-specific and state-specific forward and backward moving probabilities of the system, which are then used to bias reaction selections. The ABSIS algorithm can automatically detect barrier-crossing regions, and can adjust bias adaptively at different steps of the sampling process, with bias determined by the outcome of exhaustively generated short paths. In addition, there are only two bias parameters to be determined, regardless of the number of the reactions and the complexity of the network. We have applied the ABSIS method to four biochemical networks: the birth-death process, the reversible isomerization, the bistable Schlögl model, and the enzymatic futile cycle model. For comparison, we have also applied the finite buffer discrete chemical master equation (dCME) method recently developed to obtain exact numerical solutions of the underlying discrete chemical master equations of these problems. This allows us to assess sampling results objectively

Event generator tunes obtained from underlying event and multiparton scattering measurements.

PubMed

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Haitz, D; Hartmann, F; Heindl, S M; Husemann, U; Katkov, I; Kornmayer, A; Lobelle Pardo, P; Maier, B; Mildner, H; Mozer, M U; Müller, T; Müller, Th; Plagge, M; Quast, G; Rabbertz, K; Röcker, S; Roscher, F; Sieber, G; Simonis, H J; Stober, F M; Ulrich, R; Wagner-Kuhr, J; Wayand, S; Weber, M; Weiler, T; Williamson, S; Wöhrmann, C; Wolf, R; Anagnostou, G; Daskalakis, G; Geralis, T; Giakoumopoulou, V A; Kyriakis, A; Loukas, D; Psallidas, A; Topsis-Giotis, I; Agapitos, A; Kesisoglou, S; Panagiotou, A; Saoulidou, N; Tziaferi, E; Evangelou, I; Flouris, G; Foudas, C; Kokkas, P; Loukas, N; Manthos, N; Papadopoulos, I; Paradas, E; Strologas, J; Bencze, G; Hajdu, C; Hazi, A; Hidas, P; Horvath, D; Sikler, F; Veszpremi, V; Vesztergombi, G; Zsigmond, A J; Beni, N; Czellar, S; Karancsi, J; Molnar, J; Szillasi, Z; Bartók, M; Makovec, A; Raics, P; Trocsanyi, Z L; Ujvari, B; Mal, P; Mandal, K; Sahoo, D K; Sahoo, N; Swain, S K; Bansal, S; Beri, S B; Bhatnagar, V; Chawla, R; Gupta, R; Bhawandeep, U; Kalsi, A K; 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Salfeld-Nebgen, J; Stephans, G S F; Sumorok, K; Varma, M; Velicanu, D; Veverka, J; Wang, J; Wang, T W; Wyslouch, B; Yang, M; Zhukova, V; Dahmes, B; Evans, A; Finkel, A; Gude, A; Hansen, P; Kalafut, S; Kao, S C; Klapoetke, K; Kubota, Y; Lesko, Z; Mans, J; Nourbakhsh, S; Ruckstuhl, N; Rusack, R; Tambe, N; Turkewitz, J; Acosta, J G; Oliveros, S; Avdeeva, E; Bloom, K; Bose, S; Claes, D R; Dominguez, A; Fangmeier, C; Gonzalez Suarez, R; Kamalieddin, R; Keller, J; Knowlton, D; Kravchenko, I; Meier, F; Monroy, J; Ratnikov, F; Siado, J E; Snow, G R; Alyari, M; Dolen, J; George, J; Godshalk, A; Harrington, C; Iashvili, I; Kaisen, J; Kharchilava, A; Kumar, A; Rappoccio, S; Roozbahani, B; Alverson, G; Barberis, E; Baumgartel, D; Chasco, M; Hortiangtham, A; Massironi, A; Morse, D M; Nash, D; Orimoto, T; Teixeira De Lima, R; Trocino, D; Wang, R-J; Wood, D; Zhang, J; Hahn, K A; Kubik, A; Mucia, N; Odell, N; Pollack, B; Pozdnyakov, A; Schmitt, M; Stoynev, S; Sung, K; Trovato, M; Velasco, M; Brinkerhoff, A; Dev, N; Hildreth, M; Jessop, C; Karmgard, D J; Kellams, N; Lannon, K; Marinelli, N; Meng, F; Mueller, C; Musienko, Y; Planer, M; Reinsvold, A; Ruchti, R; Smith, G; Taroni, S; Valls, N; Wayne, M; Wolf, M; Woodard, A; Antonelli, L; Brinson, J; Bylsma, B; Durkin, L S; Flowers, S; Hart, A; Hill, C; Hughes, R; Ji, W; Ling, T Y; Liu, B; Luo, W; Puigh, D; Rodenburg, M; Winer, B L; Wulsin, H W; Driga, O; Elmer, P; Hardenbrook, J; Hebda, P; Koay, S A; Lujan, P; Marlow, D; Medvedeva, T; Mooney, M; Olsen, J; Palmer, C; Piroué, P; Saka, H; Stickland, D; Tully, C; Zuranski, A; Malik, S; Barnes, V E; Benedetti, D; Bortoletto, D; Gutay, L; Jha, M K; Jones, M; Jung, K; Miller, D H; Neumeister, N; Primavera, F; Radburn-Smith, B C; Shi, X; Shipsey, I; Silvers, D; Sun, J; Svyatkovskiy, A; Wang, F; Xie, W; Xu, L; Parashar, N; Stupak, J; Adair, A; Akgun, B; Chen, Z; Ecklund, K M; Geurts, F J M; Guilbaud, M; Li, W; Michlin, B; Northup, M; Padley, B P; Redjimi, R; Roberts, J; Rorie, J; Tu, Z; Zabel, J; Betchart, B; Bodek, A; de Barbaro, P; Demina, R; Eshaq, Y; Ferbel, T; Galanti, M; Galanti, M; Garcia-Bellido, A; Han, J; Harel, A; Hindrichs, O; Hindrichs, O; Khukhunaishvili, A; Petrillo, G; Tan, P; Verzetti, M; Arora, S; Barker, A; Chou, J P; Contreras-Campana, C; Contreras-Campana, E; Ferencek, D; Gershtein, Y; Gray, R; Halkiadakis, E; Hidas, D; Hughes, E; Kaplan, S; Kunnawalkam Elayavalli, R; Lath, A; Nash, K; Panwalkar, S; Park, M; Salur, S; Schnetzer, S; Sheffield, D; Somalwar, S; Stone, R; Thomas, S; Thomassen, P; Walker, M; Foerster, M; Riley, G; Rose, K; Spanier, S; York, A; Bouhali, O; Castaneda Hernandez, A; Celik, A; Dalchenko, M; De Mattia, M; Delgado, A; Dildick, S; Dildick, S; Eusebi, R; Gilmore, J; Huang, T; Kamon, T; Krutelyov, V; Krutelyov, V; Mueller, R; Osipenkov, I; Pakhotin, Y; Patel, R; Patel, R; Perloff, A; Rose, A; Safonov, A; Tatarinov, A; Ulmer, K A; Akchurin, N; Cowden, C; Damgov, J; Dragoiu, C; Dudero, P R; Faulkner, J; Kunori, S; Lamichhane, K; Lee, S W; Libeiro, T; Undleeb, S; Volobouev, I; Appelt, E; Delannoy, A G; Greene, S; Gurrola, A; Janjam, R; Johns, W; Maguire, C; Mao, Y; Melo, A; Ni, H; Sheldon, P; Snook, B; Tuo, S; Velkovska, J; Xu, Q; Arenton, M W; Cox, B; Francis, B; Goodell, J; Hirosky, R; Ledovskoy, A; Li, H; Lin, C; Neu, C; Sinthuprasith, T; Sun, X; Wang, Y; Wolfe, E; Wood, J; Xia, F; Clarke, C; Harr, R; Karchin, P E; Kottachchi Kankanamge Don, C; Lamichhane, P; Sturdy, J; Belknap, D A; Carlsmith, D; Cepeda, M; Dasu, S; Dodd, L; Duric, S; Gomber, B; Grothe, M; Hall-Wilton, R; Herndon, M; Hervé, A; Klabbers, P; Lanaro, A; Levine, A; Long, K; Loveless, R; Mohapatra, A; Ojalvo, I; Perry, T; Pierro, G A; Polese, G; Ruggles, T; Sarangi, T; Savin, A; Sharma, A; Smith, N; Smith, W H; Taylor, D; Woods, N

New sets of parameters ("tunes") for the underlying-event (UE) modelling of the pythia8, pythia6 and herwig++ Monte Carlo event generators are constructed using different parton distribution functions. Combined fits to CMS UE proton-proton ([Formula: see text]) data at [Formula: see text] and to UE proton-antiproton ([Formula: see text]) data from the CDF experiment at lower [Formula: see text], are used to study the UE models and constrain their parameters, providing thereby improved predictions for proton-proton collisions at 13[Formula: see text]. In addition, it is investigated whether the values of the parameters obtained from fits to UE observables are consistent with the values determined from fitting observables sensitive to double-parton scattering processes. Finally, comparisons are presented of the UE tunes to "minimum bias" (MB) events, multijet, and Drell-Yan ([Formula: see text] lepton-antilepton+jets) observables at 7 and 8[Formula: see text], as well as predictions for MB and UE observables at 13[Formula: see text].

25 CFR 547.10 - What are the minimum standards for Class II gaming system critical events?

Code of Federal Regulations, 2011 CFR

2011-04-01

... GAMES § 547.10 What are the minimum standards for Class II gaming system critical events? This section... component can no longer be considered reliable. Accordingly, any game play on the affected component shall... or the medium itself has some fault.Any game play on the affected component shall cease immediately...

25 CFR 547.10 - What are the minimum standards for Class II gaming system critical events?

Code of Federal Regulations, 2012 CFR

2012-04-01

... GAMES § 547.10 What are the minimum standards for Class II gaming system critical events? This section... component can no longer be considered reliable. Accordingly, any game play on the affected component shall... or the medium itself has some fault.Any game play on the affected component shall cease immediately...

GRADE guidelines: 5. Rating the quality of evidence--publication bias.

PubMed

Guyatt, Gordon H; Oxman, Andrew D; Montori, Victor; Vist, Gunn; Kunz, Regina; Brozek, Jan; Alonso-Coello, Pablo; Djulbegovic, Ben; Atkins, David; Falck-Ytter, Yngve; Williams, John W; Meerpohl, Joerg; Norris, Susan L; Akl, Elie A; Schünemann, Holger J

2011-12-01

In the GRADE approach, randomized trials start as high-quality evidence and observational studies as low-quality evidence, but both can be rated down if a body of evidence is associated with a high risk of publication bias. Even when individual studies included in best-evidence summaries have a low risk of bias, publication bias can result in substantial overestimates of effect. Authors should suspect publication bias when available evidence comes from a number of small studies, most of which have been commercially funded. A number of approaches based on examination of the pattern of data are available to help assess publication bias. The most popular of these is the funnel plot; all, however, have substantial limitations. Publication bias is likely frequent, and caution in the face of early results, particularly with small sample size and number of events, is warranted. Copyright © 2011 Elsevier Inc. All rights reserved.

Generalized run-and-turn motions: From bacteria to Lévy walks

NASA Astrophysics Data System (ADS)

Detcheverry, François

2017-07-01

Swimming bacteria exhibit a repertoire of motility patterns, in which persistent motion is interrupted by turning events. What are the statistical properties of such random walks? If some particular instances have long been studied, the general case where turning times do not follow a Poisson process has remained unsolved. We present a generic extension of the continuous time random walks formalism relying on operators and noncommutative calculus. The approach is first applied to a unimodal model of bacterial motion. We examine the existence of a minimum in velocity correlation function and discuss the maximum of diffusivity at an optimal value of rotational diffusion. The model is then extended to bimodal patterns and includes as particular cases all swimming strategies: run-and-tumble, run-stop, run-reverse and run-reverse-flick. We characterize their velocity correlation functions and investigate how bimodality affects diffusivity. Finally, the wider applicability of the method is illustrated by considering curved trajectories and Lévy walks. Our results are relevant for intermittent motion of living beings, be they swimming micro-organisms or crawling cells.

Biases in the production and reception of collective knowledge: the case of hindsight bias in Wikipedia.

PubMed

Oeberst, Aileen; von der Beck, Ina; D Back, Mitja; Cress, Ulrike; Nestler, Steffen

2017-04-17

The Web 2.0 enabled collaboration at an unprecedented level. In one of the flagships of mass collaboration-Wikipedia-a large number of authors socially negotiate the world's largest compendium of knowledge. Several guidelines in Wikipedia restrict contributions to verifiable information from reliable sources to ensure recognized knowledge. Much psychological research demonstrates, however, that individual information processing is biased. This poses the question whether individual biases translate to Wikipedia articles or whether they are prevented by its guidelines. The present research makes use of hindsight bias to examine this question. To this end, we analyzed foresight and hindsight versions of Wikipedia articles regarding a broad variety of events (Study 1). We found the majority of articles not to contain traces of hindsight bias-contrary to prior individual research. However, for a particular category of events-disasters-we found robust evidence for hindsight bias. In a lab experiment (Study 2), we then examined whether individuals' hindsight bias is translated into articles under controlled conditions and tested whether collaborative writing-as present in Wikipedia-affects the resultant bias (vs. individual writing). Finally, we investigated the impact of biased Wikipedia articles on readers (Study 3). As predicted, biased articles elicited a hindsight bias in readers, who had not known of the event previously. Moreover, biased articles also affected individuals who knew about the event already, and who had already developed a hindsight bias: biased articles further increased their hindsight.

Running economy and energy cost of running with backpacks.

PubMed

Scheer, Volker; Cramer, Leoni; Heitkamp, Hans-Christian

2018-05-02

Running is a popular recreational activity and additional weight is often carried in backpacks on longer runs. Our aim was to examine running economy and other physiological parameters while running with a 1kg and 3 kg backpack at different submaximal running velocities. 10 male recreational runners (age 25 ± 4.2 years, VO2peak 60.5 ± 3.1 ml·kg-1·min-1) performed runs on a motorized treadmill of 5 minutes durations at three different submaximal speeds of 70, 80 and 90% of anaerobic lactate threshold (LT) without additional weight, and carrying a 1kg and 3 kg backpack. Oxygen consumption, heart rate, lactate and RPE were measured and analysed. Oxygen consumption, energy cost of running and heart rate increased significantly while running with a backpack weighing 3kg compared to running without additional weight at 80% of speed at lactate threshold (sLT) (p=0.026, p=0.009 and p=0.003) and at 90% sLT (p<0.001, p=0.001 and p=0.001). Running with a 1kg backpack showed a significant increase in heart rate at 80% sLT (p=0.008) and a significant increase in oxygen consumption and heart rate at 90% sLT (p=0.045 and p=0.007) compared to running without additional weight. While running at 70% sLT running economy and cardiovascular effort increased with weighted backpack running compared to running without additional weight, however these increases did not reach statistical significance. Running economy deteriorates and cardiovascular effort increases while running with additional backpack weight especially at higher submaximal running speeds. Backpack weight should therefore be kept to a minimum.

Brief Report: Can Metrics of Reporting Bias Enhance Early Autism Screening Measures?

ERIC Educational Resources Information Center

Taylor, Cora M.; Vehorn, Alison; Noble, Hylan; Weitlauf, Amy S.; Warren, Zachary E.

2014-01-01

The goal of the current study was to develop and pilot the utility of two simple internal response bias metrics, over-reporting and under-reporting, in terms of additive clinical value within common screening practices for early detection of autism spectrum disorder risk. Participants were caregivers and children under 36 months of age (n = 145)…

Early Warning and Early Action during the 2015-16 El Nino Event

NASA Astrophysics Data System (ADS)

Robertson, A. W.; Goddard, L. M.

2016-12-01

Strong El Niño events have a marked impact on regional climate worldwide through their influence on large-scale atmospheric circulation. As a result, seasonal climate forecasts show greater skill during El Niño events, which provide communities, governments and humanitarian agencies greater ability to plan and prepare. The scientific community has advanced considerably in the quality and content of information provided about El Niño and its impacts. As a result, society has become better aware of and engaged with this information. This talk will present some details on how we navigate the fine line between expectations and probabilistic forecasts, and how this information was used during the 2015-16 El Niño event. Examples are drawn from the health sector and food security community. Specific attention will be given to the importance of problem-focus and data availability in the appropriate tailoring of climate information for Early Warning/Early Action.

Arterial stiffness results from eccentrically biased downhill running exercise.

PubMed

Burr, J F; Boulter, M; Beck, K

2015-03-01

There is increasing evidence that select forms of exercise are associated with vascular changes that are in opposition to the well-accepted beneficial effects of moderate intensity aerobic exercise. To determine if alterations in arterial stiffness occur following eccentrically accentuated aerobic exercise, and if changes are associated with measures of muscle soreness. Repeated measures experimental cohort. Twelve (m=8/f=4) moderately trained (VO₂max=52.2 ± 7.4 ml kg(-1)min(-1)) participants performed a downhill run at -12° grade using a speed that elicited 60% VO₂max for 40 min. Cardiovascular and muscle soreness measures were collected at baseline and up to 72 h post-running. Muscle soreness peaked at 48 h (p=<0.001). Arterial stiffness similarly peaked at 48 h (p=0.04) and remained significantly elevated above baseline through 72 h. Eccentrically accentuated downhill running is associated with arterial stiffening in the absence of an extremely prolonged duration or fast pace. The timing of alterations coincides with the well-documented inflammatory response that occurs from the muscular insult of downhill running, but whether the observed changes are a result of either systemic or local inflammation is yet unclear. These findings may help to explain evidence of arterial stiffening in long-term runners and following prolonged duration races wherein cumulative eccentric loading is high. Copyright © 2014 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

Early attentional bias for negative words when competition is induced.

PubMed

Ho, Ming-Chou; Li, Shuo-Heng; Yeh, Su-Ling

2016-05-01

Previous research (Zeelenberg, Wagenmakers, & Rotteveel, 2006) revealed that emotionally meaningful words were identified significantly better than neutral words, with no difference between positive and negative words. Since in that study only a single target word was displayed at a time, we hypothesized that the equivalent performances for positive and negative words were due to a lack of competition. To test this, in our Experiment 1, we replicated Zeelenberg and colleagues' finding, using emotion-laden Chinese words and the identical data-limited method, which measured the accuracy of a briefly shown target. We then introduced competition in Experiment 2 by simultaneously presenting two words during the target frame, and found evidence for an early attentional bias to negative words. In Experiment 3, we confirmed that the bias in Experiment 2 was not due to the inevitable repetition of stimuli. Taken together, these results support our hypothesis that, in the presence of competition, negative words receive attentional priority and consequently have enhanced perceptual representations.

Pacing during an ultramarathon running event in hilly terrain

PubMed Central

Cole-Hunter, Tom; Wiegand, Aaron N.; Solomon, Colin

2016-01-01

Purpose The dynamics of speed selection as a function of distance, or pacing, are used in recreational, competitive, and scientific research situations as an indirect measure of the psycho-physiological status of an individual. The purpose of this study was to determine pacing on level, uphill and downhill sections of participants in a long (>80 km) ultramarathon performed on trails in hilly terrain. Methods Fifteen ultramarathon runners competed in a  173 km event (five finished at  103 km) carrying a Global-Positioning System (GPS) device. Using the GPS data, we determined the speed, relative to average total speed, in level (LEV), uphill (UH) and downhill (DH) gradient categories as a function of total distance, as well as the correlation between overall performance and speed variability, speed loss, and total time stopped. Results There were no significant differences in normality, variances or means in the relative speed in 173-km and 103-km participants. Relative speed decreased in LEV, UH and DH. The main component of speed loss occurred between 5% and 50% of the event distance in LEV, and between 5% and 95% in UH and DH. There were no significant correlations between overall performance and speed loss, the variability of speed, or total time stopped. Conclusions Positive pacing was observed at all gradients, with the main component of speed loss occurring earlier (mixed pacing) in LEV compared to UH and DH. A speed reserve (increased speed in the last section) was observed in LEV and UH. The decrease in speed and variability of speed were more important in LEV and DH than in UH. The absence of a significant correlation between overall performance and descriptors of pacing is novel and indicates that pacing in ultramarathons in trails and hilly terrain differs to other types of running events. PMID:27812406

Early group bias in the Faroe Islands: Cultural variation in children's group-based reasoning.

PubMed

Schug, Mariah G; Shusterman, Anna; Barth, Hilary; Patalano, Andrea L

2016-01-01

Recent developmental research demonstrates that group bias emerges early in childhood. However, little is known about the extent to which bias in minimal (i.e., arbitrarily assigned) groups varies with children's environment and experience, and whether such bias is universal across cultures. In this study, the development of group bias was investigated using a minimal groups paradigm with 46 four- to six-year-olds from the Faroe Islands. Children observed in-group and out-group members exhibiting varying degrees of prosocial behaviour (egalitarian or stingy sharing). Children did not prefer their in-group in the pretest, but a pro-in-group and anti-out-group sentiment emerged in both conditions in the posttest. Faroese children's response patterns differ from those of American children [Schug, M. G., Shusterman, A., Barth, H., & Patalano, A. L. (2013). Minimal-group membership influences children's responses to novel experience with group members. Developmental Science, 16(1), 47-55], suggesting that intergroup bias shows cultural variation even in a minimal groups context.

To run or not to run: a post-meniscectomy qualitative risk analysis model for osteoarthritis when considering a return to recreational running.

PubMed

Baumgarten, Bob

2007-01-01

The increased likelihood of osteoarthritic change in the tibiofemoral joint following meniscectomy is well documented. This awareness often leads medical practitioners to advise patients previously engaged in recreational running who have undergone meniscectomy to cease all recreational running. This literature review examines the following questions: 1) Is there evidence to demonstrate that runners, post-meniscectomy, incur a great enough risk for early degenerative OA to cease all running? 2) Does the literature yield risk factors for early OA that would guide a physical therapist with regard to advising the post-meniscectomy patient contemplating a return to recreational running? Current literature related to meniscal structure and function, etiology and definition of osteoarthritis, methods for assessing osteoarthritis, relationship between running and osteoarthritis, and relationship between meniscectomy and osteoarthritis are reviewed. This review finds that while the probability for early osteoarthritis in the post-meniscectomy population is substantial, it is a probability and not a certainty. To help guide a physical therapist with regard to advising the patient for a safe return to running following a meniscectomy, a qualitative risk assessment based on identified risk factors for osteoarthritis in both the running and the post-meniscectomy populations is proposed.

Physiological demands of running during long distance runs and triathlons.

PubMed

Hausswirth, C; Lehénaff, D

2001-01-01

The aim of this review article is to identify the main metabolic factors which have an influence on the energy cost of running (Cr) during prolonged exercise runs and triathlons. This article proposes a physiological comparison of these 2 exercises and the relationship between running economy and performance. Many terms are used as the equivalent of 'running economy' such as 'oxygen cost', 'metabolic cost', 'energy cost of running', and 'oxygen consumption'. It has been suggested that these expressions may be defined by the rate of oxygen uptake (VO2) at a steady state (i.e. between 60 to 90% of maximal VO2) at a submaximal running speed. Endurance events such as triathlon or marathon running are known to modify biological constants of athletes and should have an influence on their running efficiency. The Cr appears to contribute to the variation found in distance running performance among runners of homogeneous level. This has been shown to be important in sports performance, especially in events like long distance running. In addition, many factors are known or hypothesised to influence Cr such as environmental conditions, participant specificity, and metabolic modifications (e.g. training status, fatigue). The decrease in running economy during a triathlon and/or a marathon could be largely linked to physiological factors such as the enhancement of core temperature and a lack of fluid balance. Moreover, the increase in circulating free fatty acids and glycerol at the end of these long exercise durations bear witness to the decrease in Cr values. The combination of these factors alters the Cr during exercise and hence could modify the athlete's performance in triathlons or a prolonged run.

Event representations constrain the structure of language: Sign language as a window into universally accessible linguistic biases.

PubMed

Strickland, Brent; Geraci, Carlo; Chemla, Emmanuel; Schlenker, Philippe; Kelepir, Meltem; Pfau, Roland

2015-05-12

According to a theoretical tradition dating back to Aristotle, verbs can be classified into two broad categories. Telic verbs (e.g., "decide," "sell," "die") encode a logical endpoint, whereas atelic verbs (e.g., "think," "negotiate," "run") do not, and the denoted event could therefore logically continue indefinitely. Here we show that sign languages encode telicity in a seemingly universal way and moreover that even nonsigners lacking any prior experience with sign language understand these encodings. In experiments 1-5, nonsigning English speakers accurately distinguished between telic (e.g., "decide") and atelic (e.g., "think") signs from (the historically unrelated) Italian Sign Language, Sign Language of the Netherlands, and Turkish Sign Language. These results were not due to participants' inferring that the sign merely imitated the action in question. In experiment 6, we used pseudosigns to show that the presence of a salient visual boundary at the end of a gesture was sufficient to elicit telic interpretations, whereas repeated movement without salient boundaries elicited atelic interpretations. Experiments 7-10 confirmed that these visual cues were used by all of the sign languages studied here. Together, these results suggest that signers and nonsigners share universally accessible notions of telicity as well as universally accessible "mapping biases" between telicity and visual form.

Negativity bias for sad faces in depression: An event-related potential study.

PubMed

Dai, Qin; Wei, Juanjuan; Shu, Xiaorui; Feng, Zhengzhi

2016-12-01

Negativity bias in depression has been previously confirmed. However, mainly during a valence category task, it remains unclear how happy or unhappy individuals perceive emotional materials. Moreover, cerebral alteration measurements during a valence judgment task is lacking. The present study aimed to explore a valence judgment of a valence rating task, combined with event-related potential (ERP) recording. Healthy controls, individuals with sub-clinical depression, and patients diagnosed with major depressive disorder (MDD) were recruited. Twenty-four subjects in each group completed a valence rating task, during which the ERP amplitudes were recorded. The MDD group had lower valence scores, faster responses, and greater N1 amplitudes for sad faces, whereas individuals with sub-clinical depression had faster responses and greater P1 amplitudes for all faces but lower valence scores and greater P2 amplitudes for happy faces. The findings suggest the tendency toward a negativity bias in valence ratings in patients with depression supported by behavioral and cerebral evidence, which is a latent trait of depression, possibly associated with the vulnerability of depression. The current study offers the first experimental evidence of cognitive and cerebral biomarkers of negativity bias in valence ratings in depression, which confirms Beck's cognitive theory and gives important direction for clinical therapy. Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Cognitive Biases and the Link between Shyness and Social Anxiety in Early Adolescence

ERIC Educational Resources Information Center

Weeks, Murray; Ooi, Laura L.; Coplan, Robert J.

2016-01-01

Shy children display wariness in unfamiliar social situations and often experience feelings of social anxiety. This study explored the potential mediating role of cognitive biases in the link between shyness and social anxiety in early adolescence. In particular, we focused on judgments of the probability and cost of negative social situations…

Annual minimum temperature variations in early 21st century in Punjab, Pakistan

NASA Astrophysics Data System (ADS)

Jahangir, Misbah; Maria Ali, Syeda; Khalid, Bushra

2016-01-01

Climate change is a key emerging threat to the global environment. It imposes long lasting impacts both at regional and national level. In the recent era, global warming and extreme temperatures have drawn great interest to the scientific community. As in a past century considerable increase in global surface temperatures have been observed and predictions revealed that it will continue in the future. In this regard, current study mainly focused on analysis of regional climatic change (annual minimum temperature trends and its correlation with land surface temperatures in the early 21st century in Punjab) for a period of 1979-2013. The projected model data European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-Interim) has been used for eight Tehsils of Punjab i.e., annual minimum temperatures and annual seasonal temperatures. Trend analysis of annual minimum and annual seasonal temperature in (Khushab, Noorpur, Sargodha, Bhalwal, Sahiwal, Shahpur, Sillanwali and Chinoit) tehsils of Punjab was carried out by Regression analysis and Mann-Kendall test. Landsat 5 Thematic Mapper (TM) data was used in comparison with Model data for the month of May from the years 2000, 2009 and 2010. Results showed that no significant trends were observed in annual minimum temperature. A significant change was observed in Noorpur, Bhalwal, Shahpur, Sillanwali, Sahiwal, Chinoit and Sargodha tehsils during spring season, which indicated that this particular season was a transient period of time.

Biased learning affects mate choice in a butterfly.

PubMed

Westerman, Erica L; Hodgins-Davis, Andrea; Dinwiddie, April; Monteiro, Antónia

2012-07-03

Early acquisition of mate preferences or mate-preference learning is associated with signal diversity and speciation in a wide variety of animal species. However, the diversity of mechanisms of mate-preference learning across taxa remains poorly understood. Using the butterfly Bicyclus anynana we uncover a mechanism that can lead to directional sexual selection via mate-preference learning: a bias in learning enhanced ornamentation, which is independent of preexisting mating biases. Naïve females mated preferentially with wild-type males over males with enhanced wing ornamentation, but females briefly exposed to enhanced males mated significantly more often with enhanced males. In contrast, females exposed to males with reduced wing ornamentation did not learn to prefer drab males. Thus, we observe both a learned change of a preexisting mating bias, and a bias in ability to learn enhanced male ornaments over reduced ornaments. Our findings demonstrate that females are able to change their preferences in response to a single social event, and suggest a role for biased learning in the evolution of visual sexual ornamentation.

A comparison of kinematic algorithms to estimate gait events during overground running.

PubMed

Smith, Laura; Preece, Stephen; Mason, Duncan; Bramah, Christopher

2015-01-01

The gait cycle is frequently divided into two distinct phases, stance and swing, which can be accurately determined from ground reaction force data. In the absence of such data, kinematic algorithms can be used to estimate footstrike and toe-off. The performance of previously published algorithms is not consistent between studies. Furthermore, previous algorithms have not been tested at higher running speeds nor used to estimate ground contact times. Therefore the purpose of this study was to both develop a new, custom-designed, event detection algorithm and compare its performance with four previously tested algorithms at higher running speeds. Kinematic and force data were collected on twenty runners during overground running at 5.6m/s. The five algorithms were then implemented and estimated times for footstrike, toe-off and contact time were compared to ground reaction force data. There were large differences in the performance of each algorithm. The custom-designed algorithm provided the most accurate estimation of footstrike (True Error 1.2 ± 17.1 ms) and contact time (True Error 3.5 ± 18.2 ms). Compared to the other tested algorithms, the custom-designed algorithm provided an accurate estimation of footstrike and toe-off across different footstrike patterns. The custom-designed algorithm provides a simple but effective method to accurately estimate footstrike, toe-off and contact time from kinematic data. Copyright © 2014 Elsevier B.V. All rights reserved.

Salinity changes and anoxia resulting from enhanced run-off during the late Permian global warming and mass extinction event

NASA Astrophysics Data System (ADS)

van Soelen, Elsbeth E.; Twitchett, Richard J.; Kürschner, Wolfram M.

2018-04-01

The late Permian biotic crisis had a major impact on marine and terrestrial environments. Rising CO2 levels following Siberian Trap volcanic activity were likely responsible for expanding marine anoxia and elevated water temperatures. This study focuses on one of the stratigraphically most expanded Permian-Triassic records known, from Jameson Land, East Greenland. High-resolution sampling allows for a detailed reconstruction of the changing environmental conditions during the extinction event and the development of anoxic water conditions. Since very little is known about how salinity was affected during the extinction event, we especially focus on the aquatic palynomorphs and infer changes in salinity from changes in the assemblage and morphology. The start of the extinction event, here defined by a peak in spore : pollen, indicating disturbance and vegetation destruction in the terrestrial environment, postdates a negative excursion in the total organic carbon, but predates the development of anoxia in the basin. Based on the newest estimations for sedimentation rates, the marine and terrestrial ecosystem collapse took between 1.6 and 8 kyr, a much shorter interval than previously estimated. The palynofacies and palynomorph records show that the environmental changes can be explained by enhanced run-off and increased primary productivity and water column stratification. A lowering in salinity is supported by changes in the acritarch morphology. The length of the processes of the acritarchs becomes shorter during the extinction event and we propose that these changes are evidence for a reduction in salinity in the shallow marine setting of the study site. This inference is supported by changes in acritarch distribution, which suggest a change in palaeoenvironment from open marine conditions before the start of the extinction event to more nearshore conditions during and after the crisis. In a period of sea-level rise, such a reduction in salinity can only be

Test Bias and the Culturally Different Early Adolescent.

ERIC Educational Resources Information Center

Roberts, Eileen; DeBlassie, Richard R.

1983-01-01

Defines test bias as a phenomenon in which test scores result in negative outcomes for certain groups, often lower socioeconomic groups and minorities. Discusses three manifestations of test bias including content, atmosphere, and use bias and presents recommendations for remedying bias problems in testing the culturally different. (JAC)

Hindsight Bias.

PubMed

Roese, Neal J; Vohs, Kathleen D

2012-09-01

Hindsight bias occurs when people feel that they "knew it all along," that is, when they believe that an event is more predictable after it becomes known than it was before it became known. Hindsight bias embodies any combination of three aspects: memory distortion, beliefs about events' objective likelihoods, or subjective beliefs about one's own prediction abilities. Hindsight bias stems from (a) cognitive inputs (people selectively recall information consistent with what they now know to be true and engage in sensemaking to impose meaning on their own knowledge), (b) metacognitive inputs (the ease with which a past outcome is understood may be misattributed to its assumed prior likelihood), and (c) motivational inputs (people have a need to see the world as orderly and predictable and to avoid being blamed for problems). Consequences of hindsight bias include myopic attention to a single causal understanding of the past (to the neglect of other reasonable explanations) as well as general overconfidence in the certainty of one's judgments. New technologies for visualizing and understanding data sets may have the unintended consequence of heightening hindsight bias, but an intervention that encourages people to consider alternative causal explanations for a given outcome can reduce hindsight bias. © The Author(s) 2012.

Social Anxiety-Linked Attention Bias to Threat Is Indirectly Related to Post-Event Processing Via Subjective Emotional Reactivity to Social Stress.

PubMed

Çek, Demet; Sánchez, Alvaro; Timpano, Kiara R

2016-05-01

Attention bias to threat (e.g., disgust faces) is a cognitive vulnerability factor for social anxiety occurring in early stages of information processing. Few studies have investigated the relationship between social anxiety and attention biases, in conjunction with emotional and cognitive responses to a social stressor. Elucidating these links would shed light on maintenance factors of social anxiety and could help identify malleable treatment targets. This study examined the associations between social anxiety level, attention bias to disgust (AB-disgust), subjective emotional and physiological reactivity to a social stressor, and subsequent post-event processing (PEP). We tested a mediational model where social anxiety level indirectly predicted subsequent PEP via its association with AB-disgust and immediate subjective emotional reactivity to social stress. Fifty-five undergraduates (45% female) completed a passive viewing task. Eye movements were tracked during the presentation of social stimuli (e.g., disgust faces) and used to calculate AB-disgust. Next, participants gave an impromptu speech in front of a video camera and watched a neutral video, followed by the completion of a PEP measure. Although there was no association between AB-disgust and physiological reactivity to the stressor, AB-disgust was significantly associated with greater subjective emotional reactivity from baseline to the speech. Analyses supported a partial mediation model where AB-disgust and subjective emotional reactivity to a social stressor partially accounted for the link between social anxiety levels and PEP. Copyright © 2016. Published by Elsevier Ltd.

Social anxiety and negative early life events in university students.

PubMed

Binelli, Cynthia; Ortiz, Ana; Muñiz, Armando; Gelabert, Estel; Ferraz, Liliana; S Filho, Alaor; Crippa, José Alexandre S; Nardi, Antonio E; Subirà, Susana; Martín-Santos, Rocío

2012-06-01

There is substantial evidence regarding the impact of negative life events during childhood on the aetiology of psychiatric disorders. We examined the association between negative early life events and social anxiety in a sample of 571 Spanish University students. In a cross-sectional survey conducted in 2007, we collected data through a semistructured questionnaire of sociodemographic variables, personal and family psychiatric history, and substance abuse. We assessed the five early negative life events: (i) the loss of someone close, (ii) emotional abuse, (iii) physical abuse, (iv) family violence, and (v) sexual abuse. All participants completed the Liebowitz Social Anxiety Scale. Mean (SD) age was 21 (4.5), 75% female, LSAS score was 40 (DP = 22), 14.2% had a psychiatric family history and 50.6% had negative life events during childhood. Linear regression analyses, after controlling for age, gender, and family psychiatric history, showed a positive association between family violence and social score (p = 0.03). None of the remaining stressors produced a significant increase in LSAS score (p > 0.05). University students with high levels of social anxiety presented higher prevalence of negative early life events. Thus, childhood family violence could be a risk factor for social anxiety in such a population.

The Relationship Between Early Life Events, Parental Attachment, and Psychopathic Tendencies in Adolescent Detainees.

PubMed

Christian, Erica J; Meltzer, Christine L; Thede, Linda L; Kosson, David S

2017-04-01

Despite increasing interest in understanding psychopathic traits in youth, the role of early environmental factors in the development of psychopathic traits is not well understood. No prior studies have directly examined the relationship between early life events and psychopathic traits. We examined links between life events in the first 4 years of life and indices of the core affective and interpersonal components of psychopathy. Additionally, we examined relationships between early life events, psychopathic traits, and attachment to parents among 206 adjudicated adolescents. Results indicated that the total number of early life events was positively correlated with indices of the affective component of psychopathy. Moreover, psychopathic traits moderated the relationship between the number of early life events and later reports of attachment to parents. Findings suggest that early environmental factors could have important implications for the development of psychopathic traits and may impact attachment to parents for youth with psychopathic traits.

No Own-Age Bias in 3-Year-Old Children: More Evidence for the Role of Early Experience in Building Face-Processing Biases

ERIC Educational Resources Information Center

Cassia, Viola Macchi; Pisacane, Antonella; Gava, Lucia

2012-01-01

This study aimed to investigate the presence of an own-age bias in young children who accumulated different amounts of early experience with child faces. Discrimination abilities for upright and inverted adult and child faces were tested using a delayed two-alternative, forced-choice matching-to-sample task in two groups of 3-year-old children,…

SLF Run & Walk

NASA Image and Video Library

2018-03-13

Kennedy Space Center employees and guests are off to a running start at the KSC Walk Run on the Shuttle Landing Facility runway. The annual event, part of Kennedy’s Safety and Health Days, offers 10K, 5K and 2-mile options in the spirit of friendly competition.

Biases in the subjective timing of perceptual events: Libet et al. (1983) revisited.

PubMed

Danquah, Adam N; Farrell, Martin J; O'Boyle, Donald J

2008-09-01

We report two experiments in which participants had to judge the time of occurrence of a stimulus relative to a clock. The experiments were based on the control condition used by Libet, Gleason, Wright, and Pearl [Libet, B., Gleason, C. A., Wright, E. W., & Pearl, D. K. (1983). Time of conscious intention to act in relation to onset of cerebral activities (readiness-potential): The unconscious initiation of a freely voluntary act. Brain 106, 623-642] to correct for any bias in the estimation of the time at which an endogenous event, the conscious intention to perform a movement, occurred. Participants' responses were affected systematically by the sensory modality of the stimulus and by the speed of the clock. Such findings demonstrate the variability in judging the time at which an exogenous event occurs and, by extension, suggest that such variability may also apply to the judging the time of occurrence of endogenous events. The reliability of participants' estimations of when they formed the conscious intention to perform a movement in Libet et al.'s (1983) study is therefore questionable.

Does the Owl Fly out of the Tree or Does the Owl Exit the Tree Flying? How L2 Learners Overcome Their L1 Lexicalization Biases

PubMed Central

Song, Lulu; Pulverman, Rachel; Pepe, Christina; Golinkoff, Roberta Michnick; Hirsh-Pasek, Kathy

2016-01-01

Learning a language is more than learning its vocabulary and grammar. For example, compared to English, Spanish uses many more path verbs such as ascender (‘to move upward’) and salir (‘to go out’), and expresses manner of motion optionally. English, in contrast, has many manner verbs (e.g., run, jog) and expresses path in prepositional phrases (e.g., out of the barn). The way in which a language encodes an event is known as its lexicalization pattern or bias. Using a written sentence elicitation task, we asked whether adult Spanish learners whose L1 was English adopted Spanish lexicalization biases, and what types of L2 exposure facilitated the learning of lexicalization biases. Results showed that advanced, but not intermediate, adult Spanish learners showed a path bias comparable to that found in native speakers of Spanish. Furthermore, study abroad experience is associated with better acquisition of L2 lexicalization biases when describing certain types of events. PMID:27103880

Electrocortical measures of information processing biases in social anxiety disorder: A review.

PubMed

Harrewijn, Anita; Schmidt, Louis A; Westenberg, P Michiel; Tang, Alva; van der Molen, Melle J W

2017-10-01

Social anxiety disorder (SAD) is characterized by information processing biases, however, their underlying neural mechanisms remain poorly understood. The goal of this review was to give a comprehensive overview of the most frequently studied EEG spectral and event-related potential (ERP) measures in social anxiety during rest, anticipation, stimulus processing, and recovery. A Web of Science search yielded 35 studies reporting on electrocortical measures in individuals with social anxiety or related constructs. Social anxiety was related to increased delta-beta cross-frequency correlation during anticipation and recovery, and information processing biases during early processing of faces (P1) and errors (error-related negativity). These electrocortical measures are discussed in relation to the persistent cycle of information processing biases maintaining SAD. Future research should further investigate the mechanisms of this persistent cycle and study the utility of electrocortical measures in early detection, prevention, treatment and endophenotype research. Copyright © 2017 Elsevier B.V. All rights reserved.

Method for early detection of cooling-loss events

DOEpatents

Bermudez, Sergio A.; Hamann, Hendrik; Marianno, Fernando J.

2015-06-30

A method of detecting cooling-loss event early is provided. The method includes defining a relative humidity limit and change threshold for a given space, measuring relative humidity in the given space, determining, with a processing unit, whether the measured relative humidity is within the defined relative humidity limit, generating a warning in an event the measured relative humidity is outside the defined relative humidity limit and determining whether a change in the measured relative humidity is less than the defined change threshold for the given space and generating an alarm in an event the change is greater than the defined change threshold.

Method for early detection of cooling-loss events

DOEpatents

Bermudez, Sergio A.; Hamann, Hendrik F.; Marianno, Fernando J.

2015-12-22

A method of detecting cooling-loss event early is provided. The method includes defining a relative humidity limit and change threshold for a given space, measuring relative humidity in the given space, determining, with a processing unit, whether the measured relative humidity is within the defined relative humidity limit, generating a warning in an event the measured relative humidity is outside the defined relative humidity limit and determining whether a change in the measured relative humidity is less than the defined change threshold for the given space and generating an alarm in an event the change is greater than the defined change threshold.

Highlighting in Early Childhood: Learning Biases Through Attentional Shifting.

PubMed

Burling, Joseph M; Yoshida, Hanako

2017-02-01

The literature on human and animal learning suggests that individuals attend to and act on cues differently based on the order in which they were learned. Recent studies have proposed that one specific type of learning outcome, the highlighting effect, can serve as a framework for understanding a number of early cognitive milestones. However, little is known how this learning effect itself emerges among children, whose memory and attention are much more limited compared to adults. Two experiments were conducted using different versions of the general highlighting paradigm: Experiment 1 tested 3 to 6 year olds with a newly developed image-based version of the paradigm, which was designed specifically to test young children. Experiment 2 tested the validity of an image-based implementation of the highlighting paradigm with adult participants. The results from Experiment 1 provide evidence for the highlighting effect among children 3-6 years old, and they suggest age-related differences in dividing attention among multiple cues during learning. Experiment 2 replicated results from previous studies by showing robust biases for both image-based and text-based versions of the highlighting task. This study suggests that sensitivity to learning order emerges early through the process of cued attention, and the role of the highlighting effect in early language learning is discussed. Copyright © 2016 Cognitive Science Society, Inc.

Perception and Bias in the Processing of Compound versus Phrasal Stress: Evidence from Event-Related Brain Potentials

ERIC Educational Resources Information Center

McCauley, Stewart M; Hestvik, Arild; Vogel, Irene

2013-01-01

Previous research using picture/word matching tasks has demonstrated a tendency to incorrectly interpret phrasally stressed strings as compounds. Using event-related potentials, we sought to determine whether this pattern stems from poor perceptual sensitivity to the compound/phrasal stress distinction, or from a post-perceptual bias in behavioral…

Sex differences in event-related potentials and attentional biases to emotional facial stimuli.

PubMed

Pfabigan, Daniela M; Lamplmayr-Kragl, Elisabeth; Pintzinger, Nina M; Sailer, Uta; Tran, Ulrich S

2014-01-01

Attentional processes play an important role in the processing of emotional information. Previous research reported attentional biases during stimulus processing in anxiety and depression. However, sex differences in the processing of emotional stimuli and higher prevalence rates of anxiety disorders among women, compared to men, suggest that attentional biases may also differ between the two sexes. The present study used a modified version of the dot probe task with happy, angry, and neutral facial stimuli to investigate the time course of attentional biases in healthy volunteers. Moreover, associations of attentional biases with alexithymia were examined on the behavioral and physiological level. Event-related potentials were measured while 21 participants (11 women) performed the task, utilizing also for the first time a difference wave approach in the analysis to highlight emotion-specific aspects. Women showed overall enhanced probe P1 amplitudes compared to men, in particular after rewarding facial stimuli. Using the difference wave approach, probe P1 amplitudes appeared specifically enhanced with regard to congruently presented happy facial stimuli among women, compared to men. Both methods yielded enhanced probe P1 amplitudes after presentation of the emotional stimulus in the left compared to the right visual hemifield. Probe P1 amplitudes correlated negatively with self-reported alexithymia, most of these correlations were only observable in women. Our results suggest that women orient their attention to a greater extent to facial stimuli than men and corroborate that alexithymia is a correlate of reduced emotional reactivity on a neuronal level. We recommend using a difference wave approach when addressing attentional processes of orientation and disengagement also in future studies.

Attention Training and the Threat Bias: An ERP Study

PubMed Central

O’Toole, Laura; Dennis, Tracy A.

2011-01-01

Anxiety is characterized by exaggerated attention to threat. Several studies suggest that this threat bias plays a causal role in the development and maintenance of anxiety disorders. Furthermore, although the threat bias can be reduced in anxious individuals and induced in non-anxious individual, the attentional mechanisms underlying these changes remain unclear. To address this issue, 49 non-anxious adults were randomly assigned to either attentional training toward or training away from threat using a modified version of the dot probe task. Behavioral measures of attentional biases were also generated pre- and post-training using the dot probe task. Event-related potentials (ERPs) were generated to threat and non-threat face pairs and probes during pre- and post-training assessments. Effects of training on behavioral measures of the threat bias were significant, but only for those participants showing pre-training biases. Attention training also influenced early spatial attention, as measured by post-training P1 amplitudes to cues. Results illustrate the importance of taking pre-training attention biases in non-anxious individuals into account when evaluating the effects of attention training and tracking physiological changes in attention following training. PMID:22083026

Who uses running apps and sports watches? Determinants and consumer profiles of event runners' usage of running-related smartphone applications and sports watches.

