Sample records for ebmt-saa working party

  1. Protective environment for hematopoietic cell transplant (HSCT) recipients: The Infectious Diseases Working Party EBMT analysis of global recommendations on health-care facilities.

    PubMed

    Styczynski, Jan; Tridello, Gloria; Donnelly, J Peter; Iacobelli, Simona; Hoek, Jennifer; Mikulska, Malgorzata; Aljurf, Mahmoud; Gil, Lidia; Cesaro, Simone

    2018-03-13

    International guidelines on protective environment for HSCT recipients proposed a set of 10 global recommendations in 2009 on protective environment (GRPE) concerning hospital room design and ventilation. The EBMT Infectious Diseases Working Party undertook a survey on the status on protective environment for HSCT recipients with the aim of surveying current practices and their agreement with GRPE recommendations. The questionnaire consisted of 37 questions divided into 5 sections about filtration, air changes, maintenance, and the protective environment in rooms and the surrounding unit. Overall, 177 centres (response rate 33%) from 36 countries responded, indicating that 99.4% of patient rooms were equipped with HEPA filters, but only 48.6% of the centre's staff were aware of, and could confirm, regular replacement of filters based on manufacturers' recommendations. Well-sealed rooms were used in terms of windows (70.6%), ceilings (35%), and plumbing pipes (51.4%). The sensor monitors in the patient room used to determine when the HEPA filters require changing were installed only in 18.1% of centres. Only 1 centre fulfilled all 10 GRPE recommendations, while 62 centres fulfilled the 3 level "A" recommendations. In conclusion, HEPA-filtered rooms are available in almost all centres, while fewer centres fulfilled other requirements. Knowledge on the details and maintenance of protective environments in the HSCT setting was inadequate, reflecting a lack of communication between the health personnel involved, hospital infection control and the hospital maintenance services.

  2. Universal SaaS platform of internet of things for real-time monitoring

    NASA Astrophysics Data System (ADS)

    Liu, Tongke; Wu, Gang

    2018-04-01

    Real-time monitoring service, as a member of the IoT (Internet of Things) service, has a wide range application scenario. To support rapid construction and deployment of applications and avoid repetitive development works in these processes, this paper designs and develops a universal SaaS platform of IoT for real-time monitoring. Evaluation shows that this platform can provide SaaS service to multiple tenants and achieve high real-time performance under the situation of large amount of device access.

  3. Connecting long-tail scientists with big data centers using SaaS

    NASA Astrophysics Data System (ADS)

    Percivall, G. S.; Bermudez, L. E.

    2012-12-01

    Big data centers and long tail scientists represent two extremes in the geoscience research community. Interoperability and inter-use based on software-as-a-service (SaaS) increases access to big data holdings by this underserved community of scientists. Large, institutional data centers have long been recognized as vital resources in the geoscience community. Permanent data archiving and dissemination centers provide "access to the data and (are) a critical source of people who have experience in the use of the data and can provide advice and counsel for new applications." [NRC] The "long-tail of science" is the geoscience researchers that work separate from institutional data centers [Heidorn]. Long-tail scientists need to be efficient consumers of data from large, institutional data centers. Discussions in NSF EarthCube capture the challenges: "Like the vast majority of NSF-funded researchers, Alice (a long-tail scientist) works with limited resources. In the absence of suitable expertise and infrastructure, the apparently simple task that she assigns to her graduate student becomes an information discovery and management nightmare. Downloading and transforming datasets takes weeks." [Foster, et.al.] The long-tail metaphor points to methods to bridge the gap, i.e., the Web. A decade ago, OGC began building a geospatial information space using open, web standards for geoprocessing [ORM]. Recently, [Foster, et.al.] accurately observed that "by adopting, adapting, and applying semantic web and SaaS technologies, we can make the use of geoscience data as easy and convenient as consumption of online media." SaaS places web services into Cloud Computing. SaaS for geospatial is emerging rapidly building on the first-generation geospatial web, e.g., OGC Web Coverage Service [WCS] and the Data Access Protocol [DAP]. Several recent examples show progress in applying SaaS to geosciences: - NASA's Earth Data Coherent Web has a goal to improve science user experience using

  4. Paradoxical effects of SAA on lipoprotein oxidation suggest a new antioxidant function for SAA[S

    PubMed Central

    Jayaraman, Shobini; Haupt, Christian

    2016-01-01

    Oxidative stress and inflammation, which involve a dramatic increase in serum amyloid A (SAA) levels, are critical in the development of atherosclerosis. Most SAA circulates on plasma HDL particles, altering their cardioprotective properties. SAA-enriched HDL has diminished anti-oxidant effects on LDL, which may contribute to atherogenesis. We determined combined effects of SAA enrichment and oxidation on biochemical changes in HDL. Normal human HDLs were incubated with SAA, oxidized by various factors (Cu2+, myeloperoxidase, H2O2, OCl−), and analyzed for lipid and protein modifications and biophysical remodeling. Three novel findings are reported: addition of SAA reduces oxidation of HDL and LDL lipids; oxidation of SAA-containing HDL in the presence of OCl− generates a covalent heterodimer of SAA and apoA-I that resists the release from HDL; and mild oxidation promotes spontaneous release of proteins (SAA and apoA-I) from SAA-enriched HDL. We show that the anti-oxidant effects of SAA extend to various oxidants and are mediated mainly by the unbound protein. We propose that free SAA sequesters lipid hydroperoxides and delays lipoprotein oxidation, though much less efficiently than other anti-oxidant proteins, such as apoA-I, that SAA displaces from HDL. These findings prompt us to reconsider the role of SAA in lipid oxidation in vivo. PMID:27744369

  5. Evaluating the impact of virtualization characteristics on SaaS adoption

    NASA Astrophysics Data System (ADS)

    Tomás, Sara; Thomas, Manoj; Oliveira, Tiago

    2018-03-01

    Software as a service (SaaS) is a service model in which the applications are accessible from various client devices through internet. Several studies report possible factors driving the adoption of SaaS but none have considered the perception of the SaaS features and the organization's context. We propose an integrated research model that combines the process virtualization theory (PVT), the technology-organization-environment (TOE) framework and the institutional theory (INT). PVT seeks to explain whether processes are suitable for migration into virtual environments via an information technology-based mechanism as SaaS. The TOE framework seeks to explain the effects of the intra-organizational factors, while INT seeks to explain the effects of the inter-organizational factors on the technology adoption. This research addresses a gap in the SaaS adoption literature by studying the internal perception of the technical features of SaaS and technology, organization, and environment perspectives. Additionally, the integration of PVT, the TOE framework, and INT contributes to the information system (IS) discipline, deepening the applicability and strengths of these theories.

  6. A Systematic Process for Developing High Quality SaaS Cloud Services

    NASA Astrophysics Data System (ADS)

    La, Hyun Jung; Kim, Soo Dong

    Software-as-a-Service (SaaS) is a type of cloud service which provides software functionality through Internet. Its benefits are well received in academia and industry. To fully utilize the benefits, there should be effective methodologies to support the development of SaaS services which provide high reusability and applicability. Conventional approaches such as object-oriented methods do not effectively support SaaS-specific engineering activities such as modeling common features, variability, and designing quality services. In this paper, we present a systematic process for developing high quality SaaS and highlight the essentiality of commonality and variability (C&V) modeling to maximize the reusability. We first define criteria for designing the process model and provide a theoretical foundation for SaaS; its meta-model and C&V model. We clarify the notion of commonality and variability in SaaS, and propose a SaaS development process which is accompanied with engineering instructions. Using the proposed process, SaaS services with high quality can be effectively developed.

  7. Similar outcome of upfront-unrelated and matched sibling stem cell transplantation in idiopathic paediatric aplastic anaemia. A study on behalf of the UK Paediatric BMT Working Party, Paediatric Diseases Working Party and Severe Aplastic Anaemia Working Party of EBMT.

    PubMed

    Dufour, Carlo; Veys, Paul; Carraro, Elisa; Bhatnagar, Neha; Pillon, Marta; Wynn, Rob; Gibson, Brenda; Vora, Ajay J; Steward, Colin G; Ewins, Anna M; Hough, Rachael E; de la Fuente, Josu; Velangi, Mark; Amrolia, Persis J; Skinner, Roderick; Bacigalupo, Andrea; Risitano, Antonio M; Socie, Gerard; Peffault de Latour, Regis; Passweg, Jakob; Rovo, Alicia; Tichelli, André; Schrezenmeier, Hubert; Hochsmann, Britta; Bader, Peter; van Biezen, Anja; Aljurf, Mahmoud D; Kulasekararaj, Austin; Marsh, Judith C; Samarasinghe, Sujith

    2015-11-01

    We explored the feasibility of unrelated donor haematopoietic stem cell transplant (HSCT) upfront without prior immunosuppressive therapy (IST) in paediatric idiopathic severe aplastic anaemia (SAA). This cohort was then compared to matched historical controls who had undergone first-line therapy with a matched sibling/family donor (MSD) HSCT (n = 87) or IST with horse antithymocyte globulin and ciclosporin (n = 58) or second-line therapy with unrelated donor HSCT post-failed IST (n = 24). The 2-year overall survival in the upfront cohort was 96 ± 4% compared to 91 ± 3% in the MSD controls (P = 0·30) and 94 ± 3% in the IST controls (P = 0·68) and 74 ± 9% in the unrelated donor HSCT post-IST failure controls (P = 0·02).The 2-year event-free survival in the upfront cohort was 92 ± 5% compared to 87 ± 4% in MSD controls (P = 0·37), 40 ± 7% in IST controls (P = 0·0001) and 74 ± 9% in the unrelated donor HSCT post-IST failure controls (n = 24) (P = 0·02). Outcomes for upfront-unrelated donor HSCT in paediatric idiopathic SAA were similar to MSD HSCT and superior to IST and unrelated donor HSCT post-IST failure. Front-line therapy with matched unrelated donor HSCT is a novel treatment approach and could be considered as first-line therapy in selected paediatric patients who lack a MSD. © 2015 John Wiley & Sons Ltd.

  8. Measurement of serum amyloid A1 (SAA1), a major isotype of acute phase SAA.

    PubMed

    Xu, Yuanyuan; Yamada, Toshiyuki; Satoh, Takahiko; Okuda, Yasuaki

    2006-01-01

    Serum amyloid A (SAA), a plasma precursor of reactive amyloid deposits, is a multigene product. SAA1 and SAA2, with primary structures that are 93% identical (98 of 104 amino acids), behave as acute phase proteins, as demonstrated by their increasing levels in plasma. Heretofore, it has been understood that SAA1 predominates and functions as an isotype in plasma. However, accurate measurements differentiating the two isotypes have not been reported. In this study, using monoclonal antibodies specific for SAA1, we developed an enzyme-linked immunosorbent assay (ELISA) for SAA1. The levels and ratios of SAA1 in total SAA (TSAA) were investigated in healthy subjects and patients with rheumatoid arthritis (RA). The SAA1/TSAA ratio was 74 +/- 12% and 77 +/- 12% in healthy subjects and RA patients, respectively. In RA patients, the ratios were not influenced by SAA1 genotype, which has been proposed to affect plasma SAA values. The kinetics of SAA1 in inflamed patients undergoing hemodialysis was found to be parallel with total SAA and C-reactive protein. Finally, this study confirmed that SAA1 is a major isotype of acute phase SAA and may determine total SAA values. This specific assay could be used in the evaluation of SAA behavior in several clinical conditions.

  9. Research on SaaS and Web Service Based Order Tracking

    NASA Astrophysics Data System (ADS)

    Jiang, Jianhua; Sheng, Buyun; Gong, Lixiong; Yang, Mingzhong

    To solve the order tracking of across enterprises in Dynamic Virtual Enterprise (DVE), a SaaS and web service based order tracking solution was designed by analyzing the order management process in DVE. To achieve the system, the SaaS based architecture of data management on order tasks manufacturing states was constructed, and the encapsulation method of transforming application system into web service was researched. Then the process of order tracking in the system was given out. Finally, the feasibility of this study was verified by the development of a prototype system.

  10. A Mechanism of Modeling and Verification for SaaS Customization Based on TLA

    NASA Astrophysics Data System (ADS)

    Luan, Shuai; Shi, Yuliang; Wang, Haiyang

    With the gradually mature of SOA and the rapid development of Internet, SaaS has become a popular software service mode. The customized action of SaaS is usually subject to internal and external dependency relationships. This paper first introduces a method for modeling customization process based on Temporal Logic of Actions, and then proposes a verification algorithm to assure that each step in customization will not cause unpredictable influence on system and follow the related rules defined by SaaS provider.

  11. Characterization of rat serum amyloid A4 (SAA4): A novel member of the SAA superfamily

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rossmann, Christine; Windpassinger, Christian; Brunner, Daniela

    2014-08-08

    Highlights: • The full length rat SAA4 (rSAA4) mRNA was characterized by rapid amplification of cDNA ends. • rSAA4 mRNA has 1830 bases including a GA dinucleotide tandem repeat in the 5′UTR. • Three consecutive C/EBP promoter elements are crucial for transcription of rSAA4. • rSAA4 is abundantly expressed in the liver on mRNA and protein level. - Abstract: The serum amyloid A (SAA) family of proteins is encoded by multiple genes, which display allelic variation and a high degree of homology in mammals. The SAA1/2 genes code for non-glycosylated acute-phase SAA1/2 proteins, that may increase up to 1000-fold duringmore » inflammation. The SAA4 gene, well characterized in humans (hSAA4) and mice (mSaa4) codes for a SAA4 protein that is glycosylated only in humans. We here report on a previously uncharacterized SAA4 gene (rSAA4) and its product in Rattus norvegicus, the only mammalian species known not to express acute-phase SAA. The exon/intron organization of rSAA4 is similar to that reported for hSAA4 and mSaa4. By performing 5′- and 3′RACE, we identified a 1830-bases containing rSAA4 mRNA (including a GA-dinucleotide tandem repeat). Highest rSAA4 mRNA expression was detected in rat liver. In McA-RH7777 rat hepatoma cells, rSAA4 transcription was significantly upregulated in response to LPS and IL-6 while IL-1α/β and TNFα were without effect. Luciferase assays with promoter-truncation constructs identified three proximal C/EBP-elements that mediate expression of rSAA4 in McA-RH7777 cells. In line with sequence prediction a 14-kDa non-glycosylated SAA4 protein is abundantly expressed in rat liver. Fluorescence microscopy revealed predominant localization of rSAA4-GFP-tagged fusion protein in the ER.« less

  12. Quantification of SAA1 and SAA2 in lung cancer plasma using the isotype-specific PRM assays.

    PubMed

    Kim, Yeoun Jin; Gallien, Sebastien; El-Khoury, Victoria; Goswami, Panchali; Sertamo, Katriina; Schlesser, Marc; Berchem, Guy; Domon, Bruno

    2015-09-01

    The quantification of plasma proteins using the high resolution and accurate mass (HR/AM)-based parallel reaction monitoring (PRM) method provides an immediate benefit over the conventional SRM-based method in terms of selectivity. In this study, multiplexed PRM assays were developed to analyze isotypes of serum amyloid A (SAA) proteins in human plasma with a focus on SAA1 and SAA2. Elevated plasma levels of these proteins in patients diagnosed with lung cancer have been reported in previous studies. Since SAA1 and SAA2 are highly homologous, the available immunoassays tend to overestimate their concentrations due to cross-reactivity. On the other hand, when mass spectrometry (MS)-based assays are used, the presence of the several allelic variants may result in a problem of underestimation. In the present study, eight peptides that represent the target proteins at three different levels: isotype-specific (SAA1α,  SAA 1β,  SAA1γ,  SAA2α,  SAA2β), protein-specific (SAA1 or SAA2), and pan SAA (SAA1 and SAA2) were chosen to differentiate SAAs in lung cancer plasma samples using a panel of PRM assays. The measurement of specific isotypes, leveraging the analytical performance of PRM, allowed to quantify the allelic variants of both target proteins. The isotypes detected were corroborated with the genetic information obtained from the same samples. The combination of SAA2α and SAA2β assays representing the total SAA2 concentration demonstrated a superior analytical outcome than the previously used assay on the common peptide when applied to the detection of lung cancer. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Outcomes of haploidentical stem cell transplantation for chronic lymphocytic leukemia: a retrospective study on behalf of the chronic malignancies working party of the EBMT.

    PubMed

    van Gorkom, Gwendolyn; van Gelder, Michel; Eikema, Dirk-Jan; Blok, Henric-Jan; van Lint, M T; Koc, Yener; Ciceri, Fabio; Beelen, Dietrich; Chevallier, Patrice; Selleslag, Dominik; Blaise, Didier; Foá, Roberto; Corradini, Paolo; Castagna, Luca; Moreno, Carol; Solano, Carlos; Müller, Lutz Peter; Tischer, Johanna; Hilgendorf, Inken; Hallek, Michael; Bittenbring, Jörg; Theobald, Matthias; Schetelig, Johannes; Kröger, Nicolaus

    2018-03-01

    Allogeneic hematopoietic stem cell transplantation (HCT) may result in long-term disease control in high-risk chronic lymphocytic leukemia (CLL). Recently, haploidentical HCT is gaining interest because of better outcomes with post-transplantation cyclophosphamide (PTCY). We analyzed patients with CLL who received an allogeneic HCT with a haploidentical donor and whose data were available in the EBMT registry. In total 117 patients (74% males) were included; 38% received PTCY as GVHD prophylaxis. For the whole study cohort OS at 2 and 5 yrs was 48 and 38%, respectively. PFS at 2 and 5 yrs was 38 and 31%, respectively. Cumulative incidence (CI) of NRM in the whole group at 2 and 5 years were 40 and 44%, respectively. CI of relapse at 2 and 5 yrs were 22 and 26%, respectively. All outcomes were not statistically different in patients who received PTCY compared to other types of GVHD prophylaxis. In conclusion, results of haploidentical HCT in CLL seem almost identical to those with HLA-matched donors. Thereby, haploidentical HCT is an appropriate alternative in high risk CLL patients with a transplant indication but no available HLA-matched donor. Despite the use of PTCY, the CI of relapse seems not higher than observed after HLA-matched HCT.

  14. Sourcing Lifecycle for Software as a Service (SAAS)

    NASA Astrophysics Data System (ADS)

    Santy; Sikkel, K.

    2014-03-01

    In recent years, Software as a Service (SaaS) has changed from curiosity caused concept to an accepted well known concept. A key advantage of this model is that, by cautious engineering, it is possible to influence economy of scale to decrease total cost of ownership compared to on-premises solutions. By using the guideline elaborated in this paper, companies which has interest in implementing SaaS will be led throughout the entire implementation cycle starting before the company decides to implement SaaS until the stage when the company decides to shift from SaaS model to another model or when they shift to another SaaS company

  15. Challenges in Small Screening Laboratories: SaaS to the rescue

    PubMed Central

    Lemmon, Vance P.; Jia, Yuanyuan; Shi, Yan; Holbrook, S. Douglas; Bixby, John L; Buchser, William

    2012-01-01

    The Miami Project to Cure Paralysis, part of the University of Miami Miller School of Medicine, includes a laboratory devoted to High Content Analysis (HCA) of neurons. The goal of the laboratory is to uncover signalling pathways, genes, compounds, or drugs that can be used to promote nerve growth. HCA permits the quantification of neuronal morphology, including the lengths and numbers of axons. HCA screening of various libraries on primary neurons requires a team-based approach, a variety of process steps and complex manipulations of cells and libraries to obtain meaningful results. HCA itself produces vast amounts of information including images, well-based data and cell-based phenotypic measures. Managing experimental workflow and library data, along with the extensive amount of experimental results is challenging. For academic laboratories generating large data sets from experiments using thousands of perturbagens, a laboratory information management system (LIMS) is the data tracking solution of choice. With both productivity and efficiency as driving rationales, the Miami Project has equipped its HCA laboratory with a Software As A Service (SAAS) LIMS to ensure the quality of its experiments and workflows. The article discusses this application in detail, and how the system was selected and integrated into the laboratory. The advantages of SaaS are described. PMID:21631415

  16. Ibrutinib for bridging to allogeneic hematopoietic cell transplantation in patients with chronic lymphocytic leukemia or mantle cell lymphoma: a study by the EBMT Chronic Malignancies and Lymphoma Working Parties.

    PubMed

    Dreger, Peter; Michallet, Mauricette; Bosman, Paul; Dietrich, Sascha; Sobh, Mohamad; Boumendil, Ariane; Nagler, Arnon; Scheid, Christof; Cornelissen, Jan; Niederwieser, Dietger; Müller, Lutz; Vandenberghe, Elizabeth; Scortechini, Ilaria; Schoemans, Helene; Andersen, Niels S; Finke, Jürgen; Russo, Domenico; Ljungman, Per; Passweg, Jakob; van Gelder, Michel; Durakovic, Nadira; Labussiere-Wallet, Helene; Berg, Tobias; Wulf, Gerald; Bethge, Wolfgang; Bunjes, Donald; Stilgenbauer, Stefan; Canepari, Maria Elisa; Schaap, Michel; Fox, Christopher P; Kröger, Nicolaus; Montoto, Silvia; Schetelig, Johannes

    2018-05-04

    The aim of this retrospective study was to investigate the safety and efficacy of allogeneic hematopoietic cell transplantation (alloHCT) in patients pre-treated with ibrutinib. Eligible were patients aged >18 years allotransplanted for chronic lymphocytic leukemia (CLL) or mantle cell lymphoma (MCL) after prior exposure to ibrutinib who were registered with the EBMT registry. Seventy patients (CLL 48, MCL 22) were included. At the time of alloHCT, 73% of the patients were ibrutinib responsive. All patients except one engrafted, and acute GVHD grade 2-4 (3-4) was observed in 49% (12%) of 68 evaluable patients. The cumulative incidence of chronic GVHD was 54% 1 year after transplant. In the CLL group, 12-month non-relapse mortality, relapse incidence (RI), progression-free survival (PFS), and overall survival (OS) were 10, 30, 60, and 72%, respectively, and in the MCL group 5, 19, 76, and 86%, respectively. Pre-transplant ibrutinib failure and poor performance status predicted inferior RI, PFS and OS in the CLL group. In conclusion, ibrutinib does not affect the safety of a subsequent alloHCT. While the relatively high post-transplant relapse risk in ibrutinib-exposed patients with CLL deserves further study, in patients with MCL consolidating disease responses to ibrutinib with alloHCT seems to be a promising option.

  17. The impact of HLA matching on long-term transplant outcome after allogeneic hematopoietic stem cell transplantation for CLL: a retrospective study from the EBMT registry.

    PubMed

    Michallet, M; Sobh, M; Milligan, D; Morisset, S; Niederwieser, D; Koza, V; Ruutu, T; Russell, N H; Verdonck, L; Dhedin, N; Vitek, A; Boogaerts, M; Vindelov, L; Finke, J; Dubois, V; van Biezen, A; Brand, R; de Witte, T; Dreger, P

    2010-10-01

    We analyzed 368 chronic lymphocytic leukemia patients who underwent allogeneic hematopoietic stem cell transplantation reported to the EBMT registry between 1995 and 2007. There were 198 human leukocyte antigen (HLA)-identical siblings; among unrelated transplants, 31 were well matched in high resolution ('well matched' unrelated donor, WMUD), and 139 were mismatched (MM), including 30 matched in low resolution; 266 patients (72%) received reduced-intensity conditioning and 102 (28%) received standard. According to the EBMT risk score, 11% were in scores 1-3, 23% in score 4, 40% in score 5, 22% in score 6 and 4% in score 7. There was no difference in overall survival (OS) at 5 years between HLA-identical siblings (55% (48-64)) and WMUD (59% (41-84)), P=0.82. In contrast, OS was significantly worse for MM (37% (29-48) P=0.005) due to a significant excess of transplant-related mortality. Also OS worsened significantly when EBMT risk score increased. HLA matching had no significant impact on relapse (siblings: 24% (21-27); WMUD: 35% (26-44), P=0.11 and MM: 21% (18-24), P=0.81); alemtuzumab T-cell depletion and stem cell source (peripheral blood) were associated with an increased risk. Our findings support the use of WMUD as equivalent alternative to HLA-matched sibling donors for allogeneic HSCT in CLL, and justify the application of EBMT risk score in this disease.

  18. Allogeneic stem cell transplantation in patients with atypical chronic myeloid leukaemia: a retrospective study from the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation.

    PubMed

    Onida, Francesco; de Wreede, Liesbeth C; van Biezen, Anja; Eikema, Diderik-Jan; Byrne, Jenny L; Iori, Anna P; Schots, Rik; Jungova, Alexandra; Schetelig, Johannes; Finke, Jürgen; Veelken, Hendrik; Johansson, Jan-Erik; Craddock, Charles; Stelljes, Matthias; Theobald, Matthias; Holler, Ernst; Schanz, Urs; Schaap, Nicolaas; Bittenbring, Jörg; Olavarria, Eduardo; Chalandon, Yves; Kröger, Nicolaus

    2017-06-01

    Atypical chronic myeloid leukaemia (aCML) is an aggressive malignancy for which allogeneic haematopoietic stem cell transplantation (allo-HSCT) represents the only curative option. We describe transplant outcomes in 42 patients reported to the European Society for Blood and Marrow Transplantation (EBMT) registry who underwent allo-HSCT for aCML between 1997 and 2006. Median age was 46 years. Median time from diagnosis to transplant was 7 months. Disease status was first chronic phase in 69%. Donors were human leucocyte antigen (HLA)-identical siblings in 64% and matched unrelated (MUD) in 36%. A reduced intensity conditioning was employed in 24% of patients. T-cell depletion was applied in 87% and 26% of transplants from MUD and HLA-identical siblings, respectively. According to the EBMT risk-score, 45% of patients were 'low-risk', 31% 'intermediate-risk' and 24% 'high-risk'. Following allo-HSCT, 87% of patients achieved complete remission. At 5 years, relapse-free survival was 36% and non-relapse mortality (NRM) was 24%, while relapse occurred in 40%. Patient age and the EBMT score had an impact on overall survival. Relapse-free survival was higher in MUD than in HLA-identical sibling HSCT, with no difference in NRM. In conclusion, this study confirmed that allo-HSCT represents a valid strategy to achieve cure in a reasonable proportion of patients with aCML, with young patients with low EBMT risk score being the best candidates. © 2017 John Wiley & Sons Ltd.

  19. Development, preliminary usability and accuracy testing of the EBMT 'eGVHD App' to support GvHD assessment according to NIH criteria-a proof of concept.

    PubMed

    Schoemans, H; Goris, K; Durm, R V; Vanhoof, J; Wolff, D; Greinix, H; Pavletic, S; Lee, S J; Maertens, J; Geest, S D; Dobbels, F; Duarte, R F

    2016-08-01

    The EBMT Complications and Quality of Life Working Party has developed a computer-based algorithm, the 'eGVHD App', using a user-centered design process. Accuracy was tested using a quasi-experimental crossover design with four expert-reviewed case vignettes in a convenience sample of 28 clinical professionals. Perceived usefulness was evaluated by the technology acceptance model (TAM) and User satisfaction by the Post-Study System Usability Questionnaire (PSSUQ). User experience was positive, with a median of 6 TAM points (interquartile range: 1) and beneficial median total, and subscale PSSUQ scores. The initial standard practice assessment of the vignettes yielded 65% correct results for diagnosis and 45% for scoring. The 'eGVHD App' significantly increased diagnostic and scoring accuracy to 93% (+28%) and 88% (+43%), respectively (both P<0.05). The same trend was observed in the repeated analysis of case 2: accuracy improved by using the App (+31% for diagnosis and +39% for scoring), whereas performance tended to decrease once the App was taken away. The 'eGVHD App' could dramatically improve the quality of care and research as it increased the performance of the whole user group by about 30% at the first assessment and showed a trend for improvement of individual performance on repeated case evaluation.

  20. ATI SAA Annex 3 Button Tensile Test Report I

    NASA Technical Reports Server (NTRS)

    Tang, Henry H.

    2013-01-01

    This report documents the results of a study carried out under Splace Act Agreement SAA-EA-10-004 between the National Aeronautics and Space Administration (NASA) and Astro Technology Incorpporated (ATI). NASA and ATI have entered into this agreement to collaborate on the development of technologies that can benefit both the US government space programs and the oil and gas industry. The report documents the results of a test done on an adnesive system for attaching new monitoring sensor devices to pipelines under Annex III of SAA-EA-10-004: "Proof-of-Concept Design and Testing of a Post Installed Sensing Device on Subsea Risers and Pipelines". The tasks of Annex III are to design and test a proof-of-concept sensing device for in-situ installation on pipelines, risers, or other structures deployed in deep water. The function of the sensor device is to measure various signals such as strain, stress and temperature. This study complements the work done, in Annex I of the SAA, on attaching a fiber optic sensing device to pipe via adhesive bonding. Both Annex I and Annex III studies were conducted in the Crew and Thermal System Division (CTSD) at the Johnson Space Center (JSC) in collaboration with ATI.

  1. Detoxification of Corncob Acid Hydrolysate with SAA Pretreatment and Xylitol Production by Immobilized Candida tropicalis

    PubMed Central

    Deng, Li-Hong; Tang, Yong; Liu, Yun

    2014-01-01

    Xylitol fermentation production from corncob acid hydrolysate has become an attractive and promising process. However, corncob acid hydrolysate cannot be directly used as fermentation substrate owing to various inhibitors. In this work, soaking in aqueous ammonia (SAA) pretreatment was employed to reduce the inhibitors in acid hydrolysate. After detoxification, the corncob acid hydrolysate was fermented by immobilized Candida tropicalis cell to produce xylitol. Results revealed that SAA pretreatment showed high delignification and efficient removal of acetyl group compounds without effect on cellulose and xylan content. Acetic acid was completely removed, and the content of phenolic compounds was reduced by 80%. Furthermore, kinetic behaviors of xylitol production by immobilized C. tropicalis cell were elucidated from corncob acid hydrolysate detoxified with SAA pretreatment and two-step adsorption method, respectively. The immobilized C. tropicalis cell showed higher productivity efficiency using the corncob acid hydrolysate as fermentation substrate after detoxification with SAA pretreatment than by two-step adsorption method in the five successive batch fermentation rounds. After the fifth round fermentation, about 60 g xylitol/L fermentation substrate was obtained for SAA pretreatment detoxification, while about 30 g xylitol/L fermentation substrate was obtained for two-step adsorption detoxification. PMID:25133211

  2. Development and analytical performance evaluation of FREND-SAA and FREND-Hp

    NASA Astrophysics Data System (ADS)

    Choi, Eunha; Seong, Jihyun; Lee, Seiyoung; Han, Sunmi

    2017-07-01

    The FREND System is a portable cartridge reader, quantifying analytes by measuring laser-induced fluorescence in a single-use reagent cartridge. The objective of this study was to evaluate FREND-SAA and FREND-Hp assays. The FREND-SAA and Hp assays were standardized to the WHO and IFCC reference materials. Analytical performance studies of Precision, Linearity, Limits of Detections, Interferences, and Method Comparisons for both assays were performed according to the CLSI guidelines. Both assays demonstrated acceptable imprecision of %CV in three different levels of samples. The linearity of the assays was found to be acceptable (SAA 5 150 mg/L, Hp 30 400 mg/dL). The detection limits were 3.8 mg/L (SAA) and 10.2 mg/dL (Hp). No significant interference and no significant deviation from linearity was found in the both comparison studies. In conclusion, NanoEnTek's FREND-SAA and Hp assays represent rapid, accurate and convenient means to quantify SAA and Hp in human serum on FREND system.

  3. Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits.

    PubMed

    Atkins, Norman; Mitchell, Jennifer W; Romanova, Elena V; Morgan, Daniel J; Cominski, Tara P; Ecker, Jennifer L; Pintar, John E; Sweedler, Jonathan V; Gillette, Martha U

    2010-09-07

    Neuropeptides are critical integrative elements within the central circadian clock in the suprachiasmatic nucleus (SCN), where they mediate both cell-to-cell synchronization and phase adjustments that cause light entrainment. Forward peptidomics identified little SAAS, derived from the proSAAS prohormone, among novel SCN peptides, but its role in the SCN is poorly understood. Little SAAS localization and co-expression with established SCN neuropeptides were evaluated by immunohistochemistry using highly specific antisera and stereological analysis. Functional context was assessed relative to c-FOS induction in light-stimulated animals and on neuronal circadian rhythms in glutamate-stimulated brain slices. We found that little SAAS-expressing neurons comprise the third most abundant neuropeptidergic class (16.4%) with unusual functional circuit contexts. Little SAAS is localized within the densely retinorecipient central SCN of both rat and mouse, but not the retinohypothalamic tract (RHT). Some little SAAS colocalizes with vasoactive intestinal polypeptide (VIP) or gastrin-releasing peptide (GRP), known mediators of light signals, but not arginine vasopressin (AVP). Nearly 50% of little SAAS neurons express c-FOS in response to light exposure in early night. Blockade of signals that relay light information, via NMDA receptors or VIP- and GRP-cognate receptors, has no effect on phase delays of circadian rhythms induced by little SAAS. Little SAAS relays signals downstream of light/glutamatergic signaling from eye to SCN, and independent of VIP and GRP action. These findings suggest that little SAAS forms a third SCN neuropeptidergic system, processing light information and activating phase-shifts within novel circuits of the central circadian clock.

  4. Circadian Integration of Glutamatergic Signals by Little SAAS in Novel Suprachiasmatic Circuits

    PubMed Central

    Atkins, Norman; Mitchell, Jennifer W.; Romanova, Elena V.; Morgan, Daniel J.; Cominski, Tara P.; Ecker, Jennifer L.; Pintar, John E.; Sweedler, Jonathan V.; Gillette, Martha U.

    2010-01-01

    Background Neuropeptides are critical integrative elements within the central circadian clock in the suprachiasmatic nucleus (SCN), where they mediate both cell-to-cell synchronization and phase adjustments that cause light entrainment. Forward peptidomics identified little SAAS, derived from the proSAAS prohormone, among novel SCN peptides, but its role in the SCN is poorly understood. Methodology/Principal Findings Little SAAS localization and co-expression with established SCN neuropeptides were evaluated by immunohistochemistry using highly specific antisera and stereological analysis. Functional context was assessed relative to c-FOS induction in light-stimulated animals and on neuronal circadian rhythms in glutamate-stimulated brain slices. We found that little SAAS-expressing neurons comprise the third most abundant neuropeptidergic class (16.4%) with unusual functional circuit contexts. Little SAAS is localized within the densely retinorecipient central SCN of both rat and mouse, but not the retinohypothalamic tract (RHT). Some little SAAS colocalizes with vasoactive intestinal polypeptide (VIP) or gastrin-releasing peptide (GRP), known mediators of light signals, but not arginine vasopressin (AVP). Nearly 50% of little SAAS neurons express c-FOS in response to light exposure in early night. Blockade of signals that relay light information, via NMDA receptors or VIP- and GRP-cognate receptors, has no effect on phase delays of circadian rhythms induced by little SAAS. Conclusions/Significance Little SAAS relays signals downstream of light/glutamatergic signaling from eye to SCN, and independent of VIP and GRP action. These findings suggest that little SAAS forms a third SCN neuropeptidergic system, processing light information and activating phase-shifts within novel circuits of the central circadian clock. PMID:20830308

  5. 24 CFR 3282.309 - Formal and informal presentations of views held by SAAs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Formal and informal presentations of views held by SAAs. 3282.309 Section 3282.309 Housing and Urban Development Regulations Relating... held by SAAs. (a) When an SAA is the appropriate agency to hold a Formal or Informal Presentation of...

  6. Antioxidants inhibit SAA formation and pro-inflammatory cytokine release in a human cell model of alkaptonuria.

    PubMed

    Spreafico, Adriano; Millucci, Lia; Ghezzi, Lorenzo; Geminiani, Michela; Braconi, Daniela; Amato, Loredana; Chellini, Federico; Frediani, Bruno; Moretti, Elena; Collodel, Giulia; Bernardini, Giulia; Santucci, Annalisa

    2013-09-01

    Alkaptonuria (AKU) is an ultra-rare autosomal recessive disease that currently lacks an appropriate therapy. Recently we provided experimental evidence that AKU is a secondary serum amyloid A (SAA)-based amyloidosis. The aim of the present work was to evaluate the use of antioxidants to inhibit SAA amyloid and pro-inflammatory cytokine release in AKU. We adopted a human chondrocytic cell AKU model to evaluate the anti-amyloid capacity of a set of antioxidants that had previously been shown to counteract ochronosis in a serum AKU model. Amyloid presence was evaluated by Congo red staining. Homogentisic acid-induced SAA production and pro-inflammatory cytokine release (overexpressed in AKU patients) were evaluated by ELISA and multiplex systems, respectively. Lipid peroxidation was evaluated by means of a fluorescence-based assay. Our AKU model allowed us to prove the efficacy of ascorbic acid combined with N-acetylcysteine, taurine, phytic acid and lipoic acid in significantly inhibiting SAA production, pro-inflammatory cytokine release and membrane lipid peroxidation. All the tested antioxidant compounds were able to reduce the production of amyloid and may be the basis for establishing new therapies for AKU amyloidosis.

  7. Antioxidants inhibit SAA formation and pro-inflammatory cytokine release in a human cell model of alkaptonuria

    PubMed Central

    Spreafico, Adriano; Millucci, Lia; Ghezzi, Lorenzo; Geminiani, Michela; Braconi, Daniela; Amato, Loredana; Chellini, Federico; Frediani, Bruno; Moretti, Elena; Collodel, Giulia; Bernardini, Giulia

    2013-01-01

    Objective. Alkaptonuria (AKU) is an ultra-rare autosomal recessive disease that currently lacks an appropriate therapy. Recently we provided experimental evidence that AKU is a secondary serum amyloid A (SAA)-based amyloidosis. The aim of the present work was to evaluate the use of antioxidants to inhibit SAA amyloid and pro-inflammatory cytokine release in AKU. Methods. We adopted a human chondrocytic cell AKU model to evaluate the anti-amyloid capacity of a set of antioxidants that had previously been shown to counteract ochronosis in a serum AKU model. Amyloid presence was evaluated by Congo red staining. Homogentisic acid-induced SAA production and pro-inflammatory cytokine release (overexpressed in AKU patients) were evaluated by ELISA and multiplex systems, respectively. Lipid peroxidation was evaluated by means of a fluorescence-based assay. Results. Our AKU model allowed us to prove the efficacy of ascorbic acid combined with N-acetylcysteine, taurine, phytic acid and lipoic acid in significantly inhibiting SAA production, pro-inflammatory cytokine release and membrane lipid peroxidation. Conclusion. All the tested antioxidant compounds were able to reduce the production of amyloid and may be the basis for establishing new therapies for AKU amyloidosis. PMID:23704321

  8. A Novel Method for Mining SaaS Software Tag via Community Detection in Software Services Network

    NASA Astrophysics Data System (ADS)

    Qin, Li; Li, Bing; Pan, Wei-Feng; Peng, Tao

    The number of online software services based on SaaS paradigm is increasing. However, users usually find it hard to get the exact software services they need. At present, tags are widely used to annotate specific software services and also to facilitate the searching of them. Currently these tags are arbitrary and ambiguous since mostly of them are generated manually by service developers. This paper proposes a method for mining tags from the help documents of software services. By extracting terms from the help documents and calculating the similarity between the terms, we construct a software similarity network where nodes represent software services, edges denote the similarity relationship between software services, and the weights of the edges are the similarity degrees. The hierarchical clustering algorithm is used for community detection in this software similarity network. At the final stage, tags are mined for each of the communities and stored as ontology.

  9. Development of a SaaS application probe to the physical properties of the Earth's interior: An attempt at moving HPC to the cloud

    NASA Astrophysics Data System (ADS)

    Huang, Qian

    2014-09-01

    Scientific computing often requires the availability of a massive number of computers for performing large-scale simulations, and computing in mineral physics is no exception. In order to investigate physical properties of minerals at extreme conditions in computational mineral physics, parallel computing technology is used to speed up the performance by utilizing multiple computer resources to process a computational task simultaneously thereby greatly reducing computation time. Traditionally, parallel computing has been addressed by using High Performance Computing (HPC) solutions and installed facilities such as clusters and super computers. Today, it has been seen that there is a tremendous growth in cloud computing. Infrastructure as a Service (IaaS), the on-demand and pay-as-you-go model, creates a flexible and cost-effective mean to access computing resources. In this paper, a feasibility report of HPC on a cloud infrastructure is presented. It is found that current cloud services in IaaS layer still need to improve performance to be useful to research projects. On the other hand, Software as a Service (SaaS), another type of cloud computing, is introduced into an HPC system for computing in mineral physics, and an application of which is developed. In this paper, an overall description of this SaaS application is presented. This contribution can promote cloud application development in computational mineral physics, and cross-disciplinary studies.

  10. SAA drives proinflammatory heterotypic macrophage differentiation in the lung via CSF-1R-dependent signaling

    PubMed Central

    Anthony, Desiree; McQualter, Jonathan L.; Bishara, Maria; Lim, Ee X.; Yatmaz, Selcuk; Seow, Huei Jiunn; Hansen, Michelle; Thompson, Michelle; Hamilton, John A.; Irving, Louis B.; Levy, Bruce D.; Vlahos, Ross; Anderson, Gary P.; Bozinovski, Steven

    2014-01-01

    Serum amyloid A (SAA) is expressed locally in chronic inflammatory conditions such as chronic obstructive pulmonary disease (COPD), where macrophages that do not accord with the classic M1/M2 paradigm also accumulate. In this study, the role of SAA in regulating macrophage differentiation was investigated in vitro using human blood monocytes from healthy subjects and patients with COPD and in vivo using an airway SAA challenge model in BALB/c mice. Differentiation of human monocytes with SAA stimulated the proinflammatory monokines IL-6 and IL-1β concurrently with the M2 markers CD163 and IL-10. Furthermore, SAA-differentiated macrophages stimulated with lipopolysaccharide (LPS) expressed markedly higher levels of IL-6 and IL-1β. The ALX/FPR2 antagonist WRW4 reduced IL-6 and IL-1β expression but did not significantly inhibit phagocytic and efferocytic activity. In vivo, SAA administration induced the development of a CD11chighCD11bhigh macrophage population that generated higher levels of IL-6, IL-1β, and G-CSF following ex vivo LPS challenge. Blocking CSF-1R signaling effectively reduced the number of CD11chighCD11bhigh macrophages by 71% and also markedly inhibited neutrophilic inflammation by 80%. In conclusion, our findings suggest that SAA can promote a distinct CD11chighCD11bhigh macrophage phenotype, and targeting this population may provide a novel approach to treating chronic inflammatory conditions associated with persistent SAA expression.—Anthony, D., McQualter, J. L., Bishara, M., Lim, E. X., Yatmaz, S., Seow, H. J., Hansen, M., Thompson, M., Hamilton, J. A., Irving, L. B., Levy, B. D., Vlahos, R., Anderson, G. P., Bozinovski, S. SAA drives proinflammatory heterotypic macrophage differentiation in the lung via CSF-1R-dependent signaling. PMID:24846388

  11. The first molluscan acute phase serum amyloid A (A-SAA) identified from oyster Crassostrea hongkongensis: molecular cloning and functional characterization.

    PubMed

    Qu, Fufa; Xiang, Zhiming; Yu, Ziniu

    2014-08-01

    Serum amyloid A (SAA), a major evolutionarily conserved acute-phase protein, participates in many biological processes in eukaryotic cells, including innate immunity. However, little information regarding the relationship between SAA and innate immunity in mollusks is currently available. In this report, the first bivalve SAA (referred to as ChSAA) gene was identified and characterized from the Hong Kong oyster Crassostrea hongkongensis. Its full-length cDNA is 623 bp, including a 5'-UTR of 147 bp, a 3'-UTR of 56 bp containing a poly(A) tail and an open reading frame (ORF) of 420 bp that encodes a polypeptide of 139 amino acids. The predicted amino acid sequence of ChSAA comprises characteristic motifs of the SAA family, including a typical signal peptide and a conserved SAA domain. Comparison and phylogenetic analyses suggested that ChSAA shares a high identity to known acute-phase SAA proteins (A-SAAs). In addition, quantitative real-time PCR analysis revealed that ChSAA is constitutively expressed in all tissues examined, with the highest expression level in the mantle, and that its expression was acutely and significantly up-regulated in hemocytes following challenge by Vibrio alginolyticus (G(-)), Staphylococcus haemolyticus (G(+)) or Saccharomyces cerevisiae (fungus). Furthermore, over-expression of ChSAA via transfection with a ChSAA expression vector led to significantly increased NF-κB activity in HEK293T cells. These results suggest that ChSAA is likely to constitute a member of the A-SAA family involved in anti-pathogen responses in C. hongkongensis. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Space Shuttle drops down the SAA doses on ISS

    NASA Astrophysics Data System (ADS)

    Dachev, T. P.; Semkova, J.; Tomov, B.; Matviichuk, Yu.; Dimitrov, Pl.; Koleva, R.; Malchev, St.; Reitz, G.; Horneck, G.; De Angelis, G.; Häder, D.-P.; Petrov, V.; Shurshakov, V.; Benghin, V.; Chernykh, I.; Drobyshev, S.; Bankov, N. G.

