77 FR 30592 - Open Meeting of the Taxpayer Advocacy Panel Bankruptcy Compliance Project Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-23

... Bankruptcy Compliance Project Committee will be held Thursday, June 28th at 8:00 a.m. to 4:30 p.m. and Friday... Bankruptcy Compliance Project Committee AGENCY: Internal Revenue Service (IRS) Treasury. ACTION: Notice of meeting. SUMMARY: An open meeting of the Taxpayer Advocacy Panel Bankruptcy Compliance Project Committee...

Solar Heating Retrofit of Military Family Housing

DTIC Science & Technology

1976-09-01

7625th Civil Engineering Squadron at the Air Fn!’ce Academy, the officers and men of the 12th Weather Squadron at Peterson Air Force Base , and the... based . 1-3 I j 4 ,,-.- cmD PA*& ARGNK FILMED CHAPTER 2 PROJECT OVERVIEW 2.1 Problem Addressed This project addresses the problem concerned with the...Force Academy are representative of what can be expected in the composition of the 2-1 real property base of Air Force installations in the future; c

Detailed Project Report. Small Beach Erosion Control Project. Broadkill Beach, Delaware.

DTIC Science & Technology

1972-02-01

this study. TABLE 3 ESTIMATED PROPERTY VALUES IN BROADKILL BEACH (July 1971) Beach Front Property* Entire Community Present Present Fair Value Fair ...between the 14th and 50th year reflect only the land, houses and utilities (minus salvage value estimated at 25% of the fair value ) that are located... Value $ $ 1,221,000 2,866,000 ftExcluding beach area. >4’ 5 11. The water entering Delaware Bay from Delaware River is polluted, but the degree of

On Campus Study of Florida Wildlife: Project Report.

ERIC Educational Resources Information Center

Newcomb-Jones, Carol

Ecosystem management is an integrated approach to managing Florida's biological and physical environments designed to maintain, protect, and improve the state's natural, managed, and human communities. This document contains activities designed for 4th-5th grade students that meet the guidelines of Florida's K-12 Science Framework to better…

Promoting Original Scientific Research and Teacher Training Through a High School Science Research Program: A Five Year Retrospective and Analysis of the Impact on Mentored 8th Grade Geoscience Students and the Mentors Themselves

NASA Astrophysics Data System (ADS)

Danch, J. M.

2015-12-01

In 2010 a group of 8th grade geoscience students participated in an extracurricular activity allowing them to conduct original scientific research while being mentored by students enrolled in a 3 - year high school Science Research program. Upon entering high school the mentored students themselves enrolled in the Science Research program and continued for 4 years, culminating with their participation in Science Research 4. This allowed them to continue conducting original scientific research, act as mentors to 8th grade geoscience students and to provide teacher training for both middle and high school teachers conducting inquiry-based science lessons. Of the 7 Science Research 4 students participating since 2010, 100% plan on majoring or minoring in a STEM - related field in college and their individual research projects have been been granted over 70 different awards and honors in science fair and symposia including a 3rd and 4th place category awards at two different international science fairs - the International Sustainable Energy Engineering and Environment Project (iSWEEP) and the International Science and Engineering Fair (ISEF). Science Research 4 students developed and conducted a Society for Science and the Public affiliated science fair for middle school students enrolled in an 8th grade honors geoscience program allowing over 100 students from 5 middle schools to present their research and be judged by STEM professionals. Students with research judged in the top 10% were nominated for participation in the National Broadcom MASTERS program which they successfully entered upon further mentoring from the Science Research 4 students. 8th grade enrollment in the Science Research program for 2015 increased by almost 50% with feedback from students, parents and teachers indicating that the mentorship and participation in the 8th grade science fair were factors in increasing interest in continuing authentic scientific research in high school.

Overview of acoustic measurements in South-East of France in 2012 during severe weather

NASA Astrophysics Data System (ADS)

Farges, Thomas; Blanc, Elisabeh; Le Pichon, Alexis; Defer, Eric; Fullekrug, Martin; Soula, Serge; van der Velde, Oscar

2013-04-01

CEA (Commissariat à l'Energie Atomique et aux Energies Alternatives) installed two acoustic networks in South-East of France. The first one was located in Observatoire Haute Provence in the framework of the ARISE European design project (arise-project.eu). It was composed of 4 microbarometers set in an equilateral triangle. The other network was located close to Uzès in the frame of the HyMeX (www.hymex.org) Special Operational Period from August 27th to November 16th. It was composed of 4 microbarometers and 4 microphones. From August to November 2012, several thunderstorms occurred close to these stations. The global thunder spectrum from 0.01 Hz to 250 Hz is studied using the microbarometer and microphone recordings. A very large thunderstorm, in August 30th-31st, produced more than 100 sprites over the south-western part of the Mediterranean Sea. Ten of them were dancing sprites. This kind of sprites can produce infrasound. This experiment offers a unique to triangulate sprites with infrasound measurements. Lastly, a tornado occurred in October 14th. This event will be analyzed with the data of both networks.

Early Stage Evolution of Nourished Beach under High-energy, Macro-tidal Environment

NASA Astrophysics Data System (ADS)

Liu, J. H.; Cai, F.; Zhang, Z. W.; Li, B.

2017-02-01

Beach planform evolution, profile equilibration and sediment grain size change have been studied during the first 4 months from 4th September to 24th December 2011 after the construction of beach nourishment project at Longfengtou Beach, Haitan Bay. Monthly beach profiles, shoreline surveys, sediment sampling and nearshore wave measurements were carried out after implementation of the 1.3km long nourishment project which was completed on 20th August 2011. This study indicates that: (1) rapid beach profile equilibration occurred in the early stage after the construction of the project. A null point was observed, which is equal to the height of mean high tide, basically kept dynamic stable during the process of profile evolution. Shoreface sediment accumulated beneath the height of this point while erosion happened above it, the slope between the beach berm and the landward edge of low tidal zone became more gradual accompanied with seaward transportation of beach sediment. The velocity of beach slope adjustment in earlier period is faster than later. (2) Beach planform adjustment initiated simultaneously with the combination of the process of profile equilibration and longshore sediment transport. Shoreline retreated with an average distance of 11.1m and maximum of 31.02m from 4th September to 24th December, erosion in the south part was more serious than in the north, and 3 erosion hot spots were found along the coast. (3) Sediment redistributed with cross-shore profile equilibration, it showed a pattern across beach profile as medium sand (0.4-0.5mm) in beach berm, smaller (0.3-0.4mm) in high and middle tidal zone, coarse sand(0.6-1mm) in beach slope transitional zone, fine sand(0.1-0.25mm) in low tidal zone. The sediment grain size change of foreshore was rapidly response to the passage of storm surge.

Progress Report 18 for the Period February to July 1981 and Proceeidngs of the 18th Project Integration Meeting

NASA Technical Reports Server (NTRS)

1981-01-01

Progress in the low cost solar array project during the period February to July 1981 is reported. Included are: (1) project analysis and integration; (2) technology development in silicon material, large area silicon sheer and encapsulation; (3) process development; (4) engineering, and operations.

Problem Solving in Practice

ERIC Educational Resources Information Center

Greene, Kim; Heyck-Williams, Jeff; Timpson Gray, Elicia

2017-01-01

Problem solving spans all grade levels and content areas, as evidenced by this compilation of projects from schools across the United States. In one project, high school girls built a solar-powered tent to serve their city's homeless population. In another project, 4th graders explored historic Jamestown to learn about the voices lost to history.…

Performance simulation of a detector for 4th generation photon sources: The AGIPD

NASA Astrophysics Data System (ADS)

Potdevin, G.; Trunk, U.; Graafsma, H.; Agipd Consortium

2009-08-01

Future 4th generation photon sources, such as the European XFEL based in Hamburg, will deliver around 1012 X-ray photons in less than 100 fs with full lateral coherence. These new sources will offer unprecedented possibilities in photon science. The high peak brilliance, combined with a 5 MHz repetition rate poses very high demands for the 2D detectors. In order to provide appropriate detectors during XFEL startup, three dedicated development projects have been initiated, one of them being the Adaptive Gain Integrating Pixel Detector (AGIPD) project which is a collaborative effort between DESY, PSI, University of Bonn, and University of Hamburg. An essential part of the AGIPD project is the development of a simulation tool for the complete detection system. The simulation tool as well as preliminary simulations of the detector characteristics is presented.

First-principles study of the elastic and thermodynamic properties of thorium hydrides at high pressure

NASA Astrophysics Data System (ADS)

Xiao-Lin, Zhang; Yuan-Yuan, Wu; Xiao-Hong, Shao; Yong, Lu; Ping, Zhang

2016-05-01

The high pressure behaviors of Th4H15 and ThH2 are investigated by using the first-principles calculations based on the density functional theory (DFT). From the energy-volume relations, the bct phase of ThH2 is more stable than the fcc phase at ambient conditions. At high pressure, the bct ThH2 and bcc Th4H15 phases are more brittle than they are at ambient pressure from the calculated elastic constants and the Poisson ratio. The thermodynamic stability of the bct phase ThH2 is determined from the calculated phonon dispersion. In the pressure domain of interest, the phonon dispersions of bcc Th4H15 and bct ThH2 are positive, indicating the dynamical stability of these two phases, while the fcc ThH2 is unstable. The thermodynamic properties including the lattice vibration energy, entropy, and specific heat are predicted for these stable phases. The vibrational free energy decreases with the increase of the temperature, and the entropy and the heat capacity are proportional to the temperature and inversely proportional to the pressure. As the pressure increases, the resistance to the external pressure is strengthened for Th4H15 and ThH2. Project supported by the Long-Term Subsidy Mechanism from the Ministry of Finance and the Ministry of Education of China.

Microseismic monitoring during Hydraulic stimulation in Pohang (Korea) for EGS pilot project

NASA Astrophysics Data System (ADS)

Kim, M.; Yoon, B.; Lee, C.; Park, K. G.; Yoon, W. S.; Song, Y.; Lee, T. J.

2017-12-01

Since the geothermal anomaly in the Pohang area has been reported in 1960s, various geological and geophysical surveys have been conducted by Korea Institute of Geoscience and Mineral Resources (KIGAM) including gravity, seismic, airborne magnetic and magneto-telluric surveys. Based on these explorations, the Enhanced Geothermal System (EGS) pilot project has been carried out in Pohang since the end of 2010. One vertical well (PX-2, MD 4,348 m) and one deviated well (PX-1, MD 4,362 m) have been drilled in granite rock for the EGS. Microseismic (MS) monitoring is the best way to understand how the fracture grows during the hydraulic stimulation. KIGAM has set up 9 shallow borehole stations (100-130 m), 4 surface stations and two borehole geophones (1,350 and 1,550 m deep) within 5 km radius from injection well for the MS monitoring during hydraulic stimulation. The first hydraulic stimulation started on January 29th to February 20th, 2016 at PX-2 and the second stimulation was conducted in PX-1 from December 15th, 2016 to January 11th, 2017. Several hundreds of MS events occurred during stimulation and the biggest event was ML 2.3 during the shut in period of the second stimulation. Based on the results of the MS monitoring, a soft stimulation is scheduled at PX-1 in cooperation with one of the European Horizon2020 project, DESTRESS (Demonstration of soft stimulation treatments of geothermal reservoirs). We will present the MS monitoring system in Pohang and the data of the stimulation with the MS monitoring results. We believe that the data from Pohang will improve the understanding of seismic behavior due to hydraulic stimulation in crystalline rocks and also will contribute to success of the Pohang EGS project.

17th Annual School Construction Report, 2012

ERIC Educational Resources Information Center

Abramson, Paul

2012-01-01

The 2012 "School Planning & Management"'s 17th Annual School Construction Report reports over the last two years although school construction had fallen from previous highs, the pipeline of projects funded before the recession was still full. And so, in 2009 total construction was a solid $16.4 billion. But the pipeline is not being…

Port Arthur Alive: Exploring Past and Present, 4. Eyewitness.

ERIC Educational Resources Information Center

Tasmanian Education Dept., Hobart (Australia).

This document presents part 4 of a five part project in which students of the Tasmanian region of Australia are invited to explore the history of Port Arthur, a 19th century penal colony located in Tasmania. The project is based on three ideas: (1) studying history can be educational and enjoyable; (2) imagination is an essential part of studying…

A Window on Science: Exploring the JASON Project and Student Conceptions of Science.

ERIC Educational Resources Information Center

Moss, David M.

2003-01-01

Describes how the JASON project was implemented in a self-contained 4th grade classroom and examines this project within the overall context of student-scientist partnership (SSP) models of science education reform. Examines changes in student conceptions of the nature of science as a result of participating in science. (Contains 24 references.)…

76 FR 40447 - Notice of Proposed Buy America Waiver To Allow Bidder To Certify Compliance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-08

... Subway project to certify compliance with Buy America. The bidder certified non-compliance based on a... Second Avenue Subway project. If granted, this waiver would be limited to the procedural aspects of the... for a contract to construct the 86th Street Station for its Second Avenue Subway project, a $4.8...

The 17th Project Integration Meeting

NASA Technical Reports Server (NTRS)

Mcdonald, R. R.

1981-01-01

Progress made by the Low-Cost Solar Array Project during the period September 1980 to February 1981 is described. Included are reports on project analysis and integration; technology development in silicon material, large-area silicon sheet and encapsulation; production process and equipment development; engineering, and operations. A report on and copies of visual presentations made at the Project Integration Meeting held at Pasadena, California on February 4 and 5, 1981 are also included.

Tarnished Armor Erosion of Military Ethics

DTIC Science & Technology

1988-03-23

UNCLASSIFC-ED ?JSAWC MILITAFY STUD’ FS PROGRA.M PAPER Th4 vlev: expressed La th 028paPer are thane of the"athor antd do Vot Dece~ssacl 7 reflect the...NDTV7DUA1L STUDY PROjECT bitoF byAvIbit Lieutenant Colonel Bruce Allen M4a~ sOn , Eli Colonel Timothy Tatum ?roject Adv;iser DISTRIZUTtff STATU=~ At APPIOVeC...activity began to ener,. a od; de was associated with a personage who ultimately becare a ,a p4ayir in the ’ark intrigue. Soon there was connectivity, and

TH-E-17A-09: High Quality and Artifact-Free 4D Cone Beam CT and Its Application in Adaptive Treatment Planning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Niu, K; Li, K; Smilowitz, J

2014-06-15

Purpose: To develop a high quality 4D cone beam CT (4DCBCT) method that is immune to patient/couch truncations and to investigate its application in adaptive replanning of lung XRT. Methods: In this study, IRB-approved human subject CBCT data was acquired using a Varian on-board imager with 1 minute rotation time. The acquired projection data was retrospectively sorted into 20 respiratory phase bins, from which 4DCBCT images with high SNR and high temporal resolution were generated using Prior Image Constrained Compressed Sensing (PICCS). Couch and patient truncations generate strong data inconsistency in the projection data and artifacts in the 4DCBCT image.more » They were addressed using an adaptive PICCS method. The artifact-free PICCS-4DCBCT images were used to generate adaptive treatment plans for the same patient at the 10th (day 21) and 30th (day 47) fractions. Dosimetric impacts with and without PICCS- 4DCBCT were evaluated by isodose distributions, DVHs, and other dosimetric factors. Results: The adaptive PICCS-4DCBCT method improves image quality by removing residue truncation artifacts; measured universal image quality increased 37%. The isodose lines and DVHs with PICCS-4DCBCT-based adaptive replanning were significantly more conformal to PTV than without replanning due to changes in patient anatomy caused by progress of the treatment. The mean dose to PTV at the 10th fraction was 63.1Gy with replanning and 64.2Gy without replanning, where the prescribed dose was 60Gy, in 2Gy × 30 fractions. The mean dose to PTV at the 30th fraction was 61.6Gy with replanning and 64.9Gy without replanning. Lung V20 was 37.1%, 41.9% and 43.3% for original plan, 10th fraction plan and 30th fraction plan; with re-planning, Lung V20 was 37.1%, 32%, 27.8%. Conclusion: 4DCBCT imaging using adaptive PICCS is able to generate high quality, artifact-free images that potentially can be used to create replanning for improving radiotherapy of the lung. K Niu, K Li, J Smilowitz: Nothing to Disclose. G Chen: General Electric Company Research funded, Siemens AG Research funded, Varian Medical Systems Research funded, Hologic Research funded.« less

Literacy and Emotions: Data Analysis from the Dudelange Project.

ERIC Educational Resources Information Center

Berg, Charles; Lick, Paulette

A study focused on the relationship between emotions and literacy achievements. It begins with a mention of the theoretical contributions which backed up the study. In the Dudelange project survey (4th graders), the following literacy variables are available: word recognition, two different measures for reading comprehension, spelling, vocabulary…

77 FR 20006 - Reports and Updates on Programs and Research Projects

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-03

... ARCTIC RESEARCH COMMISSION Reports and Updates on Programs and Research Projects Notice is hereby given that the U.S. Arctic Research Commission will hold its 97th meeting in Montreal, Quebec, Canada... meeting. (3) Commissioners and staff reports. (4) Discussion and presentations concerning Arctic research...

Actas de la 4th mesa redonda sobre investigacion en "Lenguas Extranjeras" en la Universidad Autonoma Metropolitana 1996. (Proceedings from the 4th Roundtable on Investigation in Foreign Languages in the Autonomous Metropolitan University 1996).

ERIC Educational Resources Information Center

Zoreda, Margaret Lee, Comp.; Diop, Mamoudou Si, Comp.; Vivaldo Lima, Javier, Comp.

The articles included in this volume were selected as exemplary papers from the conference in Mexico. The goal of the forum was to provide an opportunity for researchers from the three branches of the Universidad Autonoma Metropolitana (UAM) to meet and discuss research projects currently in progress at the university. The works presented here…

Contemporary Options for Longitudinal Follow-Up: Lessons Learned from a Cohort of Urban Adolescents

ERIC Educational Resources Information Center

Tobler, Amy L.; Komro, Kelli A.

2011-01-01

This study reports efforts to locate and survey participants in Project Northland Chicago (PNC), a longitudinal, group-randomized trial of an alcohol preventive intervention for racial/ethnic minority, urban, early-adolescents, 3-4 years following the end of the intervention. Data were collected annually among students from 6th-8th grade and then…

Knocking at the College Door: Projections of High School Graduates by State and Race/Ethnicity, 1992-2022. Wyoming

ERIC Educational Resources Information Center

Western Interstate Commission for Higher Education, 2008

2008-01-01

The 7th edition of this publication provides updated projections of high school graduates for each year and each state (plus the District of Columbia) through 2022. The profile breaks down the projections by major racial and ethnic groups: (1) American Indian/Alaska Native; (2) Asian/Pacific Islander; (3) Black, non-Hispanic; (4) Hispanic; and (5)…

Knocking at the College Door: Projections of High School Graduates by State and Race/Ethnicity, 1992-2022. Alaska

ERIC Educational Resources Information Center

Western Interstate Commission for Higher Education, 2008

2008-01-01

The 7th edition of this publication provides updated projections of high school graduates for each year and each state (plus the District of Columbia) through 2022. The profile breaks down the projections by major racial and ethnic groups: (1) American Indian/Alaska Native; (2) Asian/Pacific Islander; (3) Black, non-Hispanic; (4) Hispanic; and (5)…

Knocking at the College Door: Projections of High School Graduates by State and Race/Ethnicity, 1992-2022. Louisiana

ERIC Educational Resources Information Center

Western Interstate Commission for Higher Education, 2008

2008-01-01

The 7th edition of this publication provides updated projections of high school graduates for each year and each state (plus the District of Columbia) through 2022. The profile breaks down the projections by major racial and ethnic groups: (1) American Indian/Alaska Native; (2) Asian/Pacific Islander; (3) Black, non-Hispanic; (4) Hispanic; and (5)…

Knocking at the College Door: Projections of High School Graduates by State and Race/Ethnicity, 1992-2022. Mississippi

ERIC Educational Resources Information Center

Western Interstate Commission for Higher Education, 2008

2008-01-01

The 7th edition of this publication provides updated projections of high school graduates for each year and each state (plus the District of Columbia) through 2022. The profile breaks down the projections by major racial and ethnic groups: (1) American Indian/Alaska Native; (2) Asian/Pacific Islander; (3) Black, non-Hispanic; (4) Hispanic; and (5)…

The Pleasant Valley School: A Living History Project

ERIC Educational Resources Information Center

Buckner, David L.; Brown, Pamela U.; Curry, John

2010-01-01

This article discusses the Pleasant Valley School, located in Stillwater, Oklahoma, which is now a living history project where contemporary 4th grade students throughout Oklahoma have the opportunity to spend a day as students did in a turn of the century one-room schoolhouse, complete with coal heating, ink wells, and "McGuffey…

Project Physics Text 4, Light and Electromagnetism.

ERIC Educational Resources Information Center

Harvard Univ., Cambridge, MA. Harvard Project Physics.

Optical and electromagnetic fundamentals are presented in this fourth unit of the Project Physics text for use by senior high students. Development of the wave theory in the first half of the 19th Century is described to deal with optical problems at the early stage. Following explanations of electric charges and forces, field concepts are…

TNT Equivalency Testing of Chemical Mixtures in Continuous TNT Manufacturing

DTIC Science & Technology

1980-08-01

RONALD RAPE JOSEPH MAVEC RICHARD JOYCE IIT RESEARCH INSTITUTE 10 WEST35TH STREET CHICAGO. IL 60616 PAUL PRICE. PROJECT LEADER ARRADCOM. DOVER. NEW...AUTHORfs; Ronald Pape, Joseph Mavec, Richard Joyce, IIT Research Institute Paul Price, Project Leader, ARRADCOM 8. CONTRACT OR GRANT NUMBERfs...r-4 (0 ^ o s •H ^ <U XI 4J C-H •r4 1-1 i-l 1-1 >. a; X) U to •rl U «c U-l o 60 C *J •H C x m^: •^ E c B 4J CC M 4-J 4-1

Knocking at the College Door: Projections of High School Graduates by State and Race/Ethnicity, 1992-2022. District of Columbia

ERIC Educational Resources Information Center

Western Interstate Commission for Higher Education, 2008

2008-01-01

The 7th edition of this publication provides updated projections of high school graduates for each year and each state (plus the District of Columbia) through 2022. The profile breaks down the projections by major racial and ethnic groups: (1) American Indian/Alaska Native; (2) Asian/Pacific Islander; (3) Black, non-Hispanic; (4) Hispanic; and (5)…

Knocking at the College Door: Projections of High School Graduates by State and Race/Ethnicity, 1992-2022. South Dakota

ERIC Educational Resources Information Center

Western Interstate Commission for Higher Education, 2008

2008-01-01

The 7th edition of this publication provides updated projections of high school graduates for each year and each state (plus the District of Columbia) through 2022. The profile breaks down the projections by major racial and ethnic groups: (1) American Indian/Alaska Native; (2) Asian/Pacific Islander; (3) Black, non-Hispanic; (4) Hispanic; and (5)…

Distribution and ultrastructure of dopaminergic neurons in the dorsal motor nucleus of the vagus projecting to the stomach of the rat.

PubMed

Hayakawa, Tetsu; Takanaga, Akinori; Tanaka, Koichi; Maeda, Seishi; Seki, Makoto

2004-04-23

Almost all parasympathetic preganglionic motor neurons contain acetylcholine, whereas quite a few motor neurons in the dorsal motor nucleus of the vagus (DMV) contain dopamine. We determined the distribution and ultrastructure of these dopaminergic neurons with double-labeling immunohistochemistry for tyrosine hydroxylase (TH) and the retrograde tracer cholera toxin subunit b (CTb) following its injection into the stomach. A few TH-immunoreactive (TH-ir) neurons were found in the rostral half of the DMV, while a moderate number of these neurons were found in the caudal half. Most of the TH-ir neurons (78.4%) were double-labeled for CTb in the half of the DMV caudal to the area postrema, but only a few TH-ir neurons (5.5%) were double-labeled in the rostral half. About 20% of gastric motor neurons showed TH-immunoreactivity in the caudal half of the DMV, but only 0.3% were TH-ir in the rostral half. In all gastric motor neurons, 8.1% were double-labeled for TH. The ultrastructure of the TH-ir neurons in the caudal DMV was determined with immuno-gold-silver labeling. The TH-ir neurons were small (20.4 x 12.4 microm), round or oval, and contained numerous mitochondria, many free ribosomes, several Golgi apparatuses, a round nucleus and a few Nissl bodies. The average number of axosomatic terminals per section was 4.0. More than half of them contained round synaptic vesicles and made asymmetric synaptic contacts (Gray's type I). Most of the axodendritic terminals contacting TH-ir dendrites were Gray's type I (90%), but a few contained pleomorphic vesicles and made symmetric synaptic contacts (Gray's type II).

75 FR 9573 - Minnkota Power Cooperative, Inc: Bemidji-Grand Rapids 230kV Transmission Project

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-03

... Rapids 230kV Transmission Project AGENCY: Rural Utilities Service, USDA. ACTION: Notice of Availability... copy of the Draft EIS may be viewed online at the following Web sites: http://www.usda.gov/rus/water..., Longville, MN 56655; Walker Public Library, 207 4th St., Walker, MN 56484; Bovey Public Library--Village...

"We Are Wyoming": An Arts Integrated Teaching and Inquiry Project

ERIC Educational Resources Information Center

Trent, Allen; Moran, Peter

2018-01-01

This article is about a year-long teaching and research project conducted with 696 4th graders (mostly 10-year olds) and their 36 teachers in Wyoming/USA. The researchers employed an action research approach. They planned and taught a two-day, Wyoming-themed, interdisciplinary unit, "We Are Wyoming", which integrated Social Studies,…

Math Manipulatives to Increase 4th Grade Student Achievement

ERIC Educational Resources Information Center

Couture, Katie

2012-01-01

This research project was completed with twenty-nine fourth grade students from Shawnee Elementary, a school in the Chippewa Valley School District. It began in April 2012 and the data collection was completed by June 2012. The purpose of this project was to see if utilizing math manipulatives in an elementary classroom will increase student…

Implementation of the interdisciplinary curriculum Teaching and Assessing Communicative Competence in the fourth academic year of medical studies (CoMeD).

PubMed

Mortsiefer, Achim; Rotthoff, Thomas; Schmelzer, Regine; Immecke, J; Ortmanns, B; in der Schmitten, J; Altiner, A; Karger, André

2012-01-01

Implementation of a longitudinal curriculum for training in advanced communications skills represents an unmet need in most German medical faculties, especially in the 4rth and 5th years of medical studies. The CoMeD project (communication in medical education Düsseldorf) attempted to establish an interdisciplinary program to teach and to assess communicative competence in the 4th academic year. In this paper, we describe the development of the project and report results of its evaluation by medical students. Teaching objectives and lesson formats were developed in a multistage process. A teaching program for simulated patients (SP) was built up and continuous lecturer trainings were estabilshed. Several clinical disciplines co-operated for the purpose of integrating the communication training into the pre-existing clinical teaching curriculum. The CoMeD project was evaluated using feedback-forms after each course. Until now, six training units for especially challenging communication tasks like "dealing with aggression" or "breaking bad news" were implemented, each unit connected with a preliminary tutorial or e-learning course. An OSCE (objective structured clinical examination) with 4 stations was introduced. The students' evaluation of the six CoMeD training units showed the top or second-best rating in more than 80% of the answers. Introducing an interdisciplinary communication training and a corresponding OSCE into the 4th year medical curriculum is feasible. Embedding communication teaching in a clinical context and involvement of clinicians as lecturers seem to be important factors for ensuring practical relevance and achieving high acceptance by medical students.

Project VALOR: Trajectories of Change in PTSD in Combat-Exposed Veterans

DTIC Science & Technology

2015-10-01

Affairs electronic records of Iraq and Afghanistan veterans. Journal of consulting and clinical psychology , 82(4), 569. PRESENTATIONS Barretto...Veterans. Poster presented at the 49th Annual Meeting of the Association of Behavioral and Cognitive Therapies, Chicago, IL. Bovin, M. J., Marx, B...comparison of Operation Iraqi Freedom Deployment Phases. Poster presented at the 49th Annual Meeting of the Association of Behavioral and Cognitive

Seminar on the Acquisition of Latin American Library Materials (15th, Toronto, Ontario, Canada, June 23-26, 1970). Final Report and Working Papers, Volume II.

ERIC Educational Resources Information Center

Benson, Susan Shattuck: Bresie, Mayellen

Volume 2 contains 13 working papers from the 15th Seminar on Acquisition of Latin American Library Materials. The papers are: (1) A Report on Bibliographic Activities; (2) Microfilm Projects Newsletter; (3) Role of Latin American Legal Material in the Social Science Research Library; (4) A description of sources for Legal and Social Science…

Projecting water resources changes in potential large-scale agricultural investment areas of the Kafue River Basin in Zambia

NASA Astrophysics Data System (ADS)

Kim, Y.; Trainor, A. M.; Baker, T. J.

2017-12-01

Climate change impacts regional water availability through the spatial and temporal redistribution of available water resources. This study focuses on understanding possible response of water resources to climate change in regions where potentials for large-scale agricultural investments are planned in the upper and middle Kafue River Basin in Zambia. We used historical and projected precipitation and temperature to assess changes in water yield, using the Soil and Water Assessment Tool (SWAT) hydrological model. Some of the Coupled Model Intercomparison Project Phase 5 (CMIP5) climate model outputs for the Representative Concentration Pathway (RCP) 4.5 and 8.5 scenarios project a temperature warming range from 1.8 - 5.7 °C over the region from 2020 to 2095. Precipitation projection patterns vary monthly but tend toward drier dry seasons with a slight increase in precipitation during the rainy season as compared to the historical time series. The best five calibrated parameter sets generated for the historical record (1965 - 2005) were applied for two future periods, 2020 - 2060 and 2055 - 2095, to project water yield change. Simulations projected that the 90th percentile water yield would be exceeded across most of the study area by up to 800% under the medium-low (RCP4.5) CO2 emission scenario, whereas the high (RCP8.5) CO2 emission scenario resulted in a more spatially varied pattern mixed with increasing (up to 500%) and decreasing (up to -54%) trends. The 10th percentile water yield indicated spatially varied pattern across the basin, increasing by as much as 500% though decreasing in some areas by 66%, with the greatest decreases during the dry season under RCP8.5. Overall, available water resources in the study area are projected to trend toward increased floods (i.e. water yields far exceeding 90th percentile) as well as increasing drought (i.e. water yield far below 10th percentile) vulnerability. Because surface water is a primary source for agriculture in this region, planning must focus on simulating the potential range in spatial and temporal variability of water resources for different agricultural production schemes, their infrastructure requirements, and attendant influence on water resources in the basin.

76 FR 2947 - Notice of Final Federal Agency Actions on Proposed Highway in Minnesota

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-18

... combined segment of Trunk Highway (TH) 23 and U.S. Highway 71. The proposed project is from the TH 294 and TH 23/71 divergence on the south to the divergence of the TH 23 and U.S. Highway 71 on the north in... project in Minnesota: TH 23/71 from the TH 294 and TH 23/71 divergence on the south to the divergence of...

Environmental Science: 49 Science Fair Projects. Science Fair Projects Series.

ERIC Educational Resources Information Center

Bonnet, Robert L.; Keen, G. Daniel

This book contains 49 science fair projects designed for 6th to 9th grade students. Projects are organized by the topics of soil, ecology (projects in habitat and life cycles), pests and controls (projects in weeds and insects), recycling (projects in resources and conservation), waste products (projects in decomposition), microscopic organisms,…

Nd:YAG pulsed-wave laser as support therapy in the treatment of teno-desmopathies of athlete horses: a clinical and experimental trial

NASA Astrophysics Data System (ADS)

Fortuna, Damiano; Rossi, Giacomo; Paolini, Cesare; Magi, Alberto; Losani, Fabrizio; Fallaci, Simone; Pacini, Franco; Porciani, Chiara; Sandler, Anna; Dalla Torre, Riccarda; Pinna, Stefania; Venturini, Antonio

2002-10-01

The ultrasonic evolution of tendinous repair envisages the recovery of ecogenicity: "reparative phase", followed by the realignment of the collagen fibres: "rehabilitative phase". The primary objective was to verify the safety and efficacy of Nd:YAG pulsed wave on teno- desmopathies of horses. Secondary to shorten "reparative phase" for to provide more time for "rehabilitative phase". The study has been divided into two investigations: experimental and clinical. In the experimental investigation, on 3 meat horses, the safety and tolerance of a power laser (35 W/cm2, 25 J/cm2) was investigated. The clinical investigation was performed on 79 sport horses through randomized double-blind. All subjects (Controls and Treated) received, on the subskin above the tendon lesion, the same local infiltration of immunostimulant. The results indicates that the High Intensity Laser Therapy (HILT) is safe and tolerated. It is able of reducing, in significative way, the "reparative phase", with a lower percentage of relapse (20% Treated and 40% Controls), but it is not able to reduce the time of the "rehabilitative phase".

Water quality standards for the protection of human health and aquatic ecosystems in Korea: current state and future perspective.

PubMed

Kwak, Jin Il; Nam, Sun-Hwa; An, Youn-Joo

2018-02-01

Since the Korean Ministry of the Environment established the Master Plan for Water Environment (2006-2015), the need to revise the water quality standards (WQSs) has driven government projects to expand the standards for the protection of human health and aquatic ecosystems. This study aimed to provide an historical overview of how these WQSs were established, amended, and expanded over the past 10 years in Korea. Here, major projects related to national monitoring in rivers and the amendment of WQSs were intensely reviewed, including projects on the categorization of hazardous chemicals potentially discharged into surface water, the chemical ranking and scoring methodology for surface water (CRAFT, Chemical RAnking of surFace water polluTants), whole effluent toxicity (WET) management systems, the 4th, 5th, and 6th revisions of the water quality standards for the protection of human health, and efforts toward developing the 7th revision. In this review, we assimilated the past and current status as well as future perspectives of Korean surface WQSs. This research provides information that aids our understanding of how surface WQSs have been expanded, and how scientific approaches to ensure water quality have been applied at each step of the process in Korea.

Evidence for the role of hindbrain orexin-1 receptors in the control of meal size

PubMed Central

Parise, Eric M.; Lilly, Nicole; Kay, Kristen; Dossat, Amanda M.; Seth, Rohit; Overton, J. Michael

2011-01-01

Hypothalamic orexin neurons project to the hindbrain, and 4th-ventricle intracerebroventricular (4th-icv) injection of orexin-A treatment increases food intake. We assessed the effects of hindbrain orexin-A and the orexin-1-receptor antagonist SB334867 on meal pattern in rats consuming standard chow. When injected 4th-icv shortly before dark onset, lower doses of orexin-A increased food intake over a 2-h period by increasing the size of the first meal relative to vehicle, whereas the highest dose increased food intake by causing the second meal to be taken sooner. Conversely, hindbrain SB334867 reduced food intake by decreasing the size of the first meal of the dark phase. We also examined the effects of 4th-icv orexin-A and SB334867 on locomotor activity. Only the highest dose of orexin-A increased activity, and SB334867 had no effect. In addition, hindbrain SB334867 induced c-Fos in the nucleus of the solitary tract. These data support the suggestion that endogenous hindbrain orexin-A acts to limit satiation. Both orexin-A and the pancreatic satiation hormone amylin require an intact area postrema to affect food intake, so we asked whether 4th-icv orexin-A impairs the satiating effect of peripheral amylin treatment. Amylin reduced the size of the first meal of the dark cycle when rats were pretreated with 4th-icv saline, yet amylin was ineffective after 4th-icv orexin-A pretreatment. Using double-label immunohistochemistry, we determined that some orexin-A fibers in the area postrema are located in proximity to amylin-responsive neurons. Therefore, hindbrain orexin-A may increase food intake, in part, by reducing the ability of rats to respond to amylin during a meal. PMID:21957165

Pacific Circle Consortium: A Regional Project of OECD/CERI. Report of Annual Conference (6th, Hiroshima, Japan, September 27-October 4, 1982).

ERIC Educational Resources Information Center

Organisation for Economic Cooperation and Development, Paris (France). Centre for Educational Research and Innovation.

Pacific region countries reported on their 1982 cooperative activities in education, including exchange and curriculum development projects, aimed at improving intercultural understanding. The first part of the report describes what happened at the sessions; the second part contains the appendices. Various countries--Australia, Canada, Japan, New…

Proceedings of the Annual Major Range and Test Facility Base (MRTFB) environmental Workshop (4th) Held in Alexandria, Virginia on 26-28 April 1994

DTIC Science & Technology

1994-07-01

House 1730-1900 Examples of Successful Strategies: Maj. Richard Travis, TECOM 1- ’-4 I I Workshop Agenda, 27 April 1994 (Wednesday) 5 0800-0830 Coffee ...NAWC-WD (China Lake)-SERDP Update, requirements coordination Mr. Lance VanderZyle, Yuma Proving Ground -Environmental Simulation Model Project Dr. Regina...maintenance of buildings and grounds . Planting projects must clearly identify vegetation to be planted. For example, if the primary purpose of an urban mee

76 FR 21712 - Meeting of the Ocean Research and Resources Advisory Industry Sub-Panel

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-18

... creative problem-solving to overcome impediments to industry progress toward deploying operational projects... held at the Consortium for Ocean Leadership, 1201 New York Avenue, NW., 4th Floor, Washington, DC 20005...

Wind-fuel cell hybrid project in rural Alaska

DOE Office of Scientific and Technical Information (OSTI.GOV)

David Lockard

2000-02-18

This is a summary of the work performed on the Wind-Fuel Cell Hybrid Project: (1) On October 5th, Tim Howell of the Golden Field Office and Tom Anderson of Battelle Labs arrived in Anchorage. They met with David Lockard, Project Manager, and Percy Frisby, Director of the Alaska Rural Energy Programs Group. (2) On October 6th, Tim, Tom and David flew to Nome to inspect the proposed wind turbine site and meet with John Handeland, Director of the Nome Joint Utility System. They visited the proposed site as well as several private, residential-sized wind turbines operating in the Nome area.more » (3)Tim and Tom flew to Unalaska on October 7th to meet with Mike Golat, City of Unalaska Public Utility Director, and to inspect the proposed wind turbine sites at Pyramid Creek and Pyramid Valley. (4)Tim sent a scoping letter on December 17th to a variety of local, state and federal agencies requesting comments on the proposed wind turbine project. (5) David discussed this project with Marc Schwartz and Gerry Nix at NREL. Marc provided David with a list of wind prospectors and meteorologists. (6) Tom raised the question of FAA permits for structures over 200 feet tall. Gerry provided information on NREL's experience with FAA permitting on other projects. David summarized the potential turbine choices and heights in a spreadsheet and initiated contact with the Alaska region FAA office regarding the permitting process. (7) David responded to a list of design questions from Tom regarding the project foundations, power output, and size for use in developing the environmental assessment. (8) David tried to get wind data for the Nome Anvil Mountain White Alice site from the Corps of Engineers and the Air Force, but was not able to find any. (9) David solicited quotes from vendors of wind monitoring equipment and provided cost information to Doug Hooker, federal grant manager in preparation for ordering the equipment.« less

ESTIMATE OF GLOBAL METHANE EMISSIONS FROM LANDFILLS AND OPEN DUMPS

EPA Science Inventory

The report presents an empirical model to estimate global methane (CH4) emissions from landfills and open dumps based on EPA data from landfill gas (LFG) recovery projects. The EPA CH4 estimates for 1990 range between 19 and 40 teragrams (10 to the 12th power) per year (Tg/yr), w...

A Study on the Efficacy of Project-Based Learning Approach on Social Studies Education: Conceptual Achievement and Academic Motivation

ERIC Educational Resources Information Center

Ilter, Ilhan

2014-01-01

In this research, an experimental study was carried out in social studies 4th grade students to develop students' conceptual achievement and motivation to succeed academically. The study aims to investigate the effectiveness of project-based learning (PBL) in social studies. A quasi-experimental research design (pre- and posttest) was used in the…

Projections of the Male Youth Population and Enlistment Propensity by Army Recruiting Battalion, 1980-1995

DTIC Science & Technology

1987-10-01

41F Kansas bity, NO 4G Little Rock, AR 4H ’p New OrIeans, LA 41 p. Oklahma City, CK 4J San Antonio, TX 4K 4th Chicago, IL 5A Midwest Cincinnati, CH ...2167 1 2179 1 2178 1 2173 1 2220 1 2275 1 ICAT IV-V NONHS ! 7300 7498 7603 7757 7839 7845 7874 1 8042 1 8230 I

[Analysis on research projects for acupuncture and moxibustion supported by NSFC during the 11th 5-year-plan].

PubMed

Zhao, Chang-Long; Jing, Xiang-Hong; Li, Yu-Qing; Li, Liang; Rong, Pei-Jing; Wang, Chang-En

2012-08-01

In the present paper, the authors introduce the approved and finished research projects for acupuncture and moxibustion therapies supported by the National Natural Science Foundation of China (NSFC) during the 11th 5-year-plan. A total of 194 research projects were subsidized by NSFC from 2006 to 2010. These projects include 6 aspects: meridian-collaterals, acupoint theory, acupuncture analgesia, mechanisms underlying improvement of different clinical problems, clinical trials, and moxibustion therapy. The research on acupoints has been becoming a new hotspot in recent years. Majority of the research projects focus on the mechanism of acu-moxibustion underlying improvement of different clinical problems, while fewer projects on clinical trials. During the 11th 5-year-plan, 119 projects were completed; most of them involved meridian-collateral theory, acupoint theory, mechanism of acu-moxibustion underlying improvement of clinical problems and acupuncture manipulations. Following analysis of the finished research projects, we find that 1) many neurobiological methods and techniques are commonly used in the research on meridian-collateral theory; 2) the research on acupoint theory is changing from observing the local morphological structure to identifying characteristics of the regional activated receptors, particularly under the circumstances of visceral pathological conditions and efficacies of acupoints; 3) researches on the underlying mechanism of acu-moxibusiton for improving clinical disorders mainly focused on its cerebral protective effects against cerebral ischemia, in addition, researches about other diseases on clinical conditions have been also carried out, but the related mechanisms are far from understanding; 4) In many research projects, various new methods and techniques, such as fMRI, position emission tomography, genomics, proteomics, molecular biology, nerve stem cell, etc. were widely used; 5) Randomized controlled multi-center clinical trials are definitely insufficient. Only two clinical projects were finished during the 11th 5-year-plan. Moreover, it should be noted that in the subject of acu-moxibustion, independent innovation researches are fewer; the foundation of competitive ability is relatively weaker; the supporting conditions for finishing the research projects are poorer in some institutes or districts; and the interrelations among the theoretical, experimental and clinical researches are not intimately close, leading to relative lag in the subject development.

AEOSS design guide for system analysis on Advanced Earth-Orbital Spacecraft Systems

NASA Technical Reports Server (NTRS)

Lee, Hwa-Ping

1990-01-01

Advanced Earth Orbital Spacecraft System (AEOSS) enables users to project the requried power, weight, and cost for a generic earth-orbital spacecraft system. These variables are calculated on the component and subsystem levels, and then the system level. The included six subsystems are electric power, thermal control, structure, auxillary propulsion, attitude control, and communication, command, and data handling. The costs are computed using statistically determined models that were derived from the flown spacecraft in the past and were categorized into classes according to their functions and structural complexity. Selected design and performance analyses for essential components and subsystems are also provided. AEOSS has the feature permitting a user to enter known values of these parameters, totally and partially, at all levels. All information is of vital importance to project managers of subsystems or a spacecraft system. AEOSS is a specially tailored software coded from the relational database program of the Acius; 4th Dimension with a Macintosh version. Because of the licensing agreement, two versions of the AEOSS documents were prepared. This version AEOSS Design Guide, is for users to exploit the full capacity of the 4th Dimension. It is for a user who wants to alter or expand the program structures, the program statements, and the program procedures. The user has to possess a 4th Dimension first.

Estimating the cost-per-result of a national reflexed Cryptococcal antigenaemia screening program: Forecasting the impact of potential HIV guideline changes and treatment goals.

PubMed

Cassim, Naseem; Coetzee, Lindi Marie; Schnippel, Kathryn; Glencross, Deborah Kim

2017-01-01

During 2016, the National Health Laboratory Service (NHLS) introduced laboratory-based reflexed Cryptococcal antigen (CrAg) screening to detect early Cryptococcal disease in immunosuppressed HIV+ patients with a confirmed CD4 count of 100 cells/μl or less. The aim of this study was to assess cost-per-result of a national screening program across different tiers of laboratory service, with variable daily CrAg test volumes. The impact of potential ART treatment guideline and treatment target changes on CrAg volumes, platform choice and laboratory workflow are considered. CD4 data (with counts < = 100 cells/μl) from the fiscal year 2015/16 were extracted from the NHLS Corporate Date Warehouse and used to project anticipated daily CrAg testing volumes with appropriately-matched CrAg testing platforms allocated at each of 52 NHLS CD4 laboratories. A cost-per-result was calculated for four scenarios, including the existing service status quo (Scenario-I), and three other settings (as Scenarios II-IV) which were based on information from recent antiretroviral (ART) guidelines, District Health Information System (DHIS) data and UNAIDS 90/90/90 HIV/AIDS treatment targets. Scenario-II forecast CD4 testing offered only to new ART initiates recorded at DHIS. Scenario-III projected all patients notified as HIV+, but not yet on ART (recorded at DHIS) and Scenario-IV forecast CrAg screening in 90% of estimated HIV+ patients across South Africa (also DHIS). Stata was used to assess daily CrAg volumes at the 5th, 10th, 25th, 50th, 75th, 90th and 95th percentiles across 52 CD4-laboratories. Daily volumes were used to determine technical effort/ operator staff costs (% full time equivalent) and cost-per-result for all scenarios. Daily volumes ranged between 3 and 64 samples for Scenario-I at the 5th and 95th percentile. Similarly, daily volumes ranges of 1-12, 2-45 and 5-100 CrAg-directed samples were noted for Scenario's II, III and IV respectively. A cut-off of 30 CrAg tests per day defined use of either LFA or EIA platform. LFA cost-per-result ranged from $8.24 to $5.44 and EIA cost-per-result between $5.58 and $4.88 across the range of test volumes. The technical effort across scenarios ranged from 3.2-27.6% depending on test volumes and platform used. The study reported the impact of programmatic testing requirements on varying CrAg test volumes that subsequently influenced choice of testing platform, laboratory workflow and cost-per-result. A novel percentiles approach is described that enables an overview of the cost-per-result across a national program. This approach facilitates cross-subsidisation of more expensive lower volume sites with cost-efficient, more centralized higher volume laboratories, mitigating against the risk of costing tests at a single site.

Determination of trace level thorium and uranium in high purity gadolinium sulfate using ICP-MS with solid-phase chromatographic extraction resins

NASA Astrophysics Data System (ADS)

Ito, S.; Takaku, Y.; Ikeda, M.; Kishimoto, Y.

2018-01-01

The Super Kamiokand-Gadolinium (SK-Gd) project is the upgrade of the Super-Kamiokande (SK) detector in order to discover Supernova Relic Neutrinos (SRNs) by loading 0.2% of Gd2(SO4)3 into a 50 kton of the SK water tank. In order to continue solar neutrino measurement with low energy threshold at ˜3.5 MeV, main radioactive contamination, U and Th in Gd2(SO4)3, should be purified before loading. We developed solid-phase extraction technique to measure low concentration of U and Th in Gd2(SO4)3 by ICP-MS. The extraction technique and current status will be presented.

Joint projections of US East Coast sea level and storm surge

NASA Astrophysics Data System (ADS)

Little, Christopher M.; Horton, Radley M.; Kopp, Robert E.; Oppenheimer, Michael; Vecchi, Gabriel A.; Villarini, Gabriele

2015-12-01

Future coastal flood risk will be strongly influenced by sea-level rise (SLR) and changes in the frequency and intensity of tropical cyclones. These two factors are generally considered independently. Here, we assess twenty-first century changes in the coastal hazard for the US East Coast using a flood index (FI) that accounts for changes in flood duration and magnitude driven by SLR and changes in power dissipation index (PDI, an integrated measure of tropical cyclone intensity, frequency and duration). Sea-level rise and PDI are derived from representative concentration pathway (RCP) simulations of 15 atmosphere-ocean general circulation models (AOGCMs). By 2080-2099, projected changes in the FI relative to 1986-2005 are substantial and positively skewed: a 10th-90th percentile range 4-75 times higher for RCP 2.6 and 35-350 times higher for RCP 8.5. High-end FI projections are driven by three AOGCMs that project the largest increases in SLR, PDI and upper ocean temperatures. Changes in PDI are particularly influential if their intra-model correlation with SLR is included, increasing the RCP 8.5 90th percentile FI by a further 25%. Sea-level rise from other, possibly correlated, climate processes (for example, ice sheet and glacier mass changes) will further increase coastal flood risk and should be accounted for in comprehensive assessments.

Joint Projections of US East Coast Sea Level and Storm Surge

NASA Technical Reports Server (NTRS)

Little, Christopher M.; Horton, Radley M.; Kopp, Robert E.; Oppenheimer, Michael; Vecchi, Gabriel A.; Villarini, Gabriele

2015-01-01

Future coastal flood risk will be strongly influenced by sea-level rise (SLR) and changes in the frequency and intensity of tropical cyclones. These two factors are generally considered independently. Here, we assess twenty-first century changes in the coastal hazard for the US East Coast using a flood index (FI) that accounts for changes in flood duration and magnitude driven by SLR and changes in power dissipation index (PDI, an integrated measure of tropical cyclone intensity, frequency and duration). Sea-level rise and PDI are derived from representative concentration pathway (RCP) simulations of 15 atmosphere- ocean general circulation models (AOGCMs). By 2080-2099, projected changes in the FI relative to 1986-2005 are substantial and positively skewed: a 10th-90th percentile range 4-75 times higher for RCP 2.6 and 35-350 times higher for RCP 8.5. High-end Fl projections are driven by three AOGCMs that project the largest increases in SLR, PDI and upper ocean temperatures. Changes in PDI are particularly influential if their intra-model correlation with SLR is included, increasing the RCP 8.5 90th percentile FI by a further 25%. Sea-level rise from other, possibly correlated, climate processes (for example, ice sheet and glacier mass changes) will further increase coastal flood risk and should be accounted for in comprehensive assessments.

Evaluation of the Project Studies in Social Studies Course of Secondary Schools in Turkey

ERIC Educational Resources Information Center

Ibret, B. Unal; Recepoglu, Ergun; Karasu, Emine; Recepoglu, Serpil

2013-01-01

The aim of this study is to evaluate project studies in the 6th and 7th grades social studies courses of secondary schools according to opinions of students. This study is a descriptive research in the survey model. The sample is 880 students selected from 6th and 7th grades of 22 secondary schools randomly in central province of Kastamonu. As a…

The Chancellor's Model School Project (CMSP)

NASA Technical Reports Server (NTRS)

Lopez, Gil

1999-01-01

What does it take to create and implement a 7th to 8th grade middle school program where the great majority of students achieve at high academic levels regardless of their previous elementary school backgrounds? This was the major question that guided the research and development of a 7-year long project effort entitled the Chancellor's Model School Project (CMSP) from September 1991 to August 1998. The CMSP effort conducted largely in two New York City public schools was aimed at creating and testing a prototype 7th and 8th grade model program that was organized and test-implemented in two distinct project phases: Phase I of the CMSP effort was conducted from 1991 to 1995 as a 7th to 8th grade extension of an existing K-6 elementary school, and Phase II was conducted from 1995 to 1998 as a 7th to 8th grade middle school program that became an integral part of a newly established 7-12th grade high school. In Phase I, the CMSP demonstrated that with a highly structured curriculum coupled with strong academic support and increased learning time, students participating in the CMSP were able to develop a strong foundation for rigorous high school coursework within the space of 2 years (at the 7th and 8th grades). Mathematics and Reading test score data during Phase I of the project, clearly indicated that significant academic gains were obtained by almost all students -- at both the high and low ends of the spectrum -- regardless of their previous academic performance in the K-6 elementary school experience. The CMSP effort expanded in Phase II to include a fully operating 7-12 high school model. Achievement gains at the 7th and 8th grade levels in Phase II were tempered by the fact that incoming 7th grade students' academic background at the CMSP High School was significantly lower than students participating in Phase 1. Student performance in Phase II was also affected by the broadening of the CMSP effort from a 7-8th grade program to a fully functioning 7-12 high school which as a consequence lessened the focus and structure available to the 7-8th grade students and teachers -- as compared to Phase I. Nevertheless, the CMSP does represent a unique curriculum model for 7th and 8th grade students in urban middle schools. Experience in both Phase I and Phase II of the project allowed the CMSP to be developed and tested along the broad range of parameters and characteristics that embody an operating public school in an urban environment.

Dorsally exophytic glioblastoma arising from the medulla oblongata in an adult presenting as 4th ventricular mass.

PubMed

Das, Kuntal Kanti; Bettaswamy, Guru Prasad; Mehrotra, Anant; Jaiswal, Sushila; Jaiswal, Awadhesh Kumar; Behari, Sanjay

2017-01-01

Brainstem gliomas are relatively rare in adults (<2% of all gliomas). Exophytic gliomas are focal brainstem lesions, which project into the 4 th ventricle or cerebellopontine angles. These exophytic lesions are usually of low-grade histology (pilocytic astrocytoma or ganglioglioma) and have a relatively better outcome compared with brainstem gliomas as a whole. Glioblastoma is the commonest primary glial cell neoplasm and mostly occurs in the supratentorial compartment. It is rather uncommon in the brainstem and seldom has been described as having an exophytic growth pattern. Here we describe an exophytic brainstem glioblastoma arising from the medulla oblongata in a 55-year-old lady who presented with a 4 th ventricular mass, and present a brief review of the literature. Till now, six cases of glioblastoma arising from the medulla oblongata have been reported. So, ours is the seventh such report. To the best of our knowledge, it also happens to be the sixth reported case of dorsally exophytic brainstem glioblastoma till date.

Determination of neutron capture cross sections of 232Th at 14.1 MeV and 14.8 MeV using the neutron activation method

NASA Astrophysics Data System (ADS)

Lan, Chang-Lin; Zhang, Yi; Lv, Tao; Xie, Bao-Lin; Peng, Meng; Yao, Ze-En; Chen, Jin-Gen; Kong, Xiang-Zhong

2017-04-01

The 232Th(n, γ)233Th neutron capture reaction cross sections were measured at average neutron energies of 14.1 MeV and 14.8 MeV using the activation method. The neutron flux was determined using the monitor reaction 27Al(n,α)24Na. The induced gamma-ray activities were measured using a low background gamma ray spectrometer equipped with a high resolution HPGe detector. The experimentally determined cross sections were compared with the data in the literature, and the evaluated data of ENDF/B-VII.1, JENDL-4.0u+, and CENDL-3.1. The excitation functions of the 232Th(n,γ)233Th reaction were also calculated theoretically using the TALYS1.6 computer code. Supported by Chinese TMSR Strategic Pioneer Science and Technology Project-The Th-U Fuel Physics Term (XDA02010100) and National Natural Science Foundation of China (11205076, 21327801)

Diagnostic strategies for urinary tract infections in French general practice.

PubMed

Kinouani, S; de Lary de Latour, H; Joseph, J-P; Letrilliart, L

2017-10-01

We aimed to describe the diagnostic management procedures for detection of urinary tract infections in general practice and their correlated factors. We analyzed data from the ECOGEN study on urinary tract infections, collected in France between November 2011 and April 2012. This national cross-sectional study was carried out in general practices. Data was coded according to the International Classification of Primary Care. A total of 340 consultations or home visits were held for urinary tract infections. The five most frequent diagnostic procedures were (in descending order) clinical examination (67.6%), urine cytobacteriological examination (UCBE) (47.9%), urine dipstick test (15.6%), blood test (8.5%), and imaging (6.5%). No urine dipstick test or UCBE was performed in 43% of cases. Factors correlated with diagnostic procedures were age and gender of patients, annual number of consultations held by family physicians, and duration of consultation. Family physicians did not comply with guidelines on diagnostic management for detection of urinary tract infections. We hypothesized that this non-compliance could be due to the family physicians' environment and characteristics, and to clinical practice guidelines. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

[Execution and quality of attention paid to medical doctoral theses at the faculty of medicine at the University of Würzburg as seen by the doctoral candidates in their 5th and 6th year of study].