PubMed

Janssen, Mark; Scheerder, Jeroen; Thibaut, Erik; Brombacher, Aarnout; Vos, Steven

2017-01-01

Individual and unorganized sports with a health-related focus, such as recreational running, have grown extensively in the last decade. Consistent with this development, there has been an exponential increase in the availability and use of electronic monitoring devices such as smartphone applications (apps) and sports watches. These electronic devices could provide support and monitoring for unorganized runners, who have no access to professional trainers and coaches. The purpose of this paper is to gain insight into the characteristics of event runners who use running-related apps and sports watches. This knowledge is useful from research, design, and marketing perspectives to adequately address unorganized runners' needs, and to support them in healthy and sustainable running through personalized technology. Data used in this study are drawn from the standardized online Eindhoven Running Survey 2014 (ERS14). In total, 2,172 participants in the Half Marathon Eindhoven 2014 completed the questionnaire (a response rate of 40.0%). Binary logistic regressions were used to analyze the impact of socio-demographic variables, running-related variables, and psychographic characteristics on the use of running-related apps and sports watches. Next, consumer profiles were identified. The results indicate that the use of monitoring devices is affected by socio-demographics as well as sports-related and psychographic variables, and this relationship depends on the type of monitoring device. Therefore, distinctive consumer profiles have been developed to provide a tool for designers and manufacturers of electronic running-related devices to better target (unorganized) runners' needs through personalized and differentiated approaches. Apps are more likely to be used by younger, less experienced and involved runners. Hence, apps have the potential to target this group of novice, less trained, and unorganized runners. In contrast, sports watches are more likely to be used by a

Who uses running apps and sports watches? Determinants and consumer profiles of event runners’ usage of running-related smartphone applications and sports watches

PubMed Central

Scheerder, Jeroen; Thibaut, Erik; Brombacher, Aarnout

2017-01-01

Individual and unorganized sports with a health-related focus, such as recreational running, have grown extensively in the last decade. Consistent with this development, there has been an exponential increase in the availability and use of electronic monitoring devices such as smartphone applications (apps) and sports watches. These electronic devices could provide support and monitoring for unorganized runners, who have no access to professional trainers and coaches. The purpose of this paper is to gain insight into the characteristics of event runners who use running-related apps and sports watches. This knowledge is useful from research, design, and marketing perspectives to adequately address unorganized runners’ needs, and to support them in healthy and sustainable running through personalized technology. Data used in this study are drawn from the standardized online Eindhoven Running Survey 2014 (ERS14). In total, 2,172 participants in the Half Marathon Eindhoven 2014 completed the questionnaire (a response rate of 40.0%). Binary logistic regressions were used to analyze the impact of socio-demographic variables, running-related variables, and psychographic characteristics on the use of running-related apps and sports watches. Next, consumer profiles were identified. The results indicate that the use of monitoring devices is affected by socio-demographics as well as sports-related and psychographic variables, and this relationship depends on the type of monitoring device. Therefore, distinctive consumer profiles have been developed to provide a tool for designers and manufacturers of electronic running-related devices to better target (unorganized) runners’ needs through personalized and differentiated approaches. Apps are more likely to be used by younger, less experienced and involved runners. Hence, apps have the potential to target this group of novice, less trained, and unorganized runners. In contrast, sports watches are more likely to be used by a

Identifying the progenitors of present-day early-type galaxies in observational surveys: correcting `progenitor bias' using the Horizon-AGN simulation

NASA Astrophysics Data System (ADS)

Martin, G.; Kaviraj, S.; Devriendt, J. E. G.; Dubois, Y.; Pichon, C.; Laigle, C.

2018-03-01

As endpoints of the hierarchical mass-assembly process, the stellar populations of local early-type galaxies encode the assembly history of galaxies over cosmic time. We use Horizon-AGN, a cosmological hydrodynamical simulation, to study the merger histories of local early-type galaxies and track how the morphological mix of their progenitors evolves over time. We provide a framework for alleviating `progenitor bias' - the bias that occurs if one uses only early-type galaxies to study the progenitor population. Early types attain their final morphology at relatively early epochs - by z ˜ 1, around 60 per cent of today's early types have had their last significant merger. At all redshifts, the majority of mergers have one late-type progenitor, with late-late mergers dominating at z > 1.5 and early-early mergers becoming significant only at z < 0.5. Progenitor bias is severe at all but the lowest redshifts - e.g. at z ˜ 0.6, less than 50 per cent of the stellar mass in today's early types is actually in progenitors with early-type morphology, while, at z ˜ 2, studying only early types misses almost all (80 per cent) of the stellar mass that eventually ends up in local early-type systems. At high redshift, almost all massive late-type galaxies, regardless of their local environment or star formation rate, are progenitors of local early-type galaxies, as are lower mass (M⋆ < 1010.5 M_{⊙}) late-types as long as they reside in high-density environments. In this new era of large observational surveys (e.g. LSST, JWST), this study provides a framework for studying how today's early-type galaxies have been built up over cosmic time.

The 5- or 10-km Marikenloop Run: A Prospective Study of the Etiology of Running-Related Injuries in Women.

PubMed

van der Worp, Maarten P; de Wijer, Anton; van Cingel, Robert; Verbeek, André L M; Nijhuis-van der Sanden, Maria W G; Staal, J Bart

2016-06-01

Study Design Prospective cohort. Background The popularity of running events is still growing, particularly among women; however, little is known about the risk factors for running-related injuries in female runners. Objectives The aims of this study were to determine the incidence and characteristics (site and recurrence) of running-related injuries and to identify specific risk factors for running-related injuries among female runners training for a 5- or 10-km race. Methods Four hundred thirty-five women registered for the Marikenloop run of 5 or 10 km were recruited. Follow-up data were collected over 12 weeks using questionnaires, starting 8 weeks before the event and ending 4 weeks after the event. Two orthopaedic tests (navicular drop test and extension of the first metatarsophalangeal joint) were performed in the 8 weeks before the event. Running-related injuries, defined as running-related pain of the lower back and/or the lower extremity that restricted running for at least 1 day, were assessed at 1-, 2-, and 3-month follow-ups. Results Of 417 female runners with follow-up data (96%), 93 runners (22.3%) reported 109 running-related injuries, mainly of the hip/groin, knee, and lower leg. Multivariable Cox regression analysis showed that a weekly training distance of more than 30 km (hazard ratio = 3.28; 95% confidence interval [CI]: 1.23, 8.75) and a previous running injury longer than 12 months prior (hazard ratio = 1.88; 95% CI: 1.03, 3.45) were associated with the occurrence of running-related injuries. Conclusion Hip/groin, knee, and lower-leg injuries were common among female runners. Only weekly training distance (greater than 30 km) and previous running injury (greater than 12 months prior) were associated with running-related injuries in female runners training for a 5- or 10-km event. Level of Evidence Etiology, 2b. J Orthop Sports Phys Ther 2016;46(6):462-470. Epub 26 Apr 2016. doi:10.2519/jospt.2016.6402.

Spatiotemporal brain dynamics underlying attentional bias modifications.

PubMed

Sallard, Etienne; Hartmann, Lea; Ptak, Radek; Spierer, Lucas

2018-06-05

Exaggerated attentional biases toward specific elements of the environment contribute to the maintenance of several psychiatric conditions, such as biases to threatening faces in social anxiety. Although recent literature indicates that attentional bias modification may constitute an effective approach for psychiatric remediation, the underlying neurophysiological mechanisms remain unclear. We addressed this question by recording EEG in 24 healthy participants performing a modified dot-probe task in which pairs of neutral cues (colored shapes) were replaced by probe stimuli requiring a discrimination judgment. To induce an attentional bias toward or away from the cues, the probes were systematically presented either at the same or at the opposite position of a specific cue color. This paradigm enabled participants to spontaneously develop biases to initially unbiased, neutral cues, as measured by the response speed to the probe presented after the cues. Behavioral result indicated that the ABM procedure induced approach and avoidance biases. The influence of ABM on inhibitory control was assessed in a separated Go/NoGo task: Changes in AB did not influence participants' capacity to inhibit their responses to the cues. Attentional bias modification was associated with a topographic modulation of event-related potentials already 50-84 ms following the onset of the cues. Statistical analyses of distributed electrical source estimations revealed that the development of attentional biases was associated with decreased activity in the left temporo-parieto-occipital junction. These findings suggest that attentional bias modification affects early sensory processing phases related to the extraction of information based on stimulus saliency. Copyright © 2017. Published by Elsevier B.V.

Hindsight bias and outcome bias in the social construction of medical negligence: a review.

PubMed

Hugh, Thomas B; Dekker, Sidney W A

2009-05-01

Medical negligence has been the subject of much public debate in recent decades. Although the steep increase in the frequency and size of claims against doctors at the end of the last century appears to have plateaued, in Australia at least, medical indemnity costs and consequences are still a matter of concern for doctors, medical defence organisations and governments in most developed countries. Imprecision in the legal definition of negligence opens the possibility that judgments of this issue at several levels may be subject to hindsight and outcome bias. Hindsight bias relates to the probability of an adverse event perceived by a retrospective observer ("I would have known it was going to happen"), while outcome bias is a largely subconscious cognitive distortion produced by the observer's knowledge of the adverse outcome. This review examines the relevant legal, medical, psychological and sociological literature on the operation of these pervasive and universal biases in the retrospective evaluation of adverse events. A finding of medical negligence is essentially an after-the-event social construction and is invariably affected by hindsight bias and knowledge of the adverse outcome. Such biases obviously pose a threat to the fairness of judgments. A number of debiasing strategies have been suggested but are relatively ineffective because of the universality and strength of these biases and the inherent difficulty of concealing from expert witnesses knowledge of the outcome. Education about the effect of the biases is therefore important for lawyers, medical expert witnesses and the judiciary.

Bias Correction for Assimilation of Retrieved AIRS Profiles of Temperature and Humidity

NASA Technical Reports Server (NTRS)

Blankenship, Clay; Zavodsky, Brad; Blackwell, William

2014-01-01

Atmospheric Infrared Sounder (AIRS) is a hyperspectral radiometer aboard NASA's Aqua satellite designed to measure atmospheric profiles of temperature and humidity. AIRS retrievals are assimilated into the Weather Research and Forecasting (WRF) model over the North Pacific for some cases involving "atmospheric rivers". These events bring a large flux of water vapor to the west coast of North America and often lead to extreme precipitation in the coastal mountain ranges. An advantage of assimilating retrievals rather than radiances is that information in partly cloudy fields of view can be used. Two different Level 2 AIRS retrieval products are compared: the Version 6 AIRS Science Team standard retrievals and a neural net retrieval from MIT. Before assimilation, a bias correction is applied to adjust each layer of retrieved temperature and humidity so the layer mean values agree with a short-term model climatology. WRF runs assimilating each of the products are compared against each other and against a control run with no assimilation. This paper will describe the bias correction technique and results from forecasts evaluated by validation against a Total Precipitable Water (TPW) product from CIRA and against Global Forecast System (GFS) analyses.

Cognitive Biases for Social Alcohol-Related Pictures and Alcohol Use in Specific Social Settings: An Event-Level Study.

PubMed

Groefsema, Martine; Engels, Rutger; Kuntsche, Emmanuel; Smit, Koen; Luijten, Maartje

2016-09-01

Alcohol use occurs mainly among friends, in social contexts, and for social reasons. Moreover, cognitive biases, such as attentional and approach biases, have repeatedly been associated with alcohol use. This study aimed to test whether nondependent drinkers display cognitive biases for social alcohol-related (SA) pictures and whether these biases are associated with alcohol use in social drinking contexts. The visual dot probe task and stimulus-response compatibility tasks were used to measure attentional and approach biases for alcohol-related pictures at baseline. Event-level alcohol use was measured using Ecological Momentary Assessments via personal smartphones. One hundred and ninety-two young adults (51.6% men; Mage  = 20.73) completed the study, resulting in 11,257 assessments conducted on Thursday, Friday, and Saturday evenings for 5 consecutive weeks. While no overall attentional bias for alcohol-related pictures was found, young adults showed an approach bias for both social and nonsocial alcohol-related pictures. Multilevel models revealed no direct association between cognitive biases for alcohol-related pictures and alcohol use. However, higher levels of attentional bias for SA pictures were associated with more drinking when individuals were surrounded by a greater number of friends of opposite gender. Higher levels of an approach bias for SA pictures were associated with more drinking in women surrounded by a greater number of friends of the same gender. In a nondependent sample, cognitive biases for SA pictures could not be associated with drinking directly. However, a cognitive bias for SA pictures moderated the association between alcohol use and number of friends present. As most observed effects were gender and situation specific, replication of these effects is warranted. Copyright © 2016 by the Research Society on Alcoholism.

First Results from BM@N Technical Run with Deuteron Beam

NASA Astrophysics Data System (ADS)

Baranov, D.; Kapishin, M.; Kulish, E.; Maksymchuk, A.; Mamontova, T.; Pokatashkin, G.; Rufanov, I.; Vasendina, V.; Zinchenko, A.

2018-03-01

BM@N (Baryonic Matter at Nuclotron) is the first experiment to be realized at the accelerator complex of NICA-Nuclotron at JINR (Dubna). The aim of the experiment is to study interactions of relativistic heavy ion beams with a kinetic energy from 1 to 4.5 AGeV with fixed targets. The BM@N set-up at the starting phase of the experiment is introduced. First results of the analysis of minimum bias experimental data collected in the technical run in interactions of the deuteron beam of 4 AGeV with different targets are presented. The spacial, momentum and primary vertex resolution of the GEM tracker are studied. The signal of Lambda-hyperon is reconstructed in the proton-pion invariant mass spectrum. The data results are described by Monte Carlo simulations. The investigation has been performed at the Laboratory of High Energy Physics, JINR.

Association of a trait-like bias towards the perception of negative subjective life events with risk of developing premenstrual symptoms.

PubMed

Gonda, Xenia; Fountoulakis, Konstantinos N; Csukly, Gabor; Telek, Tamas; Pap, Dorottya; Rihmer, Zoltan; Bagdy, Gyorgy

2010-04-16

Premenstrual symptoms affect the majority of healthy women. Premenstrual symptomatology has earlier been linked to stress and a state-like alteration in the perception of life events in the late-luteal phase of the menstrual cycle. We hypothesised that there is also a trait-like negative bias in the perception of life events evident throughout the whole cycle which is associated with the likelihood to manifest more marked symptoms in the late-luteal phase of the cycle. 88 healthy women completed the PRISM calendar for three consecutive cycles and the Objective and Subjective Event Checklist during the follicular phase of the first cycle. Association between PRISM score change from the follicular through the late-luteal phase and life event variables was investigated by Generalized Linear Model Analysis (GENMOD). The PRISM score change showed a significant negative association with the ratio of positive subjective life events and a significant positive association with the ratio of negative subjective life events. There were no significant results in case of the objective life events. Our results indicate that women manifesting a more marked increase of symptoms from the late follicular through the late-luteal phase of the menstrual cycle are more likely to notice negative subjective life events and less likely to notice positive subjective life events. This suggest a trait-like negative bias in the perception of life events present throughout the whole reproductive cycle which may play an important role in the emergence of premenstrual symptoms. Copyright 2010 Elsevier Inc. All rights reserved.

Influential factors of red-light running at signalized intersection and prediction using a rare events logistic regression model.

PubMed

Ren, Yilong; Wang, Yunpeng; Wu, Xinkai; Yu, Guizhen; Ding, Chuan

2016-10-01

Red light running (RLR) has become a major safety concern at signalized intersection. To prevent RLR related crashes, it is critical to identify the factors that significantly impact the drivers' behaviors of RLR, and to predict potential RLR in real time. In this research, 9-month's RLR events extracted from high-resolution traffic data collected by loop detectors from three signalized intersections were applied to identify the factors that significantly affect RLR behaviors. The data analysis indicated that occupancy time, time gap, used yellow time, time left to yellow start, whether the preceding vehicle runs through the intersection during yellow, and whether there is a vehicle passing through the intersection on the adjacent lane were significantly factors for RLR behaviors. Furthermore, due to the rare events nature of RLR, a modified rare events logistic regression model was developed for RLR prediction. The rare events logistic regression method has been applied in many fields for rare events studies and shows impressive performance, but so far none of previous research has applied this method to study RLR. The results showed that the rare events logistic regression model performed significantly better than the standard logistic regression model. More importantly, the proposed RLR prediction method is purely based on loop detector data collected from a single advance loop detector located 400 feet away from stop-bar. This brings great potential for future field applications of the proposed method since loops have been widely implemented in many intersections and can collect data in real time. This research is expected to contribute to the improvement of intersection safety significantly. Copyright © 2016 Elsevier Ltd. All rights reserved.

Registry on acute cardiovascular events during endurance running races: the prospective RACE Paris registry.

PubMed

Gerardin, Benoît; Collet, Jean-Philippe; Mustafic, Hazrije; Bellemain-Appaix, Anne; Benamer, Hakim; Monsegu, Jacques; Teiger, Emmanuel; Livarek, Bernard; Jaffry, Murielle; Lamhaut, Lionel; Fleischel, Catherine; Aubry, Pierre

2016-08-21

Long distance running races are associated with a low risk of life-threatening events much often attributed to hypertrophic cardiomyopathy. However, retrospective analyses of aetiology lack consistency. Incidence and aetiology of life-threatening/fatal events were assessed in long distance races in the prospective Registre des Accidents Cardiaques lors des courses d'Endurance (RACE Paris Registry) from October 2006 to September 2012. Characteristics of life-threatening/fatal events were analysed by interviewing survivors and reviewing medical records including post-mortem data of each case. Seventeen life-threatening events were identified of 511 880 runners of which two were fatal. The vast majority were cardiovascular events (13/17) occurring in experienced male runners [mean (±SD) age 43 ± 10 years], with infrequent cardiovascular risk factors, atypical warning symptoms prior to the race or negative treadmill test when performed. Acute myocardial ischaemia was the predominant aetiology (8 of 13) and led to immediate myocardial revascularization. All cases with initial shockable rhythm survived. There was no difference in event rate according to marathons vs. half-marathons and events were clustered at the end of the race. A meta-analysis of all available studies including the RACE Paris registry (n = 6) demonstrated a low prevalence of life-threatening events (0.75/100 000) and that presentation with non-shockable rhythm [OR = 29.9; 95% CI (4.0-222.5), P = 0.001] or non-ischaemic aetiology [OR = 6.4; 95% CI (1.4-28.8), P = 0.015] were associated with case-fatality. Life-threatening/fatal events during long distance races are rare, most often unpredictable and mainly due to acute myocardial ischaemia. Presentation with non-shockable rhythm and non-ischaemic aetiology are the major determinant of case fatality. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.

Social interaction anxiety and the discounting of positive interpersonal events.

PubMed

Vassilopoulos, Stephanos P; Banerjee, Robin

2010-10-01

Recent research has indicated that individuals with social interaction anxiety make biased interpretations of positive social interactions, with greater general apprehension in response to such events and more negative predictions about the future. There has also been some preliminary evidence for a second facet of interpretation bias, namely a failure to accept others' positive reactions at face value, but this has so far not been adequately studied. The present study developed a new measure of this "discounting" dimension and utilized a nonclinical sample of undergraduate students to provide an initial analysis of the scale. Results provide early support for the psychometric properties of our scale, and indicate that discounting mediates the relationship between social interaction anxiety and low positive affect, over and above the previously studied aspect of positive event interpretation bias. The implications for treatment interventions and further research are discussed.

Cognitive and neural mechanisms of decision biases in recognition memory.

PubMed

Windmann, Sabine; Urbach, Thomas P; Kutas, Marta

2002-08-01

In recognition memory tasks, stimuli can be classified as "old" either on the basis of accurate memory or a bias to respond "old", yet bias has received little attention in the cognitive neuroscience literature. Here we examined the pattern and timing of bias-related effects in event-related brain potentials (ERPs) to determine whether the bias is linked more to memory retrieval or to response verification processes. Participants were divided into a High Bias and a Low Bias group according to their bias to respond "old". These groups did not differ in recognition accuracy or in the ERP pattern to items that actually were old versus new (Objective Old/New Effect). However, when the old/new distinction was based on each subject's perspective, i.e. when items judged "old" were compared with those judged "new" (Subjective Old/New Effect), significant group differences were observed over prefrontal sites with a timing (300-500 ms poststimulus) more consistent with bias acting early on memory retrieval processes than on post-retrieval response verification processes. In the standard old/new effect (Hits vs Correct Rejections), these group differences were intermediate to those for the Objective and the Subjective comparisons, indicating that such comparisons are confounded by response bias. We propose that these biases are top-down controlled processes mediated by prefrontal cortex areas.

"It runs in my family …": The association of perceived family history with body dissatisfaction and weight bias internalization among overweight women.

PubMed

Eisenberg, Miriam H; Street, Richard L; Persky, Susan

2017-04-01

Aspects of poor body acceptance (BA), such as internalized weight bias and dissatisfaction with one's shape and size, are the strongest predictors of disordered eating and are associated with reduced engagement in healthy behaviors. Perceiving oneself as having a family history of overweight (PFH) could boost BA by increasing attributions for inherited, biological causes of weight. A community sample of 289 women who were overweight from the Washington, DC metropolitan area who were dissatisfied with their current weight (68% Black; 32% White) enrolled in this study in 2012. PFH of overweight was associated with decreased internalized weight bias among white women and marginally increased body shape satisfaction generally. The relationship between PFH and BA was not explained by biological attributions for weight. Perceptions that overweight runs in one's family can be protective with respect to BA. This is suggestive of the potential benefit of integrating family-based approaches into weight management interventions.

Producing physically consistent and bias free extreme precipitation events over the Switzerland: Bridging gaps between meteorology and impact models

NASA Astrophysics Data System (ADS)

José Gómez-Navarro, Juan; Raible, Christoph C.; Blumer, Sandro; Martius, Olivia; Felder, Guido

2016-04-01

Extreme precipitation episodes, although rare, are natural phenomena that can threat human activities, especially in areas densely populated such as Switzerland. Their relevance demands the design of public policies that protect public assets and private property. Therefore, increasing the current understanding of such exceptional situations is required, i.e. the climatic characterisation of their triggering circumstances, severity, frequency, and spatial distribution. Such increased knowledge shall eventually lead us to produce more reliable projections about the behaviour of these events under ongoing climate change. Unfortunately, the study of extreme situations is hampered by the short instrumental record, which precludes a proper characterization of events with return period exceeding few decades. This study proposes a new approach that allows studying storms based on a synthetic, but physically consistent database of weather situations obtained from a long climate simulation. Our starting point is a 500-yr control simulation carried out with the Community Earth System Model (CESM). In a second step, this dataset is dynamically downscaled with the Weather Research and Forecasting model (WRF) to a final resolution of 2 km over the Alpine area. However, downscaling the full CESM simulation at such high resolution is infeasible nowadays. Hence, a number of case studies are previously selected. This selection is carried out examining the precipitation averaged in an area encompassing Switzerland in the ESM. Using a hydrological criterion, precipitation is accumulated in several temporal windows: 1 day, 2 days, 3 days, 5 days and 10 days. The 4 most extreme events in each category and season are selected, leading to a total of 336 days to be simulated. The simulated events are affected by systematic biases that have to be accounted before this data set can be used as input in hydrological models. Thus, quantile mapping is used to remove such biases. For this task

Run 16, eIPM Summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Connolly, R.; Dawson, C.; Jao, S.

2016-08-05

Three problems with the eIPMs were corrected during the 2015 summer shutdown. These involved ac coupling and 'negative profiles', detector 'dead zone' created by biasing, and gain control on ramp. With respect to Run 16, problems dealt with included gain depletion on horizontal MCP and rf pickup on profile signals; it was found that the MCP was severely damaged over part of the aperture. Various corrective measures were applied. Some results of these measured obtained during Run 16 are shown. At the end of Run 16 there was a three-­day beam run to study polarized proton beams in the AGS.more » Attempts to minimize beam injection errors which increase emittance by using the eIPMs to measure the contribution of injection mismatch to the AGS output beam emittance are recounted. .« less

Relaxing the rule of ten events per variable in logistic and Cox regression.

PubMed

Vittinghoff, Eric; McCulloch, Charles E

2007-03-15

The rule of thumb that logistic and Cox models should be used with a minimum of 10 outcome events per predictor variable (EPV), based on two simulation studies, may be too conservative. The authors conducted a large simulation study of other influences on confidence interval coverage, type I error, relative bias, and other model performance measures. They found a range of circumstances in which coverage and bias were within acceptable levels despite less than 10 EPV, as well as other factors that were as influential as or more influential than EPV. They conclude that this rule can be relaxed, in particular for sensitivity analyses undertaken to demonstrate adequate control of confounding.

Adverse Space Weather at the Solar Cycle Minimum

NASA Astrophysics Data System (ADS)

Baker, D. N.; Kanekal, S. G.; McCollough, J. P.; Singer, H. J.; Chappell, S. P.; Allen, J. H.

2008-05-01

It is commonly understood that many types of adverse space weather (solar flares, coronal mass ejections, geomagnetic storms) occur most commonly around the maximum of the 11-year sunspot activity cycle. Other types of well-known space weather such as relativistic electron events in the Earth's outer magnetosphere (that produce deep dielectric charging in spacecraft systems) are usually associated with the period just after sunspot maximum. At the present time, we are in the very lowest activity phase of the sunspot cycle (solar minimum). As such we would not expect much in the way of adverse space weather events. However, in early to mid-February of 2008 quite prominent solar coronal holes produced two high-speed streams that in turn stimulated very large, long-duration relativistic electron enhancements in Earth's magnetosphere. These seem to have been associated with several spacecraft operational anomalies at various spacecraft orbital locations. We describe these recent space weather events and assess their operational significance in this presentation. These results show that substantial space weather events can and do occur even during the quietest parts of the solar cycle.

The Battle over Studies of Faculty Bias

ERIC Educational Resources Information Center

Gravois, John

2007-01-01

The American Federation of Teachers (AFT) recently commissioned a study to review the research that finds liberal bias run amok in academe. Believing that the AFT is not a dispassionate observer of this debate, this article provides "The Chronicle of Higher Education's" survey of the genre. The studies reviewed include: (1) "Political Bias in the…

Can Service Learning Reinforce Social and Cultural Bias? Exploring a Popular Model of Family Involvement for Early Childhood Teacher Candidates

ERIC Educational Resources Information Center

Dunn-Kenney, Maylan

2010-01-01

Service learning is often used in teacher education as a way to challenge social bias and provide teacher candidates with skills needed to work in partnership with diverse families. Although some literature suggests that service learning could reinforce cultural bias, there is little documentation. In a study of 21 early childhood teacher…

Positive valence bias and parent-child relationship security moderate the association between early institutional caregiving and internalizing symptoms.

PubMed

Vantieghem, Michelle R; Gabard-Durnam, Laurel; Goff, Bonnie; Flannery, Jessica; Humphreys, Kathryn L; Telzer, Eva H; Caldera, Christina; Louie, Jennifer Y; Shapiro, Mor; Bolger, Niall; Tottenham, Nim

2017-05-01

Institutional caregiving is associated with significant deviations from species-expected caregiving, altering the normative sequence of attachment formation and placing children at risk for long-term emotional difficulties. However, little is known about factors that can promote resilience following early institutional caregiving. In the current study, we investigated how adaptations in affective processing (i.e., positive valence bias) and family-level protective factors (i.e., secure parent-child relationships) moderate risk for internalizing symptoms in previously institutionalized (PI) youth. Children and adolescents with and without a history of institutional care performed a laboratory-based affective processing task and self-reported measures of parent-child relationship security. PI youth were more likely than comparison youth to show positive valence biases when interpreting ambiguous facial expressions. Both positive valence bias and parent-child relationship security moderated the association between institutional care and parent-reported internalizing symptoms, such that greater positive valence bias and more secure parent-child relationships predicted fewer symptoms in PI youth. However, when both factors were tested concurrently, parent-child relationship security more strongly moderated the link between PI status and internalizing symptoms. These findings suggest that both individual-level adaptations in affective processing and family-level factors of secure parent-child relationships may ameliorate risk for internalizing psychopathology following early institutional caregiving.

Arousal-biased competition in perception and memory

PubMed Central

Mather, Mara; Sutherland, Matthew R.

2010-01-01

Our everyday surroundings besiege us with information. The battle is for a share of our limited attention and memory, with the brain selecting the winners and discarding the losers. Previous research shows that both bottom-up and top-down factors bias competition in favor of high priority stimuli. We propose that arousal during an event increases this bias both in perception and in long-term memory of the event. Arousal-biased competition theory provides specific predictions about when arousal will enhance and when it will impair memory for events, accounting for some puzzling contradictions in the emotional memory literature. PMID:21660127

BIAS: Bioinformatics Integrated Application Software.

PubMed

Finak, G; Godin, N; Hallett, M; Pepin, F; Rajabi, Z; Srivastava, V; Tang, Z

2005-04-15

We introduce a development platform especially tailored to Bioinformatics research and software development. BIAS (Bioinformatics Integrated Application Software) provides the tools necessary for carrying out integrative Bioinformatics research requiring multiple datasets and analysis tools. It follows an object-relational strategy for providing persistent objects, allows third-party tools to be easily incorporated within the system and supports standards and data-exchange protocols common to Bioinformatics. BIAS is an OpenSource project and is freely available to all interested users at http://www.mcb.mcgill.ca/~bias/. This website also contains a paper containing a more detailed description of BIAS and a sample implementation of a Bayesian network approach for the simultaneous prediction of gene regulation events and of mRNA expression from combinations of gene regulation events. hallett@mcb.mcgill.ca.

Developing interpretation bias modification as a "cognitive vaccine" for depressed mood: imagining positive events makes you feel better than thinking about them verbally.

PubMed

Holmes, Emily A; Lang, Tamara J; Shah, Dhruvi M

2009-02-01

Two interpretation bias modification experiments found that mental imagery vs. verbal processing of positive material have differential emotional effects. In Experiment 1, participants were instructed to imagine positively resolved auditory descriptions or to listen to the same events while thinking about their verbal meaning. Increases in positive mood and bias were greater in the imagery than in the verbal condition, replicating E. A. Holmes, A. Mathews, T. Dalgleish, and B. Mackintosh (2006). An emotional vulnerability test showed that imagery (relative to the verbal condition) protected against a later negative mood induction. Experiment 2 created 2 new verbal conditions aimed to increase or reduce verbal comparisons. Results suggest making unfavorable comparisons with the highly positive material might be partially responsible for the inferiority of the verbal condition in Experiment 1. The findings demonstrate that imagery can play a key role in cognitive bias modification procedures and thus that task instructions are crucial. Imagining a positive event can make you feel better than thinking about the same event verbally. The authors propose that recruiting imagery will be useful in therapeutic innovations to develop a "cognitive vaccine" for depressed mood.

Health and economic burden of running-related injuries in runners training for an event: A prospective cohort study.

PubMed

Hespanhol Junior, L C; van Mechelen, W; Postuma, E; Verhagen, E

2016-09-01

Prospective running-related injury (RRI) data from runners training for an event are scarce, especially with regard to RRI-associated costs. Therefore, the aim of this study was to investigate the prevalence and economic burden of RRIs in runners participating in an organized training program preparing them for an event. This was a prospective cohort study with 18 weeks of follow-up. Individuals aged 18 or older and registered to participate in an organized running program were eligible. Follow-up surveys were sent every 2 weeks to collect data about running exposure, RRIs, and costs. Of the 161 potential participants, 53 (32.9%) were included in this study. A total of 32 participants reported 41 RRIs. The mean prevalence during follow-up was 30.8% [95% confidence interval (CI) 25.6-36.0%]. Overuse was the main mechanism of RRI (85.4%, n = 35). An RRI was estimated to have an economic burden of €57.97 (95% CI €26.17-94.00) due to healthcare utilization (direct costs) and €115.75 (95% CI €10.37-253.73) due to absenteeism from paid work (indirect costs). These results indicate that the health and economic burden of RRIs may be considered significant for public health. Therefore, prevention programs are needed for runners participating in organized training programs. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Running Records: Authentic Instruction in Early Childhood Education

ERIC Educational Resources Information Center

Shea, Mary

2012-01-01

The most effective way to understand what a child knows about the reading process is to take a running record. In "Running Records", Mary Shea demonstrates how teachers can use this powerful tool to design lessons that decrease reading difficulties, build on strengths, and stimulate motivation, ensuring that children develop self-sustaining…

Stimulus-driven attention, threat bias, and sad bias in youth with a history of an anxiety disorder or depression

PubMed Central

Sylvester, Chad M.; Hudziak, James J.; Gaffrey, Michael S.; Barch, Deanna M.; Luby, Joan L.

2015-01-01

Attention biases towards threatening and sad stimuli are associated with pediatric anxiety and depression, respectively. The basic cognitive mechanisms associated with attention biases in youth, however, remain unclear. Here, we tested the hypothesis that threat bias (selective attention for threatening versus neutral stimuli) but not sad bias relies on stimulus-driven attention. We collected measures of stimulus-driven attention, threat bias, sad bias, and current clinical symptoms in youth with a history of an anxiety disorder and/or depression (ANX/DEP; n=40) as well as healthy controls (HC; n=33). Stimulus-driven attention was measured with a non-emotional spatial orienting task, while threat bias and sad bias were measured at a short time interval (150 ms) with a spatial orienting task using emotional faces and at a longer time interval (500 ms) using a dot-probe task. In ANX/DEP but not HC, early attention bias towards threat was negatively correlated with later attention bias to threat, suggesting that early threat vigilance was associated with later threat avoidance. Across all subjects, stimulus-driven orienting was not correlated with early threat bias but was negatively correlated with later threat bias, indicating that rapid stimulus-driven orienting is linked to later threat avoidance. No parallel relationships were detected for sad bias. Current symptoms of depression but not anxiety were related to decreased stimulus-driven attention. Together, these results are consistent with the hypothesis that threat bias but not sad bias relies on stimulus-driven attention. These results inform the design of attention bias modification programs that aim to reverse threat biases and reduce symptoms associated with pediatric anxiety and depression. PMID:25702927

Stimulus-Driven Attention, Threat Bias, and Sad Bias in Youth with a History of an Anxiety Disorder or Depression.

PubMed

Sylvester, Chad M; Hudziak, James J; Gaffrey, Michael S; Barch, Deanna M; Luby, Joan L

2016-02-01

Attention biases towards threatening and sad stimuli are associated with pediatric anxiety and depression, respectively. The basic cognitive mechanisms associated with attention biases in youth, however, remain unclear. Here, we tested the hypothesis that threat bias (selective attention for threatening versus neutral stimuli) but not sad bias relies on stimulus-driven attention. We collected measures of stimulus-driven attention, threat bias, sad bias, and current clinical symptoms in youth with a history of an anxiety disorder and/or depression (ANX/DEP; n = 40) as well as healthy controls (HC; n = 33). Stimulus-driven attention was measured with a non-emotional spatial orienting task, while threat bias and sad bias were measured at a short time interval (150 ms) with a spatial orienting task using emotional faces and at a longer time interval (500 ms) using a dot-probe task. In ANX/DEP but not HC, early attention bias towards threat was negatively correlated with later attention bias to threat, suggesting that early threat vigilance was associated with later threat avoidance. Across all subjects, stimulus-driven orienting was not correlated with early threat bias but was negatively correlated with later threat bias, indicating that rapid stimulus-driven orienting is linked to later threat avoidance. No parallel relationships were detected for sad bias. Current symptoms of depression but not anxiety were related to decreased stimulus-driven attention. Together, these results are consistent with the hypothesis that threat bias but not sad bias relies on stimulus-driven attention. These results inform the design of attention bias modification programs that aim to reverse threat biases and reduce symptoms associated with pediatric anxiety and depression.

The own-age bias in face memory is unrelated to differences in attention--evidence from event-related potentials.

PubMed

Neumann, Markus F; End, Albert; Luttmann, Stefanie; Schweinberger, Stefan R; Wiese, Holger

2015-03-01

Participants are more accurate at remembering faces from their own relative to a different age group (the own-age bias, or OAB). A recent socio-cognitive account has suggested that differential allocation of attention to old versus young faces underlies this phenomenon. Critically, empirical evidence for a direct relationship between attention to own- versus other-age faces and the OAB in memory is lacking. To fill this gap, we tested the roles of attention in three different experimental paradigms, and additionally analyzed event-related brain potentials (ERPs). In Experiment 1, we compared the learning of old and young faces during focused versus divided attention, but revealed similar OABs in subsequent memory for both attention conditions. Similarly, manipulating attention during learning did not differentially affect the ERPs elicited by young versus old faces. In Experiment 2, we examined the repetition effects from task-irrelevant old and young faces presented under varying attentional loads on the N250r ERP component as an index of face recognition. Independent of load, the N250r effects were comparable for both age categories. Finally, in Experiment 3 we measured the N2pc as an index of attentional selection of old versus young target faces in a visual search task. The N2pc was not significantly different for the young versus the old target search conditions, suggesting similar orientations of attention to either face age group. Overall, we propose that the OAB in memory is largely unrelated to early attentional processes. Our findings therefore contrast with the predictions from socio-cognitive accounts on own-group biases in recognition memory, and are more easily reconciled with expertise-based models.

Positive valence bias and parent-child relationship security moderate the association between early institutional caregiving and internalizing symptoms

PubMed Central

VanTieghem, Michelle R.; Gabard-Durnam, Laurel; Goff, Bonnie; Flannery, Jessica; Humphreys, Kathryn L.; Telzer, Eva H.; Caldera, Christina; Louie, Jennifer Y.; Shapiro, Mor; Bolger, Niall; Tottenham, Nim

2018-01-01

Institutional caregiving is associated with significant deviations from species-expected caregiving, altering the normative sequence of attachment formation and placing children at risk for long-term emotional difficulties. However, little is known about factors that can promote resilience following early institutional caregiving. In the current study, we investigated how adaptations in affective processing (i.e. positive valence bias) and family-level protective factors (i.e. secure parent-child relationships) moderate risk for internalizing symptoms in Previously Institutionalized (PI) youth. Children and adolescents with and without a history of institutional care performed a laboratory-based affective processing task and self-reported measures of parent-child relationship security. PI youth were more likely than comparison youth to show positive valence biases when interpreting ambiguous facial expressions. Both positive valence bias and parent-child relationship security moderated the association between institutional care and parent-reported internalizing symptoms, such that greater positive valence bias and more secure parent-child relationships predicted fewer symptoms in PI youth. However, when both factors were tested concurrently, parent-child relationship security more strongly moderated the link between PI status and internalizing symptoms. These findings suggest that both individual-level adaptations in affective processing and family-level factors of secure parent-child relationships may ameliorate risk for internalizing psychopathology following early institutional caregiving. PMID:28401841

Transport of plutonium in snowmelt run-off

DOE Office of Scientific and Technical Information (OSTI.GOV)

Purtymun, W.D.; Peters, R.; Maes, M.N.

1990-07-01

Plutonium in treated low-level radioactive effluents released into intermittent streams is bound by ion exchange or adsorption to bed sediments in the stream channel. These sediments are subject to transport with summer and spring snowmelt run-off. A study was made of the transport of plutonium during seven spring run-off events in Los Alamos and Pueblo canyons from the Laboratory boundary to Otowi on the Rio Grande. The melting of the snowpack during these years resulted in run-off that was large enough to reach the eastern edge of the Laboratory. Of these seven run-off events recorded at the Laboratory boundary, onlymore » five had sufficient flow to reach the Rio Grande. The volume of the five events that reached the river ranged from 5 {times} 10{sup 3} m{sup 3} to 104 {times} 10{sup 3} m{sup 3}. The five run-off events carried 119 {times} 10{sup 3} kg of suspended sediments and 1073 {times} 10{sup 3} kg of bed sediments, and transported 598 {mu}Ci of plutonium to the river. Of the 598 {mu}Ci of plutonium, 3% was transported in solution, 57% with suspended sediments, and 40% with bed sediments. 13 refs., 3 figs., 6 tabs.« less

Solar Minimum

NASA Astrophysics Data System (ADS)

Lopresto, James C.; Mathews, John; Manross, Kevin

1995-12-01

Calcium K plage, H alpha plage and sunspot area have been monitored daily on the INTERNET since November of 1992. The plage and sunspot area have been measured by image processing. The purpose of the project is to investigate the degree of correlation between plage area and solar irradiance. The plage variation shows the expected variation produced by solar rotation and the longer secular changes produced by the solar cycle. The H alpha and sunspot plage area reached a minimum in about late 1994 or early 1995. This is in agreement with the K2 spectral index obtained daily from Sacramento Peak Observatory. The Calcium K plage area minimum seems delayed with respect to the others mentioned above. The minimum of the K line plage area is projected to come within the last few months of 1995.

29 CFR 4043.33 - Application for minimum funding waiver.

Code of Federal Regulations, 2011 CFR

2011-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.33 Application for minimum funding waiver. (a) Reportable event. A reportable event for a...

29 CFR 4043.33 - Application for minimum funding waiver.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.33 Application for minimum funding waiver. (a) Reportable event. A reportable event for a...

29 CFR 4043.33 - Application for minimum funding waiver.

Code of Federal Regulations, 2014 CFR

2014-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.33 Application for minimum funding waiver. (a) Reportable event. A reportable event for a...

29 CFR 4043.33 - Application for minimum funding waiver.

Code of Federal Regulations, 2012 CFR

2012-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.33 Application for minimum funding waiver. (a) Reportable event. A reportable event for a...

29 CFR 4043.33 - Application for minimum funding waiver.

Code of Federal Regulations, 2013 CFR

2013-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.33 Application for minimum funding waiver. (a) Reportable event. A reportable event for a...

30 CFR 1202.352 - Minimum royalty.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Minimum royalty. 1202.352 Section 1202.352 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE ROYALTIES Geothermal Resources § 1202.352 Minimum royalty. In no event shall the lessee's annual...

30 CFR 1202.352 - Minimum royalty.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Minimum royalty. 1202.352 Section 1202.352 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE ROYALTIES Geothermal Resources § 1202.352 Minimum royalty. In no event shall the lessee's annual...

30 CFR 1202.352 - Minimum royalty.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Minimum royalty. 1202.352 Section 1202.352 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE ROYALTIES Geothermal Resources § 1202.352 Minimum royalty. In no event shall the lessee's annual...

30 CFR 202.352 - Minimum royalty.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Minimum royalty. 202.352 Section 202.352 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ROYALTIES Geothermal Resources § 202.352 Minimum royalty. In no event shall the lessee's annual royalty...

A catastrophic event in Lake Geneva region during the Early Bronze Age?

NASA Astrophysics Data System (ADS)

Kremer, Katrina; Yrro, Blé; Marillier, François; Hilbe, Michael; Corboud, Pierre; Rachoud-Schneider, Anne-Marie; Girardclos, Stéphanie

2013-04-01

Similarly to steep oceanic continental margins, lake slopes can collapse, producing large sublacustrine landslides and tsunamis. Lake sediments are excellent natural archives of such mass movements and their study allows the reconstructions of these prehistoric events, such as the 563 AD large tsunami over Lake Geneva (Kremer et al, 2012). In Lake Geneva, more than 100 km of high-resolution seismic reflection profiles reveal the late Holocene sedimentation history. The seismic record shows a succession of five large lens-shaped seismic units (A to I), characterized by transparent/chaotic seismic facies with irregular lower boundaries, and interpreted as mass-movement deposits. These units are interbedded with parallel, continuous and strong amplitude reflections, interpreted as the 'background' lake sediments. The oldest dated mass movement (Unit D) covers a surface of 22 km2 in the deep basin, near the city of Lausanne. This deposit has an estimated minimum volume of 0.18 km3 and thus was very likely tsunamigenic (Kremer et al, 2012). A 12-m-long sediment core confirms the seismic interpretation of the mass movement unit and shows that the uppermost 3 m of Unit D are characterized by deformed hemipelagic sediments topped by a 5 cm thick turbidite. This deposit can be classified as a slump whose scar can be interpreted in the seismic data and visualized by multibeam bathymetry. This slump of Lausanne was likely triggered by an earthquake but a spontaneous slope collapse cannot be excluded (Girardclos et al, 2007). Radiocarbon dating of plant macro-remains reveals that the unit D happened during Early Bronze Age. Three other mass wasting deposits occurred during the same time period and may have been triggered during the same event, either by a single earthquake or by a tsunami generated by the slump of Lausanne. Although the exact trigger mechanism of the all these mass-wasting deposits remains unknown, a tsunami likely generated by this event may have affected the

Bovid mortality profiles in paleoecological context falsify hypotheses of endurance running-hunting and passive scavenging by early Pleistocene hominins

NASA Astrophysics Data System (ADS)

Bunn, Henry T.; Pickering, Travis Rayne

2010-11-01

The world's first archaeological traces from 2.6 million years ago (Ma) at Gona, in Ethiopia, include sharp-edged cutting tools and cut-marked animal bones, which indicate consumption of skeletal muscle by early hominin butchers. From that point, evidence of hominin meat-eating becomes increasingly more common throughout the Pleistocene archaeological record. Thus, the substantive debate about hominin meat-eating now centers on mode(s) of carcass resource acquisition. Two prominent hypotheses suggest, alternatively, (1) that early Homo hunted ungulate prey by running them to physiological failure and then dispatching them, or (2) that early Homo was relegated to passively scavenging carcass residues abandoned by carnivore predators. Various paleontologically testable predictions can be formulated for both hypotheses. Here we test four predictions concerning age-frequency distributions for bovids that contributed carcass remains to the 1.8 Ma. old FLK 22 Zinjanthropus (FLK Zinj, Olduvai Gorge, Tanzania) fauna, which zooarchaeological and taphonomic data indicate was formed predominantly by early Homo. In all but one case, the bovid mortality data from FLK Zinj violate test predictions of the endurance running-hunting and passive scavenging hypotheses. When combined with other taphonomic data, these results falsify both hypotheses, and lead to the hypothesis that early Homo operated successfully as an ambush predator.

Prediction of the run out extents of the Slano Blato landslide for future debris flow events

NASA Astrophysics Data System (ADS)

Askarinejad, Amin; Leu, Pascal; Macek, Matej; Petkovsek, Ana; Springman, Sarah

2013-04-01

The Slano Blato landslide has a volume of about 1 mio m3 and is located in the western part of Slovenia. It has been considered to be a potential natural hazard for the village of Lokavec for more than 200 years. Several mud flows, exhibiting a range of volumes and velocities, have originated from the landslide body since the year 2000, when the landslide was reactivated due to an intense rainfall event. A series of obstacles, including safety dams and deposition ponds, have been constructed for the remediation of the landslide. These obstacles are designed to absorb and contain future debris flow hazard. A prerequisite to any risk analysis is to establish the vulnerability to the hazard event. The aim of this work is to simulate possible future debris flow scenarios in order to predict the run out distances, flow heights, impact pressures and potential effects on the downstream village buildings and infrastructure. The simulations were carried out using the RAMMS program (RApid Mass MovementS, www.ramms.slf.ch). A three dimensional terrain model of the landslide area and the downstream zones, with or without the inclusion of the obstacles, was made for the simulations and different scenarios concerning the released volume, the internal friction and viscosity of the sliding mass were studied. The results indicate that low viscosity mudflows with a volume of 5,000 m3 endanger some parts of Lokavec village. However, the simulations with volumes of 15,000 and 50,000 m3 predict catastrophic effects in terms of either impact pressures or deposition heights for the majority of houses. Moreover, the simulations confirmed that the choice of the material properties (internal friction and viscosity), the characteristics of the release hydrograph, event location, and natural or man-made obstacles play major roles in the run out distances and impact pressures.

The ALICE TPC Upgrad

NASA Astrophysics Data System (ADS)

Castro, Andrew; Alice-Usa Collaboration; Alice-Tpc Collaboration

2017-09-01

The Time Projection Chamber (TPC) currently used for ALICE (A Large Ion Collider Experiment at CERN) is a gaseous tracking detector used to study both proton-proton and heavy-ion collisions at the Large Hadron Collider (LHC) In order to accommodate the higher luminosit collisions planned for the LHC Run-3 starting in 2021, the ALICE-TPC will undergo a major upgrade during the next LHC shut down. The TPC is limited to a read out of 1000 Hz in minimum bias events due to the intrinsic dead time associated with back ion flow in the multi wire proportional chambers (MWPC) in the TPC. The TPC upgrade will handle the increase in event readout to 50 kHz for heavy ion minimum bias triggered events expected with the Run-3 luminosity by switching the MWPCs to a stack of four Gaseous Electron Multiplier (GEM) foils. The GEM layers will combine different hole pitches to reduce the dead time while maintaining the current spatial and energy resolution of the existing TPC. Undertaking the upgrade of the TPC represents a massive endeavor in terms of design, production, construction, quality assurance, and installation, thus the upgrade is coordinated over a number of institutes worldwide. The talk will go over the physics motivation for the upgrade, the ALICE-USA contribution to the construction of Inner Read Out Chambers IROCs, and QA from the first chambers built in the U.S

Expectancy bias mediates the link between social anxiety and memory bias for social evaluation

PubMed Central

Caouette, Justin D.; Ruiz, Sarah K.; Lee, Clinton C.; Anbari, Zainab; Schriber, Roberta A.; Guyer, Amanda E.