    2011-06-01

    Long-term analysis of data from two radiation detection instruments on the International Space Station (ISS) shows that the docking of the Space Shuttle drops down the measured dose rates in the region of the South Atlantic Anomaly (SAA) by a factor of 1.5-3. Measurements either by the R3DE detector, which is outside the ISS at the EuTEF facility on the Columbus module behind a shielding of less than 0.45 g cm -2, and by the three detectors of the Liulin-5 particle telescope, which is inside the Russian PEARS module in the spherical tissue equivalent phantom behind much heavier shielding demonstrate that effect. Simultaneously the estimated averaged incident energies of the incoming protons rise up from about 30 to 45 MeV. The effect is explained by the additional shielding against the SAA 30-150 MeV protons, provided by the 78 tons Shuttle to the instruments inside and outside of the ISS. An additional reason is the ISS attitude change (performed for the Shuttle docking) leading to decreasing of dose rates in two of Liulin-5 detectors because of the East-West proton fluxes asymmetry in SAA. The Galactic Cosmic Rays dose rates are practically not affected.

  13. Extending multi-tenant architectures: a database model for a multi-target support in SaaS applications

    NASA Astrophysics Data System (ADS)

    Rico, Antonio; Noguera, Manuel; Garrido, José Luis; Benghazi, Kawtar; Barjis, Joseph

    2016-05-01

    Multi-tenant architectures (MTAs) are considered a cornerstone in the success of Software as a Service as a new application distribution formula. Multi-tenancy allows multiple customers (i.e. tenants) to be consolidated into the same operational system. This way, tenants run and share the same application instance as well as costs, which are significantly reduced. Functional needs vary from one tenant to another; either companies from different sectors run different types of applications or, although deploying the same functionality, they do differ in the extent of their complexity. In any case, MTA leaves one major concern regarding the companies' data, their privacy and security, which requires special attention to the data layer. In this article, we propose an extended data model that enhances traditional MTAs in respect of this concern. This extension - called multi-target - allows MT applications to host, manage and serve multiple functionalities within the same multi-tenant (MT) environment. The practical deployment of this approach will allow SaaS vendors to target multiple markets or address different levels of functional complexity and yet commercialise just one single MT application. The applicability of the approach is demonstrated via a case study of a real multi-tenancy multi-target (MT2) implementation, called Globalgest.

  14. Pathogenic Serum Amyloid A 1.1 Shows a Long Oligomer-rich Fibrillation Lag Phase Contrary to the Highly Amyloidogenic Non-pathogenic SAA2.2*

    PubMed Central

    Srinivasan, Saipraveen; Patke, Sanket; Wang, Yun; Ye, Zhuqiu; Litt, Jeffrey; Srivastava, Sunit K.; Lopez, Maria M.; Kurouski, Dmitry; Lednev, Igor K.; Kane, Ravi S.; Colón, Wilfredo

    2013-01-01

    Serum amyloid A (SAA) is best known for being the main component of amyloid in the inflammation-related disease amyloid A (AA) amyloidosis. Despite the high sequence identity among different SAA isoforms, not all SAA proteins are pathogenic. In most mouse strains, the AA deposits mostly consist of SAA1.1. Conversely, the CE/J type mouse expresses a single non-pathogenic SAA2.2 protein that is 94% identical to SAA1.1. Here we show that SAA1.1 and SAA2.2 differ in their quaternary structure, fibrillation kinetics, prefibrillar oligomers, and fibril morphology. At 37 °C and inflammation-related SAA concentrations, SAA1.1 exhibits an oligomer-rich fibrillation lag phase of a few days, whereas SAA2.2 shows virtually no lag phase and forms small fibrils within a few hours. Deep UV resonance Raman, far UV-circular dichroism, atomic force microscopy, and fibrillation cross-seeding experiments suggest that SAA1.1 and SAA2.2 fibrils possess different morphology. Both the long-lived oligomers of pathogenic SAA1.1 and the fleeting prefibrillar oligomers of non-pathogenic SAA2.2, but not their respective amyloid fibrils, permeabilized synthetic bilayer membranes in vitro. This study represents the first comprehensive comparison between the biophysical properties of SAA isoforms with distinct pathogenicities, and the results suggest that structural and kinetic differences in the oligomerization-fibrillation of SAA1.1 and SAA2.2, more than their intrinsic amyloidogenicity, may contribute to their diverse pathogenicity. PMID:23223242

  15. Comparable survival using a CMV-matched or a mismatched donor for CMV+ patients undergoing T-replete haplo-HSCT with PT-Cy for acute leukemia: a study of behalf of the infectious diseases and acute leukemia working parties of the EBMT.

    PubMed

    Cesaro, Simone; Crocchiolo, Roberto; Tridello, Gloria; Knelange, Nina; Van Lint, Maria Teresa; Koc, Yener; Ciceri, Fabio; Gülbas, Zafer; Tischer, Johanna; Afanasyev, Boris; Bruno, Benedetto; Castagna, Luca; Blaise, Didier; Mohty, Mohamad; Irrera, Giuseppe; Diez-Martin, J L; Pierelli, Luca; Pioltelli, Pietro; Arat, Mutlu; Delia, Mario; Fagioli, Franca; Ehninger, Gerhard; Aljurf, Mahmoud; Carella, Angelo Michele; Ozdogu, Hakan; Mikulska, Malgorzata; Ljungman, Per; Nagler, Arnon; Styczynski, Jan

    2018-04-01

    The role of donor CMV serostatus in the setting of non T-cell depleted haplo-HSCT with post-transplant cyclophosphamide (PT-Cy) has not been specifically addressed so far. Here we analyzed the impact of the donor CMV serological status on the outcome of 983 CMV seropositive (CMV+), acute leukemia patients receiving a first, non T-cell depleted haplo-HSCT registered in the EBMT database. The 1-year NRM was 21.3% (95% CI: 18.4-24.8) and 18.8% (95% CI: 13.8-25.5) in the CMV D+/R+ and D-/R+ pairs, respectively (p = 0.40). Similarly, 1-year OS was 55.1% (95% CI: 50.1-58.0) and 55.7% (95% CI: 48.0-62.8) in the same groups (p = 0.50). The other main outcomes were comparable. No difference in NRM nor OS was observed after stratification for the intensity of conditioning and multivariate anaysis confirmed the lack of significant association with NRM or OS. In conclusion, the choice of a CMV-seronegative donor did not impair early survival of CMV-seropositive patients with acute leukemia after a first, non T-cell depleted haploidentical HSCT and PT-Cy among this series of 983 consecutive patients. Future research may focus on the assessment of the hierarchy of all the donor variables.

  16. Working Party on International Nuclear Data Evaluation Cooperation (WPEC)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dupont, E., E-mail: wpec@oecd-nea.org; Chadwick, M.B.; Danon, Y.

    The OECD Nuclear Energy Agency (NEA) organizes cooperation between the major nuclear data evaluation projects in the world. The NEA Working Party on International Nuclear Data Evaluation Cooperation (WPEC) was established to promote the exchange of information on nuclear data evaluation, measurement, nuclear model calculation, validation, and related topics, and to provide a framework for cooperative activities between the participating projects. The working party assesses nuclear data improvement needs and addresses these needs by initiating joint activities in the framework of dedicated WPEC subgroups. Studies recently completed comprise a number of works related to nuclear data covariance and associated processingmore » issues, as well as more specific studies related to the resonance parameter representation in the unresolved resonance region, the gamma production from fission product capture reactions, the {sup 235}U capture cross section, the EXFOR database, and the improvement of nuclear data for advanced reactor systems. Ongoing activities focus on the evaluation of {sup 239}Pu in the resonance region, scattering angular distribution in the fast energy range, and reporting/usage of experimental data for evaluation in the resolved resonance region. New activities include two subgroups on improved fission product yield evaluation methodologies and on modern nuclear database structures. Future activities under discussion include a pilot project for a Collaborative International Evaluated Library Organization (CIELO) and methods to provide feedback from nuclear and covariance data adjustment for improvement of nuclear data. In addition to the above mentioned short-term task-oriented subgroups, WPEC also hosts a longer-term subgroup charged with reviewing and compiling the most important nuclear data requirements in a high priority request list (HPRL)« less

  17. Working Party on International Nuclear Data Evaluation Cooperation (WPEC)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Giuseppe Palmiotti

    The OECD Nuclear Energy Agency (NEA) is organizing the cooperation between the major nuclear data evaluation projects in the world. The NEA Working Party on International Nuclear Data Evaluation Cooperation (WPEC) was established to promote the exchange of information on nuclear data evaluation, measurement, nuclear model calculation, validation, and related topics, and to provide a framework for cooperative activities between the participating projects. The working party assesses nuclear data improvement needs and addresses these needs by initiating joint activities in the framework of dedicated WPEC subgroups. Studies recently completed comprise a number of works related to nuclear data covariance andmore » associated processing issues, as well as more specific studies related to the resonance parameter representation in the unresolved resonance region, the gamma production from fission-product capture reactions, the U-235 capture cross-section, the EXFOR database, and the improvement of nuclear data for advanced reactor systems. Ongoing activities focus on the evaluation of Pu-239 in the resonance region, scattering angular distribution in the fast energy range, and reporting/usage of experimental data for evaluation in the resolved resonance region. New activities include two new subgroups on improved fission product yield evaluation methodologies and on modern nuclear database structures. Future activities under discussion include a pilot project of a Collaborative International Evaluated Library (CIELO) and methods to provide feedback from nuclear and covariance data adjustment for improvement of nuclear data. In addition to the above mentioned short-term, task-oriented subgroups, the WPEC also hosts a longer-term subgroup charged with reviewing and compiling the most important nuclear data requirements in a high priority request list (HPRL).« less

  18. Working Party on International Nuclear Data Evaluation Cooperation (WPEC)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dupont, E.; Herman, M.; Dupont, E.

    The OECD Nuclear Energy Agency (NEA) organizes cooperation between the major nuclear data evaluation projects in the world. Moreover, the NEA Working Party on International Nuclear Data Evaluation Cooperation (WPEC) was established to promote the exchange of information on nuclear data evaluation, measurement, nuclear model calculation, validation, and related topics, and to provide a framework for cooperative activities between the participating projects. The working party assesses nuclear data improvement needs and addresses these needs by initiating joint activities in the framework of dedicated WPEC subgroups. Studies recently completed comprise a number of works related to nuclear data covariance and associatedmore » processing issues, as well as more specific studies related to the resonance parameter representation in the unresolved resonance region, the gamma production from fission product capture reactions, the 235U capture cross section, the EXFOR database, and the improvement of nuclear data for advanced reactor systems. Ongoing activities focus on the evaluation of 239Pu in the resonance region, scattering angular distribution in the fast energy range, and reporting/usage of experimental data for evaluation in the resolved resonance region. New activities include two subgroups on improved fission product yield evaluation methodologies and on modern nuclear database structures. Some future activities under discussion include a pilot project for a Collaborative International Evaluated Library Organization (CIELO) and methods to provide feedback from nuclear and covariance data adjustment for improvement of nuclear data. In addition to the above mentioned short-term task-oriented subgroups, WPEC also hosts a longer-term subgroup charged with reviewing and compiling the most important nuclear data requirements in a high priority request list (HPRL).« less

  19. ‘To quarterback behind the scenes, third-party efforts’: the tobacco industry and the Tea Party

    PubMed Central

    Fallin, Amanda; Grana, Rachel; Glantz, Stanton A

    2014-01-01

    Background The Tea Party, which gained prominence in the USA in 2009, advocates limited government and low taxes. Tea Party organisations, particularly Americans for Prosperity and FreedomWorks, oppose smoke-free laws and tobacco taxes. Methods We used the Legacy Tobacco Documents Library, the Wayback Machine, Google, LexisNexis, the Center for Media and Democracy and the Center for Responsive Politics (opensecrets.org) to examine the tobacco companies’ connections to the Tea Party. Results Starting in the 1980s, tobacco companies worked to create the appearance of broad opposition to tobacco control policies by attempting to create a grassroots smokers’ rights movement. Simultaneously, they funded and worked through third-party groups, such as Citizens for a Sound Economy, the predecessor of AFP and FreedomWorks, to accomplish their economic and political agenda. There has been continuity of some key players, strategies and messages from these groups to Tea Party organisations. As of 2012, the Tea Party was beginning to spread internationally. Conclusions Rather than being a purely grassroots movement that spontaneously developed in 2009, the Tea Party has developed over time, in part through decades of work by the tobacco industry and other corporate interests. It is important for tobacco control advocates in the USA and internationally, to anticipate and counter Tea Party opposition to tobacco control policies and ensure that policymakers, the media and the public understand the longstanding connection between the tobacco industry, the Tea Party and its associated organisations. PMID:23396417

  20. 'To quarterback behind the scenes, third-party efforts': the tobacco industry and the Tea Party.

    PubMed

    Fallin, Amanda; Grana, Rachel; Glantz, Stanton A

    2014-07-01

    The Tea Party, which gained prominence in the USA in 2009, advocates limited government and low taxes. Tea Party organisations, particularly Americans for Prosperity and FreedomWorks, oppose smoke-free laws and tobacco taxes. We used the Legacy Tobacco Documents Library, the Wayback Machine, Google, LexisNexis, the Center for Media and Democracy and the Center for Responsive Politics (opensecrets.org) to examine the tobacco companies' connections to the Tea Party. Starting in the 1980s, tobacco companies worked to create the appearance of broad opposition to tobacco control policies by attempting to create a grassroots smokers' rights movement. Simultaneously, they funded and worked through third-party groups, such as Citizens for a Sound Economy, the predecessor of AFP and FreedomWorks, to accomplish their economic and political agenda. There has been continuity of some key players, strategies and messages from these groups to Tea Party organisations. As of 2012, the Tea Party was beginning to spread internationally. Rather than being a purely grassroots movement that spontaneously developed in 2009, the Tea Party has developed over time, in part through decades of work by the tobacco industry and other corporate interests. It is important for tobacco control advocates in the USA and internationally, to anticipate and counter Tea Party opposition to tobacco control policies and ensure that policymakers, the media and the public understand the longstanding connection between the tobacco industry, the Tea Party and its associated organisations. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  1. Associations of SAA1 gene polymorphism with lipid lelvels and osteoporosis in Chinese women.

    PubMed

    Feng, Zheng-Ping; Li, Xiao-Yu; Jiang, Rong; Deng, Hua-Cong; Yang, Mei; Zhou, Qin; Que, Wen-Jun; Du, Jia

    2013-03-22

    The development of osteoporosis is associated with several risk factors, such as genetic polymorphisms and enviromental factors. This study assessed the correlation between SAA1 gene rs12218 polymorphism and HDL-C lelvels and osteoporosis in a population of Chinese women. A total of 387 postmenopausal female patients who were diagnosed with osteoporosis (case group) based on bone mineral density measurements via dual-energy x-ray absorptiometry and 307 females with no osteoporosis (control group) were included in this study. Correlations between SAA1 gene rs12218 polymorphism and osteoporosis and HDL-C level were investigated through the identification of SAA1 gene rs12218 polymorphism genotypes using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The TT genotype of rs12218 was more frequently in osteoporosis patients than in control subjects (P <0.001). And the rs12218 was found to be associated with plasma TG, HDL-C, LDL-C, and BMD levels in osteoporosis patients (P<0.05). The present results indicate that both osteoporosis and lipids levels are associated with the TT genotype of rs12218 in the human SAA1 gene.

  2. Associations of SAA1 gene polymorphism with Lipid lelvels and osteoporosis in Chinese women

    PubMed Central

    2013-01-01

    Background The development of osteoporosis is associated with several risk factors, such as genetic polymorphisms and enviromental factors. This study assessed the correlation between SAA1 gene rs12218 polymorphism and HDL-C lelvels and osteoporosis in a population of Chinese women. Methods A total of 387 postmenopausal female patients who were diagnosed with osteoporosis (case group) based on bone mineral density measurements via dual-energy x-ray absorptiometry and 307 females with no osteoporosis (control group) were included in this study. Correlations between SAA1 gene rs12218 polymorphism and osteoporosis and HDL-C level were investigated through the identification of SAA1 gene rs12218 polymorphism genotypes using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The TT genotype of rs12218 was more frequently in osteoporosis patients than in control subjects (P <0.001). And the rs12218 was found to be associated with plasma TG, HDL-C, LDL-C, and BMD levels in osteoporosis patients (P<0.05). Conclusions The present results indicate that both osteoporosis and lipids levels are associated with the TT genotype of rs12218 in the human SAA1 gene. PMID:23522429

  3. Long term impact of hyperleukocytosis in newly diagnosed acute myeloid leukemia patients undergoing allogeneic stem cell transplantation: An analysis from the acute leukemia working party of the EBMT.

    PubMed

    Canaani, Jonathan; Labopin, Myriam; Socié, Gerard; Nihtinen, Anne; Huynh, Anne; Cornelissen, Jan; Deconinck, Eric; Gedde-Dahl, Tobias; Forcade, Edouard; Chevallier, Patrice; Bourhis, Jean H; Blaise, Didier; Mohty, Mohamad; Nagler, Arnon

    2017-07-01

    Up to 20% of acute myeloid leukemia (AML) patients present initially with hyperleukocytosis, placing them at increased risk for early mortality during induction. Yet, it is unknown whether hyperleukocytosis still retains prognostic value for AML patients undergoing hematopoietic stem cell transplantation (HSCT). Furthermore, it is unknown whether hyperleukocytosis holds prognostic significance when modern molecular markers such as FLT3-ITD and NPM1 are accounted for. To determine whether hyperleukocytosis is an independent prognostic factor influencing outcome in transplanted AML patients we performed a retrospective analysis using the registry of the acute leukemia working party of the European Society of Blood and Marrow Transplantation. A cohort of 357 patients with hyperleukocytosis (159 patients with white blood count [WBC] 50 K-100 K, 198 patients with WBC ≥ 100 K) was compared to 918 patients without hyperleukocytosis. Patients with hyperleukocytosis were younger, had an increased rate of favorable risk cytogenetics, and more likely to be FLT3 and NPM1 mutated. In multivariate analysis, hyperleukocytosis was independently associated with increased relapse incidence (hazard ratio [HR] of 1.55, 95% confidence interval [CI], 1.14-2.12; P = .004), decreased leukemia-free survival (HR of 1.38, 95% CI, 1.07-1.78; P = .013), and inferior overall survival (HR of 1.4, 95% CI, 1.07-1.84; P = .013). Hyperleukocytosis retains a significant prognostic role for AML patients undergoing HSCT. © 2017 Wiley Periodicals, Inc.

  4. Getting SaaS-y. Why the sisters of Mercy Health System opted for on-demand portfolio management.

    PubMed

    Carter, Jay

    2011-03-01

    Sisters of Mercy Health System chose the SaaS model as a simpler way to plan, execute, and monitor strategic business initiatives. It also provided something that was easy to use and offered quick time to value.

  5. [The advantages of a third party in the “work organization” of head nurses.

    PubMed

    Dujardin, Pierre-Philippe; Valette, Annick; Reverdy, Thomas; François, Patrice

    The organisation of production of care is a task that requires three different levels of competence: operational, structural and learning skills. The organisational requirements (OR) of the Head Nurse (HN) are often centered on the operational level, to the detriment of the other two levels. This difficulty is due to the organisation which presents limited political, cognitive and pragmatic levels of rationality.The aim of this study was to identify the impact of a third party in relation to the organisation and its effect on the HN's OR. An educational device places HN students in the position of a third party to allow them to work on an organisational problem delegated by a HN. The research-intervention followed 17 projects over a period of one year.Intervention by a third party legitimised the problem by recognizing the difficulties in nursing and reconfiguring relations between healthcare professionals in a political dimension. The methods employed by the third party reassured the HN and completed their knowledge, placing particular focus on the importance of methodology and managerial posture. In practice, the third party supported the HN's power to act and coordinate the various members of the team. The third party contributes to the development of the HN's OR and completes certain limits of the HN's rationality. Nevertheless, difficulties still remain in the development of practices outside the medical team, limiting the extension to other services.A unit managerial support, a collective schedule and open spaces of discussion are recommended to bring structure and support to the OR.

  6. Thiotepa-based conditioning versus total body irradiation as myeloablative conditioning prior to allogeneic stem cell transplantation for acute lymphoblastic leukemia: A matched-pair analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.

    PubMed

    Eder, Sandra; Canaani, Jonathan; Beohou, Eric; Labopin, Myriam; Sanz, Jaime; Arcese, William; Or, Reuven; Finke, Juergen; Cortelezzi, Agostino; Beelen, Dietrich; Passweg, Jakob; Socié, Gerard; Gurman, Gunhan; Aljurf, Mahmoud; Stelljes, Matthias; Giebel, Sebastian; Mohty, Mohamad; Nagler, Arnon

    2017-10-01

    The optimal conditioning regimen to employ before hematopoietic stem cell transplantation in acute lymphoblastic leukemia (ALL) is still undecided, and while cyclophosphamide/total body irradiation (Cy/TBI) is the most commonly used myeloablative regimen, there are concerns regarding long-term toxicity for patients conditioned with this regimen. Thiotepa-based conditioning is an emerging radiation-free regimen with recent publications indicative of comparable clinical outcomes to TBI-based conditioning. In this analysis of the acute leukemia working party of the EBMT, we performed a retrospective matched-pair analysis, evaluating the outcome of adult patients with ALL who received thiotepa-based conditioning (n = 180) with those receiving Cy/TBI conditioning (n = 540). The 2-year leukemia-free survival and overall survival (OS) rates of both conditioning regimens were comparable, 33% for thiotepa [95% confidence interval (CI): 26.4-42.8] versus 39% for Cy/TBI (95% CI: 34.8-44.5] (P = .33) and 46.5% [95% CI: 38.6-56.1] versus 48.8% [95% CI: 44.2-54] (P = .9), respectively. There was no significant difference between the two regimens in the incidence of either acute graft versus host disease (GVHD) or chronic GVHD. Multivariate analysis demonstrated increased relapse incidence for thiotepa conditioning compared to Cy/TBI (HR = 1.78, 95% CI, 1.07-2.95; P = .03) which did not affect OS. Our results indicate that thiotepa-based conditioning may not be inferior to Cy/TBI for adult patients with ALL. © 2017 Wiley Periodicals, Inc.

  7. Allogeneic stem cell transplantation in adult patients with acute myeloid leukaemia and 17p abnormalities in first complete remission: a study from the Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT).

    PubMed

    Poiré, Xavier; Labopin, Myriam; Maertens, Johan; Yakoub-Agha, Ibrahim; Blaise, Didier; Ifrah, Norbert; Socié, Gérard; Gedde-Dhal, Tobias; Schaap, Nicolaas; Cornelissen, Jan J; Vigouroux, Stéphane; Sanz, Jaime; Michaux, Lucienne; Esteve, Jordi; Mohty, Mohamad; Nagler, Arnon

    2017-01-18

    Acute myeloid leukaemia (AML) with 17p abnormalities (abn(17p)) carries a very poor prognosis due to high refractoriness to conventional chemotherapy, and allogeneic stem cell transplantation (allo-SCT) appears as the only potential curative option. To address outcomes after allo-SCT in patients with abn(17p), we retrospectively analysed de novo or secondary AML undergoing SCT between 2000 and 2013 from the EBMT registry. One hundred thirty-nine patients with confirmed abn(17p) have been selected. At the time of transplant, one hundred twenty-five were in first remission (CR1). Median age was 54 years old. Abn(17p) was associated with a monosomal karyotype in 83% of patients, complex karyotype in 91%, monosomy 5 or 5q deletion (-5/5q-) in 55%, monosomy 7 (-7) in 39% and both -5/5q and -7 in 27%. Seventy-three patients (59%) had a reduced-intensity conditioning regimen. The 2-year overall survival (OS) and leukaemia-free survival (LFS) were 28 and 24%, respectively. The 2-year non-relapse mortality (NRM) was 15%, and 2-year relapse incidence (RI) was 61%. The cumulative incidence of grade II to IV acute graft-versus-host disease (GvHD) was 24% and that of chronic GvHD was 21%. In multivariate analysis, the presence of a -5/5q- in addition to abn(17p) was significantly and independently associated with worse OS, LFS and higher RI. Age and donor types did not correlate with outcome. Conditioning intensity was not statistically associated with OS, LFS and NRM when adjusted for patients' age. In contrast to the dismal prognosis reported for AML patients harbouring abn(17p) undergoing conventional chemotherapy, allogeneic SCT provides responses in about 25% of those patients transplanted in CR1.

  8. The ectoenzyme-side of matrix metalloproteinases (MMPs) makes inflammation by serum amyloid A (SAA) and chemokines go round.

    PubMed

    De Buck, Mieke; Gouwy, Mieke; Struyf, Sofie; Opdenakker, Ghislain; Van Damme, Jo

    2018-06-02

    During an inflammatory response, a large number of distinct mediators appears in the affected tissues or in the blood circulation. These include acute phase proteins such as serum amyloid A (SAA), cytokines and chemokines and proteolytic enzymes. Although these molecules are generated within a cascade sequence in specific body compartments allowing for independent action, their co-appearance in space and time during acute or chronic inflammation points toward important mutual interactions. Pathogen-associated molecular patterns lead to fast induction of the pro-inflammatory endogenous pyrogens, which are evoking the acute phase response. Interleukin-1, tumor necrosis factor-α and interferons simultaneously trigger different cell types, including leukocytes, endothelial cells and fibroblasts for tissue-specific or systemic production of chemokines and matrix metalloproteinases (MMPs). In addition, SAA induces chemokines and both stimulate secretion of MMPs from multiple cell types. As a consequence, these mediators may cooperate to enhance the inflammatory response. Indeed, SAA synergizes with chemokines to increase chemoattraction of monocytes and granulocytes. On the other hand, MMPs post-translationally modify chemokines and SAA to reduce their activity. Indeed, MMPs internally cleave SAA with loss of its cytokine-inducing and direct chemotactic potential whilst retaining its capacity to synergize with chemokines in leukocyte migration. Finally, MMPs truncate chemokines at their NH 2 - or COOH-terminal end, resulting in reduced or enhanced chemotactic activity. Therefore, the complex interactions between chemokines, SAA and MMPs either maintain or dampen the inflammatory response. Copyright © 2018. Published by Elsevier B.V.

  9. Proceedings, I.U.F.R.O. Beech Bark Disease Working Party Conference

    Treesearch

    Forest Service. U.S.

    1983-01-01

    This conference was the first full meeting of the Working Party since its inception at the Beech Bark Disease Colloquium held in Nancy, France in 1979. The meeting from 27 September to 7 October 1982 took the form of a study tour convened at the College of Forestry, University of Maine,with field trips in the Central New England States and New York and concluding at...

  10. Forty-Year "Drift" and Change of the SAA

    NASA Technical Reports Server (NTRS)

    Stassinopoulos, Epaminondas G,; Xapsos, Michael A.; Stauffer, Craig A.

    2015-01-01

    A comprehensive study was conducted to evaluate the change in the location and size of the South Atlantic Anomaly (SAA) as a function of time, primarily in relation to trapped Van Allen Belt proton populations. The study was limited to one altitude only (800 km), which is still within the Earth's atmosphere but is removed from the atmospheric cut-off level located at about 100-200 km.

  11. ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine.

    PubMed

    Berezniuk, Iryna; Rodriguiz, Ramona M; Zee, Michael L; Marcus, David J; Pintar, John; Morgan, Daniel J; Wetsel, William C; Fricker, Lloyd D

    2017-11-01

    To identify neuropeptides that are regulated by cocaine, we used a quantitative peptidomic technique to examine the relative levels of neuropeptides in several regions of mouse brain following daily intraperitoneal administration of 10 mg/kg cocaine or saline for 7 days. A total of 102 distinct peptides were identified in one or more of the following brain regions: nucleus accumbens, caudate putamen, frontal cortex, and ventral tegmental area. None of the peptides detected in the caudate putamen or frontal cortex were altered by cocaine administration. Three peptides in the nucleus accumbens and seven peptides in the ventral tegmental area were significantly decreased in cocaine-treated mice. Five of these ten peptides are derived from proSAAS, a secretory pathway protein and neuropeptide precursor. To investigate whether proSAAS peptides contribute to the physiological effects of psychostimulants, we examined acute responses to cocaine and amphetamine in the open field with wild-type (WT) and proSAAS knockout (KO) mice. Locomotion was stimulated more robustly in the WT compared to mutant mice for both psychostimulants. Behavioral sensitization to amphetamine was not maintained in proSAAS KO mice and these mutants failed to sensitize to cocaine. To determine whether the rewarding effects of cocaine were altered, mice were tested in conditioned place preference (CPP). Both WT and proSAAS KO mice showed dose-dependent CPP to cocaine that was not distinguished by genotype. Taken together, these results suggest that proSAAS-derived peptides contribute differentially to the behavioral sensitization to psychostimulants, while the rewarding effects of cocaine appear intact in mice lacking proSAAS. © 2017 International Society for Neurochemistry.

  12. Course of serum amyloid A (SAA) plasma concentrations in horses undergoing surgery for injuries penetrating synovial structures, an observational clinical study.

    PubMed

    Haltmayer, Eva; Schwendenwein, Ilse; Licka, Theresia F

    2017-05-22

    Injuries penetrating synovial structures are common in equine practice and often result in septic synovitis. Significantly increased plasma levels of serum amyloid A (SAA) have been found in various infectious conditions in horses including wounds and septic arthritis. Plasma SAA levels were found to decrease rapidly once the infectious stimulus was eliminated. The purpose of the current study was to investigate the usefulness of serial measurements of plasma SAA as a monitoring tool for the response to treatment of horses presented with injuries penetrating synovial structures. In the current study plasma SAA concentrations were measured every 48 hours (h) during the course of treatment. A total of 19 horses with a wound penetrating a synovial structure were included in the current study. Horses in Group 1 (n = 12) (injuries older than 24 h) only needed one surgical intervention. Patients in this group had significantly lower median plasma SAA levels (P = 0.001) between 48 h (median 776 mg/L) and 96 h (median 202 mg/L) after surgery. A significant decrease (P = 0.004) in plasma SAA levels was also observed between 96 h after surgery (median 270 mg/L) and 6 days (d) after surgery (median 3 mg/L). Four horses (Group 2) required more than one surgical intervention. In contrast to Group 1 patients in Group 2 had either very high initial plasma concentrations (3378 mg/L), an increase or persistently high concentrations of plasma SAA after the first surgery (median 2525 mg/L). A small group of patients (n = 3) (Group 3) were admitted less than 24 h after sustaining a wound. In this group low SAA values at admission (median 23 mg/L) and peak concentrations at 48 h after surgery (median 1016 mg/L) were observed followed by a decrease in plasma SAA concentration over time. A decrease in plasma SAA concentrations between two consecutive time points could be associated with positive response to treatment in the current study. Therefore, serial

  13. Management of Helicobacter pylori infection--a Working Party Report of the Malaysian Society of Gastroenterology and Hepatology.

    PubMed

    Goh, K L; Mahendra Raj, S; Parasakthi, N; Kew, S T; Kandasami, P; Mazlam, Z

    1998-09-01

    The Working Party Report on the Management of Helicobacter pylori serves as a clinical practice guideline for Malaysian doctors. H. pylori is not uncommon in the Malaysian population. Marked racial differences and the consistently low prevalence rates amongst Malays are noted. The working party recommends that if endoscopy is to be performed, a rapid urease test should be used for diagnosis. Where suspicion of the infection is strong and the urease test is negative, histology should be performed on gastric biopsies. Culture should be used to monitor resistance patterns to antibiotics and regional laboratories should assume this responsibility. The urea breath tests are highly accurate tests for diagnosis of H. pylori but is as yet not widely available in Malaysia. The working party strongly recommends that all peptic ulcer patients infected with H. pylori whether active, in remission and complicated ulcers should be treated for the infection. Patients with low-grade gastric mucosal lymphoid tissue lymphoma should also be treated for H. pylori infection. It is considered advisable that patients on long term nonsteroidal antinflammatory drug (NSAID) treatment with a history of peptic ulcers or dyspepsia and patients following resection of early gastric cancer or those with a family history of gastric cancer should also be tested and treated for H. pylori. The working party recommends, as first line treatment a 7-day combination therapy of a proton pump inhibitor, clarithromycin and metronidazole or amoxicillin. High metronidazole resistance rates locally may adversely affect regimens containing the antibiotic. It should also be noted that regimens that yield lower eradication rates may result in higher long term expenditure.

  14. Synthesis and conformational analysis of linear homo- and heterooligomers from novel 2-C-branched sugar amino acids (SAAs).

    PubMed

    Tian, Guang-Zong; Hu, Jing; Zhang, Heng-Xi; Rademacher, Christoph; Zou, Xiao-Peng; Zheng, Hong-Ning; Xu, Fei; Wang, Xiao-Li; Linker, Torsten; Yin, Jian

    2018-04-26

    Sugar amino acids (SAAs), as biologically interesting structures bearing both amino and carboxylic acid functional groups represent an important class of multifunctional building blocks. In this study, we develop an easy access to novel SAAs in only three steps starting from nitro compounds in high yields in analytically pure form, easily available by ceric (IV) mediated radical additions. Such novel SAAs have been applied in the assembly of total nine carbopeptoids with the form of linear homo- and heterooligomers for the structural investigations employing circular dichroism (CD) spectroscopy, which suggest that the carbopeptoids emerge a well-extended, left (or right)-handed conformation similar to polyproline II (PPII) helices. NMR studies also clearly demonstrated the presence of ordered secondary structural elements. 2D-ROESY spectra were acquired to identify i+1 NH ↔  i C 1 H, i C 2 H correlations which support the conformational analysis of tetramers by CD spectroscopy. These findings provide interesting information of SAAs and their oligomers as potential scaffolds for discovering new drugs and materials.

  15. UAS-NAS Live Virtual Constructive Distributed Environment (LVC): LVC Gateway, Gateway Toolbox, Gateway Data Logger (GDL), SaaProc Software Design Description

    NASA Technical Reports Server (NTRS)

    Jovic, Srboljub

    2015-01-01

    This document provides the software design description for the two core software components, the LVC Gateway, the LVC Gateway Toolbox, and two participants, the LVC Gateway Data Logger and the SAA Processor (SaaProc).

  16. The Generic Spacecraft Analyst Assistant (GenSAA): A tool for automating spacecraft monitoring with expert systems

    NASA Technical Reports Server (NTRS)

    Hughes, Peter M.; Luczak, Edward C.

    1991-01-01

    Flight Operations Analysts (FOAs) in the Payload Operations Control Center (POCC) are responsible for monitoring a satellite's health and safety. As satellites become more complex and data rates increase, FOAs are quickly approaching a level of information saturation. The FOAs in the spacecraft control center for the COBE (Cosmic Background Explorer) satellite are currently using a fault isolation expert system named the Communications Link Expert Assistance Resource (CLEAR), to assist in isolating and correcting communications link faults. Due to the success of CLEAR and several other systems in the control center domain, many other monitoring and fault isolation expert systems will likely be developed to support control center operations during the early 1990s. To facilitate the development of these systems, a project was initiated to develop a domain specific tool, named the Generic Spacecraft Analyst Assistant (GenSAA). GenSAA will enable spacecraft analysts to easily build simple real-time expert systems that perform spacecraft monitoring and fault isolation functions. Lessons learned during the development of several expert systems at Goddard, thereby establishing the foundation of GenSAA's objectives and offering insights in how problems may be avoided in future project, are described. This is followed by a description of the capabilities, architecture, and usage of GenSAA along with a discussion of its application to future NASA missions.

  17. EOP and SAA Undergraduates Who Left UC Davis without a Degree.

    ERIC Educational Resources Information Center

    Rasor, Marianne

    Undergraduate students enrolled in the Educational Opportunity Program (EOP) or the Student Affirmative Action (SAA) program at the University of California (UC), Davis, who withdrew before graduation were surveyed in 1981. Attention was directed to the respondents' educational experiences after leaving, their current employment, and their…

  18. EBMT transplant centers with FACT-JACIE accreditation have significantly better compliance with related donor care standards

    PubMed Central

    Anthias, Chloe; O'Donnell, Paul V; Kiefer, Deidre M; Yared, Jean; Norkin, Maxim; Anderlini, Paolo; Savani, Bipin N; Diaz, Miguel A; Bitan, Menachem; Halter, Joerg P; Logan, Brent R; Switzer, Galen E; Pulsipher, Michael A; Confer, Dennis L; Shaw, Bronwen E

    2016-01-01

    Previous studies have identified healthcare practices that may place undue pressure on related donors (RDs) of hematopoietic cell products, and an increase in serious adverse events associated with morbidities in this population. As a result, specific requirements to safeguard RD health have been introduced to FACT-JACIE Standards, but the impact of accreditation on RD care has not previously been evaluated. A survey of transplant program directors of EBMT member centers was conducted by the Donor Health and Safety Working Committee of the Center for International Blood and Marrow Transplant Research (CIBMTR) to test the hypothesis that RD care in FACT-JACIE accredited centers is more closely aligned with international consensus donor care recommendations than RD care delivered in centers without accreditation. Responses were received from 39% of 304 centers. Our results show that practice in accredited centers was much closer to recommended standards as compared to non-accredited centers. Specifically, a higher percentage of accredited centers use eligibility criteria to assess RDs (93% versus 78%; P=0.02) and a lower percentage have a single physician simultaneously responsible for a RD and their recipient (14% versus 35%; P=0.008). In contrast, where regulatory standards do not exist, both accredited and non-accredited centers fell short of accepted best practice. These results raise concerns that despite improvements in care, current practice can place undue pressure on donors, and may increase the risk of donation-associated adverse events. We recommend measures to address these issues through enhancement of regulatory standards as well as national initiatives to standardize RD care. PMID:26597079

  19. Validation of the EBMT risk score in chronic myeloid leukemia in Brazil and allogeneic transplant outcome.

    PubMed

    De Souza, Carmino Antonio; Vigorito, Afonso Celso; Ruiz, Milton Artur; Nucci, Márcio; Dulley, Frederico Luiz; Funcke, Vaneusa; Tabak, Daniel; Azevedo, Alexandre Mello; Byington, Rita; Macedo, Maria Cristina; Saboya, Rosaura; Penteado Aranha, Francisco José; Oliveira, Gislaine Barbosa; Zulli, Roberto; Martins Miranda, Eliana Cristina; Azevedo, Wellington Moraes; Lodi, Fernanda Maria; Voltarelli, Júlio Cesar; Simões, Belinda Pinto; Colturato, Vergílio; De Souza, Mair Pedro; Silla, Lúcia; Bittencourt, Henrique; Piron-Ruiz, Lilian; Maiolino, Angelo; Gratwohl, Alois; Pasquini, Ricardo

    2005-02-01

    The management of chronic myeloid leukemia (CML) has changed radically since the introduction of imatinib therapy. The decision of whether to offer a patient a hematopoietic stem cell transplant (HSCT) must be based on the probability of success of the procedure. The aim of this retrospective analysis of 1,084 CML patients who received an allogeneic HSCT in 10 Brazilian Centers between February 1983 and March 2003 was to validate the EBMT risk score. The study population comprised 647 (60%) males and 437 (40%) females, with a median age of 32 years old (range 1 - 59); 898 (83%) were in chronic phase, 146 (13%) were in accelerated phase and 40 (4%) were in blast crisis; 151 (14%) were younger than 20 years old, 620 (57%) were between 20 and 40 and 313 (29%) were older than 40; 1,025 (94%) received an HLA fully matched sibling transplant and only 59 (6%) received an unrelated transplant. In 283 cases (26%) a male recipient received a graft from a female donor. The interval from diagnosis to transplantation was less than 12 months in 223 (21%) cases and greater in 861 (79%). The overall survival, disease-free survival, transplant-related mortality and relapse incidence were 49%, 50%, 45% and 25%, respectively. Of the 1084 patients, 179 (17%) had a risk score of 0 or 1, 397 (37%) had a score of 2, 345 (32%) had a score of 3, 135 (12%) had a score of 4 and 28 (2%) a score of 5 or 6. The overall survival (OS) rate in patients with risk scores 0-1 and 2 was similar (58% and 55%, respectively) but significantly better than that in patients with scores 3 or more (score 3 - 44%, 4 - 36 % and 5-6 - 27%, respectively) pp<0.001). Disease-free survival (DFS) and transplant related mortality (TRM) in a patients with a score of 3 or more were 46% and 49%, respectively and the relapse rate beyond score 5-6 was 77%. Disease status had a negative impact on all outcomes (OS, DFS, TRM, and relapse). The OS rate for male recipients of a graft from a female donor was 40% compared to 52

  20. An eclogite-bearing continental tectonic slice in the Zermatt-Saas high-pressure ophiolites at Trockener Steg (Zermatt, Swiss Western Alps)

    NASA Astrophysics Data System (ADS)

    Weber, Sebastian; Bucher, Kurt

    2015-09-01

    The Theodul Glacier Unit (TGU) at "Trockener Steg" represents a continental slice, embedded within the ophiolitic Zermatt-Saas Zone. The Zermatt-Saas Zone is the remnant of the Piemonte-Liguria oceanic lithosphere, formed in the middle Jurassic and subducted up to eclogite facies conditions in the Early Tertiary. The close spatial association of the TGU to the Zermatt-Saas Zone permits a comparison of the metamorphic evolution of the units by detailed field mapping and a petrological investigation of eclogites. The eclogites from both tectono-metamorphic units can be clearly distinguished by their textures, mineral assemblages and by mineral and bulk-rock composition. Geothermobarometry and computed assemblage stability diagrams for the TGU eclogites indicate P-T conditions of 2.2 ± 0.1 GPa and 580 ± 50 °C. These derived P-T conditions must be considered as minimum peak metamorphic conditions the rocks achieved during subduction. The P-T data are different from those derived for eclogites of Zermatt-Saas Zone adjacent to the Theodul Glacier Unit, that reached maximal burial depths at 2.3-2.4 GPa and 500 ± 50 °C. While the estimates of the eclogites of Zermatt-Saas Zone are in good agreement with some of the previous studies, the contrasting P-T estimates for the TGU eclogites suggest that the Zermatt-Saas complex must be subdivided into several tectonic subunits. The non-uniform peak conditions over the "Trockener Steg" area and the maximum pressures conditions reported from ultra-high pressure localities within Zermatt-Saas Zone suggest, that individual tectonic slices have been assembled after detachment from the slab at the return-point, i.e. along the exhumation path. Detached packages of rocks may range from small tectonic slices up to several kilometer-sized fragments. The TGU is separated from the surrounding rocks of the ophiolite unit by two major tectonic contacts. In addition, the formation of biotite-rich crusts along the basal contact of the TGU

  1. flexCloud: Deployment of the FLEXPART Atmospheric Transport Model as a Cloud SaaS Environment

    NASA Astrophysics Data System (ADS)

    Morton, Don; Arnold, Dèlia

    2014-05-01

    FLEXPART (FLEXible PARTicle dispersion model) is a Lagrangian transport and dispersion model used by a growing international community. We have used it to simulate and forecast the atmospheric transport of wildfire smoke, volcanic ash and radionuclides. Additionally, FLEXPART may be run in backwards mode to provide information for the determination of emission sources such as nuclear emissions and greenhouse gases. This open source software is distributed in source code form, and has several compiler and library dependencies that users need to address. Although well-documented, getting it compiled, set up, running, and post-processed is often tedious, making it difficult for the inexperienced user. Our interest is in moving scientific modeling and simulation activities from site-specific clusters and supercomputers to a cloud model as a service paradigm. Choosing FLEXPART for our prototyping, our vision is to construct customised IaaS images containing fully-compiled and configured FLEXPART codes, including pre-processing, execution and postprocessing components. In addition, with the inclusion of a small web server in the image, we introduce a web-accessible graphical user interface that drives the system. A further initiative being pursued is the deployment of multiple, simultaneous FLEXPART ensembles in the cloud. A single front-end web interface is used to define the ensemble members, and separate cloud instances are launched, on-demand, to run the individual models and to conglomerate the outputs into a unified display. The outcome of this work is a Software as a Service (Saas) deployment whereby the details of the underlying modeling systems are hidden, allowing modelers to perform their science activities without the burden of considering implementation details.

  2. Variation of amino acid sequences of serum amyloid a (SAA) and immunohistochemical analysis of amyloid a (AA) in Japanese domestic cats.

    PubMed

    Tei, Meina; Uchida, Kazuyuki; Chambers, James K; Watanabe, Ken-Ichi; Tamamoto, Takashi; Ohno, Koichi; Nakayama, Hiroyuki

    2018-02-02

    Amyloid A (AA) amyloidosis, a fatal systemic amyloid disease, occurs secondary to chronic inflammatory conditions in humans. Although persistently elevated serum amyloid A (SAA) levels are required for its pathogenesis, not all individuals with chronic inflammation necessarily develop AA amyloidosis. Furthermore, many diseases in cats are associated with the elevated production of SAA, whereas only a small number actually develop AA amyloidosis. We hypothesized that a genetic mutation in the SAA gene may strongly contribute to the pathogenesis of feline AA amyloidosis. In the present study, genomic DNA from four Japanese domestic cats (JDCs) with AA amyloidosis and from five without amyloidosis was analyzed using polymerase chain reaction (PCR) amplification and direct sequencing. We identified the novel variation combination of 45R-51A in the deduced amino acid sequences of four JDCs with amyloidosis and five without. However, there was no relationship between amino acid variations and the distribution of AA amyloid deposits, indicating that differences in SAA sequences do not contribute to the pathogenesis of AA amyloidosis. Immunohistochemical analysis using antisera against the three different parts of the feline SAA protein-i.e., the N-terminal, central, and C-terminal regions-revealed that feline AA contained the C-terminus, unlike human AA. These results indicate that the cleavage and degradation of the C-terminus are not essential for amyloid fibril formation in JDCs.

