78 FR 1901 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

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2013-08-14

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2011-10-17

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2013-05-09

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2012-05-23

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2012-05-23

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Amelioration of cadmium- and mercury-induced liver and kidney damage in rats by genetically engineered probiotic Escherichia coli Nissle 1917 producing pyrroloquinoline quinone with oral supplementation of citric acid.

PubMed

Raghuvanshi, Ruma; Chaudhari, Archana; Kumar, G Naresh

2016-01-01

Antioxidants, chelating agents, and probiotics are used to manage the toxic effects of cadmium (Cd) and mercury (Hg). The aim of this study was to investigate the combined effects of antioxidants, chelating agents, and probiotics against heavy metal toxicity. Genetically modified probiotic Escherichia coli Nissle 1917 (EcN-20) producing a potent water soluble antioxidant pyrroloquinoline quinone (PQQ) was supplemented with oral citric acid and compared with another genetically modified probiotic EcN-21 producing PQQ and citric acid against oxidative stress induced by Cd and Hg. Rats were independently given 100 ppm Cd and 80 ppm Hg in drinking water for 4 wk. EcN-20 was found to be more effective than EcN-2 (EcN strain with genomic integration of vgb and gfp genes) with orally given PQQ against oxidative stress induced by Cd and Hg. EcN-20 supplemented with oral citric acid was more effective against Cd and Hg toxicity compared with EcN-2+citric acid (oral), EcN-2+PQQ (oral), EcN-2+PQQ (oral)+citric acid (oral), EcN-20, and EcN-21. However, protection shown by EcN-21 was similar to EcN-20. The combination therapy involving probiotic EcN-20 producing PQQ with citric acid given orally was found to be a moderately effective strategy against toxicity induced by Cd and Hg, whereas the protective effect of EcN-21 was the same as EcN-20. Copyright © 2016 Elsevier Inc. All rights reserved.

Survival of the probiotic Escherichia coli Nissle 1917 (EcN) in the gastrointestinal tract given in combination with oral mesalamine to healthy volunteers.

PubMed

Joeres-Nguyen-Xuan, Thai Hoa; Boehm, Stephan Karl; Joeres, Lars; Schulze, Juergen; Kruis, Wolfgang

2010-02-01

Mesalamine and the probiotic E. coli Nissle 1917 (EcN) are both effective agents for the treatment of ulcerative colitis. A combined therapy may have more than additive efficacy. However, mesalamine may have antimicrobial effects on EcN. In this prospective, randomized, double-blind, placebo-controlled study, 48 healthy volunteers took EcN in a run-in phase for 17 days (5-50 x 10(9) viable bacteria od). If stool samples became positive for EcN, volunteers received combination treatment with EcN plus either mesalamine (1500 mg twice a day) or placebo for 1 week. Fecal samples were further tested for EcN in 2- to 3-day intervals until a maximum of 48 weeks after treatment. Patient diaries, blood, and urine were checked to assess safety, compliance, and tolerance. During run-in, viable EcN were detected in 45 of the 48 volunteers (94%); 2 volunteers were positive before taking EcN. From days 1 to 7 of combination treatment (n = 40), the number of EcN-positive volunteers varied between 70% and 80% in the mesalamine group and between 85% and 95% in the placebo group. Differences between the groups were not significant (normal approximation: day 3, P > 0.15; day 5, P > 0.25; day 7, P > 0.076). At treatment discontinuation, 16 of 20 volunteers in the mesalamine group and 15 of 20 volunteers in the placebo group were EcN positive, whereas this figure dropped continuously up to week 12 after discontinuation (mesalamine, 7 of 20; placebo, 4 of 20). No differences between the groups were seen with regard to tolerance and safety. The combination of EcN and mesalamine has no significant effect on the survival of EcN in healthy volunteers.

78 FR 39386 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

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2013-07-01

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2013-07-01

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Genetically Engineered Escherichia coli Nissle 1917 Synbiotics Reduce Metabolic Effects Induced by Chronic Consumption of Dietary Fructose

PubMed Central

Somabhai, Chaudhari Archana; Raghuvanshi, Ruma; Nareshkumar, G.

2016-01-01

Aims To assess protective efficacy of genetically modified Escherichia coli Nissle 1917 (EcN) on metabolic effects induced by chronic consumption of dietary fructose. Materials and Methods EcN was genetically modified with fructose dehydrogenase (fdh) gene for conversion of fructose to 5-keto-D-fructose and mannitol-2-dehydrogenase (mtlK) gene for conversion to mannitol, a prebiotic. Charles foster rats weighing 150–200 g were fed with 20% fructose in drinking water for two months. Probiotic treatment of EcN (pqq), EcN (pqq-glf-mtlK), EcN (pqq-fdh) was given once per week 109 cells for two months. Furthermore, blood and liver parameters for oxidative stress, dyslipidemia and hyperglycemia were estimated. Fecal samples were collected to determine the production of short chain fatty acids and pyrroloquinoline quinone (PQQ) production. Results EcN (pqq-glf-mtlK), EcN (pqq-fdh) transformants were confirmed by restriction digestion and functionality was checked by PQQ estimation and HPLC analysis. There was significant increase in body weight, serum glucose, liver injury markers, lipid profile in serum and liver, and decrease in antioxidant enzyme activity in high-fructose-fed rats. However the rats treated with EcN (pqq-glf-mtlK) and EcN (pqq-fdh) showed significant reduction in lipid peroxidation along with increase in serum and hepatic antioxidant enzyme activities. Restoration of liver injury marker enzymes was also seen. Increase in short chain fatty acids (SCFA) demonstrated the prebiotic effects of mannitol and gluconic acid. Conclusions Our study demonstrated the effectiveness of probiotic EcN producing PQQ and fructose metabolizing enzymes against the fructose induced hepatic steatosis suggesting that its potential for use in treating fructose induced metabolic syndrome. PMID:27760187

Role of F1C fimbriae, flagella, and secreted bacterial components in the inhibitory effect of probiotic Escherichia coli Nissle 1917 on atypical enteropathogenic E. coli infection.

PubMed

Kleta, Sylvia; Nordhoff, Marcel; Tedin, Karsten; Wieler, Lothar H; Kolenda, Rafal; Oswald, Sibylle; Oelschlaeger, Tobias A; Bleiss, Wilfried; Schierack, Peter

2014-05-01

Enteropathogenic Escherichia coli (EPEC) is recognized as an important intestinal pathogen that frequently causes acute and persistent diarrhea in humans and animals. The use of probiotic bacteria to prevent diarrhea is gaining increasing interest. The probiotic E. coli strain Nissle 1917 (EcN) is known to be effective in the treatment of several gastrointestinal disorders. While both in vitro and in vivo studies have described strong inhibitory effects of EcN on enteropathogenic bacteria, including pathogenic E. coli, the underlying molecular mechanisms remain largely unknown. In this study, we examined the inhibitory effect of EcN on infections of porcine intestinal epithelial cells with atypical enteropathogenic E. coli (aEPEC) with respect to single infection steps, including adhesion, microcolony formation, and the attaching and effacing phenotype. We show that EcN drastically reduced the infection efficiencies of aEPEC by inhibiting bacterial adhesion and growth of microcolonies, but not the attaching and effacing of adherent bacteria. The inhibitory effect correlated with EcN adhesion capacities and was predominantly mediated by F1C fimbriae, but also by H1 flagella, which served as bridges between EcN cells. Furthermore, EcN seemed to interfere with the initial adhesion of aEPEC to host cells by secretion of inhibitory components. These components do not appear to be specific to EcN, but we propose that the strong adhesion capacities enable EcN to secrete sufficient local concentrations of the inhibitory factors. The results of this study are consistent with a mode of action whereby EcN inhibits secretion of virulence-associated proteins of EPEC, but not their expression.

Decreased functional connectivity in an executive control network is related to impaired executive function in Internet gaming disorder.

PubMed

Dong, Guangheng; Lin, Xiao; Potenza, Marc N

2015-03-03

Resting brain spontaneous neural activities across cortical regions have been correlated with specific functional properties in psychiatric groups. Individuals with Internet gaming disorder (IGD) demonstrate impaired executive control. Thus, it is important to examine executive control networks (ECNs) during resting states and their relationships to executive control during task performance. Thirty-five IGD and 36 healthy control participants underwent a resting-state fMRI scan and performed a Stroop task inside and outside of the MRI scanner. Correlations between Stroop effect and functional connectivity among ECN regions of interest (ROIs) were calculated within and between groups. IGD subjects show lower functional connectivity in ECNs than do HC participants during resting state; functional-connectivity measures in ECNs were negatively correlated with Stroop effect and positively correlated with brain activations in executive-control regions across groups. Within groups, negative trends were found between Stroop effect and functional connectivity in ECNs in IGD and HC groups, separately; positive trends were found between functional connectivity in ECNs and brain activations in Stroop task in IGD and HC groups, separately. Higher functional connectivity in ECNs may underlie better executive control and may provide resilience with respect to IGD. Lower functional connectivity in ECNs may represent an important feature in understanding and treating IGD. Copyright © 2013 Elsevier Inc. All rights reserved.

Reinventing the PN Junction: Dimensionality Effects on Tunneling Switches

DTIC Science & Technology

2012-05-11

Figure 4.7. Finally we need to define the band tail density of states:    > < = −− Vp qVEE Vp p EEe EE ED OVp , ,1 )( /)( (4.3.10...Cn qVEE Cn n EEe EE ED OCn , ,1 )( /)( (4.3.11) Here EVp is the valence band edge on the p side and ECn is the conduction band...semiconductor will occur at the oxide semiconductor interface and is given by the boundary condition SSOXOX EE  εε = . This means that the maximum

Quantification of biogenic volatile organic compounds with a flame ionization detector using the effective carbon number concept

DOE PAGES

Faiola, C. L.; Erickson, M. H.; Fricaud, V. L.; ...

2012-08-10

Biogenic volatile organic compounds (BVOCs) are emitted into the atmosphere by plants and include isoprene, monoterpenes, sesquiterpenes, and their oxygenated derivatives. These BVOCs are among the principal factors influencing the oxidative capacity of the atmosphere in forested regions. BVOC emission rates are often measured by collecting samples onto adsorptive cartridges in the field and then transporting these samples to the laboratory for chromatographic analysis. One of the most commonly used detectors in chromatographic analysis is the flame ionization detector (FID). For quantitative analysis with an FID, relative response factors may be estimated using the effective carbon number (ECN) concept. Themore » purpose of this study was to determine the ECN for a variety of terpenoid compounds to enable improved quantification of BVOC measurements. A dynamic dilution system was developed to make quantitative gas standards of VOCs with mixing ratios from 20–55 ppb. For each experiment using this system, one terpene standard was co-injected with an internal reference, n-octane, and analyzed via an automated cryofocusing system interfaced to a gas chromatograph flame ionization detector and mass spectrometer (GC/MS/FID). The ECNs of 16 compounds (14 BVOCs) were evaluated with this approach, with each test compound analyzed at least three times. The difference between the actual carbon number and measured ECN ranged from -24% to -2%. Furthermore, the difference between theoretical ECN and measured ECN ranged from -22% to 9%. Measured ECN values were within 10% of theoretical ECN values for most terpenoid compounds.« less

In Vitro Evaluation of the Impact of the Probiotic E. coli Nissle 1917 on Campylobacter jejuni's Invasion and Intracellular Survival in Human Colonic Cells.

PubMed

Helmy, Yosra A; Kassem, Issmat I; Kumar, Anand; Rajashekara, Gireesh

2017-01-01

Campylobacter jejuni is a leading cause of bacterial food poisoning in humans. Due to the rise in antibiotic-resistant Campylobacter , there exists a need to develop antibiotic-independent interventions to control infections in humans. Here, we evaluated the impact of Escherichia coli Nissle 1917 (EcN), a probiotic strain, on C. jejuni's invasion and intracellular survival in polarized human colonic cells (HT-29). To further understand how EcN mediates its impact, the expression of 84 genes associated with tight junctions and cell adhesion was profiled in HT-29 cells after treatment with EcN and challenge with C. jejuni . The pre-treatment of polarized HT-29 cells with EcN for 4 h showed a significant effect on C. jejuni 's invasion (∼2 log reduction) of the colonic cells. Furthermore, no intracellular C. jejuni were recovered from EcN pre-treated HT-29 cells at 24 h post-infection. Other probiotic strains tested had no significant impact on C. jejuni invasion and intracellular survival. C. jejuni decreased the expression of genes associated with epithelial cells permeability and barrier function in untreated HT-29 cells. However, EcN positively affected the expression of genes that are involved in enhanced intestinal barrier function, decreased cell permeability, and increased tight junction integrity. The results suggest that EcN impedes C. jejuni invasion and subsequent intracellular survival by affecting HT-29 cells barrier function and tight junction integrity. We conclude that EcN might be a viable alternative for controlling C. jejuni infections.

The Probiotic Escherichia coli Strain Nissle 1917 Combats Lambdoid Bacteriophages stx and λ.

PubMed

Bury, Susanne; Soundararajan, Manonmani; Bharti, Richa; von Bünau, Rudolf; Förstner, Konrad U; Oelschlaeger, Tobias A

2018-01-01

Shiga toxin (Stx) producing E. coli (STEC) such as Enterohemorrhagic E. coli (EHEC) are the major cause of foodborne illness in humans. In vitro studies showed the probiotic Escherichia coli strain Nissle 1917 (EcN) to efficiently inhibit the production of Stx. Life threatening EHEC strains as for example the serotype O104:H4, responsible for the great outbreak in 2011 in Germany, evolutionary developed from certain E. coli strains which got infected by stx2 -encoding lambdoid phages turning the E. coli into lysogenic and subsequently Stx producing strains. Since antibiotics induce stx genes and Stx production, EHEC infected persons are not recommended to be treated with antibiotics. Therefore, EcN might be an alternative medication. However, because even commensal E. coli strains might be converted into Stx-producers after becoming host to a stx encoding prophage, we tested EcN for stx -phage genome integration. Our experiments revealed the resistance of EcN toward not only stx -phages but also against lambda-phages. This resistance was not based on the lack of or by mutated phage receptors. Rather it involved the expression of a phage repressor ( pr ) gene of a defective prophage in EcN which was able to partially protect E. coli K-12 strain MG1655 against stx and lambda phage infection. Furthermore, we observed EcN to inactivate phages and thereby to protect E. coli K-12 strains against infection by stx - as well as lambda-phages. Inactivation of lambda-phages was due to binding of lambda-phages to LamB of EcN whereas inactivation of stx -phages was caused by a thermostable protein of EcN. These properties together with its ability to inhibit Stx production make EcN a good candidate for the prevention of illness caused by EHEC and probably for the treatment of already infected people.

Neuroprotection against 6-OHDA toxicity in PC12 cells and mice through the Nrf2 pathway by a sesquiterpenoid from Tussilago farfara.

PubMed

Lee, Joohee; Song, Kwangho; Huh, Eugene; Oh, Myung Sook; Kim, Yeong Shik

2018-06-01

Oxidative stress plays a key role in neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Therefore, the nuclear factor-E2-related factor 2 (Nrf2), a key regulator of the antioxidative response, is considered to be important as a therapeutic target for neurodegenerative diseases. We investigated the underlying mechanism of Nrf2-mediated neuroprotective effects against oxidative stress in the PC12 cell line by 7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone (ECN), one of the sesquiterpenoids in Farfarae Flos. Pretreatment of PC12 cells with ECN had a protective effect against hydrogen peroxide (H 2 O 2 )- or 6-hydroxydopamine (6-OHDA)-induced cytotoxicity. ECN upregulated the ARE-luciferase activity and induced the mRNA expression of Nrf2 and antioxidant enzyme heme oxygenase-1 (HO-1). Knockdown of Nrf2 by small, interfering RNA (siRNA) abrogated the upregulation of HO-1, indicating that ECN had induced HO-1 via the Nrf2 pathway. Pretreatment with the thiol reducing agents, N-acetylcysteine (NAC) or dithiothreitol (DTT), attenuated Nrf2 activation and HO-1 expression. However, the non-thiol reducing antioxidant, Trolox, failed to inhibit HO-1 induction by ECN. These results suggest that ECN may directly interact with Kelch-like ECH-associated protein 1 (Keap1) and modify critical cysteine thiols present in the proteins responsible for Nrf2-mediated upregulation of HO-1. In a 6-OHDA-induced mouse model of PD, administration of ECN ameliorated motor impairments and dopaminergic neuronal damage. Taken together, ECN exerts neuroprotective effects by activating the Nrf2/HO-1 signaling pathway in both PC12 cells and mice. Thus, ECN, as an Nrf2 activator, could be an attractive therapeutic candidate for the neuroprotection or treatment of neurodegenerative diseases. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Econazole imprinted textiles with antifungal activity.

PubMed

Hossain, Mirza Akram; Lalloz, Augustine; Benhaddou, Aicha; Pagniez, Fabrice; Raymond, Martine; Le Pape, Patrice; Simard, Pierre; Théberge, Karine; Leblond, Jeanne

2016-04-01

In this work, we propose pharmaceutical textiles imprinted with lipid microparticles of Econazole nitrate (ECN) as a mean to improve patient compliance while maintaining drug activity. Lipid microparticles were prepared and characterized by laser diffraction (3.5±0.1 μm). Using an optimized screen-printing method, microparticles were deposited on textiles, as observed by scanning electron microscopy. The drug content of textiles (97±3 μg/cm(2)) was reproducible and stable up to 4 months storage at 25 °C/65% Relative Humidity. Imprinted textiles exhibited a thermosensitive behavior, as witnessed by a fusion temperature of 34.8 °C, which enabled a larger drug release at 32 °C (temperature of the skin) than at room temperature. In vitro antifungal activity of ECN textiles was compared to commercial 1% (wt/wt) ECN cream Pevaryl®. ECN textiles maintained their antifungal activity against a broad range of Candida species as well as major dermatophyte species. In vivo, ECN textiles also preserved the antifungal efficacy of ECN on cutaneous candidiasis infection in mice. Ex vivo percutaneous absorption studies demonstrated that ECN released from pharmaceutical textiles concentrated more in the upper skin layers, where the fungal infections develop, as compared to dermal absorption of Pevaryl®. Overall, these results showed that this technology is promising to develop pharmaceutical garments textiles for the treatment of superficial fungal infections. Copyright © 2016 Elsevier B.V. All rights reserved.

75 FR 78794 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-16

... (Direct) \\4\\ or through the ECN Translator.\\5\\ Members and non-members will receive the first ten (10... sessions will not apply to ECN Translator sessions to incent members and non-members to use Direct Sessions... the Exchange's secondary data center. \\5\\ The ECN translator allows a Member or non-member who...

75 FR 78791 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-16

... (Direct) \\4\\ or through the ECN Translator.\\5\\ Members and non-members will receive the first ten (10... sessions will not apply to ECN Translator sessions to incent members and non-members to use Direct Sessions... the Exchange's secondary data center. \\5\\ The ECN translator allows a Member or non-member who...

Critical size of ego communication networks

NASA Astrophysics Data System (ADS)

Wang, Qing; Gao, Jian; Zhou, Tao; Hu, Zheng; Tian, Hui

2016-06-01

With the help of information and communication technologies, studies on the overall social networks have been extensively reported recently. However, investigations on the directed Ego Communication Networks (ECNs) remain insufficient, where an ECN stands for a sub network composed of a centralized individual and his/her direct contacts. In this paper, the directed ECNs are built on the Call Detail Records (CDRs), which cover more than 7 million people of a provincial capital city in China for half a year. Results show that there is a critical size for ECN at about 150, above which the average emotional closeness between ego and alters drops, the balanced relationship between ego and network collapses, and the proportion of strong ties decreases. This paper not only demonstrate the significance of ECN size in affecting its properties, but also shows accordance with the “Dunbar's Number”. These results can be viewed as a cross-culture supportive evidence to the well-known Social Brain Hypothesis (SBH).

Prophylaxis of acute respiratory infections via improving the immune system in late preterm newborns with E. coli strain Nissle 1917: a controlled pilot trial.

PubMed

Aryayev, Mykola L; Senkivska, Liudmyla I; Bredeleva, Nataliya K; Talashova, Irina V

2018-01-01

Acute respiratory infections (ARIs), caused by the high level of immaturity of the immune system, are a major cause of morbidity in preterm newborns. The probiotic Escherichia coli strain Nissle 1917 (EcN) is well known for its immuno-modulatory properties and may therefore enhance the immune competence. Thus, EcN administration may provide a promising possibility to decrease the risk of ARIs in this vulnerable group of children. However, clinical data supporting or refuting this hypothesis are, to our knowledge, not available. Therefore, the aim of the presented pilot trial was to collect first data on the efficacy and safety of EcN treatment to prevent ARIs in late preterm newborns. Right after birth, 62 late preterm newborns were included into an open-labeled, controlled 4-week trial with two parallel groups and a follow-up phase until the age of 1 year. All children of the treatment group received an EcN suspension orally for 3 weeks, whereas the control group was only observed. Primary efficacy variable was the number of participants with at least one ARI during the first 28 days of life. Secondary efficacy variables were the number of ARIs and the number and duration of hospitalizations caused by ARIs during the first year of life. The number of participants with at least one ARI during the first 28 days of life was significantly lower in the group treated with EcN compared to that in the control group. Although only of exploratory nature, analyses of secondary efficacy variables suggest that EcN treatment may also reduce the average number of ARIs, the average number of hospitalizations caused by ARIs, and the mean duration of such hospitalizations. There is also some evidence that early EcN treatment may have long-term benefits on newborns' health status. The present pilot trial provides first evidence that EcN is able to reduce the incidence of ARIs in the neonatal period of late preterm newborns. Additionally, EcN is characterized by an excellent individual biocompatibility in the absence of adverse drug reactions. Limitations of the current trial are discussed and recommendations for future confirmatory studies are made. ClinicalTrials.gov identifier: NCT01540162; retrospectively registered on 16 February 2012.

Entericidin Is Required for a Probiotic Treatment (Enterobacter sp. Strain C6-6) To Protect Trout from Cold-Water Disease Challenge

PubMed Central

Schubiger, Carla B.; Orfe, Lisa H.; Sudheesh, Ponnerassery S.; Cain, Kenneth D.; Shah, Devendra H.