2014-01-01

Social anxiety (SA) involves a multitude of cognitive symptoms related to fear of evaluation, including expectancy and memory biases. We examined whether memory biases are influenced by expectancy biases for social feedback in SA. We hypothesized that, faced with a socially evaluative event, people with higher SA would show a negative expectancy bias for future feedback. Furthermore, we predicted that memory bias for feedback in SA would be mediated by expectancy bias. Ninety-four undergraduate students (55 women, mean age = 19.76 years) underwent a two-visit task that measured expectations about (Visit 1) and memory of (Visit 2) feedback from unknown peers. Results showed that higher levels of SA were associated with negative expectancy bias. An indirect relationship was found between SA and memory bias that was mediated by expectancy bias. The results suggest that expectancy biases are in the causal path from SA to negative memory biases for social evaluation. PMID:25252925

Implicit learning of sequential bias in a guessing task: failure to demonstrate effects of dopamine administration and paranormal belief.

PubMed

Palmer, John; Mohr, Christine; Krummenacher, Peter; Brugger, Peter

2007-06-01

Previous research suggests that implicit sequence learning (ISL) is superior for believers in the paranormal and individuals with increased cerebral dopamine. Thirty-five healthy participants performed feedback-guided anticipations of four arrow directions. A 100-trial random sequence preceded two 100-trial biased sequences in which visual targets (arrows) on trial t tended to be displaced 90 degrees clockwise (CW) or counter-clockwise (CCW) from those on t - 1. ISL was defined as a positive change during the course of the biased run in the difference between pro-bias and counter-bias responses. It was hypothesized that this difference would be greater for believers in the paranormal than for skeptics, for those who received dopamine than for those who received placebo, and for believers who received dopamine than for the other groups. None of the hypotheses were supported by the data. It is suggested that a simple binary guessing task with a focus on prediction accuracy during early trials should be considered for future explorations.

Threat-Related Attention Bias Variability and Posttraumatic Stress.

PubMed

Naim, Reut; Abend, Rany; Wald, Ilan; Eldar, Sharon; Levi, Ofir; Fruchter, Eyal; Ginat, Karen; Halpern, Pinchas; Sipos, Maurice L; Adler, Amy B; Bliese, Paul D; Quartana, Phillip J; Pine, Daniel S; Bar-Haim, Yair

2015-12-01

Threat monitoring facilitates survival by allowing one to efficiently and accurately detect potential threats. Traumatic events can disrupt healthy threat monitoring, inducing biased and unstable threat-related attention deployment. Recent research suggests that greater attention bias variability, that is, attention fluctuations alternating toward and away from threat, occurs in participants with PTSD relative to healthy comparison subjects who were either exposed or not exposed to traumatic events. The current study extends findings on attention bias variability in PTSD. Previous measurement of attention bias variability was refined by employing a moving average technique. Analyses were conducted across seven independent data sets; in each, data on attention bias variability were collected by using variants of the dot-probe task. Trauma-related and anxiety symptoms were evaluated across samples by using structured psychiatric interviews and widely used self-report questionnaires, as specified for each sample. Analyses revealed consistent evidence of greater attention bias variability in patients with PTSD following various types of traumatic events than in healthy participants, participants with social anxiety disorder, and participants with acute stress disorder. Moreover, threat-related, and not positive, attention bias variability was correlated with PTSD severity. These findings carry possibilities for using attention bias variability as a specific cognitive marker of PTSD and for tailoring protocols for attention bias modification for this disorder.

Stressful Life Events, ADHD Symptoms, and Brain Structure in Early Adolescence.

PubMed

Humphreys, Kathryn L; Watts, Emily L; Dennis, Emily L; King, Lucy S; Thompson, Paul M; Gotlib, Ian H

2018-05-21

Despite a growing understanding that early adversity in childhood broadly affects risk for psychopathology, the contribution of stressful life events to the development of symptoms of attention-deficit/hyperactivity disorder (ADHD) is not clear. In the present study, we examined the association between number of stressful life events experienced and ADHD symptoms, assessed using the Attention Problems subscale of the Child Behavior Checklist, in a sample of 214 children (43% male) ages 9.11-13.98 years (M = 11.38, SD = 1.05). In addition, we examined whether the timing of the events (i.e., onset through age 5 years or after age 6 years) was associated with ADHD symptoms. Finally, we examined variation in brain structure to determine whether stressful life events were associated with volume in brain regions that were found to vary as a function of symptoms of ADHD. We found a small to moderate association between number of stressful life events and ADHD symptoms. Although the strength of the associations between number of events and ADHD symptoms did not differ as a function of the age of occurrence of stressful experiences, different brain regions were implicated in the association between stressors and ADHD symptoms in the two age periods during which stressful life events occurred. These findings support the hypothesis that early adversity is associated with ADHD symptoms, and provide insight into possible brain-based mediators of this association.

Explication of Interspousal Criticality Bias

PubMed Central

Peterson, Kristina M.; Smith, David A.; Windle, Chaunce R.

2009-01-01

Although bias towards perceiving spousal criticism is related to dysphoria and marital discord (Smith & Peterson, 2008), the bias construct has received insufficient elaboration. We explicated the criticality bias construct by exploring its correlates and incremental validity relative to perceived criticism, marital attributions, and negative affect. 118 couples completed self-report measures and undertook a videotaped discussion task. Signal detection analyses of both spouses’ and outside observers’ ratings of discussions produced bias indices. Criticality bias evidenced a pattern of convergent and discriminant validity mirroring perceived criticism’s (Renshaw, 2008). Bias also provided incremental validity beyond perceived criticism, marital attributions, and negative affect to the prediction of behavior. Bias may be a dysfunctional way to view marital events and a stress generation process. PMID:19286167

Paleomagnetic and Geochronologic Data from Central Asia: Inferences for Early Paleozoic Tectonic Evolution and Timing of Worldwide Glacial Events

NASA Astrophysics Data System (ADS)

Gregory, L. C.; Meert, J. G.; Levashova, N.; Grice, W. C.; Gibsher, A.; Rybanin, A.

2007-12-01

The Neoproterozoic to early Paleozoic Ural-Mongol belt that runs through Central Asia is crucial for determining the enigmatic amalgamation of microcontinents that make up the Eurasian subcontinent. Two unique models have been proposed for the evolution of Ural-Mongol belt. One involves a complex assemblage of cratonic blocks that have collided and rifted apart during diachronous opening and closing of Neoproterozoic to Devonian aged ocean basins. The opposing model of Sengor and Natal"in proposes a long-standing volcanic arc system that connected Central Asian blocks with the Baltica continent. The Aktau-Mointy and Dzabkhan microcontinents in Kazakhstan and Central Mongolia make up the central section of the Ural-Mongol belt, and both contain glacial sequences characteristic of the hypothesized snowball earth event. These worldwide glaciations are currently under considerable debate, and paleomagnetic data from these microcontients are a useful contribution to the snowball controversy. We have sampled volcanic and sedimentary sequences in Central Mongolia, Kazakhstan and Kyrgyzstan for paleomagnetic and geochronologic study. U-Pb data, 13C curves and abundant fossil records place age constraints on sequences that contain glacial deposits of the hypothesized snowball earth events. Carbonates in the Zavkhan Basin in Mongolia are likely remagnetized, but fossil evidence within the sequence suggests a readjusted age control on two glacial events that were previously labeled as Sturtian and Marinoan. U-Pb ages from both Kazakhstan and Mongolian volcanic sequences imply a similar evolution history of the areas as part of the Ural-Mongol fold belt, and these ages paired with paleomagnetic and 13C records have important tectonic implications. We will present these data in order to place better constraints on the Precambrian to early Paleozoic tectonic evolution of Central Asia and the timing of glacial events recorded in the area.

Characteristics of low-speed vehicle run-over events in children: an 11-year review.

PubMed

Griffin, Bronwyn R; Watt, Kerrianne; Shields, Linda E; Kimble, Roy M

2014-10-01

The purpose of this study was to investigate the characteristics associated with fatal and non-fatal low-speed vehicle run-over (LSVRO) events in relation to person, incident and injury characteristics, in order to identify appropriate points for intervention and injury prevention. Data on all known LSVRO events in Queensland, Australia, over 11 calendar years (1999-2009) were extracted from five different databases representing the continuum of care (prehospital to fatality) and manually linked. Descriptive and multivariate analyses were used to analyse the sample characteristics in relation to demographics, health service usage, outcomes, incident characteristics, and injury characteristics. Of the 1641 LSVRO incidents, 98.4% (n=1615) were non-fatal, and 1.6% were fatal (n=26). Over half the children required admission to hospital (56%, n=921); mean length of stay was 3.4 days. Younger children aged 0-4 years were more frequently injured, and experienced more serious injuries with worse outcomes. Patterns of injury (injury type and severity), injury characteristics (eg, time of injury, vehicle type, driver of vehicle, incident location), and demographic characteristics (such as socioeconomic status, indigenous status, remoteness), varied according to age group. Almost half (45.6%; n=737) the events occurred outside major cities, and approximately 10% of events involved indigenous children. Parents were most commonly the vehicle drivers in fatal incidents. While larger vehicles such as four-wheel drives (4WD) were most frequently involved in LSVRO events resulting in fatalities, cars were most frequently involved in non-fatal events. This is the first study, to the authors' knowledge, to analyse the characteristics of fatal and non-fatal LSVRO events in children aged 0-15 years on a state-wide basis. Characteristics of LSVRO events varied with age, thus age-specific interventions are required. Children living outside major cities, and indigenous children

Running Technique is an Important Component of Running Economy and Performance

PubMed Central

FOLLAND, JONATHAN P.; ALLEN, SAM J.; BLACK, MATTHEW I.; HANDSAKER, JOSEPH C.; FORRESTER, STEPHANIE E.

2017-01-01

ABSTRACT Despite an intuitive relationship between technique and both running economy (RE) and performance, and the diverse techniques used by runners to achieve forward locomotion, the objective importance of overall technique and the key components therein remain to be elucidated. Purpose This study aimed to determine the relationship between individual and combined kinematic measures of technique with both RE and performance. Methods Ninety-seven endurance runners (47 females) of diverse competitive standards performed a discontinuous protocol of incremental treadmill running (4-min stages, 1-km·h−1 increments). Measurements included three-dimensional full-body kinematics, respiratory gases to determine energy cost, and velocity of lactate turn point. Five categories of kinematic measures (vertical oscillation, braking, posture, stride parameters, and lower limb angles) and locomotory energy cost (LEc) were averaged across 10–12 km·h−1 (the highest common velocity < velocity of lactate turn point). Performance was measured as season's best (SB) time converted to a sex-specific z-score. Results Numerous kinematic variables were correlated with RE and performance (LEc, 19 variables; SB time, 11 variables). Regression analysis found three variables (pelvis vertical oscillation during ground contact normalized to height, minimum knee joint angle during ground contact, and minimum horizontal pelvis velocity) explained 39% of LEc variability. In addition, four variables (minimum horizontal pelvis velocity, shank touchdown angle, duty factor, and trunk forward lean) combined to explain 31% of the variability in performance (SB time). Conclusions This study provides novel and robust evidence that technique explains a substantial proportion of the variance in RE and performance. We recommend that runners and coaches are attentive to specific aspects of stride parameters and lower limb angles in part to optimize pelvis movement, and ultimately enhance performance

New Perspectives on Long Run-out Rock Avalanches: A Dynamic Analysis of 20 Events in the Vaigat Strait, West Greenland

NASA Astrophysics Data System (ADS)

Benjamin, J.; Rosser, N. J.; Dunning, S.; Hardy, R. J.; Karim, K.; Szczucinski, W.; Norman, E. C.; Strzelecki, M.; Drewniak, M.

2014-12-01

Risk assessments of the threat posed by rock avalanches rely upon numerical modelling of potential run-out and spreading, and are contingent upon a thorough understanding of the flow dynamics inferred from deposits left by previous events. Few records exist of multiple rock avalanches with boundary conditions sufficiently consistent to develop a set of more generalised rules for behaviour across events. A unique cluster of 20 large (3 x 106 - 94 x 106 m3) rock avalanche deposits along the Vaigat Strait, West Greenland, offers a unique opportunity to model a large sample of adjacent events sourced from a stretch of coastal mountains of relatively uniform geology and structure. Our simulations of these events were performed using VolcFlow, a geophysical mass flow code developed to simulate volcanic debris avalanches. Rheological calibration of the model was performed using a well-constrained event at Paatuut (AD 2000). The best-fit simulation assumes a constant retarding stress with a collisional stress coefficient (T0 = 250 kPa, ξ = 0.01), and simulates run-out to within ±0.3% of that observed. Despite being widely used to simulate rock avalanche propagation, other models, that assume either a Coulomb frictional or a Voellmy rheology, failed to reproduce the observed event characteristics and deposit distribution at Paatuut. We applied this calibration to 19 other events, simulating rock avalanche motion across 3D terrain of varying levels of complexity. Our findings illustrate the utility and sensitivity of modelling a single rock avalanche satisfactorily as a function of rheology, alongside the validity of applying the same parameters elsewhere, even within similar boundary conditions. VolcFlow can plausibly account for the observed morphology of a series of deposits emplaced by events of different types, although its performance is sensitive to a range of topographic and geometric factors. These exercises show encouraging results in the model's ability to

Fandom Biases Retrospective Judgments Not Perception.

PubMed

Huff, Markus; Papenmeier, Frank; Maurer, Annika E; Meitz, Tino G K; Garsoffky, Bärbel; Schwan, Stephan

2017-02-24

Attitudes and motivations have been shown to affect the processing of visual input, indicating that observers may see a given situation each literally in a different way. Yet, in real-life, processing information in an unbiased manner is considered to be of high adaptive value. Attitudinal and motivational effects were found for attention, characterization, categorization, and memory. On the other hand, for dynamic real-life events, visual processing has been found to be highly synchronous among viewers. Thus, while in a seminal study fandom as a particularly strong case of attitudes did bias judgments of a sports event, it left the question open whether attitudes do bias prior processing stages. Here, we investigated influences of fandom during the live TV broadcasting of the 2013 UEFA-Champions-League Final regarding attention, event segmentation, immediate and delayed cued recall, as well as affect, memory confidence, and retrospective judgments. Even though we replicated biased retrospective judgments, we found that eye-movements, event segmentation, and cued recall were largely similar across both groups of fans. Our findings demonstrate that, while highly involving sports events are interpreted in a fan dependent way, at initial stages they are processed in an unbiased manner.

Fandom Biases Retrospective Judgments Not Perception

PubMed Central

Huff, Markus; Papenmeier, Frank; Maurer, Annika E.; Meitz, Tino G. K.; Garsoffky, Bärbel; Schwan, Stephan

2017-01-01

Attitudes and motivations have been shown to affect the processing of visual input, indicating that observers may see a given situation each literally in a different way. Yet, in real-life, processing information in an unbiased manner is considered to be of high adaptive value. Attitudinal and motivational effects were found for attention, characterization, categorization, and memory. On the other hand, for dynamic real-life events, visual processing has been found to be highly synchronous among viewers. Thus, while in a seminal study fandom as a particularly strong case of attitudes did bias judgments of a sports event, it left the question open whether attitudes do bias prior processing stages. Here, we investigated influences of fandom during the live TV broadcasting of the 2013 UEFA-Champions-League Final regarding attention, event segmentation, immediate and delayed cued recall, as well as affect, memory confidence, and retrospective judgments. Even though we replicated biased retrospective judgments, we found that eye-movements, event segmentation, and cued recall were largely similar across both groups of fans. Our findings demonstrate that, while highly involving sports events are interpreted in a fan dependent way, at initial stages they are processed in an unbiased manner. PMID:28233877

Incidental encoding of emotional pictures: affective bias studied through event related brain potentials.

PubMed

Tapia, Manuel; Carretié, Luis; Sierra, Benjamín; Mercado, Francisco

2008-06-01

Emotional stimuli are better remembered than neutral stimuli. Most of the studies taking into account this emotional bias refer to explicit memory, use behavioral measures of the recall and predict better recall of negative stimuli. The few studies taking into account implicit memory and the valence emotional dimension are inconclusive on the effect of the stimulus' emotional valence. In the present study, 120 pictures (30 positive, 30 negative, 30 relaxing and 30 neutral) were shown to, and assessed by, 28 participants (study phase). Subsequently, event related brain potentials (ERPs) were recorded during the presentation of 120 new (shown for the first time) and 120 old (already shown in the study phase) pictures (test phase). No explicit instructions or clues related to recovery were given to participants, and a distractor task was employed, in order to maintain implicit the memory assessment. As expected from other studies' data, our results showed that old stimuli elicited an enhanced late positive component 450 ms after stimulus onset (repetition effect). Moreover, this effect was modulated by the stimuli's emotional valence, since the most positively valenced stimuli were associated with a decreased repetition effect with respect to the most negatively valenced stimuli. This effect was located at ventromedial prefrontal cortex. These results suggest the existence of a valence-mediated bias in implicit memory.

Anti-Bias Education: Reflections

ERIC Educational Resources Information Center

Derman-Sparks, Louise

2011-01-01

It is 30 years since NAEYC published "Anti-Bias Curriculum Tools for Empowering Young Children" (Derman-Sparks & ABC Task Force, 1989). Since then, anti-bias education concepts have become part of the early childhood education (ECE) narrative in the United States and many other countries. It has brought a fresh way of thinking about…

Individuals With OCD Lack Unrealistic Optimism Bias in Threat Estimation.

PubMed

Zetsche, Ulrike; Rief, Winfried; Exner, Cornelia

2015-07-01

Overestimating the occurrence of threatening events has been highlighted as a central cognitive factor in the maintenance of obsessive-compulsive disorder (OCD). The present study examined the different facets of this cognitive bias, its underlying mechanisms, and its specificity to OCD. For this purpose, threat estimation, probabilistic classification learning (PCL) and psychopathological measures were assessed in 23 participants with OCD, 30 participants with social phobia, and 31 healthy controls. Whereas healthy participants showed an optimistic expectation bias regarding positive and negative future events, OCD participants lacked such a bias. This lack of an optimistic expectation bias was not specific to OCD. Compared to healthy controls, OCD participants overestimated their personal risk for experiencing negative events, but did not differ from controls in their risk estimation regarding other people. Finally, OCD participants' biases in the prediction of checking-related events were associated with their impairments in learning probabilistic cue-outcome associations in a disorder-relevant context. In sum, the present results add to a growing body of research demonstrating that cognitive biases in OCD are context-dependent. Copyright © 2015. Published by Elsevier Ltd.

Written threat: Electrophysiological evidence for an attention bias to affective words in social anxiety disorder.

PubMed

Wabnitz, Pascal; Martens, Ulla; Neuner, Frank

2016-01-01

Social anxiety disorder (SAD) is associated with heightened sensitivity to threat cues, typically represented by emotional facial expressions. To examine if this bias can be transferred to a general hypersensitivity or whether it is specific to disorder relevant cues, we investigated electrophysiological correlates of emotional word processing (alpha activity and event-related potentials) in 20 healthy participants and 20 participants with SAD. The experimental task was a silent reading of neutral, positive, physically threatening and socially threatening words (the latter were abusive swear words) while responding to a randomly presented dot. Subsequently, all participants were asked to recall as many words as possible during an unexpected recall test. Participants with SAD showed blunted sensory processing followed by a rapid processing of emotional words during early stages (early posterior negativity - EPN). At later stages, all participants showed enhanced processing of negative (physically and socially threatening) compared to neutral and positive words (N400). Moreover, at later processing stages alpha activity was increased specifically for negative words in participants with SAD but not in healthy controls. Recall of emotional words for all subjects was best for socially threatening words, followed by negative and positive words irrespective of social anxiety. The present findings indicate that SAD is associated with abnormalities in emotional word processing characterised by early hypervigilance to emotional cues followed by cognitive avoidance at later processing stages. Most importantly, the specificity of these attentional biases seems to change as a function of time with a general emotional bias at early and a more specific bias at later processing stages.

Abnormal early cleavage events predict early embryo demise: sperm oxidative stress and early abnormal cleavage.

PubMed

Burruel, Victoria; Klooster, Katie; Barker, Christopher M; Pera, Renee Reijo; Meyers, Stuart

2014-10-13

Human embryos resulting from abnormal early cleavage can result in aneuploidy and failure to develop normally to the blastocyst stage. The nature of paternal influence on early embryo development has not been directly demonstrated although many studies have suggested effects from spermatozoal chromatin packaging, DNA damage, centriolar and mitotic spindle integrity, and plasma membrane integrity. The goal of this study was to determine whether early developmental events were affected by oxidative damage to the fertilizing sperm. Survival analysis was used to compare patterns of blastocyst formation based on P2 duration. Kaplan-Meier survival curves demonstrate that relatively few embryos with short (<1 hr) P2 times reached blastocysts, and the two curves diverged beginning on day 4, with nearly all of the embryos with longer P2 times reaching blastocysts by day 6 (p < .01). We determined that duration of the 2nd to 3rd mitoses were sensitive periods in the presence of spermatozoal oxidative stress. Embryos that displayed either too long or too short cytokineses demonstrated an increased failure to reach blastocyst stage and therefore survive for further development. Although paternal-derived gene expression occurs later in development, this study suggests a specific role in early mitosis that is highly influenced by paternal factors.

Physiological and Biomechanical Mechanisms of Distance Specific Human Running Performance.

PubMed

Thompson, M A

2017-08-01

Running events range from 60-m sprints to ultra-marathons covering 100 miles or more, which presents an interesting diversity in terms of the parameters for successful performance. Here, we review the physiological and biomechanical variations underlying elite human running performance in sprint to ultramarathon distances. Maximal running speeds observed in sprint disciplines are achieved by high vertical ground reaction forces applied over short contact times. To create this high force output, sprint events rely heavily on anaerobic metabolism, as well as a high number and large cross-sectional area of type II fibers in the leg muscles. Middle distance running performance is characterized by intermediates of biomechanical and physiological parameters, with the possibility of unique combinations of each leading to high-level performance. The relatively fast velocities in mid-distance events require a high mechanical power output, though ground reaction forces are less than in sprinting. Elite mid-distance runners exhibit local muscle adaptations that, along with a large anaerobic capacity, provide the ability to generate a high power output. Aerobic capacity starts to become an important aspect of performance in middle distance events, especially as distance increases. In distance running events, V˙O2max is an important determinant of performance, but is relatively homogeneous in elite runners. V˙O2 and velocity at lactate threshold have been shown to be superior predictors of elite distance running performance. Ultramarathons are relatively new running events, as such, less is known about physiological and biomechanical parameters that underlie ultra-marathon performance. However, it is clear that performance in these events is related to aerobic capacity, fuel utilization, and fatigue resistance. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology 2017. This work is written by US Government employees and is in

Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm

PubMed Central

Gaur, Shailly; Mandelbaum, Max; Herold, Mona; Majumdar, Himani Datta; Neilson, Karen M.; Maynard, Thomas M.; Mood, Kathy; Daar, Ira O.; Moody, Sally A.

2016-01-01

The decision by embryonic ectoderm to give rise to epidermal versus neural derivatives is the result of signaling events during blastula and gastrula stages. However, there also is evidence in Xenopus that cleavage stage blastomeres contain maternally derived molecules that bias them toward a neural fate. We used a blastomere explant culture assay to test whether maternally deposited transcription factors bias 16-cell blastomere precursors of epidermal or neural ectoderm to express early zygotic neural genes in the absence of gastrulation interactions or exogenously supplied signaling factors. We found that Foxd4l1, Zic2, Gmnn and Sox11 each induced explants made from ventral, epidermis-producing blastomeres to express early neural genes, and that at least some of the Foxd4l1 and Zic2 activity is required at cleavage stages. Similarly, providing extra Foxd4l1 or Zic2 to explants made from dorsal, neural plate-producing blastomeres significantly increased expression of early neural genes, whereas knocking down either significantly reduced them. These results show that maternally delivered transcription factors bias cleavage stage blastomeres to a neural fate. We demonstrate that mouse and human homologues of Foxd4l1 have similar functional domains compared to the frog protein, as well as conserved transcriptional activities when expressed in Xenopus embryos and blastomere explants. PMID:27092474

Trait hostility and hostile interpretation biases in daily smokers: associations with reasons for smoking, motivation to quit, and early smoking lapse.

PubMed

Cougle, Jesse R; Hawkins, Kirsten A; Macatee, Richard J; Zvolensky, Michael J; Sarawgi, Shivali

2014-09-01

Hostility has emerged as an important predictor of smoking cessation difficulties, though the mechanisms underlying the hostility and smoking relationship are poorly understood. Further, research has yet to explore relations between hostile interpretation biases and different aspects of smoking behavior. In the present study, current daily smokers (N = 106) were administered measures of smoking characteristics, smoking motivation, reasons for quitting, hostility, and hostile interpretation bias. Neither trait hostility nor hostile interpretation bias were uniquely associated with motivation to quit, reasons for quitting, nicotine dependence, or problematic symptoms following past cessation attempts. However, hostility and hostile interpretation biases were uniquely associated with different reasons for smoking. Additionally, greater hostile interpretation bias (but not hostility) was uniquely associated with early relapse following past cessation attempts. The current findings add uniquely to the growing, but still relatively small, literature on hostility and smoking and implicate hostile interpretation bias as a potential treatment target in smoking cessation interventions.

Evolution of Indian land surface biases in the seasonal hindcasts from the Met Office Global Seasonal Forecasting System GloSea5

NASA Astrophysics Data System (ADS)

Chevuturi, Amulya; Turner, Andrew G.; Woolnoug, Steve J.; Martin, Gill

2017-04-01

In this study we investigate the development of biases over the Indian region in summer hindcasts of the UK Met Office coupled initialised global seasonal forecasting system, GloSea5-GC2. Previous work has demonstrated the rapid evolution of strong monsoon circulation biases over India from seasonal forecasts initialised in early May, together with coupled strong easterly wind biases on the equator. These mean state biases lead to strong precipitation errors during the monsoon over the subcontinent. We analyse a set of three springtime start dates for the 20-year hindcast period (1992-2011) and fifteen total ensemble members for each year. We use comparisons with variety of observations to assess the evolution of the mean state biases over the Indian land surface. All biases within the model develop rapidly, particularly surface heat and radiation flux biases. Strong biases are present within the model climatology from pre-monsoon (May) in the surface heat fluxes over India (higher sensible / lower latent heat fluxes) when compared to observed estimates. The early evolution of such biases prior to onset rains suggests possible problems with the land surface scheme or soil moisture errors. Further analysis of soil moisture over the Indian land surface shows a dry bias present from the beginning of the hindcasts during the pre-monsoon. This lasts until the after the monsoon develops (July) after which there is a wet bias over the region. Soil moisture used for initialization of the model also shows a dry bias when compared against the observed estimates, which may lead to the same in the model. The early dry bias in the model may reduce local moisture availability through surface evaporation and thus may possibly limit precipitation recycling. On this premise, we identify and test the sensitivity of the monsoon in the model against higher soil moisture forcing. We run sensitivity experiments initiated using gridpoint-wise annual soil moisture maxima over the Indian

Design of ProjectRun21: a 14-week prospective cohort study of the influence of running experience and running pace on running-related injury in half-marathoners.

PubMed

Damsted, Camma; Parner, Erik Thorlund; Sørensen, Henrik; Malisoux, Laurent; Nielsen, Rasmus Oestergaard

2017-11-06

Participation in half-marathon has been steeply increasing during the past decade. In line, a vast number of half-marathon running schedules has surfaced. Unfortunately, the injury incidence proportion for half-marathoners has been found to exceed 30% during 1-year follow-up. The majority of running-related injuries are suggested to develop as overuse injuries, which leads to injury if the cumulative training load over one or more training sessions exceeds the runners' load capacity for adaptive tissue repair. Owing to an increase of load capacity along with adaptive running training, the runners' running experience and pace abilities can be used as estimates for load capacity. Since no evidence-based knowledge exist of how to plan appropriate half-marathon running schedules considering the level of running experience and running pace, the aim of ProjectRun21 is to investigate the association between running experience or running pace and the risk of running-related injury. Healthy runners using Global Positioning System (GPS) watch between 18 and 65 years will be invited to participate in this 14-week prospective cohort study. Runners will be allowed to self-select one of three half-marathon running schedules developed for the study. Running data will be collected objectively by GPS. Injury will be based on the consensus-based time loss definition by Yamato et al.: "Running-related (training or competition) musculoskeletal pain in the lower limbs that causes a restriction on or stoppage of running (distance, speed, duration, or training) for at least 7 days or 3 consecutive scheduled training sessions, or that requires the runner to consult a physician or other health professional". Running experience and running pace will be included as primary exposures, while the exposure to running is pre-fixed in the running schedules and thereby conditioned by design. Time-to-event models will be used for analytical purposes. ProjectRun21 will examine if particular

A Diffusion Approximation Based on Renewal Processes with Applications to Strongly Biased Run-Tumble Motion.

PubMed

Thygesen, Uffe Høgsbro

2016-03-01

We consider organisms which use a renewal strategy such as run-tumble when moving in space, for example to perform chemotaxis in chemical gradients. We derive a diffusion approximation for the motion, applying a central limit theorem due to Anscombe for renewal-reward processes; this theorem has not previously been applied in this context. Our results extend previous work, which has established the mean drift but not the diffusivity. For a classical model of tumble rates applied to chemotaxis, we find that the resulting chemotactic drift saturates to the swimming velocity of the organism when the chemical gradients grow increasingly steep. The dispersal becomes anisotropic in steep gradients, with larger dispersal across the gradient than along the gradient. In contrast to one-dimensional settings, strong bias increases dispersal. We next include Brownian rotation in the model and find that, in limit of high chemotactic sensitivity, the chemotactic drift is 64% of the swimming velocity, independent of the magnitude of the Brownian rotation. We finally derive characteristic timescales of the motion that can be used to assess whether the diffusion limit is justified in a given situation. The proposed technique for obtaining diffusion approximations is conceptually and computationally simple, and applicable also when statistics of the motion is obtained empirically or through Monte Carlo simulation of the motion.

Eye coding mechanisms in early human face event-related potentials.

PubMed

Rousselet, Guillaume A; Ince, Robin A A; van Rijsbergen, Nicola J; Schyns, Philippe G

2014-11-10

In humans, the N170 event-related potential (ERP) is an integrated measure of cortical activity that varies in amplitude and latency across trials. Researchers often conjecture that N170 variations reflect cortical mechanisms of stimulus coding for recognition. Here, to settle the conjecture and understand cortical information processing mechanisms, we unraveled the coding function of N170 latency and amplitude variations in possibly the simplest socially important natural visual task: face detection. On each experimental trial, 16 observers saw face and noise pictures sparsely sampled with small Gaussian apertures. Reverse-correlation methods coupled with information theory revealed that the presence of the eye specifically covaries with behavioral and neural measurements: the left eye strongly modulates reaction times and lateral electrodes represent mainly the presence of the contralateral eye during the rising part of the N170, with maximum sensitivity before the N170 peak. Furthermore, single-trial N170 latencies code more about the presence of the contralateral eye than N170 amplitudes and early latencies are associated with faster reaction times. The absence of these effects in control images that did not contain a face refutes alternative accounts based on retinal biases or allocation of attention to the eye location on the face. We conclude that the rising part of the N170, roughly 120-170 ms post-stimulus, is a critical time-window in human face processing mechanisms, reflecting predominantly, in a face detection task, the encoding of a single feature: the contralateral eye. © 2014 ARVO.

Running Improves Pattern Separation during Novel Object Recognition.

PubMed

Bolz, Leoni; Heigele, Stefanie; Bischofberger, Josef

2015-10-09

Running increases adult neurogenesis and improves pattern separation in various memory tasks including context fear conditioning or touch-screen based spatial learning. However, it is unknown whether pattern separation is improved in spontaneous behavior, not emotionally biased by positive or negative reinforcement. Here we investigated the effect of voluntary running on pattern separation during novel object recognition in mice using relatively similar or substantially different objects.We show that running increases hippocampal neurogenesis but does not affect object recognition memory with 1.5 h delay after sample phase. By contrast, at 24 h delay, running significantly improves recognition memory for similar objects, whereas highly different objects can be distinguished by both, running and sedentary mice. These data show that physical exercise improves pattern separation, independent of negative or positive reinforcement. In sedentary mice there is a pronounced temporal gradient for remembering object details. In running mice, however, increased neurogenesis improves hippocampal coding and temporally preserves distinction of novel objects from familiar ones.

The Importance of First Impressions: Early Events in Mycobacterium tuberculosis Infection Influence Outcome.

PubMed

Cadena, Anthony M; Flynn, JoAnne L; Fortune, Sarah M

2016-04-05

Tuberculosis remains a major health threat in much of the world. New vaccines against Mycobacterium tuberculosis are essential for preventing infection, disease, and transmission. However, the host immune responses that need to be induced by an effective vaccine remain unclear. Increasingly, it has become clear that early events in infection are of major importance in the eventual outcome of the infection. Studying such events in humans is challenging, as they occur within the lung and thoracic lymph nodes, and any clinical signs of early infection are relatively nonspecific. Nonetheless, clinical studies and animal models of tuberculosis have provided new insights into the local events that occur in the first few weeks of tuberculosis. Development of an effective vaccine requires a clear understanding of the successful (and detrimental) early host responses against M. tuberculosis, with the goal to improve upon natural immune responses and prevent infection or disease. Copyright © 2016 Cadena et al.

Meta-assessment of bias in science

PubMed Central

Fanelli, Daniele; Costas, Rodrigo; Ioannidis, John P. A.

2017-01-01

Numerous biases are believed to affect the scientific literature, but their actual prevalence across disciplines is unknown. To gain a comprehensive picture of the potential imprint of bias in science, we probed for the most commonly postulated bias-related patterns and risk factors, in a large random sample of meta-analyses taken from all disciplines. The magnitude of these biases varied widely across fields and was overall relatively small. However, we consistently observed a significant risk of small, early, and highly cited studies to overestimate effects and of studies not published in peer-reviewed journals to underestimate them. We also found at least partial confirmation of previous evidence suggesting that US studies and early studies might report more extreme effects, although these effects were smaller and more heterogeneously distributed across meta-analyses and disciplines. Authors publishing at high rates and receiving many citations were, overall, not at greater risk of bias. However, effect sizes were likely to be overestimated by early-career researchers, those working in small or long-distance collaborations, and those responsible for scientific misconduct, supporting hypotheses that connect bias to situational factors, lack of mutual control, and individual integrity. Some of these patterns and risk factors might have modestly increased in intensity over time, particularly in the social sciences. Our findings suggest that, besides one being routinely cautious that published small, highly-cited, and earlier studies may yield inflated results, the feasibility and costs of interventions to attenuate biases in the literature might need to be discussed on a discipline-specific and topic-specific basis. PMID:28320937

Calcaneus length determines running economy: implications for endurance running performance in modern humans and Neandertals.

PubMed

Raichlen, David A; Armstrong, Hunter; Lieberman, Daniel E

2011-03-01

The endurance running (ER) hypothesis suggests that distance running played an important role in the evolution of the genus Homo. Most researchers have focused on ER performance in modern humans, or on reconstructing ER performance in Homo erectus, however, few studies have examined ER capabilities in other members of the genus Homo. Here, we examine skeletal correlates of ER performance in modern humans in order to evaluate the energetics of running in Neandertals and early Homo sapiens. Recent research suggests that running economy (the energy cost of running at a given speed) is strongly related to the length of the Achilles tendon moment arm. Shorter moment arms allow for greater storage and release of elastic strain energy, reducing energy costs. Here, we show that a skeletal correlate of Achilles tendon moment arm length, the length of the calcaneal tuber, does not correlate with walking economy, but correlates significantly with running economy and explains a high proportion of the variance (80%) in cost between individuals. Neandertals had relatively longer calcaneal tubers than modern humans, which would have increased their energy costs of running. Calcaneal tuber lengths in early H. sapiens do not significantly differ from those of extant modern humans, suggesting Neandertal ER economy was reduced relative to contemporaneous anatomically modern humans. Endurance running is generally thought to be beneficial for gaining access to meat in hot environments, where hominins could have used pursuit hunting to run prey taxa into hyperthermia. We hypothesize that ER performance may have been reduced in Neandertals because they lived in cold climates. Copyright © 2011 Elsevier Ltd. All rights reserved.

Biased towards food: Electrophysiological evidence for biased attention to food stimuli.

PubMed

Kumar, Sanjay; Higgs, Suzanne; Rutters, Femke; Humphreys, Glyn W

2016-12-01

We investigated the neural mechanisms involved in bias for food stimuli in our visual environment using event related lateralized (ERL) responses. The participants were presented with a cue (food or non-food item) to either identify or hold in working memory. Subsequently, they had to search for a target in a 2-item display where target and distractor stimuli were each flanked by a picture of a food or a non-food item. The behavioural data showed that performance was strongly affected by food cues, especially when food was held in WM compared to when the cues were merely identified. The temporal dynamics of electrophysiological measures of attention (the N1pc and N2pc) showed that the orienting of attention towards food stimuli was associated with two different mechanisms; an early stage of attentional suppression followed by a later stage of attentional orienting towards food stimuli. In contrast, non-food cues were associated only with the guidance of attention to or away from cued stimuli on valid and invalid trials. The results demonstrate that food items, perhaps due to their motivational significance modulate the early orienting of attention, including an initial suppressive response to food items. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Analysis of near-surface biases in ERA-Interim over the Canadian Prairies

NASA Astrophysics Data System (ADS)

Betts, Alan K.; Beljaars, Anton C. M.

2017-09-01

We quantify the biases in the diurnal cycle of temperature in ERA-Interim for both warm and cold season using hourly climate station data for four stations in Saskatchewan from 1979 to 2006. The warm season biases increase as opaque cloud cover decreases, and change substantially from April to October. The bias in mean temperature increases almost monotonically from small negative values in April to small positive values in the fall. Under clear skies, the bias in maximum temperature is of the order of -1°C in June and July, and -2°C in spring and fall; while the bias in minimum temperature increases almost monotonically from +1°C in spring to +2.5°C in October. The bias in the diurnal temperature range falls under clear skies from -2.5°C in spring to -5°C in fall. The cold season biases with surface snow have a different structure. The biases in maximum, mean and minimum temperature with a stable BL reach +1°C, +2.6°C and +3°C respectively in January under clear skies. The cold season bias in diurnal range increases from about -1.8°C in the fall to positive values in March. These diurnal biases in 2 m temperature and their seasonal trends are consistent with a high bias in both the diurnal and seasonal amplitude of the model ground heat flux, and a warm season daytime bias resulting from the model fixed leaf area index. Our results can be used as bias corrections in agricultural modeling that use these reanalysis data, and also as a framework for understanding model biases.

29 CFR 1206.1 - Run-off elections.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 4 2011-07-01 2011-07-01 false Run-off elections. 1206.1 Section 1206.1 Labor Regulations... LABOR ACT § 1206.1 Run-off elections. (a) If in an election among any craft or class no organization or individual receives a majority of the legal votes cast, or in the event of a tie vote, a second or run-off...

29 CFR 1206.1 - Run-off elections.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Run-off elections. 1206.1 Section 1206.1 Labor Regulations... LABOR ACT § 1206.1 Run-off elections. (a) If in an election among any craft or class no organization or individual receives a majority of the legal votes cast, or in the event of a tie vote, a second or run-off...

Early Triassic alternative ecological states driven by anoxia, hyperthermals, and erosional pulses following the end-Permian mass extinction

NASA Astrophysics Data System (ADS)

Pietsch, C.; Petsios, E.; Bottjer, D. J.

2015-12-01

The end-Permian mass extinction, 252 million years ago, was the most devastating loss of biodiversity in Earth's history. Massive volcanic eruptions of the Siberian Traps and the concurrent burning of coal, carbonate, and evaporite deposits emplaced greenhouse and toxic gasses. Hyperthermal events of the surface ocean, up to 40°C, led to reduced gradient-driven ocean circulation which yielded extensive equatorial oxygen minimum zones. Today, anthropogenic greenhouse gas production is outpacing carbon input modeled for the end-Permian mass extinction, which suggests that modern ecosystems may yet experience a severe biotic crisis. The Early Triassic records the 5 million year aftermath of the end-Permian mass extinction and is often perceived as an interval of delayed recovery. We combined a new, high resolution carbon isotope record, sedimentological analysis, and paleoecological collections from the Italian Werfen Formation to fully integrate paleoenvironmental change with the benthic ecological response. We find that the marine ecosystem experienced additional community restructuring events due to subsequent hyperthermal events and pulses of erosion. The benthic microfauna and macrofauna both contributed to disaster communities that initially rebounded in the earliest Triassic. 'Disaster fauna' including microbialites, microconchids, foraminifera, and "flat clams" took advantage of anoxic conditions in the first ~500,000 years, dominating the benthic fauna. Later, in the re-oxygenated water column, opportunistic disaster groups were supplanted by a more diverse, mollusc-dominated benthic fauna and a complex ichnofauna. An extreme temperature run-up beginning in the Late Dienerian led to an additional hyperthermal event in the Late-Smithian which co-occurred with increased humidity and terrestrial run-off. Massive siliciclastic deposits replaced carbonate deposition which corresponds to the infaunalization of the benthic fauna. The disaster taxa dominated

SLF Run & Walk

NASA Image and Video Library

2018-03-13

Kennedy Space Center Director Bob Cabana approaches the finish line at the KSC Walk Run on the Shuttle Landing Facility runway. The annual event, part of Kennedy’s Safety and Health Days, offers 10K, 5K and 2-mile options in the spirit of friendly competition.

SLF Run & Walk

NASA Image and Video Library

2018-03-13

A line of Kennedy Space Center employees and guests stretches down the Shuttle Landing Facility Runway during the KSC Walk Run. The annual event, part of Kennedy’s Safety and Health Days, offers 10K, 5K and 2-mile options in the spirit of friendly competition.

Deterministic photon bias in speckle imaging

NASA Technical Reports Server (NTRS)

Beletic, James W.

1989-01-01

A method for determining photo bias terms in speckle imaging is presented, and photon bias is shown to be a deterministic quantity that can be calculated without the use of the expectation operator. The quantities obtained are found to be identical to previous results. The present results have extended photon bias calculations to the important case of the bispectrum where photon events are assigned different weights, in which regime the bias is a frequency dependent complex quantity that must be calculated for each frame.

Challenges of Guarantee-Time Bias

PubMed Central

Giobbie-Hurder, Anita; Gelber, Richard D.; Regan, Meredith M.

2013-01-01

The potential for guarantee-time bias (GTB), also known as immortal time bias, exists whenever an analysis that is timed from enrollment or random assignment, such as disease-free or overall survival, is compared across groups defined by a classifying event occurring sometime during follow-up. The types of events associated with GTB are varied and may include the occurrence of objective disease response, onset of toxicity, or seroconversion. However, comparative analyses using these types of events as predictors are different from analyses using baseline characteristics that are specified completely before the occurrence of any outcome event. Recognizing the potential for GTB is not always straightforward, and it can be challenging to know when GTB is influencing the results of an analysis. This article defines GTB, provides examples of GTB from several published articles, and discusses three analytic techniques that can be used to remove the bias: conditional landmark analysis, extended Cox model, and inverse probability weighting. The strengths and limitations of each technique are presented. As an example, we explore the effect of bisphosphonate use on disease-free survival (DFS) using data from the BIG (Breast International Group) 1-98 randomized clinical trial. An analysis using a naive approach showed substantial benefit for patients who received bisphosphonate therapy. In contrast, analyses using the three methods known to remove GTB showed no statistical evidence of a reduction in risk of a DFS event with bisphosphonate therapy. PMID:23835712

A goal bias in action: The boundaries adults perceive in events align with sites of actor intent.

PubMed

Levine, Dani; Hirsh-Pasek, Kathy; Pace, Amy; Michnick Golinkoff, Roberta

2017-06-01

We live in a dynamic world comprised of continuous events. Remembering our past and predicting future events, however, requires that we segment these ongoing streams of information in a consistent manner. How is this segmentation achieved? This research examines whether the boundaries adults perceive in events, such as the Olympic figure skating routine used in these studies, align with the beginnings (sources) and endings (goals) of human goal-directed actions. Study 1 showed that a group of experts, given an explicit task with unlimited time to rewatch the event, identified the same subevents as one another, but with greater agreement as to the timing of goals than sources. In Study 2, experts, novices familiarized with the figure skating sequence, and unfamiliarized novices performed an online event segmentation task, marking boundaries as the video progressed in real time. The online boundaries of all groups corresponded with the sources and goals offered by Study 1's experts, with greater alignment of goals than sources. Additionally, expertise, but not mere perceptual familiarity, boosted the alignment of sources and goals. Finally, Study 3, which presented novices with the video played in reverse, indicated, unexpectedly, that even when spatiotemporal cues were disrupted, viewers' perceived event boundaries still aligned with their perception of the actors' intended sources and goals. This research extends the goal bias to event segmentation, and suggests that our spontaneous sensitivity toward goals may allow us to transform even relatively complex and unfamiliar event streams into structured and meaningful representations. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Quantifying the extent to which index event biases influence large genetic association studies.

PubMed

Yaghootkar, Hanieh; Bancks, Michael P; Jones, Sam E; McDaid, Aaron; Beaumont, Robin; Donnelly, Louise; Wood, Andrew R; Campbell, Archie; Tyrrell, Jessica; Hocking, Lynne J; Tuke, Marcus A; Ruth, Katherine S; Pearson, Ewan R; Murray, Anna; Freathy, Rachel M; Munroe, Patricia B; Hayward, Caroline; Palmer, Colin; Weedon, Michael N; Pankow, James S; Frayling, Timothy M; Kutalik, Zoltán

2017-03-01

As genetic association studies increase in size to 100 000s of individuals, subtle biases may influence conclusions. One possible bias is 'index event bias' (IEB) that appears due to the stratification by, or enrichment for, disease status when testing associations between genetic variants and a disease-associated trait. We aimed to test the extent to which IEB influences some known trait associations in a range of study designs and provide a statistical framework for assessing future associations. Analyzing data from 113 203 non-diabetic UK Biobank participants, we observed three (near TCF7L2, CDKN2AB and CDKAL1) overestimated (body mass index (BMI) decreasing) and one (near MTNR1B) underestimated (BMI increasing) associations among 11 type 2 diabetes risk alleles (at P  <  0.05). IEB became even stronger when we tested a type 2 diabetes genetic risk score composed of these 11 variants (-0.010 standard deviations BMI per allele, P  =  5 × 10- 4), which was confirmed in four additional independent studies. Similar results emerged when examining the effect of blood pressure increasing alleles on BMI in normotensive UK Biobank samples. Furthermore, we demonstrated that, under realistic scenarios, common disease alleles would become associated at P <  5 × 10- 8 with disease-related traits through IEB alone, if disease prevalence in the sample differs appreciably from the background population prevalence. For example, some hypertension and type 2 diabetes alleles will be associated with BMI in sample sizes of  >500 000 if the prevalence of those diseases differs by >10% from the background population. In conclusion, IEB may result in false positive or negative genetic associations in very large studies stratified or strongly enriched for/against disease cases. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Affective forecasting bias in preschool children.