  3. Architectural Implications of Cloud Computing

    DTIC Science & Technology

    2011-10-24

    Public Cloud Infrastructure-as-a- Service (IaaS) Software -as-a- Service ( SaaS ) Cloud Computing Types Platform-as-a- Service (PaaS) Based on Type of...Twitter #SEIVirtualForum © 2011 Carnegie Mellon University Software -as-a- Service ( SaaS ) Model of software deployment in which a third-party...and System Solutions (RTSS) Program. Her current interests and projects are in service -oriented architecture (SOA), cloud computing, and context

  4. Evaluation of the Trade Space Between UAS Maneuver Performance and SAA System Performance Requirements

    NASA Technical Reports Server (NTRS)

    Jack, Devin P.; Hoffler, Keith D.; Johnson, Sally C.

    2014-01-01

    A need exists to safely integrate Unmanned Aircraft Systems (UAS) into the National Airspace System. Replacing manned aircraft's see-and-avoid capability in the absence of an onboard pilot is one of the key challenges associated with safe integration. Sense-and-avoid (SAA) systems will have to achieve yet-to-be-determined required separation distances for a wide range of encounters. They will also need to account for the maneuver performance of the UAS they are paired with. The work described in this paper is aimed at developing an understanding of the trade space between UAS maneuver performance and SAA system performance requirements. An assessment of current manned and unmanned aircraft performance was used to establish potential UAS performance test matrix bounds. Then, nearterm UAS integration work was used to narrow down the scope. A simulator was developed with sufficient fidelity to assess SAA system performance requirements for a wide range of encounters. The simulator generates closest-point-of-approach (CPA) data from the wide range of UAS performance models maneuvering against a single intruder with various encounter geometries. The simulator is described herein and has both a graphical user interface and batch interface to support detailed analysis of individual UAS encounters and macro analysis of a very large set of UAS and encounter models, respectively. Results from the simulator using approximate performance data from a well-known manned aircraft is presented to provide insight into the problem and as verification and validation of the simulator. Analysis of climb, descent, and level turn maneuvers to avoid a collision is presented. Noting the diversity of backgrounds in the UAS community, a description of the UAS aerodynamic and propulsive design and performance parameters is included. Initial attempts to model the results made it clear that developing maneuver performance groups is required. Discussion of the performance groups developed and how

  5. ERA—European Radiochemists Association: Report on the activities of the Working Party for Nuclear and Radiochemistry of the Federation of European Chemical Societies

    NASA Astrophysics Data System (ADS)

    Kolar, Z. I.; Ware, A. R.

    2003-01-01

    The European Radiochemists Association started almost simultaneously with the appearance of the first issue of the Radiochemistry in Europe newsletter in August 1995. The objective of the European Radiochemists Association (ERA) is to extend and improve communication between radiochemists in Europe through a newsletter. Liaison persons within each country or group exchange details of their activities, set up a diary of relevant international events and exchange details of specialist equipment, facilities and technology. In the year 2000 the Federation of European Chemical Societies decided to form a working party on nuclear and radiochemistry. It is a formalisation of the European Radiochemists Association. Each chemical society is allowed to nominate a member to the Working Party on Nuclear and Radiochemistry. Currently we have 12 nominated members plus two invited and one observer. In addition to the ERA aims and objectives it proposes to put together a syllabus of radiochemistry for undergraduate and post-graduate students—this aspect has been a part of our support of the International Atomic Energy Agency initiative. Also the aim of the working party is to support other working parties and divisions, to press the Federation of the European Chemical Societies for financial structure. To this end an Expression of Interest has been tabled with the Framework 6 Programme for networking within radiochemistry in Europe. The WP will liaise with the International Isotope Society and the International Society on Radiopharmaceutical Chemistry and Biology to seek to communicate and to consider ways of working together.

  6. An Investigation of Alerting and Prioritization Criteria for Sense and Avoid (SAA)

    DTIC Science & Technology

    2013-10-01

    TECHNICAL REPORT RDMR-TM-13-01 AN INVESTIGATION OF ALERTING AND PRIORITIZATION CRITERIA FOR SENSE AND AVOID ( SAA ...OFFICIAL ENDORSEMENT OR APPROVAL OF THE USE OF SUCH COMMERCIAL HARDWARE OR SOFTWARE . i/ii (Blank) REPORT DOCUMENTATION PAGE Form Approved...burden to Washington Headquarters Services , Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington

  7. Biofortification of riboflavin and folate in idli batter, based on fermented cereal and pulse, by Lactococcus lactis N8 and Saccharomyces boulardii SAA655.

    PubMed

    Chandrasekar Rajendran, S C; Chamlagain, B; Kariluoto, S; Piironen, V; Saris, P E J

    2017-06-01

    Lactococcus lactis N8 and Saccharomyces boulardii SAA655 were investigated for their ability to synthesize B-vitamins (riboflavin and folate) and their functional role as microbial starters in idli fermentation. In this study, ultra-high performance liquid chromatography and microbiological assay were used to determine the total riboflavin and folate content respectively. Increased levels of folate were evident in both L. lactis N8 and S. boulardii SAA655 cultivated medium. Enhanced riboflavin levels were found only in S. boulardii SAA655 grown medium, whereas decreased riboflavin level was found in L. lactis N8 cultivated medium. To evaluate the functional role of microbial starter strains, L. lactis N8 and S. boulardii SAA655 were incorporated individually and in combination into idli batter, composed of wet grounded rice and black gram. For the experiments, naturally fermented idli batter was considered as control. The results indicated that natural idli fermentation did not enhance the riboflavin level and depleted folate levels by half. In comparison with control, L. lactis N8 and S. boulardii SAA655 incorporated idli batter (individually and in combination) increased riboflavin and folate levels by 40-90%. Apart from compensating the folate loss caused by natural fermentation, S. boulardii SAA655 fermented idli batter individually and in combination with L. lactis N8 also showed the highest leavening character. Moreover, the microbial starter incorporation did not significantly influence the pH of idli batter. Incorporation of L. lactis N8 and S. boulardii SAA655 can evidently enhance the functional and technological characteristics of idli batter. UN General Assembly declared 2016 the International Year of pulses emphasizing the importance of legumes as staple food. Furthermore, this is the first experimental report of in situ biofortifcation of riboflavin and folate using microbes in pulse based fermented staple food. The current study suggests possible

  8. IUFRO Fourth Meeting of Working Party 7.02.09, Phytophthoras in Forest and Natural Ecosystems: Meeting Summary

    Treesearch

    Susan Frankel

    2009-01-01

    On behalf of the Fourth Phytophthoras in Forest and Natural Ecosystems local organizing committee and co-chairs Everett Hansen, Clive Brasier, and Giles Hardy, I thank you for your contributions to this Working Party meeting. The past week has stimulated much thought and discussion, thanks to the 100 participants from 15 countries, 48 papers and 31 posters, two field...

  9. Quantification of VGF- and pro-SAAS-derived peptides in endocrine tissues and the brain, and their regulation by diet and cold stress.

    PubMed

    Chakraborty, Tandra R; Tkalych, Oleg; Nanno, Daniela; Garcia, Angelo L; Devi, Lakshmi A; Salton, Stephen R J

    2006-05-17

    Two novel granin-like polypeptides, VGF and pro-SAAS, which are stored in and released from secretory vesicles and are expressed widely in nervous, endocrine, and neuroendocrine tissues, play roles in the regulation of body weight, feeding, and energy expenditure. Both VGF and pro-SAAS are cleaved into peptide fragments, several of which are biologically active. We utilized a highly sensitive and specific radioimmunoassay (RIA) to immunoreactive, pro-SAAS-derived PEN peptides, developed another against immunoreactive, VGF-derived AQEE30 peptides, and quantified these peptides in various mouse tissues and brain regions. Immunoreactive AQEE30 was most abundant in the pituitary, while brain levels were highest in hypothalamus, striatum, and frontal cortex. Immunoreactive PEN levels were highest in the pancreas and spinal cord, and in brain, PEN was most abundant in striatum, hippocampus, pons and medulla, and cortex. Since both peptides were expressed in hypothalamus, a region of the brain that controls feeding and energy expenditure, double label immunofluorescence studies were employed. These demonstrated that 42% of hypothalamic arcuate neurons coexpress VGF and SAAS peptides, and that the intracellular distributions of these peptides in arcuate neurons differed. By RIA, cold stress increased immunoreactive AQEE30 and PEN peptide levels in female but not male hypothalamus, while a high fat diet increased AQEE30 and PEN peptide levels in female but not male hippocampus. VGF and SAAS-derived peptides are therefore widely expressed in endocrine, neuroendocrine, and neural tissues, can be accurately quantified by RIA, and are differentially regulated in the brain by diet and cold stress.

  10. Circuit parties.

    PubMed

    Guzman, R

    2000-03-01

    Circuit parties are extended celebrations, lasting from a day to a week, primarily attended by gay and bisexual men in their thirties and forties. These large-scale dance parties move from city to city and draw thousands of participants. The risks for contracting HIV during these parties include recreational drug use and unsafe sex. Limited data exists on the level of risk at these parties, and participants are skeptical of outside help because of past criticism of these events. Health care and HIV advocates can promote risk-reduction strategies with the cooperation of party planners and can counsel individuals to personally reduce their own risk. To convey the message, HIV prevention workers should emphasize positive and community-centered aspects of the parties, such as taking care of friends and avoiding overdose.

  11. The internal structure of eclogite-facies ophiolite complexes: Implications from the Austroalpine outliers within the Zermatt-Saas Zone, Western Alps

    NASA Astrophysics Data System (ADS)

    Weber, Sebastian; Martinez, Raul

    2016-04-01

    The Western Alpine Penninic domain is a classical accretionary prism that formed after the closure of the Penninic oceans in the Paleogene. Continental and oceanic nappes were telescoped into the Western Alpine stack associated with continent-continent collision. Within the Western Alpine geologic framework, the ophiolite nappes of the Zermatt-Saas Zone and the Tsate Unit are the remnants of the southern branch of the Piemonte-Liguria ocean basin. In addition, a series of continental basement slices reported as lower Austroalpine outliers have preserved an eclogitic high-pressure imprint, and are tectonically sandwiched between these oceanic nappes. Since the outliers occur at an unusual intra-ophiolitic setting and show a polymetamorphic character, this group of continental slices is of special importance for understanding the tectono-metamorphic evolution of Western Alps. Recently, more geochronological data from the Austroalpine outliers have become available that make it possible to establish a more complete picture of their complex geological history. The Lu-Hf garnet-whole rock ages for prograde growth of garnet fall into the time interval of 52 to 62 Ma (Weber et al., 2015, Fassmer et al. 2015), but are consistently higher than the Lu-Hf garnet-whole rock ages from several other locations throughout the Zermatt-Saas zone that range from 52 to 38 Ma (Skora et al., 2015). This discrepancy suggests that the Austroalpine outliers may have been subducted earlier than the ophiolites of the Zermatt-Saas Zone and therefore have been tectonically emplaced into their present intra-ophiolite position. This points to the possibility that the Zermatt-Saas Zone consists of tectonic subunits, which reached their respective pressure peaks over a prolonged time period, approximately 10-20 Ma. The pressure-temperature estimates from several members of the Austroalpine outliers indicate a complex distribution of metamorphic peak conditions, without ultrahigh

  12. Structure of Serum Amyloid A Suggests a Mechanism for Selective Lipoprotein Binding and Functions: SAA as a Hub in Macromolecular Interaction Networks

    PubMed Central

    Frame, Nicholas M.; Gursky, Olga

    2016-01-01

    Serum amyloid A is a major acute-phase plasma protein that modulates innate immunity and cholesterol homeostasis. We combine sequence analysis with x-ray crystal structures to postulate that SAA acts as an intrinsically disordered hub mediating interactions among proteins, lipids and proteoglycans. A structural model of lipoprotein-bound SAA monomer is proposed wherein two α-helices from the N-domain form a concave hydrophobic surface that binds lipoproteins. A C-domain, connected to the N-domain via a flexible linker, binds polar/charged ligands including cell receptors, bridging them with lipoproteins and re-routing cholesterol transport. Our model is supported by the SAA cleavage in the inter-domain linker to generate the 1–76 fragment deposited in reactive amyloidosis. This model sheds new light on functions of this enigmatic protein. PMID:26918388

  13. 31 CFR 800.220 - Party or parties to a transaction.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (Continued) OFFICE OF INVESTMENT SECURITY, DEPARTMENT OF THE TREASURY REGULATIONS PERTAINING TO MERGERS, ACQUISITIONS, AND TAKEOVERS BY FOREIGN PERSONS Definitions § 800.220 Party or parties to a transaction. The terms party to a transaction and parties to a transaction mean: (a) In the case of an acquisition of an...

  14. How Many Political Parties Should Brazil Have? A Data-Driven Method to Assess and Reduce Fragmentation in Multi-Party Political Systems

    PubMed Central

    Vaz de Melo, Pedro O. S.

    2015-01-01

    In June 2013, Brazil faced the largest and most significant mass protests in a generation. These were exacerbated by the population’s disenchantment towards its highly fragmented party system, which is composed by a very large number of political parties. Under these circumstances, presidents are constrained by informal coalition governments, bringing very harmful consequences to the country. In this work I propose ARRANGE, a d A ta d R iven method fo R A ssessing and reduci NG party fragm E ntation in a country. ARRANGE uses as input the roll call data for congress votes on bills and amendments as a proxy for political preferences and ideology. With that, ARRANGE finds the minimum number of parties required to house all congressmen without decreasing party discipline. When applied to Brazil’s historical roll call data, ARRANGE was able to generate 23 distinct configurations that, compared with the status quo, have (i) a significant smaller number of parties, (ii) a higher discipline of partisans towards their parties and (iii) a more even distribution of partisans into parties. ARRANGE is fast and parsimonious, relying on a single, intuitive parameter. PMID:26466365

  15. 42 CFR 3.506 - Rights of the parties.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Rights of the parties. 3.506 Section 3.506 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS PATIENT SAFETY ORGANIZATIONS AND PATIENT SAFETY WORK PRODUCT Enforcement Program § 3.506 Rights of the parties. (a) Except as...

  16. 42 CFR 3.506 - Rights of the parties.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Rights of the parties. 3.506 Section 3.506 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS PATIENT SAFETY ORGANIZATIONS AND PATIENT SAFETY WORK PRODUCT Enforcement Program § 3.506 Rights of the parties. (a) Except as...

  17. Maximum production of fermentable sugars from barley straw using optimized soaking in aqueous ammonia (SAA) pretreatment

    USDA-ARS?s Scientific Manuscript database

    Soaking in aqueous ammonia (SAA) pretreatment was investigated to improve enzymatic digestibility and consequently to increase total fermentable sugar production from barley straw. Various effects of pretreatment process parameters, such as reaction temperature, reaction time, solid:liquid ratio, an...

  18. Key discussions from the Working Party on Disorders of Sex Development (DSD) evaluation, Foundation Merieux, Annecy, France, March 14-17, 2012

    PubMed Central

    2013-01-01

    Four topics from the DSD Working Party, a meeting to provide information regarding future studies, reported here are the complexities of hypospadias, surgical treatment of virilized genitalia of 46,XX DSD individuals, advances in phalloplasty and psychological, social and sexual outcomes. PMID:23829860

  19. Third-party punishers are rewarded, but third-party helpers even more so.

    PubMed

    Raihani, Nichola J; Bshary, Redouan

    2015-04-01

    Punishers can benefit from a tough reputation, where future partners cooperate because they fear repercussions. Alternatively, punishers might receive help from bystanders if their act is perceived as just and other-regarding. Third-party punishment of selfish individuals arguably fits these conditions, but it is not known whether third-party punishers are rewarded for their investments. Here, we show that third-party punishers are indeed rewarded by uninvolved bystanders. Third parties were presented with the outcome of a dictator game in which the dictator was either selfish or fair and were allocated to one of three treatments in which they could choose to do nothing or (1) punish the dictator, (2) help the receiver, or (3) choose between punishment and helping, respectively. A fourth player (bystander) then sees the third-party's decision and could choose to reward the third party or not. Third parties that punished selfish dictators were more likely to be rewarded by bystanders than third parties that took no action in response to a selfish dictator. However, helpful third parties were rewarded even more than third-party punishers. These results suggest that punishment could in principle evolve via indirect reciprocity, but also provide insights into why individuals typically prefer to invest in positive actions. © 2015 The Author(s).

  20. Parties heed (with caution)

    PubMed Central

    Fisher, Justin

    2011-01-01

    Despite comprehensive reform (Political Parties, Elections and Referendums Act) and recent review (Phillips Review in 2007) of party finance in Britain, public opinion of party finance remains plagued by perceptions of corruption, undue influence from wealthy donors, carefree and wasteful spending and, more generally, from the perception that there is just ‘too much money’ in politics. In this article we argue that knowledge of and attitudes to party finance matter, not least because advocates of reform have cited public opinion as evidence for reform. However, because attitudes to party finance are part of a broader attitudinal structure, opinion-led reforms are unlikely to succeed in increasing public confidence. Using data generated from YouGov’s online panel (N=2,008), we demonstrate that the public know little of the key provisions regulating party finance and attitudes to party finance can be explained along two underlying dimensions – Anti-Party Finance and Reformers. As such, we consider whether parties and politicians should be freed from the constraints of public opinion in reforming party finance. PMID:29097904

  1. Drinking at College Parties: Examining the Influence of Student Host-Status and Party-Location

    PubMed Central

    Buettner, Cynthia K.; Khurana, Atika; Slesnick, Natasha

    2011-01-01

    The present research focuses on the party related drinking behaviors of college students and explores the differences in these behaviors based on students’ host status (i.e. party host vs. party attendee). Furthermore, we examine if the differences in party hosts and attendees’ drinking behaviors vary as a function of the party location (on-campus vs. off-campus). Multiple regression analyses were conducted using data from 3,796 undergraduates at a Midwestern University. Findings revealed a significant interaction between host status and party location, such that student party hosts reported significantly greater drink consumption and related consequences as compared to party attendees, only when the party was organized off-campus. For parties organized on-campus, student hosts reported lower drink consumption as compared to attendees. College-based preventive interventions should target students likely to host off-campus parties due to their high risk for involvement in heavy drinking. PMID:21862229

  2. Drinking at college parties: examining the influence of student host-status and party-location.

    PubMed

    Buettner, Cynthia K; Khurana, Atika; Slesnick, Natasha

    2011-12-01

    The present research focuses on the party related drinking behaviors of college students and explores the differences in these behaviors based on students' host status (i.e. party host vs. party attendee). Furthermore, we examine if the differences in party hosts and attendees' drinking behaviors vary as a function of the party location (on-campus vs. off-campus). Multiple regression analyses were conducted using data from 3796 undergraduates at a Midwestern University. Findings revealed a significant interaction between host status and party location, such that student party hosts reported significantly greater drink consumption and related consequences as compared to party attendees, only when the party was organized off-campus. For parties organized on-campus, student hosts reported lower drink consumption as compared to attendees. College-based preventive interventions should target students likely to host off-campus parties due to their high risk for involvement in heavy drinking. Copyright © 2011 Elsevier Ltd. All rights reserved.

  3. The Revolutionary Party in Gramsci's Pre-Prison Educational and Political Theory and Practice

    ERIC Educational Resources Information Center

    Holst, John D.

    2009-01-01

    While most of Gramsci's party work is well known to education scholars of Gramsci, and the educational aspects of his writings have been repeatedly analyzed, what remains a constant in education-based Gramsci studies is the nearly universal minimization of this work for what it was, namely party work. For Gramsci, it would have been unthinkable to…

  4. Parties heed (with caution): Public knowledge of and attitudes towards party finance in Britain.

    PubMed

    vanHeerde-Hudson, Jennifer; Fisher, Justin

    2013-01-01

    Despite comprehensive reform ( Political Parties, Elections and Referendums Act ) and recent review (Phillips Review in 2007) of party finance in Britain, public opinion of party finance remains plagued by perceptions of corruption, undue influence from wealthy donors, carefree and wasteful spending and, more generally, from the perception that there is just 'too much money' in politics. In this article we argue that knowledge of and attitudes to party finance matter, not least because advocates of reform have cited public opinion as evidence for reform. However, because attitudes to party finance are part of a broader attitudinal structure, opinion-led reforms are unlikely to succeed in increasing public confidence. Using data generated from YouGov's online panel (N=2,008), we demonstrate that the public know little of the key provisions regulating party finance and attitudes to party finance can be explained along two underlying dimensions - Anti-Party Finance and Reformers . As such, we consider whether parties and politicians should be freed from the constraints of public opinion in reforming party finance.

  5. Clinical Application of the UK Working Party's Criteria for the Diagnosis of Atopic Dermatitis in the Chinese Population by Age Group.

    PubMed

    Wang, Li; Li, Lin-Feng

    2016-12-05

    Atopic dermatitis (AD) is a common inflammatory skin disease with an increasingly significant prevalence. The prevalence of AD depends greatly on how its diagnosis is done. The UK Working Party's diagnostic criteria for AD are simple and easy to apply without invasive laboratory tests. This study assessed the clinical utility of these criteria in China. Data were collected from 6208 patients at 31 tertiary hospitals in 13 Chinese provinces/municipalities from March 2014 to May 2014. . The agreement between the UK diagnostic criteria and the clinical records for AD was assessed by Cohen's kappa. The overall agreement between the UK diagnostic criteria and clinical diagnosis was fair (kappa = 0.40). A slightly better agreement was found in patients aged between 4 and 9 years (kappa = 0.48), while fair agreement was found in the group <4 years and the group ≥10 years (kappa = 0.27 and 0.39, respectively). Using the UK party's criteria as the standard, the sensitivity, specificity, positive predictive value, and negative predictive value of the clinical diagnosis of AD were 62.3%, 89.2%, 38.0%, and 95.7%, respectively. Our study indicates a modest ability among Chinese dermatologists to apply the UK Working Party's diagnostic criteria for AD, especially in patients aged <4 years and ≥10 years. Since there is no gold standard for AD diagnosis, it is important to determine how AD is identified when evaluating a diagnostic tool.

  6. Prospective study of rabbit antithymocyte globulin and cyclosporine for aplastic anemia from the EBMT Severe Aplastic Anaemia Working Party.

    PubMed

    Marsh, Judith C; Bacigalupo, Andrea; Schrezenmeier, Hubert; Tichelli, Andre; Risitano, Antonio M; Passweg, Jakob R; Killick, Sally B; Warren, Alan J; Foukaneli, Theodora; Aljurf, Mahmoud; Al-Zahrani, H A; Höchsmann, Britta; Schafhausen, Philip; Roth, Alexander; Franzke, Anke; Brummendorf, Tim H; Dufour, Carlo; Oneto, Rosi; Sedgwick, Philip; Barrois, Alain; Kordasti, Shahram; Elebute, Modupe O; Mufti, Ghulam J; Socie, Gerard

    2012-06-07

    Rabbit antithymocyte globulin (rATG; thymoglobulin, Genzyme) in combination with cyclosporine, as first-line immunosuppressive therapy, was evaluated prospectively in a multicenter, European, phase 2 pilot study, in 35 patients with aplastic anemia. Results were compared with 105 age- and disease severity-matched patients from the European Blood and Marrow Transplant registry, treated with horse ATG (hATG; lymphoglobulin) and cyclosporine. The primary end point was response at 6 months. At 3 months, no patients had achieved a complete response to rATG. Partial response occurred in 11 (34%). At 6 months, complete response rate was 3% and partial response rate 37%. There were 10 deaths after rATG (28.5%) and 1 after subsequent HSCT. Infections were the main cause of death in 9 of 10 patients. The best response rate was 60% for rATG and 67% for hATG. For rATG, overall survival at 2 years was 68%, compared with 86% for hATG (P = .009). Transplant-free survival was 52% for rATG and 76% for hATG (P = .002). On multivariate analysis, rATG (hazard ratio = 3.9, P = .003) and age more than 37 years (hazard ratio = 4.7, P = .0008) were independent adverse risk factors for survival. This study was registered at www.clinicaltrials.gov as NCT00471848.

  7. Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen. Working Party of the British Committee for Standards in Haematology Clinical Haematology Task Force.

    PubMed Central

    1996-01-01

    Overwhelming postsplenectomy infection should be preventable if simple precautions are taken. An ad hoc working party of the British Committee for Standards in Haematology has reviewed recommendations for patients without a spleen and drawn up a consensus. Members of the working party were selected for their personal expertise and to represent relevant professional bodies. The guidelines, which are set out below, include and extend the chief medical officer's 1994 update. PMID:8601117

  8. Party on wheels: mobile party spaces in the Norwegian high school graduation celebration.

    PubMed

    Fjaer, Eivind Grip; Pedersen, Willy; Sandberg, Sveinung

    2016-06-01

    Research on partying and nightlife often emphasizes commercial control while overlooking participants' creativity and agency. Due to their age, appearance and transgressive partying, participants in the Norwegian high school graduation celebration have limited access to bars and pubs in the ordinary night-time economy. To create alternative party spaces under their own control they utilize the spatial opportunities offered by automobility. Groups of students get together many years in advance and buy old buses which they refurbish to become rolling nightclubs that enable them to 'transcend space' through partying while on the move. These mobile party spaces provide a material and symbolic centre of communion and a tight space for physical assembly that enhances the production of intense positive emotions. In a cat-and-mouse game with the police, the buses provide a sense of nomadic autonomy, and enable participants to drink heavily for days on end. The study examines how youth may creatively zone their own party spaces within the context of automobility and how these mobile spaces again shape the partying that goes on within them. While this party practice opens up for autonomy, creativity and social transgressions reminiscent of liminal phases or carnivals, at a deeper level participants clearly reproduce class-based differences and exaggerate conventional practices and symbols. © London School of Economics and Political Science 2016.

  9. Distributed Energy Resource Optimization Using a Software as Service (SaaS) Approach at the University of California, Davis Campus

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stadler, Michael; Marnay, Chris; Donadee, Jon

    2011-02-06

    Together with OSIsoft LLC as its private sector partner and matching sponsor, the Lawrence Berkeley National Laboratory (Berkeley Lab) won an FY09 Technology Commercialization Fund (TCF) grant from the U.S. Department of Energy. The goal of the project is to commercialize Berkeley Lab's optimizing program, the Distributed Energy Resources Customer Adoption Model (DER-CAM) using a software as a service (SaaS) model with OSIsoft as its first non-scientific user. OSIsoft could in turn provide optimization capability to its software clients. In this way, energy efficiency and/or carbon minimizing strategies could be made readily available to commercial and industrial facilities. Specialized versionsmore » of DER-CAM dedicated to solving OSIsoft's customer problems have been set up on a server at Berkeley Lab. The objective of DER-CAM is to minimize the cost of technology adoption and operation or carbon emissions, or combinations thereof. DER-CAM determines which technologies should be installed and operated based on specific site load, price information, and performance data for available equipment options. An established user of OSIsoft's PI software suite, the University of California, Davis (UCD), was selected as a demonstration site for this project. UCD's participation in the project is driven by its motivation to reduce its carbon emissions. The campus currently buys electricity economically through the Western Area Power Administration (WAPA). The campus does not therefore face compelling cost incentives to improve the efficiency of its operations, but is nonetheless motivated to lower the carbon footprint of its buildings. Berkeley Lab attempted to demonstrate a scenario wherein UCD is forced to purchase electricity on a standard time-of-use tariff from Pacific Gas and Electric (PG&E), which is a concern to Facilities staff. Additionally, DER-CAM has been set up to consider the variability of carbon emissions throughout the day and seasons. Two distinct

  10. "Partying" hard: party style, motives for and effects of MDMA use at rave parties.

    PubMed

    M ter Bogt, Tom F; Engels, Rutger C M E

    2005-01-01

    This study examines motives for and consequences of MDMA use at different types of dance parties in the Netherlands (2001 and 2002). Participants were 490 visitors of three different types of rave parties, "club/mellow," "trance/mainstream," and "hardcore" (34% female, mean age 22.3 years, 76.5% MDMA users). Partygoers are motivated primarily by the energetic and euphoric effects they expect from MDMA. Quantity of MDMA use is associated with hardcore and trance/mainstream party style, with the motives of euphoria, sexiness, self-insight, and sociability/flirtatiousness (negative), and with gender, educational level (negative), and MDMA use by friends. Women report more (acute) negative effects--depression, confusion, loss of control, suspiciousness, edginess, nausea, dizziness--than men; and in particular, women who are motivated to cope with their problems by using MDMA are at risk. Men's polydrug use and notably their motivation to conform to friends by using MDMA are associated with negative effects.

  11. W-state Analyzer and Multi-party Measurement-device-independent Quantum Key Distribution

    PubMed Central

    Zhu, Changhua; Xu, Feihu; Pei, Changxing

    2015-01-01

    W-state is an important resource for many quantum information processing tasks. In this paper, we for the first time propose a multi-party measurement-device-independent quantum key distribution (MDI-QKD) protocol based on W-state. With linear optics, we design a W-state analyzer in order to distinguish the four-qubit W-state. This analyzer constructs the measurement device for four-party MDI-QKD. Moreover, we derived a complete security proof of the four-party MDI-QKD, and performed a numerical simulation to study its performance. The results show that four-party MDI-QKD is feasible over 150 km standard telecom fiber with off-the-shelf single photon detectors. This work takes an important step towards multi-party quantum communication and a quantum network. PMID:26644289

  12. Billing third party payers for pharmaceutical care services.

    PubMed

    Poirier, S; Buffington, D E; Memoli, G A

    1999-01-01

    To describe the steps pharmacists must complete when seeking compensation from third party payers for pharmaceutical care services. Government publications; professional publications, including manuals and newsletters; authors' personal experience. Pharmacists in increasing numbers are meeting with success in getting reimbursed by third party payers for patient care activities. However, many pharmacists remain reluctant to seek compensation because they do not understand the steps involved. Preparatory steps include obtaining a provider/supplier number, procuring appropriate claim forms, developing data collection and documentation systems, establishing professional fees, creating a marketing plan, and developing an accounting system. To bill for specific patient care services, pharmacists need to collect the patient's insurance information, obtain a statement of medical necessity from the patient's physician, complete the appropriate claim form accurately, and submit the claim with supporting documentation to the insurer. Although many claims from pharmacists are rejected initially, pharmacists who work with third party payers to understand the reasons for denial of payment often receive compensation when claims are resubmitted. Pharmacists who follow these guidelines for billing third party payers for pharmaceutical care services should notice an increase in the number of paid claims.

  13. Multi-party semi-quantum key distribution-convertible multi-party semi-quantum secret sharing

    NASA Astrophysics Data System (ADS)

    Yu, Kun-Fei; Gu, Jun; Hwang, Tzonelih; Gope, Prosanta

    2017-08-01

    This paper proposes a multi-party semi-quantum secret sharing (MSQSS) protocol which allows a quantum party (manager) to share a secret among several classical parties (agents) based on GHZ-like states. By utilizing the special properties of GHZ-like states, the proposed scheme can easily detect outside eavesdropping attacks and has the highest qubit efficiency among the existing MSQSS protocols. Then, we illustrate an efficient way to convert the proposed MSQSS protocol into a multi-party semi-quantum key distribution (MSQKD) protocol. The proposed approach is even useful to convert all the existing measure-resend type of semi-quantum secret sharing protocols into semi-quantum key distribution protocols.

  14. Detection of functional polymorphisms influencing the promoter activity of the SAA2 gene and their association with milk production traits in Chinese Holstein cows.

    PubMed

    Yang, S; Li, C; Xie, Y; Cui, X; Li, X; Wei, J; Zhang, Y; Yu, Y; Wang, Y; Zhang, S; Zhang, Q; Sun, D

    2015-12-01

    Our previous RNA sequencing experiment showed that the serum amyloid A2 (SAA2) gene was one of the most promising candidates for milk protein and fat traits in dairy cattle. The SAA2 gene encodes an apolipoprotein related to high-density lipoproteins. To further validate its genetic effects, genotype-phenotype associations were performed in this study. Through resequencing of the entire coding region and the 5'-regulatory region of the SAA2 gene using pooled DNA of 12 unrelated sires, one novel 3-bp insertion-deletion and five previously reported SNPs were detected. These identified SNPs were genotyped and tested for association with five milk production-related traits in 717 Chinese Holstein cows. After Bonferroni correction for multiple t-tests, five of them were found to be statistically significant for milk yield, fat yield and protein yield (P < 0.0001~0.0053). Haplotype-based association analysis revealed a similar effect on fat yield and protein yield (P = 0.0005, P = 0.0032 respectively). Then, using luciferase report assay, the regulatory effect of the three SNPs located in the promoter region (c.-22G>A; c.17G>C; c.114G>A) was evaluated on transcriptional activity. In HEK-293 cell lines, we found that constructs GCG and AGG showed higher luciferase activity compared with GCA (P < 0.01, P < 0.01 respectively). Meanwhile, the prediction of the putative differential transcription factor binding site revealed that c.17G>C and c.114G>A caused the alteration in the transcription factor. Overall, the findings presented here provide the first evidence for associations of the SAA2 gene with milk fat and protein traits, which appears to be a key candidate for milk production traits in dairy cattle. © 2015 Stichting International Foundation for Animal Genetics.

  15. Enzymatic fractionation of SAA-pretreated barley straw for production of fuel ethanol and astaxanthin as a value-added co-product

    USDA-ARS?s Scientific Manuscript database

    Barley straw was used to demonstrate a process for production of ethanol and astaxanthin as a value-added co-product. Barley straw was pretreated by soaking in aqueous ammonia (SAA) using the previously determined optimum conditions. The pretreated barley straw was first hydrolyzed with Accellerase®...

  16. Can You Party Your Way to Better Health? A Propensity Score Analysis of Block Parties and Health

    PubMed Central

    Dean, Lorraine T.; Hillier, Amy; Chau-Glendinning, Hang; Subramanian, SV; Williams, David R.; Kawachi, Ichiro

    2015-01-01

    While other indicators of social capital have been linked to health, the role of block parties on health in Black neighborhoods and on Black residents is understudied. Block parties exhibit several features of bonding social capital and are present in nearly 90% of Philadelphia’s predominantly Black neighborhoods. This analysis investigated: (1) whether or not block parties are an indicator of bonding social capital in Black neighborhoods; (2) the degree to which block parties might be related to self-rated health in the ways that other bonding social indicators are related to health; and (3) whether or not block parties are associated with average self-rated health for Black residents particularly. Using census tract-level indicators of bonding social capital and records of block parties from 2003 to 2008 for 381 Philadelphia neighborhoods (defined by census tracts), an ecological-level propensity score was generated to assess the propensity for a block party, adjusting for population demographics, neighborhood characteristics, neighborhood resources and violent crime. Results indicate that in multivariable regression, block parties were associated with increased bonding social capital in Black neighborhoods; however, the calculation of the average effect of the treatment on the treated (ATT) within each propensity score strata showed no effect of block parties on average self-rated health for Black residents. Block parties may be an indicator of bonding social capital in Philadelphia’s predominantly Black neighborhoods, but this analysis did not show a direct association between block parties and self-rated health for Black residents. Further research should consider what other health outcomes or behaviors block parties may be related to and how interventionists can leverage block parties for health promotion. PMID:26117555

  17. Impact of genomic risk factors on survival after haematopoietic stem cell transplantation for patients with acute leukaemia.

    PubMed

    Pearce, K F; Balavarca, Y; Norden, J; Jackson, G; Holler, E; Dressel, R; Greinix, H; Toubert, A; Gluckman, E; Hromadnikova, I; Sedlacek, P; Wolff, D; Holtick, U; Bickeböller, H; Dickinson, A M

    2016-12-01

    The EBMT risk score is an established tool successfully used in the prognosis of survival post-HSCT and is applicable for a range of haematological disorders. One of its main advantages is that score generation involves summation of clinical parameters that are available pretransplant. However, the EBMT risk score is recognized as not being optimal. Previous analyses, involving patients with various diagnoses, have shown that non-HLA gene polymorphisms influence outcome after allogeneic HSCT. This study is novel as it focuses only on patients having acute leukaemia (N = 458) and attempts to demonstrate how non-HLA gene polymorphisms can be added to the EBMT risk score in a Cox regression model to improve prognostic ability for overall survival. The results of the study found that three genetic factors improved EBMT risk score. The presence of MAL (rs8177374) allele T in the patient, absence of glucocorticoid receptor haplotype (consisting of rs6198, rs33389 and rs33388) ACT in the patient and absence of heat-shock protein 70-hom (+2437) (rs2227956) allele C in the patient were associated with decreased survival time. When compared to the EBMT risk score, the scores combining EBMT risk score with the genetic factors had an improved correlation with clinical outcome and better separation of risk groups. A bootstrapping technique, involving repeated testing of a model using multiple validation sets, also revealed that the newly proposed model had improved predictive value when compared to the EBMT risk score alone. Results support the view that non-HLA polymorphisms could be useful for pretransplant clinical assessment and provide evidence that polymorphisms in the recipient genotype may influence incoming donor cells, suppressing the initiation of the graft versus leukaemia effect and reducing survival. © 2016 John Wiley & Sons Ltd.

  18. 11 CFR 9002.7 - Minor party.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 11 Federal Elections 1 2011-01-01 2011-01-01 false Minor party. 9002.7 Section 9002.7 Federal Elections FEDERAL ELECTION COMMISSION PRESIDENTIAL ELECTION CAMPAIGN FUND: GENERAL ELECTION FINANCING DEFINITIONS § 9002.7 Minor party. Minor party means a political party whose candidate for the office of...

  19. 11 CFR 9002.7 - Minor party.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Minor party. 9002.7 Section 9002.7 Federal Elections FEDERAL ELECTION COMMISSION PRESIDENTIAL ELECTION CAMPAIGN FUND: GENERAL ELECTION FINANCING DEFINITIONS § 9002.7 Minor party. Minor party means a political party whose candidate for the office of...

  20. 16 CFR 1507.11 - Party poppers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Party poppers. 1507.11 Section 1507.11 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS FIREWORKS DEVICES § 1507.11 Party poppers. Party poppers (also known by other names such as “Champagne Party...

  1. Missing the Party: Political Categorization and Reasoning in the Absence of Party Label Cues.

    PubMed

    Heit, Evan; Nicholson, Stephen P

    2016-07-01

    This research addressed theoretical approaches in political science arguing that the American electorate is either poorly informed or dependent on party label cues, by assessing performance on political judgment tasks when party label information is missing. The research materials were created from the results of a national opinion survey held during a national election. The experiments themselves were run on nationally representative samples of adults, identified from another national electoral survey. Participants saw profiles of simulated individuals, including information about demographics and issue positions, but omitting party labels. In Experiment 1, participants successfully judged the likelihood of party membership based on the profiles. In Experiment 2, participants successfully voted based on their party interests. The results were mediated by participants' political knowledge. Conclusions are drawn with respect to theories from political science and issues in cognitive science regarding categorization and reasoning. Copyright © 2016 Cognitive Science Society, Inc.

  2. Let's party tonight: drinking patterns and breath alcohol values at high school parties.

    PubMed

    Schwartz, R H; Little, D L

    1997-05-01

    This study sought to determine whether the number of alcohol-containing beverages consumed by adolescents attending a "typical" high school weekend party was planned or spontaneous. A second objective was to understand the role of the designated driver and whether he or she honored a pledge of sobriety. A printed, anonymous survey with signed informed consent was distributed to 52 high school students from three different suburban high schools during three weekend high school parties. In addition, subjects underwent breath alcohol testing using the Intoximeter breath alcohol instrument. Salivary alcohol measurements were also obtained using Alco-Screen. Levels were measured in volunteers on entry and exit from the party. Fifty-two students volunteered to participate in the survey. Eleven participants volunteered to be designated drivers, nine of whom did not drink alcohol at this party. By the end of each party, the 26 boys had consumed a mean of 10 drinks, and the 16 girls had consumed 4.1 drinks, almost exactly what they had predicted at the time of arrival. By departure time, 22 (54%) of the drinkers had a breath alcohol value of .10 g/dL or greater, while only three (7%), had alcohol values of .02 g/dL or less. Blackouts were common and had been experienced by 73% of all the students surveyed. Twenty-seven percent of those surveyed had been involved in some form of physical violence while drinking. Eleven percent of the female participants reported being sexually assaulted while they or their attacker were drunk. Most of the 42 drinkers believed that it was acceptable for designated drivers to drink at least two beers. Two intoxicated designated drivers were driven home by sober friends. High school students in this study knew before attending a party the quantity of beer they would consume. Survey participants believed that it is acceptable practice for designated drivers to drink alcohol at parties; 13% of those who intended to drive after these parties were

  3. Is Having Low Motivation the Same as Not Having High Motivation? Comparing the CSAS-R and the SAAS-R

    ERIC Educational Resources Information Center

    McCoach, Betsy; Newton, Sarah D.; Siegle, Del; Baslanti, Ugur; Picho, Katherine

    2016-01-01

    The purpose of the current study was to examine the relationships among the Challenges to Scholastic Achievement Scale-Revised (CSAS-R) and The School Attitude Assessment Survey-Revised (SAAS-R) items and factors to determine whether the negative scales on the CSAS-R seemed to be measuring the same constructs as those that are measured on the…

  4. Reflexive intergroup bias in third-party punishment.

    PubMed

    Yudkin, Daniel A; Rothmund, Tobias; Twardawski, Mathias; Thalla, Natasha; Van Bavel, Jay J

    2016-11-01

    Humans show a rare tendency to punish norm-violators who have not harmed them directly-a behavior known as third-party punishment. Research has found that third-party punishment is subject to intergroup bias, whereby people punish members of the out-group more severely than the in-group. Although the prevalence of this behavior is well-documented, the psychological processes underlying it remain largely unexplored. Some work suggests that it stems from people's inherent predisposition to form alliances with in-group members and aggress against out-group members. This implies that people will show reflexive intergroup bias in third-party punishment, favoring in-group over out-group members especially when their capacity for deliberation is impaired. Here we test this hypothesis directly, examining whether intergroup bias in third-party punishment emerges from reflexive, as opposed to deliberative, components of moral cognition. In 3 experiments, utilizing a simulated economic game, we varied participants' group relationship to a transgressor, measured or manipulated the extent to which they relied on reflexive or deliberative judgment, and observed people's punishment decisions. Across group-membership manipulations (American football teams, nationalities, and baseball teams) and 2 assessments of reflexive judgment (response time and cognitive load), reflexive judgment heightened intergroup bias, suggesting that such bias in punishment is inherent to human moral cognition. We discuss the implications of these studies for theories of punishment, cooperation, social behavior, and legal practice. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  5. Party drugs - use and harm reduction.

    PubMed

    Frei, Matthew

    2010-08-01

    Party drug use, the intermittent use of stimulants, ecstasy and so-called 'designer drugs' at dance parties or 'raves', is now part of the culture of many young Australians. This article discusses the risks associated with the use of 'party drugs' and describes an useful approach to general practitioner assessment and management of patients who may be using party drugs. Party drug use is associated with a range of harms, including risks associated with behaviour while drug affected, toxicity and overdose, mental health complications and physical morbidity. Multiple substance use, particularly combining sedatives, further amplifies risk. If GPs have some understanding of these drugs and their effects, they are well placed to provide an effective intervention in party drug users by supporting the reduction of harm.

  6. International society of blood transfusion working party on red cell immunogenetics and terminology: report of the Seoul and London meetings.

    PubMed

    Storry, J R; Castilho, L; Chen, Q; Daniels, G; Denomme, G; Flegel, W A; Gassner, C; de Haas, M; Hyland, C; Keller, M; Lomas-Francis, C; Moulds, J M; Nogues, N; Olsson, M L; Peyrard, T; van der Schoot, C E; Tani, Y; Thornton, N; Wagner, F; Wendel, S; Westhoff, C; Yahalom, V

    2016-08-01

    The Working Party has met twice since the last report: in Seoul, South Korea 2014, and in London, UK 2015, both in association with the International Society of Blood Transfusion (ISBT) Congress. As in previous meetings, matters pertaining to blood group antigen nomenclature were discussed. Eleven new blood group antigens were added to seven blood group systems. This brings the current total of blood group antigens recognized by the ISBT to 346, of which 308 are clustered within 36 blood groups systems. The remaining 38 antigens are currently unassigned to a known blood group system.

  7. "Give the ladies a chance": gender and partisanship in the Prohibition Party, 1869-1912.

    PubMed

    Andersen, Lisa

    2011-01-01

    In the nineteenth-century Prohibition Party, American women ascribed new gendered meanings to party work traditionally performed by male partisans, and also drew upon their gendered roles as women, mothers, and wives to create new partisan strategies. This article investigates the political culture that sustained a remarkable departure from traditional Democratic and Republican practices, and further explores why women's contributions to the Prohibition Party declined in the early-twentieth century. In so doing, it traces how gender and gender roles shaped the meaning of party and politics, and elucidates the interplay between institutions, constituencies, and policy during one of America's most tumultuous political eras.

