AstroCloud, a Cyber-Infrastructure for Astronomy Research: Data Access and Interoperability

NASA Astrophysics Data System (ADS)

Fan, D.; He, B.; Xiao, J.; Li, S.; Li, C.; Cui, C.; Yu, C.; Hong, Z.; Yin, S.; Wang, C.; Cao, Z.; Fan, Y.; Mi, L.; Wan, W.; Wang, J.

2015-09-01

Data access and interoperability module connects the observation proposals, data, virtual machines and software. According to the unique identifier of PI (principal investigator), an email address or an internal ID, data can be collected by PI's proposals, or by the search interfaces, e.g. conesearch. Files associated with the searched results could be easily transported to cloud storages, including the storage with virtual machines, or several commercial platforms like Dropbox. Benefitted from the standards of IVOA (International Observatories Alliance), VOTable formatted searching result could be sent to kinds of VO software. Latter endeavor will try to integrate more data and connect archives and some other astronomical resources.

Software aspects of the Geant4 validation repository

NASA Astrophysics Data System (ADS)

Dotti, Andrea; Wenzel, Hans; Elvira, Daniel; Genser, Krzysztof; Yarba, Julia; Carminati, Federico; Folger, Gunter; Konstantinov, Dmitri; Pokorski, Witold; Ribon, Alberto

2017-10-01

The Geant4, GeantV and GENIE collaborations regularly perform validation and regression tests for simulation results. DoSSiER (Database of Scientific Simulation and Experimental Results) is being developed as a central repository to store the simulation results as well as the experimental data used for validation. DoSSiER is easily accessible via a web application. In addition, a web service allows for programmatic access to the repository to extract records in JSON or XML exchange formats. In this article, we describe the functionality and the current status of various components of DoSSiER as well as the technology choices we made.

Software Aspects of the Geant4 Validation Repository

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dotti, Andrea; Wenzel, Hans; Elvira, Daniel

2016-01-01

The Geant4, GeantV and GENIE collaborations regularly perform validation and regression tests for simulation results. DoSSiER (Database of Scientic Simulation and Experimental Results) is being developed as a central repository to store the simulation results as well as the experimental data used for validation. DoSSiER is easily accessible via a web application. In addition, a web service allows for programmatic access to the repository to extract records in JSON or XML exchange formats. In this article, we describe the functionality and the current status of various components of DoSSiER as well as the technology choices we made.

DoSSiER: Database of scientific simulation and experimental results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wenzel, Hans; Yarba, Julia; Genser, Krzystof

The Geant4, GeantV and GENIE collaborations regularly perform validation and regression tests for simulation results. DoSSiER (Database of Scientific Simulation and Experimental Results) is being developed as a central repository to store the simulation results as well as the experimental data used for validation. DoSSiER can be easily accessed via a web application. In addition, a web service allows for programmatic access to the repository to extract records in json or xml exchange formats. In this paper, we describe the functionality and the current status of various components of DoSSiER as well as the technology choices we made.

DoSSiER: Database of scientific simulation and experimental results

DOE PAGES

Wenzel, Hans; Yarba, Julia; Genser, Krzystof; ...

2016-08-01

The Geant4, GeantV and GENIE collaborations regularly perform validation and regression tests for simulation results. DoSSiER (Database of Scientific Simulation and Experimental Results) is being developed as a central repository to store the simulation results as well as the experimental data used for validation. DoSSiER can be easily accessed via a web application. In addition, a web service allows for programmatic access to the repository to extract records in json or xml exchange formats. In this paper, we describe the functionality and the current status of various components of DoSSiER as well as the technology choices we made.

Format guidelines to make them vivid, intuitive, and visual: use simple formatting rules to optimize usability and accessibility of clinical practice guidelines.

PubMed

Versloot, Judith; Grudniewicz, Agnes; Chatterjee, Ananda; Hayden, Leigh; Kastner, Monika; Bhattacharyya, Onil

2015-06-01

We present simple formatting rules derived from an extensive literature review that can improve the format of clinical practice guidelines (CPGs), and potentially increase the likelihood of being used. We recently conducted a review of the literature from medicine, psychology, design, and human factors engineering on characteristics of guidelines that are associated with their use in practice, covering both the creation and communication of content. The formatting rules described in this article are derived from that review. The formatting rules are grouped into three categories that can be easily applied to CPGs: first, Vivid: make it stand out; second, Intuitive: match it to the audience's expectations, and third, Visual: use alternatives to text. We highlight rules supported by our broad literature review and provide specific 'how to' recommendations for individuals and groups developing evidence-based materials for clinicians. The way text documents are formatted influences their accessibility and usability. Optimizing the formatting of CPGs is a relatively inexpensive intervention and can be used to facilitate the dissemination of evidence in healthcare. Applying simple formatting principles to make documents more vivid, intuitive, and visual is a practical approach that has the potential to influence the usability of guidelines and to influence the extent to which guidelines are read, remembered, and used in practice.

Design and Implementation of an Environmental Mercury Database for Northeastern North America

NASA Astrophysics Data System (ADS)

Clair, T. A.; Evers, D.; Smith, T.; Goodale, W.; Bernier, M.

2002-12-01

An important issue faced when attempting to interpret geochemical variability studies across large regions, is the accumulation, access and consistent display of data from a large number of sources. We were given the opportunity to provide a regional assessment of mercury distribution in surface waters, sediments, invertebrates, fish, and birds in a region extending from New York State to the Island of Newfoundland. We received over 20 individual databases from State, Provincial, and Federal governments, as well as university researchers from both Canada and the United States. These databases came in a variety of formats and sizes. Our challenge was to find a way of accumulating and presenting the large amounts of acquired data, in a consistent, easily accessible fashion, which could then be more easily interpreted. Moreover, the database had to be portable and easily distributable to the large number of study participants. We developed a static database structure using a web-based approach which we were then able to mount on a server which was accessible to all project participants. The site also contained all the necessary documentation related to the data, its acquisition, as well as the methods used in its analysis and interpretation. We then copied the complete web site on CDROM's which we then distributed to all project participants, funding agencies, and other interested parties. The CDROM formed a permanent record of the project and was issued ISSN and ISBN numbers so that the information remained accessible to researchers in perpetuity. Here we present an overview of the CDROM and data structures, of the information accumulated over the first year of the study, and initial interpretation of the results.

Simplified stratigraphic cross sections of the Eocene Green River Formation in the Piceance Basin, northwestern Colorado

USGS Publications Warehouse

Dietrich, John D.; Johnson, Ronald C.

2013-01-01

Thirteen stratigraphic cross sections of the Eocene Green River Formation in the Piceance Basin of northwestern Colorado are presented in this report. Originally published in a much larger and more detailed form by Self and others (2010), they are shown here in simplified, page-size versions that are easily accessed and used for presentation purposes. Modifications to the original versions include the elimination of the detailed lithologic columns and oil-yield histograms from Fischer assay data and the addition of ground-surface lines to give the depth of the various oil shale units shown on the cross section.

BioPortal: enhanced functionality via new Web services from the National Center for Biomedical Ontology to access and use ontologies in software applications.

PubMed

Whetzel, Patricia L; Noy, Natalya F; Shah, Nigam H; Alexander, Paul R; Nyulas, Csongor; Tudorache, Tania; Musen, Mark A

2011-07-01

The National Center for Biomedical Ontology (NCBO) is one of the National Centers for Biomedical Computing funded under the NIH Roadmap Initiative. Contributing to the national computing infrastructure, NCBO has developed BioPortal, a web portal that provides access to a library of biomedical ontologies and terminologies (http://bioportal.bioontology.org) via the NCBO Web services. BioPortal enables community participation in the evaluation and evolution of ontology content by providing features to add mappings between terms, to add comments linked to specific ontology terms and to provide ontology reviews. The NCBO Web services (http://www.bioontology.org/wiki/index.php/NCBO_REST_services) enable this functionality and provide a uniform mechanism to access ontologies from a variety of knowledge representation formats, such as Web Ontology Language (OWL) and Open Biological and Biomedical Ontologies (OBO) format. The Web services provide multi-layered access to the ontology content, from getting all terms in an ontology to retrieving metadata about a term. Users can easily incorporate the NCBO Web services into software applications to generate semantically aware applications and to facilitate structured data collection.

Supporting in- and off-Hospital Patient Management Using a Web-based Integrated Software Platform.

PubMed

Spyropoulos, Basile; Botsivali, Maria; Tzavaras, Aris; Pierros, Vasileios

2015-01-01

In this paper, a Web-based software platform appropriately designed to support the continuity of health care information and management for both in and out of hospital care is presented. The system has some additional features as it is the formation of continuity of care records and the transmission of referral letters with a semantically annotated web service. The platform's Web-orientation provides significant advantages, allowing for easily accomplished remote access.

Geoscience Information Network (USGIN) Solutions for Interoperable Open Data Access Requirements

NASA Astrophysics Data System (ADS)

Allison, M. L.; Richard, S. M.; Patten, K.

2014-12-01

The geosciences are leading development of free, interoperable open access to data. US Geoscience Information Network (USGIN) is a freely available data integration framework, jointly developed by the USGS and the Association of American State Geologists (AASG), in compliance with international standards and protocols to provide easy discovery, access, and interoperability for geoscience data. USGIN standards include the geologic exchange language 'GeoSciML' (v 3.2 which enables instant interoperability of geologic formation data) which is also the base standard used by the 117-nation OneGeology consortium. The USGIN deployment of NGDS serves as a continent-scale operational demonstration of the expanded OneGeology vision to provide access to all geoscience data worldwide. USGIN is developed to accommodate a variety of applications; for example, the International Renewable Energy Agency streams data live to the Global Atlas of Renewable Energy. Alternatively, users without robust data sharing systems can download and implement a free software packet, "GINstack" to easily deploy web services for exposing data online for discovery and access. The White House Open Data Access Initiative requires all federally funded research projects and federal agencies to make their data publicly accessible in an open source, interoperable format, with metadata. USGIN currently incorporates all aspects of the Initiative as it emphasizes interoperability. The system is successfully deployed as the National Geothermal Data System (NGDS), officially launched at the White House Energy Datapalooza in May, 2014. The USGIN Foundation has been established to ensure this technology continues to be accessible and available.

A Python library for FAIRer access and deposition to the Metabolomics Workbench Data Repository.

PubMed

Smelter, Andrey; Moseley, Hunter N B

2018-01-01

The Metabolomics Workbench Data Repository is a public repository of mass spectrometry and nuclear magnetic resonance data and metadata derived from a wide variety of metabolomics studies. The data and metadata for each study is deposited, stored, and accessed via files in the domain-specific 'mwTab' flat file format. In order to improve the accessibility, reusability, and interoperability of the data and metadata stored in 'mwTab' formatted files, we implemented a Python library and package. This Python package, named 'mwtab', is a parser for the domain-specific 'mwTab' flat file format, which provides facilities for reading, accessing, and writing 'mwTab' formatted files. Furthermore, the package provides facilities to validate both the format and required metadata elements of a given 'mwTab' formatted file. In order to develop the 'mwtab' package we used the official 'mwTab' format specification. We used Git version control along with Python unit-testing framework as well as continuous integration service to run those tests on multiple versions of Python. Package documentation was developed using sphinx documentation generator. The 'mwtab' package provides both Python programmatic library interfaces and command-line interfaces for reading, writing, and validating 'mwTab' formatted files. Data and associated metadata are stored within Python dictionary- and list-based data structures, enabling straightforward, 'pythonic' access and manipulation of data and metadata. Also, the package provides facilities to convert 'mwTab' files into a JSON formatted equivalent, enabling easy reusability of the data by all modern programming languages that implement JSON parsers. The 'mwtab' package implements its metadata validation functionality based on a pre-defined JSON schema that can be easily specialized for specific types of metabolomics studies. The library also provides a command-line interface for interconversion between 'mwTab' and JSONized formats in raw text and a variety of compressed binary file formats. The 'mwtab' package is an easy-to-use Python package that provides FAIRer utilization of the Metabolomics Workbench Data Repository. The source code is freely available on GitHub and via the Python Package Index. Documentation includes a 'User Guide', 'Tutorial', and 'API Reference'. The GitHub repository also provides 'mwtab' package unit-tests via a continuous integration service.

Providing Access and Visualization to Global Cloud Properties from GEO Satellites

NASA Astrophysics Data System (ADS)

Chee, T.; Nguyen, L.; Minnis, P.; Spangenberg, D.; Palikonda, R.; Ayers, J. K.

2015-12-01

Providing public access to cloud macro and microphysical properties is a key concern for the NASA Langley Research Center Cloud and Radiation Group. This work describes a tool and method that allows end users to easily browse and access cloud information that is otherwise difficult to acquire and manipulate. The core of the tool is an application-programming interface that is made available to the public. One goal of the tool is to provide a demonstration to end users so that they can use the dynamically generated imagery as an input into their own work flows for both image generation and cloud product requisition. This project builds upon NASA Langley Cloud and Radiation Group's experience with making real-time and historical satellite cloud product imagery accessible and easily searchable. As we see the increasing use of virtual supply chains that provide additional value at each link there is value in making satellite derived cloud product information available through a simple access method as well as allowing users to browse and view that imagery as they need rather than in a manner most convenient for the data provider. Using the Open Geospatial Consortium's Web Processing Service as our access method, we describe a system that uses a hybrid local and cloud based parallel processing system that can return both satellite imagery and cloud product imagery as well as the binary data used to generate them in multiple formats. The images and cloud products are sourced from multiple satellites and also "merged" datasets created by temporally and spatially matching satellite sensors. Finally, the tool and API allow users to access information that spans the time ranges that our group has information available. In the case of satellite imagery, the temporal range can span the entire lifetime of the sensor.

Increasing global accessibility and understanding of water column sonar data

NASA Astrophysics Data System (ADS)

Wall, C.; Anderson, C.; Mesick, S.; Parsons, A. R.; Boyer, T.; McLean, S. J.

2016-02-01

Active acoustic (sonar) technology is of increasing importance for research examining the water column. NOAA uses water column sonar data to map acoustic properties from the ocean surface to the seafloor - from bubbles to biology to bottom. Scientific echosounders aboard fishery survey vessels are used to estimate biomass, measure fish school morphology, and characterize habitat. These surveys produce large volumes of data that are costly and difficult to maintain due to their size, complexity, and proprietary format that require specific software and extensive knowledge. However, through proper management they can deliver valuable information beyond their original collection purpose. In order to maximize the benefit to the public, the data must be easily discoverable and accessible. Access to ancillary data is also needed for complete environmental context and ecosystem assessment. NOAA's National Centers for Environmental Information, in partnership with NOAA's National Marine Fisheries Service and the University of Colorado, created a national archive for the stewardship and distribution of water column sonar data collected on NOAA and academic vessels. A web-based access page allows users to query the metadata and access the raw sonar data. Visualization products being developed allow researchers and the public to understand the quality and content of large volumes of archived data more easily. Such products transform the complex data into a digestible image or graphic and are highly valuable for a broad audience of varying backgrounds. Concurrently collected oceanographic data and bathymetric data are being integrated into the data access web page to provide an ecosystem-wide understanding of the area ensonified. Benefits of the archive include global access to an unprecedented nationwide dataset and the increased potential for researchers to address cross-cutting scientific questions to advance the field of marine ecosystem acoustics.

Catalog Descriptions Using VOTable Files

NASA Astrophysics Data System (ADS)

Thompson, R.; Levay, K.; Kimball, T.; White, R.

2008-08-01

Additional information is frequently required to describe database table contents and make it understandable to users. For this reason, the Multimission Archive at Space Telescope (MAST) creates Òdescription filesÓ for each table/catalog. After trying various XML and CSV formats, we finally chose VOTable. These files are easy to update via an HTML form, easily read using an XML parser such as (in our case) the PHP5 SimpleXML extension, and have found multiple uses in our data access/retrieval process.

Acoustical Techniques/Designs Investigated During the Southeast Asia Conflict 1966-1972

DTIC Science & Technology

1981-01-21

the inbuoy processor above, the three sensor channels, two directional and one omni, are multi - plexed together and via the RF link transmitted back to...width at the 10 db dco;.n points and mnximtum side lobe level of -15 db) requires at least six’ elements in the line. At a geometric wean frequency of...presentation provides the data to the operator in the most accessible format. The vehicle descriptors are easily extracted with the aid of multi -point

Converting Topographic Maps into Digital Form to Aid in Archeological Research in the Peten, Guatemala

NASA Technical Reports Server (NTRS)

Aldrich, Serena R.

1999-01-01

The purpose of my project was to convert a topographical map into digital form so that the data can be manipulated and easily accessed in the field. With the data in this particular format, Dr. Sever and his colleagues can highlight the specific features of the landscape that they require for their research of the ancient Mayan civilization. Digital elevation models (DEMs) can also be created from the digitized contour features adding another dimension to their research.

Kinetics and mechanical stability of the fibril state control fibril formation time of polypeptide chains: A computational study

NASA Astrophysics Data System (ADS)

Kouza, Maksim; Co, Nguyen Truong; Li, Mai Suan; Kmiecik, Sebastian; Kolinski, Andrzej; Kloczkowski, Andrzej; Buhimschi, Irina Alexandra

2018-06-01

Fibril formation resulting from protein misfolding and aggregation is a hallmark of several neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Despite much progress in the understanding of the protein aggregation process, the factors governing fibril formation rates and fibril stability have not been fully understood. Using lattice models, we have shown that the fibril formation time is controlled by the kinetic stability of the fibril state but not by its energy. Having performed all-atom explicit solvent molecular dynamics simulations with the GROMOS43a1 force field for full-length amyloid beta peptides Aβ40 and Aβ42 and truncated peptides, we demonstrated that kinetic stability can be accessed via mechanical stability in such a way that the higher the mechanical stability or the kinetic stability, the faster the fibril formation. This result opens up a new way for predicting fibril formation rates based on mechanical stability that may be easily estimated by steered molecular dynamics.

MDAnalysis: a toolkit for the analysis of molecular dynamics simulations.

PubMed

Michaud-Agrawal, Naveen; Denning, Elizabeth J; Woolf, Thomas B; Beckstein, Oliver

2011-07-30

MDAnalysis is an object-oriented library for structural and temporal analysis of molecular dynamics (MD) simulation trajectories and individual protein structures. It is written in the Python language with some performance-critical code in C. It uses the powerful NumPy package to expose trajectory data as fast and efficient NumPy arrays. It has been tested on systems of millions of particles. Many common file formats of simulation packages including CHARMM, Gromacs, Amber, and NAMD and the Protein Data Bank format can be read and written. Atoms can be selected with a syntax similar to CHARMM's powerful selection commands. MDAnalysis enables both novice and experienced programmers to rapidly write their own analytical tools and access data stored in trajectories in an easily accessible manner that facilitates interactive explorative analysis. MDAnalysis has been tested on and works for most Unix-based platforms such as Linux and Mac OS X. It is freely available under the GNU General Public License from http://mdanalysis.googlecode.com. Copyright © 2011 Wiley Periodicals, Inc.

Integrated Management and Visualization of Electronic Tag Data with Tagbase

PubMed Central

Lam, Chi Hin; Tsontos, Vardis M.

2011-01-01

Electronic tags have been used widely for more than a decade in studies of diverse marine species. However, despite significant investment in tagging programs and hardware, data management aspects have received insufficient attention, leaving researchers without a comprehensive toolset to manage their data easily. The growing volume of these data holdings, the large diversity of tag types and data formats, and the general lack of data management resources are not only complicating integration and synthesis of electronic tagging data in support of resource management applications but potentially threatening the integrity and longer-term access to these valuable datasets. To address this critical gap, Tagbase has been developed as a well-rounded, yet accessible data management solution for electronic tagging applications. It is based on a unified relational model that accommodates a suite of manufacturer tag data formats in addition to deployment metadata and reprocessed geopositions. Tagbase includes an integrated set of tools for importing tag datasets into the system effortlessly, and provides reporting utilities to interactively view standard outputs in graphical and tabular form. Data from the system can also be easily exported or dynamically coupled to GIS and other analysis packages. Tagbase is scalable and has been ported to a range of database management systems to support the needs of the tagging community, from individual investigators to large scale tagging programs. Tagbase represents a mature initiative with users at several institutions involved in marine electronic tagging research. PMID:21750734

ThermoBuild: Online Method Made Available for Accessing NASA Glenn Thermodynamic Data

NASA Technical Reports Server (NTRS)

McBride, Bonnie; Zehe, Michael J.

2004-01-01

The new Web site program "ThermoBuild" allows users to easily access and use the NASA Glenn Thermodynamic Database of over 2000 solid, liquid, and gaseous species. A convenient periodic table allows users to "build" the molecules of interest and designate the temperature range over which thermodynamic functions are to be displayed. ThermoBuild also allows users to build custom databases for use with NASA's Chemical Equilibrium with Applications (CEA) program or other programs that require the NASA format for thermodynamic properties. The NASA Glenn Research Center has long been a leader in the compilation and dissemination of up-to-date thermodynamic data, primarily for use with the NASA CEA program, but increasingly for use with other computer programs.

Web service activities at the IRIS DMC to support federated and multidisciplinary access

NASA Astrophysics Data System (ADS)

Trabant, Chad; Ahern, Timothy K.

2013-04-01

At the IRIS Data Management Center (DMC) we have developed a suite of web service interfaces to access our large archive of, primarily seismological, time series data and related metadata. The goals of these web services include providing: a) next-generation and easily used access interfaces for our current users, b) access to data holdings in a form usable for non-seismologists, c) programmatic access to facilitate integration into data processing workflows and d) a foundation for participation in federated data discovery and access systems. To support our current users, our services provide access to the raw time series data and metadata or conversions of the raw data to commonly used formats. Our services also support simple, on-the-fly signal processing options that are common first steps in many workflows. Additionally, high-level data products derived from raw data are available via service interfaces. To support data access by researchers unfamiliar with seismic data we offer conversion of the data to broadly usable formats (e.g. ASCII text) and data processing to convert the data to Earth units. By their very nature, web services are programmatic interfaces. Combined with ubiquitous support for web technologies in programming & scripting languages and support in many computing environments, web services are very well suited for integrating data access into data processing workflows. As programmatic interfaces that can return data in both discipline-specific and broadly usable formats, our services are also well suited for participation in federated and brokered systems either specific to seismology or multidisciplinary. Working within the International Federation of Digital Seismograph Networks, the DMC collaborated on the specification of standardized web service interfaces for use at any seismological data center. These data access interfaces, when supported by multiple data centers, will form a foundation on which to build discovery and access mechanisms for data sets spanning multiple centers. To promote the adoption of these standardized services the DMC has developed portable implementations of the software needed to host these interfaces, minimizing the work required at each data center. Within the COOPEUS project framework, the DMC is working with EU partners to install web services implementations at multiple data centers in Europe.

Space environment data storage and access: lessons learned and recommendations for the future

NASA Astrophysics Data System (ADS)

Evans, Hugh; Heynderickx, Daniel

2012-07-01

With the ever increasing volume of space environment data available at present and planned for the near future, the demands on data storage and access methods are increasing as well. In addition, continued access to historical, archived data remains crucial. On the basis of many years of experience, the authors identify the following issues as important for continued and efficient handling of datasets now and in the future: The huge data volumes currently or very soon avaiable from a number of space missions will limi direct Internet download access to even relatively short epoch ranges of data. Therefore, data providers should establish or extend standardised data (post-) processing services so that only data query results should be downloaded. Although a single standardised data format will in all likelihood remain utopia, data providers should at least include extensive metadata with their data products, according to established standards and practices (e.g. ISTP, SPASE). Standardisation of (sets of) metadata greatly facilitates data mining and querying. The use of SQL database storage should be considered instead of, or in parallel with, classic storage of data files. The use of SQL does away with having to handle file parsing and processing, while at the same time standard access protocols can be used to (remotely) connect to such data repositories. Many data holdings are still lacking in extensive descriptions of data provenance (e.g. instrument description), content and format. Unfortunately, detailed data information is usually rejected by scientific and technical journals. Re-processing of historical archived datasets into modern formats, making them easily available and usable, is urgently required, as knowledge is being lost. A global data directory has still not been achieved; policy makers should enforce stricter rules for "broadcasting" dataset information.

World-Wide Standardized Seismograph Network: a data users guide

USGS Publications Warehouse

Peterson, Jon R.; Hutt, Charles R.

2014-01-01

The purpose of this report, which is based on an unpublished draft prepared in the 1970s, is to provide seismologists with the information they may need to use the WWSSN data set as it becomes available in a more easily accessible and convenient format on the Internet. The report includes a description of the WWSSN network, station facilities, operations and instrumentation, a derivation of the instrument transfer functions, tables of transfer functions, a description of calibration techniques, and a description of a method used to determine important instrument constants using recorded calibration data.

PyParse: a semiautomated system for scoring spoken recall data.

PubMed

Solway, Alec; Geller, Aaron S; Sederberg, Per B; Kahana, Michael J

2010-02-01

Studies of human memory often generate data on the sequence and timing of recalled items, but scoring such data using conventional methods is difficult or impossible. We describe a Python-based semiautomated system that greatly simplifies this task. This software, called PyParse, can easily be used in conjunction with many common experiment authoring systems. Scored data is output in a simple ASCII format and can be accessed with the programming language of choice, allowing for the identification of features such as correct responses, prior-list intrusions, extra-list intrusions, and repetitions.

Process for preparing chemically modified micas for removal of cesium salts from aqueous solution

DOEpatents

Yates, Stephen Frederic; DeFilippi, Irene; Gaita, Romulus; Clearfield, Abraham; Bortun, Lyudmila; Bortun, Anatoly

2000-09-05

A chemically modified mica composite formed by heating a trioctahedral mica in an aqueous solution of sodium chloride having a concentration of at least 1 mole/liter at a temperature greater than 180 degrees Centigrade for at least 20 hours, thereby replacing exchangeable ions in the mica with sodium. Formation is accomplished at temperatures and pressures which are easily accessed by industrial equipment. The reagent employed is inexpensive and non-hazardous, and generates a precipitate which is readily separated from the modified mica.

MR-CDF: Managing multi-resolution scientific data

NASA Technical Reports Server (NTRS)

Salem, Kenneth

1993-01-01

MR-CDF is a system for managing multi-resolution scientific data sets. It is an extension of the popular CDF (Common Data Format) system. MR-CDF provides a simple functional interface to client programs for storage and retrieval of data. Data is stored so that low resolution versions of the data can be provided quickly. Higher resolutions are also available, but not as quickly. By managing data with MR-CDF, an application can be relieved of the low-level details of data management, and can easily trade data resolution for improved access time.

A fast and efficient python library for interfacing with the Biological Magnetic Resonance Data Bank.

PubMed

Smelter, Andrey; Astra, Morgan; Moseley, Hunter N B

2017-03-17

The Biological Magnetic Resonance Data Bank (BMRB) is a public repository of Nuclear Magnetic Resonance (NMR) spectroscopic data of biological macromolecules. It is an important resource for many researchers using NMR to study structural, biophysical, and biochemical properties of biological macromolecules. It is primarily maintained and accessed in a flat file ASCII format known as NMR-STAR. While the format is human readable, the size of most BMRB entries makes computer readability and explicit representation a practical requirement for almost any rigorous systematic analysis. To aid in the use of this public resource, we have developed a package called nmrstarlib in the popular open-source programming language Python. The nmrstarlib's implementation is very efficient, both in design and execution. The library has facilities for reading and writing both NMR-STAR version 2.1 and 3.1 formatted files, parsing them into usable Python dictionary- and list-based data structures, making access and manipulation of the experimental data very natural within Python programs (i.e. "saveframe" and "loop" records represented as individual Python dictionary data structures). Another major advantage of this design is that data stored in original NMR-STAR can be easily converted into its equivalent JavaScript Object Notation (JSON) format, a lightweight data interchange format, facilitating data access and manipulation using Python and any other programming language that implements a JSON parser/generator (i.e., all popular programming languages). We have also developed tools to visualize assigned chemical shift values and to convert between NMR-STAR and JSONized NMR-STAR formatted files. Full API Reference Documentation, User Guide and Tutorial with code examples are also available. We have tested this new library on all current BMRB entries: 100% of all entries are parsed without any errors for both NMR-STAR version 2.1 and version 3.1 formatted files. We also compared our software to three currently available Python libraries for parsing NMR-STAR formatted files: PyStarLib, NMRPyStar, and PyNMRSTAR. The nmrstarlib package is a simple, fast, and efficient library for accessing data from the BMRB. The library provides an intuitive dictionary-based interface with which Python programs can read, edit, and write NMR-STAR formatted files and their equivalent JSONized NMR-STAR files. The nmrstarlib package can be used as a library for accessing and manipulating data stored in NMR-STAR files and as a command-line tool to convert from NMR-STAR file format into its equivalent JSON file format and vice versa, and to visualize chemical shift values. Furthermore, the nmrstarlib implementation provides a guide for effectively JSONizing other older scientific formats, improving the FAIRness of data in these formats.

An innovative approach to capability-based emergency operations planning

PubMed Central

Keim, Mark E

2013-01-01

This paper describes the innovative use information technology for assisting disaster planners with an easily-accessible method for writing and improving evidence-based emergency operations plans. This process is used to identify all key objectives of the emergency response according to capabilities of the institution, community or society. The approach then uses a standardized, objective-based format, along with a consensus-based method for drafting capability-based operational-level plans. This information is then integrated within a relational database to allow for ease of access and enhanced functionality to search, sort and filter and emergency operations plan according to user need and technological capacity. This integrated approach is offered as an effective option for integrating best practices of planning with the efficiency, scalability and flexibility of modern information and communication technology. PMID:28228987

An innovative approach to capability-based emergency operations planning.

PubMed

Keim, Mark E

2013-01-01

This paper describes the innovative use information technology for assisting disaster planners with an easily-accessible method for writing and improving evidence-based emergency operations plans. This process is used to identify all key objectives of the emergency response according to capabilities of the institution, community or society. The approach then uses a standardized, objective-based format, along with a consensus-based method for drafting capability-based operational-level plans. This information is then integrated within a relational database to allow for ease of access and enhanced functionality to search, sort and filter and emergency operations plan according to user need and technological capacity. This integrated approach is offered as an effective option for integrating best practices of planning with the efficiency, scalability and flexibility of modern information and communication technology.

Long Duration Exposure Facility Mini-Data Base User`s Guide: Macintosh version. (Diskette)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bohnhoff-Hlavacek, G.; Pippin, H.G.; Dursch, H.W.

1995-04-01

One of the objectives of the LDEF Special Investigation Group (SIG) was to develop a LDEF data base that identifies the experiment objectives and hardware flown, summarizes results and conclusions, and provides a system analysis overview, including spacecraft design guidelines and space environmental effects. Compiling the information into an easily accessible data base format, and making it available to the space community was a major task accomplished by the System and Materials SIG effort beginning in 1981. Included in this document is a short user`s manual for the LDEF Mini-Data Bases. The user`s manual contains pertinent examples from the datamore » base on specifically how to access and work with the LDEF information. Accompanying this document are the mini-data bases on disk.« less

Design reflowable digital book template

NASA Astrophysics Data System (ADS)

Prasetya, Didik Dwi; Widiyaningtyas, Triyanna; Arifin, M. Zainal; Wahyu Sakti G., I.

2017-09-01

Electronic books (e-books or digital books) increasingly in demand and continue to grow in the form of future books. One of the standard format electronic books that potential is EPUB (electronic publication) published by the International Digital Publishing Forum (IDPF). This digital book has major advantages are able to provide interactive and reflowable content, which are not found in another book format, such as PDF. Reflowable content allows the book can be accessed through a variety of reader device, like desktop and mobile with a fit and comfort view. However, because the generating process of an EPUB digital book is not as easy a PDF, so this format is less popular. Therefore, in order to help overcome the existing problems, this paper develops digital reflowable text book templates to support electronic learning, especially in Indonesia. This template can be used by anyone to produce a standard digital book quickly and easily without requiring additional specialized knowledge.

Lightweight Object Oriented Structure analysis: Tools for building Tools to Analyze Molecular Dynamics Simulations

PubMed Central

Romo, Tod D.; Leioatts, Nicholas; Grossfield, Alan

2014-01-01

LOOS (Lightweight Object-Oriented Structure-analysis) is a C++ library designed to facilitate making novel tools for analyzing molecular dynamics simulations by abstracting out the repetitive tasks, allowing developers to focus on the scientifically relevant part of the problem. LOOS supports input using the native file formats of most common biomolecular simulation packages, including CHARMM, NAMD, Amber, Tinker, and Gromacs. A dynamic atom selection language based on the C expression syntax is included and is easily accessible to the tool-writer. In addition, LOOS is bundled with over 120 pre-built tools, including suites of tools for analyzing simulation convergence, 3D histograms, and elastic network models. Through modern C++ design, LOOS is both simple to develop with (requiring knowledge of only 4 core classes and a few utility functions) and is easily extensible. A python interface to the core classes is also provided, further facilitating tool development. PMID:25327784

Lightweight object oriented structure analysis: tools for building tools to analyze molecular dynamics simulations.

PubMed

Romo, Tod D; Leioatts, Nicholas; Grossfield, Alan

2014-12-15

LOOS (Lightweight Object Oriented Structure-analysis) is a C++ library designed to facilitate making novel tools for analyzing molecular dynamics simulations by abstracting out the repetitive tasks, allowing developers to focus on the scientifically relevant part of the problem. LOOS supports input using the native file formats of most common biomolecular simulation packages, including CHARMM, NAMD, Amber, Tinker, and Gromacs. A dynamic atom selection language based on the C expression syntax is included and is easily accessible to the tool-writer. In addition, LOOS is bundled with over 140 prebuilt tools, including suites of tools for analyzing simulation convergence, three-dimensional histograms, and elastic network models. Through modern C++ design, LOOS is both simple to develop with (requiring knowledge of only four core classes and a few utility functions) and is easily extensible. A python interface to the core classes is also provided, further facilitating tool development. © 2014 Wiley Periodicals, Inc.

Improving Access to Precipitation Data for GIS Users: Designing for Ease of Use

NASA Technical Reports Server (NTRS)

Stocker, Erich F.; Kelley, Owen A.

2007-01-01

The Global Precipitation Measurement Mission (GPM) is a NASA/JAXA led international mission to configure a constellation of space-based radiometers to monitor precipitation over the globe. The GPM goal of making global 3-hour precipitation products available in near real-time will make such global products more useful to a broader community of modelers and Geographic Information Systems (GIS) users than is currently the case with remote sensed precipitation products. Based on the existing interest to make Tropical Rainfall Measuring Mission (TRMM) data available to a growing community of GIS users as well as what will certainly be an expanded community during the GPM era, it is clear that data systems must make a greater effort to provide data in formats easily used by GIS. We describe precipitation GIS products being developed for TRMM data. These products will serve as prototypes for production efforts during the GPM era. We describe efforts to convert TRMM precipitation data to GeoTIFF, Shapefile, and ASCII grid. Clearly, our goal is to format GPM data so that it can be easily used within GIS applications. We desire feedback on these efforts and any additions or direction changes that should be undertaken by the data system.

Simplified Metadata Curation via the Metadata Management Tool

NASA Astrophysics Data System (ADS)

Shum, D.; Pilone, D.

2015-12-01

The Metadata Management Tool (MMT) is the newest capability developed as part of NASA Earth Observing System Data and Information System's (EOSDIS) efforts to simplify metadata creation and improve metadata quality. The MMT was developed via an agile methodology, taking into account inputs from GCMD's science coordinators and other end-users. In its initial release, the MMT uses the Unified Metadata Model for Collections (UMM-C) to allow metadata providers to easily create and update collection records in the ISO-19115 format. Through a simplified UI experience, metadata curators can create and edit collections without full knowledge of the NASA Best Practices implementation of ISO-19115 format, while still generating compliant metadata. More experienced users are also able to access raw metadata to build more complex records as needed. In future releases, the MMT will build upon recent work done in the community to assess metadata quality and compliance with a variety of standards through application of metadata rubrics. The tool will provide users with clear guidance as to how to easily change their metadata in order to improve their quality and compliance. Through these features, the MMT allows data providers to create and maintain compliant and high quality metadata in a short amount of time.

TADPLOT program, version 2.0: User's guide

NASA Technical Reports Server (NTRS)

Hammond, Dana P.

1991-01-01

The TADPLOT Program, Version 2.0 is described. The TADPLOT program is a software package coordinated by a single, easy-to-use interface, enabling the researcher to access several standard file formats, selectively collect specific subsets of data, and create full-featured publication and viewgraph quality plots. The user-interface was designed to be independent from any file format, yet provide capabilities to accommodate highly specialized data queries. Integrated with an applications software network, data can be assessed, collected, and viewed quickly and easily. Since the commands are data independent, subsequent modifications to the file format will be transparent, while additional file formats can be integrated with minimal impact on the user-interface. The graphical capabilities are independent of the method of data collection; thus, the data specification and subsequent plotting can be modified and upgraded as separate functional components. The graphics kernel selected adheres to the full functional specifications of the CORE standard. Both interface and postprocessing capabilities are fully integrated into TADPLOT.

Laser-Mechanical Drilling for Geothermal Energy: Low-Contact Drilling Technology to Enable Economical EGS Wells

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2010-01-15

Broad Funding Opportunity Announcement Project: Foro Energy is developing a unique capability and hardware system to transmit high power lasers over long distances via fiber optic cables. This laser power is integrated with a mechanical drilling bit to enable rapid and sustained penetration of hard rock formations too costly to drill with mechanical drilling bits alone. The laser energy that is directed at the rock basically softens the rock, allowing the mechanical bit to more easily remove it. Foro Energy’s laser-assisted drill bits have the potential to be up to 10 times more economical than conventional hard-rock drilling technologies, makingmore » them an effective way to access the U.S. energy resources currently locked under hard rock formations.« less

Treatment of earlobe keloids using the cobalt 60 teletherapy unit.

PubMed

Malaker, Kamal; Zaidi, Mustafa; Franka, Mohamad Rida

2004-06-01

The purpose of this study was to develop an easily accessible technique for the delivery of postoperative radiotherapy for the treatment of earlobe keloids. Forty-seven earlobe keloids were given postoperative radiation using the smallest achievable half field Telecobalt technique. Results showed 41 (87.2%) of treated patients' postoperative scars remained free from recurrent keloid formation. Acute reactions were minimal and patient compliance was excellent. In conclusion, the technique described in this study for the delivery of postoperative radiation to earlobe keloids should be readily available in areas of high prevalence. Results are comparable to previously used radiotherapy techniques.

Facilitating Scientific Collaboration and Education with Easy Access Web Maps Using the AGAP Antarctic Geophysical Data

NASA Astrophysics Data System (ADS)

Abdi, A.

2012-12-01

Science and science education benefit from easy access to data yet often geophysical data sets are large, complex and difficult to share. The difficulty in sharing data and imagery easily inhibits both collaboration and the use of real data in educational applications. The dissemination of data products through web maps serves a very efficient and user-friendly method for students, the public and the science community to gain insights and understanding from data. Few research groups provide direct access to their data, let alone map-based visualizations. By building upon current GIS infrastructure with web mapping technologies, like ArcGIS Server, scientific groups, institutions and agencies can enhance the value of their GIS investments. The advantages of web maps to serve data products are many; existing web-mapping technology allows complex GIS analysis to be shared across the Internet, and can be easily scaled from a few users to millions. This poster highlights the features of an interactive web map developed at the Polar Geophysics Group at the Lamont-Doherty Earth Observatory of Columbia University that provides a visual representation of, and access to, data products that resulted from the group's recently concluded AGAP project (http://pgg.ldeo.columbia.edu). The AGAP project collected more than 120,000 line km of new aerogeophysical data using two Twin Otter aircrafts. Data included ice penetrating radar, magnetometer, gravimeter and laser altimeter measurements. The web map is based upon ArcGIS Viewer for Flex, which is a configurable client application built on the ArcGIS API for Flex that works seamlessly with ArcGIS Server 10. The application can serve a variety of raster and vector file formats through the Data Interoperability for Server, which eliminates data sharing barriers across numerous file formats. The ability of the application to serve large datasets is only hindered by the availability of appropriate hardware. ArcGIS is a proprietary product, but there are a few data portals in the earth sciences that have a map interface using open access products such as MapServer and OpenLayers, the most notable being the NASA IceBridge Data Portal. Indeed, with the widespread availability of web mapping technology, the scientific community should advance towards this direction when disseminating their data.

Effect of Pulse and dc Formation on the Performance of One-Transistor and One-Resistor Resistance Random Access Memory Devices

NASA Astrophysics Data System (ADS)

Liu, Hong-Tao; Yang, Bao-He; Lv, Hang-Bing; Xu, Xiao-Xin; Luo, Qing; Wang, Guo-Ming; Zhang, Mei-Yun; Long, Shi-Bing; Liu, Qi; Liu, Ming

2015-02-01

We investigate the effect of the formation process under pulse and dc modes on the performance of one transistor and one resistor (1T1R) resistance random access memory (RRAM) device. All the devices are operated under the same test conditions, except for the initial formation process with different modes. Based on the statistical results, the high resistance state (HRS) under the dc forming mode shows a lower value with better distribution compared with that under the pulse mode. One of the possible reasons for such a phenomenon originates from different properties of conductive filament (CF) formed in the resistive switching layer under two different modes. For the dc forming mode, the formed filament is thought to be continuous, which is hard to be ruptured, resulting in a lower HRS. However, in the case of pulse forming, the filament is discontinuous where the transport mechanism is governed by hopping. The low resistance state (LRS) can be easily changed by removing a few trapping states from the conducting path. Hence, a higher HRS is thus observed. However, the HRS resistance is highly dependent on the length of the gap opened. A slight variation of the gap length will cause wide dispersion of resistance.

Long Duration Exposure Facility mini-data base user`s guide: IBM-compatible PC computer version. (Diskette)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bohnhoff-Hlavacek, G.; Pippin, G.; Dursch, H.

1995-04-01

One of the objectives of the LDEF Special Investigation Group (SIG) was to develop a LDEF data base that identifies the experiment objectives and hardware flown, summarizes results and conclusions, and provides a system analysis overview which would include spacecraft design guidelines and space environmental effects. Compiling this information into an easily accessible data base format and making it available to the space community was a major task accomplished by the System and Materials SIG effort beginning in 1991. Included in this document is a short user`s manual for the LDEF Mini-Data Bases. The user`s manual contains pertinent examples frommore » the data base on specifically how to access and work with the LDEF information. Accompanying this document are the mini-data bases on disk.« less

Large optical 3D MEMS switches in access networks

NASA Astrophysics Data System (ADS)

Madamopoulos, Nicholas; Kaman, Volkan; Yuan, Shifu; Jerphagnon, Olivier; Helkey, Roger; Bowers, John E.

2007-09-01

Interest is high among residential customers and businesses for advanced, broadband services such as fast Internet access, electronic commerce, video-on-demand, digital broadcasting, teleconferencing and telemedicine. In order to satisfy such growing demand of end-customers, access technologies such as fiber-to-the-home/building (FTTH/B) are increasingly being deployed. Carriers can reduce maintenance costs, minimize technology obsolescence and introduce new services easily by reducing active elements in the fiber access network. However, having a passive optical network (PON) also introduces operational and maintenance challenges. Increased diagnostic monitoring capability of the network becomes a necessity as more and more fibers are provisioned to deliver services to the end-customers. This paper demonstrates the clear advantages that large 3D optical MEMS switches offer in solving these access network problems. The advantages in preventative maintenance, remote monitoring, test and diagnostic capability are highlighted. The low optical insertion loss for all switch optical connections of the switch enables the monitoring, grooming and serving of a large number of PON lines and customers. Furthermore, the 3D MEMS switch is transparent to optical wavelengths and data formats, thus making it easy to incorporate future upgrades, such higher bit rates or DWDM overlay to a PON.

Crosstalk: public cafés as places for knowledge translation concerning health care research.

PubMed

Reimer-Kirkham, Sheryl; Jule, Allyson

2015-01-01

This article explores the use of public cafés as a model for knowledge translation and community engagement. We base our discussion on a public café series organized around the theme of access to health care and held in three neighborhoods in the Lower Mainland of British Columbia, Canada. The cafés were part of the Canadian Institutes of Health Research Café Scientifique program. Our purposes for this series of cafés were threefold: (a) to provide a site of communication to connect research with members of the public, (b) to build a network among participants based on common connections to the local community, and (c) to explore through discussion how gendered and raced perspectives concerning access to health care may influence the lived experiences of Canadians today. We intended to promote an intergroup conversation, based on the assumption that people of First Nations descent, newcomers to Canada (whether through immigration or resettlement), and settlers (such as Euro-Canadians) would all benefit from hearing each other's perspectives on access to health care, as well as presentations by invited academics about their research on access to health care. A form of "crosstalk" emerged in the cafés, mediated by gender and ethnicity, where social differences and geographical distances between various groups were not easily bridged, and yet where opportunity was created for inclusive dialogic spaces. We conclude that knowledge translation is not easily accomplished with the café format, at least not with the type of critical knowledge we were aiming to translate and the depth of engagement we were hoping for. Our experiences highlighted three strategies that facilitate knowledge translation: relationships and shared goals; involvement of policymakers and decision makers; and tending to social relations of power.

Consumer-based technology for distribution of surgical videos for objective evaluation.

PubMed

Gonzalez, Ray; Martinez, Jose M; Lo Menzo, Emanuele; Iglesias, Alberto R; Ro, Charles Y; Madan, Atul K

2012-08-01

The Global Operative Assessment of Laparoscopic Skill (GOALS) is one validated metric utilized to grade laparoscopic skills and has been utilized to score recorded operative videos. To facilitate easier viewing of these recorded videos, we are developing novel techniques to enable surgeons to view these videos. The objective of this study is to determine the feasibility of utilizing widespread current consumer-based technology to assist in distributing appropriate videos for objective evaluation. Videos from residents were recorded via a direct connection from the camera processor via an S-video output via a cable into a hub to connect to a standard laptop computer via a universal serial bus (USB) port. A standard consumer-based video editing program was utilized to capture the video and record in appropriate format. We utilized mp4 format, and depending on the size of the file, the videos were scaled down (compressed), their format changed (using a standard video editing program), or sliced into multiple videos. Standard available consumer-based programs were utilized to convert the video into a more appropriate format for handheld personal digital assistants. In addition, the videos were uploaded to a social networking website and video sharing websites. Recorded cases of laparoscopic cholecystectomy in a porcine model were utilized. Compression was required for all formats. All formats were accessed from home computers, work computers, and iPhones without difficulty. Qualitative analyses by four surgeons demonstrated appropriate quality to grade for these formats. Our preliminary results show promise that, utilizing consumer-based technology, videos can be easily distributed to surgeons to grade via GOALS via various methods. Easy accessibility may help make evaluation of resident videos less complicated and cumbersome.

Parallel collisionless shocks forming in simulations of the LAPD experiment

NASA Astrophysics Data System (ADS)

Weidl, Martin S.; Jenko, Frank; Niemann, Chris; Winske, Dan

2016-10-01

Research on parallel collisionless shocks, most prominently occurring in the Earth's bow shock region, has so far been limited to satellite measurements and simulations. However, the formation of collisionless shocks depends on a wide range of parameters and scales, which can be accessed more easily in a laboratory experiment. Using a kJ-class laser, an ongoing experimental campaign at the Large Plasma Device (LAPD) at UCLA is expected to produce the first laboratory measurements of the formation of a parallel collisionless shock. We present hybrid kinetic/MHD simulations that show how beam instabilities in the background plasma can be driven by ablating carbon ions from a target, causing non-linear density oscillations which develop into a propagating shock front. The free-streaming carbon ions can excite both the resonant right-hand instability and the non-resonant firehose mode. We analyze their respective roles and discuss optimizing their growth rates to speed up the process of shock formation.

Australian general practitioner attitudes to clinical practice guidelines and some implications for translating osteoarthritis care into practice.

PubMed

Basedow, Martin; Runciman, William B; Lipworth, Wendy; Esterman, Adrian

2016-11-01

Clinical practice guidelines (CPGs) have been shown to improve processes of care and health outcomes, but there is often a discrepancy between recommendations for care and clinical practice. This study sought to explore general practitioner (GP) attitudes towards CPGs, in general and specifically for osteoarthritis (OA), with the implications for translating OA care into practice. A self-administered questionnaire was conducted in January 2013 with a sample of 228 GPs in New South Wales and South Australia. Seventy-nine GPs returned questionnaires (response rate 35%). Nearly all GPs considered that CPGs support decision-making in practice (94%) and medical education (92%). Very few respondents regarded CPGs as a threat to clinical autonomy, and most recognised that individual patient circumstances must be taken into account. Shorter CPG formats were preferred over longer and more comprehensive formats, with preferences being evenly divided among respondents for short, 2-3-page summaries, flowcharts or algorithms and single page checklists. GPs considered accessibility to CPGs to be important, and electronic formats were popular. Familiarity and use of The Royal Australian College of General Practitioners OA Guideline was poor, with most respondents either not aware of it (30%; 95% confidence interval (CI) 27 - 41%), had never used it (19%; 95% CI 12 - 29%) or rarely used it (34%; 95% CI 25-45%). If CPGs are to assist with the translation of evidence into practice, they must be easily accessible and in a format that encourages use.

iSpy: a powerful and lightweight event display

NASA Astrophysics Data System (ADS)

Alverson, G.; Eulisse, G.; McCauley, T.; Taylor, L.

2012-12-01

iSpy is a general-purpose event data and detector visualization program that was developed as an event display for the CMS experiment at the LHC and has seen use by the general public and teachers and students in the context of education and outreach. Central to the iSpy design philosophy is ease of installation, use, and extensibility. The application itself uses the open-access packages Qt4 and Open Inventor and is distributed either as a fully-bound executable or a standard installer package: one can simply download and double-click to begin. Mac OSX, Linux, and Windows are supported. iSpy renders the standard 2D, 3D, and tabular views, and the architecture allows for a generic approach to production of new views and projections. iSpy reads and displays data in the ig format: event information is written in compressed JSON format files designed for distribution over a network. This format is easily extensible and makes the iSpy client indifferent to the original input data source. The ig format is the one used for release of approved CMS data to the public.

Common Data Format (CDF) and Coordinated Data Analysis Web (CDAWeb)

NASA Technical Reports Server (NTRS)

Candey, Robert M.

2010-01-01

The Coordinated Data Analysis Web (CDAWeb) data browsing system provides plotting, listing and open access v ia FTP, HTTP, and web services (REST, SOAP, OPeNDAP) for data from mo st NASA Heliophysics missions and is heavily used by the community. C ombining data from many instruments and missions enables broad resear ch analysis and correlation and coordination with other experiments a nd missions. Crucial to its effectiveness is the use of a standard se lf-describing data format, in this case, the Common Data Format (CDF) , also developed at the Space Physics Data facility , and the use of metadata standa rds (easily edited with SKTeditor ). CDAweb is based on a set of IDL routines, CDAWlib . . The CDF project also maintains soft ware and services for translating between many standard formats (CDF. netCDF, HDF, FITS, XML) .

Deciding with the eye: how the visually manipulated accessibility of information in memory influences decision behavior.

PubMed

Platzer, Christine; Bröder, Arndt; Heck, Daniel W

2014-05-01

Decision situations are typically characterized by uncertainty: Individuals do not know the values of different options on a criterion dimension. For example, consumers do not know which is the healthiest of several products. To make a decision, individuals can use information about cues that are probabilistically related to the criterion dimension, such as sugar content or the concentration of natural vitamins. In two experiments, we investigated how the accessibility of cue information in memory affects which decision strategy individuals rely on. The accessibility of cue information was manipulated by means of a newly developed paradigm, the spatial-memory-cueing paradigm, which is based on a combination of the looking-at-nothing phenomenon and the spatial-cueing paradigm. The results indicated that people use different decision strategies, depending on the validity of easily accessible information. If the easily accessible information is valid, people stop information search and decide according to a simple take-the-best heuristic. If, however, information that comes to mind easily has a low predictive validity, people are more likely to integrate all available cue information in a compensatory manner.

OBIS-USA: a data-sharing legacy of the census of marine life

USGS Publications Warehouse

Sedberry, G.R.; Fautin, D.G.; Feldman, M.; Fornwall, M.D.; Goldstein, P.; Guralnick, R.P.

2011-01-01

The United States Geological Survey's Biological Informatics Program hosts OBIS-USA, the US node of the Ocean Biogeographic Information System (OBIS). OBIS-USA gathers, coordinates, applies standard formats to, and makeswidely available data on biological collections in marine waters of the United States and other areas where US investigators have collected data and, in some instances, specimens. OBIS-USA delivers its data to OBIS international, which then delivers its data to the Global Biodiversity Information Facility (GBIF) and other Web portals for marine biodiversity data. OBIS-USA currently has 145 data sets from 36 participants, representing over 6.5 million occurrence records of over 83,000 taxa from more than 888,000 locations. OBIS-USA, a legacy of the decade-long (2001-2010) international collaborative Census of Marine Life enterprise, continues to add data, including those from ongoing Census projects. Among the many challenges in creating OBIS, including OBIS-USA, were developing a community of trust and shared valueamong data providers, and demonstrating to providers the value of making their data accessible to others. Challenges also posed by the diversity of data sets relevant tomarine biodiversity stored on thousands of computers, in a variety of formats, not all widely accessible, have been met in OBIS-USA by implementing a uniform standard and publishing platform that is easily accessible to a broad range of users.

OBIS-USA: a data-sharing legacy of census of marine life

USGS Publications Warehouse

Sedberry, George R.; Fautin, Daphne G.; Feldman, Michael; Fornwall, Mark D.; Goldstein, Phillip; Guralnick, Robert P.

2011-01-01

The United States Geological Survey's Biological Informatics Program hosts OBIS-USA, the US node of the Ocean Biogeographic Information System (OBIS). OBIS-USA gathers, coordinates, applies standard formats to, and makes widely available data on biological collections in marine waters of the United States and other areas where US investigators have collected data and, in some instances, specimens. OBIS-USA delivers its data to OBIS international, which then delivers its data to the Global Biodiversity Information Facility (GBIF) and other Web portals for marine biodiversity data. OBIS-USA currently has 145 data sets from 36 participants, representing over 6.5 million occurrence records of over 83,000 taxa from more than 888,000 locations. OBIS-USA, a legacy of the decade-long (2001–2010) international collaborative Census of Marine Life enterprise, continues to add data, including those from ongoing Census projects. Among the many challenges in creating OBIS, including OBIS-USA, were developing a community of trust and shared value among data providers, and demonstrating to providers the value of making their data accessible to others. Challenges also posed by the diversity of data sets relevant to marine biodiversity stored on thousands of computers, in a variety of formats, not all widely accessible, have been met in OBIS-USA by implementing a uniform standard and publishing platform that is easily accessible to a broad range of users.

An easily accessible carbon material derived from carbonization of polyacrylonitrile ultrathin films: ambipolar transport properties and application in a CMOS-like inverter.

PubMed

Jiao, Fei; Zhang, Fengjiao; Zang, Yaping; Zou, Ye; Di, Chong'an; Xu, Wei; Zhu, Daoben

2014-03-04

Ultrathin carbon films were prepared by carbonization of a solution processed polyacrylonitrile (PAN) film in a moderate temperature range (500-700 °C). The films displayed balanced hole (0.50 cm(2) V(-1) s(-1)) and electron mobilities (0.20 cm(2) V(-1) s(-1)) under ambient conditions. Spectral characterization revealed that the electrical transport is due to the formation of sp(2) hybridized carbon during the carbonization process. A CMOS-like inverter demonstrated the potential application of this material in the area of carbon electronics, considering its processability and low-cost.

Interventional nephrology: Physical examination as a tool for surveillance for the hemodialysis arteriovenous access.

PubMed

Salman, Loay; Beathard, Gerald

2013-07-01

The prospective recognition of stenosis affecting dialysis vascular access and its prospective treatment is important in the management of the hemodialysis patient. Surveillance by physical examination is easily learned, easily performed, quickly done, and economical. In addition, it has a level of accuracy and reliability equivalent to other approaches that require special instrumentation. Physical examination should be part of any education to all hemodialysis care givers. This review presents the basic principles of physical examination of the hemodialysis vascular access and discusses the evidence behind its value.

Hydratools, a MATLAB® based data processing package for Sontek Hydra data

USGS Publications Warehouse

Martini, M.; Lightsom, F.L.; Sherwood, C.R.; Xu, Jie; Lacy, J.R.; Ramsey, A.; Horwitz, R.

2005-01-01

The U.S. Geological Survey (USGS) has developed a set of MATLAB tools to process and convert data collected by Sontek Hydra instruments to netCDF, which is a format used by the USGS to process and archive oceanographic time-series data. The USGS makes high-resolution current measurements within 1.5 meters of the bottom. These data are used in combination with other instrument data from sediment transport studies to develop sediment transport models. Instrument manufacturers provide software which outputs unique binary data formats. Multiple data formats are cumbersome. The USGS solution is to translate data streams into a common data format: netCDF. The Hydratools toolbox is written to create netCDF format files following EPIC conventions, complete with embedded metadata. Data are accepted from both the ADV and the PCADP. The toolbox will detect and remove bad data, substitute other sources of heading and tilt measurements if necessary, apply ambiguity corrections, calculate statistics, return information about data quality, and organize metadata. Standardized processing and archiving makes these data more easily and routinely accessible locally and over the Internet. In addition, documentation of the techniques used in the toolbox provides a baseline reference for others utilizing the data.

ArrayBridge: Interweaving declarative array processing with high-performance computing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xing, Haoyuan; Floratos, Sofoklis; Blanas, Spyros

Scientists are increasingly turning to datacenter-scale computers to produce and analyze massive arrays. Despite decades of database research that extols the virtues of declarative query processing, scientists still write, debug and parallelize imperative HPC kernels even for the most mundane queries. This impedance mismatch has been partly attributed to the cumbersome data loading process; in response, the database community has proposed in situ mechanisms to access data in scientific file formats. Scientists, however, desire more than a passive access method that reads arrays from files. This paper describes ArrayBridge, a bi-directional array view mechanism for scientific file formats, that aimsmore » to make declarative array manipulations interoperable with imperative file-centric analyses. Our prototype implementation of ArrayBridge uses HDF5 as the underlying array storage library and seamlessly integrates into the SciDB open-source array database system. In addition to fast querying over external array objects, ArrayBridge produces arrays in the HDF5 file format just as easily as it can read from it. ArrayBridge also supports time travel queries from imperative kernels through the unmodified HDF5 API, and automatically deduplicates between array versions for space efficiency. Our extensive performance evaluation in NERSC, a large-scale scientific computing facility, shows that ArrayBridge exhibits statistically indistinguishable performance and I/O scalability to the native SciDB storage engine.« less

Designing a data portal for synthesis modeling

NASA Astrophysics Data System (ADS)

Holmes, M. A.