PubMed

Gautam, Shalini; Bulley, Adam; von Hippel, William; Suddendorf, Thomas

2017-07-01

Adults are capable of predicting their emotional reactions to possible future events. Nevertheless, they systematically overestimate the intensity of their future emotional reactions relative to how they feel when these events actually occur. The developmental origin of this "intensity bias" has not yet been examined. Two studies were conducted to test the intensity bias in preschool children. In the first study, 5-year-olds (N=30) predicted how they would feel if they won or lost various games. Comparisons with subsequent self-reported feelings indicated that participants overestimated how sad they would feel to lose the games but did not overestimate their happiness from winning. The second study replicated this effect in another sample of 5-year-olds (n=34) and also found evidence of an intensity bias in 4-year-olds (n=30). These findings provide the first evidence of a negative intensity bias in affective forecasting among young children. Copyright © 2017 Elsevier Inc. All rights reserved.

Collaborative Project: Understanding Climate Model Biases in Tropical Atlantic and Their Impact on Simulations of Extreme Climate Events

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, Ping

Recent studies have revealed that among all the tropical oceans, the tropical Atlantic has experienced the most pronounced warming trend over the 20th century. Many extreme climate events affecting the U.S., such as hurricanes, severe precipitation and drought events, are influenced by conditions in the Gulf of Mexico and the Atlantic Ocean. It is therefore imperative to have accurate simulations of the climatic mean and variability in the Atlantic region to be able to make credible projections of future climate change affecting the U.S. and other countries adjoining the Atlantic Ocean. Unfortunately, almost all global climate models exhibit large biasesmore » in their simulations of tropical Atlantic climate. The atmospheric convection simulation errors in the Amazon region and the associated errors in the trade wind simulations are hypothesized to be a leading cause of the tropical Atlantic biases in climate models. As global climate models have resolutions that are too coarse to resolve some of the atmospheric and oceanic processes responsible for the model biases, we propose to use a high-resolution coupled regional climate model (CRCM) framework to address the tropical bias issue. We propose to combine the expertise in tropical coupled atmosphere-ocean modeling at Texas A&M University (TAMU) and the coupled land-atmosphere modeling expertise at Pacific Northwest National Laboratory (PNNL) to develop a comprehensive CRCM for the Atlantic sector within a general and flexible modeling framework. The atmospheric component of the CRCM will be the NCAR WRF model and the oceanic component will be the Rutgers/UCLA ROMS. For the land component, we will use CLM modified at PNNL to include more detailed representations of vegetation and soil hydrology processes. The combined TAMU-PNNL CRCM model will be used to simulate the Atlantic climate, and the associated land-atmosphere-ocean interactions at a horizontal resolution of 9 km or finer. A particular focus of the

Immortal time bias in pharmaco-epidemiology.

PubMed

Suissa, Samy

2008-02-15

Immortal time is a span of cohort follow-up during which, because of exposure definition, the outcome under study could not occur. Bias from immortal time was first identified in the 1970s in epidemiology in the context of cohort studies of the survival benefit of heart transplantation. It recently resurfaced in pharmaco-epidemiology, with several observational studies reporting that various medications can be extremely effective at reducing morbidity and mortality. These studies, while using different cohort designs, all involved some form of immortal time and the corresponding bias. In this paper, the author describes various cohort study designs leading to this bias, quantifies its magnitude under different survival distributions, and illustrates it by using data from a cohort of lung cancer patients. The author shows that for time-based, event-based, and exposure-based cohort definitions, the bias in the rate ratio resulting from misclassified or excluded immortal time increases proportionately to the duration of immortal time. The bias is more pronounced with a decreasing hazard function for the outcome event, as illustrated with the Weibull distribution compared with a constant hazard from the exponential distribution. In conclusion, observational studies of drug benefit in which computerized databases are used must be designed and analyzed properly to avoid immortal time bias.

Teaching Bank Runs with Classroom Experiments

ERIC Educational Resources Information Center

Balkenborg, Dieter; Kaplan, Todd; Miller, Timothy

2011-01-01

Once relegated to cinema or history lectures, bank runs have become a modern phenomenon that captures the interest of students. In this article, the authors explain a simple classroom experiment based on the Diamond-Dybvig model (1983) to demonstrate how a bank run--a seemingly irrational event--can occur rationally. They then present possible…

Early/fast VLF events produced by the quiescent heating of the lower ionosphere by thunderstorms

NASA Astrophysics Data System (ADS)

Kabirzadeh, R.; Marshall, R. A.; Inan, U. S.

2017-06-01

Large and easily distinguishable perturbations of the VLF transmitter signals due to interactions with thundercloud-driven ionospheric modifications have been observed and studied for about three decades. These events are called "early/fast VLF" or "early VLF" events due to their immediate detection (˜20 ms) after the causative lightning flash on the ground and the fast rise time of the perturbed signal. Despite many years of study, the physical mechanisms responsible for these perturbations are still under investigation. Modifications of the sustained heating level of the ionosphere due to a lightning flash has been previously proposed as the causative mechanism of early/fast VLF events. The perturbations predicted by this mechanism, however, have been much smaller than experimental observations of 0.2-1 dB or higher. In this study, by using an improved 3-D thundercloud electrostatic upward coupling model which uses a realistic geomagnetic field, we find that the sustained heating model can predict perturbations that are consistent with reported experimental observations. Modifications in the quiescent heating of the lower ionosphere by thundercloud fields by individual lightning flashes may thus account for some observations of early/fast VLF events.

9 CFR 147.51 - Authorized laboratory minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Authorized laboratory minimum requirements. 147.51 Section 147.51 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE.... The testing procedures at the laboratory must be run or overseen by a laboratory technician who has...

9 CFR 147.51 - Authorized laboratory minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Authorized laboratory minimum requirements. 147.51 Section 147.51 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE.... The testing procedures at the laboratory must be run or overseen by a laboratory technician who has...

9 CFR 147.51 - Authorized laboratory minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Authorized laboratory minimum requirements. 147.51 Section 147.51 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE.... The testing procedures at the laboratory must be run or overseen by a laboratory technician who has...

9 CFR 147.51 - Authorized laboratory minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Authorized laboratory minimum requirements. 147.51 Section 147.51 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE.... The testing procedures at the laboratory must be run or overseen by a laboratory technician who has...

9 CFR 147.51 - Authorized laboratory minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Authorized laboratory minimum requirements. 147.51 Section 147.51 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE.... The testing procedures at the laboratory must be run or overseen by a laboratory technician who has...

Obstacle course runs: review of acquired injuries and illnesses at a series of Canadian events (RACE).

PubMed

Hawley, Alana; Mercuri, Mathew; Hogg, Kerstin; Hanel, Erich

2017-03-01

The growing popularity of obstacle course runs (OCRs) has led to significant concerns regarding their safety. The influx of injuries and illnesses in rural areas where OCRs are often held can impose a large burden on emergency medical services (EMS) and local EDs. Literature concerning the safety of these events is minimal and mostly consists of media reports. We sought to characterise the injury and illness profile of OCRs and the level of medical care required. This study analysed OCR events occurring in eight locations across Canada from May to August 2015 (total 45 285 participants). Data were extracted from event medical charts of patients presenting to the onsite medical team, including injury or illness type, onsite treatment and disposition. There were 557 race participants treated at eight OCR events (1.2% of all participants). There were 609 medical complaints in total. Three quarters of injuries were musculoskeletal in nature. Eighty-nine per cent returned to the event with no need for further medical care. The majority of treatments were completed with first aid and basic medical equipment. Eleven patients (2% of patients) required transfer to hospital by EMS for presentations including fracture, dislocation, head injury, chest pain, fall from height, and abdominal pain. We found that 1.2% of race participants presented to onsite medical services. The majority of complaints were minor and musculoskeletal in nature. Only 2% of those treated were transferred to hospital through EMS. This is consistent with other types of mass gathering events. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Does the Size of the Effect of Adverse Events at High Ages on Daily-Life Physical Functioning Depend on the Economic Conditions Around Birth?

PubMed

Scholte, Robert; van den Berg, Gerard J; Lindeboom, Maarten; Deeg, Dorly J H

2017-01-01

This paper considers determinants of physical functional limitations in daily-life activities at high ages. Specifically, we quantify the extent to which the impact of adverse life events on this outcome is larger in case of exposure to adverse economic conditions early in life. Adverse life events include bereavement, severe illness in the family, and the onset of chronic diseases. We use a longitudinal data set of individuals born in the first decades of the 20th century. The business cycle around birth is used as an indicator of economic conditions early in life. We find that the extent to which functional limitations suffer from the onset of chronic diseases is larger if the individual was born in a recession. The long-run effect of economic conditions early in life on functional limitations at high ages runs primarily via this life event. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Anticipatory Guidance for Long-Distance Running in Young Athletes.

PubMed

Blankson, Kwabena L; Brenner, Joel S

2016-03-01

More young children are participating in endurance running events such as full and half marathons, and the safety of these events for children has been heavily debated. There is a paucity of evidence on either side of the debate. However, overuse injuries, stress fractures, as well as the potential for psychologic burnout are legitimate concerns. Parents who are seeking advice from pediatricians about child participation in these endurance events should be made aware of these risks. Young children may participate in endurance running events under close supervision from health professionals, coaches, and parents, with full medical evaluation before initiation of training, throughout training, as well as 6 to 12 months post-race. Special attention should be made to the psychologic well-being of the child, with the participation in running being child-driven, not parent- or coach-driven, and emphasis on enjoyment and fitness, not competition. Copyright 2016, SLACK Incorporated.

Bias Correction for Assimilation of Retrieved AIRS Profiles of Temperature and Humidity

NASA Technical Reports Server (NTRS)

Blakenship, Clay; Zavodsky, Bradley; Blackwell, William

2014-01-01

The Atmospheric Infrared Sounder (AIRS) is a hyperspectral radiometer aboard NASA's Aqua satellite designed to measure atmospheric profiles of temperature and humidity. AIRS retrievals are assimilated into the Weather Research and Forecasting (WRF) model over the North Pacific for some cases involving "atmospheric rivers". These events bring a large flux of water vapor to the west coast of North America and often lead to extreme precipitation in the coastal mountain ranges. An advantage of assimilating retrievals rather than radiances is that information in partly cloudy fields of view can be used. Two different Level 2 AIRS retrieval products are compared: the Version 6 AIRS Science Team standard retrievals and a neural net retrieval from MIT. Before assimilation, a bias correction is applied to adjust each layer of retrieved temperature and humidity so the layer mean values agree with a short-term model climatology. WRF runs assimilating each of the products are compared against each other and against a control run with no assimilation. Forecasts are against ERA reanalyses.

The reliability of eyetracking to assess attentional bias to threatening words in healthy individuals.

PubMed

Skinner, Ian W; Hübscher, Markus; Moseley, G Lorimer; Lee, Hopin; Wand, Benedict M; Traeger, Adrian C; Gustin, Sylvia M; McAuley, James H

2017-08-15

Eyetracking is commonly used to investigate attentional bias. Although some studies have investigated the internal consistency of eyetracking, data are scarce on the test-retest reliability and agreement of eyetracking to investigate attentional bias. This study reports the test-retest reliability, measurement error, and internal consistency of 12 commonly used outcome measures thought to reflect the different components of attentional bias: overall attention, early attention, and late attention. Healthy participants completed a preferential-looking eyetracking task that involved the presentation of threatening (sensory words, general threat words, and affective words) and nonthreatening words. We used intraclass correlation coefficients (ICCs) to measure test-retest reliability (ICC > .70 indicates adequate reliability). The ICCs(2, 1) ranged from -.31 to .71. Reliability varied according to the outcome measure and threat word category. Sensory words had a lower mean ICC (.08) than either affective words (.32) or general threat words (.29). A longer exposure time was associated with higher test-retest reliability. All of the outcome measures, except second-run dwell time, demonstrated low measurement error (<6%). Most of the outcome measures reported high internal consistency (α > .93). Recommendations are discussed for improving the reliability of eyetracking tasks in future research.

A New Event Builder for CMS Run II

NASA Astrophysics Data System (ADS)

Albertsson, K.; Andre, J.-M.; Andronidis, A.; Behrens, U.; Branson, J.; Chaze, O.; Cittolin, S.; Darlea, G.-L.; Deldicque, C.; Dobson, M.; Dupont, A.; Erhan, S.; Gigi, D.; Glege, F.; Gomez-Ceballos, G.; Hegeman, J.; Holzner, A.; Jimenez-Estupiñán, R.; Masetti, L.; Meijers, F.; Meschi, E.; Mommsen, R. K.; Morovic, S.; Nunez-Barranco-Fernandez, C.; O'Dell, V.; Orsini, L.; Paus, C.; Petrucci, A.; Pieri, M.; Racz, A.; Roberts, P.; Sakulin, H.; Schwick, C.; Stieger, B.; Sumorok, K.; Veverka, J.; Zaza, S.; Zejdl, P.

2015-12-01

The data acquisition system (DAQ) of the CMS experiment at the CERN Large Hadron Collider (LHC) assembles events at a rate of 100 kHz, transporting event data at an aggregate throughput of 100GB/s to the high-level trigger (HLT) farm. The DAQ system has been redesigned during the LHC shutdown in 2013/14. The new DAQ architecture is based on state-of-the-art network technologies for the event building. For the data concentration, 10/40 Gbps Ethernet technologies are used together with a reduced TCP/IP protocol implemented in FPGA for a reliable transport between custom electronics and commercial computing hardware. A 56 Gbps Infiniband FDR CLOS network has been chosen for the event builder. This paper discusses the software design, protocols, and optimizations for exploiting the hardware capabilities. We present performance measurements from small-scale prototypes and from the full-scale production system.

Persistence of carbon release events through the peak of early Eocene global warmth

NASA Astrophysics Data System (ADS)

Kirtland Turner, Sandra; Sexton, Philip F.; Charles, Christopher D.; Norris, Richard D.

2014-10-01

The Early Eocene Climatic Optimum (53-50 million years ago) was preceded by approximately six million years of progressive global warming. This warming was punctuated by a series of rapid hyperthermal warming events triggered by the release of greenhouse gases. Over these six million years, the carbon isotope record suggests that the events became more frequent but smaller in magnitude. This pattern has been suggested to reflect a thermodynamic threshold for carbon release that was more easily crossed as global temperature rose, combined with a decrease in the size of carbon reservoirs during extremely warm conditions. Here we present a continuous, 4.25-million-year-long record of the stable isotope composition of carbonate sediments from the equatorial Atlantic, spanning the peak of early Eocene global warmth. A composite of this and pre-existing records shows that the carbon isotope excursions that identify the hyperthermals exhibit continuity in magnitude and frequency throughout the approximately 10-million-year period covering the onset, peak and termination of the Early Eocene Climate Optimum. We suggest that the carbon cycle processes behind these events, excluding the largest event, the Palaeocene-Eocene Thermal Maximum (about 56 million years ago), were not exceptional. Instead, we argue that the hyperthermals may reflect orbital forcing of the carbon cycle analogous to the mechanisms proposed to operate in the cooler Oligocene and Miocene.

A new event builder for CMS Run II

DOE PAGES

Albertsson, K.; Andre, J-M; Andronidis, A.; ...

2015-12-23

The data acquisition system (DAQ) of the CMS experiment at the CERN Large Hadron Collider (LHC) assembles events at a rate of 100 kHz, transporting event data at an aggregate throughput of 100 GB/s to the high-level trigger (HLT) farm. The DAQ system has been redesigned during the LHC shutdown in 2013/14. The new DAQ architecture is based on state-of-the-art network technologies for the event building. For the data concentration, 10/40 Gbps Ethernet technologies are used together with a reduced TCP/IP protocol implemented in FPGA for a reliable transport between custom electronics and commercial computing hardware. A 56 Gbps Innibandmore » FDR CLOS network has been chosen for the event builder. This paper discusses the software design, protocols, and optimizations for exploiting the hardware capabilities. In conclusion, ee present performance measurements from small-scale prototypes and from the full-scale production system.« less

The effects of climatic fluctuations and extreme events on running water ecosystems

PubMed Central

Woodward, Guy; Bonada, Núria; Brown, Lee E.; Death, Russell G.; Durance, Isabelle; Gray, Clare; Hladyz, Sally; Ledger, Mark E.; Milner, Alexander M.; Ormerod, Steve J.; Thompson, Ross M.

2016-01-01

Most research on the effects of environmental change in freshwaters has focused on incremental changes in average conditions, rather than fluctuations or extreme events such as heatwaves, cold snaps, droughts, floods or wildfires, which may have even more profound consequences. Such events are commonly predicted to increase in frequency, intensity and duration with global climate change, with many systems being exposed to conditions with no recent historical precedent. We propose a mechanistic framework for predicting potential impacts of environmental fluctuations on running-water ecosystems by scaling up effects of fluctuations from individuals to entire ecosystems. This framework requires integration of four key components: effects of the environment on individual metabolism, metabolic and biomechanical constraints on fluctuating species interactions, assembly dynamics of local food webs, and mapping the dynamics of the meta-community onto ecosystem function. We illustrate the framework by developing a mathematical model of environmental fluctuations on dynamically assembling food webs. We highlight (currently limited) empirical evidence for emerging insights and theoretical predictions. For example, widely supported predictions about the effects of environmental fluctuations are: high vulnerability of species with high per capita metabolic demands such as large-bodied ones at the top of food webs; simplification of food web network structure and impaired energetic transfer efficiency; and reduced resilience and top-down relative to bottom-up regulation of food web and ecosystem processes. We conclude by identifying key questions and challenges that need to be addressed to develop more accurate and predictive bio-assessments of the effects of fluctuations, and implications of fluctuations for management practices in an increasingly uncertain world. PMID:27114576

Stabilization of the wheel running phenotype in mice.

PubMed

Bowen, Robert S; Cates, Brittany E; Combs, Eric B; Dillard, Bryce M; Epting, Jessica T; Foster, Brittany R; Patterson, Shawnee V; Spivey, Thomas P

2016-03-01

Increased physical activity is well known to improve health and wellness by modifying the risks for many chronic diseases. Rodent wheel running behavior is a beneficial surrogate model to evaluate the biology of daily physical activity in humans. Upon initial exposure to a running wheel, individual mice differentially respond to the experience, which confounds the normal activity patterns exhibited in this otherwise repeatable phenotype. To promote phenotypic stability, a minimum seven-day (or greater) acclimation period is utilized. Although phenotypic stabilization is achieved during this 7-day period, data to support acclimation periods of this length are not currently available in the literature. The purpose of this project is to evaluate the wheel running response in C57BL/6j mice immediately following exposure to a running wheel. Twenty-eight male and thirty female C57BL/6j mice (Jackson Laboratory, Bar Harbor, ME) were acquired at eight weeks of age and were housed individually with free access to running wheels. Wheel running distance (km), duration (min), and speed (m∙min(-1)) were measured daily for fourteen days following initial housing. One-way ANOVAs were used to evaluate day-to-day differences in each wheel running character. Limits of agreement and mean difference statistics were calculated between days 1-13 (acclimating) and day 14 (acclimated) to assess day-to-day agreement between each parameter. Wheel running distance (males: F=5.653, p=2.14 × 10(-9); females: F=8.217, p=1.20 × 10(-14)), duration (males: F=2.613, p=0.001; females: F=4.529, p=3.28 × 10(-7)), and speed (males: F=7.803, p=1.22 × 10(-13); females: F=13.140, p=2.00 × 10(-16)) exhibited day-to-day differences. Tukey's HSD post-hoc testing indicated differences between early (males: days 1-3; females: days 1-6) and later (males: days >3; females: days >6) wheel running periods in distance and speed. Duration only exhibited an anomalous difference between wheel running on day 13

Ophthalmic Vascular Events after Primary Unilateral Intra-arterial Chemotherapy for Retinoblastoma in Early and Recent Eras.

PubMed

Dalvin, Lauren A; Ancona-Lezama, David; Lucio-Alvarez, J Antonio; Masoomian, Babak; Jabbour, Pascal; Shields, Carol L

2018-06-16

To assess risk factors for ophthalmic vascular events after intra-arterial chemotherapy (IAC) for retinoblastoma. Retrospective cohort study. Patients who received unilateral IAC as primary treatment for retinoblastoma from January 1, 2009, to November 30, 2017, at a single center. Records were reviewed for patient demographics, tumor features, IAC parameters, and treatment-related vascular events in the early IAC era (2009-2011) compared with the recent era (2012-2017) using the t test and Fisher exact test. Change in event rates over time was assessed using Poisson regression analysis, with Spearman's rho used to test correlation. Rate of IAC-induced ophthalmic vascular events. There were 243 chemotherapy infusions in 76 eyes of 76 patients, divided into early (22 eyes, 57 infusions) and recent (54 eyes, 186 infusions) eras. Intra-arterial chemotherapy consisted of melphalan (243 infusions), topotecan (124 infusions), and carboplatin (9 infusions). A comparison (early vs. recent era) revealed fewer mean number of infusions (2.6 vs. 3.4, P = 0.02) with similar mean patient age and presenting tumor features. Event rates decreased over time (P < 0.01), with fewer ophthalmic vascular events (early era vs. recent era) in the recent era (59% vs. 9% per eye, 23% vs. 3% per infusion, P < 0.01), including peripheral retinal nonperfusion (5% vs. 2% per eye, P = 0.50), vitreous hemorrhage (9% vs. 2%, P = 0.20), subretinal hemorrhage (0% vs. 2%, P = 0.99), branch retinal vein occlusion (5% vs. 0%, P = 0.29), choroidal ischemia (14% vs. 4%, P = 0.14), and ophthalmic artery spasm/occlusion (27% vs. 0%, P < 0.01). Events did not correlate to patient age (P = 0.75), tumor diameter (P = 0.32), tumor thickness (P = 0.59), or cumulative dosage of melphalan (P = 0.13) or topotecan (P = 0.59). There were no IAC-induced vascular events in 72 infusions of 21 consecutively treated eyes in 2016 to 2017. Ophthalmic vascular events after IAC have decreased from the early era

Not all past events are equal: biased attention and emerging heuristics in children's past-to-future forecasting.

PubMed

Lagattuta, Kristin Hansen; Sayfan, Liat

2013-01-01

Four- to 10-year-olds and adults (N = 265) responded to eight scenarios presented on an eye tracker. Each trial involved a character who encounters a perpetrator who had previously enacted positive (P), negative (N), or both types of actions toward him or her in varying sequences (NN, PP, PN, and NP). Participants predicted the character's thoughts about the likelihood of future events, emotion type and intensity, and decision to approach or avoid. All ages made more positive forecasts for PP > NP > PN > NN trials, with differentiation by past experience widening with age. Age-related increases in weighting the most recent past event also appeared in eye gaze. Individual differences in biased visual attention correlated with verbal judgments. Findings contribute to research on risk assessment, person perception, and heuristics in judgment and decision making. © 2013 The Authors. Child Development © 2013 Society for Research in Child Development, Inc.

40 CFR 86.884-12 - Test run.

Code of Federal Regulations, 2010 CFR

2010-07-01

... zero and span settings of the smokemeter. (If a recorder is used, a chart speed of approximately one... collection, it shall be run at a minimum chart speed of one inch per minute during the idle mode and... zero and full scale response may be rechecked and reset during the idle mode of each test sequence. (v...

Single- and Dual-Process Models of Biased Contingency Detection

PubMed Central

2016-01-01

Abstract. Decades of research in causal and contingency learning show that people’s estimations of the degree of contingency between two events are easily biased by the relative probabilities of those two events. If two events co-occur frequently, then people tend to overestimate the strength of the contingency between them. Traditionally, these biases have been explained in terms of relatively simple single-process models of learning and reasoning. However, more recently some authors have found that these biases do not appear in all dependent variables and have proposed dual-process models to explain these dissociations between variables. In the present paper we review the evidence for dissociations supporting dual-process models and we point out important shortcomings of this literature. Some dissociations seem to be difficult to replicate or poorly generalizable and others can be attributed to methodological artifacts. Overall, we conclude that support for dual-process models of biased contingency detection is scarce and inconclusive. PMID:27025532

Single- and Dual-Process Models of Biased Contingency Detection.

PubMed

Vadillo, Miguel A; Blanco, Fernando; Yarritu, Ion; Matute, Helena

2016-01-01

Decades of research in causal and contingency learning show that people's estimations of the degree of contingency between two events are easily biased by the relative probabilities of those two events. If two events co-occur frequently, then people tend to overestimate the strength of the contingency between them. Traditionally, these biases have been explained in terms of relatively simple single-process models of learning and reasoning. However, more recently some authors have found that these biases do not appear in all dependent variables and have proposed dual-process models to explain these dissociations between variables. In the present paper we review the evidence for dissociations supporting dual-process models and we point out important shortcomings of this literature. Some dissociations seem to be difficult to replicate or poorly generalizable and others can be attributed to methodological artifacts. Overall, we conclude that support for dual-process models of biased contingency detection is scarce and inconclusive.

Biasing genome-editing events toward precise length deletions with an RNA-guided TevCas9 dual nuclease.

PubMed

Wolfs, Jason M; Hamilton, Thomas A; Lant, Jeremy T; Laforet, Marcon; Zhang, Jenny; Salemi, Louisa M; Gloor, Gregory B; Schild-Poulter, Caroline; Edgell, David R

2016-12-27

The CRISPR/Cas9 nuclease is commonly used to make gene knockouts. The blunt DNA ends generated by cleavage can be efficiently ligated by the classical nonhomologous end-joining repair pathway (c-NHEJ), regenerating the target site. This repair creates a cycle of cleavage, ligation, and target site regeneration that persists until sufficient modification of the DNA break by alternative NHEJ prevents further Cas9 cutting, generating a heterogeneous population of insertions and deletions typical of gene knockouts. Here, we develop a strategy to escape this cycle and bias events toward defined length deletions by creating an RNA-guided dual active site nuclease that generates two noncompatible DNA breaks at a target site, effectively deleting the majority of the target site such that it cannot be regenerated. The TevCas9 nuclease, a fusion of the I-TevI nuclease domain to Cas9, functions robustly in HEK293 cells and generates 33- to 36-bp deletions at frequencies up to 40%. Deep sequencing revealed minimal processing of TevCas9 products, consistent with protection of the DNA ends from exonucleolytic degradation and repair by the c-NHEJ pathway. Directed evolution experiments identified I-TevI variants with broadened targeting range, making TevCas9 an easy-to-use reagent. Our results highlight how the sequence-tolerant cleavage properties of the I-TevI homing endonuclease can be harnessed to enhance Cas9 applications, circumventing the cleavage and ligation cycle and biasing genome-editing events toward defined length deletions.

Run-up Variability due to Source Effects

NASA Astrophysics Data System (ADS)

Del Giudice, Tania; Zolezzi, Francesca; Traverso, Chiara; Valfrè, Giulio; Poggi, Pamela; Parker, Eric J.

2010-05-01

This paper investigates the variability of tsunami run-up at a specific location due to uncertainty in earthquake source parameters. It is important to quantify this 'inter-event' variability for probabilistic assessments of tsunami hazard. In principal, this aspect of variability could be studied by comparing field observations at a single location from a number of tsunamigenic events caused by the same source. As such an extensive dataset does not exist, we decided to study the inter-event variability through numerical modelling. We attempt to answer the question 'What is the potential variability of tsunami wave run-up at a specific site, for a given magnitude earthquake occurring at a known location'. The uncertainty is expected to arise from the lack of knowledge regarding the specific details of the fault rupture 'source' parameters. The following steps were followed: the statistical distributions of the main earthquake source parameters affecting the tsunami height were established by studying fault plane solutions of known earthquakes; a case study based on a possible tsunami impact on Egypt coast has been set up and simulated, varying the geometrical parameters of the source; simulation results have been analyzed deriving relationships between run-up height and source parameters; using the derived relationships a Monte Carlo simulation has been performed in order to create the necessary dataset to investigate the inter-event variability of the run-up height along the coast; the inter-event variability of the run-up height along the coast has been investigated. Given the distribution of source parameters and their variability, we studied how this variability propagates to the run-up height, using the Cornell 'Multi-grid coupled Tsunami Model' (COMCOT). The case study was based on the large thrust faulting offshore the south-western Greek coast, thought to have been responsible for the infamous 1303 tsunami. Numerical modelling of the event was used to

Temperament differentially influences early information processing in men and women: Preliminary electrophysiological evidence of attentional biases in healthy individuals.

PubMed

Pintzinger, Nina M; Pfabigan, Daniela M; Pfau, Lorenz; Kryspin-Exner, Ilse; Lamm, Claus

2017-01-01

Preferential processing of threat-related information is a robust finding in anxiety disorders. The observation that attentional biases are also present in healthy individuals suggests factors other than clinical symptoms to play a role. Using a dot-probe paradigm while event-related potentials were recorded in 59 healthy adults, we investigated whether temperament and gender, both related to individual variation in anxiety levels, influence attentional processing. All participants showed protective attentional biases in terms of enhanced attention engagement with positive information, indexed by larger N1 amplitudes in positive compared to negative conditions. Taking gender differences into account, we observed that women showed enhanced attention engagement with negative compared to neutral information, indicated by larger P2 amplitudes in congruent than in incongruent negative conditions. Attentional processing was influenced by the temperament traits negative affect and effortful control. Our results emphasize that gender and temperament modulate attentional biases in healthy adults. Copyright © 2016 Elsevier B.V. All rights reserved.

SLF Run & Walk

NASA Image and Video Library

2018-03-13

Kennedy Space Center Director Bob Cabana, center, is joined by a large group of center employees and guests as they participate in the KSC Walk Run on the Shuttle Landing Facility runway. The annual event, part of Kennedy’s Safety and Health Days, offers 10K, 5K and 2-mile options in the spirit of friendly competition.

A Longitudinal Study of Early Adolescent Precursors to Running Away

ERIC Educational Resources Information Center

Tyler, Kimberly A.; Bersani, Bianca E.

2008-01-01

Although previous research has examined correlates of running away among samples of currently homeless and runaway adolescents, little is known about what factors will predict the likelihood that a housed adolescent with no prior history of running away will leave home. As such, the current study uses the National Longitudinal Survey of Youth to…

The role of personal biases in the explanation of confabulation.

PubMed

Metcalf, Kasey; Langdon, Robyn; Coltheart, Max

2010-01-01

Previous research has demonstrated that motivational forces play an important role in determining the content of confabulation. In particular the content of confabulation has been shown to contain a positive emotional bias. This study investigated the role of personal biases in the confabulations of six patients with diverse aetiologies. Confabulations were elicited with a series of structured interviews. We then compared the patients' confabulations to their actual situations. Further analyses compared confabulations about current (i.e., the postmorbid period) and past (i.e., premorbid events and general life circumstances) events. Group analysis confirmed a general bias to recall events that were more positive than the reality. However, examination of individual cases revealed that positive biases were not universal. Confabulations about current circumstances showed the positive bias, whereas an emotional bias was not evident in past confabulations. We conclude that motivational forces play a role in determining the content of confabulations but conceive of this role primarily in terms of a need to maintain a consistent self-concept (whether positive or negative) overlaid upon the ease with which an individual can retrieve familiar premorbid daily activities and routines.

Inter-annual Variability of Temperature and Extreme Heat Events during the Nairobi Warm Season

NASA Astrophysics Data System (ADS)

Scott, A.; Misiani, H. O.; Zaitchik, B. F.; Ouma, G. O.; Anyah, R. O.; Jordan, A.

2016-12-01

Extreme heat events significantly stress all organisms in the ecosystem, and are likely to be amplified in peri-urban and urban areas. Understanding the variability and drivers behind these events is key to generating early warnings, yet in Equatorial East Africa, this information is currently unavailable. This study uses daily maximum and minimum temperature records from weather stations within Nairobi and its surroundings to characterize variability in daily minimum temperatures and the number of extreme heat events. ERA-Interim reanalysis is applied to assess the drivers of these events at event and seasonal time scales. At seasonal time scales, high temperatures in Nairobi are a function of large scale climate variability associated with the Atlantic Multi-decadal Oscillation (AMO) and Global Mean Sea Surface Temperature (GMSST). Extreme heat events, however, are more strongly associated with the El Nino Southern Oscillation (ENSO). For instance, the persistence of AMO and ENSO, in particular, provide a basis for seasonal prediction of extreme heat events/days in Nairobi. It is also apparent that the temporal signal from extreme heat events in tropics differs from classic heat wave definitions developed in the mid-latitudes, which suggests that a new approach for defining these events is necessary for tropical regions.

Immune to Situation: The Self-Serving Bias in Unambiguous Contexts

PubMed Central

Wang, Xiaoyan; Zheng, Li; Li, Lin; Zheng, Yijie; Sun, Peng; Zhou, Fanzhi A.; Guo, Xiuyan

2017-01-01

Traditionally, the self-serving bias has been investigated in ambiguous contexts in which participants work on tasks that measure novel abilities before making attributions without clear criteria for success or failure feedback. Prior studies have confirmed that the self-serving bias is pervasive in the general population, yet it varies significantly across situations involving ambiguous contexts. The present study features an unambiguous context encompassing interpersonal events that involved implicit causality (with the “self” as an actor or recipient), the inherent logic of which indicated attribution criteria. The aim of this study was to explore whether there is a self-serving bias in unambiguous contexts and to examine whether it is as sensitive to situation as it has been shown to be in ambiguous contexts. The results showed that, in an unambiguous context, participants exhibited self-serving bias in relation to attribution associated with negative interpersonal events. Additionally, the self-serving bias was greater in the actor condition relative to the recipient condition (Study 1), and this effect was not affected by the level of self-awareness, which was manipulated by the use or otherwise of a camera during the experiment (Study 2). Our findings provide evidence for the existence of the self-serving bias in unambiguous contexts. Moreover, the self-serving bias was shown to be immune to situation in unambiguous contexts, but it did depend on factors associated with the events per se, such as the actor versus recipient role that the self played in interpersonal events. PMID:28588532

Masking in reports of "most serious" events: bias in estimators of sports injury incidence in Canadian children.

PubMed

Gupta, A; Davidson, C M; McIsaac, M A

2016-08-01

Surveys that collect information on injuries often focus on the single "most serious" event to help limit recall error and reduce survey length. However, this can mask less serious injuries and result in biased incidence estimates for specific injury subcategories. Data from the 2002 Health Behaviour in School-aged Children (HBSC) survey and from the Canadian Hospitals Injury Reporting and Prevention Program (CHIRPP) were used to compare estimates of sports injury incidence in Canadian children. HBSC data indicate that 6.7% of children report sustaining a sports injury that required an emergency department (ED) visit. However, details were only collected on a child's "most serious" injury, so children who had multiple injuries requiring an ED visit may have had sports injuries that went unreported. The rate of 6.7% can be seen to be an underestimate by as much as 4.3%. Corresponding CHIRPP surveillance data indicate an incidence of 9.9%. Potential masking bias is also highlighted in our analysis of injuries attended by other health care providers. The "one most serious injury" line of questioning induces potentially substantial masking bias in the estimation of sports injury incidence, which limits researchers' ability to quantify the burden of sports injury. Longer survey recall periods naturally lead to greater masking. The design of future surveys should take these issues into account. In order to accurately inform policy decisions and the direction of future research, researchers must be aware of these limitations.

Describing Perceived Racial Bias Among Youth With Sickle Cell Disease.

PubMed

Wakefield, Emily O; Pantaleao, Ashley; Popp, Jill M; Dale, Lourdes P; Santanelli, James P; Litt, Mark D; Zempsky, William T

2018-03-17

Sickle cell disease (SCD) predominately affects Black Americans. This is the first study of its kind to describe the racial bias experiences of youth with SCD and their reactions to these experiences. Participants were 20 youth with SCD (ages 13-21 years) who were asked to describe any racial bias events they experienced, as recorded on the Perception of Racism in Children and Youth measure (PRaCY). Interviews were recorded, transcribed, and analyzed by two independent raters using a conventional content analysis approach. All participants reported at least one incident of racial bias. Content analysis of racial bias events (n = 104) yielded 4 categories and 12 subcategories as follows: Perpetrator (Peers, Authority Figures, and General Public), Type of Racial Bias (Explicit, Implicit), Behavioral Reaction (Approach, Avoidant), and Emotional Response (Dysphoria, Anger, Unconcerned, Inferior, Anxious). This study provides a description of racial bias experiences within community and medical settings and highlights the need for further evaluation of the impact of racial bias among youth with SCD.

Perturbed threat monitoring following a traumatic event predicts risk for post-traumatic stress disorder.

PubMed

Naim, R; Wald, I; Lior, A; Pine, D S; Fox, N A; Sheppes, G; Halpern, P; Bar-Haim, Y

2014-07-01

Post-traumatic stress disorder (PTSD) is a chronic and difficult to treat psychiatric disorder. Objective, performance-based diagnostic markers that uniquely index risk for PTSD above and beyond subjective self-report markers could inform attempts to improve prevention and early intervention. We evaluated the predictive value of threat-related attention bias measured immediately after a potentially traumatic event, as a risk marker for PTSD at a 3-month follow-up. We measured the predictive contribution of attentional threat bias above and beyond that of the more established marker of risk for PTSD, self-reported psychological dissociation. Dissociation symptoms and threat-related attention bias were measured in 577 motor vehicle accident (MVA) survivors (mean age = 35.02 years, 356 males) within 24 h of admission to an emergency department (ED) of a large urban hospital. PTSD symptoms were assessed at a 3-month follow-up using the Clinician-Administered PTSD Scale (CAPS). Self-reported dissociation symptoms significantly accounted for 16% of the variance in PTSD at follow-up, and attention bias toward threat significantly accounted for an additional 4% of the variance in PTSD. Threat-related attention bias can be reliably measured in the context of a hospital ED and significantly predicts risk for later PTSD. Possible mechanisms underlying the association between threat bias following a potentially traumatic event and risk for PTSD are discussed. The potential application of an attention bias modification treatment (ABMT) tailored to reduce risk for PTSD is suggested.

Immediacy bias in social-emotional comparisons.

PubMed

White, Katherine; Van Boven, Leaf

2012-08-01

In seven studies of naturally occurring, "real-world" emotional events, people demonstrated an immediacy bias in social-emotional comparisons, perceiving their own current or recent emotional reactions as more intense compared with others' emotional reactions to the same events. The events examined include crossing a scary bridge (study 1a), a national tragedy (study 1b), terrorist attacks (studies 2a and 3b), a natural disaster (study 2b), and a presidential election (study 3b). These perceived differences between one's own and others' emotions declined over time, as relatively immediate and recent emotions subsided, a pattern that people were not intuitively aware of (study 2c). This immediacy bias in social-emotional comparisons emerged for both explicit comparisons (studies 1a, 1b, and 3b), and for absolute judgments of emotional intensity (studies 2a, 2b, and 3a). Finally, the immediacy bias in social-emotional comparisons was reduced when people were reminded that emotional display norms might lead others' appearances to understate emotional intensity (studies 3a and 3b). Implications of these findings for social-emotional phenomena are discussed.

Neural time course of threat-related attentional bias and interference in panic and obsessive-compulsive disorders.

PubMed

Thomas, Susan J; Gonsalvez, Craig J; Johnstone, Stuart J

2013-09-01

Attentional biases to threat are considered central to anxiety disorders, however physiological evidence of their nature and time course is lacking. Event-related potentials (ERPs) characterized sensory and cognitive changes while 20 outpatients with panic disorder (PD), 20 with obsessive-compulsive disorder (OCD), and 20 healthy controls (HCs) responded to the color (emotional Stroop task) or meaning of threatening and neutral stimuli. ERPs indicated larger P1 amplitude and longer N1 latency in OCD, and shorter P1 latency in PD, to threatening (versus neutral) stimuli, across instructions to attend to, or ignore, threat content. Emotional Stroop interference correlated with phobic anxiety and was significant in PD. Participants with emotional Stroop interference had augmented P1 and P3 amplitudes to threat (versus neutral) stimuli when color-naming. The results suggest early attentional biases to threat in both disorders, with disorder-specific characteristics. ERPs supported preferential early attentional capture and cognitive elaboration hypotheses of emotional Stroop interference. Copyright © 2013 Elsevier B.V. All rights reserved.

The effects of voluntary running exercise coincidence with social isolation after early weaning on monoaminergic axonal development.

PubMed

Ishikawa, J; Ishikawa, A

2013-01-29

The axonal development of serotonin (5-HT)-, noradrenaline (NA)-, or tyrosine hydroxylase (TH)-containing monoaminergic neurons is affected by rearing conditions during the juvenile period. Impaired monoaminergic axonal development is implicated in the pathophysiology of emotional and cognitive dysfunction. On the other hand, exercise may have beneficial effects on emotional and learning performance in adults. We have examined whether voluntary running exercise during social isolation after early weaning (early weaning/social isolation; EI) from postnatal day (PD) 14-28 could prevent the impaired monoaminergic axonal development associated with EI. Compared with control animals reared with their dam and siblings until PD28, the EI animals showed lower density of 5-HT and NA axons in the dorsal-medial prefrontal cortex (mPFC) and basolateral nucleus of the amygdala and of NA- and TH-containing axons in the ventral-mPFC. These adverse effects of EI were not observed in rats taking part in voluntary running (EI+R) when these animals were compared to controls. The 5-HT axon density in the ventral-mPFC was significantly higher in the EI+R rats than that in the EI rats, although both these values were significantly lower than those in the control rats. The density of monoaminergic axons in the dentate gyrus and CA3 of the hippocampus was not affected by either EI or EI+R. These results suggest that the beneficial effects of voluntary running may be because of the modulation of monoaminergic axonal morphology. Our findings will hopefully provide the basis for future research into the beneficial effects of voluntary exercise during the juvenile period on brain development and emotional and cognitive performance. Copyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved.

[Comparison of the "Trigger" tool with the minimum basic data set for detecting adverse events in general surgery].

PubMed

Pérez Zapata, A I; Gutiérrez Samaniego, M; Rodríguez Cuéllar, E; Gómez de la Cámara, A; Ruiz López, P

Surgery is a high risk for the occurrence of adverse events (AE). The main objective of this study is to compare the effectiveness of the Trigger tool with the Hospital National Health System registration of Discharges, the minimum basic data set (MBDS), in detecting adverse events in patients admitted to General Surgery and undergoing surgery. Observational and descriptive retrospective study of patients admitted to general surgery of a tertiary hospital, and undergoing surgery in 2012. The identification of adverse events was made by reviewing the medical records, using an adaptation of "Global Trigger Tool" methodology, as well as the (MBDS) registered on the same patients. Once the AE were identified, they were classified according to damage and to the extent to which these could have been avoided. The area under the curve (ROC) were used to determine the discriminatory power of the tools. The Hanley and Mcneil test was used to compare both tools. AE prevalence was 36.8%. The TT detected 89.9% of all AE, while the MBDS detected 28.48%. The TT provides more information on the nature and characteristics of the AE. The area under the curve was 0.89 for the TT and 0.66 for the MBDS. These differences were statistically significant (P<.001). The Trigger tool detects three times more adverse events than the MBDS registry. The prevalence of adverse events in General Surgery is higher than that estimated in other studies. Copyright © 2017 SECA. Publicado por Elsevier España, S.L.U. All rights reserved.