  8. Activist model of political party growth

    NASA Astrophysics Data System (ADS)

    Jeffs, Rebecca A.; Hayward, John; Roach, Paul A.; Wyburn, John

    2016-01-01

    The membership of British political parties has a direct influence on their political effectiveness. This paper applies the mathematics of epidemiology to the analysis of the growth and decline of such memberships. The party members are divided into activists and inactive members, where all activists influence the quality of party recruitment, but only a subset of activists recruit and thus govern numerical growth. The activists recruit for only a limited period, which acts as a restriction on further party growth. This Limited Activist model is applied to post-war and recent memberships of the Labour, Scottish National and Conservative parties. The model reproduces data trends, and relates realistically to historical narratives. It is concluded that the political parties analysed are not in danger of extinction but experience repeated periods of growth and decline in membership, albeit at lower numbers than in the past.

  9. 49 CFR 511.32 - Written interrogatories to parties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Written interrogatories to parties. 511.32 Section... Process § 511.32 Written interrogatories to parties. (a) Availability; procedures for use. Any party may serve upon any other party written interrogatories to be answered by the party served or, if the party...

  10. 43 CFR 4.1139 - Written interrogatories to parties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Written interrogatories to parties. 4.1139... Written interrogatories to parties. (a) Any party may serve upon any other party written interrogatories to be answered in writing by the party served, or if the party served is a public or private...

  11. Application of Blind Quantum Computation to Two-Party Quantum Computation

    NASA Astrophysics Data System (ADS)

    Sun, Zhiyuan; Li, Qin; Yu, Fang; Chan, Wai Hong

    2018-06-01

    Blind quantum computation (BQC) allows a client who has only limited quantum power to achieve quantum computation with the help of a remote quantum server and still keep the client's input, output, and algorithm private. Recently, Kashefi and Wallden extended BQC to achieve two-party quantum computation which allows two parties Alice and Bob to perform a joint unitary transform upon their inputs. However, in their protocol Alice has to prepare rotated single qubits and perform Pauli operations, and Bob needs to have a powerful quantum computer. In this work, we also utilize the idea of BQC to put forward an improved two-party quantum computation protocol in which the operations of both Alice and Bob are simplified since Alice only needs to apply Pauli operations and Bob is just required to prepare and encrypt his input qubits.

  12. Application of Blind Quantum Computation to Two-Party Quantum Computation

    NASA Astrophysics Data System (ADS)

    Sun, Zhiyuan; Li, Qin; Yu, Fang; Chan, Wai Hong

    2018-03-01

    Blind quantum computation (BQC) allows a client who has only limited quantum power to achieve quantum computation with the help of a remote quantum server and still keep the client's input, output, and algorithm private. Recently, Kashefi and Wallden extended BQC to achieve two-party quantum computation which allows two parties Alice and Bob to perform a joint unitary transform upon their inputs. However, in their protocol Alice has to prepare rotated single qubits and perform Pauli operations, and Bob needs to have a powerful quantum computer. In this work, we also utilize the idea of BQC to put forward an improved two-party quantum computation protocol in which the operations of both Alice and Bob are simplified since Alice only needs to apply Pauli operations and Bob is just required to prepare and encrypt his input qubits.

  13. JPRS Report, Soviet Union, Political Affairs, Preparations for the 19th Party Conference, Part 4.

    DTIC Science & Technology

    1988-10-30

    the works of V.l. Lenin and party documents of the Leninist period. Then the requirements of glasnost and their practical realization during the... during the precongress discus- sion, the sketch from Tula Oblast entitled "Restoration," etc. Letters have been published in the newspaper from those on...level, during the regular report-election campaign in the party. Discussion of the Theses of the CPSU Central Commit- tee for the 19th All-Union Party

  14. 30 CFR 880.15 - Assistance by States or Indian tribes, local authorities, and private parties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... lands and the cooperation of the State or local authorities in the work and the requisite authority to... authorities, and private parties. 880.15 Section 880.15 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION... Assistance by States or Indian tribes, local authorities, and private parties. States Indian tribes, local...

  15. 76 FR 69595 - Application of Third Party Testing Requirements; Reducing Third Party Testing Burdens

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-08

    ... subject to a third party testing requirement. Please identify specific technologies, except for those that... evaluate testing or screening technologies for consumer products (e.g., accuracy, precision, repeatability... than testing technologies? Should screening technologies be allowed only for third party conformity...

  16. The niche party concept and its measurement.

    PubMed

    Meyer, Thomas M; Miller, Bernhard

    2015-03-01

    The concept of the niche party has become increasingly popular in analyses of party competition. Yet, existing approaches vary in their definitions and their measurement approaches. We propose using a minimal definition that allows us to compare political parties in terms of their 'nicheness'. We argue that the conceptual core of the niche party concept is based on issue emphasis and that a niche party emphasizes policy areas neglected by its rivals. Based on this definition, we propose a continuous measure that allows for more fine-grained measurement of a party's 'nicheness' than the dominant, dichotomous approaches and thereby limits the risk of measurement error. Drawing on data collected by the Comparative Manifesto Project, we show that (1) our measure has high face validity and (2) exposes differences among parties that are not captured by alternative, static or dichotomous measures.

  17. Proceedings of the fourth meeting of the International Union of Forest Research Organizations (IUFRO) Working Party S07.02.09: Phytophthoras in forests and natural ecosystems

    Treesearch

    E.M. Goheen; S.J. Frankel

    2009-01-01

    The fourth meeting of the International Union of Forest Research Organizations (IUFRO) Working Party S07.02.09, Phytophthoras in Forests and Natural Ecosystems provided a forum for current research on Phytophthora species worldwide. Seventy-eight submissions describing papers and posters on recent developments in Phytophthora diseases of trees and natural ecosystems in...

  18. Data sharing in stem cell translational science: policy statement by the International Stem Cell Forum Ethics Working Party.

    PubMed

    Bredenoord, Annelien L; Mostert, Menno; Isasi, Rosario; Knoppers, Bartha M

    2015-01-01

    Data and sample sharing constitute a scientific and ethical imperative but need to be conducted in a responsible manner in order to protect individual interests as well as maintain public trust. In 2014, the Global Alliance for Genomics and Health (GA4GH) adopted a common Framework for Responsible Sharing of Genomic and Health-Related Data. The GA4GH Framework is applicable to data sharing in the stem cell field, however, interpretation is required so as to provide guidance for this specific context. In this paper, the International Stem Cell Forum Ethics Working Party discusses those principles that are specific to translational stem cell science, including engagement, data quality and safety, privacy, security and confidentiality, risk-benefit analysis and sustainability.

  19. Report on primate supply for biomedical scientific work in the UK. EUPREN UK Working Party.

    PubMed

    Owen, S; Thomas, C; West, P; Wolfensohn, S; Wood, M

    1997-10-01

    A Working Party of the UK group of European Primate Resources Network (EUPREN) considered primate supply for scientific work in the UK. Through a questionnaire, which achieved a very good response, it obtained details of primate use, sources and breeding in the UK and it put forward options to ensure that animal welfare is the best possible whilst ensuring continued supply. The questionnaire showed that contract research laboratories and pharmaceutical companies use about 80% of the 4233 primates used annually at the moment, with the rest accounted for by academic establishments and public sector laboratories. Fifty-four per cent are cynomolgus macaques (Macaca fascicularis), of which nearly 90% are captive-bred outside the European Union (EU), the remainder being bred in the UK. Nearly 90% of cynomolgus macaques are used by only five institutions. Thirty-seven per cent of primates used are marmosets (Callithrix jacchus jacchus), all of which are bred in the UK. Most of the rest are rhesus macaques (Macaca mulatta), about half of which are captive-bred outside the EU, the other half being bred in the UK. Overall primate use has increased from about 3000 per year in 1990 and users predict that requirements for all species except baboons (Papio sp.) will be maintained or increase. Marmoset breeding in the UK is already closely matched to use, and it could be increased reasonably easily if necessary. Some of the existing breeding centres of macaques in the UK would be prepared to consider expanding to supply others, although investment and imported breeding stock would be needed and it is likely that a large investment would be needed to breed a significant fraction of the macaque use in the UK. A further problem is that the users of only about 10% of the cynomolgus macaques said that they could replace this species by rhesus macaques, which are easier to breed in the UK. The questionnaire showed that much of the use of macaques would be transferred to other countries

  20. Direct and indirect effects of third-party relationships on interpersonal trust.

    PubMed

    Ferrin, Donald L; Dirks, Kurt T; Shah, Pri P

    2006-07-01

    Past studies of the determinants of interpersonal trust have focused primarily on how trust forms in isolated dyads. Yet within organizations, trust typically develops between individuals who are embedded in a complex web of existing and potential relationships. In this article, the authors identify 3 alternative ways in which a trustor and trustee may be linked to each other via third parties: network closure (linked via social interactions with third parties), trust transferability (linked via trusted third parties), and structural equivalence (linked via the similarity of their relationships with all potential third parties within the organization). Each of these is argued to influence interpersonal trust via a distinct social mechanism. The authors hypothesized that network closure and structural equivalence would predict interpersonal trust indirectly via their impact on interpersonal organizational citizenship behaviors performed within the interpersonal relationship, whereas trust transferability would predict trust directly. Social network analyses of data gathered from a medium-sized work organization provide substantial support for the hypotheses and also suggest important directions for future research. ((c) 2006 APA, all rights reserved).

  1. Chunk Alignment for Corpus-Based Machine Translation

    ERIC Educational Resources Information Center

    Kim, Jae Dong

    2011-01-01

    Since sub-sentential alignment is critically important to the translation quality of an Example-Based Machine Translation (EBMT) system, which operates by finding and combining phrase-level matches against the training examples, we developed a new alignment algorithm for the purpose of improving the EBMT system's performance. This new…

  2. Production of fermentable sugars from corn fiber using soaking in aqueous ammonia (saa) pretreatment and fermentation to succinic acid by Escherichia coli afp184

    USDA-ARS?s Scientific Manuscript database

    Conversion of corn fiber (CF), a by-product from the corn-to-ethanol conversion process, into fermentable sugar and succinic acid was investigated using soaking in aqueous ammonia (SAA) pretreatment followed by biological conversions including enzymatic hydrolysis and fermentation using genetically ...

  3. Intensive sex partying amongst gay men in Sydney.

    PubMed

    Hurley, Michael; Prestage, Garrett

    2009-08-01

    Intensive sex partying is a framework developed to analyse specific frequent behaviours amongst a small minority of gay men in Sydney, Australia. The behaviours included a higher frequency of dance party attendance, more frequent sex, more anal sex, multiple sex partners, more unprotected anal intercourse with casual partners and more frequent drug taking. These occur at a contextual intersection between a sub-group of sexually adventurous gay men and 'party boys'. The men appear to be involved in both high-risk, adventurous sex practices and a specific form of partying distinguishable from dance partying and 'clubbing'. Sex partying occurs on multiple sites (domestic spaces; within dance parties; sex parties; sex-on-premises venues) and appears to be geared to the maximisation of sexual pleasure. Intensive sex partying describes this coincidence of factors and locates them in relation to the multiple pleasures offered by sex partying. It emphasises the importance of 'intensity' in order to understand better the relations between sex, drug use, pleasure, care and risk in some gay men's lives.

  4. Stapled haemorrhoidopexy: a consensus position paper by an international working party - indications, contra-indications and technique.

    PubMed

    Corman, M L; Gravié, J-F; Hager, T; Loudon, M A; Mascagni, D; Nyström, P-O; Seow-Choen, F; Abcarian, H; Marcello, P; Weiss, E; Longo, A

    2003-07-01

    An international working party with experience in the performance of an alternative haemorrhoid operation through the use of the circular stapler was convened for the purpose of developing a consensus as to the criteria for undertaking this procedure. The agenda consisted of first, naming the operation; second, the indications and contra-indications for its performance; and third, the preferred surgical technique. Among the recommendations for individuals who plan to embark on this surgery are that experience with anorectal surgery and an understanding of anorectal anatomy are requisites; experience with circular stapling devices is essential; and the surgeon must attend a formal course which should include lectures, videos, the application of the instrument in models, and observation of the operation as performed by a surgeon recognized by his or her peers-leading ultimately to undertaking the procedure while being observed by an experienced surgeon. Following satisfactory completion of the above, independent responsibility should be determined by an individual's department of surgery.

  5. The Flagstaff Star Party Model for Using Galileoscopes: Evaluation Report

    NASA Astrophysics Data System (ADS)

    Pompea, Stephen M.; Sparks, R. T.; Dugan, C.; Dokter, E.; Schindler, K.

    2011-05-01

    The Galileoscope is a low-cost, high optical quality telescope kit designed for education and outreach during the International Year of Astronomy 2009. The Galileoscope has been used in a variety of formal and informal education settings around the world. We have been developing a model for large star parties by collaborating with school districts and Science Foundation Arizona. We held our first large start party last fall in Flagstaff and have our next one scheduled for April of 2011 in Yuma, Arizona. The model we are using includes and extensive professional development component for teacher. Each teacher attends a day-long professional development workshop that covers the optics of a telescope, how to assemble a Gaileoscope and how to make astronomical observations. Each teacher receives an optics eduction kit including all the materials necessary to do the activities in their classrooms. The teachers receive Galileoscopes and tripods for their classrooms as well. Before the star party, NOAO staff visit the classrooms to assist students and teachers with the Galileoscope and to teach observing techniques to ensure all the Galileoscopes are working and can be used at the star party. The evening of the star party students gather at the site (usually a local park or school grounds) for an evening of observing. Each student tries to find a variety of different objects to get their passports stamped. At the end of the evening, a drawing is held for students who have observed the designated objects. We will detail the process of planning and holding the star party including professional development, logistics and follow up with the students.

  6. How to hold an ethical pox party.

    PubMed

    Jamrozik, Euzebiusz

    2018-04-01

    Pox parties are a controversial alternative to vaccination for diseases such as chickenpox. Such parties involve parents infecting non-immune children by exposing them to a contagious child. If successful, infection will usually lead to immunity, thus preventing infection later in life, which, for several vaccine-preventable diseases, is more severe than childhood infection. Some may consider pox parties more morally objectionable than opting out of vaccination through non-medical exemptions. In this paper, I argue that this is not the case. Pox parties involve immediate risk of harm for children and reduce future harms, whereas opting out of vaccination places children at long-term risk of harms that increase with time, at least for some pathogens. Regarding harm to others through onward transmission of infection, this can be easily prevented in the case of pox parties-given the relatively controlled timing of infection-by quarantining attendees after the party, whereas opting out of vaccination involves risks to others that are more difficult to control. I defend three criteria for an ethical pox party: (1) that the disease is sufficiently low risk, (2) that parents consent to their child's attendance and (3) that children exposed to infection are quarantined and isolated appropriately. I argue that, if these criteria are met, pox parties are morally preferable to non-vaccination; such parties involve less risk to non-consenting others and, for some pathogens in some cases, even involve less risk for the children who participate. Thus, policies that permit non-medical exemption to vaccination should also permit ethical pox parties. Alternatively, if pox parties are not permitted, then vaccination should be mandated for those without medical contraindication. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  7. 49 CFR 661.20 - Rights of parties.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., DEPARTMENT OF TRANSPORTATION BUY AMERICA REQUIREMENTS § 661.20 Rights of parties. (a) A party adversely..., the sole right of any third party under the Buy America provision is to petition FTA under the...

  8. 49 CFR 661.20 - Rights of parties.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF TRANSPORTATION BUY AMERICA REQUIREMENTS § 661.20 Rights of parties. (a) A party adversely..., the sole right of any third party under the Buy America provision is to petition FTA under the...

  9. 49 CFR 661.20 - Rights of parties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION BUY AMERICA REQUIREMENTS § 661.20 Rights of parties. (a) A party adversely..., the sole right of any third party under the Buy America provision is to petition FTA under the...

  10. 49 CFR 661.20 - Rights of parties.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., DEPARTMENT OF TRANSPORTATION BUY AMERICA REQUIREMENTS § 661.20 Rights of parties. (a) A party adversely..., the sole right of any third party under the Buy America provision is to petition FTA under the...

  11. 49 CFR 661.20 - Rights of parties.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF TRANSPORTATION BUY AMERICA REQUIREMENTS § 661.20 Rights of parties. (a) A party adversely..., the sole right of any third party under the Buy America provision is to petition FTA under the...

  12. Multi-party quantum summation without a trusted third party based on single particles

    NASA Astrophysics Data System (ADS)

    Zhang, Cai; Situ, Haozhen; Huang, Qiong; Yang, Pingle

    We propose multi-party quantum summation protocols based on single particles, in which participants are allowed to compute the summation of their inputs without the help of a trusted third party and preserve the privacy of their inputs. Only one participant who generates the source particles needs to perform unitary operations and only single particles are needed in the beginning of the protocols.

  13. Numeracy and the Persuasive Effect of Policy Information and Party Cues

    PubMed Central

    Mérola, Vittorio; Hitt, Matthew P.

    2016-01-01

    Numeric political appeals represent a prevalent but overlooked domain of public opinion research. When can quantitative information change political attitudes, and is this change trumped by partisan effects? We analyze how numeracy—or individual differences in citizens’ ability to process and apply numeric policy information—moderates the effectiveness of numeric political appeals on a moderately salient policy issue. Results show that those low in numeracy exhibit a strong party-cue effect, treating numeric information in a superficial and heuristic fashion. Conversely, those high in numeracy are persuaded by numeric information, even when it is sponsored by the opposing party, overcoming the party-cue effect. Our results make clear that overlooking numeric ability when analyzing quantitative political appeals can mask significant persuasion effects, and we build on recent work advancing the understanding of individual differences in public opinion. PMID:27274578

  14. Designing a new structure for storing nuclear data: Progress of the Working Party for Evaluation Cooperation subgroup #38

    DOE PAGES

    Mattoon, C. M.; Beck, B. R.

    2015-12-24

    An international effort is underway to design a new structure for storing and using nuclear reaction data, with the goal of eventually replacing the current standard, ENDF-6. This effort, organized by the Working Party for Evaluation Cooperation, was initiated in 2012 and has resulted in a list of requirements and specifications for how the proposed new structure shall perform. The new structure will take advantage of new developments in computational tools, using a nested hierarchy to store data. Here, the structure can be stored in text form (such as an XML file) for human readability and data sharing, or itmore » can be stored in binary to optimize data access. In this paper, we present the progress towards completing the requirements, specifications and implementation of the new structure.« less

  15. Designing a new structure for storing nuclear data: Progress of the Working Party for Evaluation Cooperation subgroup #38

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mattoon, C. M.; Beck, B. R.

    An international effort is underway to design a new structure for storing and using nuclear reaction data, with the goal of eventually replacing the current standard, ENDF-6. This effort, organized by the Working Party for Evaluation Cooperation, was initiated in 2012 and has resulted in a list of requirements and specifications for how the proposed new structure shall perform. The new structure will take advantage of new developments in computational tools, using a nested hierarchy to store data. Here, the structure can be stored in text form (such as an XML file) for human readability and data sharing, or itmore » can be stored in binary to optimize data access. In this paper, we present the progress towards completing the requirements, specifications and implementation of the new structure.« less

  16. Predictors of breath alcohol concentrations in college parties.

    PubMed

    Croff, Julie M; Leavens, Eleanor; Olson, Kathleen

    2017-03-30

    Alcohol use and subsequent consequences are harmful for individual college students. Other students and the university can also be negatively impacted by the consequences of alcohol use. A field-based study was used to assess the alcohol use environment at college parties. Researchers replicated a previous study by driving and walking a route to identify parties primarily on Thursday, Friday, and Saturday evenings between 9:00 PM and 1:00 AM across an academic year. Parties were randomly sampled. Hosts were asked for permission to enter the party at each sampled location. A census of partygoers was attempted at each party. Participants were asked to complete a brief survey and give a breath sample. All participants were recruited into a follow-up survey. Bivariate and multivariate analyses of individual-level and party-level factors associated with intoxication are presented. The research team identified 29 parties: 16 were approached, and 12 were surveyed. Overall, 112 participants were surveyed for a response rate of approximately 28.7% of partygoers. Controlling for demographic characteristics, consumption of shots of liquor/spirits was significantly associated with a five times greater risk for intoxication. Notably, drinking games were protective of breath alcohol concentration (BrAC) risk in this model. Individuals who reported engaging in drinking games were 74% less likely to report a BrAC above the U.S. legal limit, while controlling for underage drinking in the model. Several party characteristics were identified that increased overall BrAC at the parties, including whether the party was themed, if it was a Greek life party, and whether there were illicit drugs present. Notably, when intoxication is examined by gender and party theme, women are significantly more likely to be intoxicated at themed parties: 75% were above 0.08 at themed parties compared to 35% above 0.08 at non-themed parties. Field-based data collection methods can, and should, be

  17. 49 CFR 260.29 - Third party consultants.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... REHABILITATION AND IMPROVEMENT FINANCING PROGRAM Applications for Financial Assistance § 260.29 Third party consultants. Applicants may utilize independent third-party consultants to prepare a financial evaluation of... to process the application. We encourage the use of third party consultants. ...

  18. 49 CFR 260.29 - Third party consultants.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... REHABILITATION AND IMPROVEMENT FINANCING PROGRAM Applications for Financial Assistance § 260.29 Third party consultants. Applicants may utilize independent third-party consultants to prepare a financial evaluation of... to process the application. We encourage the use of third party consultants. ...

  19. 49 CFR 260.29 - Third party consultants.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... REHABILITATION AND IMPROVEMENT FINANCING PROGRAM Applications for Financial Assistance § 260.29 Third party consultants. Applicants may utilize independent third-party consultants to prepare a financial evaluation of... to process the application. We encourage the use of third party consultants. ...

  20. 49 CFR 260.29 - Third party consultants.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... REHABILITATION AND IMPROVEMENT FINANCING PROGRAM Applications for Financial Assistance § 260.29 Third party consultants. Applicants may utilize independent third-party consultants to prepare a financial evaluation of... to process the application. We encourage the use of third party consultants. ...

  1. 11 CFR 109.34 - When may a political party committee make coordinated party expenditures?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... COORDINATED AND INDEPENDENT EXPENDITURES (2 U.S.C. 431(17), 441a(a) AND (d), AND PUB. L. 107-155 SEC. 214(c... candidate has been nominated. All pre-nomination coordinated party expenditures shall be subject to the coordinated party expenditure limitations of this subpart, whether or not the candidate on whose behalf they...

  2. The niche party concept and its measurement

    PubMed Central

    Miller, Bernhard

    2015-01-01

    The concept of the niche party has become increasingly popular in analyses of party competition. Yet, existing approaches vary in their definitions and their measurement approaches. We propose using a minimal definition that allows us to compare political parties in terms of their ‘nicheness’. We argue that the conceptual core of the niche party concept is based on issue emphasis and that a niche party emphasizes policy areas neglected by its rivals. Based on this definition, we propose a continuous measure that allows for more fine-grained measurement of a party’s ‘nicheness’ than the dominant, dichotomous approaches and thereby limits the risk of measurement error. Drawing on data collected by the Comparative Manifesto Project, we show that (1) our measure has high face validity and (2) exposes differences among parties that are not captured by alternative, static or dichotomous measures. PMID:28066152

  3. Infants in cocktail parties

    NASA Astrophysics Data System (ADS)

    Newman, Rochelle S.

    2003-04-01

    Most work on listeners' ability to separate streams of speech has focused on adults. Yet infants also find themselves in noisy environments. In order to learn from their caregivers' speech in these settings, they must first separate it from background noise such as that from television shows and siblings. Previous work has found that 7.5-month-old infants can separate streams of speech when the target voice is more intense than the distractor voice (Newman and Jusczyk, 1996), when the target voice is known to the infant (Barker and Newman, 2000) or when infants are presented with an audiovisual (rather than auditory-only) signal (Hollich, Jusczyk, and Newman, 2001). Unfortunately, the paradigm in these studies can only be used on infants at least 7.5 months of age, limiting the ability to investigate how stream segregation develops over time. The present work uses a new paradigm to explore younger infants' ability to separate streams of speech. Infants aged 4.5 months heard a female talker repeat either their own name or another infants' name, while several other voices spoke fluently in the background. We present data on infants' ability to recognize their own name in this cocktail party situation. [Work supported by NSF and NICHD.

  4. Multi-party Measurement-Device-Independent Quantum Key Distribution Based on Cluster States

    NASA Astrophysics Data System (ADS)

    Liu, Chuanqi; Zhu, Changhua; Ma, Shuquan; Pei, Changxing

    2018-03-01

    We propose a novel multi-party measurement-device-independent quantum key distribution (MDI-QKD) protocol based on cluster states. A four-photon analyzer which can distinguish all the 16 cluster states serves as the measurement device for four-party MDI-QKD. Any two out of four participants can build secure keys after the analyzers obtains successful outputs and the two participants perform post-processing. We derive a security analysis for the protocol, and analyze the key rates under different values of polarization misalignment. The results show that four-party MDI-QKD is feasible over 280 km in the optical fiber channel when the key rate is about 10- 6 with the polarization misalignment parameter 0.015. Moreover, our work takes an important step toward a quantum communication network.

  5. Throwing a Better Party: Local Mobilizing Institutions and the Youth Vote. CIRCLE Working Paper 13.

    ERIC Educational Resources Information Center

    Shea, Daniel M.

    2004-01-01

    A shrinking number of Americans are interested in politics?a trend pronounced among younger citizens. Politicians, academics, civic leaders and others are scrambling to find solutions. This study was commissioned by the Center for Information and Research on Civic Learning and Engagement (CIRCLE) and focuses on local political parties.…

  6. 14. INSPECTION PARTY IN AUTO DRIVEN THROUGH MILE ROCK TUNNEL, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. INSPECTION PARTY IN AUTO DRIVEN THROUGH MILE ROCK TUNNEL, AUG. 26, 1915. Department of Public Works, Map and Plan Room, photo #2545. - Mile Rock Tunnel, Under Forty-eighth Avenue from Cabrillo Street to San Francisco Bay at Point Lobos, San Francisco, San Francisco County, CA

  7. CRC/EORTC/NCI Joint Formulation Working Party: experiences in the formulation of investigational cytotoxic drugs.

    PubMed Central

    Beijnen, J. H.; Flora, K. P.; Halbert, G. W.; Henrar, R. E.; Slack, J. A.

    1995-01-01

    The pharmaceutical formulation of a new anti-tumour agent has often been perceived as the bottleneck in anti-cancer drug development. In order to increase the speed of this essential development step, the Cancer Research Campaign (CRC), the European Organization for Research and Treatment of Cancer (EORTC) and the National Cancer Institute (NCI) agreed in 1987 to form the Joint Formulation Working Party (JFWP). The main goal of the JFWP is to facilitate the rapid progress of a new drug through pharmaceutical developmental to preclinical toxicology and subsequently to phase I clinical trial. Under the auspices of the JFWP around 50 new agents have been developed or are currently in development. In this report we present our formulation experiences since the establishment of the JFWP with a selected number of agents: aphidicolin glycinate, bryostatin 1, carmethizole, carzelesin, combretastatin A4, dabis maleate, disulphonated aluminium phthalocyanine, E.O.9, 4-hydroxyanisole, pancratistatin, rhizoxin, Springer pro-drug, SRI 62-834, temozolomide, trimelamol and V489. The approaches used and problems presented may be of general interest to scientists in related fields and those considering submitting agents for development. PMID:7599054

  8. Bone Marrow Cell Transfer into Fetal Circulation Can Ameliorate Genetic Skin Diseases by Providing Fibroblasts to the Skin and Inducing Immune Tolerance

    PubMed Central

    Chino, Takenao; Tamai, Katsuto; Yamazaki, Takehiko; Otsuru, Satoru; Kikuchi, Yasushi; Nimura, Keisuke; Endo, Masayuki; Nagai, Miki; Uitto, Jouni; Kitajima, Yasuo; Kaneda, Yasufumi

    2008-01-01

    Recent studies have shown that skin injury recruits bone marrow-derived fibroblasts (BMDFs) to the site of injury to accelerate tissue repair. However, whether uninjured skin can recruit BMDFs to maintain skin homeostasis remains uncertain. Here, we investigated the appearance of BMDFs in normal mouse skin after embryonic bone marrow cell transplantation (E-BMT) with green fluorescent protein-transgenic bone marrow cells (GFP-BMCs) via the vitelline vein, which traverses the uterine wall and is connected to the fetal circulation. At 12 weeks of age, mice treated with E-BMT were observed to have successful engraftment of GFP-BMCs in hematopoietic tissues accompanied by induction of immune tolerance against GFP. We then investigated BMDFs in the skin of the same mice without prior injury and found that a significant number of BMDFs, which generate matrix proteins both in vitro and in vivo, were recruited and maintained after birth. Next, we performed E-BMT in a dystrophic epidermolysis bullosa mouse model (col7a1−/−) lacking type VII collagen in the cutaneous basement membrane zone. E-BMT significantly ameliorated the severity of the dystrophic epidermolysis bullosa phenotype in neonatal mice. Type VII collagen was deposited primarily in the follicular basement membrane zone in the vicinity of the BMDFs. Thus, gene therapy using E-BMT into the fetal circulation may offer a potential treatment option to ameliorate genetic skin diseases that are characterized by fibroblast dysfunction through the introduction of immune-tolerated BMDFs. PMID:18688022

  9. 45 CFR 99.22 - Rights of parties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Rights of parties. 99.22 Section 99.22 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROCEDURE FOR HEARINGS FOR THE CHILD CARE AND DEVELOPMENT FUND Hearing Procedures § 99.22 Rights of parties. All parties may: (a...

  10. GenSAA: A tool for advancing satellite monitoring with graphical expert systems

    NASA Technical Reports Server (NTRS)

    Hughes, Peter M.; Luczak, Edward C.

    1993-01-01

    During numerous contacts with a satellite each day, spacecraft analysts must closely monitor real time data for combinations of telemetry parameter values, trends, and other indications that may signify a problem or failure. As satellites become more complex and the number of data items increases, this task is becoming increasingly difficult for humans to perform at acceptable performance levels. At the NASA Goddard Space Flight Center, fault-isolation expert systems have been developed to support data monitoring and fault detection tasks in satellite control centers. Based on the lessons learned during these initial efforts in expert system automation, a new domain-specific expert system development tool named the Generic Spacecraft Analyst Assistant (GenSAA) is being developed to facilitate the rapid development and reuse of real-time expert systems to serve as fault-isolation assistants for spacecraft analysts. Although initially domain-specific in nature, this powerful tool will support the development of highly graphical expert systems for data monitoring purposes throughout the space and commercial industry.

  11. International reference reagents: antihuman globulin. An ISBT/ICSH joint working party report. International Society of Blood Transfusion. International Committee for Standardization in Haematology.

    PubMed

    Case, J; Ford, D S; Chung, A; Collins, R; Kochman, S; Mazda, T; Overbeeke, M; Perera, R; Sakuldamrongpanich, T; Scott, M; Voak, D; Zupańska, B

    1999-01-01

    An international working party has conducted a study designed to select a suitable reference reagent for antihuman globulin, to replace those first made available in 1987. The chosen preparation contains levels of anti-IgG and anti-C3 (anti-C3c and anti-C3d) potency that are considered suitable to serve for reference when evaluating either polyspecific antihuman globulin reagents or those containing their separate monospecific components. The reference material is available in 2-ml freeze-dried aliquots from seven assigned distribution centres.

  12. 28 CFR 51.7 - Political parties.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... THE VOTING RIGHTS ACT OF 1965, AS AMENDED General Provisions § 51.7 Political parties. Certain... voting effected by a political party is subject to the preclearance requirement: (a) If the change...

  13. 28 CFR 51.7 - Political parties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... THE VOTING RIGHTS ACT OF 1965, AS AMENDED General Provisions § 51.7 Political parties. Certain... voting effected by a political party is subject to the preclearance requirement: (a) If the change...

  14. The Whig Party and the Rise of Common Schools, 1837-1854: Party and Policy Reexamined

    ERIC Educational Resources Information Center

    Groen, Mark

    2008-01-01

    The question of how Whig policies affected the early development of common schools has received little examination in either political or educational histories. There is evidence, however, that Whig party politics did influence early educational reformers. This paper considers the influence of Whig party politics on the emergence of state systems…

  15. Third Party Involvement in Barroom Conflicts

    PubMed Central

    Parks, Michael J.; Osgood, D. Wayne; Felson, Richard B.; Wells, Samantha; Graham, Kathryn

    2014-01-01

    This study examines the effect of situational variables on whether third parties intervene in conflicts in barroom settings, and whether they are aggressive or not when they intervene. Based on research on bystander intervention in emergencies, we hypothesized that third parties would be most likely to become involved in incidents with features that convey greater danger of serious harm. The situational variables indicative of danger were severity of aggression, whether the aggression was one-sided or mutual, gender, and level of intoxication of the initial participants in the conflict. Analyses consist of cross-tabulations and three-level Hierarchical Logistic Models (with bar, evening, and incidents as levels) for 860 incidents of verbal and physical aggression from 503 nights of observation in 87 large bars and clubs in Toronto, Canada. Third party involvement was more likely during incidents in which: (1) the aggression was more severe; (2) the aggression was mutual (vs. one-sided) aggression; (3) only males (vs. mixed gender) were involved; and (4) participants were more intoxicated. These incident characteristics were stronger predictors of nonaggressive third party involvement than aggressive third party involvement. The findings suggest that third parties are indeed responding to the perceived danger of serious harm. Improving our knowledge about this aspect of aggressive incidents is valuable for developing prevention and intervention approaches designed to reduce aggression in bars and other locations. PMID:23494773

  16. 29 CFR 1955.17 - Determination of parties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Determination of parties. (a) The designated State agency or agencies and the Department of Labor, OSHA, shall... administrative law judge, be granted the right to participate as parties if he determines that the final decision... party under paragraph (a) of this section shall submit a petition to the administrative law judge within...

  17. 45 CFR 79.17 - Rights of parties.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Rights of parties. 79.17 Section 79.17 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.17 Rights of parties. Except as otherwise limited by this part, all parties may— (a) Be accompanied...

  18. 45 CFR 79.17 - Rights of parties.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Rights of parties. 79.17 Section 79.17 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.17 Rights of parties. Except as otherwise limited by this part, all parties may— (a) Be accompanied...

  19. 45 CFR 79.17 - Rights of parties.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Rights of parties. 79.17 Section 79.17 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.17 Rights of parties. Except as otherwise limited by this part, all parties may— (a) Be accompanied...

  20. 45 CFR 79.17 - Rights of parties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Rights of parties. 79.17 Section 79.17 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.17 Rights of parties. Except as otherwise limited by this part, all parties may— (a) Be accompanied...

  1. 26 CFR 301.7430-5 - Prevailing party.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Prevailing party. 301.7430-5 Section 301.7430-5... Prevailing party. (a) In general. For purposes of an award of reasonable administrative costs under section... prevailing party only if— (1) The position of the Internal Revenue Service was not substantially justified...

  2. 6 CFR 13.17 - Rights of parties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Rights of parties. 13.17 Section 13.17 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.17 Rights of parties. Except as otherwise limited by this part, all parties may: (a) Be accompanied...

  3. 29 CFR 1425.4 - Duty of parties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Duty of parties. 1425.4 Section 1425.4 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE MEDIATION ASSISTANCE IN THE FEDERAL SERVICE § 1425.4 Duty of parties. It shall be the duty of the parties to participate fully and...

  4. 26 CFR 1.7476-1 - Interested parties.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 13 2014-04-01 2014-04-01 false Interested parties. 1.7476-1 Section 1.7476-1...) INCOME TAXES (CONTINUED) The Tax Court § 1.7476-1 Interested parties. (a) In general—(1) Notice... satisfactory evidence that such applicant has notified the persons who qualify as interested parties, under...

  5. 26 CFR 1.7476-1 - Interested parties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 13 2011-04-01 2011-04-01 false Interested parties. 1.7476-1 Section 1.7476-1...) INCOME TAXES (CONTINUED) The Tax Court § 1.7476-1 Interested parties. (a) In general—(1) Notice... satisfactory evidence that such applicant has notified the persons who qualify as interested parties, under...

  6. The Evolution of the Party System and the Future of Party Politics in the Republic of Korea

    DTIC Science & Technology

    2005-01-01

    independence period.108 The obvious target was Park Chung- hee, who had been in the Japanese military as an officer and whose daughter, Park Geun- hye ...After 1963, a United Socialist Party and a People’s Party existed, but never won an election and were politically neutralized by an authoritarian... won no district seat but received at least three but no more than five percent of the vote. The remaining seats are then divided among the parties

  7. Fractionation of corn fiber treated by soaking in aqueous ammonia (SAA) for isolation of hemicellulose B and production of C5 sugars by enzyme hydrolysis

    USDA-ARS?s Scientific Manuscript database

    A process was developed to fractionate and isolate the hemicellulose B component of corn fiber generated by corn wet milling. The process consisted of pretreatment by soaking in aqueous ammonia (SAA) followed by enzymatic cellulose hydrolysis, during which the hemicellulose B was solubilized by cle...

  8. Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer.

    PubMed

    Dowling, Paul; Clarke, Colin; Hennessy, Kim; Torralbo-Lopez, Beatriz; Ballot, Jo; Crown, John; Kiernan, Ingrid; O'Byrne, Kenneth J; Kennedy, M John; Lynch, Vincent; Clynes, Martin

    2012-08-15

    Early detection, clinical management and disease recurrence monitoring are critical areas in cancer treatment in which specific biomarker panels are likely to be very important in each of these key areas. We have previously demonstrated that levels of alpha-2-heremans-schmid-glycoprotein (AHSG), complement component C3 (C3), clusterin (CLI), haptoglobin (HP) and serum amyloid A (SAA) are significantly altered in serum from patients with squamous cell carcinoma of the lung. Here, we report the abundance levels for these proteins in serum samples from patients with advanced breast cancer, colorectal cancer (CRC) and lung cancer compared to healthy controls (age and gender matched) using commercially available enzyme-linked immunosorbent assay kits. Logistic regression (LR) models were fitted to the resulting data, and the classification ability of the proteins was evaluated using receiver-operating characteristic curve and leave-one-out cross-validation (LOOCV). The most accurate individual candidate biomarkers were C3 for breast cancer [area under the curve (AUC) = 0.89, LOOCV = 73%], CLI for CRC (AUC = 0.98, LOOCV = 90%), HP for small cell lung carcinoma (AUC = 0.97, LOOCV = 88%), C3 for lung adenocarcinoma (AUC = 0.94, LOOCV = 89%) and HP for squamous cell carcinoma of the lung (AUC = 0.94, LOOCV = 87%). The best dual combination of biomarkers using LR analysis were found to be AHSG + C3 (AUC = 0.91, LOOCV = 83%) for breast cancer, CLI + HP (AUC = 0.98, LOOCV = 92%) for CRC, C3 + SAA (AUC = 0.97, LOOCV = 91%) for small cell lung carcinoma and HP + SAA for both adenocarcinoma (AUC = 0.98, LOOCV = 96%) and squamous cell carcinoma of the lung (AUC = 0.98, LOOCV = 84%). The high AUC values reported here indicated that these candidate biomarkers have the potential to discriminate accurately between control and cancer groups both individually and in combination with other proteins. Copyright © 2011 UICC.

  9. 14 CFR 302.10 - Parties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Parties. 302.10 Section 302.10 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) PROCEDURAL REGULATIONS RULES OF PRACTICE IN PROCEEDINGS Rules of General Applicability § 302.10 Parties. (a) In addition to the persons set forth in § 302.2, in...

  10. Third party involvement in barroom conflicts.

    PubMed

    Parks, Michael J; Osgood, D Wayne; Felson, Richard B; Wells, Samantha; Graham, Kathryn

    2013-01-01

    This study examines the effect of situational variables on whether third parties intervene in conflicts in barroom settings, and whether they are aggressive or not when they intervene. Based on research on bystander intervention in emergencies, we hypothesized that third parties would be most likely to become involved in incidents with features that convey greater danger of serious harm. The situational variables indicative of danger were severity of aggression, whether the aggression was one-sided or mutual, gender, and level of intoxication of the initial participants in the conflict. Analyses consist of cross-tabulations and three-level Hierarchical Logistic Models (with bar, evening, and incidents as levels) for 860 incidents of verbal and physical aggression from 503 nights of observation in 87 large bars and clubs in Toronto, Canada. Third party involvement was more likely during incidents in which: (1) the aggression was more severe; (2) the aggression was mutual (vs. one-sided) aggression; (3) only males (vs. mixed gender) were involved; and (4) participants were more intoxicated. These incident characteristics were stronger predictors of non-aggressive third party involvement than aggressive third party involvement. The findings suggest that third parties are indeed responding to the perceived danger of serious harm. Improving our knowledge about this aspect of aggressive incidents is valuable for developing prevention and intervention approaches designed to reduce aggression in bars and other locations. © 2013 Wiley Periodicals, Inc.

  11. 28 CFR 68.33 - Participation of parties and representation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... representation. 68.33 Section 68.33 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) RULES OF PRACTICE... FRAUD § 68.33 Participation of parties and representation. (a) Participation of parties. Any party shall...) Representation for parties other than the Department of Justice. Persons who may appear before the Administrative...

  12. 28 CFR 68.33 - Participation of parties and representation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... representation. 68.33 Section 68.33 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) RULES OF PRACTICE... FRAUD § 68.33 Participation of parties and representation. (a) Participation of parties. Any party shall...) Representation for parties other than the Department of Justice. Persons who may appear before the Administrative...

  13. 28 CFR 68.33 - Participation of parties and representation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... representation. 68.33 Section 68.33 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) RULES OF PRACTICE... FRAUD § 68.33 Participation of parties and representation. (a) Participation of parties. Any party shall...) Representation for parties other than the Department of Justice. Persons who may appear before the Administrative...

  14. 28 CFR 68.33 - Participation of parties and representation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... representation. 68.33 Section 68.33 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) RULES OF PRACTICE... FRAUD § 68.33 Participation of parties and representation. (a) Participation of parties. Any party shall...) Representation for parties other than the Department of Justice. Persons who may appear before the Administrative...

  15. No third-party punishment in chimpanzees

    PubMed Central

    Riedl, Katrin; Jensen, Keith; Call, Josep; Tomasello, Michael

    2012-01-01

    Punishment can help maintain cooperation by deterring free-riding and cheating. Of particular importance in large-scale human societies is third-party punishment in which individuals punish a transgressor or norm violator even when they themselves are not affected. Nonhuman primates and other animals aggress against conspecifics with some regularity, but it is unclear whether this is ever aimed at punishing others for noncooperation, and whether third-party punishment occurs at all. Here we report an experimental study in which one of humans' closest living relatives, chimpanzees (Pan troglodytes), could punish an individual who stole food. Dominants retaliated when their own food was stolen, but they did not punish when the food of third-parties was stolen, even when the victim was related to them. Third-party punishment as a means of enforcing cooperation, as humans do, might therefore be a derived trait in the human lineage. PMID:22927412

  16. The use of a national transplant registry to benchmark transplant outcome for patients undergoing autologous and allogeneic stem cell transplantation in the United Kingdom and Ireland.

    PubMed

    Russell, N H; Szydlo, R; McCann, S; Potter, M N; Craddock, C; Towlson, K; Apperley, J F

    2004-02-01

    As part of its clinical governance programme the British Society for Blood and Marrow Transplantation (BSBMT) undertook an analysis of transplant outcome for adults undergoing human leucocyte antigen - identical sibling allogeneic transplantation for chronic myeloid leukaemia (CML) in first chronic phase (CP1) or autologous transplantation for Hodgkin's disease (HD). The study aimed to compare transplant-related mortality (TRM) and survival for patients reported to the BSBMT with patients transplanted in the rest of Europe, reported to the European Group for Blood and Marrow Transplantation (EBMT). The outcomes for 104 allogeneic transplants for CML in 24 UK/Irish centres were compared with 775 allografts in 145 other European centres. For HD, 241 autografts from 38 UK/Irish centres were compared with 1145 transplants in 239 other European centres. For both diseases, the cohorts were broadly matched with the exception of CML, where 85% of patients were transplanted <1 year from diagnosis in the UK/Ireland compared with 68% in the EBMT (P = 0.001). Cox regression analysis was undertaken using known delineated variables affecting transplant outcome in addition to the registry of origin. The adjusted survival curves for CML showed no significant differences between the two groups, with 3-year survival probabilities of 70.2% and 67.1% for the EBMT and BSBMT cohorts respectively. Likewise, the analysis for HD showed overlapping survival curves, with 3-year survival probabilities of 71.8% (EBMT) and 70.8% (BSBMT). TRM was not statistically different in either disease. This study demonstrates the potential for using national registries to benchmark transplant outcome against the EBMT registry.

  17. 7 CFR 29.28 - Interested party.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Interested party. 29.28 Section 29.28 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.28 Interested party. The owner or other financially interested person...

  18. Strong polygamy of quantum correlations in multi-party quantum systems

    NASA Astrophysics Data System (ADS)

    Kim, Jeong San

    2014-10-01

    We propose a new type of polygamy inequality for multi-party quantum entanglement. We first consider the possible amount of bipartite entanglement distributed between a fixed party and any subset of the rest parties in a multi-party quantum system. By using the summation of these distributed entanglements, we provide an upper bound of the distributed entanglement between a party and the rest in multi-party quantum systems. We then show that this upper bound also plays as a lower bound of the usual polygamy inequality, therefore the strong polygamy of multi-party quantum entanglement. For the case of multi-party pure states, we further show that the strong polygamy of entanglement implies the strong polygamy of quantum discord.