2006-12-01

Processing of field and model data in multi-disciplinary integrated science studies is a vital part of synthesis modeling. Collection and storage techniques for field data vary greatly between the participating scientific disciplines due to the nature of the data being collected, whether it be in situ, remotely sensed, or recorded by automated data logging equipment. Spreadsheets, personal databases, text files and binary files are used in the initial storage and processing of the raw data. In order to be useful to scientists, engineers and modelers the data need to be stored in a format that is easily identifiable, accessible and transparent to a variety of computing environments. The Model Operations and Synthesis (MOAS) database and associated web portal were created to provide such capabilities. The industry standard relational database is comprised of spatial and temporal data tables, shape files and supporting metadata accessible over the network, through a menu driven web-based portal or spatially accessible through ArcSDE connections from the user's local GIS desktop software. A separate server provides public access to spatial data and model output in the form of attributed shape files through an ArcIMS web-based graphical user interface.

Profex: a graphical user interface for the Rietveld refinement program BGMN.

PubMed

Doebelin, Nicola; Kleeberg, Reinhard

2015-10-01

Profex is a graphical user interface for the Rietveld refinement program BGMN . Its interface focuses on preserving BGMN 's powerful and flexible scripting features by giving direct access to BGMN input files. Very efficient workflows for single or batch refinements are achieved by managing refinement control files and structure files, by providing dialogues and shortcuts for many operations, by performing operations in the background, and by providing import filters for CIF and XML crystal structure files. Refinement results can be easily exported for further processing. State-of-the-art graphical export of diffraction patterns to pixel and vector graphics formats allows the creation of publication-quality graphs with minimum effort. Profex reads and converts a variety of proprietary raw data formats and is thus largely instrument independent. Profex and BGMN are available under an open-source license for Windows, Linux and OS X operating systems.

Hydroalumination of Ketenimines and Subsequent Reactions with Heterocumulenes: Synthesis of Unsaturated Amide Derivatives and 1,3-Diimines.

PubMed

Jin, Xing; Willeke, Matthias; Lucchesi, Ralph; Daniliuc, Constantin-Gabriel; Fröhlich, Roland; Wibbeling, Birgit; Uhl, Werner; Würthwein, Ernst-Ulrich

2015-06-19

The series of differently substituted ketenimines 1 was hydroluminated using di-iso-butyl aluminum hydride. For the sterically congested ketenimine 1a, preferred hydroalumination of the C═N-bond was proven by X-ray crystallography (compound 5a). In situ treatment of the hydroaluminated ketenimines 5 with various heterocumulenes like carbodiimides, isocycanates, isothiocyanates and ketenimines as electrophiles and subsequent hydrolytic workup resulted in novel enamine derived amide species in case of N-attack (sterically less hindered ketenimines) under formation of a new C-N-bond or in 1,3-diimines by C-C-bond-formation in case of bulky substituents at the ketenimine-nitrogen atom. Furthermore, domino reactions with more than 1 equiv of the electrophile or by subsequent addition of two different electrophiles are possible and lead to polyfunctional amide derivatives of the biuret type which are otherwise not easily accessible.

Specification for the U.S. Geological Survey Historical Topographic Map Collection

USGS Publications Warehouse

Allord, Gregory J.; Walter, Jennifer L.; Fishburn, Kristin A.; Shea, Gale A.

2014-01-01

This document provides the detailed requirements for producing, archiving, and disseminating a comprehensive digital collection of topographic maps for the U.S. Geological Survey (USGS) Historical Topographic Map Collection (HTMC). The HTMC is a digital archive of about 190,000 printed topographic maps published by the USGS from the inception of the topographic mapping program in 1884 until the last paper topographic map using lithographic printing technology was published in 2006. The HTMC provides a comprehensive digital repository of all scales and all editions of USGS printed topographic maps that is easily discovered, browsed, and downloaded by the public at no cost. The HTMC provides ready access to maps that are no longer available for distribution in print. A digital file representing the original paper historical topographic map is produced for each historical map in the HTMC in georeferenced PDF (GeoPDF) format (a portable document format [PDF] with a geospatial extension).

Profex: a graphical user interface for the Rietveld refinement program BGMN

PubMed Central

Doebelin, Nicola; Kleeberg, Reinhard

2015-01-01

Profex is a graphical user interface for the Rietveld refinement program BGMN. Its interface focuses on preserving BGMN’s powerful and flexible scripting features by giving direct access to BGMN input files. Very efficient workflows for single or batch refinements are achieved by managing refinement control files and structure files, by providing dialogues and shortcuts for many operations, by performing operations in the background, and by providing import filters for CIF and XML crystal structure files. Refinement results can be easily exported for further processing. State-of-the-art graphical export of diffraction patterns to pixel and vector graphics formats allows the creation of publication-quality graphs with minimum effort. Profex reads and converts a variety of proprietary raw data formats and is thus largely instrument independent. Profex and BGMN are available under an open-source license for Windows, Linux and OS X operating systems. PMID:26500466

Free-standing supramolecular hydrogel objects by reaction-diffusion

PubMed Central

Lovrak, Matija; Hendriksen, Wouter E. J.; Maity, Chandan; Mytnyk, Serhii; van Steijn, Volkert; Eelkema, Rienk; van Esch, Jan H.

2017-01-01

Self-assembly provides access to a variety of molecular materials, yet spatial control over structure formation remains difficult to achieve. Here we show how reaction–diffusion (RD) can be coupled to a molecular self-assembly process to generate macroscopic free-standing objects with control over shape, size, and functionality. In RD, two or more reactants diffuse from different positions to give rise to spatially defined structures on reaction. We demonstrate that RD can be used to locally control formation and self-assembly of hydrazone molecular gelators from their non-assembling precursors, leading to soft, free-standing hydrogel objects with sizes ranging from several hundred micrometres up to centimeters. Different chemical functionalities and gradients can easily be integrated in the hydrogel objects by using different reactants. Our methodology, together with the vast range of organic reactions and self-assembling building blocks, provides a general approach towards the programmed fabrication of soft microscale objects with controlled functionality and shape. PMID:28580948

Memory-based frame synchronizer. [for digital communication systems

NASA Technical Reports Server (NTRS)

Stattel, R. J.; Niswander, J. K. (Inventor)

1981-01-01

A frame synchronizer for use in digital communications systems wherein data formats can be easily and dynamically changed is described. The use of memory array elements provide increased flexibility in format selection and sync word selection in addition to real time reconfiguration ability. The frame synchronizer comprises a serial-to-parallel converter which converts a serial input data stream to a constantly changing parallel data output. This parallel data output is supplied to programmable sync word recognizers each consisting of a multiplexer and a random access memory (RAM). The multiplexer is connected to both the parallel data output and an address bus which may be connected to a microprocessor or computer for purposes of programming the sync word recognizer. The RAM is used as an associative memory or decorder and is programmed to identify a specific sync word. Additional programmable RAMs are used as counter decoders to define word bit length, frame word length, and paragraph frame length.

An interactive program for computer-aided map design, display, and query: EMAPKGS2

USGS Publications Warehouse

Pouch, G.W.

1997-01-01

EMAPKGS2 is a user-friendly, PC-based electronic mapping tool for use in hydrogeologic exploration and appraisal. EMAPKGS2 allows the analyst to construct maps interactively from data stored in a relational database, perform point-oriented spatial queries such as locating all wells within a specified radius, perform geographic overlays, and export the data to other programs for further analysis. EMAPKGS2 runs under Microsoft?? Windows??? 3.1 and compatible operating systems. EMAPKGS2 is a public domain program available from the Kansas Geological Survey. EMAPKGS2 is the centerpiece of WHEAT, the Windows-based Hydrogeologic Exploration and Appraisal Toolkit, a suite of user-friendly Microsoft?? Windows??? programs for natural resource exploration and management. The principal goals in development of WHEAT have been ease of use, hardware independence, low cost, and end-user extensibility. WHEAT'S native data format is a Microsoft?? Access?? database. WHEAT stores a feature's geographic coordinates as attributes so they can be accessed easily by the user. The WHEAT programs are designed to be used in conjunction with other Microsoft?? Windows??? software to allow the natural resource scientist to perform work easily and effectively. WHEAT and EMAPKGS have been used at several of Kansas' Groundwater Management Districts and the Kansas Geological Survey on groundwater management operations, groundwater modeling projects, and geologic exploration projects. ?? 1997 Elsevier Science Ltd.

Accessing Cloud Properties and Satellite Imagery: A tool for visualization and data mining

NASA Astrophysics Data System (ADS)

Chee, T.; Nguyen, L.; Minnis, P.; Spangenberg, D.; Palikonda, R.

2016-12-01

Providing public access to imagery of cloud macro and microphysical properties and the underlying satellite imagery is a key concern for the NASA Langley Research Center Cloud and Radiation Group. This work describes a tool and system that allows end users to easily browse cloud information and satellite imagery that is otherwise difficult to acquire and manipulate. The tool has two uses, one to visualize the data and the other to access the data directly. It uses a widely used access protocol, the Open Geospatial Consortium's Web Map and Processing Services, to encourage user to access the data we produce. Internally, we leverage our practical experience with large, scalable application practices to develop a system that has the largest potential for scalability as well as the ability to be deployed on the cloud. One goal of the tool is to provide a demonstration of the back end capability to end users so that they can use the dynamically generated imagery and data as an input to their own work flows or to set up data mining constraints. We build upon NASA Langley Cloud and Radiation Group's experience with making real-time and historical satellite cloud product information and satellite imagery accessible and easily searchable. Increasingly, information is used in a "mash-up" form where multiple sources of information are combined to add value to disparate but related information. In support of NASA strategic goals, our group aims to make as much cutting edge scientific knowledge, observations and products available to the citizen science, research and interested communities for these kinds of "mash-ups" as well as provide a means for automated systems to data mine our information. This tool and access method provides a valuable research tool to a wide audience both as a standalone research tool and also as an easily accessed data source that can easily be mined or used with existing tools.

CDSbank: taxonomy-aware extraction, selection, renaming and formatting of protein-coding DNA or amino acid sequences.

PubMed

Hazes, Bart

2014-02-28

Protein-coding DNA sequences and their corresponding amino acid sequences are routinely used to study relationships between sequence, structure, function, and evolution. The rapidly growing size of sequence databases increases the power of such comparative analyses but it makes it more challenging to prepare high quality sequence data sets with control over redundancy, quality, completeness, formatting, and labeling. Software tools for some individual steps in this process exist but manual intervention remains a common and time consuming necessity. CDSbank is a database that stores both the protein-coding DNA sequence (CDS) and amino acid sequence for each protein annotated in Genbank. CDSbank also stores Genbank feature annotation, a flag to indicate incomplete 5' and 3' ends, full taxonomic data, and a heuristic to rank the scientific interest of each species. This rich information allows fully automated data set preparation with a level of sophistication that aims to meet or exceed manual processing. Defaults ensure ease of use for typical scenarios while allowing great flexibility when needed. Access is via a free web server at http://hazeslab.med.ualberta.ca/CDSbank/. CDSbank presents a user-friendly web server to download, filter, format, and name large sequence data sets. Common usage scenarios can be accessed via pre-programmed default choices, while optional sections give full control over the processing pipeline. Particular strengths are: extract protein-coding DNA sequences just as easily as amino acid sequences, full access to taxonomy for labeling and filtering, awareness of incomplete sequences, and the ability to take one protein sequence and extract all synonymous CDS or identical protein sequences in other species. Finally, CDSbank can also create labeled property files to, for instance, annotate or re-label phylogenetic trees.

Data Sets and Data Services at the Northern California Earthquake Data Center

NASA Astrophysics Data System (ADS)

Neuhauser, D. S.; Zuzlewski, S.; Allen, R. M.

2014-12-01

The Northern California Earthquake Data Center (NCEDC) houses a unique and comprehensive data archive and provides real-time services for a variety of seismological and geophysical data sets that encompass northern and central California. We have over 80 terabytes of continuous and event-based time series data from broadband, short-period, strong motion, and strain sensors as well as continuous and campaign GPS data at both standard and high sample rates in both raw and RINEX format. The Northen California Seismic System (NCSS), operated by UC Berkeley and USGS Menlo Park, has recorded over 890,000 events from 1984 to the present, and the NCEDC provides catalog, parametric information, moment tensors and first motion mechanisms, and time series data for these events. We also host and provide event catalogs, parametric information, and event waveforms for DOE enhanced geothermal system monitoring in northern California and Nevada. The NCEDC provides a variety of ways for users to access these data. The most recent development are web services, which provide interactive, command-line, or program-based workflow access to data. Web services use well-established server and client protocols and RESTful software architecture that allow users to easily submit queries and receive the requested data in real-time rather than through batch or email-based requests. Data are returned to the user in the appropriate format such as XML, RESP, simple text, or MiniSEED depending on the service and selected output format. The NCEDC supports all FDSN-defined web services as well as a number of IRIS-defined and NCEDC-defined services. We also continue to support older email-based and browser-based access to data. NCEDC data and web services can be found at http://www.ncedc.org and http://service.ncedc.org.

Novel design for transparent high-pressure fuel injector nozzles.

PubMed

Falgout, Z; Linne, M

2016-08-01

The efficiency and emissions of internal combustion (IC) engines are closely tied to the formation of the combustible air-fuel mixture. Direct-injection engines have become more common due to their increased practical flexibility and efficiency, and sprays dominate mixture formation in these engines. Spray formation, or rather the transition from a cylindrical liquid jet to a field of isolated droplets, is not completely understood. However, it is known that nozzle orifice flow and cavitation have an important effect on the formation of fuel injector sprays, even if the exact details of this effect remain unknown. A number of studies in recent years have used injectors with optically transparent nozzles (OTN) to allow observation of the nozzle orifice flow. Our goal in this work is to design various OTN concepts that mimic the flow inside commercial injector nozzles, at realistic fuel pressures, and yet still allow access to the very near nozzle region of the spray so that interior flow structure can be correlated with primary breakup dynamics. This goal has not been achieved until now because interior structures can be very complex, and the most appropriate optical materials are brittle and easily fractured by realistic fuel pressures. An OTN design that achieves realistic injection pressures and grants visual access to the interior flow and spray formation will be explained in detail. The design uses an acrylic nozzle, which is ideal for imaging the interior flow. This nozzle is supported from the outside with sapphire clamps, which reduces tensile stresses in the nozzle and increases the nozzle's injection pressure capacity. An ensemble of nozzles were mechanically tested to prove this design concept.

Colorful protein-based fluorescent probes for collagen imaging.

PubMed

Aper, Stijn J A; van Spreeuwel, Ariane C C; van Turnhout, Mark C; van der Linden, Ardjan J; Pieters, Pascal A; van der Zon, Nick L L; de la Rambelje, Sander L; Bouten, Carlijn V C; Merkx, Maarten

2014-01-01

Real-time visualization of collagen is important in studies on tissue formation and remodeling in the research fields of developmental biology and tissue engineering. Our group has previously reported on a fluorescent probe for the specific imaging of collagen in live tissue in situ, consisting of the native collagen binding protein CNA35 labeled with fluorescent dye Oregon Green 488 (CNA35-OG488). The CNA35-OG488 probe has become widely used for collagen imaging. To allow for the use of CNA35-based probes in a broader range of applications, we here present a toolbox of six genetically-encoded collagen probes which are fusions of CNA35 to fluorescent proteins that span the visible spectrum: mTurquoise2, EGFP, mAmetrine, LSSmOrange, tdTomato and mCherry. While CNA35-OG488 requires a chemical conjugation step for labeling with the fluorescent dye, these protein-based probes can be easily produced in high yields by expression in E. coli and purified in one step using Ni2+-affinity chromatography. The probes all bind specifically to collagen, both in vitro and in porcine pericardial tissue. Some first applications of the probes are shown in multicolor imaging of engineered tissue and two-photon imaging of collagen in human skin. The fully-genetic encoding of the new probes makes them easily accessible to all scientists interested in collagen formation and remodeling.

Synthesis of tris- and tetrakis(pentafluoroethyl)silanes.

PubMed

Steinhauer, Simon; Bader, Julia; Stammler, Hans-Georg; Ignat'ev, Nikolai; Hoge, Berthold

2014-05-12

The synthesis and complete characterization of functional, highly Lewis acidic tris(pentafluoroethyl)silanes as well as tetrakis(perfluoroalkyl)silanes Si(C2F5)4 and Si(C2F5)3 CF3 by direct fluorination is described. The reaction of SiCl4 with LiC2F5 invariably affords (pentafluoroethyl)fluorosilicates. To avoid silicate formation by fluoride transfer from LiC2F5 the Lewis acidity of the silane has to be decreased by electron-donating substituents, such as dialkylamino groups. The easily accessible Si(C2F5)3 NEt2 is a valuable precursor for a series of tris(pentafluoroethyl)silanes. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

NASA climate data catalog

NASA Technical Reports Server (NTRS)

Reph, M. G.

1984-01-01

This document provides a summary of information available in the NASA Climate Data Catalog. The catalog provides scientific users with technical information about selected climate parameter data sets and the associated sensor measurements from which they are derived. It is an integral part of the Pilot Climate Data System (PCDS), an interactive, scientific management system for locating, obtaining, manipulating, and displaying climate research data. The catalog is maintained in a machine readable representation which can easily be accessed via the PCDS. The purposes, format and content of the catalog are discussed. Summarized information is provided about each of the data sets currently described in the catalog. Sample detailed descriptions are included for individual data sets or families of related data sets.

Divergent Synthesis of Multisubstituted Tetrahydrofurans and Pyrrolidines via Intramolecular Aldol-type Trapping of Onium Ylide Intermediates.

PubMed

Jing, Changcheng; Xing, Dong; Gao, Lixin; Li, Jia; Hu, Wenhao

2015-12-21

This paper reports a divergent strategy for the synthesis of multisubstituted tetrahydrofurans and pyrrolidines, starting from easily accessible β-hydroxyketones or β-aminoketones to react with diazo compounds. Under Rh(II) catalysis, this transformation is proposed to proceed through a metal-carbene-induced oxonium ylide or ammonium ylide formation followed by an intramolecular aldol-type trapping of these active intermediates. A series of highly substituted tetrahydrofurans and pyrrolidines are synthesized in high yields with good to excellent diastereoselectivities. Preliminary biological evaluations revealed that both types of heterocycles show good PTP1B inhibitory activities. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Automated extraction of knowledge for model-based diagnostics

NASA Technical Reports Server (NTRS)

Gonzalez, Avelino J.; Myler, Harley R.; Towhidnejad, Massood; Mckenzie, Frederic D.; Kladke, Robin R.

1990-01-01

The concept of accessing computer aided design (CAD) design databases and extracting a process model automatically is investigated as a possible source for the generation of knowledge bases for model-based reasoning systems. The resulting system, referred to as automated knowledge generation (AKG), uses an object-oriented programming structure and constraint techniques as well as internal database of component descriptions to generate a frame-based structure that describes the model. The procedure has been designed to be general enough to be easily coupled to CAD systems that feature a database capable of providing label and connectivity data from the drawn system. The AKG system is capable of defining knowledge bases in formats required by various model-based reasoning tools.

The iMeteo is a web-based weather visualization tool

NASA Astrophysics Data System (ADS)

Tuni San-Martín, Max; San-Martín, Daniel; Cofiño, Antonio S.

2010-05-01

iMeteo is a web-based weather visualization tool. Designed with an extensible J2EE architecture, it is capable of displaying information from heterogeneous data sources such as gridded data from numerical models (in NetCDF format) or databases of local predictions. All this information is presented in a user-friendly way, being able to choose the specific tool to display data (maps, graphs, information tables) and customize it to desired locations. *Modular Display System* Visualization of the data is achieved through a set of mini tools called widgets. A user can add them at will and arrange them around the screen easily with a drag and drop movement. They can be of various types and each can be configured separately, forming a really powerful and configurable system. The "Map" is the most complex widget, since it can show several variables simultaneously (either gridded or point-based) through a layered display. Other useful widgets are the the "Histogram", which generates a graph with the frequency characteristics of a variable and the "Timeline" which shows the time evolution of a variable at a given location in an interactive way. *Customization and security* Following the trends in web development, the user can easily customize the way data is displayed. Due to programming in client side with technologies like AJAX, the interaction with the application is similar to the desktop ones because there are rapid respone times. If a user is registered then he could also save his settings in the database, allowing access from any system with Internet access with his particular setup. There is particular emphasis on application security. The administrator can define a set of user profiles, which may have associated restrictions on access to certain data sources, geographic areas or time intervals.

A Simple and Novel Method to Attain Retrograde Ureteral Access after Previous Cohen Cross-Trigonal Ureteral Reimplantation

PubMed Central

Adam, Ahmed

2017-01-01

Objective To describe a simple, novel method to achieve ureteric access in the Cohen crossed reimplanted ureter, which will allow retrograde working access via the conventional transurethral method. Materials and Methods Under cystoscopic vision, suprapubic needle puncture was performed. The needle was directed (bevel facing) towards the desired ureteric orifice (UO). A guidewire (with a floppy-tip) was then inserted into the suprapubic needle passing into the bladder, and then easily passed into the crossed-reimplanted UO. The distal end of the guidewire was then removed through the urethra with cystoscopic grasping forceps. The straightened ureter then easily facilitated ureteroscopy access, retrograde pyelogram studies, and JJ stent insertion in a conventional transurethral method. Results The UO and ureter were aligned in a more conventional orthotopic course, to allow for conventional transurethral working access. Conclusion A novel method to access the Cohen crossed reimplanted ureter was described. All previously published methods of accessing the crossed ureter were critically appraised. PMID:29463976

All-optical VPN utilizing DSP-based digital orthogonal filters access for PONs

NASA Astrophysics Data System (ADS)

Zhang, Xiaoling; Zhang, Chongfu; Chen, Chen; Jin, Wei; Qiu, Kun

2018-04-01

Utilizing digital filtering-enabled signal multiplexing and de-multiplexing, a cost-effective all-optical virtual private network (VPN) system is proposed, for the first time to our best knowledge, in digital filter multiple access passive optical networks (DFMA-PONs). Based on the DFMA technology, the proposed system can be easily designed to meet the requirements of next generation network's flexibility, elasticity, adaptability and compatibility. Through dynamic digital filter allocation and recycling, the proposed all-optical VPN system can provide dynamic establishments and cancellations of multiple VPN communications with arbitrary traffic volumes. More importantly, due to the employment of DFMA technology, the system is not limited to a fixed signal format and different signal formats such as pulse amplitude modulation (PAM), quadrature amplitude modulation (QAM) and orthogonal frequency division multiplexing (OFDM) can be used. Moreover, one transceiver is sufficient to simultaneously transmit upstream (US)/VPN data to optical line terminal (OLT) or other VPN optical network units (ONUs), thus leading to great reduction in network constructions and operation expenditures. The proposed all-optical VPN system is demonstrated with the transceiver incorporating the formats of QAM and OFDM, which can be made transparent to downstream (DS), US and VPN communications. The bit error rates (BERs) of DS, US and VPN for OFDM signals are below the forward-error-correction (FEC) limit of 3 . 8 × 10-3 when the received optical powers are about -16.8 dBm, -14.5 dBm and -15.7 dBm, respectively.

Using the ATL HDI 1000 to collect demodulated RF data for monitoring HIFU lesion formation

NASA Astrophysics Data System (ADS)

Anand, Ajay; Kaczkowski, Peter J.; Daigle, Ron E.; Huang, Lingyun; Paun, Marla; Beach, Kirk W.; Crum, Lawrence A.

2003-05-01

The ability to accurately track and monitor the progress of lesion formation during HIFU (High Intensity Focused Ultrasound) therapy is important for the success of HIFU-based treatment protocols. To aid in the development of algorithms for accurately targeting and monitoring formation of HIFU induced lesions, we have developed a software system to perform RF data acquisition during HIFU therapy using a commercially available clinical ultrasound scanner (ATL HDI 1000, Philips Medical Systems, Bothell, WA). The HDI 1000 scanner functions on a software dominant architecture, permitting straightforward external control of its operation and relatively easy access to quadrature demodulated RF data. A PC running a custom developed program sends control signals to the HIFU module via GPIB and to the HDI 1000 via Telnet, alternately interleaving HIFU exposures and RF frame acquisitions. The system was tested during experiments in which HIFU lesions were created in excised animal tissue. No crosstalk between the HIFU beam and the ultrasound imager was detected, thus demonstrating synchronization. Newly developed acquisition modes allow greater user control in setting the image geometry and scanline density, and enables high frame rate acquisition. This system facilitates rapid development of signal-processing based HIFU therapy monitoring algorithms and their implementation in image-guided thermal therapy systems. In addition, the HDI 1000 system can be easily customized for use with other emerging imaging modalities that require access to the RF data such as elastographic methods and new Doppler-based imaging and tissue characterization techniques.

NASA Earth Observations (NEO): Data Access for Informal Education and Outreach

NASA Technical Reports Server (NTRS)

Ward, Kevin; Herring, David

2005-01-01

The NEO (NASA Earth Observations) web space is currently under development with the goal of significantly increasing the demand for NASA remote sensing data while dramatically simplifying public access to georeferenced images. NEO will target the unsophisticated, nontraditional data users who are currently underserved by the existing data ordering systems. These users will include formal and informal educators, museum and science center personnel, professional communicators, and citizen scientists and amateur Earth observers. Users will be able to view and manipulate georeferenced browse imagery and, if they desire, download directly or order the source HDF data from the data provider (e.g., NASA DAAC or science team) via a single, integrated interface. NE0 will accomplish this goal by anticipating users expectations and knowledge level, thus providing an interface that presents material to users in a more simplified manner, without relying upon the jargon/technical terminology that make even the identification of the appropriate data set a significant hurdle. NEO will also act as a gateway that manages users expectations by providing specific details about images and data formats, developing tutorials regarding the manipulation of georeferenced imagery and raw data, links to software tools and ensuring that users are able to get the image they want in the format they want as easily as possible.

Redesigning NASA Earthdata to Become Powered by EOSDIS Components

NASA Astrophysics Data System (ADS)

Bagwell, R.; Siarto, J.; Wong, M. M.; Murphy, K. J.; McLaughlin, B. D.

2014-12-01

Two years ago, NASA's Earth Science Data and Information Systems (ESDIS) Project launched the Earthdata website (https://earthdata.nasa.gov) in order to make Earth Observing System Data and Information System (EOSDIS) data, data products, data tools, and services available to a broad range of user communities across Earth science disciplines to foster collaboration and learning amongst the communities. Earthdata is being redesigned to be the one-stop shop in providing Earth science data, services, and information to the Earth science community. The goal is to move from the current static, manually-intensive content format to a dynamic, data-driven website in order to provide a more flexible and usable design website infrastructure that leverages EOSDIS components such as the User Registration System (URS), the Common Metadata Repository (CMR) and the Global Imagery Browse Services (GIBS). This will reorganize information content to make the website easier to use and to make easily accessible the high-value Earth science content throughout the site. The website will also easily accept and incorporate upcoming new projects such as the Earthdata Search Client and the Sea Level Change Portal.

Northern California Earthquake Data Center: Data Sets and Data Services

NASA Astrophysics Data System (ADS)

Neuhauser, D. S.; Allen, R. M.; Zuzlewski, S.

2015-12-01

The Northern California Earthquake Data Center (NCEDC) provides a permanent archive and real-time data distribution services for a unique and comprehensive data set of seismological and geophysical data sets encompassing northern and central California. We provide access to over 85 terabytes of continuous and event-based time series data from broadband, short-period, strong motion, and strain sensors as well as continuous and campaign GPS data at both standard and high sample rates. The Northen California Seismic System (NCSS), operated by UC Berkeley and USGS Menlo Park, has recorded over 900,000 events from 1984 to the present, and the NCEDC serves catalog, parametric information, moment tensors and first motion mechanisms, and time series data for these events. We also serve event catalogs, parametric information, and event waveforms for DOE enhanced geothermal system monitoring in northern California and Nevada. The NCEDC provides a several ways for users to access these data. The most recent development are web services, which provide interactive, command-line, or program-based workflow access to data. Web services use well-established server and client protocols and RESTful software architecture that allow users to easily submit queries and receive the requested data in real-time rather than through batch or email-based requests. Data are returned to the user in the appropriate format such as XML, RESP, simple text, or MiniSEED depending on the service and selected output format. The NCEDC supports all FDSN-defined web services as well as a number of IRIS-defined and NCEDC-defined services. We also continue to support older email-based and browser-based access to data. NCEDC data and web services can be found at http://www.ncedc.org and http://service.ncedc.org.

ExpoCastDB: A Publicly Accessible Database for Observational Exposure Data

EPA Science Inventory

The application of environmental informatics tools for human health risk assessment will require the development of advanced exposure information technology resources. Exposure data for chemicals is often not readily accessible. There is a pressing need for easily accessible, che...

SWS: accessing SRS sites contents through Web Services.

PubMed

Romano, Paolo; Marra, Domenico

2008-03-26

Web Services and Workflow Management Systems can support creation and deployment of network systems, able to automate data analysis and retrieval processes in biomedical research. Web Services have been implemented at bioinformatics centres and workflow systems have been proposed for biological data analysis. New databanks are often developed by taking into account these technologies, but many existing databases do not allow a programmatic access. Only a fraction of available databanks can thus be queried through programmatic interfaces. SRS is a well know indexing and search engine for biomedical databanks offering public access to many databanks and analysis tools. Unfortunately, these data are not easily and efficiently accessible through Web Services. We have developed 'SRS by WS' (SWS), a tool that makes information available in SRS sites accessible through Web Services. Information on known sites is maintained in a database, srsdb. SWS consists in a suite of WS that can query both srsdb, for information on sites and databases, and SRS sites. SWS returns results in a text-only format and can be accessed through a WSDL compliant client. SWS enables interoperability between workflow systems and SRS implementations, by also managing access to alternative sites, in order to cope with network and maintenance problems, and selecting the most up-to-date among available systems. Development and implementation of Web Services, allowing to make a programmatic access to an exhaustive set of biomedical databases can significantly improve automation of in-silico analysis. SWS supports this activity by making biological databanks that are managed in public SRS sites available through a programmatic interface.

SiGe epitaxial memory for neuromorphic computing with reproducible high performance based on engineered dislocations

NASA Astrophysics Data System (ADS)

Choi, Shinhyun; Tan, Scott H.; Li, Zefan; Kim, Yunjo; Choi, Chanyeol; Chen, Pai-Yu; Yeon, Hanwool; Yu, Shimeng; Kim, Jeehwan

2018-01-01

Although several types of architecture combining memory cells and transistors have been used to demonstrate artificial synaptic arrays, they usually present limited scalability and high power consumption. Transistor-free analog switching devices may overcome these limitations, yet the typical switching process they rely on—formation of filaments in an amorphous medium—is not easily controlled and hence hampers the spatial and temporal reproducibility of the performance. Here, we demonstrate analog resistive switching devices that possess desired characteristics for neuromorphic computing networks with minimal performance variations using a single-crystalline SiGe layer epitaxially grown on Si as a switching medium. Such epitaxial random access memories utilize threading dislocations in SiGe to confine metal filaments in a defined, one-dimensional channel. This confinement results in drastically enhanced switching uniformity and long retention/high endurance with a high analog on/off ratio. Simulations using the MNIST handwritten recognition data set prove that epitaxial random access memories can operate with an online learning accuracy of 95.1%.

WormQTL—public archive and analysis web portal for natural variation data in Caenorhabditis spp

PubMed Central

Snoek, L. Basten; Van der Velde, K. Joeri; Arends, Danny; Li, Yang; Beyer, Antje; Elvin, Mark; Fisher, Jasmin; Hajnal, Alex; Hengartner, Michael O.; Poulin, Gino B.; Rodriguez, Miriam; Schmid, Tobias; Schrimpf, Sabine; Xue, Feng; Jansen, Ritsert C.; Kammenga, Jan E.; Swertz, Morris A.

2013-01-01

Here, we present WormQTL (http://www.wormqtl.org), an easily accessible database enabling search, comparative analysis and meta-analysis of all data on variation in Caenorhabditis spp. Over the past decade, Caenorhabditis elegans has become instrumental for molecular quantitative genetics and the systems biology of natural variation. These efforts have resulted in a valuable amount of phenotypic, high-throughput molecular and genotypic data across different developmental worm stages and environments in hundreds of C. elegans strains. WormQTL provides a workbench of analysis tools for genotype–phenotype linkage and association mapping based on but not limited to R/qtl (http://www.rqtl.org). All data can be uploaded and downloaded using simple delimited text or Excel formats and are accessible via a public web user interface for biologists and R statistic and web service interfaces for bioinformaticians, based on open source MOLGENIS and xQTL workbench software. WormQTL welcomes data submissions from other worm researchers. PMID:23180786

WormQTL--public archive and analysis web portal for natural variation data in Caenorhabditis spp.

PubMed

Snoek, L Basten; Van der Velde, K Joeri; Arends, Danny; Li, Yang; Beyer, Antje; Elvin, Mark; Fisher, Jasmin; Hajnal, Alex; Hengartner, Michael O; Poulin, Gino B; Rodriguez, Miriam; Schmid, Tobias; Schrimpf, Sabine; Xue, Feng; Jansen, Ritsert C; Kammenga, Jan E; Swertz, Morris A

2013-01-01

Here, we present WormQTL (http://www.wormqtl.org), an easily accessible database enabling search, comparative analysis and meta-analysis of all data on variation in Caenorhabditis spp. Over the past decade, Caenorhabditis elegans has become instrumental for molecular quantitative genetics and the systems biology of natural variation. These efforts have resulted in a valuable amount of phenotypic, high-throughput molecular and genotypic data across different developmental worm stages and environments in hundreds of C. elegans strains. WormQTL provides a workbench of analysis tools for genotype-phenotype linkage and association mapping based on but not limited to R/qtl (http://www.rqtl.org). All data can be uploaded and downloaded using simple delimited text or Excel formats and are accessible via a public web user interface for biologists and R statistic and web service interfaces for bioinformaticians, based on open source MOLGENIS and xQTL workbench software. WormQTL welcomes data submissions from other worm researchers.

Novel, Web-based, information-exploration approach for improving operating room logistics and system processes.

PubMed

Nagy, Paul G; Konewko, Ramon; Warnock, Max; Bernstein, Wendy; Seagull, Jacob; Xiao, Yan; George, Ivan; Park, Adrian

2008-03-01

Routine clinical information systems now have the ability to gather large amounts of data that surgical managers can access to create a seamless and proactive approach to streamlining operations and minimizing delays. The challenge lies in aggregating and displaying these data in an easily accessible format that provides useful, timely information on current operations. A Web-based, graphical dashboard is described in this study, which can be used to interpret clinical operational data, allow managers to see trends in data, and help identify inefficiencies that were not apparent with more traditional, paper-based approaches. The dashboard provides a visual decision support tool that assists managers in pinpointing areas for continuous quality improvement. The limitations of paper-based techniques, the development of the automated display system, and key performance indicators in analyzing aggregate delays, time, specialties, and teamwork are reviewed. Strengths, weaknesses, opportunities, and threats associated with implementing such a program in the perioperative environment are summarized.

An Adaptable Seismic Data Format for Modern Scientific Workflows

NASA Astrophysics Data System (ADS)

Smith, J. A.; Bozdag, E.; Krischer, L.; Lefebvre, M.; Lei, W.; Podhorszki, N.; Tromp, J.

2013-12-01

Data storage, exchange, and access play a critical role in modern seismology. Current seismic data formats, such as SEED, SAC, and SEG-Y, were designed with specific applications in mind and are frequently a major bottleneck in implementing efficient workflows. We propose a new modern parallel format that can be adapted for a variety of seismic workflows. The Adaptable Seismic Data Format (ASDF) features high-performance parallel read and write support and the ability to store an arbitrary number of traces of varying sizes. Provenance information is stored inside the file so that users know the origin of the data as well as the precise operations that have been applied to the waveforms. The design of the new format is based on several real-world use cases, including earthquake seismology and seismic interferometry. The metadata is based on the proven XML schemas StationXML and QuakeML. Existing time-series analysis tool-kits are easily interfaced with this new format so that seismologists can use robust, previously developed software packages, such as ObsPy and the SAC library. ADIOS, netCDF4, and HDF5 can be used as the underlying container format. At Princeton University, we have chosen to use ADIOS as the container format because it has shown superior scalability for certain applications, such as dealing with big data on HPC systems. In the context of high-performance computing, we have implemented ASDF into the global adjoint tomography workflow on Oak Ridge National Laboratory's supercomputer Titan.

Spreadsheet log analysis in subsurface geology

USGS Publications Warehouse

Doveton, J.H.

2000-01-01

Most of the direct knowledge of the geology of the subsurface is gained from the examination of core and drill-cuttings recovered from boreholes drilled by the petroleum and water industries. Wireline logs run in these same boreholes generally have been restricted to tasks of lithostratigraphic correlation and thee location of hydrocarbon pay zones. However, the range of petrophysical measurements has expanded markedly in recent years, so that log traces now can be transformed to estimates of rock composition. Increasingly, logs are available in a digital format that can be read easily by a desktop computer and processed by simple spreadsheet software methods. Taken together, these developments offer accessible tools for new insights into subsurface geology that complement the traditional, but limited, sources of core and cutting observations.

Cinfony – combining Open Source cheminformatics toolkits behind a common interface

PubMed Central

O'Boyle, Noel M; Hutchison, Geoffrey R

2008-01-01

Background Open Source cheminformatics toolkits such as OpenBabel, the CDK and the RDKit share the same core functionality but support different sets of file formats and forcefields, and calculate different fingerprints and descriptors. Despite their complementary features, using these toolkits in the same program is difficult as they are implemented in different languages (C++ versus Java), have different underlying chemical models and have different application programming interfaces (APIs). Results We describe Cinfony, a Python module that presents a common interface to all three of these toolkits, allowing the user to easily combine methods and results from any of the toolkits. In general, the run time of the Cinfony modules is almost as fast as accessing the underlying toolkits directly from C++ or Java, but Cinfony makes it much easier to carry out common tasks in cheminformatics such as reading file formats and calculating descriptors. Conclusion By providing a simplified interface and improving interoperability, Cinfony makes it easy to combine complementary features of OpenBabel, the CDK and the RDKit. PMID:19055766

Efficient generation of integration-free human induced pluripotent stem cells from keratinocytes by simple transfection of episomal vectors.

PubMed

Piao, Yulan; Hung, Sandy Shen-Chi; Lim, Shiang Y; Wong, Raymond Ching-Bong; Ko, Minoru S H

2014-07-01

Keratinocytes represent an easily accessible cell source for derivation of human induced pluripotent stem (hiPS) cells, reportedly achieving higher reprogramming efficiency than fibroblasts. However, most studies utilized a retroviral or lentiviral method for reprogramming of keratinocytes, which introduces undesirable transgene integrations into the host genome. Moreover, current protocols of generating integration-free hiPS cells from keratinocytes are mostly inefficient. In this paper, we describe a more efficient, simple-to-use, and cost-effective method for generating integration-free hiPS cells from keratinocytes. Our improved method using lipid-mediated transfection achieved a reprogramming efficiency of ∼0.14% on average. Keratinocyte-derived hiPS cells showed no integration of episomal vectors, expressed stem cell-specific markers and possessed potentials to differentiate into all three germ layers by in vitro embryoid body formation as well as in vivo teratoma formation. To our knowledge, this represents the most efficient method to generate integration-free hiPS cells from keratinocytes. ©AlphaMed Press.

An exploratory study into the effect of time-restricted internet access on face-validity, construct validity and reliability of postgraduate knowledge progress testing

PubMed Central

2013-01-01

Background Yearly formative knowledge testing (also known as progress testing) was shown to have a limited construct-validity and reliability in postgraduate medical education. One way to improve construct-validity and reliability is to improve the authenticity of a test. As easily accessible internet has become inseparably linked to daily clinical practice, we hypothesized that allowing internet access for a limited amount of time during the progress test would improve the perception of authenticity (face-validity) of the test, which would in turn improve the construct-validity and reliability of postgraduate progress testing. Methods Postgraduate trainees taking the yearly knowledge progress test were asked to participate in a study where they could access the internet for 30 minutes at the end of a traditional pen and paper test. Before and after the test they were asked to complete a short questionnaire regarding the face-validity of the test. Results Mean test scores increased significantly for all training years. Trainees indicated that the face-validity of the test improved with internet access and that they would like to continue to have internet access during future testing. Internet access did not improve the construct-validity or reliability of the test. Conclusion Improving the face-validity of postgraduate progress testing, by adding the possibility to search the internet for a limited amount of time, positively influences test performance and face-validity. However, it did not change the reliability or the construct-validity of the test. PMID:24195696

Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach

PubMed Central

Crowther, Gregory J.; Shanmugam, Dhanasekaran; Carmona, Santiago J.; Doyle, Maria A.; Hertz-Fowler, Christiane; Berriman, Matthew; Nwaka, Solomon; Ralph, Stuart A.; Roos, David S.; Van Voorhis, Wesley C.; Agüero, Fernán

2010-01-01

Background The increased sequencing of pathogen genomes and the subsequent availability of genome-scale functional datasets are expected to guide the experimental work necessary for target-based drug discovery. However, a major bottleneck in this has been the difficulty of capturing and integrating relevant information in an easily accessible format for identifying and prioritizing potential targets. The open-access resource TDRtargets.org facilitates drug target prioritization for major tropical disease pathogens such as the mycobacteria Mycobacterium leprae and Mycobacterium tuberculosis; the kinetoplastid protozoans Leishmania major, Trypanosoma brucei, and Trypanosoma cruzi; the apicomplexan protozoans Plasmodium falciparum, Plasmodium vivax, and Toxoplasma gondii; and the helminths Brugia malayi and Schistosoma mansoni. Methodology/Principal Findings Here we present strategies to prioritize pathogen proteins based on whether their properties meet criteria considered desirable in a drug target. These criteria are based upon both sequence-derived information (e.g., molecular mass) and functional data on expression, essentiality, phenotypes, metabolic pathways, assayability, and druggability. This approach also highlights the fact that data for many relevant criteria are lacking in less-studied pathogens (e.g., helminths), and we demonstrate how this can be partially overcome by mapping data from homologous genes in well-studied organisms. We also show how individual users can easily upload external datasets and integrate them with existing data in TDRtargets.org to generate highly customized ranked lists of potential targets. Conclusions/Significance Using the datasets and the tools available in TDRtargets.org, we have generated illustrative lists of potential drug targets in seven tropical disease pathogens. While these lists are broadly consistent with the research community's current interest in certain specific proteins, and suggest novel target candidates that may merit further study, the lists can easily be modified in a user-specific manner, either by adjusting the weights for chosen criteria or by changing the criteria that are included. PMID:20808766

Establishing Community Learning and Information Centers (CLICs) in Underserved Malian Communities. Final Report

ERIC Educational Resources Information Center

Academy for Educational Development, 2005

2005-01-01

The purpose of the Community Learning and Information Center (CLIC) project was "to accelerate economic, social and political growth by providing residents in twelve underserved Malian communities with access to easily accessible development information and affordable access to information and communication technology (ICT), high-value…

Fluorine-containing composition for forming anti-reflection film on resist surface and pattern formation method

DOEpatents

Nishi, Mineo; Makishima, Hideo

1996-01-01

A composition for forming anti-reflection film on resist surface which comprises an aqueous solution of a water soluble fluorine compound, and a pattern formation method which comprises the steps of coating a photoresist composition on a substrate; coating the above-mentioned composition for forming anti-reflection film; exposing the coated film to form a specific pattern; and developing the photoresist, are provided. Since the composition for forming anti-reflection film can be coated on the photoresist in the form of an aqueous solution, not only the anti-reflection film can be formed easily, but also, the film can be removed easily by rinsing with water or alkali development. Therefore, by the pattern formation method according to the present invention, it is possible to form a pattern easily with a high dimensional accuracy.

The development of an imaging informatics-based multi-institutional platform to support sports performance and injury prevention in track and field

NASA Astrophysics Data System (ADS)

Liu, Joseph; Wang, Ximing; Verma, Sneha; McNitt-Gray, Jill; Liu, Brent

2018-03-01

The main goal of sports science and performance enhancement is to collect video and image data, process them, and quantify the results, giving insight to help athletes improve technique. For long jump in track and field, the processed output of video with force vector overlays and force calculations allow coaches to view specific stages of the hop, step, and jump, and identify how each stage can be improved to increase jump distance. Outputs also provide insight into how athletes can better maneuver to prevent injury. Currently, each data collection site collects and stores data with their own methods. There is no standard for data collection, formats, or storage. Video files and quantified results are stored in different formats, structures, and locations such as Dropbox and hard drives. Using imaging informatics-based principles we can develop a platform for multiple institutions that promotes the standardization of sports performance data. In addition, the system will provide user authentication and privacy as in clinical trials, with specific user access rights. Long jump data collected from different field sites will be standardized into specified formats before database storage. Quantified results from image-processing algorithms are stored similar to CAD algorithm results. The system will streamline the current sports performance data workflow and provide a user interface for athletes and coaches to view results of individual collections and also longitudinally across different collections. This streamlined platform and interface is a tool for coaches and athletes to easily access and review data to improve sports performance and prevent injury.

Making SAR Data Accessible - ASF's ALOS PALSAR Radiometric Terrain Correction Project

NASA Astrophysics Data System (ADS)

Meyer, F. J.; Arko, S. A.; Gens, R.

2015-12-01

While SAR data have proven valuable for a wide range of geophysical research questions, so far, largely only the SAR-educated science communities have been able to fully exploit the information content of internationally available SAR archives. The main issues that have been preventing a more widespread utilization of SAR are related to (1) the diversity and complexity of SAR data formats, (2) the complexity of the processing flows needed to extract geophysical information from SAR, (3) the lack of standardization and automation of these processing flows, and (4) the often ignored geocoding procedures, leaving the data in image coordinate space. In order to improve upon this situation, ASF's radiometric terrain-correction (RTC) project is generating uniformly formatted and easily accessible value-added products from the ASF Distributed Active Archive Center's (DAAC) five-year archive of JAXA's ALOS PALSAR sensor. Specifically, the project applies geometric and radiometric corrections to SAR data to allow for an easy and direct combination of obliquely acquired SAR data with remote sensing imagery acquired in nadir observation geometries. Finally, the value-added data is provided to the user in the broadly accepted Geotiff format, in order to support the easy integration of SAR data into GIS environments. The goal of ASF's RTC project is to make SAR data more accessible and more attractive to the broader SAR applications community, especially to those users that currently have limited SAR expertise. Production of RTC products commenced October 2014 and will conclude late in 2015. As of July 2015, processing of 71% of ASF's ALOS PALSAR archive was completed. Adding to the utility of this dataset are recent changes to the data access policy that allow the full-resolution RTC products to be provided to the public, without restriction. In this paper we will introduce the processing flow that was developed for the RTC project and summarize the calibration and validation procedures that were implemented to determine and monitor system performance. The paper will also show the current progress of RTC processing, provide examples of generated data sets, and demonstrate the benefit of the RTC archives for applications such as land-use classification and change detection.

Embedding online patient record access in UK primary care: a survey of stakeholder experiences.

PubMed

Pagliari, Claudia; Shand, Tim; Fisher, Brian

2012-05-01

To explore the integration of online patient Record Access within UK Primary Care, its perceived impacts on workload and service quality, and barriers to implementation. Mixed format survey of clinicians, administrators and patients. Telephone interviews with non-users. Primary care centres within NHS England that had offered online record access for the preceding year. Of the 57 practices initially agreeing to pilot the system, 32 had adopted it and 16 of these returned questionnaires. The 42 individual respondents included 14 practice managers, 15 clinicians and 13 patients. Follow-up interviews were conducted with one participant from 15 of the 25 non-adopter practices. Most professionals believed that the system is easy to integrate within primary care; while most patients found it easy to integrate within their daily lives. Professionals perceived no increase in the volume of patient queries or clinical consultations as a result of Record Access; indeed some believed that these had decreased. Most clinicians and patients believed that the service had improved mutual trust, communication, patients' health knowledge and health behaviour. Inhibiting factors included concerns about security, liability and resource requirements. Non-adoption was most frequently attributed to competing priorities, rather than negative beliefs about the service. Record access has an important role to play in supporting patient-focused healthcare policies in the UK and may be easily accommodated within existing services. Additional materials to facilitate patient recruitment, inform system set-up processes, and assure clinicians of their legal position are likely to encourage more widespread adoption.

Can front-of-pack labelling schemes guide healthier food choices? Australian shoppers' responses to seven labelling formats.

PubMed

Watson, Wendy L; Kelly, Bridget; Hector, Debra; Hughes, Clare; King, Lesley; Crawford, Jennifer; Sergeant, John; Chapman, Kathy

2014-01-01

There is evidence that easily accessible, comprehensible and consistent nutrient information on the front of packaged foods could assist shoppers to make healthier food choices. This study used an online questionnaire of 4357 grocery shoppers to examine Australian shoppers' ability to use a range of front-of-pack labels to identify healthier food products. Seven different front-of-pack labelling schemes comprising variants of the Traffic Light labelling scheme and the Percentage Daily Intake scheme, and a star rating scheme, were applied to nine pairs of commonly purchased food products. Participants could also access a nutrition information panel for each product. Participants were able to identify the healthier product in each comparison over 80% of the time using any of the five schemes that provided information on multiple nutrients. No individual scheme performed significantly better in terms of shoppers' ability to determine the healthier product, shopper reliance on the 'back-of-pack' nutrition information panel, and speed of use. The scheme that provided information about energy only and a scheme with limited numerical information of nutrient type or content performed poorly, as did the nutrition information panel alone (control). Further consumer testing is necessary to determine the optimal format and content of an interpretive front-of-pack nutrition labelling scheme. Copyright © 2013 Elsevier Ltd. All rights reserved.

The mzTab data exchange format: communicating mass-spectrometry-based proteomics and metabolomics experimental results to a wider audience.

PubMed

Griss, Johannes; Jones, Andrew R; Sachsenberg, Timo; Walzer, Mathias; Gatto, Laurent; Hartler, Jürgen; Thallinger, Gerhard G; Salek, Reza M; Steinbeck, Christoph; Neuhauser, Nadin; Cox, Jürgen; Neumann, Steffen; Fan, Jun; Reisinger, Florian; Xu, Qing-Wei; Del Toro, Noemi; Pérez-Riverol, Yasset; Ghali, Fawaz; Bandeira, Nuno; Xenarios, Ioannis; Kohlbacher, Oliver; Vizcaíno, Juan Antonio; Hermjakob, Henning

2014-10-01

The HUPO Proteomics Standards Initiative has developed several standardized data formats to facilitate data sharing in mass spectrometry (MS)-based proteomics. These allow researchers to report their complete results in a unified way. However, at present, there is no format to describe the final qualitative and quantitative results for proteomics and metabolomics experiments in a simple tabular format. Many downstream analysis use cases are only concerned with the final results of an experiment and require an easily accessible format, compatible with tools such as Microsoft Excel or R. We developed the mzTab file format for MS-based proteomics and metabolomics results to meet this need. mzTab is intended as a lightweight supplement to the existing standard XML-based file formats (mzML, mzIdentML, mzQuantML), providing a comprehensive summary, similar in concept to the supplemental material of a scientific publication. mzTab files can contain protein, peptide, and small molecule identifications together with experimental metadata and basic quantitative information. The format is not intended to store the complete experimental evidence but provides mechanisms to report results at different levels of detail. These range from a simple summary of the final results to a representation of the results including the experimental design. This format is ideally suited to make MS-based proteomics and metabolomics results available to a wider biological community outside the field of MS. Several software tools for proteomics and metabolomics have already adapted the format as an output format. The comprehensive mzTab specification document and extensive additional documentation can be found online. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

The mzTab Data Exchange Format: Communicating Mass-spectrometry-based Proteomics and Metabolomics Experimental Results to a Wider Audience*

PubMed Central

Griss, Johannes; Jones, Andrew R.; Sachsenberg, Timo; Walzer, Mathias; Gatto, Laurent; Hartler, Jürgen; Thallinger, Gerhard G.; Salek, Reza M.; Steinbeck, Christoph; Neuhauser, Nadin; Cox, Jürgen; Neumann, Steffen; Fan, Jun; Reisinger, Florian; Xu, Qing-Wei; del Toro, Noemi; Pérez-Riverol, Yasset; Ghali, Fawaz; Bandeira, Nuno; Xenarios, Ioannis; Kohlbacher, Oliver; Vizcaíno, Juan Antonio; Hermjakob, Henning

2014-01-01

The HUPO Proteomics Standards Initiative has developed several standardized data formats to facilitate data sharing in mass spectrometry (MS)-based proteomics. These allow researchers to report their complete results in a unified way. However, at present, there is no format to describe the final qualitative and quantitative results for proteomics and metabolomics experiments in a simple tabular format. Many downstream analysis use cases are only concerned with the final results of an experiment and require an easily accessible format, compatible with tools such as Microsoft Excel or R. We developed the mzTab file format for MS-based proteomics and metabolomics results to meet this need. mzTab is intended as a lightweight supplement to the existing standard XML-based file formats (mzML, mzIdentML, mzQuantML), providing a comprehensive summary, similar in concept to the supplemental material of a scientific publication. mzTab files can contain protein, peptide, and small molecule identifications together with experimental metadata and basic quantitative information. The format is not intended to store the complete experimental evidence but provides mechanisms to report results at different levels of detail. These range from a simple summary of the final results to a representation of the results including the experimental design. This format is ideally suited to make MS-based proteomics and metabolomics results available to a wider biological community outside the field of MS. Several software tools for proteomics and metabolomics have already adapted the format as an output format. The comprehensive mzTab specification document and extensive additional documentation can be found online. PMID:24980485

Pathogen metadata platform: software for accessing and analyzing pathogen strain information.

PubMed

Chang, Wenling E; Peterson, Matthew W; Garay, Christopher D; Korves, Tonia

2016-09-15

Pathogen metadata includes information about where and when a pathogen was collected and the type of environment it came from. Along with genomic nucleotide sequence data, this metadata is growing rapidly and becoming a valuable resource not only for research but for biosurveillance and public health. However, current freely available tools for analyzing this data are geared towards bioinformaticians and/or do not provide summaries and visualizations needed to readily interpret results. We designed a platform to easily access and summarize data about pathogen samples. The software includes a PostgreSQL database that captures metadata useful for disease outbreak investigations, and scripts for downloading and parsing data from NCBI BioSample and BioProject into the database. The software provides a user interface to query metadata and obtain standardized results in an exportable, tab-delimited format. To visually summarize results, the user interface provides a 2D histogram for user-selected metadata types and mapping of geolocated entries. The software is built on the LabKey data platform, an open-source data management platform, which enables developers to add functionalities. We demonstrate the use of the software in querying for a pathogen serovar and for genome sequence identifiers. This software enables users to create a local database for pathogen metadata, populate it with data from NCBI, easily query the data, and obtain visual summaries. Some of the components, such as the database, are modular and can be incorporated into other data platforms. The source code is freely available for download at https://github.com/wchangmitre/bioattribution .

Challenges to nurses' efforts of retrieving, documenting, and communicating patient care information.

PubMed

Keenan, Gail; Yakel, Elizabeth; Dunn Lopez, Karen; Tschannen, Dana; Ford, Yvonne B

2013-01-01

To examine information flow, a vital component of a patient's care and outcomes, in a sample of multiple hospital nursing units to uncover potential sources of error and opportunities for systematic improvement. This was a qualitative study of a sample of eight medical-surgical nursing units from four diverse hospitals in one US state. We conducted direct work observations of nursing staff's communication patterns for entire shifts (8 or 12 h) for a total of 200 h and gathered related documentation artifacts for analyses. Data were coded using qualitative content analysis procedures and then synthesized and organized thematically to characterize current practices. Three major themes emerged from the analyses, which represent serious vulnerabilities in the flow of patient care information during nurse hand-offs and to the entire interdisciplinary team across time and settings. The three themes are: (1) variation in nurse documentation and communication; (2) the absence of a centralized care overview in the patient's electronic health record, ie, easily accessible by the entire care team; and (3) rarity of interdisciplinary communication. The care information flow vulnerabilities are a catalyst for multiple types of serious and undetectable clinical errors. We have two major recommendations to address the gaps: (1) to standardize the format, content, and words used to document core information, such as the plan of care, and make this easily accessible to all team members; (2) to conduct extensive usability testing to ensure that tools in the electronic health record help the disconnected interdisciplinary team members to maintain a shared understanding of the patient's plan.

Challenges to nurses' efforts of retrieving, documenting, and communicating patient care information

PubMed Central

Yakel, Elizabeth; Dunn Lopez, Karen; Tschannen, Dana; Ford, Yvonne B

2013-01-01

Objective To examine information flow, a vital component of a patient's care and outcomes, in a sample of multiple hospital nursing units to uncover potential sources of error and opportunities for systematic improvement. Design This was a qualitative study of a sample of eight medical–surgical nursing units from four diverse hospitals in one US state. We conducted direct work observations of nursing staff's communication patterns for entire shifts (8 or 12 h) for a total of 200 h and gathered related documentation artifacts for analyses. Data were coded using qualitative content analysis procedures and then synthesized and organized thematically to characterize current practices. Results Three major themes emerged from the analyses, which represent serious vulnerabilities in the flow of patient care information during nurse hand-offs and to the entire interdisciplinary team across time and settings. The three themes are: (1) variation in nurse documentation and communication; (2) the absence of a centralized care overview in the patient's electronic health record, ie, easily accessible by the entire care team; and (3) rarity of interdisciplinary communication. Conclusion The care information flow vulnerabilities are a catalyst for multiple types of serious and undetectable clinical errors. We have two major recommendations to address the gaps: (1) to standardize the format, content, and words used to document core information, such as the plan of care, and make this easily accessible to all team members; (2) to conduct extensive usability testing to ensure that tools in the electronic health record help the disconnected interdisciplinary team members to maintain a shared understanding of the patient's plan. PMID:22822042

SLIMS--a user-friendly sample operations and inventory management system for genotyping labs.