PubMed

Diez, C; Arkenau, C; Meyer-Wentrup, F

2002-07-01

The significance of a doctoral thesis in medicine has been discussed controversially among medical students and faculty members. We examined in a brief but comprehensive study how medical students evaluate their research activities and whether or not alternative thesis models should be implemented. A questionnaire comprising 50 questions was evaluated from 160 5th and 6th year medical students at the University of Wuerzburg. Almost two-thirds of our interviewees started working on a thesis project at the beginning of the 4th year of study. 59 % of our participants reported to have neglected the regular study and 56 % said to have prolonged the regular study due to the work on a thesis. Despite considerable variation, the median time spent weekly on a thesis project was 10 hours, independent of where the students worked. The median grade of satisfaction during the whole thesis was rated at 6.5 as assessed on an analogous scale from 1-10 (very satisfied). The research results from 94 students contributed to 164 articles (already published or in press) and the results of 110 students were presented at scientific meetings. Only 50 % of our interviewees were pleased with their published output and the importance of student research activities for the overall German biomedical research was rated 4.4 as assessed on an analogous scale from 1-10 (very important). 70 % of our interviewees preferred defined research periods and 47 % would apply for dual-degree research programmes. The scientific significance of a MD thesis in comparison to a PhD thesis was rated at 2.1 on an analogous scale from 1-5 (5 = equally significant). The current German research model might be modified and defined research periods and dual-degree research programmes as a one possible alternative should be considered.

BIOMETHANE FOR TRANSPORTATION

EPA Science Inventory

During phase I of this project we designed and built two different small-scale biogas refineries. The first design used a caustic absorption system. Our initial results showed an increase in CH₄ (methane) content from 60.50 Mol% in the raw biogas to 93.62 Mol% in th...

The 19th Project Integration Meeting

NASA Technical Reports Server (NTRS)

Mcdonald, R. R.

1981-01-01

The Flat-Plate Solar Array Project is described. Project analysis and integration is discussed. Technology research in silicon material, large-area silicon sheet and environmental isolation; cell and module formation; engineering sciences, and module performance and failure analysis. It includes a report on, and copies of visual presentations made at, the 19th Project Integration Meeting held at Pasadena, California, on November 11, 1981.

Project CHECO Southeast Asia Report. Project RED HORSE

DTIC Science & Technology

1969-09-01

It 0,Il 1IC1I lll Examination of C’urrentI,,,,,,,,[ I prations IIR / IE IP𔃻 0 R IT - PROJECT RED HORSE 1 SEPTEMBER 1969 HQ PACAF Directorate...3 CHAPTER II RED HORSE ORGANIZATIONS IN SOUTHEAST ASIA .................. 5 Introduction...RED HORSE Combat Defense Teams....................... ...... 59 III. 555th CES (HR) Projects...................................... 62 IV. 820th CES

Proceedings of the 24th Project Integration Meeting

NASA Technical Reports Server (NTRS)

Tustin, D.

1984-01-01

Progress made by the Flat-Plate Solar Array Project is described. Reports on silicon sheet growth and characterization, silicon material, process development, high-efficiency cells, environmental isolation, engineering sciences, and reliability physics are presented along with copies of visual presentations made at the 24th Project Integration Meeting.

Project FIT: A School, Community and Social Marketing Intervention Improves Healthy Eating Among Low-Income Elementary School Children.

PubMed

Alaimo, Katherine; Carlson, Joseph J; Pfeiffer, Karin A; Eisenmann, Joey C; Paek, Hye-Jin; Betz, Heather H; Thompson, Tracy; Wen, Yalu; Norman, Gregory J

2015-08-01

Project FIT was a two-year multi-component nutrition and physical activity intervention delivered in ethnically-diverse low-income elementary schools in Grand Rapids, MI. This paper reports effects on children's nutrition outcomes and process evaluation of the school component. A quasi-experimental design was utilized. 3rd, 4th and 5th-grade students (Yr 1 baseline: N = 410; Yr 2 baseline: N = 405; age range: 7.5-12.6 years) were measured in the fall and spring over the two-year intervention. Ordinal logistic, mixed effect models and generalized estimating equations were fitted, and the robust standard errors were utilized. Primary outcomes favoring the intervention students were found regarding consumption of fruits, vegetables and whole grain bread during year 2. Process evaluation revealed that implementation of most intervention components increased during year 2. Project FIT resulted in small but beneficial effects on consumption of fruits, vegetables, and whole grain bread in ethnically diverse low-income elementary school children.

Effect of zinc impurity on silicon solar-cell efficiency

NASA Technical Reports Server (NTRS)

Sah, C.-T.; Chan, P. C. H.; Wang, C.-K.; Yamakawa, K. A.; Lutwack, R.; Sah, R. L.-Y.

1981-01-01

Zinc is a major residue impurity in the preparation of solar-grade silicon material by the zinc vapor reduction of silicon tetrachloride. This paper projects that in order to get a 17-percent AM1 cell efficiency for the Block IV module of the Low-Cost Solar Array Project, the concentration of the zinc recombination centers in the base region of silicon solar cells must be less than 4 x 10 to the 11th Zn/cu cm in the p-base n+/p/p+ cell and 7 x 10 to the 11th Zn/cu cm in the n-base p+/n/n+ cell for a base dopant impurity concentration of 5 x 10 to the 14 atoms/cu cm. If the base dopant impurity concentration is increased by a factor of 10 to 5 x 10 to the 15th atoms/cu cm, then the maximum allowable zinc concentration is increased by a factor of about two for a 17-percent AM1 efficiency. The thermal equilibrium electron and hole recombination and generation rates at the double-acceptor zinc centers are obtained from previous high-field measurements as well as new measurements at zero field described in this paper. These rates are used in the exact dc-circuit model to compute the projections.

An Ensemble Approach to Understanding the ENSO Response to Climate Change

NASA Astrophysics Data System (ADS)

Stevenson, S.; Capotondi, A.; Fasullo, J.; Otto-Bliesner, B. L.

2017-12-01

The dynamics of the El Nino/Southern Oscillation (ENSO) are known to be sensitive to changes in background climate conditions, as well as atmosphere/ocean feedbacks. However, the degree to which shifts in ENSO characteristics can be robustly attributed to external climate forcings remains unknown. Efforts to assess these changes in a multi-model framework are subject to uncertainties due to both differing model physics and internal ENSO variability. New community ensembles created at the National Center for Atmospheric Research and the NOAA Geophysical Fluid Dynamics Laboratory are ideally suited to addressing this problem, providing many realizations of the climate of the 850-2100 period with a combination of both natural and anthropogenic climate forcing factors. Here we analyze the impacts of external forcing on El Nino and La Nina evolution using four sets of simulations: the CESM Last Millennium Ensemble (CESM-LME), which covers the 850-2005 period and provides long-term context for forced responses; the Large Ensemble (CESM-LE), which includes 20th century and 21st century (RCP8.5) projections; the Medium Ensemble (CESM-ME), which is composed of 21st century RCP4.5 projections; and a large ensemble with the GFDL ESM2M, which includes 20th century and RCP8.5 projections. In the CESM, ENSO variance increases slightly over the 20th century in all ensembles, with the effects becoming much larger during the 21st. The slower increase in variance over the 20th century is shown to arise from compensating influences from greenhouse gas (GHG) and anthropogenic aerosol emissions, which give way to GHG-dominated effects by 2100. However, the 21st century variance increase is not robust: CESM and the ESM2M differ drastically in their ENSO projections. The mechanisms for these inter-model differences are discussed, as are the implications for the design of future multi-model ENSO projection experiments.

BMI at Age 17 Years and Diabetes Mortality in Midlife: A Nationwide Cohort of 2.3 Million Adolescents.

PubMed

Twig, Gilad; Tirosh, Amir; Leiba, Adi; Levine, Hagai; Ben-Ami Shor, Dana; Derazne, Estela; Haklai, Ziona; Goldberger, Nehama; Kasher-Meron, Michal; Yifrach, Dror; Gerstein, Hertzel C; Kark, Jeremy D

2016-11-01

The sequelae of increasing childhood obesity are of major concern. We assessed the association of BMI in late adolescence with diabetes mortality in midlife. The BMI values of 2,294,139 Israeli adolescents (age 17.4 ± 0.3 years), measured between 1967 and 2010, were grouped by U.S. Centers for Disease Control and Prevention age/sex percentiles and by ordinary BMI values. The outcome, obtained by linkage with official national records, was death attributed to diabetes mellitus (DM) as the underlying cause. Cox proportional hazards models were applied. During 42,297,007 person-years of follow-up (median, 18.4 years; range <1-44 years) there were 481 deaths from DM (mean age at death, 50.6 ± 6.6 years). There was a graded increase in DM mortality evident from the 25th to the 49th BMI percentile group onward and from a BMI of 20.0-22.4 kg/m 2 onward. Overweight (85th to 94th percentiles) and obesity (the 95th percentile or higher), compared with the 5th to 24th percentiles, were associated with hazard ratios (HRs) of 8.0 (95% CI 5.7-11.3) and 17.2 (11.9-24.8) for DM mortality, respectively, after adjusting for sex, age, birth year, height, and sociodemographic variables. The HR for the 50th through 74th percentiles was 1.6 (95% CI 1.1-2.3). Findings persisted in a series of sensitivity analyses. The estimated population-attributable fraction for DM mortality, 31.2% (95% CI 26.6-36.1%) for the 1967-1977 prevalence of overweight and obesity at age 17, rose to a projected 52.1% (95% CI 46.4-57.4%) for the 2012-2014 prevalence. Adolescent BMI, including values within the currently accepted "normal" range, strongly predicts DM mortality up to the seventh decade. The increasing prevalence of childhood and adolescent overweight and obesity points to a substantially increased future adult DM burden. © 2016 by the American Diabetes Association.

An Evaluation of CMIP5 Precipitation Variability for China Relative to Observations and CMIP3

NASA Astrophysics Data System (ADS)

Frauenfeld, O. W.; Chen, L.

2013-12-01

Precipitation represents an important link between the atmosphere, hydrosphere, and biosphere and is thus a key component of the climate system. As indicated by the Fourth Assessment Report (AR4) of the Intergovernmental Panel on Climate Change (IPCC), global surface air temperatures increased by 0.74°C during the 20th century, with further warming of 0.2°C/decade projected by the 2030s. Projected changes in precipitation, however, are much more variable, and exhibit more complex temporal and spatial patterns. This presentation focuses on precipitation variability based on 20 general circulation models (GCMs) participating in the fifth coupled model intercomparison project (CMIP5). Specifically, we focus on China and provide a comprehensive evaluation of the CMIP5 models compared to historical 20th century precipitation variability from two observational precipitation products: the University of East Anglia's Climatic Research Unit (CRU) time series (TS) dataset version 3.10, and the Global Precipitation Climatology Centre (GPCC) version 6. We also reassess the performance of the third CMIP (CMIP3) to quantify potential improvements in CMIP5 over the previous generation of GCMs. Finally, we provide 21st century precipitation projections for China based on three representative concentration pathways (RCP): RCP 8.5, 4.5, and 2.6. These future precipitation projections are presented in light of the observed 20th century biases in the models. We find that CMIP5 models are able to better reproduce the general spatial pattern of observed 20th century precipitation than CMIP3. However, for China as a whole, the annual precipitation magnitude is overestimated in CMIP5, more so than in CMIP3. This smaller overestimation in CMIP3 was primarily driven by a large underestimation of summer precipitation. Spatially, overestimated precipitation magnitudes are evident for most regions of China, especially along the eastern margin of the Tibetan Plateau. Over southeastern China during summer, the precipitation amounts are underestimated. The multidecadal precipitation variability in CMIP5 is muted relative to observations, but improved when compared to CMIP3. We also assess precipitation trends and correlations relative to observations, and again find better agreement for CMIP5 than for CMIP3. Both observations and models indicated precipitation increases over parts of northwestern China, and decreases over the Tibetan Plateau throughout the 20th century. However, for the southeastern and northern regions of China there is poor agreement in precipitation trends. Precipitation is projected to increase across all of China under all the three emission scenarios during the 21st century. The largest significant trend is evident for RCP 8.5, which projects a precipitation increase of 1.5 mm/year, resulting in a 16% increase in precipitation by the end of the century. The smallest increases are projected to occur under the RCP 2.6 scenario, resulting in only a +6% change by 2100. The regions of greatest precipitation increases are the Tibetan Plateau and eastern China during summer, suggesting a potential change in the monsoonal circulation in the future.

A dopaminergic projection to the rat mammillary nuclei demonstrated by retrograde transport of wheat germ agglutinin-horseradish peroxidase and tyrosine hydroxylase immunohistochemistry

NASA Technical Reports Server (NTRS)

Gonzalo-Ruiz, A.; Alonso, A.; Sanz, J. M.; Llinas, R. R.

1992-01-01

The presence and distribution of dopaminergic neurons and terminals in the hypothalamus of the rat were studied by tyrosine hydroxylase (TH) immunohistochemistry. Strongly labelled TH-immunoreactive neurons were seen in the dorsomedial hypothalamic nucleus, periventricular region, zona incerta, arcuate nucleus, and supramammillary nucleus. A few TH-positive neurons were also identified in the dorsal and ventral premammillary nucleus, as well as the lateral hypothalamic area. TH-immunoreactive fibres and terminals were unevenly distributed in the mammillary nuclei; small, weakly labelled terminals were scattered in the medial mammillary nucleus, while large, strongly labelled, varicose terminals were densely concentrated in the internal part of the lateral mammillary nucleus. A few dorsoventrally oriented TH-positive axon bundles were also identified in the lateral mammillary nucleus. A dopaminergic projection to the mammillary nuclei from the supramammillary nucleus and lateral hypothalamic area was identified by double labelling with retrograde transport of wheat germ agglutinin-horseradish peroxidase and TH-immunohistochemistry. The lateral mammillary nucleus receives a weak dopaminergic projection from the medial, and stronger projections from the lateral, caudal supramammillary nucleus. The double-labelled neurons in the lateral supramammillary nucleus appear to encapsulate the caudal end of the mammillary nuclei. The medial mammillary nucleus receives a very light dopaminergic projection from the caudal lateral hypothalamic area. These results suggest that the supramammillary nucleus is the principal source of the dopaminergic input to the mammillary nuclei, establishing a local TH-pathway in the mammillary complex. The supramammillary cell groups are able to modulate the limbic system through its dopaminergic input to the mammillary nuclei as well as through its extensive dopaminergic projection to the lateral septal nucleus.

76 FR 2948 - Notice of Final Federal Agency Actions on Proposed Highway in Minnesota

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-18

... the meaning of 23 U.S.C. 139(l)(1). The actions relate to a proposed highway project on TH 371 from... agency actions by issuing approvals for the following highway project in Minnesota: TH 371 from the... Crow Wing and Cass Counties. A Record of Decision (ROD) for the TH 371 corridor from Nisswa to Pine...

Possible Climate Change/Variability and Human Impacts, Vulnerability of African Drought Prone Regions, its Water Resources and Capacity Building

NASA Astrophysics Data System (ADS)

Gan, T. Y. Y.; Qin, X.; Ito, M.; Hülsmann, S.; Xixi, L.; Liong, S. Y.; Disse, M.; Koivusalo, H. J.

2017-12-01

This review article discusses the climate, water resources and historical droughts of Africa, drought indices, vulnerability, impact of global warming and landuse to drought-prone regions in West, Southern, and Greater Horn of Africa, which have suffered recurrent severe droughts in the past. Recent studies detected warming and drying trends in Africa since the mid-20th century. Based on the 4th Assessment Report of the Intergovernmental Panel of Climate Change, and that of the 5th Coupled Model Intercomparison Project (CMIP5), both northern and southern Africa are projected to experience drying such as decreasing precipitation, runoff and soil moisture in the 21st Century and could become more vulnerable to impact of droughts. The daily maximum temperature is projected to increase up to 8oC (RCP8.5 of CMIP5), precipitation indices such as total wet day precipitation (PRCPTOT) and heavy precipitation days (R10mm) could decrease, while warm spell duration (WSDI) and consecutive dry days (CDD) could increase. Uncertainties of the above long-term projections, teleconnections to climate anomalies such as ENSO and Madden Julian Oscillation which could also affect water resources of Africa, and capacity building in terms of physical infrastructure and non-structural solutions, are also discussed. Given traditional climate and hydrologic data observed in Africa are generally limited, satellite data should also be exploited to fill in the data gap for Africa in future.

Apollo-Soyuz test project: Composite of MSFC final science report

NASA Technical Reports Server (NTRS)

1977-01-01

Experimental procedures of nine experiments conducted during the Apollo-Soyuz Test Project mission from July 15th to July 24th, 1975 are presented. Conclusions and recommendations based on these experiments are given.

The 50(th) Anniversary IMIA History of Medical Informatics Project.

PubMed

Kulikowski, Casimir A

2014-02-01

At the meeting of the IMIA Board in 2009 in Hiroshima, it approved an IMIA 50th Anniversary History Project to produce a historical volume and other materials to commemorate the anniversary of the foundation of the predecessor of IMIA-the IFIP-TC4 in 1967. A Taskforce was organized under the direction of Casimir Kulikowski, then the VP for Services of IMIA, and since that time it has met regularly to plan and implement the 50th Anniversary History of IMIA as an edited volume, and as material available online on a Media Presentation Database. The IMIA Taskforce is gathering IMIA-related archival materials, currently accessible through a prototype media repository at Rutgers University in order to help those contributing to the book or writing their own recollections and histories. The materials will support a chronicle of the development and evolution of IMIA, its contributors, its sponsored events and publications, educational and other professional activities. During 2013 Workshops were held at the Prague EFMI-STC meeting in April and at the MEDINFO 2013 Congress in Copenhagen in August.

New European Training Network to Improve Young Scientists' Capabilities in Computational Wave Propagation

NASA Astrophysics Data System (ADS)

Igel, Heiner

2004-07-01

The European Commission recently funded a Marie-Curie Research Training Network (MCRTN) in the field of computational seismology within the 6th Framework Program. SPICE (Seismic wave Propagation and Imaging in Complex media: a European network) is coordinated by the computational seismology group of the Ludwig-Maximilians-Universität in Munich linking 14 European research institutions in total. The 4-year project will provide funding for 14 Ph.D. students (3-year projects) and 14 postdoctoral positions (2-year projects) within the various fields of computational seismology. These positions have been advertised and are currently being filled.

Opportunity Surroundings on 3,000th Sol, Vertical Projection

NASA Image and Video Library

2012-09-07

This 360-degree vertical projection was assembled from images taken by the navigation camera on NASA Mars Exporation Rover Opportunity shows terrain surrounding the position where the rover spent its 3,000th Martian day.

Opportunity Surroundings on 3,000th Sol, Polar Projection

NASA Image and Video Library

2012-09-07

This 360-degree polar projection was assembled from images taken by the navigation camera on NASA Mars Exporation Rover Opportunity shows terrain surrounding the position where the rover spent its 3,000th Martian day.

Investigation and design of a Project Management Decision Support System for the 4950th Test Wing.

DTIC Science & Technology

1986-03-01

all decision makers is the need for memory aids (reports, hand written notes, mental memory joggers, etc.). 4. Even in similar decision making ... memories to synthesize a decision- making process based on their individual styles, skills, and knowledge (Sprague, 1982: 106). Control mechanisms...representations shown in Figures 4.9 and 4.10 provide a means to this objective. By enabling a manager to make and record reasonable changes to

Nutrition in Africa.

PubMed

Murray-lee, M

1989-07-01

Village women have adopted techniques set down by UNICEF in achieving higher food production and, ultimately, self sufficiency. Women's cooperatives integrate kitchen gardening and irrigated agriculture in an effort to combat the complex nutritional problems in Africa. Projects also offered training in a variety of areas including management of plots, labor-saving technology--diesel-driven grinding mills, rice husking, machines, wells with hand pumps, motor pumps for irrigation, all geared towards women benefitting themselves by growing their own food and furthering their children's health and development. Projects such as the one in Senegal were undertaken in other regions of Africa, like the Sahel and the Wadis--low-lying areas. From these projects, aid agencies and governments have suggested a number of recommendations in seeking a solution to Africa's nutritional problems. 1st, a balance between production of cash crops and food for consumption is called for. 2nd, research is necessary to improve the quality of locally grown food as much as livestock. 3rd, governments should extend surface area cultivation, 4th, more research on the advantage of indigenous food plants, 5th, women should be in on all levels of decision making in food production, 6th, governments should increase women farmer's efficiency, and further women's access to land and credit and 7th, women should be provided with increased educational opportunities. Nutrition in developing countries cannot be viewed as an isolated phenomenon--solutions to nutritional development should include all aspects of the problem including health and nutrition education, growth monitoring, water supply, literacy, technological know-how, and agricultural and plant and soil conservation.

The Hospital Microbiome Project: Meeting Report for the 1st Hospital Microbiome Project Workshop on sampling design and building science measurements, Chicago, USA, June 7th-8th 2012

PubMed Central

Smith, Daniel; Alverdy, John; An, Gary; Coleman, Maureen; Garcia-Houchins, Sylvia; Green, Jessica; Keegan, Kevin; Kelley, Scott T.; Kirkup, Benjamin C.; Kociolek, Larry; Levin, Hal; Landon, Emily; Olsiewski, Paula; Knight, Rob; Siegel, Jeffrey; Weber, Stephen; Gilbert, Jack

2013-01-01

This report details the outcome of the 1st Hospital Microbiome Project workshop held on June 7th-8th, 2012 at the University of Chicago, USA. The workshop was arranged to determine the most appropriate sampling strategy and approach to building science measurement to characterize the development of a microbial community within a new hospital pavilion being built at the University of Chicago Medical Center. The workshop made several recommendations and led to the development of a full proposal to the Alfred P. Sloan Foundation as well as to the creation of the Hospital Microbiome Consortium. PMID:23961316

Size at birth by gestational age and hospital mortality in very preterm infants: results of the area-based ACTION project.

PubMed

Da Frè, M; Polo, A; Di Lallo, D; Piga, S; Gagliardi, L; Carnielli, V; Miniaci, S; Macagno, F; Ravà, L; Ferrante, P; Cuttini, M

2015-01-01

Size at birth is an important predictor of neonatal outcomes, but there are inconsistencies on the definitions and optimal cut-offs. The aim of this study is to compute birth size percentiles for Italian very preterm singleton infants and assess relationship with hospital mortality. Prospective area-based cohort study. All singleton Italian infants with gestational age 22-31 weeks admitted to neonatal care in 6 Italian regions (Friuli Venezia-Giulia, Lombardia, Marche, Tuscany, Lazio and Calabria) (n. 1605). Hospital mortality. Anthropometric reference charts were derived, separately for males and females, using the lambda (λ) mu (μ) and sigma (σ) method (LMS). Logistic regression analysis was used to estimate mortality rates by gestational age and birth weight centile class, adjusting for sex, congenital anomalies and region. At any gestational age, mortality decreased as birth weight centile increased, with lowest values observed between the 50th and the 89th centiles interval. Using the 75th-89th centile class as reference, adjusted mortality odds ratios were 7.94 (95% CI 4.18-15.08) below 10th centile; 3.04 (95% CI 1.63-5.65) between the 10th and 24th; 1.96 (95% CI 1.07-3.62) between the 25th and the 49th; 1.25 (95% CI 0.68-2.30) between the 50(h) and the 74th; and 2.07 (95% CI 1.01-4.25) at the 90th and above. Compared to the reference, we found significantly increasing adjusted risk of death up to the 49th centile, challenging the usual 10th centile criterion as risk indicator. Continuous measures such as the birthweight z-score may be more appropriate to explore the relationship between growth retardation and adverse perinatal outcomes. Copyright © 2014 Elsevier Ltd. All rights reserved.

CRL/Brandeis: The DIDEROT System

DTIC Science & Technology

1993-01-01

system has already been evaluated in the 4th Mes- sage Understanding Conference (MUC-4) where it was required to extract information from 200 texts on...Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that... information extraction system built at CRL and Brandeis University over the past two years. It was produced as part of our efforts in the Tipster project

Radioactive ion beams produced by neutron-induced fission at ISOLDE

NASA Astrophysics Data System (ADS)

Catherall, R.; Lettry, J.; Gilardoni, S.; Köster, U.; Isolde Collaboration

2003-05-01

The production rates of neutron-rich fission products for the next-generation radioactive beam facility EURISOL [EU-RTD Project EURISOL (HPRI-CT-1999-50001)] are mainly limited by the maximum amount of power deposited by protons in the target. An alternative approach is to use neutron beams to induce fission in actinide targets. This has the advantage of reducing: the energy deposited by the proton beam in the target; contamination from neutron-deficient isobars that would be produced by spallation; and mechanical stress on the target. At ISOLDE CERN [E. Kugler, Hyperfine Interact. 129 (2000) 23], tests have been made on standard ISOLDE actinide targets using fast-neutron bunches produced by bombarding thick, high- Z metal converters with 1 and 1.4 GeV proton pulses. This paper reviews the first applications of converters used at ISOLDE. It highlights the different geometries and the techniques used to compare fission yields produced by the proton beam directly on the target with neutron-induced fission. Results from the six targets already tested, namely UC 2/graphite and ThO 2 targets with tungsten and tantalum converters, are presented. To gain further knowledge for the design of a dedicated target as required by the TARGISOL project [EU-RTD Project TARGISOL (HPRI-CT-2001-50033)], the results are compared to simulations, using the MARS [N.V. Mokhov, S.I. Striganov, A. Van Ginneken, S.G. Mashnik, A.J. Sierk, J. Ranft, MARS code developments, in: 4th Workshop on Simulating Accelerator Radiation Environments, SARE-4, Knoxville, USA, 14-15.9.1998, FERMILAB-PUB-98-379, nucl-th/9812038; N.V. Mokhov, The Mars Code System User's Guide, Fermilab-FN-628, 1995; N.V. Mokhov, MARS Code Developments, Benchmarking and Applications, Fermilab-Conf-00-066, 2000; O.E. Krivosheev, N.V. Mokhov, A New MARS and its Applications, Fermilab-Conf-98/43, 1998] code interfaced with MCNP [J.S. Hendrics, MCNP4C LANL Memo X-5; JSH-2000-3; J.F. Briemesteir (Ed.), MCNP - A General Montecarlo N-Particle Transport Code, Version 4C, LA-13709-M] libraries, of the neutron flux from the converters interacting with the actinide targets.

Radioactive ion beams produced by neutron-induced fission at ISOLDE

NASA Astrophysics Data System (ADS)

Isolde Collaboration; Catherall, R.; Lettry, J.; Gilardoni, S.; Köster, U.

2003-05-01

The production rates of neutron-rich fission products for the next-generation radioactive beam facility EURISOL [EU-RTD Project EURISOL (HPRI-CT-1999-50001)] are mainly limited by the maximum amount of power deposited by protons in the target. An alternative approach is to use neutron beams to induce fission in actinide targets. This has the advantage of reducing: the energy deposited by the proton beam in the target; contamination from neutron-deficient isobars that would be produced by spallation; and mechanical stress on the target. At ISOLDE CERN [E. Kugler, Hyperfine Interact. 129 (2000) 23], tests have been made on standard ISOLDE actinide targets using fast-neutron bunches produced by bombarding thick, high-/Z metal converters with 1 and 1.4 GeV proton pulses. This paper reviews the first applications of converters used at ISOLDE. It highlights the different geometries and the techniques used to compare fission yields produced by the proton beam directly on the target with neutron-induced fission. Results from the six targets already tested, namely UC2/graphite and ThO2 targets with tungsten and tantalum converters, are presented. To gain further knowledge for the design of a dedicated target as required by the TARGISOL project [EU-RTD Project TARGISOL (HPRI-CT-2001-50033)], the results are compared to simulations, using the MARS [N.V. Mokhov, S.I. Striganov, A. Van Ginneken, S.G. Mashnik, A.J. Sierk, J. Ranft, MARS code developments, in: 4th Workshop on Simulating Accelerator Radiation Environments, SARE-4, Knoxville, USA, 14-15.9.1998, FERMILAB-PUB-98-379, nucl-th/9812038; N.V. Mokhov, The Mars Code System User's Guide, Fermilab-FN-628, 1995; N.V. Mokhov, MARS Code Developments, Benchmarking and Applications, Fermilab-Conf-00-066, 2000; O.E. Krivosheev, N.V. Mokhov, A New MARS and its Applications, Fermilab-Conf-98/43, 1998] code interfaced with MCNP [J.S. Hendrics, MCNP4C LANL Memo X-5; JSH-2000-3; J.F. Briemesteir (Ed.), MCNP - A General Montecarlo N-Particle Transport Code, Version 4C, LA-13709-M] libraries, of the neutron flux from the converters interacting with the actinide targets.

A Harriet Tubman Celebration: Here's How We Do This Annual Mixed-Age Project.

ERIC Educational Resources Information Center

Mensher, Gail B.

1994-01-01

Describes one school's annual celebration of Harriet Tubman, 19th-century African-American heroine of the Underground Railroad. Children ages 4-11 engage in multisensory and cognitive learning activities designed to help them understand the rich traditions of early African Americans and the abolitionist movement to end slavery. Activities…

The Power of Four (the 4-Lab Study): ORD’s Integrated Disinfection By-Products Mixtures Research Project

EPA Science Inventory

Chemical disinfection of water, a major public health triumph of the 20th century, has resulted in dramatic decreases in morbidity and mortality from water-borne disease. The intended result of chemical disinfection of drinking water is reduction of microbial contamination; the u...

Preventing or Inventing? Understanding the Effects of Non-Prescriptive Design Briefs

ERIC Educational Resources Information Center

Oliveira, Sonja; Marco, Elena

2017-01-01

This paper discusses observations of an architecture and environmental engineering undergraduate design studio project assigned to 4th year students at a UK university. In the UK, most architecture courses are characterised by a high proportion of design studio teaching supported by varying amount of technical modules that include environmental…

BNL National Synchrotron Light Source activity report 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

During FY 1997 Brookhaven National Laboratory celebrated its 50th Anniversary and 50 years of outstanding achievement under the management of Associated Universities, Inc. This progress report is divided into the following sections: (1) introduction; (2) science highlights; (3) meetings and workshops; (4) operations; (5) projects; (6) organization; and (7) abstracts and publications.

HUPO BPP Workshop on Mouse Models for Neurodegeneration--Choosing the right models.

PubMed

Hamacher, Michael; Marcus, Katrin; Stephan, Christian; van Hall, Andre; Meyer, Helmut E

2005-09-01

The HUPO Brain Proteome Project met during the 4th Dutch Endo-Neuro-Psycho Meeting in Doorwerth, The Netherlands, on June 1, 2005, in order to discuss appropriate (mouse) models for neurodegenerative diseases as well as to conceptualise sophisticated proteomics analyses strategies. Here, the topics of the meeting are summarised.

Sesame Street Research: A 20th Anniversary Symposium (Princeton, New Jersey, November 4, 1989).

ERIC Educational Resources Information Center

Mann, Peter B., Ed.

A research agenda has been at the core of "Sesame Street" and other Children's Television Workshop (CTW) educational projects since inception. This collection of presentations, from a symposium honoring the twentieth anniversary of Sesame Street's debut on national television, addresses research's role in the series, describing how…

Recruiting Trends, 2010-2011. 40th Anniversary Edition

ERIC Educational Resources Information Center

Gardner, Phil

2011-01-01

This paper presents the recruiting trends for 2010-2011. This year's report is based on nearly 5,800 respondents, of which approximately 4,600 provided useable information, and 3,714 included complete hiring figures used for the projections. Despite the gloomy national labor market situation, the college segment of the market is poised to rebound…

78 FR 69928 - 35th Meeting: RTCA Special Committee 206, Aeronautical Information and Meteorological Data Link...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-21

...-Groups meetings SG4: SE2020 Eddy Dissipation Rate (EDR) Turbulence Project Plenary--SG3 Architecture Document FRAC Resolution 11 December Plenary--SG3 Architecture Document FRAC Resolution Sub-Group Meetings 12 December Plenary--SG3 Architecture Document FRAC Resolution Sub-Group Meetings 13 December Closing...

Ratio of Circulating IFNγ (+) "Th17 Cells" in Memory Th Cells Is Inversely Correlated with the Titer of Anti-CCP Antibodies in Early-Onset Rheumatoid Arthritis Patients Based on Flow Cytometry Methods of the Human Immunology Project.

PubMed

Kotake, Shigeru; Nanke, Yuki; Yago, Toru; Kawamoto, Manabu; Kobashigawa, Tsuyoshi; Yamanaka, Hisashi

2016-01-01

Rheumatoid arthritis (RA) is a systemic autoimmune disease with chronic joint inflammation characterized by activated T cells. IL-17 and Th17 cells play important roles in the pathogenesis of RA. Recently, plasticity in helper T cells has been demonstrated; Th17 cells can convert to Th1 cells. However, it remains to be elucidated whether this conversion occurs in the early phase of RA. Here, we validated the methods of the Human Immunology Project using only the cell-surface marker through measuring the actual expression of IL-17 and IFNγ. We also evaluated the expression of CD161 in human Th17 cells. We then tried to identify Th17 cells, IL-17(+)Th17 cells, and IFNγ (+)Th17 cells in the peripheral blood of early-onset RA patients using the standardized method of the Human Immunology Project. Our findings validated the method and the expression of CD161. The ratio of IFNγ (+)Th17 cells in memory T cells was inversely correlated to the titers of anti-CCP antibodies in the early-onset RA patients. These findings suggest that Th17 cells play important roles in the early phase of RA and that anti-IL-17 antibodies should be administered to patients with early phase RA, especially those with high titers of CCP antibodies.

Ratio of Circulating IFNγ + “Th17 Cells” in Memory Th Cells Is Inversely Correlated with the Titer of Anti-CCP Antibodies in Early-Onset Rheumatoid Arthritis Patients Based on Flow Cytometry Methods of the Human Immunology Project

PubMed Central

Kotake, Shigeru; Nanke, Yuki; Yago, Toru; Kawamoto, Manabu; Kobashigawa, Tsuyoshi; Yamanaka, Hisashi

2016-01-01

Rheumatoid arthritis (RA) is a systemic autoimmune disease with chronic joint inflammation characterized by activated T cells. IL-17 and Th17 cells play important roles in the pathogenesis of RA. Recently, plasticity in helper T cells has been demonstrated; Th17 cells can convert to Th1 cells. However, it remains to be elucidated whether this conversion occurs in the early phase of RA. Here, we validated the methods of the Human Immunology Project using only the cell-surface marker through measuring the actual expression of IL-17 and IFNγ. We also evaluated the expression of CD161 in human Th17 cells. We then tried to identify Th17 cells, IL-17+Th17 cells, and IFNγ +Th17 cells in the peripheral blood of early-onset RA patients using the standardized method of the Human Immunology Project. Our findings validated the method and the expression of CD161. The ratio of IFNγ +Th17 cells in memory T cells was inversely correlated to the titers of anti-CCP antibodies in the early-onset RA patients. These findings suggest that Th17 cells play important roles in the early phase of RA and that anti-IL-17 antibodies should be administered to patients with early phase RA, especially those with high titers of CCP antibodies. PMID:27294146

Fate vs choice: the immune system reloaded.

PubMed

Murphy, Kenneth M

2005-01-01

Development can occur by either instructive or stochastic processes. My colleagues and I have studied the contributions of these processes to differentiation of naïve CD4+ T-cells to either a Th1 or Th2 phenotype. Our initial discovery that pathogens in our in vitro priming system led to the development of Th1 cells through the action of interleukin-12 was important evidence of a link between innate and adaptive immunity. Subsequent studies in our laboratory revealed an important role for GATA-3 autoactivation in Th2 development. Other interesting projects that have emerged as a result of our Th cell differentiation studies include understanding the role of the inhibitory immunoreceptor B- and T-lymphocyte attenuator in the immune response, as well as the role of the transcription factor ERM in both T-cells and spermatogenesis. We currently maintain our interests in the Th differentiation field by trying to understand the role of type 1 interferons in Th1 development and the role of alternate promoters for the GATA-3 gene, among other things, but are also actively embarking on studies related to the choice between divergent cell types during embryonic stem cell differentiation.

The Effect of Project Based Learning on the Statistical Literacy Levels of Student 8th Grade

ERIC Educational Resources Information Center

Koparan, Timur; Güven, Bülent

2014-01-01

This study examines the effect of project based learning on 8th grade students' statistical literacy levels. A performance test was developed for this aim. Quasi-experimental research model was used in this article. In this context, the statistics were taught with traditional method in the control group and it was taught using project based…

"Alien Health Game": An Embodied Exergame to Instruct in Nutrition and MyPlate.

PubMed

Johnson-Glenberg, Mina C; Hekler, Eric B

2013-12-01

A feasibility study was run on an immersive, embodied exergame ("Alien Health Game") designed to teach 4th-12th-grade students about nutrition and several U.S. Department of Agriculture MyPlate guidelines. This study assessed acceptability and limited efficacy. Students learned about the amount of nutrients and optimizers in common food items and practiced making rapid food choices while engaging in short cardiovascular activities. Nineteen 4th graders played a "mixed reality" game that included both digital components (projected graphics on the floor) and tangible, physical components (hand-held motion-tracking wands). Players made food choices and experienced immediate feedback on how each item affected the Alien avatar's alertness/health state. One member of the playing dyad had to run short distances to make the game work. The final level included a digital projection of the MyPlate icon, and each food item filled the appropriate quadrant dynamically. All students remained engaged with the game after approximately 1 hour of play. Significant learning gains were seen on a pretest and posttest that assessed nutrition knowledge (paired t18=4.13, P<0.001). In addition, significant learning gains were also seen in knowledge regarding MyPlate (paired t18=3.29, P<0.004). Results suggest preliminary feasibility via demonstrated acceptability and improved within-group content knowledge. Future research should explore improved measures of knowledge gains, alternative mechanisms for supporting the game mechanics to increase the scalability of the system (i.e., via Kinect(®) [Microsoft(®), Redmond, WA] sensors), and the formal evaluation of the system via a randomized controlled trial.

Live Storybook Outcomes of Pilot Multidisciplinary Elementary Earth Science Collaborative Project

NASA Astrophysics Data System (ADS)

Soeffing, C.; Pierson, R.

2017-12-01

Live Storybook Outcomes of pilot multidisciplinary elementary earth science collaborative project Anchoring phenomena leading to student led investigations are key to applying the NGSS standards in the classroom. This project employs the GLOBE elementary storybook, Discoveries at Willow Creek, as an inspiration and operational framework for a collaborative pilot project engaging 4th grade students in asking questions, collecting relevant data, and using analytical tools to document and understand natural phenomena. The Institute of Global Environmental Strategies (IGES), a GLOBE Partner, the Outdoor Campus, an informal educational outdoor learning facility managed by South Dakota Game, Fish and Parks, University of Sioux Falls, and All City Elementary, Sioux Falls are collaborating partners in this project. The Discoveries at Willow Creek storyline introduces young students to the scientific process, and models how they can apply science and engineering practices (SEPs) to discover and understand the Earth system in which they live. One innovation associated with this project is the formal engagement of elementary students in a global citizen science program (for all ages), GLOBE Observer, and engaging them in data collection using GLOBE Observer's Cloud and Mosquito Habitat Mapper apps. As modeled by the fictional students from Willow Creek, the 4th grade students will identify their 3 study sites at the Outdoor Campus, keep a journal, and record observations. The students will repeat their investigations at the Outdoor Campus to document and track change over time. Students will be introduced to "big data" in a manageable way, as they see their observations populate GLOBE's map-based data visualization and . Our research design recognizes the comfort and familiarity factor of literacy activities in the elementary classroom for students and teachers alike, and postulates that connecting a science education project to an engaging storybook text will contribute to a successful implementation and measurable learning outcomes. We will report on the Fall 2017 pilot metrics of success, along with a discussion of multi partner collaborations, project scale-up and sustainability.

Evaluation of Historical and Projected Surface Air Temperature Simulations over China in CMIP5

NASA Astrophysics Data System (ADS)

Chen, L.; Frauenfeld, O. W.

2013-12-01

Projections of future temperature in China are crucial for assessments of climate change and implementation of appropriate adaptation and mitigation strategies. With the upcoming Intergovernmental Panel on Climate Change (IPCC) 5th Assessment Report (AR5), the fifth phase of the Coupled Model Intercomparison Project (CMIP5) was developed for assessing the latest state-of-the-art climate models and their projections. In this study, monthly surface air temperature from 20 CMIP5 models and four experiments (historical, RCP 2.6, RCP 4.5, and RCP 8.5) were used to investigate the temperature variability over China during the 20th century, and future changes for the 21st century. Two observational datasets (CRU TS 3.1 and the global terrestrial air temperature dataset from the University of Delaware) were adopted to evaluate the performance of the CMIP5 multimodel ensemble average, the performance of individual models, as well as the possible improvements in CMIP5 relative to CMIP3. Results show that both CMIP3 and CMIP5 have cold biases over most parts of China. CMIP5 displays a slightly better agreement with the observations than CMIP3, but substantial cold biases still exist over the Tibetan Plateau, especially in the cold season. These biases are also characterized by the greatest discrepancies among the individual models, indicating the models' limitations over this mountainous region. Both CMIP3 and CMIP5 show poor agreement with observed 20th-century temperature trends such that the spatial and seasonal patterns of the trends are not captured in the multimodel ensemble averages. Comparing individual models we find that MPI-ESM-LR, CanESM2, MIROC-ESM, and CCSM4 exhibit better skill than the other models in this part of the world. Projections of future temperature suggest that there will be a gradual increase in annual surface air temperature in China during the 21st century at a rate of 0.60°C/decade and 0.27°C/decade under the RCP 8.5 and RCP 4.5 scenarios, respectively. RCP 2.6 shows the slowest warming at a rate of 0.10°C/decade for the whole 21st century, but temperature will increase until 2040, and then remain stable or even decrease slightly. Based on the three emission scenarios, annual temperatures are projected to rise by 1.7-5.7°C by the end of the 21st century, and the greatest warming will occur over northern China and the Tibetan Plateau.

ME 5620 Fracture Mechanics in Engineering Design. Case Study Project

DTIC Science & Technology

2011-04-03

14 UNCLASSIFIED References 1 . A First Course in the Finite Element Method, 4th edition, by D.L. Logan, Thomson Engineering, 2006. 2. Altair ...collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources...currently valid OMB control number. 1 . REPORT DATE 03 APR 2011 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Case Study

Evaluation of the INTERGROWTH-21st project newborn standard for use in Canada.

PubMed

Liu, Shiliang; Metcalfe, Amy; León, Juan Andrés; Sauve, Reg; Kramer, Michael S; Joseph, K S

2017-01-01

To evaluate the performance of the INTERGROWTH-21st Project newborn standard vis-a-vis the current Canadian birth weight-for-gestational age reference. All hospital-based singleton live births in Canada (excluding Quebec) between 2002 and 2012 with a gestational age between 33 and 42 weeks were included using information obtained from the Canadian Institute for Health Information. Small- and large-for gestational age centile categories of the INTERGROWTH standard and Canadian reference were contrasted in terms of frequency distributions and rates of composite neonatal morbidity/mortality. Among 2,753,817 singleton live births, 0.87% and 9.63% were <3rd centile and >97th centile, respectively, of the INTERGROWTH standard, while 2.27% and 3.55% were <3rd centile and >97th centile, respectively, of the Canadian reference. Infants <3rd centile and >97th centile had a composite neonatal morbidity/mortality rate of 46.4 and 12.9 per 1,000 live births, respectively, under the INTERGROWTH standard and 30.9 and 16.6 per 1,000 live births, respectively, under the Canadian reference. The INTERGROWTH standard <3rd centile and >97th centile categories had detection rates of 3.14% and 9.74%, respectively, for composite neonatal morbidity/ mortality compared with 5.48% and 4.60%, respectively for the Canadian reference. Similar patterns were evident in high- and low-risk subpopulations. The centile distribution of the INTERGROWTH newborn standard is left shifted compared with the Canadian reference, and this shift alters the frequencies and neonatal morbidity/mortality rates associated with specific centile categories. Further outcome-based research is required for defining abnormal growth categories before the INTERGROWTH newborn standard can be used.

EnviSAT ASAR Monitoring Of The Natural And Archaeological Landscape Of Nasca, Peru

NASA Astrophysics Data System (ADS)

Cigna, Francesca; Tapete, Deodato; Lasaponara, Rosa; Masini, Nicola

2013-12-01

We exploit the 4year-long archive of ENVISAT ASAR IS2 C-band imagery available through ESA Cat-1 project id.11073 over Nasca (Southern Peru), to reconstruct the temporal evolution of the Rio Grande drainage basin and its impacts on the natural and cultural heritage preserved within this region, well- known for the evidences of the ancient Paracas and Nasca Civilizations who flourished between the 4th century BC and the 6th century AD. Inferences about the recent changes of the cultural landscapes and the main landforms in 2003-2007 were retrieved based on SAR backscattering (σ0) time series. Ancient aqueduct systems (the so-called puquios) and the famous geoglyphs ('Nasca Lines') were detected, even at a medium-resolution scale provided by ENVISAT images.

Space Shuttle Projects

NASA Image and Video Library

1989-08-08

On August 8, 1989, the 4th mission dedicated to the Department of Defense (DOD), STS-28, lifted off from Kennedy Space Center’s (KSC) launch pad 39B. The five day mission included a crew of five: Richard N. (Dick) Richards, pilot; Brewster H. Shaw, commander; and mission specialists David C. Leestma, Mark N. Brown, and James C. (Jim) Adamson.

HIMALAYAN BORDER COUNTRIES PROJECT

DTIC Science & Technology

Nepali school children, and (2) an investigation of iconology on three important ecclesiastical architecture forms in Kathmandu Valley. Professor Gordon...study of political and social developments in Nagaland. Mr. Mahesh C. Regmi completed the 4th volume of his study of Land Tenure and Taxation in Nepal in the summer of 1967 and commenced research on economic history of Nepal.

Maximum speed limits. Volume 4, An implementation method for setting a speed limit based on the 85th percentile speed

DOT National Transportation Integrated Search

1970-10-01

This volume contains an explanation of a method for setting a speed limit which was developed as a part of the project conducted by the Institute for Research in Public Safety under Contract No. FH-11-7275, "A Study for the Selection of Maximum Speed...

Reviving the Turtle: Exploring the Use of Logo with Students with Mild Disabilities

ERIC Educational Resources Information Center

Ratcliff, Corbet C.; Anderson, Susan E.

2011-01-01

In this case study, a group of nine 4th grade children were introduced to the Logo programming language during three 90-minute sessions over a four-week period. They attended a private university-based laboratory school serving students with various learning disabilities. This project demonstrated that a classic version of Logo captured the…

Proceedings of the 26th Project Integration Meeting

NASA Technical Reports Server (NTRS)

1986-01-01

Progress made by the Flat-plate Solar Array (FSA) Project is described for the period July 1985 to April 1986. Included are reports on silicon sheet growth and characterization, silicon material, process development, high-efficienty cells, environmental isolation, engineering sciences, and reliability physics. Also included are technical and plenary presentations made at the 26th Project Integration Meeting (PIM) held on April 29 to 30 and May 1, 1986.

20th Annual Residence Hall Construction Report

ERIC Educational Resources Information Center

Agron, Joe

2009-01-01

Even in difficult economic times, colleges and universities continue to invest in residence hall construction projects as a way to attract new students and keep existing ones on campus. According to data from "American School & University"'s 20th annual Residence Hall Construction Report, the median new project completed in 2008 was…

Utilization of Concurrent Buffers to Facilitate Seamless Data Transition in Tactical Cellular Communications

DTIC Science & Technology

2015-09-01

INTENTIONALLY LEFT BLANK xiii LIST OF ACRONYMS AND ABBREVIATIONS 2G 2nd Generation 3G 3rd Generation 3GPP 3rd Generation Partnership Project 4G 4th...System (UMTS) is the standard that governs 3rd Generation ( 3G ) migration of Global Services for Mobile (GSM) networks. It defines packet-based...network may assist or mitigate. 14. SUBJECT TERMS IEEE, 802.21, Media Independent Handover, mobile , communications, cyber, tactical, buffer, cellular

The Office of the Future--Implications for Change in Education. Position Papers: Annual Business Education Invitational Forum (4th, Provo, Utah, 1977). Research and Service Project Number 4.

ERIC Educational Resources Information Center

Waters, Max L., Ed.

This publication contains six position papers presented by guest businessmen during the fourth annual Business Education Invitational Forum on the topic of implications of current change and technology in the environment in the office of the future. The article, The Office in the 1970's, describes the office as it is and as it is evolving, defines…

The association of maternal thyroid function with placental hemodynamics.

PubMed

Barjaktarovic, M; Korevaar, T I M; Chaker, L; Jaddoe, V W V; de Rijke, Y B; Visser, T J; Steegers, E A P; Peeters, R P

2017-03-01

What is the clinical association of maternal thyroid function with placental hemodynamic function? A higher free thyroxine (FT4) concentration in early pregnancy is associated with higher placental vascular resistance. Suboptimal placental function is associated with preeclampsia (which, in turn, further deteriorates placental hemodynamics and impairs the fetal blood supply), fetal growth restriction and premature delivery. Studies have suggested that thyroid hormone (TH) has a role in placental development through effects on trophoblast proliferation and invasion. This study was embedded in The Generation R cohort, a population-based prospective study from early fetal life onwards in Rotterdam, the Netherlands. In total, 7069 mothers with expected delivery date between April 2002 and January 2006 were enrolled during early pregnancy. Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) concentrations were measured during early pregnancy (median 13.4 weeks, 95% range 9.7-17.6 weeks). Placental function was assessed by Doppler ultrasound via measurement of arterial vascular resistance, i.e. umbilical artery pulsatility index (PI) and uterine artery resistance index (RI) (both measured twice, between 18-25th and after 25th gestational weeks) and the presence of uterine artery notching (once after the 25th gestational week) in 5184 pregnant women. FT4 was positively linearly associated with umbilical artery PI in the second and third trimesters as well as with uterine artery RI in the second trimester and the risk of uterine artery notching in the third trimester (P < 0.05 for all). The association of thyroid function with preeclampsia and birth weight was partially mediated through changes in placental function, with the percentages of mediated effects being 10.4% and 12.5%, respectively. A potential limitation is the availability of only a single time point for TH measurements and different numbers of missing placental ultrasound measurements for the adverse outcomes. A higher FT4 concentration in early pregnancy is associated with higher vascular resistance in the second and third trimesters in both the maternal and fetal placental compartment. These effects on placental function might explain the association of FT4 with adverse pregnancy outcomes, including preeclampsia and fetal growth restriction. This work was supported by a fellowship from ERAWEB, a project funded by the European Commission (to M.B.) and by clinical fellowship from The Netherlands Organization for Health Research and Development (ZonMw), Project 90700412 (to R.P.P.). The authors have no conflict of interest. N/A. © The Author 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

"Pathways to Excellence in Teaching and Learning." Proceedings from the Annual MCLCA Conference (4th, Evanston, Illinois, October 11-13, 1989).

ERIC Educational Resources Information Center

Eckermann, Carol A., Ed.

This report of a conference dedicated to the growth of professionalism within the field of learning assistance begins with a brief introduction reviewing the origins and objectives of the sponsoring association, followed by 10 representative papers. The papers have the following titles and authors: "The Classroom Research Project: Results at…

Early Education and the Exceptional Child. Proceedings of the Annual Montana Symposium (4th, Billings, Montana, April 27-29, 1983).

ERIC Educational Resources Information Center

Mason, Christine Y., Ed.

The proceedings of a 1983 symposium on early education and the exceptional child features 18 presentations of overall issues, cost effectiveness, special projects, social interaction, and curriculum and instructional issues. Works with the following titles and authors are included: "Education: A Look to the Future" (J. Tawney); "Movement from…

Measuring the Impact of a Supplemental Civic Education Program on Students' Civic Attitude and Efficacy Beliefs

ERIC Educational Resources Information Center

Piñgul, Ferdinand S.

2015-01-01

This study examines the impact of Project Citizen Philippines, an extra-classroom civic education program, on its 3rd and 4th year high school participants' civic attitude and efficacy beliefs. Three hundred forty three participants and 107 non-participants from various public high schools in the Philippines' National Capital Region were compared…

A generalized four-fifth law for compressible turbulence

NASA Astrophysics Data System (ADS)

Aluie, Hussein

2016-11-01

Kolmogorov's 4/5-th law is a celebrated exact result of incompressible turbulence, and is key to the formulation of his 1941 phenomenology. We will present its generalization to compressible turbulence. Partial support was provided by NSF Grant OCE-1259794, US Department of Energy (US DOE) Grant DE-SC0014318, and the LANL LDRD program through Project Number 20150568ER.

Are You Ready to Take the Plunge? Create an Amusement Park.

ERIC Educational Resources Information Center

Mueller, Andrea; Brown, Rod

2000-01-01

Describes an activity on charting 6th and 7th grade students' ideas about a potential science project. Summarizes a five week project on creating a new ride or redesigning existing rides in an amusement park, including research and sketches, final drawings, models of rides, and class presentations. (YDS)

Sarah J. Hale High School-Project SABER.

ERIC Educational Resources Information Center

Rosenblatt, Harold

Project SABER, which operated in Sarah J. Hale High School in South Brooklyn, New York, consisted of bilingual instructional and supportive services to 9th and 10th grade Spanish language students. Students received bilingual instruction in social studies, science, math, and Spanish. All the SABER students received English as a second language…

76 FR 61074 - Reports and Updates on Arctic Research Programs and Projects; Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-03

... UNITED STATES ARCTIC RESEARCH COMMISSION Reports and Updates on Arctic Research Programs and Projects; Meetings Notice is hereby given that the US Arctic Research Commission will hold its 96th meeting... about topics of interest related to research activities in the Arctic. 96th Meeting Schedule: Wed., Oct...

An Intensive Cultural Resource Survey for the Bank Stabilization Project: A Late 19th Century Stoneware Manufacturing Site, Bonaparte, Iowa.

DTIC Science & Technology

1983-11-01

in New England where this type of mass production got underway to any extent was Bennington , Vermont . The famous works there was the brain child of...4 2 Landform Regions of Iowa ...................... 7 3 Schematic of Van Buren County Geology ................. 7 4 Soils Within...Changes. In "Pleistocene and Recent Environments of the Central Great Plains," edited by W. Dort and J. Jones, University of Kansas, Department of Geology

French Interim MALE UAV Program

DTIC Science & Technology

2003-09-02

MINISTÈRE DE LA DÉFENSE June, 13th 2002 Lcl Monsterleet FAF Staff J. Caron EADS S&DE-ISR FRENCH INTERIM MALE UAV PROGRAM 4 INDUSTRIAL STATUS Report...2003 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE French Interim Male UAV Program 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) EADS

PREFACE: 7th International Conference on Cooling & Heating Technologies (ICCHT 2014)

NASA Astrophysics Data System (ADS)

2015-09-01

The Kyoto protocol has initiated a pledge from almost all developing and developed countries to be committed to reducing CO2 emissions. Development of new renewable energy technologies are also of interest in this conference. Greenhouse gases have contributed to global warming and other man-made disasters. Cooling and Heating communities also have responsibilities towards the commitment of reducing the greenhouse gas emissions. In addition, depleting natural resources also act as a threat to the Cooling and Heating industries, causing them to develop highly efficient equipment and innovative technologies. The 1st International Conference on Cooling & Heating Technologies was held in Hanoi Vietnam (Jan. 2005). Whereas the 2nd, 3rd, 4th and 5th ICCHT conferences were held in Dalian, China (Jul. 2006), Tokyo, Japan (Jul. 2007), Jinhae, Korea (Oct. 2008) and Bandung, Indonesia (Dec. 2010) respectively. The 6th International Conference on Cooling & Heating Technologies (ICCTH2012) was held in Xi'an in China on November 9-12, 2012. It is our pleasure to welcome you to the 7th International Conference on Cooling & Heating Technologies (ICCTH2014) on 4th - 6th November 2014 at the Grand Dorsett Subang Hotel, Subang Jaya, Selangor Darul Ehsan, Malaysia The Theme of the Conference is ''Sustainability and Innovation in Heating & Cooling Technologies''. The sub-themes are:- • CO2 Reduction and Low Carbon Technologies • HVAC System and Natural Ventilation • Energy & Alternative Energy • Computational Fluid Dynamics • Low Temperature & Refrigeration Engineering In conjunction with the Conference, an Exhibition will be organized as an integral part of the Conference. Project experiences, product solutions, new applications and state-of-the art information will be highlighted.