2014-01-01

Flavobacterium psychrophilum causes bacterial cold-water disease in multiple fish species, including salmonids. An autochthonous Enterobacter strain (C6-6) inhibits the in vitro growth of F. psychrophilum, and when ingested as a putative probiotic, it provides protection against injection challenge with F. psychrophilum in rainbow trout. In this study, low-molecular-mass (≤3 kDa) fractions from both Enterobacter C6-6 and Escherichia coli K-12 culture supernatants inhibited the growth of F. psychrophilum. The ≤3-kDa fraction from Enterobacter C6-6 was analyzed by SDS-PAGE, and subsequent tandem mass spectroscopy identified EcnB, which is a small membrane lipoprotein that is a putative pore-forming toxin. Agar plate diffusion assays demonstrated that ecnAB knockout strains of both Enterobacter C6-6 and E. coli K-12 no longer inhibited F. psychrophilum (P < 0.001), while ecnAB-complemented knockout strains recovered the inhibitory phenotype (P < 0.001). In fish experiments, the engineered strains (C6-6 ΔecnAB and C6-6 ΔecnAB) and the wild-type strain (C6-6) were added to the fish diet every day for 38 days. On day 11, the fish were challenged by injection with a virulent strain of F. psychrophilum (CSF 259-93). Fish that were fed C6-6 had significantly longer survival than fish fed the ecnAB knockout strain (P < 0.0001), while fish fed the complemented knockout strain recovered the probiotic phenotype (P = 0.61). This entericidin is responsible for the probiotic activity of Enterobacter C6-6, and it may present new opportunities for therapeutic and prophylactic treatments against similarly susceptible pathogens. PMID:25381243

Investigating the relationship between subjective drug craving and temporal dynamics of the default mode network, executive control network, and salience network in methamphetamine dependents using rsfMRI

NASA Astrophysics Data System (ADS)

Soltanian-Zadeh, Somayyeh; Hossein-Zadeh, Gholam-Ali; Shahbabaie, Alireza; Ekhtiari, Hamed

2016-03-01

Resting state functional connectivity (rsFC) studies using fMRI provides a great deal of knowledge on the spatiotemporal organization of the brain. The relationships between and within a number of resting state functional networks, namely the default mode network (DMN), salience network (SN) and executive control network (ECN) have been intensely studied in basic and clinical cognitive neuroscience [1]. However, the presumption of spatial and temporal stationarity has mostly restricted the assessment of rsFC [1]. In this study, sliding window correlation analysis and k-means clustering were exploited to examine the temporal dynamics of rsFC of these three networks in 24 abstinent methamphetamine dependents. Afterwards, using canonical correlation analysis (CCA) the possible relationship between the level of self-reported craving and the temporal dynamics was examined. Results indicate that the rsFC transits between 6 discrete "FC states" in the meth dependents. CCA results show that higher levels of craving are associated with higher probability of transiting from state 4 to 6 (positive FC of DMN-ECN getting weak and negative FC of DMN-SN appearing) and staying in state 4 (positive FC of DMN-ECN), lower probability of staying in state 2 (negative FC of DMN-ECN), transiting from state 4 to 2 (change of positive FC of DMN-ECN to negative FC), and transiting from state 3 to 5 (appearance of negative FC of DMN-SN and positive FC of DMN-ECN with the presence of negative FC of SN-ECN). Quantitative measures of temporal dynamics in large-scale brain networks could bring new added values to increase potentials for applications of rsfMRI in addiction medicine.

Non-toxic engineered carbon nanodiamond concentrations induce oxidative/nitrosative stress, imbalance of energy metabolism, and mitochondrial dysfunction in microglial and alveolar basal epithelial cells.

PubMed

Fresta, Claudia G; Chakraborty, Aishik; Wijesinghe, Manjula B; Amorini, Angela M; Lazzarino, Giacomo; Lazzarino, Giuseppe; Tavazzi, Barbara; Lunte, Susan M; Caraci, Filippo; Dhar, Prajnaparamita; Caruso, Giuseppe

2018-02-14

Engineered nanoparticles are finding a wide spectrum of biomedical applications, including drug delivery and capacity to trigger cytotoxic phenomena, potentially useful against tumor cells. The full understanding of their biosafety and interactions with cell processes is mandatory. Using microglial (BV-2) and alveolar basal epithelial (A549) cells, in this study we determined the effects of engineered carbon nanodiamonds (ECNs) on cell viability, nitric oxide (NO) and reactive oxygen species (ROS) production, as well as on energy metabolism. Particularly, we initially measured decrease in cell viability as a function of increasing ECNs doses, finding similar cytotoxic ECN effects in the two cell lines. Subsequently, using apparently non-cytotoxic ECN concentrations (2 µg/mL causing decrease in cell number < 5%) we determined NO and ROS production, and measured the concentrations of compounds related to energy metabolism, mitochondrial functions, oxido-reductive reactions, and antioxidant defences. We found that in both cell lines non-cytotoxic ECN concentrations increased NO and ROS production with sustained oxidative/nitrosative stress, and caused energy metabolism imbalance (decrease in high energy phosphates and nicotinic coenzymes) and mitochondrial malfunctioning (decrease in ATP/ADP ratio).These results underline the importance to deeply investigate the molecular and biochemical changes occurring upon the interaction of ECNs (and nanoparticles in general) with living cells, even at apparently non-toxic concentration. Since the use of ECNs in biomedical field is attracting increasing attention the complete evaluation of their biosafety, toxicity and/or possible side effects both in vitro and in vivo is mandatory before these highly promising tools might find the correct application.

Escherichia coli Nissle 1917 enhances bioavailability of serotonin in gut tissues through modulation of synthesis and clearance

PubMed Central

Nzakizwanayo, Jonathan; Dedi, Cinzia; Standen, Guy; Macfarlane, Wendy M.; Patel, Bhavik A.; Jones, Brian V.

2015-01-01

Accumulating evidence shows indigenous gut microbes can interact with the human host through modulation of serotonin (5-HT) signaling. Here we investigate the impact of the probiotic Escherichia coli Nissle 1917 (EcN) on 5-HT signalling in gut tissues. Ex-vivo mouse ileal tissue sections were treated with either EcN or the human gut commensal MG1655, and effects on levels of 5-HT, precursors, and metabolites, were evaluated using amperometry and high performance liquid chromatography with electrochemical detection (HPLC-EC). Exposure of tissue to EcN cells, but not MG1655 cells, was found to increase levels of extra-cellular 5-HT. These effects were not observed when tissues were treated with cell-free supernatant from bacterial cultures. In contrast, when supernatant recovered from untreated ileal tissue was pre-incubated with EcN, the derivative cell-free supernatant was able to elevate 5-HT overflow when used to treat fresh ileal tissue. Measurement of 5-HT precursors and metabolites indicated EcN also increases intracellular 5-HTP and reduces 5-HIAA. The former pointed to modulation of tryptophan hydroxylase-1 to enhance 5-HT synthesis, while the latter indicates an impact on clearance into enterocytes through SERT. Taken together, these findings show EcN is able to enhance 5-HT bioavailability in ileal tissues through interaction with compounds secreted from host tissues. PMID:26616662

Entericidin is required for a probiotic treatment (Enterobacter sp. strain C6-6) to protect trout from cold-water disease challenge.

PubMed

Schubiger, Carla B; Orfe, Lisa H; Sudheesh, Ponnerassery S; Cain, Kenneth D; Shah, Devendra H; Call, Douglas R

2015-01-01

Flavobacterium psychrophilum causes bacterial cold-water disease in multiple fish species, including salmonids. An autochthonous Enterobacter strain (C6-6) inhibits the in vitro growth of F. psychrophilum, and when ingested as a putative probiotic, it provides protection against injection challenge with F. psychrophilum in rainbow trout. In this study, low-molecular-mass (≤3 kDa) fractions from both Enterobacter C6-6 and Escherichia coli K-12 culture supernatants inhibited the growth of F. psychrophilum. The ≤3-kDa fraction from Enterobacter C6-6 was analyzed by SDS-PAGE, and subsequent tandem mass spectroscopy identified EcnB, which is a small membrane lipoprotein that is a putative pore-forming toxin. Agar plate diffusion assays demonstrated that ecnAB knockout strains of both Enterobacter C6-6 and E. coli K-12 no longer inhibited F. psychrophilum (P < 0.001), while ecnAB-complemented knockout strains recovered the inhibitory phenotype (P < 0.001). In fish experiments, the engineered strains (C6-6 ΔecnAB and C6-6 ΔecnAB) and the wild-type strain (C6-6) were added to the fish diet every day for 38 days. On day 11, the fish were challenged by injection with a virulent strain of F. psychrophilum (CSF 259-93). Fish that were fed C6-6 had significantly longer survival than fish fed the ecnAB knockout strain (P < 0.0001), while fish fed the complemented knockout strain recovered the probiotic phenotype (P = 0.61). This entericidin is responsible for the probiotic activity of Enterobacter C6-6, and it may present new opportunities for therapeutic and prophylactic treatments against similarly susceptible pathogens. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

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Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

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Excited State Properties of 3'-Hydroxyechinenone in Solvents and in the Orange Carotenoid Protein from Synechocystis sp. PCC 6803

DOE Office of Scientific and Technical Information (OSTI.GOV)

Niedzwiedzki, Dariusz M.; Liu, Haijun; Blankenship, Robert E.

The orange carotenoid protein (OCP) is a 35 kDa water-soluble protein involved in a photoprotective mechanism of the photosynthetic apparatus of cyanobacteria. The OCP contains a single molecule of the carotenoid 3'-hydroxyechinenone (3'-hECN). We have performed transient absorption studies at 77 K in the visible and near-infrared spectral ranges on 3'-hECN in solvent glass and in both inactive (orange) and active (red) forms of OCP. In the OCP the cryogenic temperature prohibited the protein from spontaneous conversion between activity stages and allowed us to study well-defined spectral forms of the protein. The studies show that each form of the OCPmore » consists of two protein subpopulations having different photophysical properties of the bound 3'-hECN. At 77 K the inactive OCP reveals two lifetimes of the first excited state of 3'-hECN of 5.2 and 11 ps while in the active form of OCP these are 3.2 and 7.1 ps. We have also determined the energy of the first excited singlet state of 3'-hECN in long-lived subpopulations of both OCP forms at 77 K. This is 13,750 cm –1 in the inactive OCP and 12,300 cm -1 in the active OCP. Shortening of the lifetime and decrease of the energy of the first excited singlet state of 3'-hECN confirm the lengthening of the effective conjugation of the carotenoid upon the inactive-to-active conversion of OCP.« less

Altered coupling of default-mode, executive-control and salience networks in Internet gaming disorder.

PubMed

Zhang, J T; Ma, S-S; Yan, C-G; Zhang, S; Liu, L; Wang, L-J; Liu, B; Yao, Y-W; Yang, Y-H; Fang, X-Y

2017-09-01

Recently, a triple-network model suggested the abnormal interactions between the executive-control network (ECN), default-mode network (DMN) and salience network (SN) are important characteristics of addiction, in which the SN plays a critical role in allocating attentional resources toward the ECN and DMN. Although increasing studies have reported dysfunctions in these brain networks in Internet gaming disorder (IGD), interactions between these networks, particularly in the context of the triple-network model, have not been investigated in IGD. Thus, we aimed to assess alterations in the inter-network interactions of these large-scale networks in IGD, and to associate the alterations with IGD-related behaviors. DMN, ECN and SN were identified using group-level independent component analysis (gICA) in 39 individuals with IGD and 34 age and gender matched healthy controls (HCs). Then alterations in the SN-ECN and SN-DMN connectivity, as well as in the modulation of ECN versus DMN by SN, using a resource allocation index (RAI) developed and validated previously in nicotine addiction, were assessed. Further, associations between these altered network coupling and clinical assessments were also examined. Compared with HCs, IGD had significantly increased SN-DMN connectivity and decreased RAI in right hemisphere (rRAI), and the rRAI in IGD was negatively associated with their scores of craving. These findings suggest that the deficient modulation of ECN versus DMN by SN might provide a mechanistic framework to better understand the neural basis of IGD and might provide novel evidence for the triple-network model in IGD. Copyright © 2017. Published by Elsevier Masson SAS.

EFG Ribbon Technology

NASA Astrophysics Data System (ADS)

Schwirtlich, I. A.

Since the beginning of solar cell development based on crystalline silicon, there have been efforts to produce wafers directly from the melt instead of through crystallization of ingots. Ingots require slicing into the blocs and wafers which form the basis of solar cells. In the last 30 years, several dozen processes have been published that describe a variety of concepts. Only few of these processes could be developed to an acceptable degree of technical maturity. Among those successful technologies are the Dendritic Web process, the Edge Supported Pulling (ESP) process and the Edge-Defined-Film-Fed-Growth (EFG) process. The EFG Process was originally developed by Mobil Solar and, since the mid-1990s, belongs to SCHOTT Solar GmbH and its predecessors, respectively. The Ribbon Growth on Substrate (RGS) process was originally developed by Bayer AG and is now in a pilot project at the ECN, Petten. Considering the past 20 to 30 years, the EFG process has reached the most advanced state in terms of industrialization.

Escherichia coli Nissle 1917 in Ulcerative Colitis Treatment: Systematic Review and Meta-analysis.

PubMed

Losurdo, Giuseppe; Iannone, Andrea; Contaldo, Antonella; Ierardi, Enzo; Di Leo, Alfredo; Principi, Mariabeatrice

2015-12-01

Escherichia coli Nissle 1917 (EcN) has been recommended as a therapeutic tool for ulcerative colitis (UC) treatment. However, to date, no meta-analysis has been performed on this topic. We performed a literature search on PubMed, MEDLINE, Science Direct and EMBASE. We evaluated success rates for induction of remission, relapse rates and side effects, expressed as Intention-To-Treat. Odd ratios (OR), pooled OR and 95% confidence intervals (CI) were calculated, based on the Mantel-Haenszel method. Heterogeneity was assessed by using the χ2 and I2 statistics and, if present, a random-effects model was adopted. We selected six eligible trials, with 719 patients, 390 assigned to the study group and 329 to the control group. EcN induced remission in 61.6% of cases, while in the control group (mesalazine) the remission was achieved in 69.5% of cases, with a mean difference of 7.9%. The pooled OR was 0.92 (95% CI 0.15-9.66, p=0.93). A single study showed a better performance of EcN than the placebo. A relapse of the disease occurred in 36.8% in the EcN group and in 36.1% in the control group (mesalazine), with a mean difference of 0.8%, OR=1.07, with a 95% CI of 0.70-1.64 (p=0.74). Side effects were comparable (OR=1.44, 95% CI 0.80-2.59, p=0.22). EcN is equivalent to mesalazine in preventing disease relapse, thus confirming current guideline recommendations. EcN seems to be as effective as controls in inducing remission and therefore, its use cannot be recommended as in one study the comparison was performed against placebo. Further studies may be helpful for this subject.

Evaluating the Record of the Coalition Provisional Authority’s Macroeconomic Reforms in Iraq

DTIC Science & Technology

2011-12-01

Economic Review 6, no. 3 (1992): 355, http://www.cedeplar.ufmg.br/ economia /disciplinas/ecn933a/crocco/Operacao_governanca_Bancos_Centrai s... economia /disciplinas/ecn933a/crocco/Operacao_governanca_Bancos_Centrai s/CUKIERMANAWEBBNEYAPTIMeas.pdf. 34 This finding is consistent with empirical

Role and mechanisms of action of Escherichia coli Nissle 1917 in the maintenance of remission in ulcerative colitis patients: An update

PubMed Central

Scaldaferri, Franco; Gerardi, Viviana; Mangiola, Francesca; Lopetuso, Loris Riccardo; Pizzoferrato, Marco; Petito, Valentina; Papa, Alfredo; Stojanovic, Jovana; Poscia, Andrea; Cammarota, Giovanni; Gasbarrini, Antonio

2016-01-01

Ulcerative colitis (UC) is a chronic inflammatory disease, whose etiology is still unclear. Its pathogenesis involves an interaction between genetic factors, immune response and the “forgotten organ”, Gut Microbiota. Several studies have been conducted to assess the role of antibiotics and probiotics as additional or alternative therapies for Ulcerative Colitis. Escherichia coli Nissle (EcN) is a nonpathogenic Gram-negative strain isolated in 1917 by Alfred Nissle and it is the active component of microbial drug Mutaflor® (Ardeypharm GmbH, Herdecke, Germany and EcN, Cadigroup, In Italy) used in many gastrointestinal disorder including diarrhea, uncomplicated diverticular disease and UC. It is the only probiotic recommended in ECCO guidelines as effective alternative to mesalazine in maintenance of remission in UC patients. In this review we propose an update on the role of EcN 1917 in maintenance of remission in UC patients, including data about efficacy and safety. Further studies may be helpful for this subject to further the full use of potential of EcN. PMID:27350728

Escherichia coli Nissle 1917 protects gnotobiotic pigs against human rotavirus by modulating pDC and NK-cell responses.

PubMed

Vlasova, Anastasia N; Shao, Lulu; Kandasamy, Sukumar; Fischer, David D; Rauf, Abdul; Langel, Stephanie N; Chattha, Kuldeep S; Kumar, Anand; Huang, Huang-Chi; Rajashekara, Gireesh; Saif, Linda J

2016-10-01

Lactobacillus rhamnosus GG (LGG), a gram-positive lactic acid bacterium, is one of the most widely used probiotics; while fewer gram-negative probiotics including Escherichia coli Nissle 1917 (EcN) are characterized. A mechanistic understanding of their individual and interactive effects on human rotavirus (HRV) and immunity is lacking. In this study, noncolonized, EcN-, LGG-, and EcN + LGG-colonized neonatal gnotobiotic (Gn) pigs were challenged with HRV. EcN colonization is associated with a greater protection against HRV, and induces the highest frequencies of plasmacytoid dendritic cells (pDCs), significantly increased NK-cell function and decreased frequencies of apoptotic and TLR4 + mononuclear cells (MNCs). Consistent with the highest NK-cell activity, splenic CD172 + MNCs (DC enriched fraction) of EcN-colonized pigs produced the highest levels of IL-12 in vitro. LGG colonization has little effect on the above parameters, which are intermediate in EcN + LGG-colonized pigs, suggesting that probiotics modulate each other's effects. Additionally, in vitro EcN-treated splenic or intestinal MNCs produce higher levels of innate, immunoregulatory and immunostimulatory cytokines, IFN-α, IL-12, and IL-10, compared to MNCs of pigs treated with LGG. These results indicate that the EcN-mediated greater protection against HRV is associated with potent stimulation of the innate immune system and activation of the DC-IL-12-NK immune axis. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Escherichia coli strain Nissle 1917-from bench to bedside and back: history of a special Escherichia coli strain with probiotic properties.

PubMed

Sonnenborn, Ulrich

2016-10-01

Among the gram-negative microorganisms with probiotic properties, Escherichia coli strain Nissle 1917 (briefly EcN) is probably the most intensively investigated bacterial strain today. Since nearly 100 years, the EcN strain is used as the active pharmaceutical ingredient in a licensed medicinal product that is distributed in Germany and several other countries. Over the last few decades, novel probiotic activities have been detected, which taken together are specific of this versatile E. coli strain. This review gives a short overview on the discovery and history of the EcN strain. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Educational Cultural Negotiators for Students of Color: A Descriptive Study of Racial Advocacy Leaders

ERIC Educational Resources Information Center

Warren Grice, April; Parker, Laurence

2018-01-01

The research presented in this study focuses on Educational Cultural Negotiators (ECNs). The participants were teachers, administrators, and graduate students in an after-school program in the Midwest and a community-based school/university partnership in the Western U.S. We posit that the roles of the ECNs function as advocacy leaders to invoke…

Improved Method for the Incorporation of Heme Cofactors into Recombinant Proteins Using Escherichia coli Nissle 1917.

PubMed

Fiege, Kerstin; Querebillo, Christine Joy; Hildebrandt, Peter; Frankenberg-Dinkel, Nicole

2018-05-15

Recombinant production of heme proteins in Escherichia coli is often limited by the availability of heme in the host. Therefore, several methods, including the reconstitution of heme proteins after production but prior to purification or the HPEX system, conferring the ability to take up external heme have been developed and used in the past. Here we describe the use of the apathogenic E. coli strain Nissle 1917 (EcN) as a suitable host for the recombinant production of heme proteins. EcN has an advantage over commonly used lab strains in that it is able to take up heme from the environment through the heme receptor ChuA. Expression of several heme proteins from different prokaryotic sources led to high yield and quantitative incorporation of the cofactor when heme was supplied in the growth medium. Comparative UV-vis and resonance Raman measurements revealed that the method employed has significant influence on heme coordination with the EcN system representing the most native situation. Therefore, the use of EcN as a host for recombinant heme protein production represents an inexpensive and straightforward method to facilitate further investigations of structure and function.

Exposure control strategies in the carbonaceous nanomaterial industry.

PubMed

Dahm, Matthew M; Yencken, Marianne S; Schubauer-Berigan, Mary K

2011-06-01

Little is known about exposure control strategies currently being implemented to minimize exposures during the production or use of nanomaterials in the United States. Our goal was to estimate types and quantities of materials used and factors related to workplace exposure reductions among companies manufacturing or using engineered carbonaceous nanomaterials (ECNs). Information was collected through phone surveys on work practices and exposure control strategies from 30 participating producers and users of ECN. The participants were classified into three groups for further examination. We report here the use of exposure control strategies. Observed patterns suggest that large-scale manufacturers report greater use of nanospecific exposure control strategies particularly for respiratory protection. Workplaces producing or using ECN generally report using engineering and administrative controls as well as personal protective equipment to control workplace employee exposure.

Use of a Pro-Fibrogenic Mechanisms-Based Predictive Toxicological Approach for Tiered Testing and Decision Analysis of Carbonaceous Nanomaterials

PubMed Central

Wang, Xiang; Duch, Matthew C.; Mansukhani, Nikhita; Ji, Zhaoxia; Liao, Yu-Pei; Wang, Meiying; Zhang, Haiyuan; Sun, Bingbing; Chang, Chong Hyun; Li, Ruibin; Lin, Sijie; Meng, Huan; Xia, Tian; Hersam, Mark C.; Nel, André E.