PubMed

Van Rossum, Thea; Tripp, Ben; Daley, Denise

2010-07-15

We present the Sample-based Laboratory Information Management System (SLIMS), a powerful and user-friendly open source web application that provides all members of a laboratory with an interface to view, edit and create sample information. SLIMS aims to simplify common laboratory tasks with tools such as a user-friendly shopping cart for subjects, samples and containers that easily generates reports, shareable lists and plate designs for genotyping. Further key features include customizable data views, database change-logging and dynamically filled pre-formatted reports. Along with being feature-rich, SLIMS' power comes from being able to handle longitudinal data from multiple time-points and biological sources. This type of data is increasingly common from studies searching for susceptibility genes for common complex diseases that collect thousands of samples generating millions of genotypes and overwhelming amounts of data. LIMSs provide an efficient way to deal with this data while increasing accessibility and reducing laboratory errors; however, professional LIMS are often too costly to be practical. SLIMS gives labs a feasible alternative that is easily accessible, user-centrically designed and feature-rich. To facilitate system customization, and utilization for other groups, manuals have been written for users and developers. Documentation, source code and manuals are available at http://genapha.icapture.ubc.ca/SLIMS/index.jsp. SLIMS was developed using Java 1.6.0, JSPs, Hibernate 3.3.1.GA, DB2 and mySQL, Apache Tomcat 6.0.18, NetBeans IDE 6.5, Jasper Reports 3.5.1 and JasperSoft's iReport 3.5.1.

BamTools: a C++ API and toolkit for analyzing and managing BAM files.

PubMed

Barnett, Derek W; Garrison, Erik K; Quinlan, Aaron R; Strömberg, Michael P; Marth, Gabor T

2011-06-15

Analysis of genomic sequencing data requires efficient, easy-to-use access to alignment results and flexible data management tools (e.g. filtering, merging, sorting, etc.). However, the enormous amount of data produced by current sequencing technologies is typically stored in compressed, binary formats that are not easily handled by the text-based parsers commonly used in bioinformatics research. We introduce a software suite for programmers and end users that facilitates research analysis and data management using BAM files. BamTools provides both the first C++ API publicly available for BAM file support as well as a command-line toolkit. BamTools was written in C++, and is supported on Linux, Mac OSX and MS Windows. Source code and documentation are freely available at http://github.org/pezmaster31/bamtools.

Assemble worldwide biologists in a network construct a web services based architecture for bioinformatics.

PubMed

Tao, Yuan; Liu, Juan

2005-01-01

The Internet has already deflated our world of working and living into a very small scope, thus bringing out the concept of Earth Village, in which people could communicate and co-work though thousands' miles far away from each other. This paper describes a prototype, which is just like an Earth Lab for bioinformatics, based on Web services framework to build up a network architecture for bioinformatics research and for world wide biologists to easily implement enormous, complex processes, and effectively share and access computing resources and data, regardless of how heterogeneous the format of the data is and how decentralized and distributed these resources are around the world. A diminutive and simplified example scenario is given out to realize the prototype after that.

NGL Viewer: a web application for molecular visualization

PubMed Central

Rose, Alexander S.; Hildebrand, Peter W.

2015-01-01

The NGL Viewer (http://proteinformatics.charite.de/ngl) is a web application for the visualization of macromolecular structures. By fully adopting capabilities of modern web browsers, such as WebGL, for molecular graphics, the viewer can interactively display large molecular complexes and is also unaffected by the retirement of third-party plug-ins like Flash and Java Applets. Generally, the web application offers comprehensive molecular visualization through a graphical user interface so that life scientists can easily access and profit from available structural data. It supports common structural file-formats (e.g. PDB, mmCIF) and a variety of molecular representations (e.g. ‘cartoon, spacefill, licorice’). Moreover, the viewer can be embedded in other web sites to provide specialized visualizations of entries in structural databases or results of structure-related calculations. PMID:25925569

What can Natural Language Processing do for Clinical Decision Support?

PubMed Central

Demner-Fushman, Dina; Chapman, Wendy W.; McDonald, Clement J.

2009-01-01

Computerized Clinical Decision Support (CDS) aims to aid decision making of health care providers and the public by providing easily accessible health-related information at the point and time it is needed. Natural Language Processing (NLP) is instrumental in using free-text information to drive CDS, representing clinical knowledge and CDS interventions in standardized formats, and leveraging clinical narrative. The early innovative NLP research of clinical narrative was followed by a period of stable research conducted at the major clinical centers and a shift of mainstream interest to biomedical NLP. This review primarily focuses on the recently renewed interest in development of fundamental NLP methods and advances in the NLP systems for CDS. The current solutions to challenges posed by distinct sublanguages, intended user groups, and support goals are discussed. PMID:19683066

Wolf Testing: Open Source Testing Software

NASA Astrophysics Data System (ADS)

Braasch, P.; Gay, P. L.

2004-12-01

Wolf Testing is software for easily creating and editing exams. Wolf Testing allows the user to create an exam from a database of questions, view it on screen, and easily print it along with the corresponding answer guide. The questions can be multiple choice, short answer, long answer, or true and false varieties. This software can be accessed securely from any location, allowing the user to easily create exams from home. New questions, which can include associated pictures, can be added through a web-interface. After adding in questions, they can be edited, deleted, or duplicated into multiple versions. Long-term test creation is simplified, as you are able to quickly see what questions you have asked in the past and insert them, with or without editing, into future tests. All tests are archived in the database. Written in PHP and MySQL, this software can be installed on any UNIX / Linux platform, including Macintosh OS X. The secure interface keeps students out, and allows you to decide who can create tests and who can edit information already in the database. Tests can be output as either html with pictures or rich text without pictures, and there are plans to add PDF and MS Word formats as well. We would like to thank Dr. Wolfgang Rueckner and the Harvard University Science Center for providing incentive to start this project, computers and resources to complete this project, and inspiration for the project's name. We would also like to thank Dr. Ronald Newburgh for his assistance in beta testing.

OntologyWidget – a reusable, embeddable widget for easily locating ontology terms

PubMed Central

Beauheim, Catherine C; Wymore, Farrell; Nitzberg, Michael; Zachariah, Zachariah K; Jin, Heng; Skene, JH Pate; Ball, Catherine A; Sherlock, Gavin

2007-01-01

Background Biomedical ontologies are being widely used to annotate biological data in a computer-accessible, consistent and well-defined manner. However, due to their size and complexity, annotating data with appropriate terms from an ontology is often challenging for experts and non-experts alike, because there exist few tools that allow one to quickly find relevant ontology terms to easily populate a web form. Results We have produced a tool, OntologyWidget, which allows users to rapidly search for and browse ontology terms. OntologyWidget can easily be embedded in other web-based applications. OntologyWidget is written using AJAX (Asynchronous JavaScript and XML) and has two related elements. The first is a dynamic auto-complete ontology search feature. As a user enters characters into the search box, the appropriate ontology is queried remotely for terms that match the typed-in text, and the query results populate a drop-down list with all potential matches. Upon selection of a term from the list, the user can locate this term within a generic and dynamic ontology browser, which comprises the second element of the tool. The ontology browser shows the paths from a selected term to the root as well as parent/child tree hierarchies. We have implemented web services at the Stanford Microarray Database (SMD), which provide the OntologyWidget with access to over 40 ontologies from the Open Biological Ontology (OBO) website [1]. Each ontology is updated weekly. Adopters of the OntologyWidget can either use SMD's web services, or elect to rely on their own. Deploying the OntologyWidget can be accomplished in three simple steps: (1) install Apache Tomcat [2] on one's web server, (2) download and install the OntologyWidget servlet stub that provides access to the SMD ontology web services, and (3) create an html (HyperText Markup Language) file that refers to the OntologyWidget using a simple, well-defined format. Conclusion We have developed OntologyWidget, an easy-to-use ontology search and display tool that can be used on any web page by creating a simple html description. OntologyWidget provides a rapid auto-complete search function paired with an interactive tree display. We have developed a web service layer that communicates between the web page interface and a database of ontology terms. We currently store 40 of the ontologies from the OBO website [1], as well as a several others. These ontologies are automatically updated on a weekly basis. OntologyWidget can be used in any web-based application to take advantage of the ontologies we provide via web services or any other ontology that is provided elsewhere in the correct format. The full source code for the JavaScript and description of the OntologyWidget is available from . PMID:17854506

OntologyWidget - a reusable, embeddable widget for easily locating ontology terms.

PubMed

Beauheim, Catherine C; Wymore, Farrell; Nitzberg, Michael; Zachariah, Zachariah K; Jin, Heng; Skene, J H Pate; Ball, Catherine A; Sherlock, Gavin

2007-09-13

Biomedical ontologies are being widely used to annotate biological data in a computer-accessible, consistent and well-defined manner. However, due to their size and complexity, annotating data with appropriate terms from an ontology is often challenging for experts and non-experts alike, because there exist few tools that allow one to quickly find relevant ontology terms to easily populate a web form. We have produced a tool, OntologyWidget, which allows users to rapidly search for and browse ontology terms. OntologyWidget can easily be embedded in other web-based applications. OntologyWidget is written using AJAX (Asynchronous JavaScript and XML) and has two related elements. The first is a dynamic auto-complete ontology search feature. As a user enters characters into the search box, the appropriate ontology is queried remotely for terms that match the typed-in text, and the query results populate a drop-down list with all potential matches. Upon selection of a term from the list, the user can locate this term within a generic and dynamic ontology browser, which comprises the second element of the tool. The ontology browser shows the paths from a selected term to the root as well as parent/child tree hierarchies. We have implemented web services at the Stanford Microarray Database (SMD), which provide the OntologyWidget with access to over 40 ontologies from the Open Biological Ontology (OBO) website 1. Each ontology is updated weekly. Adopters of the OntologyWidget can either use SMD's web services, or elect to rely on their own. Deploying the OntologyWidget can be accomplished in three simple steps: (1) install Apache Tomcat 2 on one's web server, (2) download and install the OntologyWidget servlet stub that provides access to the SMD ontology web services, and (3) create an html (HyperText Markup Language) file that refers to the OntologyWidget using a simple, well-defined format. We have developed OntologyWidget, an easy-to-use ontology search and display tool that can be used on any web page by creating a simple html description. OntologyWidget provides a rapid auto-complete search function paired with an interactive tree display. We have developed a web service layer that communicates between the web page interface and a database of ontology terms. We currently store 40 of the ontologies from the OBO website 1, as well as a several others. These ontologies are automatically updated on a weekly basis. OntologyWidget can be used in any web-based application to take advantage of the ontologies we provide via web services or any other ontology that is provided elsewhere in the correct format. The full source code for the JavaScript and description of the OntologyWidget is available from http://smd.stanford.edu/ontologyWidget/.

Insert Modifications Improve Access to Artificial Red-Cockaded Woodpecker Next Cavities

Treesearch

John W. Edwards; Ernest E. Stevens; Charles A. Dachelet

1997-01-01

A designfor a modified, artificial Red-cockaded Woodpecker(Picoides borealis) cavity insert is presented. This modification allowed eggs and young to be inspected easily, removed, and replaced throughout the nesting period. Modifications to cavity inserts are best done before installation, but can be easily retrofitted in existing artificial cavities...

A Toolbox for Ab Initio 3-D Reconstructions in Single-particle Electron Microscopy

PubMed Central

Voss, Neil R; Lyumkis, Dmitry; Cheng, Anchi; Lau, Pick-Wei; Mulder, Anke; Lander, Gabriel C; Brignole, Edward J; Fellmann, Denis; Irving, Christopher; Jacovetty, Erica L; Leung, Albert; Pulokas, James; Quispe, Joel D; Winkler, Hanspeter; Yoshioka, Craig; Carragher, Bridget; Potter, Clinton S

2010-01-01

Structure determination of a novel macromolecular complex via single-particle electron microscopy depends upon overcoming the challenge of establishing a reliable 3-D reconstruction using only 2-D images. There are a variety of strategies that deal with this issue, but not all of them are readily accessible and straightforward to use. We have developed a “toolbox” of ab initio reconstruction techniques that provide several options for calculating 3-D volumes in an easily managed and tightly controlled work-flow that adheres to standard conventions and formats. This toolbox is designed to streamline the reconstruction process by removing the necessity for bookkeeping, while facilitating transparent data transfer between different software packages. It currently includes procedures for calculating ab initio reconstructions via random or orthogonal tilt geometry, tomograms, and common lines, all of which have been tested using the 50S ribosomal subunit. Our goal is that the accessibility of multiple independent reconstruction algorithms via this toolbox will improve the ease with which models can be generated, and provide a means of evaluating the confidence and reliability of the final reconstructed map. PMID:20018246

Integrated Data Capturing Requirements for 3d Semantic Modelling of Cultural Heritage: the Inception Protocol

NASA Astrophysics Data System (ADS)

Di Giulio, R.; Maietti, F.; Piaia, E.; Medici, M.; Ferrari, F.; Turillazzi, B.

2017-02-01

The generation of high quality 3D models can be still very time-consuming and expensive, and the outcome of digital reconstructions is frequently provided in formats that are not interoperable, and therefore cannot be easily accessed. This challenge is even more crucial for complex architectures and large heritage sites, which involve a large amount of data to be acquired, managed and enriched by metadata. In this framework, the ongoing EU funded project INCEPTION - Inclusive Cultural Heritage in Europe through 3D semantic modelling proposes a workflow aimed at the achievements of efficient 3D digitization methods, post-processing tools for an enriched semantic modelling, web-based solutions and applications to ensure a wide access to experts and non-experts. In order to face these challenges and to start solving the issue of the large amount of captured data and time-consuming processes in the production of 3D digital models, an Optimized Data Acquisition Protocol (DAP) has been set up. The purpose is to guide the processes of digitization of cultural heritage, respecting needs, requirements and specificities of cultural assets.

λ5-Phosphorus-Containing α-Diazo Compounds: A Valuable Tool for Accessing Phosphorus-Functionalized Molecules.

PubMed

Marinozzi, Maura; Pertusati, Fabrizio; Serpi, Michaela

2016-11-23

The compounds characterized by the presence of a λ 5 -phosphorus functionality at the α-position with respect to the diazo moiety, here referred to as λ 5 -phosphorus-containing α-diazo compounds (PCDCs), represent a vast class of extremely versatile reagents in organic chemistry and are particularly useful in the preparation of phosphonate- and phosphinoxide-functionalized molecules. Indeed, thanks to the high reactivity of the diazo moiety, PCDCs can be induced to undergo a wide variety of chemical transformations. Among them are carbon-hydrogen, as well as heteroatom-hydrogen insertion reactions, cyclopropanation, ylide formation, Wolff rearrangement, and cycloaddition reactions. PCDCs can be easily prepared from readily accessible precursors by a variety of different methods, such as diazotization, Bamford-Stevens-type elimination, and diazo transfer reactions. This evidence along with their relative stability and manageability make them appealing tools in organic synthesis. This Review aims to demonstrate the ongoing utility of PCDCs in the modern preparation of different classes of phosphorus-containing compounds, phosphonates, in particular. Furthermore, to address the lack of precedent collective papers, this Review also summarizes the methods for PCDCs preparation.

Visualizing Cloud Properties and Satellite Imagery: A Tool for Visualization and Information Integration

NASA Astrophysics Data System (ADS)

Chee, T.; Nguyen, L.; Smith, W. L., Jr.; Spangenberg, D.; Palikonda, R.; Bedka, K. M.; Minnis, P.; Thieman, M. M.; Nordeen, M.

2017-12-01

Providing public access to research products including cloud macro and microphysical properties and satellite imagery are a key concern for the NASA Langley Research Center Cloud and Radiation Group. This work describes a web based visualization tool and API that allows end users to easily create customized cloud product and satellite imagery, ground site data and satellite ground track information that is generated dynamically. The tool has two uses, one to visualize the dynamically created imagery and the other to provide access to the dynamically generated imagery directly at a later time. Internally, we leverage our practical experience with large, scalable application practices to develop a system that has the largest potential for scalability as well as the ability to be deployed on the cloud to accommodate scalability issues. We build upon NASA Langley Cloud and Radiation Group's experience with making real-time and historical satellite cloud product information, satellite imagery, ground site data and satellite track information accessible and easily searchable. This tool is the culmination of our prior experience with dynamic imagery generation and provides a way to build a "mash-up" of dynamically generated imagery and related kinds of information that are visualized together to add value to disparate but related information. In support of NASA strategic goals, our group aims to make as much scientific knowledge, observations and products available to the citizen science, research and interested communities as well as for automated systems to acquire the same information for data mining or other analytic purposes. This tool and the underlying API's provide a valuable research tool to a wide audience both as a standalone research tool and also as an easily accessed data source that can easily be mined or used with existing tools.

An event database for rotational seismology

NASA Astrophysics Data System (ADS)

Salvermoser, Johannes; Hadziioannou, Celine; Hable, Sarah; Chow, Bryant; Krischer, Lion; Wassermann, Joachim; Igel, Heiner

2016-04-01

The ring laser sensor (G-ring) located at Wettzell, Germany, routinely observes earthquake-induced rotational ground motions around a vertical axis since its installation in 2003. Here we present results from a recently installed event database which is the first that will provide ring laser event data in an open access format. Based on the GCMT event catalogue and some search criteria, seismograms from the ring laser and the collocated broadband seismometer are extracted and processed. The ObsPy-based processing scheme generates plots showing waveform fits between rotation rate and transverse acceleration and extracts characteristic wavefield parameters such as peak ground motions, noise levels, Love wave phase velocities and waveform coherence. For each event, these parameters are stored in a text file (json dictionary) which is easily readable and accessible on the website. The database contains >10000 events starting in 2007 (Mw>4.5). It is updated daily and therefore provides recent events at a time lag of max. 24 hours. The user interface allows to filter events for epoch, magnitude, and source area, whereupon the events are displayed on a zoomable world map. We investigate how well the rotational motions are compatible with the expectations from the surface wave magnitude scale. In addition, the website offers some python source code examples for downloading and processing the openly accessible waveforms.

Access to Success

ERIC Educational Resources Information Center

Brunken, Anna; Delly, Pamela

2011-01-01

Changes to education in Australia have seen new government legislations increasing educational pathways so students can more easily enter university, the aim being to increase participation. Now, many domestic students utilise various pathways to access university. Some have undertaken basic Further Education Diplomas, received subject credits,…

NASA PDS IMG: Accessing Your Planetary Image Data

NASA Astrophysics Data System (ADS)

Padams, J.; Grimes, K.; Hollins, G.; Lavoie, S.; Stanboli, A.; Wagstaff, K.

2018-04-01

The Planetary Data System Cartography and Imaging Sciences Node provides a number of tools and services to integrate the 700+ TB of image data so information can be correlated across missions, instruments, and data sets and easily accessed by the science community.

Breakthrough Science Enabled by Regular Access to Orbits Beyond Earth

NASA Astrophysics Data System (ADS)

Gorjian, V.

2018-02-01

Regular launches to the Deep Space Gateway (DSG) will enable smallsats to access orbits not currently easily available to low cost missions. These orbits will allow great new science, especially when using the DSG as an optical hub for downlink.

Making Behavior Change Interventions Available to Young African American Women: Development and Feasibility of an eHealth Lifestyle Program.

PubMed

Staffileno, Beth A; Tangney, Christy C; Fogg, Louis; Darmoc, Rebecca

2015-01-01

Less is known about young African American (AA) women, largely because the young are hard to reach. Traditional approaches to behavior changes interventions impose several challenges, especially for AA women at risk for developing hypertension. This feasibility study describes the process of transforming a face-to-face lifestyle change intervention into a Web-based platform (eHealth) accessible by iPads, iPhones, smartphones, and personal computers. Four sequential phases were conducted using elements of formative evaluation and quantitative analysis. A convenience sample of AA women, aged 18 to 45 years, with self-reported prehypertension and regular access to the Internet were eligible to participate. Eleven women involved in phase 1 expressed that they (1) currently use the Internet to retrieve health-related information, (2) prefer to use the Internet rather than face-to-face contact for nonserious conditions, (3) need convenience and easily accessible health-related interventions, and (4) are amenable to the idea of an eHealth lifestyle modification program. During phase 2, learning modules derived from printed manuals were adapted and compressed for a Web audience. The modules were designed to present evidence-based content but allowed for tailoring and individualization according to the needs of the target population. During phase 3, 8 women provided formative information concerning appeal and usability of the eHealth program in relation to delivery, visual quality, interactivity, and engagement. Phase 4 involved 8 women beta testing the 12-week program, with a 63% completion rate. Most of the women agreed that the program and screens opened with ease, the functions on the screens did what they were supposed to do, and the discussion board was easy to access. Program completion was greater for physical activity compared with dietary content. This study outlines a step-by-step process for transforming face-to-face content into a Web-based platform, which, importantly, can serve as a template for promoting other health behaviors.

Spatial data available on the web at http://mrdata.usgs.gov/

USGS Publications Warehouse

Johnson, Bruce

2002-01-01

Earth science information is important to decisionmakers who formulate public policy related to mineral resource sustainability, land stewardship, environmental hazards, the economy, and public health. To meet the growing demand for easily accessible data, the Mineral Resources Program has developed, in cooperation with other Federal and State agencies, an Internet-based, data-delivery system that allows interested customers worldwide to download accurate, up-to-date mineral resource-related data at any time. All data in the system are spatially located and customers with Internet access and a modern Web browser can easily produce maps having user-defined overlays for any region of interest.

Expectations, effect and experiences of an easily accessible self-management intervention for people with chronic pain: study protocol for a randomised controlled trial with embedded qualitative study.

PubMed

Nøst, Torunn Hatlen; Steinsbekk, Aslak; Bratås, Ola; Grønning, Kjersti

2016-07-18

People struggling with chronic pain may benefit from different types of non-pharmacological interventions such as self-management courses. Self-management courses aim to increase participants' skills and knowledge in managing chronic conditions. Community health-care services in Norway have increasingly established Healthy Life Centres (HLCs) to offer easily accessible interventions to people in need of support to better handle a life with chronic illness. The aim of this trial is to investigate the expectations, effect and experience of an easily accessible, group-based self-management course delivered at a HLC for people with chronic pain. This is an open pragmatic two-armed randomised controlled trial with an embedded qualitative study. The intervention is a self-management course comprising education, discussions, exchange of experiences between the participants, and physical movement exercises. The control group is offered a drop-in outdoor physical activity. The intervention period is 6 weeks. The primary outcome is patient activation measured by the patient activation measure (PAM). The secondary outcomes include measures of self-efficacy, pain and quality of life. Data will be collected at baseline, and after 3, 6 and 12 months. Using a mixed linear model, the number needed in each arm to achieve a power of 80 % becomes 55. To allow for dropout, the aim is to include 120 participants. Analysis will be done using mixed linear models. In the embedded qualitative study, we will perform semi-structured face-to-face interviews with a sample from both trial arms before randomisation and after 3 and 12 months. The topics elaborated will be motivation for participation and experiences with the activity related to possible changes in managing and coping with chronic pain. There is need for more knowledge on interventions delivering self-care support in an easily accessible way that aim to reach those in need of this kind of health service. This trial will produce important knowledge on the effect and the experiences of participants in such an easily accessible self-management course delivered in Norwegian public primary care. ClinicalTrials.gov: NCT02531282 . Registered on 21 August 2015.

Easily disassembled electrical connector for high voltage, high frequency connections

DOEpatents

Milner, Joseph R.

1994-01-01

An easily accessible electrical connector capable of rapid assembly and disassembly wherein a wide metal conductor sheet may be evenly contacted over the entire width of the conductor sheet by opposing surfaces on the connector which provide an even clamping pressure against opposite surfaces of the metal conductor sheet using a single threaded actuating screw.

Entomopathogen ID: a curated sequence resource for entomopathogenic fungi

USDA-ARS?s Scientific Manuscript database

We report the development of a publicly accessible, curated database of Hypocrealean entomopathogenic fungi sequence data. The goal is to provide a platform for users to easily access sequence data from reference strains. The database can be used to accurately identify unknown entomopathogenic fungi...

20. Perimeter acquisition radar building room #105, shockisolated platform for ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. Perimeter acquisition radar building room #105, shock-isolated platform for chillers is easily seen on the right - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

A Tool and Application Programming Interface for Browsing Historical Geostationary Satellite Data

NASA Astrophysics Data System (ADS)

Chee, T.; Nguyen, L.; Minnis, P.; Spangenberg, D.; Ayers, J.

2013-12-01

Providing access to information is a key concern for NASA Langley Research Center. We describe a tool and method that allows end users to easily browse and access information that is otherwise difficult to acquire and manipulate. The tool described has as its core the application-programming interface that is made available to the public. One goal of the tool is to provide a demonstration to end users so that they can use the enhanced imagery as an input into their own work flows. This project builds upon NASA Langley Cloud and Radiation Group's experience with making real-time and historical satellite imagery accessible and easily searchable. As we see the increasing use of virtual supply chains that provide additional value at each link there is value in making satellite imagery available through a simple access method as well as allowing users to browse and view that imagery as they need rather than in a manner most convenient for the data provider.

The Mark 3 data base handler

NASA Technical Reports Server (NTRS)

Ryan, J. W.; Ma, C.; Schupler, B. R.

1980-01-01

A data base handler which would act to tie Mark 3 system programs together is discussed. The data base handler is written in FORTRAN and is implemented on the Hewlett-Packard 21MX and the IBM 360/91. The system design objectives were to (1) provide for an easily specified method of data interchange among programs, (2) provide for a high level of data integrity, (3) accommodate changing requirments, (4) promote program accountability, (5) provide a single source of program constants, and (6) provide a central point for data archiving. The system consists of two distinct parts: a set of files existing on disk packs and tapes; and a set of utility subroutines which allow users to access the information in these files. Users never directly read or write the files and need not know the details of how the data are formatted in the files. To the users, the storage medium is format free. A user does need to know something about the sequencing of his data in the files but nothing about data in which he has no interest.

HYDRA : High-speed simulation architecture for precision spacecraft formation simulation

NASA Technical Reports Server (NTRS)

Martin, Bryan J.; Sohl, Garett.

2003-01-01

e Hierarchical Distributed Reconfigurable Architecture- is a scalable simulation architecture that provides flexibility and ease-of-use which take advantage of modern computation and communication hardware. It also provides the ability to implement distributed - or workstation - based simulations and high-fidelity real-time simulation from a common core. Originally designed to serve as a research platform for examining fundamental challenges in formation flying simulation for future space missions, it is also finding use in other missions and applications, all of which can take advantage of the underlying Object-Oriented structure to easily produce distributed simulations. Hydra automates the process of connecting disparate simulation components (Hydra Clients) through a client server architecture that uses high-level descriptions of data associated with each client to find and forge desirable connections (Hydra Services) at run time. Services communicate through the use of Connectors, which abstract messaging to provide single-interface access to any desired communication protocol, such as from shared-memory message passing to TCP/IP to ACE and COBRA. Hydra shares many features with the HLA, although providing more flexibility in connectivity services and behavior overriding.

The digital curriculum vitae.

PubMed

Galdino, Greg M; Gotway, Michael

2005-02-01

The curriculum vitae (CV) has been the traditional method for radiologists to illustrate their accomplishments in the field of medicine. Despite its presence in medicine as a standard, widely accepted means to describe one's professional career and its use for decades as an accomplice to most applications and interviews, there is relatively little written in the medical literature regarding the CV. Misrepresentation on medical students', residents', and fellows' applications has been reported. Using digital technology, CVs have the potential to be much more than printed words on paper and offers a solution to misrepresentation. Digital CVs may incorporate full-length articles, graphics, presentations, clinical images, and video. Common formats for digital CVs include CD-ROMs or DVD-ROMs containing articles (in Adobe Portable Document Format) and presentations (in Microsoft PowerPoint format) accompanying printed CVs, word processing documents with hyperlinks to articles and presentations either locally (on CD-ROMs or DVD-ROMs) or remotely (via the Internet), or hypertext markup language documents. Digital CVs afford the ability to provide more information that is readily accessible to those receiving and reviewing them. Articles, presentations, videos, images, and Internet links can be illustrated using standard file formats commonly available to all radiologists. They can be easily updated and distributed on an inexpensive media, such as a CD-ROM or DVD-ROM. With the availability of electronic articles, presentations, and information via the Internet, traditional paper CVs may soon be superseded by their electronic successors.

Assessing the psychosocial needs and program preferences of adolescents and young adults with cancer.

PubMed

Barakat, Lamia P; Galtieri, Liana R; Szalda, Dava; Schwartz, Lisa A

2016-02-01

Adolescents and young adults (AYA) are a developmentally distinct cancer group, vulnerable to psychosocial late effects and with a range of unmet psychosocial needs. We sought to better understand psychosocial care needs and program preferences to inform development of more easily accessible and effective AYA psychosocial programs. AYA on and off treatment for cancer (n = 111, ages 12-25 years) were approached during an outpatient clinic visit and completed a survey as part of a quality improvement initiative. The survey comprised an open-ended question on challenges related to cancer and treatment and closed-ended questions on access to and preference for various services and programs. Qualitative analyses were used to summarize themes for most significant challenges, and descriptive statistics were used for closed-ended questions. Most common themes for challenges included treatments and associated physical changes, barriers to pursuit of academic/vocational goals, and social isolation. For preferred program focus, AYA ranked highest increasing strength and endurance/reintegration into sports and dealing with physical changes resulting from treatment. AYA's preferred modalities for program delivery were one-on-one/in person and message boards/Facebook. Most of the sample indicated that lack of awareness prevented their accessing available programs. New information was identified that can be used to address access barriers and to offer AYA psychosocial programs in formats that might improve interest and accessibility. Ongoing evaluation of AYA psychosocial programs is recommended to determine acceptability, feasibility, and effectiveness to meet the evolving needs of AYA patients with cancer.

Cell-tower deployment of counter-sniper sensors

NASA Astrophysics Data System (ADS)

Storch, Michael T.

2004-09-01

Cellular telephone antenna towers are evaluated as sites for rapid, effective & efficient deployment of counter-sniper sensors, especially in urban environments. They are expected to offer a suitable density, excellent LOS, and a generally limited variety of known or readily-characterized mechanical interfaces. Their precise locations are easily mapped in advance of deployment, are easily accessible by ground and air, and are easily spotted by deployment teams in real-time. We survey issues of EMI & RFI, susceptibility to denial & ambush in military scenarios, and the impact of trends in cell tower design & construction.

Making On-Line Science Course Materials Easily Translatable and Accessible Worldwide: Challenges and Solutions

ERIC Educational Resources Information Center

Adams, Wendy K.; Alhadlaq, Hisham; Malley, Christopher V.; Perkins, Katherine K.; Olson, Jonathan; Alshaya, Fahad; Alabdulkareem, Saleh; Wieman, Carl E.

2012-01-01

The PhET Interactive Simulations Project partnered with the Excellence Research Center of Science and Mathematics Education at King Saud University with the joint goal of making simulations useable worldwide. One of the main challenges of this partnership is to make PhET simulations and the website easily translatable into any language. The PhET…

Easily disassembled electrical connector for high voltage, high frequency connections

DOEpatents

Milner, J.R.

1994-05-10

An easily accessible electrical connector capable of rapid assembly and disassembly is described wherein a wide metal conductor sheet may be evenly contacted over the entire width of the conductor sheet by opposing surfaces on the connector which provide an even clamping pressure against opposite surfaces of the metal conductor sheet using a single threaded actuating screw. 13 figures.

BamTools: a C++ API and toolkit for analyzing and managing BAM files

PubMed Central

Barnett, Derek W.; Garrison, Erik K.; Quinlan, Aaron R.; Strömberg, Michael P.; Marth, Gabor T.

2011-01-01

Motivation: Analysis of genomic sequencing data requires efficient, easy-to-use access to alignment results and flexible data management tools (e.g. filtering, merging, sorting, etc.). However, the enormous amount of data produced by current sequencing technologies is typically stored in compressed, binary formats that are not easily handled by the text-based parsers commonly used in bioinformatics research. Results: We introduce a software suite for programmers and end users that facilitates research analysis and data management using BAM files. BamTools provides both the first C++ API publicly available for BAM file support as well as a command-line toolkit. Availability: BamTools was written in C++, and is supported on Linux, Mac OSX and MS Windows. Source code and documentation are freely available at http://github.org/pezmaster31/bamtools. Contact: barnetde@bc.edu PMID:21493652

GRACKLE: a chemistry and cooling library for astrophysics

NASA Astrophysics Data System (ADS)

Smith, Britton D.; Bryan, Greg L.; Glover, Simon C. O.; Goldbaum, Nathan J.; Turk, Matthew J.; Regan, John; Wise, John H.; Schive, Hsi-Yu; Abel, Tom; Emerick, Andrew; O'Shea, Brian W.; Anninos, Peter; Hummels, Cameron B.; Khochfar, Sadegh

2017-04-01

We present the GRACKLE chemistry and cooling library for astrophysical simulations and models. GRACKLE provides a treatment of non-equilibrium primordial chemistry and cooling for H, D and He species, including H2 formation on dust grains; tabulated primordial and metal cooling; multiple ultraviolet background models; and support for radiation transfer and arbitrary heat sources. The library has an easily implementable interface for simulation codes written in C, C++ and FORTRAN as well as a PYTHON interface with added convenience functions for semi-analytical models. As an open-source project, GRACKLE provides a community resource for accessing and disseminating astrochemical data and numerical methods. We present the full details of the core functionality, the simulation and PYTHON interfaces, testing infrastructure, performance and range of applicability. GRACKLE is a fully open-source project and new contributions are welcome.

Arrayed antibody library technology for therapeutic biologic discovery.

PubMed

Bentley, Cornelia A; Bazirgan, Omar A; Graziano, James J; Holmes, Evan M; Smider, Vaughn V

2013-03-15

Traditional immunization and display antibody discovery methods rely on competitive selection amongst a pool of antibodies to identify a lead. While this approach has led to many successful therapeutic antibodies, targets have been limited to proteins which are easily purified. In addition, selection driven discovery has produced a narrow range of antibody functionalities focused on high affinity antagonism. We review the current progress in developing arrayed protein libraries for screening-based, rather than selection-based, discovery. These single molecule per microtiter well libraries have been screened in multiplex formats against both purified antigens and directly against targets expressed on the cell surface. This facilitates the discovery of antibodies against therapeutically interesting targets (GPCRs, ion channels, and other multispanning membrane proteins) and epitopes that have been considered poorly accessible to conventional discovery methods. Copyright © 2013. Published by Elsevier Inc.

SpectralNET – an application for spectral graph analysis and visualization

PubMed Central

Forman, Joshua J; Clemons, Paul A; Schreiber, Stuart L; Haggarty, Stephen J

2005-01-01

Background Graph theory provides a computational framework for modeling a variety of datasets including those emerging from genomics, proteomics, and chemical genetics. Networks of genes, proteins, small molecules, or other objects of study can be represented as graphs of nodes (vertices) and interactions (edges) that can carry different weights. SpectralNET is a flexible application for analyzing and visualizing these biological and chemical networks. Results Available both as a standalone .NET executable and as an ASP.NET web application, SpectralNET was designed specifically with the analysis of graph-theoretic metrics in mind, a computational task not easily accessible using currently available applications. Users can choose either to upload a network for analysis using a variety of input formats, or to have SpectralNET generate an idealized random network for comparison to a real-world dataset. Whichever graph-generation method is used, SpectralNET displays detailed information about each connected component of the graph, including graphs of degree distribution, clustering coefficient by degree, and average distance by degree. In addition, extensive information about the selected vertex is shown, including degree, clustering coefficient, various distance metrics, and the corresponding components of the adjacency, Laplacian, and normalized Laplacian eigenvectors. SpectralNET also displays several graph visualizations, including a linear dimensionality reduction for uploaded datasets (Principal Components Analysis) and a non-linear dimensionality reduction that provides an elegant view of global graph structure (Laplacian eigenvectors). Conclusion SpectralNET provides an easily accessible means of analyzing graph-theoretic metrics for data modeling and dimensionality reduction. SpectralNET is publicly available as both a .NET application and an ASP.NET web application from . Source code is available upon request. PMID:16236170

SpectralNET--an application for spectral graph analysis and visualization.

PubMed

Forman, Joshua J; Clemons, Paul A; Schreiber, Stuart L; Haggarty, Stephen J

2005-10-19

Graph theory provides a computational framework for modeling a variety of datasets including those emerging from genomics, proteomics, and chemical genetics. Networks of genes, proteins, small molecules, or other objects of study can be represented as graphs of nodes (vertices) and interactions (edges) that can carry different weights. SpectralNET is a flexible application for analyzing and visualizing these biological and chemical networks. Available both as a standalone .NET executable and as an ASP.NET web application, SpectralNET was designed specifically with the analysis of graph-theoretic metrics in mind, a computational task not easily accessible using currently available applications. Users can choose either to upload a network for analysis using a variety of input formats, or to have SpectralNET generate an idealized random network for comparison to a real-world dataset. Whichever graph-generation method is used, SpectralNET displays detailed information about each connected component of the graph, including graphs of degree distribution, clustering coefficient by degree, and average distance by degree. In addition, extensive information about the selected vertex is shown, including degree, clustering coefficient, various distance metrics, and the corresponding components of the adjacency, Laplacian, and normalized Laplacian eigenvectors. SpectralNET also displays several graph visualizations, including a linear dimensionality reduction for uploaded datasets (Principal Components Analysis) and a non-linear dimensionality reduction that provides an elegant view of global graph structure (Laplacian eigenvectors). SpectralNET provides an easily accessible means of analyzing graph-theoretic metrics for data modeling and dimensionality reduction. SpectralNET is publicly available as both a .NET application and an ASP.NET web application from http://chembank.broad.harvard.edu/resources/. Source code is available upon request.

International Space Station Mechanisms and Maintenance Flight Control Documentation and Training Development

NASA Technical Reports Server (NTRS)

Daugherty, Colin C.

2010-01-01

International Space Station (ISS) crew and flight controller training documentation is used to aid in training operations. The Generic Simulations References SharePoint (Gen Sim) site is a database used as an aid during flight simulations. The Gen Sim site is used to make individual mission segment timelines, data, and flight information easily accessible to instructors. The Waste and Hygiene Compartment (WHC) training schematic includes simple and complex fluid schematics, as well as overall hardware locations. It is used as a teaching aid during WHC lessons for both ISS crew and flight controllers. ISS flight control documentation is used to support all aspects of ISS mission operations. The Quick Look Database and Consolidated Tool Page are imagery-based references used in real-time to help the Operations Support Officer (OSO) find data faster and improve discussions with the Flight Director and Capsule Communicator (CAPCOM). A Quick Look page was created for the Permanent Multipurpose Module (PMM) by locating photos of the module interior, labeling specific hardware, and organizing them in schematic form to match the layout of the PMM interior. A Tool Page was created for the Maintenance Work Area (MWA) by gathering images, detailed drawings, safety information, procedures, certifications, demonstration videos, and general facts of each MWA component and displaying them in an easily accessible and consistent format. Participation in ISS mechanisms and maintenance lessons, mission simulation On-the-Job Training (OJT), and real-time flight OJT was used as an opportunity to train for day-to-day operations as an OSO, as well as learn how to effectively respond to failures and emergencies during mission simulations and real-time flight operations.

Customizable tool for ecological data entry, assessment, monitoring, and interpretation

USDA-ARS?s Scientific Manuscript database

The Database for Inventory, Monitoring and Assessment (DIMA) is a highly customizable tool for data entry, assessment, monitoring, and interpretation. DIMA is a Microsoft Access database that can easily be used without Access knowledge and is available at no cost. Data can be entered for common, nat...

Mobile Learning and Achievement Goal Orientation Profiles

ERIC Educational Resources Information Center

Asplund, Minna

2014-01-01

Students with different achievement goal orientations have different approaches towards learning and studying. There is a widespread interest to find an easy access into learning spaces for those students who have low motivation with fear of failure and academic withdrawal. Mobile learning offers an easily accessible chance with low threshold to…

Development and applications of the EntomopathogenID MLSA database for use in agricultural systems

USDA-ARS?s Scientific Manuscript database

The current study reports the development and application of a publicly accessible, curated database of Hypocrealean entomopathogenic fungi sequence data. The goal was to provide a platform for users to easily access sequence data from reference strains. The database can be used to accurately identi...

CM-DataONE: A Framework for collaborative analysis of climate model output

NASA Astrophysics Data System (ADS)

Xu, Hao; Bai, Yuqi; Li, Sha; Dong, Wenhao; Huang, Wenyu; Xu, Shiming; Lin, Yanluan; Wang, Bin

2015-04-01

CM-DataONE is a distributed collaborative analysis framework for climate model data which aims to break through the data access barriers of increasing file size and to accelerate research process. As data size involved in project such as the fifth Coupled Model Intercomparison Project (CMIP5) has reached petabytes, conventional methods for analysis and diagnosis of model outputs have been rather time-consuming and redundant. CM-DataONE is developed for data publishers and researchers from relevant areas. It can enable easy access to distributed data and provide extensible analysis functions based on tools such as NCAR Command Language, NetCDF Operators (NCO) and Climate Data Operators (CDO). CM-DataONE can be easily installed, configured, and maintained. The main web application has two separate parts which communicate with each other through APIs based on HTTP protocol. The analytic server is designed to be installed in each data node while a data portal can be configured anywhere and connect to a nearest node. Functions such as data query, analytic task submission, status monitoring, visualization and product downloading are provided to end users by data portal. Data conform to CMIP5 Model Output Format in each peer node can be scanned by the server and mapped to a global information database. A scheduler included in the server is responsible for task decomposition, distribution and consolidation. Analysis functions are always executed where data locate. Analysis function package included in the server has provided commonly used functions such as EOF analysis, trend analysis and time series. Functions are coupled with data by XML descriptions and can be easily extended. Various types of results can be obtained by users for further studies. This framework has significantly decreased the amount of data to be transmitted and improved efficiency in model intercomparison jobs by supporting online analysis and multi-node collaboration. To end users, data query is therefore accelerated and the size of data to be downloaded is reduced. Methodology can be easily shared among scientists, avoiding unnecessary replication. Currently, a prototype of CM-DataONE has been deployed on two data nodes of Tsinghua University.

Neopterin formation and tryptophan degradation by a human myelomonocytic cell line (THP-1) upon cytokine treatment.

PubMed

Werner-Felmayer, G; Werner, E R; Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H

1990-05-15

Determination of neopterin [D-erythro-6-(1',2',3'-trihydroxypropyl)pterin] in body fluids is a powerful diagnostic tool in a variety of diseases in which activation of cellular immune mechanisms is involved, such as certain malignancies, allograft rejection, and autoimmune and infectious diseases. In vitro, neopterin is released into the supernatant by peripheral blood-derived monocytes/macrophages upon stimulation with gamma-interferon. In parallel, cleavage of tryptophan by indoleamine 2,3-dioxygenase is induced. We report here that the human myelomonocytic cell line THP-1 forms neopterin and degrades tryptophan upon treatment with gamma-interferon. Like in macrophages alpha-interferon and beta-interferon induce these pathways only to a much smaller degree. The action of interferons is enhanced by cotreatment with tumor necrosis factor alpha, lipopolysaccharide, or dexamethasone. gamma-Interferon-induced neopterin formation and indoleamine 2,3-dioxygenase activity are increased by raising extracellular tryptophan concentrations. The pattern of intracellularly formed pteridines upon stimulation with gamma-interferon shows the unique characteristics of human monocytes/macrophages. Neopterin, monapterin, and biopterin are produced in a 50:2:1 ratio. Thus, the THP-1 cell line provides a permanent, easily accessible in vitro system for studying the induction and mechanism of neopterin formation.

Topological Landscapes: A Terrain Metaphor for ScientificData

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weber, Gunther H.; Bremer, Peer-Timo; Pascucci, Valerio

2007-08-01

Scientific visualization and illustration tools are designed to help people understand the structure and complexity of scientific data with images that are as informative and intuitive as possible. In this context, the use of metaphors plays an important role, since they make complex information easily accessible by using commonly known concepts. In this paper we propose a new metaphor, called 'Topological Landscapes', which facilitates understanding the topological structure of scalar functions. The basic idea is to construct a terrain with the same topology as a given dataset and to display the terrain as an easily understood representation of the actualmore » input data. In this projection from an n-dimensional scalar function to a two-dimensional (2D) model we preserve function values of critical points, the persistence (function span) of topological features, and one possible additional metric property (in our examples volume). By displaying this topologically equivalent landscape together with the original data we harness the natural human proficiency in understanding terrain topography and make complex topological information easily accessible.« less

An AAA-DDD triply hydrogen-bonded complex easily accessible for supramolecular polymers.

PubMed

Han, Yi-Fei; Chen, Wen-Qiang; Wang, Hong-Bo; Yuan, Ying-Xue; Wu, Na-Na; Song, Xiang-Zhi; Yang, Lan

2014-12-15

For a complementary hydrogen-bonded complex, when every hydrogen-bond acceptor is on one side and every hydrogen-bond donor is on the other, all secondary interactions are attractive and the complex is highly stable. AAA-DDD (A=acceptor, D=donor) is considered to be the most stable among triply hydrogen-bonded sequences. The easily synthesized and further derivatized AAA-DDD system is very desirable for hydrogen-bonded functional materials. In this case, AAA and DDD, starting from 4-methoxybenzaldehyde, were synthesized with the Hantzsch pyridine synthesis and Friedländer annulation reaction. The association constant determined by fluorescence titration in chloroform at room temperature is 2.09×10(7)  M(-1) . The AAA and DDD components are not coplanar, but form a V shape in the solid state. Supramolecular polymers based on AAA-DDD triply hydrogen bonded have also been developed. This work may make AAA-DDD triply hydrogen-bonded sequences easily accessible for stimuli-responsive materials. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

CRISPR-Cas9-Mediated Genome Editing and Transcriptional Control in Yarrowia lipolytica.

PubMed

Schwartz, Cory; Wheeldon, Ian

2018-01-01

The discovery and adaptation of RNA-guided nucleases has resulted in the rapid development of efficient, scalable, and easily accessible synthetic biology tools for targeted genome editing and transcriptional control. In these systems, for example CRISPR-Cas9 from Streptococcus pyogenes, a protein with nuclease activity is targeted to a specific nucleotide sequence by a short RNA molecule, whereupon binding it cleaves the targeted nucleotide strand. To extend this genome-editing ability to the industrially important oleaginous yeast Yarrowia lipolytica, we developed a set of easily usable and effective CRISPR-Cas9 episomal vectors. In this protocols chapter, we first present a method by which arbitrary protein-coding genes can be disrupted via indel formation after CRISPR-Cas9 targeting. A second method demonstrates how the same CRISPR-Cas9 system can be used to induce markerless gene cassette integration into the genome by inducing homologous recombination after DNA cleavage by Cas9. Finally, we describe how a catalytically inactive form of Cas9 fused to a transcriptional repressor can be used to control transcription of native genes in Y. lipolytica. The CRISPR-Cas9 tools and strategies described here greatly increase the types of genome editing and transcriptional control that can be achieved in Y. lipolytica, and promise to facilitate more advanced engineering of this important oleaginous host.

PASMet: a web-based platform for prediction, modelling and analyses of metabolic systems

PubMed Central

Sriyudthsak, Kansuporn; Mejia, Ramon Francisco; Arita, Masanori; Hirai, Masami Yokota

2016-01-01

PASMet (Prediction, Analysis and Simulation of Metabolic networks) is a web-based platform for proposing and verifying mathematical models to understand the dynamics of metabolism. The advantages of PASMet include user-friendliness and accessibility, which enable biologists and biochemists to easily perform mathematical modelling. PASMet offers a series of user-functions to handle the time-series data of metabolite concentrations. The functions are organised into four steps: (i) Prediction of a probable metabolic pathway and its regulation; (ii) Construction of mathematical models; (iii) Simulation of metabolic behaviours; and (iv) Analysis of metabolic system characteristics. Each function contains various statistical and mathematical methods that can be used independently. Users who may not have enough knowledge of computing or programming can easily and quickly analyse their local data without software downloads, updates or installations. Users only need to upload their files in comma-separated values (CSV) format or enter their model equations directly into the website. Once the time-series data or mathematical equations are uploaded, PASMet automatically performs computation on server-side. Then, users can interactively view their results and directly download them to their local computers. PASMet is freely available with no login requirement at http://pasmet.riken.jp/ from major web browsers on Windows, Mac and Linux operating systems. PMID:27174940

NG6: Integrated next generation sequencing storage and processing environment.

PubMed

Mariette, Jérôme; Escudié, Frédéric; Allias, Nicolas; Salin, Gérald; Noirot, Céline; Thomas, Sylvain; Klopp, Christophe

2012-09-09

Next generation sequencing platforms are now well implanted in sequencing centres and some laboratories. Upcoming smaller scale machines such as the 454 junior from Roche or the MiSeq from Illumina will increase the number of laboratories hosting a sequencer. In such a context, it is important to provide these teams with an easily manageable environment to store and process the produced reads. We describe a user-friendly information system able to manage large sets of sequencing data. It includes, on one hand, a workflow environment already containing pipelines adapted to different input formats (sff, fasta, fastq and qseq), different sequencers (Roche 454, Illumina HiSeq) and various analyses (quality control, assembly, alignment, diversity studies,…) and, on the other hand, a secured web site giving access to the results. The connected user will be able to download raw and processed data and browse through the analysis result statistics. The provided workflows can easily be modified or extended and new ones can be added. Ergatis is used as a workflow building, running and monitoring system. The analyses can be run locally or in a cluster environment using Sun Grid Engine. NG6 is a complete information system designed to answer the needs of a sequencing platform. It provides a user-friendly interface to process, store and download high-throughput sequencing data.

Checklist for Change.

ERIC Educational Resources Information Center

Sills, Angelyn C.

1995-01-01

Describes a straightforward, workable strategy that involves a teacher checklist and short individual or student group conferences, with the goal of academic or behavioral improvements. Teachers can easily tick off marks on the checklist and return the form to the counselor; additionally, students can easily understand the format of the checklist.…

High-Resolution Scanning Electron Microscopy and Immuno-Gold Labeling of the Nuclear Lamina and Nuclear Pore Complex.

PubMed

Goldberg, Martin W

2016-01-01

Scanning electron microscopy (SEM) is a technique used to image surfaces. Field emission SEMs (feSEMs) can resolve structures that are ~0.5-1.5 nm apart. FeSEM, therefore is a useful technique for imaging molecular structures that exist at surfaces such as membranes. The nuclear envelope consists of four membrane surfaces, all of which may be accessible for imaging. Imaging of the cytoplasmic face of the outer membrane gives information about ribosomes and cytoskeletal attachments, as well as details of the cytoplasmic peripheral components of the nuclear pore complex, and is the most easily accessed surface. The nucleoplasmic face of the inner membrane is easily accessible in some cells, such as amphibian oocytes, giving valuable details about the organization of the nuclear lamina and how it interacts with the nuclear pore complexes. The luminal faces of both membranes are difficult to access, but may be exposed by various fracturing techniques. Protocols are presented here for the preparation, labeling, and feSEM imaging of Xenopus laevis oocyte nuclear envelopes.

Extension of the sasCIF format and its applications for data processing and deposition

DOE PAGES

Kachala, Michael; Westbrook, John; Svergun, Dmitri

2016-02-01

Recent advances in small-angle scattering (SAS) experimental facilities and data analysis methods have prompted a dramatic increase in the number of users and of projects conducted, causing an upsurge in the number of objects studied, experimental data available and structural models generated. To organize the data and models and make them accessible to the community, the Task Forces on SAS and hybrid methods for the International Union of Crystallography and the Worldwide Protein Data Bank envisage developing a federated approach to SAS data and model archiving. Within the framework of this approach, the existing databases may exchange information and providemore » independent but synchronized entries to users. At present, ways of exchanging information between the various SAS databases are not established, leading to possible duplication and incompatibility of entries, and limiting the opportunities for data-driven research for SAS users. In this work, a solution is developed to resolve these issues and provide a universal exchange format for the community, based on the use of the widely adopted crystallographic information framework (CIF). The previous version of the sasCIF format, implemented as an extension of the core CIF dictionary, has been available since 2000 to facilitate SAS data exchange between laboratories. The sasCIF format has now been extended to describe comprehensively the necessary experimental information, results and models, including relevant metadata for SAS data analysis and for deposition into a database. Processing tools for these files (sasCIFtools) have been developed, and these are available both as standalone open-source programs and integrated into the SAS Biological Data Bank, allowing the export and import of data entries as sasCIF files. Software modules to save the relevant information directly from beamline data-processing pipelines in sasCIF format are also developed. Lastly, this update of sasCIF and the relevant tools are an important step in the standardization of the way SAS data are presented and exchanged, to make the results easily accessible to users and to promote further the application of SAS in the structural biology community.« less

An evaluation of the process and initial impact of disseminating a nursing e-thesis.

PubMed

Macduff, Colin

2009-05-01

This paper is a report of a study conducted to evaluate product, process and outcome aspects of the dissemination of a nursing PhD thesis via an open-access electronic institutional repository. Despite the growth of university institutional repositories which make theses easily accessible via the world wide web, nursing has been very slow to evaluate related processes and outcomes. Drawing on Stake's evaluation research methods, a case study design was adopted. The case is described using a four-phase structure within which key aspects of process and impact are reflexively analysed. In the conceptualization/re-conceptualization phase, fundamental questions about the purpose, format and imagined readership for a published nursing PhD were considered. In the preparation phase, seven key practical processes were identified that are likely to be relevant to most e-theses. In the dissemination phase email invitations were primarily used to invite engagement. The evaluation phase involved quantitative indicators of initial impact, such as page viewing and download statistics and qualitative feedback on processes and product. Analysis of process and impact elements of e-thesis dissemination is likely to have more than intrinsic value. The advent of e-theses housed in web-based institutional repositories has the potential to transform thesis access and use. It also offers potential to transform the nature and scope of thesis production and dissemination. Nursing scholars can exploit and evaluate such opportunities.

Enhancing Discovery, Search, and Access of NASA Hydrological Data by Leveraging GEOSS

NASA Technical Reports Server (NTRS)

Teng, William L.

2015-01-01

An ongoing NASA-funded project has removed a longstanding barrier to accessing NASA data (i.e., accessing archived time-step array data as point-time series) for selected variables of the North American and Global Land Data Assimilation Systems (NLDAS and GLDAS, respectively) and other EOSDIS (Earth Observing System Data Information System) data sets (e.g., precipitation, soil moisture). These time series (data rods) are pre-generated. Data rods Web services are accessible through the CUAHSI Hydrologic Information System (HIS) and the Goddard Earth Sciences Data and Information Services Center (GES DISC) but are not easily discoverable by users of other non-NASA data systems. The Global Earth Observation System of Systems (GEOSS) is a logical mechanism for providing access to the data rods. An ongoing GEOSS Water Services project aims to develop a distributed, global registry of water data, map, and modeling services cataloged using the standards and procedures of the Open Geospatial Consortium and the World Meteorological Organization. The ongoing data rods project has demonstrated the feasibility of leveraging the GEOSS infrastructure to help provide access to time series of model grid information or grids of information over a geographical domain for a particular time interval. A recently-begun, related NASA-funded ACCESS-GEOSS project expands on these prior efforts. Current work is focused on both improving the performance of the generation of on-the-fly (OTF) data rods and the Web interfaces from which users can easily discover, search, and access NASA data.

DISTRIBUTED STRUCTURE-SEARCHABLE TOXICITY ...

EPA Pesticide Factsheets

The ability to assess the potential genotoxicity, carcinogenicity, or other toxicity of pharmaceutical or industrial chemicals based on chemical structure information is a highly coveted and shared goal of varied academic, commercial, and government regulatory groups. These diverse interests often employ different approaches and have different criteria and use for toxicity assessments, but they share a need for unrestricted access to existing public toxicity data linked with chemical structure information. Currently, there exists no central repository of toxicity information, commercial or public, that adequately meets the data requirements for flexible analogue searching, SAR model development, or building of chemical relational databases (CRD). The Distributed Structure-Searchable Toxicity (DSSTox) Public Database Network is being proposed as a community-supported, web-based effort to address these shared needs of the SAR and toxicology communities. The DSSTox project has the following major elements: 1) to adopt and encourage the use of a common standard file format (SDF) for public toxicity databases that includes chemical structure, text and property information, and that can easily be imported into available CRD applications; 2) to implement a distributed source approach, managed by a DSSTox Central Website, that will enable decentralized, free public access to structure-toxicity data files, and that will effectively link knowledgeable toxicity data s

The benefits of convergence.

PubMed

Chang, Gee-Kung; Cheng, Lin

2016-03-06

A multi-tier radio access network (RAN) combining the strength of fibre-optic and radio access technologies employing adaptive microwave photonics interfaces and radio-over-fibre (RoF) techniques is envisioned for future heterogeneous wireless communications. All-band radio spectrum from 0.1 to 100 GHz will be used to deliver wireless services with high capacity, high link speed and low latency. The multi-tier RAN will improve the cell-edge performance in an integrated heterogeneous environment enabled by fibre-wireless integration and networking for mobile fronthaul/backhaul, resource sharing and all-layer centralization of multiple standards with different frequency bands and modulation formats. In essence, this is a 'no-more-cells' architecture in which carrier aggregation among multiple frequency bands can be easily achieved with seamless handover between cells. In this way, current and future mobile network standards such as 4G and 5G can coexist with optimized and continuous cell coverage using multi-tier RoF regardless of the underlying network topology or protocol. In terms of users' experience, the future-proof approach achieves the goals of system capacity, link speed, latency and continuous heterogeneous cell coverage while overcoming the bandwidth crunch in next-generation communication networks. © 2016 The Author(s).

Effect of Redox “Non-Innocent” Linker on the Catalytic Activity of Copper-Catecholate-Decorated Metal–Organic Frameworks

DOE PAGES

Zhang, Xuan; Vermeulen, Nicolaas A.; Huang, Zhiyuan; ...

2017-12-26

Two new UiO-68 type of Zr-MOFs featuring redox non-innocent catechol-based linkers of different redox activities have been synthesized through a de novo mixed-linker strategy. Also, metalation of the MOFs with Cu(II) precursors triggers the reduction of Cu(II) by the phenyl-catechol groups to Cu(I) with the concomitant formation of semiquinone radicals as evidenced by EPR and XPS characterization. The MOF-supported catalysts are selective toward the allylic oxidation of cyclohexene and it is found that the presence of in situ-generated Cu(I) species exhibits enhanced catalytic activity as compared to a similar MOF with Cu(II) metalated naphthalenyl-dihydroxy groups. Here, this work unveils themore » importance of metal-support redox interactions in the catalytic activity of MOF-supported catalysts which are not easily accessible in traditional metal oxide supports.« less

A virtual observatory for photoionized nebulae: the Mexican Million Models database (3MdB).

NASA Astrophysics Data System (ADS)

Morisset, C.; Delgado-Inglada, G.; Flores-Fajardo, N.

2015-04-01

Photoionization models obtained with numerical codes are widely used to study the physics of the interstellar medium (planetary nebulae, HII regions, etc). Grids of models are performed to understand the effects of the different parameters used to describe the regions on the observables (mainly emission line intensities). Most of the time, only a small part of the computed results of such grids are published, and they are sometimes hard to obtain in a user-friendly format. We present here the Mexican Million Models dataBase (3MdB), an effort to resolve both of these issues in the form of a database of photoionization models, easily accessible through the MySQL protocol, and containing a lot of useful outputs from the models, such as the intensities of 178 emission lines, the ionic fractions of all the ions, etc. Some examples of the use of the 3MdB are also presented.