  19. 40 CFR 22.11 - Intervention and non-party briefs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Intervention and non-party briefs. 22... OR SUSPENSION OF PERMITS Parties and Appearances § 22.11 Intervention and non-party briefs. (a) Intervention. Any person desiring to become a party to a proceeding may move for leave to intervene. A motion...

  20. 40 CFR 22.11 - Intervention and non-party briefs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Intervention and non-party briefs. 22... OR SUSPENSION OF PERMITS Parties and Appearances § 22.11 Intervention and non-party briefs. (a) Intervention. Any person desiring to become a party to a proceeding may move for leave to intervene. A motion...

  1. 40 CFR 22.11 - Intervention and non-party briefs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Intervention and non-party briefs. 22... OR SUSPENSION OF PERMITS Parties and Appearances § 22.11 Intervention and non-party briefs. (a) Intervention. Any person desiring to become a party to a proceeding may move for leave to intervene. A motion...

  2. 40 CFR 22.11 - Intervention and non-party briefs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Intervention and non-party briefs. 22... OR SUSPENSION OF PERMITS Parties and Appearances § 22.11 Intervention and non-party briefs. (a) Intervention. Any person desiring to become a party to a proceeding may move for leave to intervene. A motion...

  3. 40 CFR 22.11 - Intervention and non-party briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Intervention and non-party briefs. 22... OR SUSPENSION OF PERMITS Parties and Appearances § 22.11 Intervention and non-party briefs. (a) Intervention. Any person desiring to become a party to a proceeding may move for leave to intervene. A motion...

  4. 5 CFR 470.203 - Eligible parties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Eligible parties. 470.203 Section 470.203 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT RESEARCH... Eligible parties. Research may be conducted by the Office of Personnel Management, or under contract or...

  5. Modeling interactions between political parties and electors

    NASA Astrophysics Data System (ADS)

    Bagarello, F.; Gargano, F.

    2017-09-01

    In this paper we extend some recent results on an operatorial approach to the description of alliances between political parties interacting among themselves and with a basin of electors. In particular, we propose and compare three different models, deducing the dynamics of their related decision functions, i.e. the attitude of each party to form or not an alliance. In the first model the interactions between each party and their electors are considered. We show that these interactions drive the decision functions toward certain asymptotic values depending on the electors only: this is the perfect party, which behaves following the electors' suggestions. The second model is an extension of the first one in which we include a rule which modifies the status of the electors, and of the decision functions as a consequence, at some specific time step. In the third model we neglect the interactions with the electors while we consider cubic and quartic interactions between the parties and we show that we get (slightly oscillating) asymptotic values for the decision functions, close to their initial values. This is the real party, which does not listen to the electors. Several explicit situations are considered in details and numerical results are also shown.

  6. 49 CFR 1016.305 - Comments by other parties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Comments by other parties. 1016.305 Section 1016.305 Transportation Other Regulations Relating to Transportation (Continued) SURFACE TRANSPORTATION... § 1016.305 Comments by other parties. Any party to a proceeding other than the applicant and agency...

  7. 49 CFR 1016.305 - Comments by other parties.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 8 2011-10-01 2011-10-01 false Comments by other parties. 1016.305 Section 1016.305 Transportation Other Regulations Relating to Transportation (Continued) SURFACE TRANSPORTATION... § 1016.305 Comments by other parties. Any party to a proceeding other than the applicant and agency...

  8. K-Anonymous Multi-party Secret Handshakes

    NASA Astrophysics Data System (ADS)

    Xu, Shouhuai; Yung, Moti

    Anonymity-protection techniques are crucial for various commercial and financial transactions, where participants are worried about their privacy. On the other hand, authentication methods are also crucial for such interactions. Secret handshake is a relatively recent mechanism that facilitates privacy-preserving mutual authentication between communicating peers. In recent years, researchers have proposed a set of secret handshake schemes based on different assumptions about the credentials used: from one-time credentials to the more general PKI-like credentials. In this paper, we concentrate on k-anonymous secret handshake schemes based on PKI-like infrastructures. More specifically, we deal with the k-anonymous m-party (m > 2) secret handshake problem, which is significantly more involved than its two-party counterpart due to the following: When an honest user hand-shakes with m - 1 parties, it must be assured that these parties are distinct; otherwise, under the mask of anonymity a dishonest participant may clone itself in a single handshake session (i.e., assuming multiple personalities).

  9. 17 CFR 10.33 - Intervention as a party.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Intervention as a party. 10.33... Parties and Limited Participation § 10.33 Intervention as a party. (a) Petition for Leave to Intervene... affected substantially. The Administrative Law Judge may direct a petitioner requesting intervention to...

  10. 17 CFR 10.33 - Intervention as a party.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Intervention as a party. 10.33... Parties and Limited Participation § 10.33 Intervention as a party. (a) Petition for Leave to Intervene... affected substantially. The Administrative Law Judge may direct a petitioner requesting intervention to...

  11. 17 CFR 10.33 - Intervention as a party.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Intervention as a party. 10.33... Parties and Limited Participation § 10.33 Intervention as a party. (a) Petition for Leave to Intervene... affected substantially. The Administrative Law Judge may direct a petitioner requesting intervention to...

  12. 17 CFR 10.33 - Intervention as a party.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Intervention as a party. 10.33... Parties and Limited Participation § 10.33 Intervention as a party. (a) Petition for Leave to Intervene... affected substantially. The Administrative Law Judge may direct a petitioner requesting intervention to...

  13. 17 CFR 10.33 - Intervention as a party.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Intervention as a party. 10.33... Parties and Limited Participation § 10.33 Intervention as a party. (a) Petition for Leave to Intervene... affected substantially. The Administrative Law Judge may direct a petitioner requesting intervention to...

  14. Use of Third-Party Credibility in Hostile Situations.

    ERIC Educational Resources Information Center

    Gorney, Carole M.

    A study analyzed the use of third-party credibility as a deliberate and systematic public relations strategy to regain credibility for an organization faced with public hostility. Four types of third-party usage are: citizen participation, outside investigation, adversarial advocacy, and employee dissemination. Third-party credibility as a public…

  15. PartyIntents: A Portal Survey to Assess Gay and Bisexual Men's Risk Behaviors at Weekend Parties

    ERIC Educational Resources Information Center

    Ramchand, Rajeev; Becker, Kirsten; Ruder, Teague; Fisher, Michael P.

    2011-01-01

    PartyIntents examines whether portal survey methods could be used to anonymously survey gay and bisexual men about HIV-risk behaviors before and after a weekend party-oriented vacation. The study recruited 97% of eligible men and of these 489 participants 47% completed the follow-up assessment. Approximately one half of the men intended to use…

  16. The Dark Side of Altruistic Third-Party Punishment

    ERIC Educational Resources Information Center

    Leibbrandt, Andreas; Lopez-Perez, Raul

    2011-01-01

    This article experimentally studies punishment from unaffected third parties in ten different games. The authors show that third-party punishment exhibits several features that are arguably undesirable. First, third parties punish strongly a decider if she chooses a socially efficient or a Pareto efficient allocation and becomes the richest party…

  17. 21 CFR 1404.950 - Excluded Parties List System

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Excluded Parties List System 1404.950 Section 1404.950 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 1404.950 Excluded Parties List System Excluded Parties List System (EPLS) means the...

  18. Political Party System Institutionalization and Democracy: The Case of Panama

    DTIC Science & Technology

    1998-03-01

    United States foreign policy have, historically, significantly affected Panamanian politics. Giovanni Sartori has emphasized that political parties...This thesis investigates that relationship, the level of 16 Giovanni Sartori , Parties and Party Systems; A Framework for Analysis (Cambridge...analyze the level of political party institutionalization in Panama. As Giovanni Sartori succinctly states in his excellent book on parties and

  19. 12 CFR 263.102 - Prevailing party.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Prevailing party. 263.102 Section 263.102 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES... Prevailing party. Only an eligible applicant that prevailed on the merits of an adversary proceeding may...

  20. Sex Parties: Female Teen Sexual Experimentation

    ERIC Educational Resources Information Center

    Toscano, Sharyl Eve

    2006-01-01

    Adolescent participants in a study aimed at exploring the nature and characteristics of girls' dating relationships revealed the phenomenon of sex parties. These teens defined a "sex party" as an opportunity to engage in sexual contact outside of typical dating relationships. Sexual activity could involve actual intercourse, but usually involved…

  1. 42 CFR 430.83 - Rights of parties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) MEDICAL ASSISTANCE PROGRAMS GRANTS TO STATES FOR MEDICAL ASSISTANCE PROGRAMS Hearings on Conformity of State Medicaid Plans and Practice to Federal Requirements § 430.83 Rights of parties. All parties may...

  2. 15 CFR 18.18 - Comments by other parties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Comments by other parties. 18.18 Section 18.18 Commerce and Foreign Trade Office of the Secretary of Commerce ATTORNEY'S FEES AND OTHER EXPENSES Procedures for Considering Applications § 18.18 Comments by other parties. Any party to a...

  3. 15 CFR 18.18 - Comments by other parties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Comments by other parties. 18.18 Section 18.18 Commerce and Foreign Trade Office of the Secretary of Commerce ATTORNEY'S FEES AND OTHER EXPENSES Procedures for Considering Applications § 18.18 Comments by other parties. Any party to a...

  4. 15 CFR 18.18 - Comments by other parties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Comments by other parties. 18.18 Section 18.18 Commerce and Foreign Trade Office of the Secretary of Commerce ATTORNEY'S FEES AND OTHER EXPENSES Procedures for Considering Applications § 18.18 Comments by other parties. Any party to a...

  5. 15 CFR 18.18 - Comments by other parties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Comments by other parties. 18.18 Section 18.18 Commerce and Foreign Trade Office of the Secretary of Commerce ATTORNEY'S FEES AND OTHER EXPENSES Procedures for Considering Applications § 18.18 Comments by other parties. Any party to a...

  6. 15 CFR 18.18 - Comments by other parties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Comments by other parties. 18.18 Section 18.18 Commerce and Foreign Trade Office of the Secretary of Commerce ATTORNEY'S FEES AND OTHER EXPENSES Procedures for Considering Applications § 18.18 Comments by other parties. Any party to a...

  7. 12 CFR 747.603 - Prevailing party.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Prevailing party. 747.603 Section 747.603 Banks... in NCUA Board Adjudications § 747.603 Prevailing party. An eligible applicant may be a “prevailing... dismissed. In appropriate situations an applicant may also have prevailed if the outcome of the proceeding...

  8. 6 CFR 13.13 - Parties to the hearing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Parties to the hearing. 13.13 Section 13.13 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.13 Parties to the hearing. (a) The parties to the hearing will be the Defendant and the Authority...

  9. 45 CFR 99.22 - Rights of parties.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CHILD CARE AND DEVELOPMENT FUND Hearing Procedures § 99.22 Rights of parties. All parties may: (a... the issues at the hearing; (f) Present witnesses who then must be available for cross-examination by...

  10. 45 CFR 99.22 - Rights of parties.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... CHILD CARE AND DEVELOPMENT FUND Hearing Procedures § 99.22 Rights of parties. All parties may: (a... the issues at the hearing; (f) Present witnesses who then must be available for cross-examination by...

  11. 45 CFR 99.22 - Rights of parties.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... CHILD CARE AND DEVELOPMENT FUND Hearing Procedures § 99.22 Rights of parties. All parties may: (a... the issues at the hearing; (f) Present witnesses who then must be available for cross-examination by...

  12. 45 CFR 99.22 - Rights of parties.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CHILD CARE AND DEVELOPMENT FUND Hearing Procedures § 99.22 Rights of parties. All parties may: (a... the issues at the hearing; (f) Present witnesses who then must be available for cross-examination by...

  13. 25 CFR 2.11 - Answer of interested party.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Answer of interested party. 2.11 Section 2.11 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR PROCEDURES AND PRACTICE APPEALS FROM ADMINISTRATIVE ACTIONS § 2.11 Answer of interested party. (a) Any interested party wishing to participate in an appeal proceeding should file a written answer...

  14. 22 CFR 1422.11 - Rights of the parties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Rights of the parties. 1422.11 Section 1422.11... PROCEEDINGS § 1422.11 Rights of the parties. (a) A party shall have the right to appear at any hearing in... COUNSEL OF THE FEDERAL LABOR RELATIONS AUTHORITY; AND THE FOREIGN SERVICE IMPASSE DISPUTES PANEL FOREIGN...

  15. 10 CFR 13.13 - Parties to the hearing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Parties to the hearing. 13.13 Section 13.13 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.13 Parties to the hearing. (a) The parties to the hearing shall be the defendant and the authority. (b) Pursuant to 31 U.S.C. 3730(c)(5), a private...

  16. Psychometric Analyses of the Birthday Party

    ERIC Educational Resources Information Center

    Lee, Young-Sun

    2016-01-01

    The present research focuses on the psychometric properties of the Birthday Party measure for ages 3-5. The Birthday Party was developed to provide a reliable, valid, and engaging measure of early mathematical content--Number and Operation, Shape, Space, and Pattern--that can be given in either a short or a long form to English and Spanish…

  17. STEM and the Evolution of the Astronomical Star Party

    NASA Astrophysics Data System (ADS)

    Day, B. H.; Munive, P.; Franco, J.; Jones, A. P.; Shaner, A. J.; Buxner, S.; Bleacher, L.

    2015-12-01

    The astronomical star party has long been a powerful and effective way to engage the public and enhance cohesiveness within the amateur astronomy community. Early star parties tended to be strictly small, local events. But with improvements in transportation, larger regional star parties became popular. These advanced the considerable capabilities for citizen science in the amateur community, shared technology and engineering innovations in the field of telescope making, and refined numerous mathematical techniques in areas such instrument design and ephemeris generation, covering the full breadth of STEM. Advancements in astrophotography showcased at these events brought the star party from STEM to STEAM. Now, the advent of social media, web streaming, and virtual presence has facilitated the phenomenon of very large, networked star parties with international scope. These mega star parties take public engagement to a new, far greater levels, giving a vastly larger and more diverse public the opportunity to directly participate in exciting first-hand STEM activities. This presentation will recount the evolution of the star party and will focus on two examples of large, multinational, networked star parties, International Observe the Moon Night and Noche de las Estrellas. We will look at lessons learned and ways to participate.

  18. Race, Ideology, and the Tea Party: A Longitudinal Study

    PubMed Central

    Knowles, Eric D.; Lowery, Brian S.; Shulman, Elizabeth P.; Schaumberg, Rebecca L.

    2013-01-01

    The Tea Party movement, which rose to prominence in the United States after the election of President Barack Obama, provides an ideal context in which to examine the roles of racial concerns and ideology in politics. A three-wave longitudinal study tracked changes in White Americans’ self-identification with the Tea Party, racial concerns (prejudice and racial identification), and ideologies (libertarianism and social conservatism) over nine months. Latent Growth Modeling (LGM) was used to evaluate potential causal relationships between Tea Party identification and these factors. Across time points, racial prejudice was indirectly associated with movement identification through Whites’ assertions of national decline. Although initial levels of White identity did not predict change in Tea Party identification, initial levels of Tea Party identification predicted increases in White identity over the study period. Across the three assessments, support for the Tea Party fell among libertarians, but rose among social conservatives. Results are discussed in terms of legitimation theories of prejudice, the “racializing” power of political judgments, and the ideological dynamics of the Tea Party. PMID:23825630

  19. Race, ideology, and the tea party: a longitudinal study.

    PubMed

    Knowles, Eric D; Lowery, Brian S; Shulman, Elizabeth P; Schaumberg, Rebecca L

    2013-01-01

    The Tea Party movement, which rose to prominence in the United States after the election of President Barack Obama, provides an ideal context in which to examine the roles of racial concerns and ideology in politics. A three-wave longitudinal study tracked changes in White Americans' self-identification with the Tea Party, racial concerns (prejudice and racial identification), and ideologies (libertarianism and social conservatism) over nine months. Latent Growth Modeling (LGM) was used to evaluate potential causal relationships between Tea Party identification and these factors. Across time points, racial prejudice was indirectly associated with movement identification through Whites' assertions of national decline. Although initial levels of White identity did not predict change in Tea Party identification, initial levels of Tea Party identification predicted increases in White identity over the study period. Across the three assessments, support for the Tea Party fell among libertarians, but rose among social conservatives. Results are discussed in terms of legitimation theories of prejudice, the "racializing" power of political judgments, and the ideological dynamics of the Tea Party.

  20. Drawing the line in clinical treatment of companion animals: recommendations from an ethics working party.

    PubMed

    Grimm, Herwig; Bergadano, Alessandra; Musk, Gabrielle C; Otto, Klaus; Taylor, Polly M; Duncan, Juliet Clare

    2018-06-09

    Modern veterinary medicine offers numerous options for treatment and clinicians must decide on the best one to use. Interventions causing short-term harm but ultimately benefitting the animal are often justified as being in the animal's best interest. Highly invasive clinical veterinary procedures with high morbidity and low success rates may not be in the animal's best interest. A working party was set up by the European College of Veterinary Anaesthesia and Analgesia to discuss the ethics of clinical veterinary practice and improve the approach to ethically challenging clinical cases. Relevant literature was reviewed. The 'best interest principle' was translated into norms immanent to the clinic by means of the 'open question argument'. Clinical interventions with potential to cause harm need ethical justification, and suggest a comparable structure of ethical reflection to that used in the context of in vivo research should be applied to the clinical setting. To structure the ethical debate, pertinent questions for ethical decision-making were identified. These were incorporated into a prototype ethical tool developed to facilitate clinical ethical decision-making. The ethical question 'Where should the line on treatment be drawn' should be replaced by 'How should the line be drawn?' © British Veterinary Association (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  1. SaaS Platform for Time Series Data Handling

    NASA Astrophysics Data System (ADS)

    Oplachko, Ekaterina; Rykunov, Stanislav; Ustinin, Mikhail

    2018-02-01

    The paper is devoted to the description of MathBrain, a cloud-based resource, which works as a "Software as a Service" model. It is designed to maximize the efficiency of the current technology and to provide a tool for time series data handling. The resource provides access to the following analysis methods: direct and inverse Fourier transforms, Principal component analysis and Independent component analysis decompositions, quantitative analysis, magnetoencephalography inverse problem solution in a single dipole model based on multichannel spectral data.

  2. 12 CFR 263.25 - Request for document discovery from parties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Request for document discovery from parties... Request for document discovery from parties. (a) General rule. Any party may serve on any other party a... a reasonable time, place, and manner for production and performing any related acts. In lieu of...

  3. Making Higher Education Work: A Comparison of Discourses in the United Kingdom's Conservative and Labour Parties' General Election Manifestos between 1979 and 2010

    ERIC Educational Resources Information Center

    Souto-Otero, Manuel

    2011-01-01

    This article elaborates a model of social democratic and conservative discourses in relation to access, financing, management, and results of higher education. The model is contrasted with the position of the Conservative Party and the Labour Party in the United Kingdom from the late 1970s to 2010 as expressed in their electoral manifestos. The…

  4. Impact of ABO incompatibility on patients' outcome after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia - a report from the Acute Leukemia Working Party of the EBMT.

    PubMed

    Canaani, Jonathan; Savani, Bipin N; Labopin, Myriam; Huang, Xiao-Jun; Ciceri, Fabio; Arcese, William; Tischer, Johanna; Koc, Yener; Bruno, Benedetto; Gülbas, Zafer; Blaise, Didier; Maertens, Johan; Ehninger, Gerhard; Mohty, Mohamad; Nagler, Arnon

    2017-06-01

    A significant proportion of hematopoietic stem cell transplants are performed with ABO-mismatched donors. The impact of ABO mismatch on outcome following transplantation remains controversial and there are no published data regarding the impact of ABO mismatch in acute myeloid leukemia patients receiving haploidentical transplants. Using the European Blood and Marrow Transplant Acute Leukemia Working Group registry we identified 837 patients who underwent haploidentical transplantation. Comparative analysis was performed between patients who received ABO-matched versus ABO-mismatched haploidentical transplants for common clinical outcome variables. Our cohort consisted of 522 ABO-matched patients and 315 ABO-mismatched patients including 150 with minor, 127 with major, and 38 with bi-directional ABO mismatching. There were no significant differences between ABO matched and mismatched patients in terms of baseline disease and clinical characteristics. Major ABO mismatching was associated with inferior day 100 engraftment rate whereas multivariate analysis showed that bi-directional mismatching was associated with increased risk of grade II-IV acute graft- versus -host disease [hazard ratio (HR) 2.387; 95% confidence interval (CI): 1.22-4.66; P =0.01). Non-relapse mortality, relapse incidence, leukemia-free survival, overall survival, and chronic graft- versus -host disease rates were comparable between ABO-matched and -mismatched patients. Focused analysis on stem cell source showed that patients with minor mismatching transplanted with bone marrow grafts experienced increased grade II-IV acute graft- versus -host disease rates (HR 2.03; 95% CI: 1.00-4.10; P =0.04). Patients with major ABO mismatching and bone marrow grafts had decreased survival (HR=1.82; CI 95%: 1.048 - 3.18; P =0.033). In conclusion, ABO incompatibility has a marginal but significant clinical effect in acute myeloid leukemia patients undergoing haploidentical transplantation. Copyright© Ferrata

  5. Impact of ABO incompatibility on patients’ outcome after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia - a report from the Acute Leukemia Working Party of the EBMT

    PubMed Central

    Canaani, Jonathan; Savani, Bipin N; Labopin, Myriam; Huang, Xiao-jun; Ciceri, Fabio; Arcese, William; Tischer, Johanna; Koc, Yener; Bruno, Benedetto; Gülbas, Zafer; Blaise, Didier; Maertens, Johan; Ehninger, Gerhard; Mohty, Mohamad; Nagler, Arnon

    2017-01-01

    A significant proportion of hematopoietic stem cell transplants are performed with ABO-mismatched donors. The impact of ABO mismatch on outcome following transplantation remains controversial and there are no published data regarding the impact of ABO mismatch in acute myeloid leukemia patients receiving haploidentical transplants. Using the European Blood and Marrow Transplant Acute Leukemia Working Group registry we identified 837 patients who underwent haploidentical transplantation. Comparative analysis was performed between patients who received ABO-matched versus ABO-mismatched haploidentical transplants for common clinical outcome variables. Our cohort consisted of 522 ABO-matched patients and 315 ABO-mismatched patients including 150 with minor, 127 with major, and 38 with bi-directional ABO mismatching. There were no significant differences between ABO matched and mismatched patients in terms of baseline disease and clinical characteristics. Major ABO mismatching was associated with inferior day 100 engraftment rate whereas multivariate analysis showed that bi-directional mismatching was associated with increased risk of grade II–IV acute graft-versus-host disease [hazard ratio (HR) 2.387; 95% confidence interval (CI): 1.22–4.66; P=0.01). Non-relapse mortality, relapse incidence, leukemia-free survival, overall survival, and chronic graft-versus-host disease rates were comparable between ABO-matched and -mismatched patients. Focused analysis on stem cell source showed that patients with minor mismatching transplanted with bone marrow grafts experienced increased grade II–IV acute graft-versus-host disease rates (HR 2.03; 95% CI: 1.00–4.10; P=0.04). Patients with major ABO mismatching and bone marrow grafts had decreased survival (HR=1.82; CI 95%: 1.048 – 3.18; P=0.033). In conclusion, ABO incompatibility has a marginal but significant clinical effect in acute myeloid leukemia patients undergoing haploidentical transplantation. PMID:28255020

  6. Modelling the dynamics of two political parties in the presence of switching.

    PubMed

    Nyabadza, F; Alassey, Tobge Yawo; Muchatibaya, Gift

    2016-01-01

    This paper generalizes the model proposed by Misra, by considering switching between political parties. In the model proposed, the movements of members from political party B to political party C and vice versa, are considered but the net movement is considered by assuming that [Formula: see text] (a constant), which implies that the movement of members is either from party B to party C or from party C to party B. In this paper we remodel these movements through switching functions to capture how individuals switch between parties. The results provide a more comprehensive synopsis of the dynamics between two political parties.

  7. Political Parties and Democracy in Haiti

    DTIC Science & Technology

    2001-06-01

    religion or economic class; an absence of initial party development during the earliest phases of state building; the behavior of government elites... behavior of Haitian elites has more than any other factor inhibited party system institutionalization. All other efforts will be fruitless if the...citizens that it is unlikely to break down. It involves 8 behavioral and institutional changes that normalize democratic politics and narrow its

  8. 7 CFR 1782.19 - Third party agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Director may authorize third party operation, maintenance, and management of an Agency financed facility. The borrower's attorney must review the contract, management agreement, written lease, or other third party agreement and issue an opinion to the Agency as to their legal sufficiency. The borrower shall...

  9. 28 CFR 115.254 - Third-party reporting.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Third-party reporting. 115.254 Section 115.254 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Community Confinement Facilities Reporting § 115.254 Third-party reporting. The...

  10. 28 CFR 115.254 - Third-party reporting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Third-party reporting. 115.254 Section 115.254 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Community Confinement Facilities Reporting § 115.254 Third-party reporting. The...

  11. 28 CFR 115.254 - Third-party reporting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Third-party reporting. 115.254 Section 115.254 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Community Confinement Facilities Reporting § 115.254 Third-party reporting. The...

  12. 28 CFR 115.354 - Third-party reporting.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Third-party reporting. 115.354 Section 115.354 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Juvenile Facilities Reporting § 115.354 Third-party reporting. The agency shall...

  13. 28 CFR 115.354 - Third-party reporting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Third-party reporting. 115.354 Section 115.354 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Juvenile Facilities Reporting § 115.354 Third-party reporting. The agency shall...

  14. 28 CFR 115.354 - Third-party reporting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Third-party reporting. 115.354 Section 115.354 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Juvenile Facilities Reporting § 115.354 Third-party reporting. The agency shall...

  15. 49 CFR 260.29 - Third party consultants.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... REHABILITATION AND IMPROVEMENT FINANCING PROGRAM Applications for Financial Assistance § 260.29 Third party consultants. Applicants may utilize independent third-party consultants to prepare a financial evaluation of... assist FRA in the evaluation of the application and would significantly reduce the time necessary for FRA...

  16. 28 CFR 115.54 - Third-party reporting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Third-party reporting. 115.54 Section 115.54 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Adult Prisons and Jails Reporting § 115.54 Third-party reporting. The agency shall...

  17. 28 CFR 115.154 - Third-party reporting.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Third-party reporting. 115.154 Section 115.154 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Reporting § 115.154 Third-party reporting. The agency shall establish a...

  18. 28 CFR 115.154 - Third-party reporting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Third-party reporting. 115.154 Section 115.154 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Reporting § 115.154 Third-party reporting. The agency shall establish a...

  19. 28 CFR 115.54 - Third-party reporting.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Third-party reporting. 115.54 Section 115.54 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Adult Prisons and Jails Reporting § 115.54 Third-party reporting. The agency shall...

  20. 28 CFR 115.154 - Third-party reporting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Third-party reporting. 115.154 Section 115.154 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Reporting § 115.154 Third-party reporting. The agency shall establish a...

  1. 28 CFR 115.54 - Third-party reporting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Third-party reporting. 115.54 Section 115.54 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Adult Prisons and Jails Reporting § 115.54 Third-party reporting. The agency shall...

  2. The PlayParty Project in Oberlin: A Family Affair

    ERIC Educational Resources Information Center

    Bennett, Peggy D.

    2006-01-01

    This article focuses on the PlayParty family event held by the Oberlin Conservatory of Music in Ohio. Through PlayParties, families immersed themselves in singing and playing what became traditional singing games. PlayParty songs that are frequently use include Skip to My Lou, Paw Paw Patch and Punchinella.

  3. Nosy Neighbors: Third-Party Actors in Central American Conflicts

    ERIC Educational Resources Information Center

    Gleditsch, Kristian Skrede; Beardsley, Kyle

    2004-01-01

    Scholars argue that third parties make rational calculations and intervene to influence interstate dispute outcomes in favor of their own objectives. Third parties affect not only conflict outcomes but also escalation and duration. Theories of third-party involvement are applied to understand the dynamics of intrastate war. An analysis of event…

  4. 29 CFR 2200.21 - Intervention; appearance by non-parties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Intervention; appearance by non-parties. 2200.21 Section... COMMISSION RULES OF PROCEDURE Parties and Representatives § 2200.21 Intervention; appearance by non-parties... will assist in the determination of the issues in question, and that the intervention will not unduly...

  5. 29 CFR 2200.21 - Intervention; appearance by non-parties.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Intervention; appearance by non-parties. 2200.21 Section... COMMISSION RULES OF PROCEDURE Parties and Representatives § 2200.21 Intervention; appearance by non-parties... will assist in the determination of the issues in question, and that the intervention will not unduly...

  6. 29 CFR 2200.21 - Intervention; appearance by non-parties.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Intervention; appearance by non-parties. 2200.21 Section... COMMISSION RULES OF PROCEDURE Parties and Representatives § 2200.21 Intervention; appearance by non-parties... will assist in the determination of the issues in question, and that the intervention will not unduly...

  7. 29 CFR 2200.21 - Intervention; appearance by non-parties.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Intervention; appearance by non-parties. 2200.21 Section... COMMISSION RULES OF PROCEDURE Parties and Representatives § 2200.21 Intervention; appearance by non-parties... will assist in the determination of the issues in question, and that the intervention will not unduly...

  8. 29 CFR 2200.21 - Intervention; appearance by non-parties.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Intervention; appearance by non-parties. 2200.21 Section... COMMISSION RULES OF PROCEDURE Parties and Representatives § 2200.21 Intervention; appearance by non-parties... will assist in the determination of the issues in question, and that the intervention will not unduly...

  9. Party Secretaries in Chinese Higher Education Institutions: What Roles Do They Play?

    ERIC Educational Resources Information Center

    Jiang, Hua; Li, Xiaobin

    2016-01-01

    The Chinese political party in power is the Communist Party. In higher education institutions the Party secretary is a ubiquitous presence. The purpose of this study was to answer the question, "What roles do Party secretaries play?" The Party committee headed by the Party secretary in an institution is supposed to lead the institution.…

  10. Homogeneity of Political Party Preferences between Spouses

    ERIC Educational Resources Information Center

    Weiner, Terry S.

    1978-01-01

    A study investigated how political socialization within marriages affects political party affiliation. Findings indicated that the high degree of homogeneity of party preferences between spouses is due both to assortive mating and to influences of each spouse upon the other. For journal availability, see SO 506 355. (Author/DB)

  11. 29 CFR 2570.133 - Parties, how designated.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Parties, how designated. 2570.133 Section 2570.133 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... ERISA Section 502(c)(7) § 2570.133 Parties, how designated. For 502(c)(7) civil penalty proceedings...

  12. 29 CFR 2570.133 - Parties, how designated.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Parties, how designated. 2570.133 Section 2570.133 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... ERISA Section 502(c)(7) § 2570.133 Parties, how designated. For 502(c)(7) civil penalty proceedings...

  13. 29 CFR 2570.133 - Parties, how designated.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Parties, how designated. 2570.133 Section 2570.133 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... ERISA Section 502(c)(7) § 2570.133 Parties, how designated. For 502(c)(7) civil penalty proceedings...

  14. Executive Function, Visual Attention and the Cocktail Party Problem in Musicians and Non-Musicians.

    PubMed

    Clayton, Kameron K; Swaminathan, Jayaganesh; Yazdanbakhsh, Arash; Zuk, Jennifer; Patel, Aniruddh D; Kidd, Gerald

    2016-01-01

    The goal of this study was to investigate how cognitive factors influence performance in a multi-talker, "cocktail-party" like environment in musicians and non-musicians. This was achieved by relating performance in a spatial hearing task to cognitive processing abilities assessed using measures of executive function (EF) and visual attention in musicians and non-musicians. For the spatial hearing task, a speech target was presented simultaneously with two intelligible speech maskers that were either colocated with the target (0° azimuth) or were symmetrically separated from the target in azimuth (at ±15°). EF assessment included measures of cognitive flexibility, inhibition control and auditory working memory. Selective attention was assessed in the visual domain using a multiple object tracking task (MOT). For the MOT task, the observers were required to track target dots (n = 1,2,3,4,5) in the presence of interfering distractor dots. Musicians performed significantly better than non-musicians in the spatial hearing task. For the EF measures, musicians showed better performance on measures of auditory working memory compared to non-musicians. Furthermore, across all individuals, a significant correlation was observed between performance on the spatial hearing task and measures of auditory working memory. This result suggests that individual differences in performance in a cocktail party-like environment may depend in part on cognitive factors such as auditory working memory. Performance in the MOT task did not differ between groups. However, across all individuals, a significant correlation was found between performance in the MOT and spatial hearing tasks. A stepwise multiple regression analysis revealed that musicianship and performance on the MOT task significantly predicted performance on the spatial hearing task. Overall, these findings confirm the relationship between musicianship and cognitive factors including domain-general selective attention and

  15. Librarians and Party Girls: Cultural Studies and the Meaning of the Librarian.

    ERIC Educational Resources Information Center

    Radford, Marie L.; Radford, Gary P.

    2003-01-01

    Responds to Wayne Wiegand's article that criticizes library and information science by suggesting a cultural studies approach to the field. Applies the work of Stuart Hall to a media stereotype of the female librarian based on the film "Party Girl" to allow new interpretations of media images of the profession. (Author/LRW)

  16. 5 CFR 1201.122 - Filing complaint; serving documents on parties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Disciplinary Actions § 1201.122 Filing complaint; serving documents on parties. (a) Place of filing. A Special... tabbed exhibits or attachments, if any, and a certificate of service listing each party or the party's...

  17. 14 CFR 77.65 - Recommendations by parties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Recommendations by parties. 77.65 Section... Recommendations by parties. Within 20 days after the mailing of the record of hearing by the official reporter, or... copies of his recommendations for a final decision to be made by the Administrator. ...

  18. Secure multi-party quantum summation based on quantum Fourier transform

    NASA Astrophysics Data System (ADS)

    Yang, Hui-Yi; Ye, Tian-Yu

    2018-06-01

    In this paper, we propose a novel secure multi-party quantum summation protocol based on quantum Fourier transform, where the traveling particles are transmitted in a tree-type mode. The party who prepares the initial quantum states is assumed to be semi-honest, which means that she may misbehave on her own but will not conspire with anyone. The proposed protocol can resist both the outside attacks and the participant attacks. Especially, one party cannot obtain other parties' private integer strings; and it is secure for the colluding attack performed by at most n - 2 parties, where n is the number of parties. In addition, the proposed protocol calculates the addition of modulo d and implements the calculation of addition in a secret-by-secret way rather than a bit-by-bit way.

  19. A novel quantum solution to secure two-party distance computation

    NASA Astrophysics Data System (ADS)

    Peng, Zhen-wan; Shi, Run-hua; Wang, Pan-hong; Zhang, Shun

    2018-06-01

    Secure Two-Party Distance Computation is an important primitive of Secure Multiparty Computational Geometry that it involves two parties, where each party has a private point, and the two parties want to jointly compute the distance between their points without revealing anything about their respective private information. Secure Two-Party Distance Computation has very important and potential applications in settings of high secure requirements, such as privacy-preserving Determination of Spatial Location-Relation, Determination of Polygons Similarity, and so on. In this paper, we present a quantum protocol for Secure Two-Party Distance Computation by using QKD-based Quantum Private Query. The security of the protocol is based on the physical principles of quantum mechanics, instead of difficulty assumptions, and therefore, it can ensure higher security than the classical related protocols.

  20. Publishing SNP genotypes of human embryonic stem cell lines: policy statement of the International Stem Cell Forum Ethics Working Party.

    PubMed

    Knoppers, Bartha M; Isasi, Rosario; Benvenisty, Nissim; Kim, Ock-Joo; Lomax, Geoffrey; Morris, Clive; Murray, Thomas H; Lee, Eng Hin; Perry, Margery; Richardson, Genevra; Sipp, Douglas; Tanner, Klaus; Wahlström, Jan; de Wert, Guido; Zeng, Fanyi

    2011-09-01

    Novel methods and associated tools permitting individual identification in publicly accessible SNP databases have become a debatable issue. There is growing concern that current technical and ethical safeguards to protect the identities of donors could be insufficient. In the context of human embryonic stem cell research, there are no studies focusing on the probability that an hESC line donor could be identified by analyzing published SNP profiles and associated genotypic and phenotypic information. We present the International Stem Cell Forum (ISCF) Ethics Working Party's Policy Statement on "Publishing SNP Genotypes of Human Embryonic Stem Cell Lines (hESC)". The Statement prospectively addresses issues surrounding the publication of genotypic data and associated annotations of hESC lines in open access databases. It proposes a balanced approach between the goals of open science and data sharing with the respect for fundamental bioethical principles (autonomy, privacy, beneficence, justice and research merit and integrity).

  1. Secure and Resilient Cloud Computing for the Department of Defense

    DTIC Science & Technology

    2015-11-16

    platform as a service (PaaS), and software as a service ( SaaS )—that target system administrators, developers, and end-users respectively (see Table 2...interfaces (API) and services Medium Amazon Elastic MapReduce, MathWorks Cloud, Red Hat OpenShift SaaS Full-fledged applications Low Google gMail

  2. 42 CFR 1005.3 - Rights of parties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Rights of parties. 1005.3 Section 1005.3 Public Health OFFICE OF INSPECTOR GENERAL-HEALTH CARE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OIG AUTHORITIES APPEALS OF EXCLUSIONS, CIVIL MONEY PENALTIES AND ASSESSMENTS § 1005.3 Rights of parties. (a) Except as...

  3. 42 CFR 1005.3 - Rights of parties.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Rights of parties. 1005.3 Section 1005.3 Public Health OFFICE OF INSPECTOR GENERAL-HEALTH CARE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OIG AUTHORITIES APPEALS OF EXCLUSIONS, CIVIL MONEY PENALTIES AND ASSESSMENTS § 1005.3 Rights of parties. (a) Except as...

  4. 42 CFR 1005.3 - Rights of parties.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Rights of parties. 1005.3 Section 1005.3 Public Health OFFICE OF INSPECTOR GENERAL-HEALTH CARE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OIG AUTHORITIES APPEALS OF EXCLUSIONS, CIVIL MONEY PENALTIES AND ASSESSMENTS § 1005.3 Rights of parties. (a) Except as...

  5. 42 CFR 1005.3 - Rights of parties.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Rights of parties. 1005.3 Section 1005.3 Public Health OFFICE OF INSPECTOR GENERAL-HEALTH CARE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OIG AUTHORITIES APPEALS OF EXCLUSIONS, CIVIL MONEY PENALTIES AND ASSESSMENTS § 1005.3 Rights of parties. (a) Except as...

  6. 6 CFR 27.410 - Third party actions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Third party actions. 27.410 Section 27.410 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Other § 27.410 Third party actions. (a) Nothing in this part shall confer upon any person except...

  7. 6 CFR 27.410 - Third party actions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Third party actions. 27.410 Section 27.410 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Other § 27.410 Third party actions. (a) Nothing in this part shall confer upon any person except...

  8. 6 CFR 27.410 - Third party actions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 6 Domestic Security 1 2013-01-01 2013-01-01 false Third party actions. 27.410 Section 27.410 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Other § 27.410 Third party actions. (a) Nothing in this part shall confer upon any person except...

  9. 6 CFR 27.410 - Third party actions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Third party actions. 27.410 Section 27.410 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Other § 27.410 Third party actions. (a) Nothing in this part shall confer upon any person except...

  10. 6 CFR 27.410 - Third party actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Third party actions. 27.410 Section 27.410 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Other § 27.410 Third party actions. (a) Nothing in this Part shall confer upon any person except...

  11. 49 CFR 383.75 - Third party testing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) Third party tests. A State may authorize a third party tester to administer the skills tests as specified in subparts G and H of this part, if the following conditions are met: (1) The skills tests given... version of the skills tests, the same written instructions for test applicants, and the same scoring...

  12. Predicting survival using clinical risk scores and non-HLA immunogenetics.

    PubMed

    Balavarca, Y; Pearce, K; Norden, J; Collin, M; Jackson, G; Holler, E; Dressel, R; Kolb, H-J; Greinix, H; Socie, G; Toubert, A; Rocha, V; Gluckman, E; Hromadnikova, I; Sedlacek, P; Wolff, D; Holtick, U; Dickinson, A; Bickeböller, H

    2015-11-01

    Previous studies of non-histocompatibility leukocyte antigen (HLA) gene single-nucleotide polymorphisms (SNPs) on subgroups of patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) revealed an association with transplant outcome. This study further evaluated the association of non-HLA polymorphisms with overall survival in a cohort of 762 HSCT patients using data on 26 polymorphisms in 16 non-HLA genes. When viewed in addition to an already established clinical risk score (EBMT-score), three polymorphisms: rs8177374 in the gene for MyD88-adapter-like (MAL; P=0.026), rs9340799 in the oestrogen receptor gene (ESR; P=0.003) and rs1800795 in interleukin-6 (IL-6; P=0.007) were found to be associated with reduced overall survival, whereas the haplo-genotype (ACC/ACC) in IL-10 was protective (P=0.02). The addition of these non-HLA polymorphisms in a Cox regression model alongside the EBMT-score improved discrimination between risk groups and increased the level of prediction compared with the EBMT-score alone (gain in prediction capability for EBMT-genetic-score 10.8%). Results also demonstrated how changes in clinical practice through time have altered the effects of non-HLA analysis. The study illustrates the significance of non-HLA genotyping prior to HSCT and the importance of further investigation into non-HLA gene polymorphisms in risk prediction.

  13. The Radish Party

    ERIC Educational Resources Information Center

    Piotrowski, Jeff; Mildenstein, Tammy; Dungan, Kathy; Brewer, Carol

    2007-01-01

    The Radish Party inquiry is designed to teach the importance and relevance of soil organic matter to young students. In this investigation, students grow radishes in three different kinds of soils: sand, sand plus nutrients, and potting soil (soil that includes organic matter). The experience described here was conducted with first- and…

  14. Psychosocial determinants of diurnal alpha-amylase among healthy Quebec workers.

    PubMed

    Marchand, Alain; Juster, Robert-Paul; Lupien, Sonia J; Durand, Pierre

    2016-04-01

    Salivary alpha-amylase (sAA) is a stress-sensitive biomarker the shows promise as an indirect proxy of sympathetic-adrenal-medullary axis activities that are otherwise difficult to discern non-invasively. This comprehensive study investigated diurnal sAA in association with numerous psychosocial characteristics related to mental health, work stress, and non-work stress. Participants included 395 workers (56.1% women, age: M=41.3, SD=10.81) from across 34 distinct workplaces. Diurnal sAA was sampled over two non-consecutive work days at awakening, 30 min after awakening, 14h00, 16h00, and bedtime. Well-validated psychometrics and survey items were used to measure mental health (psychological distress, depression, burnout, work characteristics) (task design, demands, social relations, gratifications), and non-work characteristics (marital/parental status, economic statuses, marital and parental stress, work-family conflicts). Preliminary results revealed that men showed occasionally higher sAA concentrations than women. Multilevel regressions were used to analyze sAA concentrations nested according to levels (i) for each time-point, (ii) between workers, and (iii) across workplaces while covarying for time of awakening, sex, age, cigarette smoking, alcohol consumption, regular physical activity, psychotropic drug use, and body mass index. Main results revealed that psychological demands, support from colleagues, interpersonal conflicts, job recognition and job insecurity appear to be associated with diurnal sAA, while non-work factors did not. Our findings showing a distinct diurnal profile for sAA replicate and expand those of Nater et al. (2007, Psychoneuroendocrinology 32, 392-401), providing further evidence that sAA is associated to subjective psychosocial factors. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. 14 CFR 77.65 - Recommendations by parties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Recommendations by parties. 77.65 Section... Subpart D § 77.65 Recommendations by parties. Within 20 days after the mailing of the record of hearing by... presiding officer five copies of his recommendations for a final decision to be made by the Administrator. ...

  16. Multipartite entanglement verification resistant against dishonest parties.

    PubMed

    Pappa, Anna; Chailloux, André; Wehner, Stephanie; Diamanti, Eleni; Kerenidis, Iordanis

    2012-06-29

    Future quantum information networks will consist of quantum and classical agents, who have the ability to communicate in a variety of ways with trusted and untrusted parties and securely delegate computational tasks to untrusted large-scale quantum computing servers. Multipartite quantum entanglement is a fundamental resource for such a network and, hence, it is imperative to study the possibility of verifying a multipartite entanglement source in a way that is efficient and provides strong guarantees even in the presence of multiple dishonest parties. In this Letter, we show how an agent of a quantum network can perform a distributed verification of a source creating multipartite Greenberger-Horne-Zeilinger (GHZ) states with minimal resources, which is, nevertheless, resistant against any number of dishonest parties. Moreover, we provide a tight tradeoff between the level of security and the distance between the state produced by the source and the ideal GHZ state. Last, by adding the resource of a trusted common random source, we can further provide security guarantees for all honest parties in the quantum network simultaneously.

  17. 27 CFR 70.26 - Third-party recordkeepers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) Definitions—(1) Accountant. A person is an “accountant” under 26 U.S.C. 7609(a)(3)(F) for purposes of... certified under State law as an accountant. (2) Attorney. A person is an “attorney” under 26 U.S.C. 7609(a...-party recordkeeper. Thus, for instance, an accountant is not a third-party recordkeeper (by reason of...

  18. Outcomes of unrelated cord blood transplantation in patients with multiple myeloma: a survey on behalf of Eurocord, the Cord Blood Committee of Cellular Therapy and Immunobiology Working Party, and the Chronic Leukemia Working Party of the EBMT.