Motion, identity and the bias toward agency

PubMed Central

Fields, Chris

2014-01-01

The well-documented human bias toward agency as a cause and therefore an explanation of observed events is typically attributed to evolutionary selection for a “social brain”. Based on a review of developmental and adult behavioral and neurocognitive data, it is argued that the bias toward agency is a result of the default human solution, developed during infancy, to the computational requirements of object re-identification over gaps in observation of more than a few seconds. If this model is correct, overriding the bias toward agency to construct mechanistic explanations of observed events requires structure-mapping inferences, implemented by the pre-motor action planning system, that replace agents with mechanisms as causes of unobserved changes in contextual or featural properties of objects. Experiments that would test this model are discussed. PMID:25191245

Charged particle multiplicities in pp interactions at sqrt {s} = 0.9 , 2.36, and 7 TeV

NASA Astrophysics Data System (ADS)

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A.; Sonnenschein, L.; Steggemann, J.; Teyssier, D.; Bontenackels, M.; Davids, M.; Duda, M.; Flügge, G.; Geenen, H.; Giffels, M.; Haj Ahmad, W.; Heydhausen, D.; Kress, T.; Kuessel, Y.; Linn, A.; Nowack, A.; Perchalla, L.; Pooth, O.; Rennefeld, J.; Sauerland, P.; Stahl, A.; Thomas, M.; Tornier, D.; Zoeller, M. H.; Aldaya Martin, M.; Behrenhoff, W.; Behrens, U.; Bergholz, M.; Borras, K.; Cakir, A.; Campbell, A.; Castro, E.; Dammann, D.; Eckerlin, G.; Eckstein, D.; Flossdorf, A.; Flucke, G.; Geiser, A.; Glushkov, I.; Hauk, J.; Jung, H.; Kasemann, M.; Katkov, I.; Katsas, P.; Kleinwort, C.; Kluge, H.; Knutsson, A.; Krücker, D.; Kuznetsova, E.; Lange, W.; Lohmann, W.; Mankel, R.; Marienfeld, M.; Melzer-Pellmann, I.-A.; Meyer, A. B.; Mnich, J.; Mussgiller, A.; Olzem, J.; Parenti, A.; Raspereza, A.; Raval, A.; Schmidt, R.; Schoerner-Sadenius, T.; Sen, N.; Stein, M.; Tomaszewska, J.; Volyanskyy, D.; Walsh, R.; Wissing, C.; Autermann, C.; Bobrovskyi, S.; Draeger, J.; Enderle, H.; Gebbert, U.; Kaschube, K.; Kaussen, G.; Klanner, R.; Mura, B.; Naumann-Emme, S.; Nowak, F.; Pietsch, N.; Sander, C.; Schettler, H.; Schleper, P.; Schröder, M.; Schum, T.; Schwandt, J.; Srivastava, A. K.; Stadie, H.; Steinbrück, G.; Thomsen, J.; Wolf, R.; Bauer, J.; Buege, V.; Chwalek, T.; De Boer, W.; Dierlamm, A.; Dirkes, G.; Feindt, M.; Gruschke, J.; Hackstein, C.; Hartmann, F.; Heindl, S. M.; Heinrich, M.; Held, H.; Hoffmann, K. H.; Honc, S.; Kuhr, T.; Martschei, D.; Mueller, S.; Müller, Th.; Niegel, M.; Oberst, O.; Oehler, A.; Ott, J.; Peiffer, T.; Piparo, D.; Quast, G.; Rabbertz, K.; Ratnikov, F.; Renz, M.; Saout, C.; Scheurer, A.; Schieferdecker, P.; Schilling, F.-P.; Schott, G.; Simonis, H. J.; Stober, F. 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M.; Shukla, P.; Suggisetti, P.; Aziz, T.; Guchait, M.; Gurtu, A.; Maity, M.; Majumder, D.; Majumder, G.; Mazumdar, K.; Mohanty, G. B.; Saha, A.; Sudhakar, K.; Wickramage, N.; Banerjee, S.; Dugad, S.; Mondal, N. K.; Arfaei, H.; Bakhshiansohi, H.; Etesami, S. M.; Fahim, A.; Hashemi, M.; Jafari, A.; Khakzad, M.; Mohammadi, A.; Mohammadi Najafabadi, M.; Paktinat Mehdiabadi, S.; Safarzadeh, B.; Zeinali, M.; Abbrescia, M.; Barbone, L.; Calabria, C.; Colaleo, A.; Creanza, D.; De Filippis, N.; De Palma, M.; Dimitrov, A.; Fedele, F.; Fiore, L.; Iaselli, G.; Lusito, L.; Maggi, G.; Maggi, M.; Manna, N.; Marangelli, B.; My, S.; Nuzzo, S.; Pacifico, N.; Pierro, G. A.; Pompili, A.; Pugliese, G.; Romano, F.; Roselli, G.; Selvaggi, G.; Silvestris, L.; Trentadue, R.; Tupputi, S.; Zito, G.; Abbiendi, G.; Benvenuti, A. C.; Bonacorsi, D.; Braibant-Giacomelli, S.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Cuffiani, M.; Dallavalle, G. 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M.; Lista, L.; Merola, M.; Noli, P.; Paolucci, P.; Azzi, P.; Bacchetta, N.; Bellan, P.; Biasotto, M.; Bisello, D.; Branca, A.; Carlin, R.; Checchia, P.; Conti, E.; De Mattia, M.; Dorigo, T.; Fanzago, F.; Gasparini, F.; Giubilato, P.; Gresele, A.; Lacaprara, S.; Lazzizzera, I.; Margoni, M.; Meneguzzo, A. T.; Nespolo, M.; Perrozzi, L.; Pozzobon, N.; Ronchese, P.; Simonetto, F.; Torassa, E.; Tosi, M.; Vanini, S.; Ventura, S.; Zotto, P.; Zumerle, G.; Baesso, P.; Berzano, U.; Riccardi, C.; Torre, P.; Vitulo, P.; Viviani, C.; Biasini, M.; Bilei, G. M.; Caponeri, B.; Fanò, L.; Lariccia, P.; Lucaroni, A.; Mantovani, G.; Menichelli, M.; Nappi, A.; Santocchia, A.; Servoli, L.; Taroni, S.; Valdata, M.; Volpe, R.; Azzurri, P.; Bagliesi, G.; Bernardini, J.; Boccali, T.; Broccolo, G.; Castaldi, R.; D'Agnolo, R. T.; Dell'Orso, R.; Fiori, F.; Foà, L.; Giassi, A.; Kraan, A.; Ligabue, F.; Lomtadze, T.; Martini, L.; Messineo, A.; Palla, F.; Palmonari, F.; Sarkar, S.; Segneri, G.; Serban, A. T.; Spagnolo, P.; Tenchini, R.; Tonelli, G.; Venturi, A.; Verdini, P. G.; Barone, L.; Cavallari, F.; Del Re, D.; Di Marco, E.; Diemoz, M.; Franci, D.; Grassi, M.; Longo, E.; Organtini, G.; Palma, A.; Pandolfi, F.; Paramatti, R.; Rahatlou, S.; Amapane, N.; Arcidiacono, R.; Argiro, S.; Arneodo, M.; Biino, C.; Botta, C.; Cartiglia, N.; Castello, R.; Costa, M.; Demaria, N.; Graziano, A.; Mariotti, C.; Marone, M.; Maselli, S.; Migliore, E.; Mila, G.; Monaco, V.; Musich, M.; Obertino, M. M.; Pastrone, N.; Pelliccioni, M.; Romero, A.; Ruspa, M.; Sacchi, R.; Sola, V.; Solano, A.; Staiano, A.; Trocino, D.; Vilela Pereira, A.; Ambroglini, F.; Belforte, S.; Cossutti, F.; Della Ricca, G.; Gobbo, B.; Montanino, D.; Penzo, A.; Heo, S. G.; Chang, S.; Chung, J.; Kim, D. H.; Kim, G. N.; Kim, J. E.; Kong, D. J.; Park, H.; Son, D.; Son, D. C.; Kim, Zero; Kim, J. Y.; Song, S.; Choi, S.; Hong, B.; Jo, M.; Kim, H.; Kim, J. H.; Kim, T. J.; Lee, K. S.; Moon, D. H.; Park, S. K.; Rhee, H. 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G.; Gallinaro, M.; Martins, P.; Musella, P.; Nayak, A.; Ribeiro, P. Q.; Seixas, J.; Silva, P.; Varela, J.; Wöhri, H. K.; Belotelov, I.; Bunin, P.; Finger, M.; Finger, M.; Golutvin, I.; Kamenev, A.; Karjavin, V.; Kozlov, G.; Lanev, A.; Moisenz, P.; Palichik, V.; Perelygin, V.; Shmatov, S.; Smirnov, V.; Volodko, A.; Zarubin, A.; Bondar, N.; Golovtsov, V.; Ivanov, Y.; Kim, V.; Levchenko, P.; Murzin, V.; Oreshkin, V.; Smirnov, I.; Sulimov, V.; Uvarov, L.; Vavilov, S.; Vorobyev, A.; Andreev, Yu.; Gninenko, S.; Golubev, N.; Kirsanov, M.; Krasnikov, N.; Matveev, V.; Pashenkov, A.; Toropin, A.; Troitsky, S.; Epshteyn, V.; Gavrilov, V.; Kaftanov, V.; Kossov, M.; Krokhotin, A.; Lychkovskaya, N.; Safronov, G.; Semenov, S.; Stolin, V.; Vlasov, E.; Zhokin, A.; Boos, E.; Dubinin, M.; Dudko, L.; Ershov, A.; Gribushin, A.; Kodolova, O.; Lokhtin, I.; Obraztsov, S.; Petrushanko, S.; Sarycheva, L.; Savrin, V.; Snigirev, A.; Andreev, V.; Azarkin, M.; Dremin, I.; Kirakosyan, M.; Rusakov, S. V.; Vinogradov, A.; Azhgirey, I.; Bitioukov, S.; Grishin, V.; Kachanov, V.; Konstantinov, D.; Korablev, A.; Krychkine, V.; Petrov, V.; Ryutin, R.; Slabospitsky, S.; Sobol, A.; Tourtchanovitch, L.; Troshin, S.; Tyurin, N.; Uzunian, A.; Volkov, A.; Adzic, P.; Djordjevic, M.; Krpic, D.; Milosevic, J.; Aguilar-Benitez, M.; Alcaraz Maestre, J.; Arce, P.; Battilana, C.; Calvo, E.; Cepeda, M.; Cerrada, M.; Colino, N.; De La Cruz, B.; Diez Pardos, C.; Fernandez Bedoya, C.; Fernández Ramos, J. P.; Ferrando, A.; Flix, J.; Fouz, M. C.; Garcia-Abia, P.; Gonzalez Lopez, O.; Goy Lopez, S.; Hernandez, J. M.; Josa, M. I.; Merino, G.; Puerta Pelayo, J.; Redondo, I.; Romero, L.; Santaolalla, J.; Willmott, C.; Albajar, C.; Codispoti, G.; de Trocóniz, J. F.; Cuevas, J.; Fernandez Menendez, J.; Folgueras, S.; Gonzalez Caballero, I.; Lloret Iglesias, L.; Vizan Garcia, J. M.; Brochero Cifuentes, J. A.; Cabrillo, I. J.; Calderon, A.; Chamizo Llatas, M.; Chuang, S. H.; Duarte Campderros, J.; Felcini, M.; Fernandez, M.; Gomez, G.; Gonzalez Sanchez, J.; Gonzalez Suarez, R.; Jorda, C.; Lobelle Pardo, P.; Lopez Virto, A.; Marco, J.; Marco, R.; Martinez Rivero, C.; Matorras, F.; Munoz Sanchez, F. J.; Piedra Gomez, J.; Rodrigo, T.; Ruiz Jimeno, A.; Scodellaro, L.; Sobron Sanudo, M.; Vila, I.; Vilar Cortabitarte, R.; Abbaneo, D.; Auffray, E.; Auzinger, G.; Baillon, P.; Ball, A. H.; Barney, D.; Bell, A. J.; Benedetti, D.; Bernet, C.; Bialas, W.; Bloch, P.; Bocci, A.; Bolognesi, S.; Breuker, H.; Brona, G.; Bunkowski, K.; Camporesi, T.; Cano, E.; Cerminara, G.; Christiansen, T.; Coarasa Perez, J. A.; Covarelli, R.; Curé, B.; D'Enterria, D.; Dahms, T.; De Roeck, A.; Duarte Ramos, F.; Elliott-Peisert, A.; Funk, W.; Gaddi, A.; Gennai, S.; Georgiou, G.; Gerwig, H.; Gigi, D.; Gill, K.; Giordano, D.; Glege, F.; Gomez-Reino Garrido, R.; Gouzevitch, M.; Govoni, P.; Gowdy, S.; Guiducci, L.; Hansen, M.; Harvey, J.; Hegeman, J.; Hegner, B.; Henderson, C.; Hoffmann, H. F.; Honma, A.; Innocente, V.; Janot, P.; Karavakis, E.; Lecoq, P.; Leonidopoulos, C.; Lourenço, C.; Macpherson, A.; Mäki, T.; Malgeri, L.; Mannelli, M.; Masetti, L.; Meijers, F.; Mersi, S.; Meschi, E.; Moser, R.; Mozer, M. U.; Mulders, M.; Nesvold, E.; Nguyen, M.; Orimoto, T.; Orsini, L.; Perez, E.; Petrilli, A.; Pfeiffer, A.; Pierini, M.; Pimiä, M.; Polese, G.; Racz, A.; Rolandi, G.; Rommerskirchen, T.; Rovelli, C.; Rovere, M.; Sakulin, H.; Schäfer, C.; Schwick, C.; Segoni, I.; Sharma, A.; Siegrist, P.; Simon, M.; Sphicas, P.; Spiga, D.; Spiropulu, M.; Stöckli, F.; Stoye, M.; Tropea, P.; Tsirou, A.; Tsyganov, A.; Veres, G. I.; Vichoudis, P.; Voutilainen, M.; Zeuner, W. D.; Bertl, W.; Deiters, K.; Erdmann, W.; Gabathuler, K.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; König, S.; Kotlinski, D.; Langenegger, U.; Meier, F.; Renker, D.; Rohe, T.; Sibille, J.; Starodumov, A.; Bortignon, P.; Caminada, L.; Chen, Z.; Cittolin, S.; Dissertori, G.; Dittmar, M.; Eugster, J.; Freudenreich, K.; Grab, C.; Hervé, A.; Hintz, W.; Lecomte, P.; Lustermann, W.; Marchica, C.; del Arbol, P. Martinez Ruiz; Meridiani, P.; Milenovic, P.; Moortgat, F.; Nef, P.; Nessi-Tedaldi, F.; Pape, L.; Pauss, F.; Punz, T.; Rizzi, A.; Ronga, F. J.; Sala, L.; Sanchez, A. K.; Sawley, M. C.; Stieger, B.; Tauscher, L.; Thea, A.; Theofilatos, K.; Treille, D.; Urscheler, C.; Wallny, R.; Weber, M.; Wehrli, L.; Weng, J.; Aguiló, E.; Amsler, C.; Chiochia, V.; De Visscher, S.; Favaro, C.; Ivova Rikova, M.; Millan Mejias, B.; Regenfus, C.; Robmann, P.; Schmidt, A.; Snoek, H.; Wilke, L.; Chang, Y. H.; Chen, K. H.; Chen, W. T.; Dutta, S.; Go, A.; Kuo, C. M.; Li, S. W.; Lin, W.; Liu, M. H.; Liu, Z. K.; Lu, Y. J.; Wu, J. H.; Yu, S. S.; Bartalini, P.; Chang, P.; Chang, Y. H.; Chang, Y. W.; Chao, Y.; Chen, K. F.; Hou, W.-S.; Hsiung, Y.; Kao, K. Y.; Lei, Y. J.; Lu, R.-S.; Shiu, J. G.; Tzeng, Y. M.; Wang, M.; Adiguzel, A.; Bakirci, M. N.; Cerci, S.; Dozen, C.; Dumanoglu, I.; Eskut, E.; Girgis, S.; Gökbulut, G.; Güler, Y.; Gurpinar, E.; Hos, I.; Kangal, E. E.; Karaman, T.; Kayis Topaksu, A.; Nart, A.; Önengüt, G.; Ozdemir, K.; Ozturk, S.; Polatöz, A.; Sogut, K.; Tali, B.; Topakli, H.; Uzun, D.; Vergili, L. N.; Vergili, M.; Zorbilmez, C.; Akin, I. V.; Aliev, T.; Bimis, S.; Deniz, M.; Gamsizkan, H.; Guler, A. M.; Ocalan, K.; Ozpineci, A.; Serin, M.; Sever, R.; Surat, U. E.; Yildirim, E.; Zeyrek, M.; Deliomeroglu, M.; Demir, D.; Gülmez, E.; Halu, A.; Isildak, B.; Kaya, M.; Kaya, O.; Özbek, M.; Ozkorucuklu, S.; Sonmez, N.; Levchuk, L.; Bell, P.; Bostock, F.; Brooke, J. J.; Cheng, T. 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J.; Seez, C.; Sharp, P.; Sparrow, A.; Tapper, A.; Tourneur, S.; Vazquez Acosta, M.; Virdee, T.; Wakefield, S.; Wardrope, D.; Whyntie, T.; Barrett, M.; Chadwick, M.; Cole, J. E.; Hobson, P. R.; Khan, A.; Kyberd, P.; Leslie, D.; Martin, W.; Reid, I. D.; Teodorescu, L.; Hatakeyama, K.; Bose, T.; Carrera Jarrin, E.; Clough, A.; Fantasia, C.; Heister, A.; John, J. St.; Lawson, P.; Lazic, D.; Rohlf, J.; Sperka, D.; Sulak, L.; Avetisyan, A.; Bhattacharya, S.; Chou, J. P.; Cutts, D.; Esen, S.; Ferapontov, A.; Heintz, U.; Jabeen, S.; Kukartsev, G.; Landsberg, G.; Narain, M.; Nguyen, D.; Segala, M.; Speer, T.; Tsang, K. V.; Borgia, M. A.; Breedon, R.; De La Barca Sanchez, M. Calderon; Cebra, D.; Chauhan, S.; Chertok, M.; Conway, J.; Cox, P. T.; Dolen, J.; Erbacher, R.; Friis, E.; Ko, W.; Kopecky, A.; Lander, R.; Liu, H.; Maruyama, S.; Miceli, T.; Nikolic, M.; Pellett, D.; Robles, J.; Schwarz, T.; Searle, M.; Smith, J.; Squires, M.; Tripathi, M.; Vasquez Sierra, R.; Veelken, C.; Andreev, V.; Arisaka, K.; Cline, D.; Cousins, R.; Deisher, A.; Duris, J.; Erhan, S.; Farrell, C.; Hauser, J.; Ignatenko, M.; Jarvis, C.; Plager, C.; Rakness, G.; Schlein, P.; Tucker, J.; Valuev, V.; Babb, J.; Clare, R.; Ellison, J.; Gary, J. W.; Giordano, F.; Hanson, G.; Jeng, G. Y.; Kao, S. C.; Liu, F.; Liu, H.; Luthra, A.; Nguyen, H.; Pasztor, G.; Satpathy, A.; Shen, B. C.; Stringer, R.; Sturdy, J.; Sumowidagdo, S.; Wilken, R.; Wimpenny, S.; Andrews, W.; Branson, J. G.; Dusinberre, E.; Evans, D.; Golf, F.; Holzner, A.; Kelley, R.; Lebourgeois, M.; Letts, J.; Mangano, B.; Muelmenstaedt, J.; Padhi, S.; Palmer, C.; Petrucciani, G.; Pi, H.; Pieri, M.; Ranieri, R.; Sani, M.; Sharma, V.; Simon, S.; Tu, Y.; Vartak, A.; Würthwein, F.; Yagil, A.; Barge, D.; Bellan, R.; Campagnari, C.; D'Alfonso, M.; Danielson, T.; Geffert, P.; Incandela, J.; Justus, C.; Kalavase, P.; Koay, S. A.; Kovalskyi, D.; Krutelyov, V.; Lowette, S.; Mccoll, N.; Pavlunin, V.; Rebassoo, F.; Ribnik, J.; Richman, J.; Rossin, R.; Stuart, D.; To, W.; Vlimant, J. R.; Bornheim, A.; Bunn, J.; Chen, Y.; Gataullin, M.; Kcira, D.; Litvine, V.; Ma, Y.; Mott, A.; Newman, H. B.; Rogan, C.; Timciuc, V.; Traczyk, P.; Veverka, J.; Wilkinson, R.; Yang, Y.; Zhu, R. Y.; Akgun, B.; Carroll, R.; Ferguson, T.; Iiyama, Y.; Jang, D. W.; Jun, S. Y.; Liu, Y. F.; Paulini, M.; Russ, J.; Terentyev, N.; Vogel, H.; Vorobiev, I.; Cumalat, J. P.; Dinardo, M. E.; Drell, B. R.; Edelmaier, C. J.; Ford, W. T.; Heyburn, B.; Luiggi Lopez, E.; Nauenberg, U.; Smith, J. G.; Stenson, K.; Ulmer, K. A.; Wagner, S. R.; Zang, S. L.; Agostino, L.; Alexander, J.; Chatterjee, A.; Das, S.; Eggert, N.; Fields, L. J.; Gibbons, L. K.; Heltsley, B.; Hopkins, W.; Khukhunaishvili, A.; Kreis, B.; Kuznetsov, V.; Nicolas Kaufman, G.; Patterson, J. R.; Puigh, D.; Riley, D.; Ryd, A.; Shi, X.; Sun, W.; Teo, W. D.; Thom, J.; Thompson, J.; Vaughan, J.; Weng, Y.; Winstrom, L.; Wittich, P.; Biselli, A.; Cirino, G.; Winn, D.; Abdullin, S.; Albrow, M.; Anderson, J.; Apollinari, G.; Atac, M.; Bakken, J. A.; Banerjee, S.; Bauerdick, L. A. T.; Beretvas, A.; Berryhill, J.; Bhat, P. C.; Bloch, I.; Borcherding, F.; Burkett, K.; Butler, J. N.; Chetluru, V.; Cheung, H. W. K.; Chlebana, F.; Cihangir, S.; Demarteau, M.; Eartly, D. P.; Elvira, V. D.; Fisk, I.; Freeman, J.; Gao, Y.; Gottschalk, E.; Green, D.; Gunthoti, K.; Gutsche, O.; Hahn, A.; Hanlon, J.; Harris, R. M.; Hirschauer, J.; Hooberman, B.; James, E.; Jensen, H.; Johnson, M.; Joshi, U.; Khatiwada, R.; Kilminster, B.; Klima, B.; Kousouris, K.; Kunori, S.; Kwan, S.; Limon, P.; Lipton, R.; Lykken, J.; Maeshima, K.; Marraffino, J. M.; Mason, D.; McBride, P.; McCauley, T.; Miao, T.; Mishra, K.; Mrenna, S.; Musienko, Y.; Newman-Holmes, C.; O'Dell, V.; Popescu, S.; Pordes, R.; Prokofyev, O.; Saoulidou, N.; Sexton-Kennedy, E.; Sharma, S.; Soha, A.; Spalding, W. J.; Spiegel, L.; Tan, P.; Taylor, L.; Tkaczyk, S.; Uplegger, L.; Vaandering, E. W.; Vidal, R.; Whitmore, J.; Wu, W.; Yang, F.; Yumiceva, F.; Yun, J. C.; Acosta, D.; Avery, P.; Bourilkov, D.; Chen, M.; Di Giovanni, G. P.; Dobur, D.; Drozdetskiy, A.; Field, R. D.; Fisher, M.; Fu, Y.; Furic, I. K.; Gartner, J.; Goldberg, S.; Kim, B.; Klimenko, S.; Konigsberg, J.; Korytov, A.; Kropivnitskaya, A.; Kypreos, T.; Matchev, K.; Mitselmakher, G.; Muniz, L.; Pakhotin, Y.; Prescott, C.; Remington, R.; Schmitt, M.; Scurlock, B.; Sellers, P.; Skhirtladze, N.; Wang, D.; Yelton, J.; Zakaria, M.; Ceron, C.; Gaultney, V.; Kramer, L.; Lebolo, L. M.; Linn, S.; Markowitz, P.; Martinez, G.; Rodriguez, J. L.; Adams, T.; Askew, A.; Bandurin, D.; Bochenek, J.; Chen, J.; Diamond, B.; Gleyzer, S. V.; Haas, J.; Hagopian, S.; Hagopian, V.; Jenkins, M.; Johnson, K. F.; Prosper, H.; Sekmen, S.; Veeraraghavan, V.; Baarmand, M. M.; Dorney, B.; Guragain, S.; Hohlmann, M.; Kaakhety, H.; Ralich, R.; Vodopiyanov, I.; Adams, M. R.; Anghel, I. M.; Apanasevich, L.; Bai, Y.; Bazterra, V. E.; Betts, R. R.; Callner, J.; Cavanaugh, R.; Dragoiu, C.; Garcia-Solis, E. J.; Gerber, C. E.; Hofman, D. J.; Khalatyan, S.; Lacroix, F.; O'Brien, C.; Silvestre, C.; Smoron, A.; Strom, D.; Varelas, N.; Akgun, U.; Albayrak, E. A.; Bilki, B.; Cankocak, K.; Clarida, W.; Duru, F.; Lae, C. K.; McCliment, E.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Moeller, A.; Nachtman, J.; Newsom, C. R.; Norbeck, E.; Olson, J.; Onel, Y.; Ozok, F.; Sen, S.; Wetzel, J.; Yetkin, T.; Yi, K.; Barnett, B. A.; Blumenfeld, B.; Bonato, A.; Eskew, C.; Fehling, D.; Giurgiu, G.; Gritsan, A. V.; Guo, Z. J.; Hu, G.; Maksimovic, P.; Rappoccio, S.; Swartz, M.; Tran, N. V.; Whitbeck, A.; Baringer, P.; Bean, A.; Benelli, G.; Grachov, O.; Murray, M.; Noonan, D.; Radicci, V.; Sanders, S.; Wood, J. S.; Zhukova, V.; Bolton, T.; Chakaberia, I.; Ivanov, A.; Makouski, M.; Maravin, Y.; Shrestha, S.; Svintradze, I.; Wan, Z.; Gronberg, J.; Lange, D.; Wright, D.; Baden, A.; Boutemeur, M.; Eno, S. C.; Ferencek, D.; Gomez, J. A.; Hadley, N. J.; Kellogg, R. G.; Kirn, M.; Lu, Y.; Mignerey, A. C.; Rossato, K.; Rumerio, P.; Santanastasio, F.; Skuja, A.; Temple, J.; Tonjes, M. B.; Tonwar, S. C.; Twedt, E.; Alver, B.; Bauer, G.; Bendavid, J.; Busza, W.; Butz, E.; Cali, I. A.; Chan, M.; Dutta, V.; Everaerts, P.; Gomez Ceballos, G.; Goncharov, M.; Hahn, K. A.; Harris, P.; Kim, Y.; Klute, M.; Lee, Y.-J.; Li, W.; Loizides, C.; Luckey, P. D.; Ma, T.; Nahn, S.; Paus, C.; Roland, C.; Roland, G.; Rudolph, M.; Stephans, G. S. F.; Sumorok, K.; Sung, K.; Wenger, E. A.; Xie, S.; Yang, M.; Yilmaz, Y.; Yoon, A. S.; Zanetti, M.; Cole, P.; Cooper, S. I.; Cushman, P.; Dahmes, B.; De Benedetti, A.; Dudero, P. R.; Franzoni, G.; Haupt, J.; Klapoetke, K.; Kubota, Y.; Mans, J.; Rekovic, V.; Rusack, R.; Sasseville, M.; Singovsky, A.; Cremaldi, L. M.; Godang, R.; Kroeger, R.; Perera, L.; Rahmat, R.; Sanders, D. A.; Summers, D.; Bloom, K.; Bose, S.; Butt, J.; Claes, D. R.; Dominguez, A.; Eads, M.; Keller, J.; Kelly, T.; Kravchenko, I.; Lazo-Flores, J.; Lundstedt, C.; Malbouisson, H.; Malik, S.; Snow, G. R.; Baur, U.; Godshalk, A.; Iashvili, I.; Kharchilava, A.; Kumar, A.; Smith, K.; Alverson, G.; Barberis, E.; Baumgartel, D.; Boeriu, O.; Chasco, M.; Kaadze, K.; Reucroft, S.; Swain, J.; Wood, D.; Zhang, J.; Anastassov, A.; Kubik, A.; Odell, N.; Ofierzynski, R. A.; Pollack, B.; Pozdnyakov, A.; Schmitt, M.; Stoynev, S.; Velasco, M.; Won, S.; Antonelli, L.; Berry, D.; Hildreth, M.; Jessop, C.; Karmgard, D. J.; Kolb, J.; Kolberg, T.; Lannon, K.; Luo, W.; Lynch, S.; Marinelli, N.; Morse, D. M.; Pearson, T.; Ruchti, R.; Slaunwhite, J.; Valls, N.; Warchol, J.; Wayne, M.; Ziegler, J.; Bylsma, B.; Durkin, L. S.; Gu, J.; Hill, C.; Killewald, P.; Kotov, K.; Ling, T. Y.; Rodenburg, M.; Williams, G.; Adam, N.; Berry, E.; Elmer, P.; Gerbaudo, D.; Halyo, V.; Hebda, P.; Hunt, A.; Jones, J.; Laird, E.; Lopes Pegna, D.; Marlow, D.; Medvedeva, T.; Mooney, M.; Olsen, J.; Piroué, P.; Quan, X.; Saka, H.; Stickland, D.; Tully, C.; Werner, J. S.; Zuranski, A.; Acosta, J. G.; Huang, X. T.; Lopez, A.; Mendez, H.; Oliveros, S.; Ramirez Vargas, J. E.; Zatserklyaniy, A.; Alagoz, E.; Barnes, V. E.; Bolla, G.; Borrello, L.; Bortoletto, D.; Everett, A.; Garfinkel, A. F.; Gecse, Z.; Gutay, L.; Jones, M.; Koybasi, O.; Laasanen, A. T.; Leonardo, N.; Liu, C.; Maroussov, V.; Merkel, P.; Miller, D. H.; Neumeister, N.; Potamianos, K.; Shipsey, I.; Silvers, D.; Svyatkovskiy, A.; Yoo, H. D.; Zablocki, J.; Zheng, Y.; Jindal, P.; Parashar, N.; Boulahouache, C.; Cuplov, V.; Ecklund, K. M.; Geurts, F. J. M.; Liu, J. H.; Morales, J.; Padley, B. P.; Redjimi, R.; Roberts, J.; Zabel, J.; Betchart, B.; Bodek, A.; Chung, Y. S.; de Barbaro, P.; Demina, R.; Eshaq, Y.; Flacher, H.; Garcia-Bellido, A.; Goldenzweig, P.; Gotra, Y.; Han, J.; Harel, A.; Miner, D. C.; Orbaker, D.; Petrillo, G.; Vishnevskiy, D.; Zielinski, M.; Bhatti, A.; Demortier, L.; Goulianos, K.; Lungu, G.; Mesropian, C.; Yan, M.; Atramentov, O.; Barker, A.; Duggan, D.; Gershtein, Y.; Gray, R.; Halkiadakis, E.; Hidas, D.; Hits, D.; Lath, A.; Panwalkar, S.; Patel, R.; Richards, A.; Rose, K.; Schnetzer, S.; Somalwar, S.; Stone, R.; Thomas, S.; Cerizza, G.; Hollingsworth, M.; Spanier, S.; Yang, Z. C.; York, A.; Asaadi, J.; Eusebi, R.; Gilmore, J.; Gurrola, A.; Kamon, T.; Khotilovich, V.; Montalvo, R.; Nguyen, C. N.; Pivarski, J.; Safonov, A.; Sengupta, S.; Tatarinov, A.; Toback, D.; Weinberger, M.; Akchurin, N.; Bardak, C.; Damgov, J.; Jeong, C.; Kovitanggoon, K.; Lee, S. W.; Mane, P.; Roh, Y.; Sill, A.; Volobouev, I.; Wigmans, R.; Yazgan, E.; Appelt, E.; Brownson, E.; Engh, D.; Florez, C.; Gabella, W.; Johns, W.; Kurt, P.; Maguire, C.; Mel, A.; Sheldon, P.; Velkovska, J.; Arenton, M. W.; Balazs, M.; Boutle, S.; Buehler, M.; Conetti, S.; Cox, B.; Francis, B.; Hirosky, R.; Ledovskoy, A.; Lin, C.; Neu, C.; Yohay, R.; Gollapinni, S.; Harr, R.; Karchin, P. E.; Mattson, M.; Milstène, C.; Sakharov, A.; Anderson, M.; Bachtis, M.; Bellinger, J. N.; Carlsmith, D.; Dasu, S.; Efron, J.; Gray, L.; Grogg, K. S.; Grothe, M.; Hall-Wilton, R.; Herndon, M.; Klabbers, P.; Klukas, J.; Lanaro, A.; Lazaridis, C.; Leonard, J.; Lomidze, D.; Loveless, R.; Mohapatra, A.; Parker, W.; Reeder, D.; Ross, I.; Savin, A.; Smith, W. H.; Swanson, J.; Weinberg, M.

2011-01-01

Measurements of primary charged hadron multiplicity distributions are presented for non-single-diffractive events in proton-proton collisions at centre-of-mass energies of sqrt {s} = 0.9 , 2.36, and 7 TeV, in five pseudorapidity ranges from | η| < 0 .5 to | η| < 2 .4. The data were collected with the minimum-bias trigger of the CMS experiment during the LHC commissioning runs in 2009 and the 7 TeV run in 2010. The multiplicity distribution at sqrt {s} = 0.9{text{TeV}} is in agreement with previous measurements. At higher energies the increase of the mean multiplicity with sqrt {s} is underestimated by most event generators. The average transverse momentum as a function of the multiplicity is also presented. The measurement of higher-order moments of the multiplicity distribution confirms the violation of Koba-Nielsen-Olesen scaling that has been observed at lower energies.

CCP MRAP Run

NASA Image and Video Library

2018-04-20

An MRAP armored vehicle goes through a training run on the Shuttle Landing Facility to support NASA's Commercial Crew Program at the agency's Kennedy Space Center in Florida. The 45,000-pound mine-resistant. The MRAP offers a mobile bunker for astronauts and ground crews in the unlikely event they have to get away from the launch pad quickly in an emergency.

29 CFR 4043.25 - Failure to make required minimum funding payment.

Code of Federal Regulations, 2013 CFR

2013-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.25 Failure to make required minimum funding payment. (a) Reportable event. A reportable event occurs when a required installment or a payment required under section 302 of ERISA or section 412...

29 CFR 4043.25 - Failure to make required minimum funding payment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.25 Failure to make required minimum funding payment. (a) Reportable event. A reportable event occurs when a required installment or a payment required under section 302 of ERISA or section 412...

29 CFR 4043.25 - Failure to make required minimum funding payment.

Code of Federal Regulations, 2012 CFR

2012-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.25 Failure to make required minimum funding payment. (a) Reportable event. A reportable event occurs when a required installment or a payment required under section 302 of ERISA or section 412...

29 CFR 4043.25 - Failure to make required minimum funding payment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.25 Failure to make required minimum funding payment. (a) Reportable event. A reportable event occurs when a required installment or a payment required under section 302 of ERISA or section 412...

Continuous event monitoring via a Bayesian predictive approach.

PubMed

Di, Jianing; Wang, Daniel; Brashear, H Robert; Dragalin, Vladimir; Krams, Michael

2016-01-01

In clinical trials, continuous monitoring of event incidence rate plays a critical role in making timely decisions affecting trial outcome. For example, continuous monitoring of adverse events protects the safety of trial participants, while continuous monitoring of efficacy events helps identify early signals of efficacy or futility. Because the endpoint of interest is often the event incidence associated with a given length of treatment duration (e.g., incidence proportion of an adverse event with 2 years of dosing), assessing the event proportion before reaching the intended treatment duration becomes challenging, especially when the event onset profile evolves over time with accumulated exposure. In particular, in the earlier part of the study, ignoring censored subjects may result in significant bias in estimating the cumulative event incidence rate. Such a problem is addressed using a predictive approach in the Bayesian framework. In the proposed approach, experts' prior knowledge about both the frequency and timing of the event occurrence is combined with observed data. More specifically, during any interim look, each event-free subject will be counted with a probability that is derived using prior knowledge. The proposed approach is particularly useful in early stage studies for signal detection based on limited information. But it can also be used as a tool for safety monitoring (e.g., data monitoring committee) during later stage trials. Application of the approach is illustrated using a case study where the incidence rate of an adverse event is continuously monitored during an Alzheimer's disease clinical trial. The performance of the proposed approach is also assessed and compared with other Bayesian and frequentist methods via simulation. Copyright © 2015 John Wiley & Sons, Ltd.

Competing risk bias was common in Kaplan-Meier risk estimates published in prominent medical journals.

PubMed

van Walraven, Carl; McAlister, Finlay A

2016-01-01

Risk estimates from Kaplan-Meier curves are well known to medical researchers, reviewers, and editors. In this study, we determined the proportion of Kaplan-Meier analyses published in prominent medical journals that are potentially biased because of competing events ("competing risk bias"). We randomly selected 100 studies that had at least one Kaplan-Meier analysis and were recently published in prominent medical journals. Susceptibility to competing risk bias was determined by examining the outcome and potential competing events. In susceptible studies, bias was quantified using a previously validated prediction model when the number of outcomes and competing events were given. Forty-six studies (46%) contained Kaplan-Meier analyses susceptible to competing risk bias. Sixteen studies (34.8%) susceptible to competing risk cited the number of outcomes and competing events; in six of these studies (6/16, 37.5%), the outcome risk from the Kaplan-Meier estimate (relative to the true risk) was biased upward by 10% or more. Almost half of Kaplan-Meier analyses published in medical journals are susceptible to competing risk bias and may overestimate event risk. This bias was found to be quantitatively important in a third of such studies. Copyright © 2016 Elsevier Inc. All rights reserved.

The contribution of natural variability to GCM bias: Can we effectively bias-correct climate projections?

NASA Astrophysics Data System (ADS)

McAfee, S. A.; DeLaFrance, A.

2017-12-01

Investigating the impacts of climate change often entails using projections from inherently imperfect general circulation models (GCMs) to drive models that simulate biophysical or societal systems in great detail. Error or bias in the GCM output is often assessed in relation to observations, and the projections are adjusted so that the output from impacts models can be compared to historical or observed conditions. Uncertainty in the projections is typically accommodated by running more than one future climate trajectory to account for differing emissions scenarios, model simulations, and natural variability. The current methods for dealing with error and uncertainty treat them as separate problems. In places where observed and/or simulated natural variability is large, however, it may not be possible to identify a consistent degree of bias in mean climate, blurring the lines between model error and projection uncertainty. Here we demonstrate substantial instability in mean monthly temperature bias across a suite of GCMs used in CMIP5. This instability is greatest in the highest latitudes during the cool season, where shifts from average temperatures below to above freezing could have profound impacts. In models with the greatest degree of bias instability, the timing of regional shifts from below to above average normal temperatures in a single climate projection can vary by about three decades, depending solely on the degree of bias assessed. This suggests that current bias correction methods based on comparison to 20- or 30-year normals may be inappropriate, particularly in the polar regions.

Exogenous testosterone affects early threat processing in socially anxious and healthy women.

PubMed

van Peer, Jacobien M; Enter, Dorien; van Steenbergen, Henk; Spinhoven, Philip; Roelofs, Karin

2017-10-01

Testosterone plays an important role in social threat processing. Recent evidence suggests that testosterone administration has socially anxiolytic effects, but it remains unknown whether this involves early vigilance or later, more sustained, processing-stages. We investigated the acute effects of testosterone administration on social threat processing in 19 female patients with Social Anxiety Disorder (SAD) and 19 healthy controls. Event-related potentials (ERPs) were recorded during an emotional Stroop task with subliminally presented faces. Testosterone induced qualitative changes in early ERPs (<200ms after stimulus onset) in both groups. An initial testosterone-induced spatial shift reflected a change in the basic processing (N170/VPP) of neutral faces, which was followed by a shift for angry faces suggesting a decrease in early threat bias. These findings suggest that testosterone specifically affects early automatic social information processing. The decreased attentional bias for angry faces explains how testosterone can decrease threat avoidance, which is particularly relevant for SAD. Copyright © 2017 Elsevier B.V. All rights reserved.

Impact Constraints on Major Events in Early Mars History

NASA Technical Reports Server (NTRS)

Frey, H. V.

2004-01-01

MOLA data have revealed a large population of "Quasi-Circular Depressions" (QCDs) with little or no visible expression in image data. These likely buried impact basins have important implications for the age of the lowland crust, how that compares with original highland crust, and when and how the crustal dichotomy may have formed. The buried lowlands are of Early Noachian age, likely slightly younger than the buried highlands but older than the exposed (visible) highland surface. A depopulation of large visible basins at diameters 800 to 1300 km suggests some global scale event early in martian history, maybe related to the formation of the lowlands and/or the development of Tharsis. A suggested early disappearance of the global magnetic field can be placed within a temporal sequence of formation of the very largest impact basins. The global field appears to have disappeared at about the time the lowlands formed. It seems likely the topographic crustal dichotomy was produced very early in martian history by processes which operated very quickly. Thus there appears to have been a northern lowland throughout nearly all of martian history, predating the last of the really large impacts (Hellas, Argyre and Isidis) and their likely very significant environmental consequences.

Estimating the urban bias of surface shelter temperatures using upper-air and satellite data. Part 2: Estimation of the urban bias

NASA Technical Reports Server (NTRS)

Epperson, David L.; Davis, Jerry M.; Bloomfield, Peter; Karl, Thomas R.; Mcnab, Alan L.; Gallo, Kevin P.

1995-01-01

A methodology is presented for estimating the urban bias of surface shelter temperatures due to the effect of the urban heat island. Multiple regression techniques were used to predict surface shelter temperatures based on the time period 1986-89 using upper-air data from the European Centre for Medium-Range Weather Forecasts (ECMWF) to represent the background climate, site-specific data to represent the local landscape, and satellite-derived data -- the normalized difference vegetation index (NDVI) and the Defense Meteorological Satellite Program (DMSP) nighttime brightness data -- to represent the urban and rural landscape. Local NDVI and DMSP values were calculated for each station using the mean NDVI and DMSP values from a 3 km x 3 km area centered over the given station. Regional NDVI and DMSP values were calculated to represent a typical rural value for each station using the mean NDVI and DMSP values from a 1 deg x 1 deg latitude-longitude area in which the given station was located. Models for the United States were then developed for monthly maximum, mean, and minimum temperatures using data from over 1000 stations in the U.S. Cooperative (COOP) Network and for monthly mean temperatures with data from over 1150 stations in the Global Historical Climate Network (GHCN). Local biases, or the differences between the model predictions using the observed NDVI and DMSP values, and the predictions using the background regional values were calculated and compared with the results of other research. The local or urban bias of U.S. temperatures, as derived from all U.S. stations (urban and rural) used in the models, averaged near 0.40 C for monthly minimum temperatures, near 0.25 C for monthly mean temperatures, and near 0.10 C for monthly maximum temperatures. The biases of monthly minimum temperatures for individual stations ranged from near -1.1 C for rural stations to 2.4 C for stations from the largest urban areas. The results of this study indicate minimal

Racial bias in empathy: Do we process dark- and fair-colored hands in pain differently? An EEG study.

PubMed

Fabi, Sarah; Leuthold, Hartmut

2018-06-01

The aim of this study was to identify racial bias influences on empathic processing from early stimulus encoding, over categorization until late motor processing stages by comparing brain responses (electroencephalogram) to pictures of fair- and dark-colored hands in painful or neutral daily-life situations. Participants performed a pain judgment task and a skin color judgment task. Event-related brain potentials (ERPs) substantiated former findings of automatic empathic influences on stimulus encoding, reflected by the early posterior negativity (EPN), and late controlled influences on the stimulus categorization, as reflected by the late posterior positivity (P3b). Concerning the racial bias in empathy (RBE) effect, more positive amplitudes in the 280-340 ms time window over frontocentral electrodes in the painful than the neutral condition for fair- but not dark-colored hands speak for an early influence of racial bias. This was further supported by correlations with empathic concern scores for fair- but not dark-colored stimuli. Additionally, P3b amplitude differences between fair- and dark-colored hands to painful stimuli increased with the implicit racial attitude of participants, suggesting that the categorization stage is not completely immune to racial bias. Regarding the motor processing stages, power change values in the upper beta-band (19-30 Hz) revealed for painful compared to neutral stimuli larger facilitation of sensorimotor activity before the response and larger inhibition after the response, independent of skin color. In conclusion, present findings speak for an influence of the RBE on early perceptual encoding but also on the late categorization stage that depends on the participant's implicit attitude towards racial outgroups. Copyright © 2018 Elsevier Ltd. All rights reserved.

Dose and Effect Thresholds for Early Key Events in a Mode of PPARa-Mediated Action

EPA Science Inventory

ABSTRACT Strategies for predicting adverse health outcomes of environmental chemicals are centered on early key events in toxicity pathways. However, quantitative relationships between early molecular changes in a given pathway and later health effects are often poorly defined. T...

Expectancy bias in anxious samples

PubMed Central

Cabeleira, Cindy M.; Steinman, Shari A.; Burgess, Melissa M.; Bucks, Romola S.; MacLeod, Colin; Melo, Wilson; Teachman, Bethany A.

2014-01-01

While it is well documented that anxious individuals have negative expectations about the future, it is unclear what cognitive processes give rise to this expectancy bias. Two studies are reported that use the Expectancy Task, which is designed to assess expectancy bias and illuminate its basis. This task presents individuals with valenced scenarios (Positive Valence, Negative Valence, or Conflicting Valence), and then evaluates their tendency to expect subsequent future positive relative to negative events. The Expectancy Task was used with low and high trait anxious (Study 1: N = 32) and anxiety sensitive (Study 2: N = 138) individuals. Results suggest that in the context of physical concerns, both high anxious samples display a less positive expectancy bias. In the context of social concerns, high trait anxious individuals display a negative expectancy bias only when negatively valenced information was previously presented. Overall, this suggests that anxious individuals display a less positive expectancy bias, and that the processes that give rise to this bias may vary by type of situation (e.g., social or physical) or anxiety difficulty. PMID:24798678

Evaluation of Statistical Downscaling Skill at Reproducing Extreme Events

NASA Astrophysics Data System (ADS)

McGinnis, S. A.; Tye, M. R.; Nychka, D. W.; Mearns, L. O.

2015-12-01

Climate model outputs usually have much coarser spatial resolution than is needed by impacts models. Although higher resolution can be achieved using regional climate models for dynamical downscaling, further downscaling is often required. The final resolution gap is often closed with a combination of spatial interpolation and bias correction, which constitutes a form of statistical downscaling. We use this technique to downscale regional climate model data and evaluate its skill in reproducing extreme events. We downscale output from the North American Regional Climate Change Assessment Program (NARCCAP) dataset from its native 50-km spatial resolution to the 4-km resolution of University of Idaho's METDATA gridded surface meterological dataset, which derives from the PRISM and NLDAS-2 observational datasets. We operate on the major variables used in impacts analysis at a daily timescale: daily minimum and maximum temperature, precipitation, humidity, pressure, solar radiation, and winds. To interpolate the data, we use the patch recovery method from the Earth System Modeling Framework (ESMF) regridding package. We then bias correct the data using Kernel Density Distribution Mapping (KDDM), which has been shown to exhibit superior overall performance across multiple metrics. Finally, we evaluate the skill of this technique in reproducing extreme events by comparing raw and downscaled output with meterological station data in different bioclimatic regions according to the the skill scores defined by Perkins et al in 2013 for evaluation of AR4 climate models. We also investigate techniques for improving bias correction of values in the tails of the distributions. These techniques include binned kernel density estimation, logspline kernel density estimation, and transfer functions constructed by fitting the tails with a generalized pareto distribution.

Spiral biasing adaptor for use in Si drift detectors and Si drift detector arrays

DOEpatents

Li, Zheng; Chen, Wei

2016-07-05

A drift detector array, preferably a silicon drift detector (SDD) array, that uses a low current biasing adaptor is disclosed. The biasing adaptor is customizable for any desired geometry of the drift detector single cell with minimum drift time of carriers. The biasing adaptor has spiral shaped ion-implants that generate the desired voltage profile. The biasing adaptor can be processed on the same wafer as the drift detector array and only one biasing adaptor chip/side is needed for one drift detector array to generate the voltage profiles on the front side and back side of the detector array.

Run-off regime of the small rivers in mountain landscapes (on an example of the mountain "Mongun-taiga

NASA Astrophysics Data System (ADS)

Pryahina, G.; Zelepukina, E.; Guzel, N.

2012-04-01

Hydrological characteristics calculations of the small mountain rivers in the basins with glaciers frequently cause complexity in connection with absence of standard hydrological supervision within remote mountain territories. The unique way of the actual information reception on a water mode of such rivers is field work. The rivers of the mountain Mongun-taiga located on a joint of Altai and Sayan mountains became hydrological researches objects of Russian geographical society complex expeditions in 2010-2011. The Mongun-taiga cluster of international biosphere reserve "Ubsunurskaya hollow" causes heightened interest of researchers — geographers for many years. The original landscape map in scale 1:100000 has been made, hydrological supervision on the rivers East Mugur and ugur, belonging inland basin of Internal Asia are lead. Supervision over the river drain East Mugur runoff were spent in profile of glacier tongue (the freezing area - 22 % (3.2 km2) from the reception basin) and in the closing alignment of the river located on distance of 3,4 km below tongue of glacier. During researches following results have been received. During the ablation period diurnal fluctuations with a strongly shown maximum and minimum of water discharges are typically for the small rivers with considerable share of a glacial food. The run-off maximum from the glacier takes place from 2 to 7 p.m., the run-off minimum is observed early in the morning. High speed of thawed snow running-off from glacier tongue and rather small volume of dynamic stocks water on an ice surface lead to growth of water discharge. In the bottom profile the time of maximum and minimum of water discharge is displaced on the average 2 hours, it depends of the water travel time. Maximum glacial run-off discharge (1.12 m3/s) in the upper profile was registered on July 16 (it was not rain). Volumes of daily runoff in the upper and bottom profiles were 60700-67600 m3 that day. The run-off from nonglacial part of

Selection bias in rheumatic disease research.

PubMed

Choi, Hyon K; Nguyen, Uyen-Sa; Niu, Jingbo; Danaei, Goodarz; Zhang, Yuqing

2014-07-01

The identification of modifiable risk factors for the development of rheumatic conditions and their sequelae is crucial for reducing the substantial worldwide burden of these diseases. However, the validity of such research can be threatened by sources of bias, including confounding, measurement and selection biases. In this Review, we discuss potentially major issues of selection bias--a type of bias frequently overshadowed by other bias and feasibility issues, despite being equally or more problematic--in key areas of rheumatic disease research. We present index event bias (a type of selection bias) as one of the potentially unifying reasons behind some unexpected findings, such as the 'risk factor paradox'--a phenomenon exemplified by the discrepant effects of certain risk factors on the development versus the progression of osteoarthritis (OA) or rheumatoid arthritis (RA). We also discuss potential selection biases owing to differential loss to follow-up in RA and OA research, as well as those due to the depletion of susceptibles (prevalent user bias) and immortal time bias. The lesson remains that selection bias can be ubiquitous and, therefore, has the potential to lead the field astray. Thus, we conclude with suggestions to help investigators avoid such issues and limit the impact on future rheumatology research.

Electrostatically Biased Binding of Kinesin to Microtubules

PubMed Central

Zheng, Wenjun; Alonso, Maria; Huber, Gary; Dlugosz, Maciej; McCammon, J. Andrew; Cross, Robert A.