2015-01-01

Engineered carbonaceous nanomaterials (ECNs), including single-wall carbon nanotubes (SWCNTs), multi-wall carbon nanotubes (MWCNTs), graphene and graphene oxide (GO), are potentially hazardous to the lung. With incremental experience in the use of predictive toxicological approaches, seeking to relate ECN physicochemical properties to adverse outcome pathways (AOPs), it is logical to explore the existence of a common AOP that allows comparative analysis of broad ECN categories. We established an ECN library comprised of three different types of SWCNTs, graphene and graphene oxide (two sizes) for comparative analysis according to a cell-based AOP that also plays a role in the pathogenesis of pulmonary fibrosis. SWCNTs synthesized by Hipco, arc discharge and Co-Mo catalyst (CoMoCAT®) methods were obtained in their as-prepared (AP) state, following which they were further purified (PD) or coated with Pluronic (PF108) or bovine serum albumin (BSA) to improve dispersal and colloidal stability. Graphene oxide (GO) was prepared as two sizes, GO-small (S) and GO-large (L), while the graphene samples were coated with BSA and PF108 to enable dispersion in aqueous solution. In vitro screening showed that AP- and PD-SWCNTs, irrespective of the method of synthesis, as well as graphene (BSA) and GO (S and L) could trigger interleukin 1β (IL-1β) and transforming growth factor (TGF-β1) production in myeloid (THP-1) and epithelial (BEAS-2B) cell lines, respectively. Oropharyngeal aspiration in mice confirmed that AP-Hipco tubes, graphene (BSA), GO-S and GO-L could induce IL-1β and TGF-β1 production in the lung in parallel with lung fibrosis. Notably, GO-L was the most pro-fibrogenic material based on rapid kinetics of pulmonary injury. In contrast, PF108-dispersed SWCNTs and -graphene failed to exert fibrogenic effects. Collectively, these data indicate that the dispersal state and surface reactivity of ECNs play key roles in triggering a pro-fibrogenic AOP, which could prove helpful for hazard ranking and a proposed tiered testing approach for large ECN categories. PMID:25646681

In situ characterization of natural pyrite bioleaching using electrochemical noise technique

NASA Astrophysics Data System (ADS)

Chen, Guo-bao; Yang, Hong-ying; Li, Hai-jun

2016-02-01

An in situ characterization technique called electrochemical noise (ECN) was used to investigate the bioleaching of natural pyrite. ECN experiments were conducted in four active systems (sulfuric acid, ferric-ion, 9k culture medium, and bioleaching solutions). The ECN data were analyzed in both the time and frequency domains. Spectral noise impedance spectra obtained from power spectral density (PSD) plots for different systems were compared. A reaction mechanism was also proposed on the basis of the experimental data analysis. The bioleaching system exhibits the lowest noise resistance of 0.101 MΩ. The bioleaching of natural pyrite is considered to be a bio-battery reaction, which distinguishes it from chemical oxidation reactions in ferric-ion and culture-medium (9k) solutions. The corrosion of pyrite becomes more severe over time after the long-term testing of bioleaching.

Brain Activity and Functional Connectivity Associated with Hypnosis.

PubMed

Jiang, Heidi; White, Matthew P; Greicius, Michael D; Waelde, Lynn C; Spiegel, David

2017-08-01

Hypnosis has proven clinical utility, yet changes in brain activity underlying the hypnotic state have not yet been fully identified. Previous research suggests that hypnosis is associated with decreased default mode network (DMN) activity and that high hypnotizability is associated with greater functional connectivity between the executive control network (ECN) and the salience network (SN). We used functional magnetic resonance imaging to investigate activity and functional connectivity among these three networks in hypnosis. We selected 57 of 545 healthy subjects with very high or low hypnotizability using two hypnotizability scales. All subjects underwent four conditions in the scanner: rest, memory retrieval, and two different hypnosis experiences guided by standard pre-recorded instructions in counterbalanced order. Seeds for the ECN, SN, and DMN were left and right dorsolateral prefrontal cortex, dorsal anterior cingulate cortex (dACC), and posterior cingulate cortex (PCC), respectively. During hypnosis there was reduced activity in the dACC, increased functional connectivity between the dorsolateral prefrontal cortex (DLPFC;ECN) and the insula in the SN, and reduced connectivity between the ECN (DLPFC) and the DMN (PCC). These changes in neural activity underlie the focused attention, enhanced somatic and emotional control, and lack of self-consciousness that characterizes hypnosis. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Stereotactic Radiation Therapy can Safely and Durably Control Sites of Extra-Central Nervous System Oligoprogressive Disease in Anaplastic Lymphoma Kinase-Positive Lung Cancer Patients Receiving Crizotinib

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gan, Gregory N., E-mail: gregory.gan@ucdenver.edu; Weickhardt, Andrew J.; Scheier, Benjamin

Purpose: To analyze the durability and toxicity of radiotherapeutic local ablative therapy (LAT) applied to extra-central nervous system (eCNS) disease progression in anaplastic lymphoma kinase-positive non-small cell lung cancer (NSCLC) patients. Methods and Materials: Anaplastic lymphoma kinase-positive NSCLC patients receiving crizotinib and manifesting ≤4 discrete sites of eCNS progression were classified as having oligoprogressive disease (OPD). If subsequent progression met OPD criteria, additional courses of LAT were considered. Crizotinib was continued until eCNS progression was beyond OPD criteria or otherwise not suitable for further LAT. Results: Of 38 patients, 33 progressed while taking crizotinib. Of these, 14 had eCNS progressionmore » meeting OPD criteria suitable for radiotherapeutic LAT. Patients with eCNS OPD received 1-3 courses of LAT with radiation therapy. The 6- and 12-month actuarial local lesion control rates with radiation therapy were 100% and 86%, respectively. The 12-month local lesion control rate with single-fraction equivalent dose >25 Gy versus ≤25 Gy was 100% versus 60% (P=.01). No acute or late grade >2 radiation therapy-related toxicities were observed. Median overall time taking crizotinib among those treated with LAT versus those who progressed but were not suitable for LAT was 28 versus 10.1 months, respectively. Patients continuing to take crizotinib for >12 months versus ≤12 months had a 2-year overall survival rate of 72% versus 12%, respectively (P<.0001). Conclusions: Local ablative therapy safely and durably eradicated sites of individual lesion progression in anaplastic lymphoma kinase-positive NSCLC patients receiving crizotinib. A dose–response relationship for local lesion control was observed. The suppression of OPD by LAT in patients taking crizotinib allowed an extended duration of exposure to crizotinib, which was associated with longer overall survival.« less

Analysis of electrochemical noise (ECN) data in time and frequency domain for comparison corrosion inhibition of some azole compounds on Cu in 1.0 M H2SO4 solution

NASA Astrophysics Data System (ADS)

Ramezanzadeh, B.; Arman, S. Y.; Mehdipour, M.; Markhali, B. P.

2014-01-01

In this study, the corrosion inhibition properties of two similar heterocyclic compounds namely benzotriazole (BTA) and benzothiazole (BNS) inhibitors on copper in 1.0 M H2SO4 solution were studied by electrochemical techniques as well as surface analysis. The results showed that corrosion inhibition of copper largely depends on the molecular structure and concentration of the inhibitors. The effect of DC trend on the interpretation of electrochemical noise (ECN) results in time domain was evaluated by moving average removal (MAR) method. Accordingly, the impact of square and Hanning window functions as drift removal methods in frequency domain was studied. After DC trend removal, a good trend was observed between electrochemical noise (ECN) data and the results obtained from EIS and potentiodynamic polarization. Furthermore, the shot noise theory in frequency domain was applied to approach the charge of each electrochemical event (q) from the potential and current noise signals.

Genetically engineered Escherichia coli Nissle 1917 synbiotic counters fructose-induced metabolic syndrome and iron deficiency.

PubMed

Chaudhari, Archana Somabhai; Raghuvanshi, Ruma; Kumar, G Naresh

2017-06-01

Consumption of fructose leads to metabolic syndrome, but it is also known to increase iron absorption. Present study investigates the effect of genetically modified Escherichia coli Nissle 1917 (EcN) synbiotic along with fructose on non-heme iron absorption. Charles foster rats weighing 150-200 g were fed with iron-deficient diet for 2 months. Probiotic treatment of EcN (pqq) and EcN (pqq-glf-mtlK) was given once per week, 10 9  cells after 2 months with fructose in drinking water. Iron levels, blood, and liver parameters for oxidative stress, hyperglycemia, and dyslipidemia were estimated. Transferrin-bound iron levels in the blood decreased significantly after 10 weeks of giving iron-deficient diet. Probiotic treatment of EcN (pqq-glf-mtlK) and fructose together led to the restoration of normal transferrin-bound iron levels and blood and hepatic antioxidant levels as compared to iron-deficient control group. The probiotic also led to the restoration of body weight along with levels of serum and hepatic lipid, blood glucose, and antioxidant in the blood and liver as compared to iron-deficient control group. Restoration of liver injury marker enzymes was also seen. Administration of EcN-producing PQQ and mannitol dehydrogenase enzyme together with fructose led to increase in the transferrin-bound iron levels in the blood and amelioration of consequences of metabolic syndrome caused due to fructose consumption.

Brain functional network abnormality extends beyond the sensorimotor network in brachial plexus injury patients.

PubMed

Feng, Jun-Tao; Liu, Han-Qiu; Hua, Xu-Yun; Gu, Yu-Dong; Xu, Jian-Guang; Xu, Wen-Dong

2016-12-01

Brachial plexus injury (BPI) is a type of severe peripheral nerve trauma that leads to central remodeling in the brain, as revealed by functional MRI analysis. However, previously reported remodeling is mostly restricted to sensorimotor areas of the brain. Whether this disturbance in the sensorimotor network leads to larger-scale functional remodeling remains unknown. We sought to explore the higher-level brain functional abnormality pattern of BPI patients from a large-scale network function connectivity dimension in 15 right-handed BPI patients. Resting-state functional MRI data were collected and analyzed using independent component analysis methods. Five components of interest were recognized and compared between patients and healthy subjects. Patients showed significantly altered brain local functional activities in the bilateral fronto-parietal network (FPN), sensorimotor network (SMN), and executive-control network (ECN) compared with healthy subjects. Moreover, functional connectivity between SMN and ECN were significantly less in patients compared with healthy subjects, and connectivity strength between ECN and SMN was negatively correlated with patients' residual function of the affected limb. Functional connectivity between SMN and right FPN were also significantly less than in controls, although connectivity between ECN and default mode network (DMN) was greater than in controls. These data suggested that brain functional disturbance in BPI patients extends beyond the sensorimotor network and cascades serial remodeling in the brain, which significantly correlates with residual hand function of the paralyzed limb. Furthermore, functional remodeling in these higher-level functional networks may lead to cognitive alterations in complex tasks.

Heterogeneity of the environmental regulation of industrial wastewater: European wineries.

PubMed

Román-Sánchez, Isabel M; Aznar-Sánchez, José A; Belmonte-Ureña, Luis J

2015-01-01

The European legislation of the pollution of industrial wastewater shows a high degree of heterogeneity. This fact implies that there is a market failure with relevant consequences. Within the European Union, each Member State performs a specific transposition of the Water Framework Directive 2000/60. The member states introduce different sanitation fees to correct water pollution. In this paper, the case of the European wine industry is analyzed. It studies the sanitation fees of the five major wine producing countries: France, Italy, Spain, Germany and Portugal. Results show significant differences among the wastewater fees and the study reveals how such heterogeneity leads to relevant market distortions. The research concludes that more homogeneous environmental regulation would promote more sustainable wine production processes with more efficient water management and purification systems, as well as the introduction of cutting edge technologies.

Interleukin-8, CXCL1, and MicroRNA miR-146a Responses to Probiotic Escherichia coli Nissle 1917 and Enteropathogenic E. coli in Human Intestinal Epithelial T84 and Monocytic THP-1 Cells after Apical or Basolateral Infection.

PubMed

Sabharwal, Harshana; Cichon, Christoph; Ölschläger, Tobias A; Sonnenborn, Ulrich; Schmidt, M Alexander

2016-09-01

Bacterium-host interactions in the gut proceed via directly contacted epithelial cells, the host's immune system, and a plethora of bacterial factors. Here we characterized and compared exemplary cytokine and microRNA (miRNA) responses of human epithelial and THP-1 cells toward the prototype enteropathogenic Escherichia coli (EPEC) strain E2348/69 (O127:H6) and the probiotic strain Escherichia coli Nissle 1917 (EcN) (O6:K5:H1). Human T84 and THP-1 cells were used as cell culture-based model systems for epithelial and monocytic cells. Polarized T84 monolayers were infected apically or basolaterally. Bacterial challenges from the basolateral side resulted in more pronounced cytokine and miRNA responses than those observed for apical side infections. Interestingly, the probiotic EcN also caused a pronounced transcriptional increase of proinflammatory CXCL1 and interleukin-8 (IL-8) levels when human T84 epithelial cells were infected from the basolateral side. miR-146a, which is known to regulate adaptor molecules in Toll-like receptor (TLR)/NF-κB signaling, was found to be differentially regulated in THP-1 cells between probiotic and pathogenic bacteria. To assess the roles of flagella and flagellin, we employed several flagellin mutants of EcN. EcN flagellin mutants induced reduced IL-8 as well as CXCL1 responses in T84 cells, suggesting that flagellin is an inducer of this cytokine response. Following infection with an EPEC type 3 secretion system (T3SS) mutant, we observed increased IL-8 and CXCL1 transcription in T84 and THP-1 cells compared to that in wild-type EPEC. This study emphasizes the differential induction of miR-146a by pathogenic and probiotic E. coli strains in epithelial and immune cells as well as a loss of probiotic properties in EcN interacting with cells from the basolateral side. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Functional Connectivity with Distinct Neural Networks Tracks Fluctuations in Gain/Loss Framing Susceptibility

PubMed Central

Smith, David V.; Sip, Kamila E.; Delgado, Mauricio R.

2016-01-01

Multiple large-scale neural networks orchestrate a wide range of cognitive processes. For example, interoceptive processes related to self-referential thinking have been linked to the default-mode network (DMN); whereas exteroceptive processes related to cognitive control have been linked to the executive-control network (ECN). Although the DMN and ECN have been postulated to exert opposing effects on cognition, it remains unclear how connectivity with these spatially overlapping networks contribute to fluctuations in behavior. While previous work has suggested the medial prefrontal cortex (MPFC) is involved in behavioral change following feedback, these observations could be linked to interoceptive processes tied to DMN or exteroceptive processes tied to ECN because MPFC is positioned in both networks. To address this problem, we employed independent component analysis combined with dual-regression functional connectivity analysis. Participants made a series of financial decisions framed as monetary gains or losses. In some sessions, participants received feedback from a peer observing their choices; in other sessions, feedback was not provided. Following feedback, framing susceptibility—indexed as the increase in gambling behavior in loss frames compared to gain frames—was heightened in some participants and diminished in others. We examined whether these individual differences were linked to differences in connectivity by contrasting sessions containing feedback against those that did not contain feedback. We found two key results. As framing susceptibility increased, the MPFC increased connectivity with DMN; in contrast, temporal-parietal junction decreased connectivity with the ECN. Our results highlight how functional connectivity patterns with distinct neural networks contribute to idiosyncratic behavioral changes. PMID:25858445

Functional connectivity with distinct neural networks tracks fluctuations in gain/loss framing susceptibility.

PubMed

Smith, David V; Sip, Kamila E; Delgado, Mauricio R

2015-07-01

Multiple large-scale neural networks orchestrate a wide range of cognitive processes. For example, interoceptive processes related to self-referential thinking have been linked to the default-mode network (DMN); whereas exteroceptive processes related to cognitive control have been linked to the executive-control network (ECN). Although the DMN and ECN have been postulated to exert opposing effects on cognition, it remains unclear how connectivity with these spatially overlapping networks contribute to fluctuations in behavior. While previous work has suggested the medial-prefrontal cortex (MPFC) is involved in behavioral change following feedback, these observations could be linked to interoceptive processes tied to DMN or exteroceptive processes tied to ECN because MPFC is positioned in both networks. To address this problem, we employed independent component analysis combined with dual-regression functional connectivity analysis. Participants made a series of financial decisions framed as monetary gains or losses. In some sessions, participants received feedback from a peer observing their choices; in other sessions, feedback was not provided. Following feedback, framing susceptibility-indexed as the increase in gambling behavior in loss frames compared to gain frames-was heightened in some participants and diminished in others. We examined whether these individual differences were linked to differences in connectivity by contrasting sessions containing feedback against those that did not contain feedback. We found two key results. As framing susceptibility increased, the MPFC increased connectivity with DMN; in contrast, temporal-parietal junction decreased connectivity with the ECN. Our results highlight how functional connectivity patterns with distinct neural networks contribute to idiosyncratic behavioral changes. © 2015 Wiley Periodicals, Inc.

Quality of Service for Real-Time Applications Over Next Generation Data Networks

NASA Technical Reports Server (NTRS)

Ivancic, William; Atiquzzaman, Mohammed; Bai, Haowei; Su, Hongjun; Jain, Raj; Duresi, Arjan; Goyal, Mukyl; Bharani, Venkata; Liu, Chunlei; Kota, Sastri

2001-01-01

This project, which started on January 1, 2000, was funded by NASA Glenn Research Center for duration of one year. The deliverables of the project included the following tasks: Study of QoS mapping between the edge and core networks envisioned in the Next Generation networks will provide us with the QoS guarantees that can be obtained from next generation networks. Buffer management techniques to provide strict guarantees to real-time end-to-end applications through preferential treatment to packets belonging to real-time applications. In particular, use of ECN to help reduce the loss on high bandwidth-delay product satellite networks needs to be studied. Effect of Prioritized Packet Discard to increase goodput of the network and reduce the buffering requirements in the ATM switches. Provision of new IP circuit emulation services over Satellite IP backbones using MPLS will be studied. Determine the architecture and requirements for internetworking ATN and the Next Generation Internet for real-time applications.

Functional Connectivity Between Anterior Insula and Key Nodes of Frontoparietal Executive Control and Salience Networks Distinguish Bipolar Depression From Unipolar Depression and Healthy Control Subjects.

PubMed

Ellard, Kristen K; Zimmerman, Jared P; Kaur, Navneet; Van Dijk, Koene R A; Roffman, Joshua L; Nierenberg, Andrew A; Dougherty, Darin D; Deckersbach, Thilo; Camprodon, Joan A

2018-05-01

Patients with bipolar depression are characterized by dysregulation across the full spectrum of mood, differentiating them from patients with unipolar depression. The ability to switch neural resources among the default mode network, salience network, and executive control network (ECN) has been proposed as a key mechanism for adaptive mood regulation. The anterior insula is implicated in the modulation of functional network switching. Differential connectivity between anterior insula and functional networks may provide insights into pathophysiological differences between bipolar and unipolar mood disorders, with implications for diagnosis and treatment. Resting-state functional magnetic resonance imaging data were collected from 98 subjects (35 unipolar, 24 bipolar, and 39 healthy control subjects). Pearson correlations were computed between bilateral insula seed regions and a priori defined target regions from the default mode network, salience network, and ECN. After r-to-z transformation, a one-way multivariate analysis of covariance was conducted to identify significant differences in connectivity between groups. Post hoc pairwise comparisons were conducted and Bonferroni corrections were applied. Receiver-operating characteristics were computed to assess diagnostic sensitivity. Patients with bipolar depression evidenced significantly altered right anterior insula functional connectivity with the inferior parietal lobule of the ECN relative to patients with unipolar depression and control subjects. Right anterior insula-inferior parietal lobule connectivity significantly discriminated patients with bipolar depression. Impaired functional connectivity between the anterior insula and the inferior parietal lobule of the ECN distinguishes patients with bipolar depression from those with unipolar depression and healthy control subjects. This finding highlights a pathophysiological mechanism with potential as a therapeutic target and a clinical biomarker for bipolar disorder, exhibiting reasonable sensitivity and specificity. Copyright © 2018 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Improving Explicit Congestion Notification with the Mark-Front Strategy

NASA Technical Reports Server (NTRS)

Liu, Chunlei; Jain, Raj

2001-01-01

Delivering congestion signals is essential to the performance of networks. Current TCP/IP networks use packet losses to signal congestion. Packet losses not only reduces TCP performance, but also adds large delay. Explicit Congestion Notification (ECN) delivers a faster indication of congestion and has better performance. However, current ECN implementations mark the packet from the tail of the queue. In this paper, we propose the mark-front strategy to send an even faster congestion signal. We show that mark-front strategy reduces buffer size requirement, improves link efficiency and provides better fairness among users. Simulation results that verify our analysis are also presented.

The entrance channel effects on the deexcitation ways of the same compound nucleus at a fixed excitation energy

NASA Astrophysics Data System (ADS)

Anastasi, A.; Mandaglio, G.; Curciarello, F.; Nasirov, A. K.; Fazio, G.; Giardina, G.

2018-05-01

The investigation of various properties of deexcitation of the same 220Th compound nucleus (CN), formed by the different mass (charge) asymmetric 16O+204Pb, 40Ar+180Hf, 82Se+138Ba and 96Zr+124Sn reactions is presented. The effective fission barrier < B fis > value, as a function of the excitation energy {E}CN* , determined for each intermediate excited nucleus reached along the deexcitation cascade of the CN obtained by the four considered reactions is strongly sensitive to the various orbital angular momentum L=ℓℏ distributions of CN formed with the same excitation energy {E}CN* by the various entrance channels. Therefore, the competition between the fission and evaporation of light particles (neutron, proton, and α-particle) processes along the deexcitation cascade of CN is dependent on the orbital angular momentum distribution of CN. In fact, the ratio between the evaporation residue cross sections obtained when also the charged particles are emitted and the ones obtained after neutron emission only for the same CN with a fixed excitation energy {E}CN* is sensitive to the mass (charge) asymmetry of the entrance channel.