Concretions in Exhumed Channels Near Hanksville Utah: Implications for Mars

NASA Technical Reports Server (NTRS)

Clarke, Jonathan; Stoker, Carol R.

2011-01-01

The landscape near Hanksville, Utah, contains a diversity of Mars analogue features. These included segmented and inverted anatasomosing palaeochannels exhumed from the Late Jurassic Brushy Basin Member of the Morrison Formation that hosts abundant small carbonate concretions. The exhumed and inverted channels closely resemble many seen on the surface of Mars in satellite imagery and which may be visited by surface missions in the near future. The channels contain a wealth of palaeo-environmental information, but intrinsically difficult terrain would make their study challenging on Mars. We show that an unexhumed channel feature can be detected geophysically, this may allow their study in more easily accessed terrain. The concretions morphologically and in their surface expression parallel the haematite blue berries that are strewn across the surface of Meridiani Planum on Mars. They are best developed in poorly cemented medium to coarse channel sandstones and appear to have formed early in the diagenetic history.

LDEF materials special investigation group's data bases

NASA Technical Reports Server (NTRS)

Strickland, John W.; Funk, Joan G.; Davis, John M.

1993-01-01

The Long Duration Exposure Facility (LDEF) was composed of and contained a wide array of materials, representing the largest collection of materials flown for space exposure and returned for ground-based analyses to date. The results and implications of the data from these materials are the foundation on which future space missions will be built. The LDEF Materials Special Investigation Group (MSIG) has been tasked with establishing and developing data bases to document these materials and their performance to assure not only that the data are archived for future generations but also that the data are available to the space user community in an easily accessed, user-friendly form. The format and content of the data bases developed or being developed to accomplish this task are discussed. The hardware and software requirements for each of the three data bases are discussed along with current availability of the data bases.

Effect of Redox “Non-Innocent” Linker on the Catalytic Activity of Copper-Catecholate-Decorated Metal–Organic Frameworks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Xuan; Vermeulen, Nicolaas A.; Huang, Zhiyuan

Two new UiO-68 type of Zr-MOFs featuring redox non-innocent catechol-based linkers of different redox activities have been synthesized through a de novo mixed-linker strategy. Also, metalation of the MOFs with Cu(II) precursors triggers the reduction of Cu(II) by the phenyl-catechol groups to Cu(I) with the concomitant formation of semiquinone radicals as evidenced by EPR and XPS characterization. The MOF-supported catalysts are selective toward the allylic oxidation of cyclohexene and it is found that the presence of in situ-generated Cu(I) species exhibits enhanced catalytic activity as compared to a similar MOF with Cu(II) metalated naphthalenyl-dihydroxy groups. Here, this work unveils themore » importance of metal-support redox interactions in the catalytic activity of MOF-supported catalysts which are not easily accessible in traditional metal oxide supports.« less

NGL Viewer: a web application for molecular visualization.

PubMed

Rose, Alexander S; Hildebrand, Peter W

2015-07-01

The NGL Viewer (http://proteinformatics.charite.de/ngl) is a web application for the visualization of macromolecular structures. By fully adopting capabilities of modern web browsers, such as WebGL, for molecular graphics, the viewer can interactively display large molecular complexes and is also unaffected by the retirement of third-party plug-ins like Flash and Java Applets. Generally, the web application offers comprehensive molecular visualization through a graphical user interface so that life scientists can easily access and profit from available structural data. It supports common structural file-formats (e.g. PDB, mmCIF) and a variety of molecular representations (e.g. 'cartoon, spacefill, licorice'). Moreover, the viewer can be embedded in other web sites to provide specialized visualizations of entries in structural databases or results of structure-related calculations. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

jsNMR: an embedded platform-independent NMR spectrum viewer.

PubMed

Vosegaard, Thomas

2015-04-01

jsNMR is a lightweight NMR spectrum viewer written in JavaScript/HyperText Markup Language (HTML), which provides a cross-platform spectrum visualizer that runs on all computer architectures including mobile devices. Experimental (and simulated) datasets are easily opened in jsNMR by (i) drag and drop on a jsNMR browser window, (ii) by preparing a jsNMR file from the jsNMR web site, or (iii) by mailing the raw data to the jsNMR web portal. jsNMR embeds the original data in the HTML file, so a jsNMR file is a self-transforming dataset that may be exported to various formats, e.g. comma-separated values. The main applications of jsNMR are to provide easy access to NMR data without the need for dedicated software installed and to provide the possibility to visualize NMR spectra on web sites. Copyright © 2015 John Wiley & Sons, Ltd.

A Polyglot Approach to Bioinformatics Data Integration: A Phylogenetic Analysis of HIV-1

PubMed Central

Reisman, Steven; Hatzopoulos, Thomas; Läufer, Konstantin; Thiruvathukal, George K.; Putonti, Catherine

2016-01-01

As sequencing technologies continue to drop in price and increase in throughput, new challenges emerge for the management and accessibility of genomic sequence data. We have developed a pipeline for facilitating the storage, retrieval, and subsequent analysis of molecular data, integrating both sequence and metadata. Taking a polyglot approach involving multiple languages, libraries, and persistence mechanisms, sequence data can be aggregated from publicly available and local repositories. Data are exposed in the form of a RESTful web service, formatted for easy querying, and retrieved for downstream analyses. As a proof of concept, we have developed a resource for annotated HIV-1 sequences. Phylogenetic analyses were conducted for >6,000 HIV-1 sequences revealing spatial and temporal factors influence the evolution of the individual genes uniquely. Nevertheless, signatures of origin can be extrapolated even despite increased globalization. The approach developed here can easily be customized for any species of interest. PMID:26819543

Enantiospecific sp2-sp3 coupling of secondary and tertiary boronic esters

NASA Astrophysics Data System (ADS)

Bonet, Amadeu; Odachowski, Marcin; Leonori, Daniele; Essafi, Stephanie; Aggarwal, Varinder K.

2014-07-01

The cross-coupling of boronic acids and related derivatives with sp2 electrophiles (the Suzuki-Miyaura reaction) is one of the most powerful C-C bond formation reactions in synthesis, with applications that span pharmaceuticals, agrochemicals and high-tech materials. Despite the breadth of its utility, the scope of this Nobel prize-winning reaction is rather limited when applied to aliphatic boronic esters. Primary organoboron reagents work well, but secondary and tertiary boronic esters do not (apart from a few specific and isolated examples). Through an alternative strategy, which does not involve using transition metals, we have discovered that enantioenriched secondary and tertiary boronic esters can be coupled to electron-rich aromatics with essentially complete enantiospecificity. As the enantioenriched boronic esters are easily accessible, this reaction should find considerable application, particularly in the pharmaceutical industry where there is growing awareness of the importance of, and greater clinical success in, creating biomolecules with three-dimensional architectures.

A Framework for Cloudy Model Optimization and Database Storage

NASA Astrophysics Data System (ADS)

Calvén, Emilia; Helton, Andrew; Sankrit, Ravi

2018-01-01

We present a framework for producing Cloudy photoionization models of the nebular emission from novae ejecta and storing a subset of the results in SQL database format for later usage. The database can be searched for models best fitting observed spectral line ratios. Additionally, the framework includes an optimization feature that can be used in tandem with the database to search for and improve on models by creating new Cloudy models while, varying the parameters. The database search and optimization can be used to explore the structures of nebulae by deriving their properties from the best-fit models. The goal is to provide the community with a large database of Cloudy photoionization models, generated from parameters reflecting conditions within novae ejecta, that can be easily fitted to observed spectral lines; either by directly accessing the database using the framework code or by usage of a website specifically made for this purpose.

An Updated Nuclear Equation of State for Neutron Stars and Supernova Simulations

NASA Astrophysics Data System (ADS)

Meixner, M. A.; Mathews, G. J.; Dalhed, H. E.; Lan, N. Q.

2011-10-01

We present an updated and improved Equation of State based upon the framework originally developed by Bowers & Wilson. The details of the EoS and improvements are described along with a description of how to access this EOS for numerical simulations. Among the improvements are an updated compressibility based upon recent measurements, the possibility of the formation of proton excess (Ye> 0.5) material and an improved treatment of the nuclear statistical equilibrium and the transition to pasta nuclei as the density approaches nuclear matter density. The possibility of a QCD chiral phase transition is also included at densities above nuclear matter density. We show comparisons of this EOS with the other two publicly available equations of state used in supernova collapse simulations. The advantages of the present EoS is that it is easily amenable to phenomenological parameterization to fit observed explosion properties and to accommodate new physical parameters.

The braingraph.org database of high resolution structural connectomes and the brain graph tools.

PubMed

Kerepesi, Csaba; Szalkai, Balázs; Varga, Bálint; Grolmusz, Vince

2017-10-01

Based on the data of the NIH-funded Human Connectome Project, we have computed structural connectomes of 426 human subjects in five different resolutions of 83, 129, 234, 463 and 1015 nodes and several edge weights. The graphs are given in anatomically annotated GraphML format that facilitates better further processing and visualization. For 96 subjects, the anatomically classified sub-graphs can also be accessed, formed from the vertices corresponding to distinct lobes or even smaller regions of interests of the brain. For example, one can easily download and study the connectomes, restricted to the frontal lobes or just to the left precuneus of 96 subjects using the data. Partially directed connectomes of 423 subjects are also available for download. We also present a GitHub-deposited set of tools, called the Brain Graph Tools, for several processing tasks of the connectomes on the site http://braingraph.org.

The plan to coordinate NEHRP post-earthquake investigations

USGS Publications Warehouse

Holzer, Thomas L.; Borcherdt, Roger D.; Comartin, Craig D.; Hanson, Robert D.; Scawthorn, Charles R.; Tierney, Kathleen; Youd, T. Leslie

2003-01-01

This is the plan to coordinate domestic and foreign post-earthquake investigations supported by the National Earthquake Hazards Reduction Program (NEHRP). The plan addresses coordination of both the NEHRP agencies—Federal Emergency Management Agency (FEMA), National Institute of Standards and Technology (NIST), National Science Foundation (NSF), and U. S. Geological Survey (USGS)—and their partners. The plan is a framework for both coordinating what is going to be done and identifying responsibilities for post-earthquake investigations. It does not specify what will be done. Coordination is addressed in various time frames ranging from hours to years after an earthquake. The plan includes measures for (1) gaining rapid and general agreement on high-priority research opportunities, and (2) conducting the data gathering and fi eld studies in a coordinated manner. It deals with identifi cation, collection, processing, documentation, archiving, and dissemination of the results of post-earthquake work in a timely manner and easily accessible format.

Standardizing intensive care device data to enable secondary usages.

PubMed

Ingenerf, Josef; Kock, Ann-Kristin; Poelker, Marcel; Seidl, Konrad; Zeplin, Georg; Mersmann, Stefan; Handels, Heinz

2012-01-01

To represent medical device observations in a format that is consumable by clinical software, standards like HL7v3 and ISO/IEEE 11073 should be used jointly. This is demonstrated in a project with Dräger Medical GmbH focusing on their Patient Data Management System (PDMS) in intensive care, called Integrated Care Manager (ICM). Patient and device data of interest should be mapped to suitable formats to enable data exchange and decision support. Instead of mapping device data to target formats bilaterally we use a generic HL7v3 Refined Message Information Model (RMIM) with device specific parts adapted to ISO/IEEE 11073 DIM. The generality of the underlying model (based on Yuksel et al. [1]) allows the flexible inclusion of IEEE 11073 conformant device models of interest on the one hand and the generation of needed artifacts for secondary usages on the other hand, e.g. HL7 V2 messages, HL7 CDA documents like the Personal Health Monitoring Report (PHMR) or web services. Hence, once the medical device data are obtained in the RMIM format, it can quite easily be transformed into HL7-based standard interfaces through XSL transformations because these interfaces all have their building blocks from the same RIM. From there data can be accessed uniformly, e.g. as needed by Dräger´s decision support system SmartCare [2] for automated control and optimization of weaning from mechanical ventilation.

Tools for Integrating Data Access from the IRIS DMC into Research Workflows

NASA Astrophysics Data System (ADS)

Reyes, C. G.; Suleiman, Y. Y.; Trabant, C.; Karstens, R.; Weertman, B. R.

2012-12-01

Web service interfaces at the IRIS Data Management Center (DMC) provide access to a vast archive of seismological and related geophysical data. These interfaces are designed to easily incorporate data access into data processing workflows. Examples of data that may be accessed include: time series data, related metadata, and earthquake information. The DMC has developed command line scripts, MATLAB® interfaces and a Java library to support a wide variety of data access needs. Users of these interfaces do not need to concern themselves with web service details, networking, or even (in most cases) data conversion. Fetch scripts allow access to the DMC archive and are a comfortable fit for command line users. These scripts are written in Perl and are well suited for automation and integration into existing workflows on most operating systems. For metdata and event information, the Fetch scripts even parse the returned data into simple text summaries. The IRIS Java Web Services Library (IRIS-WS Library) allows Java developers the ability to create programs that access the DMC archives seamlessly. By returning the data and information as native Java objects the Library insulates the developer from data formats, network programming and web service details. The MATLAB interfaces leverage this library to allow users access to the DMC archive directly from within MATLAB (r2009b or newer), returning data into variables for immediate use. Data users and research groups are developing other toolkits that use the DMC's web services. Notably, the ObsPy framework developed at LMU Munich is a Python Toolbox that allows seamless access to data and information via the DMC services. Another example is the MATLAB-based GISMO and Waveform Suite developments that can now access data via web services. In summary, there now exist a host of ways that researchers can bring IRIS DMC data directly into their workflows. MATLAB users can use irisFetch.m, command line users can use the various Fetch scripts, Java users can use the IRIS-WS library, and Python users may request data through ObsPy. To learn more about any of these clients see http://www.iris.edu/ws/wsclients/.

Transfer of Solutions to Conditional Probability Problems: Effects of Example Problem Format, Solution Format, and Problem Context

ERIC Educational Resources Information Center

Chow, Alan F.; Van Haneghan, James P.

2016-01-01

This study reports the results of a study examining how easily students are able to transfer frequency solutions to conditional probability problems to novel situations. University students studied either a problem solved using the traditional Bayes formula format or using a natural frequency (tree diagram) format. In addition, the example problem…

Ask an Anatomist: Identifying Global Trends, Topics and Themes of Academic Anatomists Using Twitter

ERIC Educational Resources Information Center

Marsland, Madeleine J.; Lazarus, Michelle D.

2018-01-01

Social media (SoMe) is increasingly used in higher education (HE) to access knowledge and enable global communication. The SoMe platform Twitter® is particularly beneficial in these contexts because it is readily accessible, easily searchable (via hashtags) and global. Given these advantages, the twitter platform @AskAnatomist was created to…

The Effects of Locus of Control on University Students' Mobile Learning Adoption

ERIC Educational Resources Information Center

Hsia, Jung-Wen

2016-01-01

Since mobile devices have become cheaper, easily accessible, powerful, and popular and the cost of wireless access has declined gradually, mobile learning (m-learning) has begun to spread rapidly. To further improve the effectiveness and efficiency of m-learning for university students, it is critical to understand whether they use m-learning.…

Smartphones as Tools for Delivering Sun-Smart Education to Students

ERIC Educational Resources Information Center

Igoe, Damien; Parisi, Alfio; Carter, Brad

2013-01-01

Smartphones are used widely by the general public and students. They are one of the most popular and easily accessible technologies. These devices were originally designed as a means of communication. However, they have evolved into a mobile computing platform with built in sensors and the ability to access a vast number of applications. This…

Integrated visualization of remote sensing data using Google Earth

NASA Astrophysics Data System (ADS)

Castella, M.; Rigo, T.; Argemi, O.; Bech, J.; Pineda, N.; Vilaclara, E.

2009-09-01

The need for advanced visualization tools for meteorological data has lead in the last years to the development of sophisticated software packages either by observing systems manufacturers or by third-party solution providers. For example, manufacturers of remote sensing systems such as weather radars or lightning detection systems include zoom, product selection, archive access capabilities, as well as quantitative tools for data analysis, as standard features which are highly appreciated in weather surveillance or post-event case study analysis. However, the fact that each manufacturer has its own visualization system and data formats hampers the usability and integration of different data sources. In this context, Google Earth (GE) offers the possibility of combining several graphical information types in a unique visualization system which can be easily accessed by users. The Meteorological Service of Catalonia (SMC) has been evaluating the use of GE as a visualization platform for surveillance tasks in adverse weather events. First experiences are related to the integration in real-time of remote sensing data: radar, lightning, and satellite. The tool shows the animation of the combined products in the last hour, giving a good picture of the meteorological situation. One of the main advantages of this product is that is easy to be installed in many computers and does not need high computational requirements. Besides this, the capability of GE provides information about the most affected areas by heavy rain or other weather phenomena. On the opposite, the main disadvantage is that the product offers only qualitative information, and quantitative data is only available though the graphical display (i.e. trough color scales but not associated to physical values that can be accessed by users easily). The procedure developed to run in real time is divided in three parts. First of all, a crontab file launches different applications, depending on the data type (satellite, radar, or lightning) to be treated. For each type of data, the time of launching is different, and goes from 5 (satellite and lightning) to 6 minutes (radar). The second part is the use of IDL and ENVI programs, which search in each archive file the last images in one hour. In the case of lightning data, the files are generated for the procedure, while for the others the procedure searches for existing imagery. Finally, the procedure generates metadata information required by GE, kml files, and sends them to the internal server. At the same time, in the local computer where GE is running, there exists kml files which update the information referring to the server ones. Another application that has been evaluated is the analysis of past events. In this sense, further work is devoted to develop access procedures to archived data via cgi scripts in order to retrieve and convert the information in a format suitable for GE. The presentation includes examples of the evaluation of the use of GE, and a brief comparison with other existing visualization systems available within the SMC.

Gas seal for an in situ oil shale retort and method of forming thermal barrier

DOEpatents

Burton, III, Robert S.

1982-01-01

A gas seal is provided in an access drift excavated in a subterranean formation containing oil shale. The access drift is adjacent an in situ oil shale retort and is in gas communication with the fragmented permeable mass of formation particles containing oil shale formed in the in situ oil shale retort. The mass of formation particles extends into the access drift, forming a rubble pile of formation particles having a face approximately at the angle of repose of fragmented formation. The gas seal includes a temperature barrier which includes a layer of heat insulating material disposed on the face of the rubble pile of formation particles and additionally includes a gas barrier. The gas barrier is a gas-tight bulkhead installed across the access drift at a location in the access drift spaced apart from the temperature barrier.

Globally Gridded Satellite observations for climate studies

USGS Publications Warehouse

Knapp, K.R.; Ansari, S.; Bain, C.L.; Bourassa, M.A.; Dickinson, M.J.; Funk, Chris; Helms, C.N.; Hennon, C.C.; Holmes, C.D.; Huffman, G.J.; Kossin, J.P.; Lee, H.-T.; Loew, A.; Magnusdottir, G.

2011-01-01

Geostationary satellites have provided routine, high temporal resolution Earth observations since the 1970s. Despite the long period of record, use of these data in climate studies has been limited for numerous reasons, among them that no central archive of geostationary data for all international satellites exists, full temporal and spatial resolution data are voluminous, and diverse calibration and navigation formats encumber the uniform processing needed for multisatellite climate studies. The International Satellite Cloud Climatology Project (ISCCP) set the stage for overcoming these issues by archiving a subset of the full-resolution geostationary data at ~10-km resolution at 3-hourly intervals since 1983. Recent efforts at NOAA's National Climatic Data Center to provide convenient access to these data include remapping the data to a standard map projection, recalibrating the data to optimize temporal homogeneity, extending the record of observations back to 1980, and reformatting the data for broad public distribution. The Gridded Satellite (GridSat) dataset includes observations from the visible, infrared window, and infrared water vapor channels. Data are stored in Network Common Data Format (netCDF) using standards that permit a wide variety of tools and libraries to process the data quickly and easily. A novel data layering approach, together with appropriate satellite and file metadata, allows users to access GridSat data at varying levels of complexity based on their needs. The result is a climate data record already in use by the meteorological community. Examples include reanalysis of tropical cyclones, studies of global precipitation, and detection and tracking of the intertropical convergence zone.

Handling the data management needs of high-throughput sequencing data: SpeedGene, a compression algorithm for the efficient storage of genetic data

PubMed Central

2012-01-01

Background As Next-Generation Sequencing data becomes available, existing hardware environments do not provide sufficient storage space and computational power to store and process the data due to their enormous size. This is and will be a frequent problem that is encountered everyday by researchers who are working on genetic data. There are some options available for compressing and storing such data, such as general-purpose compression software, PBAT/PLINK binary format, etc. However, these currently available methods either do not offer sufficient compression rates, or require a great amount of CPU time for decompression and loading every time the data is accessed. Results Here, we propose a novel and simple algorithm for storing such sequencing data. We show that, the compression factor of the algorithm ranges from 16 to several hundreds, which potentially allows SNP data of hundreds of Gigabytes to be stored in hundreds of Megabytes. We provide a C++ implementation of the algorithm, which supports direct loading and parallel loading of the compressed format without requiring extra time for decompression. By applying the algorithm to simulated and real datasets, we show that the algorithm gives greater compression rate than the commonly used compression methods, and the data-loading process takes less time. Also, The C++ library provides direct-data-retrieving functions, which allows the compressed information to be easily accessed by other C++ programs. Conclusions The SpeedGene algorithm enables the storage and the analysis of next generation sequencing data in current hardware environment, making system upgrades unnecessary. PMID:22591016

Globally Gridded Satellite (GridSat) Observations for Climate Studies

NASA Technical Reports Server (NTRS)

Knapp, Kenneth R.; Ansari, Steve; Bain, Caroline L.; Bourassa, Mark A.; Dickinson, Michael J.; Funk, Chris; Helms, Chip N.; Hennon, Christopher C.; Holmes, Christopher D.; Huffman, George J.;

Using CORBA to integrate manufacturing cells to a virtual enterprise

NASA Astrophysics Data System (ADS)

Pancerella, Carmen M.; Whiteside, Robert A.

1997-01-01

It is critical in today's enterprises that manufacturing facilities are not isolated from design, planning, and other business activities and that information flows easily and bidirectionally between these activities. It is also important and cost-effective that COTS software, databases, and corporate legacy codes are well integrated in the information architecture. Further, much of the information generated during manufacturing must be dynamically accessible to engineering and business operations both in a restricted corporate intranet and on the internet. The software integration strategy in the Sandia Agile Manufacturing Testbed supports these enterprise requirements. We are developing a CORBA-based distributed object software system for manufacturing. Each physical machining device is a CORBA object and exports a common IDL interface to allow for rapid and dynamic insertion, deletion, and upgrading within the manufacturing cell. Cell management CORBA components access manufacturing devices without knowledge of any device-specific implementation. To support information flow from design to planning data is accessible to machinists on the shop floor. CORBA allows manufacturing components to be easily accessible to the enterprise. Dynamic clients can be created using web browsers and portable Java GUI's. A CORBA-OLE adapter allows integration to PC desktop applications. Other commercial software can access CORBA network objects in the information architecture through vendor API's.

An Approach to Dynamic Service Management in Pervasive Computing Systems

DTIC Science & Technology

2005-01-01

standard interface to them that is easily accessible by any user. This paper outlines the design of Centaurus , an infrastructure for presenting...based on Extensi- ble Markup Language (XML) for communication, giving the system a uniform and easily adaptable interface. Centaurus defines a...easy and automatic usage. This is the vision that guides our re- search on the Centaurus system. We define a SmartSpace as a dynamic environment that

36 CFR 1193.51 - Compatibility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... BOARD TELECOMMUNICATIONS ACT ACCESSIBILITY GUIDELINES Requirements for Compatibility With Peripheral... user to easily turn any microphone on and off to allow the user to intermix speech with TTY use. (e...

36 CFR 1193.51 - Compatibility.

Code of Federal Regulations, 2011 CFR

2011-07-01

... BOARD TELECOMMUNICATIONS ACT ACCESSIBILITY GUIDELINES Requirements for Compatibility With Peripheral... user to easily turn any microphone on and off to allow the user to intermix speech with TTY use. (e...

Federal Medication Terminologies

Cancer.gov

Federal Medication (FedMed) collaboration of 8 partner agencies agreed on a set of standard, comprehensive, freely and easily accessible FMT terminologies to improve the exchange and public availability of medication information.

Testing the Injectivity of CO2 in a Sub-surface Heterogeneous Reservoir

NASA Astrophysics Data System (ADS)

Sundal, A.; Nystuen, J.; Dypvik, H.; Aagaard, P.

2011-12-01

This case study on subsurface reservoir characterization, considers the effect of geological heterogeneities on the storage capacity and injectivity of the Johansen Formation, which is a deep, saline aquifer underlying the Troll Gas Field off the Norwegian coast. The Johansen Formation has been interpreted as a sandy, prograding unit, deposited in a shallow marine environment during Early Jurassic time, and is overlain by a shaly unit; the Amundsen Formation. It appears as a wedge shaped sandstone body, up to 140m thick, with an areal extent in the order of 10 000 km2. The Johansen Formation is currently being considered for large scale CO2 storage from two gas power plants situated on the west coast of Norway, both of which will operate with full scale CO2 handling, as proposed by Norwegian authorities. The storage capacity needed is in the order of 3 Mt CO2/year. With access to a new 3D seismic survey (Gassnova, 2010), and based on existing well log data from 25 penetrating wells, we have studied large scale geometries and intra-formational features, and built a geo-conceptual model of the Johansen Formation. The reservoir is heterogeneous, with distinct permeability zonation within clinothems separated by less permeable layers. In order to obtain better understanding of crucial reservoir parameters and supplement limited data, comparison of data from easily accessible analogue rock units is useful. For this purpose the unit should be well exposed and thoroughly documented, such as the Panther Tongue Member (Star Point Formation, Mesa Verde Group) in Book Cliffs, from which we have collected some comparable permeability estimates for the model. On a micro scale, mineralogy, grain size/shape and pore geometry constitue major controls on reservoir porosity and permeability. Direct geological information is at this point in time limited to a few meters of core, from which detailed mineralogical information has been derived (optical microscopy, SEM, XRD), and some additional data from side wall cores and cuttings. From this we evaluate facies dependence related to observed diagenetic features and compositional variations due to burial depth (2-4km), mainly considering chlorite coatings (preserving porosity) and cementation (calcite and quartz). Using Schlumberger soft-wares; Petrel (reservoir) and Eclipse (fluid flow), we are testing injection scenarios (one point, several points, bleeding wells) in several intra-formational geological settings. These results will be evaluated relative to the distribution of facies and heterogeneities in the reservoir, considering multiphase flow given the local pressure regime.

"One-Stop Shopping" for Ocean Remote-Sensing and Model Data

NASA Technical Reports Server (NTRS)

Li, P. Peggy; Vu, Quoc; Chao, Yi; Li, Zhi-Jin; Choi, Jei-Kook

2006-01-01

OurOcean Portal 2.0 (http:// ourocean.jpl.nasa.gov) is a software system designed to enable users to easily gain access to ocean observation data, both remote-sensing and in-situ, configure and run an Ocean Model with observation data assimilated on a remote computer, and visualize both the observation data and the model outputs. At present, the observation data and models focus on the California coastal regions and Prince William Sound in Alaska. This system can be used to perform both real-time and retrospective analyses of remote-sensing data and model outputs. OurOcean Portal 2.0 incorporates state-of-the-art information technologies (IT) such as MySQL database, Java Web Server (Apache/Tomcat), Live Access Server (LAS), interactive graphics with Java Applet at the Client site and MatLab/GMT at the server site, and distributed computing. OurOcean currently serves over 20 real-time or historical ocean data products. The data are served in pre-generated plots or their native data format. For some of the datasets, users can choose different plotting parameters and produce customized graphics. OurOcean also serves 3D Ocean Model outputs generated by ROMS (Regional Ocean Model System) using LAS. The Live Access Server (LAS) software, developed by the Pacific Marine Environmental Laboratory (PMEL) of the National Oceanic and Atmospheric Administration (NOAA), is a configurable Web-server program designed to provide flexible access to geo-referenced scientific data. The model output can be views as plots in horizontal slices, depth profiles or time sequences, or can be downloaded as raw data in different data formats, such as NetCDF, ASCII, Binary, etc. The interactive visualization is provided by graphic software, Ferret, also developed by PMEL. In addition, OurOcean allows users with minimal computing resources to configure and run an Ocean Model with data assimilation on a remote computer. Users may select the forcing input, the data to be assimilated, the simulation period, and the output variables and submit the model to run on a backend parallel computer. When the run is complete, the output will be added to the LAS server for

Keemei: cloud-based validation of tabular bioinformatics file formats in Google Sheets.

PubMed

Rideout, Jai Ram; Chase, John H; Bolyen, Evan; Ackermann, Gail; González, Antonio; Knight, Rob; Caporaso, J Gregory

2016-06-13

Bioinformatics software often requires human-generated tabular text files as input and has specific requirements for how those data are formatted. Users frequently manage these data in spreadsheet programs, which is convenient for researchers who are compiling the requisite information because the spreadsheet programs can easily be used on different platforms including laptops and tablets, and because they provide a familiar interface. It is increasingly common for many different researchers to be involved in compiling these data, including study coordinators, clinicians, lab technicians and bioinformaticians. As a result, many research groups are shifting toward using cloud-based spreadsheet programs, such as Google Sheets, which support the concurrent editing of a single spreadsheet by different users working on different platforms. Most of the researchers who enter data are not familiar with the formatting requirements of the bioinformatics programs that will be used, so validating and correcting file formats is often a bottleneck prior to beginning bioinformatics analysis. We present Keemei, a Google Sheets Add-on, for validating tabular files used in bioinformatics analyses. Keemei is available free of charge from Google's Chrome Web Store. Keemei can be installed and run on any web browser supported by Google Sheets. Keemei currently supports the validation of two widely used tabular bioinformatics formats, the Quantitative Insights into Microbial Ecology (QIIME) sample metadata mapping file format and the Spatially Referenced Genetic Data (SRGD) format, but is designed to easily support the addition of others. Keemei will save researchers time and frustration by providing a convenient interface for tabular bioinformatics file format validation. By allowing everyone involved with data entry for a project to easily validate their data, it will reduce the validation and formatting bottlenecks that are commonly encountered when human-generated data files are first used with a bioinformatics system. Simplifying the validation of essential tabular data files, such as sample metadata, will reduce common errors and thereby improve the quality and reliability of research outcomes.

The GBIF Integrated Publishing Toolkit: Facilitating the Efficient Publishing of Biodiversity Data on the Internet

PubMed Central

Robertson, Tim; Döring, Markus; Guralnick, Robert; Bloom, David; Wieczorek, John; Braak, Kyle; Otegui, Javier; Russell, Laura; Desmet, Peter

2014-01-01

The planet is experiencing an ongoing global biodiversity crisis. Measuring the magnitude and rate of change more effectively requires access to organized, easily discoverable, and digitally-formatted biodiversity data, both legacy and new, from across the globe. Assembling this coherent digital representation of biodiversity requires the integration of data that have historically been analog, dispersed, and heterogeneous. The Integrated Publishing Toolkit (IPT) is a software package developed to support biodiversity dataset publication in a common format. The IPT’s two primary functions are to 1) encode existing species occurrence datasets and checklists, such as records from natural history collections or observations, in the Darwin Core standard to enhance interoperability of data, and 2) publish and archive data and metadata for broad use in a Darwin Core Archive, a set of files following a standard format. Here we discuss the key need for the IPT, how it has developed in response to community input, and how it continues to evolve to streamline and enhance the interoperability, discoverability, and mobilization of new data types beyond basic Darwin Core records. We close with a discussion how IPT has impacted the biodiversity research community, how it enhances data publishing in more traditional journal venues, along with new features implemented in the latest version of the IPT, and future plans for more enhancements. PMID:25099149

Enabling Data-as- a-Service (DaaS) - Biggest Challenge of Geoscience Australia

NASA Astrophysics Data System (ADS)

Bastrakova, I.; Kemp, C.; Car, N. J.

2016-12-01

Geoscience Australia (GA) is recognised and respected as the national repository and steward of multiple national significance data collections that provides geoscience information, services and capability to the Australian Government, industry and stakeholders. Provision of Data-as-a-Service is both GA's key responsibility and core business. Through the Science First Transformation Program GA is undergoing a significant rethinking of its data architecture, curation and access to support the Digital Science capability for which DaaS forms both a dependency and underpins its implementation. DaaS, being a service, means we can deliver its outputs in multiple ways thus providing users with data on demand in ready-for-consumption forms. We can then to reuse prebuilt data constructions to allow self-serviced integration of data underpinned by dynamic query tools. In GA's context examples of DaaS are the Australian Geoscience Data Cube, the Foundation Spatial Data Framework and data served through several Virtual Laboratories. We have implemented a three-layered architecture for DaaS in order to store and manage the data while honouring the semantics of Scientific Data Models defined by subject matter experts and GA's Enterprise Data Architecture as well as retain that delivery flexibility. The foundation layer of DaaS is Canonical Datasets, which are optimised for a long-term data stewardship and curation. Data is well structured, standardised, described and audited. All data creation and editing happen within this layer. The middle Data Transformation layer assists with transformation of data from Canonical Datasets to data integration layer. It provides mechanisms for multi-format and multi-technology data transformation. The top Data Integration layer is optimised for data access. Data can be easily reused and repurposed; data formats made available are optimised for scientific computing and adjusted for access by multiple applications, tools and libraries. Moving to DaaS enables GA to increase data alertness, generate new capabilities and be prepared for emerging technological challengers.

GeoMapApp: Using Authentic Geoscience Data to Promote Student Engagement and Understanding

NASA Astrophysics Data System (ADS)

Goodwillie, A. M.

2016-12-01

We increasingly expect geoscience data to be readily and freely accessible via the web in formats that are easy to handle. Yet, we are often required to compile data sets with different formats from multiple sources and, sometimes, we give up in frustration. Fortunately, recent advances in web-enabled technologies are helping to lower barriers by bridging the gap of data accessibility and integration. GeoMapApp (http://www.geomapapp.org), a free data discovery and visualisation tool developed with NSF funding at Lamont-Doherty Earth Observatory provides users with an intuitive map-based interface. GeoMapApp offers free access to hundreds of integrated research-grade geoscience data sets. Examples include earthquake and volcano data, geological maps, lithospheric plate boundary information, geochemical, oceanographic, and environmental data. Users can also import their own data files. The GeoMapApp interface presents data in its proper geographical context that enhances geospatial awareness and helps students more easily gain insight and understanding from the data. Simple tools for data manipulation help students analyse the data in different ways. An improved Save Session function allows users to store a pre-loaded state of GeoMapApp. When shared with a class, the saved file frees up valuable classroom time for students to explore and interrogate the data by allowing every student to open GeoMapApp at exactly the same starting point. GeoMapApp is adaptable to a range of learning environments from lab sessions, group projects, and homework assignments to in-class pop-ups. A wide range of undergraduate enquiry-driven education modules for GeoMapApp is already available at SERC. In this presentation, we will show GeoMapApp-based activities that promote student engagement with authentic geoscience data and that provide a better sense of data "ownership" and of academic equality - GeoMapApp presents the same data in the same tool used by researchers. Topics covered will include plate tectonics and climatology.

Assessing the Unseen: Using Music and Literature to Access and Develop First Graders' Knowledge of Sound Waves

ERIC Educational Resources Information Center

McCourt, Susan; Kelley, Sybil S.

2016-01-01

Most young children love a good song and dance, an enticing story, and gorgeous illustrations. How could this staple of the early childhood classroom--music and literature--access children's ideas about physical science? How can young children communicate their knowledge of unseen science concepts that are not easily represented in pictures? These…

Establishment of the U.S. castor (Ricinus communis L.) core collection using seed chemical composition analysis and genotyping with EST-SSR markers

USDA-ARS?s Scientific Manuscript database

Natural genetic variation exists in the plant germplasm collections. Normally the germplasm collection for a specific species encompasses many accessions. Due to its large number of accessions, the entire collection is hard to handle and can’t be easily utilized. To facilitate the end-users (such as...

Use of the Geographic Information System (GIS) in nurseries

Treesearch

Brent Olson; Chad Loreth

2002-01-01

The use of GIs in nursery operations provides a variety of opportunities. All planning activities can be incorporated into an accessible database. GIS can be used to create ways for employees to access and analyze data. The program can be used for historical record keeping. Use of GIS in planning can improve the efficiency of nursery operations. GIS can easily be used...

Conveying International Space Station Science

NASA Technical Reports Server (NTRS)

Goza, Sharon P.

2017-01-01

Over 1,000 experiments have been completed, and others are being conducted and planed on the International Space Station (ISS). In order to make the information on these experiments accessible, the IGOAL develops mobile applications to easily access this content and video products to convey high level concepts. This presentation will feature the Space Station Research Explorer as well as several publicly available video examples.

Bayesian Inference: with ecological applications

USGS Publications Warehouse

Link, William A.; Barker, Richard J.

2010-01-01

This text provides a mathematically rigorous yet accessible and engaging introduction to Bayesian inference with relevant examples that will be of interest to biologists working in the fields of ecology, wildlife management and environmental studies as well as students in advanced undergraduate statistics.. This text opens the door to Bayesian inference, taking advantage of modern computational efficiencies and easily accessible software to evaluate complex hierarchical models.

GENESI-DR - A single access point to Earth Science data

NASA Astrophysics Data System (ADS)

Cossu, R.; Goncalves, P.; Pacini, F.

2009-04-01

The amount of information being generated about our planet is increasing at an exponential rate, but it must be easily accessible in order to apply it to the global needs relating to the state of the Earth. Currently, information about the state of the Earth, relevant services, analysis results, applications and tools are accessible in a very scattered and uncoordinated way, often through individual initiatives from Earth Observation mission operators, scientific institutes dealing with ground measurements, service companies, data catalogues, etc. A dedicated infrastructure providing transparent access to all this will support Earth Science communities by allowing them to easily and quickly derive objective information and share knowledge based on all environmentally sensitive domains. The use of high-speed networks (GÉANT) and the experimentation of new technologies, like BitTorrent, will also contribute to better services for the Earth Science communities. GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories), an ESA-led, European Commission (EC)-funded two-year project, is taking the lead in providing reliable, easy, long-term access to Earth Science data via the Internet. This project will allow scientists from different Earth Science disciplines located across Europe to locate, access, combine and integrate historical and fresh Earth-related data from space, airborne and in-situ sensors archived in large distributed repositories. GENESI-DR builds a federated collection of heterogeneous digital Earth Science repositories to establish a dedicated infrastructure providing transparent access to all this and allowing Earth Science communities to easily and quickly derive objective information and share knowledge based on all environmentally sensitive domains. The federated digital repositories, seen as services and data providers, will share access to their resources (catalogue functions, data access, processing services etc.) and will adhere to a common set of standards / policies / interfaces. The end-users will be provided with a virtual collection of digital Earth Science data, irrespectively of their location in the various single federated repositories. GENESI-DR objectives have lead to the identification of the basic GENESI-DR infrastructure requirements: • Capability, for Earth Science users, to discover data from different European Earth Science Digital Repositories through the same interface in a transparent and homogeneous way; • Easiness and speed of access to large volumes of coherently maintained distributed data in an effective and timely way; • Capability, for DR owners, to easily make available their data to a significantly increased audience with no need to duplicate them in a different storage system. Data discovery is based on a Central Discovery Service, which allows users and applications to easily query information about data collections and products existing in heterogeneous catalogues, at federated DR sites. This service can be accessed by users via web interface, the GENESI-DR Web Portal, or by external applications via open standardized interfaces exposed by the system. The Central Discovery Service identifies the DRs providing products complying with the user search criteria and returns the corresponding access points to the requester. By taking into consideration different and efficient data transfer technologies such as HTTPS, GridFTP and BitTorrent, the infrastructure provides easiness and speed of access. Conversely, for data publishing GENESI-DR provides several mechanisms to assist DR owners in producing a metadata catalogues. In order to reach its objectives, the GENESI-DR e-Infrastructure will be validated against user needs for accessing and sharing Earth Science data. Initially, four specific applications in the land, atmosphere and marine domains have been selected, including: • Near real time orthorectification for agricultural crops monitoring • Urban area mapping in support of emergency response • Data assimilation in GlobModel, addressing major environmental and health issues in Europe, with a particular focus on air quality • SeaDataNet to aid environmental assessments and to forecast the physical state of the oceans in near real time. Other applications will complement this during the second half of the project. GENESI-DR also aims to develop common approaches to preserve the historical archives and the ability to access the derived user information as both software and hardware transformations occur. Ensuring access to Earth Science data for future generations is of utmost importance because it allows for the continuity of knowledge generation improvement. For instance, scientists accessing today's climate change data in 50 years will be able to better understand and detect trends in global warming and apply this knowledge to ongoing natural phenomena. GENESI-DR will work towards harmonising operations and applying approved standards, policies and interfaces at key Earth Science data repositories. To help with this undertaking, GENESI-DR will establish links with the relevant organisations and programmes such as space agencies, institutional environmental programmes, international Earth Science programmes and standardisation bodies.

Development of an intelligent interface for adding spatial objects to a knowledge-based geographic information system

NASA Technical Reports Server (NTRS)

Campbell, William J.; Goettsche, Craig

1989-01-01

Earth Scientists lack adequate tools for quantifying complex relationships between existing data layers and studying and modeling the dynamic interactions of these data layers. There is a need for an earth systems tool to manipulate multi-layered, heterogeneous data sets that are spatially indexed, such as sensor imagery and maps, easily and intelligently in a single system. The system can access and manipulate data from multiple sensor sources, maps, and from a learned object hierarchy using an advanced knowledge-based geographical information system. A prototype Knowledge-Based Geographic Information System (KBGIS) was recently constructed. Many of the system internals are well developed, but the system lacks an adequate user interface. A methodology is described for developing an intelligent user interface and extending KBGIS to interconnect with existing NASA systems, such as imagery from the Land Analysis System (LAS), atmospheric data in Common Data Format (CDF), and visualization of complex data with the National Space Science Data Center Graphics System. This would allow NASA to quickly explore the utility of such a system, given the ability to transfer data in and out of KBGIS easily. The use and maintenance of the object hierarchies as polymorphic data types brings, to data management, a while new set of problems and issues, few of which have been explored above the prototype level.

OLIVER: an online library of images for veterinary education and research.

PubMed

McGreevy, Paul; Shaw, Tim; Burn, Daniel; Miller, Nick

2007-01-01

As part of a strategic move by the University of Sydney toward increased flexibility in learning, the Faculty of Veterinary Science undertook a number of developments involving Web-based teaching and assessment. OLIVER underpins them by providing a rich, durable repository for learning objects. To integrate Web-based learning, case studies, and didactic presentations for veterinary and animal science students, we established an online library of images and other learning objects for use by academics in the Faculties of Veterinary Science and Agriculture. The objectives of OLIVER were to maximize the use of the faculty's teaching resources by providing a stable archiving facility for graphic images and other multimedia learning objects that allows flexible and precise searching, integrating indexing standards, thesauri, pull-down lists of preferred terms, and linking of objects within cases. OLIVER offers a portable and expandable Web-based shell that facilitates ongoing storage of learning objects in a range of media. Learning objects can be downloaded in common, standardized formats so that they can be easily imported for use in a range of applications, including Microsoft PowerPoint, WebCT, and Microsoft Word. OLIVER now contains more than 9,000 images relating to many facets of veterinary science; these are annotated and supported by search engines that allow rapid access to both images and relevant information. The Web site is easily updated and adapted as required.

Vascular access: a never-ending story.

PubMed

Hedin, U

2014-12-01

Vascular surgeons are more and more becoming responsible for "life-line" creation well functioning and maintenance of hemodialysis patients and to provide a well functioning and multidisciplinary access service together with nefrologists, dialysis staff, and interventional radiology. For many, this sometimes arduous surgery with associated complicated clinical decision making, becomes a constant and challenging burden but much through the appearance of national and international guidelines and especially the endovascular technology, feasible solutions are easily at hand and the life as an access surgeon more pleasant. Here, basics in dialysis access care are presented together with some examples of novel available solutions to troublesome clinical problems.

Across the health-social care divide: elderly people as active users of health care and social care.

PubMed

Roberts, K

2001-03-01

Several ways in which elderly people may assume an active role when using welfare services are discussed here. Selected findings are presented from a study that explored the experience and behaviour of elderly people on discharge from inpatient care with regard to criteria indicating user influence or control (namely participation, representation, access, choice, information and redress). Data were collected via semistructured interviews with service users (n = 30) soon after their return home from hospital. A number of differences were revealed between health care and social care in relation to users being provided with opportunities to assume an active role and in being willing and able to assume an active role. These differences were manifest in elderly service users accessing services, seeking information, exercising choice and acting independently of service providers. It appeared paradoxical that contact points were more easily defined with regard to health care yet users were more likely to exercise choice and act independently in securing social care. It is suggested that social care needs and appropriate service delivery are more easily recognised than making the link between perceived health care needs and appropriate services. In addition, it appeared that informal and private providers are more widely available and accessible for social care. If comprehensive continuing care is to be provided, incorporating both health and social care elements, greater uniformity appears to be required across the welfare sector. Lessons for social care provision from the delivery of health care suggest the clear definition of contact points to facilitate service use. Making health care more accessible, however, does not appear to be easily attainable due to the monopoly provision of health care and the lack of direct purchasing power by potential users.

"TPSX: Thermal Protection System Expert and Material Property Database"

NASA Technical Reports Server (NTRS)

Squire, Thomas H.; Milos, Frank S.; Rasky, Daniel J. (Technical Monitor)

1997-01-01

The Thermal Protection Branch at NASA Ames Research Center has developed a computer program for storing, organizing, and accessing information about thermal protection materials. The program, called Thermal Protection Systems Expert and Material Property Database, or TPSX, is available for the Microsoft Windows operating system. An "on-line" version is also accessible on the World Wide Web. TPSX is designed to be a high-quality source for TPS material properties presented in a convenient, easily accessible form for use by engineers and researchers in the field of high-speed vehicle design. Data can be displayed and printed in several formats. An information window displays a brief description of the material with properties at standard pressure and temperature. A spread sheet window displays complete, detailed property information. Properties which are a function of temperature and/or pressure can be displayed as graphs. In any display the data can be converted from English to SI units with the click of a button. Two material databases included with TPSX are: 1) materials used and/or developed by the Thermal Protection Branch at NASA Ames Research Center, and 2) a database compiled by NASA Johnson Space Center 9JSC). The Ames database contains over 60 advanced TPS materials including flexible blankets, rigid ceramic tiles, and ultra-high temperature ceramics. The JSC database contains over 130 insulative and structural materials. The Ames database is periodically updated and expanded as required to include newly developed materials and material property refinements.

WOVOdat Design Document: The Schema, Table Descriptions, and Create Table Statements for the Database of Worldwide Volcanic Unrest (WOVOdat Version 1.0)

USGS Publications Warehouse

Venezky, Dina Y.; Newhall, Christopher G.

2007-01-01

WOVOdat Overview During periods of volcanic unrest, the ability to forecast near future activity has been a primary concern for human populations living near volcanoes. Our ability to forecast future activity and mitigate hazards is based on knowledge of previous activity at the volcano exhibiting unrest and knowledge of previous activity at similar volcanoes. A small set of experts with past experience are often involved in forecasting. We need to both preserve the knowledge the experts use and continue to investigate volcanic data to make better forecasts. Advances in instrumentation, networking, and data storage technologies have greatly increased our ability to collect volcanic data and share observations with our colleagues. The wealth of data creates numerous opportunities for gaining a better understanding of magmatic conditions and processes, if the data can be easily accessed for comparison. To allow for comparison of volcanic unrest data, we are creating a central database called WOVOdat. WOVOdat will contain a subset of time-series and geo-referenced data from each WOVO observatory in common and easily accessible formats. WOVOdat is being created for volcano experts in charge of forecasting volcanic activity, scientists investigating volcanic processes, and the public. The types of queries each of these groups might ask range from, 'What volcanoes were active in November of 2002?' and 'What are the relationships between tectonic earthquakes and volcanic processes?' to complex analyses of volcanic unrest to determine what future activity might occur. A new structure for storing and accessing our data was needed to examine processes across a wide range of volcanologic conditions. WOVOdat provides this new structure using relationships to connect the data parameters such that searches can be created for analogs of unrest. The subset of data that will fill WOVOdat will continue to be collected by the observatories, who will remain the primary archives of raw and detailed data on individual episodes of unrest. MySQL, an Open Source database, was chosen as the WOVOdat database for its integration with common web languages. The question of where the data will be stored and how the disparate data sets will be integrated will not be discussed in detail here. The focus of this document is to explain the data types, formats, and table organization chosen for WOVOdat 1.0. It was written for database administrators, data loaders, query writers, and anyone who monitors volcanoes. We begin with an overview of several challenges faced and solutions used in creating the WOVOdat schema. Specifics are then given for the parameters and table organization. After each table organization section, basic create table statements are included for viewing the database field formats. In the next stage of the project, scripts will be needed for data conversion, entry, and cleansing. Views will also need to be created once the data have been loaded and the basic queries are better known. Many questions and opportunities remain. We look forward to the growth and continual improvement in efficiency of the system. We hope WOVOdat will improve our understanding of magmatic systems and help mitigate future volcanic hazards.

Accessing Suomi NPP OMPS Products through the GES DISC Online Data Services

NASA Technical Reports Server (NTRS)

Johnson, J.; Wei, J.; Gerasimov, I.; Vollmer, Bruce E.

2017-01-01

This presentation will provide an overview of the OMPS products available at the GES DISC archive, as well as demonstrate the various data services provided by the GES DISC. Since the TOMS, SBUV, and EOS Aura (OMI, MLS, HIRDLS) data products are also available from the GES DISC archive, these can be easily accessed and compared with the OMPS data.

D-Tagatose inhibits the growth and biofilm formation of Streptococcus mutans

PubMed Central

Hasibul, Khaleque; Nakayama-Imaohji, Haruyuki; Hashimoto, Masahito; Yamasaki, Hisashi; Ogawa, Takaaki; Waki, Junpei; Tada, Ayano; Yoneda, Saori; Tokuda, Masaaki; Miyake, Minoru; Kuwahara, Tomomi

2018-01-01

Dental caries is an important global health concern and Streptococcus mutans has been established as a major cariogenic bacterial species. Reports indicate that a rare sugar, D-tagatose, is not easily catabolized by pathogenic bacteria. In the present study, the inhibitory effects of D-tagatose on the growth and biofilm formation of S. mutans GS-5 were examined. Monitoring S. mutans growth over a 24 h period revealed that D-tagatose prolonged the lag phase without interfering with the final cell yield. This growth retardation was also observed in the presence of 1% sucrose, although it was abolished by the addition of D-fructose. S. mutans biofilm formation was significantly inhibited by growth in sucrose media supplemented with 1 and 4% D-tagatose compared with that in a culture containing sucrose alone, while S. mutans formed granular biofilms in the presence of this rare sugar. The inhibitory effect of D-tagatose on S. mutans biofilm formation was significantly more evident than that of xylitol. Growth in sucrose media supplemented with D-tagatose significantly decreased the expression of glucosyltransferase, exo-β-fructosidase and D-fructose-specific phosphotransferase genes but not the expression of fructosyltransferase compared with the culture containing sucrose only. The activity of cell-associated glucosyltransferase in S. mutans was inhibited by 4% D-tagatose. These results indicate that D-tagatose reduces water-insoluble glucan production from sucrose by inhibiting glucosyltransferase activities, which limits access to the free D-fructose released during this process and retards the growth of S. mutans. Therefore, foods and oral care products containing D-tagatose are anticipated to reduce the risk of caries by inhibiting S. mutans biofilm formation. PMID:29115611

Field Audit Checklist Tool (FACT)

EPA Pesticide Factsheets

Download EPA's The Field Audit Checklist Tool (FACT). FACT is intended to help auditors perform field audits, to easily view monitoring plan, quality assurance and emissions data and provides access to data collected under MATS.

39 CFR 7.6 - Certification and transcripts of closed meetings.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Corporate Communications Department at Postal Service Headquarters, or in another place easily accessible to... of this electronic recording disclosing the identity of each speaker, to any person at the actual...

39 CFR 7.6 - Certification and transcripts of closed meetings.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Corporate Communications Department at Postal Service Headquarters, or in another place easily accessible to... of this electronic recording disclosing the identity of each speaker, to any person at the actual...

39 CFR 7.6 - Certification and transcripts of closed meetings.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Corporate Communications Department at Postal Service Headquarters, or in another place easily accessible to... of this electronic recording disclosing the identity of each speaker, to any person at the actual...

39 CFR 7.6 - Certification and transcripts of closed meetings.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Corporate Communications Department at Postal Service Headquarters, or in another place easily accessible to... of this electronic recording disclosing the identity of each speaker, to any person at the actual...

39 CFR 7.6 - Certification and transcripts of closed meetings.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Corporate Communications Department at Postal Service Headquarters, or in another place easily accessible to... of this electronic recording disclosing the identity of each speaker, to any person at the actual...

Find a Support Group (Brain Tumor)

MedlinePlus

... seek support. Located in the heart of Union Square and easily accessible by the 4,5,6, ... subway lines. Meeting location: Mount Sinai Downtown Union Square, 10 Union Square East, 5th floor, Conference Room ...

ENVIRONMENTAL INFORMATION MANAGEMENT SYSTEM (EIMS)

EPA Science Inventory

The Environmental Information Management System (EIMS) organizes descriptive information (metadata) for data sets, databases, documents, models, projects, and spatial data. The EIMS design provides a repository for scientific documentation that can be easily accessed with standar...

Going "open" with mesoscopy: a new dimension on multi-view imaging.

PubMed

Gualda, Emilio; Moreno, Nuno; Tomancak, Pavel; Martins, Gabriel G

2014-03-01

OpenSPIM and OpenSpinMicroscopy emerged as open access platforms for Light Sheet and Optical Projection Imaging, often called as optical mesoscopy techniques. Both projects can be easily reproduced using comprehensive online instructions that should foster the implementation and further development of optical imaging techniques with sample rotation control. This additional dimension in an open system offers the possibility to make multi-view microscopy easily modified and will complement the emerging commercial solutions. Furthermore, it is deeply based on other open platforms such as MicroManager and Arduino, enabling development of tailored setups for very specific biological questions. In our perspective, the open access principle of OpenSPIM and OpenSpinMicroscopy is a game-changer, helping the concepts of light sheet and optical projection tomography (OPT) to enter the mainstream of biological imaging.

What Can OpenEI Do For You?

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2010-12-10

Open Energy Information (OpenEI) is an open source web platform—similar to the one used by Wikipedia—developed by the US Department of Energy (DOE) and the National Renewable Energy Laboratory (NREL) to make the large amounts of energy-related data and information more easily searched, accessed, and used both by people and automated machine processes. Built utilizing the standards and practices of the Linked Open Data community, the OpenEI platform is much more robust and powerful than typical web sites and databases. As an open platform, all users can search, edit, add, and access data in OpenEI for free. The user communitymore » contributes the content and ensures its accuracy and relevance; as the community expands, so does the content's comprehensiveness and quality. The data are structured and tagged with descriptors to enable cross-linking among related data sets, advanced search functionality, and consistent, usable formatting. Data input protocols and quality standards help ensure the content is structured and described properly and derived from a credible source. Although DOE/NREL is developing OpenEI and seeding it with initial data, it is designed to become a true community model with millions of users, a large core of active contributors, and numerous sponsors.« less

FocusStack and StimServer: a new open source MATLAB toolchain for visual stimulation and analysis of two-photon calcium neuronal imaging data.

PubMed

Muir, Dylan R; Kampa, Björn M

2014-01-01

Two-photon calcium imaging of neuronal responses is an increasingly accessible technology for probing population responses in cortex at single cell resolution, and with reasonable and improving temporal resolution. However, analysis of two-photon data is usually performed using ad-hoc solutions. To date, no publicly available software exists for straightforward analysis of stimulus-triggered two-photon imaging experiments. In addition, the increasing data rates of two-photon acquisition systems imply increasing cost of computing hardware required for in-memory analysis. Here we present a Matlab toolbox, FocusStack, for simple and efficient analysis of two-photon calcium imaging stacks on consumer-level hardware, with minimal memory footprint. We also present a Matlab toolbox, StimServer, for generation and sequencing of visual stimuli, designed to be triggered over a network link from a two-photon acquisition system. FocusStack is compatible out of the box with several existing two-photon acquisition systems, and is simple to adapt to arbitrary binary file formats. Analysis tools such as stack alignment for movement correction, automated cell detection and peri-stimulus time histograms are already provided, and further tools can be easily incorporated. Both packages are available as publicly-accessible source-code repositories.

FocusStack and StimServer: a new open source MATLAB toolchain for visual stimulation and analysis of two-photon calcium neuronal imaging data

PubMed Central

Muir, Dylan R.; Kampa, Björn M.

2015-01-01

Two-photon calcium imaging of neuronal responses is an increasingly accessible technology for probing population responses in cortex at single cell resolution, and with reasonable and improving temporal resolution. However, analysis of two-photon data is usually performed using ad-hoc solutions. To date, no publicly available software exists for straightforward analysis of stimulus-triggered two-photon imaging experiments. In addition, the increasing data rates of two-photon acquisition systems imply increasing cost of computing hardware required for in-memory analysis. Here we present a Matlab toolbox, FocusStack, for simple and efficient analysis of two-photon calcium imaging stacks on consumer-level hardware, with minimal memory footprint. We also present a Matlab toolbox, StimServer, for generation and sequencing of visual stimuli, designed to be triggered over a network link from a two-photon acquisition system. FocusStack is compatible out of the box with several existing two-photon acquisition systems, and is simple to adapt to arbitrary binary file formats. Analysis tools such as stack alignment for movement correction, automated cell detection and peri-stimulus time histograms are already provided, and further tools can be easily incorporated. Both packages are available as publicly-accessible source-code repositories1. PMID:25653614

What Can OpenEI Do For You?

ScienceCinema

None

2018-02-06

Open Energy Information (OpenEI) is an open source web platform—similar to the one used by Wikipedia—developed by the US Department of Energy (DOE) and the National Renewable Energy Laboratory (NREL) to make the large amounts of energy-related data and information more easily searched, accessed, and used both by people and automated machine processes. Built utilizing the standards and practices of the Linked Open Data community, the OpenEI platform is much more robust and powerful than typical web sites and databases. As an open platform, all users can search, edit, add, and access data in OpenEI for free. The user community contributes the content and ensures its accuracy and relevance; as the community expands, so does the content's comprehensiveness and quality. The data are structured and tagged with descriptors to enable cross-linking among related data sets, advanced search functionality, and consistent, usable formatting. Data input protocols and quality standards help ensure the content is structured and described properly and derived from a credible source. Although DOE/NREL is developing OpenEI and seeding it with initial data, it is designed to become a true community model with millions of users, a large core of active contributors, and numerous sponsors.