2011-01-01

The minimum motor domain of kinesin-1 is a single head. Recent evidence suggests that such minimal motor domains generate force by a biased binding mechanism, in which they preferentially select binding sites on the microtubule that lie ahead in the progress direction of the motor. A specific molecular mechanism for biased binding has, however, so far been lacking. Here we use atomistic Brownian dynamics simulations combined with experimental mutagenesis to show that incoming kinesin heads undergo electrostatically guided diffusion-to-capture by microtubules, and that this produces directionally biased binding. Kinesin-1 heads are initially rotated by the electrostatic field so that their tubulin-binding sites face inwards, and then steered towards a plus-endwards binding site. In tethered kinesin dimers, this bias is amplified. A 3-residue sequence (RAK) in kinesin helix alpha-6 is predicted to be important for electrostatic guidance. Real-world mutagenesis of this sequence powerfully influences kinesin-driven microtubule sliding, with one mutant producing a 5-fold acceleration over wild type. We conclude that electrostatic interactions play an important role in the kinesin stepping mechanism, by biasing the diffusional association of kinesin with microtubules. PMID:22140358

Catastrophic event recorded among Holocene eolianites (Sidi Salem Formation, SE Tunisia)

NASA Astrophysics Data System (ADS)

Frébourg, Gregory; Hasler, Claude-Alain; Davaud, Eric

2010-03-01

A high-energy deposit cuts through the early Holocene eolianites of the Sidi Salem Formation which forms a ridge along the southeastern coast of Tunisia. The sedimentary structures as well as the paleo-altitude and paleo-location of the outcrop state for a subaqueous deposition by an unusually large catastrophic event. Regarding its age and the related uncertainties, it could be either an exceptional storm, or a landslide or impact triggered tsunami. The mega-tsunami of the 8000 BP collapse of the Valle del Bove valley (Etna Volcano) could be this event, for its matching age and calculated run-up height.

Characterizing rare-event property distributions via replicate molecular dynamics simulations of proteins.

PubMed

Krishnan, Ranjani; Walton, Emily B; Van Vliet, Krystyn J

2009-11-01

As computational resources increase, molecular dynamics simulations of biomolecules are becoming an increasingly informative complement to experimental studies. In particular, it has now become feasible to use multiple initial molecular configurations to generate an ensemble of replicate production-run simulations that allows for more complete characterization of rare events such as ligand-receptor unbinding. However, there are currently no explicit guidelines for selecting an ensemble of initial configurations for replicate simulations. Here, we use clustering analysis and steered molecular dynamics simulations to demonstrate that the configurational changes accessible in molecular dynamics simulations of biomolecules do not necessarily correlate with observed rare-event properties. This informs selection of a representative set of initial configurations. We also employ statistical analysis to identify the minimum number of replicate simulations required to sufficiently sample a given biomolecular property distribution. Together, these results suggest a general procedure for generating an ensemble of replicate simulations that will maximize accurate characterization of rare-event property distributions in biomolecules.

Nonlinear vs. linear biasing in Trp-cage folding simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spiwok, Vojtěch, E-mail: spiwokv@vscht.cz; Oborský, Pavel; Králová, Blanka

2015-03-21

Biased simulations have great potential for the study of slow processes, including protein folding. Atomic motions in molecules are nonlinear, which suggests that simulations with enhanced sampling of collective motions traced by nonlinear dimensionality reduction methods may perform better than linear ones. In this study, we compare an unbiased folding simulation of the Trp-cage miniprotein with metadynamics simulations using both linear (principle component analysis) and nonlinear (Isomap) low dimensional embeddings as collective variables. Folding of the mini-protein was successfully simulated in 200 ns simulation with linear biasing and non-linear motion biasing. The folded state was correctly predicted as the free energymore » minimum in both simulations. We found that the advantage of linear motion biasing is that it can sample a larger conformational space, whereas the advantage of nonlinear motion biasing lies in slightly better resolution of the resulting free energy surface. In terms of sampling efficiency, both methods are comparable.« less

Nonlinear vs. linear biasing in Trp-cage folding simulations

NASA Astrophysics Data System (ADS)

Spiwok, Vojtěch; Oborský, Pavel; Pazúriková, Jana; Křenek, Aleš; Králová, Blanka

2015-03-01

Biased simulations have great potential for the study of slow processes, including protein folding. Atomic motions in molecules are nonlinear, which suggests that simulations with enhanced sampling of collective motions traced by nonlinear dimensionality reduction methods may perform better than linear ones. In this study, we compare an unbiased folding simulation of the Trp-cage miniprotein with metadynamics simulations using both linear (principle component analysis) and nonlinear (Isomap) low dimensional embeddings as collective variables. Folding of the mini-protein was successfully simulated in 200 ns simulation with linear biasing and non-linear motion biasing. The folded state was correctly predicted as the free energy minimum in both simulations. We found that the advantage of linear motion biasing is that it can sample a larger conformational space, whereas the advantage of nonlinear motion biasing lies in slightly better resolution of the resulting free energy surface. In terms of sampling efficiency, both methods are comparable.

Nonlinear vs. linear biasing in Trp-cage folding simulations.

PubMed

Spiwok, Vojtěch; Oborský, Pavel; Pazúriková, Jana; Křenek, Aleš; Králová, Blanka

2015-03-21

Biased simulations have great potential for the study of slow processes, including protein folding. Atomic motions in molecules are nonlinear, which suggests that simulations with enhanced sampling of collective motions traced by nonlinear dimensionality reduction methods may perform better than linear ones. In this study, we compare an unbiased folding simulation of the Trp-cage miniprotein with metadynamics simulations using both linear (principle component analysis) and nonlinear (Isomap) low dimensional embeddings as collective variables. Folding of the mini-protein was successfully simulated in 200 ns simulation with linear biasing and non-linear motion biasing. The folded state was correctly predicted as the free energy minimum in both simulations. We found that the advantage of linear motion biasing is that it can sample a larger conformational space, whereas the advantage of nonlinear motion biasing lies in slightly better resolution of the resulting free energy surface. In terms of sampling efficiency, both methods are comparable.

Observations of Running Penumbral Waves Emerging in a Sunspot

NASA Astrophysics Data System (ADS)

Priya, T. G.; Wenda, Cao; Jiangtao, Su; Jie, Chen; Xinjie, Mao; Yuanyong, Deng; Robert, Erdélyi

2018-01-01

We present results from the investigation of 5 minute umbral oscillations in a single-polarity sunspot of active region NOAA 12132. The spectra of TiO, Hα, and 304 Å are used for corresponding atmospheric heights from the photosphere to lower corona. Power spectrum analysis at the formation height of Hα – 0.6 Å to the Hα center resulted in the detection of 5 minute oscillation signals in intensity interpreted as running waves outside the umbral center, mostly with vertical magnetic field inclination >15°. A phase-speed filter is used to extract the running wave signals with speed v ph > 4 km s‑1, from the time series of Hα – 0.4 Å images, and found twenty-four 3 minute umbral oscillatory events in a duration of one hour. Interestingly, the initial emergence of the 3 minute umbral oscillatory events are noticed closer to or at umbral boundaries. These 3 minute umbral oscillatory events are observed for the first time as propagating from a fraction of preceding running penumbral waves (RPWs). These fractional wavefronts rapidly separate from RPWs and move toward the umbral center, wherein they expand radially outwards suggesting the beginning of a new umbral oscillatory event. We found that most of these umbral oscillatory events develop further into RPWs. We speculate that the waveguides of running waves are twisted in spiral structures and hence the wavefronts are first seen at high latitudes of umbral boundaries and later at lower latitudes of the umbral center.

Running Injuries During Adolescence and Childhood.

PubMed

Krabak, Brian J; Snitily, Brian; Milani, Carlo J E

2016-02-01

The popularity of running among young athletes has significantly increased over the past few decades. As the number of children who participate in running increases, so do the potential number of injuries to this group. Proper care of these athletes includes a thorough understanding of the unique physiology of the skeletally immature athlete and common injuries in this age group. Treatment should focus on athlete education, modification of training schedule, and correction of biomechanical deficits contributing to injury. Early identification and correction of these factors will allow a safe return to running sports. Copyright © 2016 Elsevier Inc. All rights reserved.

Developmental Changes in the Whole Number Bias

ERIC Educational Resources Information Center

Braithwaite, David W.; Siegler, Robert S.

2017-01-01

Many students' knowledge of fractions is adversely affected by whole number bias, the tendency to focus on the separate whole number components (numerator and denominator) of a fraction rather than on the fraction's integrated magnitude (ratio of numerator to denominator). Although whole number bias appears early in the fraction learning process…

A bias-corrected CMIP5 dataset for Africa using the CDF-t method - a contribution to agricultural impact studies

NASA Astrophysics Data System (ADS)

Moise Famien, Adjoua; Janicot, Serge; Delfin Ochou, Abe; Vrac, Mathieu; Defrance, Dimitri; Sultan, Benjamin; Noël, Thomas

2018-03-01

The objective of this paper is to present a new dataset of bias-corrected CMIP5 global climate model (GCM) daily data over Africa. This dataset was obtained using the cumulative distribution function transform (CDF-t) method, a method that has been applied to several regions and contexts but never to Africa. Here CDF-t has been applied over the period 1950-2099 combining Historical runs and climate change scenarios for six variables: precipitation, mean near-surface air temperature, near-surface maximum air temperature, near-surface minimum air temperature, surface downwelling shortwave radiation, and wind speed, which are critical variables for agricultural purposes. WFDEI has been used as the reference dataset to correct the GCMs. Evaluation of the results over West Africa has been carried out on a list of priority user-based metrics that were discussed and selected with stakeholders. It includes simulated yield using a crop model simulating maize growth. These bias-corrected GCM data have been compared with another available dataset of bias-corrected GCMs using WATCH Forcing Data as the reference dataset. The impact of WFD, WFDEI, and also EWEMBI reference datasets has been also examined in detail. It is shown that CDF-t is very effective at removing the biases and reducing the high inter-GCM scattering. Differences with other bias-corrected GCM data are mainly due to the differences among the reference datasets. This is particularly true for surface downwelling shortwave radiation, which has a significant impact in terms of simulated maize yields. Projections of future yields over West Africa are quite different, depending on the bias-correction method used. However all these projections show a similar relative decreasing trend over the 21st century.

Sex-specific early survival drives adult sex ratio bias in snowy plovers and impacts mating system and population growth

PubMed Central

Küpper, Clemens; Miller, Tom E. X.; Cruz-López, Medardo; Maher, Kathryn H.; dos Remedios, Natalie; Stoffel, Martin A.; Hoffman, Joseph I.; Krüger, Oliver; Székely, Tamás

2017-01-01

Adult sex ratio (ASR) is a central concept in population biology and a key factor in sexual selection, but why do most demographic models ignore sex biases? Vital rates often vary between the sexes and across life history, but their relative contributions to ASR variation remain poorly understood—an essential step to evaluate sex ratio theories in the wild and inform conservation. Here, we combine structured two-sex population models with individual-based mark–recapture data from an intensively monitored polygamous population of snowy plovers. We show that a strongly male-biased ASR (0.63) is primarily driven by sex-specific survival of juveniles rather than adults or dependent offspring. This finding provides empirical support for theories of unbiased sex allocation when sex differences in survival arise after the period of parental investment. Importantly, a conventional model ignoring sex biases significantly overestimated population viability. We suggest that sex-specific population models are essential to understand the population dynamics of sexual organisms: reproduction and population growth are most sensitive to perturbations in survival of the limiting sex. Overall, our study suggests that sex-biased early survival may contribute toward mating system evolution and population persistence, with implications for both sexual selection theory and biodiversity conservation. PMID:28634289

Blunt splenic injury: are early adverse events related to trauma, nonoperative management, or surgery?

PubMed Central

Frandon, Julien; Rodiere, Mathieu; Arvieux, Catherine; Vendrell, Anne; Boussat, Bastien; Sengel, Christian; Broux, Christophe; Bricault, Ivan; Ferretti, Gilbert; Thony, Frédéric

2015-01-01

PURPOSE We aimed to compare clinical outcomes and early adverse events of operative management (OM), nonoperative management (NOM), and NOM with splenic artery embolization (SAE) in blunt splenic injury (BSI) and identify the prognostic factors. METHODS Medical records of 136 consecutive patients with BSI admitted to a trauma center from 2005 to 2010 were retrospectively reviewed. Patients were separated into three groups: OM, NOM, and SAE. We focused on associated injuries and early adverse events. Multivariate analysis was performed on 23 prognostic factors to find predictors. RESULTS The total survival rate was 97.1%, with four deaths all occurred in the OM group. The spleen salvage rate was 91% in NOM and SAE. At least one adverse event was observed in 32.8%, 62%, and 96% of patients in NOM, SAE, and OM groups, respectively (P < 0.001). We found significantly more deaths, infectious complications, pleural drainage, acute renal failures, and pancreatitis in OM and more pseudocysts in SAE. Six prognostic factors were statistically significant for one or more adverse events: simplified acute physiology score 2 ≥25 for almost all adverse events, age ≥50 years for acute respiratory syndrome, limb fracture for secondary bleeding, thoracic injury for pleural drainage, and at least one associated injury for pseudocyst. Adverse events were not related to the type of BSI management. CONCLUSION Patients with BSI present worse outcome and more adverse events in OM, but this is related to the severity of injury. The main predictor of adverse events remains the severity of injury. PMID:26081719

Blunt splenic injury: are early adverse events related to trauma, nonoperative management, or surgery?

PubMed

Frandon, Julien; Rodiere, Mathieu; Arvieux, Catherine; Vendrell, Anne; Boussat, Bastien; Sengel, Christian; Broux, Christophe; Bricault, Ivan; Ferretti, Gilbert; Thony, Frédéric

2015-01-01

We aimed to compare clinical outcomes and early adverse events of operative management (OM), nonoperative management (NOM), and NOM with splenic artery embolization (SAE) in blunt splenic injury (BSI) and identify the prognostic factors. Medical records of 136 consecutive patients with BSI admitted to a trauma center from 2005 to 2010 were retrospectively reviewed. Patients were separated into three groups: OM, NOM, and SAE. We focused on associated injuries and early adverse events. Multivariate analysis was performed on 23 prognostic factors to find predictors. The total survival rate was 97.1%, with four deaths all occurred in the OM group. The spleen salvage rate was 91% in NOM and SAE. At least one adverse event was observed in 32.8%, 62%, and 96% of patients in NOM, SAE, and OM groups, respectively (P < 0.001). We found significantly more deaths, infectious complications, pleural drainage, acute renal failures, and pancreatitis in OM and more pseudocysts in SAE. Six prognostic factors were statistically significant for one or more adverse events: simplified acute physiology score 2 ≥25 for almost all adverse events, age ≥50 years for acute respiratory syndrome, limb fracture for secondary bleeding, thoracic injury for pleural drainage, and at least one associated injury for pseudocyst. Adverse events were not related to the type of BSI management. Patients with BSI present worse outcome and more adverse events in OM, but this is related to the severity of injury. The main predictor of adverse events remains the severity of injury.

Selection bias in rheumatic disease research

PubMed Central

Choi, Hyon K.; Nguyen, Uyen-Sa; Niu, Jingbo; Danaei, Goodarz; Zhang, Yuqing

2014-01-01

The identification of modifiable risk factors for the development of rheumatic conditions and their sequelae is crucial for reducing the substantial worldwide burden of these diseases. However, the validity of such research can be threatened by sources of bias, including confounding, measurement and selection biases. In this Review, we discuss potentially major issues of selection bias—a type of bias frequently overshadowed by other bias and feasibility issues, despite being equally or more problematic—in key areas of rheumatic disease research. We present index event bias (a type of selection bias) as one of the potentially unifying reasons behind some unexpected findings, such as the ‘risk factor paradox’—a phenomenon exemplified by the discrepant effects of certain risk factors on the development versus the progression of osteoarthritis (OA) or rheumatoid arthritis (RA). We also discuss potential selection biases owing to differential loss to follow-up in RA and OA research, as well as those due to the depletion of susceptibles (prevalent user bias) and immortal time bias. The lesson remains that selection bias can be ubiquitous and, therefore, has the potential to lead the field astray. Thus, we conclude with suggestions to help investigators avoid such issues and limit the impact on future rheumatology research. PMID:24686510

On the impacts of computing daily temperatures as the average of the daily minimum and maximum temperatures

NASA Astrophysics Data System (ADS)

Villarini, Gabriele; Khouakhi, Abdou; Cunningham, Evan

2017-12-01

Daily temperature values are generally computed as the average of the daily minimum and maximum observations, which can lead to biases in the estimation of daily averaged values. This study examines the impacts of these biases on the calculation of climatology and trends in temperature extremes at 409 sites in North America with at least 25 years of complete hourly records. Our results show that the calculation of daily temperature based on the average of minimum and maximum daily readings leads to an overestimation of the daily values of 10+ % when focusing on extremes and values above (below) high (low) thresholds. Moreover, the effects of the data processing method on trend estimation are generally small, even though the use of the daily minimum and maximum readings reduces the power of trend detection ( 5-10% fewer trends detected in comparison with the reference data).

Developmental Changes in the Whole Number Bias

ERIC Educational Resources Information Center

Braithwaite, David W.; Siegler, Robert S.

2018-01-01

Many students' knowledge of fractions is adversely affected by whole number bias, the tendency to focus on the separate whole number components (numerator and denominator) of a fraction rather than on the fraction's magnitude (ratio of numerator to denominator). Although whole number bias appears early in the fraction learning process and under…

Affective Biases in Humans and Animals.

PubMed

Robinson, E S J; Roiser, J P

Depression is one of the most common but poorly understood psychiatric conditions. Although drug treatments and psychological therapies are effective in some patients, many do not achieve full remission and some patients receive no apparent benefit. Developing new improved treatments requires a better understanding of the aetiology of symptoms and evaluation of novel therapeutic targets in pre-clinical studies. Recent developments in our understanding of the basic cognitive processes that may contribute to the development of depression and its treatment offer new opportunities for both clinical and pre-clinical research. This chapter discusses the clinical evidence supporting a cognitive neuropsychological model of depression and antidepressant efficacy, and how this information may be usefully translated to pre-clinical investigation. Studies using neuropsychological tests in depressed patients and at risk populations have revealed basic negative emotional biases and disrupted reward and punishment processing, which may also impact on non-affective cognition. These affective biases are sensitive to antidepressant treatments with early onset effects observed, suggesting an important role in recovery. This clinical work into affective biases has also facilitated back-translation to animals and the development of assays to study affective biases in rodents. These animal studies suggest that, similar to humans, rodents in putative negative affective states exhibit negative affective biases on decision-making and memory tasks. Antidepressant treatments also induce positive biases in these rodent tasks, supporting the translational validity of this approach. Although still in the early stages of development and validation, affective biases in depression have the potential to offer new insights into the clinical condition, as well as facilitating the development of more translational approaches for pre-clinical studies.

[Application of an Adaptive Inertia Weight Particle Swarm Algorithm in the Magnetic Resonance Bias Field Correction].

PubMed

Wang, Chang; Qin, Xin; Liu, Yan; Zhang, Wenchao

2016-06-01

An adaptive inertia weight particle swarm algorithm is proposed in this study to solve the local optimal problem with the method of traditional particle swarm optimization in the process of estimating magnetic resonance(MR)image bias field.An indicator measuring the degree of premature convergence was designed for the defect of traditional particle swarm optimization algorithm.The inertia weight was adjusted adaptively based on this indicator to ensure particle swarm to be optimized globally and to avoid it from falling into local optimum.The Legendre polynomial was used to fit bias field,the polynomial parameters were optimized globally,and finally the bias field was estimated and corrected.Compared to those with the improved entropy minimum algorithm,the entropy of corrected image was smaller and the estimated bias field was more accurate in this study.Then the corrected image was segmented and the segmentation accuracy obtained in this research was 10% higher than that with improved entropy minimum algorithm.This algorithm can be applied to the correction of MR image bias field.

Neighborhood Disadvantage, Stressful Life Events, and Adjustment among Mexican American Early Adolescents

ERIC Educational Resources Information Center

Roosa, Mark W.; Burrell, Ginger L.; Nair, Rajni L.; Coxe, Stefany; Tein, Jenn-Yun; Knight, George P.

2010-01-01

This study examined a stress process model in which stressful life events and association with delinquent peers mediated the relationship of neighborhood disadvantage to Mexican American early adolescents' mental health. The authors also proposed that child gender, child generation, and neighborhood informal social control would moderate the…

Do the early attentional components of ERPs reflect attentional bias in depression? It depends on the stimulus presentation time.

PubMed

Mingtian, Zhong; Xiongzhao, Zhu; Jinyao, Yi; Shuqiao, Yao; Atchley, Ruth Ann

2011-07-01

The study aimed to utilize behavioral and electrophysiological data to investigate whether depressed patients show an attentional bias in a task that allows for explicit insight into the time course of selective attention processes. Event-related potentials (ERPs) were collected from 24 patients with major depressive disorder (MDD) and 25 never-depressed individuals (ND) during a dot-probe task, using pairs of affectively valenced pictures as cues. Cue presentation time was either 100 ms or 500 ms. When the cue presentation time was 500 ms, bias scores for positive-neutral picture pairs (POS-NEU) were negative for the MDD group and positive for the ND group which means ND individuals were able to successfully select positive information. These behavioral effects were supported by ERP results. In the ND group, at the right parietal-occipital region, P1 amplitude during valid POS-NEU pairs was significantly larger than that during invalid POS-NEU pairs; this pattern did not appear in the MDD group. These results suggest that MDD patients are characterized by a deficit in protection bias, meaning that these participants cannot avoid attending to negative information in their environment, but only when negative stimuli are presented for a sufficient period of time. Attentional bias is modulated by duration of emotional pictures presentation in depression. Copyright © 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Affective bias as a rational response to the statistics of rewards and punishments.

PubMed

Pulcu, Erdem; Browning, Michael

2017-10-04

Affective bias, the tendency to differentially prioritise the processing of negative relative to positive events, is commonly observed in clinical and non-clinical populations. However, why such biases develop is not known. Using a computational framework, we investigated whether affective biases may reflect individuals' estimates of the information content of negative relative to positive events. During a reinforcement learning task, the information content of positive and negative outcomes was manipulated independently by varying the volatility of their occurrence. Human participants altered the learning rates used for the outcomes selectively, preferentially learning from the most informative. This behaviour was associated with activity of the central norepinephrine system, estimated using pupilometry, for loss outcomes. Humans maintain independent estimates of the information content of distinct positive and negative outcomes which may bias their processing of affective events. Normalising affective biases using computationally inspired interventions may represent a novel approach to treatment development.

Affective bias as a rational response to the statistics of rewards and punishments

PubMed Central

Pulcu, Erdem

2017-01-01

Affective bias, the tendency to differentially prioritise the processing of negative relative to positive events, is commonly observed in clinical and non-clinical populations. However, why such biases develop is not known. Using a computational framework, we investigated whether affective biases may reflect individuals’ estimates of the information content of negative relative to positive events. During a reinforcement learning task, the information content of positive and negative outcomes was manipulated independently by varying the volatility of their occurrence. Human participants altered the learning rates used for the outcomes selectively, preferentially learning from the most informative. This behaviour was associated with activity of the central norepinephrine system, estimated using pupilometry, for loss outcomes. Humans maintain independent estimates of the information content of distinct positive and negative outcomes which may bias their processing of affective events. Normalising affective biases using computationally inspired interventions may represent a novel approach to treatment development. PMID:28976304

Examining Androcentric Bias in a Scholarly Journal.

ERIC Educational Resources Information Center

Epp, Juanita Ross; And Others

In the early 1980s, Shakeshaft and Hanson reviewed the 10 volumes of "Educational Administration Quarterly" (EAQ) that were published during the 1970s for evidence of androcentric bias. Androcentric bias is said to occur when the theory and research is informed by the male perspective. The underlying assumption is that the experience of…

Sheet-gravel evidence for a late Holocene tsunami run-up on beach dunes, Great Barrier Island, New Zealand

NASA Astrophysics Data System (ADS)

Nichol, Scott L.; Lian, Olav B.; Carter, Charles H.

2003-01-01

A semi-continuous sheet of granule to cobble-size clasts forms a distinctive deposit on sand dunes located on a coastal barrier in Whangapoua Bay, Great Barrier Island, New Zealand. The gravel sheet extends from the toe of the foredune to 14.3 m above mean sea level and 200 m landward from the beach. Clasts are rounded to sub-rounded and comprise lithologies consistent with local bedrock. Terrestrial sources for the gravel are considered highly unlikely due to the isolation of the dunes from hillslopes and streams. The only source for the clasts is the nearshore to inner shelf of Whangapoua Bay, where gravel sediments have been previously documented. The mechanism for transport of the gravel is unlikely to be storm surge due to the elevation of the deposit; maximum-recorded storm surge on this coast is 0.8 m above mean high water spring tide. Aeolian processes are also discounted due to the size of clasts and the elevation at which they occur. Tsunami is therefore considered the most probable mechanism for gravel transport. Minimum run-up height of the tsunami was 14.3 m, based on maximum elevation of gravel deposits. Optical ages on dune sands beneath and covering the gravel allow age bracketing to 0-4.7 ka. Within this time frame, numerous documented regional seismic and volcanic events could have generated the tsunami, notably submarine volcanism along the southern Kermadec arc to the east-southeast of Great Barrier Island where large magnitude events are documented for the late Holocene. Radiocarbon ages on shell from Maori middens that appear to have been reworked by tsunami run-up constrain the age of this event to post ca. 1400 AD. Regardless of the precise age of this event, the well-preserved nature of the Whangapoua gravel deposit provides for an improved understanding of the high degree of spatial variability in tsunami run-up.

Electrophysiological evidence of the time course of attentional bias in non-patients reporting symptoms of depression with and without co-occurring anxiety

PubMed Central

Sass, Sarah M.; Heller, Wendy; Fisher, Joscelyn E.; Silton, Rebecca L.; Stewart, Jennifer L.; Crocker, Laura D.; Edgar, J. Christopher; Mimnaugh, Katherine J.; Miller, Gregory A.

2014-01-01

Anxiety is characterized by attentional biases to threat, but findings are inconsistent for depression. To address this inconsistency, the present study systematically assessed the role of co-occurring anxiety in attentional bias in depression. In addition, the role of emotional valence, arousal, and gender was explored. Ninety-two non-patients completed the Penn State Worry Questionnaire (Meyer et al., 1990; Molina and Borkovec, 1994) and portions of the Mood and Anxiety Symptom Questionnaire (Watson et al., 1995a,1995b). Individuals reporting high levels of depression and low levels of anxiety (depression only), high levels of depression and anxiety (combined), or low levels of both (control) completed an emotion-word Stroop task during event-related brain potential recording. Pleasant and unpleasant words were matched on emotional arousal level. An attentional bias was not evident in the depression-only group. Women in the combined group had larger N200 amplitude for pleasant than unpleasant stimuli, and the combined group as a whole had larger right-lateralized P300 amplitude for pleasant than unpleasant stimuli, consistent with an early and later attentional bias that is specific to unpleasant valence in the combined group. Men in the control group had larger N200 amplitude for pleasant than unpleasant stimuli, consistent with an early attentional bias that is specific to pleasant valence. The present study indicates that the nature and time course of attention prompted by emotional valence and not arousal differentiates depression with and without anxiety, with some evidence of gender moderating early effects. Overall, results suggest that co-occurring anxiety is more important than previously acknowledged in demonstrating evidence of attentional biases in depression. PMID:24782804

The Effects of Backwards Running Training on Forward Running Economy in Trained Males.

PubMed

Ordway, Jason D; Laubach, Lloyd L; Vanderburgh, Paul M; Jackson, Kurt J

2016-03-01

Backwards running (BR) results in greater cardiopulmonary response and muscle activity compared with forward running (FR). BR has traditionally been used in rehabilitation for disorders such as stroke and lower leg extremity injuries, as well as in short bursts during various athletic events. The aim of this study was to measure the effects of sustained backwards running training on forward running economy in trained male athletes. Eight highly trained, male runners (26.13 ± 6.11 years, 174.7 ± 6.4 cm, 68.4 ± 9.24 kg, 8.61 ± 3.21% body fat, 71.40 ± 7.31 ml·kg(-1)·min(-1)) trained with BR while harnessed on a treadmill at 161 m·min(-1) for 5 weeks following a 5-week BR run-in period at a lower speed (134 m·min(-1)). Subjects were tested at baseline, postfamiliarized, and post-BR training for body composition, a ramped VO2max test, and an economy test designed for trained male runners. Subjects improved forward running economy by 2.54% (1.19 ± 1.26 ml·kg(-1)·min(-1), p = 0.032) at 215 m·min(-1). VO2max, body mass, lean mass, fat mass, and % body fat did not change (p > 0.05). Five weeks of BR training improved FR economy in healthy, trained male runners without altering VO2max or body composition. The improvements observed in this study could be a beneficial form of training to an already economical population to improve running economy.

Early Life Conditions, Adverse Life Events, and Chewing Ability at Middle and Later Adulthood

PubMed Central

Watt, Richard G.; Tsakos, Georgios

2014-01-01

Objectives. We sought to determine the extent to which early life conditions and adverse life events impact chewing ability in middle and later adulthood. Methods. Secondary analyses were conducted based on data from waves 2 and 3 of the Survey of Health, Ageing, and Retirement in Europe (SHARE), collected in the years 2006 to 2009 and encompassing information on current chewing ability and the life history of persons aged 50 years or older from 13 European countries. Logistic regression models were estimated with sequential inclusion of explanatory variables representing living conditions in childhood and adverse life events. Results. After controlling for current determinants of chewing ability at age 50 years or older, certain childhood and later life course socioeconomic, behavioral, and cognitive factors became evident as correlates of chewing ability at age 50 years or older. Specifically, childhood financial hardship was identified as an early life predictor of chewing ability at age 50 years or older (odds ratio = 1.58; 95% confidence interval = 1.22, 2.06). Conclusions. Findings suggest a potential enduring impact of early life conditions and adverse life events on oral health in middle and later adulthood and are relevant for public health decision-makers who design strategies for optimal oral health. PMID:24625140

Emotional sensitization highlights the attentional bias in blood-injection-injury phobics: an ERP study.

PubMed

Sarlo, Michela; Buodo, Giulia; Devigili, Andrea; Munafò, Marianna; Palomba, Daniela

2011-02-18

The presence of an attentional bias towards disorder-related stimuli has not been consistently demonstrated in blood phobics. The present study was aimed at investigating whether or not an attentional bias, as measured by event-related potentials (ERPs), could be highlighted in blood phobics by inducing cognitive-emotional sensitization through the repetitive presentation of different disorder-related pictures. The mean amplitudes of the N100, P200, P300 and late positive potentials to picture onset were assessed along with subjective ratings of valence and arousal in 13 blood phobics and 12 healthy controls. Blood phobics, but not controls, showed a linear increase of subjective arousal over time, suggesting that cognitive-emotional sensitization did occur. The analysis of cortical responses showed larger N100 and smaller late positive potentials in phobics than in controls in response to mutilations. These findings suggest that cognitive-emotional sensitization induced an attentional bias in blood phobics during picture viewing, involving early selective encoding and late cognitive avoidance of disorder-related stimuli depicting mutilations. © 2010 Elsevier Ireland Ltd. All rights reserved.

Environmental change during the Late Berriasian - Early Valanginian: a prelude to the late Early Valanginian carbon-isotope event?

NASA Astrophysics Data System (ADS)

Morales, Chloé; Schnyder, Johann; Spangenberg, Jorge; Adatte, Thierry; Westermann, Stephane; Föllmi, Karl

2010-05-01

The Valanginian period is well known for a positive excursion in marine and terrestrial δ13C records, which has been interpreted as the consequence of a major perturbation in the global carbon cycle (Lini et al., 1992; Erba et al., 2004). In contrast to the positive δ13C excursions of the Early Aptian and latest Cenomanian, marine organic-rich sediments have only been recognized from a few localities (van de Schootbrugge et al., 2003; Reboulet et al., 2003; Gröcke et al., 2005; Westermann et al., in press). The δ13C excursion began in the late Early Valanginian (campylotoxus ammonite zone) and gradually ended during the Late Valanginian. It is associated with a phase of widespread carbonate-platform drowning on the shelf (Föllmi et al., 1994) and a decline in calcareous nannofossils in the pelagic realm (Erba et al., 2004). As a triggering mechanism, numerous authors invoke the formation of the Parañà-Etendeka flood basalt. The correlation of this episode with the Valanginian δ13C event depends, however, on the absolute ages attributed to the Valanginian stage. The recent geological timescale by Ogg et al. (2008) shows that the major eruptional phase occurred during the Late Valanginian. This may imply that the late Early Valanginian δ13C event resulted from a combination of different factors. Important paleoenvironmental change occurred already in the latest Berriasian and earliest Valanginian, prior to the positive δ13C excursion. An increase in nutrient input near the onset of the δ13C excursion (campylotoxus ammonite zone), which may be considered as a trigger of the carbon cycle perturbation, has been identified in different studies, (Hennig, 2003; Duchamp-Alphonse et al., 2007; Bornemann & Mutterlose, 2008). Heterozoan faunal associations became dominant since the Early Valanginian on the northern Tethyan Helvetic platform and may indicate the beginning of sea-water eutrophication (Föllmi et al., 2007). Clay assemblages in the Tethys and Western

A Neutral Network based Early Eathquake Warning model in California region

NASA Astrophysics Data System (ADS)

Xiao, H.; MacAyeal, D. R.

2016-12-01

Early Earthquake Warning systems could reduce loss of lives and other economic impact resulted from natural disaster or man-made calamity. Current systems could be further enhanced by neutral network method. A 3 layer neural network model combined with onsite method was deployed in this paper to improve the recognition time and detection time for large scale earthquakes.The 3 layer neutral network early earthquake warning model adopted the vector feature design for sample events happened within 150 km radius of the epicenters. Dataset used in this paper contained both destructive events and small scale events. All the data was extracted from IRIS database to properly train the model. In the training process, backpropagation algorithm was used to adjust the weight matrices and bias matrices during each iteration. The information in all three channels of the seismometers served as the source in this model. Through designed tests, it was indicated that this model could identify approximately 90 percent of the events' scale correctly. And the early detection could provide informative evidence for public authorities to make further decisions. This indicated that neutral network model could have the potential to strengthen current early warning system, since the onsite method may greatly reduce the responding time and save more lives in such disasters.

The onset of childhood amnesia in childhood: A prospective investigation of the course and determinants of forgetting of early-life events

PubMed Central

Bauer, Patricia J.; Larkina, Marina

2013-01-01

The present research was an examination of the onset of childhood amnesia and how it relates to maternal narrative style, an important determinant of autobiographical memory development. Children and their mothers discussed unique events when the children were 3 years of age. Different subgroups of children were tested for recall of the events at ages 5, 6, 7, 8, and 9 years. At the later session, they were interviewed by an experimenter about the events discussed 2 to 6 years previously with their mothers (early-life events). Children ages 5, 6, and 7 remembered 60% or more of the early-life events. In contrast, children ages 8 and 9 years remembered fewer than 40% of the early-life events. Overall maternal narrative style predicted children's contributions to mother-child conversations at age 3 years; it did not have cross-lagged relations to memory for early-life events at ages 5 to 9 years. Maternal deflections of the conversational turn to the child predicted the amount of information children later reported about the early-life events. The findings have implications for our understanding of the onset of childhood amnesia and the achievement of an adult-like distribution of memories in the school years. They highlight the importance of forgetting processes in explanations of the amnesia. PMID:24236647

Comparison of bias analysis strategies applied to a large data set.

PubMed

Lash, Timothy L; Abrams, Barbara; Bodnar, Lisa M

2014-07-01

Epidemiologic data sets continue to grow larger. Probabilistic-bias analyses, which simulate hundreds of thousands of replications of the original data set, may challenge desktop computational resources. We implemented a probabilistic-bias analysis to evaluate the direction, magnitude, and uncertainty of the bias arising from misclassification of prepregnancy body mass index when studying its association with early preterm birth in a cohort of 773,625 singleton births. We compared 3 bias analysis strategies: (1) using the full cohort, (2) using a case-cohort design, and (3) weighting records by their frequency in the full cohort. Underweight and overweight mothers were more likely to deliver early preterm. A validation substudy demonstrated misclassification of prepregnancy body mass index derived from birth certificates. Probabilistic-bias analyses suggested that the association between underweight and early preterm birth was overestimated by the conventional approach, whereas the associations between overweight categories and early preterm birth were underestimated. The 3 bias analyses yielded equivalent results and challenged our typical desktop computing environment. Analyses applied to the full cohort, case cohort, and weighted full cohort required 7.75 days and 4 terabytes, 15.8 hours and 287 gigabytes, and 8.5 hours and 202 gigabytes, respectively. Large epidemiologic data sets often include variables that are imperfectly measured, often because data were collected for other purposes. Probabilistic-bias analysis allows quantification of errors but may be difficult in a desktop computing environment. Solutions that allow these analyses in this environment can be achieved without new hardware and within reasonable computational time frames.

Simulation of uphill/downhill running on a level treadmill using additional horizontal force.

PubMed

Gimenez, Philippe; Arnal, Pierrick J; Samozino, Pierre; Millet, Guillaume Y; Morin, Jean-Benoit

2014-07-18

Tilting treadmills allow a convenient study of biomechanics during uphill/downhill running, but they are not commonly available and there is even fewer tilting force-measuring treadmill. The aim of the present study was to compare uphill/downhill running on a treadmill (inclination of ± 8%) with running on a level treadmill using additional backward or forward pulling forces to simulate the effect of gravity. This comparison specifically focused on the energy cost of running, stride frequency (SF), electromyographic activity (EMG), leg and foot angles at foot strike, and ground impact shock. The main results are that SF, impact shock, and leg and foot angle parameters determined were very similar and significantly correlated between the two methods, the intercept and slope of the linear regression not differing significantly from zero and unity, respectively. The correlation of oxygen uptake (V̇O2) data between both methods was not significant during uphill running (r=0.42; P>0.05). V̇O2 data were correlated during downhill running (r=0.74; P<0.01) but there was a significant difference between the methods (bias=-2.51 ± 1.94 ml min(-1) kg(-1)). Linear regressions for EMG of vastus lateralis, biceps femoris, gastrocnemius lateralis, soleus and tibialis anterior were not different from the identity line but the systematic bias was elevated for this parameter. In conclusion, this method seems appropriate for the study of SF, leg and foot angle, impact shock parameters but is less applicable for physiological variables (EMG and energy cost) during uphill/downhill running when using a tilting force-measuring treadmill is not possible. Copyright © 2014 Elsevier Ltd. All rights reserved.

Divergence and codon usage bias of Betanodavirus, a neurotropic pathogen in fish.

PubMed

He, Mei; Teng, Chun-Bo

2015-02-01

Betanodavirus is a small bipartite RNA virus of global economical significance that can cause severe neurological disorders to an increasing number of marine fish species. Herein, to further the understanding of the evolution of betanodavirus, Bayesian coalescent analyses were conducted to the time-stamped entire coding sequences of their RNA polymerase and coat protein genes. Similar moderate nucleotide substitution rates were then estimated for the two genes. According to age calculations, the divergence of the two genes into the four genotypes initiated nearly simultaneously at ∼700 years ago, despite the different scenarios, whereas the seven analyzed chimeric isolates might be the outcomes of a single genetic reassortment event taking place in the early 1980s in Southern Europe. Furthermore, codon usage bias analyses indicated that each gene had influences in addition to mutational bias and codon choice of betanodavirus was not completely complied with that of fish host. Copyright © 2014 Elsevier Inc. All rights reserved.

The role of guessing and boundaries on date estimation biases.

PubMed

Lee, Peter James; Brown, Norman R

2004-08-01

This study investigates the causes of event-dating biases. Two hundred participants provided knowledge ratings and date estimates for 64 news events. Four independent groups dated the same events under different boundary constraints. Analysis across all responses showed that forward telescoping decreased with boundary age, concurring with the boundary-effects model. With guesses removed from the data set, backward telescoping was greatly reduced, but forward telescoping was unaffected by boundaries. This dissociation indicates that multiple factors (e.g., guessing and reconstructive strategies) are responsible for different dating biases and argue against a boundary explanation of forward telescoping.

CCP MRAP Run

NASA Image and Video Library

2018-04-20

An MRAP armored vehicle goes through a training run on the Shuttle Landing Facility to support NASA's Commercial Crew Program at the agency's Kennedy Space Center in Florida. The 45,000-pound mine-resistant ambush protected vehicle, or MRAP, was originally designed for military applications. The MRAP offers a mobile bunker for astronauts and ground crews in the unlikely event they have to get away from the launch pad quickly in an emergency.

CCP MRAP Run

NASA Image and Video Library

2018-04-20

Two MRAP armored vehicles go through a training run on the Shuttle Landing Facility to support NASA's Commercial Crew Program at the agency's Kennedy Space Center in Florida. The 45,000-pound mine-resistant ambush protected vehicle, or MRAPs, were originally designed for military applications. The MRAP offers a mobile bunker for astronauts and ground crews in the unlikely event they have to get away from the launch pad quickly in an emergency.

Hints from Run 1 and prospects from Run 2 at ATLAS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernius, Catrin, E-mail: Catrin.Bernius@cern.ch

2016-06-21

The Large Hadron Collider at CERN has allowed the ATLAS experiment to collect a large amount of proton-proton collision data at 7 TeV and 8 TeV centre-of-mass energies throughout Run 1. This dataset was used to discover a Higgs boson with Standard Model-like properties at a mass of about 125 GeV. Furthermore, an impressive number of searches for deviations from the Standard Model expectations have been carried out. To date, no evidence for new physics beyond the SM has been found. However, a few hints in form of 2-3 σ deviations have been observed. After an 18-month shutdown, in whichmore » the ATLAS detector has undergone various upgrades, the LHC has again started to deliver collision data at an increased centre-of-mass energy of 13 TeV, providing a much improved sensitivity for various searches, in particular for high mass particles. Some representative hints at the LHC Run 1 are presented, a brief overview of ATLAS upgrades and prospects for SUSY searches with early Run 2 data are given.« less

How Early Events Affect Growing Brains. An Interview with Neuroscientist Pat Levitt

ERIC Educational Resources Information Center

National Scientific Council on the Developing Child, 2006

2006-01-01

Recent advances in neuroscience show clearly how experience can change brain neurochemicals, and how this in turn affects the way the brain functions. As a result, early negative events actually get built into the growing brain's neurochemistry, altering the brain's architecture. Research is continuing to investigate how children with genetic…

A shortened protocol for assessing cognitive bias in rats.

PubMed

Brydges, Nichola M; Hall, Lynsey

2017-07-15

Reliable measurement of affective state in animals is a significant goal of animal welfare. Such measurements would also improve the validity of pre-clinical mental health research which relies on animal models. However, at present, affective states in animals are inaccessible to direct measurement. In humans, changes in cognitive processing can give reliable indications of emotional state. Therefore, similar techniques are increasingly being used to gain proxy measures of affective states in animals. In particular, the 'cognitive bias' assay has gained popularity in recent years. Major disadvantages of this technique include length of time taken for animals to acquire the task (typically several weeks), negative experiences associated with task training, and issues of motivation. Here we present a shortened cognitive bias protocol using only positive reinforcers which must actively be responded to. The protocol took an average of 4days to complete, and produced similar results to previous, longer methods (minimum 30days). Specifically, rats housed in standard laboratory conditions demonstrated negative cognitive biases when presented with ambiguous stimuli, and took longer to make a decision when faced with an ambiguous stimulus. Compared to previous methods, this protocol is significantly shorter (average 4days vs. minimum 30days), utilises only positive reinforcers to avoid inducing negative affective states, and requires active responses to all cues, avoiding potential confounds of motivational state. We have successfully developed a shortened cognitive bias protocol, suitable for use with laboratory rats. Copyright © 2017 The Author(s). Published by Elsevier B.V. All rights reserved.

A Further Extension of the Tahiti-Darwin SOI, Early ENSO Events and Darwin Pressure.

NASA Astrophysics Data System (ADS)

Allan, Robert J.; Nicholls, Neville; Jones, Phil D.; Butterworth, Ian J.

1991-07-01

An extension of the Tahiti minus Darwin Southern Oscillation Index (SOI) from 1882 back to 1876 is reported following the recovery of early Darwin mean sea-level pressure data spanning the period 1865-81. As a result, we are able to compare, for the first time, the major 1877-78 and 1982-83 ENSO events on the basis of this commonly used index. Early Darwin and Jakarta data are also examined in terms of a measure of the Australian response to documented El Niño and/or ENSO events in 1866, 1868, 1871, 1873, 1874 and 1875.The SOI during the 1877-78 ENSO event has a similar temporal response to that in 1982-83, but the index is slightly weaker than in the recent event. Examination of documentary evidence confirms the severity of the drought conditions that affected the Australian continent during the 1877-78 ENSO, and shows that this response is in line with the wider Indo-Pacific impacts reported in the literature. Earlier El Niño phases in 1868 and 1873 are not resolved distinctly in either the Darwin or Jakarta pressure data. This appears to illustrate that El Niño event histories do not always indicate wider ENSO influences in the Indo-Pacific basin, particularly during weak to moderate phases.

A training image evaluation and selection method based on minimum data event distance for multiple-point geostatistics

NASA Astrophysics Data System (ADS)

Feng, Wenjie; Wu, Shenghe; Yin, Yanshu; Zhang, Jiajia; Zhang, Ke

2017-07-01

A training image (TI) can be regarded as a database of spatial structures and their low to higher order statistics used in multiple-point geostatistics (MPS) simulation. Presently, there are a number of methods to construct a series of candidate TIs (CTIs) for MPS simulation based on a modeler's subjective criteria. The spatial structures of TIs are often various, meaning that the compatibilities of different CTIs with the conditioning data are different. Therefore, evaluation and optimal selection of CTIs before MPS simulation is essential. This paper proposes a CTI evaluation and optimal selection method based on minimum data event distance (MDevD). In the proposed method, a set of MDevD properties are established through calculation of the MDevD of conditioning data events in each CTI. Then, CTIs are evaluated and ranked according to the mean value and variance of the MDevD properties. The smaller the mean value and variance of an MDevD property are, the more compatible the corresponding CTI is with the conditioning data. In addition, data events with low compatibility in the conditioning data grid can be located to help modelers select a set of complementary CTIs for MPS simulation. The MDevD property can also help to narrow the range of the distance threshold for MPS simulation. The proposed method was evaluated using three examples: a 2D categorical example, a 2D continuous example, and an actual 3D oil reservoir case study. To illustrate the method, a C++ implementation of the method is attached to the paper.

Meta-regression approximations to reduce publication selection bias.

PubMed

Stanley, T D; Doucouliagos, Hristos

2014-03-01

Publication selection bias is a serious challenge to the integrity of all empirical sciences. We derive meta-regression approximations to reduce this bias. Our approach employs Taylor polynomial approximations to the conditional mean of a truncated distribution. A quadratic approximation without a linear term, precision-effect estimate with standard error (PEESE), is shown to have the smallest bias and mean squared error in most cases and to outperform conventional meta-analysis estimators, often by a great deal. Monte Carlo simulations also demonstrate how a new hybrid estimator that conditionally combines PEESE and the Egger regression intercept can provide a practical solution to publication selection bias. PEESE is easily expanded to accommodate systematic heterogeneity along with complex and differential publication selection bias that is related to moderator variables. By providing an intuitive reason for these approximations, we can also explain why the Egger regression works so well and when it does not. These meta-regression methods are applied to several policy-relevant areas of research including antidepressant effectiveness, the value of a statistical life, the minimum wage, and nicotine replacement therapy. Copyright © 2013 John Wiley & Sons, Ltd.

When does eruption run-up begin? Multidisciplinary insight from the 1999 eruption of Shishaldin volcano

NASA Astrophysics Data System (ADS)

Rasmussen, Daniel J.; Plank, Terry A.; Roman, Diana C.; Power, John A.; Bodnar, Robert J.; Hauri, Erik H.