The Relationship between Academic Averages of Primary School Science and Technology Class and Test Sub-Test Scores of Placement Test of Science

ERIC Educational Resources Information Center

Guzeller, Cem Oktay

2012-01-01

In this research, the relationship between written exam scores of science and technology class of 6th, 7th, and 8th grades, project, participation in class activities and performance work, year-end academic success point averages and sub-test raw scores of LDT science of 6th, 7th and 8th grades. Academic success point averages were used as…

Creating a human brain proteome atlas--13th HUPO BPP Workshop March 30-31, 2010, Ochang, Korea.

PubMed

Gröttrup, Bernd; Stephan, Christian; Marcus, Katrin; Grinberg, Lea T; Wiltfang, Jens; Lee, Sang K; Kim, Young H; Meyer, Helmut E; Park, Young M

2011-07-01

The HUPO Brain Proteome Project (HUPO BPP) held its 13th workshop in Ochang from March 30th to 31st, 2010 prior to the Korean HUPO 10th Annual International Proteomics Conference. The principal aim of this project is to obtain a better understanding of neurodiseases and aging with the ultimate objective of discovering prognostic and diagnostic biomarkers, in addition to the development of novel diagnostic techniques and new medications. The attendees came together to discuss progress in the clinical neuroproteomics of human and to define the needs and guidelines required for more advanced proteomics approaches. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Examining the Influence of Technology and Project-Supported Thinking Journey on Achievement

ERIC Educational Resources Information Center

Baran, Medine; Maskan, Abdulkadir

2013-01-01

The purpose of this study was to investigate the influence of the technology and project-supported Thinking Journey on 11th grade high school students' achievements in the subject of electricity units. The participants were 68 high school 11th grade students from two different science classes. Control and experimental groups were selected at…

Corrigendum: Bounding sea level projections within the framework of the possibility theory Environ. Res. Lett. (2017 12 014012)

NASA Astrophysics Data System (ADS)

Le Cozannet, Gonéri; Manceau, Jean-Charles; Rohmer, Jeremy

2017-10-01

Figures 3 and 4 of the article ‘Bounding probabilistic sea-level projections within the framework of the possibility theory’ display a minimum value for sea level rise of 15 cm by 2100 with respect to the 1986-2005 mean for the RCP 8.5. The value of 15 cm is consistent with sea level rise rates dropping back to velocities observed during the 20th century according to recent studies, but not to the current sea level rise velocity of 3.4 mm yr-1, as incorrectly stated in the article. This error has no impact on the rest of the article, including its arguments and conclusions, but it is potentially confusing for scientists willing to reproduce the left side of figures 3 and 4. We apologise for any inconvenience caused.

Navistar eStar Vehicle Performance Evaluation – 4th Quarter 2013; Energy Efficiency & Renewable Energy (EERE), Vehicle Technologies Office (VTO)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2014-01-01

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Navistar will build and deploy all-electric medium-duty trucks. The trucks will be deployed in diverse climates across the country.

Navistar eStar Vehicle Performance Evaluation - 4th Quarter 2012; Energy Efficiency & Renewable Energy (EERE), Vehicle Technologies Office (VTO)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2013-05-01

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Navistar will build and deploy all-electric medium-duty trucks. The trucks will be deployed in diverse climates across the country.

Two Web-GIS Projects on Russian Historical Sources of the 15-19th Centuries

NASA Astrophysics Data System (ADS)

Frolov, Aleksei A.; Golubinskiy, Aleksei A.

2018-05-01

The paper describes an experience of online-publication of Russian archival materials by means of two web-GIS projects. The first project is devoted to publication of the collection of the earliest Russian cartographic drawings (mainly 2nd half of the 17th century), which cover a significant part of Russian territory, mainly the European part (http://rgada.info/geos2). Most of them have never been published and were not easily accessible for scholars and users due to poor physical condition. We tried to combine opportunities of geocoding of the picture with capacity to use an authentic image. The second project offers the results of localization of toponyms and land parcels from various documents (15-19th cc.) connected with one region of the Russian State called Bezhetsk Upland (http://rgada.info/bezheck/popup.html). These results were arranged in the set of layers which may be combined by the user.

Nanostructured Materials for Renewable Alternative Energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parsons, Gregory

2013-07-24

This project has been in effect from July 25 th, 2008 to July 24 th, 2013. It supported 19 graduate students and 6 post-doctoral students and resulted in 23 publications, 7 articles in preparation, 44 presentations, and many other outreach efforts. Two representative recent publications are appended to this report. The project brought in more than $750,000 in cost share from North Carolina State University. The project funds also supported the purchase and installation of approximately 667,000 in equipment supporting solar energy research.

Morphofunctional evidence for the involvement of hypothalamic dopaminergic and GABAergic neurons in the mechanisms of photoperiod-dependent prolactin release in the mink.

PubMed

Boissin-Agasse, L; Tappaz, M; Roch, G; Gril, C; Boissin, J

1991-06-01

This study was designed to examine possible relationships between the photoperiodic regulation of prolactin secretion and the activity of dopaminergic and GABAergic neurons projecting to the external layer of the median eminence. The study was carried out on the mink whose remarkable photosensitivity has been clearly demonstrated. The animals were reared in short (4L:20D) or long (20L:4D) photoperiods. The experiment began in November when day length is short (9.5 h). Dopaminergic and GABAergic neurons were studied using immunocytochemical methods allowing evaluation of the immunoreactivities of tyrosine hydroxylase (TH) and glutamate decarboxylase (GAD), which are respective markers of these neurons. The results were quantified by image analysis. The plasma prolactin level of animals maintained in 4L:20D decreased after 60 days and TH and GAD immunoreactivity were strongly stimulated. After 110 days, the prolactin concentration and TH and GAD immunoreactivity recovered their starting levels. In animals maintained in 20L:4D, the prolactin level was 3 times higher than at the beginning of the photoperiodic treatment but only dopaminergic neurons showed a change, i.e. a decrease in immunoreactivity. At the end of the experiment, prolactin secretion was no longer affected by the stimulatory effect of long-day treatment, and TH immunoreactivity remained low. These results confirm the generally accepted concept that dopaminergic neurons are potent PIF-producing components. GABAergic hypothalamic system appears to be implicated in photoperiodic PRL regulation, but this remains to be clearly demonstrated.

Combining Laboratory Experiments with Digital Tools to Do Scientific Inquiry

ERIC Educational Resources Information Center

Kluge, Anders

2014-01-01

This qualitative study investigates the gap between a lab experiment and theory of science. Two groups of 4 students in 2 different classes in 11th grade (15-16 years old) are followed as they process results and experiences from a lab experiment using a digital environment. The experiment is as a part of a larger project about genes and cells,…

Japan’s National Interests in Taiwan

DTIC Science & Technology

2013-06-01

to understand that, while Japan’s imperialistic actions throughout Asia and the Pacific from the late 19th century until the end of WWII are...1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202–4302, and to the Office of Management and Budget, Paperwork Reduction Project (0704...of U.S.–China–Japan Relations ...........................28  4.  The End of the “1955 System

Maximiser la communication famille-ecole: Quand les TIC font mouche = Maximizing Family-School Communication: When ICT Hits the Mark.

ERIC Educational Resources Information Center

Karsenti, Thierry; Garnier, Yves Daniel

2002-01-01

A pilot project that created a school Web site and e-mail service demonstrated the importance of information technology to Montreal (Quebec) 4th-grade students and their teachers. E-mail allowed teachers to have more efficient and less time-consuming communications with parents and allowed parents to more closely engage in their children's school…

Classification of Air Force Aviation Accidents: Mishap trends and Prevention

DTIC Science & Technology

2006-06-02

Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188), ,Wpshngrton. DC...Masters, Stone, Babcock, & Rypka, 1974; Moroze & Snow, 1999), and those specifically Mishap Trends & Prevention 4 addressing HFACS (Shappell... Moroze , M. L. & M. P. Snow (1999). Causes and remedies of controlled flight into terrain in military and civil aviation. 1 0 th International

TEACHING MACHINES AND PROGRAMMED LEARNING IN THE SOVIET BLOC--A SURVEY OF THE PUBLISHED LITERATURE, 1962-1963.

ERIC Educational Resources Information Center

Joint Publications Research Service, Washington, DC.

THIS REVIEW REPORTS THE STATE OF THE ART OF PROGRAMED INSTRUCTION IN THE SOVIET UNION. A NUMBER OF TEACHING MACHINES ARE DESCRIBED, AS ARE PROJECTED DEVELOPMENTS IN SOVIET PROGRAMED INSTRUCTION. IT IS EXPECTED THAT THE 4TH ALL-RUSSIAN CONFERENCE ON THE APPLICATION OF TECHNICAL DEVICES AND PROGRAMING IN EDUCATION (JAN. 1964) WILL PROVIDE FURTHER…

In Service Training of Head Start Teachers to Overcome Early Risks of Mathematics Failure: The Mathstaar Program

ERIC Educational Resources Information Center

Geist, Eugene A.; Geist, Kamile

2009-01-01

This action research project is designed as a music-based intervention to address and overcome some of the risk factors for low achievement in mathematics that research has linked to poverty level. The National Assessment of Educational Progress found that children who are eligible for school lunch programs in 4th grade score on average 13 points…

"The Three Pigs": Can They Blow Us into Critical Media Literacy Old School Style?

ERIC Educational Resources Information Center

Flores-Koulish, Stephanie A.; Smith-D'Arezzo, Wendy Marie

2016-01-01

In this article, the authors show how groups of 2nd- and 4th-grade students in an urban school district responded to a postmodern children's book, The "Three Pigs" by David Wiesner (2001). The students came to the project from basal-based direct instruction, and here they were offered a more constructivist opportunity to engage with a…

Cigarette Use in 6th Through 10th Grade: The Sarasota County Demonstration Project

ERIC Educational Resources Information Center

Zapata, Lauren B.; Forthofer, Melinda S.; Eaton, Danice K.; Brown, Kelli McCormack; Bryant, Carol A.; Reynolds, Sherri T.; McDermot, Robert J.

2004-01-01

Objectives: To identify factors associated with cigarette smoking in the 6 th -grade through 10 th -grade youth population of Sarasota County, Florida. Methods: A closed-ended, quantitative survey was completed by 2004 youth and used to extract population-specific data on the correlates of cigarette use. Results: A range of factors influence…

Commission 8: Astrometry

NASA Astrophysics Data System (ADS)

Evans, Dafydd Wyn; Zacharias, Norbert; Kumkova, Irina; Andrei, Alexandre; Brown, Anthony; Gouda, Naoteru; Popescu, Petre; Souchay, Jean; Unwin, Stephen; Zhu, Zi

2012-04-01

Gaia is continuing well with its development and construction and is expected to achieve parallax accuracies of about 10 to 300 μas for 6 to 20 mag. It is scheduled to launch in 2013. The ICRF2 was adopted by the IAU in 2009 as the new fundamental celestial reference frame. The UCAC project concluded with the publication of its 4th data release (all-sky, over 100 million stars). The JASMINE project will launch the Nano-JASMINE satellite in 2012 and continues with the development of its other satellites which will complement the Gaia project. The PPMXL (Heidelberg) and XPM (Ukraine) catalogues provide improved astrometric accuracies from new reductions of USNO-B (USNO-A) and 2MASS data. It is disappointing that the SIM project was cancelled during this triennium. It would have further complemented the above two satellite projects and would have gone even beyond Gaia in astrometric accuracy.

Probing the Influence of Acidity and Temperature to Th(IV) on Hydrolysis, Nucleation, and Structural Topology.

PubMed

Lin, Jian; Qie, Meiying; Zhang, Linjuan; Wang, Xiaomei; Lin, Yuejian; Liu, Wei; Bao, Hongliang; Wang, Jianqiang

2017-11-20

Systematic control of the molar ratio between thorium hydroxides and selenic acid and their reaction temperature under hydrothermal conditions results in four novel thorium-based selenate complexes, namely, [Th 8 O 4 (OH) 8 (SeO 4 ) 6 (H 2 O) 16 ]·(SeO 4 ) 2 ·13H 2 O (Th-1), [Th 8 O 4 (OH) 8 (SeO 4 ) 8 (H 2 O) 13 ]·7H 2 O (Th-2), Th(OH) 2 (SeO 4 )H 2 O (Th-3), and Th 3 (SeO 4 ) 6 (H 2 O) 6 ·2.5H 2 O (Th-4), as well as the thorium mixed selenite selenate compound Th(SeO 3 )(SeO 4 ) (Th-5). Smaller [H 2 SeO 4 ]/[Th(IV)] ratio or lower temperature give rise to the formation of octameric [Th 8 (μ 3 -O) 4 (μ 2 -OH) 8 ] 16+ cores in Th-1/Th-2 and infinite [Th(μ 2 -OH) 2 H 2 O] 2+ chains in Th-3, respectively. Increasing the [H 2 SeO 4 ]/[Th(IV)] ratio or elevating the temperature generates a microporous (11.3 Å voids) open-framework Th-4, a monomeric thorium species without oxo/hydroxyl ligands, and a three-dimensional thorium structure Th-5. Formation of these compounds suggests that variables including acidity and temperature play a critical role in the hydrolysis and oligomerization of Th IV ions. Increasing acidity limits the deprotonation of water molecules and formation of nucleophilic hydroxo/oxo-aquo Th species, and high temperature appears to suppress the olation/oxolation hydrolysis reactions, which in both ways limit the formation of the thorium oligomers.

Implementation of an ICT-Based Learning Environment in a Nutrition Health Project

ERIC Educational Resources Information Center

Raiha, Teija; Tossavainen, Kerttu; Enkenberg, Jorma; Turunen, Hannele

2012-01-01

Purpose: The purpose of this study was to investigate the views of school staff on a nutrition health project implemented via an ICT-based learning environment in a secondary school (7th to 9th grades). Design/methodology/approach: The study was a part of the wider European Network for Health Promoting Schools programme (ENHPS; since 2008, Schools…

CA 2025: The Strategic Design of Civil Affairs

DTIC Science & Technology

2015-06-01

NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA CAPSTONE PROJECT Approved for public release; distribution is unlimited CA 2025...Paperwork Reduction Project (0704-0188) Washington DC 20503. 1. AGENCY USE ONLY (Leave blank) 2. REPORT DATE June 2015 3. REPORT TYPE AND...Airborne) 96th CA BN(A) 96th Civil Affairs Battalion (Airborne) AAA American Anthropological Association AC active component ADM Army Design

Bilingual Language Arts Survival Training: Project BLAST, 1987-88. OREA Evaluation Report.

ERIC Educational Resources Information Center

Berney, Tomi D.; Alvarez, Rosalyn

Project Bilingual Language Arts Survival Training (BLAST) served 254 Spanish-speaking 9th- through 12th-graders at Walton High School in the Bronx in its fifth year of funding. The program's aim was to supplement the school's bilingual program by providing instruction in English as a Second Language (ESL), native language arts (NLA) and culture,…

Minimizing Bullying Behavior of Middle School Students through Behavioral Intervention and Instruction

ERIC Educational Resources Information Center

Drosopoulos, J. Dan; Heald, A. Zachariah; McCue, M. John

2008-01-01

This action research project report examined all forms of bullying behaviors and ways to reduce those behaviors. The project included 63 students from both a high school health class and a 6th and 7th grade middle school homeroom. The research was conducted from September 17, 2007 through December 14, 2007. In the specified locations, female to…

The Impact of Project-Based Learning on Minority Student Achievement: Implications for School Redesign

ERIC Educational Resources Information Center

Cervantes, Bernadine; Hemmer, Lynn; Kouzekanani, Kamiar

2015-01-01

Project-Based Learning (PBL) serves as an instructional approach to classroom teaching and learning that is designed to engage students in the investigation of real-world problems to create meaningful and relevant educational experiences. The causal-comparative study compared 7th and 8th students who had utilized the PBL with a comparison group in…

The Effect on the 8th Grade Students' Attitude towards Statistics of Project Based Learning

ERIC Educational Resources Information Center

Koparan, Timur; Güven, Bülent

2014-01-01

This study investigates the effect of the project based learning approach on 8th grade students' attitude towards statistics. With this aim, an attitude scale towards statistics was developed. Quasi-experimental research model was used in this study. Following this model in the control group the traditional method was applied to teach statistics…

Energetic and Environmental Impacts Related to Transport and Assembling Processes in ABiogas Production Plant from Marine Macroalgae (FP7 Project BioWALK4Biofuels)

NASA Astrophysics Data System (ADS)

Cappelli, Andrea; Gigli, Emanuele; Muzi, Luca; Renda, Roberto; Simoni, Silvano

2010-01-01

GHG emissions, eutrophication and energy dependence are problems that the EU has to face in the near future. The BioWALK4Biofuels project aims to find a common response to these challenges, taking advantage of spontaneous biological processes: the growth of algae and anaerobic digestion of biomass. This project is being built thanks to European funding under the 7th Framework Programme. To evaluate the results obtained, a first LCA study was carried out that, as regards the data on infrastructure and on the assembly of the plant, refers to data supplied by manufacturers, while the study of algal growth was made on the basis of a model of cultivation that takes account of the aspects that most affect this key process among all the ones that cooperate in the whole plant. The electricity and heat produced through a co-generator fueled by biogas produced from algal biomass, according to this study, are responsible for GHG emissions reduced by 52% compared to traditional technologies. The biogas produced during the 4 years of the project allows the substitution of 85 tonnes of oil equivalent (toe).

Material Development and Meeting Learner's Need

ERIC Educational Resources Information Center

Aydin, Abdullah

2013-01-01

In this study, the aim was to show that learners' needs can be met using simple and cheap materials that can be found everywhere in 9th to 11th grade Chemistry courses. To this end, materials were developed using simple everyday life materials for 9th to 11th grade Chemistry courses. In the research, the project method was employed. The study was…

17. 4th floor roof, view south, 4th and 5th floor ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. 4th floor roof, view south, 4th and 5th floor setback to left and atrium structure to right - Sheffield Farms Milk Plant, 1075 Webster Avenue (southwest corner of 166th Street), Bronx, Bronx County, NY

Critical analysis of documentary sources for Historical Climatology of Northern Portugal (17th-19th centuries)

NASA Astrophysics Data System (ADS)

Amorim, Inês; Sousa Silva, Luís; Garcia, João Carlos

2017-04-01

Critical analysis of documentary sources for Historical Climatology of Northern Portugal (17th-19th centuries) Inês Amorim CITCEM, Department of History, Political and International Studies, U. of Porto, Portugal. Luís Sousa Silva CITCEM, PhD Fellowship - FCT. João Carlos Garcia CIUHCT, Geography Department, U. of Porto, Portugal. The first major national project on Historical Climatology in Portugal, called "KLIMHIST: Reconstruction and model simulations of past climate in Portugal using documentary and early instrumental sources (17th-19th centuries)", ended in September 2015, coordinated by Maria João Alcoforado. This project began in March 2012 and counted on an interdisciplinary team of researchers from four Portuguese institutions (Centre of Geographical Studies, University of Trás-os-Montes and Alto Douro, University of Porto, and University of Évora), from different fields of knowledge (Geography, History, Biology, Climatology and Meteorology). The team networked and collaborated with other international research groups on Climate Change and Historical Climatology, resulting in several publications. This project aimed to reconstruct thermal and rainfall patterns in Portugal between the 17th and 19th centuries, as well as identify the main hydrometeorological extremes that occurred over that period. The basic methodology consisted in combining information from different types of anthropogenic sources (descriptive and instrumental) and natural sources (tree rings and geothermal holes), so as to develop climate change models of the past. The data collected were stored in a digital database, which can be searched by source, date, location and type of event. This database, which will be made publically available soon, contains about 3500 weather/climate-related records, which have begun to be studied, processed and published. Following this seminal project, other initiatives have taken place in Portugal in the area of Historical Climatology, namely a PhD project, still in progress, which also aims at the study of climatic variations and extreme hydrometeorological events in Northern Portugal, in the period prior to the creation of the organized network of meteorological stations and the systematization of instrumental observations (19th century). Therefore, in this communication we intend to present some of the documentary sources (private and institutional) used in the course of these projects. We will analyze the potentialities and limitations of a wide range of documentary sources, such as annals, memoirs and chronicles, daily weather reports, newspapers, book of judgments, economic records, correspondence, among others, and examine the various types of meteorological information we can from each of them, as well as the care to be taken in their use. Keywords: Modern Period, archive sources, climatic variations, hydrometeorological extremes, Portugal.

EU-funded malaria research under the 6th and 7th Framework Programmes for research and technological development.

PubMed

Holtel, Andreas; Troye-Blomberg, Marita; Penas-Jimenez, Inmaculada

2011-01-14

While malaria research has traditionally been strong in Europe, targeted and sustained support for cooperative malaria research at EU level, namely through the EU's 6th and 7th Framework Programmes for research and technological development, FP6 (2002-2006) and FP7 (2007-2013), has boosted both impact and visibility of European malaria research. Most of the European malaria research community is now organized under a number of comprehensive and complementary research networks and projects, assembled around four key areas: (1) fundamental research on the malaria parasite and the disease, (2) development of new malaria drugs, (3) research and development of a malaria vaccine, and (4) research to control the malaria-transmitting mosquito vector. Considerable efforts were undertaken to ensure adequate participation of research groups from disease-endemic countries, in particular from Africa, with the long-term aim to strengthen cooperative links and research capacities in these countries. The concept of organizing European research through major strategic projects to form a "European Research Area" (ERA) was originally developed in the preparation of FP6, and ERA formation has now turned into a major EU policy objective explicitly inscribed into the Lisbon Treaty. EU-funded malaria research may serve as a showcase to demonstrate how ERA formation can successfully be implemented in a given area of science when several surrounding parameters converge to support implementation of this strategic concept: timely coincidence of political stimuli, responsive programming, a clearly defined--and well confined--area of research, and the readiness of the targeted research community who is well familiar with transnational cooperation at EU level. Major EU-funded malaria projects have evolved into thematic and organizational platforms that can collaborate with other global players. Europe may thus contribute more, and better, to addressing the global research agenda for malaria.

Project CHOICE: #62. A Career Unit for Grades 5 and 6. Hospitals. (Health Occupations Career Cluster).

ERIC Educational Resources Information Center

Kern County Superintendent of Schools, Bakersfield, CA.

This teaching unit, Hospitals, is one in a series of curriculum guides developed by Project CHOICE (Children Have Options in Career Education) to provide the classroom teacher with a source of career-related activities linking 5th and 6th grade elementary classroom experiences with the world of work. These eight lessons on hospitals cover the…

Theodore Roosevelt High School, Project C.H.A.S.P. O.E.E. Evaluation Report, 1982-1983.

ERIC Educational Resources Information Center

Sjostrom, Barbara R.; Schulman, Robert

In 1982-83, Project CHASP offered bilingual instruction and support services to 100 Cambodian and 75 Hispanic limited-English-speaking students in the 9th and 10th grades at Theodore Roosevelt High School, Bronx, New York. The goal of the program was to develop student proficiency in the English language skills necessary for full mainstreaming…

THE PRE-TECHNICAL PROJECT, A DEMONSTRATION IN EDUCATION FOR TECHNOLOGY. MEDICAL TECHNOLOGY, 11TH AND 12TH YEAR.

ERIC Educational Resources Information Center

New York City Board of Education, Brooklyn, NY.

MEDICAL TECHNOLOGY IS ONE OF THREE OFFERINGS OF THE PRETECHNICAL PROJECT DESIGNED TO REMOTIVATE UNDERACHIEVING HIGH SCHOOL STUDENTS WHO, UPON SUCCESSFUL COMPLETION OF THE PROGRAM, MAY BE ADMITTED TO THE CAREER PROGRAMS OF THE COMMUNITY COLLEGE. DEVELOPED BY A COMMITTEE OF TEACHERS AT THE LOCAL LEVEL, THE MANUAL IS INTENDED TO ASSIST TEACHERS,…

The Effect of Project-Based Learning on Students' Statistical Literacy Levels for Data Representation

ERIC Educational Resources Information Center

Koparan, Timur; Güven, Bülent

2015-01-01

The point of this study is to define the effect of project-based learning approach on 8th Grade secondary-school students' statistical literacy levels for data representation. To achieve this goal, a test which consists of 12 open-ended questions in accordance with the views of experts was developed. Seventy 8th grade secondary-school students, 35…

The Effect of Project Based Learning in "Ratio, Proportion and Percentage" Unit on Mathematics Success and Attitude

ERIC Educational Resources Information Center

Özdemir, Ahmet Sükrü; Yildiz, Filiz; Yildiz, Sevda Göktepe

2015-01-01

In this paper, our aim is to examine the effect of project based learning on 7th grade students' mathematical success in "Ratio, Proportion and Percentage" unit and attitudes towards mathematics. This study was implemented with 70 7th grade students of Atatürk Primary School in Eminönü District in Istanbul. Before starting the…

Project CHOICE: #67. A Career Unit for Grades 5 and 6. Introduction to Advertising. (Marketing and Distribution Occupations Career Cluster).

ERIC Educational Resources Information Center

Kern County Superintendent of Schools, Bakersfield, CA.

This teaching unit, Introduction to Advertising, is one in a series of curriculum guides developed by Project CHOICE (Children Have Options in Career Education) to provide the classroom teacher with a source of career-related activities linking 5th and 6th grade elementary classroom experiences with the world of work. These ten lessons on…

Human Brain Proteome Project - 12th HUPO BPP Workshop. 26 September 2009, Toronto, Canada.

PubMed

Gröttrup, Bernd; Eisenacher, Martin; Stephan, Christian; Marcus, Katrin; Lee, Bonghee; Meyer, Helmut E; Park, Young Mok

2010-06-01

The HUPO Brain Proteome Project (HUPO BPP) held its 12th workshop in Toronto on 26 September 2009 prior to the HUPO VIII World Congress. The principal aim of this project is to obtain a better understanding of neurodiseases and ageing, with the ultimate objective of discovering prognostic and diagnostic biomarkers, in addition to the development of novel diagnostic techniques and new medications. The attendees came together to discuss progress in the human clinical neuroproteomics and to define the needs and guidelines required for more advanced proteomic approaches.

Space Shuttle Projects

NASA Image and Video Library

1989-07-24

Five astronauts composed the STS-28 crew. Seated from left to right are Richard N. (Dick) Richards, pilot; Brewster H. Shaw, commander; and David C. Leestma, mission specialist 2. Standing, from left to right , are Mark N. Brown, mission specialist 3; and James C. (Jim) Adamson, mission specialist 1. Launched aboard the Space Shuttle Columbia on August 8, 1989, the STS-28 mission was the 4th mission dedicated to the Department of Defense.

A Case Study of University Students' Use of Flickr Photographic Networking to Develop Confidence, English Language Fluency and Shape World Consciousness

ERIC Educational Resources Information Center

Graham, Steven

2009-01-01

One class of 4th year English major students who are part of the Bachelor of Education programme at Udon Thani Rajabhat University volunteered to participate in a project designed to increase their writing fluency whilst exposing them to different people and cultures in Southeast Asia. A secondary objective was to give an enjoyable task based…

"The Most Famous Brain in the World" Performance and Pedagogy on an Amnesiac's Brain

ERIC Educational Resources Information Center

Sweaney, Katherine W.

2012-01-01

Project H.M. was just the sort of thing one might expect the Internet to latch onto: it was a live streaming video of a frozen human brain being slowly sliced apart. Users who clicked the link on Twitter or Facebook between the 2nd and 4th of December 2009 were immediately confronted with a close-up shot of the brain's interior, which was…

Project CHECO Southeast Asia Report. Operation Attleboro

DTIC Science & Technology

1967-04-14

By the early morning of the 5th, the 273rd VC Regiment was once again 3 18-.... I A~POALI ~~llajor Enemy Contacts 0 S& , Ir iT~~~g I~c Srok Ca6 s6o...321 machetes, 1 VC flag, 1 chemical agent treatment kit, 1 -ton trail- er, 4 gas masks, 1 farm tractor, 1 pig, 1 set scales, 1 pr binoculars, 2

Oak Ridge National Laboratory [ORNL] Review, Vol. 25, Nos. 3 and 4, 1992 [The First Fifty Years

DOE R&D Accomplishments Database

Krause, C.(ed.)

1992-01-01

In observation of the 50th anniversary of Oak Ridge National Laboratory, this special double issue of the Review contains a history of the Laboratory, complete with photographs, drawings, and short accompanying articles. Table of contents include: Wartime Laboratory; High-flux Years; Accelerating Projects; Olympian Feats; Balancing Act; Responding to Social Needs; Energy Technologies; Diversity and Sharing; Global Outreach; Epilogue

Spotlight on GME/GHSE Supported Research

DTIC Science & Technology

2017-12-07

REPORT TYPE 3. DATES COVERED (From- To) 12/07/2017 Poster 4. TITLE AND SUBTITLE Sa. CONTRACT NUMBER Spotlight on GME/GHSE-Supported Research Sb...Clinical Research Division ., 4t€t.>Jc~"-\\. ~[lJI~IT~&[L IT~W~~UIT@&lYIT©~~ ~~@@~[RJ ~[0@1J[LI1@ 1r (Q)~ @~ An example of a "Parent" 59 MDW/ST R&D Project...ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION 59th Clinical Research Division REPORT NUMBER 1100 Willford Hall Loop, Bldg 4430 JBSA

Advanced Transformer Demonstration And Validation Project Summary Report Based On Experiences At Nas, North Island, San Diego. California

DTIC Science & Technology

1992-08-01

MAXIMIUI• 0 P 8. ALL LIGHTS ARE LED"’ TORMAD TEM"ERATUE TO RESET 9. DIGITAL METER IS LE[in EMORY IETER WILL AUTOMATICALLY MAD PHASE WiTH HIGHEST...in place. 4.4 Building 379 The Building 379 installation consisted of removing three existing 167 kVA PCB-filled, single phase , polemount transformers...that were connected in a three phase bank and replacing them with a single 300 kVA Square D Company VPI dry-type transformer. This task also involved

Pros-IT CNR: an Italian prostate cancer monitoring project.

PubMed

Noale, Marianna; Maggi, Stefania; Artibani, Walter; Bassi, Pier Francesco; Bertoni, Filippo; Bracarda, Sergio; Conti, Giario Natale; Corvò, Renzo; Gacci, Mauro; Graziotti, Pierpaolo; Magrini, Stefano Maria; Maurizi Enrici, Riccardo; Mirone, Vincenzo; Montironi, Rodolfo; Muto, Giovanni; Pecoraro, Stefano; Porreca, Angelo; Ricardi, Umberto; Tubaro, Andrea; Zagonel, Vittorina; Zattoni, Filiberto; Crepaldi, Gaetano

2017-04-01

The Pros-IT CNR project aims to monitor a sample of Italian males ≥18 years of age who have been diagnosed in the participating centers with incident prostate cancer, by analyzing their clinical features, treatment protocols and outcome results in relation to quality of life. Pros-IT CNR is an observational, prospective, multicenter study. The National Research Council (CNR), Neuroscience Institute, Aging Branch (Padua) is the promoting center. Ninety-seven Italian centers located throughout Italy were involved. The field study began in September 1, 2014. Subjects eligible were diagnosed with biopsy-verified prostate cancer, naïve. A sample size of 1500 patients was contemplated. A baseline assessment including anamnestic data, clinical history, risk factors, the initial diagnosis, cancer staging information and quality of life (Italian UCLA Prostate Cancer Index; SF-12 Scale) was completed. Six months after the initial diagnosis, a second assessment evaluating the patient's health status, the treatment carried out, and the quality of life will be made. A third assessment, evaluating the treatment follow-up and the quality of life, will be made 12 months after the initial diagnosis. The 4th, 5th, 6th and 7th assessments, similar to the third, will be completed 24, 36, 48 and 60 months after the initial diagnosis, respectively, and will include also a Food Frequency Questionnaire and the Physical Activity Scale for the Elderly. The study will provide information on patients' quality of life and its variations over time in relation to the treatments received for the prostate cancer.

Climatic trends over Ethiopia: regional signals and drivers

USGS Publications Warehouse

Jury, Mark R.; Funk, Christopher C.

2013-01-01

This study analyses observed and projected climatic trends over Ethiopia, through analysis of temperature and rainfall records and related meteorological fields. The observed datasets include gridded station records and reanalysis products; while projected trends are analysed from coupled model simulations drawn from the IPCC 4th Assessment. Upward trends in air temperature of + 0.03 °C year−1 and downward trends in rainfall of − 0.4 mm month−1 year−1 have been observed over Ethiopia's southwestern region in the period 1948-2006. These trends are projected to continue to 2050 according to the Geophysical Fluid Dynamics Lab model using the A1B scenario. Large scale forcing derives from the West Indian Ocean where significant warming and increased rainfall are found. Anticyclonic circulations have strengthened over northern and southern Africa, limiting moisture transport from the Gulf of Guinea and Congo. Changes in the regional Walker and Hadley circulations modulate the observed and projected climatic trends. Comparing past and future patterns, the key features spread westward from Ethiopia across the Sahel and serve as an early warning of potential impacts.

Progresses in neuroproteomics of neurodegenerative diseases--18th HUPO BPP workshop: September 12, 2012, Boston, USA.

PubMed

Gröttrup, Bernd; May, Caroline; Meyer, Helmut E; Grinberg, Lea T; Park, Young Mok

2013-01-01

The HUPO Brain Proteome Project (HUPO BPP) held its 18(th) workshop in Boston, USA, September 12(th) 2012 during the HUPO 11th Annual Word Congress. The focus was on the progress on the Human Brain Proteome Atlas as well as ideas, strategies and methodological aspects. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Diurnal Cycle of Convection and Interaction with the Large-Scale Circulation

NASA Technical Reports Server (NTRS)

Salby, Murry

2002-01-01

The science in this effort was scheduled in the project's 3rd and 4th years, after a long record of high-resolution Global Cloud Imagery (GCI) had been produced. Unfortunately, political disruptions that interfered with this project led to its funding being terminated after only two years of support. Nevertheless, the availability of intermediate data opened the door to a number of important scientific studies. Beyond considerations of the diurnal cycle addressed in this grant, the GCI wakes possible a wide range of studies surrounding convection, cloud and precipitation. Several are already underway with colleagues in the US and abroad, who have requested the GCI.

An overview of results from the GEWEX radiation flux assessment

NASA Astrophysics Data System (ADS)

Raschke, E.; Stackhouse, P.; Kinne, S.; Contributors from Europe; the USA

2013-05-01

Multi-annual radiative flux averages of the International Cloud Climatology Project (ISCCP), of the GEWEX - Surface Radiation Budget Project (SRB) and of the Clouds and Earth Radiative Energy System (CERES) are compared and analyzed to characterize the Earth's radiative budget, assess differences and identify possible causes. These satellite based data-sets are also compared to results of a median model, which represents 20 climate models, that participated in the 4th IPCC assessment. Consistent distribution patterns and seasonal variations among the satellite data-sets demonstrate their scientific value, which would further increase if the datasets would be reanalyzed with more accurate and consistent ancillary data.

Smith Newton Vehicle Performance Evaluation – 4th Quarter 2013; NREL (National Renewable Energy Laboratory)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2014-01-01

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

Proceedings of the SDIO/ONR Pulse Power Meeting (4th) Held in Los Angeles, California on June 20-21, 1991

DTIC Science & Technology

1991-06-01

8217sýs its contactýs did not go to zero Instead. it dropped to a ,e.iiconductor laser diode arra .2 .&DL/ L , L CEl "S 26 kV PCSS +200 ’ ’ f5of2 .... 0... Project at the Laboratory for Laser Energetics, as well as by the NSF grant DMR-8913524. 61 BIOGRAPHIES Princeton University in 1974 and the Ph.D...Sponsors of the Laser Fusion F. Rose, (IEEE, New York, 1985), Feasibility Project at the Laboratory for Laser p. 242. Energetics. The samples were provided

Development of In Vitro Systems for Switchgrass (Panicum virgatum) - Final Report for 1992 to 2002

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conger, B.V.

2003-01-16

Our project began on July 1, 1992, with the objective of developing systems that could be used in biotechnological approaches to switchgrass improvement. Within six months after initiation of the project, we had worked out protocols in which plants could be regenerated from callus cultures through both organogenesis and somatic embryogenesis. Documentation for both modes of regeneration was provided in our progress reports and in publications. One thousand regenerated plants were established in the field during the first year. We found that Alamo (lowland type) was much more amenable to in vitro culture, and plants could be regenerated much moremore » easily than from Cave-in-Rock (upland type). During the first three years of the project, we studied the influence of genotype, culture medium components, explant type, etc., on regeneration. As mentioned, we found that the lowland cultivars Alamo and Kanlow were much easier to regenerate than upland cultivars, such as Trailblazer, Blackwell, and Cave-in-Rock. For callus induction, we initially used mature caryopses, young leaf tissue, and portions of seedlings. We were successful in inducing callus and regenerating plants from all explants. Two other systems developed during the 4th to 6th year period of the project included multiple shoot formation initiated from germinated seedlings and regenerable suspension cultures. The latter were initiated from embryogenic calluses produced from in vitro developed inflorescences. An important factor for producing multiple shoots was the presence of thidiazuron in the medium. The shoots could be easily rooted and numerous plantlets produced. The last 3 to 4 years of the project focused on anther and microspore culture experiments to produce haploid plants and on genetic transformation. Although thousands of putative haploid plants were produced from a few anthers, they were very weak and difficult to keep alive. Chromosome counts revealed the gametic number in cells where it was possible to count chromosomes. The isolated microspore culture experiments were not successful.« less

Project CHECO Southeast Asia Report. Rules of Engagement - 1 January 1966 - 1 November 1969

DTIC Science & Technology

1969-08-31

O.owngrading of Project CIIECO Report TO: AAC ADC AFAFC AFLC ( Historian ) AFRES AFSC ATC All t-IAC PACAF SAC TAC USA FE USAFSS...k. , ~. t ~ s ipso [aoto a moto ¥>ab?.~ road or· naH. Sc.. an!:fpt-:.~.-.:r,: th:..tt !fOU find a veh-;.cle~ d .;·( .~a’l a5JIOI~ th:u 1..t ~-;f

Project CHOICE: #50. A Career Education Unit for Fifth and Sixth Grades. Introduction to Clothing Design. (Fine Arts and Humanities Career Cluster).

ERIC Educational Resources Information Center

Kern County Superintendent of Schools, Bakersfield, CA.

This teaching unit, Introduction to Clothing Design, is one in a series of curriculum guides developed by Project CHOICE (Children Have Options in Career Education) to provide the classroom teacher with a source of career-related activities linking 5th and 6th grade elementary classroom experiences with the world of work. These ten clothing design…

The MOOC-CLIL Project: Using MOOCs to Increase Language, and Social and Online Learning Skills for 5th Grade K-12 Students

ERIC Educational Resources Information Center

de Waard, Inge; Demeulenaere, Kathy

2017-01-01

This study comprises the outcomes and methods of a one year project using Content and Language Integrated Learning (CLIL) and Massive Open Online Courses (MOOCs) embedded in K-12 classes. The Self-Regulated Learning (SRL) of 42 students enrolled in three 5th grade classes were monitored. The students took the MOOCCLIL class for one year…

Status of India's population education programme--the subject of tripartite projects review and annual country review.

PubMed

1981-12-01

A 3-step monitoring of India's population education program was undertaken in 1981 in order to determine the level of implementation and progress of the program. This monitoring program, conducted by the Unesco Mobile Team in collaboration with other institutions, followed 3 procedures: Project Progress Report (PPR); Tripartite Project Review (TPR); and Annual Country Review (ACR). The review meetings of the 10 state population education projects were organized at Chandigarh and Madras during August. The states covered in the review were Bihar, Haryana, Madhaya Pradesh, Punjab, Rajasthan, Chandigarh, Gujarat, Karnataka, Maharashtra, and Tamil Nadu. The Tripartite Review identified the following as problems which were hindering the smooth implementation of the population education program: 1) difficulty in spending funds unless certain formalities were completed by the governments of the states; 2) administrative problems such as getting printing paper for instructional materials, waiving the sales tax for equipment to be purchased under the project, and uncertainty regarding the admissible rates of per diem to be paid to the participants in various training programs; 3) the lack of experience of project staff; 4) problems created by having more than 1 cell in a state such as Rajasthan; and 5) an inadequate time frame within which the project should complete all its activities and make population education an integral part of the school system. The following were among the recommendations made: 1) the Project should be made coterminous with the 6th Five-Year Plan up to March 31, 1985; and 2) there should be only 1 Population Education Cell in every state. Among the points discussed at the annual country review, held during October, were the following: rephasing of the program from a 3 to 5 year project to synchronize it with the 6th plan; and the need for additional funds in view of inflation.

Boom Time.

ERIC Educational Resources Information Center

Agron, Joe

1998-01-01

Examines building-cost trend data for educational facilities from the American School & University's 24th annual Official Education Construction Report for 1997. Data tables list education construction by projects completed; by projected spending; institution type; type of spending; projects projected for completion; and how construction costs…

Preferential susceptibility of Th9 and Th2 CD4+ T cells to X4-tropic HIV-1 infection.

PubMed

Orlova-Fink, Nina; Chowdhury, Fatema Z; Sun, Xiaoming; Harrington, Sean; Rosenberg, Eric S; Yu, Xu G; Lichterfeld, Mathias

2017-10-23

The functional polarization of CD4 T cells determines their antimicrobial effector profile, but may also impact the susceptibility to infection with HIV-1. Here, we analyzed the susceptibility of CD4 T cells with different functional polarization to infection with X4 and R5-tropic HIV-1. CD4 T cells with a Th1, Th2, Th17, and Th9 polarization were subjected to in-vitro infection assays with X4, R5, or vesicular stomatitis virus-G protein-pseudotyped HIV-1. In addition, we sorted differentially polarized CD4 T-cell subsets from individuals treated with antiretroviral therapy and analyzed the tropism of viral env sequences. Th9-polarized CD4 T cells and, to a lesser extent, Th2-polarized CD4 T cells expressed higher surface levels of CXCR4, and are more permissive to X4-tropic infection in vitro. In contrast, Th1 and Th17 CD4 T cells exhibited stronger surface expression of CCR5, and were more susceptible to infection with R5-tropic viruses. Correspondingly, the distribution of X4-tropic viral sequences in antiretroviral therapy-treated HIV-1-infected patients was biased toward Th9/Th2 cells, whereas R5-tropic sequences were more frequently observed in Th17 cells. CD4 T-cell polarization is associated with a distinct susceptibility to X4 and R5-tropic HIV-1 infection.

Expression of tyrosine hydroxylase in CD4+ T cells contributes to alleviation of Th17/Treg imbalance in collagen-induced arthritis.

PubMed

Wang, Xiao-Qin; Liu, Yan; Cai, Huan-Huan; Peng, Yu-Ping; Qiu, Yi-Hua

2016-12-01

Tyrosine hydroxylase (TH), a rate-limiting enzyme for the synthesis of catecholamines, is expressed in T lymphocytes. However, the role of T cell-expressed TH in rheumatoid arthritis (RA) is less clear. Herein, we aimed to show the contribution of TH expression by CD4 + T cells to alleviation of helper T (Th)17/regulatory T (Treg) imbalance in collagen-induced arthritis (CIA), a mouse model of RA. CIA was prepared by intradermal injection of collagen type II (CII) at tail base of DBA1/J mice. Expression of TH in the spleen and the ankle joints was measured by real-time polymerase chain reaction and Western blot analysis. Percentages of TH-expressing Th17 and Treg cells in splenic CD4 + T cells were determined by flow cytometry. Overexpression and knockdown of TH gene in CD4 + T cells were taken to evaluate effects of TH on Th17 and Treg cells in CIA. TH expression was upregulated in both the inflamed tissues (spleen and ankle joints) and the CD4 + T cells of CIA mice. In splenic CD4 + T cells, the cells expressing TH were increased during CIA. These cells that expressed more TH in CIA were mainly Th17 cells rather than Treg cells. TH gene overexpression in CD4 + T cells from CIA mice reduced Th17 cell percentage as well as Th17-related transcription factor and cytokine expression and secretion, whereas TH gene knockdown enhanced the Th17 cell activity. In contrast, TH gene overexpression increased Treg-related cytokine expression and secretion in CD4 + T cells of CIA mice, while TH gene knockdown decreased the Treg cell changes. Collectively, these findings show that CIA induces TH expression in CD4 + T cells, particularly in Th17 cells, and suggest that the increased TH expression during CIA represents an anti-inflammatory mechanism.

Extraction of Uranium from Seawater: Design and Testing of a Symbiotic System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Slocum, Alex

The U.S. Department of Energy in October 2014 awarded the Massachusetts Institute of Technology (MIT) a Nuclear Energy University Program grant (DE-NE0008268) to investigate the design and testing of a symbiotic system to harvest uranium from seawater. As defined in the proposal, the goals for the project are: 1. Address the design of machines for seawater uranium mining. 2. Develop design rules for a uranium harvesting system that would be integrated into an offshore wind power tower. 3. Fabricate a 1/50th size scale prototype for bench and pool-testing to verify initial analysis and theory. 4. Design, build, and test amore » second 1/10th size scale prototype in the ocean for more comprehensive testing and validation. This report describes work done as part of DE-NE0008268 from 10/01/2014 to 11/30/2017 entitled, “Extraction of Uranium from Seawater: Design and Testing of a Symbiotic System.” This effort is part of the Seawater Uranium Recovery Program. This report details the publications and presentations to date on the project, an introduction to the project’s goals and background research into previous work done to achieve these goals thus far. From there, the report describes an algorithm developed during the project used to optimize the adsorption of uranium by changing mechanical parameters such as immersion time and adsorbent reuses is described. Next, a design tool developed as part of the project to determine the global feasibility of symbiotic uranium harvesting systems. Additionally, the report details work done on shell enclosures for uranium adsorption. Moving on, the results from the design, building, and testing of a 1/50th physical scale prototype of a highly feasible symbiotic uranium harvester is described. Then, the report describes the results from flume experiment used to determine the affect of enclosure shells on the uptake of uranium by the adsorbent they enclose. From there the report details the design of a Symbiotic Machine for Ocean uRanium Extraction (SMORE). Next, the results of the 1/10th scale physical scale prototype of a highly feasible symbiotic uranium harvester are presented. The report then details the design and results of an experiment to examine the hydrodynamic effects of a uranium harvester on the offshore wind turbine it is attached to using a 1/150th Froude scale tow tank test. Finally, the report details the results of an initial cost-analysis for the production of uranium from seawater from such a symbiotic device.« less

Clinical aspects of neurodegenerative diseases - 15th HUPO BPP Workshop April 8-9, 2011, Bochum, Germany.

PubMed

Gröttrup, Bernd; Böckmann, Miriam; Marcus, Katrin; Wiltfang, Jens; Grinberg, Lea T; Meyer, Helmut E; Park, Young M

2011-11-01

The HUPO Brain Proteome Project (HUPO BPP) held its 15th workshop in Bochum, Germany, from April 8th to 9th, 2011 directly after the Proteomic Forum 2011 in Berlin. Like on every spring workshop, the focus was more on clinical aspects, so that especially clinicians participated in this workshop. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Comparison of lung tumor motion measured using a model-based 4DCT technique and a commercial protocol.

PubMed

O'Connell, Dylan; Shaverdian, Narek; Kishan, Amar U; Thomas, David H; Dou, Tai H; Lewis, John H; Lamb, James M; Cao, Minsong; Tenn, Stephen; Percy, Lee P; Low, Daniel A

To compare lung tumor motion measured with a model-based technique to commercial 4-dimensional computed tomography (4DCT) scans and describe a workflow for using model-based 4DCT as a clinical simulation protocol. Twenty patients were imaged using a model-based technique and commercial 4DCT. Tumor motion was measured on each commercial 4DCT dataset and was calculated on model-based datasets for 3 breathing amplitude percentile intervals: 5th to 85th, 5th to 95th, and 0th to 100th. Internal target volumes (ITVs) were defined on the 4DCT and 5th to 85th interval datasets and compared using Dice similarity. Images were evaluated for noise and rated by 2 radiation oncologists for artifacts. Mean differences in tumor motion magnitude between commercial and model-based images were 0.47 ± 3.0, 1.63 ± 3.17, and 5.16 ± 4.90 mm for the 5th to 85th, 5th to 95th, and 0th to 100th amplitude intervals, respectively. Dice coefficients between ITVs defined on commercial and 5th to 85th model-based images had a mean value of 0.77 ± 0.09. Single standard deviation image noise was 11.6 ± 9.6 HU in the liver and 6.8 ± 4.7 HU in the aorta for the model-based images compared with 57.7 ± 30 and 33.7 ± 15.4 for commercial 4DCT. Mean model error within the ITV regions was 1.71 ± 0.81 mm. Model-based images exhibited reduced presence of artifacts at the tumor compared with commercial images. Tumor motion measured with the model-based technique using the 5th to 85th percentile breathing amplitude interval corresponded more closely to commercial 4DCT than the 5th to 95th or 0th to 100th intervals, which showed greater motion on average. The model-based technique tended to display increased tumor motion when breathing amplitude intervals wider than 5th to 85th were used because of the influence of unusually deep inhalations. These results suggest that care must be taken in selecting the appropriate interval during image generation when using model-based 4DCT methods. Copyright © 2017 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.

Changes of Climate Extremes in Urmia Lake Basin: Observations and Multimodel Ensemble Projections

NASA Astrophysics Data System (ADS)

Ashraf, B.; AghaKouchak, A.

2017-12-01

This study presents an analysis of the changes in temperature and precipitation extremes in Urmia Lake Basin, in Iran in 21th century. The latest observations in the past three decades and multimodel ensemble projections from eleven General Circulation Models (GCMs) under the three Representative Concentration Pathways (RCPs) 2.6, 4.5 and 8.5 scenarios are employed for analysis in this study. The twenty-seven indicative temperature and precipitation indices recommended by the joint World Meteorological Organization CCL/CLIVAR/JCOMM Expert Team on Climate Change Detection and Indices (ETCCDI) were used for assessing changes in extremes. Results indicate that most warm (cold) extreme temperature indices have shown significantly positive (negative) trends in the Urmia Lake Basin in past three decades, while only slight changes in precipitation extremes can be observed. Ensemble projection from Bayesian Model Averaging (BMA) of Phase 5 of the Coupled Model Intercomparison Project (CMIP5) suggests that the increasing consecutive dry days (CDD), together with the decreasing frost day (FD) and increasing warm nights frequency (TN90) contribute to more frequent/severe droughts in Urmia Lake Basin. Meanwhile, the results show slight increase of annual count of days with precipitation of more than 10 mm (R10), maximum 5-day precipitation total (R5D), simple daily intensity index (SDII), and annual total precipitation with precipitation >95th percentile (R95) in projections. Our finding provides information on how extremes might change in the future from a wide range of scenarios that can potentially be sued for water resource and eco-environmental planning and adaptation strategies.

The Hand of God in Socaire

NASA Astrophysics Data System (ADS)

Moyano, Ricardo

2016-11-01

We present preliminary results obtained from a spatio-temporal analysis of mountain worship directions at the Atacama Indian community of Socaire, northern Chile (23°35'28''S, 67°52'36''W, 3,274 masl). These results can be linked to cultural, geographical, climatic, psychological and astronomical information from ethno-archaeological data. We propose a"system of offering to mountains" that includes concepts such as ceque (straight line), mayllku or mallku (mountain lord or ancestor), and pacha (space and time), which is understood as the projection of a left human hand in the visible horizon (Tumisa, Lausa, Chiliques, Ipira and Miñiques Mountains) (PAH-Triad). This system regulates annual activities such as planting (August 1st), harvesting (May 1st), cleansing of irrigation channels (October 24-26th), and the Catholic rituals and festivities of Saint Bartholomew (August 24th), Saint Barbara (December 4th), Christmas-Summer solstice (December 25th), Carnival (between February and March), Holy Cross (May 3rd), and Saint John-Winter solstice (June 24th). More importantly: it gives a basis for Socaireños' worldview including categories of"above, here, and down";"right and left";"female and male";"noon and midnight";"north and south";"visible and non-visible", along with the Andean concepts of center (ushnu);"two, three, four and five division"; and"humanized landscape".

Projections of Education Statistics to 2021. Fortieth Edition. NCES 2013-008

ERIC Educational Resources Information Center

Hussar, William J.; Bailey, Tabitha M.

2013-01-01

"Projections of Education Statistics to 2021" is the 40th report in a series begun in 1964. It includes statistics on elementary and secondary schools and postsecondary degree-granting institutions. This report provides revisions of projections shown in "Projections of Education Statistics to 2020" and projections of…

Comparative Test of the Effectiveness of Large Bombs against Reinforced Concrete Structures (Anglo-American Bomb Tests-Project RUBY).

DTIC Science & Technology

1946-10-31

be expected to perforate up to 15’-l0" of reinforced concreto at this striking velocity. (3) The rocket assisted 4500-lb. Disney bomb, with a striking...Aaedttted wer the ia&AlM srfase of th. bae" at tiehes- It~, is possibi,. thaltA We as OW Wae rleaketeI4" xibmaded ArM the avl.s )at Roe blsm autos

Simulation of Extreme Arctic Cyclones in IPCC AR5 Experiments

DTIC Science & Technology

2012-09-30

of the present-day Arctic atmosphere in CCSM4. J. Climate, 2676-2695. Overeem, I ., R . S. Anderson, C. W. Wobus, G. D. Clow, F. E. Urban, and N...intensity of extreme Arctic cyclones? APPROACH I am targeting these objectives through a retrospective analysis of the transient 20th century...simulations (spanning years 1850-2005) among the GCMs participating in the latest Coupled Model Intercomparison Project (CMIP5). I am including 14

Conversion of Solid Waste to Fuels

DTIC Science & Technology

1976-01-01

pyrolysis (cracking) of crude oil to gasolines. 14 Nelson. W. L., Petroleum Refinery Engineering, 4th Edition, New York, McGraw-Hill, p. 628, 1958. 17 I ...Approved for public release; distribution unlimited. ^ ij) I Naval Weapons Center CHINA LAKE, CALIFORNIA 93555 *ps*8iw*iliBHi w- yl» -—»- BEST...Commander G. L. Hollingsworth Technical Direrto, FOREWORD I ins report describes ; i solid waste research project conducted during the period KY73

How To Succeed in Promoting Your Web Site: The Impact of Search Engine Registration on Retrieval of a World Wide Web Site.

ERIC Educational Resources Information Center

Tunender, Heather; Ervin, Jane

1998-01-01

Character strings were planted in a World Wide Web site (Project Whistlestop) to test indexing and retrieval rates of five Web search tools (Lycos, infoseek, AltaVista, Yahoo, Excite). It was found that search tools indexed few of the planted character strings, none indexed the META descriptor tag, and only Excite indexed into the 3rd-4th site…

Environmental Assessment: 49th Materiel Maintenance Group BEAR Base Improvements Holloman Air Force Base, New Mexico

DTIC Science & Technology

2004-08-01

land clearing action will be an irreversible commitment of resources. 4.3.2 Water Quality Construction project impacts to storm water quality can...nearby monitored outfalls for the MSGP. High turbidity, suspended solids, and decreased cross section due to deposition can violate storm water quality benchmarks...and result in a Notice of Violation for storm water quality permits. Beside erosive impacts, construction period activities can cause

Space Shuttle Projects

NASA Image and Video Library

1991-08-02

Launched aboard the Space Shuttle Atlantis on August 2, 1991, the STS-43 mission’s primary payload was the Tracking and Data Relay Satellite 5 (TDRS-5) attached to an Inertial Upper Stage (IUS), which became the 4th member of an orbiting TDRS cluster. The flight crew consisted of 5 astronauts: John E. Blaha, commander; Michael A. Baker, pilot; Shannon W. Lucid, mission specialist 1; James C. Adamson, mission specialist 2; and G. David Low, mission specialist 3.