2015 Student Affordability Report. The NDUS Edge

ERIC Educational Resources Information Center

North Dakota University System, 2015

2015-01-01

In 2014-15, tuition and mandatory fee rates at the University of North Dakota (UND), North Dakota Sate University (NDSU), Minot State University (MiSU) and the four-year campuses were less than their regional counterparts. The gap differential decreased slightly at UND and NDSU and the four-year campuses, and increased slightly at MiSU. NDUS…

Student Affordability Report. Daring to Be Great: The NDUS Edge

ERIC Educational Resources Information Center

North Dakota University System, 2016

2016-01-01

This 2016 student affordability report looks at the following numerical data for higher education in the state of North Dakota: (1) Tuition, Mandatory Fees, Room & Board; (2) Total Estimated Student Cost; (3) Federal Funding Sources; (4) Net Price; (5) Loan Volume and Indebtedness; and (6) Percent of Students with Aid. In 2015-16, tuition and…

Volatile molecular markers of VOO Thermo-oxidation: Effect of heating processes, macronutrients composition, and olive ripeness on the new emitted aldehydic compounds.

PubMed

Oueslati, Imen; Manaï, Hédia; Madrigal-Martínez, Mónica; Martínez-Cañas, Manuel A; Sánchez-Casas, Jacinto; Zarrouk, Mokhtar; Flamini, Guido

2018-04-01

Heating operation has been applied to Chétoui extra-virgin olive oils (EVOOs) extracted from fruits with several ripening stages (RS). The studied samples, were subjected to microwave and conventional heating. Results showed that heated VOOs after 2.5 h and 7 min of conventional and microwave heating, respectively, gave rise to a drastically decrease of LOX products and allowed the detection of toxic new formed aldehydic volatiles (alkanal: nonanal, alkenals: (Z)-2-heptenal and (E)-2-decenal, and alkadienals: (E.E)-2.4-decadienal), which can be used as markers of VOO degradation. Their abundance in the VOO headspaces depends on their boiling points, the rate of their possible degradation to yield other compounds, on the heating processes and on the rate of macronutrients. The emission rate of the new synthesized volatiles during heating processes was mainly attributed to enzymatic oxidation of some fatty acids. Hexanal, (Z)-2-heptenal, (E)-2-octenal, (E)-2-nonenal, (E,E) and (E,Z)-2,4-decadienal, and (E,E)-2,4-nonadienal, derived from linoleic acid, and heptanol, octanal, nonanal, decanal, (E) and (Z)-2-decenal, (E)-2-undecenal, and (E,E)-2,4-nonadienal, are emitted after degradation of oleic acid. During thermo-oxidation, the ECN 44 (LLO, and OLnO), and the ECN 46 (OLO, and PLO + SLL) compounds decreased, whereas, the ECN 48 (OOO, and PPO), and the ECN 50 (SOO) compounds increased when temperature and heating time increased. The several variations of the studied biochemical compounds depend to the heating processes. Ripening stage of olive fruits can be used as a tool to monitor the emission rate of the aldehydic volatiles, but cannot be used for a chemometric discrimination. Copyright © 2018 Elsevier Ltd. All rights reserved.

Statistical Memristor Modeling and Case Study in Neuromorphic Computing

DTIC Science & Technology

2012-06-01

use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and...Sundareswaran, R. Panda , and D. Pan, “Electrical impact of line-edge roughness on sub-45nm node standard cell,” in Proc. SPIE, vol. 7275, 2009, pp. 727 518–727 518–10. 590 26.3

Multi-temperature state-dependent equivalent circuit discharge model for lithium-sulfur batteries

NASA Astrophysics Data System (ADS)

Propp, Karsten; Marinescu, Monica; Auger, Daniel J.; O'Neill, Laura; Fotouhi, Abbas; Somasundaram, Karthik; Offer, Gregory J.; Minton, Geraint; Longo, Stefano; Wild, Mark; Knap, Vaclav

2016-10-01

Lithium-sulfur (Li-S) batteries are described extensively in the literature, but existing computational models aimed at scientific understanding are too complex for use in applications such as battery management. Computationally simple models are vital for exploitation. This paper proposes a non-linear state-of-charge dependent Li-S equivalent circuit network (ECN) model for a Li-S cell under discharge. Li-S batteries are fundamentally different to Li-ion batteries, and require chemistry-specific models. A new Li-S model is obtained using a 'behavioural' interpretation of the ECN model; as Li-S exhibits a 'steep' open-circuit voltage (OCV) profile at high states-of-charge, identification methods are designed to take into account OCV changes during current pulses. The prediction-error minimization technique is used. The model is parameterized from laboratory experiments using a mixed-size current pulse profile at four temperatures from 10 °C to 50 °C, giving linearized ECN parameters for a range of states-of-charge, currents and temperatures. These are used to create a nonlinear polynomial-based battery model suitable for use in a battery management system. When the model is used to predict the behaviour of a validation data set representing an automotive NEDC driving cycle, the terminal voltage predictions are judged accurate with a root mean square error of 32 mV.

ETF Facility evaporator skid orifice sizing design analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

ELLINGSON, S.D.

1999-08-31

This document releases and records the design analysis for sizing the Orifice plate being installed on the Effluent Treatment Facility (ETF) evaporator skid per Engineering Change Notice (ECN) 651583.

Phosphatidylglycerol molecular species of photosynthetic membranes analyzed by high-performance liquid chromatography: theoretical considerations.

PubMed

Xu, Y; Siegenthaler, P A

1996-02-01

A reversed-phase high-performance liquid chromatography technique was developed to separate, identify, and quantify individual phosphatidylglycerol (PG) molecular species in thylakoid membranes isolated from higher plant leaves. PG was first separated by thin-layer chromatography; then the dinitrobenzoyl derivatives of diacylglycerols produced after phospholipase C hydrolysis of PG were separated by a C18 reversed-phase column and detected at 254 nm. A linear response of the detector was observed in the range of 0.025 to 12 nmol of PG molecular species. It was established that there was an excellent correlation (r = 0.996) between the carbon and double-bond number in the aliphatic residues and the relative retention time of dinitrobenzoyl derivatives. A new equivalent carbon number value (ECN*) which takes into consideration the number of cis-(nc) and trans-(nt) double bonds per molecular species was defined as ECN* = CN - 2nc - nt, where CN is the number of carbon atoms in the aliphatic residues. The logarithm of the retention time increased linearily as a function of ECN* value. However, in this type of correlation, it may happen that two molecular species of PG having distinct relative retention times had the same ECN* value. In this case, the two molecular species can be identified by the linear correlation (r = 1) existing between the reciprocal of the relative retention time and the number of double bonds (0 < or = n < or = 3) in the separate 18:n/delta 3-trans-hexadecenoic acid -16:1(3t)- and 18:n/16:0 molecular species series. The advantages of this method are good separation, cohort elution time, quantitative precision, and predictable retention times of PG molecular species from chloroplast membranes. The method has been used routinely to identify the ten PG molecular species of thylakoid membranes in squash, potato, lettuce, and spinach leaf: 18:3/16:1(3t), 18:3/16:0, 18:2/16:1(3t), 18:2/16:0, 18:1/16:1(3t), 18:1/16:0, 18:0/16:1(3t), 18:0/16:0, 16:0/16:1(3t), and 16:0/16:0.

Differential Contribution of Bilateral Supplementary Motor Area to the Effective Connectivity Networks Induced by Task Conditions Using Dynamic Causal Modeling

PubMed Central

Tao, Zhongping; Zhang, Mu

2014-01-01

Abstract Functional imaging studies have indicated hemispheric asymmetry of activation in bilateral supplementary motor area (SMA) during unimanual motor tasks. However, the hemispherically special roles of bilateral SMAs on primary motor cortex (M1) in the effective connectivity networks (ECN) during lateralized tasks remain unclear. Aiming to study the differential contribution of bilateral SMAs during the motor execution and motor imagery tasks, and the hemispherically asymmetric patterns of ECN among regions involved, the present study used dynamic causal modeling to analyze the functional magnetic resonance imaging data of the unimanual motor execution/imagery tasks in 12 right-handed subjects. Our results demonstrated that distributions of network parameters underlying motor execution and motor imagery were significantly different. The variation was mainly induced by task condition modulations of intrinsic coupling. Particularly, regardless of the performing hand, the task input modulations of intrinsic coupling from the contralateral SMA to contralateral M1 were positive during motor execution, while varied to be negative during motor imagery. The results suggested that the inhibitive modulation suppressed the overt movement during motor imagery. In addition, the left SMA also helped accomplishing left hand tasks through task input modulation of left SMA→right SMA connection, implying that hemispheric recruitment occurred when performing nondominant hand tasks. The results specified differential and altered contributions of bilateral SMAs to the ECN during unimanual motor execution and motor imagery, and highlighted the contributions induced by the task input of motor execution/imagery. PMID:24606178

Altered intra- and inter-network functional coupling of resting-state networks associated with motor dysfunction in stroke.

PubMed

Zhao, Zhiyong; Wu, Jie; Fan, Mingxia; Yin, Dazhi; Tang, Chaozheng; Gong, Jiayu; Xu, Guojun; Gao, Xinjie; Yu, Qiurong; Yang, Hao; Sun, Limin; Jia, Jie

2018-04-24

Motor functions are supported through functional integration across the extended motor system network. Individuals following stroke often show deficits on motor performance requiring coordination of multiple brain networks; however, the assessment of connectivity patterns after stroke was still unclear. This study aimed to investigate the changes in intra- and inter-network functional connectivity (FC) of multiple networks following stroke and further correlate FC with motor performance. Thirty-three left subcortical chronic stroke patients and 34 healthy controls underwent resting-state functional magnetic resonance imaging. Eleven resting-state networks were identified via independent component analysis (ICA). Compared with healthy controls, the stroke group showed abnormal FC within the motor network (MN), visual network (VN), dorsal attention network (DAN), and executive control network (ECN). Additionally, the FC values of the ipsilesional inferior parietal lobule (IPL) within the ECN were negatively correlated with the Fugl-Meyer Assessment (FMA) scores (hand + wrist). With respect to inter-network interactions, the ipsilesional frontoparietal network (FPN) decreased FC with the MN and DAN; the contralesional FPN decreased FC with the ECN, but it increased FC with the default mode network (DMN); and the posterior DMN decreased FC with the VN. In sum, this study demonstrated the coexistence of intra- and inter-network alterations associated with motor-visual attention and high-order cognitive control function in chronic stroke, which might provide insights into brain network plasticity following stroke. © 2018 Wiley Periodicals, Inc.

ECN-23100

NASA Image and Video Library

1983-04-01

An early (1983) photograph of the AFTI F-16 team, commemorating the aircraft's 50th flight. It shows the initial configuration and paint finish of the AFTI F-16, as well as the forward mounted canards and the spin chute.

Performance of the Low-Jitter High-Gain/Bandwidth Front-End Electronics of the HADES tRPC Wall

NASA Astrophysics Data System (ADS)

Belver, Daniel; Cabanelas, P.; Castro, E.; Garzon, J. A.; Gil, A.; Gonzalez-Diaz, D.; Koenig, W.; Traxler, M.

2010-10-01

A front-end electronics (FEE) chain for accurate time measurements has been developed for the new Resistive Plate Chamber (RPC)-based Time-of-Flight (TOF) wall of the High Acceptance Di-Electron Spectrometer (HADES). The wall covers an area of around 8 m2, divided in 6 sectors. In total, 1122 4-gap timing RPC cells are read-out by 2244 time and charge sensitive channels. The FEE chain consists of 2 custom-made boards: a 4-channel DaughterBOard (DBO) and a 32-channel MotherBOard (MBO). The DBO uses a fast 2 GHz amplifier feeding a dual high-speed discriminator. The time and charge information are encoded, respectively, in the leading edge and the width of an LVDS signal. Each MBO houses up to 8 DBOs providing them regulated voltage supply, threshold values via DACs, test signals and, additionally, routing out a signal proportional to the channel multiplicity needed for a 1st level trigger decision. The MBO delivers LVDS signals to a multi-purpose Trigger Readout Board (TRB) for data acquisition. The FEE allows achieving a system resolution around 75 ps fulfilling comfortably the requirements of the HADES upgrade .

Oxidation of SiC

NASA Astrophysics Data System (ADS)

Cooper, James A.

1997-03-01

SiC is a wide band gap hexagonal anisotropic semiconductor which is attractive for use in high voltage, high temperature, or high power applications. SiC is also the only compound semiconductor that can be thermally oxidized to form SiO_2, making it possible to construct many conventional MOS devices in this material. The electrical quality of the SiO_2/SiC interface is far from ideal, however, and considerable research is presently directed to understanding and improving this interface. Electrical characterization of the SiC MOS interface is complicated by the wide band gap, since most interface states are energetically too far removed from the conduction or valence bands to respond to electrical stimulation at room temperature. Moreover, very little information is yet available on the properties of the MOS interface on the 4H polytype of SiC (preferred because of it's higher bulk electron mobility) or on interfaces on crystalline surfaces perpendicular to the basal plane (where an equal number of Si and C atoms are present). Finally, electron mobilities in inversion layers on 4H-SiC reported to date are anomolously low, especially in consideration of the relatively high bulk mobilities in this polytype. In this talk we will discuss MOS characterization techniques for wide band gap semiconductors and review the current understanding of the physics of the MOS interface on thermally oxidized SiC.

Mapping Operation and Maintenance Strategy for U.S. Offshore Wind Farms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dewan, Ashish; Stehly, Tyler

This presentation provides an overview of a collaborative effort between ECN and the National Renewable Energy Laboratory that focused on an operation and maintenance study of six offshore wind power plants in the United States.

ECN-1880

NASA Image and Video Library

1969-01-09

Flight Research Center and Dryden Flight Research Center engineer R. Dale Reed has long used free-flight models to test new concepts. This photo from 1963 shows two different models of the M2-F2 (one under the Mothership) and four Hyper III shapes.

ECN-14284

NASA Image and Video Library

1980-12-30

A close-up view of the Highly Maneuverable Aircraft Technology (HiMAT) research vehicle attached to a wing pylon on NASA’s B-52 mothership during a 1980 test flight. The HiMAT used sharply swept-back wings and a canard configuration to test possible technology for advanced fighters.

Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest

PubMed Central

Tunbridge, Elizabeth M.; Farrell, Sarah M.; Harrison, Paul J.; Mackay, Clare E.

2013-01-01

Catechol-O-methyltransferase (COMT) modulates dopamine in the prefrontal cortex (PFC) and influences PFC dopamine-dependent cognitive task performance. A human COMT polymorphism (Val158Met) alters enzyme activity and is associated with both the activation and functional connectivity of the PFC during task performance, particularly working memory. Here, we used functional magnetic resonance imaging and a data-driven, independent components analysis (ICA) approach to compare resting state functional connectivity within the executive control network (ECN) between young, male COMT Val158 (n = 27) and Met158 (n = 28) homozygotes. COMT genotype effects on grey matter were assessed using voxel-based morphometry. COMT genotype significantly modulated functional connectivity within the ECN, which included the head of the caudate, and anterior cingulate and frontal cortical regions. Val158 homozygotes showed greater functional connectivity between a cluster within the left ventrolateral PFC and the rest of the ECN (using a threshold of Z > 2.3 and a family-wise error cluster significance level of p < 0.05). This difference occurred in the absence of any alterations in grey matter. Our data show that COMT Val158Met affects the functional connectivity of the PFC at rest, complementing its prominent role in the activation and functional connectivity of this region during cognitive task performance. The results suggest that genotype-related differences in prefrontal dopaminergic tone result in neuroadaptive changes in basal functional connectivity, potentially including subtle COMT genotype-dependent differences in the relative coupling of task-positive and task-negative regions, which could in turn contribute to its effects on brain activation, connectivity, and behaviour. PMID:23228511

Disrupted coupling of large-scale networks is associated with relapse behaviour in heroin-dependent men

PubMed Central

Li, Qiang; Liu, Jierong; Wang, Wei; Wang, Yarong; Li, Wei; Chen, Jiajie; Zhu, Jia; Yan, Xuejiao; Li, Yongbin; Li, Zhe; Ye, Jianjun; Wang, Wei

2018-01-01

Background It is unknown whether impaired coupling among 3 core large-scale brain networks (salience [SN], default mode [DMN] and executive control networks [ECN]) is associated with relapse behaviour in treated heroin-dependent patients. Methods We conducted a prospective resting-state functional MRI study comparing the functional connectivity strength among healthy controls and heroin-dependent men who had either relapsed or were in early remission. Men were considered to be either relapsed or in early remission based on urine drug screens during a 3-month follow-up period. We also examined how the coupling of large-scale networks correlated with relapse behaviour among heroin-dependent men. Results We included 20 controls and 50 heroin-dependent men (26 relapsed and 24 early remission) in our analyses. The relapsed men showed greater connectivity than the early remission and control groups between the dorsal anterior cingulate cortex (key node of the SN) and the dorsomedial prefrontal cortex (included in the DMN). The relapsed men and controls showed lower connectivity than the early remission group between the left dorsolateral prefrontal cortex (key node of the left ECN) and the dorsomedial prefrontal cortex. The percentage of positive urine drug screens positively correlated with the coupling between the dorsal anterior cingulate cortex and dorsomedial prefrontal cortex, but negatively correlated with the coupling between the left dorsolateral prefrontal cortex and dorsomedial prefrontal cortex. Limitations We examined deficits in only 3 core networks leading to relapse behaviour. Other networks may also contribute to relapse. Conclusion Greater coupling between the SN and DMN and lower coupling between the left ECN and DMN is associated with relapse behaviour. These findings may shed light on the development of new treatments for heroin addiction. PMID:29252165

Small Supernumerary Marker Chromosome May Provide Information on Dosage-insensitive Pericentric Regions in Human.

PubMed

Al-Rikabi, Ahmed B Hamid; Pekova, Sona; Fan, Xioabo; Jančušková, Tereza; Liehr, Thomas

2018-04-01

Cytogenetically visible chromosomal imbalances in humans are deleterious and adverse in the majority of the cases. However, healthy persons living with chromosomal imbalances in the range of several megabasepairs (Mbps) in size, like carriers of small Supernumerary Marker Chromosomes (sSMCs) exist. The identification of healthy sSMC carriers with euchromatic centromere-near (ECN) imbalances led to the following proposal: ECN-regions do not contain any dosage sensitive genes. Due to own previous work, dosage-insensitive pericentric ECN-regions were already determined with an accuracy of 0.3 and 5 Mbp. Based on this data we established 43 new pericentromeric probe sets spanning about 3-5 Mbp of each euchromatic human chromosome arm starting from the known insensitive regions towards distal. Such so called pericentromeric-critical region fluorescence in situ hybridization (PeCR-FISH) probe sets were applied exemplarily and successful here in 15 sSMC cases as available from the Else Kröner-Fresenius-sSMC-cellbank . Most of the involved sSMC breakpoints could be characterized as a higher resolution than before. An unexpected result was that in 5/15 cases cryptic mosaicism was characterized. The latter is also to be considered to have potentially an influence on the clinical outcome in these so-called discontinuous sSMCs. Overall, the suitability of PeCR-FISH to characterize sSMCs was proven; the potential of this probe set to further delineate sizes of dosage insensitive pericentric regions is obvious but dependent on suited cases. Furthermore, discontinuous sSMCs can be identified by this approach and this new subtype of sSMC needs to be studied in more detail in future.

Distinct inflammatory and cytopathic characteristics of Escherichia coli isolates from inflammatory bowel disease patients.

PubMed

Jensen, Stina Rikke; Mirsepasi-Lauridsen, Hengameh Chloé; Thysen, Anna Hammerich; Brynskov, Jørn; Krogfelt, Karen A; Petersen, Andreas Munk; Pedersen, Anders Elm; Brix, Susanne

2015-12-01

Escherichia coli (E. coli) may be implicated in the pathogenesis of inflammatory bowel disease (IBD), as implied from a higher prevalence of mucosa-associated E. coli in the gut of IBD-affected individuals. However, it is unclear whether different non-diarrheagenic E. coli spp. segregate from each other in their ability to promote intestinal inflammation. Herein we compared the inflammation-inducing properties of non-diarrheagenic LF82, 691-04A, E. coli Nissle 1917 (ECN) and eleven new intestinal isolates from different locations in five IBD patients and one healthy control. Viable E. coli were cultured with human monocyte-derived dendritic cells (moDCs) and monolayers of intestinal epithelial cells (IECs), followed by analysis of secreted cytokines, intracellular levels of reactive oxygen species and cellular death. The IBD-associated E. coli LF82 induced the same dose-dependent inflammatory cytokine profile as ECN and ten of the new E. coli isolates displayed as high level IL-12p70, IL-1β, IL-23 and TNF-α from moDCs irrespective of their site of isolation (ileum/colon/faeces), disease origin (diseased/non-diseased) or known virulence factors. Contrarily, 691-04A and one new IBD E. coli isolate induced a different cellular phenotype with enhanced killing of moDCs and IECs, coupled to elevated IL-18. The cytopathic nature of 691-04A and one other IBD E. coli isolate suggests that colonization with specific non-diarrheagenic E. coli could promote intestinal barrier leakage and profound intestinal inflammation, while LF82, ECN and the remaining non-diarrheagenic E. coli isolates hold notorious pro-inflammatory characteristics that can progress inflammation in case of intestinal barrier leakage. Copyright © 2015 Elsevier GmbH. All rights reserved.

Networked Leadership in Educational Collaborative Networks

ERIC Educational Resources Information Center

Díaz-Gibson, Jordi; Zaragoza, Mireia Civís; Daly, Alan J.; Mayayo, Jordi Longás; Romaní, Jordi Riera

2017-01-01

Educational Collaborative Networks (ECNs) aim to achieve educational goals at the community level and base their actions on collaborative partnering between schools and community organizations. These approaches are an emergent and innovative leadership and policy strategy being used increasingly across the globe, given the interconnected and…

Functional eladic containing triglycerides: Synthesis, physical properties, and solution behavior

USDA-ARS?s Scientific Manuscript database

The enthalpy of fusion (Hf) for a number of symmetrical and asymmetrical triacylgylcerides as mixtures in soybean oil (TAGs) were determined by melting point data (MPD), differential scanning calorimetry (DSC), and effective carbon numbers (ECN). Pure triacylgylcerides were mixed with soybean oil an...

Wind Turbine Wake Experiment - Wieringermeer (WINTWEX-W)

NASA Astrophysics Data System (ADS)

Kumer, V. M.; Reuder, J.; Svardal, B.; Eecen, P.