2018-03-01

During the run-up to eruption, volcanoes often show geophysically detectable signs of unrest. However, there are long-standing challenges in interpreting the signals and evaluating the likelihood of eruption, especially during the early stages of volcanic unrest. Considerable insight can be gained from combined geochemical and geophysical studies. Here we take such an approach to better understand the beginning of eruption run-up, viewed through the lens of the 1999 sub-Plinian basaltic eruption of Shishaldin volcano, Alaska. The eruption is of interest due to its lack of observed deformation and its apparent long run-up time (9 months), following a deep long-period earthquake swarm. We evaluate the nature and timing of recharge by examining the composition of 138 olivine macrocrysts and 53 olivine-hosted melt inclusions and through shear-wave splitting analysis of regional earthquakes. Magma mixing is recorded in three crystal populations: a dominant population of evolved olivines (Fo60-69) that are mostly reversely zoned, an intermediate population (Fo69-76) with mixed zonation, and a small population of normally zoned more primitive olivines (Fo76-80). Mixing-to-eruption timescales are obtained through modeling of Fe-Mg interdiffusion in 78 olivines. The large number of resultant timescales provides a thorough record of mixing, demonstrating at least three mixing events: a minor event ∼11 months prior to eruption, overlapping within uncertainty with the onset of deep long-period seismicity; a major event ∼50 days before eruption, coincident with a large (M5.2) shallow earthquake; and a final event about a week prior to eruption. Shear-wave splitting analysis shows a change in the orientation of the local stress field about a month after the deep long-period swarm and around the time of the M5.2 event. Earthquake depths and vapor saturation pressures of Raman-reconstructed melt inclusions indicate that the recharge magma originated from depths of at least 20

Intention Seekers: Conspiracist Ideation and Biased Attributions of Intentionality

PubMed Central

2015-01-01

Conspiracist beliefs are widespread and potentially hazardous. A growing body of research suggests that cognitive biases may play a role in endorsement of conspiracy theories. The current research examines the novel hypothesis that individuals who are biased towards inferring intentional explanations for ambiguous actions are more likely to endorse conspiracy theories, which portray events as the exclusive product of intentional agency. Study 1 replicated a previously observed relationship between conspiracist ideation and individual differences in anthropomorphisation. Studies 2 and 3 report a relationship between conspiracism and inferences of intentionality for imagined ambiguous events. Additionally, Study 3 again found conspiracist ideation to be predicted by individual differences in anthropomorphism. Contrary to expectations, however, the relationship was not mediated by the intentionality bias. The findings are discussed in terms of a domain-general intentionality bias making conspiracy theories appear particularly plausible. Alternative explanations are suggested for the association between conspiracism and anthropomorphism. PMID:25970175

Early event related fields during visually evoked pain anticipation.

PubMed

Gopalakrishnan, Raghavan; Burgess, Richard C; Plow, Ela B; Floden, Darlene P; Machado, Andre G

2016-03-01

Pain experience is not only a function of somatosensory inputs. Rather, it is strongly influenced by cognitive and affective pathways. Pain anticipatory phenomena, an important limitation to rehabilitative efforts in the chronic state, are processed by associative and limbic networks, along with primary sensory cortices. Characterization of neurophysiological correlates of pain anticipation, particularly during very early stages of neural processing is critical for development of therapeutic interventions. Here, we utilized magnetoencephalography to study early event-related fields (ERFs) in healthy subjects exposed to a 3 s visual countdown task that preceded a painful stimulus, a non-painful stimulus or no stimulus. We found that the first countdown cue, but not the last cue, evoked critical ERFs signaling anticipation, attention and alertness to the noxious stimuli. Further, we found that P2 and N2 components were significantly different in response to first-cues that signaled incoming painful stimuli when compared to non-painful or no stimuli. The findings indicate that early ERFs are relevant neural substrates of pain anticipatory phenomena and could be potentially serve as biomarkers. These measures could assist in the development of neurostimulation approaches aimed at curbing the negative effects of pain anticipation during rehabilitation. Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Effects of subcallosal cingulate deep brain stimulation on negative self-bias in patients with treatment-resistant depression.

PubMed

Hilimire, Matthew R; Mayberg, Helen S; Holtzheimer, Paul E; Broadway, James M; Parks, Nathan A; DeVylder, Jordan E; Corballis, Paul M

2015-01-01

The cognitive neuropsychological model states that antidepressant treatment alters emotional biases early in treatment, and after this initial change in emotional processing, environmental and social interactions allow for long-term/sustained changes in mood and behavior. Changes in negative self-bias after chronic subcallosal cingulate (SCC) deep brain stimulation (DBS) were investigated with the hypothesis that treatment would lead to changes in emotional biases followed by changes in symptom severity. Patients (N = 7) with treatment-resistant depression were assessed at three time points: pre-treatment; after one month stimulation; and after six months stimulation. The P1, P2, P3, and LPP (late positive potential) components of the event-related potential elicited by positive and negative trait adjectives were recorded in both a self-referential task and a general emotion recognition task. Results indicate that DBS reduced automatic attentional bias toward negative words early in treatment, as indexed by the P1 component, and controlled processing of negative words later in treatment, as indexed by the P3 component. Reduction in negative words endorsed as self-descriptive after six months DBS was associated with reduced depression severity after six months DBS. Change in emotional processing may be restricted to the self-referential task. Together, these results suggest that the cognitive neuropsychological model, developed to explain the time-course of monoamine antidepressant treatment, may also be used as a framework to interpret the antidepressant effects of SCC DBS. Copyright © 2015 Elsevier Inc. All rights reserved.

Development and validation of the European Cluster Assimilation Techniques run libraries

NASA Astrophysics Data System (ADS)

Facskó, G.; Gordeev, E.; Palmroth, M.; Honkonen, I.; Janhunen, P.; Sergeev, V.; Kauristie, K.; Milan, S.

2012-04-01

The European Commission funded the European Cluster Assimilation Techniques (ECLAT) project as a collaboration of five leader European universities and research institutes. A main contribution of the Finnish Meteorological Institute (FMI) is to provide a wide range global MHD runs with the Grand Unified Magnetosphere Ionosphere Coupling simulation (GUMICS). The runs are divided in two categories: Synthetic runs investigating the extent of solar wind drivers that can influence magnetospheric dynamics, as well as dynamic runs using measured solar wind data as input. Here we consider the first set of runs with synthetic solar wind input. The solar wind density, velocity and the interplanetary magnetic field had different magnitudes and orientations; furthermore two F10.7 flux values were selected for solar radiation minimum and maximum values. The solar wind parameter values were constant such that a constant stable solution was archived. All configurations were run several times with three different (-15°, 0°, +15°) tilt angles in the GSE X-Z plane. The result of the 192 simulations named so called "synthetic run library" were visualized and uploaded to the homepage of the FMI after validation. Here we present details of these runs.

Commercial influence and learner-perceived bias in continuing medical education.

PubMed

Steinman, Michael A; Boscardin, Christy K; Aguayo, Leslie; Baron, Robert B

2010-01-01

To directly examine the relationship between commercial support of continuing medical education (CME) and perceived bias in the content of these activities. Cross-sectional study of 213 accredited live educational programs organized by a university provider of CME from 2005 to 2007. A standard question from course evaluations was used to determine the degree to which attendees believed commercial bias was present. Binomial regression models were used to determine the association between course features that may introduce commercial bias and the extent of perceived bias at those CME activities. Mean response rate for attendee evaluations was 56% (SD 15%). Commercial support covered 20%-49% of costs for 45 (21%) educational activities, and > or = 50% of costs for 46 activities (22%). Few course participants perceived commercial bias, with a median of 97% (interquartile range 95%-99%) of respondents stating that the activity they attended was free of commercial bias. There was no association between extent of commercial support and the degree of perceived bias in CME activities. Similarly, perceived bias did not vary for 11 of 12 event characteristics evaluated as potential sources of commercial bias, or by score on a risk index designed to prospectively assess risk of commercial bias. Rates of perceived bias were low for the vast majority of CME activities in the sample and did not differ by the degree of industry support or other event characteristics. Further study is needed to determine whether commercial influence persisted in more subtle forms that were difficult for participants to detect.

Biasing spatial attention with semantic information: an event coding approach.

PubMed

Amer, Tarek; Gozli, Davood G; Pratt, Jay

2017-04-21

We investigated the influence of conceptual processing on visual attention from the standpoint of Theory of Event Coding (TEC). The theory makes two predictions: first, an important factor in determining the influence of event 1 on processing event 2 is whether features of event 1 are bound into a unified representation (i.e., selection or retrieval of event 1). Second, whether processing the two events facilitates or interferes with each other should depend on the extent to which their constituent features overlap. In two experiments, participants performed a visual-attention cueing task, in which the visual target (event 2) was preceded by a relevant or irrelevant explicit (e.g., "UP") or implicit (e.g., "HAPPY") spatial-conceptual cue (event 1). Consistent with TEC, we found relevant explicit cues (which featurally overlap to a greater extent with the target) and implicit cues (which featurally overlap to a lesser extent), respectively, facilitated and interfered with target processing at compatible locations. Irrelevant explicit and implicit cues, on the other hand, both facilitated target processing, presumably because they were less likely selected or retrieved as an integrated and unified event file. We argue that such effects, often described as "attentional cueing", are better accounted for within the event coding framework.

Energy system contribution to 400-metre and 800-metre track running.

PubMed

Duffield, Rob; Dawson, Brian; Goodman, Carmel

2005-03-01

As a wide range of values has been reported for the relative energetics of 400-m and 800-m track running events, this study aimed to quantify the respective aerobic and anaerobic energy contributions to these events during track running. Sixteen trained 400-m (11 males, 5 females) and 11 trained 800-m (9 males, 2 females) athletes participated in this study. The participants performed (on separate days) a laboratory graded exercsie test and multiple race time-trials. The relative energy system contribution was calculated by multiple methods based upon measures of race VO2, accumulated oxygen deficit (AOD), blood lactate and estimated phosphocreatine degradation (lactate/PCr). The aerobic/anaerobic energy system contribution (AOD method) to the 400-m event was calculated as 41/59% (male) and 45/55% (female). For the 800-m event, an increased aerobic involvement was noted with a 60/40% (male) and 70/30% (female) respective contribution. Significant (P < 0.05) negative correlations were noted between race performance and anaerobic energy system involvement (lactate/PCr) for the male 800-m and female 400-m events (r = - 0.77 and - 0.87 respectively). These track running data compare well with previous estimates of the relative energy system contributions to the 400-m and 800-m events. Additionally, the relative importance and speed of interaction of the respective metabolic pathways has implications to training for these events.

Dose and Effect Thresholds for Early Key Events in a Mode of ...

EPA Pesticide Factsheets

ABSTRACT Strategies for predicting adverse health outcomes of environmental chemicals are centered on early key events in toxicity pathways. However, quantitative relationships between early molecular changes in a given pathway and later health effects are often poorly defined. The goal of this study was to evaluate short-term key event indicators using qualitative and quantitative methods in an established pathway of mouse liver tumorigenesis mediated by peroxisome proliferator-activated receptor-alpha (PPARα). Male B6C3F1 mice were exposed for 7 days to di(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), and n-butyl benzyl phthalate (BBP), which vary in PPARα activity and liver tumorigenicity. Each phthalate increased expression of select PPARα target genes at 7 days, while only DEHP significantly increased liver cell proliferation labeling index (LI). Transcriptional benchmark dose (BMDT) estimates for dose-related genomic markers stratified phthalates according to hypothetical tumorigenic potencies, unlike BMDs for non-genomic endpoints (liver weights or proliferation). The 7-day BMDT values for Acot1 as a surrogate measure for PPARα activation were 29, 370, and 676 mg/kg-d for DEHP, DNOP, and BBP, respectively, distinguishing DEHP (liver tumor BMD of 35 mg/kg-d) from non-tumorigenic DNOP and BBP. Effect thresholds were generated using linear regression of DEHP effects at 7 days and 2-year tumor incidence values to anchor early response molec

Decision making biases in the communication of earthquake risk

NASA Astrophysics Data System (ADS)

Welsh, M. B.; Steacy, S.; Begg, S. H.; Navarro, D. J.

2015-12-01

L'Aquila, with 6 scientists convicted of manslaughter, shocked the scientific community, leading to urgent re-appraisal of communication methods for low-probability, high-impact events. Before the trial, a commission investigating the earthquake recommended risk assessment be formalised via operational earthquake forecasts and that social scientists be enlisted to assist in developing communication strategies. Psychological research has identified numerous decision biases relevant to this, including hindsight bias, where people (after the fact) overestimate an event's predictability. This affects experts as well as naïve participants as it relates to their ability to construct a plausible causal story rather than the likelihood of the event. Another problem is availability, which causes overestimation of the likelihood of observed rare events due to their greater noteworthiness. This, however, is complicated by the 'description-experience' gap, whereby people underestimate probabilities for events they have not experienced. That is, people who have experienced strong earthquakes judge them more likely while those who have not judge them less likely - relative to actual probabilities. Finally, format changes alter people's decisions. That is people treat '1 in 10,000' as different from 0.01% despite their mathematical equivalence. Such effects fall under the broad term framing, which describes how different framings of the same event alter decisions. In particular, people's attitude to risk depends significantly on how scenarios are described. We examine the effect of biases on the communication of change in risk. South Australian participants gave responses to scenarios describing familiar (bushfire) or unfamiliar (earthquake) risks. While bushfires are rare in specific locations, significant fire events occur each year and are extensively covered. By comparison, our study location (Adelaide) last had a M5 quake in 1954. Preliminary results suggest the description

The Long and Short of It: Closing the Description-Experience "Gap" by Taking the Long-Run View

ERIC Educational Resources Information Center

Camilleri, Adrian R.; Newell, Ben R.

2013-01-01

Previous research has shown that many choice biases are attenuated when short-run decisions are reframed to the long run. However, this literature has been limited to description-based choice tasks in which possible outcomes and their probabilities are explicitly specified. A recent literature has emerged showing that many core results found using…

Using Physiological Principles to Explain Sex Differences in Running and Swimming Performances

ERIC Educational Resources Information Center

Dollman, Jim

2005-01-01

Demonstrated sex differences in physical characteristics are used to know the performance differences between first-placed males and females from latest world championships in swimming and running. The performance comparisons (PCs) reveal smaller differences between males and females in running sprint events than longer distance running and the…

Smoothed Biasing Forces Yield Unbiased Free Energies with the Extended-System Adaptive Biasing Force Method

PubMed Central

2016-01-01

We report a theoretical description and numerical tests of the extended-system adaptive biasing force method (eABF), together with an unbiased estimator of the free energy surface from eABF dynamics. Whereas the original ABF approach uses its running estimate of the free energy gradient as the adaptive biasing force, eABF is built on the idea that the exact free energy gradient is not necessary for efficient exploration, and that it is still possible to recover the exact free energy separately with an appropriate estimator. eABF does not directly bias the collective coordinates of interest, but rather fictitious variables that are harmonically coupled to them; therefore is does not require second derivative estimates, making it easily applicable to a wider range of problems than ABF. Furthermore, the extended variables present a smoother, coarse-grain-like sampling problem on a mollified free energy surface, leading to faster exploration and convergence. We also introduce CZAR, a simple, unbiased free energy estimator from eABF trajectories. eABF/CZAR converges to the physical free energy surface faster than standard ABF for a wide range of parameters. PMID:27959559

Running SINDA '85/FLUINT interactive on the VAX

NASA Technical Reports Server (NTRS)

Simmonds, Boris

1992-01-01

Computer software as engineering tools are typically run in three modes: Batch, Demand, and Interactive. The first two are the most popular in the SINDA world. The third one is not so popular, due probably to the users inaccessibility to the command procedure files for running SINDA '85, or lack of familiarity with the SINDA '85 execution processes (pre-processor, processor, compilation, linking, execution and all of the file assignment, creation, deletions and de-assignments). Interactive is the mode that makes thermal analysis with SINDA '85 a real-time design tool. This paper explains a command procedure sufficient (the minimum modifications required in an existing demand command procedure) to run SINDA '85 on the VAX in an interactive mode. To exercise the procedure a sample problem is presented exemplifying the mode, plus additional programming capabilities available in SINDA '85. Following the same guidelines the process can be extended to other SINDA '85 residence computer platforms.

The Effects of Long Distance Running on Preadolescent Children.

ERIC Educational Resources Information Center

Covington, N. Kay

This study investigated the effects of selected physiological variables on preadolescent male and female long distance runners. The trained group was comprised of 20 children between the ages of 8 and 10 who had been running a minimum of 20 miles per week for two months or longer. The control group was made up of 20 children of the same ages who…

Constraints on early events in Martian history as derived from the cratering record

NASA Technical Reports Server (NTRS)

Barlow, Nadine G.

1990-01-01

Constrains on early events in Martian history are derived using the planet's cratering record. Variations in the shapes of the crater size-frequency distribution curves are interpreted as indicative of the size-frequency distribution of the production populations, thus providing information about the age of the unit relative to the end of the heavy bombardment period. Results from the analysis of craters superposed on heavily cratered units across the Martian surface provide constraints on the hemispheric dichotomy and the early erosional conditions on Mars.

Negative affective spillover from daily events predicts early response to cognitive therapy for depression.

PubMed

Cohen, Lawrence H; Gunthert, Kathleen C; Butler, Andrew C; Parrish, Brendt P; Wenze, Susan J; Beck, Judith S

2008-12-01

This study evaluated the predictive role of depressed outpatients' (N = 62) affective reactivity to daily stressors in their rates of improvement in cognitive therapy (CT). For 1 week before treatment, patients completed nightly electronic diaries that assessed daily stressors and negative affect (NA). The authors used multilevel modeling to compute each patient's within-day relationship between daily stressors and daily NA (within-day reactivity), as well as the relationship between daily stressors and next-day NA (next-day reactivity; affective spillover). In growth model analyses, the authors evaluated the predictive role of patients' NA reactivity in their early (Sessions 1-4) and late (Sessions 5-12) response to CT. Within-day NA reactivity did not predict early or late response to CT. However, next-day reactivity predicted early response to CT, such that patients who had greater NA spillover in response to negative events had a slower rate of symptom change during the first 4 sessions. Affective spillover did not influence later response to CT. The findings suggest that depressed patients who have difficulty bouncing back the next day from their NA reactions to a relative increase in daily negative events will respond less quickly to the early sessions of CT.

Preventing running injuries. Practical approach for family doctors.

PubMed Central

Johnston, C. A. M.; Taunton, J. E.; Lloyd-Smith, D. R.; McKenzie, D. C.

2003-01-01

OBJECTIVE: To present a practical approach for preventing running injuries. QUALITY OF EVIDENCE: Much of the research on running injuries is in the form of expert opinion and comparison trials. Recent systematic reviews have summarized research in orthotics, stretching before running, and interventions to prevent soft tissue injuries. MAIN MESSAGE: The most common factors implicated in running injuries are errors in training methods, inappropriate training surfaces and running shoes, malalignment of the leg, and muscle weakness and inflexibility. Runners can reduce risk of injury by using established training programs that gradually increase distance or time of running and provide appropriate rest. Orthoses and heel lifts can correct malalignments of the leg. Running shoes appropriate for runners' foot types should be selected. Lower-extremity strength and flexibility programs should be added to training. Select appropriate surfaces for training and introduce changes gradually. CONCLUSION: Prevention addresses factors proven to cause running injuries. Unfortunately, injury is often the first sign of fault in running programs, so patients should be taught to recognize early symptoms of injury. PMID:14526862

The early Toarcian anoxic event: what the beginning and the end of the story are?

NASA Astrophysics Data System (ADS)

Mattioli, Emanuela; Plancq, Julien; Raucsik, Béla

2010-05-01

The early Toarcian anoxic event: what the beginning and the end of the story are? E. Mattioli (1), J. Plancq (1), and B. Rauksik (2) (1) UMR 5125 PEPS, CNRS, France; Université Lyon 1, Campus de la DOUA, Bâtiment Géode, 69622 Villeurbanne Cedex, France (emanuela.mattioli@univ-lyon1.fr) (2) Department of Earth and Environmental Sciences, University of Pannonia, Veszprém, Hungary The early Toarcian anoxic event (T-OAE) and the associated biotic crisis have received much attention in the last decade. However, the events forewarning the crisis as well as its aftermath are still poorly known. The T-OAE coincides with a prominent carbon isotope negative excursion (T-CIE) that is preceded by an excursion of similar intensity at the Pliensbachian-Toarcian boundary (Hesselbo et al., 2007). The onset of T-CIE occurred some 700 kyr later than the end of the Boundary-CIE (Suan et al., 2008a). This succession of events demonstrates that the T-OAE was a complex suite of environmental perturbations. In this work, we focused on calcareous nannofossil assemblages occurring in the Peniche section (Portugal) during the Boundary-CIE with the aim to understand if calcifying plankton reacted in a similar/different way to the two CIEs. Also, two sections and one borehole located along a W-E transect, along the NW-Tethyan shelf (in the Yorkshire coast, in the E Paris Basin, and in Mecsek Basin, respectively), were investigated to assess which way calcareous nannoplankton recovered after the crisis, and if the recovery was a synchronous event. The production by nannoplankton collapsed during the T-CIE, as demonstrated by the lowest absolute abundance of nannofossils measured in Peniche and other studied sites (Mattioli et al., 2008). Besides this nannofossil abundance decrease, also the size of the incertae sedis Schizosphaerella test was drastically reduced (Suan et al., 2008b). If a similar size decrease is also recorded during the Boundary-CIE, calcareous nannofossil abundances are

[Wellbeing, team spirit and a fun run for women].

PubMed

Gougeon, Brigitte

2017-12-01

The fun run La Parisienne, has been bringing together in Paris every September for the last 21 years, thousands of women running alongside each other to say no to breast cancer. Many caregivers also take part, in teams or with friends, like at the Odysséa fun run in which families can also participate. Charity sports events for the benefit of research which promote femininity, team spirit, sharing and wellbeing. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Reliability of a Qualitative Video Analysis for Running.

PubMed

Pipkin, Andrew; Kotecki, Kristy; Hetzel, Scott; Heiderscheit, Bryan

2016-07-01

Study Design Reliability study. Background Video analysis of running gait is frequently performed in orthopaedic and sports medicine practices to assess biomechanical factors that may contribute to injury. However, the reliability of a whole-body assessment has not been determined. Objective To determine the intrarater and interrater reliability of the qualitative assessment of specific running kinematics from a 2-dimensional video. Methods Running-gait analysis was performed on videos recorded from 15 individuals (8 male, 7 female) running at a self-selected pace (3.17 ± 0.40 m/s, 8:28 ± 1:04 min/mi) using a high-speed camera (120 frames per second). These videos were independently rated on 2 occasions by 3 experienced physical therapists using a standardized qualitative assessment. Fifteen sagittal and frontal plane kinematic variables were rated on a 3- or 5-point categorical scale at specific events of the gait cycle, including initial contact (n = 3) and midstance (n = 9), or across the full gait cycle (n = 3). The video frame number corresponding to each gait event was also recorded. Intrarater and interrater reliability values were calculated for gait-event detection (intraclass correlation coefficient [ICC] and standard error of measurement [SEM]) and the individual kinematic variables (weighted kappa [κw]). Results Gait-event detection was highly reproducible within raters (ICC = 0.94-1.00; SEM, 0.3-1.0 frames) and between raters (ICC = 0.77-1.00; SEM, 0.4-1.9 frames). Eleven of the 15 kinematic variables demonstrated substantial (κw = 0.60-0.799) or excellent (κw>0.80) intrarater agreement, with the exception of foot-to-center-of-mass position (κw = 0.59), forefoot position (κw = 0.58), ankle dorsiflexion at midstance (κw = 0.49), and center-of-mass vertical excursion (κw = 0.36). Interrater agreement for the kinematic measures varied more widely (κw = 0.00-0.85), with 5 variables showing substantial or excellent reliability. Conclusion The

Is There a Lexical Bias Effect in Comprehension Monitoring?

ERIC Educational Resources Information Center

Severens, Els; Hartsuiker, Robert J.

2009-01-01

Event-related potentials were used to investigate if there is a lexical bias effect in comprehension monitoring. The lexical bias effect in language production (the tendency of phonological errors to result in existing words rather than nonwords) has been attributed to an internal self-monitoring system, which uses the comprehension system, and…

CCP MRAP Run

NASA Image and Video Library

2018-04-20

Following a training run on the Shuttle Landing Facility at NASA's Kennedy Space Center in Florida, MRAP back doors are opened showing seating in the armored vehicle. The 45,000-pound mine-resistant ambush protected vehicle, or MRAP, was originally designed for military applications, but will support the agency's Commercial Crew Program at the spaceport. The MRAP offers a mobile bunker for astronauts and ground crews in the unlikely event they have to get away from the launch pad quickly in an emergency.

Intergroup relationships do not reduce racial bias in empathic neural responses to pain.

PubMed

Contreras-Huerta, Luis Sebastian; Hielscher, Emily; Sherwell, Chase S; Rens, Natalie; Cunnington, Ross

2014-11-01

Perceiving the pain of others activates similar neural structures to those involved in the direct experience of pain, including sensory and affective-motivational areas. Empathic responses can be modulated by race, such that stronger neural activation is elicited by the perception of pain in people of the same race compared with another race. In the present study, we aimed to identify when racial bias occurs in the time course of neural empathic responses to pain. We also investigated whether group affiliation could modulate the race effect. Using the minimal group paradigm, we assigned participants to one of two mixed-race teams. We examined event-related potentials from participants when viewing members of their own and the other team receiving painful or non-painful touch. We identified a significant racial bias in early ERP components at N1 over frontal electrodes, where Painful stimuli elicited a greater negative shift relative to Non-Painful stimuli in response to own race faces only. A long latency empathic response was also found at P3, where there was significant differentiation between Painful and Non-Painful stimuli regardless of Race or Group. There was no evidence that empathy-related brain activity was modulated by minimal group manipulation. These results support a model of empathy for pain that consists of early, automatic bias towards own-race empathic responses and a later top-down cognitive evaluation that does not differentiate between races and may ultimately lead to unbiased behaviour. Copyright © 2014 Elsevier Ltd. All rights reserved.

Foot clearance in walking and running in individuals with ankle instability.

PubMed

Brown, Cathleen

2011-08-01

Foot positioning before heel strike has been attributed to chronic ankle instability injury mechanics, and may play a role in developing and perpetuating chronic ankle instability. This study was undertaken to determine if a group of individuals with mechanical instability (MI) or a group with functional instability (FI) of the ankle joint demonstrate less foot-floor clearance and a more inverted and plantar flexed position of the foot during the terminal swing phase of the running and walking cycles when compared with a group of ankle sprain copers who had an injury but no residual instability. Controlled laboratory study. Three-dimensional motion analysis was performed on 3 groups (n = 11 male athletes each) differentiated based on ankle injury history and ligamentous laxity during walking and running on a raised platform. The MI group (14.8° ± 12.0°) demonstrated greater maximum foot external rotation than the FI (3.2° ± 6.0°) and coper groups (2.9° ± 11.0°) (P = .01; η(p) (2) = .25) during running and greater rotation than the coper group during walking (3.3° ± 6.1° vs -4.5° ± 4.1°; P = .03; η(p) (2) = .21). The FI group (6.1° ± 3.2°) had greater plantar flexion at minimum than the MI group (0.1° ± 3.5°) during walking (P = .02; η(p) (2) = .25). Other group differences demonstrated large effect sizes, but not statistical significance, including unstable groups having lower minimum metatarsal height than copers during running. Differences in foot and leg position during terminal swing were observed between MI and FI groups and copers. Greater plantar flexion and lower minimum metatarsal height may increase risk for inadvertent contact and thus episodes of instability. Rehabilitation programs may need to address terminal swing to improve mechanics and avoid potential episodes of giving way at the ankle.

Early events governing memory CD8+ T-cell differentiation.

PubMed

Obar, Joshua J; Lefrançois, Leo

2010-08-01

Understanding the regulation of the CD8(+) T-cell response and how protective memory cells are generated has been intensely studied. It is now appreciated that a naive CD8(+) T cell requires at least three signals to mount an effective immune response: (i) TCR triggering, (ii) co-stimulation and (iii) inflammatory cytokines. Only recently have we begun to understand the molecular integration of those signals and how early events regulate the fate decisions of the responding CD8(+) T cells. This review will discuss the recent findings about both the extracellular and intracellular factors that regulate the destiny of responding CD8(+) T cells.

[Influence of early childhood stress exposure and traumatic life events on pain perception].

PubMed

Tesarz, J; Gerhardt, A; Eich, W

2018-06-05

Adult pain perception is influenced substantially by interactions between mind, body, and social environment during early life. Early stress exposure and traumatic life events induce powerful psychophysical stress reactions that exert multiple neurofunctional processes. This has significant implications for pain perception and pain processing. As part of this review, the complex relationships between traumatic stress experiences and associated psychobiological mechanisms of chronic pain will be discussed. Based on selected studies, psychophysiological findings are presented and possible underlying mechanisms are discussed. The article concludes with a discussion of potential implications for treatment.

Early changes in physical tree characteristics during an oak decline event in the Ozark highlands

Treesearch

Martin A. Spetich

2006-01-01

An oak decline event is severely affecting up to 120 000 ha in the Ozark National Forest of Arkansas. Results of early changes in physical tree characteristics during that event are presented. In the fall and winter of 1999 and 2000, we established research plots on a site that would become a center of severe oak decline. In August 2000, standing trees > 14 cm in...

Addressing the mischaracterization of extreme rainfall in regional climate model simulations - A synoptic pattern based bias correction approach

NASA Astrophysics Data System (ADS)

Li, Jingwan; Sharma, Ashish; Evans, Jason; Johnson, Fiona

2018-01-01

Addressing systematic biases in regional climate model simulations of extreme rainfall is a necessary first step before assessing changes in future rainfall extremes. Commonly used bias correction methods are designed to match statistics of the overall simulated rainfall with observations. This assumes that change in the mix of different types of extreme rainfall events (i.e. convective and non-convective) in a warmer climate is of little relevance in the estimation of overall change, an assumption that is not supported by empirical or physical evidence. This study proposes an alternative approach to account for the potential change of alternate rainfall types, characterized here by synoptic weather patterns (SPs) using self-organizing maps classification. The objective of this study is to evaluate the added influence of SPs on the bias correction, which is achieved by comparing the corrected distribution of future extreme rainfall with that using conventional quantile mapping. A comprehensive synthetic experiment is first defined to investigate the conditions under which the additional information of SPs makes a significant difference to the bias correction. Using over 600,000 synthetic cases, statistically significant differences are found to be present in 46% cases. This is followed by a case study over the Sydney region using a high-resolution run of the Weather Research and Forecasting (WRF) regional climate model, which indicates a small change in the proportions of the SPs and a statistically significant change in the extreme rainfall over the region, although the differences between the changes obtained from the two bias correction methods are not statistically significant.

Investigating d-cycloserine as a potential pharmacological enhancer of an emotional bias learning procedure.

PubMed

Woud, Marcella L; Blackwell, Simon E; Steudte-Schmiedgen, Susann; Browning, Michael; Holmes, Emily A; Harmer, Catherine J; Margraf, Jürgen; Reinecke, Andrea

2018-05-01

The partial N-methyl-D-aspartate receptor agonist d-cycloserine may enhance psychological therapies. However, its exact mechanism of action is still being investigated. Cognitive bias modification techniques allow isolation of cognitive processes and thus investigation of how they may be affected by d-cycloserine. We used a cognitive bias modification paradigm targeting appraisals of a stressful event, Cognitive Bias Modification-Appraisal, to investigate whether d-cycloserine enhanced the modification of appraisal, and whether it caused greater reduction in indices of psychopathology. Participants received either 250 mg of d-cycloserine ( n=19) or placebo ( n=19). As a stressor task, participants recalled a negative life event, followed by positive Cognitive Bias Modification-Appraisal training. Before and after Cognitive Bias Modification-Appraisal, appraisals and indices of psychopathology related to the stressor were assessed. Cognitive Bias Modification-Appraisal successfully modified appraisals, but d-cycloserine did not affect appraisals post-training. There were no post-training group differences in frequency of intrusions. Interestingly, d-cycloserine led to a greater reduction in distress and impact on state mood from recalling the event, and lower distress post-training was associated with fewer intrusions. Therefore, d-cycloserine may affect emotional reactivity to recalling a negative event when combined with induction of a positive appraisal style, but via a mechanism other than enhanced learning of the appraisal style.

Marine ecosystem resilience during extreme deoxygenation: the Early Jurassic oceanic anoxic event.

PubMed

Caswell, Bryony A; Frid, Christopher L J

2017-01-01

Global warming during the Early Jurassic, and associated widespread ocean deoxygenation, was comparable in scale with the changes projected for the next century. This study quantifies the impact of severe global environmental change on the biological traits of marine communities that define the ecological roles and functions they deliver. We document centennial-millennial variability in the biological trait composition of Early Jurassic (Toarcian) seafloor communities and examine how this changed during the event using biological traits analysis. Environmental changes preceding the global oceanic anoxic event (OAE) produced an ecological shift leading to stressed benthic palaeocommunities with reduced resilience to the subsequent OAE. Changes in traits and ecological succession coincided with major environmental changes; and were of similar nature and magnitude to those in severely deoxygenated benthic communities today despite the very different timescales. Changes in community composition were linked to local redox conditions whereas changes in populations of opportunists were driven by primary productivity. Throughout most of the OAE substitutions by tolerant taxa conserved the trait composition and hence functioning, but periods of severe deoxygenation caused benthic defaunation that would have resulted in functional collapse. Following the OAE recovery was slow probably because the global nature of the event restricted opportunities for recruitment from outside the basin. Our findings suggest that future systems undergoing deoxygenation may initially show functional resilience, but severe global deoxygenation will impact traits and ecosystem functioning and, by limiting the species pool, will slow recovery rates.

A comparator-hypothesis account of biased contingency detection.

PubMed

Vadillo, Miguel A; Barberia, Itxaso

2018-02-12

Our ability to detect statistical dependencies between different events in the environment is strongly biased by the number of coincidences between them. Even when there is no true covariation between a cue and an outcome, if the marginal probability of either of them is high, people tend to perceive some degree of statistical contingency between both events. The present paper explores the ability of the Comparator Hypothesis to explain the general pattern of results observed in this literature. Our simulations show that this model can account for the biasing effects of the marginal probabilities of cues and outcomes. Furthermore, the overall fit of the Comparator Hypothesis to a sample of experimental conditions from previous studies is comparable to that of the popular Rescorla-Wagner model. These results should encourage researchers to further explore and put to the test the predictions of the Comparator Hypothesis in the domain of biased contingency detection. Copyright © 2018 Elsevier B.V. All rights reserved.

Long-Run Impact of the Thirty Cent Revision in Ontario's Minimum Wage on Five Industries.

ERIC Educational Resources Information Center

McKenna, Ian B.

To determine the effect of a legislated increase in the minimum wage in Ontario, 219 establishments in five industries were surveyed. The industries were shoe factories; luggage, handbag, and small leather goods manufacturers; hosiery mills, children's clothing industry; and the foundation garment industry. Data were gathered at three different…

Matter-antimatter asymmetry induced by a running vacuum coupling

NASA Astrophysics Data System (ADS)

Lima, J. A. S.; Singleton, D.

2017-12-01

We show that a CP-violating interaction induced by a derivative coupling between the running vacuum and a non-conserving baryon current may dynamically break CPT and trigger baryogenesis through an effective chemical potential. By assuming a non-singular class of running vacuum cosmologies which provides a complete cosmic history (from an early inflationary de Sitter stage to the present day quasi-de Sitter acceleration), it is found that an acceptable baryon asymmetry is generated for many different choices of the model parameters. It is interesting that the same ingredient (running vacuum energy density) addresses several open cosmological questions/problems: avoids the initial singularity, provides a smooth exit for primordial inflation, alleviates both the coincidence and the cosmological constant problems, and, finally, is also capable of explaining the generation of matter-antimatter asymmetry in the very early Universe.

Validity of the Polar V800 monitor for measuring heart rate variability in mountain running route conditions.

PubMed

Caminal, Pere; Sola, Fuensanta; Gomis, Pedro; Guasch, Eduard; Perera, Alexandre; Soriano, Núria; Mont, Lluis

2018-03-01

This study was conducted to test, in mountain running route conditions, the accuracy of the Polar V800™ monitor as a suitable device for monitoring the heart rate variability (HRV) of runners. Eighteen healthy subjects ran a route that included a range of running slopes such as those encountered in trail and ultra-trail races. The comparative study of a V800 and a Holter SEER 12 ECG Recorder™ included the analysis of RR time series and short-term HRV analysis. A correction algorithm was designed to obtain the corrected Polar RR intervals. Six 5-min segments related to different running slopes were considered for each subject. The correlation between corrected V800 RR intervals and Holter RR intervals was very high (r = 0.99, p < 0.001), and the bias was less than 1 ms. The limits of agreement (LoA) obtained for SDNN and RMSSD were (- 0.25 to 0.32 ms) and (- 0.90 to 1.08 ms), respectively. The effect size (ES) obtained in the time domain HRV parameters was considered small (ES < 0.2). Frequency domain HRV parameters did not differ (p > 0.05) and were well correlated (r ≥ 0.96, p < 0.001). Narrow limits of agreement, high correlations and small effect size suggest that the Polar V800 is a valid tool for the analysis of heart rate variability in athletes while running high endurance events such as marathon, trail, and ultra-trail races.

Changes in running kinematics, kinetics, and spring-mass behavior over a 24-h run.

PubMed

Morin, Jean-Benoît; Samozino, Pierre; Millet, Guillaume Y

2011-05-01

This study investigated the changes in running mechanics and spring-mass behavior over a 24-h treadmill run (24TR). Kinematics, kinetics, and spring-mass characteristics of the running step were assessed in 10 experienced ultralong-distance runners before, every 2 h, and after a 24TR using an instrumented treadmill dynamometer. These measurements were performed at 10 km·h, and mechanical parameters were sampled at 1000 Hz for 10 consecutive steps. Contact and aerial times were determined from ground reaction force (GRF) signals and used to compute step frequency. Maximal GRF, loading rate, downward displacement of the center of mass, and leg length change during the support phase were determined and used to compute both vertical and leg stiffness. Subjects' running pattern and spring-mass behavior significantly changed over the 24TR with a 4.9% higher step frequency on average (because of a significantly 4.5% shorter contact time), a lower maximal GRF (by 4.4% on average), a 13.0% lower leg length change during contact, and an increase in both leg and vertical stiffness (+9.9% and +8.6% on average, respectively). Most of these changes were significant from the early phase of the 24TR (fourth to sixth hour of running) and could be speculated as contributing to an overall limitation of the potentially harmful consequences of such a long-duration run on subjects' musculoskeletal system. During a 24TR, the changes in running mechanics and spring-mass behavior show a clear shift toward a higher oscillating frequency and stiffness, along with lower GRF and leg length change (hence a reduced overall eccentric load) during the support phase of running. © 2011 by the American College of Sports Medicine

Sex differences and emotion regulation: an event-related potential study.

PubMed

Gardener, Elyse K T; Carr, Andrea R; Macgregor, Amy; Felmingham, Kim L

2013-01-01

Difficulties in emotion regulation have been implicated as a potential mechanism underlying anxiety and mood disorders. It is possible that sex differences in emotion regulation may contribute towards the heightened female prevalence for these disorders. Previous fMRI studies of sex differences in emotion regulation have shown mixed results, possibly due to difficulties in discriminating the component processes of early emotional reactivity and emotion regulation. The present study used event-related potentials (ERPs) to examine sex differences in N1 and N2 components (reflecting early emotional reactivity) and P3 and LPP components (reflecting emotion regulation). N1, N2, P3, and LPP were recorded from 20 men and 23 women who were instructed to "increase," "decrease," and "maintain" their emotional response during passive viewing of negative images. Results indicated that women had significantly greater N1 and N2 amplitudes (reflecting early emotional reactivity) to negative stimuli than men, supporting a female negativity bias. LPP amplitudes increased to the "increase" instruction, and women displayed greater LPP amplitudes than men to the "increase" instruction. There were no differences to the "decrease" instruction in women or men. These findings confirm predictions of the female negativity bias hypothesis and suggest that women have greater up-regulation of emotional responses to negative stimuli. This finding is highly significant in light of the female vulnerability for developing anxiety disorders.

Dependence of Halo Bias and Kinematics on Assembly Variables

NASA Astrophysics Data System (ADS)

Xu, Xiaoju; Zheng, Zheng

2018-06-01

Using dark matter haloes identified in a large N-body simulation, we study halo assembly bias, with halo formation time, peak maximum circular velocity, concentration, and spin as the assembly variables. Instead of grouping haloes at fixed mass into different percentiles of each assembly variable, we present the joint dependence of halo bias on the values of halo mass and each assembly variable. In the plane of halo mass and one assembly variable, the joint dependence can be largely described as halo bias increasing outward from a global minimum. We find it unlikely to have a combination of halo variables to absorb all assembly bias effects. We then present the joint dependence of halo bias on two assembly variables at fixed halo mass. The gradient of halo bias does not necessarily follow the correlation direction of the two assembly variables and it varies with halo mass. Therefore in general for two correlated assembly variables one cannot be used as a proxy for the other in predicting halo assembly bias trend. Finally, halo assembly is found to affect the kinematics of haloes. Low-mass haloes formed earlier can have much higher pairwise velocity dispersion than those of massive haloes. In general, halo assembly leads to a correlation between halo bias and halo pairwise velocity distribution, with more strongly clustered haloes having higher pairwise velocity and velocity dispersion. However, the correlation is not tight, and the kinematics of haloes at fixed halo bias still depends on halo mass and assembly variables.

Developmental bias in cleavage-stage mouse blastomeres

PubMed Central

Tabansky, Inna; Lenarcic, Alan; Draft, Ryan W.; Loulier, Karine; Keskin, Derin B; Rosains, Jacqueline; Rivera-Feliciano, José; Lichtman, Jeff W.; Livet, Jean; Stern, Joel NH; Sanes, Joshua R.; Eggan, Kevin

2012-01-01

Summary Introduction The cleavage stage mouse embryo is composed of superficially equivalent blastomeres that will generate both the embryonic inner cell mass (ICM) and the supportive trophectoderm (TE). However, it remains unsettled whether the contribution of each blastomere to these two lineages can be accounted for by chance. Addressing the question of blastomere cell fate may be of practical importance, as preimplantation genetic diagnosis (PGD) requires removal of blastomeres from the early human embryo. To determine if blastomere allocation to the two earliest lineages is random, we developed and utilized a recombination-mediated, non-invasive combinatorial fluorescent labeling method for embryonic lineage tracing. Results When we induced recombination at cleavage stages, we observed a statistically significant bias in the contribution of the resulting labeled clones to the trophectoderm or the inner cell mass in a subset of embryos. Surprisingly, we did not find a correlation between localization of clones in the embryonic and abembryonic hemispheres of the late blastocyst and their allocation to the TE and ICM, suggesting that TE-ICM bias arises separately from embryonic-abembryonic bias. Rainbow lineage tracing also allowed us to demonstrate that the bias observed in the blastocyst persists into post-implantation stages, and therefore has relevance for subsequent development. Discussion The Rainbow transgenic mice that we describe here have allowed us to detect lineage-dependent bias in early development. They should also enable assessment of the developmental equivalence of mammalian progenitor cells in a variety of tissues. PMID:23177476

Anxiety-Linked Expectancy Bias across the Adult Lifespan

PubMed Central

Steinman, Shari A.; Smyth, Frederick L.; Bucks, Romola S.; MacLeod, Colin; Teachman, Bethany A.

2012-01-01

Anxiety is characterized by a negative expectancy bias, such that anxious individuals report negatively distorted expectations about the future. Contrary to anxiety, aging is characterized by a positivity effect, such that aging is associated with a tendency to attend to and remember positive information, relative to negative information. The current study integrates these literatures to examine anxiety- and age-linked biases when thinking about the future. Participants (N=1109) completed a procedure that involved reading valenced scenarios (positive, negative, or ambiguous) and then rating the likelihood of future valenced events occurring. Results suggest that aging and anxiety have independent and opposing effects. Heightened anxiety was associated with a reduced expectancy for positive events, regardless of the scenarios’ current emotional valence, whereas increased age was associated with an inflated expectancy for positive events, which was strongest when individuals were processing socially-relevant or negative scenarios. PMID:22861128

Running Mechanics and Variability with Aging.

PubMed

Silvernail, Julia Freedman; Boyer, Katherine; Rohr, Eric; Brüggemann, Gert-Peter; Hamill, Joseph

2015-10-01

As the elderly population in the United States continues to grow, issues related to maintenance of health become increasingly important. Physical activity has positive benefits for healthy aging. Running, a popular form of exercise, is associated with the risk of developing injury, especially in older runners. Initial differences between older and younger runners have been observed, but these were observed without consideration of other differences between groups, such as running mileage. This study aims to compare running mechanics and lower-extremity coordination variability in matched groups of healthy younger and healthy older runners. Three-dimensional kinetics and kinematics were collected while 14 older adults (45-65 yr) and younger adults (18-35 yr) ran overground at 3.5 m·s. Knee, ankle, and hip joint angles and moments were determined. Discrete measures at foot strike (maximum and minimum) were determined and compared between groups. Segment angles during stance were utilized to calculate segment coordination variability between pelvis and thigh, thigh and shank, and shank and foot, using a modified vector coding technique. Knee and ankle joint angles were similar between groups (P > 0.05). Older runners had greater hip range of motion (P = 0.01) and peak hip flexion (P = 0.001) at a more extended hip position than younger runners. Older runners had smaller ankle plantarflexion moment (P = 0.04) and hip rotational moment (P = 0.005) than younger runners. There were no between-group differences in any of the variability measures (P > 0.05). Runners appear to maintain movement patterns and variability during running with increasing age, indicating that running itself may be contributing to maintenance of health among older runners in the current study.

Early events in copper-ion catalyzed oxidation of α-synuclein.

PubMed

Tiwari, Manish K; Leinisch, Fabian; Sahin, Cagla; Møller, Ian Max; Otzen, Daniel E; Davies, Michael J; Bjerrum, Morten J

2018-04-22

Previous studies on metal-ion catalyzed oxidation of α-synuclein oxidation have mostly used conditions that result in extensive modification precluding an understanding of the early events in this process. In this study, we have examined time-dependent oxidative events related to α-synuclein modification using six different molar ratios of Cu 2+ /H 2 O 2 /protein and Cu 2+ /H 2 O 2 /ascorbate/protein resulting in mild to moderate extents of oxidation. For a Cu 2+ /H 2 O 2 /protein molar ratio of 2.3:7.8:1 only low levels of carbonyls were detected (0.078 carbonyls per protein), whereas a molar ratio of 4.7:15.6:1 gave 0.22 carbonyls per α-synuclein within 15 min. With the latter conditions, rapid conversion of 3 out of 4 methionines (Met) to methionine sulfoxide, and 2 out of 4 tyrosines (Tyr) were converted to products including inter- and intra-molecular dityrosine cross-links and protein oligomers, as determined by SDS-PAGE and Western blot analysis. Limited histidine (His) modification was observed. The rapid formation of dityrosine cross-links was confirmed by fluorescence and mass-spectrometry. These data indicate that Met and Tyr oxidation are early events in Cu 2+ /H 2 O 2 -mediated damage, with carbonyl formation being a minor process. With the Cu 2+ /H 2 O 2 /ascorbate system, rapid protein carbonyl formation was detected with the first 5 min, but after this time point, little additional carbonyl formation was detected. With this system, lower levels of Met and Tyr oxidation were detected (2 Met and 1 Tyr modified with a Cu 2+ /H 2 O 2 /ascorbate/protein ratio of 2.3:7.8:7.8:1), but greater His oxidation. Only low levels of intra- dityrosine cross-links and no inter- dityrosine oligomers were detected under these conditions, suggesting that ascorbate limits Cu 2+ /H 2 O 2 -induced α-synuclein modification. Copyright © 2018. Published by Elsevier Inc.