Space Shuttle Projects

NASA Image and Video Library

1991-08-02

Launched aboard the Space Shuttle Atlantis on August 2, 1991, the STS-43 mission’s primary payload was the Tracking and Data Relay Satellite 5 (TDRS-5) attached to an Inertial Upper Stage (IUS), which became the 4th member of an orbiting TDRS cluster. The flight crew consisted of five astronauts: John E. Blaha, commander; Michael A. Baker, pilot; Shannon W. Lucid, mission specialist 1; James C. Adamson, mission specialist 2; and G. David Low, mission specialist 3.

Public Law 94-103: 94th Congress, H.R. 4005, October 4, 1975. An Act to Amend the Developmental Disabilities Services and Facilities Construction Act to Revise and Extend the Programs Authorized by that Act.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate.

Presented is the 1975 amendment to the Developmental Disabilities Services and Facilities Construction Act. Described are revisions and extensions of the earlier act, including revision of grant and construction assistance for university affiliated facilities, and revision of special projects assistance. The earlier act's designation of rights of…

TM 4: Beam through the Main Linac Cryomodule

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bartnik, A.

2017-06-14

On May 15th 2017, the CBETA project reached the major funding milestone, “Beam through the MLC.” For this test, the team had to successfully accelerate the electron beam to 6 MeV in the Injector Cryomodule (ICM), and then to a final energy of 12 MeV in the Main Linac Cryomodule (MLC). The MLC contains six superconducting accelerating cavities; for this initial test only a single cavity was powered.

The South Carolina Amazing Coast Program: Using Ocean Sciences to Address Next Generation Science Standards in Grades 3-5

NASA Astrophysics Data System (ADS)

Bell, E. V.; Thomas, C.; Weiss, B.; Bliss, A.; Spence, L.

2013-12-01

The Next Generation Science Standards (NGSS) are more inclusive of ocean sciences than the National Science Standards and respective state science standards. In response, the Center for Ocean Sciences Education Excellence-SouthEast (COSEE SE) is piloting the South Carolina's Amazing Coast (SCAC) program: a three-year initiative that incorporates ocean science concepts in grades 3-5 with the goals of addressing NGSS, STEM (science-technology-engineering-math) disciplines, and inquiry skills. The SCAC program targeted two Charleston County, South Carolina elementary schools that were demographically similar: Title 1 status (75% free or reduced lunch), > 90% African American student population, grade level size <55, and proximity to tidal salt marsh or barrier islands (< 2 miles). Fourteen teachers and approximately 240 students participated in the SCAC program between 2010 and 2013. The SCAC framework uses a scaffolding and multi-pronged approach for teacher professional development and student engagement. The scaffolding approach to curriculum implementation focuses on one grade level per year (Year 1 = 3rd; Year 2 = 4th, and Year 3 = 5th), thus building student and teacher literacy in ocean sciences. The coach-mentor model of teacher professional development was also used for the implementation of the program which differs from the traditional 'train the trainer' method in allowing for more frequent and consistent interaction by COSEE SE staff with the students and teachers during the school year. The coach mentor model enabled the creation of a community of practice where teachers served as both learners and practitioners of student learning. Methods for student engagement aligned with the NGSS and included hands-on classroom activities, use of 'hook' species such as loggerhead sea turtles (Caretta caretta), diamondback terrapins (Malaclemys terrapin) and smooth cord grass (Spartina alterniflora), field experiences to explore local ecosystems, interactions with marine scientists, and a capstone project incorporating STEM and inquiry skills. Specifically, third grade students learn about coastal habitats, animal and plant adaptations, and human impacts to the environment, and engage in a salt marsh restoration capstone project. This part of the curriculum aligns with the NGSS Core Ideas 3-LS1, 3-LS3, 3-LS4, 3-ESS3. The fourth grade students learn about weather, organism responses to the environment, and engage in a weather buoy construction capstone project. This part of the curriculum aligns with the NGSSS Core Ideas 4-LS1, 4-ESS2, 4-ESS3, 3-5-ETS1. In 5th grade, students focus specifically on the ocean ecosystem, human impacts on the environment and engage in a capstone project of designing and constructing remotely operated vehicles. This part of the curriculum aligns with NGSS Core Ideas 5-PS2, 5-LS1, 5-LS2, 5-ESS2, 3-5-ETS1. Initial evaluation results indicate that the SCAC teachers value the coach mentor approach for teacher professional development as well as the impact of field based experiences, place-based learning, and a culminating capstone project on student learning. Teacher feedback also indicates elements of sustainability that extend beyond the scope of the pilot project.These initial evaluation results poise the SCAC curriculum to be replicated in other southeastern states.

A probabilistic analysis of cumulative carbon emissions and long-term planetary warming

DOE PAGES

Fyke, Jeremy Garmeson; Matthews, H. Damon

2015-11-16

Efforts to mitigate and adapt to long-term climate change could benefit greatly from probabilistic estimates of cumulative carbon emissions due to fossil fuel burning and resulting CO 2-induced planetary warming. Here we demonstrate the use of a reduced-form model to project these variables. We performed simulations using a large-ensemble framework with parametric uncertainty sampled to produce distributions of future cumulative emissions and consequent planetary warming. A hind-cast ensemble of simulations captured 1980–2012 historical CO 2 emissions trends and an ensemble of future projection simulations generated a distribution of emission scenarios that qualitatively resembled the suite of Representative and Extended Concentrationmore » Pathways. The resulting cumulative carbon emission and temperature change distributions are characterized by 5–95th percentile ranges of 0.96–4.9 teratonnes C (Tt C) and 1.4 °C–8.5 °C, respectively, with 50th percentiles at 3.1 Tt C and 4.7 °C. Within the wide range of policy-related parameter combinations that produced these distributions, we found that low-emission simulations were characterized by both high carbon prices and low costs of non-fossil fuel energy sources, suggesting the importance of these two policy levers in particular for avoiding dangerous levels of climate warming. With this analysis we demonstrate a probabilistic approach to the challenge of identifying strategies for limiting cumulative carbon emissions and assessing likelihoods of surpassing dangerous temperature thresholds.« less

Field evaluation of roller integrated intelligent compaction monitoring

DOT National Transportation Integrated Search

2016-05-01

DOTD conducted a demonstration : project to evaluate intelligent compaction (IC). The : project developed specifications, which allo : wed and incorporated : the IC rollers on the : project. The specification went through th : e competitive bidding p...

A fast, programmable hardware architecture for the processing of spaceborne SAR data

NASA Technical Reports Server (NTRS)

Bennett, J. R.; Cumming, I. G.; Lim, J.; Wedding, R. M.

1984-01-01

The development of high-throughput SAR processors (HTSPs) for the spaceborne SARs being planned by NASA, ESA, DFVLR, NASDA, and the Canadian Radarsat Project is discussed. The basic parameters and data-processing requirements of the SARs are listed in tables, and the principal problems are identified as real-operations rates in excess of 2 x 10 to the 9th/sec, I/O rates in excess of 8 x 10 to the 6th samples/sec, and control computation loads (as for range cell migration correction) as high as 1.4 x 10 to the 6th instructions/sec. A number of possible HTSP architectures are reviewed; host/array-processor (H/AP) and distributed-control/data-path (DCDP) architectures are examined in detail and illustrated with block diagrams; and a cost/speed comparison of these two architectures is presented. The H/AP approach is found to be adequate and economical for speeds below 1/200 of real time, while DCDP is more cost-effective above 1/50 of real time.

Saturn's 15th moon, 1980S28

NASA Technical Reports Server (NTRS)

1980-01-01

Voyager 1 has found a 15th moon orbiting Saturn, visible near the bottom of this picture taken on Nov. 6, 1980, when the spacecraft was still 8 million kilometers (5 million miles) from Saturn. Voyager imaging team scientists discovered the moon Nov. 7, 1980, in the first of several programmed searches for new satellites of Saturn. The unique location of the 15th satellite, just 800 kilometers (500 miles) outside the outer edge of the A-ring, is especially significant in that this small body, approximately 100 kilometers (50 miles) in diameter, may be responsible for defining the outer edge of Saturn's bright ring system. The orbital period of the new satellite is approximately 14 hours, 20 minutes, the shortest orbit of any of Saturn's known satellites. The very narrow F-ring, approximately 4,000 kilometers (2,500 miles) outside the outer edge of the A-ring, is seen prominently in this picture. The Voyager Project is managed for NASA by the Jet Propulsion Laboratory, Pasadena, Calif.

Circulation pattern-based assessment of projected climate change for a catchment in Spain

NASA Astrophysics Data System (ADS)

Gupta, Hoshin V.; Sapriza-Azuri, Gonzalo; Jódar, Jorge; Carrera, Jesús

2018-01-01

We present an approach for evaluating catchment-scale hydro-meteorological impacts of projected climate change based on the atmospheric circulation patterns (ACPs) of a region. Our approach is motivated by the conjecture that GCMs are especially good at simulating the atmospheric circulation patterns that control moisture transport, and which can be expected to change in response to global warming. In support of this, we show (for the late 20th century) that GCMs provide much better simulations of ACPs than those of precipitation amount for the Upper Guadiana Basin in central Spain. For the same period, four of the twenty GCMs participating in the most recent (5th) IPCC Assessment provide quite accurate representations of the spatial patterns of mean sea level pressure, the frequency distribution of ACP type, the 'number of rainy days per month', and the daily 'probability of rain' (they also reproduce the trend of 'wet day amount', though not the actual magnitudes). A consequent analysis of projected trends and changes in hydro-climatic ACPology between the late 20th and 21st Centuries indicates that (1) actual changes appear to be occurring faster than predicted by the models, and (2) for two greenhouse gas emission scenarios (RCP 4.5 and RCP 8.5) the expected decline in precipitation volume is associated mainly with a few specific ACPs (primarily directional flows from the Atlantic Ocean and Cantabric Sea), and with decreasing probability of rain (linked to increasing temperatures) rather than wet day amount. Our approach is a potentially more insightful alternative for catchment-scale climate impacts assessments than the common approach of statistical downscaling and bias correction.

The Northern Forest Futures Project: examining past, present, and future trends affecting forests in and around the central hardwood forest region

Treesearch

Stephen Shifley

2013-01-01

Th e Northern Forest Futures Project is intended to be a window on tomorrow's forests, revealing how today's trends and choices can change the future landscape of the Northeast and Midwest. Th e research is focused on the 20 states bounded by Maine, Maryland, Missouri and Minnesota—the most heavily forested and most densely populated quadrant of the...

Exercise Desert Rock VII. Operation Order Number 1. Army, Camp Desert Rock, Nevada

DTIC Science & Technology

1957-05-11

te locetod at the rear of the serial. Vehic ’es * td ii break down durirG the mov ant to Uhe observer area will be pushed to the side of the road ni...26th TC Bn,Hq & IHq co 2d TC Truck Co (Peo) 38th TC Co (Hv) 351st TC Co (Red) TC Provisional Aircraft Uaint Det DESE,t- ROCK PROJECTS Project 50.3

Community Air Sensor Network (CAIRSENSE) Project: Lower Cost, Continuous Ambient Monitoring Methods

EPA Pesticide Factsheets

CAIRSENSE Project presentation was given at the 108th Annual Meeting of the Air & Waste Management Associate in June 2015. The presentation provides an overview of the CAIRSENSE Project and general info about the sensors used in the CAIRSENSE Project.

An intercalated BSc degree is associated with higher marks in subsequent medical school examinations.

PubMed

Cleland, Jennifer A; Milne, Andrew; Sinclair, Hazel; Lee, Amanda J

2009-05-19

To compare medical students on a modern MBChB programme who did an optional intercalated degree with their peers who did not intercalate; in particular, to monitor performance in subsequent undergraduate degree exams. This was a retrospective, observational study of anonymised databases of medical student assessment outcomes. Data were accessed for graduates, University of Aberdeen Medical School, Scotland, UK, from the years 2003 to 2007 (n = 861). The main outcome measure was marks for summative degree assessments taken after intercalating. Of 861 medical students, 154 (17.9%) students did an intercalated degree. After adjustment for cohort, maturity, gender and baseline (3rd year) performance in matching exam type, having done an IC degree was significantly associated with attaining high (18-20) common assessment scale (CAS) marks in three of the six degree assessments occurring after the IC students rejoined the course: the 4th year written exam (p < 0.001), 4th year OSCE (p = 0.001) and the 5th year Elective project (p = 0.010). Intercalating was associated with improved performance in Years 4 and 5 of the MBChB. This improved performance will further contribute to higher academic ranking for Foundation Year posts. Long-term follow-up is required to identify if doing an optional intercalated degree as part of a modern medical degree is associated with following a career in academic medicine.

An intercalated BSc degree is associated with higher marks in subsequent medical school examinations

PubMed Central

Cleland, Jennifer A; Milne, Andrew; Sinclair, Hazel; Lee, Amanda J

2009-01-01

Background To compare medical students on a modern MBChB programme who did an optional intercalated degree with their peers who did not intercalate; in particular, to monitor performance in subsequent undergraduate degree exams. Methods This was a retrospective, observational study of anonymised databases of medical student assessment outcomes. Data were accessed for graduates, University of Aberdeen Medical School, Scotland, UK, from the years 2003 to 2007 (n = 861). The main outcome measure was marks for summative degree assessments taken after intercalating. Results Of 861 medical students, 154 (17.9%) students did an intercalated degree. After adjustment for cohort, maturity, gender and baseline (3rd year) performance in matching exam type, having done an IC degree was significantly associated with attaining high (18–20) common assessment scale (CAS) marks in three of the six degree assessments occurring after the IC students rejoined the course: the 4th year written exam (p < 0.001), 4th year OSCE (p = 0.001) and the 5th year Elective project (p = 0.010). Conclusion Intercalating was associated with improved performance in Years 4 and 5 of the MBChB. This improved performance will further contribute to higher academic ranking for Foundation Year posts. Long-term follow-up is required to identify if doing an optional intercalated degree as part of a modern medical degree is associated with following a career in academic medicine. PMID:19454007

Effects of the background electrolyte on Th(IV) sorption to muscovite mica

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmidt, Moritz; Hellebrandt, Stefan; Knope, Karah E.

2015-09-01

The adsorption of tetravalent thorium on the muscovite mica (001) basal plane was studied by X-ray crystal truncation rod (CTR), and resonant anomalous X-ray reflectivity (RAXR) measurements and alpha spectrometry in the presence of perchlorate background electrolytes LiClO 4, NaClO 4, and KClO 4 ([Th(IV)] = 0.1 mM, I = 0.1 M or 0.01 M, pH = 3.3 ± 0.3). RAXR data directly reveal a strong influence of the background electrolyte on the actinide sorption. No significant Th adsorption was observed in 0.1 M NaClO 4, i.e., the Th coverage θ(Th), the number of Th per unit cell area ofmore » the muscovite surface (A UC = 46.72 Å 2), was ≤ 0.01 Th/A UC, whereas limited uptake (θ(Th) ~ 0.04 Th/A UC) was detected at a lower ionic strength (I = 0.01 M). These results are in stark contrast to the behavior of Th in 0.1 M NaCl which showed a coverage of 0.4 Th/A UC (Schmidt et al., 2012a). Th uptake was also influenced by the electrolyte cation. Weak adsorption was observed in 0.1M KClO 4 (θ(Th) ~ 0.07 Th/AUC) similar to the results in NaClO 4 at lower ionic strength. In contrast, strong adsorption was found in 0.1 M LiClO 4, with θ(Th) = 4.9 Th/A UC, a ~10-fold increase compared with that previously reported in NaCl. These differences are confirmed independently by ex situ alpha spectrometry, which shows no measurable Th coverage in 0.1 M NaClO 4 background in contrast to a large coverage of 1.6 Th/A UC in 0.1 M LiClO 4. The CTR/RAXR analyses of Th-LiClO 4 show the sorption structure consisting of Th species that are broadly distributed, centered at heights of 4.1 Å and 29 Å distance from the interface. Neither the very large distribution height of the second species nor the high coverage can be explained with (hydrated) ionic adsorption, suggesting that the enhanced uptake is presumably due to the formation and sorption of Th nanoparticles.« less

STAT4 Deficiency Fails To Induce Lung Th2 or Th17 Immunity following Primary or Secondary Respiratory Syncytial Virus (RSV) Challenge but Enhances the Lung RSV-Specific CD8+ T Cell Immune Response to Secondary Challenge

PubMed Central

Dulek, Daniel E.; Newcomb, Dawn C.; Toki, Shinji; Goliniewska, Kasia; Cephus, Jacqueline; Reiss, Sara; Bates, John T.; Crowe, James E.; Boyd, Kelli L.; Moore, Martin L.; Zhou, Weisong

2014-01-01

ABSTRACT Immune-mediated lung injury is a hallmark of lower respiratory tract illness caused by respiratory syncytial virus (RSV). STAT4 plays a critical role in CD4+ Th1 lineage differentiation and gamma interferon (IFN-γ) protein expression by CD4+ T cells. As CD4+ Th1 differentiation is associated with negative regulation of CD4+ Th2 and Th17 differentiation, we hypothesized that RSV infection of STAT4−/− mice would result in enhanced lung Th2 and Th17 inflammation and impaired lung Th1 inflammation compared to wild-type (WT) mice. We performed primary and secondary RSV challenges in WT and STAT4−/− mice and used STAT1−/− mice as a positive control for the development of RSV-specific lung Th2 and Th17 inflammation during primary challenge. Primary RSV challenge of STAT4−/− mice resulted in decreased T-bet and IFN-γ expression levels in CD4+ T cells compared to those of WT mice. Lung Th2 and Th17 inflammation did not develop in primary RSV-challenged STAT4−/− mice. Decreased IFN-γ expression by NK cells, CD4+ T cells, and CD8+ T cells was associated with attenuated weight loss and enhanced viral clearance with primary challenge in STAT4−/− mice compared to WT mice. Following secondary challenge, WT and STAT4−/− mice also did not develop lung Th2 or Th17 inflammation. In contrast to primary challenge, secondary RSV challenge of STAT4−/− mice resulted in enhanced weight loss, an increased lung IFN-γ expression level, and an increased lung RSV-specific CD8+ T cell response compared to those of WT mice. These data demonstrate that STAT4 regulates the RSV-specific CD8+ T cell response to secondary infection but does not independently regulate lung Th2 or Th17 immune responses to RSV challenge. IMPORTANCE STAT4 is a protein critical for both innate and adaptive immune responses to viral infection. Our results show that STAT4 regulates the immune response to primary and secondary challenge with RSV but does not restrain RSV-induced lung Th2 or Th17 immune responses. These findings suggest that STAT4 expression may influence lung immunity and severity of illness following primary and secondary RSV infections. PMID:24920804

Aids to navigation service force mix 2000 project. Volume 1 : development and application of an aids to navigation service force mix decision support system

DOT National Transportation Integrated Search

1992-07-01

The Aids to Navigation (ATON) Service Force Mix (SFM) 2000 Project is documented in a Project Overview and three separately bound volumes. This is the Project Overview. The Project Overview describes the purpose, approach, analysis, and results of th...

Projections of Education Statistics to 2019. Thirty-Eighth Edition. NCES 2011-017

ERIC Educational Resources Information Center

Hussar, William J.; Bailey, Tabitha M.

2011-01-01

"Projections of Education Statistics to 2019" is the 38th report in a series begun in 1964. It includes statistics on elementary and secondary schools and degree-granting institutions. This report provides revisions of projections shown in "Projections of Education Statistics to 2018." Included are projections of enrollment,…

Projections of Education Statistics to 2020. Thirty-Ninth Edition. NCES 2011-026

ERIC Educational Resources Information Center

Hussar, William J.; Bailey, Tabitha M.

2011-01-01

"Projections of Education Statistics to 2020" is the 39th report in a series begun in 1964. It includes statistics on elementary and secondary schools and postsecondary degree-granting institutions. This report provides revisions of projections shown in "Projections of Education Statistics to 2019". Included are projections of…

Projections of Education Statistics to 2025. Forty-Fourth Edition. NCES 2017-019

ERIC Educational Resources Information Center

Hussar, William J.; Bailey, Tabitha M.

2017-01-01

"Projections of Education Statistics to 2025" is the 44th report in a series begun in 1964. It includes statistics on elementary and secondary schools and degree-granting postsecondary institutions. This report provides revisions of projections shown in Projections of Education Statistics to 2024 and projections of enrollment, graduates,…

Creating a human brain proteome atlas--14th HUPO BPP workshop September 20-21, 2010, Sydney, Australia.

PubMed

Gröttrup, Bernd; Marcus, Katrin; Grinberg, Lea T; Lee, Sang K; Meyer, Helmut E; Park, Young M

2011-08-01

The HUPO Brain Proteome Project (HUPO BPP) held its 14th workshop during the HUPO 9th Annual World Congress in Sydney, Australia. The principal aim of this project is to discover prognostic and diagnostic biomarkers associated with neurodegenerative diseases and brain aging, with the ultimate objective of obtaining a better understanding of these conditions and creating roads for the development of novel diagnostic techniques and effective treatments. The attendees came together to discuss progress in the human clinical neuroproteomics and to define the needs and guidelines required for more advanced proteomics approaches. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A Revised Estimate of 20th Century Global Mean Sea Level

NASA Astrophysics Data System (ADS)

Hay, C.; Morrow, E.; Kopp, R. E., III; Mitrovica, J. X.

2014-12-01

One of the primary goals of paleo-sea level research is to assess the stability of ice sheets and glaciers in warming climates. In this context, the 20th century may be thought of as the most recent, recorded, and studied of all past episodes of warming. Over the past decade, a consensus has emerged in the literature that 20th century global mean sea level (GMSL), inferred from tide gauge records, rose at a mean rate of 1.6-1.9 mm/yr. This sea-level rise can be attributed to multiple sources, including thermal expansion of the oceans, ice sheet and glacier mass flux, and anthropogenic changes in land water storage. The Fifth Assessment Report of the IPCC summarized the estimated contributions of these sources over 1901-1990 and computed a total rate, using a bottom-up approach, of ~1.0 mm/yr, which falls significantly short of the rate inferred from tide gauge records. Using two independent probabilistic approaches that utilize models of glacial isostatic adjustment, ocean dynamics, and the sea-level fingerprints of rapid land-ice melt to analyze tide gauge records (Kalman smoothing and Gaussian process regression), we are able to close the 20th century sea-level budget and resolve the above enigma. Our revised estimate for the rate of GMSL rise during 1901-1990 is 1.1-1.3 mm/yr (90% credible interval). This value, which is ~20-30% less than previous estimates, suggests that the change in the GMSL rate from the 20th century to the last two decades (2.7 ± 0.4 mm/yr, consistent with past estimates) was greater than previous estimates. Moreover, since some forward projections of GMSL change into the next century are based in part on past estimates of GMSL change, our revised rate may impact projections of GMSL rise for the 21st century and beyond.

GOME/ERS-2: New Homogeneous Level 1B Data from an Old Instrument

NASA Astrophysics Data System (ADS)

Slijkhuis, S.; Aberle, B.; Coldewey-Egbers, M.; Loyola, D.; Dehn, A.; Fehr, T.

2015-11-01

In the framework of ESA's "GOME Evolution Project", a reprocessing will be made of the entire 16 year GOME Level 1 dataset. The GOME Evolution Project further includes the generation of a new GOME water vapour product, and a public outreach programme.In this paper we will describe the reprocessing of the Level 1 data, carried out with the latest version of the GOME Data Processor at DLR. The change most visible to the user will be the new product format in NetCDF, plus supporting documentation (ATBD and PUM). Full-mission reprocessed L1b data are expected to be released in the 4th quarter of 2015.

The crystal chemistry of four thorium sulfates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Albrecht, Amanda J.; Sigmon, Ginger E.; Moore-Shay, Laura

2011-07-15

Four thorium sulfate compounds have been synthesized and characterized. [Th(SO{sub 4}){sub 2}(H{sub 2}O){sub 7}].2H{sub 2}O (ThS1) crystallizes in space group P2{sub 1}/m, a=7.2488(4), b=12.1798(7), c=8.0625(5) A, {beta}=98.245(1){sup o}; Na{sub 10}[Th{sub 2}(SO{sub 4}){sub 9}(H{sub 2}O){sub 2}].3H{sub 2}O (ThS2), Pna2{sub 1}, a=17.842(2), b=6.9317(8), c=27.550(3) A; Na{sub 2}[Th{sub 2}(SO{sub 4}){sub 5}(H{sub 2}O){sub 3}].H{sub 2}O (ThS3), C2/c, a=16.639(2), b=9.081(1), c=25.078(3) A, {beta}= 95.322(2){sup o}; [Th{sub 4}(SO{sub 4}){sub 7}(OH){sub 2}(H{sub 2}O){sub 6}].2H{sub 2}O (ThS4), Pnma, a=18.2127(9), b=11.1669(5), c=14.4705(7) A. In all cases the Th cations are coordinated by nine O atoms corresponding to SO{sub 4} tetrahedra, OH groups, and H{sub 2}O groups. The structural unitmore » of ThS1 is an isolated cluster consisting of a single Th polyhedron with two monodentate SO{sub 4} tetrahedra and seven H{sub 2}O groups. A double-wide Th sulfate chain is the basis of ThS2. The structures of ThS3 and ThS4 are frameworks of Th polyhedra and sulfate tetrahedra, and each contains channels that extend through the framework. One of the Th cations in ThS3 is coordinated by a bidentate SO{sub 4} tetrahedron, and ThS4 is unusual in the presence of a pair of Th cations that share a polyhedral face. - Graphical abstract: The structures of four hydrous thorium sulfates are reported that have structural units consisting of finite clusters, chains, and frameworks. Highlights: > Four hydrous thorium sulfates have structural units consisting of finite clusters, chains, and frameworks. > In each the Th cations are coordinated by nine O atoms from SO{sub 4} tetrahedra, OH groups, and H{sub 2}O groups. > The details of the linkages of ThO{sub 9} polyhedra and sulfate tetrahedra vary considerably in these structures.« less

Communicating Science to Impact Learning? A Phenomenological Inquiry into 4th and 5th Graders' Perceptions of Science Information Sources

NASA Astrophysics Data System (ADS)

Gelmez Burakgazi, Sevinc; Yildirim, Ali; Weeth Feinstein, Noah

2016-04-01

Rooted in science education and science communication studies, this study examines 4th and 5th grade students' perceptions of science information sources (SIS) and their use in communicating science to students. It combines situated learning theory with uses and gratifications theory in a qualitative phenomenological analysis. Data were gathered through classroom observations and interviews in four Turkish elementary schools. Focus group interviews with 47 students and individual interviews with 17 teachers and 10 parents were conducted. Participants identified a wide range of SIS, including TV, magazines, newspapers, internet, peers, teachers, families, science centers/museums, science exhibitions, textbooks, science books, and science camps. Students reported using various SIS in school-based and non-school contexts to satisfy their cognitive, affective, personal, and social integrative needs. SIS were used for science courses, homework/project assignments, examination/test preparations, and individual science-related research. Students assessed SIS in terms of the perceived accessibility of the sources, the quality of the content, and the content presentation. In particular, some sources such as teachers, families, TV, science magazines, textbooks, and science centers/museums ("directive sources") predictably led students to other sources such as teachers, families, internet, and science books ("directed sources"). A small number of sources crossed context boundaries, being useful in both school and out. Results shed light on the connection between science education and science communication in terms of promoting science learning.

Protein Markers of Neurotransmitter Synthesis and Release in Postmortem Schizophrenia Substantia Nigra.

PubMed

Schoonover, Kirsten E; McCollum, Lesley A; Roberts, Rosalinda C

2017-01-01

The substantia nigra (SN) provides the largest dopaminergic input to the brain, projects to the striatum (the primary locus of action for antipsychotic medication), and receives GABAergic and glutamatergic inputs. This study used western blot analysis to compare protein levels of tyrosine hydroxylase (TH), glutamate decarboxylase (GAD67), and vesicular glutamate transporters (vGLUT1 and vGLUT2) in postmortem human SN in schizophrenia subjects (n=13) and matched controls (n=12). As a preliminary analysis, the schizophrenia group was subdivided by (1) treatment status: off medication (n=4) or on medication (n=9); or (2) treatment response: treatment resistant (n=5) or treatment responsive (n=4). The combined schizophrenia group had higher TH and GAD67 protein levels than controls (an increase of 69.6%, P=0.01 and 19.5%, P=0.004, respectively). When subdivided by medication status, these increases were found in the on-medication subjects (TH 88.3%, P=0.008; GAD67 40.6%, P=0.003). In contrast, unmedicated schizophrenia subjects had higher vGLUT2 levels than controls (an increase of 28.7%, P=0.041), but vGLUT2 levels were similar between medicated schizophrenia subjects and controls. Treatment-resistant subjects had significantly higher TH and GAD67 levels than controls (an increase of 121.0%, P=0.0003 and 58.7%, P=0.004, respectively). These data suggest increases in dopamine and GABA transmission in the SN in schizophrenia, with a potential relation to treatment and response.

Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation

PubMed Central

Zhang, Song; Takaku, Motoki; Zou, Liyun; Gu, Ai-di; Chou, Wei-chun; Zhang, Ge; Wu, Bing; Kong, Qing; Thomas, Seddon Y.; Serody, Jonathan S.; Chen, Xian; Xu, Xiaojiang; Wade, Paul A.; Cook, Donald N.; Ting, Jenny P.; Wan, Yisong Y.

2017-01-01

Th17 cells are critically involved in host defense, inflammation, and autoimmunity1–5. TGF-β is instrumental in Th17 differentiation by cooperating with IL-66,7. Yet, the mechanism of how TGF-β enables Th17 differentiation remains elusive. Here we reveal that TGF-β licenses Th17 differentiation by releasing Ski-Smad4-complex suppressed RORγt expression. We found serendipitously that, unlike wild-type T cells, Smad4-deficient T cells differentiated into Th17 cells in the absence of TGF-β signaling in a RORγt-dependent manner. Ectopic Smad4 expression suppressed the RORγt expression and Th17 differentiation of Smad4-deficient T cells. Unexpectedly however, TGF-β neutralized Smad4 mediated suppression without affecting Smad4 binding to Rorc locus. Proteomic analysis revealed that Smad4 interacted with Ski, a transcriptional repressor degraded upon TGF-β stimulation. Ski controlled the histone acetylation/de-acetylation of Rorc locus and Th17 differentiation via Smad4 because ectopic Ski expression inhibited H3K9Ac of Rorc locus, Rorc expression and Th17 differentiation in a Smad4-dependent manner. Therefore, TGF-β-induced disruption of Ski releases Ski-Smad4 complex imposed suppression of RORγt to license Th17 differentiation. This study reveals a critical mechanism by which TGF-β controls Th17 differentiation and uncovers Ski-Smad4 axis as a potential therapeutic target for treating Th17 related diseases. PMID:29072299

Proceedings of the Annual National Conference on ADA Technology (9th) Held in Washington, DC on 4-7 March 1991

DTIC Science & Technology

1991-03-07

rsolve the attack; delay whil the weapon has to wait; RESOURCE ALLOCATION . PRIORITY OF signal readiness to CONTROL; TARGETS. AND BIAS OF THE SYSTEM...Communications Systems. focal point for Computer Resource He served as project manager for the Management (CRM), Advanced Software development of the Joint...Interface Test Technology (AST), Ada Technology, Systems (JITS) - the world’s largest Joint/Army Interoperability Testing distributed command and

Proceedings of the Systems Reengineering Technology Workshop (4th) held in Monterey, California on February 8 - 10, 1994

DTIC Science & Technology

1994-09-01

report for the Properties of User Interface Software Architetures ", draft DISCUS Working Group, Programmers Tutorial, MITRE paper, SEI. Carnegie...execution that we have defined called asynchronous remote procedure call (ARPC) [15], which allows concurrency in amounts proportional to the amount of...demonstration project to use STARS DoD software budget and the proportion concepts. IBM is one of the prime is expected to be increased during the contractors

Designing Networks that are Capable of Self-Healing and Adapting

DTIC Science & Technology

2017-04-01

Undergrad. Res. Fellowship, visiting from Caltech. Undergraduate Eugene Park Math Duke Models of self-healing networks (undergrad. senior thesis...Graduate student Anastasia Deckard Math Duke 3rd/4th year PhD. Wrote software for simulation. Undergraduate Nick Day Math LIMS Summer project at...Harer gave a talk on this DTRA grant to undergraduate math majors at Duke. 11 Q UA D C HA R T Uploaded to the DTRA Basic and Fundamental Research

Environmental Assessment for Capital Improvement Projects, Buckley Air Force Base, Colorado. Volume 2 of 2

DTIC Science & Technology

2006-03-01

2003 Air Emission Inventory, July 2004. o The generators are assumed to be diesel-fired and have a horsepower rating of less than 600 hp. o...In July 2003, the 460th LRS purchased and installed an automated movable storage system for mobility bag storage. This system eliminates wasted aisle...Installation Restoration Program Draft Final Engineering Evaluation/Cost Analysis IRP Site 4. July . • URS Corporation (URS). 2003a. Buckley Air Force

Analysis of Air Force Secondary Power Logistics Solution Contract

DTIC Science & Technology

2010-05-21

IL 62225 SUBJECT: Audit. Analysis of Air Force Secondary Power Logistics Solution Contract, 748th Supply Chain Management Group, Hill Air Fon:r... Power Logis.tics Solution Contnict. 748111 Supply Ch.,in Management Group. !-lill Air FOfC! BII.SI!, UT (Project 02009· DOOOCH·0213.000) I. AUlIctlcd...00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE Analysis of Air Force Secondary Power Logistics Solution Contract 5a. CONTRACT NUMBER 5b. GRANT

Correspondence Search Mitigation Using Feature Space Anti-Aliasing

DTIC Science & Technology

2007-01-01

trackers are widely used in astro -inertial nav- igation systems for long-range aircraft, space navigation, and ICBM guidance. When ground images are to be...frequency domain representation of the point spread function, H( fx , fy), is called the optical transfer function. Applying the Fourier transform to the...frequency domain representation of the image: I( fx , fy, t) = O( fx , fy, t)H( fx , fy) (4) In most conditions, the projected scene can be treated as a

On Generalizations of Cochran’s Theorem and Projection Matrices.

DTIC Science & Technology

1980-08-01

Definiteness of the Estimated Dispersion Matrix in a Multivariate Linear Model ," F. Pukelsheim and George P.H. Styan, May 1978. TECHNICAL REPORTS...with applications to the analysis of covariance," Proc. Cambridge Philos. Soc., 30, pp. 178-191. Graybill , F. A. and Marsaglia, G. (1957...34Idempotent matrices and quad- ratic forms in the general linear hypothesis," Ann. Math. Statist., 28, pp. 678-686. Greub, W. (1975). Linear Algebra (4th ed

Improving Large Cetacean Implantable Satellite Tag Designs to Maximize Tag Robustness and Minimize Health Effects to Individual Animals

DTIC Science & Technology

2015-09-30

Olympia, WA, 98501 & National Marine Mammal Laboratory Alaska Fisheries Science Center, NOAA Fisheries 7600 Sand Point Way NE Seattle, WA...to Maximize Tag Robustness and Minimize Health Effects to Individual Animals Alexandre N. Zerbini Cascadia Research Collective 218 ½ 4 th Ave W...available to the marine mammal community after the conclusion of the project. This study has been carried out by scientists and engineers from eight

Coping with Higher Sea Levels and Increased Coastal Flooding in New York City. Chapter 13

NASA Technical Reports Server (NTRS)

Gornitz, Vivien; Horton, Radley; Bader, Daniel A.; Orton, Philip; Rosenzweig, Cynthia

2017-01-01

The 837 km New York City shoreline is lined by significant economic assets and dense population vulnerable to sea level rise and coastal flooding. After Hurricane Sandy in 2012, New York City developed a comprehensive plan to mitigate future climate risks, drawing upon the scientific expertise of the New York City Panel on Climate Change (NPCC), a special advisory group comprised of university and private-sector experts. This paper highlights current NPCC findings regarding sea level rise and coastal flooding, with some of the City's ongoing and planned responses. Twentieth century sea level rise in New York City (2.8 cm/decade) exceeded the global average (1.7 cm/decade), underscoring the enhanced regional risk to coastal hazards. NPCC (2015) projects future sea level rise at the Battery of 28 - 53 cm by the 2050s and 46 - 99 cm by the 2080s, relative to 2000 - 2004 (mid-range, 25th - 75th percentile). High-end SLR estimates (90th percentile) reach 76 cm by the 2050s, and 1.9 m by 2100. Combining these projections with updated FEMA flood return period curves, assuming static flood dynamics and storm behavior, flood heights for the 100-year storm (excluding waves) attain 3.9-4.5 m (mid-range), relative to the NAVD88 tidal datum, and 4.9 m (high end) by the 2080s, up from 3.4 m in the 2000s. Flood heights with a 1% annual chance of occurrence in the 2000s increase to 2.0 - 5.4% (mid-range) and 12.7% per year (high-end), by the 2080s. Guided by NPCC (2013, 2015) findings, New York City has embarked on a suite of initiatives to strengthen coastal defenses, employing various approaches tailored to specific neighborhood needs. NPCC continues its collaboration with the city to investigate vulnerability to extreme climate events, including heat waves, inland floods and coastal storms. Current research entails higher-resolution neighborhood-level coastal flood mapping, changes in storm characteristics, surge height interactions with sea level rise, and stronger engagement with stakeholders and community-based organizations.

Robotic Lunar Lander Development Project Status

NASA Technical Reports Server (NTRS)

Hammond, Monica; Bassler, Julie; Morse, Brian

2010-01-01

This slide presentation reviews the status of the development of a robotic lunar lander. The goal of the project is to perform engineering tests and risk reduction activities to support the development of a small lunar lander for lunar surface science. This includes: (1) risk reduction for the flight of the robotic lander, (i.e., testing and analyzing various phase of the project); (2) the incremental development for the design of the robotic lander, which is to demonstrate autonomous, controlled descent and landing on airless bodies, and design of thruster configuration for 1/6th of the gravity of earth; (3) cold gas test article in flight demonstration testing; (4) warm gas testing of the robotic lander design; (5) develop and test landing algorithms; (6) validate the algorithms through analysis and test; and (7) tests of the flight propulsion system.

Low-cost solar array project and Proceedings of the 15th Project Integration Meeting

NASA Technical Reports Server (NTRS)

1980-01-01

Progress made by the Low-Cost Solar Array Project during the period December 1979 to April 1980 is described. Project analysis and integration, technology development in silicon material, large area silicon sheet and encapsulation, production process and equipment development, engineering, and operation are included.

Activation of CH4 by Th(+) as studied by guided ion beam mass spectrometry and quantum chemistry.

PubMed

Cox, Richard M; Armentrout, P B; de Jong, Wibe A

2015-04-06

The reaction of atomic thorium cations with CH4 (CD4) and the collision-induced dissociation (CID) of ThCH4(+) with Xe are studied using guided ion beam tandem mass spectrometry. In the methane reactions at low energies, ThCH2(+) (ThCD2(+)) is the only product; however, the energy dependence of the cross-section is inconsistent with a barrierless exothermic reaction as previously assumed on the basis of ion cyclotron resonance mass spectrometry results. The dominant product at higher energies is ThH(+) (ThD(+)), with ThCH3(+) (ThCD3(+)) having a similar threshold energy. The latter product subsequently decomposes at still higher energies to ThCH(+) (ThCD(+)). CID of ThCH4(+) yields atomic Th(+) as the exclusive product. The cross-sections of all product ions are modeled to provide 0 K bond dissociation energies (in eV) of D0(Th(+)-H) ≥ 2.25 ± 0.18, D0(Th(+)-CH) = 6.19 ± 0.16, D0(Th(+)-CH2) ≥ 4.54 ± 0.09, D0(Th(+)-CH3) = 2.60 ± 0.30, and D0(Th(+)-CH4) = 0.47 ± 0.05. Quantum chemical calculations at several levels of theory are used to explore the potential energy surfaces for activation of methane by Th(+), and the effects of spin-orbit coupling are carefully considered. When spin-orbit coupling is explicitly considered, a barrier for C-H bond activation that is consistent with the threshold measured for ThCH2(+) formation (0.17 ± 0.02 eV) is found at all levels of theory, whereas this barrier is observed only at the BHLYP and CCSD(T) levels otherwise. The observation that the CID of the ThCH4(+) complex produces Th(+) as the only product with a threshold of 0.47 eV indicates that this species has a Th(+)(CH4) structure, which is also consistent with a barrier for C-H bond activation. This barrier is thought to exist as a result of the mixed ((4)F,(2)D) electronic character of the Th(+) J = (3)/2 ground level combined with extensive spin-orbit effects.

Shifting Engagements in Figured Worlds: Middle School Mathematics Students' Participation in an Architectural Design Project

ERIC Educational Resources Information Center

Jurow, A. Susan

2005-01-01

Project-based curricula have the potential to engage students' interests. But how do students become interested in the goals of a project? This article documents how a group of 8th-grade students participated in an architectural design project called the Antarctica Project. The project is based on the imaginary premise that students need to design…

Role of distinct CD4(+) T helper subset in pathogenesis of oral lichen planus.

PubMed

Wang, Hui; Zhang, Dunfang; Han, Qi; Zhao, Xin; Zeng, Xin; Xu, Yi; Sun, Zheng; Chen, Qianming

2016-07-01

Oral lichen planus (OLP) is one of the most common chronic inflammatory oral mucosal diseases with T-cell-mediated immune pathogenesis. In subepithelial and lamina propria of OLP local lesions, the presence of CD4(+) T helper (CD4(+) Th) cells appeared as the major lymphocytes. These CD4(+) T lymphocytes can differentiate into distinct Th cell types such as Th1, Th2, Treg, Th17, Th22, Th9, and Tfh within the context of certain cytokines environment. Growing evidence indicated that Th1/Th2 imbalance may greatly participate into the cytokine network of OLP immunopathology. In addition, Th1/Th2 imbalance can be regulated by the Treg subset and also greatly influenced by the emerging novel CD4(+) Th subset Th17. Furthermore, the presence of novel subsets Th22, Th9 and Tfh in OLP patients is yet to be clarified. All these Th subsets and their specific cytokines may play a critical role in determining the character, extent and duration of immune responses in OLP pathogenesis. Therefore, we review the roles of distinct CD4(+) Th subsets and their signature cytokines in determining disease severity and susceptibility of OLP and also reveal the novel therapeutic strategies based on T lymphocytes subsets in OLP treatment. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Trapping of Li(+) Ions by [ThFn](4-n) Clusters Leading to Oscillating Maxwell-Stefan Diffusivity in the Molten Salt LiF-ThF4.

PubMed

Chakraborty, Brahmananda; Kidwai, Sharif; Ramaniah, Lavanya M

2016-08-18

A molten salt mixture of lithium fluoride and thorium fluoride (LiF-ThF4) serves as a fuel as well as a coolant in the most sophisticated molten salt reactor (MSR). Here, we report for the first time dynamic correlations, Onsager coefficients, Maxwell-Stefan (MS) diffusivities, and the concentration dependence of density and enthalpy of the molten salt mixture LiF-ThF4 at 1200 K in the composition range of 2-45% ThF4 and also at eutectic composition in the temperature range of 1123-1600 K using Green-Kubo formalism and equilibrium molecular dynamics simulations. We have observed an interesting oscillating pattern for the MS diffusivity for the cation-cation pair, in which ĐLi-Th oscillates between positive and negative values with the amplitude of the oscillation reducing as the system becomes rich in ThF4. Through the velocity autocorrelation function, vibrational density of states, radial distribution function analysis, and structural snapshots, we establish an interplay between the local structure and multicomponent dynamics and predict that formation of negatively charged [ThFn](4-n) clusters at a higher ThF4 mole % makes positively charged Li(+) ions oscillate between different clusters, with their range of motion reducing as the number of [ThFn](4-n) clusters increases, and finally Li(+) ions almost get trapped at a higher ThF4% when the electrostatic force on Li(+) exerted by various surrounding clusters gets balanced. Although reports on variations of density and enthalpy with temperature exist in the literature, for the first time we report variations of the density and enthalpy of LiF-ThF4 with the concentration of ThF4 (mole %) and fit them with the square root function of ThF4 concentration, which will be very useful for experimentalists to obtain data over a range of concentrations from fitting the formula for design purposes. The formation of [ThFn](4-n) clusters and the reduction in the diffusivity of the ions at a higher ThF4% may limit the percentage of ThF4 that can be used in the MSR to optimize the neutron economy.

76 FR 37649 - Safety Zone; Northern California Annual Fireworks Events, July 4th Fireworks Display

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-28

... Zone; Northern California Annual Fireworks Events, July 4th Fireworks Display AGENCY: Coast Guard, DHS... annual July 4th Fireworks Display (Tahoe City 4th of July Fireworks Display). This action is necessary to... INFORMATION: The Coast Guard will enforce the safety zone for the annual Tahoe City 4th of July Fireworks in...

A novel acute HIV infection staging system based on 4th generation immunoassay.

PubMed

Ananworanich, Jintanat; Fletcher, James L K; Pinyakorn, Suteeraporn; van Griensven, Frits; Vandergeeten, Claire; Schuetz, Alexandra; Pankam, Tippawan; Trichavaroj, Rapee; Akapirat, Siriwat; Chomchey, Nitiya; Phanuphak, Praphan; Chomont, Nicolas; Michael, Nelson L; Kim, Jerome H; de Souza, Mark

2013-05-29

Fourth generation (4thG) immunoassay (IA) is becoming the standard HIV screening method but was not available when the Fiebig acute HIV infection (AHI) staging system was proposed. Here we evaluated AHI staging based on a 4thG IA (4thG staging). Screening for AHI was performed in real-time by pooled nucleic acid testing (NAT, n=48,828 samples) and sequential enzyme immunoassay (EIA, n=3,939 samples) identifying 63 subjects with non-reactive 2nd generation EIA (Fiebig stages I (n=25), II (n=7), III (n=29), IV (n=2)). The majority of samples tested (n=53) were subtype CRF_01AE (77%). NAT+ subjects were re-staged into three 4thG stages: stage 1 (n=20; 4th gen EIA-, 3rd gen EIA-), stage 2 (n=12; 4th gen EIA+, 3rd gen EIA-), stage 3 (n=31; 4th gen EIA+, 3rd gen EIA+, Western blot-/indeterminate). 4thG staging distinguishes groups of AHI subjects by time since presumed HIV exposure, pattern of CD8+ T, B and natural killer cell absolute numbers, and HIV RNA and DNA levels. This staging system further stratified Fiebig I subjects: 18 subjects in 4thG stage 1 had lower HIV RNA and DNA levels than 7 subjects in 4thG stage 2. Using 4th generation IA as part of AHI staging distinguishes groups of patients by time since exposure to HIV, lymphocyte numbers and HIV viral burden. It identifies two groups of Fiebig stage I subjects who display different levels of HIV RNA and DNA, which may have implication for HIV cure. 4th generation IA should be incorporated into AHI staging systems.

Development and Evaluation of an Experimental Curriculum for the New Quincy (Mass.) Vocational-Technical School. The Science Curriculum.

ERIC Educational Resources Information Center

Champagne, Audrey; Albert, Anne

Activities concerning the development of the science curriculum of Project ABLE are summarized. The science curriculum attempts to relate science content to vocational areas where applicable, but emphasizes generalizations which the student will apply in his specific vocational field. Intended for 10th, 11th, and 12th grade students, the…

Dust-enshrouded asymptotic giant branch stars in the solar neighborhood

NASA Technical Reports Server (NTRS)

Jura, M.; Kleinmann, S. G.

1989-01-01

Using available infrared catalogs, an inventory is taken of the AGB star losing large amounts of mass within about 1 kpc of the sun. A surface density of these stars is estimated of about 25/sq kpc projected onto the plane of the Galaxy. Of these stars, about one-half are oxygen-rich while the other half are carbon-rich. The total mass-loss rate from AGB stars into the interstellar medium is probably between 3 and 6 x 10 to the -4th solar mass/sq kpc/yr. Within the uncertainties, this is in reasonable agreement with an estimated net loss rate of about 8 x 10 to the -4th solar mass/sq kpc/yr for main-sequence stars with initial masses between 1 and 5 solar masses as they evolve to white dwarfs. However, it is possible that there are important sources of mass loss which have not yet been identified. In the solar neighborhood, about one-half of all about 1.2 solar mass main-sequence stars spend greater than 30,000 yr in a carbon-star phase where they lose 1-2 x 10 to the -5th solar mass/yr and then become white dwarfs with about 0.7 solar mass.

WE-G-207-06: 3D Fluoroscopic Image Generation From Patient-Specific 4DCBCT-Based Motion Models Derived From Physical Phantom and Clinical Patient Images

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dhou, S; Cai, W; Hurwitz, M

2015-06-15

Purpose: Respiratory-correlated cone-beam CT (4DCBCT) images acquired immediately prior to treatment have the potential to represent patient motion patterns and anatomy during treatment, including both intra- and inter-fractional changes. We develop a method to generate patient-specific motion models based on 4DCBCT images acquired with existing clinical equipment and used to generate time varying volumetric images (3D fluoroscopic images) representing motion during treatment delivery. Methods: Motion models are derived by deformably registering each 4DCBCT phase to a reference phase, and performing principal component analysis (PCA) on the resulting displacement vector fields. 3D fluoroscopic images are estimated by optimizing the resulting PCAmore » coefficients iteratively through comparison of the cone-beam projections simulating kV treatment imaging and digitally reconstructed radiographs generated from the motion model. Patient and physical phantom datasets are used to evaluate the method in terms of tumor localization error compared to manually defined ground truth positions. Results: 4DCBCT-based motion models were derived and used to generate 3D fluoroscopic images at treatment time. For the patient datasets, the average tumor localization error and the 95th percentile were 1.57 and 3.13 respectively in subsets of four patient datasets. For the physical phantom datasets, the average tumor localization error and the 95th percentile were 1.14 and 2.78 respectively in two datasets. 4DCBCT motion models are shown to perform well in the context of generating 3D fluoroscopic images due to their ability to reproduce anatomical changes at treatment time. Conclusion: This study showed the feasibility of deriving 4DCBCT-based motion models and using them to generate 3D fluoroscopic images at treatment time in real clinical settings. 4DCBCT-based motion models were found to account for the 3D non-rigid motion of the patient anatomy during treatment and have the potential to localize tumor and other patient anatomical structures at treatment time even when inter-fractional changes occur. This project was supported, in part, through a Master Research Agreement with Varian Medical Systems, Inc., Palo Alto, CA. The project was also supported, in part, by Award Number R21CA156068 from the National Cancer Institute.« less

Fifth Single-Shell Tank Integrity Project Expert Panel Meeting August 28-29, 2014

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martin, Todd M.; Gunter, Jason R.; Boomer, Kayle D.

On August 28th and 29th, 2014 the Single-Shell Tank Integrity Project (SSTIP) Expert Panel (Panel) convened in Richland, Washington. This was the Panel’s first meeting since 2011 and, as a result, was focused primarily on updating the Panel on progress in response to the past recommendations (Single-Shell Tank Integrity Expert Panel Report, RPP-RPT-45921, Rev 0, May 2010). This letter documents the Panel’s discussions and feedback on Phase I activities and results.

Documentation of Assessment Instrumentation--The NORC/CRESST 12th Grade Science Assessment, Item Databases, and Test Booklets. Project 2.6: Analytic Models To Monitor Status & Progress of Learning & Performance & Their Antecedents: The School Science Assessment Project.

ERIC Educational Resources Information Center

Bock, H. Darrell

The hardware and software system used to create the National Opinion Research Center/Center for Research on Evaluation, Standards, and Student Testing (NORC/CRESST) item databases and test booklets for the 12th-grade science assessment are described. A general description of the capabilities of the system is given, with some specific information…

Research Directions in Database Security, II

DTIC Science & Technology

1990-11-01

WILLIAMS Burke Ct 286 WOLCOTT 9th Rd 795 WOOD 25th St 520 YANCEY Motley St 398 ZUZACK Arden Rd LDV> : The style of the prototype is such that the...WOLCOTT Fin Clk YANCEY Dept Mgr ZUZACK Proc Anal LDV> ;RR3: S (sortrel (project (njoin (project employee-base ’(Department Employee-Name Employee-Num...Proc Anal PROC MAHONEY Secy PROC YANCEY Dept Mgr PROC ZUZACK Proc Anal SEC BRIMER DMSO SEC FALBO Secy SEC HILL Dept Mgr SEC MITCHELL Ast DBSO SEC THOMAS

S'COOL Takes Students to New Heights

NASA Technical Reports Server (NTRS)

Green, Carolyn J.; Chambers, Lin H.

1998-01-01

Students Cloud Observations On-Line (S'COOL) is a hands-on educational project which supports NASA's Clouds and the Earth s Radiant Energy System (CERES) satellite instrument; part of the Earth Science Enterprise studying our planet. S'COOL meets science, math, technology and geography Standards of Learning (SOLs) as students observe clouds and related weather conditions, compute data and locate vital information while obtaining ground truth observations for the CERES instrument. These observations can then be used to help validate the CERES measurements; particularly detection of clear sky from space. Participants to date have been in 20 states and 5 countries and have reported great interest and learning among their students. Many have used this project as a stepping stone to further learning in other areas of Earth Science; and to do more with the Internet in the classroom. Satellite images and clues to their interpretation are used on the website ( http://asd-www.larc.nasa.gov/SCOOL/) . Background information is also given on Earth's Radiation Budget and it s importance in understanding our climate. Students can retrieve both their observations and the corresponding satellite data and participate in the validation efforts. A number of suggestions for studies to be done with the data, and related lesson plans, are available. Teachers can tailor this project to the appropriate level and subject matter needed for their students. The recommended grade level is 4th through 12th grade. The project is now open to new participants. We particularly seek schools in more remote areas, to obtain wider geographic coverage for ground truth data; so the project has been designed to use, but not require, computer technology. AGU participants attending the S'COOL presentation will be given a handout describing the project. Material for introducing the project in the classroom will be demonstrated in a participatory style.

Cost Management in a Tactical Environment: A Case Study of the 316th Expeditionary Support Command (ESC) in Iraq, 2007-2008

DTIC Science & Technology

2010-06-01

NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT Cost Management in a Tactical Environment: A Case Study of...SUBTITLE Cost Management in a Tactical Environment: A Case Study of the 316th Expeditionary Support Command (ESC) in Iraq, 2007–2008 6. AUTHOR(S...This project provides a case study of the 316th ESC, which may begin to fill that void. The 316th ESC’s staff forecasted future consumption

26 CFR 1.6073-4 - Extension of time for filing declarations by individuals.

Code of Federal Regulations, 2011 CFR

2011-04-01

... the 15th day of the 4th month of his taxable year, an extension of time for filing his declaration of estimated tax otherwise due on or before the 15th day of the 4th month of the taxable year is granted to and... States and Puerto Rico on the 15th day of the 4th month of a taxable year beginning after December 31...

26 CFR 1.6073-4 - Extension of time for filing declarations by individuals.

Code of Federal Regulations, 2014 CFR

2014-04-01

... the 15th day of the 4th month of his taxable year, an extension of time for filing his declaration of estimated tax otherwise due on or before the 15th day of the 4th month of the taxable year is granted to and... States and Puerto Rico on the 15th day of the 4th month of a taxable year beginning after December 31...

26 CFR 1.6073-4 - Extension of time for filing declarations by individuals.

Code of Federal Regulations, 2013 CFR

2013-04-01

... the 15th day of the 4th month of his taxable year, an extension of time for filing his declaration of estimated tax otherwise due on or before the 15th day of the 4th month of the taxable year is granted to and... States and Puerto Rico on the 15th day of the 4th month of a taxable year beginning after December 31...

26 CFR 1.6073-4 - Extension of time for filing declarations by individuals.

Code of Federal Regulations, 2012 CFR

2012-04-01

... the 15th day of the 4th month of his taxable year, an extension of time for filing his declaration of estimated tax otherwise due on or before the 15th day of the 4th month of the taxable year is granted to and... States and Puerto Rico on the 15th day of the 4th month of a taxable year beginning after December 31...

Identity and Diversity of Human Peripheral Th and T Regulatory Cells Defined by Single-Cell Mass Cytometry.