Application of XML in DICOM

NASA Astrophysics Data System (ADS)

You, Xiaozhen; Yao, Zhihong

2005-04-01

As a standard of communication and storage for medical digital images, DICOM has been playing a very important role in integration of hospital information. In DICOM, tags are expressed by numbers, and only standard data elements can be shared by looking up Data Dictionary while private tags can not. As such, a DICOM file's readability and extensibility is limited. In addition, reading DICOM files needs special software. In our research, we introduced XML into DICOM, defining an XML-based DICOM special transfer format, XML-DCM, a DICOM storage format, X-DCM, as well as developing a program package to realize format interchange among DICOM, XML-DCM, and X-DCM. XML-DCM is based on the DICOM structure while replacing numeric tags with accessible XML character string tags. The merits are as following: a) every character string tag of XML-DCM has explicit meaning, so users can understand standard data elements and those private data elements easily without looking up the Data Dictionary. In this way, the readability and data sharing of DICOM files are greatly improved; b) According to requirements, users can set new character string tags with explicit meaning to their own system to extend the capacity of data elements; c) User can read the medical image and associated information conveniently through IE, ultimately enlarging the scope of data sharing. The application of storage format X-DCM will reduce data redundancy and save storage memory. The result of practical application shows that XML-DCM does favor integration and share of medical image data among different systems or devices.

MDWiZ: a platform for the automated translation of molecular dynamics simulations.

PubMed

Rusu, Victor H; Horta, Vitor A C; Horta, Bruno A C; Lins, Roberto D; Baron, Riccardo

2014-03-01

A variety of popular molecular dynamics (MD) simulation packages were independently developed in the last decades to reach diverse scientific goals. However, such non-coordinated development of software, force fields, and analysis tools for molecular simulations gave rise to an array of software formats and arbitrary conventions for routine preparation and analysis of simulation input and output data. Different formats and/or parameter definitions are used at each stage of the modeling process despite largely contain redundant information between alternative software tools. Such Babel of languages that cannot be easily and univocally translated one into another poses one of the major technical obstacles to the preparation, translation, and comparison of molecular simulation data that users face on a daily basis. Here, we present the MDWiZ platform, a freely accessed online portal designed to aid the fast and reliable preparation and conversion of file formats that allows researchers to reproduce or generate data from MD simulations using different setups, including force fields and models with different underlying potential forms. The general structure of MDWiZ is presented, the features of version 1.0 are detailed, and an extensive validation based on GROMACS to LAMMPS conversion is presented. We believe that MDWiZ will be largely useful to the molecular dynamics community. Such fast format and force field exchange for a given system allows tailoring the chosen system to a given computer platform and/or taking advantage of a specific capabilities offered by different software engines. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

Best Practices for Preparing Interoperable Geospatial Data

NASA Astrophysics Data System (ADS)

Wei, Y.; Santhana Vannan, S.; Cook, R. B.; Wilson, B. E.; Beaty, T. W.

2010-12-01

Geospatial data is critically important for a wide scope of research and applications: carbon cycle and ecosystem, climate change, land use and urban planning, environmental protecting, etc. Geospatial data is created by different organizations using different methods, from remote sensing observations, field surveys, model simulations, etc., and stored in various formats. So geospatial data is diverse and heterogeneous, which brings a huge barrier for the sharing and using of geospatial data, especially when targeting a broad user community. Many efforts have been taken to address different aspects of using geospatial data by improving its interoperability. For example, the specification for Open Geospatial Consortium (OGC) catalog services defines a standard way for geospatial information discovery; OGC Web Coverage Services (WCS) and OPeNDAP define interoperable protocols for geospatial data access, respectively. But the reality is that only having the standard mechanisms for data discovery and access is not enough. The geospatial data content itself has to be organized in standard, easily understandable, and readily usable formats. The Oak Ridge National Lab Distributed Archived Data Center (ORNL DAAC) archives data and information relevant to biogeochemical dynamics, ecological data, and environmental processes. The Modeling and Synthesis Thematic Data Center (MAST-DC) prepares and distributes both input data and output data of carbon cycle models and provides data support for synthesis and terrestrial model inter-comparison in multi-scales. Both of these NASA-funded data centers compile and distribute a large amount of diverse geospatial data and have broad user communities, including GIS users, Earth science researchers, and ecosystem modeling teams. The ORNL DAAC and MAST-DC address this geospatial data interoperability issue by standardizing the data content and feeding them into a well-designed Spatial Data Infrastructure (SDI) which provides interoperable mechanisms to advertise, visualize, and distribute the standardized geospatial data. In this presentation, we summarize the experiences learned and the best practices for geospatial data standardization. The presentation will describe how diverse and historical data archived in the ORNL DAAC were converted into standard and non-proprietary formats; what tools were used to make the conversion; how the spatial and temporal information are properly captured in a consistent manor; how to name a data file or a variable to make it both human-friendly and semantically interoperable; how NetCDF file format and CF convention can promote the data usage in ecosystem modeling user community; how those standardized geospatial data can be fed into OGC Web Services to support on-demand data visualization and access; and how the metadata should be collected and organized so that they can be discovered through standard catalog services.

47 CFR 79.109 - Activating accessibility features.

Code of Federal Regulations, 2014 CFR

2014-10-01

... ACCESSIBILITY OF VIDEO PROGRAMMING Apparatus § 79.109 Activating accessibility features. (a) Requirements... video programming transmitted in digital format simultaneously with sound, including apparatus designed to receive or display video programming transmitted in digital format using Internet protocol, with...

Transferable Output ASCII Data (TOAD) gateway: Version 1.0 user's guide

NASA Technical Reports Server (NTRS)

Bingel, Bradford D.

1991-01-01

The Transferable Output ASCII Data (TOAD) Gateway, release 1.0 is described. This is a software tool for converting tabular data from one format into another via the TOAD format. This initial release of the Gateway allows free data interchange among the following file formats: TOAD; Standard Interface File (SIF); Program to Optimize Simulated Trajectories (POST) input; Comma Separated Value (TSV); and a general free-form file format. As required, additional formats can be accommodated quickly and easily.

Astronomy: On the Bleeding Edge of Scholarly Infrastructure

NASA Astrophysics Data System (ADS)

Borgman, Christine; Sands, A.; Wynholds, L. A.

2013-01-01

The infrastructure for scholarship has moved online, making data, articles, papers, journals, catalogs, and other scholarly resources nodes in a deeply interconnected network. Astronomy has led the way on several fronts, developing tools such as ADS to provide unified access to astronomical publications and reaching agreement on a common data file formats such as FITS. Astronomy also was among the first fields to establish open access to substantial amounts of observational data. We report on the first three years of a long-term research project to study knowledge infrastructures in astronomy, funded by the NSF and the Alfred P. Sloan Foundation. Early findings indicate that the availability and use of networked technologies for integrating scholarly resources varies widely within astronomy. Substantial differences arise in the management of data between ground-based and space-based missions and between subfields of astronomy, for example. While large databases such as SDSS and MAST are essential resources for many researchers, much pointed, ground-based observational data exist only on local servers, with minimal curation. Some astronomy data are easily discoverable and usable, but many are not. International coordination activities such as IVOA and distributed access to high-level data products servers such as SIMBAD and NED are enabling further integration of published data. Astronomers are tackling yet more challenges in new forms of publishing data, algorithms, visualizations, and in assuring interoperability with parallel infrastructure efforts in related fields. New issues include data citation, attribution, and provenance. Substantial concerns remain for the long term discoverability, accessibility, usability, and curation of astronomy data and other scholarly resources. The presentation will outline these challenges, how they are being addressed by astronomy and related fields, and identify concerns and accomplishments expressed by the astronomers we have interviewed and observed.

Improving User Access to the Integrated Multi-Satellite Retrievals for GPM (IMERG) Products

NASA Astrophysics Data System (ADS)

Huffman, George; Bolvin, David; Nelkin, Eric; Kidd, Christopher

2016-04-01

The U.S. Global Precipitation Measurement mission (GPM) team has developed the Integrated Multi-satellitE Retrievals for GPM (IMERG) algorithm to take advantage of the international constellation of precipitation-relevant satellites and the Global Precipitation Climatology Centre surface precipitation gauge analysis. The goal is to provide a long record of homogeneous, high-resolution quasi-global estimates of precipitation. While expert scientific researchers are major users of the IMERG products, it is clear that many other user communities and disciplines also desire access to the data for wide-ranging applications. Lessons learned during the Tropical Rainfall Measuring Mission, the predecessor to GPM, led to some basic design choices that provided the framework for supporting multiple user bases. For example, two near-real-time "runs" are computed, the Early and Late (currently 5 and 15 hours after observation time, respectively), then the Final Run about 3 months later. The datasets contain multiple fields that provide insight into the computation of the complete precipitation data field, as well as diagnostic (currently) estimates of the precipitation's phase. In parallel with this, the archive sites are working to provide the IMERG data in a variety of formats, and with subsetting and simple interactive analysis to make the data more easily available to non-expert users. The various options for accessing the data are summarized under the pmm.nasa.gov data access page. The talk will end by considering the feasibility of major user requests, including polar coverage, a simplified Data Quality Index, and reduced data latency for the Early Run. In brief, the first two are challenging, but under the team's control. The last requires significant action by some of the satellite data providers.

Utah Flooding Hazard: Raising Public Awareness through the Creation of Multidisciplinary Web-Based Maps

NASA Astrophysics Data System (ADS)

Castleton, J.; Erickson, B.; Bowman, S. D.; Unger, C. D.

2014-12-01

The Utah Geological Survey's (UGS) Geologic Hazards Program has partnered with the U.S. Army Corps of Engineers to create geologically derived web-based flood hazard maps. Flooding in Utah communities has historically been one of the most damaging geologic hazards. The most serious floods in Utah have generally occurred in the Great Salt Lake basin, particularly in the Weber River drainage on the western slopes of the Wasatch Range, in areas of high population density. With a growing population of 2.9 million, the state of Utah is motivated to raise awareness about the potential for flooding. The process of increasing community resiliency to flooding begins with identification and characterization of flood hazards. Many small communities in areas experiencing rapid growth have not been mapped completely by the Federal Emergency Management Agency (FEMA) Flood Insurance Rate Maps (FIRM). Existing FIRM maps typically only consider drainage areas that are greater than one square mile in determining flood zones and do not incorporate geologic data, such as the presence of young, geologically active alluvial fans that indicate a high potential for debris flows and sheet flooding. Our new flood hazard mapping combines and expands on FEMA data by incorporating mapping derived from 1:24,000-scale UGS geologic maps, LiDAR data, digital elevation models, and historical aerial photography. Our flood hazard maps are intended to supplement the FIRM maps to provide local governments and the public with additional flood hazard information so they may make informed decisions, ultimately reducing the risk to life and property from flooding hazards. Flooding information must be widely available and easily accessed. One of the most effective ways to inform the public is through web-based maps. Web-based flood hazard maps will not only supply the public with the flood information they need, but also provides a platform to add additional geologic hazards to an easily accessible format.

Lessons Learned from a Decade of Serving Data to Students and the Public

NASA Astrophysics Data System (ADS)

Chambers, L. H.; Martin, A. M.; Riebeek, H.; Jackson, R.

2015-12-01

NASA holds petabytes of Earth science data from a fleet of satellites going back decades. While these data can be invaluable for use in STEM education and communication (E/C), the simple fact that the archive is public is not enough. The key to successful use is to provide technological tools in strategic combination with best practices to meet the needs of various audiences. Students and teachers need access points that are specifically tailored to meet the technology resources in the classroom; citizen scientists need to feel a connection to NASA, easy-to-use technological interfaces, and are motivated by contributing to real research activities; the general public needs short, focused, easily digested tidbits. NASA's Earth science E/C teams have developed strategies combining audience knowledge with new technical capabilities through programs like MY NASA DATA, S'COOL, Earth Observatory, Giovanni, climate.gov, etc. The capability to offer a range of resources targeted to specific audience needs has advanced along several fronts over the last decade through use of the following key strategies: Regularly publishing articles, fact sheets and image captions written with greater detail than media releases to connect basic science concepts with current NASA research. Providing for differing levels of engagement, with basic, intermediate and advanced data access tools as well as lesson plans for grades K-2 through high school. Facilitating the important scientific process of asking questions once students are actively engaged though exploration and manipulation of current Earth data delivered through desktop and mobile apps.. Providing curated data sets that students can more easily interpret. Assessing users' needs through ongoing formative evaluation. Using Analytics to make data-driven decisions about technologies and approaches. We will survey the range of approaches to enabling data use for STEM E/C and will share some of the key lessons learned.

The GOLM-database standard- a framework for time-series data management based on free software

NASA Astrophysics Data System (ADS)

Eichler, M.; Francke, T.; Kneis, D.; Reusser, D.

2009-04-01

Monitoring and modelling projects usually involve time series data originating from different sources. Often, file formats, temporal resolution and meta-data documentation rarely adhere to a common standard. As a result, much effort is spent on converting, harmonizing, merging, checking, resampling and reformatting these data. Moreover, in work groups or during the course of time, these tasks tend to be carried out redundantly and repeatedly, especially when new data becomes available. The resulting duplication of data in various formats strains additional ressources. We propose a database structure and complementary scripts for facilitating these tasks. The GOLM- (General Observation and Location Management) framework allows for import and storage of time series data of different type while assisting in meta-data documentation, plausibility checking and harmonization. The imported data can be visually inspected and its coverage among locations and variables may be visualized. Supplementing scripts provide options for data export for selected stations and variables and resampling of the data to the desired temporal resolution. These tools can, for example, be used for generating model input files or reports. Since GOLM fully supports network access, the system can be used efficiently by distributed working groups accessing the same data over the internet. GOLM's database structure and the complementary scripts can easily be customized to specific needs. Any involved software such as MySQL, R, PHP, OpenOffice as well as the scripts for building and using the data base, including documentation, are free for download. GOLM was developed out of the practical requirements of the OPAQUE-project. It has been tested and further refined in the ERANET-CRUE and SESAM projects, all of which used GOLM to manage meteorological, hydrological and/or water quality data.

Restoration of Apollo Data for Future Lunar Exploration

NASA Astrophysics Data System (ADS)

Schultz, Alfred B.; Williams, D. R.; Hills, H. K.

2007-10-01

The Lunar Data Project (LDP) at NASA's National Space Science Data Center (NSSDC) is retrieving and restoring relevant, scientifically important Apollo data into accessible digital form for use by researchers and mission planners. Much of the Apollo data housed at the NSSDC are in forms which are not readily usable, such as microfilm, hardcopy, and magnetic tapes written using machine representations of computers no longer in use. The LDP has prioritized these data based on scientific and engineering value and level of effort required and is in the process of restoring these data collections. In association with the Planetary Data System (PDS), the restored data are converted into standard format and subject to a data peer review before ingestion into PDS. The Apollo 12 and 15 Solar Wind Spectrometer data have been restored and are awaiting data review. The Apollo 14 and 15 ALSEP Cold Cathode Ion Gage data have been scanned, the Apollo 14 Dust, Thermal, and Radiation Engineering Measurements data are in the process of being scanned, and the Apollo 14 Charged Particle Lunar Environment Experiment data have been retrieved from magnetic tape. An optical character recognition software to produce digital tables of the scanned data, where appropriate, is under development. These data represent some of the only long-term lunar surface environment information that exists. We will report on our progress. Metadata, ancillary information to aid in the use and understanding of the data, will be included in these online data collections. These cover complete descriptions of the data sets, formats, processing history, relevant references and contacts, and instrument descriptions. Restored data and associated metadata are posted online and easily accessible to interested users. The data sets and more information on the LDP can be found at nssdc.gsfc.nasa.gov/planetary/lunar/lunar_data/

Human- and computer-accessible 2D correlation data for a more reliable structure determination of organic compounds. Future roles of researchers, software developers, spectrometer managers, journal editors, reviewers, publisher and database managers toward artificial-intelligence analysis of NMR spectra.

PubMed

Jeannerat, Damien

2017-01-01

The introduction of a universal data format to report the correlation data of 2D NMR spectra such as COSY, HSQC and HMBC spectra will have a large impact on the reliability of structure determination of small organic molecules. These lists of assigned cross peaks will bridge signals found in NMR 1D and 2D spectra and the assigned chemical structure. The record could be very compact, human and computer readable so that it can be included in the supplementary material of publications and easily transferred into databases of scientific literature and chemical compounds. The records will allow authors, reviewers and future users to test the consistency and, in favorable situations, the uniqueness of the assignment of the correlation data to the associated chemical structures. Ideally, the data format of the correlation data should include direct links to the NMR spectra to make it possible to validate their reliability and allow direct comparison of spectra. In order to take the full benefits of their potential, the correlation data and the NMR spectra should therefore follow any manuscript in the review process and be stored in open-access database after publication. Keeping all NMR spectra, correlation data and assigned structures together at all time will allow the future development of validation tools increasing the reliability of past and future NMR data. This will facilitate the development of artificial intelligence analysis of NMR spectra by providing a source of data than can be used efficiently because they have been validated or can be validated by future users. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

OLYMPUS DISS - A Readily Implemented Geographic Data and Information Sharing System

NASA Astrophysics Data System (ADS)

Necsoiu, D. M.; Winfrey, B.; Murphy, K.; McKague, H. L.

2002-12-01

Electronic information technology has become a crucial component of business, government, and scientific organizations. In this technology era, many enterprises are moving away from the perception that information repositories are only a tool for decision-making. Instead, many organizations are learning that information systems, which are capable of organizing and following the interrelations between information and both the short-term and strategic organizational goals, are assets themselves, with inherent value. Olympus Data and Information Sharing System (DISS) is a system developed at the Center for Nuclear Waste Regulatory Analyses (CNWRA) to solve several difficult tasks associated with the management of geographical, geological and geophysical data. Three of the tasks were to (1) gather the large amount of heterogeneous information that has accumulated over the operational lifespan of CNWRA, (2) store the data in a central, knowledge-based, searchable database and (3) create quick, easy, convenient, and reliable access to that information. Faced with these difficult tasks CNWRA identified the requirements for designing such a system. Key design criteria were: (a) ability to ingest different data formats (i.e., raster, vector, and tabular data); (b) minimal expense using open-source and commercial off-the-shelf software; (c) seamless management of geospatial data, freeing up time for researchers to focus on analyses or algorithm development, rather than on time consuming format conversions; (d) controlled access; and (e) scalable architecture to meet new and continuing demands. Olympus DISS is a solution that can be easily adapted to small and mid-size enterprises dealing with heterogeneous geographic data. It uses established data standards, provides a flexible mechanism to build applications upon and output geographic data in multiple and clear ways. This abstract is an independent product of the CNWRA and does not necessarily reflect the views or regulatory position of the Nuclear Regulatory Commission.

Improving Access to Transit Through Crowdsourced Information

DOT National Transportation Integrated Search

2017-11-01

The purpose of this research was to facilitate the ongoing collection of information from the public about potential areas of multimodal service and infrastructure improvements and easily share these problems with transit agencies, departments of tra...

India: Gujarat

Atmospheric Science Data Center

2013-04-16

... Gujarat), and in areas close to the earthquake epicenter.  Research uses the unique capabilities of the Multi-angle Imaging ... Indo-Pakistani border, which were not easily accessible to survey teams on the ground. Changes in reflection at different view angles ...

WILLIAMSBURG BROOKLYN ASTHMA AND ENVIRONMENT CONSORTIUM

EPA Science Inventory

The Consortium expects to develop a family health promotion model in which organized residents have access to easily understood, scientifically accurate, community-specific information about their health, their environment, and the relationship between the two,...

Real-Time Data Filtering and Compression in Wide Area Simulation Networks

DTIC Science & Technology

1992-10-02

Area Simulation Networks Achieving the real-time linkage among multiple , geographically-distant, local area networks that support distributed...November 1989, pp. 52-61. [IEEE85] IEEE/ANSI Standard 8802/3 "Carrier sense multiple access with collision detection (CSMA/CD) access method and...decoding/encoding of multiple bits. The hardware is programmable, easily adaptable and yields a high compression rate. A prototype 2-micron VLSI chip

Netmeld v. 1.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

BERG, MICHAEL; RILEY, MARSHALL

System assessments typically yield large quantities of data from disparate sources for an analyst to scrutinize for issues. Netmeld is used to parse input from different file formats, store the data in a common format, allow users to easily query it, and enable analysts to tie different analysis tools together using a common back-end.

Extra dimensions: 3d and time in pdf documentation

NASA Astrophysics Data System (ADS)

Graf, N. A.

2008-07-01

High energy physics is replete with multi-dimensional information which is often poorly represented by the two dimensions of presentation slides and print media. Past efforts to disseminate such information to a wider audience have failed for a number of reasons, including a lack of standards which are easy to implement and have broad support. Adobe's Portable Document Format (PDF) has in recent years become the de facto standard for secure, dependable electronic information exchange. It has done so by creating an open format, providing support for multiple platforms and being reliable and extensible. By providing support for the ECMA standard Universal 3D (U3D) file format in its free Adobe Reader software, Adobe has made it easy to distribute and interact with 3D content. By providing support for scripting and animation, temporal data can also be easily distributed to a wide audience. In this talk, we present examples of HEP applications which take advantage of this functionality. We demonstrate how 3D detector elements can be documented, using either CAD drawings or other sources such as GEANT visualizations as input. Using this technique, higher dimensional data, such as LEGO plots or time-dependent information can be included in PDF files. In principle, a complete event display, with full interactivity, can be incorporated into a PDF file. This would allow the end user not only to customize the view and representation of the data, but to access the underlying data itself.

Seismo-Live: Training in Seismology with Jupyter Notebooks

NASA Astrophysics Data System (ADS)

Krischer, Lion; Tape, Carl; Igel, Heiner

2016-04-01

Seismological training tends to occur within the isolation of a particular institution with a limited set of tools (codes, libraries) that are often not transferrable outside. Here, we propose to overcome these limitations with a community-driven library of Jupyter notebooks dedicated to training on any aspect of seismology for purposes of education and outreach, on-site or archived tutorials for codes, classroom instruction, and research. A Jupyter notebook (jupyter.org) is an open-source interactive computational environment that allows combining code execution, rich text, mathematics, and plotting. It can be considered a platform that supports reproducible research, as all inputs and outputs may be stored. Text, external graphics, equations can be handled using Markdown (incl. LaTeX) format. Jupyter notebooks are driven by standard web browsers, can be easily exchanged in text format, or converted to other documents (e.g. PDF, slide shows). They provide an ideal format for practical training in seismology. A pilot-platform was setup with a dedicated server such that the Jupyter notebooks can be run in any browser (PC, notepad, smartphone). We show the functionalities of the Seismo-Live platform with examples from computational seismology, seismic data access and processing using the ObsPy library, seismic inverse problems, and others. The current examples are all using the Python programming language but any free language can be used. Potentially, such community platforms could be integrated with the EPOS-IT infrastructure and extended to other fields of Earth sciences.

Extra Dimensions: 3D and Time in PDF Documentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Graf, Norman A.; /SLAC

2011-11-10

High energy physics is replete with multi-dimensional information which is often poorly represented by the two dimensions of presentation slides and print media. Past efforts to disseminate such information to a wider audience have failed for a number of reasons, including a lack of standards which are easy to implement and have broad support. Adobe's Portable Document Format (PDF) has in recent years become the de facto standard for secure, dependable electronic information exchange. It has done so by creating an open format, providing support for multiple platforms and being reliable and extensible. By providing support for the ECMA standardmore » Universal 3D (U3D) file format in its free Adobe Reader software, Adobe has made it easy to distribute and interact with 3D content. By providing support for scripting and animation, temporal data can also be easily distributed to a wide audience. In this talk, we present examples of HEP applications which take advantage of this functionality. We demonstrate how 3D detector elements can be documented, using either CAD drawings or other sources such as GEANT visualizations as input. Using this technique, higher dimensional data, such as LEGO plots or time-dependent information can be included in PDF files. In principle, a complete event display, with full interactivity, can be incorporated into a PDF file. This would allow the end user not only to customize the view and representation of the data, but to access the underlying data itself.« less

The Galaxy Cluster Merger Catalog: An Online Repository of Mock Observations from Simulated Galaxy Cluster Mergers

NASA Astrophysics Data System (ADS)

ZuHone, J. A.; Kowalik, K.; Öhman, E.; Lau, E.; Nagai, D.

2018-01-01

We present the “Galaxy Cluster Merger Catalog.” This catalog provides an extensive suite of mock observations and related data for N-body and hydrodynamical simulations of galaxy cluster mergers and clusters from cosmological simulations. These mock observations consist of projections of a number of important observable quantities in several different wavebands, as well as along different lines of sight through each simulation domain. The web interface to the catalog consists of easily browsable images over epoch and projection direction, as well as download links for the raw data and a JS9 interface for interactive data exploration. The data are presented within a consistent format so that comparison between simulations is straightforward. All of the data products are provided in the standard Flexible Image Transport System file format. The data are being stored on the yt Hub (http://hub.yt), which allows for remote access and analysis using a Jupyter notebook server. Future versions of the catalog will include simulations from a number of research groups and a variety of research topics related to the study of interactions of galaxy clusters with each other and with their member galaxies. The catalog is located at http://gcmc.hub.yt.

Aerodynamic levitation, supercooled liquids and glass formation

DOE PAGES

Benmore, C. J.; Weber, J. K. R.

2017-05-04

Containerless processing or ‘levitation’ is a valuable tool for the synthesis and characterization of materials, particularly at extreme temperatures and under non-equilibrium conditions. The method enables formation of novel glasses, amorphous phases, and metastable crystalline forms that are not easily accessed when nucleation and growth can readily occur at a container interface. Removing the container enables the use of a wide variety of process atmospheres to modify a materials structure and properties. In the past decade levitation methods, including acoustic, aerodynamic, electromagnetic, and electrostatic, have become well established sample environments at X-ray synchrotron and neutron sources. This article briefly reviewsmore » the methods and then focuses on the application of aerodynamic levitation to synthesize and study new materials. This is presented in conjunction with non-contact probes used to investigate the atomic structure and to measure the properties of materials at extreme temperatures. The use of aerodynamic levitation in research using small and wide-angle X-ray diffraction, XANES, and neutron scattering are discussed in the context of technique development. The use of the containerless methods to investigate thermophysical properties is also considered. We argue that structural motifs and in the liquid state can potentially lead to the fabrication of materials, whose properties would differ substantially from their well known crystalline forms.« less

Visualization of High-Resolution LiDAR Topography in Google Earth

NASA Astrophysics Data System (ADS)

Crosby, C. J.; Nandigam, V.; Arrowsmith, R.; Blair, J. L.

2009-12-01

The growing availability of high-resolution LiDAR (Light Detection And Ranging) topographic data has proven to be revolutionary for Earth science research. These data allow scientists to study the processes acting on the Earth’s surfaces at resolutions not previously possible yet essential for their appropriate representation. In addition to their utility for research, the data have also been recognized as powerful tools for communicating earth science concepts for education and outreach purposes. Unfortunately, the massive volume of data produced by LiDAR mapping technology can be a barrier to their use. To facilitate access to these powerful data for research and educational purposes, we have been exploring the use of Keyhole Markup Language (KML) and Google Earth to deliver LiDAR-derived visualizations. The OpenTopography Portal (http://www.opentopography.org/) is a National Science Foundation-funded facility designed to provide access to Earth science-oriented LiDAR data. OpenTopography hosts a growing collection of LiDAR data for a variety of geologic domains, including many of the active faults in the western United States. We have found that the wide spectrum of LiDAR users have variable scientific applications, computing resources, and technical experience and thus require a data distribution system that provides various levels of access to the data. For users seeking a synoptic view of the data, and for education and outreach purposes, delivering full-resolution images derived from LiDAR topography into the Google Earth virtual globe is powerful. The virtual globe environment provides a freely available and easily navigated viewer and enables quick integration of the LiDAR visualizations with imagery, geographic layers, and other relevant data available in KML format. Through region-dependant network linked KML, OpenTopography currently delivers over 20 GB of LiDAR-derived imagery to users via simple, easily downloaded KMZ files hosted at the Portal. This method provides seamlessly access to hillshaded imagery for both bare earth and first return terrain models with various angles of illumination. Seamless access to LiDAR-derived imagery in Google Earth has proven to be the most popular product available in the OpenTopography Portal. The hillshade KMZ files have been downloaded over 3000 times by users ranging from earthquake scientists to K-12 educators who wish to introduce cutting edge real world data into their earth science lessons. OpenTopography also provides dynamically generated KMZ visualizations of LiDAR data products produced when users choose to use the OpenTopography point cloud access and processing system. These Google Earth compatible products allow users to quickly visualize the custom terrain products they have generated without the burden of loading the data into a GIS environment. For users who have installed the Google Earth browser plug-in, these visualizations can be launched directly from the OpenTopography results page and viewed directly in the browser.

77 FR 71460 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-30

... notice for a period of at least two years in an easily accessible place. This rule addresses the problem... of $27,750 (3,700 notices multiplied by $7.50 per notice). The Commission may not conduct or sponsor...

Action Planning for Prevention and Recovery: A Self-Help Guide

MedlinePlus

... everything, from really easily accessible things, like taking deep breaths, to things you only do once in ... self-help books that help you relax through deep breathing and focusing your attention on cer- tain ...

Facial attractiveness impressions precede trustworthiness inferences: lower detection thresholds and faster decision latencies.

PubMed

Gutiérrez-García, Aida; Beltrán, David; Calvo, Manuel G

2018-02-26

Prior research has found a relationship between perceived facial attractiveness and perceived personal trustworthiness. We examined the time course of attractiveness relative to trustworthiness evaluation of emotional and neutral faces. This served to explore whether attractiveness might be used as an easily accessible cue and a quick shortcut for judging trustworthiness. Detection thresholds and judgment latencies as a function of expressive intensity were measured. Significant correlations between attractiveness and trustworthiness consistently held for six emotional expressions at four intensities, and neutral faces. Importantly, perceived attractiveness preceded perceived trustworthiness, with lower detection thresholds and shorter decision latencies. This reveals a time course advantage for attractiveness, and suggests that earlier attractiveness impressions could bias trustworthiness inferences. A heuristic cognitive mechanism is hypothesised to ease processing demands by relying on simple and observable clues (attractiveness) as a substitute for more complex and not easily accessible information (trustworthiness).

The INDIGO-Datacloud Authentication and Authorization Infrastructure

NASA Astrophysics Data System (ADS)

Ceccanti, A.; Hardt, M.; Wegh, B.; Millar, AP; Caberletti, M.; Vianello, E.; Licehammer, S.

2017-10-01

Contemporary distributed computing infrastructures (DCIs) are not easily and securely accessible by scientists. These computing environments are typically hard to integrate due to interoperability problems resulting from the use of different authentication mechanisms, identity negotiation protocols and access control policies. Such limitations have a big impact on the user experience making it hard for user communities to port and run their scientific applications on resources aggregated from multiple providers. The INDIGO-DataCloud project wants to provide the services and tools needed to enable a secure composition of resources from multiple providers in support of scientific applications. In order to do so, a common AAI architecture has to be defined that supports multiple authentication mechanisms, support delegated authorization across services and can be easily integrated in off-the-shelf software. In this contribution we introduce the INDIGO Authentication and Authorization Infrastructure, describing its main components and their status and how authentication, delegation and authorization flows are implemented across services.

3,4-Dihydro-2H-pyrrole-2-carbonitriles: Useful Intermediates in the Synthesis of Fused Pyrroles and 2,2'-Bipyrroles.

PubMed

Nebe, Marco M; Kucukdisli, Murat; Opatz, Till

2016-05-20

Various heterocyclic structures containing the pyrrole moiety have been synthesized from easily accessible 3,4-dihydro-2H-pyrrole-2-carbonitriles in one-pot procedures. 5,6,7,8-Tetrahydroindolizines, 2,3-dihydro-1H-pyrrolizines as well as 6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]azepines were obtained from these precursors in high yields in an alkylation/annulation sequence. The same conditions were applied in the synthesis of a 5,8-dihydroindolizine, which could easily be transformed to the corresponding indolizine by dehydrogenation. Furthermore, oxidative couplings of 3,4-dihydro-2H-pyrrole-2-carbonitriles with copper(II)-salts furnished 2,2'-bipyrroles as well as 5,5'-bis(5-cyano-1-pyrrolines), depending on the reaction conditions. Overall, these methods give high yielding access to a variety of pyrrole-containing heterocyles in two steps from commercially available starting materials.

Generalized Nanosatellite Avionics Testbed Lab

NASA Technical Reports Server (NTRS)

Frost, Chad R.; Sorgenfrei, Matthew C.; Nehrenz, Matt

2015-01-01

The Generalized Nanosatellite Avionics Testbed (G-NAT) lab at NASA Ames Research Center provides a flexible, easily accessible platform for developing hardware and software for advanced small spacecraft. A collaboration between the Mission Design Division and the Intelligent Systems Division, the objective of the lab is to provide testing data and general test protocols for advanced sensors, actuators, and processors for CubeSat-class spacecraft. By developing test schemes for advanced components outside of the standard mission lifecycle, the lab is able to help reduce the risk carried by advanced nanosatellite or CubeSat missions. Such missions are often allocated very little time for testing, and too often the test facilities must be custom-built for the needs of the mission at hand. The G-NAT lab helps to eliminate these problems by providing an existing suite of testbeds that combines easily accessible, commercial-offthe- shelf (COTS) processors with a collection of existing sensors and actuators.

SU-F-J-100: Standardized Biodistribution Template for Nuclear Medicine Dosimetry Collection and Reporting

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kesner, A; Poli, G; Beykan, S

Purpose: As the field of Nuclear Medicine moves forward with efforts to integrate radiation dosimetry into clinical practice we can identify the challenge posed by the lack of standardized dose calculation methods and protocols. All personalized internal dosimetry is derived by projecting biodistribution measurements into dosimetry calculations. In an effort to standardize organization of data and its reporting, we have developed, as a sequel to the EANM recommendation of “Good Dosimetry Reporting”, a freely available biodistribution template, which can be used to create a common point of reference for dosimetry data. It can be disseminated, interpreted, and used for methodmore » development widely across the field. Methods: A generalized biodistribution template was built in a comma delineated format (.csv) to be completed by users performing biodistribution measurements. The template is available for free download. The download site includes instructions and other usage details on the template. Results: This is a new resource developed for the community. It is our hope that users will consider integrating it into their dosimetry operations. Having biodistribution data available and easily accessible for all patients processed is a strategy for organizing large amounts of information. It may enable users to create their own databases that can be analyzed for multiple aspects of dosimetry operations. Furthermore, it enables population data to easily be reprocessed using different dosimetry methodologies. With respect to dosimetry-related research and publications, the biodistribution template can be included as supplementary material, and will allow others in the community to better compare calculations and results achieved. Conclusion: As dosimetry in nuclear medicine become more routinely applied in clinical applications, we, as a field, need to develop the infrastructure for handling large amounts of data. Our organ level biodistribution template can be used as a standard format for data collection, organization, as well as for dosimetry research and software development.« less

Using action research to design bereavement software: engaging people with intellectual disabilities for effective development.

PubMed

Read, Sue; Nte, Sol; Corcoran, Patsy; Stephens, Richard

2013-05-01

 Loss is a universal experience and death is perceived as the ultimate loss. The overarching aim of this research is to produce a qualitative, flexible, interactive, computerised tool to support the facilitation of emotional expressions around loss for people with intellectual disabilities. This paper explores the process of using Participatory Action Research (PAR) to develop this tool.  Participator Action Research provided the indicative framework for the process of developing a software tool that is likely to be used in practice. People with intellectual disability worked alongside researchers to produce an accessible, flexible piece of software that can facilitate storytelling around loss and bereavement and promote spontaneous expression that can be shared with others. This tool has the capacity to enable individuals to capture experiences in a storyboard format; that can be stored; is easily retrievable; can be printed out; and could feasibly be personalised by the insertion of photographs. © 2012 Blackwell Publishing Ltd.

LDEF materials data bases

NASA Technical Reports Server (NTRS)

Funk, Joan G.; Strickland, John W.; Davis, John M.

1993-01-01

The Long Duration Exposure Facility (LDEF) and the accompanying experiments were composed of and contained a wide variety of materials representing the largest collection of materials flown in low Earth orbit (LEO) and retrieved for ground based analysis to date. The results and implications of the mechanical, thermal, optical, and electrical data from these materials are the foundation on which future LEO space missions will be built. The LDEF Materials Special Investigation Group (MSIG) has been charged with establishing and developing data bases to document these materials and their performance to assure not only that the data are archived for future generations but also that the data are available to the spacecraft user community in an easily accessed, user-friendly form. This paper discusses the format and content of the three data bases developed or being developed to accomplish this task. The hardware and software requirements for each of these three data bases are discussed along with current availability of the data bases. This paper also serves as a user's guide to the MAPTIS LDEF Materials Data Base.

Towards Designing an Integrated Earth Observation System for the Provision of Solar Energy Resource and Assessment

NASA Technical Reports Server (NTRS)

Stackouse, Paul W., Jr.; Renne, D.; Beyer, H.-G.; Wald, L.; Meyers, R.; Perez, R.; Suri, M.

2006-01-01

The GEOSS strategic plan specifically targets the area of improved energy resource management due to the importance of these to the economic and social viability of every nation of the world. With the world s increasing demand for energy resources, the need for new alternative energy resources grows. This paper overviews a new initiative within the International Energy Agency that addresses needs to better manage and develop solar energy resources worldwide. The goal is to provide the solar energy industry, the electricity sector, governments, and renewable energy organizations and institutions with the most suitable and accurate information of the solar radiation resources at the Earth's surface in easily-accessible formats and understandable quality metrics. The scope of solar resource assessment information includes historic data sets and currently derived data products using satellite imagery and other means. Thus, this new task will address the needs of the solar energy sector while at the same time will serve as a model that satisfies GEOSS objectives and goals.

Electronic Engineering Notebook: A software environment for research execution, documentation and dissemination

NASA Technical Reports Server (NTRS)

Moerder, Dan

1994-01-01

The electronic engineering notebook (EEN) consists of a free form research notebook, implemented in a commercial package for distributed hypermedia, which includes utilities for graphics capture, formatting and display of LaTex constructs, and interfaces to the host operating system. The latter capability consists of an information computer-aided software engineering (CASE) tool and a means to associate executable scripts with source objects. The EEN runs on Sun and HP workstations. The EEN, in day-to-day use can be used in much the same manner as the sort of research notes most researchers keep during development of projects. Graphics can be pasted in, equations can be entered via LaTex, etc. In addition, the fact that the EEN is hypermedia permits easy management of 'context', e.g., derivations and data can contain easily formed links to other supporting derivations and data. The CASE tool also permits development and maintenance of source code directly in the notebook, with access to its derivations and data.

GenomeHubs: simple containerized setup of a custom Ensembl database and web server for any species

PubMed Central

Kumar, Sujai; Stevens, Lewis; Blaxter, Mark

2017-01-01

Abstract As the generation and use of genomic datasets is becoming increasingly common in all areas of biology, the need for resources to collate, analyse and present data from one or more genome projects is becoming more pressing. The Ensembl platform is a powerful tool to make genome data and cross-species analyses easily accessible through a web interface and a comprehensive application programming interface. Here we introduce GenomeHubs, which provide a containerized environment to facilitate the setup and hosting of custom Ensembl genome browsers. This simplifies mirroring of existing content and import of new genomic data into the Ensembl database schema. GenomeHubs also provide a set of analysis containers to decorate imported genomes with results of standard analyses and functional annotations and support export to flat files, including EMBL format for submission of assemblies and annotations to International Nucleotide Sequence Database Collaboration. Database URL: http://GenomeHubs.org PMID:28605774

HED-TIE: A wafer-scale approach for fabricating hybrid electronic devices with trench isolated electrodes

NASA Astrophysics Data System (ADS)

Banerjee, Sreetama; Bülz, Daniel; Solonenko, Dmytro; Reuter, Danny; Deibel, Carsten; Hiller, Karla; Zahn, Dietrich R. T.; Salvan, Georgeta

2017-05-01

Organic-inorganic hybrid electronic devices (HEDs) offer opportunities for functionalities that are not easily obtainable with either organic or inorganic materials individually. In the strive for down-scaling the channel length in planar geometry HEDs, the best results were achieved with electron beam lithography or nanoimprint lithography. Their application on the wafer level is, however, cost intensive and time consuming. Here, we propose trench isolated electrode (TIE) technology as a fast, cost effective, wafer-level approach for the fabrication of planar HEDs with electrode gaps in the range of 100 nm. We demonstrate that the formation of the organic channel can be realized by deposition from solution as well as by the thermal evaporation of organic molecules. To underline one key feature of planar HED-TIEs, namely full accessibility of the active area of the devices by external stimuli such as light, 6,13-bis (triisopropylsilylethynyl) (TIPS)-pentacene/Au HED-TIEs are successfully tested for possible application as hybrid photodetectors in the visible spectral range.

Synthesis of E- and Z-trisubstituted alkenes by catalytic cross-metathesis

NASA Astrophysics Data System (ADS)

Nguyen, Thach T.; Koh, Ming Joo; Mann, Tyler J.; Schrock, Richard R.; Hoveyda, Amir H.

2017-12-01

Catalytic cross-metathesis is a central transformation in chemistry, yet corresponding methods for the stereoselective generation of acyclic trisubstituted alkenes in either the E or the Z isomeric forms are not known. The key problems are a lack of chemoselectivity—namely, the preponderance of side reactions involving only the less hindered starting alkene, resulting in homo-metathesis by-products—and the formation of short-lived methylidene complexes. By contrast, in catalytic cross-coupling, substrates are more distinct and homocoupling is less of a problem. Here we show that through cross-metathesis reactions involving E- or Z-trisubstituted alkenes, which are easily prepared from commercially available starting materials by cross-coupling reactions, many desirable and otherwise difficult-to-access linear E- or Z-trisubstituted alkenes can be synthesized efficiently and in exceptional stereoisomeric purity (up to 98 per cent E or 95 per cent Z). The utility of the strategy is demonstrated by the concise stereoselective syntheses of biologically active compounds, such as the antifungal indiacen B and the anti-inflammatory coibacin D.

Synthesis of E- and Z-trisubstituted alkenes by catalytic cross-metathesis.

PubMed

Nguyen, Thach T; Koh, Ming Joo; Mann, Tyler J; Schrock, Richard R; Hoveyda, Amir H

2017-12-20

Catalytic cross-metathesis is a central transformation in chemistry, yet corresponding methods for the stereoselective generation of acyclic trisubstituted alkenes in either the E or the Z isomeric forms are not known. The key problems are a lack of chemoselectivity-namely, the preponderance of side reactions involving only the less hindered starting alkene, resulting in homo-metathesis by-products-and the formation of short-lived methylidene complexes. By contrast, in catalytic cross-coupling, substrates are more distinct and homocoupling is less of a problem. Here we show that through cross-metathesis reactions involving E- or Z-trisubstituted alkenes, which are easily prepared from commercially available starting materials by cross-coupling reactions, many desirable and otherwise difficult-to-access linear E- or Z-trisubstituted alkenes can be synthesized efficiently and in exceptional stereoisomeric purity (up to 98 per cent E or 95 per cent Z). The utility of the strategy is demonstrated by the concise stereoselective syntheses of biologically active compounds, such as the antifungal indiacen B and the anti-inflammatory coibacin D.

A New Generation of Crystallographic Validation Tools for the Protein Data Bank

PubMed Central

Read, Randy J.; Adams, Paul D.; Arendall, W. Bryan; Brunger, Axel T.; Emsley, Paul; Joosten, Robbie P.; Kleywegt, Gerard J.; Krissinel, Eugene B.; Lütteke, Thomas; Otwinowski, Zbyszek; Perrakis, Anastassis; Richardson, Jane S.; Sheffler, William H.; Smith, Janet L.; Tickle, Ian J.; Vriend, Gert; Zwart, Peter H.

2011-01-01

Summary This report presents the conclusions of the X-ray Validation Task Force of the worldwide Protein Data Bank (PDB). The PDB has expanded massively since current criteria for validation of deposited structures were adopted, allowing a much more sophisticated understanding of all the components of macromolecular crystals. The size of the PDB creates new opportunities to validate structures by comparison with the existing database, and the now-mandatory deposition of structure factors creates new opportunities to validate the underlying diffraction data. These developments highlighted the need for a new assessment of validation criteria. The Task Force recommends that a small set of validation data be presented in an easily understood format, relative to both the full PDB and the applicable resolution class, with greater detail available to interested users. Most importantly, we recommend that referees and editors judging the quality of structural experiments have access to a concise summary of well-established quality indicators. PMID:22000512

Footprint Database and web services for the Herschel space observatory

NASA Astrophysics Data System (ADS)

Verebélyi, Erika; Dobos, László; Kiss, Csaba

2015-08-01

Using all telemetry and observational meta-data, we created a searchable database of Herschel observation footprints. Data from the Herschel space observatory is freely available for everyone but no uniformly processed catalog of all observations has been published yet. As a first step, we unified the data model for all three Herschel instruments in all observation modes and compiled a database of sky coverage information. As opposed to methods using a pixellation of the sphere, in our database, sky coverage is stored in exact geometric form allowing for precise area calculations. Indexing of the footprints allows for very fast search among observations based on pointing, time, sky coverage overlap and meta-data. This enables us, for example, to find moving objects easily in Herschel fields. The database is accessible via a web site and also as a set of REST web service functions which makes it usable from program clients like Python or IDL scripts. Data is available in various formats including Virtual Observatory standards.

Improving the security of international ISO container traffic by centralizing the archival of inspection results

NASA Astrophysics Data System (ADS)

Chalmers, Alex

2004-09-01

To increase the security and throughput of ISO traffic through international terminals more technology must be applied to the problem. A transnational central archive of inspection records is discussed that can be accessed by national agencies as ISO containers approach their borders. The intent is to improve the throughput and security of the cargo inspection process. A review of currently available digital media archiving technologies is presented and their possible application to the tracking of international ISO container shipments. Specific image formats employed by current x-ray inspection systems are discussed. Sample x-ray data from systems in use today are shown that could be entered into such a system. Data from other inspection technologies are shown to be easily integrated, as well as the creation of database records suitable for interfacing with other computer systems. Overall system performance requirements are discussed in terms of security, response time and capacity. Suggestions for pilot projects based on existing border inspection processes are made also.

A new generation of crystallographic validation tools for the protein data bank.

PubMed

Read, Randy J; Adams, Paul D; Arendall, W Bryan; Brunger, Axel T; Emsley, Paul; Joosten, Robbie P; Kleywegt, Gerard J; Krissinel, Eugene B; Lütteke, Thomas; Otwinowski, Zbyszek; Perrakis, Anastassis; Richardson, Jane S; Sheffler, William H; Smith, Janet L; Tickle, Ian J; Vriend, Gert; Zwart, Peter H

2011-10-12

This report presents the conclusions of the X-ray Validation Task Force of the worldwide Protein Data Bank (PDB). The PDB has expanded massively since current criteria for validation of deposited structures were adopted, allowing a much more sophisticated understanding of all the components of macromolecular crystals. The size of the PDB creates new opportunities to validate structures by comparison with the existing database, and the now-mandatory deposition of structure factors creates new opportunities to validate the underlying diffraction data. These developments highlighted the need for a new assessment of validation criteria. The Task Force recommends that a small set of validation data be presented in an easily understood format, relative to both the full PDB and the applicable resolution class, with greater detail available to interested users. Most importantly, we recommend that referees and editors judging the quality of structural experiments have access to a concise summary of well-established quality indicators. Copyright © 2011 Elsevier Ltd. All rights reserved.

The flood control controversy: Big dams, little dams, and land management

USGS Publications Warehouse

Leopold, Luna Bergere; Maddock, Thomas

1954-01-01

The purpose of this book is to investigate the facts regarding flood control, a subject that has given rise to extreme controversy in the United States in recent years. The question of flood control is obviously a vital one not only to the United States but to many other countries. It is hoped that this book may lead to a far clearer understanding of the facts involved and so may prove a truly important influence in reconciling existing differences of opinion.Most of the material presented here has not previously been available to the general reader nor has it been easily accessible to professional people. Much of it, in fact, has been gathered by the authors from unpublished reports of government agencies and from discussions with technicians in the field. Part of the material, on the other hand, such as the sections on flood plain formation and the hydrologic effect of small dams, stems from original research by the authors.

Imaging, Health Record, and Artificial Intelligence: Hype or Hope?

PubMed

Mazzanti, Marco; Shirka, Ervina; Gjergo, Hortensia; Hasimi, Endri

2018-05-10

The review is focused on "digital health", which means advanced analytics based on multi-modal data. The "Health Care Internet of Things", which uses sensors, apps, and remote monitoring could provide continuous clinical information in the cloud that enables clinicians to access the information they need to care for patients everywhere. Greater standardization of acquisition protocols will be needed to maximize the potential gains from automation and machine learning. Recent artificial intelligence applications on cardiac imaging will not be diagnosing patients and replacing doctors but will be augmenting their ability to find key relevant data they need to care for a patient and present it in a concise, easily digestible format. Risk stratification will transition from oversimplified population-based risk scores to machine learning-based metrics incorporating a large number of patient-specific clinical and imaging variables in real-time beyond the limits of human cognition. This will deliver highly accurate and individual personalized risk assessments and facilitate tailored management plans.

Addressing Open Water Data Challenges in the Bureau of Reclamation

NASA Astrophysics Data System (ADS)

Brekke, L. D.; Danner, A.; Nagode, J.; Rocha, J.; Poulton, S.; Anderson, A.

2017-12-01

The Bureau of Reclamation is largest wholesaler of water in the United States. Located in the 17 western states, Reclamation serves water to 31 million people, provides irrigated water to 20 percent of Western farmers, and is the second largest producer of hydroelectric power in the United States. Through these activities, Reclamation generates large amounts of water and water-related data, describing reservoirs and river system conditions, hydropower, environmental compliance activities, infrastructure assets, and other aspects of Reclamation's mission activities. Reclamation aims to make water and water-related data sets more easily found, accessed, and used in decision-making activities in order to benefit the public, private sector, and research communities. Historically, there has not been an integrated, bureau-wide system to store data in machine-readable formats; nor a system to permit centralized browsing, open access, and web-services. Reclamation began addressing these limitations by developing the Reclamation Water Information System (RWIS), released in Spring 2017 (https://water.usbr.gov/). A bureau-wide team contributed to RWIS development, including water data stewards, database administrators, and information technology (IT) specialists. The first RWIS release publishes reservoir time series data from Reclamation's five regions and includes a map interface for sites identification, a query interface for data discovery and access, and web-services for automated retrieval. As RWIS enhancement continues, the development team is developing a companion system - the Reclamation Information Sharing Environment (RISE) - to provide access to the other data subjects and types (geospatial, documents). While RWIS and RISE are promising starts, Reclamation continues to face challenges in addressing open water data goals: making data consolidation and open publishing a value-added activity for programs that publish data locally, going beyond providing open access to also providing decision-support, and scaling up IT solutions for future success - where Reclamation programs increasingly elect to more and more data through RWIS/RISE, thereby creating a big data challenge. This presentation will highlight activities status, lessons learned, and future directions.

Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors.

PubMed

Angeli, A; Peat, T S; Bartolucci, G; Nocentini, A; Supuran, C T; Carta, F

2016-12-28

A mild, efficient and one pot procedure to access benzoxazoles using easily accessible acylselenoureas as starting materials has been discovered. Mechanistic studies revealed a pH dependent intramolecular oxidative deselenization, with ring closure due to an intramolecular nucleophilic attack of a phenoxide ion. All the benzoxazoles herein reported possessed a primary sulfonamide zinc binding group and showed effective inhibitory action on the enzymes, carbonic anhydrases.

Ratio measures in leading medical journals: structured review of accessibility of underlying absolute risks

PubMed Central

Schwartz, Lisa M; Dvorin, Evan L; Welch, H Gilbert

2006-01-01

Objective To examine the accessibility of absolute risk in articles reporting ratio measures in leading medical journals. Design Structured review of abstracts presenting ratio measures. Setting Articles published between 1 June 2003 and 1 May 2004 in Annals of Internal Medicine, BMJ, Journal of the American Medical Association, Journal of the National Cancer Institute, Lancet, and New England Journal of Medicine. Participants 222 articles based on study designs in which absolute risks were directly calculable (61 randomised trials, 161 cohort studies). Main outcome measure Accessibility of the absolute risks underlying the first ratio measure in the abstract. Results 68% of articles (150/222) failed to report the underlying absolute risks for the first ratio measure in the abstract (range 55−81% across the journals). Among these articles, about half did report the underlying absolute risks elsewhere in the article (text, table, or figure) but half did not report them anywhere. Absolute risks were more likely to be reported in the abstract for randomised trials compared with cohort studies (62% v 21%; relative risk 3.0, 95% confidence interval 2.1 to 4.2) and for studies reporting crude compared with adjusted ratio measures (62% v 21%; relative risk 3.0, 2.1 to 4.3). Conclusion Absolute risks are often not easily accessible in articles reporting ratio measures and sometimes are missing altogether—this lack of accessibility can easily exaggerate readers' perceptions of benefit or harm. PMID:17060338

Global Location-Based Access to Web Applications Using Atom-Based Automatic Update

NASA Astrophysics Data System (ADS)

Singh, Kulwinder; Park, Dong-Won

We propose an architecture which enables people to enquire about information available in directory services by voice using regular phones. We implement a Virtual User Agent (VUA) which mediates between the human user and a business directory service. The system enables the user to search for the nearest clinic, gas station by price, motel by price, food / coffee, banks/ATM etc. and fix an appointment, or automatically establish a call between the user and the business party if the user prefers. The user also has an option to receive appointment confirmation by phone, SMS, or e-mail. The VUA is accessible by a toll free DID (Direct Inward Dialing) number using a phone by anyone, anywhere, anytime. We use the Euclidean formula for distance measurement. Since, shorter geodesic distances (on the Earth’s surface) correspond to shorter Euclidean distances (measured by a straight line through the Earth). Our proposed architecture uses Atom XML syndication format protocol for data integration, VoiceXML for creating the voice user interface (VUI) and CCXML for controlling the call components. We also provide an efficient algorithm for parsing Atom feeds which provide data to the system. Moreover, we describe a cost-effective way for providing global access to the VUA based on Asterisk (an open source IP-PBX). We also provide some information on how our system can be integrated with GPS for locating the user coordinates and therefore efficiently and spontaneously enhancing the system response. Additionally, the system has a mechanism for validating the phone numbers in its database, and it updates the number and other information such as daily price of gas, motel etc. automatically using an Atom-based feed. Currently, the commercial directory services (Example 411) do not have facilities to update the listing in the database automatically, so that why callers most of the times get out-of-date phone numbers or other information. Our system can be integrated very easily with an existing web infrastructure, thereby making the wealth of Web information easily available to the user by phone. This kind of system can be deployed as an extension to 911 and 411 services to share the workload with human operators. This paper presents all the underlying principles, architecture, features, and an example of the real world deployment of our proposed system. The source code and documentations are available for commercial productions.

Development of a mathematical model of the human cardiovascular system: An educational perspective

NASA Astrophysics Data System (ADS)

Johnson, Bruce Allen

A mathematical model of the human cardiovascular system will be a useful educational tool in biological sciences and bioengineering classrooms. The goal of this project is to develop a mathematical model of the human cardiovascular system that responds appropriately to variations of significant physical variables. Model development is based on standard fluid statics and dynamics principles, pressure-volume characteristics of the cardiac cycle, and compliant behavior of blood vessels. Cardiac cycle phases provide the physical and logical model structure, and Boolean algebra links model sections. The model is implemented using VisSim, a highly intuitive and easily learned block diagram modeling software package. Comparisons of model predictions of key variables to published values suggest that the model reasonably approximates expected behavior of those variables. The model responds plausibly to variations of independent variables. Projected usefulness of the model as an educational tool is threefold: independent variables which determine heart function may be easily varied to observe cause and effect; the model is used in an interactive setting; and the relationship of governing equations to model behavior is readily viewable and intuitive. Future use of this model in classrooms may give a more reasonable indication of its value as an educational tool.* *This dissertation includes a CD that is multimedia (contains text and other applications that are not available in a printed format). The CD requires the following applications: CorelPhotoHouse, CorelWordPerfect, VisSinViewer (included on CD), Internet access.

Immobilized heterobimetallic Ru/Co nanoparticle-catalyzed Pauson-Khand-type reactions in the presence of pyridylmethyl formate.

PubMed

Park, Kang Hyun; Son, Seung Uk; Chung, Young Keun

2003-08-07

Heterobimetallic Ru/Co nanoparticles, immobilized on charcoal, were synthesized and used as catalysts in the Pauson-Khand-type reaction in the presence of pyridylmethyl formate instead of carbon monoxide; the catalysts were effective for intra- and intermolecular reactions and easily reused without loss of catalytic activity.

Learning about Regiochemistry from a Hydrogen-Atom Abstraction Reaction in Water

ERIC Educational Resources Information Center

Sears-Dundes, Christopher; Huon, Yoeup; Hotz, Richard P.; Pinhas, Allan R.

2011-01-01

An experiment has been developed in which the hydrogen-atom abstraction and the coupling of propionitrile, using Fenton's reagent, are investigated. Students learn about the regiochemistry of radical formation, the stereochemistry of product formation, and the interpretation of GC-MS data, in a safe reaction that can be easily completed in one…

Herbal supplements: Research findings and safety.

PubMed

Pruitt, Rosanne; Lemanski, Ashley; Carroll, Adam

2018-05-17

Herbal supplements are used extensively worldwide without much awareness regarding their safety and efficacy. Extensive research to determine the safety, utility, and level of research support for commonly used herbs has culminated in an easily accessible summary chart for NP providers.

Developing a bike-sharing program at Kent State University and Kent, Ohio.

DOT National Transportation Integrated Search

2012-01-01

Sustainable transportation frequently describes the use of non-motorized transportation : sources, primarily walking and bicycling (Toor and Havlick, 2004). Walking is a time : honored method of getting around that most people can easily access. But ...

Leon M. Lederman Science Education Center: General Information

Science.gov Websites

field trips. Location: Located at Fermilab about 35 miles west of Chicago, the Center is easily accessible from the Fermilab main entrance at Kirk Road and Pine Street in Batavia, just three miles north of

An application programming interface for CellNetAnalyzer.