2014-12-01

WINTWEX-W is a cooperative wake measurement campaign conducted by the Norwegian Centre of Offshore Wind Energy (Norcowe) and the Energy Research Centre of the Netherlands (ECN). A scanning, four static Windcubes as well as a downstream looking nacelle LiDAR were placed for half a year downstream of one of five research wind turbines in ECNs' wind turbine test farm Wieringermeer. In order to capture wake characteristics under different weather conditions we scanned a 60˚ sector at three different elevations and two vertical cross-sections every minute. Windcubes v1 measured wind profiles every second at 2, 5 and 12 rotor diameter downstream distances. Another static Windcube, a forward-looking nacelle LiDAR and three Sonics were placed upstream to measure the undisturbed approaching flow field. The aim of the campaign is a qualitative and quantitative description of single wind turbine wake propagation and persistency, as well as to improve CFD wake models by delivering a detailed data set of several real atmospheric conditions.

Distillation fraction-specific ecotoxicological evaluation of a paraffin-rich crude oil.

PubMed

Erlacher, Elisabeth; Loibner, Andreas P; Kendler, Romana; Scherr, Kerstin E

2013-03-01

Crude oil is a complex mixture of petroleum hydrocarbons (PHC) with distinct chemical, physical and toxicological properties relevant for contaminated site risk assessment. Ecotoxicological effects of crude oil distillation fractions on luminescent bacteria (Vibrio fischeri), earthworms (Dendrobaena hortensis) and invertebrates (Heterocypris incongruens) were tested using two spiked soils and their elutriates. Fraction 2 (F2) had an equivalent carbon number (ECN) range of >10 to 16, and F3 from >16 to 39. F2 showed a substantially higher ecotoxicological effect than F3 for Vibrio and Dendrobaena. In contrast, severe inhibition of Heterocypris by the poorly soluble F3 is attributed to mechanical organ blockage. Immediate sequestration of PHC to the organic matter-rich soil effected reduced toxicity for all organisms. This study indicates that a more differentiated consideration (i) of PHC mixtures based on ECN range and (ii) of model soil properties employed for ecotoxicity testing should be included into PHC-contaminated site risk assessment. Copyright © 2012 Elsevier Ltd. All rights reserved.

ECN-14280

NASA Image and Video Library

1980-12-30

The HiMAT (Highly Maneuverable Aircraft Technology) subscale research vehicle, seen here during a research flight, was flown by the NASA Dryden Flight Research Center, Edwards, California, from mid 1979 to January 1983. The aircraft demonstrated advanced fighter technologies that have been used in the development of many modern high performance military aircraft.

ECN-14273

NASA Image and Video Library

1980-12-30

The HiMAT (Highly Maneuverable Aircraft Technology) subscale research vehicle, seen here during a research flight, was flown by the NASA Dryden Flight Research Center, Edwards, California, from mid 1979 to January 1983. The aircraft demonstrated advanced fighter technologies that have been used in the development of many modern high performance military aircraft.

Quality of Service for Real-Time Applications Over Next Generation Data Networks

NASA Technical Reports Server (NTRS)

Atiquzzaman, Mohammed; Jain, Raj

2001-01-01

This project, which started on January 1, 2000, was funded by the NASA Glenn Research Center for duration of one year. The deliverables of the project included the following tasks: (1) Study of QoS mapping between the edge and core networks envisioned in the Next Generation networks will provide us with the QoS guarantees that can be obtained from next generation networks; (2) Buffer management techniques to provide strict guarantees to real-time end-to-end applications through preferential treatment to packets belonging to real-time applications. In particular, use of ECN to help reduce the loss on high bandwidth-delay product satellite networks needs to be studied; (3) Effect of Prioritized Packet Discard to increase goodput of the network and reduce the buffering requirements in the ATM switches; (4) Provision of new IP circuit emulation services over Satellite IP backbones using MPLS will be studied; and (5) Determine the architecture and requirements for internetworking ATN and the Next Generation Internet for real-time applications. The project has been completed on time. All the objectives and deliverables of the project have been completed. Research results obtained from this project have been published in a number of papers in journals, conferences, and technical reports, included in this document.

Characteristics of Resting-State Functional Connectivity in Intractable Unilateral Temporal Lobe Epilepsy Patients with Impaired Executive Control Function

PubMed Central

Zhang, Chao; Yang, Hongyu; Qin, Wen; Liu, Chang; Qi, Zhigang; Chen, Nan; Li, Kuncheng

2017-01-01

Executive control function (ECF) deficit is a common complication of temporal lobe epilepsy (TLE). Characteristics of brain network connectivity in TLE with ECF dysfunction are still unknown. The aim of this study was to investigate resting-state functional connectivity (FC) changes in patients with unilateral intractable TLE with impaired ECF. Forty right-handed patients with left TLE confirmed by comprehensive preoperative evaluation and postoperative pathological findings were enrolled. The patients were divided into normal ECF (G1) and decreased ECF (G2) groups according to whether they showed ECF impairment on the Wisconsin Card Sorting Test (WCST). Twenty-three healthy volunteers were recruited as the healthy control (HC) group. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI). Group-information-guided independent component analysis (GIG-ICA) was performed to estimate resting-state networks (RSNs) for all subjects. General linear model (GLM) was employed to analyze intra-network FC (p < 0.05, false discovery rate, FDR correction) and inter-network FC (p < 0.05, Bonferroni correction) of RSN among three groups. Pearson correlations between FC and neuropsychological tests were also determined through partial correlation analysis (p < 0.05). Eleven meaningful RSNs were identified from 40 left TLE and 23 HC subjects. Comparison of intra-network FC of all 11 meaningful RSNs did not reveal significant difference among the three groups (p > 0.05, FDR correction). For inter-network analysis, G2 exhibited decreased FC between the executive control network (ECN) and default-mode network (DMN) when compared with G1 (p = 0.000, Bonferroni correction) and HC (p = 0.000, Bonferroni correction). G1 showed no significant difference of FC between ECN and DMN when compared with HC. Furthermore, FC between ECN and DMN had significant negative correlation with perseverative responses (RP), response errors (RE) and perseverative errors (RPE) and had significant positive correlation categories completed (CC) in both G1 and G2 (p < 0.05). No significant difference of Montreal Cognitive Assessment (MoCA) was found between G1 and G2, while intelligence quotient (IQ) testing showed significant difference between G1and G2.There was no correlation between FC and either MoCA or IQ performance. Our findings suggest that ECF impairment in unilateral TLE is not confined to the diseased temporal lobe. Decreased FC between DMN and ECN may be an important characteristic of RSN in intractable unilateral TLE. PMID:29375338

75 FR 44830 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-29

...-dealers and aggregators such as electronic communications networks. A member firm is able to select any... (`ATSs') and electronic communications networks (`ECNs') that the Commission has also nurtured and... the following methods: Electronic Comments Use the Commission's Internet comment form ( http://www.sec...

75 FR 3593 - Concept Release on Equity Market Structure

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-21

..., market data linkages, and undisplayed, or ``dark,'' liquidity. The Commission intends to use the public's... Centers 1. Registered Exchanges 2. ECNs 3. Dark Pools 4. Broker-Dealer Internalization B. Linkages 1... Handling Rules Release''). \\3\\ See, e.g., In the Matter of National Association of Securities Dealers, Inc...

75 FR 69717 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-15

... new Nasdaq product offerings, pending the resolution to this matter. Thus, offering a Managed Data... trading systems (``ATSs''), including dark pools and electronic communication networks (``ECNs''). Each.... A proliferation of dark pools and other ATSs operate profitably with fragmentary shares of...

78 FR 3058 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-15

... Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule... Mode provides ECNs with advertising through attributed quotations which facilitates an increasing rate... comments on the proposed rule change. III. Date of Effectiveness of the Proposed Rule Change and Timing for...

75 FR 55385 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-10

...-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule... guarantee limits the increase in a Members' execution costs associating with failing to meet the volume thresholds of other exchanges and ECNs while a Member is in the process of migrating volumes from one...

Systems Engineering 2010 Workshop | Wind | NREL

Science.gov Websites

turbine aeroelastic model, inflow turbulence model, wind plan layout and interactions, resource model, O on the approach to wind turbine design, choice, and deployment 2:40 Break Computer Science perspective) International Laboratories 3:20 Bernard Bulder, ECN Integral Wind Turbine Design with Focus-6 3

77 FR 2331 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-17

... trading systems (``ATSs''), including dark pools and electronic communication networks (``ECNs''). Each... data at no charge on its Web site in order to attract more order flow, and it uses market data revenue... users.\\19\\ A proliferation of dark pools and other [[Page 2335

78 FR 3940 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-17

... Report regarding a Nasdaq security through the NasdaqTrader.com Web site shall be determined in... improvement of web functionality and the inclusion of supplementary equity information, but has not increased... dark pools and electronic communication networks (``ECNs''). Each SRO market competes to produce...

The Administration of Escherichia coli Nissle 1917 Ameliorates Development of DSS-Induced Colitis in Mice

PubMed Central

Rodríguez-Nogales, Alba; Algieri, Francesca; Garrido-Mesa, José; Vezza, Teresa; Utrilla, Maria P.; Chueca, Natalia; Fernández-Caballero, Jose A.; García, Federico; Rodríguez-Cabezas, Maria E.; Gálvez, Julio

2018-01-01

The beneficial effects of probiotics on immune-based pathologies such as inflammatory bowel disease (IBD) have been well reported. However, their exact mechanisms have not been fully elucidated. Few studies have focused on the impact of probiotics on the composition of the colonic microbiota. The aim of the present study was to correlate the intestinal anti-inflammatory activity of the probiotic Escherichia coli Nissle 1917 (EcN) in the dextran sodium sulfate (DSS) model of mouse colitis with the changes induced in colonic microbiota populations. EcN prevented the DSS-induced colonic damage, as evidenced by lower disease activity index (DAI) values and colonic weight/length ratio, when compared with untreated control mice. The beneficial effects were confirmed biochemically, since the probiotic treatment improved the colonic expression of different cytokines and proteins involved in epithelial integrity. In addition, it restored the expression of different micro-RNAs (miR-143, miR-150, miR-155, miR-223, and miR-375) involved in the inflammatory response that occurs in colitic mice. Finally, the characterization of the colonic microbiota by pyrosequencing showed that the probiotic administration was able to counteract the dysbiosis associated with the intestinal inflammatory process. This effect was evidenced by an increase in bacterial diversity in comparison with untreated colitic mice. The intestinal anti-inflammatory effects of the probiotic EcN were associated with an amelioration of the altered gut microbiome in mouse experimental colitis, especially when considering bacterial diversity, which is reduced in these intestinal conditions. Moreover, this probiotic has shown an ability to modulate expression levels of miRNAs and different mediators of the immune response involved in gut inflammation. This modulation could also be of great interest to understand the mechanism of action of this probiotic in the treatment of IBD.

78 FR 78451 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-26

..., written notice to FINRA Market Operations of its intention to withdraw as a Registered Reporting ADF ECN... rejection by the ADF Trading Center. As such, an incoming order that fully posts to the book of that ADF... book of that ADF Trading Center, and is subsequently cancelled, corrected, etc., the order reporting...

78 FR 51775 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

... change is available on the Exchange's Web site at www.nyse.com , at the principal office of the Exchange... (``ATSs''), including dark pools and electronic communication networks (``ECNs''). Competition among... at no charge on their Web sites in order to attract more order flow, and use revenue rebates from...

Performances of the Front-End Electronics for the HADES RPC TOF wall on a 12C beam

NASA Astrophysics Data System (ADS)

Belver, D.; Cabanelas, P.; Castro, E.; Díaz, J.; Garzón, J. A.; Gil, A.; Gonzalez-Diaz, D.; Koenig, W.; Traxler, M.; Zapata, M.

2009-05-01

A Front-End Electronics (FEE) chain for timing accurate measurements has been developed for the RPC wall upgrade of the High-Acceptance DiElectron Spectrometer (HADES). The wall will cover an area of around 8 m with 1122 RPC cells (2244 electronic channels). The FEE chain consists of two boards: a four-channel DaughterBOard (DBO) and a 32-channel MotherBOard (MBO). The DBO uses a fast 2 GHz amplifier feeding a discriminator. The time and the charge information are encoded in the leading and the trailing edge (by a charge to width method) of an LVDS signal. Each MBO houses up to eight DBOs providing them regulated voltage supply, threshold values via DACs, test signals and collection of their trigger outputs. The MBO delivers LVDS signals to a time-to-digital converter readout board (TRB) based on HPTDC for data acquisition. In this work, we present the performance of the FEE measured using: (a) narrow electronic test pulses and (b) real signals read out in a fully instrumented RPC sextant installed in its final position at the HADES. The detector was exposed to particles coming from reactions of a 12C beam on Be and Nb targets at 2 GeV/A kinetic energy. Results for the whole electronic chain (DBO+MBO+TRB) show a timing jitter of around 40 ps/channel for pulses above 100 fC and 80 ps/channel for beam data taken with the RPC.

78 FR 46652 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-01

... ADF Market Maker or Registered Reporting ADF ECN that is a ``Trading Center,'' as defined in Rule 600... requirements currently in Rule 6271(b). Members who are Trading Centers, as defined in Rule 600(b)(78) of SEC... timetable as agreed to by the member and FINRA. The proposed rule change defines the ``ADF Deposit Amount...

ECN-15655

NASA Image and Video Library

1981-05-21

In this photograph, the C-140 JetStar is fitted with a model of a high-speed propeller. Three different designs were tested at NASA's Dryden Flight Research Facility in 1981-1982. Their swept-back blades were intended to increase the speed and fuel efficiency of turboprop aircraft. Speeds of Mach 0.8 were thought possible, while using 20 to 30 percent less fuel than standard jet engines.

78 FR 51781 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

... proposed rule change is available on the Exchange's Web site at www.nyse.com , at the principal office of... dark pools and electronic communication networks (``ECNs''). Competition among trading platforms can be... provide certain market data at no charge on their Web sites in order to attract more order flow, and use...

Nonlinear Dynamics of Formation of Drops of Non-Newtonian Liquids from Capillaries: Satellite Formation and Flow Transitions

NASA Astrophysics Data System (ADS)

Yildirim, Ozgur E.; Basaran, Osman A.

1999-11-01

Drop formation from capillaries, and the often undesired phenomenon of satellite generation, play a central role in diverse applications including ink-jet printing, biochip processors, and spray coating, where the working fluid is usually non-Newtonian. Although some work has been done in related areas, the phenomenon of formation of drops of non--Newtonian fluids from capillaries has remained largely unexplored. Here a theoretical approach is adopted to study the dripping of axisymmetric drops of non--Newtonian liquids from capillaries. The constitutive equation used accounts for both shear thinning and strain hardening. First, regular perturbation theory is utilized to reduce the spatial dimension of the governing equations to one. The computations rely on Galerkin/finite element analysis with adaptive finite differencing for time integration. The dynamics are followed beyond the first breakup to investigate conditions for occurrence of satellites. Effect of increasing flow rate is also studied to uncover transitions that occur as one moves from a regime of periodic drop formation to one of jetting.

Dysfunctional default mode network and executive control network in people with Internet gaming disorder: Independent component analysis under a probability discounting task.

PubMed

Wang, L; Wu, L; Lin, X; Zhang, Y; Zhou, H; Du, X; Dong, G

2016-04-01

The present study identified the neural mechanism of risky decision-making in Internet gaming disorder (IGD) under a probability discounting task. Independent component analysis was used on the functional magnetic resonance imaging data from 19 IGD subjects (22.2 ± 3.08 years) and 21 healthy controls (HC, 22.8 ± 3.5 years). For the behavioral results, IGD subjects prefer the risky to the fixed options and showed shorter reaction time compared to HC. For the imaging results, the IGD subjects showed higher task-related activity in default mode network (DMN) and less engagement in the executive control network (ECN) than HC when making the risky decisions. Also, we found the activities of DMN correlate negatively with the reaction time and the ECN correlate positively with the probability discounting rates. The results suggest that people with IGD show altered modulation in DMN and deficit in executive control function, which might be the reason for why the IGD subjects continue to play online games despite the potential negative consequences. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Project W-314 acceptance test report HNF-4643 for HNF-4642 241-AN-A valve pit manifold valves and position indication for project W-314

DOE Office of Scientific and Technical Information (OSTI.GOV)

HAMMERS, J.S.

1999-09-22

The purpose of the test was to verify that the AN Tank Farm Manifold Valves can be manually manipulated to the required operating position and that the electrical and visual indications accurately reflect that position. Physical locking devices were also verified to function. The Acceptance Test Procedure HNF-4642, 241-AN-A Valve Pit Manifold Valves and Position Indication was conducted between 23 June and 10 August 1999 at the 200E AN Tank Farm. The test has no open test exceptions. The test was conducted prior to final engineering ''as built'' activities being completed, this had an impact on the procedure and testmore » results, ECN 653752 was written to correct the mismatch between the procedure and actual field conditions. P&ID H-14-100941 was changed via ECN-W-314-4C-120. All components, identified in the procedure, were not found to be labeled and identified as written in the procedure, temporary tags were used for operational identification. A retest of valve ANA-WT-V 318 was required because it was removed from its installed position and modified after testing was completed.« less

ECN-15662

NASA Image and Video Library

1981-05-21

The Dryden C-140 JetStar during testing of advanced propfan designs. Dryden conducted flight research in 1981-1982 on several designs. The technology was developed under the direction of the Lewis Research Center (today the Glenn Research Center, Cleveland, OH) under the Advanced Turboprop Program. Under that program, Langley Research Center in Virginia oversaw work on accoustics and noise reduction. These efforts were intended to develop a high-speed and fuel-efficient turboprop system.

ECN-14283

NASA Image and Video Library

1980-12-30

The Highly Maneuverable Aircraft Technology (HiMAT) research vehicle is shown here mated to a wing pylon on NASA’s B-52 mothership aircraft. The HiMAT was a technology demonstrator to test structures and configurations for advanced fighter concepts. Over the course of more than 40 years, the B-52 proved a valuable workhorse for NASA’s Dryden Flight Research Center (under various names), launching a wide variety of vehicles and conducting numerous other research flights.

Cognitive benefit and cost of acute stress is differentially modulated by individual brain state

PubMed Central

Hermans, Erno J.; Fernández, Guillén

2017-01-01

Abstract Acute stress is associated with beneficial as well as detrimental effects on cognition in different individuals. However, it is not yet known how stress can have such opposing effects. Stroop-like tasks typically show this dissociation: stress diminishes speed, but improves accuracy. We investigated accuracy and speed during a stroop-like task of 120 healthy male subjects after an experimental stress induction or control condition in a randomized, counter-balanced cross-over design; we assessed brain–behavior associations and determined the influence of individual brain connectivity patterns on these associations, which may moderate the effect and help identify stress resilience factors. In the mean, stress was associated to increase in accuracy, but decrease in speed. Accuracy was associated to brain activation in a distributed set of brain regions overlapping with the executive control network (ECN) and speed to temporo-parietal activation. In line with a stress-related large-scale network reconfiguration, individuals showing an upregulation of the salience and down-regulation of the executive-control network under stress displayed increased speed, but decreased performance. In contrast, individuals who upregulate their ECN under stress show improved performance. Our results indicate that the individual large-scale brain network balance under acute stress moderates cognitive consequences of threat. PMID:28402480

Cognitive benefit and cost of acute stress is differentially modulated by individual brain state.

PubMed

Kohn, Nils; Hermans, Erno J; Fernández, Guillén

2017-07-01

Acute stress is associated with beneficial as well as detrimental effects on cognition in different individuals. However, it is not yet known how stress can have such opposing effects. Stroop-like tasks typically show this dissociation: stress diminishes speed, but improves accuracy. We investigated accuracy and speed during a stroop-like task of 120 healthy male subjects after an experimental stress induction or control condition in a randomized, counter-balanced cross-over design; we assessed brain-behavior associations and determined the influence of individual brain connectivity patterns on these associations, which may moderate the effect and help identify stress resilience factors. In the mean, stress was associated to increase in accuracy, but decrease in speed. Accuracy was associated to brain activation in a distributed set of brain regions overlapping with the executive control network (ECN) and speed to temporo-parietal activation. In line with a stress-related large-scale network reconfiguration, individuals showing an upregulation of the salience and down-regulation of the executive-control network under stress displayed increased speed, but decreased performance. In contrast, individuals who upregulate their ECN under stress show improved performance. Our results indicate that the individual large-scale brain network balance under acute stress moderates cognitive consequences of threat. © The Author (2017). Published by Oxford University Press.

Is Rest Really Rest? Resting State Functional Connectivity during Rest and Motor Task Paradigms.

PubMed

Jurkiewicz, Michael T; Crawley, Adrian P; Mikulis, David J

2018-04-18

Numerous studies have identified the default mode network (DMN) within the brain of healthy individuals, which has been attributed to the ongoing mental activity of the brain during the wakeful resting-state. While engaged during specific resting-state fMRI paradigms, it remains unclear as to whether traditional block-design simple movement fMRI experiments significantly influence the default mode network or other areas. Using blood-oxygen level dependent (BOLD) fMRI we characterized the pattern of functional connectivity in healthy subjects during a resting-state paradigm and compared this to the same resting-state analysis performed on motor task data residual time courses after regressing out the task paradigm. Using seed-voxel analysis to define the DMN, the executive control network (ECN), and sensorimotor, auditory and visual networks, the resting-state analysis of the residual time courses demonstrated reduced functional connectivity in the motor network and reduced connectivity between the insula and the ECN compared to the standard resting-state datasets. Overall, performance of simple self-directed motor tasks does little to change the resting-state functional connectivity across the brain, especially in non-motor areas. This would suggest that previously acquired fMRI studies incorporating simple block-design motor tasks could be mined retrospectively for assessment of the resting-state connectivity.

Frame Transmission Efficiency-Based Cross-Layer Congestion Notification Scheme in Wireless Ad Hoc Networks.