    PubMed

    Paviglianiti, Annalisa; Xavier, Erick; Ruggeri, Annalisa; Ceballos, Patrice; Deconinck, Eric; Cornelissen, Jan J; Nguyen-Quoc, Stephanie; Maillard, Natacha; Sanz, Guillermo; Rohrlich, Pierre-Simon; Garderet, Laurent; Volt, Fernanda; Rocha, Vanderson; Kroeger, Nicolaus; Gluckman, Eliane; Fegueux, Nathalie; Mohty, Mohamad

    2016-09-01

    Although allogeneic stem cell transplantation is not a standard therapy for multiple myeloma, some patients can benefit from this intense therapy. There are few reports on outcomes after umbilical cord blood transplantation in multiple myeloma, and investigation of this procedure is warranted. We retrospectively analyzed 95 patients, 85 with multiple myeloma and 10 with plasma cell leukemia, receiving single or double umbilical cord blood transplantation from 2001 to 2013. Median follow up was 41 months. The majority of patients received a reduced intensity conditioning. The cumulative incidence of neutrophil engraftment was 97%±3% at 60 days, and that of 100-day acute graft-versus-host disease grade II-IV was 41%±5%. Chronic graft-versus-host disease at two years was 22%±4%. Relapse and non-relapse mortality was 47%±5% and 29%±5% at three years, respectively. Three-year progression-free survival and overall survival were 24%±5% and 40%±5%, respectively. Anti-thymocyte globulin was associated with decreased incidence of acute graft-versus-host disease, higher non-relapse mortality, decreased overall and progression-free survival. Patients with high cytogenetic risk had higher relapse, and worse overall and progression-free survival. In conclusion, umbilical cord blood transplantation is feasible for multiple myeloma patients. Copyright© Ferrata Storti Foundation.

  19. Physiological responses and partisan bias: beyond self-reported measures of party identification.

    PubMed

    Petersen, Michael Bang; Giessing, Ann; Nielsen, Jesper

    2015-01-01

    People are biased partisans: they tend to agree with policies from political parties they identify with, independent of policy content. Here, we investigate how physiological reactions to political parties shape bias. Using changes in galvanic skin conductance responses to the visual presentation of party logos, we obtained an implicit and physiological measure of the affective arousal associated with political parties. Subsequently, we exposed subjects to classical party cue experiments where the party sponsors of specific policies were experimentally varied. We found that partisan bias only obtains among those exhibiting a strong physiological reaction to the party source; being a self-reported party identifier is not sufficient on its own. This suggests that partisan bias is rooted in implicit, affective reactions.

  20. Physiological Responses and Partisan Bias: Beyond Self-Reported Measures of Party Identification

    PubMed Central

    Petersen, Michael Bang; Giessing, Ann; Nielsen, Jesper

    2015-01-01

    People are biased partisans: they tend to agree with policies from political parties they identify with, independent of policy content. Here, we investigate how physiological reactions to political parties shape bias. Using changes in galvanic skin conductance responses to the visual presentation of party logos, we obtained an implicit and physiological measure of the affective arousal associated with political parties. Subsequently, we exposed subjects to classical party cue experiments where the party sponsors of specific policies were experimentally varied. We found that partisan bias only obtains among those exhibiting a strong physiological reaction to the party source; being a self-reported party identifier is not sufficient on its own. This suggests that partisan bias is rooted in implicit, affective reactions. PMID:26010527

  1. Cleaning and disinfection of equipment for gastrointestinal endoscopy. Report of a Working Party of the British Society of Gastroenterology Endoscopy Committee.

    PubMed

    1998-04-01

    Two per cent glutaraldehyde is the most commonly used disinfectant in endoscopy units within the UK. Unfortunately adverse reactions to glutaraldehyde are common among endoscopy personnel and the Health and Safety Commission has recommended substantial reductions in atmospheric levels of glutaraldehyde in order to comply with the Control of Substances Hazardous to Health Regulations, 1994. The Working Party addressed ways of eliminating or minimising exposure to glutaraldehyde in endoscopy units by reviewing alternative disinfectants and the use of automated washer/disinfectors. Alternatives to glutaraldehyde must be at least as microbicidal as glutaraldehyde, non-irritating and compatible with endoscope components and decontamination equipment. Peracetic acid is a highly effective disinfectant and may be a suitable alternative to glutaraldehyde. Peracetic acid has a vinegary-like odour and is claimed to be less irritating than glutaraldehyde. Experience with this agent remains relatively limited and the Working Party recommends that peracetic acid should be used in sealed or exhaust ventilated facilities until further experience is obtained. It is considerably more expensive than glutaraldehyde, is less stable and large volumes have to be stored. It causes cosmetic (but not functional) damage to endoscopes and is not compatible with some washer/ disinfectors. Chlorine dioxide is a powerful oxidising agent and highly effective as a disinfectant. Once activated it must be stored in sealed containers with little head space. Fumes cause irritation and sealed or exhaust ventilated facilities are necessary. The agent may damage some metallic and polymer components of endoscopes and automated washer/disinfectors and compatibility should be established with equipment manufacturers before the agent is used. Other disinfectants such as peroxygen compounds and quaternary ammonium derivatives are less suitable because of unsatisfactory mycobactericidal and/or virucidal

  2. Creating A Nationwide Nonpartisan Initiative for Family Caregivers in Political Party Platforms.

    PubMed

    Scribner, Ben; Lynn, Joanne; Walker, Victoria; Morgan, Les; Montgomery, Anne; Blair, Elizabeth; Baird, Davis; Goldschmidt, Barbara; Kirschenbaum, Naomi

    2017-06-01

    Policymakers have been slow to support family caregivers, and political agendas mostly fail to address the cost burdens, impact on employment and productivity, and other challenges in taking on long-term care tasks. This project set out to raise policymakers' awareness of family caregivers through proposals to Republican and Democratic party platforms during the 2016 political season. The Family Caregiver Platform Project (FCPP) reviewed the state party platform submission process for Democratic and Republican parties in all 50 states and the District of Columbia. We built a website to make each process understandable by caregiver advocates. We designed model submissions to help volunteers tailor a proposal and recruited caregiver advocates participating in their state process. Finally, we mobilized a ground operation in many states and followed the progress of submissions in each state, as well as the formation of the national platforms. In 39 states, at least one party, Republican or Democrat, hosted a state party platform process. As of September 2016 FCPP volunteers submitted proposals to 29 state parties in 22 states. Family caregiver language was added to eight state party platforms, one state party resolution, two bipartisan legislative resolutions, and one national party platform. The FCPP generated a non-partisan grassroots effort to educate and motivate policymakers to address caregiving issues and solutions. Democratic party leaders provided more opportunities to connect with political leaders, with seven Democratic parties and one Republican party, addressing family caregiver issues in their party platforms. © 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society.

  3. 49 CFR 1108.13 - Additional parties per side.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 8 2014-10-01 2014-10-01 false Additional parties per side. 1108.13 Section 1108.13 Transportation Other Regulations Relating to Transportation (Continued) SURFACE TRANSPORTATION... STATUTORY JURISDICTION OF THE SURFACE TRANSPORTATION BOARD § 1108.13 Additional parties per side. Where an...

  4. 49 CFR 1108.13 - Additional parties per side.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 8 2013-10-01 2013-10-01 false Additional parties per side. 1108.13 Section 1108.13 Transportation Other Regulations Relating to Transportation (Continued) SURFACE TRANSPORTATION... STATUTORY JURISDICTION OF THE SURFACE TRANSPORTATION BOARD § 1108.13 Additional parties per side. Where an...

  5. 16 CFR 1061.10 - Information on affected parties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Information on affected parties. 1061.10 Section 1061.10 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL APPLICATIONS FOR EXEMPTION FROM PREEMPTION § 1061.10 Information on affected parties. An application for an exemption from...

  6. 29 CFR 1425.6 - Use of third-party mediation assistance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Use of third-party mediation assistance. 1425.6 Section 1425.6 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE MEDIATION ASSISTANCE IN THE FEDERAL SERVICE § 1425.6 Use of third-party mediation assistance. If the parties...

  7. Two-party secret key distribution via a modified quantum secret sharing protocol.

    PubMed

    Grice, W P; Evans, P G; Lawrie, B; Legré, M; Lougovski, P; Ray, W; Williams, B P; Qi, B; Smith, A M

    2015-03-23

    We present and demonstrate a novel protocol for distributing secret keys between two and only two parties based on N-party single-qubit Quantum Secret Sharing (QSS). We demonstrate our new protocol with N = 3 parties using phase-encoded photons. We show that any two out of N parties can build a secret key based on partial information from each other and with collaboration from the remaining N - 2 parties. Our implementation allows for an accessible transition between N-party QSS and arbitrary two party QKD without modification of hardware. In addition, our approach significantly reduces the number of resources such as single photon detectors, lasers and dark fiber connections needed to implement QKD.

  8. Effects and outcomes of third-party reproduction: parents.

    PubMed

    Greenfeld, Dorothy A

    2015-09-01

    Third-party reproduction has introduced a host of changing family constellations. Research has shown that children conceived through third-party reproduction are doing well psychologically and developmentally, but what about their parents? How have they coped with the transition to third-party reproduction? Has the experience impacted their marital stability or the quality of their parenting? This review will address parents of children conceived through oocyte donation, parents of children conceived through gestational surrogacy, and gay male parents of children conceived through oocyte donation and gestational surrogacy. Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  9. 'Party Line' Information Use Studies and Implications for ATV Datalink Communications

    NASA Technical Reports Server (NTRS)

    Pritchett, Amy; Hansman, R. John; Midkiff, Alan

    1995-01-01

    The perceived importance and utilization of 'party line' information by air carrier flight crews was investigated through pilot surveys and a flight simulation study. The Importance, Availability, and Accuracy of party line information elements were explored through surveys of pilots of several operational types. The survey identified numerous traffic and weather party line information elements which were considered important. These elements were scripted into a full-mission flight simulation which examined the utilization of party line information by studying subject responses to specific information element stimuli. The awareness of the different Party Line elements varied, and awareness was also affected by pilot workload. In addition, pilots were aware of some traffic information elements, but were reluctant to act on Party Line Information alone. Finally, the importance of party line information appears to be greatest for operations near or on the airport. This indicates that caution should be exercised when implementing datalink communications in tower and close-in terminal control sectors.

  10. Controlled mutual quantum entity authentication with an untrusted third party

    NASA Astrophysics Data System (ADS)

    Kang, Min-Sung; Heo, Jino; Hong, Chang-Ho; Yang, Hyung-Jin; Han, Sang-Wook; Moon, Sung

    2018-07-01

    We propose a quantum control entity mutual authentication protocol that can be executed in environments involving an untrusted third party. In general, the third party, referred to as Charlie, can be an entity such as a telephone company, server, financial company, or login webpage for a portal service. Most communication protocols controlled by third parties are vulnerable to internal attacks. In this study, we present two solutions that make use of an entanglement correlation checking method and random numbers against an internal attack by an untrusted third party.

  11. South Georgia Autograph Parties.

    ERIC Educational Resources Information Center

    Womack, Geneva H.

    1978-01-01

    The manager of the South Georgia College Bookstore describes several autograph parties used as a sales promotion technique. The planning process, including initial contacts with the guest authors, are discussed, and the schedules and events of the authors' visits are reviewed. (JMD)

  12. 42 CFR 426.418 - LCD record furnished to aggrieved party.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false LCD record furnished to aggrieved party. 426.418... COVERAGE DETERMINATIONS Review of an LCD § 426.418 LCD record furnished to aggrieved party. (a) Elements of a contractor's LCD record furnished to the aggrieved party. Except as provided in paragraph (b) of...

  13. 42 CFR 426.418 - LCD record furnished to aggrieved party.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false LCD record furnished to aggrieved party. 426.418... COVERAGE DETERMINATIONS Review of an LCD § 426.418 LCD record furnished to aggrieved party. (a) Elements of a contractor's LCD record furnished to the aggrieved party. Except as provided in paragraph (b) of...

  14. 42 CFR 426.418 - LCD record furnished to aggrieved party.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false LCD record furnished to aggrieved party. 426.418... COVERAGE DETERMINATIONS Review of an LCD § 426.418 LCD record furnished to aggrieved party. (a) Elements of a contractor's LCD record furnished to the aggrieved party. Except as provided in paragraph (b) of...

  15. 12 CFR 1780.27 - Request for document discovery from parties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Request for document discovery from parties... Proceedings § 1780.27 Request for document discovery from parties. (a) General rule. Any party may serve on... specify a reasonable time, place and manner for production and performing any related acts. In lieu of...

  16. 12 CFR 908.47 - Request for document discovery from parties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Request for document discovery from parties... § 908.47 Request for document discovery from parties. (a) General rule. Any party may serve on any other... time, place and manner for production and performing any related acts. In lieu of inspecting the...

  17. Unrelated cord blood transplantation in adults with myelodysplasia or secondary acute myeloblastic leukemia: a survey on behalf of Eurocord and CLWP of EBMT.

    PubMed

    Robin, M; Sanz, G F; Ionescu, I; Rio, B; Sirvent, A; Renaud, M; Carreras, E; Milpied, N; Mohty, M; Beguin, Y; Bordigoni, P; de Witte, T; Picardi, A; Purtill, D; Gluckman, E; Kroger, N; Rocha, V

    2011-01-01

    The aim of our study was to evaluate, through the Eurocord and European Group for Blood and Marrow Transplantation (EBMT) registries, outcomes and risk factors for outcomes in adult patients who underwent single or double unrelated cord blood transplantation (UCBT) for myelodysplastic syndrome (MDS) or secondary acute myeloblastic leukemia (sAML). A total of 180 adults with MDS (n=39) or sAML (n=69) were analyzed. Risk factors for outcomes were analyzed using the Fine and Gray method and the Cox model. Median age was 43 (18-72) years. In all, 77 patients (71%) received a single UCBT. Myeloablative conditioning regimen (MAC) was given to 57 (53%) patients. Median numbers of nucleated and CD34(+) cells at freezing were 3.6 × 10(7) and 1.1 × 10(5) kg. At 60 days, cumulative incidence of neutrophil recovery was 78±4% and was independently associated with the number of CD34(+) cells per kg (>1.1 × 10(5); P=0.005) and advanced disease status (blasts <5% at time of UCBT, P=0.016). A 2-year non-relapse mortality (NRM) was significantly higher after MAC (62 vs 34%; P=0.009). A 2-year disease-free-survival (DFS) and overall survival (OS) were 30 and 34%, respectively. In multivariate analysis, patients with high-risk disease (blasts >5% and International Prognostic scoring system (IPSS) intermediate-2 or high in MDS) had significant poorer DFS (hazard ratio (HR): 1.76; P=0.047). In spite of high NRM, these data indicate that UCBT is an acceptable alternative option to treat adults with high-risk MDS or sAML, without a suitable human leukocyte antigen (HLA)-matched donor.

  18. Selfish third parties act as peacemakers by transforming conflicts and promoting cooperation.

    PubMed

    Halevy, Nir; Halali, Eliran

    2015-06-02

    The tremendous costs of conflict have made humans resourceful not only at warfare but also at peacemaking. Although third parties have acted as peacemakers since the dawn of history, little is known about voluntary, informal third-party intervention in conflict. Here we introduce the Peacemaker Game, a novel experimental paradigm, to model and study the interdependence between disputants and third parties in conflict. In the game, two disputants choose whether to cooperate or compete and a third party chooses whether or not to intervene in the conflict. Intervention introduces side payments that transform the game disputants are playing; it also introduces risk for the third party by making it vulnerable to disputants' choices. Six experiments revealed three robust effects: (i) The mere possibility of third-party intervention significantly increases cooperation in interpersonal and intergroup conflicts; (ii) reducing the risk to third parties dramatically increases intervention rates, to everyone's benefit; and (iii) disputants' cooperation rates are consistently higher than third parties' intervention rates. These findings explain why, how, and when self-interested third parties facilitate peaceful conflict resolution.

  19. Party Secretaries in Chinese Higher Education Institutions, Who Are They?

    ERIC Educational Resources Information Center

    Jiang, Hua; Li, Xiaobin

    2012-01-01

    With approximately 30 million students the Chinese higher education system is the largest in the world. In every publicly funded institution there is a communist party secretary, however, little is known about these party secretaries. The purpose of the study was to understand who these people were. We collected data from 1,751 party secretaries…

  20. A Practical Guide to Preventing and Dispersing Underage Drinking Parties

    ERIC Educational Resources Information Center

    Pacific Institute for Research and Evaluation, 2011

    2011-01-01

    This guide describes the role of enforcement and community organizations or groups in preventing underage drinking parties and how to safely disperse them. It describes the problem of underage drinking, in general, and youth-drinking parties in particular. It provides step-by-step information on how to address underage drinking parties and how to…

  1. 38 CFR 17.106 - VA collection rules; third-party payers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... a veteran who is also a beneficiary under the third-party payer's plan. VA's right to recover or... prosecute legal proceedings against a third-party payer to enforce a right of the United States under 38 U.S... the terms and conditions of the third-party payer's plan. Patient care records will not be made...

  2. 38 CFR 17.106 - VA collection rules; third-party payers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... a veteran who is also a beneficiary under the third-party payer's plan. VA's right to recover or... prosecute legal proceedings against a third-party payer to enforce a right of the United States under 38 U.S... the terms and conditions of the third-party payer's plan. Patient care records will not be made...

  3. 29 CFR 1420.9 - FMCS deferral to parties' own private interest arbitration procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... regulations are a part of the Service's overall approach to implementing the health care amendments of 1974 in... to be flexible and to tailor its approach so as to accommodate the needs of the parties in the..., both unions and management, to take advantage of these and other options and to work with the Service...

  4. 29 CFR 1420.9 - FMCS deferral to parties' own private interest arbitration procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... regulations are a part of the Service's overall approach to implementing the health care amendments of 1974 in... to be flexible and to tailor its approach so as to accommodate the needs of the parties in the..., both unions and management, to take advantage of these and other options and to work with the Service...

  5. Economics of Third-Party Central Heating Plants to Supply the Army

    DTIC Science & Technology

    1992-01-01

    Third-Party Gas-Fired Boiler Economics 52 APPENDIX C: Third-Party Gas Turbine Cogeneration Economics ( PURPA ) 58 APPENDIX D: Government Gas Turbine...Turbine Cogeneration Economics (Installation and PURPA Purchase) 76 APPENDIX G: Checklist for Identifying Optimal Third-Party Projects and Bidders 82...of scale 37 4 Relative costs of thermal energy from third-party cogeneration plants (@ 4C/kWh PURPA payment) 38 5 Comparison of life-cycle costs for

  6. Catch rates relative to angler party size with implications for monitoring angler success

    USGS Publications Warehouse

    Miranda, L.E.

    2005-01-01

    Angler catch rates often are used to monitor angler success, assess the need for additional management actions, and evaluate the effectiveness of management practices. Potential linkages between catch rate and angler party size were examined to assess how party size might affect the use of catch rate as an index of angler success in recreational fisheries. Data representing 22,355 completed interviews conducted at access points in lakes and reservoirs throughout Mississippi during 1987-2003 were analyzed. Total party catch was not proportional to total party effort; thus, catch rate decreased as party size increased. Depending on the taxa targeted, the average catch rate per angler decreased 40-50% between parties of one and parties of two, although subsequent decreases were less substantial. Because party size accounted for a considerable portion of the variability in catch rate over time and space, failure to remove this variability weakens the manager's ability to detect differences or changes in catch rates. Therefore, the use of catch rates to monitor fisheries may be inappropriate unless party size is taken into account. Party size may influence the angler's ability to catch fish through a variety of processes, including partitioning a limited number of catchable fish among members of a party and party composition. When catch rates are used to estimate total catch rather than to index angler success, party size is not a concern.

  7. Statement of Work Third Party Algorithm Development and Evaluation of Detection of Liquid Explosives in Dual-Energy Digital Radiographic/TIP Ready X-ray Images - Public Version

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nekoogar, F; Martz, Jr., H E

    2009-09-23

    The purpose of this statement of work is for third party collaborators to train, validate and have Lawrence Livermore National Security, LLC (LLNS) evaluate algorithms to detect liquid threats in digital radiography (DR)/TIP Ready X-ray (TRX) images that will be provided by LLNS through the Transportation and Security Administration (TSA). LLNS will provide a set of images with threat(s) to determine detection rates and non-threat images from airports to determine false alarm rates. A key including a bounding box showing the locations of the threats and non-threats will be provided for the images. It is expected that the Subcontractor shallmore » use half of the images with their keys for training the algorithms and the other half shall be used for validation (third party evaluation) purposes. The Subcontractor shall not use the key to the second half of the data other than for the validation and reporting of the performance of its algorithm (not for training). The Subcontractor has 45 business days from the receipt of datasets and the Subcontract to: (1) Run their detection/classification algorithms on the data; (2) Deliver a final report describing their performance by generating Receiver Operator Characteristic (ROC) curves using their algorithm; and (3) Deliver a copy of the third party's executable software (already trained and validated by the datasets) to LLNL accompanied by a user manual. LLNS will evaluate the performance of the same algorithm on another separate set of data. LLNS evaluation of the Subcontractor's algorithm will be documented in a final report within 30 days of receiving the executable code. This report will be sent to TSA and the report may be disseminated to the Subcontract at TSA's discretion.« less

  8. Education Policies of Turkish Political Parties and Their Possible Effects on Economic Development

    ERIC Educational Resources Information Center

    Nartgun, Senay S.; Eren, Altay

    2007-01-01

    This study examines the educational policies of Turkish political parties and their possible effects on economic development. Document analysis method was used to investigate the principles of education policies under various party programs--namely, the Great Union Party, the Independent Turkey Party, the Justice and Development Party, the…

  9. The diurnal course of salivary alpha-amylase in nurses: an investigation of potential confounders and associations with stress.

    PubMed

    Wingenfeld, Katja; Schulz, Michael; Damkroeger, Annika; Philippsen, Christine; Rose, Matthias; Driessen, Martin

    2010-09-01

    In psychoneuroendocrinology research, salivary measures have become increasingly important. While several studies focus on determinants of salivary cortisol such as age, gender, and gynaecological variables, less research has focused on confounding variables of salivary alpha-amylase (sAA). In a large sample of nurses (N=215) we analyzed the impact of age, gender, intake of oral contraceptives, smoking, coffee consumption as well as psychological parameters, such as work stress and burnout, on basal diurnal sAA release. Saliva was collected at 07:00 h, 11:30 h, 17:30 h, and 20:00 h on a working day during early shift. Only gender could be identified to have an impact on sAA, with females having a more pronounced sAA increase over the course of the day. Whereas depression, anxiety, work stress and burnout were not associated with sAA, a small negative correlation between social difficulties, measured with the Chronic Stress Screening Scale, and sAA could be identified. Copyright (c) 2010 Elsevier B.V. All rights reserved.

  10. "Party Line" Information Use Studies and Implications for ATC Datalink Communications

    NASA Technical Reports Server (NTRS)

    Hansman, R. John; Pritchett, Amy; Midkiff, Alan

    1995-01-01

    The perceived importance and utilization of 'party line' information by air carrier flight crews was investigated through pilot surveys and a flight simulation study. The importance, availability, and accuracy of party line information elements were explored through surveys of pilots of several operational types. The survey identified numerous traffic and weather party line information elements which were considered important. These elements were scripted into a full-mission flight simulation which examined the utilization of party line information by studying subject responses to specific information element stimuli. The awareness of the different Party Line elements varied, and awareness was also affected by pilot workload. In addition, pilots were aware of some traffic information elements, but were reluctant to act on Party Line Information alone. Finally, the results of both the survey and the simulation indicated that the importance of party line information appeared to be greatest for operations near or on the airport. This indicates that caution should be exercised when implementing datalink communications in tower and close-in terminal control sectors.

  11. 42 CFR 430.76 - Parties to the hearing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Parties to the hearing. 430.76 Section 430.76 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Conformity of State Medicaid Plans and Practice to Federal Requirements § 430.76 Parties to the hearing. (a...

  12. 29 CFR 18.18 - Written interrogatories to parties.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false Written interrogatories to parties. 18.18 Section 18.18 Labor Office of the Secretary of Labor RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE THE OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.18 Written interrogatories to parties. (a...

  13. 29 CFR 18.18 - Written interrogatories to parties.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Written interrogatories to parties. 18.18 Section 18.18 Labor Office of the Secretary of Labor RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE THE OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.18 Written interrogatories to parties. (a...

  14. 29 CFR 18.18 - Written interrogatories to parties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Written interrogatories to parties. 18.18 Section 18.18 Labor Office of the Secretary of Labor RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE THE OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.18 Written interrogatories to parties. (a...

  15. 29 CFR 18.18 - Written interrogatories to parties.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Written interrogatories to parties. 18.18 Section 18.18 Labor Office of the Secretary of Labor RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE THE OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.18 Written interrogatories to parties. (a...

  16. 29 CFR 18.18 - Written interrogatories to parties.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Written interrogatories to parties. 18.18 Section 18.18 Labor Office of the Secretary of Labor RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE THE OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.18 Written interrogatories to parties. (a...

  17. Political party affiliation, political ideology and mortality

    PubMed Central

    Pabayo, Roman; Kawachi, Ichiro; Muennig, Peter

    2018-01-01

    Background Ecological and cross-sectional studies have indicated that conservative political ideology is associated with better health. Longitudinal analyses of mortality are needed because subjective assessments of ideology may confound subjective assessments of health, particularly in cross-sectional analyses. Methods Data were derived from the 2008 General Social Survey-National Death Index data set. Cox proportional analysis models were used to determine whether political party affiliation or political ideology was associated with time to death. Also, we attempted to identify whether self-reported happiness and self-rated health acted as mediators between political beliefs and time to death. Results In this analysis of 32 830 participants and a total follow-up time of 498 845 person-years, we find that political party affiliation and political ideology are associated with mortality. However, with the exception of independents (adjusted HR (AHR)=0.93, 95% CI 0.90 to 0.97), political party differences are explained by the participants’ underlying sociodemographic characteristics. With respect to ideology, conservatives (AHR=1.06, 95% CI 1.01 to 1.12) and moderates (AHR=1.06, 95% CI 1.01 to 1.11) are at greater risk for mortality during follow-up than liberals. Conclusions Political party affiliation and political ideology appear to be different predictors of mortality. PMID:25631861

  18. Device independence for two-party cryptography and position verification with memoryless devices

    NASA Astrophysics Data System (ADS)

    Ribeiro, Jérémy; Thinh, Le Phuc; Kaniewski, Jedrzej; Helsen, Jonas; Wehner, Stephanie

    2018-06-01

    Quantum communication has demonstrated its usefulness for quantum cryptography far beyond quantum key distribution. One domain is two-party cryptography, whose goal is to allow two parties who may not trust each other to solve joint tasks. Another interesting application is position-based cryptography whose goal is to use the geographical location of an entity as its only identifying credential. Unfortunately, security of these protocols is not possible against an all powerful adversary. However, if we impose some realistic physical constraints on the adversary, there exist protocols for which security can be proven, but these so far relied on the knowledge of the quantum operations performed during the protocols. In this work we improve the device-independent security proofs of Kaniewski and Wehner [New J. Phys. 18, 055004 (2016), 10.1088/1367-2630/18/5/055004] for two-party cryptography (with memoryless devices) and we add a security proof for device-independent position verification (also memoryless devices) under different physical constraints on the adversary. We assess the quality of the devices by observing a Bell violation, and, as for Kaniewski and Wehner [New J. Phys. 18, 055004 (2016), 10.1088/1367-2630/18/5/055004], security can be attained for any violation of the Clauser-Holt-Shimony-Horne inequality.

  19. The willingness to pay of parties to traffic accidents for loss of productivity and consolation compensation.

    PubMed

    Jou, Rong-Chang; Chen, Tzu-Ying

    2015-12-01

    In this study, willingness to pay (WTP) for loss of productivity and consolation compensation by parties to traffic accidents is investigated using the Tobit model. In addition, WTP is compared to compensation determined by Taiwanese courts. The modelling results showed that variables such as education, average individual monthly income, traffic accident history, past experience of severe traffic accident injuries, the number of working days lost due to a traffic accident, past experience of accepting compensation for traffic accident-caused productivity loss and past experience of accepting consolation compensation caused by traffic accidents have a positive impact on WTP. In addition, average WTP for these two accident costs were obtained. We found that parties to traffic accidents were willing to pay more than 90% of the compensation determined by the court in the scenario of minor and moderate injuries. Parties were willing to pay approximately 80% of the compensation determined by the court for severe injuries, disability and fatality. Therefore, related agencies can use our study findings as the basis for determining the compensation that parties should pay for productivity losses caused by traffic accidents of different types. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Third-Party Cooperation: How Reducing Material Involvement Enhances Contributions to the Public Good.

    PubMed

    Losecaat Vermeer, Annabel B; Heerema, Roeland L; Sanfey, Alan G

    2016-03-01

    Decisions to cooperate are often delegated to a third party. We examined whether cooperation differs when decisions are made for a third party compared with ourselves and specified which motives are important for third-party cooperation. Participants played multiple rounds of a public goods game (PGG). In Study 1, we varied personal involvement from high to low; participants played for themselves (Self), for themselves and a third party (Shared), and solely for a third party (Third Party). Participants contributed most when personal involvement was lowest (i.e., Third Party) and least when personal involvement was high (i.e., Self). Study 2 explored if social motives underlie third-party cooperation by comparing cooperation with social (human) and non-social (computer) group members. Reducing personal involvement in the PGG (i.e., Third Party) increased cooperation in social contexts compared with non-social contexts, indicating enhanced collective interest. Increased cooperation for a third party may result from taking the other's perspective, thereby increasing social norm preferences. © 2016 by the Society for Personality and Social Psychology, Inc.

  1. Immigration politics Italian style: the paradoxical behaviour of mainstream and populist parties.

    PubMed

    Perlmutter, T

    1996-01-01

    This article explores the role of electoral politics in managing immigration as a policy option in Italy. Italy was late in passing its first comprehensive immigration legislation (1990). A small, liberal party waged a campaign against the proposed immigration law. A party known for right-wing posturing did not mobilize against the law. These political postures were not anticipated by conventional wisdom. Conventional wisdom suggests that immigration should not be an electoral issue and that consensus solutions should be sought. It is argued that the Italian response supports the view that in a fragmented, multi-party system, minor parties will be more likely to mobilize. Two mass media studies were used as the basis for this article's analysis. The studies provide detailed evidence on party willingness to publicly discuss immigration and the ways the issues are framed. The Italian case illustrates the tendency for mainstream, pro-system parties to politicize the issue and extremist, anti-system parties to depoliticize it. The DC and PCI, as mass parties, behaved traditionally and supported moderately open immigration policies, but in closed forums. The minor parties had a stake in shifting electoral support, so the PSI took an outspoken stand and the PARI publicized its exclusion from the policy-making process and its support for more restrictive policies. It was the constituencies and the leadership structure that facilitated these strategies. The author differs from Betz's party analysis by arguing that party ideology may not be a useful guide for predicting stands on immigration, and that it is difficult to generalize about immigration.

  2. 45 CFR 79.13 - Parties to the hearing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Parties to the hearing. 79.13 Section 79.13 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.13 Parties to the hearing. (a) The parities to the hearing shall be the defendant and the authority...

  3. 15 CFR 748.5 - Parties to the transaction.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... parties may be entered on the application. The definitions, which also appear in part 772 of the EAR, are... definition of “exporter” in part 772 of the EAR. (b) Other party authorized to receive license. The person... purpose of effecting delivery of the items to the ultimate consignee. The intermediate consignee may be a...

  4. 15 CFR 748.5 - Parties to the transaction.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... parties may be entered on the application. The definitions, which also appear in part 772 of the EAR, are... definition of “exporter” in part 772 of the EAR. (b) Other party authorized to receive license. The person... items for the purpose of effecting delivery of the items to the ultimate consignee. The intermediate...

  5. 15 CFR 748.5 - Parties to the transaction.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... parties may be entered on the application. The definitions, which also appear in part 772 of the EAR, are... definition of “exporter” in part 772 of the EAR. (b) Other party authorized to receive license. The person... items for the purpose of effecting delivery of the items to the ultimate consignee. The intermediate...

  6. 15 CFR 748.5 - Parties to the transaction.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... parties may be entered on the application. The definitions, which also appear in part 772 of the EAR, are... definition of “exporter” in part 772 of the EAR. (b) Other party authorized to receive license. The person... purpose of effecting delivery of the items to the ultimate consignee. The intermediate consignee may be a...

  7. Selfish third parties act as peacemakers by transforming conflicts and promoting cooperation

    PubMed Central

    Halevy, Nir; Halali, Eliran

    2015-01-01

    The tremendous costs of conflict have made humans resourceful not only at warfare but also at peacemaking. Although third parties have acted as peacemakers since the dawn of history, little is known about voluntary, informal third-party intervention in conflict. Here we introduce the Peacemaker Game, a novel experimental paradigm, to model and study the interdependence between disputants and third parties in conflict. In the game, two disputants choose whether to cooperate or compete and a third party chooses whether or not to intervene in the conflict. Intervention introduces side payments that transform the game disputants are playing; it also introduces risk for the third party by making it vulnerable to disputants’ choices. Six experiments revealed three robust effects: (i) The mere possibility of third-party intervention significantly increases cooperation in interpersonal and intergroup conflicts; (ii) reducing the risk to third parties dramatically increases intervention rates, to everyone’s benefit; and (iii) disputants’ cooperation rates are consistently higher than third parties’ intervention rates. These findings explain why, how, and when self-interested third parties facilitate peaceful conflict resolution. PMID:26038546

  8. Partisan Bias in Message Selection: Media Gatekeeping of Party Press Releases

    PubMed Central

    Haselmayer, Martin; Wagner, Markus; Meyer, Thomas M.

    2017-01-01

    Parties try to shape media coverage in ways that are favorable to them, but what determines whether media outlets pick up and report on party messages? Based on content analyses of 1,496 party press releases and 6,512 media reports from the 2013 Austrian parliamentary election campaign, we show that media coverage of individual party messages is influenced not just by news factors, but also by partisan bias. The media are therefore more likely to report on messages from parties their readers favor. Importantly, this effect is greater rather than weaker when these messages have high news value. These findings have important implications for understanding the media’s role in elections and representative democracies in general. PMID:29170614

  9. Prediction of Hematopoietic Stem Cell Transplantation Related Mortality- Lessons Learned from the In-Silico Approach: A European Society for Blood and Marrow Transplantation Acute Leukemia Working Party Data Mining Study.

    PubMed

    Shouval, Roni; Labopin, Myriam; Unger, Ron; Giebel, Sebastian; Ciceri, Fabio; Schmid, Christoph; Esteve, Jordi; Baron, Frederic; Gorin, Norbert Claude; Savani, Bipin; Shimoni, Avichai; Mohty, Mohamad; Nagler, Arnon

    2016-01-01

    Models for prediction of allogeneic hematopoietic stem transplantation (HSCT) related mortality partially account for transplant risk. Improving predictive accuracy requires understating of prediction limiting factors, such as the statistical methodology used, number and quality of features collected, or simply the population size. Using an in-silico approach (i.e., iterative computerized simulations), based on machine learning (ML) algorithms, we set out to analyze these factors. A cohort of 25,923 adult acute leukemia patients from the European Society for Blood and Marrow Transplantation (EBMT) registry was analyzed. Predictive objective was non-relapse mortality (NRM) 100 days following HSCT. Thousands of prediction models were developed under varying conditions: increasing sample size, specific subpopulations and an increasing number of variables, which were selected and ranked by separate feature selection algorithms. Depending on the algorithm, predictive performance plateaued on a population size of 6,611-8,814 patients, reaching a maximal area under the receiver operator characteristic curve (AUC) of 0.67. AUCs' of models developed on specific subpopulation ranged from 0.59 to 0.67 for patients in second complete remission and receiving reduced intensity conditioning, respectively. Only 3-5 variables were necessary to achieve near maximal AUCs. The top 3 ranking variables, shared by all algorithms were disease stage, donor type, and conditioning regimen. Our findings empirically demonstrate that with regards to NRM prediction, few variables "carry the weight" and that traditional HSCT data has been "worn out". "Breaking through" the predictive boundaries will likely require additional types of inputs.

  10. Manipulating Morality: Third-Party Intentions Alter Moral Judgments by Changing Causal Reasoning.

    PubMed

    Phillips, Jonathan; Shaw, Alex

    2015-08-01

    The present studies investigate how the intentions of third parties influence judgments of moral responsibility for other agents who commit immoral acts. Using cases in which an agent acts under some situational constraint brought about by a third party, we ask whether the agent is blamed less for the immoral act when the third party intended for that act to occur. Study 1 demonstrates that third-party intentions do influence judgments of blame. Study 2 finds that third-party intentions only influence moral judgments when the agent's actions precisely match the third party's intention. Study 3 shows that this effect arises from changes in participants' causal perception that the third party was controlling the agent. Studies 4 and 5, respectively, show that the effect cannot be explained by changes in the distribution of blame or perceived differences in situational constraint faced by the agent. © 2014 Cognitive Science Society, Inc.

  11. The Behaviour of Fe Stable Isotopes Accompanying Fluid Migration in Subducted Serpentinite from the Zermatt-Saas Ophiolite of the Swiss Alps

    NASA Astrophysics Data System (ADS)

    Inglis, E.; Bouilhol, P.; Burton, K. W.; Debret, B.; Millet, M. A.; Williams, H. M.

    2016-12-01

    During subduction the destabilisation of hydrous serpentine group phases can generate significant fluid fluxes between the subducting slab and the overlying mantle wedge. Despite our knowledge of this, the exact process and nature of the fluids released during serpentinite devolatilisation remain poorly understood. This study presents new field observations alongside petrographic and geochemical data for metamorphic veins and host serpentinite from the Zermatt-Saas ophiolite from the Swiss Alps, which underwent high-pressure metamorphism during the Alpine orogeny. Samples were collected from the serpentinised ultramafic section of the Zermatt-Saas ophiolite, which is mainly comprised of variably foliated and sheared antigorite serpentine. High-pressure metamorphic veins hosted within the antigorite serpentinite, are observed within the least deformed part of the massif, occurring as cm scale laterally continuous channels or mm scale interconnected anastomosing networks. Preliminary high-precision Fe isotope data for the host antigorite serpentine yield a mean δ56Fe value of -0.09‰ ± 0.04‰ (n=3), notably lighter than previously measured Alpine and abyssal serpentinites (Debret et al., 2016). In contrast, samples of cm scale olivine-bearing veins display a mean δ56Fe value of 0.07 ± 0.05‰ (n=3), resolvably heavier than that of the host serpentinite. These preliminary results suggest preferential mobility of isotopically heavy Fe within the vein forming fluids, but at this stage it is unclear if this fluid is related to local devolatilisation of the host serpentinite or input from an external source. Debret et al., 2016. Isotopic evidence for iron mobility during subduction. Geology, v. 44, no. 3, pp. 215 -218.

  12. 29 CFR 1404.12 - Selection by parties and appointments of arbitrators.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...: (1) A selection by mutual agreement; (2) A selection in which each party alternately strikes a name... 29 Labor 4 2010-07-01 2010-07-01 false Selection by parties and appointments of arbitrators. 1404... SERVICE ARBITRATION SERVICES Procedures for Arbitration Services § 1404.12 Selection by parties and...

  13. First-trimester maternal serum alpha-fetoprotein as a marker for fetal chromosomal disorders. Dutch Working Party on Prenatal Diagnosis.

    PubMed

    Van Lith, J M

    1994-10-01

    We evaluated first-trimester maternal serum alpha-fetoprotein (MS-AFP) as a marker for fetal chromosomal disorders. The multicentre study was performed under the auspices of the Dutch Working Party on Prenatal Diagnosis. MS-AFP was measured in 2404 normal pregnancies and 72 chromosomally abnormal pregnancies. The median multiple of the normal median (MOM) in 32 Down's syndrome pregnancies was 0.83 with a 95 per cent confidence interval ranging from 0.60 to 1.04. The difference between the distributions of first-trimester MS-AFP in normal and Down's syndrome pregnancies was statistically significant (t-test: t = 2.34, P < 0.05). Thirty-one per cent of the Down's syndrome pregnancies were found below the tenth percentile. We found no difference between normal pregnancies and pregnancies with other chromosomal disorders (eight cases with trisomy 18, MOM = 1.26; seven cases with sex chromosome abnormalities, MOM = 1.07; 22 cases with a chromosomal mosaic pattern in chorionic villi, MOM = 1.08). We conclude that first-trimester MS-AFP can discriminate between normal and Down's syndrome pregnancies, but is not an effective marker. First-trimester MS-AFP has no value as a marker for other fetal chromosomal disorders.

  14. A novel quantum scheme for secure two-party distance computation

    NASA Astrophysics Data System (ADS)

    Peng, Zhen-wan; Shi, Run-hua; Zhong, Hong; Cui, Jie; Zhang, Shun

    2017-12-01

    Secure multiparty computational geometry is an essential field of secure multiparty computation, which computes a computation geometric problem without revealing any private information of each party. Secure two-party distance computation is a primitive of secure multiparty computational geometry, which computes the distance between two points without revealing each point's location information (i.e., coordinate). Secure two-party distance computation has potential applications with high secure requirements in military, business, engineering and so on. In this paper, we present a quantum solution to secure two-party distance computation by subtly using quantum private query. Compared to the classical related protocols, our quantum protocol can ensure higher security and better privacy protection because of the physical principle of quantum mechanics.

  15. A Week Is a Long Time in Politics: The Health Implications of Jeremy Corbyn's UK Labour Party Leadership Victory.

    PubMed

    Scott-Samuel, Alex; Bambra, Clare

    2016-01-01

    For more than 30 years, socialism within the UK Labour Party - which was in government from 1997 to 2010 and is currently the main UK parliamentary opposition - has been in decline. Despite its origins as a party of and for the working class, Labour has become at best a social democratic party with strong neoliberal leanings. However, in the recent leadership election that followed Labour's general election defeat in May 2015, the socialist Jeremy Corbyn confounded all expectations by winning Labour's leadership with a substantial majority. We describe the political context of Corbyn's controversial victory and discuss its potential short- and medium-term impact on England's troubled National Health Service and on the public health. © The Author(s) 2015.

  16. Password-only authenticated three-party key exchange proven secure against insider dictionary attacks.

    PubMed

    Nam, Junghyun; Choo, Kim-Kwang Raymond; Paik, Juryon; Won, Dongho

    2014-01-01

    While a number of protocols for password-only authenticated key exchange (PAKE) in the 3-party setting have been proposed, it still remains a challenging task to prove the security of a 3-party PAKE protocol against insider dictionary attacks. To the best of our knowledge, there is no 3-party PAKE protocol that carries a formal proof, or even definition, of security against insider dictionary attacks. In this paper, we present the first 3-party PAKE protocol proven secure against both online and offline dictionary attacks as well as insider and outsider dictionary attacks. Our construct can be viewed as a protocol compiler that transforms any 2-party PAKE protocol into a 3-party PAKE protocol with 2 additional rounds of communication. We also present a simple and intuitive approach of formally modelling dictionary attacks in the password-only 3-party setting, which significantly reduces the complexity of proving the security of 3-party PAKE protocols against dictionary attacks. In addition, we investigate the security of the well-known 3-party PAKE protocol, called GPAKE, due to Abdalla et al. (2005, 2006), and demonstrate that the security of GPAKE against online dictionary attacks depends heavily on the composition of its two building blocks, namely a 2-party PAKE protocol and a 3-party key distribution protocol.

  17. Password-Only Authenticated Three-Party Key Exchange Proven Secure against Insider Dictionary Attacks

    PubMed Central

    Nam, Junghyun; Choo, Kim-Kwang Raymond

    2014-01-01

    While a number of protocols for password-only authenticated key exchange (PAKE) in the 3-party setting have been proposed, it still remains a challenging task to prove the security of a 3-party PAKE protocol against insider dictionary attacks. To the best of our knowledge, there is no 3-party PAKE protocol that carries a formal proof, or even definition, of security against insider dictionary attacks. In this paper, we present the first 3-party PAKE protocol proven secure against both online and offline dictionary attacks as well as insider and outsider dictionary attacks. Our construct can be viewed as a protocol compiler that transforms any 2-party PAKE protocol into a 3-party PAKE protocol with 2 additional rounds of communication. We also present a simple and intuitive approach of formally modelling dictionary attacks in the password-only 3-party setting, which significantly reduces the complexity of proving the security of 3-party PAKE protocols against dictionary attacks. In addition, we investigate the security of the well-known 3-party PAKE protocol, called GPAKE, due to Abdalla et al. (2005, 2006), and demonstrate that the security of GPAKE against online dictionary attacks depends heavily on the composition of its two building blocks, namely a 2-party PAKE protocol and a 3-party key distribution protocol. PMID:25309956

  18. Highs and lows: patterns of use, positive and negative effects of benzylpiperazine-containing party pills (BZP-party pills) amongst young people in New Zealand.