PubMed

Klamt, Steffen; von Kamp, Axel

2011-08-01

CellNetAnalyzer (CNA) is a MATLAB toolbox providing computational methods for studying structure and function of metabolic and cellular signaling networks. In order to allow non-experts to use these methods easily, CNA provides GUI-based interactive network maps as a means of parameter input and result visualization. However, with the availability of high-throughput data, there is a need to make CNA's functionality also accessible in batch mode for automatic data processing. Furthermore, as some algorithms of CNA are of general relevance for network analysis it would be desirable if they could be called as sub-routines by other applications. For this purpose, we developed an API (application programming interface) for CNA allowing users (i) to access the content of network models in CNA, (ii) to use CNA's network analysis capabilities independent of the GUI, and (iii) to interact with the GUI to facilitate the development of graphical plugins. Here we describe the organization of network projects in CNA and the application of the new API functions to these projects. This includes the creation of network projects from scratch, loading and saving of projects and scenarios, and the application of the actual analysis methods. Furthermore, API functions for the import/export of metabolic models in SBML format and for accessing the GUI are described. Lastly, two example applications demonstrate the use and versatile applicability of CNA's API. CNA is freely available for academic use and can be downloaded from http://www.mpi-magdeburg.mpg.de/projects/cna/cna.html. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Probing protein surface with a solvent mimetic carbene coupled to detection by mass spectrometry.

PubMed

Gómez, Gabriela E; Mundo, Mariana R; Craig, Patricio O; Delfino, José M

2012-01-01

Much knowledge into protein folding, ligand binding, and complex formation can be derived from the examination of the nature and size of the accessible surface area (SASA) of the polypeptide chain, a key parameter in protein science not directly measurable in an experimental fashion. To this end, an ideal chemical approach should aim at exerting solvent mimicry and achieving minimal selectivity to probe the protein surface regardless of its chemical nature. The choice of the photoreagent diazirine to fulfill these goals arises from its size comparable to water and from being a convenient source of the extremely reactive methylene carbene (:CH(2)). The ensuing methylation depends primarily on the solvent accessibility of the polypeptide chain, turning it into a valuable signal to address experimentally the measurement of SASA in proteins. The superb sensitivity and high resolution of modern mass spectrometry techniques allows us to derive a quantitative signal proportional to the extent of modification (EM) of the sample. Thus, diazirine labeling coupled to electrospray mass spectrometry (ESI-MS) detection can shed light on conformational features of the native as well as non-native states, not easily addressable by other methods. Enzymatic fragmentation of the polypeptide chain at the level of small peptides allows us to locate the covalent tag along the amino acid sequence, therefore enabling the construction of a map of solvent accessibility. Moreover, by subsequent MS/MS analysis of peptides, we demonstrate here the feasibility of attaining amino acid resolution in defining the target sites. © American Society for Mass Spectrometry, 2011

Access to MISR Aerosol Data and Imagery for the GoMACCS Field Study

NASA Astrophysics Data System (ADS)

Ritchey, N.; Watkinson, T.; Davis, J.; Walter, J.; Protack, S.; Matthews, J.; Smyth, M.; Rheingans, B.; Gaitley, B.; Ferebee, M.; Haberer, S.

2006-12-01

NASA Langley Atmospheric Science Data Center (ASDC) and NASA Jet Propulsion Laboratory (JPL) Multi- angle Imaging SpectroRadiometer (MISR) teams collaborated to provide special data products and images in an innovative approach for the Gulf of Mexico Atmospheric Composition and Climate Study (GoMACCS) field campaign. GoMACCS was an intensive field study focused on providing a better understanding of the sources and atmospheric processes responsible for the formation and distribution of ozone and aerosols in the atmosphere and the influence that these species have on the radiative forcing of regional and global climate, as well as their impact on human health and regional haze. The study area encompassed Texas and the northwestern Gulf of Mexico. Numerous U. S. Government agencies, universities and commercial entities participated in the field campaign which occurred August through September 2006. Aerosol and meteorological measurements were provided by a network of instruments on land, buoys and ships, by airborne in situ and remote instruments, and by satellite retrievals. MISR's role in GoMACCS was to provide satellite retrievals of aerosols and cloud properties and imagery as quickly as possible after data acquisition. The diverse group of scientific participants created unique opportunities for ASDC and MISR to develop special data products and images that were easily accessible by all participants. Examples of the data products, images and access methods as well as the data and imagery flow will be presented. Additional information about ASDC and MISR is available from the following web sites, http://eosweb.larc.nasa.gov and http://www-misr.jpl.nasa.gov/.

Data science implications in diamond formation and craton evolution

NASA Astrophysics Data System (ADS)

Pan, F.; Huang, F.; Fox, P. A.

2017-12-01

Diamonds are so-called "messengers" from the deep Earth. Fluid and mineral inclusions in diamonds could reflect the compositions of fluids/melts and wall-rocks in which diamond formed. Recently many diamond samples are examined to study the water content in the mantle transition zone1, the mechanism of diamond formation2 and the mantle evolution history3. However, most of the studies can only explain local activities. Therefore, an overall project of data grouping, comparison and correlation is needed, but limited progress has been made due to a lack of benchmark datasets on diamond formation and effective computing algorithms. In this study, we start by proposing the very first complete and easily-accessible dataset on mineral and fluid inclusions in diamonds. We rescue, collect and organize the data available from papers, journals and other publications resources ([2-4] and more), and then apply several state-of-the-art machine learning methods to tackle this earth science problem by clustering diamond formation process into distinct groups primarily based on the compositions, the formation temperature and pressure, the age and so on. Our ongoing work includes further data exploration and training existing models. Our preliminary results show that diamonds formed from older cratons usually have higher formation temperature. Also peridotitic diamonds take a much larger population than the ecologitic ones. More details are being discovered when we finish constructing the database and training our model. We expect the result to demonstrate the advantages of using machine learning and data science in earth science research problems. Our methodology for knowledge discovery are very general and can be broadly applied to other earth science research problems under the same framework.[1] Pearson et al, Nature (2014); [2] Tomlinson et al, EPSL (2006); [3] Weiss et al, Nature (2016); [4] Stachel and Harris, Ore Geology Reviews (2008); Weiss et al, EPSL (2013)

Web Services and Other Enhancements at the Northern California Earthquake Data Center

NASA Astrophysics Data System (ADS)

Neuhauser, D. S.; Zuzlewski, S.; Allen, R. M.

2012-12-01

The Northern California Earthquake Data Center (NCEDC) provides data archive and distribution services for seismological and geophysical data sets that encompass northern California. The NCEDC is enhancing its ability to deliver rapid information through Web Services. NCEDC Web Services use well-established web server and client protocols and REST software architecture to allow users to easily make queries using web browsers or simple program interfaces and to receive the requested data in real-time rather than through batch or email-based requests. Data are returned to the user in the appropriate format such as XML, RESP, or MiniSEED depending on the service, and are compatible with the equivalent IRIS DMC web services. The NCEDC is currently providing the following Web Services: (1) Station inventory and channel response information delivered in StationXML format, (2) Channel response information delivered in RESP format, (3) Time series availability delivered in text and XML formats, (4) Single channel and bulk data request delivered in MiniSEED format. The NCEDC is also developing a rich Earthquake Catalog Web Service to allow users to query earthquake catalogs based on selection parameters such as time, location or geographic region, magnitude, depth, azimuthal gap, and rms. It will return (in QuakeML format) user-specified results that can include simple earthquake parameters, as well as observations such as phase arrivals, codas, amplitudes, and computed parameters such as first motion mechanisms, moment tensors, and rupture length. The NCEDC will work with both IRIS and the International Federation of Digital Seismograph Networks (FDSN) to define a uniform set of web service specifications that can be implemented by multiple data centers to provide users with a common data interface across data centers. The NCEDC now hosts earthquake catalogs and waveforms from the US Department of Energy (DOE) Enhanced Geothermal Systems (EGS) monitoring networks. These data can be accessed through the above web services and through special NCEDC web pages.

An Open-source Toolbox for Analysing and Processing PhysioNet Databases in MATLAB and Octave.

PubMed

Silva, Ikaro; Moody, George B

The WaveForm DataBase (WFDB) Toolbox for MATLAB/Octave enables integrated access to PhysioNet's software and databases. Using the WFDB Toolbox for MATLAB/Octave, users have access to over 50 physiological databases in PhysioNet. The toolbox provides access over 4 TB of biomedical signals including ECG, EEG, EMG, and PLETH. Additionally, most signals are accompanied by metadata such as medical annotations of clinical events: arrhythmias, sleep stages, seizures, hypotensive episodes, etc. Users of this toolbox should easily be able to reproduce, validate, and compare results published based on PhysioNet's software and databases.

TheCellMap.org: A Web-Accessible Database for Visualizing and Mining the Global Yeast Genetic Interaction Network

PubMed Central

Usaj, Matej; Tan, Yizhao; Wang, Wen; VanderSluis, Benjamin; Zou, Albert; Myers, Chad L.; Costanzo, Michael; Andrews, Brenda; Boone, Charles

2017-01-01

Providing access to quantitative genomic data is key to ensure large-scale data validation and promote new discoveries. TheCellMap.org serves as a central repository for storing and analyzing quantitative genetic interaction data produced by genome-scale Synthetic Genetic Array (SGA) experiments with the budding yeast Saccharomyces cerevisiae. In particular, TheCellMap.org allows users to easily access, visualize, explore, and functionally annotate genetic interactions, or to extract and reorganize subnetworks, using data-driven network layouts in an intuitive and interactive manner. PMID:28325812

TheCellMap.org: A Web-Accessible Database for Visualizing and Mining the Global Yeast Genetic Interaction Network.

PubMed

Usaj, Matej; Tan, Yizhao; Wang, Wen; VanderSluis, Benjamin; Zou, Albert; Myers, Chad L; Costanzo, Michael; Andrews, Brenda; Boone, Charles

2017-05-05

Providing access to quantitative genomic data is key to ensure large-scale data validation and promote new discoveries. TheCellMap.org serves as a central repository for storing and analyzing quantitative genetic interaction data produced by genome-scale Synthetic Genetic Array (SGA) experiments with the budding yeast Saccharomyces cerevisiae In particular, TheCellMap.org allows users to easily access, visualize, explore, and functionally annotate genetic interactions, or to extract and reorganize subnetworks, using data-driven network layouts in an intuitive and interactive manner. Copyright © 2017 Usaj et al.

Aero-Propulsive Model Design from a Commercial Aircraft in Climb and Cruise Regime using Performance Data =

NASA Astrophysics Data System (ADS)

Tudor, Magdalena

IATA has estimated, in 2012, at about 2% of global carbon dioxide emissions, the environmental impact of the air transport, as a consequence caused by the rapidly growing of global movement demand of people and goods, and which was effectively taken into account in the development of the aviation industry. The historic achievements of scientific and technical progress in the field of commercial aviation were contributed to this estimate, and even today the research continues to make progress to help to reduce the emissions of greenhouse gases. Advances in commercial aircraft, and its engine design technology had the aim to improve flight performance. These improvements have enhanced the global flight planning of these types of aircrafts. Almost all of these advances rely on generated performance data as reference sources, the most of which are classified as "confidential" by the aircraft manufacturers. There are very few aero-propulsive models conceived for the climb regime in the literature, but none of them was designed without access to an engine database, and/or to performance data in climb and in cruise regimes with direct applicability for flight optimization. In this thesis, aero-propulsive models methodologies are proposed for climb and cruise regimes, using system identification and validation methods, through which airplane performance can be computed and stored in the most compact and easily accessible format for this kind of performance data. The acquiring of performance data in this format makes it possible to optimize flight profiles, used by on-board Flight Management Systems. The aero-propulsive models developed here were investigated on two aircrafts belonging to commercial class, and both of them had offered very good accuracy. One of their advantages is that they can be adapted to any other aircraft of the same class, even if there is no access to their corresponding engine flight data. In addition, these models could save airlines a considerable amount of money, given the fact that the number of flight tests could be drastically reduced. Lastly, academia, thus the laboratory of applied research in active control, avionics and aeroservoelasticity (LARCASE) team is gaining direct access to these aircraft performance data to obtain experience in novel optimization algorithms of flight profiles.

An Analysis of Website Accessibility in Higher Education in Indonesia Based on WCAG 2.0 Guidelines

NASA Astrophysics Data System (ADS)

Arasid, W.; Abdullah, A. G.; Wahyudin, D.; Abdullah, C. U.; Widiaty, I.; Zakaria, D.; Amelia, N.; Juhana, A.

2018-02-01

Website accessibility is a simple way to access a website by everyone so that information on the website can be easily understood. This study aims to improve the accessibility of universities’ website to analyze website accessibility problems based on WCAG 2.0 guidelines. This study analyzed 13 universities’ websites in West Java, Indonesia by using TAW as an evaluation tool. The evaluation results were presented in a graph showing the error rate of each university’s website. The same errors that occurred in almost all websites were: non-text content, info and relationships, page title, link purpose, language of page, on input, labels and instructions, parsing, and name, role, value criteria. This study was expected to provide information to the university and to perform as guidelines for website accessibility improvements.

OMERO and Bio-Formats 5: flexible access to large bioimaging datasets at scale

NASA Astrophysics Data System (ADS)

Moore, Josh; Linkert, Melissa; Blackburn, Colin; Carroll, Mark; Ferguson, Richard K.; Flynn, Helen; Gillen, Kenneth; Leigh, Roger; Li, Simon; Lindner, Dominik; Moore, William J.; Patterson, Andrew J.; Pindelski, Blazej; Ramalingam, Balaji; Rozbicki, Emil; Tarkowska, Aleksandra; Walczysko, Petr; Allan, Chris; Burel, Jean-Marie; Swedlow, Jason

2015-03-01

The Open Microscopy Environment (OME) has built and released Bio-Formats, a Java-based proprietary file format conversion tool and OMERO, an enterprise data management platform under open source licenses. In this report, we describe new versions of Bio-Formats and OMERO that are specifically designed to support large, multi-gigabyte or terabyte scale datasets that are routinely collected across most domains of biological and biomedical research. Bio- Formats reads image data directly from native proprietary formats, bypassing the need for conversion into a standard format. It implements the concept of a file set, a container that defines the contents of multi-dimensional data comprised of many files. OMERO uses Bio-Formats to read files natively, and provides a flexible access mechanism that supports several different storage and access strategies. These new capabilities of OMERO and Bio-Formats make them especially useful for use in imaging applications like digital pathology, high content screening and light sheet microscopy that create routinely large datasets that must be managed and analyzed.

Development of an IHE MRRT-compliant open-source web-based reporting platform.

PubMed

Pinto Dos Santos, Daniel; Klos, G; Kloeckner, R; Oberle, R; Dueber, C; Mildenberger, P

2017-01-01

To develop a platform that uses structured reporting templates according to the IHE Management of Radiology Report Templates (MRRT) profile, and to implement this platform into clinical routine. The reporting platform uses standard web technologies (HTML / JavaScript and PHP / MySQL) only. Several freely available external libraries were used to simplify the programming. The platform runs on a standard web server, connects with the radiology information system (RIS) and PACS, and is easily accessible via a standard web browser. A prototype platform that allows structured reporting to be easily incorporated into the clinical routine was developed and successfully tested. To date, 797 reports were generated using IHE MRRT-compliant templates (many of them downloaded from the RSNA's radreport.org website). Reports are stored in a MySQL database and are easily accessible for further analyses. Development of an IHE MRRT-compliant platform for structured reporting is feasible using only standard web technologies. All source code will be made available upon request under a free license, and the participation of other institutions in further development is welcome. • A platform for structured reporting using IHE MRRT-compliant templates is presented. • Incorporating structured reporting into clinical routine is feasible. • Full source code will be provided upon request under a free license.

Preserving and vouchering butterflies and moths for large-scale museum-based molecular research

PubMed Central

Epstein, Samantha W.; Mitter, Kim; Hamilton, Chris A.; Plotkin, David; Mitter, Charles

2016-01-01

Butterflies and moths (Lepidoptera) comprise significant portions of the world’s natural history collections, but a standardized tissue preservation protocol for molecular research is largely lacking. Lepidoptera have traditionally been spread on mounting boards to display wing patterns and colors, which are often important for species identification. Many molecular phylogenetic studies have used legs from pinned specimens as the primary source for DNA in order to preserve a morphological voucher, but the amount of available tissue is often limited. Preserving an entire specimen in a cryogenic freezer is ideal for DNA preservation, but without an easily accessible voucher it can make specimen identification, verification, and morphological work difficult. Here we present a procedure that creates accessible and easily visualized “wing vouchers” of individual Lepidoptera specimens, and preserves the remainder of the insect in a cryogenic freezer for molecular research. Wings are preserved in protective holders so that both dorsal and ventral patterns and colors can be easily viewed without further damage. Our wing vouchering system has been implemented at the University of Maryland (AToL Lep Collection) and the University of Florida (Florida Museum of Natural History, McGuire Center of Lepidoptera and Biodiversity), which are among two of the largest Lepidoptera molecular collections in the world. PMID:27366654

Astronaut Demographic Database: Everything You Want to Know About Astronauts and More

NASA Technical Reports Server (NTRS)

Keeton, Kathryn; Patterson, Holly

2011-01-01

A wealth of information regarding the astronaut population is available that could be especially useful to researchers. However, until now, it has been difficult to obtain that information in a systematic way. Therefore, this "astronaut database" began as a way for researchers within the Behavioral Health and Performance Group to keep track of the ever growing astronaut corps population. Before our effort, compilation of such data could be found, but not in a way that was easily acquired or accessible. One would have to use internet search engines, read through lengthy and potentially inaccurate informational sites, or read through astronaut biographies compiled by NASA. Astronauts are a unique class of individuals and, by examining such information, which we dubbed "Demographics," we hoped to find some commonalities that may be useful for other research areas and future research topics. By organizing the information pertaining to astronauts1 in a formal, unified catalog, we believe we have made the information more easily accessible, readily useable, and user friendly. Our end goal is to provide this database to others as a highly functional resource within the research community. Perhaps the database can eventually be an official, published document for researchers to gain full access.

14 CFR 23.901 - Installation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... maintenance. (c) Engine cowls and nacelles must be easily removable or openable by the pilot to provide adequate access to and exposure of the engine compartment for preflight checks. (d) Each turbine engine...

14 CFR 23.901 - Installation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... maintenance. (c) Engine cowls and nacelles must be easily removable or openable by the pilot to provide adequate access to and exposure of the engine compartment for preflight checks. (d) Each turbine engine...

14 CFR 23.901 - Installation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... maintenance. (c) Engine cowls and nacelles must be easily removable or openable by the pilot to provide adequate access to and exposure of the engine compartment for preflight checks. (d) Each turbine engine...

14 CFR 23.901 - Installation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... maintenance. (c) Engine cowls and nacelles must be easily removable or openable by the pilot to provide adequate access to and exposure of the engine compartment for preflight checks. (d) Each turbine engine...

14 CFR 23.901 - Installation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... maintenance. (c) Engine cowls and nacelles must be easily removable or openable by the pilot to provide adequate access to and exposure of the engine compartment for preflight checks. (d) Each turbine engine...

Data in Your Hands.

ERIC Educational Resources Information Center

Yeagley, Raymond

2001-01-01

A greater challenge than collecting and organizing data is transforming data into easily accessible, useful information that staff members can employ for school improvement. A New Hampshire district developed four guiding principles. They prioritized instructional change, instituted staff training, stressed communication of results, and invited…

Sustainable nano-catalysis

EPA Science Inventory

A novel nano-catalyst system which bridges the homogenous and heterogeneous system is described that is cheaper, easily accessible (sustainable) and requires no need of catalyst filtration during the work-up. Because of its nano-size, i.e. high surface area, the contact between r...

A Web-Based Database for Nurse Led Outreach Teams (NLOT) in Toronto.

PubMed

Li, Shirley; Kuo, Mu-Hsing; Ryan, David

2016-01-01

A web-based system can provide access to real-time data and information. Healthcare is moving towards digitizing patients' medical information and securely exchanging it through web-based systems. In one of Ontario's health regions, Nurse Led Outreach Teams (NLOT) provide emergency mobile nursing services to help reduce unnecessary transfers from long-term care homes to emergency departments. Currently the NLOT team uses a Microsoft Access database to keep track of the health information on the residents that they serve. The Access database lacks scalability, portability, and interoperability. The objective of this study is the development of a web-based database using Oracle Application Express that is easily accessible from mobile devices. The web-based database will allow NLOT nurses to enter and access resident information anytime and from anywhere.

[Digital pathology : The time has come!

PubMed

Grobholz, R

2018-05-01

Digital pathology (DP) and whole-slide imaging (WSI) technology have matured substantially over the last few years. Meanwhile, commercial systems are available that can be used in routine practice. Illustration of DP experiences in a routine diagnostic setting. A DP system offers several advantages: 1) glass slides are no longer unique; 2) access to cases is possible from any location; 3) digital image analysis can be applied; and 4) archived WSI can be easily accessed. From this point, several secondary advantages arise: a) the slide compilation of the case and the case assignment is fast and safe; b) carrying cases to the pathologist is obsolete and paperless work is possible; c) WSI can be used for a second opinion and be accessible in remote locations; d) WSI of referred cases are still accessible after returning the slides; e) histological images can easily be provided in tumor boards; f) the office desk is clean; and g) a "home office" is possible. To introduce a DP system, a comprehensive workflow analysis is needed that clarifies the needs and wishes of the respective institute. In order to optimally meet the requirements, open DP platforms are of particular advantage, because they enable the integration of scanners from various manufacturers. Further developments in image analysis, such as virtual tissue reconstruction, could enrich the diagnostic process in the future and improve treatment quality.

Proton-driven amide bond-cleavage pathways of gas-phase peptide ions lacking mobile protons.

PubMed

Bythell, Benjamin J; Suhai, Sándor; Somogyi, Arpád; Paizs, Béla

2009-10-07

The mobile proton model (Dongre, A. R., Jones, J. L., Somogyi, A. and Wysocki, V. H. J. Am. Chem. Soc. 1996, 118 , 8365-8374) of peptide fragmentation states that the ionizing protons play a critical role in the gas-phase fragmentation of protonated peptides upon collision-induced dissociation (CID). The model distinguishes two classes of peptide ions, those with or without easily mobilizable protons. For the former class mild excitation leads to proton transfer reactions which populate amide nitrogen protonation sites. This enables facile amide bond cleavage and thus the formation of b and y sequence ions. In contrast, the latter class of peptide ions contains strongly basic functionalities which sequester the ionizing protons, thereby often hindering formation of sequence ions. Here we describe the proton-driven amide bond cleavages necessary to produce b and y ions from peptide ions lacking easily mobilizable protons. We show that this important class of peptide ions fragments by different means from those with easily mobilizable protons. We present three new amide bond cleavage mechanisms which involve salt-bridge, anhydride, and imine enol intermediates, respectively. All three new mechanisms are less energetically demanding than the classical oxazolone b(n)-y(m) pathway. These mechanisms offer an explanation for the formation of b and y ions from peptide ions with sequestered ionizing protons which are routinely fragmented in large-scale proteomics experiments.

The Effects of Syntactically Parsed Text Formats on Intensive Reading in EFL

ERIC Educational Resources Information Center

Herbert, John C.

2014-01-01

Separating text into meaningful language chunks, as with visual-syntactic text formatting, helps readers to process text more easily and language learners to recognize grammar and syntax patterns more quickly. Evidence of this exists in studies on native and non-native English speakers. However, recent studies question the roll of VSTF in certain…

Radwaste desk reference - Volume 3, Part 2: Liquid waste management. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deltete, D.; Fisher, S.; Kelly, J.J.

1994-05-01

EPRI began, in late in 1987, to produce a Radwaste Desk Reference that would allow each of the member utilities access to the available information and expertise on radwaste management. EPRI considers this important because radwaste management involves a wide variety of scientific and engineering disciplines. These include chemical and mechanical engineering, chemistry, and health physics. Radwaste management also plays a role in implementing a wide variety of regulatory requirements. These include plant-specific technical specifications, NRC standards for protection against radiation, DOT transportation regulations and major environmental legislation such as the Resource Conservation and Recovery Act. EPRI chose a questionmore » and answer format because it could be easily accessed by radwaste professionals with a variety of interests. The questions were generated at two meetings of utility radwaste professionals and EPRI contractors. Volume 1, which is already in publication, addresses dry active waste generation, processing and measurement. Volume 2 addresses low level waste storage, transportation and disposal. This volume, Volume 3, is being issued in two parts. Part 1 concentrates on the processing of liquid radioactive waste, whereas Part 2, included here, addresses liquid waste management. It includes extensive information and operating practices related to liquid waste generation and control, liquid waste processing systems at existing U.S. nuclear plants, processes for managing wet wastes (handling, dewatering, solidifying, processing, and packaging), and liquid waste measurement and analysis.« less

Database for High Throughput Screening Hits (dHITS): a simple tool to retrieve gene specific phenotypes from systematic screens done in yeast.

PubMed

Chuartzman, Silvia G; Schuldiner, Maya

2018-03-25

In the last decade several collections of Saccharomyces cerevisiae yeast strains have been created. In these collections every gene is modified in a similar manner such as by a deletion or the addition of a protein tag. Such libraries have enabled a diversity of systematic screens, giving rise to large amounts of information regarding gene functions. However, often papers describing such screens focus on a single gene or a small set of genes and all other loci affecting the phenotype of choice ('hits') are only mentioned in tables that are provided as supplementary material and are often hard to retrieve or search. To help unify and make such data accessible, we have created a Database of High Throughput Screening Hits (dHITS). The dHITS database enables information to be obtained about screens in which genes of interest were found as well as the other genes that came up in that screen - all in a readily accessible and downloadable format. The ability to query large lists of genes at the same time provides a platform to easily analyse hits obtained from transcriptional analyses or other screens. We hope that this platform will serve as a tool to facilitate investigation of protein functions to the yeast community. © 2018 The Authors Yeast Published by John Wiley & Sons Ltd.

A Web-Based Decision Support System for Assessing Regional Water-Quality Conditions and Management Actions

NASA Astrophysics Data System (ADS)

Booth, N. L.; Everman, E.; Kuo, I.; Sprague, L.; Murphy, L.

2011-12-01

A new web-based decision support system has been developed as part of the U.S. Geological Survey (USGS) National Water Quality Assessment Program's (NAWQA) effort to provide ready access to Spatially Referenced Regressions On Watershed attributes (SPARROW) results of stream water-quality conditions and to offer sophisticated scenario testing capabilities for research and water-quality planning via an intuitive graphical user interface with a map-based display. The SPARROW Decision Support System (DSS) is delivered through a web browser over an Internet connection, making it widely accessible to the public in a format that allows users to easily display water-quality conditions, distribution of nutrient sources, nutrient delivery to downstream waterbodies, and simulations of altered nutrient inputs including atmospheric and agricultural sources. The DSS offers other features for analysis including various background map layers, model output exports, and the ability to save and share prediction scenarios. SPARROW models currently supported by the DSS are based on the modified digital versions of the 1:500,000-scale River Reach File (RF1) and 1:100,000-scale National Hydrography Dataset (medium-resolution, NHDPlus) stream networks. The underlying modeling framework and server infrastructure illustrate innovations in the information technology and geosciences fields for delivering SPARROW model predictions over the web by performing intensive model computations and map visualizations of the predicted conditions within the stream network.

ZBIT Bioinformatics Toolbox: A Web-Platform for Systems Biology and Expression Data Analysis

PubMed Central

Römer, Michael; Eichner, Johannes; Dräger, Andreas; Wrzodek, Clemens; Wrzodek, Finja; Zell, Andreas

2016-01-01

Bioinformatics analysis has become an integral part of research in biology. However, installation and use of scientific software can be difficult and often requires technical expert knowledge. Reasons are dependencies on certain operating systems or required third-party libraries, missing graphical user interfaces and documentation, or nonstandard input and output formats. In order to make bioinformatics software easily accessible to researchers, we here present a web-based platform. The Center for Bioinformatics Tuebingen (ZBIT) Bioinformatics Toolbox provides web-based access to a collection of bioinformatics tools developed for systems biology, protein sequence annotation, and expression data analysis. Currently, the collection encompasses software for conversion and processing of community standards SBML and BioPAX, transcription factor analysis, and analysis of microarray data from transcriptomics and proteomics studies. All tools are hosted on a customized Galaxy instance and run on a dedicated computation cluster. Users only need a web browser and an active internet connection in order to benefit from this service. The web platform is designed to facilitate the usage of the bioinformatics tools for researchers without advanced technical background. Users can combine tools for complex analyses or use predefined, customizable workflows. All results are stored persistently and reproducible. For each tool, we provide documentation, tutorials, and example data to maximize usability. The ZBIT Bioinformatics Toolbox is freely available at https://webservices.cs.uni-tuebingen.de/. PMID:26882475

Testing Quick Response (QR) Codes as an Innovation to Improve Feedback Among Geographically-Separated Clerkship Sites.

PubMed

Snyder, Matthew J; Nguyen, Dana R; Womack, Jasmyne J; Bunt, Christopher W; Westerfield, Katie L; Bell, Adriane E; Ledford, Christy J W

2018-03-01

Collection of feedback regarding medical student clinical experiences for formative or summative purposes remains a challenge across clinical settings. The purpose of this study was to determine whether the use of a quick response (QR) code-linked online feedback form improves the frequency and efficiency of rater feedback. In 2016, we compared paper-based feedback forms, an online feedback form, and a QR code-linked online feedback form at 15 family medicine clerkship sites across the United States. Outcome measures included usability, number of feedback submissions per student, number of unique raters providing feedback, and timeliness of feedback provided to the clerkship director. The feedback method was significantly associated with usability, with QR code scoring the highest, and paper second. Accessing feedback via QR code was associated with the shortest time to prepare feedback. Across four rotations, separate repeated measures analyses of variance showed no effect of feedback system on the number of submissions per student or the number of unique raters. The results of this study demonstrate that preceptors in the family medicine clerkship rate QR code-linked feedback as a high usability platform. Additionally, this platform resulted in faster form completion than paper or online forms. An overarching finding of this study is that feedback forms must be portable and easily accessible. Potential implementation barriers and the social norm for providing feedback in this manner need to be considered.

pvsR: An Open Source Interface to Big Data on the American Political Sphere.

PubMed

Matter, Ulrich; Stutzer, Alois

2015-01-01

Digital data from the political sphere is abundant, omnipresent, and more and more directly accessible through the Internet. Project Vote Smart (PVS) is a prominent example of this big public data and covers various aspects of U.S. politics in astonishing detail. Despite the vast potential of PVS' data for political science, economics, and sociology, it is hardly used in empirical research. The systematic compilation of semi-structured data can be complicated and time consuming as the data format is not designed for conventional scientific research. This paper presents a new tool that makes the data easily accessible to a broad scientific community. We provide the software called pvsR as an add-on to the R programming environment for statistical computing. This open source interface (OSI) serves as a direct link between a statistical analysis and the large PVS database. The free and open code is expected to substantially reduce the cost of research with PVS' new big public data in a vast variety of possible applications. We discuss its advantages vis-à-vis traditional methods of data generation as well as already existing interfaces. The validity of the library is documented based on an illustration involving female representation in local politics. In addition, pvsR facilitates the replication of research with PVS data at low costs, including the pre-processing of data. Similar OSIs are recommended for other big public databases.

Bibliography, geophysical data locations, and well core listings for the Mississippi Interior Salt Basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-05-01

To date, comprehensive basin analysis and petroleum system modeling studies have not been performed on any of the basins in the northeastern Gulf of Mexico. Of these basins, the Mississippi Interior Salt Basin has been selected for study because it is the most petroliferous basin in the northeastern Gulf of Mexico, small- and medium-size companies are drilling the majority of the exploration wells. These companies do not have the resources to perform basin analysis or petroleum system modeling research studies nor do they have the resources to undertake elaborate information searches through the volumes of publicly available data at themore » universities, geological surveys, and regulatory agencies in the region. The Advanced Geologic Basin Analysis Program of the US Department of Energy provides an avenue for studying and evaluating sedimentary basins. This program is designed to improve the efficiency of the discovery of the nation`s remaining undiscovered oil resources by providing improved access to information available in the public domain and by increasing the amount of public information on domestic basins. This report provides the information obtained from Year 1 of this study of the Mississippi Interior Salt Basin. The work during Year 1 focused on inventorying the data files and records of the major information repositories in the northeastern Gulf of Mexico and making these inventories easily accessible in an electronic format.« less

Informatics in radiology: A prototype Web-based reporting system for onsite-offsite clinician communication.

PubMed

Arnold, Corey W; Bui, Alex A T; Morioka, Craig; El-Saden, Suzie; Kangarloo, Hooshang

2007-01-01

The communication of imaging findings to a referring physician is an important role of the radiologist. However, communication between onsite and offsite physicians is a time-consuming process that can obstruct work flow and frequently involves no exchange of visual information, which is especially problematic given the importance of radiologic images for diagnosis and treatment. A prototype World Wide Web-based image documentation and reporting system was developed for use in supporting a "communication loop" that is based on the concept of a classic "wet-read" system. The proposed system represents an attempt to address many of the problems seen in current communication work flows by implementing a well-documented and easily accessible communication loop that is adaptable to different types of imaging study evaluation. Images are displayed in a native (DICOM) Digital Imaging and Communications in Medicine format with a Java applet, which allows accurate presentation along with use of various image manipulation tools. The Web-based infrastructure consists of a server that stores imaging studies and reports, with Web browsers that download and install necessary client software on demand. Application logic consists of a set of PHP (hypertext preprocessor) modules that are accessible with an application programming interface. The system may be adapted to any clinician-specialist communication loop, and, because it integrates radiologic standards with Web-based technologies, can more effectively communicate and document imaging data. RSNA, 2007

A Web-Based Decision Support System for Assessing Regional Water-Quality Conditions and Management Actions

USGS Publications Warehouse

Booth, N.L.; Everman, E.J.; Kuo, I.-L.; Sprague, L.; Murphy, L.

2011-01-01

The U.S. Geological Survey National Water Quality Assessment Program has completed a number of water-quality prediction models for nitrogen and phosphorus for the conterminous United States as well as for regional areas of the nation. In addition to estimating water-quality conditions at unmonitored streams, the calibrated SPAtially Referenced Regressions On Watershed attributes (SPARROW) models can be used to produce estimates of yield, flow-weighted concentration, or load of constituents in water under various land-use condition, change, or resource management scenarios. A web-based decision support infrastructure has been developed to provide access to SPARROW simulation results on stream water-quality conditions and to offer sophisticated scenario testing capabilities for research and water-quality planning via a graphical user interface with familiar controls. The SPARROW decision support system (DSS) is delivered through a web browser over an Internet connection, making it widely accessible to the public in a format that allows users to easily display water-quality conditions and to describe, test, and share modeled scenarios of future conditions. SPARROW models currently supported by the DSS are based on the modified digital versions of the 1:500,000-scale River Reach File (RF1) and 1:100,000-scale National Hydrography Dataset (medium-resolution, NHDPlus) stream networks. ?? 2011 American Water Resources Association. This article is a U.S. Government work and is in the public domain in the USA.

Improving Data Discovery, Access, and Analysis to More Than Three Decades of Oceanographic and Geomorphologic Observations

NASA Astrophysics Data System (ADS)

Forte, M.; Hesser, T.; Knee, K.; Ingram, I.; Hathaway, K. K.; Brodie, K. L.; Spore, N.; Bird, A.; Fratantonio, R.; Dopsovic, R.; Keith, A.; Gadomski, K.

2016-02-01

The U.S. Army Engineer Research and Development Center's (USACE ERDC) Coastal and Hydraulics Laboratory (CHL) Coastal Observations and Analysis Branch (COAB) Measurements Program has a 35-year record of coastal observations. These datasets include oceanographic point source measurements, Real-Time Kinematic (RTK) GPS bathymetry surveys, and remote sensing data from both the Field Research Facility (FRF) in Duck, NC and from other project and experiment sites around the nation. The data has been used to support a variety of USACE mission areas, including coastal wave model development, beach and bar response, coastal project design, coastal storm surge, and other coastal hazard investigations. Furthermore these data have been widely used by a number of federal and state agencies, academic institutions, and private industries in hundreds of scientific and engineering investigations, publications, conference presentations and model advancement studies. A limiting factor to the use of FRF data has been rapid, reliable access and publicly available metadata for each data type. The addition of web tools, accessible data files, and well-documented metadata will open the door to much future collaboration. With the help of industry partner RPS ASA and the U.S. Army Corps of Engineers Mobile District Spatial Data Branch, a Data Integration Framework (DIF) was developed. The DIF represents a combination of processes, standards, people, and tools used to transform disconnected enterprise data into useful, easily accessible information for analysis and reporting. A front-end data portal connects the user to the framework that integrates both oceanographic observation and geomorphology measurements using a combination of ESRI and open-source technology while providing a seamless data discovery, access, and analysis experience to the user. The user interface was built with ESRI's JavaScript API and all project metadata is managed using Geoportal. The geomorphology data is made available through ArcGIS Server, while the oceanographic data sets have been formatted to netCDF4 and made available through a THREDDS server. Additional web tools run alongside the THREDDS server to provide rapid statistical calculations and plotting, allowing for user defined data access and visualization.

"What Page, Miss?" Enhancing Text Accessibility with DAISY (Digital Accessible Information SYstem)

ERIC Educational Resources Information Center

Spooner, Sue

2014-01-01

Introduction: The provision of specially formatted materials is a complex and increasingly difficult task, given the extensive and burgeoning range of texts and resources available for classroom use. The need to extend the provision of accessible formats to include digital resources (in addition to braille, audio, and large print) led to a study…

Transparency

ERIC Educational Resources Information Center

LaFee, Scott

2009-01-01

Citizens now expect access to information, particularly from public institutions like local school districts. They demand input and accountability. Cultural and technological changes, such as the Internet, make it possible for districts to comply. Yet transparency--the easily seen and understood actions of a school district and the thinking behind…

The Sorghum Headworm Calculator: A speedy tool for headworm management

USDA-ARS?s Scientific Manuscript database

The Sorghum Headworm Calculator is an interactive decision support system for sorghum headworm management. It was designed to be easily accessible and usable. It provides users with organized information on identification, sampling, and management using images, descriptions and research-based mana...

An integrated study of pervious concrete mixture design for wearing course applications.

DOT National Transportation Integrated Search

2011-07-01

This report presents the results of the largest and most comprehensive study to date on portland cement pervious concrete (PCPC). It is designed to be widely accessible and easily applied by designers, producers, contractors, and owners. : The projec...

Evaluation of structure from motion for soil microtopography measurement

USDA-ARS?s Scientific Manuscript database

Recent developments in low cost structure from motion (SFM) technologies offer new opportunities for geoscientists to acquire high resolution soil microtopography data at a fraction of the cost of conventional techniques. However, these new methodologies often lack easily accessible error metrics an...

Dispelling myths about eggs.

USDA-ARS?s Scientific Manuscript database

With the rise of the “Google generation”, consumers can easily access information with a simple click. Unfortunately, this information is not always accurate or honest. This can pose many problems if consumer perception of your product is swayed by erroneous information. Being able to factually a...

Answering consumer questions.

USDA-ARS?s Scientific Manuscript database

With the rise of the “Google generation”, consumers can easily access information with a simple click. Unfortunately, this information is not always accurate or honest. This can pose many problems if consumer perception of your product is swayed by erroneous information. Being able to factually a...

Switch on Micro*scope!

ERIC Educational Resources Information Center

Roland, Sarah; Bahr, Michele; Olendzenski, Lorraine; Patterson, David J.

2005-01-01

Scientists at the Marine Biological Laboratory in Woods Hole, Massachusetts, have created micro*scope, a free, searchable knowledge environment for exploring the microbial world. Microbiology can easily be incorporated into the curriculum, because microbial communities are easy to access. Organisms grow quickly, making certain arrays of…

Das Deutschlandspiegelvideo (The View-of-Germany-Videos).

ERIC Educational Resources Information Center

Pentecost, Gislind E.

1993-01-01

Describes View-of-Germany-Videos, published by the Goethe Institute. The videos are authentic, entertaining, and very versatile in usefulness. In addition they are short, thus easily incorporated into a lesson plan, and free of charge, making them accessible to any educational establishment. (AB)

Usability Testing: A Case Study.

ERIC Educational Resources Information Center

Chisman, Janet; Walbridge, Sharon; Diller, Karen

1999-01-01

Discusses the development and results of usability testing of Washington State University's Web-based OPAC (online public access catalog); examines how easily users could navigate the catalog and whether they understood what they were seeing; and identifies problems and what action if any was taken. (LRW)

Clear as glass: transparent financial reporting.

PubMed

Valletta, Robert M

2005-08-01

To be transparent, financial information needs to be easily accessible, timely, content-rich, and narrative. Not-for-profit hospitals and health systems should report detailed financial information quarterly. They need internal controls to reduce the level of complexity throughout the organization by creating standardized processes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCord, Jason

WLS gathers all known relevant contextual data along with standard event log information, processes it into an easily consumable format for analysis by 3rd party tools, and forwards the logs to any compatible log server.

Implementing the HDF-EOS5 software library for data products in the UNAVCO InSAR archive

NASA Astrophysics Data System (ADS)

Baker, Scott; Meertens, Charles; Crosby, Christopher

2017-04-01

UNAVCO is a non-profit university-governed consortium that operates the U.S. National Science Foundation (NSF) Geodesy Advancing Geosciences and EarthScope (GAGE) facility and provides operational support to the Western North America InSAR Consortium (WInSAR). The seamless synthetic aperture radar archive (SSARA) is a seamless distributed access system for SAR data and higher-level data products. Under the NASA-funded SSARA project, a user-contributed InSAR archive for interferograms, time series, and other derived data products was developed at UNAVCO. The InSAR archive development has led to the adoption of the HDF-EOS5 data model, file format, and library. The HDF-EOS software library was designed to support NASA Earth Observation System (EOS) science data products and provides data structures for radar geometry (Swath) and geocoded (Grid) data based on the HDF5 data model and file format provided by the HDF Group. HDF-EOS5 inherits the benefits of HDF5 (open-source software support, internal compression, portability, support for structural data, self-describing file metadata enhanced performance, and xml support) and provides a way to standardize InSAR data products. Instrument- and datatype-independent services, such as subsetting, can be applied to files across a wide variety of data products through the same library interface. The library allows integration with GIS software packages such as ArcGIS and GDAL, conversion to other data formats like NetCDF and GeoTIFF, and is extensible with new data structures to support future requirements. UNAVCO maintains a GitHub repository that provides example software for creating data products from popular InSAR processing software packages like GMT5SAR and ISCE as well as examples for reading and converting the data products into other formats. Digital object identifiers (DOI) have been incorporated into the InSAR archive allowing users to assign a permanent location for their processed result and easily reference the final data products. A metadata attribute is added to the HDF-EOS5 file when a DOI is minted for a data product. These data products are searchable through the SSARA federated query providing access to processed data for both expert and non-expert InSAR users. The archive facilitates timely distribution of processed data with particular importance for geohazards and event response.

Classical vs. non-classical pathways of mineral formation (Invited)

NASA Astrophysics Data System (ADS)

De Yoreo, J. J.

2013-12-01

Recent chemical analyses, microscopy studies and computer simulations suggest many minerals nucleate through aggregation of pre-nucleation clusters and grow by particle-mediated processes that involve amorphous or disordered precursors. Still other analyses, both experimental and computational, conclude that even simple mineral systems like calcium carbonate form via a barrier-free process of liquid-liquid separation, which is followed by dehydration of the ion-rich phase to form the solid products. However, careful measurements of calcite nucleation rates on a variety of ionized surfaces give results that are in complete agreement with the expectations of classical nucleation theory, in which clusters growing through ion-by-ion addition overcome a free energy barrier through the natural microscopic density fluctuations of the system. Here the challenge of integrating these seemingly disparate observations and analyses into a coherent picture of mineral formation is addressed by considering the energy barriers to calcite formation predicted by the classical theory and the changes in those barriers brought about by the introduction of interfaces and clusters, both stable and metastable. Results from a suite of in situ TEM, AFM, and optical experiments combined with simulations are used to illustrate the conclusions. The analyses show that the expected barrier to homogeneous calcite nucleation is prohibitive even at concentrations exceeding the solubility limit of amorphous calcium carbonate. However, as demonstrated by experiments on self-assembled monolayers, the introduction of surfaces that moderately decrease the interfacial energy associated with the forming nucleus can reduce the magnitude of the barrier to a level that is easily surmounted under typical laboratory conditions. In the absence of such surfaces, experiments that proceed by continually increasing supersaturation with time can easily by-pass direct nucleation of calcite and open up pathways through all other solid phases, as well as dense liquid phases associated with a spinodal. Simulations predict that this phase boundary lies within the region of the calcium carbonate - water phase diagram accessible at room temperature. AFM and TEM analyses of other mineral systems, particularly calcium phosphate, suggest cluster aggregation can play important roles both in modifying barriers and in biasing pathways towards or away from amorphous phases. Most importantly, analysis of the energetic changes shows that barriers are only reduced if the clusters are metastable relative to the free ions and that the reduction is naturally accompanied by a bias towards formation of amorphous precursors. Finally, results from in situ TEM observations of nanoparticle interactions are used to understand the mechanisms controlling particle-mediated growth following formation of primary nuclei of either crystalline phases or disordered precursors. Measurements of the particle speeds and accelerations are used to estimate the magnitude of the attractive potential that drives particle-particle aggregation.

Tools for discovering and accessing Great Lakes scientific data

USGS Publications Warehouse

Lucido, Jessica M.; Bruce, Jennifer L.

2015-01-01

The USGS strives to develop data products that are easy to find, easy to understand, and easy to use through Web-accessible tools that allow users to learn about the breadth and scope of GLRI activities being undertaken by the USGS and its partners. By creating tools that enable data to be shared and reused more easily, the USGS can encourage collaboration and assist the GL community in finding, interpreting, and understanding the information created during GLRI science activities.

Wired and wireless convergent extended-reach optical access network using direct-detection of all-optical OFDM super-channel signal.

PubMed

Chow, C W; Yeh, C H; Sung, J Y; Hsu, C W

2014-12-15

We propose and demonstrate the feasibility of using all-optical orthogonal frequency division multiplexing (AO-OFDM) for the convergent optical wired and wireless access networks. AO-OFDM relies on all-optically generated orthogonal subcarriers; hence, high data rate (> 100 Gb/s) can be easily achieved without hitting the speed limit of electronic digital-to-analog and analog-to-digital converters (DAC/ADC). A proof-of-concept convergent access network using AO-OFDM super-channel (SC) is demonstrated supporting 40 - 100 Gb/s wired and gigabit/s 100 GHz millimeter-wave (MMW) ROF transmissions.

VARIABILITY AND CHARACTER ASSOCIATION IN ROSE COLOURED LEADWORT (PLUMBAGO ROSEA Linn.)

PubMed Central

Kurian, Alice; Anitha, C.A.; Nybe, E.V.

2001-01-01

Forty five plumbago rosea accessions collected from different parts of Kerala state were evaluated for variability in morphological and yield related characters and plumbagin content. Highly significant variation was evident for all the characters studied except leaf size indicating wide variability in the accessions. Accessions PR 25 and PR 31 appear to be promising with respect to root yield and high plumbagin content. Character association revelated significant and positive correlation of all the characters except leaf size with yield. Hence, selection of high yielding types could easily be done based on visual characters expressing more vegetative growth but with reduced leaf size. PMID:22557037

Elements of a next generation time-series ASCII data file format for Earth Sciences

NASA Astrophysics Data System (ADS)

Webster, C. J.

2015-12-01

Data in ASCII comma separated value (CSV) format are recognized as the most simple, straightforward and readable type of data present in the geosciences. Many scientific workflows developed over the years rely on data using this simple format. However, there is a need for a lightweight ASCII header format standard that is easy to create and easy to work with. Current OGC grade XML standards are complex and difficult to implement for researchers with few resources. Ideally, such a format should provide the data in CSV for easy consumption by generic applications such as spreadsheets. The format should use an existing time standard. The header should be easily human readable as well as machine parsable. The metadata format should be extendable to allow vocabularies to be adopted as they are created by external standards bodies. The creation of such a format will increase the productivity of software engineers and scientists because fewer translators and checkers would be required. Data in ASCII comma separated value (CSV) format are recognized as the most simple, straightforward and readable type of data present in the geosciences. Many scientific workflows developed over the years rely on data using this simple format. However, there is a need for a lightweight ASCII header format standard that is easy to create and easy to work with. Current OGC grade XML standards are complex and difficult to implement for researchers with few resources. Ideally, such a format would provide the data in CSV for easy consumption by generic applications such as spreadsheets. The format would use existing time standard. The header would be easily human readable as well as machine parsable. The metadata format would be extendable to allow vocabularies to be adopted as they are created by external standards bodies. The creation of such a format would increase the productivity of software engineers and scientists because fewer translators would be required.

Data Quality Assurance and Provenance Tracking in ICOADS Release 3.0

NASA Astrophysics Data System (ADS)

Cram, T.; Worley, S. J.; Ji, Z.; Schuster, D.

2017-12-01

The International Comprehensive Ocean-Atmosphere Data Set (ICOADS) Release 3.0 (R3.0) is the world's most extensive collection of global surface marine meteorological in situ observational data. Managed under an international partnership, it contains over 455 million unique multi-parameter records, dates back to 1662, and is updated monthly in near real-time. It is a foundational dataset for weather and climate research that has been used by thousands of users. By using rigorous data preparation methods, new IT infrastructure, and International Maritime Meteorological Archive (IMMA) format enhancements, ICOADS R3.0 is exemplary in data quality assurance, provenance tracking, and capturing user feedback. The features in this data lifecycle management will be presented and include, but are not limited to, written data translation specification for each data source being added to ICOADS, assignment of data source identification parameters, attachment of the original data in the IMMA format to support future re-evaluation if necessary, permanently assigned unique identification on every record making data development and community collaborations easily possible using a relational database infrastructure, and extensible capacity of the IMMA format to augment the data richness beyond the primary scope of marine surface data. Some recent augmentations are more completely specified ocean observations from profiling observing systems, feedback data submitted by the atmospheric and oceanographic reanalysis providers, higher quality edited cloud reports, and community provided data value adjustments with uncertainty estimates. Highlights covering these ICOADS value-added features will be explained and the open free access from NCAR will be briefly described.

What the Most Metal-poor Stars Tell Us About the Early Universe

NASA Astrophysics Data System (ADS)

Frebel, Anna

2008-05-01

The chemical evolution of the Galaxy and the early Universe is a key topic in modern astrophysics. The most metal-poor Galactic halo stars are now frequently used in an attempt to reconstruct the onset of the chemical and dynamical formation processes of the Galaxy. These stars are an easily-accessible local equivalent of the high-redshift Universe, and can thus be used to carry out field-field cosmology. The discovery of two astrophysically very important metal-poor objects has recently lead to a significant advance in the field. One object is the most iron-poor star yet found (with [Fe/H]=-5.4). The other stars displays the strongest known overabundances of heavy neutron-capture elements, such as uranium, and nucleo-chronometry yields a stellar age of 13 Gyr. Both stars already serve as benchmark objects for various theoretical studies with regard to nucleosynthesis processes in the early Galaxy. I will discuss how the abundance patterns of these and other metal-poor stars solidify and advance our understanding of the early Universe, and provide constraints on the nature of the first stars, as well as their explosion mechanisms and corresponding supernova nucleosynthesis yields. Large samples of these old objects are also employed to test theoretical predictions about the formation of the very first low-mass stars. In the near future, the combined power of near-field cosmology results with those of the next-generation facilities (e.g., MWA, JWST, GMT) may yield exceptional details about the formation processes of the first generations of stars and galaxies.

Hole-Center Locating Tool

NASA Technical Reports Server (NTRS)

Senter, H. F.

1984-01-01

Tool alines center of new hold with existing hole. Tool marks center of new hole drilled while workpiece is in place. Secured with bolts while hole center marked with punch. Used for field installations where reference points unavailable or work area cramped and not easily accessible with conventional tools.

Mathematics of Information Processing and the Internet

ERIC Educational Resources Information Center

Hart, Eric W.

2010-01-01

The mathematics of information processing and the Internet can be organized around four fundamental themes: (1) access (finding information easily); (2) security (keeping information confidential); (3) accuracy (ensuring accurate information); and (4) efficiency (data compression). In this article, the author discusses each theme with reference to…

Blended Learning: An Evolving Praxis

ERIC Educational Resources Information Center

Fogal, Gary G.; Graham, Floyd H., III.; Lavigne, Anthony G.

2014-01-01

TED (Technology Entertainment Design), a collection of regularly updated talks, offers a web-based platform that is easily accessible. This platform affords language learners across multiple proficiency levels an opportunity to develop autonomy and critical thinking skills alongside their second language (L2) development. With an international…

MedlinePlus FAQ: What's the difference between MedlinePlus and MedlinePlus Connect?

MedlinePlus

... MedlinePlus Connect is a free service that allows electronic health record (EHR) systems to easily link users to MedlinePlus, ... updates Subscribe to RSS Follow us Disclaimers Copyright Privacy Accessibility Quality Guidelines Viewers & Players MedlinePlus Connect for ...

REVISITING NUCLEOPHILIC SUBSTITUTION REACTIONS: MICROWAVE-ASSISTED SYNTHESIS OF AZIDES, THIOCYANATES AND SULFONES IN AQUEOUS MEDIUM

EPA Science Inventory

A practical, rapid and efficient microwave (MW) promoted synthesis of various azides, thiocyanates and sulfones, is described in aqueous medium. This general and expeditious MW-enhanced nucleophilic substitution approach uses easily accessible starting materials such as halides o...

Magnetic Nano-Materials: Truly Sustainable Green Chemistry Nano Catalysis

EPA Science Inventory

We envisioned a novel nano-catalyst system, which can bridge the homogenous and heterogeneous system, and simultaneously be cheaper, easily accessible (sustainable) and possibly does not require elaborate work-up. Because of its nano-size, i.e. high surface area, the contact betw...

FACETS: using open data to measure community social determinants of health.

PubMed

Cantor, Michael N; Chandras, Rajan; Pulgarin, Claudia

2018-04-01

To develop a dataset based on open data sources reflective of community-level social determinants of health (SDH). We created FACETS (Factors Affecting Communities and Enabling Targeted Services), an architecture that incorporates open data related to SDH into a single dataset mapped at the census-tract level for New York City. FACETS (https://github.com/mcantor2/FACETS) can be easily used to map individual addresses to their census-tract-level SDH. This dataset facilitates analysis across different determinants that are often not easily accessible. Wider access to open data from government agencies at the local, state, and national level would facilitate the aggregation and analysis of community-level determinants. Timeliness of updates to federal non-census data sources may limit their usefulness. FACETS is an important first step in standardizing and compiling SDH-related data in an open architecture that can give context to a patient's condition and enable better decision-making when developing a plan of care.

Cpf1-Database: web-based genome-wide guide RNA library design for gene knockout screens using CRISPR-Cpf1.

PubMed

Park, Jeongbin; Bae, Sangsu

2018-03-15

Following the type II CRISPR-Cas9 system, type V CRISPR-Cpf1 endonucleases have been found to be applicable for genome editing in various organisms in vivo. However, there are as yet no web-based tools capable of optimally selecting guide RNAs (gRNAs) among all possible genome-wide target sites. Here, we present Cpf1-Database, a genome-wide gRNA library design tool for LbCpf1 and AsCpf1, which have DNA recognition sequences of 5'-TTTN-3' at the 5' ends of target sites. Cpf1-Database provides a sophisticated but simple way to design gRNAs for AsCpf1 nucleases on the genome scale. One can easily access the data using a straightforward web interface, and using the powerful collections feature one can easily design gRNAs for thousands of genes in short time. Free access at http://www.rgenome.net/cpf1-database/. sangsubae@hanyang.ac.kr.

UUI: Reusable Spatial Data Services in Unified User Interface at NASA GES DISC

NASA Technical Reports Server (NTRS)

Petrenko, Maksym; Hegde, Mahabaleshwa; Bryant, Keith; Pham, Long B.

2016-01-01

Unified User Interface (UUI) is a next-generation operational data access tool that has been developed at Goddard Earth Sciences Data and Information Services Center(GES DISC) to provide a simple, unified, and intuitive one-stop shop experience for the key data services available at GES DISC, including subsetting (Simple Subset Wizard -SSW), granule file search (Mirador), plotting (Giovanni), and other legacy spatial data services. UUI has been built based on a flexible infrastructure of reusable web services self-contained building blocks that can easily be plugged into spatial applications, including third-party clients or services, to easily enable new functionality as new datasets and services become available. In this presentation, we will discuss our experience in designing UUI services based on open industry standards. We will also explain how the resulting framework can be used for a rapid development, deployment, and integration of spatial data services, facilitating efficient access and dissemination of spatial data sets.

MacroEvoLution: A New Method for the Rapid Generation of Novel Scaffold-Diverse Macrocyclic Libraries.

PubMed

Saupe, Jörn; Kunz, Oliver; Haustedt, Lars Ole; Jakupovic, Sven; Mang, Christian

2017-09-04

Macrocycles are a structural class bearing great promise for future challenges in medicinal chemistry. Nevertheless, there are few flexible approaches for the rapid generation of structurally diverse macrocyclic compound collections. Here, an efficient method for the generation of novel macrocyclic peptide-based scaffolds is reported. The process, named here as "MacroEvoLution", is based on a cyclization screening approach that gives reliable access to novel macrocyclic architectures. Classification of building blocks into specific pools ensures that scaffolds with orthogonally addressable functionalities are generated, which can easily be used for the generation of structurally diverse compound libraries. The method grants rapid access to novel scaffolds with scalable synthesis (multi gram scale) and the introduction of further diversity at a late stage. Despite being developed for peptidic systems, the approach can easily be extended for the synthesis of systems with a decreased peptidic character. © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

Using the Browser for Science: A Collaborative Toolkit for Astronomy

NASA Astrophysics Data System (ADS)

Connolly, A. J.; Smith, I.; Krughoff, K. S.; Gibson, R.

2011-07-01

Astronomical surveys have yielded hundreds of terabytes of catalogs and images that span many decades of the electromagnetic spectrum. Even when observatories provide user-friendly web interfaces, exploring these data resources remains a complex and daunting task. In contrast, gadgets and widgets have become popular in social networking (e.g. iGoogle, Facebook). They provide a simple way to make complex data easily accessible that can be customized based on the interest of the user. With ASCOT (an AStronomical COllaborative Toolkit) we expand on these concepts to provide a customizable and extensible gadget framework for use in science. Unlike iGoogle, where all of the gadgets are independent, the gadgets we develop communicate and share information, enabling users to visualize and interact with data through multiple, simultaneous views. With this approach, web-based applications for accessing and visualizing data can be generated easily and, by linking these tools together, integrated and powerful data analysis and discovery tools can be constructed.