PubMed

Kunicki, Matthew A; Amaya Hernandez, Laura C; Davis, Kara L; Bacchetta, Rosa; Roncarolo, Maria-Grazia

2018-01-01

Human CD3 + CD4 + Th cells, FOXP3 + T regulatory (Treg) cells, and T regulatory type 1 (Tr1) cells are essential for ensuring peripheral immune response and tolerance, but the diversity of Th, Treg, and Tr1 cell subsets has not been fully characterized. Independent functional characterization of human Th1, Th2, Th17, T follicular helper (Tfh), Treg, and Tr1 cells has helped to define unique surface molecules, transcription factors, and signaling profiles for each subset. However, the adequacy of these markers to recapitulate the whole CD3 + CD4 + T cell compartment remains questionable. In this study, we examined CD3 + CD4 + T cell populations by single-cell mass cytometry. We characterize the CD3 + CD4 + Th, Treg, and Tr1 cell populations simultaneously across 23 memory T cell-associated surface and intracellular molecules. High-dimensional analysis identified several new subsets, in addition to the already defined CD3 + CD4 + Th, Treg, and Tr1 cell populations, for a total of 11 Th cell, 4 Treg, and 1 Tr1 cell subsets. Some of these subsets share markers previously thought to be selective for Treg, Th1, Th2, Th17, and Tfh cells, including CD194 (CCR4) + FOXP3 + Treg and CD183 (CXCR3) + T-bet + Th17 cell subsets. Unsupervised clustering displayed a phenotypic organization of CD3 + CD4 + T cells that confirmed their diversity but showed interrelation between the different subsets, including similarity between Th1-Th2-Tfh cell populations and Th17 cells, as well as similarity of Th2 cells with Treg cells. In conclusion, the use of single-cell mass cytometry provides a systems-level characterization of CD3 + CD4 + T cells in healthy human blood, which represents an important baseline reference to investigate abnormalities of different subsets in immune-mediated pathologies. Copyright © 2017 by The American Association of Immunologists, Inc.

Kinetics of Cathode Processes in Separation of Thorium from Molten Salts. Part I. Investigation of ThF$sub 4$ and ThF$sub 4$-CaF$sub 2$; KINETYKA PROCESU KATODOWEGO PRZY OSADZANIU TORU ZE STOPIONYCH SOLI. CZESC I. BADANIA ThF$sub 4$ I ThF$sub 4$-CaF$sub 2$

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mints, S.; Rafal'skii, V.

1961-09-01

The current-intensity curves of non-electrolyzed salts and the curves of time-intensity and current-intensity in electrolyzed salts were plotted for molten ThF/sub 4/ and ThF /sub 4/CaF/sub 2/. The intensity of salt disintegration was determined, and electric conductivity in electrolyte was observed. (trauth)

Final Technical Report for Collaborative Research: Developing and Implementing Ocean-Atmosphere Reanalyses for Climate Applications (OARCA)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Compo, Gilbert P

As an important step toward a coupled data assimilation system for generating reanalysis fields needed to assess climate model projections, the Ocean Atmosphere Coupled Reanalysis for Climate Applications (OARCA) project assesses and improves the longest reanalyses currently available of the atmosphere and ocean: the 20th Century Reanalysis Project (20CR) and the Simple Ocean Data Assimilation with sparse observational input (SODAsi) system, respectively. In this project, we make off-line but coordinated improvements in the 20CR and SODAsi datasets, with improvements in one feeding into improvements of the other through an iterative generation of new versions. These datasets now span from themore » 19th to 21st centuries. We then study the extreme weather and variability from days to decades of the resulting datasets. A total of 24 publications have been produced in this project.« less

Chemical and structural evolution in the Th-SeO3(2-)/SeO4(2-) system: from simple selenites to cluster-based selenate compounds.

PubMed

Xiao, Bin; Langer, Eike; Dellen, Jakob; Schlenz, Hartmut; Bosbach, Dirk; Suleimanov, Evgeny V; Alekseev, Evgeny V

2015-03-16

While extensive success has been gained in the structural chemistry of the U-Se system, the synthesis and characterization of Th-based Se structures are widely unexplored. Here, four new Th-Se compounds, α-Th(SeO3)2, β-Th(SeO3)2, Th(Se2O5)2, and Th3O2(OH)2(SeO4)3, have been obtained from mild hydrothermal or low-temperature (180-220 °C) flux conditions and were subsequently structurally and spectroscopically characterized. The crystal structures of α-Th(SeO3)2 and β-Th(SeO3)2 are based on ThO8 and SeO3 polyhedra, respectively, featuring a three-dimensional (3D) network with selenite anions filling in the Th channels along the a axis. Th(Se2O5)2 is a 3D framework composed of isolated ThO8 polyhedra interconnected by [Se2O5](2-) dimers. Th3O2(OH)2(SeO4)3 is also a 3D framework constructed by octahedral hexathorium clusters [Th6(μ3-O)4(μ3-OH)4](12+), which are interlinked by selenate groups SeO4(2-). The positions of the vibrational modes associated with both Se(IV)O3(2-) and Se(VI)O4(2-) units, respectively, were determined for four compounds, and the Raman spectra of α- and β-Th(SeO3)2 are compared and discussed in detail.

Status Report of Environmental Evaluations Trinity River Project, Texas. Main Text

DTIC Science & Technology

1975-06-01

metropolitan character . Portions of this subregion are shown in Photographs 17 through 22, Appendix A. 2-43 SI : -. 91 .. 3Ec 7ItZ -~g -12 - 0M 0 -.z * 4 z~ si ...rather narrow, or oceanic, aeair thC Cz_9t- h, t are wide, or continental in character , in the interior of the Basin. 1-20 1.08.06 Winds. The prevailing...3 IF cr :rr 1-68 ’-410 0 .0 0% .1^ qC) 71t 1~ *C14 II 8.- x jf 0 > I C- 0 1 ~~u~W I-4 SI IC’m LA0 0 -C >-0 r4~ __ _ _ _ __ _ _ _ _ __ _ _ _ _ V) P

Flat Plate Solar Array Project: Proceedings of the 20th Project Integration Meeting

NASA Technical Reports Server (NTRS)

Mcdonald, R. R.

1982-01-01

Progress made by the Flat-Plate Solar Array Project during the period November 1981 to April 1982 is reported. Project analysis and integration, technology research in silicon material, large-area silicon sheet and environmental isolation, cell and module formation, engineering sciences, and module performance and failure analysis are covered.

Projections of Education Statistics to 2018. Thirty-Seventh Edition. NCES 2009-062

ERIC Educational Resources Information Center

Hussar, William J.; Bailey, Tabitha M.

2009-01-01

"Projections of Education Statistics to 2018" is the 37th report in a series begun in 1964. It includes statistics on elementary and secondary schools and degree-granting institutions. Included are projections of enrollment, graduates, teachers, and expenditures to the year 2018. This is the first edition of the "Projections of…

Low-cost solar array project and Proceedings of the 14th Project Integration Meeting

NASA Technical Reports Server (NTRS)

Mcdonald, R. R.

1980-01-01

Activities are reported on the following areas: project analysis and integration; technology development in silicon material, large area sheet silicon, and encapsulation; production process and equipment development; and engineering and operations, and the steps taken to integrate these efforts. Visual materials presented at the project Integration Meeting are included.

Translational proteomics in neurodegenerative diseases--16th HUPO BPP workshop September 5, 2011 Geneva, Switzerland.

PubMed

Gröttrup, Bernd; Böckmann, Miriam; Stephan, Christian; Marcus, Katrin; Grinberg, Lea T; Meyer, Helmut E; Park, Young Mok

2012-02-01

The HUPO Brain Proteome Project (HUPO BPP) held its 16th workshop in Geneva, Switzerland, on September 5, 2011 during the 10th HUPO World Congress. The focus was on launching the Human Brain Proteome Atlas as well as ideas, strategies and methodological aspects in clinical neuroproteomics. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Training Students in Community Health: A Novel Required Fourth-Year Clerkship at the University of Rochester

PubMed Central

McIntosh, Scott; Block, Robert C.; Kapsak, Gabrielle; Pearson, Thomas A.

2012-01-01

In 2004, community health became the 4th mission of the University of Rochester Medical Center, along with education, clinical care, and research. In that same year, a novel clerkship was added to the 4th-year curriculum that focuses on the “practice” of community health and preventive medicine. The goal is to offer intensive experiential training to develop skills in community health improvement by partnering with community agencies involved in health promotion and disease prevention. The learning objectives addressed include: community health assessment, risk behavior change, assurance of personal health services, advocacy and policy change, environmental interventions, community organization and partnership-building, and program evaluation. The clerkship involves 3 full days of didactic instruction, followed by 4 weeks of program development and implementation. Each student chooses a project that focuses on a specific target population, then designs it and incorporates public health knowledge, skills, and attitudes learned during the didactic component. Course directors then mentor students during project implementation. Students can begin “longitudinal” experiences in their first or second years to fold into the required clerkship. Innovations include a novel “Advocacy and Policy Change” module and a highly rated “Cultural Determinants of Health” lecture, and a resource-based course website. The clerkship was initially offered as an elective, and has since become a required course. In the clerkship to date, three hundred and forty students have launched hundreds of community-level interventions within various settings locally, nationally, and internationally. Evaluation efforts to date indicate the clerkship has been received favorably by both faculty and students. PMID:18367896

TH-EF-207A-05: Feasibility of Applying SMEIR Method On Small Animal 4D Cone Beam CT Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhong, Y; Zhang, Y; Shao, Y

Purpose: Small animal cone beam CT imaging has been widely used in preclinical research. Due to the higher respiratory rate and heat beats of small animals, motion blurring is inevitable and needs to be corrected in the reconstruction. Simultaneous motion estimation and image reconstruction (SMEIR) method, which uses projection images of all phases, proved to be effective in motion model estimation and able to reconstruct motion-compensated images. We demonstrate the application of SMEIR for small animal 4D cone beam CT imaging by computer simulations on a digital rat model. Methods: The small animal CBCT imaging system was simulated with themore » source-to-detector distance of 300 mm and the source-to-object distance of 200 mm. A sequence of rat phantom were generated with 0.4 mm{sup 3} voxel size. The respiratory cycle was taken as 1.0 second and the motions were simulated with a diaphragm motion of 2.4mm and an anterior-posterior expansion of 1.6 mm. The projection images were calculated using a ray-tracing method, and 4D-CBCT were reconstructed using SMEIR and FDK methods. The SMEIR method iterates over two alternating steps: 1) motion-compensated iterative image reconstruction by using projections from all respiration phases and 2) motion model estimation from projections directly through a 2D-3D deformable registration of the image obtained in the first step to projection images of other phases. Results: The images reconstructed using SMEIR method reproduced the features in the original phantom. Projections from the same phase were also reconstructed using FDK method. Compared with the FDK results, the images from SMEIR method substantially improve the image quality with minimum artifacts. Conclusion: We demonstrate that it is viable to apply SMEIR method to reconstruct small animal 4D-CBCT images.« less

Alpha-2A Adrenoceptor Agonist Guanfacine Restores Diuretic Efficiency in Experimental Cirrhotic Ascites: Comparison with Clonidine

PubMed Central

Sansoè, Giovanni; Aragno, Manuela; Mastrocola, Raffaella; Mengozzi, Giulio; Parola, Maurizio

2016-01-01

Background In human cirrhosis, adrenergic hyperfunction causes proximal tubular fluid retention and contributes to diuretic-resistant ascites, and clonidine, a sympatholytic drug, improves natriuresis in difficult-to-treat ascites. Aim To compare clonidine (aspecific α2-adrenoceptor agonist) to SSP-002021R (prodrug of guanfacine, specific α2A-receptor agonist), both associated with diuretics, in experimental cirrhotic ascites. Methods and Results Six groups of 12 rats were studied: controls (G1); controls receiving furosemide and potassium canrenoate (G2); rats with ascitic cirrhosis due to 14-week CCl4 treatment (G3); cirrhotic rats treated (over the 11th-14th CCl4 weeks) with furosemide and canrenoate (G4), furosemide, canrenoate and clonidine (G5), or diuretics and SSP002021R (G6). Three rats of each group had their hormonal status and renal function assessed at the end of 11th, 12th, 13th, and 14th weeks of respective treatments.Cirrhotic rats in G3 and G4 gained weight over the 12th-14th CCl4 weeks. In G4, brief increase in sodium excretion over the 11th-12th weeks preceded worsening of inulin clearance and natriuresis (diuretic resistance). In comparison with G4, the addition of clonidine (G5) or guanfacine (G6) to diuretics improved, respectively, sodium excretion over the 11th-12th CCl4 weeks, or GFR and electrolytes excretion over the 13th-14th CCl4 weeks. Natriuretic responses in G5 and G6 were accompanied by reduced catecholamine serum levels. Conclusions α2A-receptor agonists restore glomerular filtration rate and natriuresis, and delay diuretic-resistant ascites in experimental advanced cirrhosis. Clonidine ameliorates diuretic-dependent natriuresis just for a short time. PMID:27384184

Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia

PubMed Central

Saito, S; Sakai, M; Sasaki, Y; Tanebe, K; Tsuda, H; Michimata, T

1999-01-01

We calculated the percentage of Th1, Th2, Th0 cells and the Th1:Th2 cell ratio of peripheral blood from normal pregnant subjects and preeclampsia patients using flow cytometry which can analyse both the surface marker, CD4, and intracellular cytokines, interleukin (IL)-4 and interferon (IFN)-γ. In normal pregnancy, the percentage of Th1 cells was significantly lower in the third trimester, and the ratios of Th1:Th2 were significantly lower in the second and third trimester than in nonpregnant subjects. In contrast, the percentage of Th1 cells and the ratios of Th1:Th2 in preeclampsia were significantly higher than in normal third trimester pregnant subjects. The percentage of Th2 cells in preeclampsia was significantly lower than in third trimester of normal pregnancy. Additionally, peripheral blood mononuclear cells from these subjects and patients were cultured with phytohemagglutinin stimulation, and IL-4 and IFN-γ concentrations were determined in the supernatant by enzymed linked immunosorbent assays. The percentage of Th1 and Th2, and the ratios of Th1:Th2 were correlated with cytokine (IFN-γ and IL-4) secretion level. These results demonstrated that Th2 cells were predominant in the second and third trimesters of normal pregnancy, but Th1 cells predominated in preeclamptic patients. PMID:10469061

Acquisition Research: Creating Synergy for Informed Change. Proceedings of the Annual Acquisition Research Symposium (4th) Held in Monterey, California on 16-17 May 2007. Volume 2: Thursday Sessions

DTIC Science & Technology

2007-04-30

faculty research and student classroom instruction has been exceptional with many relevant and current instructional materials emerging from research...products, thus enhancing the student educational experience. Faculty are “refreshed” in defense-relevant subject matter, and students are better...DoD, industry and government leaders in acquisition, supervises student MBA projects and conducts guest lectures and seminars. Before serving at NPS

High-Energy Laser for Detection, Inspection, and Non-Destructive Testing

DTIC Science & Technology

2011-03-21

at the gra odes. The -2 at 0.1 Hz -cm-2, and mage thre n array of beam. Th burns on pled to a to measur laser is eq micron lev ent beam ( rget...project or resulting research?  Defense Threat Reduction Agency, “Compact Source of Laser -Driven Monoenergetic Gamma-Rays” --$2,982,685... LASER FOR DETECTION, INSPECTION, AND NON-DESTRUCTIVE TESTING 3) Grant/Contract Number: FA9550-07-1-0521 4) Reporting Period Start: 06/21/2007

Intelligence Fusion Paradigm: Understanding Complex Operational Environments Implementing the Institutional Analysis and Development Framework

DTIC Science & Technology

2012-12-14

NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Whitfield, Christy L., MAJOR, U.S. Army 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT...the level of details necessary to consumer’s needs. It must also contain accurate assessments 4 of all applicable material and apply to the end ...half of the 20th century , focused on cultural perspectives as a pivotal concern regarding economic, political, and military powers and its global

The Cuban Missile Crisis: Considering Its Place in Cold War History. Teacher's Resource Book [and Student Text]. Public Policy Debate in the Classroom. Choices for the 21st Century Education Project. 4th Edition.

ERIC Educational Resources Information Center

Soukup, Nancy, Ed.

Like no other region on the globe, the Caribbean Basin has served as a testing ground for U.S. foreign policy. Of all the countries in the region, Cuba has been the scene of many of the United States' most riveting foreign policy dramas. The teacher resource book and student text probe the complex, often troubled, relationship between the United…

Defense Small Business Innovation Research Program (SBIR). Volume 1. Army Projects, Abstracts of Phase 1 Awards from FY 1989 SBIR Solicitation

DTIC Science & Technology

1990-04-01

CONTRACT NUMBER: WILLIAM R BELCHER TITLE: SORBENTS FOR DECONTAMINATION OF CHEMICAL WARFARE AGENTS TOIC# 2 OFFICE: CRDEC IDENT#: 33401 SMALL BUSINESS...INDUSTRIES PO BOX 4338 - 4 LEONARD ST METUCHEN, NJ 08340 CONTRACT NUMBER: DR ASIT ROY TITLE: NOVEL ACTIVE SORBENTS FOR DECONTAMINATION OF CHEMICAL WARFARE AGE...DEFERRED TO PHASE II. BELTRAN INC 1133 E 35TH ST BROOKLYN, NY 11210 CONTRACT NUMBER: DR CONSTANCE SIMO TITLE: CONTROLLED CHEMICAL MODIFICATION OF

Advanced Technology for Aero Gas Turbine Components: Conference Proceedings Held at the Propulsion and Energetics Panel (69th) Symposium in Paris (France) on 4-8 May 1987

DTIC Science & Technology

1987-09-01

v PROPULSION AND ENERGETICS PANEL Chairman: Dr W.L.Macmillan Depuity Chairman: Ing. Principal de l’Armement P.Ramene Project Manager DRET EHF...initiative in historical perspective, describe the HPTET technical/ management approach, discuss some of the Dromising candidate technologies and present...the combustion process must be carefully managed to eliminate fuel-rich areas which could produce visible smoke in the engine exhaust. The combustor

Cultural Resources Survey, Harry S. Truman Dam and Reservoir Project, Missouri. Volume 4. The Archeological Survey

DTIC Science & Technology

1983-02-01

by block numb»r> Th« ten volumes report Che results of a cultural resources survey in the Harry S. Truman Dam and Reservoir Proiect, Henry, Benton...It has been emphasized throughout this report that a research oriented approach has been taken to the arche- ological survey of the Harry S...assess the reliability of the survey. This chapter has therefore had two purposes: (1) to report the findings of the archeological survey of the Harry

Research on Coastal Marine Systems. Review and Recommendations for Unesco Programme 1987-1989. Unesco Technical Papers in Marine Science No. 52. Report of the Meeting of the Unesco/SCOR/IABO Consultative Panel on Coastal Systems (4th, Dakar, Senegal, December 15-17, 1986).

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France). Div. of Marine Sciences.

This report contains a detailed analysis, both retrospective and prospective, of the Unesco Major Interregional Coastal Marine (COMAR) Project. The report cites achievements during the period 1985-1986 and reviews plans for the various COMAR components for the triennium 1987-1989. Activities under review include: (1) co-operation with ICSU and its…

A Bibliography of Selected Publications: Project Air Force, 5th Edition

DTIC Science & Technology

1989-05-01

Dyna - R-3028-AF. A Dynamic Retention Model for Air Force Officers: METRIC’s DL and and Pipeilne Variability. M. J. Carrillo. Theory and Estimates. G...Theorem and Dyna - and Support. METRIC’s Demand and Pipeline Variability. R-3255-AF. Aircraft Airframe Cost Estimating Relationships: N-2283/1-AF...U). 1970-1985. N-2409-AF. Tanker Splitting Across the SlOP Bomber Force R-3389-AF. Dyna -METRIC Version 4: Modeling Worldwide (U). Logistics Support of

Effect of ginseng polysaccharides and dendritic cells on the balance of Th1/Th2 T helper cells in patients with non-small cell lung cancer.

PubMed

Ma, Junjie; Liu, Huiping; Wang, Xiaolong

2014-12-01

To investigate the effect of thorascopic administration.of ginseng polysaccharides (GPS) plus dendritic cells (DC) on T helper cell type 1/T helper cell type 2 (Th1/Th2) balance in patients with non-small cell lung cancer (NSCLC). A total of 96 NSCLC patients were divided evenly into two groups. The control group was treated with DCs alone and the treatment group was treated with DCs plus GPS. After DCs and GPS were administered thoracoscopically, once a week, 4 times for 30 days, the patients' quality of life was measured with the Functional Assessment of Cancer Treatment-Lung (FACT-L) questionnaire before and after treatment. Serum interferon-γ (INF-γ), interleukin-4 (IL-4), IL-2 and IL-5 were examined before and after treatments. The level of Th1 cytokines (INF-γ, IL-2) and the ratio of Th1/Th2 cytokines (INF-γ/IL-4, IL-2/ IL-5) increased in both treatment groups, while Th2 cytokines (IL-4, IL-5) and FACT-L scores decreased (P < 0.01). Furthermore, after treatment Th1 cytokines (INF-γ, IL-2) and the ratio of Th1/Th2 cytokines (INF-γ/IL-4, IL-2/IL-5) were higher in the DCs + GPS group than in the control group (P < 0.05). Conversely, FACT-L scores and Th2 cytokines (IL-4, IL-5) were higher in the control group than in the DCs + GPS group (P < 0.05). The treatment regime of DCs plus GPS had a greater effect on NSCLC patients' immune function as compared with DCs alone. This was evident by increased expression of Th1 cytokines (INF-γ, IL-2) and the ratio of Th1/Th2 (INF-γ/IL-4, IL-2/IL-5), as well as by decreased FACT-L scores and the expression of Th2 cytokines (IL-4, IL-5).

Assessment of Elementary School Students’ Sun Protection Behaviors

PubMed Central

Hunter, Seft; Wells, Kristen J.; Jacobsen, Paul B.; Lee, Ji-Hyun; Boulware, David; Love-Jackson, Kymia; Abdulla, Rania; Roetzheim, Richard G.

2013-01-01

Introduction Emerging studies suggest that excessive sun exposure in childhood contributes to the development of skin cancer later in life. Children rarely wear a wide-brimmed hat when outside although these hats offer the best protection to the areas on the face where children are most likely to be sunburned. The current study explores 4th grade student assessment of their sun protection behaviors outside at school and at times other than when they are at school. Method This study utilized baseline data collected in the Fall of 2006 for the Sun Protection for Florida’s Children (SPF) project. In brief, the SPF project is a group randomized trial to test the effectiveness of a school based intervention promoting sun protection in general, and hat use in particular. The project targets all 4th grade students in Hillsborough County Schools, FL. The data reported in this study were collected at baseline before any intervention activities was initiated. Approximately 2,086 4th grade students completed self-report surveys evaluating sun protection behaviors. Trained research assistants carried out 99 direct observations of physical education classes over a five week period during Fall 2006 in Tampa, Florida. Results In general, the self-reported use of various methods of sun protection was low. Approximately one third of students reported that they wore sunscreen (32.8%) or sunglasses (32.3%) before leaving home for school. Only a small percentage of students wore long sleeves (15.0%) or a hat with a brim (16.4%) before leaving for school. In addition, few students wore a hat with a wide brim when outside but not at school (16.4%). Students spent an average of 59.1 minutes per week outdoors while attending school and 35.5 minutes during peak sun exposure. In general, female students and Hispanic, African American, and students of other racial and ethnic groups were more likely to practice sun protection behaviors at school than white or male students. Students who attended schools with a mandatory uniform policy were less likely to wear hats with brims. Discussion A single sunburn heightens a child’s risk of developing skin cancer later on in life. Sun exposure at school poses a significant risk to student health and more needs to be done to promote the use of a wide-brimmed hat and limiting student sun exposure. A wide brimmed hat shows the most promise in helping students to protect the face at neck areas where sunburns are most likely to develop. More needs to be done to promote hat use and limiting sun exposure while children are at school. PMID:19686304

Rapid stimulation of sodium intake combining aldosterone into the 4th ventricle and the blockade of the lateral parabrachial nucleus.

PubMed

Gasparini, S; Melo, M R; Leite, G F; Nascimento, P A; Andrade-Franzé, G M F; Menani, J V; Colombari, E

2017-03-27

Chronic infusion of aldosterone into the 4th ventricle (4th V) induces robust daily sodium intake, whereas acute injection of aldosterone into the 4th V produces no sodium intake. The inhibitory mechanism of the lateral parabrachial nucleus (LPBN) restrains sodium intake induced by different natriorexigenic stimuli and might affect the acute response to aldosterone into the 4th V. In the present study, 1.8% NaCl and water intake was tested in rats treated with acute injections of aldosterone into the 4th V combined with the blockade of the inhibitory mechanisms with injections of moxonidine (α 2 adrenergic/imidazoline agonist) or methysergide (a serotonergic antagonist) into the LPBN. Male Holtzman rats with stainless steel cannulas implanted in the 4th V and bilaterally in the LPBN were used. Aldosterone (250 or 500ng) into the 4th V combined with vehicle into the LPBN induced no 1.8% NaClintake compared to control (1.5±1.1 and 1.1±0.4, respectively, vs. vehicle into 4th V: 1.0±0.5ml/2h). However, aldosterone (250 or 500ng) into the 4th V combined with moxonidine (0.5nmol) into the LPBN induced strong ingestion of 1.8% NaCl (12.7±4.6 and 17.6±3.7ml/2h, respectively). Aldosterone (250ng) into the 4th V combined with methysergide (4μg) into the LPBN also induced 1.8% NaCl intake (17.6±5.4ml/2h). These data suggest that the inhibitory mechanisms of the LPBN counteract the facilitation of sodium intake produced by aldosterone injected into the 4th, restraining sodium intake in this condition. Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

A Continuous Quality Improvement Project to Implement Infant-Driven Feeding as a Standard of Practice in the Newborn/Infant Intensive Care Unit.

PubMed

Chrupcala, Kimberly A; Edwards, Taryn M; Spatz, Diane L

2015-01-01

To increase the number of neonates who were fed according to cues prior to discharge and potentially decrease length of stay. Continuous quality improvement. Eighty-five bed level IV neonatal intensive care unit. Surgical and nonsurgical neonates of all gestational ages. Neonates younger than 32 weeks gestation, who required intubation, continuous positive airway pressure (CPAP), high flow nasal cannula (HFNC), or did not have suck or gag reflexes were excluded as potential candidates for infant-driven feeding. The project was conducted over a 13-month period using the following methods: (a) baseline data collection, (b) designation of Infant Driven Feeding (IDF) Champions, (c) creation of a multidisciplinary team, (d) creation of electronic health record documentation, (e) initial staff education, (f) monthly team meetings, (g) reeducation throughout the duration of the project, and (h) patient-family education. Baseline data were collected on 20 neonates with a mean gestational age of 36 0/7(th) weeks and a mean total length of stay (LOS) of 43 days. Postimplementation data were collected on 150 neonates with a mean gestational age of 36 1/7(th) weeks and a mean total LOS of 36.4 days. A potential decrease in the mean total LOS of stay by 6.63 days was achieved during this continuous quality improvement (CQI) project. Neonates who are fed according to cues can become successful oral feeders and can be safely discharged home regardless of gestational age or diagnosis. © 2015 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses.

High performance multichannel photonic biochip sensors for future point of care diagnostics: an overview on two EU-sponsored projects

NASA Astrophysics Data System (ADS)

Giannone, Domenico; Kazmierczak, Andrzej; Dortu, Fabian; Vivien, Laurent; Sohlström, Hans

2010-04-01

We present here research work on two optical biosensors which have been developed within two separate European projects (6th and 7th EU Framework Programmes). The biosensors are based on the idea of a disposable biochip, integrating photonics and microfluidics, optically interrogated by a multichannel interrogation platform. The objective is to develop versatile tools, suitable for performing screening tests at Point of Care or for example, at schools or in the field. The two projects explore different options in terms of optical design and different materials. While SABIO used Si3N4/SiO2 ring resonators structures, P3SENS aims at the use of photonic crystal devices based on polymers, potentially a much more economical option. We discuss both approaches to show how they enable high sensitivity and multiple channel detection. The medium term objective is to develop a new detection system that has low cost and is portable but at the same time offering high sensitivity, selectivity and multiparametric detection from a sample containing various components (e.g. blood, serum, saliva, etc.). Most biological sensing devices already present on the market suffer from limitations in multichannel operation capability (either the detection of multiple analytes indicating a given pathology or the simultaneous detection of multiple pathologies). In other words, the number of different analytes that can be detected on a single chip is very limited. This limitation is a main issue addressed by the two projects. The excessive cost per test of conventional bio sensing devices is a second issue that is addressed.

Development of an Enzyme-Linked Immunosorbent Assay Using a Recombinant LigA Fragment Comprising Repeat Domains 4 to 7.5 as an Antigen for Diagnosis of Equine Leptospirosis

PubMed Central

Yan, Weiwei; Saleem, Muhammad Hassan; McDonough, Patrick; McDonough, Sean P.; Divers, Thomas J.

2013-01-01

Leptospira immunoglobulin (Ig)-like (Lig) proteins are a novel family of surface-associated proteins in which the N-terminal 630 amino acids are conserved. In this study, we truncated the LigA conserved region into 7 fragments comprising the 1st to 3rd (LigACon1-3), 4th to 7.5th (LigACon4-7.5), 4th (LigACon4), 4.5th to 5.5th (LigACon4.5–5.5), 5.5th to 6.5th (LigACon5.5–6.5), 4th to 5th (LigACon4-5), and 6th to 7.5th (LigACon6-7.5) repeat domains. All 7 recombinant Lig proteins were screened using a slot-shaped dot blot assay for the diagnosis of equine leptospirosis. Our results showed that LigACon4-7.5 is the best candidate diagnostic antigen in a slot-shaped dot blot assay. LigACon4-7.5 was further evaluated as an indirect enzyme-linked immunosorbent assay (ELISA) antigen for the detection of Leptospira antibodies in equine sera. This assay was evaluated with equine sera (n = 60) that were microscopic agglutination test (MAT) negative and sera (n = 220) that were MAT positive to the 5 serovars that most commonly cause equine leptospirosis. The indirect ELISA results showed that at a single serum dilution of 1:250, the sensitivity and specificity of ELISA were 80.0% and 87.2%, respectively, compared to those of MAT. In conclusion, an indirect ELISA was developed utilizing a recombinant LigA fragment comprising the 4th to 7.5th repeat domain (LigACon4-7.5) as a diagnostic antigen for equine leptospirosis. This ELISA was found to be sensitive and specific, and it yielded results that concurred with those of the standard MAT. PMID:23720368

Childhood Obesity Research Demonstration project: Cross-site evaluation method

USDA-ARS?s Scientific Manuscript database

The Childhood Obesity Research Demonstration (CORD) project links public health and primary care interventions in three projects described in detail in accompanying articles in this issue of Childhood Obesity. This article describes a comprehensive evaluation plan to determine the extent to which th...

Transducer Workshop (15th), Held in Cocoa Beach, Florida on June 20-22, 1989

DTIC Science & Technology

1989-06-01

PROjECT TASK WORK UNITELEMENT NO NO NO ACCESS;ON NO 11 TITLE (Include Security Classification) FIFTEENTH TRANSDUCER WORKSHOP (UNCLASSIFIED) 12 ...8217 -17 - N~G m1 N𔃾 C𔃾L Nr - -4 -4 m in aO aO as I ’ (,40 m’ I𔃺 m C c l0 a (n I O1 E4 -1.- C’l- 1~ 4 ~ - 4 (𔃾 -4 N -4 N-- (4 0. 0011 4 I 0 U u $4C 4) 4...senso’ ! C n I c T . v p Thrill s Fro, mu, b e i ’rv e~ in te f i ld1 us i nr : er ;’nFiree’ I t h andI he In o e’ v pe ra t ed’ PT RON I? T - L i r

17th Chromosome-Centric Human Proteome Project Symposium in Tehran.

PubMed

Meyfour, Anna; Pahlavan, Sara; Sobhanian, Hamid; Salekdeh, Ghasem Hosseini

2018-04-01

This report describes the 17th Chromosome-Centric Human Proteome Project which was held in Tehran, Iran, April 27 and 28, 2017. A brief summary of the symposium's talks including new technical and computational approaches for the identification of novel proteins from non-coding genomic regions, physicochemical and biological causes of missing proteins, and the close interactions between Chromosome- and Biology/Disease-driven Human Proteome Project are presented. A synopsis of decisions made on the prospective programs to maintain collaborative works, share resources and information, and establishment of a newly organized working group, the task force for missing protein analysis are discussed. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Eratosthenes Made Easy

NASA Astrophysics Data System (ADS)

Romani, P.; Hackett, K.; Kaplan, T.

1996-09-01

In May of this year 5th grade students at Glenarden Woods Elementary School in Glenarden, Maryland and 4th grade students at Wildwood Elementary School in Amherst, Massachusetts worked together to duplicate Eratosthenes's measurement of the circumference of the Earth. Eratosthenes was a Greek who lived and experimented in Egypt in the Ptolemaic era. His determination of the Earth's circumference was within 15% of the modern day value. The original purpose for the project was to add math and science into a thematic study of ancient Egypt that already involved language arts, social studies, and art. The experiment can also be used for discussions about what information was available to early explorers, e. g. Columbus's reasoning that it was feasible to sail from Europe to Japan was based upon a value of the Earth's circumference much smaller than what Eratosthenes had calculated. Besides these connections it was a great activity by itself for the students to learn and apply science process skills. The final error in the students' determination of the circumference of the Earth was on the order of Eratosthenes's error. We will present how we did the project, the worksheets the students used, and lessons learned.

The Pace of Perceivable Extreme Climate Change

NASA Astrophysics Data System (ADS)

Tan, X.; Gan, T. Y.

2015-12-01

When will the signal of obvious changes in extreme climate emerge over climate variability (Time of Emergence, ToE) is a key question for planning and implementing measures to mitigate the potential impact of climate change to natural and human systems that are generally adapted to potential changes from current variability. We estimated ToEs for the magnitude, duration and frequency of global extreme climate represented by 24 extreme climate indices (16 for temperature and 8 for precipitation) with different thresholds of the signal-to-noise (S/N) ratio based on projections of CMIP5 global climate models under RCP8.5 and RCP4.5 for the 21st century. The uncertainty of ToE is assessed by using 3 different methods to calculate S/N for each extreme index. Results show that ToEs of the projected extreme climate indices based on the RCP4.5 climate scenarios are generally projected to happen about 20 years later than that for the RCP8.5 climate scenarios. Under RCP8.5, the projected magnitude, duration and frequency of extreme temperature on Earth will all exceed 2 standard deviations by 2100, and the empirical 50th percentile of the global ToE for the frequency and magnitude of hot (cold) extreme are about 2040 and 2054 (2064 and 2054) for S/N > 2, respectively. The 50th percentile of global ToE for the intensity of extreme precipitation is about 2030 and 2058 for S/N >0.5 and S/N >1, respectively. We further evaluated the exposure of ecosystems and human societies to the pace of extreme climate change by determining the year of ToE for various extreme climate indices projected to occur over terrestrial biomes, marine realms and major urban areas with large populations. This was done by overlaying terrestrial, ecoregions and population maps with maps of ToE derived, to extract ToEs for these regions. Possible relationships between GDP per person and ToE are also investigated by relating the mean ToE for each country and its average value of GDP per person.

Influence of Prior Knowledge and Interest on Fourth- and Fifth-Grade Passage Comprehension on the Qualitative Reading Inventory-4

ERIC Educational Resources Information Center

Clark, Mary Kristen; Kamhi, Alan G.

2014-01-01

Purpose: In 2 experiments, we examined the influence of prior knowledge and interest on 4th- and 5th-grade students' passage comprehension scores on the Qualitative Reading Inventory-4 (QRI-4) and 2 experimenter constructed passages. Method: In Experiment 1, 4th- and 5th-grade students were administered 4 Level 4 passages or 4 Level 5…

Multiple-Purpose Project, Kansas River Basin, Republican River, Kansas, Milford Lake Operation and Maintenance Manual. Appendix IV. Construction Foundation Report. Revision.

DTIC Science & Technology

1983-10-01

NUMBERS oundaton and Materia s Branch (MKED-F) PB-2b and Konsas Rity Dlstrict Corps Q neers ER 1110-1-1801, Change 2, 601 E. 12th Street, kansa City...34 ,A M’LFORD DA BLASTING RECORD TABLE 2 I3ALA’N CRLS DELA PRIMA ONV 04W b 0 r C L,- A NIA A . A A A . 4 AACOR-.ESULT NETTOORERAA.uALL2AAO4 48...,,e...4 to 6 X to I-os 55 0 2 SIX) MILFORD AM BLASTING RECORD - TABLE 4 LOADING CAPS DELAYS PRIMA BPYC u OS U .Oo 0 0 2 A N 1R.0.p’ot LIR tO I I 2 3 4 S

[Post-marketing re-evaluation of Kudiezi injection study on early treatment in patients with ischemic stroke].

PubMed

Ye, Xiaoqin; Wei, Xu; Xie, Yanming; Zou, Yihuai; Zhao, Xingquan; Han, Jianhua; Wang, Xinzhi; Ma, Yunzhi; Bi, Qi; Xie, Qingfan; Zhao, Jianjun; Cao, Xiaolan; Chen, Hongxia; Wang, Shizhong; Yan, Rongmei; Han, Zucheng; Yi, Danhui; Wang, Yongyan

2011-10-01

To study the effect and safety of Kudiezi injection on patients with acute ischemic stroke. Seven hundreds patients were divided into two groups by central randomization system. The study group, 346 cases, was treated with kudiezi injection plus traditional Chinese medicine (TCM) synthesis rehabilitation project, and the control group, 354 cases, was treated with synthetic rehabilitation project. The patients were treated for 10 to 21 days. Before treatment and at the 7th, 14th and 21th day of treatment, the indexes include NIHSS used for evaluating the neurological deficit degree and the motor function score (Fugl-Meyer) for evaluating motor function were observed. The safety index is defined by adverse observation event and laboratory test. The incidence of adverse events and laboratory tests results were observed before and after treatment at the same time. Application of generalized estimating equation model, we found that as the treatment time, NIHSS score and FMI score of the two groups showed a trend of improvement. And at the 14th days and 21th days of treatment, compared to the control group the treatment group showed significant statistical difference on the impact of NIHSS and FMI (P<0.05). No serious adverse events were observed. Kudiezi injection plus TCM rehabilitation project of ischemic stroke showed some superiority to western medicine rehabilitation program on improving the neurological deficit and motor function. Kudiezi injection is safe and effective in the treatment of acute ischemic stroke.

Uranium from German Nuclear Power Projects of the 1940s— A Nuclear Forensic Investigation

PubMed Central

Mayer, Klaus; Wallenius, Maria; Lützenkirchen, Klaus; Horta, Joan; Nicholl, Adrian; Rasmussen, Gert; van Belle, Pieter; Varga, Zsolt; Buda, Razvan; Erdmann, Nicole; Kratz, Jens-Volker; Trautmann, Norbert; Fifield, L Keith; Tims, Stephen G; Fröhlich, Michaela B; Steier, Peter

2015-01-01

Here we present a nuclear forensic study of uranium from German nuclear projects which used different geometries of metallic uranium fuel.3b,d, 4 Through measurement of the 230Th/234U ratio, we could determine that the material had been produced in the period from 1940 to 1943. To determine the geographical origin of the uranium, the rare-earth-element content and the 87Sr/86Sr ratio were measured. The results provide evidence that the uranium was mined in the Czech Republic. Trace amounts of 236U and 239Pu were detected at the level of their natural abundance, which indicates that the uranium fuel was not exposed to any major neutron fluence. PMID:26501922

Subjective depth of field in presence of 4th-order and 6th-order Zernike spherical aberration using adaptive optics technology.

PubMed

Benard, Yohann; Lopez-Gil, Norberto; Legras, Richard

2010-12-01

To study the impact on the subjective depth of field of 4th-order spherical aberration and its combination with 6th-order spherical aberration and analyze the accuracy of image-quality metrics in predicting the impact. Laboratoire Aimé Cotton, Centre National de la Recherche Scientifique, Université Paris-Sud, Orsay, France. Case series. Subjective depth of field was defined as the range of defocus at which the target (3 high-contrast letters at 20/50) was perceived acceptable. Depth of field was measured using 0.18 diopter (D) steps in young subjects with the addition of the following spherical aberration values: ±0.3 μm and ±0.6 μm 4th-order spherical aberration with 3.0 mm and 6.0 mm pupils and ±0.3 μm 4th-order spherical aberration with ±0.1 μm 6th-order spherical aberration for 6.0 mm pupils. The addition of ±0.3 and ±0.6 μm 4th-order spherical aberration increased depth of field by 30% and 45%, respectively. The combination of 4th-order spherical aberration and 6th-order spherical aberration of opposite signs increased depth of field more than 4th-order spherical aberration alone (ie, 63%), while the combination of 4th-order spherical aberration and 6th-order spherical aberration of the same signs did not (ie, 24%). Whereas the midpoint of the depth of field could be predicted by image-quality metrics, none was found a good predictor of objectionable depth of field. Subjective depth of field increased when 4th-order spherical aberration and 6th-order spherical aberration of opposite signs were added but could not be predicted with image-quality metrics. Copyright © 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

Evaluation of utility relocation costs and best management practices : final report : SCDOT research project 684.

DOT National Transportation Integrated Search

2014-05-21

In recent years, the SCDOT has experienced a significant variation in estimated costs for the relocation of : utilities on many projects. This has led to cost overruns and caused headaches for the district engineers : responsible for the projects. Th...

8. Center bay of the east elevation (Note project supervisor ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Center bay of the east elevation (Note project supervisor Mary Ellen Strain and project historian James Jacobs discussing the extant house in reference to a 1758 drawing of the structure). - John Bartram House & Garden, House, 54th Street & Lindbergh Boulevard, Philadelphia, Philadelphia County, PA

Phase I clinical trial of costimulated, IL-4 polarized donor CD4+ T cells as augmentation of allogeneic hematopoietic cell transplantation.

PubMed

Fowler, Daniel H; Odom, Jeanne; Steinberg, Seth M; Chow, Catherine K; Foley, Jason; Kogan, Yelena; Hou, Jeannie; Gea-Banacloche, Juan; Sportes, Claude; Pavletic, Steven; Leitman, Susan; Read, Elizabeth J; Carter, Charles; Kolstad, Arne; Fox, Rebecca; Beatty, Gregory L; Vonderheide, Robert H; Levine, Bruce L; June, Carl H; Gress, Ronald E; Bishop, Michael R

2006-11-01

The primary objective of this clinical trial was to evaluate the safety, feasibility, and biologic effects of administering costimulated, interleukin (IL)-4 polarized donor CD4(+) T cells in the setting of HLA-matched sibling, T cell-replete allogeneic hematopoietic cell transplantation (HCT). Forty-seven subjects with hematologic malignancy received granulocyte colony-stimulating factor-mobilized allogeneic hematopoietic cell transplants and cyclosporine graft-versus-host disease (GVHD) prophylaxis after reduced intensity conditioning. Initial subjects received no additional cells (n = 19); subsequent subjects received additional donor CD4(+) T cells generated ex vivo by CD3/CD28 costimulation in medium containing IL-4 and IL-2 (administered day 1 after HCT at 5, 25, or 125 x 10(6) cells/kg). Studies after HCT included measurement of monocyte IL-1alpha and tumor necrosis factor alpha, detection of T cells with antitumor specificity, and characterization of T cell cytokine phenotype. The culture method generated donor CD4(+) T cells that secreted increased T helper 2 (Th2) cytokines and decreased T helper 1 (Th1) cytokines. Such Th2-like cells were administered without infusional or dose-limiting toxicity. The Th2 cohort had accelerated lymphocyte reconstitution; both cohorts had rapid hematopoietic recovery and alloengraftment. Acute GVHD and overall survival were similar in the Th2 and non-Th2 cohorts. Th2 cell recipients tended to have increased monocyte IL-1alpha and had increased tumor necrosis factor alpha secretion. CD8(+) T cells with antitumor specificity were observed in Th2 and non-Th2 cohorts. Post-transplantation T cells from Th2 cell recipients secreted IL-4 and IL-10 (Th2 cytokines) and IL-2 and interferon gamma (Th1 cytokines). Allograft augmentation with costimulated, IL-4-polarized donor CD4(+) T cells resulted in activated Th1, Th2, and inflammatory cytokine pathways without an apparent increase in GVHD.

Kindergarten through 12th Grade Project in Career Development and Bridging the Gap Between School and Work: Final Report.

ERIC Educational Resources Information Center

Watertown Independent School District 1, SD.

Divided into four phases, this project in career education includes the following aspects: planning of project policies and activities and securing resource materials; orientation of the school district staff to the project; integration of occupational information, exploration, and career education concepts into the curriculum, identification of…

Evolution: A Programmed Text [And] Pronunciation Guide for Evolution. Publications No. 71-8 and 71-1.

ERIC Educational Resources Information Center

Thomas, Georgelle; Fishburne, Robert P.

Part of the Anthropology Curriculum Project, the document contains a programmed text on evolution and a vocabulary pronunciation guide. The unit is intended for use by students in social studies and science courses in the 5th, 6th, and 7th grades. The bulk of the document, the programmed text, is organized in a question answer format. Students are…

26 CFR 1.6073-4 - Extension of time for filing declarations by individuals.

Code of Federal Regulations, 2010 CFR

2010-04-01

... of the 4th month of his taxable year, an extension of time for filing his declaration of estimated tax otherwise due on or before the 15th day of the 4th month of the taxable year is granted to and... States and Puerto Rico on the 15th day of the 4th month of a taxable year beginning after December 31...

[Assessing the trend in the aging of the nursing staff at two hospitals of the Friuli Venezia Giulia region: application of a deterministic mathematical model].

PubMed

Guardini, Ilario; Deroma, Laura; Salmaso, Daniele; Palese, Alvisa

2011-01-01

The aging of the nursing workforce is a phenomenon that several industrialized countries has been facing for at least a decade. In Italy, for the period between 2011 and 2021, the issue associated with the nursing workforce will not be one of shortage but rather one of aging. The main objective of this study was to estimate the employed nurse population aging trends for the period 2009-2035 in two Teaching Hospitals (TH1 and TH2) located in the North of Italy. A deterministic mathematical model has been developed in order to obtain aging projections for the nursing workforce from 2009 until 2035. Within the next six years, the aging trend of nurse populations, with respect to 2008, at the TH 1 and 2 will show a steady increase of nurses aged over 45; specifically, a 29.4% vs. 34.1% increase and a 21.6% vs. 41.4% respectively. It is hypothesized that the TH 1 will have the highest proportion of nurses aged over 45 in 2014, whereas it is estimated that for the TH 2 this trend will continue until 2021 when the proportion of nurses aged over 45 will make up 48.8% out of the nurse population. The trend may lead to an increase in the number of experienced nurses; however, such a trend should be looked at with concern, with respect to the physical unsuitability. Nurses aged over 45 represent 20% of the workforce at both TH. Conclusions/implications for management and research. If the trend predicted by the model were to occur in the coming years, the problem of nursing workforce ageing will have to be addressed because it involves different expectations but also the perception of different work skills. The nursing direction is called to test new strategies for managing the staff and the career of nurses will also need to be redesigned, because contract law looks primarily at the initial stage of working life (specializations, university education, career opportunities) neglecting the final one (from the 50th year of age to retirement).

The Village Green Project: Lesson Plans for K-8 Educators

EPA Science Inventory

This document contains lesson plans spanning kindergarten through 8th grade, that are written to connect next-generation science standards (USA) to the Village Green Project and related air quality topics.

A 50-year precipitation analysis over Europe at 5.5km within the UERRA project

NASA Astrophysics Data System (ADS)

Bazile, Eric; Abida, Rachid; Soci, Cornel; Verrelle, Antoine; Szczypta, Camille; Le Moigne, Patrick

2017-04-01

The UERRA project is a 4-year project (2014-2017) financed by the European Union under its 7th Framework Programme SPACE. One of its main objectives is to provide a 50-year reanalysis dataset of surface essential climate variables (ECV) at 5.5km grid at European scale, together with, as much as possible, uncertainty estimates. One of the ECV is the precipitation and this variable is of essential interest in weather forecasting, climate study and to "drive" hydrological model for water management, or agrometeorology. After a brief description of the method used for the precipitation analysis (Soci et al. 2016)during this project, the preliminary results will be presented. The estimation of uncertainties will be also discussed associated with the problem of the evolution of the observation density network and its impact on the long term series. Additional information about the UERRA project can be found at http://www.uerra.eu The research leading to these results has received funding from the European Union, Seventh Framework Programme (FP7-SPACE-2013-1) under grant agreement no 607193.

Meteor Beliefs Project: some meteoric imagery in the works of William Shakespeare

NASA Astrophysics Data System (ADS)

McBeath, A.; Gheorghe, A. D.

2003-08-01

Passages from three of William Shakespeare's plays are presented, illustrating some of the beliefs in meteors in 16th-17th century England. They also reflect earlier beliefs and information which it is known Shakespeare drew on in constructing his works.

Spatial and Temporal Distribution of Initial 230TH/232TH in Sumatran Corals and its Influence on the Accurate Dating of Young Corals

NASA Astrophysics Data System (ADS)

Chiang, H.; Shen, C.; Meltzner, A. J.; Philibosian, B.; WU, C.; Sieh, K. E.; Wang, X.

2012-12-01

Accurate and precise determination of initial 230Th/232Th (230Th/232Th0) is important in dating young fossil corals, and it can significantly influence our understanding of paleoclimate, paleoceanographic and paleoseismic histories. A total of 47 unpublished and published isochrons (Shen et al., 2008; Meltzner et al., 2010, 2012; Philibosian et al., 2012), covering most of the Sumatran outer-arc islands, provide a more robust estimate of the 230Th/232Th0 variability in the region. The weighted average of 230Th/232Th0 atomic values is 4.7 (+5.5/-4.7) × 10-6 (2σ), consistent with the previously reported value of 6.5 ± 6.5 × 10-6 obtained from a handful of samples from the southern part of Sumatran outer-arc. Specifically, the calculated 230Th/232Th0 in the north and south are identical. The weighted mean of 3.5 (+7.0/-3.5) × 10-6 for fossil corals of 300-2000-yr old is slightly lower than the value of 5.4 ± 4.5 × 10-6 obtained from corals younger than 300 yrs B.P.. For corals containing less than 2 ppb of thorium, however, the age offset will be less than 10 yr by using different 230Th/232Th0, which is acceptable for most studies. We hereby recommend an updated 230Th/232Th0 value of 4.7 (+5.5/-4.7) × 10-6 for corals throughout the Sumatran outer-arc islands. For very high-precision age determination (<10 yr), coral samples with low Th concentration (< 2 ppb) are preferred.; ;

The first US Naval Observatory CCD Astrograph Catalog

NASA Astrophysics Data System (ADS)

Germain, M. E.; Zacharias, N.; Urban, S. E.; Rafferty, T. J.; Holdenried, E. R.; Zacharias, M. I.; Hall, D. M.; Wycoff, G. L.; Monet, D. G.

2000-05-01

The USNO CCD Astrograph Catalog (UCAC) project is a high precision, astrometric survey of stars having R magnitudes between 7th and 16th. The positional accuracy is 20 mas for stars between 9th and 14th, and 70 mas for fainter stars. This gives a density (stars per square degree) higher than that of the Guide Star Catalog (GSC), with an improvement in positional accuracy of about a factor of ten. Observations began in January 1998 at Cerro Tololo Inter--American Observatory (CTIO) using a five-element 0.2 meter astrograph equipped with a 4k by 4k CCD. The instrument will be moved north in early 2001, and full sky coverage is expected by early 2003. A preliminary catalog (UCAC1) of positions and proper motions of 27 million stars has been constructed which is available on CD-ROM from USNO. Observations between 13 Feb 1998 and 07 Nov 1999 are included with a total of over 79,000 CCD frames covering 80% of the Southern Hemisphere. The catalog is on the International Celestial Reference System (ICRS), which is consistent with J2000. Proper motions of bright stars (V <= 12.5) were derived using a combination of ground-based astrometric catalogs, Hipparcos, and Tycho-2 positions, giving a typical error of 3 mas/yr. For the fainter stars the USNO A2.0 (Monet, 1998) was used as first epoch, with typical proper motion errors of 10 to 15 mas/yr. External comparisons with Tycho-2 and the Yale Southern Proper Motion (SPM) 2.0 data reveal systematic errors to be only on the 10 mas level.

Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo.

PubMed

Wu, Lin; Pan, Lifeng; Wei, Zhiyi; Zhang, Mingjie

2011-02-11

The unconventional myosin VIIa (MYO7A) is one of the five proteins that form a network of complexes involved in formation of stereocilia. Defects in these proteins cause syndromic deaf-blindness in humans [Usher syndrome I (USH1)]. Many disease-causing mutations occur in myosin tail homology 4-protein 4.1, ezrin, radixin, moesin (MyTH4-FERM) domains in the myosin tail that binds to another USH1 protein, Sans. We report the crystal structure of MYO7A MyTH4-FERM domains in complex with the central domain (CEN) of Sans at 2.8 angstrom resolution. The MyTH4 and FERM domains form an integral structural and functional supramodule binding to two highly conserved segments (CEN1 and 2) of Sans. The MyTH4-FERM/CEN complex structure provides mechanistic explanations for known deafness-causing mutations in MYO7A MyTH4-FERM. The structure will also facilitate mechanistic and functional studies of MyTH4-FERM domains in other myosins.

75 FR 38721 - Safety Zone; Munising 4th of July Fireworks, South Bay, Lake Superior, Munising, MI

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-06

...-AA00 Safety Zone; Munising 4th of July Fireworks, South Bay, Lake Superior, Munising, MI AGENCY: Coast... portion of South Bay during the Munising 4th of July Fireworks display, July 4, 2010. This temporary... from hazards associated with the Munising 4th of July Fireworks display. Based on the explosive hazards...

75 FR 34379 - Safety Zone; Mackinac Island 4th of July Fireworks, Lake Huron, Mackinac Island, MI

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-17

...-AA00 Safety Zone; Mackinac Island 4th of July Fireworks, Lake Huron, Mackinac Island, MI AGENCY: Coast... of Lake Huron during the Mackinac Island 4th of July Fireworks display on July 4, 2010. This... and vessels during the setup, and launching of fireworks in conjunction with the Mackinac Island 4th...

75 FR 34374 - Safety Zone; Stockton Ports Baseball Club/City of Stockton, 4th of July Fireworks Display...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-17

...-AA00 Safety Zone; Stockton Ports Baseball Club/City of Stockton, 4th of July Fireworks Display... July 4th fireworks display. This safety zone is established to ensure the safety of participants and... will sponsor the Stockton Ports Baseball Club/City of Stockton 4th of July Fireworks Display on July 4...

Investigation of the therapeutic potential of N-acetyl cysteine and the tools used to define nigrostriatal degeneration in vivo

PubMed Central

Nouraei, Negin; Zarger, Lauren; Weilnau, Justin N.; Han, Jimin; Mason, Daniel M.; Leak, Rehana K.

2016-01-01

The glutathione precursor N-acetyl-L-cysteine (NAC) is currently being tested on Parkinson's patients for its neuroprotective properties. Our studies have shown that NAC can elicit protection in glutathione-independent manners in vitro. Thus, the goal of the present study was to establish an animal model of NAC-mediated protection in which to dissect the underlying mechanism. Mice were infused intrastriatally with the oxidative neurotoxicant 6-hydroxydopamine (6-OHDA; 4 μg) and administered NAC intraperitoneally (100 mg/kg). NAC-treated animals exhibited higher levels of the dopaminergic terminal marker tyrosine hydroxylase (TH) in the striatum 10d after 6-OHDA. As TH expression is subject to stress-induced modulation, we infused the tracer FluoroGold into the striatum to retrogradely label nigrostriatal projection neurons. As expected, nigral FluoroGold staining and cell counts of FluoroGold+ profiles were both more sensitive measures of nigrostriatal degeneration than measurements relying on TH alone. However, NAC failed to protect dopaminergic neurons 3 weeks following 6-OHDA, an effect verified by four measures: striatal TH levels, nigral TH levels, nigral TH+ cell counts, and nigral FluoroGold levels. Some degree of mild toxicity of FluoroGold and NAC was evident, suggesting that caution must be exercised when relying on FluoroGold as a neuron-counting tool and when designing experiments with long-term delivery of NAC—such as clinical trials on patients with chronic disorders. Finally, the strengths and limitations of the tools used to define nigrostriatal degeneration are discussed. PMID:26879220

Climate change and the Delta

USGS Publications Warehouse

Dettinger, Michael; Anderson, Jamie; Anderson, Michael L.; Brown, Larry R.; Cayan, Daniel; Maurer, Edwin P.