    PubMed

    Butler, Rachael A; Sheridan, Janie L

    2007-11-19

    This study aimed to investigate patterns and context of use of BZP-party pills, function of use, and positive and negative effects experienced by a sample of New Zealand young people who had used the products. A qualitative study comprised of semi-structured interviews and group discussions. The sample included 58 young people aged 17-23 years who had used BZP-party pills in the previous 12 months. Young people were using these substances in a range of settings--primarily during weekend social occasions--particularly as part of the dance party culture. They were mostly used for their stimulant properties and to enhance socialisation, and were often taken in combination with other legal and illicit drugs. Young people had suffered a range of physical and emotional negative effects, although none of these was reported as being life-threatening or long-term. Many participants had reduced the frequency with which they used BZP-party pills due to adverse effects. Potentially risky behaviours identified included taking large doses, mixing BZP-party pills with alcohol and other substances, and driving whilst under the influence of BZP-party pills. Findings suggest that young people in this study were not suffering excessive or dangerous adverse effects. However, potentially risky use of these products raises the issue of the need for developing harm reduction interventions.

  19. Highs and lows: patterns of use, positive and negative effects of benzylpiperazine-containing party pills (BZP-party pills) amongst young people in New Zealand

    PubMed Central

    Butler, Rachael A; Sheridan, Janie L

    2007-01-01

    Background This study aimed to investigate patterns and context of use of BZP-party pills, function of use, and positive and negative effects experienced by a sample of New Zealand young people who had used the products. Methods A qualitative study comprised of semi-structured interviews and group discussions. Results The sample included 58 young people aged 17–23 years who had used BZP-party pills in the previous 12 months. Young people were using these substances in a range of settings – primarily during weekend social occasions – particularly as part of the dance party culture. They were mostly used for their stimulant properties and to enhance socialisation, and were often taken in combination with other legal and illicit drugs. Young people had suffered a range of physical and emotional negative effects, although none of these was reported as being life-threatening or long-term. Many participants had reduced the frequency with which they used BZP-party pills due to adverse effects. Potentially risky behaviours identified included taking large doses, mixing BZP-party pills with alcohol and other substances, and driving whilst under the influence of BZP-party pills. Conclusion Findings suggest that young people in this study were not suffering excessive or dangerous adverse effects. However, potentially risky use of these products raises the issue of the need for developing harm reduction interventions. PMID:18021425

  20. 12 CFR 269a.2 - Party in interest.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... employees, labor organization, or bank that will be or is directly affected by the resolution of any charge... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Party in interest. 269a.2 Section 269a.2 Banks... employees of a bank or that is or was recently a party to a collective bargaining agreement with a bank...

  1. Using Third-Party Inspectors in Building Energy Codes Enforcement in India

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yu, Sha; Evans, Meredydd; Kumar, Pradeep

    human resources available in the state and local governments, involving third-party inspectors could rapidly expand the capacity for plan reviews and broad implementation. However, the procedures of involving third-parties need to be carefully designed in order to guarantee a fair process. For example, there should be multiple checks and certification requirements for third-party inspectors, and the government should have the final approval when third-party inspectors are used in a project. This paper discusses different approaches of involving third-parties in ECBC enforcement; the Indian states may choose the approaches that work best in their given circumstances.« less

  2. Newly identified poor prognostic factors for adult T-cell leukemia-lymphoma treated with allogeneic hematopoietic stem cell transplantation.

    PubMed

    Tokunaga, Masahito; Uto, Hirofumi; Takeuchi, Shogo; Nakano, Nobuaki; Kubota, Ayumu; Tokunaga, Mayumi; Takatsuka, Yoshifusa; Seto, Masao; Ido, Akio; Utsunomiya, Atae

    2017-01-01

    To explore pre-transplantation prognostic factors for adult T-cell leukemia-lymphoma (ATL), we retrospectively analyzed allogeneic hematopoietic stem cell transplantation (allo-HSCT) in 70 patients at our institute (63 acute type and seven lymphoma type patients). Forty-five patients died after HSCT and the three-year overall survival (OS) rate was 35.2%. By univariate analysis, the adverse prognostic factors for OS were performance status ≥2, hematopoietic cell transplantation-specific comorbidity index (HCT-CI) score ≥3, European Group for Blood and Marrow Transplantation (EBMT) risk score ≥5, HSCT from an HLA-mismatched donor, serum soluble interleukin-2 receptor (sIL-2R) level ≥10,000 U/mL, lymphocyte count ≥4000/μL, and hemoglobin <9 g/dL at the time of HSCT. EBMT risk score and sIL-2R were identified as significant adverse prognostic factors using multivariate analysis. This analysis clearly demonstrates for the first time that HCT-CI and EBMT risk scores are reliable prognostic factors for ATL patients receiving allo-HSCT.

  3. School Leadership and Citizenship Education: The Experiences and Struggles of School Party Secretaries in China

    ERIC Educational Resources Information Center

    Xu, Shuqin; Law, Wing-Wah

    2015-01-01

    Many scholarly works have examined school leadership, and many others have studied models for teaching citizenship education. Research combining both school leadership and citizenship education, however, is rare. The leadership of China's school party secretaries (SPSs), who are the equivalent of school principals in the Chinese school system and…

  4. 12 CFR 7.2014 - Indemnification of institution-affiliated parties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., or the relevant provisions of the Model Business Corporation Act (1984, as amended 1994, and as... parties. (a) Administrative proceedings or civil actions initiated by Federal banking agencies. A national... agency, a national bank may indemnify an institution-affiliated party for damages and expenses, including...

  5. ABO incompatibility in mismatched unrelated donor allogeneic hematopoietic cell transplantation for acute myeloid leukemia: A report from the acute leukemia working party of the EBMT.

    PubMed

    Canaani, Jonathan; Savani, Bipin N; Labopin, Myriam; Michallet, Mauricette; Craddock, Charles; Socié, Gerard; Volin, Lisa; Maertens, Johan A; Crawley, Charles; Blaise, Didier; Ljungman, Per T; Cornelissen, Jan; Russell, Nigel; Baron, Frédéric; Gorin, Norbert; Esteve, Jordi; Ciceri, Fabio; Schmid, Christoph; Giebel, Sebastian; Mohty, Mohamad; Nagler, Arnon

    2017-08-01

    ABO incompatibility is commonly observed in stem cell transplantation and its impact in this setting has been extensively investigated. HLA-mismatched unrelated donors (MMURD) are often used as an alternative stem cell source but are associated with increased transplant related complications. Whether ABO incompatibility affects outcome in MMURD transplantation for acute myeloid leukemia (AML) patients is unknown. We evaluated 1,013 AML patients who underwent MMURD transplantation between 2005 and 2014. Engraftment rates were comparable between ABO matched and mismatched patients, as were relapse incidence [34%; 95% confidence interval (CI), 28-39; for ABO matched vs. 36%; 95% CI, 32-40; for ABO mismatched; P = .32], and nonrelapse mortality (28%; 95% CI, 23-33; for ABO matched vs. 25%; 95% CI, 21-29; for ABO mismatched; P = .2). Three year survival was 40% for ABO matched and 43% for ABO mismatched patients (P = .35), Leukemia free survival rates were also comparable between groups (37%; 95% CI, 32-43; for ABO matched vs. 38%; 95% CI, 33-42; for ABO mismatched; P = .87). Incidence of grade II-IV acute graft versus host disease was marginally lower in patients with major ABO mismatching (Hazard ratio of 0.7, 95% CI, 0.5-1; P = .049]. ABO incompatibility probably has no significant clinical implications in MMURD transplantation. © 2017 Wiley Periodicals, Inc.

  6. Tonsillectomy and adenoidectomy in children with sleep-related breathing disorders: consensus statement of a UK multidisciplinary working party.

    PubMed

    Robb, P J; Bew, S; Kubba, H; Murphy, N; Primhak, R; Rollin, A-M; Tremlett, M

    2009-07-01

    During 2008, ENT-UK received a number of professional enquiries from colleagues about the management of children with upper airway obstruction and uncomplicated obstructive sleep apnoea (OSA). These children with sleep-related breathing disorders (SRBDs) are usually referred to paediatricians and ENT surgeons. In some district general hospitals, (DGHs) where paediatric intensive care (PICU) facilities to ventilate children were not available, paediatrician and anaesthetist colleagues were expressing concern about children with a clinical diagnosis of OSA having routine tonsillectomy, with or without adenoidectomy. As BAPO President, I was asked by the ENT-UK President, Professor Richard Ramsden, to investigate the issues and rapidly develop a working consensus statement to support safe but local treatment of these children. The Royal Colleges of Anaesthetists and Paediatrics and Child Health and the Association of Paediatric Anaesthetists nominated expert members from both secondary and tertiary care to contribute and develop a consensus statement based on the limited evidence base available. Our terms of reference were to produce a statement that was brief, with a limited number of references, to inform decision-making at the present time. With patient safety as the first priority, the working party wished to support practice that facilitated referral to a tertiary centre of those children who could be expected, on clinical assessment alone, potentially to require PICU facilities. In contrast, the majority of children who could be safely managed in a secondary care setting should be managed closer to home in a DGH. BAPO, ENT-UK, APA, RCS-CSF and RCoA have endorsed the consensus statement; the RCPCH has no mechanism for endorsing consensus statements, but the RCPCH Clinical Effectiveness Committee reviewed the statement, concluding it was a 'concise, accurate and helpful document'. The consensus statement is an interim working tool, based on level-five evidence. It

  7. 40 CFR Appendix E to Subpart A of... - Article 5 Parties

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Article 5 Parties E Appendix E to... Appendix E to Subpart A OF Part 82—Article 5 Parties Parties operating under Article 5 of the Montreal... categorized as Article 5 pending submission of ODS consumption data [79 FR 16687, Mar. 26, 2014] ...

  8. 42 CFR 426.518 - NCD record furnished to the aggrieved party.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false NCD record furnished to the aggrieved party. 426... LOCAL COVERAGE DETERMINATIONS Review of an NCD § 426.518 NCD record furnished to the aggrieved party. (a) Elements of the NCD record furnished to the aggrieved party. Except as provided in paragraph (b) of this...

  9. 42 CFR 426.518 - NCD record furnished to the aggrieved party.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false NCD record furnished to the aggrieved party. 426... LOCAL COVERAGE DETERMINATIONS Review of an NCD § 426.518 NCD record furnished to the aggrieved party. (a) Elements of the NCD record furnished to the aggrieved party. Except as provided in paragraph (b) of this...

  10. 42 CFR 426.518 - NCD record furnished to the aggrieved party.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false NCD record furnished to the aggrieved party. 426... LOCAL COVERAGE DETERMINATIONS Review of an NCD § 426.518 NCD record furnished to the aggrieved party. (a) Elements of the NCD record furnished to the aggrieved party. Except as provided in paragraph (b) of this...

  11. Unconditionally secure multi-party quantum commitment scheme

    NASA Astrophysics Data System (ADS)

    Wang, Ming-Qiang; Wang, Xue; Zhan, Tao

    2018-02-01

    A new unconditionally secure multi-party quantum commitment is proposed in this paper by encoding the committed message to the phase of a quantum state. Multi-party means that there are more than one recipient in our scheme. We show that our quantum commitment scheme is unconditional hiding and binding, and hiding is perfect. Our technique is based on the interference of phase-encoded coherent states of light. Its security proof relies on the no-cloning theorem of quantum theory and the properties of quantum information.

  12. The Chinese Communist Party: A Strategic Center of Gravity Analysis

    DTIC Science & Technology

    2012-03-08

    Party (CCP or the Party) recently celebrated its 90th anniversary, trumpeting China‘s notable progress in their quest to rejuvenate a transcendent...will be ―first-timers‖ due mainly to the CCP‘s mandatory age of retirement at 65 years of age . 47 Of significance, lower-party elections will result...Kim Jong Il) can prove highly stable. Yet, as dictators age , or as populations grow richer and more anxious to share in political power, autocracies

  13. 49 CFR 1007.6 - Disclosure to third parties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Disclosure to third parties. 1007.6 Section 1007.6... § 1007.6 Disclosure to third parties. (a) The Board shall not disclose to any agency or to any person by... Information Act (5 U.S.C. 552). (4) Disclosure is for a routine use as defined in § 1007.2 of these rules and...

  14. How does single party dominance influence civil society organisations' engagement strategies? Exploratory analysis of participative mainstreaming in a 'regional' European polity.

    PubMed

    Chaney, Paul

    2016-04-01

    A raft of United Nations Treaties, European Union Directives and domestic laws oblige governments in 180 + countries to apply the Participative Democratic Model of mainstreaming equalities to public administration by involving those targeted by equality initiatives at all stages in their design and delivery. Notwithstanding Participative Democratic Model's deeply political nature, extant work has overlooked how governing party turnover influences civil society organisations' (CSOs) strategies. Here, this lacuna is addressed using a negative 'extreme case study' research design involving qualitative accounts from civil society organisations in Wales, a 'regional' European polity characterised by one-party dominance. The findings reveal how the absence of turnover distorts the Participative Democratic Model in relation to diverse factors including: strategic bridging, extraparliamentary politics, cognitive locks and party institutionalisation. Inter alia, the wider contribution of this analysis lies in showing the importance of turnover to effective engagement, the 'pathologies' associated with one-party dominance and the need for adaptive civil society strategies tailored to prevailing electoral politics and governing party turnover in liberal democracies.

  15. Maori Adult Education: Report of a Working Party.

    ERIC Educational Resources Information Center

    National Council of Adult Education, Wellington (New Zealand).

    Traditional preliterate Maori society had an integrated educational structure, later augmented by the work of various Maori and European organizations. Auckland University developed programs in Maori adult education in a bicultural setting, and recognition has evolved of the needs of Maori people for education in coping skills and in Maori…

  16. Confidentiality with respect to third parties: a psychoanalytic view.

    PubMed

    Furlong, Allannah

    2005-04-01

    It is assumed that confidentiality is not one singular ethical entity but a conglomerate of quite different issues depending upon clinical context and the sector of information sharing at stake. The focus here is on how to think psychoanalytically about requests for information from third parties (payers, courts, public security). Defining confidentiality as a promise to 'never tell anything' outside of the relationship omits evaluation of the impact of the third's listening on the combined freedom of thought and freedom of speech in analyst and analysand. Circulation of information outside the dyad need not be toxic, need not disrupt the analytic couple's openness to new meaning. Key to contamination and inhibition of analytic work is whether or not disclosure serves an analytic end. Current defense of confidentiality relies heavily on the models of protection of privacy and professional secrecy, which, though useful and relevant, fail to encompass the transitional, intersubjective space engendered by the analytic process. Suggestions are made for alternate sources of paradigms better suited to represent the latter. Offered for discussion is a draft of a confidentiality policy with respect to third parties that is informed by psychoanalytic theory and clinical practice rather than by local legal jurisdiction or original disciplines' ethics codes.

  17. 25 CFR 224.101 - Who is an interested party?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Who is an interested party? 224.101 Section 224.101 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Interested Party Petitions...

  18. 25 CFR 224.101 - Who is an interested party?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Who is an interested party? 224.101 Section 224.101 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Interested Party Petitions...

  19. Political party affiliation, political ideology and mortality.

    PubMed

    Pabayo, Roman; Kawachi, Ichiro; Muennig, Peter

    2015-05-01

    Ecological and cross-sectional studies have indicated that conservative political ideology is associated with better health. Longitudinal analyses of mortality are needed because subjective assessments of ideology may confound subjective assessments of health, particularly in cross-sectional analyses. Data were derived from the 2008 General Social Survey-National Death Index data set. Cox proportional analysis models were used to determine whether political party affiliation or political ideology was associated with time to death. Also, we attempted to identify whether self-reported happiness and self-rated health acted as mediators between political beliefs and time to death. In this analysis of 32,830 participants and a total follow-up time of 498,845 person-years, we find that political party affiliation and political ideology are associated with mortality. However, with the exception of independents (adjusted HR (AHR)=0.93, 95% CI 0.90 to 0.97), political party differences are explained by the participants' underlying sociodemographic characteristics. With respect to ideology, conservatives (AHR=1.06, 95% CI 1.01 to 1.12) and moderates (AHR=1.06, 95% CI 1.01 to 1.11) are at greater risk for mortality during follow-up than liberals. Political party affiliation and political ideology appear to be different predictors of mortality. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  20. Clinical features and treatment outcomes of Langerhans cell histiocytosis: a nationwide survey from Korea histiocytosis working party.

    PubMed

    Kim, Bo Eun; Koh, Kyung-Nam; Suh, Jin Kyung; Im, Ho Joon; Song, Joon Sup; Lee, Ji Won; Kang, Hyoung Jin; Park, Kyung Duck; Shin, Hee Young; Choi, Hyoung Soo; Lee, Soo Hyun; Yoo, Keon Hee; Sung, Ki Woong; Koo, Hong Hoe; Jung, Hye Lim; Chung, Nak-Gyun; Cho, Bin; Kim, Hack Ki; Lyu, Chuhl Joo; Baek, Hee Jo; Kook, Hoon; Park, Jun Eun; Park, Hyeon Jin; Park, Byung-Kiu; Yoo, Eun Sun; Ryu, Kyung Ha; Lee, Kun Soo; Kim, Heung Sik; Lee, Jae Min; Park, Eun Sil; Yoon, Hoi Soo; Lee, Kwang Chul; Lee, Mee Jeong; Lim, Young Tak; Kim, Hwang Min; Park, Sang Kyu; Park, Jeong-A; Kim, Soon Ki; Park, Meerim; Lim, Yeon-Jung; Lee, Young Ho; Seo, Jong Jin

    2014-03-01

    A nationwide survey was conducted to clarify the clinical features and outcomes of Korean children with Langerhans cell histiocytosis (LCH). Korea Histiocytosis Working Party analyzed the data of 603 patients who were diagnosed with LCH between 1986 and 2010 from 28 institutions in Korea. Median age at diagnosis was 65 months (range, 0 to 276 mo). Bone was the most frequently affected organ (79.6%) followed by skin (19.2%). Initially, 419 patients (69.5%) had single-system involvement (SS), 85 (14.1%) with multisystem (MS) disease without risk organ involvement (MS-RO), and 99 (16.4%) multisystem disease with risk organ involvement (MS-RO). The 5-year overall survival (OS) rates in the SS, MS-RO, and MS-RO groups were 99.8%, 98.4%, and 77.0%, respectively (P<0.001), and the 5-year reactivation rates were 17.9%, 33.5%, and 34.3%, respectively (P<0.001). The OS rate was lower in patients with RO involvement (P=0.025) and lack of response to initial treatment (P=0.001). MS involvement (P=0.036) was an independent risk factor for reactivation. Permanent consequences were documented in 99 patients (16.4%). Reactivation of disease, MS involvement, and age at diagnosis ≤ 2 years were associated with higher incidence of permanent consequences. This study emphasized that further efforts are required to improve survival of MS-RO patients and reduce reactivation in younger patients with MS involvement.

  1. 11 CFR 9004.2 - Pre-election payments for minor and new party candidates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Pre-election payments for minor and new party... § 9004.2 Pre-election payments for minor and new party candidates. (a) Candidate of a minor party in the preceding election. An eligible candidate of a minor party is entitled to pre-election payments: (1) If he...

  2. 11 CFR 9004.2 - Pre-election payments for minor and new party candidates.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 11 Federal Elections 1 2011-01-01 2011-01-01 false Pre-election payments for minor and new party... § 9004.2 Pre-election payments for minor and new party candidates. (a) Candidate of a minor party in the preceding election. An eligible candidate of a minor party is entitled to pre-election payments: (1) If he...

  3. 17 CFR 201.150 - Service of papers by parties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Service of papers by parties... PRACTICE Rules of Practice General Rules § 201.150 Service of papers by parties. (a) When required. In every proceeding as defined in § 201.101(a), each paper, including each notice of appearance, written...

  4. 17 CFR 201.150 - Service of papers by parties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Service of papers by parties... PRACTICE Rules of Practice General Rules § 201.150 Service of papers by parties. (a) When required. In every proceeding as defined in § 201.101(a), each paper, including each notice of appearance, written...

  5. Divergence over conformity: Change in immigration attitudes after the electoral success of an anti-immigration populist party in the Finnish 2015 parliamentary elections.

    PubMed

    Lönnqvist, Jan-Erik; Mannerström, Rasmus; Leikas, Sointu

    2018-06-05

    The populist, anti-immigration-oriented Finns Party was considered the winner of the Finnish 2015 parliamentary elections. In a representative sample of young adults (N = 606), a longitudinal pre- post-election design revealed that attitudes towards immigration became more favourable among those disappointed by the outcome and those who did not vote for the Finns Party. Among the latter, both supporting the green-red rival parties and disliking the Finns Party independently predicted increased support for migration. Other attitudes did not change. The results highlight the importance of social processes and identity concerns, particularly self-categorization, as drivers of attitude change. While previous work has focused on conformity dynamics, our results suggest that diverging from an unwanted identity may be associated with attitude change. © 2018 International Union of Psychological Science.

  6. Online network organization of Barcelona en Comú, an emergent movement-party.

    PubMed

    Aragón, Pablo; Gallego, Helena; Laniado, David; Volkovich, Yana; Kaltenbrunner, Andreas

    2017-01-01

    The emerging grassroots party Barcelona en Comú won the 2015 Barcelona City Council election. This candidacy was devised by activists involved in the Spanish 15M movement to transform citizen outrage into political change. On the one hand, the 15M movement was based on a decentralized structure. On the other hand, political science literature postulates that parties develop oligarchical leadership structures. This tension motivates to examine whether Barcelona en Comú preserved a decentralized structure or adopted a conventional centralized organization. In this study we develop a computational methodology to characterize the online network organization of every party in the election campaign on Twitter. Results on the network of retweets reveal that, while traditional parties are organized in a single cluster, for Barcelona en Comú two well-defined groups co-exist: a centralized cluster led by the candidate and party accounts, and a decentralized cluster with the movement activists. Furthermore, results on the network of replies also shows a dual structure: a cluster around the candidate receiving the largest attention from other parties, and another with the movement activists exhibiting a higher predisposition to dialogue with other parties.

  7. Costly third-party punishment in young children.

    PubMed

    McAuliffe, Katherine; Jordan, Jillian J; Warneken, Felix

    2015-01-01

    Human adults engage in costly third-party punishment of unfair behavior, but the developmental origins of this behavior are unknown. Here we investigate costly third-party punishment in 5- and 6-year-old children. Participants were asked to accept (enact) or reject (punish) proposed allocations of resources between a pair of absent, anonymous children. In addition, we manipulated whether subjects had to pay a cost to punish proposed allocations. Experiment 1 showed that 6-year-olds (but not 5-year-olds) punished unfair proposals more than fair proposals. However, children punished less when doing so was personally costly. Thus, while sensitive to cost, they were willing to sacrifice resources to intervene against unfairness. Experiment 2 showed that 6-year-olds were less sensitive to unequal allocations when they resulted from selfishness than generosity. These findings show that costly third-party punishment of unfair behavior is present in young children, suggesting that from early in development children show a sophisticated capacity to promote fair behavior. Copyright © 2014 Elsevier B.V. All rights reserved.

  8. 48 CFR 613.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Imprest funds and third party drafts. 613.305 Section 613.305 Federal Acquisition Regulations System DEPARTMENT OF STATE....305 Imprest funds and third party drafts. ...

  9. 48 CFR 613.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Imprest funds and third party drafts. 613.305 Section 613.305 Federal Acquisition Regulations System DEPARTMENT OF STATE....305 Imprest funds and third party drafts. ...

  10. 48 CFR 1313.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Imprest funds and third party drafts. 1313.305 Section 1313.305 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE....305 Imprest funds and third party drafts. ...

  11. 48 CFR 1313.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Imprest funds and third party drafts. 1313.305 Section 1313.305 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE....305 Imprest funds and third party drafts. ...

  12. 48 CFR 1313.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Imprest funds and third party drafts. 1313.305 Section 1313.305 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE....305 Imprest funds and third party drafts. ...

  13. 48 CFR 613.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Imprest funds and third party drafts. 613.305 Section 613.305 Federal Acquisition Regulations System DEPARTMENT OF STATE....305 Imprest funds and third party drafts. ...

  14. 48 CFR 613.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Imprest funds and third party drafts. 613.305 Section 613.305 Federal Acquisition Regulations System DEPARTMENT OF STATE....305 Imprest funds and third party drafts. ...

  15. 48 CFR 1313.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Imprest funds and third party drafts. 1313.305 Section 1313.305 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE....305 Imprest funds and third party drafts. ...

  16. 48 CFR 613.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Imprest funds and third party drafts. 613.305 Section 613.305 Federal Acquisition Regulations System DEPARTMENT OF STATE....305 Imprest funds and third party drafts. ...

  17. 48 CFR 1313.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Imprest funds and third party drafts. 1313.305 Section 1313.305 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE....305 Imprest funds and third party drafts. ...

  18. 34 CFR 81.19 - Costs and fees of parties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Costs and fees of parties. 81.19 Section 81.19 Education Office of the Secretary, Department of Education GENERAL EDUCATION PROVISIONS ACT-ENFORCEMENT General Provisions § 81.19 Costs and fees of parties. The Equal Access to Justice Act, 5 U.S.C. 504...

  19. 13 CFR 120.921 - Terms of Third Party loans.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Loan lender waives, as to the CDC/SBA financing, any provision in its deed of trust, or mortgage, or... Party Lender must give the CDC and SBA written notice of default within 30 days of the event of default... Third Party Lender's lien will be subordinate to the CDC/SBA lien regarding any prepayment penalties...

  20. 13 CFR 120.921 - Terms of Third Party loans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Loan lender waives, as to the CDC/SBA financing, any provision in its deed of trust, or mortgage, or... Party Lender must give the CDC and SBA written notice of default within 30 days of the event of default... Third Party Lender's lien will be subordinate to the CDC/SBA lien regarding any prepayment penalties...

  1. 13 CFR 120.921 - Terms of Third Party loans.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Loan lender waives, as to the CDC/SBA financing, any provision in its deed of trust, or mortgage, or... Party Lender must give the CDC and SBA written notice of default within 30 days of the event of default... Third Party Lender's lien will be subordinate to the CDC/SBA lien regarding any prepayment penalties...

  2. 13 CFR 120.921 - Terms of Third Party loans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Loan lender waives, as to the CDC/SBA financing, any provision in its deed of trust, or mortgage, or... Party Lender must give the CDC and SBA written notice of default within 30 days of the event of default... Third Party Lender's lien will be subordinate to the CDC/SBA lien regarding any prepayment penalties...

  3. 13 CFR 120.921 - Terms of Third Party loans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Loan lender waives, as to the CDC/SBA financing, any provision in its deed of trust, or mortgage, or... Party Lender must give the CDC and SBA written notice of default within 30 days of the event of default... Third Party Lender's lien will be subordinate to the CDC/SBA lien regarding any prepayment penalties...

  4. 26 CFR 1.7476-2 - Notice to interested parties.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... § 1.7476-1 shall cause notice of the application to be given to persons who qualify as interested parties under § 1.7476-1 with respect to the application, whether or not such application is received by... calculated to ensure that each interested party is notified of the application for a determination. If an...

  5. 26 CFR 1.7476-2 - Notice to interested parties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... § 1.7476-1 shall cause notice of the application to be given to persons who qualify as interested parties under § 1.7476-1 with respect to the application, whether or not such application is received by... calculated to ensure that each interested party is notified of the application for a determination. If an...

  6. 26 CFR 1.7476-2 - Notice to interested parties.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... § 1.7476-1 shall cause notice of the application to be given to persons who qualify as interested parties under § 1.7476-1 with respect to the application, whether or not such application is received by... calculated to ensure that each interested party is notified of the application for a determination. If an...

  7. 26 CFR 1.7476-2 - Notice to interested parties.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... § 1.7476-1 shall cause notice of the application to be given to persons who qualify as interested parties under § 1.7476-1 with respect to the application, whether or not such application is received by... calculated to ensure that each interested party is notified of the application for a determination. If an...

  8. 24 CFR 401.500 - Required notices to third parties and meeting with third parties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... submission to HUD, notice of the following must be provided: (i) The location of the Plan for inspection and... HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO-MARKET) Restructuring Plan § 401.500 Required notices to...) Access to Restructuring Plan. (1) The PAE must make the Restructuring Plan available to the parties...

  9. Third-party social evaluations of humans by monkeys and dogs.

    PubMed

    Anderson, James R; Bucher, Benoit; Chijiiwa, Hitomi; Kuroshima, Hika; Takimoto, Ayaka; Fujita, Kazuo

    2017-11-01

    Developmental psychologists are increasingly interested in young children's evaluations of individuals based on third-party interactions. Studies have shown that infants react negatively to agents who display harmful intentions toward others, and to those who behave unfairly. We describe experimental studies of capuchin monkeys' and pet dogs' differential reactions to people who are helpful or unhelpful in third-party contexts, and monkeys' responses to people who behave unfairly in exchanges of objects with a third party. We also present evidence that capuchin monkeys monitor the context of failures to help and violations of reciprocity, and that intentionality is one factor underlying their social evaluations of individuals whom they see interacting with others. We conclude by proposing some questions for studies of nonhuman species' third party-based social evaluations. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Party Characteristics, Drinking Settings, and College Students’ Risk of Intoxication: A Multi-Campus Study

    PubMed Central

    Marzell, Miesha; Bavarian, Niloofar; Paschall, Mallie J.; Mair, Christina; Saltz, Robert F.

    2015-01-01

    We examined party characteristics across different college drinking settings, associations between party characteristics and likelihood of drinking to intoxication, and the mediating role of perceived prevalence of intoxicated partygoers. Students (N = 6903) attending 14 public universities in California during the 2010 and 2011 fall semesters completed surveys on individual and party characteristics in six unique settings (e.g., residence hall). We used descriptive statistics to examine party characteristics by setting. We estimated multilevel logistic regression models to identify party characteristics associated with drinking to intoxication, and we used RMediation to determine significance of mediating effects. Individual and party characteristics varied by drinking context. Greater time at a party was associated with drinking to intoxication at five of six settings, while larger party size was significant only for outdoor settings. Enforcing the legal drinking age and refusing to serve intoxicated patrons were associated with lower likelihood of intoxication at Greek and off-campus parties. The presence of a keg was associated with drinking to intoxication at Greek, off-campus and outdoor parties; at bars, cover charges and drink promotions were positively associated with drinking to intoxication. In four of six settings, we found evidence of significant mediating effects through perceived prevalence of intoxicated partygoers. Findings highlight risk and protective characteristics of parties by drinking setting, and have prevention implications. PMID:25976418

  11. Party Characteristics, Drinking Settings, and College Students' Risk of Intoxication: A Multi-Campus Study.

    PubMed

    Marzell, Miesha; Bavarian, Niloofar; Paschall, Mallie J; Mair, Christina; Saltz, Robert F

    2015-08-01

    We examined party characteristics across different college drinking settings, associations between party characteristics and likelihood of drinking to intoxication, and the mediating role of perceived prevalence of intoxicated partygoers. Students (N = 6903) attending 14 public universities in California during the 2010 and 2011 fall semesters completed surveys on individual and party characteristics in six unique settings (e.g., residence hall). We used descriptive statistics to examine party characteristics by setting. We estimated multilevel logistic regression models to identify party characteristics associated with drinking to intoxication, and we used RMediation to determine significance of mediating effects. Individual and party characteristics varied by drinking context. Greater time at a party was associated with drinking to intoxication at five of six settings, while larger party size was significant only for outdoor settings. Enforcing the legal drinking age and refusing to serve intoxicated patrons were associated with lower likelihood of intoxication at Greek and off-campus parties. The presence of a keg was associated with drinking to intoxication at Greek, off-campus and outdoor parties; at bars, cover charges and drink promotions were positively associated with drinking to intoxication. In four of six settings, we found evidence of significant mediating effects through perceived prevalence of intoxicated partygoers. Findings highlight risk and protective characteristics of parties by drinking setting, and have prevention implications.

  12. How does single party dominance influence civil society organisations’ engagement strategies? Exploratory analysis of participative mainstreaming in a ‘regional’ European polity

    PubMed Central

    2015-01-01

    A raft of United Nations Treaties, European Union Directives and domestic laws oblige governments in 180 + countries to apply the Participative Democratic Model of mainstreaming equalities to public administration by involving those targeted by equality initiatives at all stages in their design and delivery. Notwithstanding Participative Democratic Model’s deeply political nature, extant work has overlooked how governing party turnover influences civil society organisations’ (CSOs) strategies. Here, this lacuna is addressed using a negative ‘extreme case study’ research design involving qualitative accounts from civil society organisations in Wales, a ‘regional’ European polity characterised by one-party dominance. The findings reveal how the absence of turnover distorts the Participative Democratic Model in relation to diverse factors including: strategic bridging, extraparliamentary politics, cognitive locks and party institutionalisation. Inter alia, the wider contribution of this analysis lies in showing the importance of turnover to effective engagement, the ‘pathologies’ associated with one-party dominance and the need for adaptive civil society strategies tailored to prevailing electoral politics and governing party turnover in liberal democracies. PMID:28596639

  13. Eavesdropping on the improved three-party quantum secret sharing protocol

    NASA Astrophysics Data System (ADS)

    Gao, Gan

    2011-02-01

    Lin et al. [Song Lin, Fei Gao, Qiao-yan Wen, Fu-chen Zhu, Opt. Commun. 281 (2008) 4553] pointed out that the multiparty quantum secret sharing protocol [Zhan-jun Zhang, Gan Gao, Xin Wang, Lian-fang Han, Shou-hua Shi, Opt. Commun. 269 (2007) 418] is not secure and proposed an improved three-party quantum secret sharing protocol. In this paper, we study the security of the improved three-party quantum secret sharing protocol and find that it is still not secure. Finally, a further improved three-party quantum secret sharing protocol is proposed.

  14. 48 CFR 13.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Imprest funds and third party drafts. 13.305 Section 13.305 Federal Acquisition Regulations System FEDERAL ACQUISITION... Methods 13.305 Imprest funds and third party drafts. ...

  15. 48 CFR 13.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Imprest funds and third party drafts. 13.305 Section 13.305 Federal Acquisition Regulations System FEDERAL ACQUISITION... Methods 13.305 Imprest funds and third party drafts. ...

  16. 48 CFR 13.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Imprest funds and third party drafts. 13.305 Section 13.305 Federal Acquisition Regulations System FEDERAL ACQUISITION... Methods 13.305 Imprest funds and third party drafts. ...

  17. 48 CFR 13.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Imprest funds and third party drafts. 13.305 Section 13.305 Federal Acquisition Regulations System FEDERAL ACQUISITION... Methods 13.305 Imprest funds and third party drafts. ...

  18. 48 CFR 13.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Imprest funds and third party drafts. 13.305 Section 13.305 Federal Acquisition Regulations System FEDERAL ACQUISITION... Methods 13.305 Imprest funds and third party drafts. ...

  19. Third party laboratory data management: Perspective with respect to clinical data management.

    PubMed

    Johnson, Jasmin; Kanagali, Vishwanath; Prabu, D

    2014-01-01

    Third party lab vendor provides support for laboratory, biological samples analytics data, collected during the clinical trial. Third party laboratory data is considered to be very significant for the clinical trial data management process. Although outsourcing these services is considered to be advantageous for clinical trials, there are some risks involved. Hence, pharmaceutical companies proactively select, track and evaluate third party vendors on a regular basis before, during and after the completion of the contract. The data manager has a significant role to play in effective management of third party vendor data.

  20. Third party laboratory data management: Perspective with respect to clinical data management

    PubMed Central

    Johnson, Jasmin; Kanagali, Vishwanath; Prabu, D.

    2014-01-01

    Third party lab vendor provides support for laboratory, biological samples analytics data, collected during the clinical trial. Third party laboratory data is considered to be very significant for the clinical trial data management process. Although outsourcing these services is considered to be advantageous for clinical trials, there are some risks involved. Hence, pharmaceutical companies proactively select, track and evaluate third party vendors on a regular basis before, during and after the completion of the contract. The data manager has a significant role to play in effective management of third party vendor data. PMID:24551587

  1. Intra-Campaign Changes in Voting Preferences: The Impact of Media and Party Communication

    PubMed Central

    Johann, David; Königslöw, Katharina Kleinen-von; Kritzinger, Sylvia; Thomas, Kathrin

    2018-01-01

    An increasing number of citizens change and adapt their party preferences during the electoral campaign. We analyze which short-term factors explain intra-campaign changes in voting preferences, focusing on the visibility and tone of news media reporting and party canvassing. Our analyses rely on an integrative data approach, linking data from media content analysis to public opinion data. This enables us to investigate the relative impact of news media reporting as well as party communication. Inherently, we overcome previously identified methodological problems in the study of communication effects on voting behavior. Our findings reveal that campaigns matter: Especially interpersonal party canvassing increases voters’ likelihood to change their voting preferences in favor of the respective party, whereas media effects are limited to quality news outlets and depend on individual voters’ party ambivalence. PMID:29695892

  2. Intra-Campaign Changes in Voting Preferences: The Impact of Media and Party Communication.

    PubMed

    Johann, David; Königslöw, Katharina Kleinen-von; Kritzinger, Sylvia; Thomas, Kathrin

    2018-01-01

    An increasing number of citizens change and adapt their party preferences during the electoral campaign. We analyze which short-term factors explain intra-campaign changes in voting preferences, focusing on the visibility and tone of news media reporting and party canvassing. Our analyses rely on an integrative data approach, linking data from media content analysis to public opinion data. This enables us to investigate the relative impact of news media reporting as well as party communication. Inherently, we overcome previously identified methodological problems in the study of communication effects on voting behavior. Our findings reveal that campaigns matter: Especially interpersonal party canvassing increases voters' likelihood to change their voting preferences in favor of the respective party, whereas media effects are limited to quality news outlets and depend on individual voters' party ambivalence.

  3. 47 CFR 1.21 - Parties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Parties. 1.21 Section 1.21 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE General Rules of Practice and Procedure... chapter, a duly authorized corporate officer or employee may act for the corporation in any matter which...

  4. 24 CFR 180.310 - Parties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Parties. 180.310 Section 180.310 Housing and Urban Development Regulations Relating to Housing and Urban Development OFFICE OF ASSISTANT SECRETARY FOR EQUAL OPPORTUNITY, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT EMPLOYMENT AND BUSINESS...

  5. Device-independent two-party cryptography secure against sequential attacks

    NASA Astrophysics Data System (ADS)

    Kaniewski, Jędrzej; Wehner, Stephanie

    2016-05-01

    The goal of two-party cryptography is to enable two parties, Alice and Bob, to solve common tasks without the need for mutual trust. Examples of such tasks are private access to a database, and secure identification. Quantum communication enables security for all of these problems in the noisy-storage model by sending more signals than the adversary can store in a certain time frame. Here, we initiate the study of device-independent (DI) protocols for two-party cryptography in the noisy-storage model. Specifically, we present a relatively easy to implement protocol for a cryptographic building block known as weak string erasure and prove its security even if the devices used in the protocol are prepared by the dishonest party. DI two-party cryptography is made challenging by the fact that Alice and Bob do not trust each other, which requires new techniques to establish security. We fully analyse the case of memoryless devices (for which sequential attacks are optimal) and the case of sequential attacks for arbitrary devices. The key ingredient of the proof, which might be of independent interest, is an explicit (and tight) relation between the violation of the Clauser-Horne-Shimony-Holt inequality observed by Alice and Bob and uncertainty generated by Alice against Bob who is forced to measure his system before finding out Alice’s setting (guessing with postmeasurement information). In particular, we show that security is possible for arbitrarily small violation.

  6. What's so important about conducting research involving third parties?

    PubMed

    Murrelle, L; McCarthy, C R

    2001-01-01

    Controversy has arisen over the long-standing practice of collecting family health and behavioral history information in the course of conducting biomedical research. Identifiable individuals (third parties) on whom investigators collect private data through primary research subjects (probands) also are considered research subjects. At issue is whether informed consent is required from third parties prior to obtaining information about them from probands. A recent federal regulatory ruling dictates that investigators must either obtain informed consent from all third parties or their research must qualify for a waiver of consent. Because of the ruling, a traditional family medical history questionnaire, typical of those routinely used in genetic epidemiologic studies of familial risk, failed to meet the criteria for the waiver. The implications of this ruling are far-reaching. They could influence the quality of research in the United States on the causes of most human diseases. To enable continuing medical and bioethical education on the topic, in March 2001, Virginia Commonwealth University hosted a 2-day open conference, "Third Party Rights and Risks: A Forum on Informed Consent from Persons Affected by the Study of Human Subjects." International leaders from the fields of biomedical ethics and law convened with federal regulatory officials, Institutional Review Board members, academic and industry scientists, and patient-family rights advocates to discuss and debate this critical topic. Conference presenters submitted papers to clarify the issues, promote continued debate, and assist in the formulation of policy recommendations regarding third-party rights and risks.

  7. 48 CFR 213.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Imprest funds and third party drafts. 213.305 Section 213.305 Federal Acquisition Regulations System DEFENSE ACQUISITION... PROCEDURES Simplified Acquisition Methods 213.305 Imprest funds and third party drafts. ...

  8. 48 CFR 213.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Imprest funds and third party drafts. 213.305 Section 213.305 Federal Acquisition Regulations System DEFENSE ACQUISITION... PROCEDURES Simplified Acquisition Methods 213.305 Imprest funds and third party drafts. ...

  9. 48 CFR 213.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Imprest funds and third party drafts. 213.305 Section 213.305 Federal Acquisition Regulations System DEFENSE ACQUISITION... PROCEDURES Simplified Acquisition Methods 213.305 Imprest funds and third party drafts. ...

  10. 48 CFR 213.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Imprest funds and third party drafts. 213.305 Section 213.305 Federal Acquisition Regulations System DEFENSE ACQUISITION... PROCEDURES Simplified Acquisition Methods 213.305 Imprest funds and third party drafts. ...

  11. 48 CFR 213.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Imprest funds and third party drafts. 213.305 Section 213.305 Federal Acquisition Regulations System DEFENSE ACQUISITION... PROCEDURES Simplified Acquisition Methods 213.305 Imprest funds and third party drafts. ...

  12. House Parties: An Innovative Model for Outreach and Community-Based Health Education.

    PubMed

    Anderson-Reeves, Timika; Goodman, Jacqueline; Bragg, Brian; Leruth, Chelsey

    2017-12-01

    Purpose To connect low resource communities to innovative services that address gaps in health access and knowledge. Description We describe the house party model, as a community-based workshop approach to health education developed by the Westside Healthy Start program (WHS) in Chicago, Illinois. Key elements of the WHS house party model include use of community health workers as facilitators, collaboration with participants and community-based organizations, referrals to health care and social services, and engagement strategies such as interactive activities, personal stories, and discussion. Assessment In 2014 and 2015, WHS completed 23 house parties with 271 participants, delivering education on relevant maternal and child health (MCH) topics. Participants demonstrated improvements in knowledge of several health-related areas. About half of participants were able to identify causes or signs of preterm labor prior to the house party, compared to over 80% after. In addition, 94% of participants rated the house party workshops "excellent" or "good". Conclusion House parties are a promising strategy for increasing knowledge about MCH topics and linking hard-to-reach populations to resources in the community.

  13. 17 CFR 200.69 - Conduct toward parties and their counsel.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Conduct toward parties and their counsel. 200.69 Section 200.69 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... toward parties and their counsel. Members should be temperate, attentive, patient and impartial when...

  14. 49 CFR 236.1017 - Independent third party Verification and Validation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Independent third party Verification and Validation. 236.1017 Section 236.1017 Transportation Other Regulations Relating to Transportation (Continued... Validation. (a) The PTCSP must be supported by an independent third-party assessment when the Associate...

  15. 49 CFR 236.1017 - Independent third party Verification and Validation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Independent third party Verification and Validation. 236.1017 Section 236.1017 Transportation Other Regulations Relating to Transportation (Continued... Validation. (a) The PTCSP must be supported by an independent third-party assessment when the Associate...

  16. 49 CFR 236.1017 - Independent third party Verification and Validation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Independent third party Verification and Validation. 236.1017 Section 236.1017 Transportation Other Regulations Relating to Transportation (Continued... Validation. (a) The PTCSP must be supported by an independent third-party assessment when the Associate...

  17. 49 CFR 236.1017 - Independent third party Verification and Validation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Independent third party Verification and Validation. 236.1017 Section 236.1017 Transportation Other Regulations Relating to Transportation (Continued... Validation. (a) The PTCSP must be supported by an independent third-party assessment when the Associate...

  18. 20 CFR 437.35 - Subawards to debarred and suspended parties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Subawards to debarred and suspended parties. 437.35 Section 437.35 Employees' Benefits SOCIAL SECURITY ADMINISTRATION UNIFORM ADMINISTRATIVE... Changes, Property, and Subawards § 437.35 Subawards to debarred and suspended parties. Grantees and...

  19. 20 CFR 437.35 - Subawards to debarred and suspended parties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Subawards to debarred and suspended parties. 437.35 Section 437.35 Employees' Benefits SOCIAL SECURITY ADMINISTRATION UNIFORM ADMINISTRATIVE... Changes, Property, and Subawards § 437.35 Subawards to debarred and suspended parties. Grantees and...