Report to the Nation on Crime and Justice and Technical Appendix. Second Edition.

ERIC Educational Resources Information Center

Department of Justice, Washington, DC. Bureau of Justice Statistics.

This report on crime and justice aims to present statistical information in a format that can be easily understood by a nontechnical audience. It uses graphics and a nontechnical format to bring together data from the Bureau of Justice Statistics, the Federal Bureau of Investigation Uniform Crime Reports, the Bureau of the Census, the National…

METHOD OF SUPPRESSING UAl$sub 4$ FORMATION IN U-Al ALLOYS

DOEpatents

Picklesimer, M.L.; Thurber, W.C.

1960-08-23

A method is given for suppressing the formation of UAl/sub 4/ in uranium- - aluminum alloys, thereby rendering these alloys more easily workable. The method comprises incorporating in the base alloy a Group Four element selected from the group consisting of Si, Ti, Ge, Zr, and Sn, the addition preferably being within the range of 0.5to20at.%.

Use of Schema on Read in Earth Science Data Archives

NASA Technical Reports Server (NTRS)

Hegde, Mahabaleshwara; Smit, Christine; Pilone, Paul; Petrenko, Maksym; Pham, Long

2017-01-01

Traditionally, NASA Earth Science data archives have file-based storage using proprietary data file formats, such as HDF and HDF-EOS, which are optimized to support fast and efficient storage of spaceborne and model data as they are generated. The use of file-based storage essentially imposes an indexing strategy based on data dimensions. In most cases, NASA Earth Science data uses time as the primary index, leading to poor performance in accessing data in spatial dimensions. For example, producing a time series for a single spatial grid cell involves accessing a large number of data files. With exponential growth in data volume due to the ever-increasing spatial and temporal resolution of the data, using file-based archives poses significant performance and cost barriers to data discovery and access. Storing and disseminating data in proprietary data formats imposes an additional access barrier for users outside the mainstream research community. At the NASA Goddard Earth Sciences Data Information Services Center (GES DISC), we have evaluated applying the schema-on-read principle to data access and distribution. We used Apache Parquet to store geospatial data, and have exposed data through Amazon Web Services (AWS) Athena, AWS Simple Storage Service (S3), and Apache Spark. Using the schema-on-read approach allows customization of indexing spatially or temporally to suit the data access pattern. The storage of data in open formats such as Apache Parquet has widespread support in popular programming languages. A wide range of solutions for handling big data lowers the access barrier for all users. This presentation will discuss formats used for data storage, frameworks with This presentation will discuss formats used for data storage, frameworks with support for schema-on-read used for data access, and common use cases covering data usage patterns seen in a geospatial data archive.

Definition of Tire Properties Required for Landing System Analysis

NASA Technical Reports Server (NTRS)

Clark, S. K.; Dodge, R. N.; Luchini, J. R.

1978-01-01

The data bank constructed provided two basic advantages for the user of aircraft tire information. First, computerization of the data bank allowed mechanical property data to be stored, corrected, updated, and revised quickly and easily as more reliable tests and measurements were carried out. Secondly, the format of the book which can be printed from the computerized data bank can be easily adjusted to suit the needs of the users without the great expense normally associated with reprinting and editing books set by ordinary typography.

Efficient Access Control in Multimedia Social Networks

NASA Astrophysics Data System (ADS)

Sachan, Amit; Emmanuel, Sabu

Multimedia social networks (MMSNs) have provided a convenient way to share multimedia contents such as images, videos, blogs, etc. Contents shared by a person can be easily accessed by anybody else over the Internet. However, due to various privacy, security, and legal concerns people often want to selectively share the contents only with their friends, family, colleagues, etc. Access control mechanisms play an important role in this situation. With access control mechanisms one can decide the persons who can access a shared content and who cannot. But continuously growing content uploads and accesses, fine grained access control requirements (e.g. different access control parameters for different parts in a picture), and specific access control requirements for multimedia contents can make the time complexity of access control to be very large. So, it is important to study an efficient access control mechanism suitable for MMSNs. In this chapter we present an efficient bit-vector transform based access control mechanism for MMSNs. The proposed approach is also compatible with other requirements of MMSNs, such as access rights modification, content deletion, etc. Mathematical analysis and experimental results show the effectiveness and efficiency of our proposed approach.

Optimal Access to NASA Water Cycle Data for Water Resources Management

NASA Astrophysics Data System (ADS)

Teng, W. L.; Arctur, D. K.; Espinoza, G. E.; Rui, H.; Strub, R. F.; Vollmer, B.

2016-12-01

A "Digital Divide" in data representation exists between the preferred way of data access by the hydrology community (i.e., as time series of discrete spatial objects) and the common way of data archival by earth science data centers (i.e., as continuous spatial fields, one file per time step). This Divide has been an obstacle, specifically, between the Consortium of Universities for the Advancement of Hydrologic Science, Inc. Hydrologic Information System (CUAHSI HIS) and NASA Goddard Earth Sciences Data and Information Services Center (GES DISC). An optimal approach to bridging the Divide, developed by the GES DISC, is to reorganize data from the way they are archived to some way that is optimal for the desired method of data access. Specifically for CUAHSI HIS, selected data sets were reorganized into time series files, one per geographical "point." These time series files, termed "data rods," are pre-generated or virtual (generated on-the-fly). Data sets available as data rods include North American Land Data Assimilation System (NLDAS), Global Land Data Assimilation System (GLDAS), TRMM Multi-satellite Precipitation Analysis (TMPA), Land Parameter Retrieval Model (LPRM), Modern-Era Retrospective Analysis for Research and Applications (MERRA)-Land, and Groundwater and Soil Moisture Conditions from Gravity Recovery and Climate Experiment (GRACE) Data Assimilation drought indicators for North America Drought Monitor (GRACE-DA-DM). In order to easily avail the operational water resources community the benefits of optimally reorganized data, we have developed multiple methods of making these data more easily accessible and usable. These include direct access via RESTful Web services, a browser-based Web map and statistical tool for selected NLDAS variables for the U.S. (CONUS), a HydroShare app (Data Rods Explorer, under development) on the Tethys Platform, and access via the GEOSS Portal. Examples of drought-related applications of these data and data access methods are provided.

Earth-Base: A Free And Open Source, RESTful Earth Sciences Platform

NASA Astrophysics Data System (ADS)

Kishor, P.; Heim, N. A.; Peters, S. E.; McClennen, M.

2012-12-01

This presentation describes the motivation, concept, and architecture behind Earth-Base, a web-based, RESTful data-management, analysis and visualization platform for earth sciences data. Traditionally web applications have been built directly accessing data from a database using a scripting language. While such applications are great at bring results to a wide audience, they are limited in scope to the imagination and capabilities of the application developer. Earth-Base decouples the data store from the web application by introducing an intermediate "data application" tier. The data application's job is to query the data store using self-documented, RESTful URIs, and send the results back formatted as JavaScript Object Notation (JSON). Decoupling the data store from the application allows virtually limitless flexibility in developing applications, both web-based for human consumption or programmatic for machine consumption. It also allows outside developers to use the data in their own applications, potentially creating applications that the original data creator and app developer may not have even thought of. Standardized specifications for URI-based querying and JSON-formatted results make querying and developing applications easy. URI-based querying also allows utilizing distributed datasets easily. Companion mechanisms for querying data snapshots aka time-travel, usage tracking and license management, and verification of semantic equivalence of data are also described. The latter promotes the "What You Expect Is What You Get" (WYEIWYG) principle that can aid in data citation and verification.

MAMA User Guide v2.0.1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gaschen, Brian Keith; Bloch, Jeffrey Joseph; Porter, Reid

Morphological signatures of bulk SNM materials have significant promise, but these potential signatures are not fully utilized. This document describes software tools, collectively called the MAMA (Morphological Analysis for Material Attribution) software that can help provide robust and accurate quantification of morphological features in bulk material microscopy images (Optical, SEM). Although many of the specific tools are not unique to Mama, the software package has been designed specifically for nuclear material morphological analysis, and is at a point where it can be easily adapted (by Los Alamos or by collaborators) in response to new, different, or changing forensics needs. Themore » current release of the MAMA software only includes the image quantification, descriptions, and annotation functionality. Only limited information on a sample, its pedigree, and its chemistry are recorded inside this part of the software. This was decision based on initial feedback and the fact that there are several analytical chemistry databases being developed within the community. Currently MAMA is a standalone program that can export quantification results in a basic text format that can be imported into other programs such as Excel and Access. There is also a basic report generating feature that produces HTML formatted pages of the same information. We will be working with collaborators to provide better integration of MAMA into their particular systems, databases and workflows.« less

Iris Freckles a Potential Biomarker for Chronic Sun Damage.

PubMed

Schwab, Christoph; Mayer, Christoph; Zalaudek, Iris; Riedl, Regina; Richtig, Markus; Wackernagel, Werner; Hofmann-Wellenhof, Rainer; Richtig, Georg; Langmann, Gerald; Tarmann, Lisa; Wedrich, Andreas; Richtig, Erika

2017-05-01

To investigate the role of sunlight exposure in iris freckles formation. We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure. Six hundred thirty-two participants (n = 360; 57% female) were examined. Mean age of all participants was 38.4 ± 18.4 years (range, 4-84 years). Of all individuals, 76.1% (n = 481) exhibited at least one iris freckle. Most freckles were observed in the inferior temporal quadrant. The presence of iris freckles was associated with higher age (participants with iris freckles: 41.8 ± 16.8 years versus participants without iris freckles: 27.6 ± 19.2 years), a high number of sunburns during lifetime (>10: 31% vs. 19%), sunlight-damaged skin (26% vs. 11%), presence of actinic lentigines (72% vs. 45%), and a high total nevus body count (>10; 78% vs. 67%). The association of iris freckles, behavioral factors, and dermatologic findings, as well as the topographical distribution, indicate that sunlight exposure may trigger the formation of iris freckles. The evaluation of iris freckles offers an easily accessible potential biomarker, which might be helpful in indicating sun damage on the skin associated with cutaneous malignancies. Furthermore, the evaluation of iris freckles could also be helpful in understanding the role of sunlight in several ophthalmologic diseases.

45 CFR 164.524 - Access of individuals to protected health information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... individual with access to the protected health information in the form or format requested by the individual, if it is readily producible in such form or format; or, if not, in a readable hard copy form or such other form or format as agreed to by the covered entity and the individual. (ii) The covered entity may...

Novel azepino-perylenebisimides: synthesis, structure, and properties.

PubMed

Mishra, Ruchika; Panini, Piyush; Sankar, Jeyaraman

2014-08-01

The first example of an azepine ring formation by counterintuitive nucleophilic participation of DBU was observed at the sterically crowded bay area of electron-deficient perylenebisimide (PBI). This is also a rare example of the formation of a seven-membered ring via two consecutive C-N bond formations in a single step. Azepino-PBIs reveal panchromatic absorption covering the whole visible region. Further novelty of these PBIs lies within the fact that their photophysical characteristics can easily be modulated by suitable substituents.

U.S. Geological Survey National Computer Technology Meeting: Program and Abstracts, Norfolk, Virginia, May 17-22, 1992

DTIC Science & Technology

1992-05-01

formats, and character formats that can easily integrate graphics and text into one document. FrameMaker is one of few ERP software programs that has...easier and faster using ERP software. The DIS-II ERP software program is FrameMaker by Frame Technology, Incorporated. FrameMaker uses the X window...functions, calculus, relations, and other complicated math applications. FrameMaker permits the user to define formats for master pages, reference pages

Specifications of Standards in Systems and Synthetic Biology.

PubMed

Schreiber, Falk; Bader, Gary D; Golebiewski, Martin; Hucka, Michael; Kormeier, Benjamin; Le Novère, Nicolas; Myers, Chris; Nickerson, David; Sommer, Björn; Waltemath, Dagmar; Weise, Stephan

2015-09-04

Standards shape our everyday life. From nuts and bolts to electronic devices and technological processes, standardised products and processes are all around us. Standards have technological and economic benefits, such as making information exchange, production, and services more efficient. However, novel, innovative areas often either lack proper standards, or documents about standards in these areas are not available from a centralised platform or formal body (such as the International Standardisation Organisation). Systems and synthetic biology is a relatively novel area, and it is only in the last decade that the standardisation of data, information, and models related to systems and synthetic biology has become a community-wide effort. Several open standards have been established and are under continuous development as a community initiative. COMBINE, the ‘COmputational Modeling in BIology’ NEtwork has been established as an umbrella initiative to coordinate and promote the development of the various community standards and formats for computational models. There are yearly two meeting, HARMONY (Hackathons on Resources for Modeling in Biology), Hackathon-type meetings with a focus on development of the support for standards, and COMBINE forums, workshop-style events with oral presentations, discussion, poster, and breakout sessions for further developing the standards. For more information see http://co.mbine.org/. So far the different standards were published and made accessible through the standards’ web- pages or preprint services. The aim of this special issue is to provide a single, easily accessible and citable platform for the publication of standards in systems and synthetic biology. This special issue is intended to serve as a central access point to standards and related initiatives in systems and synthetic biology, it will be published annually to provide an opportunity for standard development groups to communicate updated specifications.

Advantages of combined touch screen technology and text hyperlink for the pathology grossing manual: a simple approach to access instructive information in biohazardous environments.

PubMed

Qu, Zhenhong; Ghorbani, Rhonda P; Li, Hongyan; Hunter, Robert L; Hannah, Christina D

2007-03-01

Gross examination, encompassing description, dissection, and sampling, is a complex task and an essential component of surgical pathology. Because of the complexity of the task, standardized protocols to guide the gross examination often become a bulky manual that is difficult to use. This problem is further compounded by the high specimen volume and biohazardous nature of the task. As a result, such a manual is often underused, leading to errors that are potentially harmful and time consuming to correct-a common chronic problem affecting many pathology laboratories. To combat this problem, we have developed a simple method that incorporates complex text and graphic information of a typical procedure manual and yet allows easy access to any intended instructive information in the manual. The method uses the Object-Linking-and-Embedding function of Microsoft Word (Microsoft, Redmond, WA) to establish hyperlinks among different contents, and then it uses the touch screen technology to facilitate navigation through the manual on a computer screen installed at the cutting bench with no need for a physical keyboard or a mouse. It takes less than 4 seconds to reach any intended information in the manual by 3 to 4 touches on the screen. A 3-year follow-up study shows that this method has increased use of the manual and has improved the quality of gross examination. The method is simple and can be easily tailored to different formats of instructive information, allowing flexible organization, easy access, and quick navigation. Increased compliance to instructive information reduces errors at the grossing bench and improves work efficiency.

Enabling Web-Based GIS Tools for Internet and Mobile Devices To Improve and Expand NASA Data Accessibility and Analysis Functionality for the Renewable Energy and Agricultural Applications

NASA Astrophysics Data System (ADS)

Ross, A.; Stackhouse, P. W.; Tisdale, B.; Tisdale, M.; Chandler, W.; Hoell, J. M., Jr.; Kusterer, J.

2014-12-01

The NASA Langley Research Center Science Directorate and Atmospheric Science Data Center have initiated a pilot program to utilize Geographic Information System (GIS) tools that enable, generate and store climatological averages using spatial queries and calculations in a spatial database resulting in greater accessibility of data for government agencies, industry and private sector individuals. The major objectives of this effort include the 1) Processing and reformulation of current data to be consistent with ESRI and openGIS tools, 2) Develop functions to improve capability and analysis that produce "on-the-fly" data products, extending these past the single location to regional and global scales. 3) Update the current web sites to enable both web-based and mobile application displays for optimization on mobile platforms, 4) Interact with user communities in government and industry to test formats and usage of optimization, and 5) develop a series of metrics that allow for monitoring of progressive performance. Significant project results will include the the development of Open Geospatial Consortium (OGC) compliant web services (WMS, WCS, WFS, WPS) that serve renewable energy and agricultural application products to users using GIS software and tools. Each data product and OGC service will be registered within ECHO, the Common Metadata Repository, the Geospatial Platform, and Data.gov to ensure the data are easily discoverable and provide data users with enhanced access to SSE data, parameters, services, and applications. This effort supports cross agency, cross organization, and interoperability of SSE data products and services by collaborating with DOI, NRCan, NREL, NCAR, and HOMER for requirements vetting and test bed users before making available to the wider public.

Sources of support for women experiencing obstetric fistula in northern Ghana: A focused ethnography.

PubMed

Sullivan, Ginger; O'Brien, Beverley; Mwini-Nyaledzigbor, Prudence

2016-09-01

we explored how women in northern Ghana who have or have had obstetric fistula and those close to them perceive support. focused ethnography, that includes in-depth interviews, participant observation, and scrutiny of relevant records. a fistula treatment centre in a regional urban centre and three remote villages located in northern Ghana. the sources of data included in-depth interview (n=14), non-participant observation and interaction, as well as scrutiny of relevant health records and documents. Participants for in-depth interviews and observation included women affected by obstetric fistula, their partners, parents, relatives, nurses and doctors. presentation of obstetric fistula information, particularly by Non-Governmental Organisations was not in a format that was readily understandable for many women and their families. Food and other basic requirements for daily living were not necessarily available in the fistula treatment centre. Travelling for care was costly and frequently not easily accessed from their communities. Fistula repair surgery was available at unpredictable times and only for a few days every one to two months. women perceived support from spouses/partner, family members, and other relatives but much of this is limited to tangible support. Perceptions of support were particularly focused on access to information and finances. the implementation of strategies to increase support for women living with obstetric fistula include improving access to fistula repair treatment, directing resources to create a dedicated specialist fistula centre located where most cases of OF occur and providing education to front-line workers. Strategies to prevent fistula as well as identify and support safe motherhood practices are needed for women affected by obstetric fistula. Copyright © 2016 Elsevier Ltd. All rights reserved.

Archiving Microgravity Flight Data and Samples

NASA Technical Reports Server (NTRS)

1996-01-01

To obtain help in evaluating its current strategy for archiving data and samples obtained in microgravity research, NASA's Microgravity Science and Applications Division (MSAD) asked the Space Studies Board's Committee on Microgravity Research for guidance on the following questions: What data should be archived and where should it be kept? In what form should the data be maintained (electronic files, photographs, hard copy, samples)? What should the general format of the database be? To what extent should it be universally accessible and through what mechanisms? Should there be a period of time for which principal investigators have proprietary access? If so, how long should proprietary data be stored? What provisions should be made for data obtained from ground-based experiments? What should the deadline be for investigators placing their data in the archive? How long should data be saved? How long should data be easily accessible? As a prelude to making recommendations for optimum selection and storage of microgravity data and samples, the committee in this report briefly describes NASA's past archiving practices and outlines MSAD's current archiving strategy. Although the committee found that only a limited number of experiments have thus far been archived, it concluded that the general archiving strategy, characterized by MSAD as minimalist, appears viable. A central focus of attention is the Experiment Data Management Plan (EDMP), MSAD's recently instituted data management and archiving framework for flight experiments. Many of the report's recommendations are aimed at enhancing the effectiveness of the EDMP approach, which the committee regards as an appropriate data management method for MSAD. Other recommendations provide guidance on broader issues related to the questions listed above. This report does not address statutory or regulatory records retention requirements.

Estuary Data Mapper: A virtual portal to coastal data informing environmental management decisions

EPA Science Inventory

The Estuary Data Mapper (EDM) is a free, interactive graphical application under development at the US EPA that allows environmental researchers and managers to quickly and easily retrieve, view and save subsets of online US coastal estuary-related data. Accessible data include ...

Creating the Future of Games and Learning

ERIC Educational Resources Information Center

Squire, Kurt

2015-01-01

Games for learning are poised to enter mainstream education. Several factors driving this movement are the following: (1) Digital distribution through cloud computing services and ubiquitous connectivity which will make digital learning tools--such as games--affordable and easily accessible; (2) The proliferation of digital devices; (3) Digital…

NASTRAN data deck generation on the PC

NASA Technical Reports Server (NTRS)

Guyan, R. J.

1986-01-01

Using two commercial programs an application was developed to aid in generating a run-ready NASTRAN data deck on the PC. Macros are used to access relevant reference material and card files while editing the deck. The application can be easily customized to suit individual or group needs.

Interdisciplinary Invitations: Exploring Gee's Bend Quilts

ERIC Educational Resources Information Center

Mitchell, Rebecca; Whitin, Phyllis; Whitin, David

2012-01-01

Engaging with the quilts of Gee's Bend offers a rich opportunity for students in grades four through eight to develop appreciation for pattern, rhythm, and innovation while learning about history, entrepreneurship, and political activism. By easily accessing print, film, and Internet resources teachers can include these vibrant quilts and…

Playing with Powers

ERIC Educational Resources Information Center

Sriraman, Bharath; Strzelecki, Pawel

2004-01-01

This paper explores the wide range of pure mathematics that becomes accessible through the use of problems involving powers. In particular we stress the need to balance an applied and context based pedagogical and curricular approach to mathematics with the powerful pure mathematics beneath the simplicity of easily stated and understandable…

Preparing for the Eclipse

ERIC Educational Resources Information Center

Hurst, Anna; Plummer, Julia; Gurton, Suzanne; Schatz, Dennis

2017-01-01

On August 21, 2017, sky gazers all across North America will experience a total solar eclipse, arguably the most breathtaking of all astronomical phenomena. The August eclipse is an ideal astronomical event to observe with young children because it allows them to observe a powerful and easily accessible astronomical phenomenon. Observing…

Starting Point: Pedagogic Resources for Teaching and Learning Economics

ERIC Educational Resources Information Center

Maier, Mark H.; McGoldrick, KimMarie; Simkins, Scott P.

2012-01-01

This article describes Starting Point: Teaching and Learning Economics, a Web-based portal that makes innovative pedagogic resources and effective teaching practices easily accessible to economists. Starting Point introduces economists to teaching innovations through 16 online modules, each containing a general description of a specific pedagogic…

Disaster easily averted? Data confidentiality and the hospital desktop computer.

PubMed

Sethi, Neeraj; Lane, Gethin; Newton, Sophie; Egan, Philip; Ghosh, Samit

2014-05-01

We specifically identified the hospital desktop computer as a potential source of breaches in confidentiality. We aimed to evaluate if there was accessible, unprotected, confidential information stored on the desktop screen on computers in a district general hospital and if so, how a teaching intervention could improve this situation. An unannounced spot check of 59 ward computers was performed. Data were collected regarding how many had confidential information stored on the desktop screen without any password protection. An online learning module was mandated for healthcare staff and a second cycle of inspection performed. A district general hospital. Two doctors conducted the audit. Computers in clinical areas were assessed. All clinical staff with computer access underwent the online learning module. An online learning module regarding data protection and confidentiality. In the first cycle, 55% of ward computers had easily accessible patient or staff confidential information stored on their desktop screen. This included handovers, referral letters, staff sick leave lists, audits and nursing reports. The majority (85%) of computers accessed were logged in under a generic username and password. The intervention produced an improvement in the second cycle findings with only 26% of computers being found to have unprotected confidential information stored on them. The failure to comply with appropriate confidential data protection regulations is a persistent problem. Education produces some improvement but we also propose a systemic approach to solving this problem. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Subarachnoid and basal cistern navigation through the sacral hiatus with guide wire assistance.

PubMed

Layer, Lauren; Riascos, Roy; Firouzbakht, Farhood; Amole, Adewumi; Von Ritschl, Rudiger; Dipatre, Pier; Cuellar, Hugo

2011-07-01

Intraspinal navigation with catheters and fiberscopes has shown feasible results for diagnosis and treatment of intraspinal and intracranial lesions. The most common approach, lumbar puncture, has allowed access to the spinal cord, however, coming with the difficulties of fiberscope damage and decreased torque for guidance. Our objective in this study is to allow an alternate access, the sacral hiatus, with guide wire assistance into the subarachnoid and intracranial structures, while easing the angle of entry and increasing torque. We advanced catheters with guide wire and fluoroscopy assistance into the sacral hiatus of three cadavers. After entry, the thecal sac was punctured and the catheter with guide wire was advanced rostrally until positioned in the basal cisterns of the brain. We confirmed catheter placement with contrast injection, autopsy, and dissection. In our study, the sacral hiatus was easily accessed, but resistance was found when attempting to puncture the thecal sac. The advancement of the catheter with guide wire assistance glided easily rostrally until some mild resistance was discovered at entry into the foramen magnum. With redirection, all catheters passed with ease into the basal cisterns. Positioning was confirmed with contrast injection with fluoroscopy evidence, autopsy, and dissection. There was no macroscopic or microscopic evidence of damage to the spinal roots, spinal cord, or cranial nerves. The sacral hiatus with guide wire assistance is an accessible conduit for uncomplicated entry into the subarachnoid and basal cistern space without damaging surrounding structures.

Europlanet/IDIS: Combining Diverse Planetary Observations and Models

NASA Astrophysics Data System (ADS)

Schmidt, Walter; Capria, Maria Teresa; Chanteur, Gerard

2013-04-01

Planetary research involves a diversity of research fields from astrophysics and plasma physics to atmospheric physics, climatology, spectroscopy and surface imaging. Data from all these disciplines are collected from various space-borne platforms or telescopes, supported by modelling teams and laboratory work. In order to interpret one set of data often supporting data from different disciplines and other missions are needed while the scientist does not always have the detailed expertise to access and utilize these observations. The Integrated and Distributed Information System (IDIS) [1], developed in the framework of the Europlanet-RI project, implements a Virtual Observatory approach ([2] and [3]), where different data sets, stored in archives around the world and in different formats, are accessed, re-formatted and combined to meet the user's requirements without the need of familiarizing oneself with the different technical details. While observational astrophysical data from different observatories could already earlier be accessed via Virtual Observatories, this concept is now extended to diverse planetary data and related model data sets, spectral data bases etc. A dedicated XML-based Europlanet Data Model (EPN-DM) [4] was developed based on data models from the planetary science community and the Virtual Observatory approach. A dedicated editor simplifies the registration of new resources. As the EPN-DM is a super-set of existing data models existing archives as well as new spectroscopic or chemical data bases for the interpretation of atmospheric or surface observations, or even modeling facilities at research institutes in Europe or Russia can be easily integrated and accessed via a Table Access Protocol (EPN-TAP) [5] adapted from the corresponding protocol of the International Virtual Observatory Alliance [6] (IVOA-TAP). EPN-TAP allows to search catalogues, retrieve data and make them available through standard IVOA tools if the access to the archive is compatible with IVOA standards. For some major data archives with different standards adaptation tools are available to make the access transparent to the user. EuroPlaNet-IDIS has contributed to the definition of PDAP, the Planetary Data Access Protocol of the International Planetary Data Alliance (IPDA) [7] to access the major planetary data archives of NASA in the USA [8], ESA in Europe [9] and JAXA in Japan [10]. Acknowledgement: Europlanet-RI was funded by the European Commission under the 7th Framework Program, grant 228319 "Capacities Specific Programme" - Research Infrastructures Action. Reference: [1] Details to IDIS and the Europlanet-RI via Web-site: http://www.idis.europlanet-ri.eu/ [2] Demonstrator implementation for Plasma-VO AMDA: http://cdpp-amda.cesr.fr/DDHTML/index.html [3] Demonstrator implementation for the IDIS-VO: http://www.idis-dyn.europlanet-ri.eu/vodev.shtml [4] Europlanet Data Model EPN-DM: http://www.europlanet-idis.fi/documents/public_documents/EPN-DM-v2.0.pdf [5] Europlanet Table Access Protocol EPN-TAP: http://www.europlanet-idis.fi/documents/public_documents/EPN-TAPV_0.26.pdf [6] International Virtual Observatory Alliance IVOA: http://www.ivoa.net [7] International Planetary Data Alliance IPDA: http://planetarydata.org/ [8] NASA's Planetary Data System: http://pds.jpl.nasa.gov/ [9] ESA's Planetary Science Archive PSA: http://www.sciops.esa.int/index.php?project=PSA [10] JAXAs Data Archive and Transmission System DARTS: http://darts.isas.jaxa.jp/

A simple, enaminone-based approach to some bicyclic pyridazinium tetrafluoroborates

PubMed Central

Josefík, František; Svobodová, Markéta; Bertolasi, Valerio

2013-01-01

Summary Easily obtainable cyclic enaminones (piperidin-2-ylidenealkanones) can be transformed into substituted bicyclic pyridazinium tetrafluoroborates upon treatment with corresponding diazonium salts. The transformation can be performed either in a one-pot way or in a two-step process with the isolation of single azo-coupled enaminone as the intermediate. The former method is superior. Under the optimized conditions, a number of pyridazinium salts substituted with both electron-donating and electron-withdrawing substituents was easily synthesized. A mechanism of the formation of the pyridazinium salts is suggested. A partial drawback is the possibility of the formation of a mixture of products when using a different diazonium salt in each step due to a reversibility of the azo coupling. This can be suppressed by using a more reactive diazonium salt before a less reactive one. PMID:23946844

SPSmart: adapting population based SNP genotype databases for fast and comprehensive web access.

PubMed

Amigo, Jorge; Salas, Antonio; Phillips, Christopher; Carracedo, Angel

2008-10-10

In the last five years large online resources of human variability have appeared, notably HapMap, Perlegen and the CEPH foundation. These databases of genotypes with population information act as catalogues of human diversity, and are widely used as reference sources for population genetics studies. Although many useful conclusions may be extracted by querying databases individually, the lack of flexibility for combining data from within and between each database does not allow the calculation of key population variability statistics. We have developed a novel tool for accessing and combining large-scale genomic databases of single nucleotide polymorphisms (SNPs) in widespread use in human population genetics: SPSmart (SNPs for Population Studies). A fast pipeline creates and maintains a data mart from the most commonly accessed databases of genotypes containing population information: data is mined, summarized into the standard statistical reference indices, and stored into a relational database that currently handles as many as 4 x 10(9) genotypes and that can be easily extended to new database initiatives. We have also built a web interface to the data mart that allows the browsing of underlying data indexed by population and the combining of populations, allowing intuitive and straightforward comparison of population groups. All the information served is optimized for web display, and most of the computations are already pre-processed in the data mart to speed up the data browsing and any computational treatment requested. In practice, SPSmart allows populations to be combined into user-defined groups, while multiple databases can be accessed and compared in a few simple steps from a single query. It performs the queries rapidly and gives straightforward graphical summaries of SNP population variability through visual inspection of allele frequencies outlined in standard pie-chart format. In addition, full numerical description of the data is output in statistical results panels that include common population genetics metrics such as heterozygosity, Fst and In.

The Gene Set Builder: collation, curation, and distribution of sets of genes

PubMed Central

Yusuf, Dimas; Lim, Jonathan S; Wasserman, Wyeth W

2005-01-01

Background In bioinformatics and genomics, there are many applications designed to investigate the common properties for a set of genes. Often, these multi-gene analysis tools attempt to reveal sequential, functional, and expressional ties. However, while tremendous effort has been invested in developing tools that can analyze a set of genes, minimal effort has been invested in developing tools that can help researchers compile, store, and annotate gene sets in the first place. As a result, the process of making or accessing a set often involves tedious and time consuming steps such as finding identifiers for each individual gene. These steps are often repeated extensively to shift from one identifier type to another; or to recreate a published set. In this paper, we present a simple online tool which – with the help of the gene catalogs Ensembl and GeneLynx – can help researchers build and annotate sets of genes quickly and easily. Description The Gene Set Builder is a database-driven, web-based tool designed to help researchers compile, store, export, and share sets of genes. This application supports the 17 eukaryotic genomes found in version 32 of the Ensembl database, which includes species from yeast to human. User-created information such as sets and customized annotations are stored to facilitate easy access. Gene sets stored in the system can be "exported" in a variety of output formats – as lists of identifiers, in tables, or as sequences. In addition, gene sets can be "shared" with specific users to facilitate collaborations or fully released to provide access to published results. The application also features a Perl API (Application Programming Interface) for direct connectivity to custom analysis tools. A downloadable Quick Reference guide and an online tutorial are available to help new users learn its functionalities. Conclusion The Gene Set Builder is an Ensembl-facilitated online tool designed to help researchers compile and manage sets of genes in a user-friendly environment. The application can be accessed via . PMID:16371163

Electronic medical archives: a different approach to applying re-signing mechanisms to digital signatures.

PubMed

Chen, Tzer-Long; Lin, Frank Y S

2011-08-01

Electronic medical records can be defined as a digital format of the traditionally paper-based anamneses, which contains the history of a patient such as his somewhat illness, current health problems, and his chronic treatments. An electronic anamnesis is meant to make the patient's health information more conveniently accessible and transferable between different medical institutions and also easier to be kept quite a long time. Because of such transferability and accessibility of electronic anamneses, we can use less resource than before on storing the patients' medical information. This also means that medical care providers could save more funds on record-keeping and access a patient's medical background directly since shown on the computer screen more quickly and easily. Overall, the service quality has seemingly improved greatly. However, the usage of electronic anamneses involves in some concerned issues such as its related law declaration, and the security of the patient's confidential information. Because of these concerns, a secure medical networking scheme is taking into consideration. Nowadays, the administrators at the medical institutions are facing more challenges on monitoring computers and network systems, because of dramatic advances in this field. For instance, a trusted third party is authorized to access some medical records for a certain period of time. In regard to the security purpose, all the electronic medical records are embedded with both of the public-key infrastructure (PKI) cryptography and the digital signature technique so as to ensure the records well-protected. Since the signatures will be invalid due to the revocation or time expiration, the security of records under this premise would turn into vulnerable. Hence, we propose a re-signing scheme, whose purpose is to make a going-expired digital signature been resigned in time, in keeping with the premise of not conflicting with the laws, morals, and privacy while maintaining the security of the electronic medical records.

Using open-source programs to create a web-based portal for hydrologic information

NASA Astrophysics Data System (ADS)

Kim, H.

2013-12-01

Some hydrologic data sets, such as basin climatology, precipitation, and terrestrial water storage, are not easily obtainable and distributable due to their size and complexity. We present a Hydrologic Information Portal (HIP) that has been implemented at the University of California for Hydrologic Modeling (UCCHM) and that has been organized around the large river basins of North America. This portal can be easily accessed through a modern web browser that enables easy access and visualization of such hydrologic data sets. Some of the main features of our HIP include a set of data visualization features so that users can search, retrieve, analyze, integrate, organize, and map data within large river basins. Recent information technologies such as Google Maps, Tornado (Python asynchronous web server), NumPy/SciPy (Scientific Library for Python) and d3.js (Visualization library for JavaScript) were incorporated into the HIP to create ease in navigating large data sets. With such open source libraries, HIP can give public users a way to combine and explore various data sets by generating multiple chart types (Line, Bar, Pie, Scatter plot) directly from the Google Maps viewport. Every rendered object such as a basin shape on the viewport is clickable, and this is the first step to access the visualization of data sets.

An easily accessible sulfated saccharide mimetic inhibits in vitro human tumor cell adhesion and angiogenesis of vascular endothelial cells

PubMed Central

Marano, Grazia; Gronewold, Claas; Frank, Martin; Merling, Anette; Kliem, Christian; Sauer, Sandra; Wiessler, Manfred; Frei, Eva

2012-01-01

Summary Oligosaccharides aberrantly expressed on tumor cells influence processes such as cell adhesion and modulation of the cell’s microenvironment resulting in an increased malignancy. Schmidt’s imidate strategy offers an effective method to synthesize libraries of various oligosaccharide mimetics. With the aim to perturb interactions of tumor cells with extracellular matrix proteins and host cells, molecules with 3,4-bis(hydroxymethyl)furan as core structure were synthesized and screened in biological assays for their abilities to interfere in cell adhesion and other steps of the metastatic cascade, such as tumor-induced angiogenesis. The most active compound, (4-{[(β-D-galactopyranosyl)oxy]methyl}furan-3-yl)methyl hydrogen sulfate (GSF), inhibited the activation of matrix-metalloproteinase-2 (MMP-2) as well as migration of the human melanoma cells of the lines WM-115 and WM-266-4 in a two-dimensional migration assay. GSF inhibited completely the adhesion of WM-115 cells to the extracellular matrix (ECM) proteins, fibrinogen and fibronectin. In an in vitro angiogenesis assay with human endothelial cells, GSF very effectively inhibited endothelial tubule formation and sprouting of blood vessels, as well as the adhesion of endothelial cells to ECM proteins. GSF was not cytotoxic at biologically active concentrations; neither were 3,4-bis{[(β-D-galactopyranosyl)oxy]methyl}furan (BGF) nor methyl β-D-galactopyranoside nor 3,4-bis(hydroxymethyl)furan, which were used as controls, eliciting comparable biological activity. In silico modeling experiments, in which binding of GSF to the extracellular domain of the integrin αvβ3 was determined, revealed specific docking of GSF to the same binding site as the natural peptidic ligands of this integrin. The sulfate in the molecule coordinated with one manganese ion in the binding site. These studies show that this chemically easily accessible molecule GSF, synthesized in three steps from 3,4-bis(hydroxymethyl)furan and benzoylated galactose imidate, is nontoxic and antagonizes cell physiological processes in vitro that are important for the dissemination and growth of tumor cells in vivo. PMID:23015827

Hands-on Activities for Exploring the Solar System in K-14 Formal and Informal Education Settings

NASA Astrophysics Data System (ADS)

Allen, J. S.; Tobola, K. W.

2004-12-01

Introduction: Activities developed by NASA scientists and teachers focus on integrating Planetary Science activities with existing Earth science, math, and language arts curriculum. Educators may choose activities that fit a particular concept or theme within their curriculum from activities that highlight missions and research pertaining to exploring the solar system. Most of the activities use simple, inexpensive techniques that help students understand the how and why of what scientists are learning about comets, asteroids, meteorites, moons and planets. The web sites for the activities contain current information so students experience recent mission information such as data from Mars rovers or the status of Stardust sample return. The Johnson Space Center Astromaterials Research and Exploration Science education team has compiled a variety of NASA solar system activities to produce an annotated thematic syllabus useful to classroom educators and informal educators as they teach space science. An important aspect of the syllabus is that it highlights appropriate science content information and key science and math concepts so educators can easily identify activities that will enhance curriculum development. The outline contains URLs for the activities and NASA educator guides as well as links to NASA mission science and technology. In the informal setting, educators can use solar system exploration activities to reinforce learning in association with thematic displays, planetarium programs, youth group gatherings, or community events. In both the informal and the primary education levels the activities are appropriately designed to excite interest, arouse curiosity and easily take the participants from pre-awareness to the awareness stage. Middle school educators will find activities that enhance thematic science and encourage students to think about the scientific process of investigation. Some of the activities offered may easily be adapted for the upper levels of high school and early college, as they require students to use and analyze data. Syllabus Format: The Exploring the Solar System Syllabus of Activities starts with a variety of solar system scale activities that fit different settings and equipment. The early solar system formation activities are focused on asteroids, meteorites and planet formation. The theme of how and why we explore our solar system encompasses activities that engage the language and creative arts. Further activities highlight the Sun and planetary geology. A key aspect of the usefulness of the syllabus is that it provides easy access to solar system content, activities, related links and the thematic context for the classroom teacher or group leader. Conclusion: The Exploring the Solar System Syllabus of Activities is a concentrated resource of activities and links that allows educators to comfortably and inexpensively share the excitement and science of solar system exploration with students and members of the public. Additional Information: Some of the activities included in the Exploring the Solar System Syllabus of Activities are in the following NASA developed guides. http://ares.jsc.nasa.gov/Education/index.html

Design of Accelerator Online Simulator Server Using Structured Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen, Guobao; /Brookhaven; Chu, Chungming

2012-07-06

Model based control plays an important role for a modern accelerator during beam commissioning, beam study, and even daily operation. With a realistic model, beam behaviour can be predicted and therefore effectively controlled. The approach used by most current high level application environments is to use a built-in simulation engine and feed a realistic model into that simulation engine. Instead of this traditional monolithic structure, a new approach using a client-server architecture is under development. An on-line simulator server is accessed via network accessible structured data. With this approach, a user can easily access multiple simulation codes. This paper describesmore » the design, implementation, and current status of PVData, which defines the structured data, and PVAccess, which provides network access to the structured data.« less

Arteriovenous Hybrid Graft with Outflow in the Proximal Axillary Vein.

PubMed

Murga, Allen G; Chiriano, Jason; Kiang, Sharon C; Patel, Sheela; Bianchi, Christian; Abou-Zamzam, Ahmed M; Teruya, Theodore H

2017-07-01

The patency of long-term hemodialysis access in end-stage renal disease patients remains a significant challenge. Often these patients are affected with limited venous outflow options, requiring limb abandonment, and creation of new access in the contralateral arm. Vascular surgeons are familiar with the exposure of the proximal axillary artery via an infraclavicular incision. The axillary vein is easily exposed through this technique. The use of the hybrid Gore graft can make the venous anastomosis easier. A hybrid graft with its venous outflow placed in the proximal axillary vein can extend the options of upper extremity access procedures. We reviewed our early experience with this technique. A review of dialysis procedures at the Loma Linda VA was performed. All patients undergoing placement of arteriovenous grafts utilizing the Gore hybrid placed into the proximal axillary vein for outflow were identified. Outcomes in terms of primary and secondary patency rates were determined. Eight patients had placement of an arteriovenous hybrid graft in the proximal axillary vein via an infraclavicular incision. All patients had exhausted other options for hemodialysis access in the ipsilateral upper extremity. All grafts were used successfully for dialysis. The mean primary and secondary patency rates at 6 months were 37.5% and 62.5%, respectively. One patient developed steal syndrome, requiring proximalization of the graft. Seven out of the 8 patients required secondary procedures including thrombectomy (n = 16) and angioplasty (n = 17). Placement of a hybrid graft in the proximal axillary vein is an effective and suitable option for patients who have exhausted arteriovenous access sites in the arm. This procedure can easily be performed in an outpatient setting with a low complication rate and allowing for preservation of the contralateral upper extremity for future use. Published by Elsevier Inc.

Binary Alkali-Metal Silicon Clathrates by Spark Plasma Sintering: Preparation and Characterization

PubMed Central

Veremchuk, Igor; Beekman, Matt; Antonyshyn, Iryna; Schnelle, Walter; Baitinger, Michael; Nolas, George S.; Grin, Yuri

2016-01-01

The binary intermetallic clathrates K8-xSi46 (x = 0.4; 1.2), Rb6.2Si46, Rb11.5Si136 and Cs7.8Si136 were prepared from M4Si4 (M = K, Rb, Cs) precursors by spark-plasma route (SPS) and structurally characterized by Rietveld refinement of PXRD data. The clathrate-II phase Rb11.5Si136 was synthesized for the first time. Partial crystallographic site occupancy of the alkali metals, particularly for the smaller Si20 dodecahedra, was found in all compounds. SPS preparation of Na24Si136 with different SPS current polarities and tooling were performed in order to investigate the role of the electric field on clathrate formation. The electrical and thermal transport properties of K7.6Si46 and K6.8Si46 in the temperature range 4–700 K were investigated. Our findings demonstrate that SPS is a novel tool for the synthesis of intermetallic clathrate phases that are not easily accessible by conventional synthesis techniques. PMID:28773710

Designing Summer Research Experiences for Teachers and Students That Promote Classroom Science Inquiry Projects and Produce Research Results

NASA Astrophysics Data System (ADS)

George, L. A.; Parra, J.; Rao, M.; Offerman, L.

2007-12-01

Research experiences for science teachers are an important mechanism for increasing classroom teachers' science content knowledge and facility with "real world" research processes. We have developed and implemented a summer scientific research and education workshop model for high school teachers and students which promotes classroom science inquiry projects and produces important research results supporting our overarching scientific agenda. The summer training includes development of a scientific research framework, design and implementation of preliminary studies, extensive field research and training in and access to instruments, measurement techniques and statistical tools. The development and writing of scientific papers is used to reinforce the scientific research process. Using these skills, participants collaborate with scientists to produce research quality data and analysis. Following the summer experience, teachers report increased incorporation of research inquiry in their classrooms and student participation in science fair projects. This workshop format was developed for an NSF Biocomplexity Research program focused on the interaction of urban climates, air quality and human response and can be easily adapted for other scientific research projects.

EviNet: a web platform for network enrichment analysis with flexible definition of gene sets.

PubMed

Jeggari, Ashwini; Alekseenko, Zhanna; Petrov, Iurii; Dias, José M; Ericson, Johan; Alexeyenko, Andrey

2018-06-09

The new web resource EviNet provides an easily run interface to network enrichment analysis for exploration of novel, experimentally defined gene sets. The major advantages of this analysis are (i) applicability to any genes found in the global network rather than only to those with pathway/ontology term annotations, (ii) ability to connect genes via different molecular mechanisms rather than within one high-throughput platform, and (iii) statistical power sufficient to detect enrichment of very small sets, down to individual genes. The users' gene sets are either defined prior to upload or derived interactively from an uploaded file by differential expression criteria. The pathways and networks used in the analysis can be chosen from the collection menu. The calculation is typically done within seconds or minutes and the stable URL is provided immediately. The results are presented in both visual (network graphs) and tabular formats using jQuery libraries. Uploaded data and analysis results are kept in separated project directories not accessible by other users. EviNet is available at https://www.evinet.org/.

Reproducible preparation of nanospray tips for capillary electrophoresis coupled to mass spectrometry using 3D printed grinding device.

PubMed

Tycova, Anna; Prikryl, Jan; Foret, Frantisek

2016-04-01

The use of high quality fused silica capillary nanospray tips is critical for obtaining reliable and reproducible electrospray/MS data; however, reproducible laboratory preparation of such tips is a challenging task. In this work, we report on the design and construction of low-cost grinding device assembled from 3D printed and commercially easily available components. Detailed description and characterization of the grinding device is complemented by freely accessible files in stl and skp format allowing easy laboratory replication of the device. The process of sharpening is aimed at achieving maximal symmetricity, surface smoothness and repeatability of the conus shape. Moreover, the presented grinding device brings possibility to fabricate the nanospray tips of desired dimensions regardless of the commercial availability. On several samples of biological nature (reserpine, rabbit plasma, and the mixture of three aminoacids), performance of fabricated tips is shown on CE coupled to MS analysis. The special interest is paid to the effect of tip sharpness. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Electroless plating of ultrathin palladium films: self-initiated deposition and application in microreactor fabrication

NASA Astrophysics Data System (ADS)

Muench, Falk; Oezaslan, Mehtap; Svoboda, Ingrid; Ensinger, Wolfgang

2015-10-01

We present new electroless palladium plating reactions, which can be applied to complex-shaped substrates and lead to homogeneous, dense and conformal palladium films consisting of small nanoparticles. Notably, autocatalytic and surface-selective metal deposition could be achieved on a wide range of materials without sensitization and activation pretreatments. This provides a facile and competitive route to directly deposit well-defined palladium nanofilms on e.g. carbon, paper, polymers or glass substrates. The reactions proceed at mild conditions and are based on easily accessible chemicals (reducing agent: hydrazine; metal source: PdCl2; ligands: ethylenediaminetetraacetic acid (EDTA), acetylacetone). Additionally, the water-soluble capping agent 4-dimethylaminopyridine (DMAP) is employed to increase the bath stability, to ensure the formation of small particles and to improve the film conformity. The great potential of the outlined reactions for micro- and nanofabrication is demonstrated by coating an ion-track etched polycarbonate membrane with a uniform Pd film of approximately 20 nm thickness. The as-prepared membrane is then employed as a highly miniaturized flow reactor, using the reduction of 4-nitrophenol with NaBH4 as a model reaction.

Aspen pectate lyase PtxtPL1-27 mobilizes matrix polysaccharides from woody tissues and improves saccharification yield

PubMed Central

2014-01-01

Background Wood cell walls are rich in cellulose, hemicellulose and lignin. Hence, they are important sources of renewable biomass for producing energy and green chemicals. However, extracting desired constituents from wood efficiently poses significant challenges because these polymers are highly cross-linked in cell walls and are not easily accessible to enzymes and chemicals. Results We show that aspen pectate lyase PL1-27, which degrades homogalacturonan and is expressed at the onset of secondary wall formation, can increase the solubility of wood matrix polysaccharides. Overexpression of this enzyme in aspen increased solubility of not only pectins but also xylans and other hemicelluloses, indicating that homogalacturonan limits the solubility of major wood cell wall components. Enzymatic saccharification of wood obtained from PL1-27-overexpressing trees gave higher yields of pentoses and hexoses than similar treatment of wood from wild-type trees, even after acid pretreatment. Conclusions Thus, the modification of pectins may constitute an important biotechnological target for improved wood processing despite their low abundance in woody biomass. PMID:24450583

Frequently asked questions about in vivo chlorophyll fluorescence: practical issues.

PubMed

Kalaji, Hazem M; Schansker, Gert; Ladle, Richard J; Goltsev, Vasilij; Bosa, Karolina; Allakhverdiev, Suleyman I; Brestic, Marian; Bussotti, Filippo; Calatayud, Angeles; Dąbrowski, Piotr; Elsheery, Nabil I; Ferroni, Lorenzo; Guidi, Lucia; Hogewoning, Sander W; Jajoo, Anjana; Misra, Amarendra N; Nebauer, Sergio G; Pancaldi, Simonetta; Penella, Consuelo; Poli, DorothyBelle; Pollastrini, Martina; Romanowska-Duda, Zdzislawa B; Rutkowska, Beata; Serôdio, João; Suresh, Kancherla; Szulc, Wiesław; Tambussi, Eduardo; Yanniccari, Marcos; Zivcak, Marek

2014-11-01

The aim of this educational review is to provide practical information on the hardware, methodology, and the hands on application of chlorophyll (Chl) a fluorescence technology. We present the paper in a question and answer format like frequently asked questions. Although nearly all information on the application of Chl a fluorescence can be found in the literature, it is not always easily accessible. This paper is primarily aimed at scientists who have some experience with the application of Chl a fluorescence but are still in the process of discovering what it all means and how it can be used. Topics discussed are (among other things) the kind of information that can be obtained using different fluorescence techniques, the interpretation of Chl a fluorescence signals, specific applications of these techniques, and practical advice on different subjects, such as on the length of dark adaptation before measurement of the Chl a fluorescence transient. The paper also provides the physiological background for some of the applied procedures. It also serves as a source of reference for experienced scientists.

In situ formation of the amino sugars 1-amino-1-deoxy-fructose and 2-amino-2-deoxy-glucose under Maillard reaction conditions in the absence of ammonia.

PubMed

Nashalian, Ossanna; Yaylayan, Varoujan A

2016-04-15

Replacing amino acids with their binary metal complexes during the Maillard reaction can initiate various processes, including the oxidative degradation of their glucose conjugates, generating 1-amino-1-deoxy-fructose and its derivatives. These reactive amino sugars are not easily accessible under Maillard reaction conditions and are only formed in the presence of ammonia. To explore the generality of this observation and to study in particular the ability of fructose to generate glucosamine, the amino acid-metal complexes were heated in aqueous solutions with three aldohexoses and two ketohexoses at 110°C for 2 h and the dry residues were analysed by ESI/qTOF/MS/MS. All the sugars generated relatively intense ions at [M+H](+) 180 (C6H14NO5); those ions originating from ketohexoses exhibited MS/MS fragmentations identical to glucosamine and those originating form aldohexoses showed ions identical to fructosamine. Furthermore, the amino sugars were found to form fructosazine, react with other sugars and undergo dehydration reactions. Copyright © 2015 Elsevier Ltd. All rights reserved.

iPad: Semantic annotation and markup of radiological images.

PubMed

Rubin, Daniel L; Rodriguez, Cesar; Shah, Priyanka; Beaulieu, Chris

2008-11-06

Radiological images contain a wealth of information,such as anatomy and pathology, which is often not explicit and computationally accessible. Information schemes are being developed to describe the semantic content of images, but such schemes can be unwieldy to operationalize because there are few tools to enable users to capture structured information easily as part of the routine research workflow. We have created iPad, an open source tool enabling researchers and clinicians to create semantic annotations on radiological images. iPad hides the complexity of the underlying image annotation information model from users, permitting them to describe images and image regions using a graphical interface that maps their descriptions to structured ontologies semi-automatically. Image annotations are saved in a variety of formats,enabling interoperability among medical records systems, image archives in hospitals, and the Semantic Web. Tools such as iPad can help reduce the burden of collecting structured information from images, and it could ultimately enable researchers and physicians to exploit images on a very large scale and glean the biological and physiological significance of image content.

A geometric approach to identify cavities in particle systems

NASA Astrophysics Data System (ADS)

Voyiatzis, Evangelos; Böhm, Michael C.; Müller-Plathe, Florian

2015-11-01

The implementation of a geometric algorithm to identify cavities in particle systems in an open-source python program is presented. The algorithm makes use of the Delaunay space tessellation. The present python software is based on platform-independent tools, leading to a portable program. Its successful execution provides information concerning the accessible volume fraction of the system, the size and shape of the cavities and the group of atoms forming each of them. The program can be easily incorporated into the LAMMPS software. An advantage of the present algorithm is that no a priori assumption on the cavity shape has to be made. As an example, the cavity size and shape distributions in a polyethylene melt system are presented for three spherical probe particles. This paper serves also as an introductory manual to the script. It summarizes the algorithm, its implementation, the required user-defined parameters as well as the format of the input and output files. Additionally, we demonstrate possible applications of our approach and compare its capability with the ones of well documented cavity size estimators.

The Adversarial Route Analysis Tool: A Web Application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Casson, William H. Jr.

2012-08-02

The Adversarial Route Analysis Tool is a type of Google maps for adversaries. It's a web-based Geospatial application similar to Google Maps. It helps the U.S. government plan operations that predict where an adversary might be. It's easily accessible and maintainble and it's simple to use without much training.

Internet Tools Access Administrative Data at the University of Delaware.

ERIC Educational Resources Information Center

Jacobson, Carl

1995-01-01

At the University of Delaware, World Wide Web tools are used to produce multiplatform administrative applications, including hyperreporting, mixed media, electronic forms, and kiosk services. Web applications are quickly and easily crafted to interact with administrative databases. They are particularly suited to customer outreach efforts,…

Cardiovascular Physiology Teaching: Computer Simulations vs. Animal Demonstrations.

ERIC Educational Resources Information Center

Samsel, Richard W.; And Others

1994-01-01

At the introductory level, the computer provides an effective alternative to using animals for laboratory teaching. Computer software can simulate the operation of multiple organ systems. Advantages of software include alteration of variables that are not easily changed in vivo, repeated interventions, and cost-effective hands-on student access.…

POPcorn: An online resource providing access to distributed and diverse maize project data

USDA-ARS?s Scientific Manuscript database

Maize researchers cannot easily leverage all available genetic and genomic data because the online locations of all resources are not easy to find and individual project websites must be searched independently. In addition, project websites degrade over time and sometimes disappear entirely. We cr...

Supporting Online Learners: Blending High-Tech with High-Touch

ERIC Educational Resources Information Center

Dolan, Sean; Donohue, Chip; Holstrom, Lisa; Pernell, Latonia; Sachdev, Anu

2009-01-01

Effective and easily accessible student support services are essential to the success of adult learners. A student-centered approach is especially important in the design and delivery of online courses, professional certificates, and degree programs for early childhood professionals. A student-first approach is essential for non-traditional adult…

Seeing Is Believing: Using Imagery to Enhance Your Coaching

ERIC Educational Resources Information Center

Finch, Laura M.

2011-01-01

Imagery is a powerful sport psychology tool easily accessible to coaches. These reminders can help coaches improve their athletes' images and performance: (1) Create vivid and controllable images; (2) Use polysensory images and instructional cues, delivered, ideally, in real time; (3) Use internal and external perspectives; (4) Use imagery during…

Template Authoring Environment for the Automatic Generation of Narrative Content

ERIC Educational Resources Information Center

Caropreso, Maria Fernanda; Inkpen, Diana; Keshtkar, Fazel; Khan, Shahzad

2012-01-01

Natural Language Generation (NLG) systems can make data accessible in an easily digestible textual form; but using such systems requires sophisticated linguistic and sometimes even programming knowledge. We have designed and implemented an environment for creating and modifying NLG templates that requires no programming knowledge, and can operate…

Special tool kit aids heavily garmented workers

NASA Technical Reports Server (NTRS)

Holmes, A. E.

1966-01-01

Triangular aluminum tool kit, filled with polyurethane is constructed to receive various tools and hold them in a snug but quick-release fit as an aid to heavily gloved workers. The kit is designed to allow mounting within easily accessable reach and to provide protection of the tools during storage.

DEVELOPMENT OF A SYSTEM FOR AN EDUCATIONAL PRODUCTS INFORMATION EXCHANGE. FINAL REPORT.

ERIC Educational Resources Information Center

KOMOSKI, P. KENNETH

THIS STUDY WAS UNDERTAKEN TO DESIGN AN EASILY ACCESSIBLE NATIONWIDE SYSTEM FOR EXCHANGING DESCRIPTIVE, EVALUATIVE PRODUCT INFORMATION AMONG ALL SECTORS OF THE EDUCATIONAL COMMUNITY ON A COOPERATIVE COST-SHARING BASIS. THE FEASIBILITY OF SUCH A COLLECTION AND EXCHANGE OF DESCRIPTIVE AND EVALUATIVE INFORMATION ABOUT INSTRUCTIONAL MATERIALS SYSTEMS…

Will Online Learning Lower the Price of College?

ERIC Educational Resources Information Center

Casement, William

2013-01-01

Online learning is revolutionizing the way colleges do business. Study via the Internet makes more knowledge more easily obtainable for more students than ever before. Along with expanded access to higher education, many people are optimistic about an accompanying benefit--a lower price tag. Basic economic factors make the prospect appear…

75 FR 63884 - Self-Regulatory Organizations; Municipal Securities Rulemaking Board; Order Approving Proposed...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-18

... unfairly allows institutional and sophisticated investors to more easily access information about a... information directly to EMMA is a more efficient way of disseminating information to investors, noting that... in the level of investor protection provided by the MSRB's information systems and [[Page 63886...

Highlights from Education at a Glance 2010

ERIC Educational Resources Information Center

OECD Publishing (NJ3), 2010

2010-01-01

"Highlights from Education at a Glance 2010" is a companion publication to the OECD's flagship compendium of education statistics, Education at a Glance. It provides easily accessible data on key topics in education today, including: education levels and student numbers, economic and social benefits of education, education spending, the school…

14 CFR 23.783 - Doors.

Code of Federal Regulations, 2010 CFR

2010-01-01

... least one adequate and easily accessible external door. (b) Passenger doors must not be located with...) Each external passenger or crew door must comply with the following requirements: (1) There must be a... the internal locking mechanism is in the locked position. (3) There must be a means of opening which...