2016-01-01

Anthropogenic climate change amounts to a rapidly approaching, “new” stressor in the Sacramento–San Joaquin Delta system. In response to California’s extreme natural hydroclimatic variability, complex water-management systems have been developed, even as the Delta’s natural ecosystems have been largely devastated. Climate change is projected to challenge these management and ecological systems in different ways that are characterized by different levels of uncertainty. For example, there is high certainty that climate will warm by about 2°C more (than late-20th-century averages) by mid-century and about 4°C by end of century, if greenhouse-gas emissions continue their current rates of acceleration. Future precipitation changes are much less certain, with as many climate models projecting wetter conditions as drier. However, the same projections agree that precipitation will be more intense when storms do arrive, even as more dry days will separate storms. Warmer temperatures will likely enhance evaporative demands and raise water temperatures. Consequently, climate change is projected to yield both more extreme flood risks and greater drought risks. Sea level rise (SLR) during the 20th century was about 22cm, and is projected to increase by at least 3-fold this century. SLR together with land subsidence threatens the Delta with greater vulnerabilities to inundation and salinity intrusion. Effects on the Delta ecosystem that are traceable to warming include SLR, reduced snowpack, earlier snowmelt and larger storm-driven streamflows, warmer and longer summers, warmer summer water temperatures, and water-quality changes. These changes and their uncertainties will challenge the operations of water projects and uses throughout the Delta’s watershed and delivery areas. Although the effects of climate change on Delta ecosystems may be profound, the end results are difficult to predict, except that native species will fare worse than invaders. Successful preparation for the coming changes will require greater integration of monitoring, modeling, and decision making across time, variables, and space than has been historically normal.

75 FR 34639 - Safety Zone; Reedville July 4th Celebration, Cockrell's Creek, Reedville, VA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

...-AA00 Safety Zone; Reedville July 4th Celebration, Cockrell's Creek, Reedville, VA AGENCY: Coast Guard... Cockrell's Creek in the vicinity of Reedville, Virginia in support of the Reedville July 4th Celebration... notice of proposed rulemaking (NPRM) entitled Reedville July 4th Celebration, Cockrell's Creek, Reedville...

Velocity dispersions in galaxies: 1: The SO galaxy NGC 7332

NASA Technical Reports Server (NTRS)

Morton, D. C.; Chevalier, R. A.

1971-01-01

A Coude spectrum of the SO galaxy NGC 7332 with 0.9 A resolution from 4186 to 4364 A was obtained with the SEC vidicon television camera and the Hale telescope. Comparisons with spectra of G and K giant stars, numerically broadened for various Maxwellian velocity distributions, give a dispersion velocity in the line of sight of 160 + or - 20 km/sec with the best fit at G8III. The dispersion appears to be constant within + or - 35 km/sec out to 1.4 kpc (H = 100 km/sec/mpc). After correction for projection, the rotation curve has a slope of 0.16 km/sec/pc at the center and a velocity of 130 km/sec at 1.4 kpc where it is still increasing. For an estimated effective radius of 3.5 kpc enclosing half the light, the virial theorem gives a mass of 1.4 x 10 to the 11th power solar masses if the mass-to-light ratio is constant throughout the galaxy. The photographic luminosity is 8.3 x 10 to the 9th power solar luminosities so that the M/L ratio is 17.

Mechanical Engineering Senior Design Project Final Presentations | College

Science.gov Websites

Mechanical Engineering Senior Design Project Final Presentations December 7, 2015 Mechanical Engineering On Wednesday, Dec. 9th, the mechanical engineering senior design project final presentations will be made in and Steven Keller Objective: Design a temperature controlled unit that would cool and maintain a

Designing, Developing and Implementing WWW-Based Distance Learning.

ERIC Educational Resources Information Center

Riley, Peter C.

The rapid advancement of communication technologies is resulting in a wide array of design and development choices for distance learning projects. The 58th Special Operations Wing at Kirtland Air Force Base, New Mexico, is developing a prototype distance learning project designed to serve geographically separated learner populations. Project staff…

Highway for life demonstration project : LA 511 (70th Street). Research project capsule.

DOT National Transportation Integrated Search

2013-06-01

The Louisiana Department of Transportation and Development (LADOTD), : has been awarded a Highways for Life (HfL) grant to be used on the LA 511 : widening project in Caddo Parish. The LA 511 corridor is one of the busiest in the : Shreveport, Louisi...

75 FR 2541 - Environmental Impact Statements and Regulations; Availability of EPA Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-15

..., 158th Fighter Wing Vermont Air National Guard Project, Proposed Realignment of National Guard Avenue and... the preparing agency. EIS No. 20090401, ERP No. F-IBR-K39118-CA, Delta-Mendota Canal/ California... Delta-Mendota Water Authority Project, Central Valley Project, Alameda and San Joaquin Counties, CA...

Dectin-1 diversifies Aspergillus fumigatus–specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation

PubMed Central

Hohl, Tobias M.; Collins, Nichole; Leiner, Ingrid; Gallegos, Alena; Saijo, Shinobu; Coward, Jesse W.; Iwakura, Yoichiro

2011-01-01

Pulmonary infection of mice with Aspergillus fumigatus induces concurrent T helper type 1 (Th1) and Th17 responses that depend on Toll-like receptor/MyD88 and Dectin-1, respectively. However, the mechanisms balancing Th1 and Th17 CD4 T cell populations during infection remain incompletely defined. In this study, we show that Dectin-1 deficiency disproportionally increases Th1 responses and decreases Th17 differentiation after A. fumigatus infection. Dectin-1 signaling in A. fumigatus–infected wild-type mice reduces IFN-γ and IL-12p40 expression in the lung, thereby decreasing T-bet expression in responding CD4 T cells and enhancing Th17 responses. Absence of IFN-γ or IL-12p35 in infected mice or T-bet in responding CD4 T cells enhances Th17 differentiation, independent of Dectin-1 expression, in A. fumigatus–infected mice. Transient deletion of monocyte-derived dendritic cells also reduces Th1 and boosts Th17 differentiation of A. fumigatus–specific CD4 T cells. Our findings indicate that Dectin-1–mediated signals alter CD4 T cell responses to fungal infection by decreasing the production of IL-12 and IFN-γ in innate cells, thereby decreasing T-bet expression in A. fumigatus–specific CD4 T cells and enabling Th17 differentiation. PMID:21242294

77 FR 67834 - Notice of Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-14

... to assess the program model's effectiveness in meeting the intended objectives. Surveys are designed... FY2013 project will focus on rising 6th through 8th grade students. This clearance request pertains to the administration of parent surveys, youth surveys, and teacher focus groups. The data collected will...

Science--It's for the Birds!

ERIC Educational Resources Information Center

Treboniak, Lois; Jaworski, Mark

1995-01-01

Describes a project in which 7th and 8th grade students learned lasting lessons about habitat when they built nesting boxes and erected them in a local park. Students deepened their understanding of environmental issues and gained a sense of pride. Includes instructions for building nesting boxes. (NB)

SU-C-209-02: 3D Fluoroscopic Image Generation From Patient-Specific 4DCBCT-Based Motion Models Derived From Clinical Patient Images

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dhou, S; Cai, W; Hurwitz, M

Purpose: We develop a method to generate time varying volumetric images (3D fluoroscopic images) using patient-specific motion models derived from four-dimensional cone-beam CT (4DCBCT). Methods: Motion models are derived by selecting one 4DCBCT phase as a reference image, and registering the remaining images to it. Principal component analysis (PCA) is performed on the resultant displacement vector fields (DVFs) to create a reduced set of PCA eigenvectors that capture the majority of respiratory motion. 3D fluoroscopic images are generated by optimizing the weights of the PCA eigenvectors iteratively through comparison of measured cone-beam projections and simulated projections generated from the motionmore » model. This method was applied to images from five lung-cancer patients. The spatial accuracy of this method is evaluated by comparing landmark positions in the 3D fluoroscopic images to manually defined ground truth positions in the patient cone-beam projections. Results: 4DCBCT motion models were shown to accurately generate 3D fluoroscopic images when the patient cone-beam projections contained clearly visible structures moving with respiration (e.g., the diaphragm). When no moving anatomical structure was clearly visible in the projections, the 3D fluoroscopic images generated did not capture breathing deformations, and reverted to the reference image. For the subset of 3D fluoroscopic images generated from projections with visibly moving anatomy, the average tumor localization error and the 95th percentile were 1.6 mm and 3.1 mm respectively. Conclusion: This study showed that 4DCBCT-based 3D fluoroscopic images can accurately capture respiratory deformations in a patient dataset, so long as the cone-beam projections used contain visible structures that move with respiration. For clinical implementation of 3D fluoroscopic imaging for treatment verification, an imaging field of view (FOV) that contains visible structures moving with respiration should be selected. If no other appropriate structures are visible, the images should include the diaphragm. This project was supported, in part, through a Master Research Agreement with Varian Medical Systems, Inc, Palo Alto, CA.« less

MO-G-17A-07: Improved Image Quality in Brain F-18 FDG PET Using Penalized-Likelihood Image Reconstruction Via a Generalized Preconditioned Alternating Projection Algorithm: The First Patient Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmidtlein, CR; Beattie, B; Humm, J

2014-06-15

Purpose: To investigate the performance of a new penalized-likelihood PET image reconstruction algorithm using the 1{sub 1}-norm total-variation (TV) sum of the 1st through 4th-order gradients as the penalty. Simulated and brain patient data sets were analyzed. Methods: This work represents an extension of the preconditioned alternating projection algorithm (PAPA) for emission-computed tomography. In this new generalized algorithm (GPAPA), the penalty term is expanded to allow multiple components, in this case the sum of the 1st to 4th order gradients, to reduce artificial piece-wise constant regions (“staircase” artifacts typical for TV) seen in PAPA images penalized with only the 1stmore » order gradient. Simulated data were used to test for “staircase” artifacts and to optimize the penalty hyper-parameter in the root-mean-squared error (RMSE) sense. Patient FDG brain scans were acquired on a GE D690 PET/CT (370 MBq at 1-hour post-injection for 10 minutes) in time-of-flight mode and in all cases were reconstructed using resolution recovery projectors. GPAPA images were compared PAPA and RMSE-optimally filtered OSEM (fully converged) in simulations and to clinical OSEM reconstructions (3 iterations, 32 subsets) with 2.6 mm XYGaussian and standard 3-point axial smoothing post-filters. Results: The results from the simulated data show a significant reduction in the 'staircase' artifact for GPAPA compared to PAPA and lower RMSE (up to 35%) compared to optimally filtered OSEM. A simple power-law relationship between the RMSE-optimal hyper-parameters and the noise equivalent counts (NEC) per voxel is revealed. Qualitatively, the patient images appear much sharper and with less noise than standard clinical images. The convergence rate is similar to OSEM. Conclusions: GPAPA reconstructions using the 1{sub 1}-norm total-variation sum of the 1st through 4th-order gradients as the penalty show great promise for the improvement of image quality over that currently achieved with clinical OSEM reconstructions.« less

Bigelow Expandable Activity Module (BEAM) Monitoring System

NASA Technical Reports Server (NTRS)

Wells, Nathan

2017-01-01

What is Bigelow Expandable Activity Module (BEAM)? The Bigelow Expandable Activity Module (BEAM) is an expandable habitat technology demonstration on ISS; increase human-rated inflatable structure Technology Readiness Level (TRL) to level 9. NASA managed ISS payload project in partnership with Bigelow Aerospace. Launched to ISS on Space X 8 (April 8th, 2016). Fully expanded on May 28th, 2016. Jeff Williams/Exp. 48 Commander first entered BEAM on June 5th, 2016.

The Initiative in the Human Microbiome and Infectious Diseases

DTIC Science & Technology

2015-12-01

DL. 2014. Interactions between the intestinal microbiota and innate lymphoid cells . Gut Microbes 5:129-140. 14. Erturk-Hasdemir D, Kasper DL. 2013...of intestinal T- cells , and in particular up-regulate Th17 cells in the gastrointestinal tract. In year 3 of the project, we have finished our...affecting the balance of IL-17-producing T helper (Th17) cells (15). Commensal bacteria are required for induction of Th17 cells ; acquisition of

75 FR 35649 - Safety Zone; Northern California Annual Fireworks Events, July 4th Fireworks Display

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-23

... Zone; Northern California Annual Fireworks Events, July 4th Fireworks Display AGENCY: Coast Guard, DHS. ACTION: Notice of enforcement of regulation. SUMMARY: The Coast Guard will enforce the Tahoe City 4th of... safety zone for the annual Tahoe City 4th of July Fireworks in 33 CFR 165.1191 on July 4, 2010, from 9 a...

Improving 6th Grade Climate Literacy using New Media (CLINM) and Teacher Professional Development

NASA Astrophysics Data System (ADS)

Smith, G.; Schmidt, C.; Metzger, E. P.; Cordero, E. C.

2012-12-01

The NASA-funded project, Improving 6th Grade Climate Literacy using New Media (CLINM), is designed to improve the climate literacy of California's 450,000 6th-grade students through teacher professional development that presents climate change as an engaging context for teaching earth science standards. The project fosters experience-based interaction among learners and encourages expressive creativity and idea-exchange via the web and social media. The heart of the CLINM project is the development of an online educator-friendly experience that provides content expert-reviewed, teacher-tested, standards-based educational resources, classroom activities and lessons that make meaningful connections to NASA data and images as well as new media tools (videos, web, and phone applications) based on the Green Ninja, a climate-action superhero who fights global warming by inspiring personal action (www.greenninja.info). In this session, we will discuss this approach to professional development and share a collection of teacher-tested CLINM resources. CLINM resources are grounded in earth system science; classroom activities and lessons engage students in exploration of connections between natural systems and human systems with a particular focus on how climate change relates to everyone's need for food, water, and energy. CLINM uses a team-based approach to resource development, and partners faculty in San José State University's (SJSU) colleges of Science, Education, and Humanities and the Arts with 6th-grade teachers from local school districts, a scientist from NASA Ames Research Center and climate change education projects at Stanford University, the University of Nebraska at Lincoln, and the University of Idaho. Climate scientists and other content experts identify relevant concepts and work with science educators to develop and/or refine classroom activities to elucidate those concepts; activities are piloted in pre-service science methods courses at SJSU and in teacher professional development workshops offered through the Bay Area Earth Science Institute (BAESI); workshop attendees frame the activities as lessons appropriate for their 6th grade students; participants who use the lessons and resources in their classrooms provide iterative feedback, which is used to improve the resources for other teachers involved in the project.

76 FR 37650 - Safety Zone; 4th of July Festival Berkeley Marina Fireworks Display Berkeley, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-28

...-AA00 Safety Zone; 4th of July Festival Berkeley Marina Fireworks Display Berkeley, CA AGENCY: Coast... the 4th of July Festival Berkeley Marina Fireworks Display. Unauthorized persons or vessels are... display. Background and Purpose The City of Berkeley Marina will sponsor the 4th of July Festival Berkeley...

75 FR 26157 - Safety Zone; Reedville July 4th Celebration, Cockrell's Creek, Reedville, VA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

...-AA00 Safety Zone; Reedville July 4th Celebration, Cockrell's Creek, Reedville, VA AGENCY: Coast Guard... Reedville July 4th Celebration event. This action is intended to restrict vessel traffic movement on... established in the interest of public safety during the Reedville July 4th Celebration event and will be...

75 FR 35294 - Safety Zone; Marquette 4th of July Fireworks, Marquette Harbor, Lake Superior, Marquette, MI

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-22

...-AA00 Safety Zone; Marquette 4th of July Fireworks, Marquette Harbor, Lake Superior, Marquette, MI... vessels from a portion of Marquette Harbor during the Marquette 4th of July Fireworks display. This... vessels during the setup and launching of fireworks in conjunction with the Marquette 4th of July...

75 FR 34636 - Safety Zone; Jameson Beach 4th of July Fireworks Display

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

...-AA00 Safety Zone; Jameson Beach 4th of July Fireworks Display AGENCY: Coast Guard, DHS. ACTION... waters of Lake Tahoe, for the Jameson Beach 4th of July Fireworks Display. This safety zone is... Safety Zone; Jameson Beach 4th of July Fireworks Display. (a) Location. This temporary safety zone is...

Glycogen Synthase Kinase-3 Is an Early Determinant in the Differentiation of Pathogenic Th17 Cells

PubMed Central

Beurel, Eléonore; Yeh, Wen-I; Michalek, Suzanne M.; Harrington, Laurie E.; Jope, Richard S.

2011-01-01

CD4+ T cells are critical for host defense but are also major drivers of immune-mediated diseases. The classical view of Th1 and Th2 subtypes of CD4+ T cells was recently revised by the identification of the Th17 lineage of CD4+ T cells that produce IL-17, which have been found to be critical in the pathogenesis of autoimmune and other diseases. Mechanisms controlling the differentiation of Th17 cells have been well described, but few feasible targets for therapeutically reducing Th17 cells are known. The generation of Th17 cells requires IL-6 and activation of STAT3. During polarization of CD4+ T cells to Th17 cells, we found that inhibition of glycogen synthase kinase-3 (GSK3) blocked IL-6 production, STAT3 activation, and polarization to Th17 cells. Polarization of CD4+ T cells to Th17 cells increased by 10-fold the expression of GSK3β protein levels in Th17 cells, whereas GSK3β was unaltered in regulatory T cells. Diminishing GSK3 activity either pharmacologically or molecularly blocked Th17 cell production, and increasing GSK3 activity promoted polarization to Th17 cells. In vivo inhibition of GSK3 in mice depleted constitutive Th17 cells in intestinal mucosa, blocked Th17 cell generation in the lung after Francisella tularensis infection, and inhibited the increase in spinal cord Th17 cells and disease symptoms in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. These findings identify GSK3 as a critical mediator of Th17 cell production and indicate that GSK3 inhibitors provide a potential therapeutic intervention to control Th17-mediated diseases. PMID:21191064

Thermodynamic assessment of the LiF-ThF4-PuF3-UF4 system

NASA Astrophysics Data System (ADS)

Capelli, E.; Beneš, O.; Konings, R. J. M.

2015-07-01

The LiF-ThF4-PuF3-UF4 system is the reference salt mixture considered for the Molten Salt Fast Reactor (MSFR) concept started with PuF3. In order to obtain the complete thermodynamic description of this quaternary system, two binary systems (ThF4-PuF3 and UF4-PuF3) and two ternary systems (LiF-ThF4-PuF3 and LiF-UF4-PuF3) have been assessed for the first time. The similarities between CeF3/PuF3 and ThF4/UF4 compounds have been taken into account for the presented optimization as well as in the experimental measurements performed, which have confirmed the temperatures predicted by the model. Moreover, the experimental results and the thermodynamic database developed have been used to identify potential compositions for the MSFR fuel and to evaluate the influence of partial substitution of ThF4 by UF4 in the salt.

19 CFR 12.104g - Specific items or categories designated by agreements or emergency actions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... representing the Byzantine period ranging from approximately the 4th century A.D. through approximately the... Byzantine culture (approximately the 4th century through the 15th century A.D.) CBP Dec. 11-25 Guatemala... periods ranging approximately from the 9th century B.C. to the 4th century A.D. T.D. 01-06 extended by CBP...

Differential effects of HIV transmission from monocyte-derived dendritic cells vs. monocytes to IL-17+CD4+ T cells

PubMed Central

Mitsuki, Yu-ya; Tuen, Michael; Hioe, Catarina E.

2017-01-01

HIV infection leads to CD4 helper T cell (Th) loss, but not all Th cells are equally depleted. The contribution of other immune cells in the Th depletion also remains unclear. This study investigates HIV transmission from monocyte-derived dendritic cells (MDDCs) vs. monocytes to Th17 and Th1 cells using an allogeneic coculture model. The addition of HIV to MDDCs increased the expression of the negative regulatory molecule PD-L1 and decreased the expression of the activation markers HLA-DR and CD86, whereas the virus up-regulated HLA-DR and CD86, but not PD-L1, on monocytes. Coculturing of CD4+ T cells with MDDCs pretreated with HIV led to the decline of Th17, but not Th1, responses. In contrast, pretreatment of monocytes with HIV increased Th17 without affecting Th1 responses. The enhanced Th17 responses in the cocultures with HIV-treated monocytes were also accompanied by high numbers of virus-infected CD4+ T cells. The Th17 expansion arose from memory CD4+ T cells with minimal contribution from naïve CD4+ T cells. The Th17-enhancing activity was mediated by the HIV envelope and did not require productive virus infection. Comparison of MDDCs and monocytes further showed that, although HIV-treated MDDCs reduced Th proliferation and increased the activation of the apoptosis mediator caspase-3, HIV-treated monocytes enhanced Th proliferation without increasing the active caspase-3 levels. This study indicates the potential role of distinct myeloid cell populations in shaping Th17 responses during HIV infection. PMID:27531931

A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models.

PubMed

Chen, Q; Muramoto, K; Masaaki, N; Ding, Y; Yang, H; Mackey, M; Li, W; Inoue, Y; Ackermann, K; Shirota, H; Matsumoto, I; Spyvee, M; Schiller, S; Sumida, T; Gusovsky, F; Lamphier, M

2010-05-01

Rheumatoid arthritis (RA) is an autoimmune disorder involving subsets of activated T cells, in particular T helper (Th) 1 and Th17 cells, which infiltrate and damage tissues and induce inflammation. Prostaglandin E(2) (PGE(2)) enhances the Th17 response, exacerbates collagen-induced arthritis (CIA) and promotes inflammatory pain. The current study investigated whether selective antagonism of the PGE(2) EP(4) receptor would suppress Th1/Th17 cell development and inflammatory arthritis in animal models of RA. Effects of PGE(2) and a novel EP(4) receptor antagonist ER-819762 on Th1 differentiation, interleukin-23 (IL-23) production by dendritic cells (DCs), and Th17 development were assessed in vitro. The effect of ER-819762 was evaluated in CIA and glucose-6-phosphate isomerase (GPI)-induced arthritis models. In addition, the effects of ER-819762 on pain were evaluated in a model of chronic inflammatory pain induced by complete Freund's adjuvant (CFA) in the rat. Stimulation of the EP(4) receptor enhanced Th1 differentiation via phosphatidylinositol 3 kinase signalling, selectively promoted Th17 cell expansion, and induced IL-23 secretion by activated DCs, effects suppressed by ER-819762 or anti-PGE(2) antibody. Oral administration of ER-19762 suppressed Th1 and Th17 cytokine production, suppressed disease in collagen- and GPI-induced arthritis in mice, and suppressed CFA-induced inflammatory pain in rats. PGE(2) stimulates EP(4) receptors to promote Th1 differentiation and Th17 expansion and is critically involved in development of arthritis in two animal models. Selective suppression of EP(4) receptor signalling may have therapeutic value in RA both by modifying inflammatory arthritis and by relieving pain.

Exciting Normal Distribution

ERIC Educational Resources Information Center

Fuchs, Karl Josef; Simonovits, Reinhard; Thaller, Bernd

2008-01-01

This paper describes a high school project where the mathematics teaching and learning software M@th Desktop (MD) based on the Computer Algebra System Mathematica was used for symbolical and numerical calculations and for visualisation. The mathematics teaching and learning software M@th Desktop 2.0 (MD) contains the modules Basics including tools…

Assessing Creative Thinking in Design-Based Learning

ERIC Educational Resources Information Center

Doppelt, Yaron

2009-01-01

Infusing creative thinking competence through the design process of authentic projects requires not only changing the teaching methods and learning environment, but also adopting new assessment methods, such as portfolio assessment. The participants in this study were 128 high school pupils who have studied MECHATRONICS from 10th to 12th grades…

Expanding Thorium Hydride Chemistry Through Th²⁺, Including the Synthesis of a Mixed-Valent Th⁴⁺/Th³⁺ Hydride Complex.

PubMed

Langeslay, Ryan R; Fieser, Megan E; Ziller, Joseph W; Furche, Filipp; Evans, William J

2016-03-30

The reactivity of the recently discovered Th(2+) complex [K(18-crown-6)(THF)2][Cp″3Th], 1 [Cp'' = C5H3(SiMe3)2-1,3], with hydrogen reagents has been investigated and found to provide syntheses of new classes of thorium hydride compounds. Complex 1 reacts with [Et3NH][BPh4] to form the terminal Th(4+) hydride complex Cp″3ThH, 2, a reaction that formally involves a net two-electron reduction. Complex 1 also reacts in the solid state and in solution with H2 to form a mixed-valent bimetallic product, [K(18-crown-6)(Et2O)][Cp″2ThH2]2, 3, which was analyzed by X-ray crystallography, electron paramagnetic resonance and optical spectroscopy, and density functional theory. The existence of 3, which formally contains Th(3+) and Th(4+), suggested that KC8 could reduce [(C5Me5)2ThH2]2. In the presence of 18-crown-6, this reaction forms an analogous mixed-valent product formulated as [K(18-crown-6)(THF)][(C5Me5)2ThH2]2, 4. A similar complex with (C5Me4H)(1-) ligands was not obtained, but reaction of (C5Me4H)3Th with H2 in the presence of KC8 and 2.2.2-cryptand at -45 °C produced two monometallic hydride products, namely, (C5Me4H)3ThH, 5, and [K(2.2.2-cryptand)]{(C5Me4H)2[η(1):η(5)-C5Me3H(CH2)]ThH]}, 6. Complex 6 contains a metalated tetramethylcyclopentadienyl dianion, [C5Me3H(CH2)](2-), that binds in a tuck-in mode.

Reassessment of 20th century global mean sea level rise.

PubMed

Dangendorf, Sönke; Marcos, Marta; Wöppelmann, Guy; Conrad, Clinton P; Frederikse, Thomas; Riva, Riccardo

2017-06-06

The rate at which global mean sea level (GMSL) rose during the 20th century is uncertain, with little consensus between various reconstructions that indicate rates of rise ranging from 1.3 to 2 mm⋅y -1 Here we present a 20th-century GMSL reconstruction computed using an area-weighting technique for averaging tide gauge records that both incorporates up-to-date observations of vertical land motion (VLM) and corrections for local geoid changes resulting from ice melting and terrestrial freshwater storage and allows for the identification of possible differences compared with earlier attempts. Our reconstructed GMSL trend of 1.1 ± 0.3 mm⋅y -1 (1σ) before 1990 falls below previous estimates, whereas our estimate of 3.1 ± 1.4 mm⋅y -1 from 1993 to 2012 is consistent with independent estimates from satellite altimetry, leading to overall acceleration larger than previously suggested. This feature is geographically dominated by the Indian Ocean-Southern Pacific region, marking a transition from lower-than-average rates before 1990 toward unprecedented high rates in recent decades. We demonstrate that VLM corrections, area weighting, and our use of a common reference datum for tide gauges may explain the lower rates compared with earlier GMSL estimates in approximately equal proportion. The trends and multidecadal variability of our GMSL curve also compare well to the sum of individual contributions obtained from historical outputs of the Coupled Model Intercomparison Project Phase 5. This, in turn, increases our confidence in process-based projections presented in the Fifth Assessment Report of the Intergovernmental Panel on Climate Change.

Reassessment of 20th century global mean sea level rise

PubMed Central

Dangendorf, Sönke; Marcos, Marta; Wöppelmann, Guy; Conrad, Clinton P.; Frederikse, Thomas; Riva, Riccardo

2017-01-01

The rate at which global mean sea level (GMSL) rose during the 20th century is uncertain, with little consensus between various reconstructions that indicate rates of rise ranging from 1.3 to 2 mm⋅y−1. Here we present a 20th-century GMSL reconstruction computed using an area-weighting technique for averaging tide gauge records that both incorporates up-to-date observations of vertical land motion (VLM) and corrections for local geoid changes resulting from ice melting and terrestrial freshwater storage and allows for the identification of possible differences compared with earlier attempts. Our reconstructed GMSL trend of 1.1 ± 0.3 mm⋅y−1 (1σ) before 1990 falls below previous estimates, whereas our estimate of 3.1 ± 1.4 mm⋅y−1 from 1993 to 2012 is consistent with independent estimates from satellite altimetry, leading to overall acceleration larger than previously suggested. This feature is geographically dominated by the Indian Ocean–Southern Pacific region, marking a transition from lower-than-average rates before 1990 toward unprecedented high rates in recent decades. We demonstrate that VLM corrections, area weighting, and our use of a common reference datum for tide gauges may explain the lower rates compared with earlier GMSL estimates in approximately equal proportion. The trends and multidecadal variability of our GMSL curve also compare well to the sum of individual contributions obtained from historical outputs of the Coupled Model Intercomparison Project Phase 5. This, in turn, increases our confidence in process-based projections presented in the Fifth Assessment Report of the Intergovernmental Panel on Climate Change. PMID:28533403

Good practices : incorporating safety into resurfacing and restoration projects

DOT National Transportation Integrated Search

2006-12-01

Integrating safety improvements into resurfacing and restoration projects is a subject of long-standing interest by Federal, State, and local transportation agencies. A Scan Tour was conducted to identify and subsequently observe good practices in th...

Priority technique for general aviation airport investments in Tennessee

DOT National Transportation Integrated Search

1999-01-01

One issue state departments of transportation must address is the allocation of funds among competing general aviation airport projects. For example, the Tennessee Aeronautics Division administers an annual program for funding projects at airports th...

Public-private partnerships potential for Arizona-Mexico border infrastructure projects.

DOT National Transportation Integrated Search

2009-09-01

This study of the PublicPrivate Partnership Potential for ArizonaMexico Border Infrastructure Projects originated as an action item of the Transportation, Infrastructure, and Ports Committee of the ArizonaMexico Commission. The purpose of th...

Northeast Florida rural transit intelligent transportation system (ITS) : evaluation plan

DOT National Transportation Integrated Search

2001-05-01

The Northeast Florida Rural Transportation Intelligent Transportation System (ITS) project is a demonstration of ITS deployment in five rural Community Transportation Coordinator (CTC) agencies. The objective of the project is to test and evaluate th...

Catecholaminergic connectivity to the inner ear, central auditory and vocal motor circuitry in the plainfin midshipman fish, Porichthys notatus

PubMed Central

Forlano, Paul M.; Kim, Spencer D.; Krzyminska, Zuzanna M.; Sisneros, Joseph A.

2014-01-01

Although the neuroanatomical distribution of catecholaminergic (CA) neurons has been well documented across all vertebrate classes, few studies have examined CA connectivity to physiologically and anatomically identified neural circuitry that controls behavior. The goal of this study was to characterize CA distribution in the brain and inner ear of the plainfin midshipman fish (Porichthys notatus) with particular emphasis on their relationship with anatomically labeled circuitry that both produces and encodes social acoustic signals in this species. Neurobiotin labeling of the main auditory endorgan, the saccule, combined with tyrosine hydroxylase immunofluorescence (TH-ir) revealed a strong CA innervation of both the peripheral and central auditory system. Diencephalic TH-ir neurons in the periventricular posterior tuberculum, known to be dopaminergic, send ascending projections to the ventral telencephalon and prominent descending projections to vocal-acoustic integration sites, notably the hindbrain octavolateralis efferent nucleus, as well as onto the base of hair cells in the saccule via nerve VIII. Neurobiotin backfills of the vocal nerve in combination with TH-ir revealed CA terminals on all components of the vocal pattern generator which appears to largely originate from local TH-ir neurons but may include diencephalic projections as well. This study provides strong evidence for catecholamines as important neuromodulators of both auditory and vocal circuitry and acoustic-driven social behavior in midshipman fish. This first demonstration of TH-ir terminals in the main endorgan of hearing in a non-mammalian vertebrate suggests a conserved and important anatomical and functional role for dopamine in normal audition. PMID:24715479

Colliding Winds and Tomography of O-Type Binaries

NASA Technical Reports Server (NTRS)

Gies, Dougles R.

1995-01-01

This grant was awarded in support of an observational study with the NASA IUE Observatory during the 15th episode (1992), and it subsequently also supported our continuing work in 16th (1994) and 18th (1995) episodes. The project involved the study of FUV spectra of massive spectroscopic binary systems containing hot stars of spectral type O. We applied a Doppler tomography algorithm to reconstruct the individual component UV spectra of stars in order to obtain improved estimates of the temperature, gravity, UV intensity ratio, and projected rotational velocity for stars in each system, and to make a preliminary survey for abundance anomalies through comparison with standard spectra. We also investigated the orbital phase-related variations in the UV stellar wind lines to probe the geometries of wind-wind collisions in these systems. The project directly supported two Ph.D. dissertations at Georgia State University (by Penny and Thaller), and we are grateful for this support. No inventions were made in the performance of this work. Detailed results are summarized in the abstracts listed in the following section.

Development and comparison of metrics for evaluating climate models and estimation of projection uncertainty

NASA Astrophysics Data System (ADS)

Ring, Christoph; Pollinger, Felix; Kaspar-Ott, Irena; Hertig, Elke; Jacobeit, Jucundus; Paeth, Heiko

2017-04-01

The COMEPRO project (Comparison of Metrics for Probabilistic Climate Change Projections of Mediterranean Precipitation), funded by the Deutsche Forschungsgemeinschaft (DFG), is dedicated to the development of new evaluation metrics for state-of-the-art climate models. Further, we analyze implications for probabilistic projections of climate change. This study focuses on the results of 4-field matrix metrics. Here, six different approaches are compared. We evaluate 24 models of the Coupled Model Intercomparison Project Phase 3 (CMIP3), 40 of CMIP5 and 18 of the Coordinated Regional Downscaling Experiment (CORDEX). In addition to the annual and seasonal precipitation the mean temperature is analysed. We consider both 50-year trend and climatological mean for the second half of the 20th century. For the probabilistic projections of climate change A1b, A2 (CMIP3) and RCP4.5, RCP8.5 (CMIP5,CORDEX) scenarios are used. The eight main study areas are located in the Mediterranean. However, we apply our metrics to globally distributed regions as well. The metrics show high simulation quality of temperature trend and both precipitation and temperature mean for most climate models and study areas. In addition, we find high potential for model weighting in order to reduce uncertainty. These results are in line with other accepted evaluation metrics and studies. The comparison of the different 4-field approaches reveals high correlations for most metrics. The results of the metric-weighted probabilistic density functions of climate change are heterogeneous. We find for different regions and seasons both increases and decreases of uncertainty. The analysis of global study areas is consistent with the regional study areas of the Medeiterrenean.

Effectiveness of oxfendazole against early and later 4th-stage Strongylus vulgaris in ponies.

PubMed

Slocombe, J O; McCraw, B M; Pennock, P; Ducharme, N G; Baird, J D

1986-03-01

Twenty pony foals (reared worm free), 6.5 to 10 weeks of age, were inoculated with Strongylus vulgaris and allocated to 5 groups, each with 4 foals. One week after inoculation, 1 group of 4 foals was given oxfendazole (OFZ) at a dosage rate of 10 mg/kg of body weight, another group was given 2 such treatments 48 hours apart, and a 3rd group was given a placebo. All treatments were administered by stomach tube. Three weeks later, foals were euthanatized and necropsied in a test for efficacy against early 4th-stage larvae. Oxfendazole was 80% and 94.9% effective against early 4th-stage S vulgaris with 1 and 2 doses, respectively. A 4th group of 4 foals was given 2 treatments of OFZ, 48 hours apart, about 8 weeks after inoculation, and a 5th group was given a placebo. These foals were euthanatized and necropsied 5 weeks after treatment in a test for efficacy against later 4th-stage larvae. Two doses of OFZ were 96.6% effective against later 4th-stage larvae.

77 FR 40266 - Safety Zone; Conneaut 4th of July Festival, Lake Erie, Conneaut, OH

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-09

... 1625-AA00 Safety Zone; Conneaut 4th of July Festival, Lake Erie, Conneaut, OH AGENCY: Coast Guard, DHS... the Conneaut 4th of July Festival Fireworks display. This temporary safety zone is necessary to... vessels during the Conneaut 4th of July Festival Fireworks. This zone will be effective and enforced from...

77 FR 30242 - Safety Zone; City of Tonawanda July 4th Celebration, Niagara River, Tonawanda, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-22

...-AA00 Safety Zone; City of Tonawanda July 4th Celebration, Niagara River, Tonawanda, NY AGENCY: Coast... vessels from a portion of the Niagara River during the City of Tonawanda July 4th Celebration fireworks... read as follows: Sec. 165.T09-0352 Safety Zone; City of Tonawanda July 4th Celebration, Niagara River...

77 FR 39172 - Safety Zone: Skagway Harbor, Skagway, AK for 4th of July Fireworks

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-02

...-AA00 Safety Zone: Skagway Harbor, Skagway, AK for 4th of July Fireworks AGENCY: Coast Guard, DHS... of the Small Boat Harbor, Skagway, Alaska, to limit access for the duration of the 4th of July... Inlet for the City of Skagway, Alaska, sponsored 4th of July fireworks display. A no-action alternative...

77 FR 39422 - Eighth Coast Guard District Annual Safety Zones; Niceville July 4th Fireworks Show; Boggy Bayou...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

...-AA00 Eighth Coast Guard District Annual Safety Zones; Niceville July 4th Fireworks Show; Boggy Bayou... Guard will enforce a Safety Zone for the Niceville July 4th Fireworks Show in Boggy Bayou, Niceville... July 4th Fireworks Show. During the enforcement period, entry into, transiting or anchoring in the...

166. GENERAL VIEW DOWN 4TH AVENUE. VIEW NORTHEAST DOWN 4TH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

166. GENERAL VIEW DOWN 4TH AVENUE. VIEW NORTHEAST DOWN 4TH AVE. FROM BUILDING 44 SHOWING, FROM LEFT TO RIGHT, BUILDING 46, 48, 55, AND 50 (PART OF ENLISTED BARRACKS COMPLEX), AND BUILDINGS 17, 16, 484, 483, 374, AND 375 (IN THE WAREHOUSE COMPLEX). - Quonset Point Naval Air Station, Roger Williams Way, North Kingstown, Washington County, RI

Creating the Public Connection: Interactive Experiences with Real-Time Earth and Space Science Data

NASA Technical Reports Server (NTRS)

Reiff, Patricia H.; Ledley, Tamara S.; Sumners, Carolyn; Wyatt, Ryan

1995-01-01

The Houston Museum of Natural Sciences is less than two miles from Rice University, a major hub on the Internet. This project links these two institutions so that NASA real-time data and imagery can flow via Rice to the Museum where it reaches the public in the form of planetarium programs, computer based interactive kiosks, and space and Earth science problem solving simulation. Through this program at least 200,000 visitors annually (including every 4th and 7th grader in the Houston Independent School District) will have direct exposure to the Earth and space research being conducted by NASA and available over the Internet. Each information conduit established between Rice University and the Houston Museum of Natural Science will become a model for public information dissemination that can be replicated nationally in museums, planetariums, Challenger Centers, and schools.

XRF and micro-PIXE studies of inhomogeneity of ancient bronze and silver alloys

NASA Astrophysics Data System (ADS)

Vasilescu, A.; Constantinescu, B.; Stan, D.; Talmatchi, G.; Ceccato, D.

2017-09-01

New results regarding alloy composition and microstructure for a series of ancient bronze and silver items by X-ray Fluorescence and micro-Particle Induced X-ray Emission spectrometry were obtained in the framework of an extensive numismatic project (Scythian-type arrowheads, arrowhead-shaped monetary signs and wheel coins produced by Histria, 7th-4th century of BCE, and Dacian Radulesti-Hunedoara-type silver tetradrachms, 2nd-1st century of BCE). In Histria, warfare arrowheads were used for trade with Barbarian neighbors at first, then mechanically modified, next melted and cast as dedicated monetary signs, being, in the end, replaced by wheel coins. Three different types of alloys have been identified, and Cu-Mn and Cu-Pb segregation shown. In a blank for Radulesti-Hunedoara-type coins, Ag-(Cu+Pb) segregation has been demonstrated, suggesting an imperfectly alloyed silver-leaded bronze.

KSC-2009-2105

NASA Image and Video Library

2009-03-15

CAPE CANAVERAL, Fla. – In Firing Room 4 of the Launch Control Center at NASA's Kennedy Space Center in Florida, from left, Steve Stich, manager of the Kennedy Orbiter Project Office; John Fraser, with Boeing Co. at the Marshall Space Flight Center; Rick Russell, with the NASA Orbiter Sustaining Engineering Office; and Rene Ortega with Marshall Space Flight Center's Shuttle Propulsion Office, are presented with a plaque for their work on the fuel control valve problem on space shuttle Discovery. The award was presented after the successful launch of Discovery on the STS-119 mission. Liftoff was on time at 7:43 p. m. EDT. The STS-119 mission is the 28th to the space station and Discovery's 36th flight. Discovery will deliver the final pair of power-generating solar array wings and the S6 truss segment. Installation of S6 will signal the station's readiness to house a six-member crew for conducting increased science. Photo credit: NASA/Kim Shiflett

The risk of a second diagnostic window with 4th generation HIV assays: Two cases.

PubMed

Niederhauser, C; Ströhle, A; Stolz, M; Müller, F; Tinguely, C

2009-08-01

Despite the improved sensitivity of the 4th generation combined antigen/antibody HIV assays, detection of HIV in the early phase of an infection may still be ineffective. Description of two cases that highlight the existence of the "second diagnostic window phase" observed with commonly used sensitive 4th generation HIV assays. Samples were screened with different 4th generation HIV assays. HIV infection was confirmed with an HIV I/II antibody assay, a HIV-1 p24 antigen assay, the INNO-LIA HIV I/II Score Line immunoassay and HIV-1 PCR. In both investigated cases, the limitations of the 4th generation HIV assays within the second diagnostic window were apparent. The overall sensitivity of the commercial 4th generation HIV assays is currently higher than the 3rd generation HIV assays. Nevertheless, the rare occurrence of a second diagnostic window with 4th generation HIV assays strongly suggests that the following up testing algorithms need to be adjusted accordingly.

Visual detection of driving while intoxicated. Project interim report : identification of visual cues and development of detection methods

DOT National Transportation Integrated Search

1979-01-01

The report describes the initial phase of a two-phase project on the visual, on-the-road detection of driving while intoxicated (DWI). The purpose of the overall project is to develop and test procedures for enhancing on-the-road detection of DWI. Th...

National evaluation of the FY 2003 Earmarked ITS Integration Project : Southern Wyoming, I-80 dynamic message signs, final phase III evaluation report.

DOT National Transportation Integrated Search

2010-12-01

This report presents the results for the national evaluation of the FY 2003 Earmarked ITS Integration Project: Southern Wyoming, I-80 Dynamic Message Signs. The I-80 Dynamic Message Signs project is a rural infrastructure deployment of ITS devices th...

Coexistence of Th1/Th2 and Th17/Treg imbalances in patients with allergic asthma.

PubMed

Shi, Yu-heng; Shi, Guo-chao; Wan, Huan-ying; Jiang, Li-hua; Ai, Xiang-yan; Zhu, Hai-xing; Tang, Wei; Ma, Jia-yun; Jin, Xiao-yan; Zhang, Bo-ying

2011-07-05

Recent recognition is that Th2 response is insufficient to fully explain the aetiology of asthma. Other CD4(+) T cells subsets might play a role in asthma. We investigated the relative abundance and activities of Th1, Th2, Th17 and CD4(+)CD25(+) Treg cells in patients with allergic asthma. Twenty-two patients with mild asthma, 17 patients with moderate to severe asthma and 20 healthy donors were enrolled. All patients were allergic to house dust mites. Plasma total IgE, pulmonary function and Asthma Control Questionnaire were assessed. The proportions of peripheral blood Th1, Th2, Th17 and CD4(+)CD25(+) Treg cells were determined by flow cytometry. The expression of cytokines in plasma and in the culture supernatant of peripheral blood mononuclear cells was determined by enzyme linked, immunosorbent assay. The frequency of blood Th2 cells and IL-4 levels in plasma and culture supernatant of peripheral blood mononuclear cells were increased in all patients with allergic asthma. The frequency of Th17 cells and the plasma and culture supernatant levels of IL-17 were increased, whereas the frequency of CD4(+)CD25(+) Treg cells and plasma IL-10 levels were decreased in patients with moderate to severe asthma. Dermatophagoides pteronyssinus specific IgE levels were positively correlated with the percentage of blood Th2 cells and plasma IL-4 levels. Forced expiratory volume in the first second was negatively correlated with the frequency of Th17 cells and plasma IL-17 levels, and positively correlated with the frequency of Treg cells. However, mean Asthma Control Questionnaire scores were positively correlated with the frequency of Th17 cells and plasma IL-17 levels, and negatively correlated with the frequency of Treg cells. Imbalances in Th1/Th2 and Th17/Treg were found in patients with allergic asthma. Furthermore, elevated Th17 cell responses, the absence of Tregs and an imbalance in Th17/Treg levels were associated with moderate to severe asthma.

Interpretation of time series (salinity and temperature) layers in North Atlantic from 1950 to 2011

NASA Astrophysics Data System (ADS)

Rubchenia, A.; Popov, A.; Fedorova, A.; Lebedev, N.

2012-04-01

On the basis of long period data series (1950-2011) form various sources (National Oceanographic Data Center (NOAD) (www.nodc.noaa.gov), WOD09 database and data from ARGO project) 10 boxes in North Atlantic were selected. Location of boxes was determined by circulation pattern in North Atlantic and Euro-Arctic Seas. For further analysis two "seasons" was selected: "cold season" (October-May) and "warm season" (June-September). Data verification was made. Analysis of data series clearly show the "Great Salinity Anomaly" (so-called GSA) in 1960-70th, 1980th and 1990th. Trends of salinity and temperature data series were calculated. Spectral analysis allow us to calculate periodicity from 2 to 22 years. Boxes situated in regions with Arctic waters have singularity showed through domination of high frequency oscillation during propagation to South. In Fram Strait salinity fluctuates with periods 9..11 and 20 years, the same period was calculated using temperature data series. In Denmark Strait there are oscillations of temperature with specific period from 4 to 7 years. Range of variability vary. For salinity it is 0.4..4.6 psu, for temperature it is 0.04..5.5C. In salinity data series from boxes with surface Arctic waters noticed clear minimums connected with GSAs. Trends in Denmark Strait and Fram strait in the end of 2000th are negative at different levels. Since 1975 to 2001 salinity near the southern part of Greenland was increased, since 2001 - decreased. But temperature was raised from 0.04 in 1989 to 5.59 in 2010. Thermohaline characteristics of water masses which has Atlantic origin oscillated with period near 20 years. Salinity near Newfoundland was decreased since 2005. In Farrero-Shetland straits salinity trend is positive since at 100m level, Salinity rising from 1970th to 2006 is about 0.3 psu were noticed. Oscillations with period 2..4 years is weak. But at 800m layer salinity oscillations are different, since 1990 there is not significant oscillations at all. Temperature trend at this level is negative since 1950th. Salinity at 100-300 level at Station M area described with negative trend since 1960 to 1993, in both "seasons". Next, up to 2010 salinity is increasing, but in 2011 salinity dramatically decreased. Main oscillations have periods 2..3 years, 4..5 years and 20 years. At 800m level oscillations are very weak. Temperature is increased since 1995 in surface layer and since 2002 in deeper levels. At all levels temperature dramatically decreased after 2010. In central part of Greenland Sea ("Cupola area") dominated oscillations with period 4 years (1950-60th), 5..7 years (1970th) and 9 years (after 1979). In "cold season" oscillation with 11 years traced. Salinity trend is positive at all levels during last 10-15 years. Salinity and temperature were increased at 800m level up to 2006. It could lead to termination of deep water formation. Since 2006 temperature decreased, especially in "cold season". Salinity trend in West Spitsbergen Current is positive since 1996 at surface and sine 1978 at deeper levels. Temperature was increased since 1965 to 2006 in surface layer, but since 2006 in "warm season" temperature is decreasing at all layers. Main oscillations is 4..5 years, 6..7 years and 9..11 years.

Project CHECO Southeast Asia Report. Rolling Thunder

DTIC Science & Technology

1966-03-28

interdiction pro- grams. In February the USAF bad 18 F-100 ’s and 18 F-105 ’s at ))a Nang, 18 F-105’s at Korat , 18 F-lOO’s at Takhli and eight B-57’s at Bien...force back to its November 1964 strength. In Thailand, the F-105 squadron at Korat was joined in early February by two more squadrons of F-l.05’s, one...135) Ubon 45th Tactical Figbter Squadron Takhli 35th ’l."FS (F-105~ 563rd ’fFS (F-105 Korat 357th ’l."FS (F-105) 12th TJ’S (F-105) Udorn 15th

CCR6(+) Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis.

PubMed

Paulissen, Sandra M J; van Hamburg, Jan Piet; Davelaar, Nadine; Vroman, Heleen; Hazes, Johanna M W; de Jong, Pascal H P; Lubberts, Erik

2015-11-30

Patients with rheumatoid arthritis (RA) can be separated into two major subpopulations based on the absence or presence of serum anti-citrullinated protein antibodies (ACPAs). The more severe disease course in ACPA(+) RA and differences in treatment outcome between these subpopulations suggest that ACPA(+) and ACPA(-) RA are different disease subsets. The identification of T-helper (Th) cells specifically recognizing citrullinated peptides, combined with the strong association between HLA-DRB1 and ACPA positivity, point toward a pathogenic role of Th cells in ACPA(+) RA. In this context we recently identified a potential pathogenic role for CCR6(+) Th cells in RA. Therefore, we examined whether Th cell population distributions differ by ACPA status. We performed a nested matched case-control study including 27 ACPA(+) and 27 ACPA(-) treatment-naive early RA patients matched for disease activity score in 44 joints, presence of rheumatoid factor, sex, age, duration of complaints and presence of erosions. CD4(+)CD45RO(+) (memory) Th cell distribution profiles from these patients were generated based on differential chemokine receptor expression and related with disease duration. ACPA status was not related to differences in total CD4(+) T cell or memory Th cell proportions. However, ACPA(+) patients had significantly higher proportions of Th cells expressing the chemokine receptors CCR6 and CXCR3. Similar proportions of CCR4(+) and CCR10(+) Th cells were found. Within the CCR6(+) cell population, four Th subpopulations were distinguished based on differential chemokine receptor expression: Th17 (CCR4(+)CCR10(-)), Th17.1 (CXCR3(+)), Th22 (CCR4(+)CCR10(+)) and CCR4/CXCR3 double-positive (DP) cells. In particular, higher proportions of Th22 (p = 0.02), Th17.1 (p = 0.03) and CCR4/CXCR3 DP (p = 0.01) cells were present in ACPA(+) patients. In contrast, ACPA status was not associated with differences in Th1 (CCR6(-)CXCR3(+); p = 0.90), Th2 (CCR6(-)CCR4(+); p = 0.27) and T-regulatory (CD25(hi)FOXP3(+); p = 0.06) cell proportions. Interestingly, CCR6(+) Th cells were inversely correlated with disease duration in ACPA(-) patients (R(2) = -0.35; p < 0.01) but not in ACPA(+) (R(2) < 0.01; p = 0.94) patients. These findings demonstrate that increased peripheral blood CCR6(+) Th cells proportions distinguish ACPA(+) RA from ACPA(-) RA. This suggests that CCR6(+) Th cells are involved in the differences in disease severity and treatment outcome between ACPA(+) and ACPA(-) RA.

Knowledge barriers to PACS adoption and implementation in hospitals.

PubMed

Paré, Guy; Trudel, Marie-Claude

2007-01-01

Drawing on the classical theory of diffusion of innovations advanced by Rogers [E.M. Rogers, Diffusion of Innovations, 4th ed., Free Press, New York, NY, 1995] and on the theory of barriers to innovation [P. Attewell, Technology diffusion and organizational learning: the case of business computing. Organ. Sci. 3 (1992) 1-19; H. Tanriverdi, C.S. Iacono, Knowledge barriers to diffusion of telemedicine. Proceedings of the 20th International Conference on Information Systems, Charlotte, NC, 1999, pp. 39-50; S. Nambisan, Y.-M. Wang, Roadblocks to web technology adoption? Commun. ACM, 42 (1) (1999) 98-101], this study seeks a better understanding of challenges faced in PACS implementations in hospitals and of the strategies required to ensure their success. To attain this objective, we describe and analyze the process used to adopt and implement PACS at two Canadian hospitals. Our findings clearly demonstrate the importance of treating any PACS deployment not simply as a rollout of new technology but as a project that will transform the organization. Proponents of these projects must not lose sight of the fact that, even if technological complexity represents a significant issue, it must not garner all the project team's attention. This situation is even more dangerous, inasmuch as the greatest risk to the implementation often lies elsewhere. It would also appear to be crucial to anticipate and address organizational and behavioral challenges from the very first phase of the innovation process, in order to ensure that all participants will be committed to the project. In order to maximize the likelihood of PACS success, it appears crucial to adopt a proactive implementation strategy, one that takes into consideration all the technical, economic, organizational, and human factors, and does so from the first phase of the innovation process.

Past and ongoing shifts in Joshua tree distribution support future modeled range contraction

USGS Publications Warehouse

Cole, Kenneth L.; Ironside, Kirsten; Eischeid, Jon K.; Garfin, Gregg; Duffy, Phil; Toney, Chris

2011-01-01

The future distribution of the Joshua tree (Yucca brevifolia) is projected by combining a geostatistical analysis of 20th-century climates over its current range, future modeled climates, and paleoecological data showing its response to a past similar climate change. As climate rapidly warmed ;11 700 years ago, the range of Joshua tree contracted, leaving only the populations near what had been its northernmost limit. Its ability to spread northward into new suitable habitats after this time may have been inhibited by the somewhat earlier extinction of megafaunal dispersers, especially the Shasta ground sloth. We applied a model of climate suitability for Joshua tree, developed from its 20th-century range and climates, to future climates modeled through a set of six individual general circulation models (GCM) and one suite of 22 models for the late 21st century. All distribution data, observed climate data, and future GCM results were scaled to spatial grids of ;1 km and ;4 km in order to facilitate application within this topographically complex region. All of the models project the future elimination of Joshua tree throughout most of the southern portions of its current range. Although estimates of future monthly precipitation differ between the models, these changes are outweighed by large increases in temperature common to all the models. Only a few populations within the current range are predicted to be sustainable. Several models project significant potential future expansion into new areas beyond the current range, but the species' Historical and current rates of dispersal would seem to prevent natural expansion into these new areas. Several areas are predicted to be potential sites for relocation/ assisted migration. This project demonstrates how information from paleoecology and modern ecology can be integrated in order to understand ongoing processes and future distributions.

Final Scientific Report for "The Interhemispheric Pattern in 20th Century and Future Abrupt Change in Regional Tropical Rainfall"

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chiang, John C. H.; Wehner, Michael F.