Detection of rain events in radiological early warning networks with spectro-dosimetric systems

NASA Astrophysics Data System (ADS)

Dąbrowski, R.; Dombrowski, H.; Kessler, P.; Röttger, A.; Neumaier, S.

2017-10-01

Short-term pronounced increases of the ambient dose equivalent rate, due to rainfall are a well-known phenomenon. Increases in the same order of magnitude or even below may also be caused by a nuclear or radiological event, i.e. by artificial radiation. Hence, it is important to be able to identify natural rain events in dosimetric early warning networks and to distinguish them from radiological events. Novel spectrometric systems based on scintillators may be used to differentiate between the two scenarios, because the measured gamma spectra provide significant nuclide-specific information. This paper describes three simple, automatic methods to check whether an dot H*(10) increase is caused by a rain event or by artificial radiation. These methods were applied to measurements of three spectrometric systems based on CeBr3, LaBr3 and SrI2 scintillation crystals, investigated and tested for their practicability at a free-field reference site of PTB.

Synopsis of key persons, events, and associations in the history of Latino psychology.

PubMed

Padilla, Amado M; Olmedo, Esteban

2009-10-01

In this article, we present a brief synopsis of six early Latino psychologists, several key conferences, the establishment of research centers, and early efforts to create an association for Latino psychologists. Our chronology runs from approximately 1930 to 2000. This history is a firsthand account of how these early leaders, conferences, and efforts to bring Latinos and Latinas together served as a backdrop to current research and practice in Latino psychology. This history of individuals and events is also intertwined with the American Psychological Association and the National Institute of Mental Health and efforts by Latino psychologists to obtain the professional support necessary to lay down the roots of a Latino presence in psychology. Copyright 2009 APA, all rights reserved.

Lost in translation: Review of identification bias, translation bias and research waste in dentistry.

PubMed

Layton, Danielle M; Clarke, Michael

2016-01-01

To review how articles are retrieved from bibliographic databases, what article identification and translation problems have affected research, and how these problems can contribute to research waste and affect clinical practice. This literature review sought and appraised articles regarding identification- and translation-bias in the medical and dental literature, which limit the ability of users to find research articles and to use these in practice. Articles can be retrieved from bibliographic databases by performing a word or index-term (for example, MeSH for MEDLINE) search. Identification of articles is challenging when it is not clear which words are most relevant, and which terms have been allocated to indexing fields. Poor reporting quality of abstracts and articles has been reported across the medical literature at large. Specifically in dentistry, research regarding time-to-event survival analyses found the allocation of MeSH terms to be inconsistent and inaccurate, important words were omitted from abstracts by authors, and the quality of reporting in the body of articles was generally poor. These shortcomings mean that articles will be difficult to identify, and difficult to understand if found. Use of specialized electronic search strategies can decrease identification bias, and use of tailored reporting guidelines can decrease translation bias. Research that cannot be found, or cannot be used results in research waste, and undermines clinical practice. Identification- and translation-bias have been shown to affect time-to-event dental articles, are likely affect other fields of research, and are largely unrecognized by authors and evidence seekers alike. By understanding that the problems exist, solutions can be sought to improve identification and translation of our research. Copyright © 2015 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

Analyzing time-ordered event data with missed observations.

PubMed

Dokter, Adriaan M; van Loon, E Emiel; Fokkema, Wimke; Lameris, Thomas K; Nolet, Bart A; van der Jeugd, Henk P

2017-09-01

A common problem with observational datasets is that not all events of interest may be detected. For example, observing animals in the wild can difficult when animals move, hide, or cannot be closely approached. We consider time series of events recorded in conditions where events are occasionally missed by observers or observational devices. These time series are not restricted to behavioral protocols, but can be any cyclic or recurring process where discrete outcomes are observed. Undetected events cause biased inferences on the process of interest, and statistical analyses are needed that can identify and correct the compromised detection processes. Missed observations in time series lead to observed time intervals between events at multiples of the true inter-event time, which conveys information on their detection probability. We derive the theoretical probability density function for observed intervals between events that includes a probability of missed detection. Methodology and software tools are provided for analysis of event data with potential observation bias and its removal. The methodology was applied to simulation data and a case study of defecation rate estimation in geese, which is commonly used to estimate their digestive throughput and energetic uptake, or to calculate goose usage of a feeding site from dropping density. Simulations indicate that at a moderate chance to miss arrival events ( p  = 0.3), uncorrected arrival intervals were biased upward by up to a factor 3, while parameter values corrected for missed observations were within 1% of their true simulated value. A field case study shows that not accounting for missed observations leads to substantial underestimates of the true defecation rate in geese, and spurious rate differences between sites, which are introduced by differences in observational conditions. These results show that the derived methodology can be used to effectively remove observational biases in time-ordered event

Ancient X chromosomes reveal contrasting sex bias in Neolithic and Bronze Age Eurasian migrations.

PubMed

Goldberg, Amy; Günther, Torsten; Rosenberg, Noah A; Jakobsson, Mattias

2017-03-07

Dramatic events in human prehistory, such as the spread of agriculture to Europe from Anatolia and the late Neolithic/Bronze Age migration from the Pontic-Caspian Steppe, can be investigated using patterns of genetic variation among the people who lived in those times. In particular, studies of differing female and male demographic histories on the basis of ancient genomes can provide information about complexities of social structures and cultural interactions in prehistoric populations. We use a mechanistic admixture model to compare the sex-specifically-inherited X chromosome with the autosomes in 20 early Neolithic and 16 late Neolithic/Bronze Age human remains. Contrary to previous hypotheses suggested by the patrilocality of many agricultural populations, we find no evidence of sex-biased admixture during the migration that spread farming across Europe during the early Neolithic. For later migrations from the Pontic Steppe during the late Neolithic/Bronze Age, however, we estimate a dramatic male bias, with approximately five to 14 migrating males for every migrating female. We find evidence of ongoing, primarily male, migration from the steppe to central Europe over a period of multiple generations, with a level of sex bias that excludes a pulse migration during a single generation. The contrasting patterns of sex-specific migration during these two migrations suggest a view of differing cultural histories in which the Neolithic transition was driven by mass migration of both males and females in roughly equal numbers, perhaps whole families, whereas the later Bronze Age migration and cultural shift were instead driven by male migration, potentially connected to new technology and conquest.

Back bias induced dynamic and steep subthreshold swing in junctionless transistors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parihar, Mukta Singh; Kranti, Abhinav, E-mail: akranti@iiti.ac.in

In this work, we analyze back bias induced steep and dynamic subthreshold swing in junctionless double gate transistors operated in the asymmetric mode. This impact ionization induced dynamic subthreshold swing is explained in terms of the ratio between minimum hole concentration and peak electron concentration, and the dynamic change in the location of the conduction channel with applied front gate voltage. The reason for the occurrence of impact ionization at sub-bandgap drain voltages in silicon junctionless transistors is also accounted for. The optimum junctionless transistor operating at a back gate bias of −0.9 V, achieves over 5 orders of change inmore » drain current at a gate overdrive of 200 mV and drain bias of 1 V. These results for junctionless transistors are significantly better than those exhibited by silicon tunnel field effect transistors operating at the same drain bias.« less

Change-in-ratio density estimator for feral pigs is less biased than closed mark-recapture estimates

USGS Publications Warehouse

Hanson, L.B.; Grand, J.B.; Mitchell, M.S.; Jolley, D.B.; Sparklin, B.D.; Ditchkoff, S.S.

2008-01-01

Closed-population capture-mark-recapture (CMR) methods can produce biased density estimates for species with low or heterogeneous detection probabilities. In an attempt to address such biases, we developed a density-estimation method based on the change in ratio (CIR) of survival between two populations where survival, calculated using an open-population CMR model, is known to differ. We used our method to estimate density for a feral pig (Sus scrofa) population on Fort Benning, Georgia, USA. To assess its validity, we compared it to an estimate of the minimum density of pigs known to be alive and two estimates based on closed-population CMR models. Comparison of the density estimates revealed that the CIR estimator produced a density estimate with low precision that was reasonable with respect to minimum known density. By contrast, density point estimates using the closed-population CMR models were less than the minimum known density, consistent with biases created by low and heterogeneous capture probabilities for species like feral pigs that may occur in low density or are difficult to capture. Our CIR density estimator may be useful for tracking broad-scale, long-term changes in species, such as large cats, for which closed CMR models are unlikely to work. ?? CSIRO 2008.

Negativity Bias in Dangerous Drivers.

PubMed

Chai, Jing; Qu, Weina; Sun, Xianghong; Zhang, Kan; Ge, Yan

2016-01-01

The behavioral and cognitive characteristics of dangerous drivers differ significantly from those of safe drivers. However, differences in emotional information processing have seldom been investigated. Previous studies have revealed that drivers with higher anger/anxiety trait scores are more likely to be involved in crashes and that individuals with higher anger traits exhibit stronger negativity biases when processing emotions compared with control groups. However, researchers have not explored the relationship between emotional information processing and driving behavior. In this study, we examined the emotional information processing differences between dangerous drivers and safe drivers. Thirty-eight non-professional drivers were divided into two groups according to the penalty points that they had accrued for traffic violations: 15 drivers with 6 or more points were included in the dangerous driver group, and 23 drivers with 3 or fewer points were included in the safe driver group. The emotional Stroop task was used to measure negativity biases, and both behavioral and electroencephalograph data were recorded. The behavioral results revealed stronger negativity biases in the dangerous drivers than in the safe drivers. The bias score was correlated with self-reported dangerous driving behavior. Drivers with strong negativity biases reported having been involved in mores crashes compared with the less-biased drivers. The event-related potentials (ERPs) revealed that the dangerous drivers exhibited reduced P3 components when responding to negative stimuli, suggesting decreased inhibitory control of information that is task-irrelevant but emotionally salient. The influence of negativity bias provides one possible explanation of the effects of individual differences on dangerous driving behavior and traffic crashes.

Bias in the Wagner-Nelson estimate of the fraction of drug absorbed.

PubMed

Wang, Yibin; Nedelman, Jerry

2002-04-01

To examine and quantify bias in the Wagner-Nelson estimate of the fraction of drug absorbed resulting from the estimation error of the elimination rate constant (k), measurement error of the drug concentration, and the truncation error in the area under the curve. Bias in the Wagner-Nelson estimate was derived as a function of post-dosing time (t), k, ratio of absorption rate constant to k (r), and the coefficient of variation for estimates of k (CVk), or CV% for the observed concentration, by assuming a one-compartment model and using an independent estimate of k. The derived functions were used for evaluating the bias with r = 0.5, 3, or 6; k = 0.1 or 0.2; CV, = 0.2 or 0.4; and CV, =0.2 or 0.4; for t = 0 to 30 or 60. Estimation error of k resulted in an upward bias in the Wagner-Nelson estimate that could lead to the estimate of the fraction absorbed being greater than unity. The bias resulting from the estimation error of k inflates the fraction of absorption vs. time profiles mainly in the early post-dosing period. The magnitude of the bias in the Wagner-Nelson estimate resulting from estimation error of k was mainly determined by CV,. The bias in the Wagner-Nelson estimate resulting from to estimation error in k can be dramatically reduced by use of the mean of several independent estimates of k, as in studies for development of an in vivo-in vitro correlation. The truncation error in the area under the curve can introduce a negative bias in the Wagner-Nelson estimate. This can partially offset the bias resulting from estimation error of k in the early post-dosing period. Measurement error of concentration does not introduce bias in the Wagner-Nelson estimate. Estimation error of k results in an upward bias in the Wagner-Nelson estimate, mainly in the early drug absorption phase. The truncation error in AUC can result in a downward bias, which may partially offset the upward bias due to estimation error of k in the early absorption phase. Measurement error of

On the estimation of intracluster correlation for time-to-event outcomes in cluster randomized trials.

PubMed

Kalia, Sumeet; Klar, Neil; Donner, Allan

2016-12-30

Cluster randomized trials (CRTs) involve the random assignment of intact social units rather than independent subjects to intervention groups. Time-to-event outcomes often are endpoints in CRTs. Analyses of such data need to account for the correlation among cluster members. The intracluster correlation coefficient (ICC) is used to assess the similarity among binary and continuous outcomes that belong to the same cluster. However, estimating the ICC in CRTs with time-to-event outcomes is a challenge because of the presence of censored observations. The literature suggests that the ICC may be estimated using either censoring indicators or observed event times. A simulation study explores the effect of administrative censoring on estimating the ICC. Results show that ICC estimators derived from censoring indicators or observed event times are negatively biased. Analytic work further supports these results. Observed event times are preferred to estimate the ICC under minimum frequency of administrative censoring. To our knowledge, the existing literature provides no practical guidance on the estimation of ICC when substantial amount of administrative censoring is present. The results from this study corroborate the need for further methodological research on estimating the ICC for correlated time-to-event outcomes. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

The Effects of Spectral Nudging on Arctic Temperature and Precipitation Extremes as Produced by the Pan-Arctic WRF

NASA Astrophysics Data System (ADS)

Glisan, J. M.; Gutowski, W. J.; Higgins, M.; Cassano, J. J.

2011-12-01

Pan-Arctic WRF (PAW) simulations produced using the 50-km wr50a domain developed for the fully-coupled Regional Arctic Climate Model (RACM) were found to produce deep atmospheric circulation biases over the northern Pacific Ocean, manifested in pressure, geopotential height, and temperature fields. Various remedies were unsuccessfully tested to correct these large biases, such as modifying the physical domain or using different initial/boundary conditions. Spectral (interior) nudging was introduced as a way of constraining the model to be more consistent with observed behavior. However, such control over numerical model behavior raises concerns over how much nudging may affect unforced variability and extremes. Strong nudging may reduce or filter out extreme events, since the nudging pushes the model toward a relatively smooth, large-scale state. The question then becomes - what is the minimum spectral nudging needed to correct the biases occurring on the RACM domain while not limiting PAW simulation of extreme events? To determine this, case studies were devised, using a six-member PAW ensemble on the RACM grid with varying spectral nudging strength. Two simulations were run, one in the cold season (January 2007) and one in a warm season (July 2007). Precipitation and 2-m temperature fields were extracted from the output and analyzed to determine how changing spectral nudging strength impacts both temporal and spatial temperature and precipitation extremes. The maximum and minimum temperatures at each point from among the ensemble members were examined, on the 95th confidence interval. The maximum and minimums over the simulation period will also be considered. Results suggest that there is a marked lack of sensitivity to the degrees of nudging. Moreover, it appears nudging strength can be considerably smaller than the standard strength and still produce reliably good simulations.

Fluid simulation of the bias effect in inductive/capacitive discharges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Yu-Ru; Research Group PLASMANT, Department of Chemistry, University of Antwerp, Universiteitsplein 1, Wilrijk, BE-2610 Antwerp; Gao, Fei

Computer simulations are performed for an argon inductively coupled plasma (ICP) with a capacitive radio-frequency bias power, to investigate the bias effect on the discharge mode transition and on the plasma characteristics at various ICP currents, bias voltages, and bias frequencies. When the bias frequency is fixed at 13.56 MHz and the ICP current is low, e.g., 6 A, the spatiotemporal averaged plasma density increases monotonically with bias voltage, and the bias effect is already prominent at a bias voltage of 90 V. The maximum of the ionization rate moves toward the bottom electrode, which indicates clearly the discharge mode transition in inductive/capacitivemore » discharges. At higher ICP currents, i.e., 11 and 13 A, the plasma density decreases first and then increases with bias voltage, due to the competing mechanisms between the ion acceleration power dissipation and the capacitive power deposition. At 11 A, the bias effect is still important, but it is noticeable only at higher bias voltages. At 13 A, the ionization rate is characterized by a maximum at the reactor center near the dielectric window at all selected bias voltages, which indicates that the ICP power, instead of the bias power, plays a dominant role under this condition, and no mode transition is observed. Indeed, the ratio of the bias power to the total power is lower than 0.4 over a wide range of bias voltages, i.e., 0–300 V. Besides the effect of ICP current, also the effect of various bias frequencies is investigated. It is found that the modulation of the bias power to the spatiotemporal distributions of the ionization rate at 2 MHz is strikingly different from the behavior observed at higher bias frequencies. Furthermore, the minimum of the plasma density appears at different bias voltages, i.e., 120 V at 2 MHz and 90 V at 27.12 MHz.« less

Importance of understanding landscape biases in USGS gage locations: Implications and solutions for managers

USGS Publications Warehouse

Wagner, Tyler; DeWeber, Jefferson Tyrell; Tsang, Yin-Phan; Krueger, Damon; Whittier, Joanna B.; Infante, Dana M.; Whelan, Gary

2014-01-01

Flow and water temperature are fundamental properties of stream ecosystems upon which many freshwater resource management decisions are based. U.S. Geological Survey (USGS) gages are the most important source of streamflow and water temperature data available nationwide, but the degree to which gages represent landscape attributes of the larger population of streams has not been thoroughly evaluated. We identified substantial biases for seven landscape attributes in one or more regions across the conterminous United States. Streams with small watersheds (<10 km2) and at high elevations were often underrepresented, and biases were greater for water temperature gages and in arid regions. Biases can fundamentally alter management decisions and at a minimum this potential for error must be acknowledged accurately and transparently. We highlight three strategies that seek to reduce bias or limit errors arising from bias and illustrate how one strategy, supplementing USGS data, can greatly reduce bias.

LES study of microphysical variability bias in shallow cumulus

NASA Astrophysics Data System (ADS)

Kogan, Yefim

2017-05-01

Subgrid-scale (SGS) variability of cloud microphysical variables over the mesoscale numerical weather prediction (NWP) model has been evaluated by means of joint probability distribution functions (JPDFs). The latter were obtained using dynamically balanced Large Eddy Simulation (LES) model dataset from a case of marine trade cumulus initialized with soundings from Rain in Cumulus Over the Ocean (RICO) field project. Bias in autoconversion and accretion rates from different formulations of the JPDFs was analyzed. Approximating the 2-D PDF using a generic (fixed-in-time), but variable-in-height JPDFs give an acceptable level of accuracy, whereas neglecting the SGS variability altogether results in a substantial underestimate of the grid-mean total conversion rate and producing negative bias in rain water. Nevertheless the total effect on rain formation may be uncertain in the long run due to the fact that the negative bias in rain water may be counterbalanced by the positive bias in cloud water. Consequently, the overall effect of SGS neglect needs to be investigated in direct simulations with a NWP model.

Developing a medical emergency team running sheet to improve clinical handoff and documentation.

PubMed

Mardegan, Karen; Heland, Melodie; Whitelock, Tifany; Millar, Robert; Jones, Daryl

2013-12-01

During medical emergency team (MET) and cardiac arrest calls, a scribe usually records events on a running sheet. There is more agreement on what data should be recorded in cardiac arrest calls than for MET calls. In addition, handoff (handover) from ward staff to the arriving MET may be variable. In a quality improvement project, a novel MET running sheet was developed to document events and therapies administered during MET calls. Key characteristics of the form were improved form layout, increased space for event documentation, and prompts to assist handoff to the arriving MET using the Identity Situation, Background, Assessment, Request (ISBAR) format. Ward nurses commonly involved in MET activation were surveyed to assess their perceptions of the new MET running sheet. Files of 100 consecutive MET calls were reviewed to assess compliance. Of 109 nurses invited to complete the survey, 103 did so (94.5% response rate). Overall, 87 (84.5%) of the 103 respondents agreed or strongly agreed that the new MET running sheet was better than the previous form for documenting MET management, and 58 (57.4%) of 101 respondents agreed or strongly agreed that it assisted handoff. The form was completed in 91 of a sample of 100 consecutive MET calls. Areas of less complete documentation included aspects of the ISBAR handover to the arriving MET and notification of the next of kin and usual clinicians at the completion of the call. The MET running sheet, tailored to the clinical events that occur during episodes of MET review, may assist handoff from ward nurses to the arriving MET and event documentation.

7 CFR 33.10 - Minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... ISSUED UNDER AUTHORITY OF THE EXPORT APPLE ACT Regulations § 33.10 Minimum requirements. No person shall... shipment of apples to any foreign destination unless: (a) Apples grade at least U.S. No. 1 or U.S. No. 1 Early: Provided, That apples for export to Pacific ports of Russia shall grade at least U.S. Utility or...

7 CFR 33.10 - Minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... ISSUED UNDER AUTHORITY OF THE EXPORT APPLE ACT Regulations § 33.10 Minimum requirements. No person shall... shipment of apples to any foreign destination unless: (a) Apples grade at least U.S. No. 1 or U.S. No. 1 Early: Provided, That apples for export to Pacific ports of Russia shall grade at least U.S. Utility or...

7 CFR 33.10 - Minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... ISSUED UNDER AUTHORITY OF THE EXPORT APPLE ACT Regulations § 33.10 Minimum requirements. No person shall... shipment of apples to any foreign destination unless: (a) Apples grade at least U.S. No. 1 or U.S. No. 1 Early: Provided, That apples for export to Pacific ports of Russia shall grade at least U.S. Utility or...

7 CFR 33.10 - Minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... ISSUED UNDER AUTHORITY OF THE EXPORT APPLE ACT Regulations § 33.10 Minimum requirements. No person shall... shipment of apples to any foreign destination unless: (a) Apples grade at least U.S. No. 1 or U.S. No. 1 Early: Provided, That apples for export to Pacific ports of Russia shall grade at least U.S. Utility or...

7 CFR 33.10 - Minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... ISSUED UNDER AUTHORITY OF THE EXPORT APPLE ACT Regulations § 33.10 Minimum requirements. No person shall... shipment of apples to any foreign destination unless: (a) Apples grade at least U.S. No. 1 or U.S. No. 1 Early: Provided, That apples for export to Pacific ports of Russia shall grade at least U.S. Utility or...

Bias against research on gender bias.

PubMed

Cislak, Aleksandra; Formanowicz, Magdalena; Saguy, Tamar

2018-01-01

The bias against women in academia is a documented phenomenon that has had detrimental consequences, not only for women, but also for the quality of science. First, gender bias in academia affects female scientists, resulting in their underrepresentation in academic institutions, particularly in higher ranks. The second type of gender bias in science relates to some findings applying only to male participants, which produces biased knowledge. Here, we identify a third potentially powerful source of gender bias in academia: the bias against research on gender bias. In a bibliometric investigation covering a broad range of social sciences, we analyzed published articles on gender bias and race bias and established that articles on gender bias are funded less often and published in journals with a lower Impact Factor than articles on comparable instances of social discrimination. This result suggests the possibility of an underappreciation of the phenomenon of gender bias and related research within the academic community. Addressing this meta-bias is crucial for the further examination of gender inequality, which severely affects many women across the world.

Incidence of paediatric fatal and non-fatal low speed vehicle run over events in Queensland, Australia: eleven year analysis

PubMed Central

2014-01-01

Background The purpose of this study was to estimate the incidence of fatal and non-fatal Low Speed Vehicle Run Over (LSVRO) events among children aged 0–15 years in Queensland, Australia, at a population level. Methods Fatal and non-fatal LSVRO events that occurred in children resident in Queensland over eleven calendar years (1999-2009) were identified using ICD codes, text description, word searches and medical notes clarification, obtained from five health related data bases across the continuum of care (pre-hospital to fatality). Data were manually linked. Population data provided by the Australian Bureau of Statistics were used to calculate crude incidence rates for fatal and non-fatal LSVRO events. Results There were 1611 LSVROs between 1999–2009 (IR = 16.87/100,000/annum). Incidence of non-fatal events (IR = 16.60/100,000/annum) was 61.5 times higher than fatal events (IR = 0.27/100,000/annum). LSVRO events were more common in boys (IR = 20.97/100,000/annum) than girls (IR = 12.55/100,000/annum), and among younger children aged 0–4 years (IR = 21.45/100000/annum; 39% or all events) than older children (5–9 years: IR = 16.47/100,000/annum; 10–15 years IR = 13.59/100,000/annum). A total of 896 (56.8%) children were admitted to hospital for 24 hours of more following an LSVRO event (IR = 9.38/100,000/annum). Total LSVROs increased from 1999 (IR = 14.79/100,000) to 2009 (IR = 18.56/100,000), but not significantly. Over the 11 year period, there was a slight (non –significant) increase in fatalities (IR = 0.37-0.42/100,000/annum); a significant decrease in admissions (IR = 12.39–5.36/100,000/annum), and significant increase in non-admissions (IR = 2.02-12.77/100,000/annum). Trends over time differed by age, gender and severity. Conclusion This is the most comprehensive, population-based epidemiological study on fatal and non-fatal LSVRO events to date. Results from this study indicate

LHCb detector and trigger performance in Run II

NASA Astrophysics Data System (ADS)

Francesca, Dordei

2017-12-01

The LHCb detector is a forward spectrometer at the LHC, designed to perform high precision studies of b- and c- hadrons. In Run II of the LHC, a new scheme for the software trigger at LHCb allows splitting the triggering of events into two stages, giving room to perform the alignment and calibration in real time. In the novel detector alignment and calibration strategy for Run II, data collected at the start of the fill are processed in a few minutes and used to update the alignment, while the calibration constants are evaluated for each run. This allows identical constants to be used in the online and offline reconstruction, thus improving the correlation between triggered and offline selected events. The required computing time constraints are met thanks to a new dedicated framework using the multi-core farm infrastructure for the trigger. The larger timing budget, available in the trigger, allows to perform the same track reconstruction online and offline. This enables LHCb to achieve the best reconstruction performance already in the trigger, and allows physics analyses to be performed directly on the data produced by the trigger reconstruction. The novel real-time processing strategy at LHCb is discussed from both the technical and operational point of view. The overall performance of the LHCb detector on the data of Run II is presented as well.

Ar-Ar Dating of Martian Meteorite, Dhofar 378: An Early Shock Event?

NASA Technical Reports Server (NTRS)

Park, J.; Bogard, D. D.

2006-01-01

Martian meteorite, Dhofar 378 (Dho378) is a basaltic shergottite from Oman, weighing 15 g, and possessing a black fusion crust. Chemical similarities between Dho378 and the Los Angeles 001 shergottite suggests that they might have derived from the same Mars locale. The plagioclase in other shergottites has been converted to maskelenite by shock, but Dho378 apparently experienced even more intense shock heating, estimated at 55-75 GPa. Dho378 feldspar (approximately 43 modal %) melted, partially flowed and vesiculated, and then partially recrystallized. Areas of feldspathic glass are appreciably enriched in K, whereas individual plagioclases show a range in the Or/An ratio of approximately 0.18-0.017. Radiometric dating of martian shergottites indicate variable formation times of 160-475 Myr, whereas cosmic ray exposure (CRE) ages of shergottites indicate most were ejected from Mars within the past few Myr. Most determined Ar-39-Ar-40 ages of shergottites appear older than other radiometric ages because of the presence of large amounts of martian atmosphere or interior Ar-40. Among all types of meteorites and returned lunar rocks, the impact event that initiated the CRE age very rarely reset the Ar-Ar age. This is because a minimum time and temperature is required to facilitate Ar diffusion loss. It is generally assumed that the shock-texture characteristics in martian meteorites were produced by the impact events that ejected the rocks from Mars, although the time of these shock events (as opposed to CRE ages) are not directly dated. Here we report Ar-39-Ar-40 dating of Dho378 plagioclase. We suggest that the determined age dates the intense shock heating event this meteorite experienced, but that it was not the impact that initiated the CRE age.

Vowel bias in Danish word-learning: processing biases are language-specific.

PubMed

Højen, Anders; Nazzi, Thierry

2016-01-01

The present study explored whether the phonological bias favoring consonants found in French-learning infants and children when learning new words (Havy & Nazzi, 2009; Nazzi, 2005) is language-general, as proposed by Nespor, Peña and Mehler (2003), or varies across languages, perhaps as a function of the phonological or lexical properties of the language in acquisition. To do so, we used the interactive word-learning task set up by Havy and Nazzi (2009), teaching Danish-learning 20-month-olds pairs of phonetically similar words that contrasted either on one of their consonants or one of their vowels, by either one or two phonological features. Danish was chosen because it has more vowels than consonants, and is characterized by extensive consonant lenition. Both phenomena could disfavor a consonant bias. Evidence of word-learning was found only for vocalic information, irrespective of whether one or two phonological features were changed. The implication of these findings is that the phonological biases found in early lexical processing are not language-general but develop during language acquisition, depending on the phonological or lexical properties of the native language. © 2015 John Wiley & Sons Ltd.

Complex Event Recognition Architecture

NASA Technical Reports Server (NTRS)

Fitzgerald, William A.; Firby, R. James

2009-01-01

Complex Event Recognition Architecture (CERA) is the name of a computational architecture, and software that implements the architecture, for recognizing complex event patterns that may be spread across multiple streams of input data. One of the main components of CERA is an intuitive event pattern language that simplifies what would otherwise be the complex, difficult tasks of creating logical descriptions of combinations of temporal events and defining rules for combining information from different sources over time. In this language, recognition patterns are defined in simple, declarative statements that combine point events from given input streams with those from other streams, using conjunction, disjunction, and negation. Patterns can be built on one another recursively to describe very rich, temporally extended combinations of events. Thereafter, a run-time matching algorithm in CERA efficiently matches these patterns against input data and signals when patterns are recognized. CERA can be used to monitor complex systems and to signal operators or initiate corrective actions when anomalous conditions are recognized. CERA can be run as a stand-alone monitoring system, or it can be integrated into a larger system to automatically trigger responses to changing environments or problematic situations.

Electrophysiology of blunted emotional bias in psychopathic personality.

PubMed

Carolan, Patrick L; Jaspers-Fayer, Fern; Asmaro, Deyar T; Douglas, Kevin S; Liotti, Mario

2014-01-01

Diminished emotional capacity is a core characteristic of psychopathic personality. We examined behavioral and electrophysiological differences in attentional bias to emotional material in 34 healthy individuals rated high or low in psychopathic traits using the short form of the Psychopathic Personality Inventory-Revised (18 high-trait, 16 low-trait). While performing an emotional Stroop task, high-trait participants displayed reduced emotional modulation of the late positive potential (LPP, 400-600 ms), and early anterior positivity (EAP, 200-300 ms) amplitudes. Results suggest blunted bias to affective content in psychopathic personality, characterized by diminished early capture to emotional salience (EAP) and dampened cognitive emotional processing (LPP). Copyright © 2013 Society for Psychophysiological Research.

Minimum-Light Spectral Classifications for M-Type Mira Variables

NASA Astrophysics Data System (ADS)

Wing, Robert F.

2015-08-01

Many bright, well-known Mira variables, including most of the 378 stars for which the AAVSO publishes predicted dates of maximum and minimum in its annual Bulletins, have never been spectroscopically observed close to the time of minimum light, and consequently their catalogued ranges in spectral type are often grossly and misleadingly under-represented. In an effort to improve this situation, for the past 12 years I have been using my 6-color system of narrow-band classification photometry to observe Miras predicted to be near minimum light at the times of my biannual observing runs with the CTIO 0.9-m telescope (operated by the SMARTS consortium). The 6-color system measures the 7100 A band of TiO, which serves to classify stars in the interval K4 to M8, and the 1.06 micron band of VO, which is effective for stars of type M8 and later. To date I have made 431 observations of approximately 220 different (and mostly southern) Miras. Examples are shown of the observed 6-color spectra, and the classifications derived from them.

A pilot study of attention bias subtypes: examining their relation to cognitive bias and their change following cognitive behavioral therapy.

PubMed

Calamaras, Martha R; Tone, Erin B; Anderson, Page L

2012-07-01

The present investigation examined (a) whether a clinical sample of individuals with social anxiety disorder (SAD) comprises two distinct groups based on attention bias for social threat (vigilant, avoidant), (b) the relation between attention bias and cognitive bias, specifically estimates of the probability that negative social events will occur (probability bias), and (c) specific changes in attention bias following cognitive behavioral therapy for social anxiety. Participants were 24 individuals (nfemale = 7, nmale = 17; mage = 41) who met diagnostic criteria for SAD and sought treatment for fear of public speaking. Hypotheses were tested using t tests, linear regression analyses, and a mixed design analysis of variance. Results yielded evidence of 2 pretreatment groups (vigilant and avoidant). There was a significant positive correlation between vigilance for (but not avoidance of) threat and probability bias (R = .561, p < .05). After 8 weeks of treatment, the direction of change in attention bias differed between groups, such that the vigilant group became less vigilant and the avoidant group became less avoidant, with the avoidant group showing a significant change in attention bias from pretreatment to posttreatment. These findings provide very preliminary support for the idea that individuals with SAD may differ according to type attention bias, avoidant or vigilant, as these biases changed in different ways following cognitive-behavioral therapy for SAD. Further research is needed to replicate and extend these findings in order to evaluate whether SAD comprises subgroups of attentional biases. © 2012 Wiley Periodicals, Inc.

Interventions for preventing lower limb soft-tissue running injuries.

PubMed

Yeung, Simon S; Yeung, Ella W; Gillespie, Lesley D

2011-07-06

Overuse soft-tissue injuries occur frequently in runners. Stretching exercises, modification of training schedules, and the use of protective devices such as braces and insoles are often advocated for prevention. This is an update of a review first published in 2001. To assess the effects of interventions for preventing lower limb soft-tissue running injuries. We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register (March 2011); The Cochrane Library 2010, Issue 4; MEDLINE (1966 to January 2011); EMBASE (1980 to January 2011); and international trial registries (17 January 2011). Randomised or quasi-randomised trials evaluating interventions to prevent lower limb soft-tissue running injuries. Two authors independently assessed risk of bias (relating to sequence generation, allocation concealment, blinding, incomplete outcome data) and extracted data. Data were adjusted for clustering if necessary and pooled using the fixed-effect model when appropriate. We included 25 trials (30,252 participants). Participants were military recruits (19 trials), runners from the general population (three trials), soccer referees (one trial), and prisoners (two trials). The interventions tested in the included trials fell into four main preventive strategies: exercises, modification of training schedules, use of orthoses, and footwear and socks. All 25 included trials were judged as 'unclear' or 'high' risk of bias for at least one of the four domains listed above.We found no evidence that stretching reduces lower limb soft-tissue injuries (6 trials; 5130 participants; risk ratio [RR] 0.85, 95% confidence interval [95% CI] 0.65 to 1.12). As with all non-significant results, this is compatible with either a reduction or an increase in soft-tissue injuries. We found no evidence to support a training regimen of conditioning exercises to improve strength, flexibility and coordination (one trial; 1020 participants; RR 1.20, 95% CI 0.77 to 1.87).We found no

Not all emotions are created equal: The negativity bias in social-emotional development

PubMed Central

Vaish, Amrisha; Grossmann, Tobias; Woodward, Amanda

2013-01-01

There is ample empirical evidence for an asymmetry in the way that adults use positive versus negative information to make sense of their world; specifically, across an array of psychological situations and tasks, adults display a negativity bias, or the propensity to attend to, learn from, and use negative information far more than positive information. This bias is argued to serve critical evolutionarily adaptive functions, but its developmental presence and ontogenetic emergence have never seriously been considered. Here, we argue for the existence of the negativity bias in early development, evident especially in research on infant social referencing but also in other developmental domains. We discuss ontogenetic mechanisms underlying the emergence of this bias, and explore not only its evolutionary but also its developmental functions and consequences. Throughout, we suggest ways to further examine the negativity bias in infants and older children, and we make testable predictions that would help clarify the nature of the negativity bias during early development. PMID:18444702

Trend in frequency of extreme precipitation events over Ontario from ensembles of multiple GCMs

NASA Astrophysics Data System (ADS)

Deng, Ziwang; Qiu, Xin; Liu, Jinliang; Madras, Neal; Wang, Xiaogang; Zhu, Huaiping

2016-05-01

As one of the most important extreme weather event types, extreme precipitation events have significant impacts on human and natural environment. This study assesses the projected long term trends in frequency of occurrence of extreme precipitation events represented by heavy precipitation days, very heavy precipitation days, very wet days and extreme wet days over Ontario, based on results of 21 CMIP3 GCM runs. To achieve this goal, first, all model data are linearly interpolated onto 682 grid points (0.45° × 0.45°) in Ontario; Next, biases in model daily precipitation amount are corrected with a local intensity scaling method to make the total wet days and total wet day precipitation from each of the GCMs are consistent with that from the climate forecast system reanalysis data, and then the four indices are estimated for each of the 21 GCM runs for 1968-2000, 2046-2065 and 2081-2100. After that, with the assumption that the rate parameter of the Poisson process for the occurrence of extreme precipitation events may vary with time as climate changes, the Poisson regression model which expresses the log rate as a linear function of time is used to detect the trend in frequency of extreme events in the GCMs simulations; Finally, the trends and their uncertainty are estimated. The result shows that in the twenty-first century annual heavy precipitation days, very heavy precipitation days and very wet days and extreme wet days are likely to significantly increase over major parts of Ontario and particularly heavy precipitation days, very wet days are very likely to significantly increase in some sub-regions in eastern Ontario. However, trends of seasonal indices are not significant.

Investigating the Sensitivity of Model Intraseasonal Variability to Minimum Entrainment

NASA Astrophysics Data System (ADS)

Hannah, W. M.; Maloney, E. D.

2008-12-01

Previous studies have shown that using a Relaxed Arakawa-Schubert (RAS) convective parameterization with appropriate convective triggers and assumptions about rain re-evaporation produces realistic intraseasonal variability. RAS represents convection with an ensemble of clouds detraining at different heights, each with different entrainment rate, the highest clouds having the lowest entrainment rates. If tropospheric temperature gradients are weak and boundary layer moist static energy is relatively constant, then by limiting the minimum entrainment rate deep convection is suppressed in the presence of dry tropospheric air. This allows moist static energy to accumulate and be discharged during strong intraseasonal convective events, which is consistent with the discharge/recharge paradigm. This study will examine the sensitivity of intra-seasonal variability to changes in minimum entrainment rate in the NCAR-CAM3 with the RAS scheme. Simulations using several minimum entrainment rate thresholds will be investigated. A frequency-wavenumber analysis will show the improvement of the MJO signal as minimum entrainment rate is increased. The spatial and vertical structure of MJO-like disturbances will be examined, including an analysis of the time evolution of vertical humidity distribution for each simulation. Simulated results will be compared to observed MJO events in NCEP-1 reanalysis and CMAP precipitation.

Evaluation of cool season precipitation event characteristics over the Northeast US in a suite of downscaled climate model hindcasts

NASA Astrophysics Data System (ADS)

Loikith, Paul C.; Waliser, Duane E.; Kim, Jinwon; Ferraro, Robert

2017-08-01

Cool season precipitation event characteristics are evaluated across a suite of downscaled climate models over the northeastern US. Downscaled hindcast simulations are produced by dynamically downscaling the Modern-Era Retrospective Analysis for Research and Applications version 2 (MERRA2) using the National Aeronautics and Space Administration (NASA)-Unified Weather Research and Forecasting (WRF) regional climate model (RCM) and the Goddard Earth Observing System Model, Version 5 (GEOS-5) global climate model. NU-WRF RCM simulations are produced at 24, 12, and 4-km horizontal resolutions using a range of spectral nudging schemes while the MERRA2 global downscaled run is provided at 12.5-km. All model runs are evaluated using four metrics designed to capture key features of precipitation events: event frequency, event intensity, even total, and event duration. Overall, the downscaling approaches result in a reasonable representation of many of the key features of precipitation events over the region, however considerable biases exist in the magnitude of each metric. Based on this evaluation there is no clear indication that higher resolution simulations result in more realistic results in general, however many small-scale features such as orographic enhancement of precipitation are only captured at higher resolutions suggesting some added value over coarser resolution. While the differences between simulations produced using nudging and no nudging are small, there is some improvement in model fidelity when nudging is introduced, especially at a cutoff wavelength of 600 km compared to 2000 km. Based on the results of this evaluation, dynamical regional downscaling using NU-WRF results in a more realistic representation of precipitation event climatology than the global downscaling of MERRA2 using GEOS-5.

Electronic transport in Thue-Morse gapped graphene superlattice under applied bias

NASA Astrophysics Data System (ADS)

Wang, Mingjing; Zhang, Hongmei; Liu, De

2018-04-01

We investigate theoretically the electronic transport properties of Thue-Morse gapped graphene superlattice under an applied electric field. The results indicate that the combined effect of the band gap and the applied bias breaks the angular symmetry of the transmission coefficient. The zero-averaged wave-number gap can be greatly modulated by the band gap and the applied bias, but its position is robust against change of the band gap. Moreover, the conductance and the Fano factor are strongly dependent not only on the Fermi energy but also on the band gap and the applied bias. In the vicinity of the new Dirac point, the minimum value of the conductance obviously decreases and the Fano factor gradually forms a Poissonian value plateau with increasing of the band gap.

Negativity Bias in Dangerous Drivers

PubMed Central

Chai, Jing; Qu, Weina; Sun, Xianghong; Zhang, Kan; Ge, Yan

2016-01-01

The behavioral and cognitive characteristics of dangerous drivers differ significantly from those of safe drivers. However, differences in emotional information processing have seldom been investigated. Previous studies have revealed that drivers with higher anger/anxiety trait scores are more likely to be involved in crashes and that individuals with higher anger traits exhibit stronger negativity biases when processing emotions compared with control groups. However, researchers have not explored the relationship between emotional information processing and driving behavior. In this study, we examined the emotional information processing differences between dangerous drivers and safe drivers. Thirty-eight non-professional drivers were divided into two groups according to the penalty points that they had accrued for traffic violations: 15 drivers with 6 or more points were included in the dangerous driver group, and 23 drivers with 3 or fewer points were included in the safe driver group. The emotional Stroop task was used to measure negativity biases, and both behavioral and electroencephalograph data were recorded. The behavioral results revealed stronger negativity biases in the dangerous drivers than in the safe drivers. The bias score was correlated with self-reported dangerous driving behavior. Drivers with strong negativity biases reported having been involved in mores crashes compared with the less-biased drivers. The event-related potentials (ERPs) revealed that the dangerous drivers exhibited reduced P3 components when responding to negative stimuli, suggesting decreased inhibitory control of information that is task-irrelevant but emotionally salient. The influence of negativity bias provides one possible explanation of the effects of individual differences on dangerous driving behavior and traffic crashes. PMID:26765225

Predictors of early stable symptomatic remission after an exacerbation of schizophrenia: the significance of symptoms, neuropsychological performance and cognitive biases.

PubMed

Andreou, Christina; Roesch-Ely, Daniela; Veckenstedt, Ruth; Bohn, Francesca; Aghotor, Julia; Köther, Ulf; Pfueller, Ute; Moritz, Steffen

2013-12-30

Neuropsychological deficits and severity of initial psychopathology have been repeatedly associated with poor symptomatic outcomes in schizophrenia. The role of higher-order cognitive biases on symptomatic outcomes of the disorder has not yet been investigated. The present study aimed to assess the contribution of cognitive biases, psychopathology and neuropsychological deficits on the probability of achieving early symptomatic remission after a psychotic episode in patients with schizophrenia. Participants were 79 patients with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder undergoing an acute psychotic episode, and 25 healthy controls. According to psychopathology assessments, patients were split into those who had achieved remission after an average follow-up interval of 7 months, and those who had not (NR). Patients who achieved remission exhibited higher premorbid IQ and better performance on the TMT-B, as well as lower baseline positive, disorganized and distress symptoms than NR patients. TMT-B performance and positive symptoms at baseline were the best predictors of remission. Cognitive biases and negative symptoms were not associated with later remission. The findings highlight the significance of initial symptom severity for at least short-term symptomatic outcomes and, thus, the importance of adequate symptomatic treatment and prevention of psychotic outbreaks in patients. © 2013 Elsevier Ireland Ltd. All rights reserved.

PEST reduces bias in forced choice psychophysics.

PubMed

Taylor, M M; Forbes, S M; Creelman, C D

1983-11-01

Observers performed several different detection tasks using both the PEST adaptive psychophysical procedure and a fixed-level (method of constant stimuli) psychophysical procedure. In two experiments, PEST runs targeted at P (C) = 0.80 were immediately followed by fixed-level detection runs presented at the difficulty level resulting from the PEST run. The fixed-level runs yielded P (C) about 0.75. During the fixed-level runs, the probability of a correct response was greater when the preceding response was correct than when it was wrong. Observers, even highly trained ones, perform in a nonstationary manner. The sequential dependency data can be used to determine a lower bound for the observer's "true" capability when performing optimally; this lower bound is close to the PEST target, and well above the forced choice P (C). The observer's "true" capability is the measure used by most theories of detection performance. A further experiment compared psychometric functions obtained from a set of PEST runs using different targets with those obtained from blocks of fixed-level trials at different levels. PEST results were more stable across observers, performance at all but the highest signal levels was better with PEST, and the PEST psychometric functions had shallower slopes. We hypothesize that PEST permits the observer to keep track of what he is trying to detect, whereas in the fixed-level method performance is disrupted by memory failure. Some recently suggested "more virulent" versions of PEST may be subject to biases similar to those of the fixed-level procedures.(ABSTRACT TRUNCATED AT 250 WORDS)

Ethnicity and gender in late childhood and early adolescence: group identity and awareness of bias.

PubMed

Brown, Christia Spears; Alabi, Basirat O; Huynh, Virginia W; Masten, Carrie L

2011-03-01

The current study examined awareness of gender and ethnic bias and gender and ethnic identity in 350 African American, White/European American, and Latino/Hispanic students (Mage = 11.21 years, SD = 1.59) from the 4th, 6th, and 8th grades of diverse middle and elementary schools. The study collected (a) qualitative data to best capture the types of bias that were most salient to children and (b) daily diaries and individual measures to examine the multiple components of children's gender and ethnic identities. Results revealed ethnic, gender, and grade-level differences in awareness of ethnic and gender bias. Overall, more children were aware of gender bias than ethnic bias. This effect was most pronounced among White/European American youths. Among those in 4th grade, African American and Latino youths were more likely to be aware of ethnic bias than were White/European American youths. Analyses also examined how awareness of bias was related to gender and ethnic identity. For example, children who had a salient and important gender identity, and a devalued ethnic identity, were less likely than other children to be aware of ethnic bias. PsycINFO Database Record (c) 2011 APA, all rights reserved.

Does Carbohydrate Intake During Endurance Running Improve Performance? A Critical Review.

PubMed

Wilson, Patrick B

2016-12-01

Wilson, PB. Does carbohydrate intake during endurance running improve performance? A critical review. J Strength Cond Res 30(12): 3539-3559, 2016-Previous review articles assessing the effects of carbohydrate ingestion during prolonged exercise have not focused on running. Given the popularity of distance running and the widespread use of carbohydrate supplements, this article reviewed the evidence for carbohydrate ingestion during endurance running. The criteria for inclusion were (a) experimental studies reported in English language including a performance task, (b) moderate-to-high intensity exercise >60 minutes (intermittent excluded), and (c) carbohydrate ingestion (mouth rinsing excluded). Thirty studies were identified with 76 women and 505 men. Thirteen of the 17 studies comparing a carbohydrate beverage(s) with water or a placebo found a between-condition performance benefit with carbohydrate, although heterogeneity in protocols precludes clear generalizations about the expected effect sizes. Additional evidence suggests that (a) performance benefits are most likely to occur during events >2 hours, although several studies showed benefits for tasks lasting 90-120 minutes; (b) consuming carbohydrate beverages above ad libitum levels increases gastrointestinal discomfort without improving performance; (c) carbohydrate gels do not influence performance for events lasting 16-21 km; and (d) multiple saccharides may benefit events >2 hours if intake is ≥1.3 g·min Given that most participants were fasted young men, inferences regarding women, adolescents, older runners, and those competing in fed conditions are hampered. Future studies should address these limitations to further elucidate the role of carbohydrate ingestion during endurance running.