Using JournalMap to improve ecological knowledge discovery and visualization

USDA-ARS?s Scientific Manuscript database

Background/Question/Methods Most of the ecological research conducted around the world is tied to specific places, however, that location information is locked up in the text and figures of scientific articles in myriad forms that are not easily searchable. While access to ecological literature ha...

Defining ecohydrological function to support low impact development in coastal South Carolina

Treesearch

Daniel Hitchcock; A.D. Jayakaran; T. H. Epps; J.A. Palazzolo; T.M. Williams; D.M. Amatya

2016-01-01

In the face of dual pressures in coastal South Carolina - residential and commercial development, along with potential climate change impacts - stakeholders need clear, accurate, relevant, and easily-accessible information for effective decision-making for watershed management and natural resource protection.

Does Research Information Meet the Needs of Stakeholders? Exploring Evidence Selection in the Global Management of Invasive Species

ERIC Educational Resources Information Center

Bayliss, Helen R.; Wilcox, Andrew; Stewart, Gavin B.; Randall, Nicola P.

2012-01-01

This study explored factors affecting information selection by international stakeholders working with invasive species. Despite differences in information requirements between groups, all stakeholders demonstrated a clear preference for free, easily accessible online information, and predominantly used internet search engines and specialist…

The Prospects for Security Sector Reform in Tunisia: A Year After the Revolution

DTIC Science & Technology

2012-09-01

included.86 This single, easily accessible, and searchable resource for all laws and amendments pertaining to the secu- rity sector greatly enhances ...Reform of the Peni - tentiary System,” Geneva Centre for the Democratic Control of Armed Forces, DCAF-Tunisie, October 5, 2011, available from dcaf

Developing a healthcare law library.

PubMed

Sconyers, J M

1998-01-01

Legal materials are expensive, bulky, and extremely time sensitive. Selecting the appropriate means of ensuring easy access to easily-retrievable, timely legal materials is of extreme importance to any lawyer. The author gives an overview of the various means of retrieving necessary research, including the strengths and weaknesses of each of the various options.

Occupational Choice Strategy: A Small Group Vocational Counseling Program. Participant's Workbook.

ERIC Educational Resources Information Center

Schriner, Kay Fletcher; Roessler, Richard T.

The student workbook is part of the Occupational Choice Strategy (OCS) small group vocational counseling program. OCS incorporates: (1) concise occupational information easily accessed by the participants, (2) assessment methods that clarify a client's self-picture and vocational potential, (3) opportunities to practice decision-making and…

Data-Driven Decision Making in Practice: The NCAA Injury Surveillance System

ERIC Educational Resources Information Center

Klossner, David; Corlette, Jill; Agel, Julie; Marshall, Stephen W.

2009-01-01

Putting data-driven decision making into practice requires the use of consistent and reliable data that are easily accessible. The systematic collection and maintenance of accurate information is an important component in developing policy and evaluating outcomes. Since 1982, the National Collegiate Athletic Association (NCAA) has been collecting…

Using a Local Greenway to Study the River Environment and Urban Landscape

ERIC Educational Resources Information Center

Lackstrom, Kirsten; Stroup, Laura J.

2009-01-01

Greenways are prominent features of many urban landscapes and synthesize several geographic topics: human-environment interactions, urban ecosystems, and the promotion of sustainability within riverine corridors. Greenways are easily accessible and provide an opportunity for students at various grade levels to study interactions across physical…

Using Creative Writing to Teach Exposition/Artistic/Report Writing.

ERIC Educational Resources Information Center

West, William W.

Teachers who restrict their teaching of writing to elements of exposition are likely to fail because there is insufficient content, interest, or challenge in learning simple exposition, and the techniques that contribute to polished exposition are more easily accessible when approached through aesthetic writing. A teaching sequence for using…

Two Libraries Working toward Common Goals

ERIC Educational Resources Information Center

Potter, Tonya; Johnson, Kara

2017-01-01

Students look to their school library to find new books, seek information, creatively solve problems, and use technology. School libraries play an essential role in students' academic growth and development of lifelong learning skills. All of the wonderful resources and services that school libraries provide are easily accessible to the population…

The Black Belt Librarian: Real-World Safety & Security

ERIC Educational Resources Information Center

Graham, Warren

2012-01-01

Sharing expertise gleaned from more than two decades as a library security manager, Graham demonstrates that libraries can maintain their best traditions of openness and public access by creating an unobtrusive yet effective security plan. In straightforward language, the author: (1) Shows how to easily set clear expectations for visitors'…

Using a Virtual Population to Authentically Teach Epidemiology and Biostatistics

ERIC Educational Resources Information Center

Dunn, Peter K.; Donnison, Sharn; Cole, Rachel; Bulmer, Michael

2017-01-01

Epidemiology is the study of the distribution of disease in human populations. This means that authentically teaching primary data collection in epidemiology is difficult as students cannot easily access suitable human populations. Using an action research methodology, this paper studied the use of a virtual human population (called "The…

The Language of Chemistry.

ERIC Educational Resources Information Center

Bretz, Stacey Lowery; Meinwald, Jerrold

2002-01-01

Describes a new curriculum called The Language of Chemistry designed to illustrate how problems of biological and/or medical importance can be understood on a molecular basis and to show that the logic, knowledge, and language needed are easily accessible. Among the case studies in the curriculum are the giant peacock moth, bacterial chemotaxis,…

Intelligent resource discovery using ontology-based resource profiles

NASA Technical Reports Server (NTRS)

Hughes, J. Steven; Crichton, Dan; Kelly, Sean; Crichton, Jerry; Tran, Thuy

2004-01-01

Successful resource discovery across heterogeneous repositories is strongly dependent on the semantic and syntactic homogeneity of the associated resource descriptions. Ideally, resource descriptions are easily extracted from pre-existing standardized sources, expressed using standard syntactic and semantic structures, and managed and accessed within a distributed, flexible, and scaleable software framework.

77 FR 31438 - Agency Information Collection Activities: Proposed Information Collection; Submission for OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

... institution regulated by the FCA (Agency-regulated institutions) who engages in the business of a residential... easily accessible information at no charge regarding the employment history of, and the publicly... (2) personal history and experience, including authorization for the Registry to obtain information...

Determination of Plant Volatiles Using Solid Phase Microextraction GC-MS

ERIC Educational Resources Information Center

Van Bramer, Scott; Goodrich, Katherine R.

2015-01-01

This experiment combines analytical techniques of solid phase microextraction and gas chromatography-mass spectrometry with easily relatable and accessible plant volatile chemistry (floral and vegetative scents of local/available plants). The biosynthesis and structure of these chemicals are of interest in the areas of organic chemistry,…

Using JournalMap to improve discovery and visualization of rangeland scientific knowledge

USDA-ARS?s Scientific Manuscript database

Most of the ecological research conducted around the world is tied to specific places; however, that location information is locked up in the text and figures of scientific articles in myriad forms that are not easily searchable. While access to ecological literature has improved dramatically in the...

Teaching World History with "Things Fall Apart."

ERIC Educational Resources Information Center

Feldmann, Martha J.

1995-01-01

Recommends using Chinua Achebe's novel of the 19th-century conflict between African tribal culture and English colonists in a world history class. Achebe's rich narrative, written in a graceful prose, is easily accessible to high school students. The novel replaces simplistic and abstract concepts with those more complex and concrete. (MJP)

Dollars for Dreams: Student Affairs Staff as Fundraisers.

ERIC Educational Resources Information Center

Penney, Sophie W.; Rose, Barbara B.

This publication provides an educational tool for student affairs professionals involved in fundraising. It is designed to be easily accessible and understood by those with little experience with fundraising, and it will also serve as a useful resource for student affairs professionals who have partnered with fundraisers to, or who themselves…

30 CFR 36.31 - Fire extinguisher.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Fire extinguisher. 36.31 Section 36.31 Mineral... Construction and Design Requirements § 36.31 Fire extinguisher. Each unit of mobile diesel-powered transportation equipment shall be fitted with a fire extinguisher carried in a location easily accessible to the...

A novel glass slide filing system for pathology slides.

PubMed

Tsai, Steve; Kartono, Francisca; Shitabata, Paul K

2007-07-01

The availability of a collection of microscope glass slides for review is essential in the study and practice of pathology. A common problem facing many pathologists is the lack of a well-organized filing system. We present a novel system that would be easily accessible, informative, protective, and portable.

Why Cash Flow Is No Longer for Wimps

ERIC Educational Resources Information Center

Curry, John R.; Hutton, Lyn

2012-01-01

Managing liquidity--a college or university's ability to access cash quickly or to easily convert assets to cash--is an increasingly crucial component of enterprise risk management. Liquidity risks lurk around nearly every corner--in the endowment portfolio, the debt portfolio, and in working-capital management. It also influences students'…

The Push for Public Preschool

ERIC Educational Resources Information Center

Dessoff, Alan

2010-01-01

From selecting appropriate curricula and teachers to providing classrooms with bathrooms easily accessible to 4-year-olds, public preschool programs present challenges to districts that run the programs, which are designed to prepare children to get off to a good start when they enter kindergarten. While a wide range of private preschool programs…

One Bottleneck at a Time

ERIC Educational Resources Information Center

Bonner, J. Jose; Lotter, Christine; Harwood, William

2004-01-01

Teachers can easily identify what subjects their students have trouble with, whether it is transcription and translation, glycolysis and fermentation, balancing chemical equations, or vector analysis of forces acting on an object. Yet, no matter how teachers try to make these complex issues more accessible to students, or how new editions of…

14 CFR 23.783 - Doors.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Doors. 23.783 Section 23.783 Aeronautics... Cargo Accommodations § 23.783 Doors. (a) Each closed cabin with passenger accommodations must have at least one adequate and easily accessible external door. (b) Passenger doors must not be located with...

Visualising "Junk" DNA through Bioinformatics

ERIC Educational Resources Information Center

Elwess, Nancy L.; Latourelle, Sandra M.; Cauthorn, Olivia

2005-01-01

One of the hottest areas of science today is the field in which biology, information technology,and computer science are merged into a single discipline called bioinformatics. This field enables the discovery and analysis of biological data, including nucleotide and amino acid sequences that are easily accessed through the use of computers. As…

Assessment and Assurance of Learning Using E-Portfolios

ERIC Educational Resources Information Center

Papp, Raymond

2014-01-01

Traditional paper portfolios have been used to assess student work for performance and employment purposes for decades. The advent of electronic portfolios incorporating audio, video, hyperlinked documents and scanned images takes the use of portfolios to a new level. Evaluators can use these easily accessible portfolios to gauge student…

New Tools to Search for Data in the European Space Agency's Planetary Science Archive

NASA Astrophysics Data System (ADS)

Grotheer, E.; Macfarlane, A. J.; Rios, C.; Arviset, C.; Heather, D.; Fraga, D.; Vallejo, F.; De Marchi, G.; Barbarisi, I.; Saiz, J.; Barthelemy, M.; Docasal, R.; Martinez, S.; Besse, S.; Lim, T.

2016-12-01

The European Space Agency's (ESA) Planetary Science Archive (PSA), which can be accessed at http://archives.esac.esa.int/psa, provides public access to the archived data of Europe's missions to our neighboring planets. These datasets are compliant with the Planetary Data System (PDS) standards. Recently, a new interface has been released, which includes upgrades to make PDS4 data available from newer missions such as ExoMars and BepiColombo. Additionally, the PSA development team has been working to ensure that the legacy PDS3 data will be more easily accessible via the new interface as well. In addition to a new querying interface, the new PSA also allows access via the EPN-TAP and PDAP protocols. This makes the PSA data sets compatible with other archive-related tools and projects, such as the Virtual European Solar and Planetary Access (VESPA) project for creating a virtual observatory.

Easy access to heterobimetallic complexes for medical imaging applications via microwave-enhanced cycloaddition.

PubMed

Desbois, Nicolas; Pacquelet, Sandrine; Dubois, Adrien; Michelin, Clément; Gros, Claude P

2015-01-01

The Cu(I)-catalysed Huisgen cycloaddition, known as "click" reaction, has been applied to the synthesis of a range of triazole-linked porphyrin/corrole to DOTA/NOTA derivatives. Microwave irradiation significantly accelerates the reaction. The synthesis of heterobimetallic complexes was easily achieved in up to 60% isolated yield. Heterobimetallic complexes were easily prepared as potential MRI/PET (SPECT) bimodal contrast agents incorporating one metal (Mn, Gd) for the enhancement of contrast for MRI applications and one "cold" metal (Cu, Ga, In) for future radionuclear imaging applications. Preliminary relaxivity measurements showed that the reported complexes are promising contrast agents (CA) in MRI.

The iPlant Collaborative: Cyberinfrastructure for Enabling Data to Discovery for the Life Sciences.

PubMed

Merchant, Nirav; Lyons, Eric; Goff, Stephen; Vaughn, Matthew; Ware, Doreen; Micklos, David; Antin, Parker

2016-01-01

The iPlant Collaborative provides life science research communities access to comprehensive, scalable, and cohesive computational infrastructure for data management; identity management; collaboration tools; and cloud, high-performance, high-throughput computing. iPlant provides training, learning material, and best practice resources to help all researchers make the best use of their data, expand their computational skill set, and effectively manage their data and computation when working as distributed teams. iPlant's platform permits researchers to easily deposit and share their data and deploy new computational tools and analysis workflows, allowing the broader community to easily use and reuse those data and computational analyses.

Easy access to heterobimetallic complexes for medical imaging applications via microwave-enhanced cycloaddition

PubMed Central

Desbois, Nicolas; Pacquelet, Sandrine; Dubois, Adrien; Michelin, Clément

2015-01-01

Summary The Cu(I)-catalysed Huisgen cycloaddition, known as “click” reaction, has been applied to the synthesis of a range of triazole-linked porphyrin/corrole to DOTA/NOTA derivatives. Microwave irradiation significantly accelerates the reaction. The synthesis of heterobimetallic complexes was easily achieved in up to 60% isolated yield. Heterobimetallic complexes were easily prepared as potential MRI/PET (SPECT) bimodal contrast agents incorporating one metal (Mn, Gd) for the enhancement of contrast for MRI applications and one “cold” metal (Cu, Ga, In) for future radionuclear imaging applications. Preliminary relaxivity measurements showed that the reported complexes are promising contrast agents (CA) in MRI. PMID:26664643

[Antegrade catheterization of the brachial artery during treatment of arteriovenous angiodysplasia of the forearm and hand].

PubMed

Tsygankov, V N; Varava, A B

2013-01-01

The authors share herein their experience with an antegrade brachial access for treatment of patients presenting with arteriovenous angiodysplasia localizing on the distal portions of the upper limbs, also describing the choice of the site for puncture and the technique of antegrade catheterization of the brachial artery. This is followed by reporting the results of successful use of this access in a total of 27 patients. The access is simple to create, making it possible to easily perform the intervention using instruments of standard length. It is also safe, requires no bed rest in the postoperative period, and is well tolerated by the patients.

The hospital library and the enterprise portal.

PubMed

Bandy, Margaret; Fosmire, Brenda

2004-01-01

At Exempla Healthcare, the medical librarians and the e-Business staff are creating an enterprise information portal where medical reference is targeted, easily accessible, and supported by the medical librarians. A team approach has been essential. The e-Business department has worked for nine months coordinating technical challenges required to support personalization, targeted communications, and a single access point for clinical patient data. Exempla medical librarians have been involved in the definition and design of information access needs from the very beginning. The Clinicians Portal was the first developed, with other customizations to follow. Many challenges remain, but by definition, a portal is designed to be flexible and adapt to the changing needs of the enterprise it supports.

Investigation of the Profile Control Mechanisms of Dispersed Particle Gel

PubMed Central

Zhao, Guang; Dai, Caili; Zhao, Mingwei

2014-01-01

Dispersed particle gel (DPG) particles of nano- to micron- to mm-size have been prepared successfully and will be used for profile control treatment in mature oilfields. The profile control and enhanced oil recovery mechanisms of DPG particles have been investigated using core flow tests and visual simulation experiments. Core flow test results show that DPG particles can easily be injected into deep formations and can effectively plug the high permeability zones. The high profile improvement rate improves reservoir heterogeneity and diverts fluid into the low permeability zone. Both water and oil permeability were reduced when DPG particles were injected, but the disproportionate permeability reduction effect was significant. Water permeability decreases more than the oil permeability to ensure that oil flows in its own pathways and can easily be driven out. Visual simulation experiments demonstrate that DPG particles can pass directly or by deformation through porous media and enter deep formations. By retention, adsorption, trapping and bridging, DPG particles can effectively reduce the permeability of porous media in high permeability zones and divert fluid into a low permeability zone, thus improving formation profiles and enhancing oil recovery. PMID:24950174

Electronic Procedures for Medical Operations

NASA Technical Reports Server (NTRS)

2015-01-01

Electronic procedures are replacing text-based documents for recording the steps in performing medical operations aboard the International Space Station. S&K Aerospace, LLC, has developed a content-based electronic system-based on the Extensible Markup Language (XML) standard-that separates text from formatting standards and tags items contained in procedures so they can be recognized by other electronic systems. For example, to change a standard format, electronic procedures are changed in a single batch process, and the entire body of procedures will have the new format. Procedures can be quickly searched to determine which are affected by software and hardware changes. Similarly, procedures are easily shared with other electronic systems. The system also enables real-time data capture and automatic bookmarking of current procedure steps. In Phase II of the project, S&K Aerospace developed a Procedure Representation Language (PRL) and tools to support the creation and maintenance of electronic procedures for medical operations. The goal is to develop these tools in such a way that new advances can be inserted easily, leading to an eventual medical decision support system.

76 FR 26983 - Improving Wireless Coverage Through the Use of Signal Boosters

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-10

... Disabilities: To request materials in accessible formats for people with disabilities (braille, large [email protected] . 5. To request materials in accessible formats for people with disabilities (Braille, large... signal boosters. Specifically, the Commission proposes that marketing materials must include a...

Development of an expert analysis tool based on an interactive subsidence hazard map for urban land use in the city of Celaya, Mexico

NASA Astrophysics Data System (ADS)

Alloy, A.; Gonzalez Dominguez, F.; Nila Fonseca, A. L.; Ruangsirikulchai, A.; Gentle, J. N., Jr.; Cabral, E.; Pierce, S. A.

2016-12-01

Land Subsidence as a result of groundwater extraction in central Mexico's larger urban centers initiated in the 80's as a result of population and economic growth. The city of Celaya has undergone subsidence for a few decades and a consequence is the development of an active normal fault system that affects its urban infrastructure and residential areas. To facilitate its analysis and a land use decision-making process we created an online interactive map enabling users to easily obtain information associated with land subsidence. Geological and socioeconomic data of the city was collected, including fault location, population data, and other important infrastructure and structural data has been obtained from fieldwork as part of a study abroad interchange undergraduate course. The subsidence and associated faulting hazard map was created using an InSAR derived subsidence velocity map and population data from INEGI to identify hazard zones using a subsidence gradient spatial analysis approach based on a subsidence gradient and population risk matrix. This interactive map provides a simple perspective of different vulnerable urban elements. As an accessible visualization tool, it will enhance communication between scientific and socio-economic disciplines. Our project also lays the groundwork for a future expert analysis system with an open source and easily accessible Python coded, SQLite database driven website which archives fault and subsidence data along with visual damage documentation to civil structures. This database takes field notes and provides an entry form for uniform datasets, which are used to generate a JSON. Such a database is useful because it allows geoscientists to have a centralized repository and access to their observations over time. Because of the widespread presence of the subsidence phenomena throughout cities in central Mexico, the spatial analysis has been automated using the open source software R. Raster, rgeos, shapefiles, and rgdal libraries have been used to develop the script which permits to obtain the raster maps of horizontal gradient and population density. An advantage is that this analysis can be automated for periodic updates or repurposed for similar analysis in other cities, providing an easily accessible tool for land subsidence hazard assessments.

The Second Annual Space Weather Community Operations Workshop: Advancing Operations Into the Next Decade

NASA Astrophysics Data System (ADS)

Meehan, Jennifer; Fulgham, Jared; Tobiska, W. Kent

2012-07-01

How can we continue to advance the space weather operational community from lessons already learned when it comes to data reliability, maintainability, accessibility, dependability, safety, and quality? How can we make space weather more easily accessible to each other and outside users? Representatives from operational, commercial, academic, and government organizations weighed in on these important questions at the second annual Space Weather Community Operations Workshop, held 22-23 March 2012 in Park City, Utah, with the unofficial workshop motto being Don’t Reinvent the Wheel.

Development of continuing nursing education offerings for the World Wide Web.

PubMed

Billings, D M; Rowles, C J

2001-01-01

Nurses are seeking continuing professional development that is easily accessible, convenient, and available at any time and any place. As nurses have increasing access to Internets and Intranets at home and their workplace, courses for continuing nursing education must be available to meet this need. This article discusses the planning, implementation, and evaluation of continuing nursing education (CNE) on the World Wide Web. The article explains how to develop a strategic plan, develop course offerings, select technology tools to support teaching and learning, and market and evaluate the courses.

Current Approaches to Improving Marine Geophysical Data Discovery and Access

NASA Astrophysics Data System (ADS)

Jencks, J. H.; Cartwright, J.; Varner, J. D.; Anderson, C.; Robertson, E.; McLean, S. J.

2016-02-01

Exploring, understanding, and managing the global oceans is a challenge when hydrographic maps are available for only 5% of the world's oceans, even less of which have been mapped geologically or to identify benthic habitats. Seafloor mapping is expensive and most government and academic budgets continue to tighten. The first step for any mapping program, before setting out to map uncharted waters, should be to identify if data currently exist in the area of interest. There are many reasons why this seemingly simple suggestion is not commonplace. While certain datasets are accessible online (e.g., NOAA's NCEI, EMODnet, IHO-DCDB), many are not. In some cases, data that are publicly available are difficult to discover and access. No single agency can successfully resolve the complex and pressing demands of ocean and coastal mapping and the associated data stewardship. NOAA partners with other federal agencies to provide an integrated approach to carry out a coordinated and comprehensive ocean and coastal mapping program. In order to maximize the return on their mapping investment, legacy and newly acquired data must be easily discoverable and readily accessible by numerous applications and formats now and well into the future. At NOAA's National Centers for Environmental Information (NCEI), resources are focused on ensuring the security and widespread availability of the Nation's scientific marine geophysical data through long-term stewardship. The public value of these data and products is maximized by streamlining data acquisition and processing operations, minimizing redundancies, facilitating discovery, and developing common standards to promote re-use. For its part, NCEI draws on a variety of software technologies and adheres to international standards to meet this challenge. The result is a geospatial framework built on spatially-enabled databases, standards-based web services, and International Standards Organization (ISO) metadata. In order to maximize effectiveness in ocean and coastal mapping, we must be sure that limited funding is not being used to collect data in areas where data already exist. By making data more accessible, NCEI extends the use of, and therefore the value of, these data. Working together, we can ensure that valuable data are made available to the broadest community.

An Information System for European culture collections: the way forward.

PubMed

Casaregola, Serge; Vasilenko, Alexander; Romano, Paolo; Robert, Vincent; Ozerskaya, Svetlana; Kopf, Anna; Glöckner, Frank O; Smith, David

2016-01-01

Culture collections contain indispensable information about the microorganisms preserved in their repositories, such as taxonomical descriptions, origins, physiological and biochemical characteristics, bibliographic references, etc. However, information currently accessible in databases rarely adheres to common standard protocols. The resultant heterogeneity between culture collections, in terms of both content and format, notably hampers microorganism-based research and development (R&D). The optimized exploitation of these resources thus requires standardized, and simplified, access to the associated information. To this end, and in the interest of supporting R&D in the fields of agriculture, health and biotechnology, a pan-European distributed research infrastructure, MIRRI, including over 40 public culture collections and research institutes from 19 European countries, was established. A prime objective of MIRRI is to unite and provide universal access to the fragmented, and untapped, resources, information and expertise available in European public collections of microorganisms; a key component of which is to develop a dynamic Information System. For the first time, both culture collection curators as well as their users have been consulted and their feedback, concerning the needs and requirements for collection databases and data accessibility, utilised. Users primarily noted that databases were not interoperable, thus rendering a global search of multiple databases impossible. Unreliable or out-of-date and, in particular, non-homogenous, taxonomic information was also considered to be a major obstacle to searching microbial data efficiently. Moreover, complex searches are rarely possible in online databases thus limiting the extent of search queries. Curators also consider that overall harmonization-including Standard Operating Procedures, data structure, and software tools-is necessary to facilitate their work and to make high-quality data easily accessible to their users. Clearly, the needs of culture collection curators coincide with those of users on the crucial point of database interoperability. In this regard, and in order to design an appropriate Information System, important aspects on which the culture collection community should focus include: the interoperability of data sets with the ontologies to be used; setting best practice in data management, and the definition of an appropriate data standard.

Oceans of Data: In what ways can learning research inform the development of electronic interfaces and tools for use by students accessing large scientific databases?

NASA Astrophysics Data System (ADS)

Krumhansl, R. A.; Foster, J.; Peach, C. L.; Busey, A.; Baker, I.

2012-12-01

The practice of science and engineering is being revolutionized by the development of cyberinfrastructure for accessing near real-time and archived observatory data. Large cyberinfrastructure projects have the potential to transform the way science is taught in high school classrooms, making enormous quantities of scientific data available, giving students opportunities to analyze and draw conclusions from many kinds of complex data, and providing students with experiences using state-of-the-art resources and techniques for scientific investigations. However, online interfaces to scientific data are built by scientists for scientists, and their design can significantly impede broad use by novices. Knowledge relevant to the design of student interfaces to complex scientific databases is broadly dispersed among disciplines ranging from cognitive science to computer science and cartography and is not easily accessible to designers of educational interfaces. To inform efforts at bridging scientific cyberinfrastructure to the high school classroom, Education Development Center, Inc. and the Scripps Institution of Oceanography conducted an NSF-funded 2-year interdisciplinary review of literature and expert opinion pertinent to making interfaces to large scientific databases accessible to and usable by precollege learners and their teachers. Project findings are grounded in the fundamentals of Cognitive Load Theory, Visual Perception, Schemata formation and Universal Design for Learning. The Knowledge Status Report (KSR) presents cross-cutting and visualization-specific guidelines that highlight how interface design features can address/ ameliorate challenges novice high school students face as they navigate complex databases to find data, and construct and look for patterns in maps, graphs, animations and other data visualizations. The guidelines present ways to make scientific databases more broadly accessible by: 1) adjusting the cognitive load imposed by the user interface and visualizations so that it doesn't exceed the amount of information the learner can actively process; 2) drawing attention to important features and patterns; and 3) enabling customization of visualizations and tools to meet the needs of diverse learners.

YummyData: providing high-quality open life science data

PubMed Central

Yamaguchi, Atsuko; Splendiani, Andrea

2018-01-01

Abstract Many life science datasets are now available via Linked Data technologies, meaning that they are represented in a common format (the Resource Description Framework), and are accessible via standard APIs (SPARQL endpoints). While this is an important step toward developing an interoperable bioinformatics data landscape, it also creates a new set of obstacles, as it is often difficult for researchers to find the datasets they need. Different providers frequently offer the same datasets, with different levels of support: as well as having more or less up-to-date data, some providers add metadata to describe the content, structures, and ontologies of the stored datasets while others do not. We currently lack a place where researchers can go to easily assess datasets from different providers in terms of metrics such as service stability or metadata richness. We also lack a space for collecting feedback and improving data providers’ awareness of user needs. To address this issue, we have developed YummyData, which consists of two components. One periodically polls a curated list of SPARQL endpoints, monitoring the states of their Linked Data implementations and content. The other presents the information measured for the endpoints and provides a forum for discussion and feedback. YummyData is designed to improve the findability and reusability of life science datasets provided as Linked Data and to foster its adoption. It is freely accessible at http://yummydata.org/. Database URL: http://yummydata.org/ PMID:29688370

Harmonize Pipeline and Archiving Aystem: PESSTO@IA2 Use Case

NASA Astrophysics Data System (ADS)

Smareglia, R.; Knapic, C.; Molinaro, M.; Young, D.; Valenti, S.

2013-10-01

Italian Astronomical Archives Center (IA2) is a research infrastructure project that aims at coordinating different national and international initiatives to improve the quality of astrophysical data services. IA2 is now also involved in the PESSTO (Public ESO Spectroscopic Survey of Transient Objects) collaboration, developing a complete archiving system to store calibrated post processed data (including sensitive intermediate products), a user interface to access private data and Virtual Observatory (VO) compliant web services to access public fast reduction data via VO tools. The archive system shall rely on the PESSTO Marshall to provide file data and its associated metadata output by the PESSTO data-reduction pipeline. To harmonize the object repository, data handling and archiving system, new tools are under development. These systems must have a strong cross-interaction without increasing the complexities of any single task, in order to improve the performances of the whole system and must have a sturdy logic in order to perform all operations in coordination with the other PESSTO tools. MySQL Replication technology and triggers are used for the synchronization of new data in an efficient, fault tolerant manner. A general purpose library is under development to manage data starting from raw observations to final calibrated ones, open to the overriding of different sources, formats, management fields, storage and publication policies. Configurations for all the systems are stored in a dedicated schema (no configuration files), but can be easily updated by a planned Archiving System Configuration Interface (ASCI).

MOSAIC: an online database dedicated to the comparative genomics of bacterial strains at the intra-species level.

PubMed

Chiapello, Hélène; Gendrault, Annie; Caron, Christophe; Blum, Jérome; Petit, Marie-Agnès; El Karoui, Meriem

2008-11-27

The recent availability of complete sequences for numerous closely related bacterial genomes opens up new challenges in comparative genomics. Several methods have been developed to align complete genomes at the nucleotide level but their use and the biological interpretation of results are not straightforward. It is therefore necessary to develop new resources to access, analyze, and visualize genome comparisons. Here we present recent developments on MOSAIC, a generalist comparative bacterial genome database. This database provides the bacteriologist community with easy access to comparisons of complete bacterial genomes at the intra-species level. The strategy we developed for comparison allows us to define two types of regions in bacterial genomes: backbone segments (i.e., regions conserved in all compared strains) and variable segments (i.e., regions that are either specific to or variable in one of the aligned genomes). Definition of these segments at the nucleotide level allows precise comparative and evolutionary analyses of both coding and non-coding regions of bacterial genomes. Such work is easily performed using the MOSAIC Web interface, which allows browsing and graphical visualization of genome comparisons. The MOSAIC database now includes 493 pairwise comparisons and 35 multiple maximal comparisons representing 78 bacterial species. Genome conserved regions (backbones) and variable segments are presented in various formats for further analysis. A graphical interface allows visualization of aligned genomes and functional annotations. The MOSAIC database is available online at http://genome.jouy.inra.fr/mosaic.

pvsR: An Open Source Interface to Big Data on the American Political Sphere

PubMed Central

2015-01-01

Digital data from the political sphere is abundant, omnipresent, and more and more directly accessible through the Internet. Project Vote Smart (PVS) is a prominent example of this big public data and covers various aspects of U.S. politics in astonishing detail. Despite the vast potential of PVS’ data for political science, economics, and sociology, it is hardly used in empirical research. The systematic compilation of semi-structured data can be complicated and time consuming as the data format is not designed for conventional scientific research. This paper presents a new tool that makes the data easily accessible to a broad scientific community. We provide the software called pvsR as an add-on to the R programming environment for statistical computing. This open source interface (OSI) serves as a direct link between a statistical analysis and the large PVS database. The free and open code is expected to substantially reduce the cost of research with PVS’ new big public data in a vast variety of possible applications. We discuss its advantages vis-à-vis traditional methods of data generation as well as already existing interfaces. The validity of the library is documented based on an illustration involving female representation in local politics. In addition, pvsR facilitates the replication of research with PVS data at low costs, including the pre-processing of data. Similar OSIs are recommended for other big public databases. PMID:26132154

DamaGIS: a multisource geodatabase for collection of flood-related damage data

NASA Astrophysics Data System (ADS)

Saint-Martin, Clotilde; Javelle, Pierre; Vinet, Freddy

2018-06-01

Every year in France, recurring flood events result in several million euros of damage, and reducing the heavy consequences of floods has become a high priority. However, actions to reduce the impact of floods are often hindered by the lack of damage data on past flood events. The present paper introduces a new database for collection and assessment of flood-related damage. The DamaGIS database offers an innovative bottom-up approach to gather and identify damage data from multiple sources, including new media. The study area has been defined as the south of France considering the high frequency of floods over the past years. This paper presents the structure and contents of the database. It also presents operating instructions in order to keep collecting damage data within the database. This paper also describes an easily reproducible method to assess the severity of flood damage regardless of the location or date of occurrence. A first analysis of the damage contents is also provided in order to assess data quality and the relevance of the database. According to this analysis, despite its lack of comprehensiveness, the DamaGIS database presents many advantages. Indeed, DamaGIS provides a high accuracy of data as well as simplicity of use. It also has the additional benefit of being accessible in multiple formats and is open access. The DamaGIS database is available at https://doi.org/10.5281/zenodo.1241089.

Thermodynamic Equilibrium Calculations on Cd Transformation during Sewage Sludge Incineration.

PubMed

Liu, Jing-yong; Huang, Limao; Sun, Shuiyu; Ning, Xun'an; Kuo, Jiahong; Sun, Jian; Wang, Yujie; Xie, Wuming

2016-06-01

Thermodynamic equilibrium calculations were performed to reveal the distribution of cadmium during the sewage sludge incineration process. During sludge incineration in the presence of major minerals, such as SiO2, Al2O3 and CaO, the strongest effect was exerted by SiO2 on the Cd transformation compared with the effect of others. The stable solid product of CdSiO3 was formed easily with the reaction between Cd and SiO2, which can restrain the emissions of gaseous Cd pollutants. CdCl2 was formed more easily in the presence of chloride during incineration, thus, the volatilization of Cd was advanced by increasing chlorine content. At low temperatures, the volatilization of Cd was restrained due to the formation of the refractory solid metal sulfate. At high temperatures, the speciation of Cd was not affected by the presence of sulfur, but sulfur could affect the formation temperature of gaseous metals.

GANDALF - Graphical Astrophysics code for N-body Dynamics And Lagrangian Fluids

NASA Astrophysics Data System (ADS)

Hubber, D. A.; Rosotti, G. P.; Booth, R. A.

2018-01-01

GANDALF is a new hydrodynamics and N-body dynamics code designed for investigating planet formation, star formation and star cluster problems. GANDALF is written in C++, parallelized with both OPENMP and MPI and contains a PYTHON library for analysis and visualization. The code has been written with a fully object-oriented approach to easily allow user-defined implementations of physics modules or other algorithms. The code currently contains implementations of smoothed particle hydrodynamics, meshless finite-volume and collisional N-body schemes, but can easily be adapted to include additional particle schemes. We present in this paper the details of its implementation, results from the test suite, serial and parallel performance results and discuss the planned future development. The code is freely available as an open source project on the code-hosting website github at https://github.com/gandalfcode/gandalf and is available under the GPLv2 license.

An easy and effective approach to manage radiologic portable document format (PDF) files using iTunes.

PubMed

Qian, Li Jun; Zhou, Mi; Xu, Jian Rong

2008-07-01

The objective of this article is to explain an easy and effective approach for managing radiologic files in portable document format (PDF) using iTunes. PDF files are widely used as a standard file format for electronic publications as well as for medical online documents. Unfortunately, there is a lack of powerful software to manage numerous PDF documents. In this article, we explain how to use the hidden function of iTunes (Apple Computer) to manage PDF documents as easily as managing music files.

Formation and dispersion of mycelial pellets of Streptomyces coelicolor A3(2).

PubMed

Kim, Yul-Min; Kim, Jae-heon

2004-03-01

The pellets from a culture of Streptomyces coelicolor A3(2) that were submerged shaken were disintegrated into numerous hyphal fragments by DNase treatment. The pellets were increasingly dispersed by hyaluronidase treatment, and mycelial fragments were easily detached from the pellets. The submerged mycelium grew by forming complexes with calcium phosphate precipitates or kaolin, a soil particle. Therefore, the pellet formation of Streptomyces coelicolor A3(2) can be considered a biofilm formation, including the participation of adhesive extracellular polymers and the insoluble substrates.

Mobile learning to improve mathematics teachers mathematical competencies

NASA Astrophysics Data System (ADS)

Hendrayana, A.; Wahyudin

2018-01-01

The role of teachers is crucial to the success of mathematics learning. One of the learning indicator is characterized by the students’ improved mathematical proficiency. In order to increase that, it is necessary to improve the teacher’s mathematical skills first. For that, it needs an innovative way to get teachers close to easily accessible learning resources through technology. The technology can facilitate teachers to access learning resources anytime and anywhere. The appropriate information technology is mobile learning. Innovations that can make teachers easy to access learning resources are mobile applications that can be accessed anytime and anywhere either online or offline. The research method was research development method. In preliminary analysis, subjects consist of teachers and lecturers in professional teacher education program. The results that the teachers ready to adopt mobile-learning for the improvement of their skills.

Improving Spacecraft Data Visualization Using Splunk

NASA Technical Reports Server (NTRS)

Conte, Matthew

2012-01-01

EPOXI, like all spacecraft missions, receives large volumes of telemetry data from its spacecraft, DIF. It is extremely important for this data to be updated quickly and presented in a readable manner so that the flight team can monitor the status of the spacecraft. Existing DMD pages for monitoring spacecraft telemetry, while functional, are limited and do not take advantage of modern search technology. For instance, they only display current data points from instruments on the spacecraft and have limited graphing capabilities, making it difficult to see historical data. The DMD pages have fixed refresh rates so the team must often wait several minutes to see the most recent data, even after it is received on the ground. The pages are also rigid and require an investment of time and money to update. To more easily organize and visualize spacecraft telemetry, the EPOXI team has begun experimenting with Splunk, a commercially-available data mining system. Splunk can take data received from the spacecraft's different data channels, often in different formats, and index all the data into a common format. Splunk allows flight team members to search through the different data formats from a single interface and to filter results by time range and data field to make finding specific spacecraft events quick and easy. Furthermore, Splunk provides functions to create custom interfaces which help team members visualize the data in charts and graphs to show how the health of the spacecraft has changed over time.One of the goals of my internship with my mentor, Victor Hwang, was to develop new Splunk interfaces to replace the DMD pages and give the spacecraft team access to historical data and visualizations that were previously unavailable. The specific requirements of these pages are discussed in the next section.

Visualizing astronomy data using VRML

NASA Astrophysics Data System (ADS)

Beeson, Brett; Lancaster, Michael; Barnes, David G.; Bourke, Paul D.; Rixon, Guy T.

2004-09-01

Visualisation is a powerful tool for understanding the large data sets typical of astronomical surveys and can reveal unsuspected relationships and anomalous regions of parameter space which may be difficult to find programatically. Visualisation is a classic information technology for optimising scientific return. We are developing a number of generic on-line visualisation tools as a component of the Australian Virtual Observatory project. The tools will be deployed within the framework of the International Virtual Observatory Alliance (IVOA), and follow agreed-upon standards to make them accessible by other programs and people. We and our IVOA partners plan to utilise new information technologies (such as grid computing and web services) to advance the scientific return of existing and future instrumentation. Here we present a new tool - VOlume - which visualises point data. Visualisation of astronomical data normally requires the local installation of complex software, the downloading of potentially large datasets, and very often time-consuming and tedious data format conversions. VOlume enables the astronomer to visualise data using just a web browser and plug-in. This is achieved using IVOA standards which allow us to pass data between Web Services, Java Servlet Technology and Common Gateway Interface programs. Data from a catalogue server can be streamed in eXtensible Mark-up Language format to a servlet which produces Virtual Reality Modeling Language output. The user selects elements of the catalogue to map to geometry and then visualises the result in a browser plug-in such as Cortona or FreeWRL. Other than requiring an input VOTable format file, VOlume is very general. While its major use will likely be to display and explore astronomical source catalogues, it can easily render other important parameter fields such as the sky and redshift coverage of proposed surveys or the sampling of the visibility plane by a rotation-synthesis interferometer.

Seahawk: moving beyond HTML in Web-based bioinformatics analysis.

PubMed

Gordon, Paul M K; Sensen, Christoph W

2007-06-18

Traditional HTML interfaces for input to and output from Bioinformatics analysis on the Web are highly variable in style, content and data formats. Combining multiple analyses can therefore be an onerous task for biologists. Semantic Web Services allow automated discovery of conceptual links between remote data analysis servers. A shared data ontology and service discovery/execution framework is particularly attractive in Bioinformatics, where data and services are often both disparate and distributed. Instead of biologists copying, pasting and reformatting data between various Web sites, Semantic Web Service protocols such as MOBY-S hold out the promise of seamlessly integrating multi-step analysis. We have developed a program (Seahawk) that allows biologists to intuitively and seamlessly chain together Web Services using a data-centric, rather than the customary service-centric approach. The approach is illustrated with a ferredoxin mutation analysis. Seahawk concentrates on lowering entry barriers for biologists: no prior knowledge of the data ontology, or relevant services is required. In stark contrast to other MOBY-S clients, in Seahawk users simply load Web pages and text files they already work with. Underlying the familiar Web-browser interaction is an XML data engine based on extensible XSLT style sheets, regular expressions, and XPath statements which import existing user data into the MOBY-S format. As an easily accessible applet, Seahawk moves beyond standard Web browser interaction, providing mechanisms for the biologist to concentrate on the analytical task rather than on the technical details of data formats and Web forms. As the MOBY-S protocol nears a 1.0 specification, we expect more biologists to adopt these new semantic-oriented ways of doing Web-based analysis, which empower them to do more complicated, ad hoc analysis workflow creation without the assistance of a programmer.

Seahawk: moving beyond HTML in Web-based bioinformatics analysis

PubMed Central

Gordon, Paul MK; Sensen, Christoph W

2007-01-01

Background Traditional HTML interfaces for input to and output from Bioinformatics analysis on the Web are highly variable in style, content and data formats. Combining multiple analyses can therfore be an onerous task for biologists. Semantic Web Services allow automated discovery of conceptual links between remote data analysis servers. A shared data ontology and service discovery/execution framework is particularly attractive in Bioinformatics, where data and services are often both disparate and distributed. Instead of biologists copying, pasting and reformatting data between various Web sites, Semantic Web Service protocols such as MOBY-S hold out the promise of seamlessly integrating multi-step analysis. Results We have developed a program (Seahawk) that allows biologists to intuitively and seamlessly chain together Web Services using a data-centric, rather than the customary service-centric approach. The approach is illustrated with a ferredoxin mutation analysis. Seahawk concentrates on lowering entry barriers for biologists: no prior knowledge of the data ontology, or relevant services is required. In stark contrast to other MOBY-S clients, in Seahawk users simply load Web pages and text files they already work with. Underlying the familiar Web-browser interaction is an XML data engine based on extensible XSLT style sheets, regular expressions, and XPath statements which import existing user data into the MOBY-S format. Conclusion As an easily accessible applet, Seahawk moves beyond standard Web browser interaction, providing mechanisms for the biologist to concentrate on the analytical task rather than on the technical details of data formats and Web forms. As the MOBY-S protocol nears a 1.0 specification, we expect more biologists to adopt these new semantic-oriented ways of doing Web-based analysis, which empower them to do more complicated, ad hoc analysis workflow creation without the assistance of a programmer. PMID:17577405

Supplement to the Carcinogenic Potency Database (CPDB): Results ofanimal bioassays published in the general literature through 1997 and bythe National Toxicology Program in 1997-1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gold, Lois Swirsky; Manley, Neela B.; Slone, Thomas H.

2005-04-08

The Carcinogenic Potency Database (CPDB) is a systematic and unifying resource that standardizes the results of chronic, long-term animal cancer tests which have been conducted since the 1950s. The analyses include sufficient information on each experiment to permit research into many areas of carcinogenesis. Both qualitative and quantitative information is reported on positive and negative experiments that meet a set of inclusion criteria. A measure of carcinogenic potency, TD50 (daily dose rate in mg/kg body weight/day to induce tumors in half of test animals that would have remained tumor-free at zero dose), is estimated for each tissue-tumor combination reported. Thismore » article is the ninth publication of a chronological plot of the CPDB; it presents results on 560 experiments of 188 chemicals in mice, rats, and hamsters from 185 publications in the general literature updated through 1997, and from 15 Reports of the National Toxicology Program in 1997-1998. The test agents cover a wide variety of uses and chemical classes. The CPDB Web Site(http://potency.berkeley.edu/) presents the combined database of all published plots in a variety of formats as well as summary tables by chemical and by target organ, supplemental materials on dosing and survival, a detailed guide to using the plot formats, and documentation of methods and publications. The overall CPDB, including the results in this article, presents easily accessible results of 6153 experiments on 1485 chemicals from 1426 papers and 429 NCI/NTP (National Cancer Institute/National Toxicology program) Technical Reports. A tab-separated format of the full CPDB for reading the data into spreadsheets or database applications is available on the Web Site.« less

Tools and strategies for instrument monitoring, data mining and data access

NASA Astrophysics Data System (ADS)

van Hees, R. M., ,, Dr

2009-04-01

The ever growing size of data sets produced by various satellite instruments creates a challenge in data management. Three main tasks were identified: instrument performance monitoring, data mining by users and data deployment. In this presentation, I will discuss the three tasks and our solution. As a practical example to illustrate the problem and make the discussion less abstract, I will use Sciamachy on-board the ESA satellite Envisat. Since the launch of Envisat, in March 2002, Sciamachy has performed nearly a billion science measurements and performed daily calibrations measurements. The total size of the data set (not including reprocessed data) is over 30 TB, distributed over 150,000 files. [Instrument Monitoring] Most instruments produce house-keeping data, which may include time, geo-location, temperature of different parts of the instrument and instrument settings and configuration. In addition, many instruments perform calibration measurements. Instrument performance monitoring requires automated analyzes of critical parameters for events, and the option to off-line inspect the behavior of various parameters in time. We choose to extract the necessary information from the SCIAMACHY data products, and store everything in one file, where we separated house-keeping data from calibration measurements. Due to the large volume and the need to have quick random-access, the Hierarchical Data Format (HDF5) was our obvious choice. The HDF5 format is self describing and designed to organize different types of data in one file. For example, one data set may contain the meta data of the calibration measurements: time, geo-location, instrument settings, quality parameters (temperature of the instrument), while a second large data set contains the actual measurements. The HDF5 high-level packet table API is ideal for tables that only grow (by appending rows), while the HDF5 table API is better suited for tables where rows need to be updated, inserted or replaced. In particular, the packet table API allows very compact storage of compound data sets and very fast read/write access. Details about this implementation and pitfalls will be given in the presentation. [Data Mining] The ability to select relevant data is a requirement that all data centers have to offer. The NL-SCIA-DC allows the users to select data using several criteria including: time, geo-location, type of observation and data quality. The result of the query are [i] location and name of relevant data products (files), or [ii] listing of meta data of the relevant measurements, or [iii] listing of the measurements (level 2 or higher). For this application, we need the power of a relational database, the SQL language, and the availability of spatial functions. PostgreSQL, extended with postGIS support turned out to be a good choice. Common queries on tables with millions of rows can be executed within seconds. [Data Deployment] The dissemination of scientific data is often cumbersome by the usage of many different formats to store the products. Therefore, time-consuming and inefficient conversions are needed to use data products from different origin. Within the Atmospheric Data Access for the Geospatial User Community (ADAGUC) project we provide selected space borne atmospheric and land data sets in the same data format and consistent internal structure, so that users can easily use and combine data. The common format for storage is HDF5, but the netCDF-4 API is used to create the data sets. The standard for metadata and dataset attributes follow the netCDF Climate and Forecast conventions, in addition metadata complies to the ISO 19115:2003 INSPIRE profile are added. The advantage of netCDF-4 is that the API is essentially equal to netCDF-3 (with a few extensions), while the data format is HDF5 (recognized by many scientific tools). The added metadata ensures product traceability. Details will be given in the presentation and several posters.

Psyplot: Visualizing rectangular and triangular Climate Model Data with Python

NASA Astrophysics Data System (ADS)

Sommer, Philipp

2016-04-01

The development and use of climate models often requires the visualization of geo-referenced data. Creating visualizations should be fast, attractive, flexible, easily applicable and easily reproducible. There is a wide range of software tools available for visualizing raster data, but they often are inaccessible to many users (e.g. because they are difficult to use in a script or have low flexibility). In order to facilitate easy visualization of geo-referenced data, we developed a new framework called "psyplot," which can aid earth system scientists with their daily work. It is purely written in the programming language Python and primarily built upon the python packages matplotlib, cartopy and xray. The package can visualize data stored on the hard disk (e.g. NetCDF, GeoTIFF, any other file format supported by the xray package), or directly from the memory or Climate Data Operators (CDOs). Furthermore, data can be visualized on a rectangular grid (following or not following the CF Conventions) and on a triangular grid (following the CF or UGRID Conventions). Psyplot visualizes 2D scalar and vector fields, enabling the user to easily manage and format multiple plots at the same time, and to export the plots into all common picture formats and movies covered by the matplotlib package. The package can currently be used in an interactive python session or in python scripts, and will soon be developed for use with a graphical user interface (GUI). Finally, the psyplot framework enables flexible configuration, allows easy integration into other scripts that uses matplotlib, and provides a flexible foundation for further development.

Students Seeking Information for Their Masters' Theses: The Effect of the Internet

ERIC Educational Resources Information Center

Junni, Paulina

2007-01-01

Introduction: The Internet has radically changed the global availability of scholarly publications. Today, a substantial part of the resources accessible for researchers and university students are offered through electronic site licenses, making the supply of easily obtainable information larger than ever. This brings forth an important question:…

Women Choose Their Careers: A Study of Natural Decision Making.

ERIC Educational Resources Information Center

Eisenhart, Margaret A.

1985-01-01

Ethnographic interviews with 23 college-aged women revealed most considered few career alternatives, relied on easily accessible information sources, made choices early in life, stayed with the choice, and decided to either "earn money" or "stay at home." The others considered several alternatives, pursued them, and linked them to relationships…

77 FR 2575 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-18

... the records specified in Rule 17Ad-6 in an easily accessible place for a period of six months to six... agent). The retention period for the recordkeeping requirements under Rule 17Ad-6 is six months to one... records may be maintained using electronic, microfilm, and microfiche storage methods. These recordkeeping...

The Use of Virtual Patients in Medical School Curricula

ERIC Educational Resources Information Center

Cendan, Juan; Lok, Benjamin

2012-01-01

The demonstration of patient-based cases using automated technology [virtual patients (VPs)] has been available to health science educators for a number of decades. Despite the promise of VPs as an easily accessible and moldable platform, their widespread acceptance and integration into medical curricula have been slow. Here, the authors review…

Technology for the Struggling Reader: Free and Easily Accessible Resources

ERIC Educational Resources Information Center

Berkeley, Sheri; Lindstrom, Jennifer H.

2011-01-01

A fundamental problem for many struggling readers, their parents, and their teachers is that there are few benchmarks to guide decision making about assistive technological supports when the nature of a disability is cognitive (e.g., specific learning disability, SLD) rather than physical. However, resources such as the National Center on…

The Effects of a 12-Week Walking Program on Community-Dwelling Older Adults

ERIC Educational Resources Information Center

Cheng, Shun-Ping; Tsai, Tzu-I; Lii, Yun-Kung; Yu, Shu; Chou, Chen-Liang; Chen, I-Ju

2009-01-01

Walking is a popular and easily accessible form of physical activity. However, walking instruction for older adults is based on the evidence gathered from younger populations. This study evaluated walking conditions, strength, balance, and subjective health status after a 12-week walking-training program in community-dwelling adults greater than…

Biochemistry Games: "AZ-Quiz" and "Jeopardy!"

ERIC Educational Resources Information Center

Rostejnska, Milada; Klimova, Helena

2011-01-01

"AZ-Quiz" and "Jeopardy!" are popular television shows and serve as the basis for in-class games designed to support and diversify chemistry instruction at the high school level. Both games were created in Microsoft PowerPoint, which is an easily accessible and controllable instrument that enables the creation of engaging animation. The use of…

Free Fall and Harmonic Oscillations: Analyzing Trampoline Jumps

ERIC Educational Resources Information Center

Pendrill, Ann-Marie; Eager, David

2015-01-01

Trampolines can be found in many gardens and also in some playgrounds. They offer an easily accessible vertical motion that includes free fall. In this work, the motion on a trampoline is modelled by assuming a linear relation between force and deflection, giving harmonic oscillations for small amplitudes. An expression for the cycle-time is…

The Husky Byte Program: Delivering Nutrition Education One Sound Byte at a Time

ERIC Educational Resources Information Center

Pierce, Michelle B.; Hudson, Kerrian A.; Lora, Karina R.; Havens, Erin K.; Ferris, Ann M.

2011-01-01

The Husky Byte program uses interactive displays to deliver quick sound bytes of nutrition information to adults in frequented community settings. This innovative program considers time constraints, adult learning theory, diverse learning styles, and is easily accessible to adults. Both process and impact evaluations have demonstrated positive…

A Field Study of a Video Supported Seamless-Learning-Setting with Elementary Learners

ERIC Educational Resources Information Center

Fößl, Thomas; Ebner, Martin; Schön, Sandra; Holzinger, Andreas

2016-01-01

Seamless Learning shall initiate human learning processes that exceeds lesson and classroom limits. At the same time this approach fosters a self-regulated learning, by means of inspirational, open education settings. Advanced learning materials are easily accessible via mobile digital devices connected to the Internet. In this study it was…

Developing Interactive Educational Engineering Software for the World Wide Web with Java.

ERIC Educational Resources Information Center

Reed, John A.; Afjeh, Abdollah A.

1998-01-01

Illustrates the design and implementation of a Java applet for use in educational propulsion engineering curricula. The Java Gas Turbine Simulator applet provides an interactive graphical environment which allows the rapid, efficient construction and analysis of arbitrary gas turbine systems. The simulator can be easily accessed from the World…

Some Aspects of Grading Java Code Submissions in MOOCs

ERIC Educational Resources Information Center

Király, Sándor; Nehéz, Károly; Hornyák, Olivér

2017-01-01

Recently, massive open online courses (MOOCs) have been offering a new online approach in the field of distance learning and online education. A typical MOOC course consists of video lectures, reading material and easily accessible tests for students. For a computer programming course, it is important to provide interactive, dynamic, online coding…

Active Ingredient - AZ

EPA Pesticide Factsheets

EPA Pesticide Chemical Search allows a user to easily find the pesticide chemical or active ingredient that they are interested in by using an array of simple to advanced search options. Chemical Search provides a single point of reference for easy access to information previously published in a variety of locations, including various EPA web pages and Regulations.gov.

SCIENTIFIC AND TECHNICAL SOCIETIES PERTINENT TO THE EDUCATION OF TECHNICIANS. TECHNICAL EDUCATION PROGRAM SERIES NO. 7.

ERIC Educational Resources Information Center

BROOKING, WALTER J.

THIS LISTING OF SELECTED NATIONAL SCIENTIFIC AND TECHNICAL SOCIETIES WAS PUBLISHED TO ASSIST FEDERAL, STATE, AND LOCAL SCHOOL ADMINISTRATORS, SUPERVISORS, DEPARTMENT HEADS, TEACHERS, LIBRARIANS, AND GUIDANCE PERSONNEL TO UNDERSTAND BETTER THE SERVICES OF SUCH SOCIETIES AND TO PROVIDE AN EASILY ACCESSIBLE AND SCIENTIFIC GUIDE TO THEM. CHAPTER…

Prospects for Gene Therapy in the Fragile X Syndrome

ERIC Educational Resources Information Center

Rattazzi, Mario C.; LaFauci, Giuseppe; Brown, W. Ted

2004-01-01

Gene therapy is unarguably the definitive way to treat, and possibly cure, genetic diseases. A straightforward concept in theory, in practice it has proven difficult to realize, even when directed to easily accessed somatic cell systems. Gene therapy for diseases in which the central nervous system (CNS) is the target organ presents even greater…

Detecting Plagiarism in MS Access Assignments

ERIC Educational Resources Information Center

Singh, Anil

2013-01-01

Assurance of individual effort from students in computer-based assignments is a challenge. Due to digitization, students can easily use a copy of their friend's work and submit it as their own. Plagiarism in assignments puts students who cheat at par with those who work honestly and this compromises the learning evaluation process. Using a…

The Dimensions of the Solar System

ERIC Educational Resources Information Center

Schneider, Stephen E.; Davis, Kathleen S.

2007-01-01

A few new wrinkles have been added to the popular activity of building a scale model of the solar system. Students can learn about maps and scaling using easily accessible online resources that include satellite images. This is accomplished by taking advantage of some of the special features of Google Earth. This activity gives students a much…

75 FR 82135 - Agency Information Collection Activities: Notice of Request for Approval of a New Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-29

... off of the success of three meeting-place based dynamic ridesharing systems that exist in Houston, San... dynamic ridesharing systems operate by having drivers and riders meet at central, easily accessible... they are a critical component to these robust dynamic ridesharing systems which serve thousands of...

ALA Conference 2009: The Second City's Newest Restaurants

ERIC Educational Resources Information Center

Daugherty, Robert Allen

2009-01-01

In this article, the author lists some of his favorites among Chicago's new restaurants. Most of the restaurants listed are easily accessible from the conference hotels by foot, taxi, or public transportation. The Chicago Transit Authority's (CTA) helpful trip planner can be used to determine the quickest and easiest routes. The price guide is…

Introducing ISTE Learning: What Do You Want to Learn Today?

ERIC Educational Resources Information Center

Hayman, April

2011-01-01

This article introduces ISTE Learning, a new online professional development (PD) program designed specifically to make PD both fun and more easily accessible for busy educators. One thing that makes ISTE Learning different from everything else out there is that the NETS for students, teachers, and administrators are the cornerstone of everything…

Integrating Free Computer Software in Chemistry and Biochemistry Instruction: An International Collaboration

ERIC Educational Resources Information Center

Cedeno, David L.; Jones, Marjorie A.; Friesen, Jon A.; Wirtz, Mark W.; Rios, Luz Amalia; Ocampo, Gonzalo Taborda

2010-01-01

At the Universidad de Caldas, Manizales, Colombia, we used their new computer facilities to introduce chemistry graduate students to biochemical database mining and quantum chemistry calculations using freeware. These hands-on workshops allowed the students a strong introduction to easily accessible software and how to use this software to begin…

Student Teachers' Intrinsic Motivation during a Short-Term Teacher Training Course Abroad

ERIC Educational Resources Information Center

Pfingsthorn, Joanna; Czura, Anna

2017-01-01

While research data concerning study abroad experiences of tertiary level students are easily accessible, relatively little attention has been paid to the role of international programmes in pre-service foreign language (FL) teacher education. The present study involved student teachers of English from three countries and aimed to explore their…