PubMed

He, Huaguang; Li, Taoshen; Feng, Luting; Ye, Jin

2017-07-15

Different from the traditional wired network, the fundamental cause of transmission congestion in wireless ad hoc networks is medium contention. How to utilize the congestion state from the MAC (Media Access Control) layer to adjust the transmission rate is core work for transport protocol design. However, recent works have shown that the existing cross-layer congestion detection solutions are too complex to be deployed or not able to characterize the congestion accurately. We first propose a new congestion metric called frame transmission efficiency (i.e., the ratio of successful transmission delay to the frame service delay), which describes the medium contention in a fast and accurate manner. We further present the design and implementation of RECN (ECN and the ratio of successful transmission delay to the frame service delay in the MAC layer, namely, the frame transmission efficiency), a general supporting scheme that adjusts the transport sending rate through a standard ECN (Explicit Congestion Notification) signaling method. Our method can be deployed on commodity switches with small firmware updates, while making no modification on end hosts. We integrate RECN transparently (i.e., without modification) with TCP on NS2 simulation. The experimental results show that RECN remarkably improves network goodput across multiple concurrent TCP flows.

43 CFR 3830.20 - Payment of service charges, location fees, initial maintenance fees, annual maintenance fees and...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Payment of service charges, location fees, initial maintenance fees, annual maintenance fees and oil shale fees. 3830.20 Section 3830.20 Public Lands..., initial maintenance fees, annual maintenance fees and oil shale fees. ...

43 CFR 3830.20 - Payment of service charges, location fees, initial maintenance fees, annual maintenance fees and...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Payment of service charges, location fees, initial maintenance fees, annual maintenance fees and oil shale fees. 3830.20 Section 3830.20 Public Lands..., initial maintenance fees, annual maintenance fees and oil shale fees. ...

43 CFR 3830.20 - Payment of service charges, location fees, initial maintenance fees, annual maintenance fees and...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Payment of service charges, location fees, initial maintenance fees, annual maintenance fees and oil shale fees. 3830.20 Section 3830.20 Public Lands..., initial maintenance fees, annual maintenance fees and oil shale fees. ...

43 CFR 3830.20 - Payment of service charges, location fees, initial maintenance fees, annual maintenance fees and...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Payment of service charges, location fees, initial maintenance fees, annual maintenance fees and oil shale fees. 3830.20 Section 3830.20 Public Lands..., initial maintenance fees, annual maintenance fees and oil shale fees. ...

ECN-1289

NASA Image and Video Library

1966-05-27

The HL-10, seen here parked on the ramp at NASA's Flight Research Center in 1966, had a radically different shape from that of the M2-F2/F3. While the M2s were flat on top and had rounded undersides (giving them a bathtub shape), the HL-10 had a flat lower surface and a rounded top. Both shapes provided lift without wings, however. This photo was taken before the HL-10's fins were modified.

Defense Logistics Agency Computer-Aided Acquisition and Logistics Support Security Measures

DTIC Science & Technology

1989-09-29

sopisit ftre a nduate eiromensweaonsyte dt i vaiou mdi, nfrrngcls- having security features commensurate with today’s weapon system data in various media ...sections, ministrator that has completed an accredited three areas of improvement in security emphasis are APscrt orebfr htst a ecn deemed appropriate...May 1989, been in a hardcopy media and in accordance with Washington, D.C. specific contract clauses and FAR/DFAR. Through CALS, the Government shall

37 CFR 1.311 - Notice of allowance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... fee, in which case the issue fee and publication fee (§ 1.211(e)) must both be paid within three... notice of allowance will operate as a request to charge the correct issue fee or any publication fee due... incorrect issue fee or publication fee; or (2) A fee transmittal form (or letter) for payment of issue fee...

EDITORIAL: Instrumentation and Methods for Neutron Scattering—papers from the 4th European Conference on Neutron Scattering in Lund, Sweden, June 2007

NASA Astrophysics Data System (ADS)

Rennie, Adrian R.

2008-03-01

Neutron scattering is used as a tool to study problems in disciplines that include chemistry, materials science, biology and condensed matter physics as well as problems from neighbouring disciplines such as geology, environmental sciences and archaeology. Equipment for these studies is found at laboratories with research reactors or spallation neutron sources and there are many recent or current developments with new instruments and even entirely new facilities such as the Spallation Neutron Source at Oak Ridge, USA, the OPAL reactor at Lucas Heights, Australia and the second target station at the ISIS facility in the UK. Design and optimization of the instruments at these facilities involves work with many research laboratories and groups in universities. Every four years the European Conference on Neutron Scattering (ECNS) brings together both the specialists in neutron instrumentation and the community of users (in intervening years there are International and American conferences). In June 2007 about 700 delegates came to the 4th ECNS that was held in Lund, Sweden. There were more than 600 presentations as talks and posters. The opportunity to publish papers in Measurement Science and Technology that relate to neutron scattering instrumentation and method development was offered to the participants, and the papers that follow describe some of the recent activity in this field. Accounts of work on condensed matter science and the applications of neutron scattering appear separately in Journal of Physics: Condensed Matter. There are, of course, many features of neutron instrumentation that are specific to this particular field of measurement. However, there are also many elements of apparatus and experiment design that can usefully be shared with a broader community. It is hoped that this issue with papers from ECNS will find a broad community of interest. Apart from descriptions of overall design of diffractometers and spectrometers there are accounts of new components such as detectors, polarizers, focusing devices and sample environments. The organizers and participants are extremely grateful to numerous sponsors that helped to make the conference a great success. An equal debt of gratitude is due to the Institute of Physics and the editorial and publishing staff for agreeing to publish these papers and organizing the refereeing and editorial process efficiently and promptly in a friendly way.

17 CFR 40.6 - Self-certification of rules.

Code of Federal Regulations, 2014 CFR

2014-04-01

... or fee changes, other than fees or fee changes associated with market making or trading incentive...) Fees. Fees or fee changes, other than fees or fee changes associated with market making or trading... amendment of a designated contract market that materially changes a term or condition of a contract for...

17 CFR 40.6 - Self-certification of rules.

Code of Federal Regulations, 2013 CFR

2013-04-01

... or fee changes, other than fees or fee changes associated with market making or trading incentive...) Fees. Fees or fee changes, other than fees or fee changes associated with market making or trading... amendment of a designated contract market that materially changes a term or condition of a contract for...

17 CFR 40.6 - Self-certification of rules.

Code of Federal Regulations, 2012 CFR

2012-04-01

... or fee changes, other than fees or fee changes associated with market making or trading incentive...) Fees. Fees or fee changes, other than fees or fee changes associated with market making or trading... amendment of a designated contract market that materially changes a term or condition of a contract for...

19 CFR 111.96 - Fees.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Monetary Penalty and Payment of Fees § 111.96 Fees. (a) License fee; examination fee; fingerprint fee. Each... submits an application for a license must also pay a fingerprint check and processing fee; the port... fingerprint checks and the Customs fingerprint processing fee, the total of which must be paid to Customs...

19 CFR 111.96 - Fees.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Monetary Penalty and Payment of Fees § 111.96 Fees. (a) License fee; examination fee; fingerprint fee. Each... submits an application for a license must also pay a fingerprint check and processing fee; the port... fingerprint checks and the Customs fingerprint processing fee, the total of which must be paid to Customs...

19 CFR 111.96 - Fees.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Monetary Penalty and Payment of Fees § 111.96 Fees. (a) License fee; examination fee; fingerprint fee. Each... submits an application for a license must also pay a fingerprint check and processing fee; the port... fingerprint checks and the Customs fingerprint processing fee, the total of which must be paid to Customs...

19 CFR 111.96 - Fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Monetary Penalty and Payment of Fees § 111.96 Fees. (a) License fee; examination fee; fingerprint fee. Each... submits an application for a license must also pay a fingerprint check and processing fee; the port... fingerprint checks and the Customs fingerprint processing fee, the total of which must be paid to Customs...

19 CFR 111.96 - Fees.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Monetary Penalty and Payment of Fees § 111.96 Fees. (a) License fee; examination fee; fingerprint fee. Each... submits an application for a license must also pay a fingerprint check and processing fee; the port... fingerprint checks and the Customs fingerprint processing fee, the total of which must be paid to Customs...

A Study of Styrene-Butadiene Rubber Blends as Improved Flame Agents

DTIC Science & Technology

1976-06-01

results of air gun tests. Thus, both elasticity and viscosity must be considered when DD I JAN 7 1473 EDITION OF I NOV 63 IS OBSOLETE UNCLASSIFIED sECURITy...L.EGEND!~ 23.9’ C 0~ 1:? 100 >.80 I.. 20 ini Sha at)sc Fiue2. Prcn eoyof2-ecnSR4/0a Vaiu aisa 38 227 I LI I : hi Ilii Al 01 100 130 6n0 40- Shear Rate

ECN-2478

NASA Image and Video Library

1970-08-09

The C-140 JetStar was reconfigured as the General Purpose Airborne Simulator (GPAS) to simulate the flight characteristics of other aircraft. The JetStar was used for research for supersonic transports, general aviation aircraft, and as a training support aircraft for the Space Shuttle Approach and Landing tests at Dryden Flight Research Center (under different names) at Edwards, CA, in 1977. One of the engineers on the GPAS program was Ken Szalai, who later became Dryden's director from 1990 to August 1998.

Numerical Simulations of Evaporating Sprays in High Pressure and Temperature Operating Conditions (Engine Combustion Network [ECN])

DTIC Science & Technology

2014-05-01

temperature effect in nonreacting and reacting diesel sprays using a novel injector , and imaging diagnostics for liquid phase penetration, light-off...ambient conditions. A single hole, modern common rail injector with an injector diameter of 90 µ (Bosch CRIN 2.4) is used at typical diesel injection... diesel engine operating conditions. The objective of this report is to demonstrate the modeling capability of a recently adopted 3D-Computational Fluid

Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients

PubMed Central

Cavaliere, Carlo; Aiello, Marco; Di Perri, Carol; Amico, Enrico; Martial, Charlotte; Thibaut, Aurore; Laureys, Steven; Soddu, Andrea

2016-01-01

Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. Although the rising evidences about its possible role in the treatment of many neurological and psychiatric conditions exist, no evidences exist about brain functional connectivity substrates underlying tDCS response. We retrospectively evaluated resting state functional Magnetic Resonance Imaging (fMRI) of 16 sub-acute and chronic MCS patients (6 tDCS responders) who successively received a single left dorsolateral prefrontal cortex (DLPFC) tDCS in a double-blind randomized cross-over trial. A seed-based approach for regions of left extrinsic control network (ECN) and default-mode network (DMN) was performed. tDCS responders showed an increased left intra-network connectivity for regions co-activated with left DLPFC, and significantly with left inferior frontal gyrus. Non-responders (NR) MCS patients showed an increased connectivity between left DLPFC and midline cortical structures, including anterior cingulate cortex and precuneus. Our findings suggest that a prior high connectivity with regions belonging to ECN can facilitate transitory recovery of consciousness in a subgroup of MCS patients that underwent tDCS treatment. Therefore, resting state-fMRI could be very valuable in detecting the neuronal conditions necessary for tDCS to improve behavior in MCS. PMID:27857682

Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats.

PubMed

Dembiński, Artur; Warzecha, Zygmunt; Ceranowicz, Piotr; Dembiński, Marcin; Cieszkowski, Jakub; Gosiewski, Tomasz; Bulanda, Małgorzata; Kuśnierz-Cabala, Beata; Gałązka, Krystyna; Konturek, Peter Christopher

2016-01-01

Background. Inflammatory bowel disease results from the dysregulation of immune response to environmental and microbial agents in genetically susceptible individuals. The aim of the present study was to examine the effect of rifaximin and/or Mutaflor (Escherichia coli Nissle 1917, EcN) administration on the healing of acetic acid-induced colitis. Methods. Colitis was induced in male Wistar rats by rectal enema with 3.5% acetic acid solution. Rifaximin (50 mg/kg/dose) and/or Mutaflor (10(9) CFU/dose) were given intragastrically once a day. The severity of colitis was assessed at the 8th day after induction of inflammation. Results. Treatment with rifaximin significantly accelerated the healing of colonic damage. This effect was associated with significant reversion of the acetic acid-evoked decrease in mucosal blood flow and DNA synthesis. Moreover, administration of rifaximin significantly reduced concentration of proinflammatory TNF-α and activity of myeloperoxidase in colonic mucosa. Mutaflor given alone was without significant effect on activity of colitis. In contrast, Mutaflor given in combination with rifaximin significantly enhanced therapeutic effect of rifaximin. Moreover, Mutaflor led to settle of the colon by EcN and this effect was augmented by pretreatment with rifaximin. Conclusion. Rifaximin and Mutaflor exhibit synergic anti-inflammatory and therapeutic effect in acetic acid-induced colitis in rats.

Spatial and temporal variation in daily temperature indices in summer and winter seasons over India (1969-2012)

NASA Astrophysics Data System (ADS)

Kumar, Naresh; Jaswal, A. K.; Mohapatra, M.; Kore, P. A.

2017-08-01

Spatial and temporal variations in summer and winter extreme temperature indices are studied by using daily maximum and minimum temperatures data from 227 surface meteorological stations well distributed over India for the period 1969-2012. For this purpose, time series for six extreme temperature indices namely, hot days (HD), very hot days (VHD), extremely hot days (EHD), cold nights (CN), very cold nights (VCN), and extremely cold nights (ECN) are calculated for all the stations. In addition, time series for mean extreme temperature indices of summer and winter seasons are also analyzed. Study reveals high variability in spatial distribution of threshold temperatures of extreme temperature indices over the country. In general, increasing trends are observed in summer hot days indices and decreasing trends in winter cold night indices over most parts of the country. The results obtained in this study indicate warming in summer maximum and winter minimum temperatures over India. Averaged over India, trends in summer hot days indices HD, VHD, and EHD are significantly increasing (+1.0, +0.64, and +0.32 days/decade, respectively) and winter cold night indices CN, VCN, and ECN are significantly decreasing (-0.93, -0.47, and -0.15 days/decade, respectively). Also, it is observed that the impact of extreme temperature is higher along the west coast for summer and east coast for winter.

Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients.

PubMed

Cavaliere, Carlo; Aiello, Marco; Di Perri, Carol; Amico, Enrico; Martial, Charlotte; Thibaut, Aurore; Laureys, Steven; Soddu, Andrea

2016-01-01

Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. Although the rising evidences about its possible role in the treatment of many neurological and psychiatric conditions exist, no evidences exist about brain functional connectivity substrates underlying tDCS response. We retrospectively evaluated resting state functional Magnetic Resonance Imaging (fMRI) of 16 sub-acute and chronic MCS patients (6 tDCS responders) who successively received a single left dorsolateral prefrontal cortex (DLPFC) tDCS in a double-blind randomized cross-over trial. A seed-based approach for regions of left extrinsic control network (ECN) and default-mode network (DMN) was performed. tDCS responders showed an increased left intra-network connectivity for regions co-activated with left DLPFC, and significantly with left inferior frontal gyrus. Non-responders (NR) MCS patients showed an increased connectivity between left DLPFC and midline cortical structures, including anterior cingulate cortex and precuneus. Our findings suggest that a prior high connectivity with regions belonging to ECN can facilitate transitory recovery of consciousness in a subgroup of MCS patients that underwent tDCS treatment. Therefore, resting state-fMRI could be very valuable in detecting the neuronal conditions necessary for tDCS to improve behavior in MCS.

24 CFR 320.17 - Fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Fees. 320.17 Section 320.17 Housing... SECURITIES Pass-Through Type Securities § 320.17 Fees. The Association may impose application fees, guaranty fees, securities transfer fees and other fees. ...

49 CFR 1572.405 - Procedures for collection by TSA.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Collection Fee, Threat Assessment Fee, and FBI Fee. (a) Imposition of fees. (1) An individual who applies to... Collection Fee, Threat Assessment Fee, and FBI Fee, in a form and manner approved by TSA, when the individual... accordance with the provisions of 31 U.S.C. 9701 and other applicable Federal law. (3) The FBI Fee required...

49 CFR 1572.405 - Procedures for collection by TSA.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Collection Fee, Threat Assessment Fee, and FBI Fee. (a) Imposition of fees. (1) An individual who applies to... Collection Fee, Threat Assessment Fee, and FBI Fee, in a form and manner approved by TSA, when the individual... accordance with the provisions of 31 U.S.C. 9701 and other applicable Federal law. (3) The FBI Fee required...

48 CFR 2452.216-70 - Estimated cost, base fee and award fee.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Estimated cost, base fee... Provisions and Clauses 2452.216-70 Estimated cost, base fee and award fee. As prescribed in 2416.406(e)(1), insert the following clause in all cost-plus-award-fee contracts: Estimated Cost, Base Fee and Award Fee...

48 CFR 2452.216-70 - Estimated cost, base fee and award fee.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Estimated cost, base fee... Provisions and Clauses 2452.216-70 Estimated cost, base fee and award fee. As prescribed in 2416.406(e)(1), insert the following clause in all cost-plus-award-fee contracts: Estimated Cost, Base Fee and Award Fee...

48 CFR 452.216-71 - Base Fee and Award Fee Proposal.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Base Fee and Award Fee... Base Fee and Award Fee Proposal. As prescribed in 416.470, insert the following provision: Base Fee and Award Proposal (FEB 1988) For the purpose of this solicitation, offerors shall propose a base fee of...

48 CFR 1552.216-75 - Base fee and award fee proposal.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Base fee and award fee... 1552.216-75 Base fee and award fee proposal. As prescribed in 1516.405(b), insert the following clause: Base Fee and Award Fee Proposal (FEB 1999) For the purpose of this solicitation, offerors shall propose...

48 CFR 1552.216-75 - Base fee and award fee proposal.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Base fee and award fee... 1552.216-75 Base fee and award fee proposal. As prescribed in 1516.405(b), insert the following clause: Base Fee and Award Fee Proposal (FEB 1999) For the purpose of this solicitation, offerors shall propose...

48 CFR 1552.216-75 - Base fee and award fee proposal.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Base fee and award fee... 1552.216-75 Base fee and award fee proposal. As prescribed in 1516.405(b), insert the following clause: Base Fee and Award Fee Proposal (FEB 1999) For the purpose of this solicitation, offerors shall propose...

48 CFR 452.216-71 - Base Fee and Award Fee Proposal.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Base Fee and Award Fee... Base Fee and Award Fee Proposal. As prescribed in 416.470, insert the following provision: Base Fee and Award Proposal (FEB 1988) For the purpose of this solicitation, offerors shall propose a base fee of...

78 FR 54942 - Self-Regulatory Organizations; Topaz Exchange, LLC; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-06

... trades in NDX options. See Amex Fee Schedule, Royalty Fees; Arca Fees and Charges, Royalty Fees; BOX Fee... Change To Amend the Schedule of Fees August 30, 2013. Pursuant to Section 19(b)(1) of the Securities... the Proposed Rule Change Topaz is proposing to amend its Schedule of Fees to establish a surcharge fee...

78 FR 47457 - Self-Regulatory Organizations: Miami International Securities Exchange LLC; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-05

... Transaction Fees. The Exchange notes that the fee waiver has no effect on other fees and dues that may apply to Market Makers including marketing fees, Options Regulatory Fees, market data, and membership... transaction fee waiver. \\11\\ The Exchange notes that the fee waiver has no effect on other fees and dues that...

7 CFR 3550.153 - Fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Regular Servicing § 3550.153 Fees. RHS may assess reasonable fees including a tax service fee, fees for late payments, and fees for checks returned for...

7 CFR 3565.302 - Allowable fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

.... (2) Application fee. A fee submitted in conjunction with the application for a loan guarantee. (3) Inspection fee. A fee for inspection of the property in conjunction with a loan guarantee. (4) Transfer fee...

How do Medicare Physician Fees Compare With Private Payers?

PubMed Central

Miller, Mark E.; Zuckerman, Stephen; Gates, Michael

1993-01-01

Under the new fee schedule, Medicare physician fees are 76 percent of private fees. Consistent with the intent of payment reform, Medicare physician fees more closely approximate private fees for visits (93 percent) than for surgery (51 percent) and in rural areas as compared with large metropolitan areas. Variation in private fees across the country is considerably greater than it is for Medicare fees. Consequently, Medicare fees are most generous in areas that compare least favorably with the private market because private fees in these areas are well above average. These results shed light on the impact of the fee schedule and on the implications of using Medicare payment methods as part of a broad-based health reform. PMID:10130578

48 CFR 215.404-74 - Fee requirements for cost-plus-award-fee contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Fee requirements for cost... NEGOTIATION Contract Pricing 215.404-74 Fee requirements for cost-plus-award-fee contracts. In developing a fee objective for cost-plus-award-fee contracts, the contracting officer shall— (a) Follow the...

10 CFR 9.85 - Fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Fees. 9.85 Section 9.85 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Privacy Act Regulations Fees § 9.85 Fees. Fees shall not be charged for search or... available for review, although fees may be charged for additional copies. Fees established under 31 U.S.C...

USFWS demonstration fees

USGS Publications Warehouse

Taylor, Jonathan; Vaske, Jerry; Donnelly, Maureen; Shelby, Lori

2002-01-01

This study examined National Wildlife Refuge (NWR) visitors' reactions to changes in fees implemented as part of the fee demonstration program. Visitors' evaluations of the fees paid were examined in addition to their beliefs about fees and the fee demonstration program, and the impact of fees paid on their intention to return. All results were analyzed relative to socio-demographic characteristics.

13 CFR 120.972 - Third Party Lender participation fee and CDC fee.

Code of Federal Regulations, 2012 CFR

2012-01-01

... fee and CDC fee. 120.972 Section 120.972 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... and CDC fee. (a) Participation fee. For loans approved by SBA after September 30, 1996, SBA must... when the Third Party Lender occupies a senior credit position to SBA in the Project. (b) CDC fee. For...

13 CFR 120.972 - Third Party Lender participation fee and CDC fee.

Code of Federal Regulations, 2011 CFR

2011-01-01

... fee and CDC fee. 120.972 Section 120.972 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... and CDC fee. (a) Participation fee. For loans approved by SBA after September 30, 1996, SBA must... when the Third Party Lender occupies a senior credit position to SBA in the Project. (b) CDC fee. For...