2012-10-29

This is the final scientific report for grant DOE-FG02-08ER64588, "The Interhemispheric Pattern in 20th Century and Future Abrupt Change in Regional Tropical Rainfall."The project investigates the role of the interhemispheric pattern in surface temperature – i.e. the contrast between the northern and southern temperature changes – in driving rapid changes to tropical rainfall changes over the 20th century and future climates. Previous observational and modeling studies have shown that the tropical rainband – the Intertropical Convergence Zone (ITCZ) over marine regions, and the summer monsoonal rainfall over land – are sensitive to the interhemispheric thermal contrast; but that the linkmore » between the two has not been applied to interpreting long-term tropical rainfall changes over the 20th century and future.The specific goals of the project were to i) develop dynamical mechanisms to explain the link between the interhemispheric pattern to abrupt changes of West African and Asian monsoonal rainfall; ii) Undertake a formal detection and attribution study on the interhemispheric pattern in 20th century climate; and iii) assess the likelihood of changes to this pattern in the future. In line with these goals, our project has produced the following significant results: 1.We have developed a case that suggests that the well-known abrupt weakening of the West African monsoon in the late 1960s was part of a wider co-ordinated weakening of the West African and Asian monsoons, and driven from an abrupt cooling in the high latitude North Atlantic sea surface temperature at the same time. Our modeling work suggests that the high-latitude North Atlantic cooling is effective in driving monsoonal weakening, through driving a cooling of the Northern hemisphere that is amplified by positive radiative feedbacks. 2.We have shown that anthropogenic sulfate aerosols may have partially contributed to driving a progressively southward displacement of the Atlantic Intertropical Convergence Zone (ITCZ) over the course of the 20th century prior to the 1980s. This is based on our detection and attribution analysis of 20th century simulations done by international modeling groups as part of the Coupled Model Intercomparison Project phase 3 (CMIP3). We repeated the same analysis with the current CMIP5 multimodel simulations, with essentially similar results. 3.Future projections of the global interhemispheric thermal gradient suggest a pronounced trend that well exceeds the 20th century range of behavior. The major cause of this trend is due to anthropogenic greenhouse gas emissions, acting in such a way as to warm the North more than the South. This result is based on our analysis of the CMIP3 and 5 simulations of future scenarios. The underlying suggestion is that tropical rainfall may concentrate more northwards in the future climate, though further research is required to more firmly establish that result.Taken together, our results shows the important role of the interhemispheric thermal gradient in determining tropical rainfall changes in the 20th century and future. Our analysis specifically highlights high-latitude North Atlantic sea surface temperature, and anthropogenic sulfate aerosols, as important drivers of the interhemispheric gradient over the 20th century; and anthropogenic greenhouse gases in the 21st. The PI has written a review paper in order to promote the awareness of the interhemispheric gradient amongst the climate science community.Our project was instrumental in developing the career of a postdoctoral scholar, as well as contributing to the research training of three Ph.D. candidates.« less

Comparison of synchrotron radiation and conventional x-ray microcomputed tomography for assessing trabecular bone microarchitecture of human femoral heads

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chappard, Christine; Basillais, Armelle; Benhamou, Laurent

Microcomputed tomography ({mu}CT) produces three-dimensional (3D) images of trabecular bone. We compared conventional {mu}CT (C{mu}CT) with a polychromatic x-ray cone beam to synchrotron radiation (SR) {mu}CT with a monochromatic parallel beam for assessing trabecular bone microarchitecture of 14 subchondral femoral head specimens from patients with osteoarthritis (n=10) or osteoporosis (n=4). SR{mu}CT images with a voxel size of 10.13 {mu}m were reconstructed from 900 2D radiographic projections (angular step, 0.2 deg. ). C{mu}CT images with a voxel size of 10.77 {mu}m were reconstructed from 205, 413, and 825 projections obtained using angular steps of 0.9 deg., 0.45 deg., and 0.23 deg.,more » respectively. A single threshold was used to binarize the images. We computed bone volume/tissue volume (BV/TV), bone surface/bone volume (BS/BV), trabecular number (Tb.N), trabecular thickness (Tb.Th and Tb.Th*), trabecular spacing (Tb.Sp), degree of anisotropy (DA), and Euler density. With the 0.9 deg. angular step, all C{mu}CT values were significantly different from SR{mu}CT values. With the 0.23 deg. and 0.45 deg. rotation steps, BV/TV, Tb.Th, and BS/BV by C{mu}CT differed significantly from the values by SR{mu}CT. The error due to slice matching (visual site matching {+-}10 slices) was within 1% for most parameters. Compared to SR{mu}CT, BV/TV, Tb.Sp, and Tb.Th by C{mu}CT were underestimated, whereas Tb.N and Tb.Th* were overestimated. A Bland and Altman plot showed no bias for Tb.N or DA. Bias was -0.8{+-}1.0%, +5.0{+-}1.1 {mu}m, -5.9{+-}6.3 {mu}m, and -5.7{+-}29.1 {mu}m for BV/TV, Tb.Th*, Tb.Th, and Tb.Sp, respectively, and the differences did not vary over the range of values. Although systematic differences were noted between SR{mu}CT and C{mu}CT values, correlations between the techniques were high and the differences would probably not change the discrimination between study groups. C{mu}CT provides a reliable 3D assessment of human defatted bone when working at the 0.23 deg. or 0.45 deg. rotation step; the 0.9 deg. rotation step may be insufficiently accurate for morphological bone analysis.« less

Impacts of Parental Education on Substance Use: Differences among White, African-American, and Hispanic Students in 8th, 10th, and 12th Grades (1999-2008). Monitoring the Future Occasional Paper Series. Paper No. 70

ERIC Educational Resources Information Center

Bachman, Jerald G.; O'Malley, Patrick M.; Johnston, Lloyd D.; Schulenberg, John E.

2010-01-01

The Monitoring the Future (MTF) project reports annually on levels and trends in self-reported substance use by secondary school students (e.g., Johnston, O'Malley, Bachman, & Schulenberg, 2009). The reports include subgroup comparisons, and these have revealed substantial differences among race/ethnicity groups, as well as some differences…

Project VALOR: Trajectories of Change in PTSD in Combat-Exposed Veterans

DTIC Science & Technology

2016-10-01

Behavioral and Cognitive Therapy 50th Annual Meeting. New York, NY. Black, S. K., Erb, S. Green, J. D., Bovin, M., Sloan, D. M., & Marx, B. (November...reactivity and regulation in PTSD; Chair: K. McHugh) at the Association for Behavioral and Cognitive Therapies 49th Annual Meeting. Chicago, IL. Black, S. K...comparison of OIF deployment phases. Poster presented at the Association for Behavioral and Cognitive Therapies 49th Annual Meeting. Chicago, IL

The Army Image: In Need of Change

DTIC Science & Technology

2000-04-10

MMimmninniiinwiimMtitwiiii| 20000420 122 USAWC STRATEGY RESEARCH PROJECT The Army Image: In Need of Change? By Bertram B. Armstrong U.S. Army Barringer F... Bruce Patterson notes the negativity of U.S. newspaper headlines near the end of the American involvement in the Vietnam War: "NCO Club Scandal...1969- 1960 1970 96th 1979- 1980 -t-h- r - 101st 1989- 1990 A.* I I I I I 106th 1999- 2000 Congress Number and Years FIGURE 1

Atmospheric measurements of hydroperoxides and aldehydes during field campaigns : new results due to improvement of measurements techniques

NASA Astrophysics Data System (ADS)

François, S.; Sowka, I.; Poulain, L.; Monod, A.; Wortham, H.

2003-04-01

Hydroperoxides and aldehydes are considered as atmospheric reservoirs of OH, HO_2 and RO_2 radicals and can reflect the oxidizing levels of the atmosphere. They are considered as important gas phase photo-oxidants present in the atmosphere. However, the atmospheric role of these compounds can vary from one species to another, therefore it is essential to investigate their measurement and speciation in the atmosphere. Atmospheric measurements were realized during two different field campaigns in the Marseilles area (France). Hydroperoxides were trapped in aqueous phase, with a glass coil and analyzed by HPLC/fluorescence detector with post column derivatization. Aldehydes were trapped in a liquid phase containing 2-4 DNPH, with a mist chamber and analyzed by HPLC/UV. The analytical techniques provided individual separation and quantification of seven hydroperoxides (hydrogen peroxide, hydroxymethyl hydroperoxide, bis(hydroxymethyl) peroxide, 1-hydroxyethyl hydroperoxide, methyl hydroperoxide, ethyl hydroperoxide and peroxyacetic acid) and eleven volatile aldehydes (formaldehyde, acetaldehyde, acrolein, acetone, propionaldehyde, crotonaldehyde, butyraldehyde, benzaldehyde, glyoxal, valeraldehyde and methylglyoxal). The first field campaign was part of the ESCOMPTE project (June 4th to July 16th 2001). During this campaign five different sampling sites, at low altitudes (<= 285 m), were investigated (maritime, urban, sub-industrial, biogenic and rural sites) and atmospheric measurements were realized during photochemical air pollution events. The second field campaign was part of the BOND project (July 2nd to July 14th 2002). Atmospheric measurements of hydroperoxides were carried out on one biogenic site, at altitude 690 m. The measurement system was improved allowing online sampling and analysis. During these field campaigns collection efficiencies were better than 96% for hydroperoxides, and from 78% to 96% for aldehydes. Detection limits were between 7,3× 10-3 μg.m-3 and 2,4× 10-1 μg.m-3 with standard deviations from 4% to 22% for hydroperoxides and between 0,55 μg.m-3 and 2,5 μg.m-3 with standard deviation from 8% to 29% for aldehydes. The results show that hydroperoxide concentrations were high, when the levels of NOx were low. Aldehyde concentrations were very high during photochemical events and both primary and secondary aldehydes were identified.

Structure and Energetics of Clusters Relevant to Thorium Tetrachloride Melts

NASA Astrophysics Data System (ADS)

Akdeniz, Z.; Tosi, M. P.

2000-10-01

We study within an ionic model the structure and energetics of neutral and charged molecular clusters which may be relevant to molten ThCl4 and to its liquid mixtures with alkali chlorides, with reference to Raman scattering experiments by Photiadis and Papatheodorou. As stressed by these authors, the most striking facts for ThCl4 in comparison to other tetrachloride compounds (and in particular to ZrCl4) are the appreciable ionic conductivity of the pure melt and the continuous structural changes which occur in the melt mixtures with varying composition. After adjusting our model to data on the isolated ThCl4 tetrahedral molecule, we evaluate (i) the Th2Cl8 dimer and the singly charged species obtained from it by chlorine-ion transfer between two such neutral dimers; (ii) the ThCl6 and ThCl7 clusters both as charged anions and as alkali-compensated species; and (iii) various oligomers carrying positive or negative double charges. Our study shows that the characteristic structural properties of the ThCl4 compound and of the alkali-Th chloride systems are the consequence of the relatively high ionic character of the binding, which is already evident in the isolated ThCl4 monomer.

The beginning of the space age: information and mathematical aspect. To the 60th anniversary of the launch of the first sputnik

NASA Astrophysics Data System (ADS)

Sushkevich, T. A.

2017-11-01

60 years ago, on 4 October 1957, the USSR successfully launched into space the FIRST SPUTNIK (artificial Earth satellite). From this date begins the countdown of the space age. Information and mathematical software is an integral component of any space project. Discusses the history and future of space exploration and the role of mathematics and computers. For illustration, presents a large list of publications. It is important to pay attention to the role of mathematics and computer science in space projects and research, remote sensing problems, the evolution of the Earth's environment and climate, where the theory of radiation transfer plays a key role, and the achievements of Russian scientists at the dawn of the space age.

Ongoing Mars Missions: Extended Mission Plans

NASA Astrophysics Data System (ADS)

Zurek, Richard; Diniega, Serina; Crisp, Joy; Fraeman, Abigail; Golombek, Matt; Jakosky, Bruce; Plaut, Jeff; Senske, David A.; Tamppari, Leslie; Thompson, Thomas W.; Vasavada, Ashwin R.

2016-10-01

Many key scientific discoveries in planetary science have been made during extended missions. This is certainly true for the Mars missions both in orbit and on the planet's surface. Every two years, ongoing NASA planetary missions propose investigations for the next two years. This year, as part of the 2016 Planetary Sciences Division (PSD) Mission Senior Review, the Mars Odyssey (ODY) orbiter project submitted a proposal for its 7th extended mission, the Mars Exploration Rover (MER-B) Opportunity submitted for its 10th, the Mars Reconnaissance Orbiter (MRO) for its 4th, and the Mars Science Laboratory (MSL) Curiosity rover and the Mars Atmosphere and Volatile Evolution (MVN) orbiter for their 2nd extended missions, respectively. Continued US participation in the ongoing Mars Express Mission (MEX) was also proposed. These missions arrived at Mars in 2001, 2004, 2006, 2012, 2014, and 2003, respectively. Highlights of proposed activities include systematic observations of the surface and atmosphere in twilight (early morning and late evening), building on a 13-year record of global mapping (ODY); exploration of a crater rim gully and interior of Endeavour Crater, while continuing to test what can and cannot be seen from orbit (MER-B); refocused observations of ancient aqueous deposits and polar cap interiors, while adding a 6th Mars year of change detection in the atmosphere and the surface (MRO); exploration and sampling by a rover of mineralogically diverse strata of Mt. Sharp and of atmospheric methane in Gale Crater (MSL); and further characterization of atmospheric escape under different solar conditions (MVN). As proposed, these activities follow up on previous discoveries (e.g., recurring slope lineae, habitable environments), while expanding spatial and temporal coverage to guide new detailed observations. An independent review panel evaluated these proposals, met with project representatives in May, and made recommendations to NASA in June 2016. In this presentation, we will highlight the planned activities of these NASA Mars missions, as they start new chapters in their historic exploration of the dynamic and complex planet that is Mars.

Gamma-spectrometric measurement of radioactivity in agricultural soils of the Lombardia region, northern Italy.

PubMed

Guidotti, Laura; Carini, Franca; Rossi, Riccardo; Gatti, Marina; Cenci, Roberto M; Beone, Gian Maria

2015-04-01

This work is part of a wider monitoring project of the agricultural soils in Lombardia, which aims to build a database of topsoil properties and the potentially toxic elements, organic pollutants and gamma emitting radionuclides that the topsoils contain. A total of 156 agricultural soils were sampled according to the LUCAS (Land Use/Cover Area frame statistical Survey) standard procedure. The aim was to provide a baseline to document the conditions present at the time of sampling. The results of the project concerning soil radioactivity are presented here. The aim was to assess the content of (238)U, (232)Th, (137)Cs and (40)K by measuring soil samples by gamma spectrometry. (238)U, (232)Th and (40)K activities range 24-231, 20-70, and 242-1434 Bq kg(-1) respectively. The geographic distribution of (238)U reflects the geophysical framework of the Lombardia region: the soils with high content of uranium are distributed for the most part in the South Alpine belt, where the presence of magmatic rocks is widespread. These soils show an higher activity of (238)U than of (232)Th. The (238)U activities become lower than (232)Th when soils are located in the plain, originating from basic sedimentary rocks. (137)Cs activity ranges 0.4-86.8 kBq m(-2). The lowest activity of (137)Cs is in the plain, whereas the highest is in the North on soils kept as lawn or pasture. The (137)Cs activity of some samples suggests the presence of accumulation processes that lead to (137)Cs enriched soils. This is the first survey of gamma emitting radionuclides in Lombardia that is based on the LUCAS standard sampling. The results from this monitoring campaign are important for the human radiation exposure and provide the zero point, which will be useful for assessing future effects due to external factors such as human activities. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Color duplex assessment of 4th and 5th internal mammary artery perforators: the pedicles of the medially based lower pole breast flaps.

PubMed

Abdel-Monem, Kareem; Elshahat, Ahmed; Abou-Gamrah, Sherif; Eldin Abol-Atta, Hossam; Abd Eltawab, Reda; Massoud, Karim

2012-01-01

Reconstruction of a breast after mastectomy using the contralateral lower pole breast flap is an appealing procedure because it uses the tissues that were going to be excised during reduction of the sound breast to achieve symmetry. Literature mentioned that these flaps are supplied by the lower internal mammary artery perforators (IMAPs) with no further details. The aim of this study was to determine the site, size, and number of the 4th and 5th IMAPs by using preoperative color Duplex ultrasound and intraoperative exploration. Twenty breasts in 10 patients who presented for reduction mammoplasty were included in this study. Preoperative color duplex was used to determine IMAPs in the 4th and 5th intercostal spaces. These perforators were localized intraoperatively. Intravenous fluorescein injection was used to determine the perfusion of the lower pole breast flap on the basis of these perforators. Statistically, the 4th IMAPs diameters were significantly larger than the 5th IMAPs diameters (P < .05). The lower pole breast flap was perfused through these perforators. Color Duplex ultrasound is an accurate tool to preoperatively determine the 4th and 5th IMAPs.

Report to Congress on Sustainable Ranges, 2012

DTIC Science & Technology

2012-05-01

4ID AVN BDE HQ, 41st Fires BDE, 4th Sustainment BDE, 7-158 AVN (-), 6-52 AVN (-), 11th MP BN, 308th MI BDE, 21st Cavalry BDE (Air Combat), TF Odin, 1st...Army Division West HQ, 120 Infantry BDE, 166th AVN , 479 FA BDE, 407 AFSB, 901 SPT BN, 15th Sustainment BDE, 36th EN BDE, 89th MP BDE, 57th SIG BDE...1st Maneuver Enhancement Brigade; 162nd Infantry Training Brigade; the JRTC Operations Group; the 115th CSH and the 5th AVN BN. Home station unit

Systematic procedures to determine incentive/disincentive dollar amounts for highway transportation construction projects [research brief].

DOT National Transportation Integrated Search

2012-06-01

The Federal Highway Administration (FHWA) has encouraged state transportation agencies (STAs) to implement Incentive/Disincentive (I/D) contracting provisions for early project completion to minimize traffic disruption during highway construction. Th...

Public-private partnerships potential for Arizona-Mexico border infrastructure projects : executive summary.

DOT National Transportation Integrated Search

2009-09-01

This study of the PublicPrivate Partnership Potential for ArizonaMexico Border Infrastructure Projects originated as an action item of the Transportation, Infrastructure, and Ports Committee of the ArizonaMexico Commission. The purpose of th...

Multimodal needs, constraints, and opportunities : observations and lessons learned for Georgia and GDOT.

DOT National Transportation Integrated Search

2013-10-01

This research project assessed the multimodal transportation needs, constraints, and opportunities facing : the state of Georgia and the Georgia Department of Transportation (GDOT). The project report : includes: 1) a literature review focusing on th...

33 CFR 165.166 - Safety Zone: Macy's July 4th Fireworks, East River, NY.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Safety Zone: Macy's July 4th... § 165.166 Safety Zone: Macy's July 4th Fireworks, East River, NY. (a) Regulated area. The following area.... on July 4th. If the event is cancelled due to inclement weather then this section is in effect from 6...

33 CFR 165.166 - Safety Zone: Macy's July 4th Fireworks, East River, NY.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Safety Zone: Macy's July 4th... § 165.166 Safety Zone: Macy's July 4th Fireworks, East River, NY. (a) Regulated area. The following area.... on July 4th. If the event is cancelled due to inclement weather then this section is in effect from 6...

33 CFR 165.166 - Safety Zone: Macy's July 4th Fireworks, East River, NY.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Safety Zone: Macy's July 4th... § 165.166 Safety Zone: Macy's July 4th Fireworks, East River, NY. (a) Regulated area. The following area.... on July 4th. If the event is cancelled due to inclement weather then this section is in effect from 6...

33 CFR 165.166 - Safety Zone: Macy's July 4th Fireworks, East River, NY.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Safety Zone: Macy's July 4th... § 165.166 Safety Zone: Macy's July 4th Fireworks, East River, NY. (a) Regulated area. The following area.... on July 4th. If the event is cancelled due to inclement weather then this section is in effect from 6...

BIOMASS REBURNING - MODELING/ENGINEERING STUDIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vladimir Zamansky; Chris Lindsey; Vitali Lissianski

This project is designed to develop engineering and modeling tools for a family of NO{sub x} control technologies utilizing biomass as a reburning fuel. During the ninth reporting period (September 27--December 31, 1999), EER prepared a paper Kinetic Model of Biomass Reburning and submitted it for publication and presentation at the 28th Symposium (International) on Combustion, University of Edinburgh, Scotland, July 30--August 4, 2000. Antares Group Inc, under contract to Niagara Mohawk Power Corporation, evaluated the economic feasibility of biomass reburning options for Dunkirk Station. A preliminary report is included in this quarterly report.

Proceedings of the International Symposium on the Interaction of Non- Nuclear Munitions with Structures (4th), Held in Panama City Beach, Florida on 17-21 April 1989. Volume 2

DTIC Science & Technology

1989-04-01

1 AD-A257 318 Proceedings of the Fourth International Symposium on the Interaction of Non-nuclear Munfftons with Structures (volume 2) DTIC S ELECTE...volume 2) 6. AUTHOR( S ) Captain Diane B. Miller (Symposium Project Officer) 7. PERFORMING ORGANIZATION NAME( S ) ANI) ADDRESS(ES) 8. PEBF()WING...MONITORING AGENCY NAME( S ) AND ADDRESS(ES) - 10. SPONSORINGiMONITORING AGENCY REPORT NUMBER (Same as 7) 11, SUPPLEMENTARY NOTES 12a. DISTRIBUTION

Joint Project Manager (JPM) Chemical Biological Individual and Collective Protection Industry Day

DTIC Science & Technology

2008-07-22

ANSWER: The SBA operates the Office of Women’s B i O hi Th OWBO t thus ness wners p. e promo es e growth of women owned businesses through programs...TIC prioritization focused on a h i i k t f h tcompre ens ve r s managemen o w a we do not know: Absolute global production levels Absolute global...Modeling (For operational analyses) 2. Breakthrough Levels 3 D t ti A h. e ec on pproac es Multiple species may be present 4. Chemical Class Analysis

Special Course on Skin Friction Drag Reduction Held in Rhode-St-Genese, Belgium on 2-6 March 1992 (Reduction de Trainee de Frottement)

DTIC Science & Technology

1992-03-01

bodies such as tor- or by using these in combination with other control pedoes , are ideal targets for applying transition delay methods will also be...sponsored Tani and his colleagues to Nikuradse’s experimental project in Cambridge University, high speed video data for sand grain rough pipes, (see [125...lent kinetic energy balance in a LEBU modified don (1990) - also video presented at EDRM4 Lau- turbulent boundary layer. Proc. 11th Turbulence sanne

International Conference on Multiphoton Processes (4th) Held in Boulder, Colorado on July 13-17, 1987: Program and Abstracts.

DTIC Science & Technology

1988-07-01

depend on the duration of the pulse . The earlier results are nov extended to laser intensities of the order of 1012-10 13W/cm 2. The description of...projection operator formalism, described in (1) to analyze a state of a hydrogen atom in a very intense laser field. A starting Hamiltonian in dipole...system. The results of the microwave experiments are expected to scale to the case of excited multiply-charged hydrogenic ions in intense short- pulse

Loss of PTEN as a Predictive Biomarker of Response to Lithium Chloride, A Potential Targeted Treatment for Breast Cancer

DTIC Science & Technology

2013-11-01

COVERED (From - To) 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER...The grant was awarded on June 1st 2010. Dr. Higgins graduated from her Oncology Fellowship Program in Johns Hopkins Hospital on June 30th and... grant to support Dr. Higgins as she continued this work was submitted and processed in June 2010 in anticipation of this move. Johns Hopkins University

Evaluation of Lightweight, Relocatable Structures for Use in Theaters of Operations.

DTIC Science & Technology

1982-05-01

ADA117 02& CONSTRUCTION ENGINEERING RESEARCH LAB (ARMY) CHAMPAIGN IL F/6 13/2EVALUATION OF LI HThEISHT, RELOCATABLE STRUCTURES FOR USE IN TH-ETC(U...NUMBER(s) M. Frisch J. LambertM._ Ptak 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASK U.S. ARMY 4A 6 - T CONSTRUCTION ...System prefabricated buildings portable shelters 24L A2rRACT (C60901we S ,ewInd efb nOee -e and ldenif 7 by block numbe) The U.S. Army Construction

4th generation HIV screening in Massachusetts: a partnership between laboratory and program.

PubMed

Goodhue, Tammy; Kazianis, Arthur; Werner, Barbara G; Stiles, Tracy; Callis, Barry P; Dawn Fukuda, H; Cranston, Kevin

2013-12-01

The Massachusetts Department of Public Health's (MDPH) Office of HIV/AIDS (OHA) and Hinton State Laboratory Institute (HSLI) have offered HIV screening since 1985. Point-of-care screening and serum collection for laboratory-based testing is conducted at clinic and non-clinic-based sites across Massachusetts as part of an integrated communicable disease screening intervention. MDPH aimed to transition to a 4th generation HIV screening-based algorithm for testing all serum specimens collected at OHA-funded programs and submitted to the HSLI to detect acute HIV infections, detect and differentiate HIV-1 and HIV-2 infections, eliminate indeterminate results, reduce cost and turnaround time, and link newly diagnosed HIV+ individuals to care. The HSLI and OHA created a joint project management team to plan and lead the transition. The laboratory transitioned successfully to a 4th generation screening assay as part of a revised diagnostic algorithm. In the 12 months since implementation, a total of 7984 serum specimens were tested with 258 (3.2%) positive for HIV-1 and one positive for HIV-2. Eight were reported as acute HIV-1 infections. These individuals were linked to medical care and partner services in a timely manner. Turnaround time was reduced and the laboratory realized an overall cost savings of approximately 15%. The identification of eight acute HIV infections in the first year underscores the importance of using the most sensitive screening tests available. A multi-disciplinary program and laboratory team was critical to the success of the transition, and the lessons learned may be useful for other jurisdictions. Published by Elsevier B.V.

26 CFR 1.6073-3 - Short taxable years.

Code of Federal Regulations, 2010 CFR

2010-04-01

... before the 15th day of the 4th month of such taxable year if the requirements of section 6015(a) are met on or before the 1st day of the 4th month of such year. If such requirements are first met after the 1st day of the 4th month but before the 2d day of the 6th month, the declaration must be filed on or...

26 CFR 1.6073-3 - Short taxable years.

Code of Federal Regulations, 2014 CFR

2014-04-01

... on or before the 15th day of the 4th month of such taxable year if the requirements of section 6015(a) are met on or before the 1st day of the 4th month of such year. If such requirements are first met after the 1st day of the 4th month but before the 2d day of the 6th month, the declaration must be filed...

26 CFR 1.6073-3 - Short taxable years.

Code of Federal Regulations, 2011 CFR

2011-04-01

... on or before the 15th day of the 4th month of such taxable year if the requirements of section 6015(a) are met on or before the 1st day of the 4th month of such year. If such requirements are first met after the 1st day of the 4th month but before the 2d day of the 6th month, the declaration must be filed...

26 CFR 1.6073-3 - Short taxable years.

Code of Federal Regulations, 2012 CFR

2012-04-01

... on or before the 15th day of the 4th month of such taxable year if the requirements of section 6015(a) are met on or before the 1st day of the 4th month of such year. If such requirements are first met after the 1st day of the 4th month but before the 2d day of the 6th month, the declaration must be filed...

26 CFR 1.6073-3 - Short taxable years.

Code of Federal Regulations, 2013 CFR

2013-04-01

... on or before the 15th day of the 4th month of such taxable year if the requirements of section 6015(a) are met on or before the 1st day of the 4th month of such year. If such requirements are first met after the 1st day of the 4th month but before the 2d day of the 6th month, the declaration must be filed...

Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory T helper 2 cells

PubMed Central

Ogasawara, Takashi; Hatano, Masahiko; Satake, Hisae; Ikari, Jun; Taniguchi, Toshibumi; Tsuruoka, Nobuhide; Watanabe-Takano, Haruko; Fujimura, Lisa; Sakamoto, Akemi; Hirata, Hirokuni; Sugiyama, Kumiya; Fukushima, Yasutsugu; Nakae, Susumu; Matsumoto, Kenji; Saito, Hirohisa; Fukuda, Takeshi; Kurasawa, Kazuhiro; Tatsumi, Koichiro; Tokuhisa, Takeshi

2017-01-01

Mice deficient in the transcriptional repressor B-cell CLL/lymphoma 6 (Bcl6) exhibit similar T helper 2 (TH2) immune responses as patients with allergic diseases. However, the molecular mechanisms underlying Bcl6-directed regulation of TH2 cytokine genes remain unclear. We identified multiple Bcl6/STAT binding sites (BSs) in TH2 cytokine gene loci. We found that Bcl6 is modestly associated with the BSs, and it had no significant effect on cytokine production in newly differentiated TH2 cells. Contrarily, in memory TH2 (mTH2) cells derived from adaptively transferred TH2 effectors, Bcl6 outcompeted STAT5 for binding to TH2 cytokine gene loci, particularly Interleukin4 (Il4) loci, and attenuated GATA binding protein 3 (GATA3) binding to highly conserved intron enhancer regions in mTH2 cells. Bcl6 suppressed cytokine production epigenetically in mTH2 cells to negatively tune histone acetylation at TH2 cytokine gene loci, including Il4 loci. In addition, IL-33, a pro-TH2 cytokine, diminished Bcl6’s association with loci to which GATA3 recruitment was inversely augmented, resulting in altered IL-4, but not IL-5 and IL-13, production in mTH2 cells but no altered production in newly differentiated TH2 cells. Use of a murine asthma model that generates high levels of pro-TH2 cytokines, such as IL-33, suggested that the suppressive function of Bcl6 in mTH2 cells is abolished in severe asthma. These findings indicate a role of the interaction between TH2-promoting factors and Bcl6 in promoting appropriate IL-4 production in mTH2 cells and suggest that chronic allergic diseases involve the TH2-promoting factor-mediated functional breakdown of Bcl6, resulting in allergy exacerbation. PMID:28096407

[4th report of German Association of Cardiologists in private practice (BNK) on quality assurance in cardiac catheterization and coronary intervention 1999-2002].

PubMed

Levenson, Benny; Albrecht, Alexander; Göhring, Stefan; Haerer, Winfried; Herholz, Harald; Kaltenbach, Martin; Reifart, Nicolaus; Sauer, Gregor; Silber, Sigmund; Troger, Bernhard

2003-06-01

The Society of German Cardiologists in private practice (BNK) reports about its project on quality assurance in invasive cardiology (QuIK). Results of a computerized data collection and analysis of cardiac catheterizations and interventions in the years 1999-2002 are presented. These results are compared with other registries. The QuIK-project is done voluntarily by 70% of the society's cardiologists who perform invasive methods. A total of 225,562 diagnostic and 64,895 interventional procedures are documented over the 4 years. Patient characteristics and procedural data kept unchanged. Complication rates were low (< 2%), MACE < 0.5%. There was a rising number of patients referred with acute myocardial infarction. Less time was used to complete procedures from 1 year to another. Two out of three of the centers underwent a monitoring/auditing process in 2002. The desirable post-interventional follow-up after discharge in all cases appears to be impossible to fulfill under the given economical circumstances.

Mechanism of extractive/oxidative desulfurization using the ionic liquid inimidazole acetate: a computational study.

PubMed

Wang, Hanlu; Xu, Mingsheng; Zhou, Rujin

2017-02-01

The dual role of the ionic liquid 1-butyl-3-methyl-imidazolium trifluoroacetic acid ([C 4 mim]TFA) as an extractant for thiophene (TH) and a catalyst for the oxidation of TH was explored at the molecular level by performing density functional theory (DFT) calculations. The calculated interaction energies demonstrated why [C 4 mim]TFA is a better extractant for thiophene sulfone (THO 2 ) than for TH. Two pathways were proposed for the oxidation of TH to THO 2 with [C 4 mim]TFA acting as a catalyst. In the dominant pathway, a peracid is formed which then oxidizes TH to the sulfoxide and sulfones. The presence of [C 4 mim]TFA was found to greatly reduce the barrier to the oxidative desulfurization (ODS) of TH using H 2 O 2 as an oxidant. Graphical Abstract Possible reaction mechanisms of TH with the aid of [C4mim]TFAᅟ.

Application and Development of Appropriate Tools and Technologies for Cost-Effective Carbon Sequestration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bill Stanley; Patrick Gonzalez; Sandra Brown

2005-10-01

The Nature Conservancy is participating in a Cooperative Agreement with the Department of Energy (DOE) National Energy Technology Laboratory (NETL) to explore the compatibility of carbon sequestration in terrestrial ecosystems and the conservation of biodiversity. The title of the research project is ''Application and Development of Appropriate Tools and Technologies for Cost-Effective Carbon Sequestration''. The objectives of the project are to: (1) improve carbon offset estimates produced in both the planning and implementation phases of projects; (2) build valid and standardized approaches to estimate project carbon benefits at a reasonable cost; and (3) lay the groundwork for implementing cost-effective projects,more » providing new testing ground for biodiversity protection and restoration projects that store additional atmospheric carbon. This Technical Progress Report discusses preliminary results of the six specific tasks that The Nature Conservancy is undertaking to answer research needs while facilitating the development of real projects with measurable greenhouse gas reductions. The research described in this report occurred between April 1st , 2005 and June 30th, 2005. The specific tasks discussed include: Task 1: carbon inventory advancements; Task 2: emerging technologies for remote sensing of terrestrial carbon; Task 3: baseline method development; Task 4: third-party technical advisory panel meetings; Task 5: new project feasibility studies; and Task 6: development of new project software screening tool.« less

Application and Development of Appropriate Tools and Technologies for Cost-Effective Carbon Sequestration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bill Stanley; Patrick Gonzalez; Sandra Brown

2006-01-01

The Nature Conservancy is participating in a Cooperative Agreement with the Department of Energy (DOE) National Energy Technology Laboratory (NETL) to explore the compatibility of carbon sequestration in terrestrial ecosystems and the conservation of biodiversity. The title of the research project is ''Application and Development of Appropriate Tools and Technologies for Cost-Effective Carbon Sequestration''. The objectives of the project are to: (1) improve carbon offset estimates produced in both the planning and implementation phases of projects; (2) build valid and standardized approaches to estimate project carbon benefits at a reasonable cost; and (3) lay the groundwork for implementing cost-effective projects,more » providing new testing ground for biodiversity protection and restoration projects that store additional atmospheric carbon. This Technical Progress Report discusses preliminary results of the six specific tasks that The Nature Conservancy is undertaking to answer research needs while facilitating the development of real projects with measurable greenhouse gas reductions. The research described in this report occurred between April 1st , 2005 and June 30th, 2005. The specific tasks discussed include: Task 1: carbon inventory advancements; Task 2: emerging technologies for remote sensing of terrestrial carbon; Task 3: baseline method development; Task 4: third-party technical advisory panel meetings; Task 5: new project feasibility studies; and Task 6: development of new project software screening tool.« less

Management of Bottom Sediments Containing Toxic Substances. Proceedings of the U.S./Japan Experts Meeting (8th) Held at Tokyo, Japan on 8-10 November 1982

DTIC Science & Technology

1984-07-01

curtain has a peripheral length of 300 m). The spraying is done by a pump and 32 I 0 0. 00 0 -O4 No..14 NO.3 0 𔃺O 7 No.2N 14o.9 of Disrio No.4 0 04 0...Erosion Board, Washington, D.C., May 1950. HALL, J.V. and WATTS, G.M.,, Beach Rehabilitation by Fill and Nourishment. TYazactionz o6 the AmeAican...Demonstration Project 9J a statistically significant 1ioaccumulation of PCB. The capping exercise was based upon two premises: (1) that the capped mound would

Different modulation by histamine of IL-4 and interferon-gamma (IFN-γ) release according to the phenotype of human Th0, Th1 and Th2 clones

PubMed Central

LAGIER, B; LEBEL, B; BOUSQUET, J; PÈNE, J

1997-01-01

Histamine, an important inflammatory mediator in allergic diseases and asthma, has been reported to have modulator effects on T cells, suggesting that the bronchial microenvironment may regulate the function of resident T cells. We examined the effect of histamine on the release of the Th2-associated cytokines IL-4 and IL-5 and the Th1-associated cytokine IFN-γ by 30 CD4+ T cell clones from peripheral blood or bronchial biopsy of one atopic subject. Based on the IL-4/IFN-γ ratio, the clones were ascribed to the Th2 (ratio >1), Th0 (ratio ⩾ 0.1 and ⩽1) or Th1 (ratio <0.1) phenotype. Histamine inhibited IFN-γ production by Th1-like cells (P<0.02, Kruskall–Wallis), especially from bronchial biopsy, but had no effect on IL-4 release. Regarding Th0 clones, histamine inhibited IL-4 production (P<0.02) in a dose-dependent manner and slightly inhibited IFN-γ production, but had no effect on Th2-like cells. Histamine had a heterogeneous and insignificant effect on IL-5 production. The H2-receptor antagonist ranitidine completely reversed the inhibition of IL-4 and IFN-γ production, whereas the agonist dimaprit mimicked this effect. In contrast, H1- and H3-receptor agonists and antagonists had no significant effect. These data demonstrate that histamine has different effects on IL-4 and IFN-γ release by T helper cells according to their phenotype via H2-receptors. This study extends the immunomodulatory effects of histamine which may contribute to the perpetuation of airway inflammation in asthma. PMID:9182905

Human impacts on 20th century fire dynamics and implications for global carbon and water trajectories

NASA Astrophysics Data System (ADS)

Li, F.; Lawrence, D. M.; Bond-Lamberty, B. P.

2017-12-01

Fire is a fundamental Earth system process and the primary ecosystem disturbance on the global scale. It affects carbon and water cycles through its impact on terrestrial ecosystems, and at the same time, is regulated by weather and climate, vegetation characteristics, and, importantly, human ignition and efforts to suppress fires (i.e., the direct human effect on fire). Here, we utilize the Community Land Model version 4.5 (CLM4.5) to generate a quantitative understanding of the impacts on fire dynamics and associated carbon and water cycling that can be attributed to changes in human ignition and suppression over the 20th century. We find that the net impact of increases in human ignition and suppression significantly reduce the 20th century averaged global burned area by 38 Mha/yr. The reduction increases since 1920, rising to 103 Mha/yr less burned area at the end of the century. Land carbon gain is weakened by 17% over the 20th century, mainly due to increased human deforestation fires and associated escape fires (i.e., degradation fires) in the tropical humid forests, even though the decrease in burned area in many other regions due to human fire suppression acts to increase land carbon gain. The direct human effect on fire also weakens the 20th century upward trend of global runoff by 6%, and enhances the upward trend in global evaportranspiration since 1945 by 7%. In addition, the above impacts in densely populated, highly developed (if population density > 0.1 person/km2), or moderately populated and developed regions are of opposite sign to those in other regions. Our study suggests that particular attention should be paid to human deforestation and degradation fires in the tropical humid forests when reconstructing and projecting fire carbon emissions and net atmosphere-land carbon exchange and estimating resultant impacts of direct human effect on fire.

Impact of North America on the aerosol composition in the North Atlantic free troposphere

NASA Astrophysics Data System (ADS)

García, M. Isabel; Rodríguez, Sergio; Alastuey, Andrés

2017-06-01

In the AEROATLAN project we study the composition of aerosols collected over ˜ 5 years at Izaña Observatory (located at ˜ 2400 m a.s.l. in Tenerife, the Canary Islands) under the prevailing westerly airflows typical of the North Atlantic free troposphere at subtropical latitudes and midlatitudes. Mass concentrations of sub-10 µm aerosols (PM10) carried by westerly winds to Izaña, after transatlantic transport, are typically within the range 1.2 and 4.2 µg m-3 (20th and 80th percentiles). The main contributors to background levels of aerosols (PM10 within the 1st-50th percentiles = 0.15-2.54 µg m-3) are North American dust (53 %), non-sea-salt sulfate (14 %) and organic matter (18 %). High PM10 events (75th-95th percentiles ≈ 4.0-9.0 µg m-3) are prompted by dust (56 %), organic matter (24 %) and non-sea-salt sulfate (9 %). These aerosol components experience a seasonal evolution explained by (i) their spatial distribution in North America and (ii) the seasonal shift of the North American outflow, which migrates from low latitudes in winter (˜ 32° N, January-March) to high latitudes in summer (˜ 52° N, August-September). The westerlies carry maximum loads of non-sea-salt sulfate, ammonium and organic matter in spring (March-May), of North American dust from midwinter to mid-spring (February-May) and of elemental carbon in summer (August-September). Our results suggest that a significant fraction of organic aerosols may be linked to sources other than combustion (e.g. biogenic); further studies are necessary for this topic. The present study suggests that long-term evolution of the aerosol composition in the North Atlantic free troposphere will be influenced by air quality policies and the use of soils (potential dust emitter) in North America.

Reproduction of 20th century inter- to multi-decadel surface temperature variablilty in radiatively forced coupled climate models

USDA-ARS?s Scientific Manuscript database

Coupled Model Intercomparison Project 3 simulations of surface temperature were evaluated over the period 1902-1999 to assess their ability to reproduce historical temperature variability at 211 global locations. Model performance was evaluated using the running Mann Whitney-Z method, a technique th...

Maximum speed limits. Volume 3, A programmed implementation manual for setting a speed limit based on the 85th percentile

DOT National Transportation Integrated Search

1970-10-01

This report contains the implementation manual developed as a part of the project "Maximum Speed Limits." The manual consists of a programed educational unit and a field workguide concerning the setting of speed limits based on the 85th percentile sp...

Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (PME) (24th, Hiroshima, Japan, July 23-27, 2000), Volume 1.

ERIC Educational Resources Information Center

Nakahara, Tadao, Ed.; Koyama, Masataka, Ed.

The first volume of the 24th annual conference of the International Group for the Psychology of Mathematics Education includes plenary addresses, plenary panel discussions, research forum, project groups, discussion groups, short oral communications, and poster presentations. (ASK)

Applying ecological insights to increase productivity in tropical plantations

Treesearch

Dan Binkley; Jean-Paul Laclau; Jose Luiz Stape; Michael G. Ryan

2010-01-01

In the 19th and 20th Centuries, forest productivity was examined largely as a retrospective exercise: growth of forests was tracked over time, and these historical trends were projected empirically into the future (Puettmann et al., 2008). Silviculturists explained growth of trees and stands in terms of unquantifiable "growing space,"...

The Lawyers in the 16th-18th Century's Germany: A Historical Database.

ERIC Educational Resources Information Center

Ranieri, Filippo

1990-01-01

Investigates the sociological backgrounds of German lawyers of the Holy Roman Empire through an analysis of the dissertations and disputations written during the seventeenth and eighteenth centuries. Focuses on their university education, family circumstances, and careers. Creates an information data bank to carry out the project. Predicts further…

Frontiers in neurodegeneration--new insights and prospects--20th HUPO BPP Workshop: 15 September 2013, Yokohama, Japan.

PubMed

Schrötter, Andreas; El Magraoui, Fouzi; Gröttrup, Bernd; Heinsen, Helmut; Marcus, Katrin; Meyer, Helmut E; Park, Young Mok; Grinberg, Lea T

2014-06-01

The HUPO Brain Proteome Project (HUPO BPP) held its 20th workshop in Yokohama, Japan, September 15, 2013. The focus of the autumn workshop was on new insights and prospects of neurodegenerative diseases. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Reader Response Makes History.

ERIC Educational Resources Information Center

Shafer, Gregory

1997-01-01

Describes an interdisciplinary unit that brought the Civil War to life for 11th-grade students in a team-taught unit that highlighted student-driven response to reading. Describes use of a 19th-century essay supporting slavery, Upton Sinclair's "The Jungle,""Huckleberry Finn," Civil War poetry and other writings, and student projects based on the…

NREL Offers Renewable Energy Award at International Competition

Science.gov Websites

Research Institute will offer a special renewable energy award May 14 at the International Science and Offers Renewable Energy Award at International Competition For more information contact: e:mail of science fairs. As the only international science project competition for 9th - 12th graders, ISEF

Project Probase: Engaging Technology for 11th and 12th Grade Students

ERIC Educational Resources Information Center

Wyse-Fisher, Dustin J.; Daugherty, Michael K.; Satchwell, Richard E.; Custer, Rodney L.

2005-01-01

Journal manuscripts and national reports published during the last 20 years (Bensen, 1993; DeVries, 1996; AAAS, 1989; National Academy of Engineering, 2002; ITEA, 1996; Zuga, 1989) presented a defensible rationale for the technology education profession and focused on the delivery of technological literacy for the nation's youth. This call for…

Proceedings of the International Academy for Information Management Annual Conference (12th, Atlanta, Georgia, December 12-14, 1997).

ERIC Educational Resources Information Center

Rogers, Camille, Ed.

This proceedings includes 62 papers presented at the 12th annual International Academy for Information Management (IAIM) conference. Topics of papers include: electronic undergraduate courses; software for teaching change management; cooperative projects; experiential learning; World Wide Web applications; internationalization of the information…

Comparing Science Learning among 4th-, 5th-, and 6th-Grade Students: STS versus Textbook-Based Instruction

ERIC Educational Resources Information Center

Yager, Robert E.; Choi, AeRan; Yager, Stuart O.; Akcay, Hakan

2009-01-01

Fifteen 4th-, 5th-, and 6th-grade teachers from five school districts each taught two sections of science--one with a Science-Technology-Society (STS) approach and the other with a more traditional textbook approach in which basic science concepts were the major organizers. Local, current, and personally relevant issues provided the context and…

75 FR 38718 - Safety Zone; Sault Sainte Marie 4th of July Fireworks, St. Mary's River, Sault Sainte Marie, MI

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-06

...-AA00 Safety Zone; Sault Sainte Marie 4th of July Fireworks, St. Mary's River, Sault Sainte Marie, MI... restrict vessels from a portion of the St. Mary's River during the Sault Sainte Marie 4th of July Fireworks... the setup and launching of fireworks in conjunction with the Sault Sainte Marie 4th of July Fireworks...

Evidence-based Modeling of Critical Illness: An Initial Consensus from the Society for Complexity in Acute Illness

PubMed Central

Vodovotz, Yoram; Clermont, Gilles; Hunt, C. Anthony; Lefering, Rolf; Bartels, John; Seydel, Ruediger; Hotchkiss, John; Ta'asan, Shlomo; Neugebauer, Edmund; An, Gary

2007-01-01

Introduction: Given the complexity of biological systems, understanding their dynamic behaviors, such as the Acute Inflammatory Response (AIR), requires a formal synthetic process. Dynamic Mathematical Modeling (DMM) represents a suite of methods intended for inclusion within the required synthetic framework. DMM, however, is a relatively novel approach in the practice of biomedical research. The Society for Complexity in Acute Illness (SCAI) was formed in 2004 from the leading research groups utilizing DMM in the study of acute inflammation. This Society believes that it is important to offer guidelines for the design, development and utilization of DMM in the setting of AIR research to avoid the “garbage-in garbage-out” problem. Accordingly, SCAI identified a need for and carried out a critical appraisal of DMM as currently used in the setting of acute illness. Methods: The SCAI annual meeting in 2005, the 4th International Conference on Complexity in Acute Illness (ICCAI; Cologne, Germany), was structured with the intent of developing a consensus statement on the methods and execution of DMM in AIR research. The conference was organized to include a series of interactive breakout sessions that included thought leaders from both the DMM and acute illness fields, the results of which were then presented in summary form to the entire group for discussion and consensus. The information in this manuscript represents the concatenation of those presentations. Results: The output from the 4th ICCAI involved consensus statements for the following topics: 1) the need for DMM, 2) a suggested approach for the process of establishing a modeling project, 3) the type of “wet” lab experiments and data needed to establish a modeling project, 4) general quality measures for data to be input to a modeling project, and 5) a descriptive list of several types of DMM to provide guidance in selection of a method for a project. Conclusion: We believe that the complexity of biological systems requires that DMM needs to be among the methods used to improve understanding and make progress with attempts to characterize and manipulate the AIR. We believe that this consensus statement will help guide the integration, rational implementation, and standardization of DMM into general biomedical research. PMID:17371750

Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster.

PubMed

Johansson, Anna-Mia; Stenberg, Per; Bernhardsson, Carolina; Larsson, Jan

2007-05-02

Drosophila melanogaster exhibits two expression-regulating systems that target whole, specific chromosomes: the dosage compensation system whereby the male-specific lethal complex doubles transcription of genes on the male X-chromosome and the chromosome 4-specific protein Painting of fourth, POF. POF is the first example of an autosome-specific protein and its presence raises the question of the universality of chromosome-specific regulation. Here we show that POF and heterochromatin protein 1 (HP1) are involved in the global regulation of the 4th chromosome. Contrary to previous conclusions, Pof is not essential for survival of diplo-4th karyotype flies. However, Pof is essential for survival of haplo-4th individuals and expression of chromosome 4 genes in diplo-4th individuals is decreased in the absence of Pof. Mapping of POF using chromatin immunoprecipitation suggested that it binds within genes. Furthermore, we show that POF binding is dependent on heterochromatin and that POF and HP1 bind interdependently to the 4th chromosome. We propose a balancing mechanism involving POF and HP1 that provides a feedback system for fine-tuning expression status of genes on the 4th chromosome.

Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster

PubMed Central

Johansson, Anna-Mia; Stenberg, Per; Bernhardsson, Carolina; Larsson, Jan

2007-01-01

Drosophila melanogaster exhibits two expression-regulating systems that target whole, specific chromosomes: the dosage compensation system whereby the male-specific lethal complex doubles transcription of genes on the male X-chromosome and the chromosome 4-specific protein Painting of fourth, POF. POF is the first example of an autosome-specific protein and its presence raises the question of the universality of chromosome-specific regulation. Here we show that POF and heterochromatin protein 1 (HP1) are involved in the global regulation of the 4th chromosome. Contrary to previous conclusions, Pof is not essential for survival of diplo-4th karyotype flies. However, Pof is essential for survival of haplo-4th individuals and expression of chromosome 4 genes in diplo-4th individuals is decreased in the absence of Pof. Mapping of POF using chromatin immunoprecipitation suggested that it binds within genes. Furthermore, we show that POF binding is dependent on heterochromatin and that POF and HP1 bind interdependently to the 4th chromosome. We propose a balancing mechanism involving POF and HP1 that provides a feedback system for fine-tuning expression status of genes on the 4th chromosome. PMID:17318176

Meal pattern among Norwegian primary-school children and longitudinal associations between meal skipping and weight status.

PubMed

Stea, Tonje H; Vik, Frøydis N; Bere, Elling; Svendsen, Martin V; Oellingrath, Inger M

2015-02-01

To investigate meal pattern longitudinally and explore whether meal skipping was associated with overweight among Norwegian children and adolescents. Longitudinal study. Children's meal frequencies were reported by their parents using a retrospective FFQ. Weight and height were measured by public health nurses. Descriptive data comparing 4th and 7th grade were analysed by paired-sample t tests for continuous variables and χ 2 tests for categorical variables. Odds ratio estimates, including confidence intervals, with BMI category (normal/overweight) as the dependent variable, were determined through logistic regression analyses. Primary schools, Telemark County, Norway. A cohort of 428 Norwegian boys and girls; 4th graders in 2007, 7th graders in 2010. The number of children eating four main meals per day (regular meal frequency) decreased from 4th grade (47 %) to 7th grade (38 %; P = 0·001). Those who ate regular meals in 4th grade but not in 7th grade had higher odds (OR = 3·1; 95 % CI 1·1, 9·0) of being overweight in 7th grade after adjusting for gender, maternal education and physical activity, but the odds ratio was not statistically significant after adjusting for overweight in 4th grade (OR = 2·8; 95 % CI 0·7, 11·6). The present study showed significant increases in overall meal skipping among children between 4th and 7th grade. The results indicate an association between overweight and meal skipping, but additional prospective and longitudinal analyses and intervention trials are warranted to confirm this relationship.

UCAC1: New Proper Motions for 27 Million Stars on the Southern Hemisphere

NASA Astrophysics Data System (ADS)

Zacharias, N.; Monet, S. Urban D. G.; Platais, I.; Wycoff, G. L.; Zacharias, M. I.; Rafferty, T. J.

The big impact of UCAC on galactic kinematics and dynamics studies will be outlined. The USNO CCD Astrograph (UCA) started an astrometric sky survey in February 1998 at Cerro Tololo, Chile. By January 2000 about 90% of the Southern Hemisphere has been observed and full sky coverage is expected by early 2003. In addition, calibration fields around extragalactic reference frame sources and selected open clusters are observed frequently. The UCAC project is a huge dedicated astrometric survey similar to the AGK2 and AGK3 projects but vastly exceeding those with respect to higher accuracy, limiting magnitude (16th) and full sky coverage. A first catalog (UCAC1) is being published in early 2000 for 27 million stars. Stars in the range of 9 to 14th magnitude have a positional precision of 20 mas. The UCAC1 will utilize positions from the USNO A2.0 catalog for determining proper motions, which are expected to be about 8 mas/yr for this initial release. Higher precision proper motions, expected to be in the 3 to 4 mas/yr range, will be derived utilizing a variety of early epoch data, including re-measuring of the Southern Proper Motion (SPM) survey first epoch plates.

Poly-Si TFTs integrated gate driver circuit with charge-sharing structure

NASA Astrophysics Data System (ADS)

Chen, Meng; Lei, Jiefeng; Huang, Shengxiang; Liao, Congwei; Deng, Lianwen

2017-06-01

A p-type low-temperature poly-Si thin film transistors (LTPS TFTs) integrated gate driver using 2 non-overlapped clocks is proposed. This gate driver features charge-sharing structure to turn off buffer TFT and suppresses voltage feed-through effects. It is analyzed that the conventional gate driver suffers from waveform distortions due to voltage uncertainty of internal nodes for the initial period. The proposed charge-sharing structure also helps to suppress the unexpected pulses during the initialization phases. The proposed gate driver shows a simple circuit, as only 6 TFTs and 1 capacitor are used for single-stage, and the buffer TFT is used for both pulling-down and pulling-up of output electrode. Feasibility of the proposed gate driver is proven through detailed analyses. Investigations show that voltage bootrapping can be maintained once the bootrapping capacitance is larger than 0.8 pF, and pulse of gate driver outputs can be reduced to 5 μs. The proposed gate driver can still function properly with positive {V}{TH} shift within 0.4 V and negative {V}{TH} shift within -1.2 V and it is robust and promising for high-resolution display. Project supported by the Science and Technology Project of Hunan Province, China (No. 2015JC3401)

Cosmic Cinematography With the LSSTO

NASA Astrophysics Data System (ADS)

Liu, C. T.; Borne, K.; Stubbs, C.; Tyson, J. A.; LSSTO Collaboration

2001-12-01

The Large-Area Synoptic Survey Telescope Observatory (LSSTO; http://lssto.org) will be an 8.4-meter, 7 square-degree field telescope and camera, and will represent an increase in astronomical survey power more than 20-fold over any observatory now operating or under construction. Each night, LSSTO will image over 1400 square degrees of sky, to a depth of at least 24th magnitude, and make the data publicly available the next day. A co-added deep color image of 14,000 square degrees of the sky to 27th magnitude will also be available. The LSSTO database will be on spinning disks at various sites around the world. At 0.2 arcseconds per pixel, these data will represent unprecedented deep sky images which will follow celestial changes in time. We show some of the plans to broaden the scope of the LSSTO project to include small colleges, amateur astronomers, K-12 and general public astronomy consumers. These include [1] High definition video walls with data feeds of 1000 GB/sec; [2] 3-D virtual reality displays using both personal computers and massive projection systems such as the Hayden Planetarium Digital Dome; and [3] interactive data analysis and viewing in the time dimension, producing a true ``movie of the cosmos."

Synthesis and characterization of thorium(IV) sulfates.

PubMed

Knope, Karah E; Wilson, Richard E; Skanthakumar, S; Soderholm, L

2011-09-05

Three Th(IV) sulfates, two new and one previously reported, have been synthesized from aqueous solution. In all of the compounds, the sulfate anions coordinate the Th(4+) metal center(s) in a monodentate manner with Th-S distances of 3.7-3.8 Å. Th(SO(4))(2)(H(2)O)(7)·2(H(2)O) (1; P2(1)/m, a = 7.224(1) Å, b = 12.151(1) Å, c = 7.989(1) Å, ss =98.289(2)°) and Th(4)(SO(4))(7)(H(2)O)(7)(OH)(2)·H(2)O (2; Pnma, a = 18.139(2) Å, b = 11.173(1) Å, c = 14.391(2) Å) each contain 9-coordinate monomeric (1,2) and dimeric (2) Th(IV) cations in monocapped square antiprism geometry. Alternatively, Th(OH)(2)SO(4) (3; Pnma, a = 11.684(1) Å, b = 6.047(1) Å, c = 7.047(1) Å) is built from chains of hydroxo-bridged, 8-coordinate Th(4+) centers. Whereas 1 adopts a molecular structure, 2 and 3 both exhibit 3D architectures. Differences in the dimensionality and the topology of 1-3 are manifested in the local coordination environment about the Th(IV) centers, the formation of oligomeric Th(4+) species, and the extended connectivity of the sulfate ligands. Herein, we report the syntheses and characterization of 1-3 as well as the atomic correlations of 1 in solution, as determined by high-energy X-ray scattering (HEXS).

75 FR 14207 - Virginia Electric and Power Company d/b/a/Dominion Virginia Power, and Old Dominion Electric...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-24

..., VA. For Further Information, Contact: Alicia Williamson, Project Manager, Environmental Projects...-mail to Alicia[email protected] . Dated at Rockville, Maryland, this 17th day of March 2010. For the...