  20. Survey questions about party competence: Insights from cognitive interviews☆

    PubMed Central

    Wagner, Markus; Zeglovits, Eva

    2014-01-01

    Voter assessments of party competence have become a key explanation of electoral decision-making. However, there are at least three important aspects to understanding responses to questions on issue-specific party competence: comprehension difficulties; a lack of well-formed attitudes and relevant information; and the use of response heuristics. We used 20 cognitive interviews carried out in Austria in 2011 to test competence questions. The interviews show us how respondents explain their responses. We find evidence that many people (1) may hold only weak opinions and have little information on issue-specific party competence and (2) may make use of distinct but related concepts, particularly salience and position, when answering questions about competence. We provide recommendations for researchers and survey designers based on our findings. PMID:25844005

  1. On the security of a simple three-party key exchange protocol without server's public keys.

    PubMed

    Nam, Junghyun; Choo, Kim-Kwang Raymond; Park, Minkyu; Paik, Juryon; Won, Dongho

    2014-01-01

    Authenticated key exchange protocols are of fundamental importance in securing communications and are now extensively deployed for use in various real-world network applications. In this work, we reveal major previously unpublished security vulnerabilities in the password-based authenticated three-party key exchange protocol according to Lee and Hwang (2010): (1) the Lee-Hwang protocol is susceptible to a man-in-the-middle attack and thus fails to achieve implicit key authentication; (2) the protocol cannot protect clients' passwords against an offline dictionary attack; and (3) the indistinguishability-based security of the protocol can be easily broken even in the presence of a passive adversary. We also propose an improved password-based authenticated three-party key exchange protocol that addresses the security vulnerabilities identified in the Lee-Hwang protocol.

  2. On the Security of a Simple Three-Party Key Exchange Protocol without Server's Public Keys

    PubMed Central

    Nam, Junghyun; Choo, Kim-Kwang Raymond; Park, Minkyu; Paik, Juryon; Won, Dongho

    2014-01-01

    Authenticated key exchange protocols are of fundamental importance in securing communications and are now extensively deployed for use in various real-world network applications. In this work, we reveal major previously unpublished security vulnerabilities in the password-based authenticated three-party key exchange protocol according to Lee and Hwang (2010): (1) the Lee-Hwang protocol is susceptible to a man-in-the-middle attack and thus fails to achieve implicit key authentication; (2) the protocol cannot protect clients' passwords against an offline dictionary attack; and (3) the indistinguishability-based security of the protocol can be easily broken even in the presence of a passive adversary. We also propose an improved password-based authenticated three-party key exchange protocol that addresses the security vulnerabilities identified in the Lee-Hwang protocol. PMID:25258723

  3. 7 CFR 3052.515 - Audit working papers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Audit working papers. 3052.515 Section 3052.515....515 Audit working papers. (a) Retention of working papers. The auditor shall retain working papers and... the parties contesting the audit finding for guidance prior to destruction of the working papers and...

  4. The evolving role of third parties in the hospital physician relationship.

    PubMed

    Burns, Lawton R; Nash, David B; Wholey, Douglas R

    2007-01-01

    Hospital-physician relationships (HPRs) are a key concern for both parties. Hospital interest has been driven historically by the desire for the physician's clinical business, the need to combat managed care, and now the threats posed by single specialty hospitals, medical device vendors, and consumerism. Physician interest has been driven by fears of managed care and desires for new sources of revenue. The dyadic relationships between hospitals and physicians are thus motivated and influenced by the role of third parties. This article analyzes the history of HPRs and the succession of third parties. The analysis illustrates that the role of third parties has shifted from a unifying one to one that divides hospitals and physicians. This shift presents both opportunities and problems.

  5. 48 CFR 2813.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Imprest funds and third party drafts. 2813.305 Section 2813.305 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE....305 Imprest funds and third party drafts. Regulations governing the operation and procedures of the...

  6. 48 CFR 2813.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Imprest funds and third party drafts. 2813.305 Section 2813.305 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE....305 Imprest funds and third party drafts. Regulations governing the operation and procedures of the...

  7. 48 CFR 2813.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Imprest funds and third party drafts. 2813.305 Section 2813.305 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE....305 Imprest funds and third party drafts. Regulations governing the operation and procedures of the...

  8. 48 CFR 2813.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Imprest funds and third party drafts. 2813.305 Section 2813.305 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE....305 Imprest funds and third party drafts. Regulations governing the operation and procedures of the...

  9. 48 CFR 2813.305 - Imprest funds and third party drafts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Imprest funds and third party drafts. 2813.305 Section 2813.305 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE....305 Imprest funds and third party drafts. Regulations governing the operation and procedures of the...

  10. Lessons Learned from the Arizona Galileoscope Star Party Program

    NASA Astrophysics Data System (ADS)

    Pompea, Stephen M.; Sparks, R. T.; Dugan, C.; Walker, C. E.

    2013-01-01

    The National Optical Astronomy Observatory has joined together multiple audiences in various communities to conduct outreach using Galileoscopes. The audience consists of 5th grade students and teachers, their families and friends, and anyone else who wants to attend a special star party led by students using Galileoscopes. However, across one community there are many subcultures that one should be responsive to in the program design. The program model, which has been independently evaluated, combines professional development and classroom visits by NOAO education practitioners with the goal of a community star party. We have conducted the program in several mid-sized Arizona cities after an initial prototype star party held near the state capitol building in Phoenix. In this program, with Galileoscopes purchased with funding from Science Foundation Arizona, we have now held Galileoscope star parties in Flagstaff, Safford, and Globe, with two programs in Yuma, Arizona. We will discuss planning efforts, professional development plans and lessons learned, and specific logistical issues that have arisen in the program. Although the professional development component for teachers is rather traditional, the overall lessons learned are applicable to many astronomy programs for non-traditional audiences.

  11. JACIE accreditation for blood and marrow transplantation: past, present and future directions of an international model for healthcare quality improvement

    PubMed Central

    Snowden, J A; McGrath, E; Duarte, R F; Saccardi, R; Orchard, K; Worel, N; Kuball, J; Chabannon, C; Mohty, M

    2017-01-01

    Blood and marrow transplantation (BMT) is a complex and evolving medical speciality that makes substantial demands on healthcare resources. To meet a professional responsibility to both patients and public health services, the European Society for Blood and Marrow Transplantation (EBMT) initiated and developed the Joint Accreditation Committee of the International Society for Cellular Therapy and EBMT—better known by the acronym, JACIE. Since its inception, JACIE has performed over 530 voluntary accreditation inspections (62% first time; 38% reaccreditation) in 25 countries, representing 40% of transplant centres in Europe. As well as widespread professional acceptance, JACIE has become incorporated into the regulatory framework for delivery of BMT and other haematopoietic cellular therapies in several countries. In recent years, JACIE has been validated using the EBMT registry as an effective means of quality improvement with a substantial positive impact on survival outcomes. Future directions include development of Europe-wide risk-adjusted outcome benchmarking through the EBMT registry and further extension beyond Europe, including goals to faciliate access for BMT programmes in in low- and middle-income economies (LMIEs) via a ‘first-step’ process. PMID:28346416

  12. Prefrontal gray matter morphology mediates the association between serum anticholinergicity and cognitive functioning in early course schizophrenia.

    PubMed

    Wojtalik, Jessica A; Eack, Shaun M; Pollock, Bruce G; Keshavan, Matcheri S

    2012-11-30

    Antipsychotic and other medications used in the treatment of schizophrenia place a burden on the cholinergic subsystems of the brain, which have been associated with increased cognitive impairment in the disorder. This study sought to examine the neurobiologic correlates of the association between serum anticholinergic activity (SAA) and cognitive impairments in early schizophrenia. Neurocognitive performance on measures of memory and executive function, structural magnetic resonance imaging (MRI) scans, and SAA assays were collected from 47 early course, stabilized outpatients with schizophrenia or schizoaffective disorder. Voxel-based morphometry analyses employing general linear models, adjusting for demographic and illness-related confounds, were used to investigate the associations between SAA, gray matter morphology, and neurocognitive impairment. SAA was related to working memory and executive function impairments. Higher SAA was significantly associated with lower gray matter density in broad regions of the frontal and medial-temporal lobes, including the dorsolateral prefrontal cortex (DLPFC), hippocampus, and striatum. Lower gray matter volume in the left DLPFC was found to significantly mediate the association between SAA and working memory impairment. Disease- and/or medication-related cholinergic dysfunction may be associated with brain volume abnormalities in early course schizophrenia, which may account for the association between SAA and cognitive dysfunction in the disorder. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  13. Tonsillectomy and Adenoidectomy in Children with Sleep-Related Breathing Disorders: Consensus Statement of a UK Multidisciplinary Working Party

    PubMed Central

    Robb, PJ; Bew, S; Kubba, H; Murphy, N; Primhak, R; Rollin, A-M; Tremlett, M

    2009-01-01

    During 2008, ENT-UK received a number of professional enquiries from colleagues about the management of children with upper airway obstruction and uncomplicated obstructive sleep apnoea (OSA). These children with sleep-related breathing disorders (SRBDs) are usually referred to paediatricians and ENT surgeons. In some district general hospitals, (DGHs) where paediatric intensive care (PICU) facilities to ventilate children were not available, paediatrician and anaesthetist colleagues were expressing concern about children with a clinical diagnosis of OSA having routine tonsillectomy, with or without adenoidectomy. As BAPO President, I was asked by the ENT-UK President, Professor Richard Ramsden, to investigate the issues and rapidly develop a working consensus statement to support safe but local treatment of these children. The Royal Colleges of Anaesthetists and Paediatrics and Child Health and the Association of Paediatric Anaesthetists nominated expert members from both secondary and tertiary care to contribute and develop a consensus statement based on the limited evidence base available. Our terms of reference were to produce a statement that was brief, with a limited number of references, to inform decision-making at the present time. With patient safety as the first priority, the working party wished to support practice that facilitated referral to a tertiary centre of those children who could be expected, on clinical assessment alone, potentially to require PICU facilities. In contrast, the majority of children who could be safely managed in a secondary care setting should be managed closer to home in a DGH. BAPO, ENT-UK, APA, RCS-CSF and RCoA have endorsed the consensus statement; the RCPCH has no mechanism for endorsing consensus statements, but the RCPCH Clinical Effectiveness Committee reviewed the statement, concluding it was a ‘concise, accurate and helpful document’. The consensus statement is an interim working tool, based on level-five evidence

  14. Computational Substrates of Social Norm Enforcement by Unaffected Third Parties

    PubMed Central

    Zhong, Songfa; Chark, Robin; Hsu, Ming; Chew, Soo Hong

    2016-01-01

    Enforcement of social norms by impartial bystanders in the human species reveals a possibly unique capacity to sense and to enforce norms from a third party perspective. Such behavior, however, cannot be accounted by current computational models based on an egocentric notion of norms. Here, using a combination of model-based fMRI and third party punishment games, we show that brain regions previously implicated in egocentric norm enforcement critically extend to the important case of norm enforcement by unaffected third parties. Specifically, we found that responses in the ACC and insula cortex were positively associated with detection of distributional inequity, while those in the anterior DLPFC were associated with assessment of intentionality to the violator. Moreover, during sanction decisions, the subjective value of sanctions modulated activity in both vmPFC and rTPJ. These results shed light on the neurocomputational underpinnings of third party punishment and evolutionary origin of human norm enforcement. PMID:26825438

  15. Computational substrates of social norm enforcement by unaffected third parties.

    PubMed

    Zhong, Songfa; Chark, Robin; Hsu, Ming; Chew, Soo Hong

    2016-04-01

    Enforcement of social norms by impartial bystanders in the human species reveals a possibly unique capacity to sense and to enforce norms from a third party perspective. Such behavior, however, cannot be accounted by current computational models based on an egocentric notion of norms. Here, using a combination of model-based fMRI and third party punishment games, we show that brain regions previously implicated in egocentric norm enforcement critically extend to the important case of norm enforcement by unaffected third parties. Specifically, we found that responses in the ACC and insula cortex were positively associated with detection of distributional inequity, while those in the anterior DLPFC were associated with assessment of intentionality to the violator. Moreover, during sanction decisions, the subjective value of sanctions modulated activity in both vmPFC and rTPJ. These results shed light on the neurocomputational underpinnings of third party punishment and evolutionary origin of human norm enforcement. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Education and Working Life.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France).

    The development of national policies for education and employment is the major concern of this report of a joint working party of officials from member countries of the Organization for Economic Cooperation and Development (OECD). Focus is on the objectives of public policies for education and working life and on how they can be attained in…

  17. 29 CFR 99.515 - Audit working papers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Audit working papers. 99.515 Section 99.515 Labor Office of....515 Audit working papers. (a) Retention of working papers. The auditor shall retain working papers and... the parties contesting the audit finding for guidance prior to destruction of the working papers and...

  18. 18 CFR 35.8 - Protests and interventions by interested parties.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... interventions by interested parties. 35.8 Section 35.8 Conservation of Power and Water Resources FEDERAL ENERGY... AND TARIFFS Application § 35.8 Protests and interventions by interested parties. Unless the notice issued by the Commission provides otherwise, any protest or intervention to a rate filing made pursuant...

  19. 18 CFR 35.8 - Protests and interventions by interested parties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... interventions by interested parties. 35.8 Section 35.8 Conservation of Power and Water Resources FEDERAL ENERGY... AND TARIFFS Application § 35.8 Protests and interventions by interested parties. Unless the notice issued by the Commission provides otherwise, any protest or intervention to a rate filing made pursuant...

  20. 18 CFR 35.8 - Protests and interventions by interested parties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... interventions by interested parties. 35.8 Section 35.8 Conservation of Power and Water Resources FEDERAL ENERGY... AND TARIFFS Application § 35.8 Protests and interventions by interested parties. Unless the notice issued by the Commission provides otherwise, any protest or intervention to a rate filing made pursuant...

  1. 18 CFR 35.8 - Protests and interventions by interested parties.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... interventions by interested parties. 35.8 Section 35.8 Conservation of Power and Water Resources FEDERAL ENERGY... AND TARIFFS Application § 35.8 Protests and interventions by interested parties. Unless the notice issued by the Commission provides otherwise, any protest or intervention to a rate filing made pursuant...

  2. 18 CFR 35.8 - Protests and interventions by interested parties.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... interventions by interested parties. 35.8 Section 35.8 Conservation of Power and Water Resources FEDERAL ENERGY... AND TARIFFS Application § 35.8 Protests and interventions by interested parties. Unless the notice issued by the Commission provides otherwise, any protest or intervention to a rate filing made pursuant...

  3. 22 CFR 1101.8 - Disclosure of records to third-parties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Disclosure of records to third-parties. 1101.8 Section 1101.8 Foreign Relations INTERNATIONAL BOUNDARY AND WATER COMMISSION, UNITED STATES AND MEXICO, UNITED STATES SECTION PRIVACY ACT OF 1974 § 1101.8 Disclosure of records to third-parties. (a) The...

  4. 22 CFR 1101.8 - Disclosure of records to third-parties.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Disclosure of records to third-parties. 1101.8 Section 1101.8 Foreign Relations INTERNATIONAL BOUNDARY AND WATER COMMISSION, UNITED STATES AND MEXICO, UNITED STATES SECTION PRIVACY ACT OF 1974 § 1101.8 Disclosure of records to third-parties. (a) The...

  5. 43 CFR 30.222 - What happens if a party fails to comply with discovery?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false What happens if a party fails to comply... Conference § 30.222 What happens if a party fails to comply with discovery? (a) If a party fails to respond..., unless the judge finds good cause for the failure to respond. (b) If a party fails without good cause to...

  6. 43 CFR 30.222 - What happens if a party fails to comply with discovery?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false What happens if a party fails to comply... Conference § 30.222 What happens if a party fails to comply with discovery? (a) If a party fails to respond..., unless the judge finds good cause for the failure to respond. (b) If a party fails without good cause to...

  7. 43 CFR 30.222 - What happens if a party fails to comply with discovery?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true What happens if a party fails to comply... Conference § 30.222 What happens if a party fails to comply with discovery? (a) If a party fails to respond..., unless the judge finds good cause for the failure to respond. (b) If a party fails without good cause to...

  8. 43 CFR 30.222 - What happens if a party fails to comply with discovery?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false What happens if a party fails to comply... Conference § 30.222 What happens if a party fails to comply with discovery? (a) If a party fails to respond..., unless the judge finds good cause for the failure to respond. (b) If a party fails without good cause to...

  9. 43 CFR 30.222 - What happens if a party fails to comply with discovery?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false What happens if a party fails to comply... Conference § 30.222 What happens if a party fails to comply with discovery? (a) If a party fails to respond..., unless the judge finds good cause for the failure to respond. (b) If a party fails without good cause to...

  10. Reduced intensity conditioning allogeneic hematopoietic cell transplantation for adult acute myeloid leukemia in complete remission - a review from the Acute Leukemia Working Party of the EBMT

    PubMed Central

    Sengsayadeth, Salyka; Savani, Bipin N.; Blaise, Didier; Malard, Florent; Nagler, Arnon; Mohty, Mohamad

    2015-01-01

    Acute myeloid leukemia is the most common indication for an allogeneic hematopoietic cell transplant. The introduction of reduced intensity conditioning has expanded the recipient pool for transplantation, which has importantly made transplant an option for the more commonly affected older age groups. Reduced intensity conditioning allogeneic transplantation is currently the standard of care for patients with intermediate or high-risk acute myeloid leukemia and is now most often employed in older patients and those with medical comorbidities. Despite being curative for a significant proportion of patients, post-transplant relapse remains a challenge in the reduced intensity conditioning setting. Herein we discuss the studies that demonstrate the feasibility of reduced intensity conditioning allogeneic transplants, compare the outcomes of reduced intensity conditioning versus chemotherapy and conventional myeloablative conditioning regimens, describe the optimal donor and stem cell source, and consider the impact of post-remission consolidation, comorbidities, center experience, and more intensive (reduced toxicity conditioning) regimens on outcomes. Additionally, we discuss the need for further prospective studies to optimize transplant outcomes. PMID:26130513

  11. South Atlantic Anomaly Entry and Exit as Measured by the X-Ray Timing Explorer

    NASA Technical Reports Server (NTRS)

    Smith, Evan; Stark, Michael; Giles, Barry; Antunes, Sandy; Gawne, Bill

    1996-01-01

    The Rossi X-ray Timing Explorer (RXTE) carries instruments that must switch off high voltages (HV) when passing through the South Atlantic Anomaly (SAA). The High Energy X-ray Timing Experiment (HEXTE) contains a particle monitor that detects the increased particle flux associated with the SAA and autonomously reduces its voltage. The Proportional Counter Array (PCA) relies on uplinked predictions of SAA entry/exit times based on ephemeris data provided by the Flight Dynamics Facility. A third instrument, the All-Sky Monitor (ASM) also uses a predicted SAA model to reduce voltage when passing through the SAA. Data collected from the HEXTE particle monitor, as well as other instrument readings near the times of SAA entry/exit offer the potential for refining models of the boundaries of the SAA. The SAA has an increased particle flux which causes high rates of detection in the RXTE instruments designed to observe x-rays. The high counting rates could degrade the PCA if HV is not reduced during SAA passages. On the other hand, PCA downtime can be minimized and the science return can be optimized by having the best possible model of the SAA boundary. Thus, the PCA team planned an extensive effort during in-orbit checkout to utilize both the HEXTE particle monitor data and instrument counting rates to refine the model of the SAA boundary. The times of SAA entry and exit are compared with the definitive epemeris to determine the precise location (latitude and longitude) of the SAA boundary. Over time, the SAA and its perimeter were mapped. The RXTE Science Operations Center is continuously working to feed back the results of this effort into the science scheduling process, improving the SAA model as it affects the RXTE instruments, thus obtaining more accurate estimates of the SAA entry/exit times.

  12. Feature Project--A Bookmaking Party.

    ERIC Educational Resources Information Center

    Drury, Lori; And Others

    1984-01-01

    The teaching activities presented in this article focus on a bookmaking party, which gives children a format in which they can publish and share their activities in a formal way, provides them with books for recording their writing, and involves students, parents, and the community with children's writing. The paper describes the steps for…

  13. 34 CFR 682.416 - Requirements for third-party servicers and lenders contracting with third-party servicers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM Administration of the Federal Family Education Loan Programs by a Guaranty... 34 Education 3 2010-07-01 2010-07-01 false Requirements for third-party servicers and lenders...

  14. 10 CFR 1705.09 - Disclosure of records to third parties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Disclosure of records to third parties. 1705.09 Section 1705.09 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.09 Disclosure of records to third parties. Records subject to the Privacy Act that are requested by any person other than the...

  15. 10 CFR 1705.09 - Disclosure of records to third parties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Disclosure of records to third parties. 1705.09 Section 1705.09 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.09 Disclosure of records to third parties. Records subject to the Privacy Act that are requested by any person other than the...

  16. 10 CFR 1705.09 - Disclosure of records to third parties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Disclosure of records to third parties. 1705.09 Section 1705.09 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.09 Disclosure of records to third parties. Records subject to the Privacy Act that are requested by any person other than the...

  17. 15 CFR 758.3 - Responsibilities of parties to the transaction.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... principal party in interest the exporter for EAR purposes. One writing may cover multiple transactions between the same principals. See § 748.4(a)(3) of the EAR. Note to paragraph (b): For statistical purposes.... principal party in interest. For purposes of licensing responsibility under the EAR, the U.S. agent of the...

  18. 15 CFR 758.3 - Responsibilities of parties to the transaction.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... principal party in interest the exporter for EAR purposes. One writing may cover multiple transactions between the same principals. See § 748.4(a)(3) of the EAR. Note to paragraph (b): For statistical purposes.... principal party in interest. For purposes of licensing responsibility under the EAR, the U.S. agent of the...

  19. 15 CFR 758.3 - Responsibilities of parties to the transaction.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... principal party in interest the exporter for EAR purposes. One writing may cover multiple transactions between the same principals. See § 748.4(a)(3) of the EAR. Note to paragraph (b): For statistical purposes.... principal party in interest. For purposes of licensing responsibility under the EAR, the U.S. agent of the...

  20. 15 CFR 758.3 - Responsibilities of parties to the transaction.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... principal party in interest the exporter for EAR purposes. One writing may cover multiple transactions between the same principals. See § 748.4(a)(3) of the EAR. Note to paragraph (b): For statistical purposes.... principal party in interest. For purposes of licensing responsibility under the EAR, the U.S. agent of the...

  1. 15 CFR 758.3 - Responsibilities of parties to the transaction.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... principal party in interest the exporter for EAR purposes. One writing may cover multiple transactions between the same principals. See § 748.4(a)(3) of the EAR. Note to paragraph (b): For statistical purposes.... principal party in interest. For purposes of licensing responsibility under the EAR, the U.S. agent of the...

  2. 10 CFR 1705.09 - Disclosure of records to third parties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Disclosure of records to third parties. 1705.09 Section 1705.09 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.09 Disclosure of records to third parties. Records subject to the Privacy Act that are requested by any person other than the...

  3. 10 CFR 1705.09 - Disclosure of records to third parties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Disclosure of records to third parties. 1705.09 Section 1705.09 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.09 Disclosure of records to third parties. Records subject to the Privacy Act that are requested by any person other than the...

  4. 78 FR 77354 - Procedural Rules To Permit Parties To File and Serve Documents Electronically

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... by handwriting his or her signature. For documents filed by electronic transmission, a party may sign... transmission. A party or representative of the party shall sign a document by handwriting his signature. (2...

  5. Ecologies of ideologies: Explaining party entry and exit in West-European parliaments, 1945-2013.

    PubMed

    van de Wardt, Marc; Berkhout, Joost; Vermeulen, Floris

    2017-06-01

    This study introduces a population-ecological approach to the entry and exit of political parties. A primary proposition of population ecology is that organizational entry and exit depends on the number of organizations already present: that is, density. We propose that political parties mainly experience competition from parties in the same ideological niche (left, centre, right). Pooled time-series analyses of 410 parties, 263 elections and 18 West-European countries largely support our expectations. We find that political parties are more likely to exit when density within their niche increases. Also there is competition between adjacent ideological niches, i.e. between centrist and right-wing niches. In contrast to our expectations, neither density nor institutional rules impact party entry. This raises important questions about the rationale of prospective entrants.

  6. An international nomenclature for forest work study

    Treesearch

    Rolf Bjorheden; Michael A. Thompson

    2000-01-01

    Knowledge gained in the study of forest work is used to improve operational efficiency through better planning and control of future work. Internationally recognized standard methods for recording, evaluating and reporting performance in forest work will greatly enhance the usefulness of this information to managers and planners. A subcommittee of IUFRO Working Party...

  7. An international nomenclature for forest work study

    Treesearch

    Rolf Björheden; Michael A.  Thompson

    2000-01-01

    Knowledge gained in the study of forest work is used to improve operational efficiency through better planning and control of future work. Internationally recognized standard methods for recording, evaluating and reporting performance in forest work will greatly enhance the usefulness of this information to managers and planners. A subcommittee of IUFRO Working Party $...

  8. Plasma drug concentrations and physiological measures in 'dance party' participants.

    PubMed

    Irvine, Rodney J; Keane, Michael; Felgate, Peter; McCann, Una D; Callaghan, Paul D; White, Jason M

    2006-02-01

    The increasing use of (+/-) 3,4-methylenedioxymethamphetamine (MDMA) in the setting of large dance parties ('raves') and clubs has been the source of some concern, because of potential acute adverse events, and because animal studies suggest that MDMA has the potential to damage brain serotonin (5-HT) neurons. However, it is not yet known whether MDMA, as used in the setting of dance parties, leads to plasma levels of MDMA that are associated with toxicity to 5-HT neurons in animals. The present study sought to address this question. Plasma MDMA concentrations, vital signs, and a variety of blood and urine measures were obtained prior to, and hours after, individuals attended a dance party. After the dance party, subjects were without clinical complaints, had measurable amounts of residual MDMA in plasma, and nearly half of the subjects also tested positive for methamphetamine, another amphetamine analog that has been shown to have 5-HT neurotoxic potential in animals. Plasma concentrations of MDMA did not correlate with self-reported use of 'ecstasy' and, in some subjects, overlapped with those that have been associated with 5-HT neurotoxicity in non-human primates. Additional subjects were likely to have had similar concentrations while at the dance party, when one considers the reported time of drug ingestion and the plasma half-life of MDMA in humans. Hematological and biochemical analyses were generally unremarkable. Moderate increases in blood pressure, heart rate and body temperature were observed in the subjects with the highest MDMA plasma concentrations. These findings are consistent with epidemiological findings that most people who use MDMA at dance parties do not develop serious clinical complications, and suggest that some of these individuals may be at risk for developing MDMA-induced toxicity to brain serotonin neurons.

  9. Web party effect: a cocktail party effect in the web environment.

    PubMed

    Rigutti, Sara; Fantoni, Carlo; Gerbino, Walter

    2015-01-01

    In goal-directed web navigation, labels compete for selection: this process often involves knowledge integration and requires selective attention to manage the dizziness of web layouts. Here we ask whether the competition for selection depends on all web navigation options or only on those options that are more likely to be useful for information seeking, and provide evidence in favor of the latter alternative. Participants in our experiment navigated a representative set of real websites of variable complexity, in order to reach an information goal located two clicks away from the starting home page. The time needed to reach the goal was accounted for by a novel measure of home page complexity based on a part of (not all) web options: the number of links embedded within web navigation elements weighted by the number and type of embedding elements. Our measure fully mediated the effect of several standard complexity metrics (the overall number of links, words, images, graphical regions, the JPEG file size of home page screenshots) on information seeking time and usability ratings. Furthermore, it predicted the cognitive demand of web navigation, as revealed by the duration judgment ratio (i.e., the ratio of subjective to objective duration of information search). Results demonstrate that focusing on relevant links while ignoring other web objects optimizes the deployment of attentional resources necessary to navigation. This is in line with a web party effect (i.e., a cocktail party effect in the web environment): users tune into web elements that are relevant for the achievement of their navigation goals and tune out all others.

  10. Utilization of third-party in vitro fertilization in the United States.

    PubMed

    Kushnir, Vitaly A; Darmon, Sarah K; Shapiro, Alice J; Albertini, David F; Barad, David H; Gleicher, Norbert

    2017-03-01

    The use of in vitro fertilization that includes third-party in vitro fertilization is increasing. However, the relative contribution of third-party in vitro fertilization that includes the use of donor oocytes, sperm, or embryo and a gestational carrier to the birth cohort after in vitro fertilization is unknown. The purpose of this study was to examine the contribution of third-party in vitro fertilization to the in vitro fertilization birth cohort over the past decade. This retrospective analysis investigated 1,349,874 in vitro fertilization cycles that resulted in 421,525 live births and 549,367 liveborn infants in the United States from 2004-2013. Cycles were self-reported by fertility centers to a national registry: Society for Assisted Reproductive Technologies Clinic Outcome Reporting System. Third-party in vitro fertilization accounted for 217,030 (16.1%) of all in vitro fertilization cycles, 86,063 (20.4%) of all live births, and 115,024 (20.9%) of all liveborn infants. Overall, 39.7% of third-party in vitro fertilization cycles resulted in a live birth, compared with 29.6% of autologous in vitro fertilization cycles. Use of third-party in vitro fertilization increased with maternal age and accounted for 42.2% of all in vitro fertilization cycles and 75.3% of all liveborn infants among women >40 years old. Oocyte donation was the most common third-party in vitro fertilization technique, followed by sperm donation. Over the study period, annual cycle volume and live birth rates gradually increased for both autologous in vitro fertilization and third-party in vitro fertilization (P<.0001 for all). Live birth rates were the highest when multiple third-party in vitro fertilization modalities were used, followed by oocyte donation. Third-party in vitro fertilization use and efficacy have increased over the past decade, now comprising >20% of the total in vitro fertilization birth cohort. In women who are >40 years old, third-party in

  11. 19 CFR 12.104b - State Parties to the Convention.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., acceptance, accession or succession, the date of such deposit and the date of entry into force for each State Party: State party Date of deposit Date of entry into force Algeria June 24, 1974 (R) Sept. 24, 1974... entered into force on July 28, 1988. 2. Bosnia-Herzegovina, Croatia and the Republic of Slovenia each...

  12. 19 CFR 12.104b - State Parties to the Convention.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., acceptance, accession or succession, the date of such deposit and the date of entry into force for each State Party: State party Date of deposit Date of entry into force Algeria June 24, 1974 (R) Sept. 24, 1974... entered into force on July 28, 1988. 2. Bosnia-Herzegovina, Croatia and the Republic of Slovenia each...

  13. 17 CFR 201.210 - Parties, limited participants and amici curiae.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... protection of investors or consumers, may be admitted as a party upon the filing of a written motion setting... proceeding may be in the public interest or for the protection of investors, may be admitted as a party upon... affecting the person's interests: (1) Procedure. Motions for leave to participate shall be in writing, shall...

  14. 10 CFR 1304.110 - Disclosure of records to third parties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Disclosure of records to third parties. 1304.110 Section 1304.110 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.110 Disclosure of records to third parties. (a) The Board will not disclose any record that is contained in a system of...

  15. 10 CFR 1304.110 - Disclosure of records to third parties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Disclosure of records to third parties. 1304.110 Section 1304.110 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.110 Disclosure of records to third parties. (a) The Board will not disclose any record that is contained in a system of...

  16. 10 CFR 1304.110 - Disclosure of records to third parties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Disclosure of records to third parties. 1304.110 Section 1304.110 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.110 Disclosure of records to third parties. (a) The Board will not disclose any record that is contained in a system of...

  17. 5 CFR 470.203 - Eligible parties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT RESEARCH PROGRAMS AND DEMONSTRATIONS PROJECTS Regulatory Requirements Pertaining to Research Programs § 470.203 Eligible parties. Research may be conducted by the Office of Personnel Management, or under contract or...

  18. Aerodynamics of a Party Balloon

    ERIC Educational Resources Information Center

    Cross, Rod

    2007-01-01

    It is well-known that a party balloon can be made to fly erratically across a room, but it can also be used for quantitative measurements of other aspects of aerodynamics. Since a balloon is light and has a large surface area, even relatively weak aerodynamic forces can be readily demonstrated or measured in the classroom. Accurate measurements…

  19. 78 FR 44090 - Formaldehyde; Third-Party Certification Framework for the Formaldehyde Standards for Composite...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... Formaldehyde; Third-Party Certification Framework for the Formaldehyde Standards for Composite Wood Products..., concerning a third-party certification framework for the formaldehyde standards for composite wood products... Environmental protection, Composite wood products, Formaldehyde, Reporting and recordkeeping, Third-party...

  20. Third-party punishment increases cooperation in children through (misaligned) expectations and conditional cooperation

    PubMed Central

    Lergetporer, Philipp; Angerer, Silvia; Glätzle-Rützler, Daniela; Sutter, Matthias

    2014-01-01

    The human ability to establish cooperation, even in large groups of genetically unrelated strangers, depends upon the enforcement of cooperation norms. Third-party punishment is one important factor to explain high levels of cooperation among humans, although it is still somewhat disputed whether other animal species also use this mechanism for promoting cooperation. We study the effectiveness of third-party punishment to increase children’s cooperative behavior in a large-scale cooperation game. Based on an experiment with 1,120 children, aged 7 to 11 y, we find that the threat of third-party punishment more than doubles cooperation rates, despite the fact that children are rarely willing to execute costly punishment. We can show that the higher cooperation levels with third-party punishment are driven by two components. First, cooperation is a rational (expected payoff-maximizing) response to incorrect beliefs about the punishment behavior of third parties. Second, cooperation is a conditionally cooperative reaction to correct beliefs that third party punishment will increase a partner’s level of cooperation. PMID:24778231

  1. Third-party punishment increases cooperation in children through (misaligned) expectations and conditional cooperation.

    PubMed

    Lergetporer, Philipp; Angerer, Silvia; Glätzle-Rützler, Daniela; Sutter, Matthias

    2014-05-13

    The human ability to establish cooperation, even in large groups of genetically unrelated strangers, depends upon the enforcement of cooperation norms. Third-party punishment is one important factor to explain high levels of cooperation among humans, although it is still somewhat disputed whether other animal species also use this mechanism for promoting cooperation. We study the effectiveness of third-party punishment to increase children's cooperative behavior in a large-scale cooperation game. Based on an experiment with 1,120 children, aged 7 to 11 y, we find that the threat of third-party punishment more than doubles cooperation rates, despite the fact that children are rarely willing to execute costly punishment. We can show that the higher cooperation levels with third-party punishment are driven by two components. First, cooperation is a rational (expected payoff-maximizing) response to incorrect beliefs about the punishment behavior of third parties. Second, cooperation is a conditionally cooperative reaction to correct beliefs that third party punishment will increase a partner's level of cooperation.

  2. Looking Under the Hood of Third-Party Punishment Reveals Design for Personal Benefit.

    PubMed

    Krasnow, Max M; Delton, Andrew W; Cosmides, Leda; Tooby, John

    2016-03-01

    Third-party intervention, such as when a crowd stops a mugger, is common. Yet it seems irrational because it has real costs but may provide no personal benefits. In a laboratory analogue, the third-party-punishment game, third parties ("punishers") will often spend real money to anonymously punish bad behavior directed at other people. A common explanation is that third-party punishment exists to maintain a cooperative society. We tested a different explanation: Third-party punishment results from a deterrence psychology for defending personal interests. Because humans evolved in small-scale, face-to-face social worlds, the mind infers that mistreatment of a third party predicts later mistreatment of oneself. We showed that when punishers do not have information about how they personally will be treated, they infer that mistreatment of other people predicts mistreatment of themselves, and these inferences predict punishment. But when information about personal mistreatment is available, it drives punishment. This suggests that humans' punitive psychology evolved to defend personal interests. © The Author(s) 2016.

  3. 7 CFR 955.91 - Additional parties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Additional parties. 955.91 Section 955.91 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE VIDALIA ONIONS GROWN IN GEORGIA...

  4. 7 CFR 955.91 - Additional parties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Additional parties. 955.91 Section 955.91 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE VIDALIA ONIONS GROWN IN GEORGIA...

  5. 7 CFR 955.91 - Additional parties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Additional parties. 955.91 Section 955.91 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE VIDALIA ONIONS GROWN IN GEORGIA...

  6. 7 CFR 955.91 - Additional parties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Additional parties. 955.91 Section 955.91 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE VIDALIA ONIONS GROWN IN GEORGIA...

  7. 7 CFR 955.91 - Additional parties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Additional parties. 955.91 Section 955.91 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE VIDALIA ONIONS GROWN IN GEORGIA...

  8. 47 CFR 76.93 - Parties entitled to network non-duplication protection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Parties entitled to network non-duplication... RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Network Non-duplication Protection, Syndicated Exclusivity and Sports Blackout § 76.93 Parties entitled to network non-duplication protection...

  9. 47 CFR 76.93 - Parties entitled to network non-duplication protection.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Parties entitled to network non-duplication... RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Network Non-duplication Protection, Syndicated Exclusivity and Sports Blackout § 76.93 Parties entitled to network non-duplication protection...

  10. 48 CFR 3027.306 - Licensing background patent rights to third parties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... patent rights to third parties. 3027.306 Section 3027.306 Federal Acquisition Regulations System... PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 3027.306 Licensing background patent rights to third parties. (b) The CPO shall make the required determinations and notifications...

  11. The Soviet Union and the Socialist and Social Democratic Parties of Western Europe.

    DTIC Science & Technology

    1986-02-01

    British forces, Craxi stated, "Those missiles are not on the moon," Corriere della Sera, May 30, 1985. • 7 .- P.- N" It.- ’j -9.’-V 1.r". k7 17- -. W...Party (PIP) Progressive Labor Party of St. Lucia (PLP) People’s Electoral Movement (MEP), Venezuela Consultative Parties-in-Exile Bulgarian Social

  12. Two-Party secret key distribution via a modified quantum secret sharing protocol

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Grice, Warren P.; Evans, Philip G.; Lawrie, Benjamin

    We present and demonstrate a method of distributing secret information based on N-party single-qubit Quantum Secret Sharing (QSS) in a modied plug-and-play two-party Quantum Key Distribution (QKD) system with N 2 intermediate nodes and compare it to both standard QSS and QKD. Our setup is based on the Clavis2 QKD system built by ID Quantique but is generalizable to any implementation. We show that any two out of N parties can build a secret key based on partial information from each other and with collaboration from the remaining N 2 parties. This method signicantly reduces the number of resources (singlemore » photon detectors, lasers and dark ber connections) needed to implement QKD on the grid.« less

  13. Two-Party secret key distribution via a modified quantum secret sharing protocol

    DOE PAGES

    Grice, Warren P.; Evans, Philip G.; Lawrie, Benjamin; ...

    2015-01-01

    We present and demonstrate a method of distributing secret information based on N-party single-qubit Quantum Secret Sharing (QSS) in a modied plug-and-play two-party Quantum Key Distribution (QKD) system with N 2 intermediate nodes and compare it to both standard QSS and QKD. Our setup is based on the Clavis2 QKD system built by ID Quantique but is generalizable to any implementation. We show that any two out of N parties can build a secret key based on partial information from each other and with collaboration from the remaining N 2 parties. This method signicantly reduces the number of resources (singlemore » photon detectors, lasers and dark ber connections) needed to implement QKD on the grid.« less

  14. 28 CFR 513.35 - Accounting/nonaccounting of disclosures to third parties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Accounting/nonaccounting of disclosures... and Procedures § 513.35 Accounting/nonaccounting of disclosures to third parties. Accounting/nonaccounting of disclosures to third parties shall be made in accordance with Department of Justice regulations...

  15. 48 CFR 27.306 - Licensing background patent rights to third parties.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... patent rights to third parties. 27.306 Section 27.306 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 27.306 Licensing background patent rights to third parties. (a) A contract with a small...

  16. 48 CFR 27.306 - Licensing background patent rights to third parties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... patent rights to third parties. 27.306 Section 27.306 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 27.306 Licensing background patent rights to third parties. (a) A contract with a small...

  17. Quantum solution to a class of two-party private summation problems

    NASA Astrophysics Data System (ADS)

    Shi, Run-Hua; Zhang, Shun

    2017-09-01

    In this paper, we define a class of special two-party private summation (S2PPS) problems and present a common quantum solution to S2PPS problems. Compared to related classical solutions, our solution has advantages of higher security and lower communication complexity, and especially it can ensure the fairness of two parties without the help of a third party. Furthermore, we investigate the practical applications of our proposed S2PPS protocol in many privacy-preserving settings with big data sets, including private similarity decision, anonymous authentication, social networks, secure trade negotiation, secure data mining.

  18. SWAB/NVALT (Dutch Working Party on Antibiotic Policy and Dutch Association of Chest Physicians) guidelines on the management of community-acquired pneumonia in adults.

    PubMed

    Wiersinga, W J; Bonten, M J; Boersma, W G; Jonkers, R E; Aleva, R M; Kullberg, B J; Schouten, J A; Degener, J E; Janknegt, R; Verheij, T J; Sachs, A P E; Prins, J M

    2012-03-01

    The Dutch Working Party on Antibiotic Policy (SWAB) and the Dutch Association of Chest Physicians (NVALT) convened a joint committee to develop evidence-based guidelines on the diagnosis and treatment of community acquired pneumonia (CAP). The guidelines are intended for adult patients with CAP who present at the hospital and are treated as outpatients as well as for hospitalised patients up to 72 hours after admission. Areas covered include current patterns of epidemiology and antibiotic resistance of causative agents of CAP in the Netherlands, the possibility to predict the causative agent of CAP on the basis of clinical data at first presentation, risk factors associated with specific pathogens, the importance of the severity of disease upon presentation for choice of initial treatment, the role of rapid diagnostic tests in treatment decisions, the optimal initial empiric treatment and treatment when a specific pathogen has been identified, the timeframe in which the first dose of antibiotics should be given, optimal duration of antibiotic treatment and antibiotic switch from the intravenous to the oral route. Additional recommendations are made on the role of radiological investigations in the diagnostic work-up of patients with a clinical suspicion of CAP, on the potential benefit of adjunctive immunotherapy, and on the policy for patients with parapneumonic effusions.

  19. [Hematopoietic Reconstitution and Prognosis of HLA Matched and Haploidentical Hematopoietic Stem Cell Transplantation Using Modified FC/ATG Conditioning for Treatment of Severe Aplastic Anemia].

    PubMed

    Wang, Li; Wu, Ya-Mei; Cao, Yong-Bin; Li, Xiao-Hong; Xu, Li-Xin; Wang, Hai-Tao; Gao, Ya-Hui; Wu, Xiao-Xiong

    2016-12-01

    To analyse the feasibility and compare differences between hematopoietic reconstitution and prognosis of patients with severe aplastic anemia(SAA) after matched sibling donor (MSD) or haploidentical family donor (HFD) hematopoietic stem cell transplantation (HSCT) using the modified FC/ATG conditioning. The clinical data of 56 patients with SAA who received HSCT in First Affiliated Hospital of Chinese PLA General Hospital from January 2011 to June 2016 were analyzed retrospectively. The hematopoietic reconstitution, graft verus host disease (GVHD), transplantation related toxicity (TRT) and prognosis after transplantation were compared. Furthermore, the modifed conditioning FC/ATG included low-dose cyclophosphamide (total dose 100 mg/kg), infustion of third-party donor-derived mesenchymal stem cells. All 56 patients with MSD-HSCT or HFD-HSCT achieved hematopoietic reconstitution. Among them, not only the recovery of neutrophils and platelets, but also the incidences of III-IV aGVHD, extensive cGVHD and TRT were not significantly different (the P value were 0.58, 0.61, 0.73, 0.73 and 0.67, respectively). After following-up for 32(2-66) months, 48 patients alive well, the 1-year overall survival rates were 86% in HFD-HSCT group and 89% in MSD-HSCT group, respectively (P=0.58). After HSCT using the modifed FC/ATG conditioning, patients with SAA achieved stable engraftment, low toxicity, mild GVHD and excellent outcomes. Furthermore, the HFD-HSCT achieved comparable outcomes to MSD-HSCT and may be served as an alternate therapy for patients with SAA.

  20. Executive Function, Visual Attention and the Cocktail Party Problem in Musicians and Non-Musicians

    PubMed Central

    Clayton, Kameron K.; Swaminathan, Jayaganesh; Yazdanbakhsh, Arash; Zuk, Jennifer; Patel, Aniruddh D.; Kidd, Gerald

    2016-01-01

    The goal of this study was to investigate how cognitive factors influence performance in a multi-talker, “cocktail-party” like environment in musicians and non-musicians. This was achieved by relating performance in a spatial hearing task to cognitive processing abilities assessed using measures of executive function (EF) and visual attention in musicians and non-musicians. For the spatial hearing task, a speech target was presented simultaneously with two intelligible speech maskers that were either colocated with the target (0° azimuth) or were symmetrically separated from the target in azimuth (at ±15°). EF assessment included measures of cognitive flexibility, inhibition control and auditory working memory. Selective attention was assessed in the visual domain using a multiple object tracking task (MOT). For the MOT task, the observers were required to track target dots (n = 1,2,3,4,5) in the presence of interfering distractor dots. Musicians performed significantly better than non-musicians in the spatial hearing task. For the EF measures, musicians showed better performance on measures of auditory working memory compared to non-musicians. Furthermore, across all individuals, a significant correlation was observed between performance on the spatial hearing task and measures of auditory working memory. This result suggests that individual differences in performance in a cocktail party-like environment may depend in part on cognitive factors such as auditory working memory. Performance in the MOT task did not differ between groups. However, across all individuals, a significant correlation was found between performance in the MOT and spatial hearing tasks. A stepwise multiple regression analysis revealed that musicianship and performance on the MOT task significantly predicted performance on the spatial hearing task. Overall, these findings confirm the relationship between musicianship and cognitive factors including domain-general selective attention and