13 CFR 120.972 - Third Party Lender participation fee and CDC fee.

Code of Federal Regulations, 2014 CFR

2014-01-01

... fee and CDC fee. 120.972 Section 120.972 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... and CDC fee. (a) Participation fee. For loans approved by SBA after September 30, 1996, SBA must... when the Third Party Lender occupies a senior credit position to SBA in the Project. (b) CDC fee. For...

13 CFR 120.972 - Third Party Lender participation fee and CDC fee.

Code of Federal Regulations, 2013 CFR

2013-01-01

... fee and CDC fee. 120.972 Section 120.972 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... and CDC fee. (a) Participation fee. For loans approved by SBA after September 30, 1996, SBA must... when the Third Party Lender occupies a senior credit position to SBA in the Project. (b) CDC fee. For...

28 CFR 505.5 - Waiver of fee by Warden.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ADMINISTRATION COST OF INCARCERATION FEE § 505.5 Waiver of fee by Warden. The Warden may reduce or waive the fee... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Waiver of fee by Warden. 505.5 Section... installment schedule, is not likely to become able to pay all or part of the fee, or (b) Imposition of a fee...

UCLA's Molecular Screening Shared Resource: enhancing small molecule discovery with functional genomics and new technology.

PubMed

Damoiseaux, Robert

2014-05-01

The Molecular Screening Shared Resource (MSSR) offers a comprehensive range of leading-edge high throughput screening (HTS) services including drug discovery, chemical and functional genomics, and novel methods for nano and environmental toxicology. The MSSR is an open access environment with investigators from UCLA as well as from the entire globe. Industrial clients are equally welcome as are non-profit entities. The MSSR is a fee-for-service entity and does not retain intellectual property. In conjunction with the Center for Environmental Implications of Nanotechnology, the MSSR is unique in its dedicated and ongoing efforts towards high throughput toxicity testing of nanomaterials. In addition, the MSSR engages in technology development eliminating bottlenecks from the HTS workflow and enabling novel assays and readouts currently not available.

User Fees in Primary Education

ERIC Educational Resources Information Center

Kattan, Raja Bentaouet; Burnett, Nicholas

2004-01-01

There are a large number of different "fees" that private households sometimes have to pay for publicly provided primary education, including tuition fees, textbook fees or costs and/or rental payments, compulsory uniforms, PTA dues, and various special fees such as exam fees, contributions to district education boards, and the like. In many…

49 CFR 1002.3 - Updating user fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... updating fees. Each fee shall be updated by updating the cost components comprising the fee. Cost... direct labor costs are direct labor costs determined by the cost study set forth in Revision of Fees For... by total office costs for the Offices directly associated with user fee activity. Actual updating of...

32 CFR 1285.6 - Fees and fee waivers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Fees and fee waivers. 1285.6 Section 1285.6 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS DEFENSE LOGISTICS AGENCY FREEDOM OF INFORMATION ACT PROGRAM § 1285.6 Fees and fee waivers. The rules and...

36 CFR 1258.12 - NARA reproduction fee schedule.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false NARA reproduction fee... ADMINISTRATION PUBLIC AVAILABILITY AND USE FEES § 1258.12 NARA reproduction fee schedule. (a) Certification: $15...) Unlisted processes: For reproductions not covered by this fee schedule, see also § 1258.4. Fees for other...

36 CFR 1258.12 - NARA reproduction fee schedule.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false NARA reproduction fee... ADMINISTRATION PUBLIC AVAILABILITY AND USE FEES § 1258.12 NARA reproduction fee schedule. (a) Certification: $15...) Unlisted processes: For reproductions not covered by this fee schedule, see also § 1258.4. Fees for other...

22 CFR 51.51 - Passport fees.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Passport fees. 51.51 Section 51.51 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.51 Passport fees. The Department collects the following passport fees in the amounts prescribed in the Schedule of Fees for Consular...

22 CFR 51.51 - Passport fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Passport fees. 51.51 Section 51.51 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.51 Passport fees. The Department collects the following passport fees in the amounts prescribed in the Schedule of Fees for Consular...

22 CFR 51.51 - Passport fees.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Passport fees. 51.51 Section 51.51 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.51 Passport fees. The Department collects the following passport fees in the amounts prescribed in the Schedule of Fees for Consular...

22 CFR 51.51 - Passport fees.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Passport fees. 51.51 Section 51.51 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.51 Passport fees. The Department collects the following passport fees in the amounts prescribed in the Schedule of Fees for Consular...

22 CFR 51.51 - Passport fees.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Passport fees. 51.51 Section 51.51 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.51 Passport fees. The Department collects the following passport fees in the amounts prescribed in the Schedule of Fees for Consular...

32 CFR 1285.6 - Fees and fee waivers.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 6 2012-07-01 2012-07-01 false Fees and fee waivers. 1285.6 Section 1285.6 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS DEFENSE LOGISTICS AGENCY FREEDOM OF INFORMATION ACT PROGRAM § 1285.6 Fees and fee waivers. The rules and...

32 CFR 1285.6 - Fees and fee waivers.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 6 2013-07-01 2013-07-01 false Fees and fee waivers. 1285.6 Section 1285.6 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS DEFENSE LOGISTICS AGENCY FREEDOM OF INFORMATION ACT PROGRAM § 1285.6 Fees and fee waivers. The rules and...

32 CFR 1285.6 - Fees and fee waivers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Fees and fee waivers. 1285.6 Section 1285.6 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS DEFENSE LOGISTICS AGENCY FREEDOM OF INFORMATION ACT PROGRAM § 1285.6 Fees and fee waivers. The rules and...

46 CFR 298.15 - Investigation fee.

Code of Federal Regulations, 2013 CFR

2013-10-01

... an investigation fee. The Letter Commitment will state the fee which is based on the formula in... other administrative expenses. (2) If, for any reason, we disapprove the application, you shall pay one-half of the investigation fees. (b) Base Fee. (1) The investigation fee shall be one-half (1/2) of one...

46 CFR 298.15 - Investigation fee.

Code of Federal Regulations, 2014 CFR

2014-10-01

... an investigation fee. The Letter Commitment will state the fee which is based on the formula in... other administrative expenses. (2) If, for any reason, we disapprove the application, you shall pay one-half of the investigation fees. (b) Base Fee. (1) The investigation fee shall be one-half (1/2) of one...

40 CFR 304.41 - Administrative fees, expenses, and Arbitrator's fee.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Arbitrator's fee. 304.41 Section 304.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... SUPERFUND COST RECOVERY CLAIMS Other Provisions § 304.41 Administrative fees, expenses, and Arbitrator's fee... Association (see § 304.21(e) of this part), all fees and expenses of the arbitral proceeding, including the...

50 CFR 260.74 - Fee for appeal inspection.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Fee for appeal inspection. 260.74 Section... Fishery Products for Human Consumption Fees and Charges § 260.74 Fee for appeal inspection. The fee to be... inspection on which the appeal is made, no inspection fee shall be assessed. ...

50 CFR 260.69 - Payment fees and charges.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Payment fees and charges. 260.69 Section... Fishery Products for Human Consumption Fees and Charges § 260.69 Payment fees and charges. Fees and... services rendered. All fees and charges for any inspection service, performed pursuant to the regulations...

50 CFR 253.16 - Fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Fees. 253.16 Section 253.16 Wildlife and... Fees. (a) Application fee. The Division will not accept an application without the application fee. Fifty percent of the application fee is fully earned at application acceptance, and is not refundable...

22 CFR 504.14 - Fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Fees. 504.14 Section 504.14 Foreign Relations... OFFICIAL INFORMATION IN LEGAL PROCEEDINGS Schedule of Fees § 504.14 Fees. (a) Generally. The General... reasonable estimate of the costs to the BBG. (b) Fees for records. Fees for producing records will include...

49 CFR 665.23 - Fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Fees. 665.23 Section 665.23 Transportation Other... TRANSPORTATION BUS TESTING Operations § 665.23 Fees. (a) The operator shall charge fees in accordance with a schedule approved by FTA, which shall include prorated fees for partial testing. (b) Fees shall be prorated...

Supplementary physicians' fees: a sustainable system?

PubMed

Calcoen, Piet; van de Ven, Wynand P M M

2018-01-25

In Belgium and France, physicians can charge a supplementary fee on top of the tariff set by the mandatory basic health insurance scheme. In both countries, the supplementary fee system is under pressure because of financial sustainability concerns and a lack of added value for the patient. Expenditure on supplementary fees is increasing much faster than total health expenditure. So far, measures taken to curb this trend have not been successful. For certain categories of physicians, supplementary fees represent one-third of total income. For patients, however, the added value of supplementary fees is not that clear. Supplementary fees can buy comfort and access to physicians who refuse to treat patients who are not willing to pay supplementary fees. Perceived quality of care plays an important role in patients' willingness to pay supplementary fees. Today, there is no evidence that physicians who charge supplementary fees provide better quality of care than physicians who do not. However, linking supplementary fees to objectively proven quality of care and limiting access to top quality care to patients able and willing to pay supplementary fees might not be socially acceptable in many countries. Our conclusion is that supplementary physicians' fees are not sustainable.

Use of fees to fund local public health services in Western Massachusetts.

PubMed

Shila Waritu, A; Bulzacchelli, Maria T; Begay, Michael E

2015-01-01

Recent budget cuts have forced many local health departments (LHDs) to cut staff and services. Setting fees that cover the cost of service provision is one option for continuing to fund certain activities. To describe the use of fees by LHDs in Western Massachusetts and determine whether fees charged cover the cost of providing selected services. A cross-sectional descriptive analysis was used to identify the types of services for which fees are charged and the fee amounts charged. A comparative cost analysis was conducted to compare fees charged with estimated costs of service provision. Fifty-nine LHDs in Western Massachusetts. Number of towns charging fees for selected types of services; minimum, maximum, and mean fee amounts; estimated cost of service provision; number of towns experiencing a surplus or deficit for each service; and average size of deficits experienced. Enormous variation exists both in the types of services for which fees are charged and fee amounts charged. Fees set by most health departments did not cover the cost of service provision. Some fees were set as much as $600 below estimated costs. These results suggest that considerations other than costs of service provision factor into the setting of fees by LHDs in Western Massachusetts. Given their limited and often uncertain funding, LHDs could benefit from examining their fee schedules to ensure that the fee amounts charged cover the costs of providing the services. Cost estimates should include at least the health agent's wage and time spent performing inspections and completing paperwork, travel expenses, and cost of necessary materials.

12 CFR 502.75 - What if I do not pay my fees on time?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false What if I do not pay my fees on time? 502.75... FEES Fees § 502.75 What if I do not pay my fees on time? (a) Interest. An examination or investigation fee is delinquent if OTS does not receive the fee within 30 days of the date specified in a bill. The...

8 CFR 1244.20 - Waiver of fees.

Code of Federal Regulations, 2011 CFR

2011-01-01

... TPS registration fee (including the fee for employment authorization, if applicable) shall be considered an essential expenditure. A fee waiver will be granted if the sum of the fees for TPS registration... inability to pay, he or she shall not deny a fee waiver due to the cost of administering the TPS program. (e...

8 CFR 1244.20 - Waiver of fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... TPS registration fee (including the fee for employment authorization, if applicable) shall be considered an essential expenditure. A fee waiver will be granted if the sum of the fees for TPS registration... inability to pay, he or she shall not deny a fee waiver due to the cost of administering the TPS program. (e...

8 CFR 1244.20 - Waiver of fees.

Code of Federal Regulations, 2014 CFR

2014-01-01

... TPS registration fee (including the fee for employment authorization, if applicable) shall be considered an essential expenditure. A fee waiver will be granted if the sum of the fees for TPS registration... inability to pay, he or she shall not deny a fee waiver due to the cost of administering the TPS program. (e...

8 CFR 1244.20 - Waiver of fees.

Code of Federal Regulations, 2013 CFR

2013-01-01

... TPS registration fee (including the fee for employment authorization, if applicable) shall be considered an essential expenditure. A fee waiver will be granted if the sum of the fees for TPS registration... inability to pay, he or she shall not deny a fee waiver due to the cost of administering the TPS program. (e...

8 CFR 1244.20 - Waiver of fees.

Code of Federal Regulations, 2012 CFR

2012-01-01

... TPS registration fee (including the fee for employment authorization, if applicable) shall be considered an essential expenditure. A fee waiver will be granted if the sum of the fees for TPS registration... inability to pay, he or she shall not deny a fee waiver due to the cost of administering the TPS program. (e...

48 CFR 216.405-2 - Cost-plus-award-fee contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Cost-plus-award-fee... Contracts 216.405-2 Cost-plus-award-fee contracts. (b) Application. The cost-plus-award-fee (CPAF) contract... avoid— (1) Establishing cost-plus-fixed-fee contracts when the criteria for cost-plus-fixed-fee...

76 FR 44014 - Generic Drug User Fee; Public Meeting; Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-22

...] Generic Drug User Fee; Public Meeting; Request for Comments AGENCY: Food and Drug Administration, HHS... development of a generic drug user fee program. A user fee program could provide necessary supplemental... generic drug user fees. New legislation would be required for FDA to establish and collect user fees for...

State-of-the-Art Thinking on Parent Fee Policies.

ERIC Educational Resources Information Center

Neugebauer, Roger

1993-01-01

Provides guidance on setting fees and fee policies. Stresses the importance of having fees high enough to adequately reward staff and low enough to be affordable to families. Based on an analysis of over 150 fee policies, discusses rates, multichild discounts, charges for absences, payment terms, registration fees and deposits, withdrawals, late…

76 FR 27114 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-10

... CRD Processing Fee, the NASD Annual System Processing Fee, and the NYSE Arca Transfer/Re-license... Fees, the NASD Annual System Processing Fee, and the NYSE Arca Transfer/Re-license Individual Fee. Fees... Options Regulatory Surveillance Authority (``ORSA'') national market system plan and in doing so shares...

49 CFR 802.15 - Fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Fees. 802.15 Section 802.15 Transportation Other... PRIVACY ACT OF 1974 Fees § 802.15 Fees. No fees shall be charged for providing the first copy of a record, or any portion thereof, to individuals to whom the record pertains. The fee schedule for other...

28 CFR 802.22 - Fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Fees. 802.22 Section 802.22 Judicial... Privacy Act § 802.22 Fees. The Agency shall charge fees under the Privacy Act for duplication of records only. These fees shall be at the same rate the Agency charges for duplication fees under the Freedom of...

22 CFR 33.6 - Fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Fees. 33.6 Section 33.6 Foreign Relations... SECTION 7 § 33.6 Fees. (a) General. Fees provide for administrative costs and payment of claims. Fees are... which fees are payable starts on October 1 and ends on September 30 of the following year. (b) Amount...

7 CFR 4280.126 - Guarantee/annual renewal fee percentages.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Guarantee/annual renewal fee percentages. 4280.126... renewal fee percentages. (a) Fee ceilings. The maximum guarantee fee that may be charged is 1 percent. The maximum annual renewal fee that may be charged is 0.5 percent. The Agency will establish each year the...

15 CFR 930.126 - Consistency appeal processing fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Consistency appeal processing fees... appeal processing fees. The Secretary shall collect as a processing fee such other fees from the... Secretary under section 307(c) of the Act. All processing fees shall be assessed and collected no later than...

75 FR 60487 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-30

... Fingerprint Processing Fee is included as part of this fee. The New Trading Permit Holder Orientation & Exam... Application and related documentation, one Responsible Person's Orientation & Exam Fee and Fingerprint Fee... individuals on a TPH organization's Form BD. This fee includes the related Fingerprint Processing Fee. This...

45 CFR 1609.4 - Accounting for and use of attorneys' fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Accounting for and use of attorneys' fees. 1609.4... CORPORATION FEE-GENERATING CASES § 1609.4 Accounting for and use of attorneys' fees. (a) Attorneys' fees... to support the representation. (b) Attorneys' fees received shall be recorded during the accounting...

Cognitive and default-mode resting state networks: do male and female brains "rest" differently?

PubMed

Weissman-Fogel, Irit; Moayedi, Massieh; Taylor, Keri S; Pope, Geoff; Davis, Karen D

2010-11-01

Variability in human behavior related to sex is supported by neuroimaging studies showing differences in brain activation patterns during cognitive task performance. An emerging field is examining the human connectome, including networks of brain regions that are not only temporally-correlated during different task conditions, but also networks that show highly correlated spontaneous activity during a task-free state. Both task-related and task-free network activity has been associated with individual task performance and behavior under certain conditions. Therefore, our aim was to determine whether sex differences exist during a task-free resting state for two networks associated with cognitive task performance (executive control network (ECN), salience network (SN)) and the default mode network (DMN). Forty-nine healthy subjects (26 females, 23 males) underwent a 5-min task-free fMRI scan in a 3T MRI. An independent components analysis (ICA) was performed to identify the best-fit IC for each network based on specific spatial nodes defined in previous studies. To determine the consistency of these networks across subjects we performed self-organizing group-level ICA analyses. There were no significant differences between sexes in the functional connectivity of the brain areas within the ECN, SN, or the DMN. These important findings highlight the robustness of intrinsic connectivity of these resting state networks and their similarity between sexes. Furthermore, our findings suggest that resting state fMRI studies do not need to be controlled for sex. © 2010 Wiley-Liss, Inc.

Trends in Medicaid physician fees, 2003-2008.

PubMed

Zuckerman, Stephen; Williams, Aimee F; Stockley, Karen E

2009-01-01

Medicaid physician fees increased 15.1 percent, on average, between 2003 and 2008. This was below the general rate of inflation, resulting in a reduction in real fees. Only primary care fees grew at the rate of inflation-20 percent between 2003 and 2008. However, because of slow growth in Medicare fees, Medicaid fees closed a small portion of their ongoing gap relative to Medicare-growing from 69 percent to 72 percent of Medicare. The increase in Medicaid fees relative to Medicare fees resulted from relative increases for primary care and obstetrical services, but not for other services.

43 CFR 2805.16 - If I hold a grant, what monitoring fees must I pay?

Code of Federal Regulations, 2011 CFR

2011-10-01

... categorizes the monitoring fees based on the estimated number of work hours necessary to monitor your grant. Monitoring Category 1 through 4 fees are one-time fees and are not refundable. The work hours and fees for 2005 are as follows: 2005 Monitoring Fee Schedule Monitoring category Federal work hours involved...

Fees at California's Public Colleges and Universities

ERIC Educational Resources Information Center

Fuller, Ryan

2009-01-01

Fees at California's public colleges and universities have increased in the past two decades, but are still lower than fees at comparable institutions in other states. Fees for full-time undergraduate students at the University of California were $8,027 in 2008-09 and fees at California State University were $3,849. Fees are likely to rise for the…

50 CFR 14.94 - What fees apply to me?

Code of Federal Regulations, 2010 CFR

2010-10-01

... diem costs associated with inspection of the shipment. These fees are in place of, not in addition to... Federal holiday. (h) Fee schedule. Inspection fee schedule Fee cost per shipment per year 2008 2009 2010... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false What fees apply to me? 14.94 Section 14.94...

42 CFR 1008.31 - OIG fees for the cost of advisory opinions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false OIG fees for the cost of advisory opinions. 1008.31... SERVICES OIG AUTHORITIES ADVISORY OPINIONS BY THE OIG Advisory Opinion Fees § 1008.31 OIG fees for the cost of advisory opinions. (a) Responsibility for fees. The requestor is responsible for paying a fee...

22 CFR 72.31 - Fees for consular death and estates services.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Fees for consular death and estates services... PROPERTY AND ESTATES DEATHS AND ESTATES Fees § 72.31 Fees for consular death and estates services. (a) Fees for consular death and estates services are prescribed in the Schedule of Fees, 22 CFR 22.1. (b) The...

77 FR 41836 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-16

... Change To Amend OCC's Schedule of Fees to Eliminate Fees for Certain Educational Brochures July 10, 2012... change would amend OCC's Schedule of Fees to eliminate fees for three brochures to reflect that these... OCC's Schedule of Fees to eliminate fees for three brochures to reflect that these brochures are now...

78 FR 66796 - Self-Regulatory Organizations: Miami International Securities Exchange LLC; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-06

... transaction fee for executions in standard option contracts and $0.008 transaction fee for Mini Option... Exchange for purposes of the transaction fee and Section 1(a)(i) of the Fee Schedule include: (i... (``DPLMM''). See MIAX Options Fee Schedule, Section 1(a)(i)--Market Maker Transaction Fees. The current...

13 CFR 120.971 - Allowable fees paid by Borrower.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Development Company Loan Program (504) Fees § 120.971 Allowable fees paid by Borrower. (a) CDC fees. The fees a CDC may charge the Borrower in connection with a 504 loan and Debenture are limited to the following: (1) Processing fee. The CDC may charge up to 1.5 percent of the net Debenture proceeds to process...

13 CFR 120.971 - Allowable fees paid by Borrower.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Development Company Loan Program (504) Fees § 120.971 Allowable fees paid by Borrower. (a) CDC fees. The fees a CDC may charge the Borrower in connection with a 504 loan and Debenture are limited to the following: (1) Processing fee. The CDC may charge up to 1.5 percent of the net Debenture proceeds to process...

13 CFR 120.971 - Allowable fees paid by Borrower.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Development Company Loan Program (504) Fees § 120.971 Allowable fees paid by Borrower. (a) CDC fees. The fees a CDC may charge the Borrower in connection with a 504 loan and Debenture are limited to the following: (1) Processing fee. The CDC may charge up to 1.5 percent of the net Debenture proceeds to process...

13 CFR 120.971 - Allowable fees paid by Borrower.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Development Company Loan Program (504) Fees § 120.971 Allowable fees paid by Borrower. (a) CDC fees. The fees a CDC may charge the Borrower in connection with a 504 loan and Debenture are limited to the following: (1) Processing fee. The CDC may charge up to 1.5 percent of the net Debenture proceeds to process...

13 CFR 120.971 - Allowable fees paid by Borrower.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Development Company Loan Program (504) Fees § 120.971 Allowable fees paid by Borrower. (a) CDC fees. The fees a CDC may charge the Borrower in connection with a 504 loan and Debenture are limited to the following: (1) Processing fee. The CDC may charge up to 1.5 percent of the net Debenture proceeds to process...

48 CFR 915.404-4-71-6 - Fee base.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Fee base. 915.404-4-71-6... CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 915.404-4-71-6 Fee base. (a) The fee base shown... estimate of cost to which a percentage factor is applied to determine maximum fee allowances. The fee base...