Washington State Ferries (WSF) Wireless Connection Project (WCP) evaluation

DOT National Transportation Integrated Search

2005-05-31

The purpose of the Washington State Ferries (WSF) Wireless Connection Project (WCP) was to provide passengers of the WSF system continuous high speed internet access at the dock and onboard ferries while en route to enhance the user experience. Th...

Transit safety retrofit package development : final report.

DOT National Transportation Integrated Search

2014-07-01

This report provides a summary of the Transit Safety Retrofit Package (TRP) Development project and its results. The report documents results of each project phase, and provides recommended next steps as well as a vision for a next generation TRP. Th...

Knocking at the College Door: Projections of High School Graduates, 9th Edition. Revised

ERIC Educational Resources Information Center

Bransberger, Peace; Michelau, Demarée K.

2017-01-01

For nearly 40 years, the Western Interstate Commission for Higher Education (WICHE) has produced projections of high school graduates. The purpose of "Knocking at the College Door: Projections of High School Graduates" is to equip decision-makers at all levels with information about how the numbers of high school graduates are likely to…

Mobilizing and Managing Social Capital: On Roles and Responsibilities of Local Facilitators in Territorial Development

ERIC Educational Resources Information Center

Schermer, Markus; Kirchengast, Christoph; Petit, Sandrine; Magnani, Natalia; Mieville-Ott, Valerie

2010-01-01

The paper explores the difficulties and challenges in mobilizing and managing social capital in concrete local and territorial directed rural development project activities. The main focus is put on the roles of local facilitators working with farmers and other local stakeholders during project implementation. The EU 5th framework project IMALP…

Career Advancement through Bilingual Education Skills. Project CABES, 1987-1988.

ERIC Educational Resources Information Center

Berney, Tomi D.; Velazquez, Clara

This report evaluates Project CABES (Career Advancement through Bilingual Education Skills) during its second year of extension of a federal funding cycle at New York's Seward Park High School. The major goal of Project CABES was to provide career advancement skills to 250 Hispanic 9th- through 12-grade students of limited English proficiency…

Learning Physics through Project-Based Learning Game Techniques

ERIC Educational Resources Information Center

Baran, Medine; Maskan, Abdulkadir; Yasar, Seyma

2018-01-01

The aim of the present study, in which Project and game techniques are used together, is to examine the impact of project-based learning games on students' physics achievement. Participants of the study consist of 34 9th grade students (N = 34). The data were collected using achievement tests and a questionnaire. Throughout the applications, the…

40. From Final Construction Report on the Haleakala Road ProjectNR7, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

40. From Final Construction Report on the Haleakala Road Project--NR-7, Hawaii National Park, Island of Maui, Territory of Hawaii, T.H. GENERAL VIEW OT THE PROJECT SHOWING CONSPICUOUS SCARS. THE BEFORE PHOTO OF A BEFORE AND AFTER SET. AFTER PHOTO IS HI-52-41. - Haleakala National Park Roads, Pukalani, Maui County, HI

Project-Based Social Justice Mathematics: A Case Study of Five 6th Grade Students

ERIC Educational Resources Information Center

McHugh, Maighread L.

2015-01-01

The purpose of this qualitative multiple case study was to explore how five sixth grade female students navigated the process of project-based learning as they designed and implemented their own project centered on mathematics while using a social justice lens. The theoretical frameworks of Authentic Intellectual Work and Social Justice…

Effects of Streptococcus thermophilus TH-4 in a rat model of doxorubicin-induced mucositis.

PubMed

Wang, Hanru; Brook, Caitlin L; Whittaker, Alexandra L; Lawrence, Andrew; Yazbeck, Roger; Howarth, Gordon S

2013-08-01

Mucositis is a debilitating intestinal side effect of chemotherapeutic regimens. Probiotics have been considered a possible preventative treatment for mucositis. Streptococcus thermophilus TH-4 (TH-4), a newly identified probiotic, has been shown to partially alleviate mucositis induced by administration of the antimetabolite chemotherapy drug, methotrexate in rats; likely mediated through a mechanism of folate production. However, its effects against other classes of chemotherapy drug have yet to be determined. The authors investigated the effects of TH-4 in a rat model of mucositis induced by the anthracycline chemotherapy drug, doxorubicin. Gastrointestinal damage was induced in female Dark Agouti rats (148.3 ± 1.5 g) by intraperitoneal injection of doxorubicin (20 mg/kg). Animals recieved a daily oral gavage of TH-4 at 10(9) cfu/ml or skim milk (vehicle) from days 0 to 8. At day 6, rats were injected with either saline or doxorubicin. At kill, small intestinal tissues were collected for determination of sucrase and myeloperoxidase (MPO) activities and histological assessment. Body weight was significantly decreased by doxorubicin compared with normal controls (p < 0.05). Histological parameters, such as crypt depth and villus height, were also significantly decreased by doxorubicin. TH-4 partially prevented the loss of body weight induced by doxorubicin (2.3% compared with 4%), but provided no further therapeutic benefit. The minimal amelioration of doxorubicin-induced mucositis by TH-4 further supports folate production as a likely mechanism of TH-4 action against methotrexate-induced mucositis. Further studies into TH-4 are required to confirm its applicability to other conventional chemotherapy regimens.

Malaysia's Experience in the Monitoring of Investment and Results of Water Resources Management

NASA Astrophysics Data System (ADS)

Zakaria, Salmah Binti; Lee, Jin

2010-05-01

The current status of IWRM implementation in Malaysia, overview of development planning process and financial allocations together with monitoring of IWRM in Malaysia are first presented. This is followed by a case study review of Malaysia's 9th 5-year Development Plan (2005-2010) so as to provide a deeper understanding and appreciation of the current approach adopted by the Malaysian government in the formulation of development policies, project planning, budget allocation and o monitoring of projects. Arising from the review it was highlighted that the water-related, sectoral developmental objectives are found in all the 5 developmental thrusts in the 9th Malaysia Plan. This is because water is an essential natural resource and is also an economic good. Thus, it was concluded that in order for the monitoring of investments in IWRM and results to be effective and useful to support policy formulation to achieve the goal of IWRM there is a need for a collation of all information reported under the different, water-related, sectoral developmental objectives in the 9th Malaysia Plan to be organised within an IWRM framework. It was also concluded that a major IWRM challenge for Malaysia is how to make the transition from the current, narrow, sector-specific, financial and budgeting paradigm of the sectorial agencies to the “total cost” paradigm that involves taking into consideration and integrating the costs in other sectors affected by any projects proposed within a sector. The current, sectorial-focus approach, adopted in the 9th Malaysia Plan, logically measures the effectiveness of sectorial agencies by their ability to achieve their immediate sectorial goals and targets, most often with emphasis on infrastructure projects since the impacts of such projects are usually immediate and visible. However, the use of such approach alone, without taking into account the costs that are borne by other interfacing sectors, and also within the sector over the long term, is unsustainable.

A COMPREHENSIVE PROGRAM IN ENGLISH FOR THE 7TH, 8TH AND 9TH GRADE --LITERATURE, LANGUAGE, COMPOSITION, FOR HONORS STUDENTS AND AVERAGE STUDENTS. PART 2, CONSTRUCTING ACHIEVEMENT TESTS DURING A SUMMER WORKSHOP FOR PARTIAL EVALUATION OF A PROJECT ENGLISH DEMON. CTR.

ERIC Educational Resources Information Center

HILLOCKS, GEORGE, JR.; KEARNEY, PATRICIA A.

THIS FINAL REPORT OF THE EUCLID ENGLISH DEMONSTRATION CENTER DESCRIBES THE CREATION OF A JUNIOR HIGH SCHOOL ENGLISH PROGRAM IN LITERATURE, LANGUAGE, AND COMPOSITION. PART 1 OF THE REPORT DISCUSSES (1) THE PRODUCTION AND DEMONSTRATION OF 31 THEMATICALLY-DEVELOPED TEACHING UNITS, (2) A SERIES OF SHORT, CONCEPT-CENTERED CONFERENCES TO EDUCATE…

Project VALOR: Trajectories of Change in PTSD in Combat Exposed Veterans

DTIC Science & Technology

2016-10-01

comparison of DSM-5 and ICD-11. Poster to be presented at the Association for Behavioral and Cognitive Therapy 50th Annual Meeting. New York, NY. Black, S...Behavioral and Cognitive Therapies 49th Annual Meeting. Chicago, IL. Black, S. K., Erb, S. Bovin, M. J., Green, J., Marx, B. P., Rosen, R. C., & Keane, T...for Behavioral and Cognitive Therapies 49th Annual Meeting. Chicago, IL. Erb, S., Kearns, J., Bovin, M. J., Black, S., Annunziata, A., & Marx, B. P

33 CFR 165.171 - Safety Zones for fireworks displays held in Coast Guard Sector Northern New England Captain of...

Code of Federal Regulations, 2011 CFR

2011-07-01

....3Bangor 4th of July Fireworks • Event Type: Fireworks Display. • Sponsor: Bangor 4th of July Fireworks. • Date: July 4th, as specified in the USCG District 1 Local Notice to Mariners. • Time: 8:00 pm to 10:30...° 47′27″ N, 068° 46′31″ W (NAD 83). 7.4Bar Harbor 4th of July Fireworks • Event Type: Fireworks Display...

State Test Score Trends through 2008-09, Part 4: Is Achievement Improving and Are Gaps Narrowing for Title I Students? Maryland

ERIC Educational Resources Information Center

Center on Education Policy, 2011

2011-01-01

This paper profiles Maryland's test score trends through 2008-09. In 2004, 82% of non-Title I 4th graders and 61% of Title I 4th graders scored at the proficient level on the state reading test. In 2009, 90% of non-Title I 4th graders and 78% of Title I 4th graders scored at the proficient level in reading. Between 2004 and 2009, the percentage…

State Test Score Trends through 2008-09, Part 4: Is Achievement Improving and Are Gaps Narrowing for Title I Students? Massachusetts

ERIC Educational Resources Information Center

Center on Education Policy, 2011

2011-01-01

This paper profiles Massachusetts's test score trends through 2008-09. In 2006, 59% of non-Title I 4th graders and 29% of Title I 4th graders scored at the proficient level on the state reading test. In 2009, 64% of non-Title I 4th graders and 31% of Title I 4th graders scored at the proficient level in reading. Between 2006 and 2009, the…

CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production.

PubMed

Romagnani, Paola; Maggi, Laura; Mazzinghi, Benedetta; Cosmi, Lorenzo; Lasagni, Laura; Liotta, Francesco; Lazzeri, Elena; Angeli, Roberta; Rotondi, Mario; Filì, Lucia; Parronchi, Paola; Serio, Mario; Maggi, Enrico; Romagnani, Sergio; Annunziato, Francesco

2005-12-01

Two variants of the CXCR3 receptor exist, one (CXCR3-A) reactive with CXCL9, CXCL10, and CXCL11 and the other (CXCR3-B) also reactive with CXCL4. Both variants are contemporarily expressed by human T cells. We sought to investigate the in vitro effects of CXCL10 and CXCL4 on the production of TH1 or TH2 cytokines. The cytokine profile of antigen-specific human CD4+ T-cell lines obtained in the absence or presence of CXCL10 or CXCL4 was evaluated by means of quantitative RT-PCR, flow cytometry, and ELISA. CXCL10 upregulated IFN-gamma and downregulated IL-4, IL-5, and IL-13 production, whereas CXCL4 downregulated IFN-gamma and upregulated TH2 cytokines. Similar effects were also observed on polyclonally activated pure naive CD4+ T cells. The opposite effects of CXCL10 and CXCL4 on TH1 and TH2 cytokine production were inhibited by an anti-CXCR3 antibody able to neutralize both CXCR3-A and CXCR3-B and were apparently related to the activation of distinct signal transduction pathways. Moreover, CXCL10 upregulated mRNA levels of T-box expressed in T cells and downregulated GATA-3 expression, whereas CXCL4 downregulated T-box expressed in T cells and upregulated GATA-3. Finally, CXCL4, but not CXCL10, induced direct activation of IL-5 and IL-13 promoters. CXCL10 and CXCL4 exert opposite effects on the production of human TH1 and TH2 cytokines, likely through their respective interaction with CXCR3-A or CXCR3-B and the consequent activation of different signal transduction pathways. This might represent an internal regulatory pathway of TH cell responses and might contribute to the modulation of chronic inflammatory reactions, including allergy.

Leveraging Twitter to gauge evacuation compliance: Spatiotemporal analysis of Hurricane Matthew.

PubMed

Martín, Yago; Li, Zhenlong; Cutter, Susan L

2017-01-01

Hurricane Matthew was the deadliest Atlantic storm since Katrina in 2005 and prompted one of the largest recent hurricane evacuations along the Southeastern coast of the United States. The storm and its projected landfall triggered a massive social media reaction. Using Twitter data, this paper examines the spatiotemporal variability in social media response and develops a novel approach to leverage geotagged tweets to assess the evacuation responses of residents. The approach involves the retrieval of tweets from the Twitter Stream, the creation and filtering of different datasets, and the statistical and spatial processing and treatment to extract, plot and map the results. As expected, peak Twitter response was reached during the pre-impact and preparedness phase, and decreased abruptly after the passage of the storm. A comparison between two time periods-pre-evacuation (October 2th-4th) and post-evacuation (October 7th-9th)-indicates that 54% of Twitter users moved away from the coast to a safer location, with observed differences by state on the timing of the evacuation. A specific sub-state analysis of South Carolina illustrated overall compliance with evacuation orders and detailed information on the timing of departure from the coast as well as the destination location. These findings advance the use of big data and citizen-as-sensor approaches for public safety issues, providing an effective and near real-time alternative for measuring compliance with evacuation orders.

Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites - FY 2014 First Quarterly Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Sanborn, Scott E.; Simmons, Kevin L.

2014-02-19

The CRADA between PNNL, Autodesk, Toyota and Magna has been effective since October 28th, 2013. The whole team including CRADA and subcontract partners kicked off the project technically on November 1st, 2013. This report describes work performed during the first quarter of FY 2014. The following technical progresses have been made toward project milestones: 1) The project kickoff meeting was organized at PlastiComp, Inc. in Winona on November 13th, 2013 involving all the project partners. During this meeting the research plan and Gantt chart were discussed and refined. The coordination of the research activities among the partners was also discussedmore » to ensure that the deliverables and timeline will be met. 2) Autodesk delivered a research version of ASMI to PNNL for process modeling using this tool under the project. PNNL installed this research version on a PNNL computer and tested it. Currently, PNNL is using ASMI to prepare the models for PlastiComp plaques. 3) PlastiComp has compounded long carbon-fiber reinforced polypropylene and polyamide 6,6 compounds for rheological and thermal characterization tests by the Autodesk laboratories in Melbourne, Australia. 4) Initial mold flow analysis was carried out by PlastiComp to confirm that the 3D complex part selected by Toyota as a representative automotive part is moldable. 5) Toyota, Magna, PlastiComp and PNNL finalized the planning for molding the Toyota 3D complex part. 6) Purdue University worked with PNNL to update and specify the test matrix for characterization of fiber length/orientation. 7) Purdue University developed tools to automate the data collection and analysis of fiber length and orientation measurements. 8) Purdue University designed and specified equipment to replace the need for equipment using the technology established by the University of Leeds at General Motors.« less

Color Duplex Assessment of 4th and 5th Internal Mammary Artery Perforators: The Pedicles of the Medially Based Lower Pole Breast Flaps

PubMed Central

Abdel-Monem, Kareem; Elshahat, Ahmed; Abou-Gamrah, Sherif; Eldin Abol-Atta, Hossam; Abd Eltawab, Reda; Massoud, Karim

2012-01-01

Objective: Reconstruction of a breast after mastectomy using the contralateral lower pole breast flap is an appealing procedure because it uses the tissues that were going to be excised during reduction of the sound breast to achieve symmetry. Literature mentioned that these flaps are supplied by the lower internal mammary artery perforators (IMAPs) with no further details. The aim of this study was to determine the site, size, and number of the 4th and 5th IMAPs by using preoperative color Duplex ultrasound and intraoperative exploration. Method: Twenty breasts in 10 patients who presented for reduction mammoplasty were included in this study. Preoperative color duplex was used to determine IMAPs in the 4th and 5th intercostal spaces. These perforators were localized intraoperatively. Intravenous fluorescein injection was used to determine the perfusion of the lower pole breast flap on the basis of these perforators. Results: Statistically, the 4th IMAPs diameters were significantly larger than the 5th IMAPs diameters (P < .05). The lower pole breast flap was perfused through these perforators. Conclusion: Color Duplex ultrasound is an accurate tool to preoperatively determine the 4th and 5th IMAPs. PMID:22292100

ThMYC4E, candidate Blue aleurone 1 gene controlling the associated trait in Triticum aestivum

PubMed Central

Chen, Wenjie; Zhang, Bo; Wang, Daowen; Liu, Dengcai; Zhang, Huaigang

2017-01-01

Blue aleurone is a useful and interesting trait in common wheat that was derived from related species. Here, transcriptomes of blue and white aleurone were compared for isolating Blue aleurone 1 (Ba1) transferred from Thinopyrum ponticum. In the genes involved in anthocyanin biosynthesis, only a basic helix-loop-helix (bHLH) transcription factor, ThMYC4E, had a higher transcript level in blue aleurone phenotype, and was homologous to the genes on chromosome 4 of Triticum aestivum. ThMYC4E carried the characteristic domains (bHLH-MYC_N, HLH and ACT-like) of a bHLH transcription factor, and clustered with genes regulating anthocyanin biosynthesis upon phylogenetic analysis. The over-expression of ThMYC4E regulated anthocyanin biosynthesis with the coexpression of the MYB transcription factor ZmC1 from maize. ThMYC4E existed in the genomes of the addition, substitution and near isogenic lines with the blue aleurone trait derived from Th. ponticum, and could not be detected in any germplasm of T. urartu, T. monococcum, T. turgidum, Aegilops tauschii or T. aestivum, with white aleurone. These results suggested that ThMYC4E was candidate Ba1 gene controlling the blue aleurone trait in T. aestivum genotypes carrying Th. ponticum introgression. The ThMYC4E isolation aids in better understanding the genetic mechanisms of the blue aleurone trait and in its more effective use during wheat breeding. PMID:28704468

40 CFR 51.907 - For an area that fails to attain the 8-hour NAAQS by its attainment date, how does EPA interpret...

Code of Federal Regulations, 2011 CFR

2011-07-01

... to 1-year extensions of the attainment date if: (a) For the first 1-year extension, the area's 4th... extension, the area's 4th highest daily 8-hour value, averaged over both the original attainment year and... section, the area's 4th highest daily 8-hour average shall be from the monitor with the highest 4th...

40 CFR 51.907 - For an area that fails to attain the 8-hour NAAQS by its attainment date, how does EPA interpret...

Code of Federal Regulations, 2013 CFR

2013-07-01

... to 1-year extensions of the attainment date if: (a) For the first 1-year extension, the area's 4th... extension, the area's 4th highest daily 8-hour value, averaged over both the original attainment year and... section, the area's 4th highest daily 8-hour average shall be from the monitor with the highest 4th...

40 CFR 51.907 - For an area that fails to attain the 8-hour NAAQS by its attainment date, how does EPA interpret...

Code of Federal Regulations, 2012 CFR

2012-07-01

... to 1-year extensions of the attainment date if: (a) For the first 1-year extension, the area's 4th... extension, the area's 4th highest daily 8-hour value, averaged over both the original attainment year and... section, the area's 4th highest daily 8-hour average shall be from the monitor with the highest 4th...

THE FIRST LASING OF 193 NM SASE, 4TH HARMONIC HGHG AND ESASE AT THE NSLS SDL.

DOE Office of Scientific and Technical Information (OSTI.GOV)

WANG, X.J.; SHEN Y.; WATANABE, T.

2006-08-28

The first lasing of three types of single-pass high-gain FELs, SASE at 193 nm, 4th harmonic HGHG at 199 nm and ESASE at the Source Development Lab (SDL) of Brookhaven National Laboratory (BNL) is reported. The saturation of 4th harmonic HGHG and ESASE FELs was observed. We also observed the spectral broadening and instability of the 4th harmonic HGHG.

Polarization of T-helper lymphocytes toward the Th2 phenotype in uremic patients.

PubMed

Libetta, C; Rampino, T; Dal Canton, A

2001-08-01

T-helper (Th) lymphocytes consist of Th1 and Th2 subsets. Th1 cells are effectors of cell-mediated immunity and secrete interferon-gamma (IFN-gamma), which recruits new Th1 cells in cooperation with interleukin-12 (IL-12; produced by monocytes) and inhibits Th2 differentiation. Th2 cells produce IL-4 and IL-10, which inhibit IFN-gamma secretion and cell immunity. We investigated whether the impaired immune response in uremia is associated with an altered balance of Th1/Th2. Peripheral-blood mononuclear cells (PBMCs) were collected from patients with chronic renal failure (CRF) on conservative treatment (CRF patients), patients with end-stage renal disease (ESRD) on regular hemodialysis therapy (ESRD-HD patients), and healthy controls (CON). CD4(+) cells were isolated from PBMCs by negative selection using a magnetic labeling system. PBMCs and purified CD4(+) cells were cultured in Iscove's medium and Iscove's medium plus mitogens (phytohemagglutinin and lipopolysaccharide). IFN-gamma, IL-12, IL-4, and IL-10 were measured in supernatant. The constitutive release of IL-4 and IL-10 by PBMCs and CD4(+) cells of CRF and ESRD-HD patients was increased by five to eight times in comparison with CON (P < 0.001). Constitutive IFN-gamma release by PBMCs of ESRD-HD patients was undetectable, although they secreted an increased amount of IL-12. Mitogen-stimulated release of IFN-gamma by PBMCs and CD4(+) cells of CRF and ESRD-HD patients was blunted (average PBMCs: CON, 115.8 pg/2 x10(6) cells; CRF, 81.8 pg/2 x10(6) cells; ESRD-HD, 9.3 pg/2 x10(6) cells; CD4(+) cells: CON, 358.0 pg/5 x 10(5) cells; CRF, 165.4 pg/5 x 10(5) cells; ESRD-HD, 43.5 pg/5 x 10(5) cells). The ability of PBMCs of ESRD-HD patients to secrete IFN-gamma was recovered after IL-4 and IL-10 neutralization. Uremia is associated with a prevalence of Th1 over Th2 cells and a configuration of cytokine network that depresses cell-mediated immunity.

Studies of hydride formation and superconductivity in hydrides of alloys Th-M /M = La, Y, Ce, Zr and Bi/

NASA Technical Reports Server (NTRS)

Oesterreicher, H.; Clinton, J.; Misroch, M.

1977-01-01

In order to gain a better insight into both the unusual composition of ThH15 and its superconductivity, an experimental study was conducted to assess the influence of partial replacement of Th in Th4H15 by elements which allow for a systematic alteration of spatial and electronic effects. For this purpose, substituent elements with the same number of valence electrons (4) but of smaller size (Zr) as well as elements with a smaller number of valence electrons (3) and either larger (La) or smaller size (Y) were selected. A few data with Ce and Bi as substituent atoms are also included. The matrix alloys for hydriding were obtained by induction melting under Ar in water-cooled Cu boats. Superconducting transition temperatures are found to decrease on substitution for Th in Th4H15. Hydrides derived from LaH3 by substitution for La by Th do not become superconducting. It is suggested that superconductivity in Th4H15 is connected with a deviation from the exact stoichiometry of Th4H15. A model of unsatisfied valencies may be of more general validity in predicting superconductivity.

Dynamically-downscaled temperature and precipitation changes over Saskatchewan using the PRECIS model

NASA Astrophysics Data System (ADS)

Zhou, Xiong; Huang, Guohe; Wang, Xiuquan; Cheng, Guanhui

2018-02-01

In this study, dynamically-downscaled temperature and precipitation changes over Saskatchewan are developed through the Providing Regional Climates for Impacts Studies (PRECIS) model. It can resolve detailed features within GCM grids such as topography, clouds, and land use in Saskatchewan. The PRECIS model is employed to carry out ensemble simulations for projections of temperature and precipitation changes over Saskatchewan. Temperature and precipitation variables at 14 weather stations for the baseline period are first extracted from each model run. Ranges of simulated temperature and precipitation variables are then obtained through combination of maximum and minimum values calculated from the five ensemble runs. The performance of PRECIS ensemble simulations can be evaluated through checking if observations of current temperature at each weather station are within the simulated range. Future climate projections are analyzed over three time slices (i.e., the 2030s, 2050s, and 2080s) to help understand the plausible changes in temperature and precipitation over Saskatchewan in response to global warming. The evaluation results show that the PRECIS ensemble simulations perform very well in terms of capturing the spatial patterns of temperature and precipitation variables. The results of future climate projections over three time slices indicate that there will be an obvious warming trend from the 2030s, to the 2050s, and the 2080s over Saskatchewan. The projected changes of mean temperature over the whole Saskatchewan area is [0, 2] °C in the 2030s at 10th percentile, [2, 5.5] °C in the 2050s at 50th percentile, and [3, 10] °C in the 2090s at 90th percentile. There are no significant changes in the spatial patterns of the projected total precipitation from the 2030s to the end of this century. The minimum change of the projected total precipitation over the whole Province of Saskatchewan is most likely to be -1.3% in the 2030s, and -0.2% in the 2050s, while the minimum value would be -2.1% to the end of this century at 50th percentile.

33 CFR 117.733 - New Jersey Intracoastal Waterway.

Code of Federal Regulations, 2013 CFR

2013-07-01

...:40 p.m. until 11:15 p.m. to accommodate the annual July 4th fireworks show. Should inclement weather...:15 p.m. on July 5th to accommodate the annual July 4th fireworks show. (3) On the third or fourth.... until 11:15 p.m. to accommodate the annual July 4th fireworks show. Should inclement weather prevent the...

33 CFR 117.733 - New Jersey Intracoastal Waterway.

Code of Federal Regulations, 2012 CFR

2012-07-01

...:40 p.m. until 11:15 p.m. to accommodate the annual July 4th fireworks show. Should inclement weather...:15 p.m. on July 5th to accommodate the annual July 4th fireworks show. (3) On the third or fourth.... until 11:15 p.m. to accommodate the annual July 4th fireworks show. Should inclement weather prevent the...

Cognate interactions between helper T cells and B cells. IV. Requirements for the expression of effector phase activity by helper T cells.

PubMed

Bartlett, W C; McCann, J; Shepherd, D M; Roy, M; Noelle, R J

1990-12-15

After activation with anti-CD3, activated Th (THCD3), but not resting Th, fixed with paraformaldehyde induce B cell RNA synthesis when co-cultured with resting B cells. This activity is expressed by Th of both Th1 and Th2 subtypes, as well as a third Th clone that is not classified into either subtype. It is proposed that anti-CD3 activation of Th results in the expression of Th membrane proteins that trigger B cell cycle entry. Kinetic studies reveal that 4 to 8 h of activation with anti-CD3 is sufficient for ThCD3 to express B cell-activating function. However, activation of Th with anti-CD3 for extended periods of time results in reduced Th effector activity. Inhibition of Th RNA synthesis during the anti-CD3 activation period ablates the ability of ThCD3 to induce B cell cycle entry. This indicates that de novo synthesis of proteins is required for ThCD3 to express effector function. The ability of fixed ThCD3 to induce entry of B cell into cycle is not due to an increase in expression of CD3, CD4, LFA-1, ICAM-1, class I MHC or Thy-1. Other forms of Th activation (PMA and A23187, Con A) also induced Th effector function. Furthermore, purified plasma membranes from anti-CD3 activated, but not resting Th, induced resting B cells to enter cycle. The addition of IL-4, but not IL-2, IL-5, or IFN-gamma amplified the DNA synthetic response of B cells stimulated with PM from activated Th. Taken together these data indicate that de novo expression of Th surface proteins on activated Th is required for Th to induce B cell cycle entry into G1 and the addition of IL-4 is required for the heightened progression into S phase.

Climate change and runoff in south-western Australia

NASA Astrophysics Data System (ADS)

Silberstein, R. P.; Aryal, S. K.; Durrant, J.; Pearcey, M.; Braccia, M.; Charles, S. P.; Boniecka, L.; Hodgson, G. A.; Bari, M. A.; Viney, N. R.; McFarlane, D. J.

2012-12-01

SummaryThis paper presents the results of computer simulations of runoff from 13 major fresh and brackish river basins in south-western Australia (SWA) under climate projections obtained from 15 GCMs with three future global warming scenarios equivalent to global temperature rises of 0.7 °C, 1.0 °C and 1.3 °C by 2030. The objective was to apply an efficient methodology, consistent across a large region, to examine the implications of the best available projections in climate trends for future surface water resources. An ensemble of rainfall-runoff models was calibrated on stream flow data from 1975 to 2007 from 106 gauged catchments distributed throughout the basins of the study area. The sensitivity of runoff to projected changes in mean annual rainfall is examined using the climate 'elasticity' concept. Averaged across the study area, all 15 GCMs project declines in rainfall under all global warming scenarios with a median decline of 8% resulting in a median decline in runoff of 25%. Such uniformity in projections from GCMs is unusual. Over SWA the average annual runoff under the 5th wettest and 5th driest of the 45 projections of the 2030 climate declines by 10 and 42%, respectively. Under the 5th driest projection the runoff decline ranges from 53% in the northern region to 40% in the southern region. Strong regional variations in climate sensitivity are found with the proportional decline in runoff greatest in the northern region and the greatest volumetric declines in the wetter basins in the south. Since the mid 1970s stream flows into the major water supply reservoirs in SWA have declined by more than 50% following a 16% rainfall reduction. This has already had major implications for water resources planning and for the preservation of aquatic and riparian ecosystems in the region. Our results indicate that this reduction in runoff is likely to continue if future climate projections eventuate.

Suppressive effects of a novel CC chemokine receptor 4 antagonist on Th2 cell trafficking in ligand- and antigen-induced mouse models.

PubMed

Komiya, Takaki; Sugiyama, Tetsuya; Takeda, Kazuhiko; Watanabe, Noriki; Imai, Masamichi; Kokubo, Masaya; Tokuda, Natsuko; Ochiai, Hiroshi; Habashita, Hiromu; Shibayama, Shiro

2013-11-15

CC chemokine receptor 4 (CCR4) has been implicated as a preferential marker for T helper type 2 (Th2) cells, and is believed to be involved in the pathology of allergic diseases by controlling Th2 cell trafficking into inflamed tissues. The objective of the study was to characterize the pharmacological properties of E0001-163, a novel CCR4 antagonist. E0001-163 was tested in both in vitro chemotaxis assays as well as in vivo mouse models of CCR4 ligand-induced air pouch and antigen-induced airway inflammation by utilizing in vitro-polarized Th2 cells. In vitro, E0001-163 inhibited migratory response of human Th2-polarized cells to CCL22, a CCR4 ligand, with an IC50 value of 11.9 nM. E0001-163 significantly suppressed CCL22-induced Th2 cell trafficking into mouse air pouch in a dose-dependent manner at doses of 3 and 10mg/kg, suggesting that E0001-163 has an inhibitory effect on CCR4-mediated T cell trafficking in vivo. In addition, E0001-163 partially decreased Th2 cell trafficking and the level of IL-4 in the lungs in Th2-tansferred and ovalbumin (OVA)-challenged mice. T cell trafficking involves multiple chemokine receptors both in acute and chronic phases, and our findings suggest that CCR4, together with other chemokine receptors, may be involved in Th2 cell trafficking under disease conditions. © 2013 Elsevier B.V. All rights reserved.

GUE-70-14.10 mine research project, Guernsey County, Ohio : research implementation plan.

DOT National Transportation Integrated Search

2005-09-01

This project fulfilled a statewide need, as well as a local need. The statewide need was to generally : determine what geophysical, geotechnical and groundwater investigations could be used singlely, or in : conjunction with one another, to detect th...

Pooled nucleic acid testing increases the diagnostic yield of acute HIV infections in a high-risk population compared to 3rd and 4th generation HIV enzyme immunoassays.

PubMed

Krajden, Mel; Cook, Darrel; Mak, Annie; Chu, Ken; Chahil, Navdeep; Steinberg, Malcolm; Rekart, Michael; Gilbert, Mark

2014-09-01

We compared a 3rd generation (gen) and two 4th gen HIV enzyme immunoassays (EIA) to pooled nucleic acid testing (PNAT) for the identification of pre- and early seroconversion acute HIV infection (AHI). 9550 specimens from males >18 year from clinics attended by men who have sex with men were tested by Siemens ADVIA Centaur(®) HIV 1/O/2 (3rd gen) and HIV Combo (4th gen), as well as by Abbott ARCHITECT(®) HIV Ag/Ab Combo (4th gen). Third gen non-reactive specimens were also tested by Roche COBAS(®) Ampliprep/COBAS® TaqMan HIV-1 Test v.2 in pools of 24 samples. Sensitivity and specificity of the three EIAs for AHI detection were compared. 7348 persons contributed 9435 specimens and had no evidence of HIV infection, 79 (94 specimens) had established HIV infection, 6 (9 specimens) had pre-seroconversion AHI and 9 (12 specimens) had early seroconversion AHI. Pre-seroconversion AHI cases were not detected by 3rd gen EIA, whereas 2/6 (33.3%) were detected by Siemens 4th gen, 4/6 (66.7%) by Abbott 4th gen and 6/6 (100%) by PNAT. All three EIAs and PNAT detected all individuals with early seroconversion AHI. Overall sensitivity/specificity for the EIAs relative to WB or NAT resolved infection status was 93.6%/99.9% for Siemens 3rd gen, 95.7%/99.7% for Siemens 4th gen and 97.9%/99.2% for Abbott 4th gen. While both 4th gen EIAs demonstrated improved sensitivity for AHI compared to 3rd gen EIA, PNAT identified more AHI cases than either 4th gen assay. PNAT is likely to remain a useful strategy to identify AHI in high-risk populations. Copyright © 2014 Elsevier B.V. All rights reserved.

Selective biosorption of thorium (IV) from aqueous solutions by ginkgo leaf.

PubMed

Huang, Yaoyao; Hu, Yang; Chen, Lvcun; Yang, Tao; Huang, Hanfang; Shi, Runping; Lu, Peng; Zhong, Chenghua

2018-01-01

Low-cost biosorbents (ginkgo leaf, osmanthus leaf, banyan leaf, magnolia leaf, holly leaf, walnut shell, and grapefruit peel) were evaluated in the simultaneous removal of La3+, Ce3+, Pr3+, Nd3+, Sm3+, Eu3+, Gd3+, Yb3+, Lu3+, UO22+, Th4+, Y3+, Co2+, Zn2+, Ni2+, and Sr2+ from aqueous solutions. In single metal systems, all adsorbents exhibited good to excellent adsorption capacities toward lanthanides and actinides. In a simulated multicomponent mixed solution study, higher selectivity and efficiency were observed for Th4+ over other metal cations, with ginkgo leaves providing the highest adsorptivity (81.2%) among the seven biosorbents. Through optimization studies, the selectivity of Th4+ biosorption on ginkgo leaf was found to be highly pH-dependent, with optimum Th4+ removal observed at pH 4. Th4+ adsorption was found to proceed rapidly with an equilibrium time of 120 min and conform to pseudo-second-order kinetics. The Langmuir isotherm model best described Th4+ biosorption, with a maximum monolayer adsorption capacity of 103.8 mg g-1. Thermodynamic calculations indicated that Th4+ biosorption was spontaneous and endothermic. Furthermore, the physical and chemical properties of the adsorbent were determined by scanning electron microscopy, Brunauer-Emmett-Teller, X-ray powder diffraction, and Fourier transform infrared analysis. The biosorption of Th from a real sample (monazite mineral) was studied and an efficiency of 90.4% was achieved from nitric acid at pH 4 using ginkgo leaves.

Ab initio studies of Th3N4, Th2N3 and Th2N2(NH)

NASA Astrophysics Data System (ADS)

Obodo, K. O.; Chetty, N.

2014-09-01

Using density functional theory within the Perdew-Burke-Ernzerhof generalized gradient approximation [GGA (PBE)] implemented in the VASP codes, we investigate the structural, elastic and electronic properties of Th3N4, Th2N3 and Th2N2(NH). The calculated structural properties of these thorium-based nitrides are in good agreement with experimental data. We observe that all the Th-N based compounds that we considered are energetically favorable and elastically stable. We find that Th3N4 is semiconducting with a band gap of 1.59 eV, which compares well with the experimental band gap of 1.7 eV and we find Th2N3 to be metallic. Th2N2(NH), which is crystallographically equivalent to Th2N3, is insulating with a band gap of 2.12 eV. This is due to the -(NH) group that effects a shifting of the energy bands that results in the opening of a gap at the Fermi-level. The Th-N based compounds that we considered are predominantly ionic.

AAPG-SEPM Gulf of Mexico type-well project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Slatt, R.M.; Christopher, R.C.; Katz, B.J.

1992-12-01

In 1991, The American Association of Petroleum Geologists (AAPG) published a regional stratigraphic cross section and accompanying seismic line that extends from the south flank of the Ouachita tectonic belt in southern Arkansas (lat. 34.15'N) to south of the 28th parallel in the High Island area, South Addition Block of offshore Gulf of Mexico. The cross section shows chronostratigraphic correlations, lithostratigraphy, and generalized structural relations common to the central Gulf Coast and mid-continent region. The section has been published in three large sheets, each representing approximately 425 statue mi of geographic coverage. As an outgrowth of this project, AAPG, jointlymore » with the Society of Sedimentary Geology (SEPM), organized and sponsored a project through their respective Research Committees on biostratigraphic, lithostratigraphic, and organic geochemical analyses of cuttings from key wells tied to the cross section. Separate splits of samples were sent to volunteers for the following analyses: (1) binocular microscope lithology analysis, (2) detailed biostratigraphy, (3) organic geochemistry, and (4) clay mineralogy by x-ray diffraction (XRD).« less

Changes in expression of T-helper (Th) 1- and Th2-associated chemokine receptors on peripheral blood lymphocytes and plasma concentrations of their ligands, interferon-inducible protein-10 and thymus and activation-regulated chemokine, after antithyroid drug administration in hyperthyroid patients with Graves' disease.

PubMed

Inukai, Yoshihisa; Momobayashi, Atsushi; Sugawara, Naoto; Aso, Yoshimasa

2007-06-01

Although Graves' disease is considered an autoantibody-mediated, T-helper 2 (Th2)-dominant disease, Th1-dominance may prevail in its initial phase. We longitudinally investigated Th1/Th2 balance in untreated hyperthyroid patients with Graves' disease after treatment of methimazole (MMI), an antithyroid drug. University clinic outpatients were studied prospectively. Subjects included 23 untreated hyperthyroid patients with Graves' disease and 17 age-matched control subjects. Before and after treatment, we measured Th1- and Th2-associated chemokine receptors (CXCR)3 and CCR4, on peripheral blood lymphocytes using flow cytometry, as well as plasma concentrations of their ligands, interferon-inducible protein (IP)-10 and thymus and activation-regulated chemokine (TARC). The percentage of CXCR3-expressing cells among CD4+T lymphocytes and plasma IP-10 was significantly higher in hyperthyroid Graves' disease patients than in controls. At 12 and 24 weeks after initiation of MMI, percentage of CXCR3-expressing CD4+T lymphocytes had decreased significantly, while the percentage of CCR4-expressing CD4+T lymphocytes had increased significantly at 24 weeks. The CXCR3/CCR4 ratio had decreased significantly at 24 weeks. Plasma concentrations of IP-10 had decreased significantly at 12 and 24 weeks. Plasma concentrations of TARC also had decreased significantly at 24 weeks. In hyperthyroid patients with Graves' disease in the active phase, Th1 cells rather than Th2 cells predominated among peripheral blood lymphocytes. After initiation of MMI, an ongoing transition from Th1 to Th2 dominance occurred.

Comparison of Visual Assessment of Breast Density in BI-RADS 4th and 5th Editions With Automated Volumetric Measurement.

PubMed

Youk, Ji Hyun; Kim, So Jung; Son, Eun Ju; Gweon, Hye Mi; Kim, Jeong-Ah

2017-09-01

The purpose of this study was to compare visual assessments of mammographic breast density by radiologists using BI-RADS 4th and 5th editions in correlation with automated volumetric breast density measurements. A total of 337 consecutive full-field digital mammographic examinations with standard views were retrospectively assessed by two radiologists for mammographic breast density according to BI-RADS 4th and 5th editions. Fully automated measurement of the volume of fibroglandular tissue and total breast and percentage breast density was performed with a commercially available software program. Interobserver and intraobserver agreement was assessed with kappa statistics. The distributions of breast density categories for both editions of BI-RADS were compared and correlated with volumetric data. Interobserver agreement on breast density category was moderate to substantial (κ = 0.58-0.63) with use of BI-RADS 4th edition and substantial (κ = 0.63-0.66) with use of the 5th edition but without significant difference between the two editions. For intraobserver agreement between the two editions, the distributions of density category were significantly different (p < 0.0001), the proportions of dense breast increased, and the proportion of fatty breast decreased with use of the 5th edition compared with the 4th edition (p < 0.0001). All volumetric breast density data, including percentage breast density, were significantly different among density categories (p < 0.0001) and had significant correlation with visual assessment for both editions of BI-RADS (p < 0.01). Assessment using BI-RADS 5th edition revealed a higher proportion of dense breast than assessment using BI-RADS 4th edition. Nevertheless, automated volumetric density assessment had good correlation with visual assessment for both editions of BI-RADS.

Upregulation of bacterial-specific Th1 and Th17 responses that are enriched in CXCR5+CD4+ T cells in non-small cell lung cancer.

PubMed

Ma, Qin-Yun; Huang, Da-Yu; Zhang, Hui-Jun; Wang, Shaohua; Chen, Xiao-Feng

2017-11-01

The microbial community in the mucosal surfaces is involved in the development of human cancers, including gastric cancer and colorectal cancer. The respiratory tract in the lung also hosts a distinctive microbial community, but the correlation between this community and lung cancer is largely unknown. Here, we examined the Th1 and Th17 responses toward several bacterial antigens, in CD4 + T cells sourced from the peripheral blood (PB), the lung cancer (LC) tissue, and the gastrointestinal (GI) tract of non-small cell lung cancer (NSCLC) patients. Compared to healthy controls, the NSCLC patients presented significantly higher frequencies of Th1 and Th17 cells reacting to Streptococcus salivarius and S. agalactiae, in the PB, LC, and GI tract. Further investigation showed that the upregulation in anti-bacteria response was likely antigen-specific for two reasons. Firstly, the frequencies of Th1 and Th17 cells reacting to Escherichia coli, a typical GI bacterium, were not upregulated in the PB and the LC of NSCLC patients. Secondly, the S. salivarius and S. agalactiae responses could be partially blocked by Tü39, a MHC class II blocking antibody, suggesting that antigen-specific interaction between CD4 + T cells and antigen-presenting cells was required. We also found that S. salivarius and S. agalactiae could potently activate the monocytes to secrete higher levels of interleukin (IL)-6, IL-12, and tumor necrosis factor, which were Th1- and Th17-skewing cytokines. Interestingly, whereas CXCR5 + CD4 + T cells represented <20% of total CD4 + T cells, they represented 17%-82% of bacteria-specific Th1 or Th17 cells. Together, these data demonstrated that NSCLC patients presented a significant upregulation of bacterial-specific Th1 and Th17 responses that were enriched in CXCR5 + CD4 + T cells. Copyright © 2017 Elsevier B.V. All rights reserved.

Evaluation of Life Sciences and Social Sciences Course Books in Term of Societal Sexuality

ERIC Educational Resources Information Center

Aykac, Necdet

2012-01-01

This study aims to evaluate primary school Life Sciences (1st, 2nd, and 3rd grades) and Social Sciences (4th, 5th, and 6th grades) course books in terms of gender discrimination. This study is a descriptive study aiming to evaluate the primary school Life Sciences (1st, 2nd, 3rd grades) and Social Sciences (4th, 5th, and 6th grades) course books…

Interleukin-4 production by Follicular Helper T cells requires the conserved Il4 enhancer HS V

PubMed Central

Vijayanand, Pandurangan; Seumois, Grégory; Simpson, Laura J.; Abdul-Wajid, Sarah; Baumjohann, Dirk; Panduro, Marisella; Huang, Xiaozhu; Interlandi, Jeneen; Djuretic, Ivana M.; Brown, Daniel R.; Sharpe, Arlene H.; Rao, Anjana; Ansel, K. Mark

2012-01-01

SUMMARY Follicular helper T cells (Tfh cells) are the major producers of interleukin-4 (IL-4) in secondary lymphoid organs where humoral immune responses develop. Il4 regulation in Tfh cells appears distinct from the classical T helper 2 (Th2) cell pathway, but the underlying molecular mechanisms remain largely unknown. We found that HS V (also known as CNS2), a 3’ enhancer in the Il4 locus, is essential for IL-4 production by Tfh cells. Mice lacking HS V display marked defects in Th2 humoral immune responses, as evidenced by abrogated IgE and sharply reduced IgG1 production in vivo. In contrast, effector Th2 cells that are involved in tissue responses were far less dependent on HS V. HS V facilitated removal of repressive chromatin marks during Th2 and Tfh cell differentiation, and increased accessibility of the Il4 promoter. Thus Tfh and Th2 cells utilize distinct but overlapping molecular mechanisms to regulate Il4, a finding with important implications for understanding the molecular basis of Th2 mediated allergic diseases. PMID:22326582

Immobilization of Alkali Metal Fluorides via Recrystallization in a Cationic Lamellar Material, [Th(MoO4)(H2O)4Cl]Cl·H2O.

PubMed

Lin, Jian; Bao, Hongliang; Qie, Meiying; Silver, Mark A; Yue, Zenghui; Li, Xiaoyun; Zhu, Lin; Wang, Xiaomei; Zhang, Linjuan; Wang, Jian-Qiang

2018-06-05

Searching for cationic extended materials with a capacity for anion exchange resulted in a unique thorium molybdate chloride (TMC) with the formula of [Th(MoO 4 )(H 2 O) 4 Cl]Cl·H 2 O. The structure of TMC is composed of zigzagging cationic layers [Th(MoO 4 )(H 2 O) 4 Cl] + with Cl - as interlamellar charge-balancing anions. Instead of performing ion exchange, alkali thorium fluorides were formed after soaking TMC in AF (A = Na, K, and Cs) solutions. The mechanism of AF immobilization is elucidated by the combination of SEM-EDS, PXRD, FTIR, and EXAFS spectroscopy. It was observed that four water molecules coordinating with the Th 4+ center in TMC are vulnerable to competition with F - , due to the formation of more favorable Th-F bonds compared to Th-OH 2 . This leads to a single crystal-to-polycrystalline transformation via a pathway of recrystallization to form alkali thorium fluorides.

Transcription factor-dependent chromatin remodeling of Il18r1 during Th1 and Th2 differentiation 1

PubMed Central

Yu, Qing; Chang, Hua-Chen; Ahyi, Ayele-Nati N.; Kaplan, Mark H.

2008-01-01

The IL-18Rα chain is expressed on Th1 but not Th2 cells. We have recently shown that Stat4 is an important component of programming the Il18r1 locus (encoding IL-18Rα) for maximal expression in Th1 cells. Il18r1 is reciprocally repressed during Th2 development. In this report we demonstrate that the establishment of DNase hypersensitivity patterns that are distinct among undifferentiated CD4 T cells, Th1 and Th2 cells. Stat6 is required for the repression of Il18r1 expression and in Stat6-deficient Th2 cultures, mRNA levels, histone acetylation and H3K4 methylation levels are intermediate between levels observed in Th1 and Th2 cells. Despite the repressive effects of IL-4 during Th2 differentiation, we observed only modest binding of Stat6 to the Il18r1 locus. In contrast, we observed robust GATA-3 binding to a central region of the locus where DNase hypersensitivity sites overlapped with conserved non-coding sequences in Il18r1 introns. Ectopic expression of GATA-3 in differentiated Th1 cells repressed Il18r1 mRNA and surface expression of IL-18Rα. These data provide further mechanistic insight into transcription factor dependent establishment of Th subset-specific patterns of gene expression. PMID:18714006

Performance of a Combined System Using an X-Ray FEL Oscillator and a High-Gain FEL Amplifier

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, L.; Lindberg, R.; Kim, K. -J.

The LCLS-II at SLAC will feature a 4 GeV CW superconducting (SC) RF linac [1] that can potentially drive a 5th harmonic X-Ray FEL Oscillator (XFELO) to produce fully coherent, 1 MW photon pulses with a 5 meV bandwidth at 14.4 keV [2]. The XFELO output can serve as the input seed signal for a high-gain FEL amplifier employing fs electron beams from the normal conducting SLAC linac, thereby generating coherent, fs x-ray pulses with TW peak powers using a tapered undulator after saturation [3]. Coherent, intense output at several tens of keV will also be feasible if one considersmore » a harmonic generation scheme. Thus, one can potentially reach the 42 keV photon energy required for the MaRIE project [4] by beginning with an XFELO operating at the 3rd harmonic to produce 14.0 keV photons using a 12 GeV SCRF linac, and then subsequently using the high-gain harmonic generation scheme to generate and amplify the 3th harmonic at 42 keV [5]. We report extensive GINGER simulations that determine an optimized parameter set for the combined system.« less

Synergistic immunosuppression by candida in HIV infection: a cytokine based analysis.

PubMed

Bajaj, J S; Singh, A; Aggarwal, S K; Chattopadhya, D; Baveja, U K

2000-03-01

Candida is a common opportunistic pathogen in HIV infection and is regarded a signal infection for progression to AIDS. Cytokine imbalances between Th1/Th2 groups have been described in both candida and HIV infections. A study was undertaken to assess the role of candida in furthering immunosuppression in HIV infection based on cytokine levels and CD4 cell counts. 30 Indian subjects were enrolled; 10 HIV positive patients with and 10 without mucosal candidiasis and 10 age matched controls. Th1 cytokines; interleukin (IL) 2, IL 12 and interferon (IFN) gamma, Th2 cytokines; IL 4, IL 6, IL 10 and tumor necrosis factor (TNF) alpha with CD 4 cell counts were estimated using ELISA in all subjects. CD4 cell counts were reduced in both patient groups as compared to controls; significantly more in patients with both HIV and candida infections. There was a decrease in Th1 cytokine levels in all patients; lower levels of Th1 cytokines were seen in patients with both infections. Among the Th2 cytokines, there was a significant increase in the levels of IL 6, IL 10 and TNF alpha in both patient groups; IL 10 and TNF alpha values were significantly raised in patients with dual HIV and candida infections as compared to the other patients. There was no difference in IL 4 values across the subject groups. A positive correlation between CD4 cell counts and Th1 cytokine levels and a negative correlation with Th2 cytokines were noted; these were stronger in patients with both HIV and candidiasis. Thus, there was a Th1/Th2 cytokine imbalance with CD4 cell count reduction in all HIV infected patients, which was more pronounced in patients with both infections. It can be concluded that, owing to the depressed CD4 cell count and Th1 response and increased Th2 cytokines in patients with both candidiasis and HIV as compared to patients with only HIV candidiasis may have a synergistic immunosuppressive effect with HIV in patients with dual infections.

[Changes of agroecosystem services value under effects of land consolidation].

PubMed

Zhang, Zhen; Gao, Jin-Quan; Wei, Chao-Fu

2010-03-01

This paper quantitatively described the changes of agroecosystem functions before (2003) and after (2007) the implementation of Gaolong land consolidation project in Hechuan of Chongqing. Engineering design and shadow price were integrated to quantify the effects of the project on the functions, and cost-benefit analysis was used to further explain the economic meanings of the functions, and to analyze the changes of the agroecosystem services value under effects of the project. Compared with that before the land consolidation, the agroecosystem services value after the land consolidation was somewhat improved, with the largest increment of nutrient cycling function and the smallest change of soil conservation function. In the implementation of the project, the changes of the agroecosystem services value induced by farmland water conservancy, field road building, and land-leveling engineering mainly manifested in the change of disturbance function. From the 7th to 35th year after the project, the cost benefit would have a rapid increase, and tended to be stable after then, giving a weak ecological pressure and little services value loss, and benefiting the improvement of regional ecological environment.

Middle School Mathematics Teachers' Perceptions of Differentiated Instruction for English Language Learners

ERIC Educational Resources Information Center

Murray, Vicki

2013-01-01

English language learner (ELL) mathematics students at a California middle school did not meet Adequate Yearly Progress (AYP) toward state standards in 2010. The purpose of this project study was to examine 6th and 7th grade mathematics teachers' perceptions regarding differentiated instruction for ELL students' specific academic needs and to…

The Training of Music Teachers in Colombia: A Descriptive Analysis

ERIC Educational Resources Information Center

Nayibe Cárdenas Soler, Ruth; Lorenzo Quiles, Oswaldo; Hargreaves, David J.

2015-01-01

This study is an evaluative analysis of 13 Music Education programs in Colombia that provide training for secondary school music teachers for 6th to 11th grade in the Colombian education system. The study utilized an analysis matrix from the International Research Project ALFA II-0448-A, which developed a similar study with Latin American and…

Anthropology: Focus Upon Ethnic Studies.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. Bureau of General Education Curriculum Development.

This course syllabus is designed to serve as the basis for a one-semester, 12th grade anthropology course or a one-year, 12th grade ethnic studies course. As such it can be used as the culminating course in a kindergarten-grade 12 sequence. The ethnic studies component is based on data collected by an Italo-American Curriculum Studies Project and…

Using the Sociology of Associations to Rethink STEM Education

ERIC Educational Resources Information Center

Buxton, Cory; Harper, Susan; Payne, Yolanda Denise; Allexsaht-Snider, Martha

2017-01-01

Using three constructs taken from Latour's 2005 book, "Reassembling the Social," we consider our work in 2 contexts that were part of a project to support science teachers working with English learners: an 8th-grade physical science class in a summer science enrichment academy, and a 6th-grade Earth science class in a public middle…

Selected Papers from the International Conference on College Teaching and Learning (10th, Jacksonville, Florida, April 1999).

ERIC Educational Resources Information Center

Chambers, Jack A., Ed.

These 20 papers were selected from those presented at the 10th International Conference on College Teaching and Learning. Papers have the following titles and authors: (1) "Case It! A Project to Integrate Collaborative Case-Based Learning into International Undergraduate Biology Curricula" (Bergland, Klyczek, Lundeberg, Mogen, Johnson); (2) "The…

75 FR 52689 - Multifamily Housing Reform and Affordability Act: Projects Eligible for a Restructuring Plan...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-27

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT 24 CFR Part 401 [Docket No. FR-5304-P-01] RIN 2502... Counsel, Department of Housing and Urban Development, 451 7th Street, SW., Room 10276, Washington, DC..., Department of Housing and Urban Development, 451 7th Street, SW., Room 10276, Washington, DC 20410-0500. 2...

Translating Music Intelligibly: Musical Paraphrase in the Long 20th Century

ERIC Educational Resources Information Center

Orosz, Jeremy White

2013-01-01

This dissertation is a study of the practice of musical paraphrase in the long 20th century. Musical paraphrase is defined as the adaptation, alteration, or embellishment of musical material, often borrowed from another source. My project is built around a single guiding question: If a composer borrows music from another source and alters it for…

From Trash to Treasure--Rebuilding a '66 Vespa

ERIC Educational Resources Information Center

Boissonnault, Tom

2010-01-01

This article describes how the author got his 8th-grade students thinking about greener modes of transportation--and got them excited about technology education--in the course of rebuilding a badly damaged 1966 Vespa scooter. This turned out to be a wonderful project because it included almost the entire 8th grade, and showed students that…

TEACHERS' GUIDES. WORLD HISTORY FOR THE ACADEMICALLY TALENTED. ADVANCED PLACEMENT EUROPEAN HISTORY.

ERIC Educational Resources Information Center

AUGSPURGER, EVERETT F.; AND OTHERS

PREPARED BY TEACHERS AND SUPERVISORS WORKING WITH A 2-YEAR DEMONSTRATION PROJECT, THIS DOCUMENT CONTAINS GUIDES FOR A WORLD HISTORY COURSE (PREHISTORY TO EARLY 20TH CENTURY) FOR THE GIFTED AND AN ADVANCED PLACEMENT COURSE IN EUROPEAN HISTORY (ANCIENT CIVILIZATION TO EARLY 20TH CENTURY). STUDENTS ARE EXPECTED TO STUDY HISTORICAL ISSUES AND DEVELOP…