48 CFR 915.404-4-71-6 - Fee base.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Fee base. 915.404-4-71-6... CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 915.404-4-71-6 Fee base. (a) The fee base shown... estimate of cost to which a percentage factor is applied to determine maximum fee allowances. The fee base...

48 CFR 915.404-4-71-6 - Fee base.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Fee base. 915.404-4-71-6... CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 915.404-4-71-6 Fee base. (a) The fee base shown... estimate of cost to which a percentage factor is applied to determine maximum fee allowances. The fee base...

46 CFR 2.10-120 - Overseas inspection and examination fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Overseas inspection and examination fees. 2.10-120... VESSEL INSPECTIONS Fees § 2.10-120 Overseas inspection and examination fees. (a) In addition to any other fee required by this subpart, an overseas inspection and examination fee of $4,585 must be paid for...

7 CFR 93.14 - Fees for aflatoxin analysis and fees for testing of other mycotoxins.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 3 2012-01-01 2012-01-01 false Fees for aflatoxin analysis and fees for testing of... AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS PROCESSED FRUITS AND VEGETABLES Peanuts, Tree Nuts, Corn and Other Oilseeds § 93.14 Fees for aflatoxin analysis and fees for testing of other...

7 CFR 93.14 - Fees for aflatoxin analysis and fees for testing of other mycotoxins.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 3 2013-01-01 2013-01-01 false Fees for aflatoxin analysis and fees for testing of... AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS PROCESSED FRUITS AND VEGETABLES Peanuts, Tree Nuts, Corn and Other Oilseeds § 93.14 Fees for aflatoxin analysis and fees for testing of other...

7 CFR 93.14 - Fees for aflatoxin analysis and fees for testing of other mycotoxins.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 3 2014-01-01 2014-01-01 false Fees for aflatoxin analysis and fees for testing of... AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS PROCESSED FRUITS AND VEGETABLES Peanuts, Tree Nuts, Corn and Other Oilseeds § 93.14 Fees for aflatoxin analysis and fees for testing of other...

48 CFR 915.404-4-71-6 - Fee base.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Fee base. 915.404-4-71-6... CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 915.404-4-71-6 Fee base. (a) The fee base shown... estimate of cost to which a percentage factor is applied to determine maximum fee allowances. The fee base...

75 FR 57821 - Self-Regulatory Organizations; C2 Options Exchange, Incorporated; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-22

... been conducted with respect to those CBOE permit holders. In fact, existing CBOE permit holders...), and fingerprint fees ($50) are all being adopted. The proposed fee levels are comparable to those in... 19h-1 change in status fees, exam fees, permit transfer fees, and fingerprint fees will not be charged...

14 CFR 389.21 - Payment of fees.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Payment of fees. 389.21 Section 389.21...) ORGANIZATION FEES AND CHARGES FOR SPECIAL SERVICES Filing and Processing License Fees § 389.21 Payment of fees. (a) Any document or record for which a filing fee is requried by § 389.25 shall be accompanied by...

14 CFR 389.27 - Refund of fee.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Refund of fee. 389.27 Section 389.27...) ORGANIZATION FEES AND CHARGES FOR SPECIAL SERVICES Filing and Processing License Fees § 389.27 Refund of fee... accordance with § 389.23. (b) Any person may file an application for refund of a fee paid since April 28...

14 CFR 389.27 - Refund of fee.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Refund of fee. 389.27 Section 389.27...) ORGANIZATION FEES AND CHARGES FOR SPECIAL SERVICES Filing and Processing License Fees § 389.27 Refund of fee... accordance with § 389.23. (b) Any person may file an application for refund of a fee paid since April 28...

14 CFR 389.21 - Payment of fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Payment of fees. 389.21 Section 389.21...) ORGANIZATION FEES AND CHARGES FOR SPECIAL SERVICES Filing and Processing License Fees § 389.21 Payment of fees. (a) Any document or record for which a filing fee is requried by § 389.25 shall be accompanied by...

22 CFR 72.31 - Fees for consular death and estates services.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Fees for consular death and estates services... PROPERTY AND ESTATES DEATHS AND ESTATES Fees § 72.31 Fees for consular death and estates services. (a) Fees for consular death and estates services are prescribed in the Schedule of Fees, 22 CFR 22.1. (b) The...

22 CFR 72.31 - Fees for consular death and estates services.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Fees for consular death and estates services... PROPERTY AND ESTATES DEATHS AND ESTATES Fees § 72.31 Fees for consular death and estates services. (a) Fees for consular death and estates services are prescribed in the Schedule of Fees, 22 CFR 22.1. (b) The...

22 CFR 72.31 - Fees for consular death and estates services.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Fees for consular death and estates services... PROPERTY AND ESTATES DEATHS AND ESTATES Fees § 72.31 Fees for consular death and estates services. (a) Fees for consular death and estates services are prescribed in the Schedule of Fees, 22 CFR 22.1. (b) The...

Economic Impacts of the Generic Drug User Fee Act Fee Structure.

PubMed

Dong, Ke; Boehm, Garth; Zheng, Qiang

2017-06-01

A Food and Drug Administration (FDA) Generic Drug User system, Generic Drug User Fee Amendment of 2012 (GDUFA), started October 1, 2012, and has been in place for over 3 years. There is controversy about the GDUFA fee structure but no analysis of GDUFA data that we could find. To look at the economic impact of the GDUFA fee structure. We compared the structure of GDUFA with that of other FDA Human Drug User fees. We then, using FDA-published information, analyzed where GDUFA facility and Drug Master File fees are coming from. We used the Orange Book to identify the sponsors of all approved Abbreviated New Drug Applications (ANDAs) and the S&P Capital IQ database to find the ultimate parent companies of sponsors of approved ANDAs. The key differences between the previous structure for Human Drug User fees and the GDUFA are as follows: GDUFA has no approved product fee and no first-time or small business fee exemptions and GDUFA charges facility fees from the time of filing and charges a foreign facility levy. Most GDUFA fees are paid by or on behalf of foreign entities. The top 10 companies hold nearly 50% of all approved ANDAs but pay about 14% of GDUFA facility fees. We conclude that the regressive nature of the GDUFA fee structure penalizes small, new, and foreign firms while benefiting the large established firms. A progressive fee structure in line with other human drug user fees is needed to ensure a healthy generic drug industry. Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

43 CFR 2885.24 - If I hold a grant or TUP, what monitoring fees must I pay?

Code of Federal Regulations, 2011 CFR

2011-10-01

... of work hours necessary to monitor your grant or TUP. Category 1 through 4 monitoring fees are one-time fees and are not refundable. The work hours and fees for 2005 are as follows: 2005 Monitoring Fee Schedule Monitoring category Federal work hours involved Monitoring fee as of June 21, 2005. To be adjusted...

78 FR 28926 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-16

... Establishing Non- Display Usage Fees and Amending the Professional End-User Fees for NYSE Amex Options Market... proposes to establish non-display usage fees and to amend the Professional End-User fees for NYSE Amex... The Exchange proposes to establish non-display usage fees and to amend the Professional End-User fees...

9 CFR 130.10 - User fees for pet birds.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false User fees for pet birds. 130.10... AGRICULTURE USER FEES USER FEES § 130.10 User fees for pet birds. (a) User fees for pet birds of U.S. origin returning to the United States, except pet birds of U.S. origin returning from Canada, are as follows...

9 CFR 130.10 - User fees for pet birds.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false User fees for pet birds. 130.10... AGRICULTURE USER FEES USER FEES § 130.10 User fees for pet birds. (a) User fees for pet birds of U.S. origin returning to the United States, except pet birds of U.S. origin returning from Canada, are as follows...

9 CFR 130.10 - User fees for pet birds.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false User fees for pet birds. 130.10... AGRICULTURE USER FEES USER FEES § 130.10 User fees for pet birds. (a) User fees for pet birds of U.S. origin returning to the United States, except pet birds of U.S. origin returning from Canada, are as follows...

9 CFR 130.10 - User fees for pet birds.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false User fees for pet birds. 130.10... AGRICULTURE USER FEES USER FEES § 130.10 User fees for pet birds. (a) User fees for pet birds of U.S. origin returning to the United States, except pet birds of U.S. origin returning from Canada, are as follows...

9 CFR 130.10 - User fees for pet birds.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false User fees for pet birds. 130.10... AGRICULTURE USER FEES USER FEES § 130.10 User fees for pet birds. (a) User fees for pet birds of U.S. origin returning to the United States, except pet birds of U.S. origin returning from Canada, are as follows...

78 FR 62764 - Self-Regulatory Organizations; Topaz Exchange, LLC; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-22

... in MNX options. See Amex Fee Schedule, Royalty Fees; Arca Fees and Charges, Royalty Fees; and ISE... Change To Amend the Schedule of Fees October 9, 2013. Pursuant to Section 19(b)(1) of the Securities... Terms of the Substance of the Proposed Rule Change Topaz is proposing to amend its Schedule of Fees to...

77 FR 51816 - Notice of Opportunity To Withdraw Abbreviated New Drug Applications To Avoid Backlog Fee Obligations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-27

...] Notice of Opportunity To Withdraw Abbreviated New Drug Applications To Avoid Backlog Fee Obligations... to avoid paying a fee. The fee in question is a one-time backlog fee that was established through enactment of the Generic Drug User Fee Amendments of 2012 (GDUFA). It will apply to any original ANDA that...

9 CFR 130.17 - User fees for other veterinary diagnostic laboratory tests performed at NVSL (excluding FADDL) or...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false User fees for other veterinary... FEES USER FEES § 130.17 User fees for other veterinary diagnostic laboratory tests performed at NVSL (excluding FADDL) or at authorized sites. (a) User fees for veterinary diagnostics tests performed at the...

9 CFR 130.17 - User fees for other veterinary diagnostic laboratory tests performed at NVSL (excluding FADDL) or...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false User fees for other veterinary... FEES USER FEES § 130.17 User fees for other veterinary diagnostic laboratory tests performed at NVSL (excluding FADDL) or at authorized sites. (a) User fees for veterinary diagnostics tests performed at the...

30 CFR 870.13 - Fee rates.

Code of Federal Regulations, 2012 CFR

2012-07-01

... which case the fee charged is 2 percent of the value. (4) In situ coal mining fees. The fee for in situ... produced at the site as certified through analysis by an independent laboratory. The fee for in situ mined... ton.(ii) If value of coal is less than $4.50 per ton, fee is 2 percent of the value. (4) In situ coal...

30 CFR 870.13 - Fee rates.

Code of Federal Regulations, 2013 CFR

2013-07-01

... which case the fee charged is 2 percent of the value. (4) In situ coal mining fees. The fee for in situ... produced at the site as certified through analysis by an independent laboratory. The fee for in situ mined... ton.(ii) If value of coal is less than $4.50 per ton, fee is 2 percent of the value. (4) In situ coal...

30 CFR 870.13 - Fee rates.

Code of Federal Regulations, 2011 CFR

2011-07-01

... which case the fee charged is 2 percent of the value. (4) In situ coal mining fees. The fee for in situ... produced at the site as certified through analysis by an independent laboratory. The fee for in situ mined... ton.(ii) If value of coal is less than $4.50 per ton, fee is 2 percent of the value. (4) In situ coal...

30 CFR 870.13 - Fee rates.

Code of Federal Regulations, 2010 CFR

2010-07-01

... which case the fee charged is 2 percent of the value. (4) In situ coal mining fees. The fee for in situ... produced at the site as certified through analysis by an independent laboratory. The fee for in situ mined... ton.(ii) If value of coal is less than $4.50 per ton, fee is 2 percent of the value. (4) In situ coal...

30 CFR 870.13 - Fee rates.

Code of Federal Regulations, 2014 CFR

2014-07-01

... which case the fee charged is 2 percent of the value. (4) In situ coal mining fees. The fee for in situ... produced at the site as certified through analysis by an independent laboratory. The fee for in situ mined... ton.(ii) If value of coal is less than $4.50 per ton, fee is 2 percent of the value. (4) In situ coal...

Brain synchronization during perception of facial emotional expressions with natural and unnatural dynamics

PubMed Central

Volhard, Jakob; Müller, Viktor; Kaulard, Kathrin; Brick, Timothy R.; Wallraven, Christian; Lindenberger, Ulman

2017-01-01

Research on the perception of facial emotional expressions (FEEs) often uses static images that do not capture the dynamic character of social coordination in natural settings. Recent behavioral and neuroimaging studies suggest that dynamic FEEs (videos or morphs) enhance emotion perception. To identify mechanisms associated with the perception of FEEs with natural dynamics, the present EEG (Electroencephalography)study compared (i) ecologically valid stimuli of angry and happy FEEs with natural dynamics to (ii) FEEs with unnatural dynamics, and to (iii) static FEEs. FEEs with unnatural dynamics showed faces moving in a biologically possible but unpredictable and atypical manner, generally resulting in ambivalent emotional content. Participants were asked to explicitly recognize FEEs. Using whole power (WP) and phase synchrony (Phase Locking Index, PLI), we found that brain responses discriminated between natural and unnatural FEEs (both static and dynamic). Differences were primarily observed in the timing and brain topographies of delta and theta PLI and WP, and in alpha and beta WP. Our results support the view that biologically plausible, albeit atypical, FEEs are processed by the brain by different mechanisms than natural FEEs. We conclude that natural movement dynamics are essential for the perception of FEEs and the associated brain processes. PMID:28723957

Brain synchronization during perception of facial emotional expressions with natural and unnatural dynamics.

PubMed

Perdikis, Dionysios; Volhard, Jakob; Müller, Viktor; Kaulard, Kathrin; Brick, Timothy R; Wallraven, Christian; Lindenberger, Ulman

2017-01-01

Research on the perception of facial emotional expressions (FEEs) often uses static images that do not capture the dynamic character of social coordination in natural settings. Recent behavioral and neuroimaging studies suggest that dynamic FEEs (videos or morphs) enhance emotion perception. To identify mechanisms associated with the perception of FEEs with natural dynamics, the present EEG (Electroencephalography)study compared (i) ecologically valid stimuli of angry and happy FEEs with natural dynamics to (ii) FEEs with unnatural dynamics, and to (iii) static FEEs. FEEs with unnatural dynamics showed faces moving in a biologically possible but unpredictable and atypical manner, generally resulting in ambivalent emotional content. Participants were asked to explicitly recognize FEEs. Using whole power (WP) and phase synchrony (Phase Locking Index, PLI), we found that brain responses discriminated between natural and unnatural FEEs (both static and dynamic). Differences were primarily observed in the timing and brain topographies of delta and theta PLI and WP, and in alpha and beta WP. Our results support the view that biologically plausible, albeit atypical, FEEs are processed by the brain by different mechanisms than natural FEEs. We conclude that natural movement dynamics are essential for the perception of FEEs and the associated brain processes.

48 CFR 16.405-1 - Cost-plus-incentive-fee contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... provides for the initially negotiated fee to be adjusted later by a formula based on the relationship of... minimum fee that may be a zero fee or, in rare cases, a negative fee. (c) Limitations. No cost-plus...

Support for wilderness recreation fees: The influence of fee purpose and day versus overnight use

Treesearch

Christine A. Vogt; Daniel R. Williams

1999-01-01

This paper examines public support for new user fees established at the Desolation Wilderness in California as part of the Fee Demonstration Program. Traditional approaches to fee policy evaluations have typically focused on economic or revenue issues and equity impacts of various pricing strategies. Support for fees has been shown to vary by users in terms of...

36 CFR 51.78 - Will a concession contract require a franchise fee and will the franchise fee be subject to...

Code of Federal Regulations, 2014 CFR

2014-07-01

... require a franchise fee and will the franchise fee be subject to adjustment? 51.78 Section 51.78 Parks... Concession Contract Provisions § 51.78 Will a concession contract require a franchise fee and will the franchise fee be subject to adjustment? (a) Concession contracts will provide for payment to the government...

36 CFR 51.78 - Will a concession contract require a franchise fee and will the franchise fee be subject to...

Code of Federal Regulations, 2011 CFR

2011-07-01

... require a franchise fee and will the franchise fee be subject to adjustment? 51.78 Section 51.78 Parks... Concession Contract Provisions § 51.78 Will a concession contract require a franchise fee and will the franchise fee be subject to adjustment? (a) Concession contracts will provide for payment to the government...

36 CFR 51.78 - Will a concession contract require a franchise fee and will the franchise fee be subject to...

Code of Federal Regulations, 2012 CFR

2012-07-01

... require a franchise fee and will the franchise fee be subject to adjustment? 51.78 Section 51.78 Parks... Concession Contract Provisions § 51.78 Will a concession contract require a franchise fee and will the franchise fee be subject to adjustment? (a) Concession contracts will provide for payment to the government...

36 CFR 51.78 - Will a concession contract require a franchise fee and will the franchise fee be subject to...

Code of Federal Regulations, 2010 CFR

2010-07-01

... require a franchise fee and will the franchise fee be subject to adjustment? 51.78 Section 51.78 Parks... Concession Contract Provisions § 51.78 Will a concession contract require a franchise fee and will the franchise fee be subject to adjustment? (a) Concession contracts will provide for payment to the government...

36 CFR 51.78 - Will a concession contract require a franchise fee and will the franchise fee be subject to...

Code of Federal Regulations, 2013 CFR

2013-07-01

... require a franchise fee and will the franchise fee be subject to adjustment? 51.78 Section 51.78 Parks... Concession Contract Provisions § 51.78 Will a concession contract require a franchise fee and will the franchise fee be subject to adjustment? (a) Concession contracts will provide for payment to the government...

18 CFR 131.43 - Report of securities issued.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... Securities and Exchange Commission registration fee 6. State mortgage registration tax 7. State commission fee 8. Fee for recording indenture 9. United States document tax 10. Printing and engraving expenses 11. Trustee's charges 12. Counsel fees 13. Accountant's fees 14. Cost of listing 15. Miscellaneous...

The `advanced DIR-MCFC development' project, an overview

NASA Astrophysics Data System (ADS)

Kortbeek, P. J.; Ottervanger, R.

An overview is given of the approach and mid-term status of the joint European `Advanced DIR-MCFC Development' project, in which BCN, BG plc, GDF, ECN, Stork, Schelde and Sydkraft co-operate. Hospitals are identified as an attractive initial market for cogeneration direct internal reforming-molten carbonate fuel cell (DIR-MCFC) systems in the size of 400 kWe. Innovative system and stack design concepts are being developed for this application. The `SMARTER' system, based on DIR stacks, combines high electric efficiency and a wide operational window with optimal system simplicity and low cost.

Geautomatiseerde Verwerking van Militaire berichten Volgens ADatP-3 (Automated Processing of Military Messages According to ADatP-3)

DTIC Science & Technology

1992-06-01

ATCCIS beoogt juist dat te bereiken door te werken aan ecn informatie model en een data element dictionary. TNO-rapport Pagina 9 Binnen bet C2...en distributie 44 4.3.2 Interface met de gebruiker 45 4.3.3 Interface met dc operationcle database 46 TNO-rapport Pagina 11 4.3.3.1 Interpretatie...die bezig zijn met het ontwikkelen en implementeren van berichtformaten. Deel I van de publicatie bevat de beschrijving van FORMETS, delen 11 , I11 en

Removing user fees for basic health services: a pilot study and national roll-out in Afghanistan

PubMed Central

Steinhardt, Laura C; Aman, Iqbal; Pakzad, Iqbalshah; Kumar, Binay; Singh, Lakhwinder P; Peters, David H

2011-01-01

Background User fees for primary care tend to suppress utilization, and many countries are experimenting with fee removal. Studies show that additional inputs are needed after removing fees, although well-documented experiences are lacking. This study presents data on the effects of fee removal on facility quality and utilization in Afghanistan, based on a pilot experiment and subsequent nationwide ban on fees. Methods Data on utilization and observed structural and perceived overall quality of health care were compared from before-and-after facility assessments, patient exit interviews and catchment area household surveys from eight facilities where fees were removed and 14 facilities where fee levels remained constant, as part of a larger health financing pilot study from 2005 to 2007. After a national user fee ban was instituted in 2008, health facility administrative data were analysed to assess subsequent changes in utilization and quality. Results The pilot study analysis indicated that observed and perceived quality increased across facilities but did not differ by fee removal status. Difference-in-difference analysis showed that utilization at facilities previously charging both service and drug fees increased by 400% more after fee removal, prompting additional inputs from service providers, compared with facilities that previously only charged service fees or had no change in fees (P = 0.001). Following the national fee ban, visits for curative care increased significantly (P < 0.001), but institutional deliveries did not. Services typically free before the ban—immunization and antenatal care—had immediate increases in utilization but these were not sustained. Conclusion Both pilot and nationwide data indicated that curative care utilization increased following fee removal, without differential changes in quality. Concerns raised by non-governmental organizations, health workers and community leaders over the effects of lost revenue and increased utilization require continued effort to raise revenues, monitor health worker and patient perceptions, and carefully manage health facility performance. PMID:22027924

50 CFR 25.53 - Establishment of single visit entrance fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... fees. 25.53 Section 25.53 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM ADMINISTRATIVE PROVISIONS Fees and Charges § 25.53 Establishment of single visit entrance fees. Entrance fees established for single visit...

77 FR 5178 - Fees

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-02

... penalty from the fee calculation is not adopted. 514.17 How are fingerprint processing fees collected by the Commission? Comment: Two commenters objected to fingerprint fees being included as a separate... fingerprints and not all tribes utilize the service. The service will continue to be charged as a separate fee...

7 CFR 205.642 - Fees and other charges for certification.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Fees and other charges for certification. 205.642...) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Fees § 205.642 Fees and other charges for certification. Fees charged by a certifying agent must be reasonable, and a certifying...

4 CFR 201.9 - Restrictions on charging fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 4 Accounts 1 2010-01-01 2010-01-01 false Restrictions on charging fees. 201.9 Section 201.9 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PUBLIC INFORMATION AND REQUESTS § 201.9 Restrictions on charging fees. (a) When determining search or review fees: (1) No search fee shall be charged...

48 CFR 16.304 - Cost-plus-incentive-fee contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cost-plus-incentive-fee...-incentive-fee contracts. A cost-plus-incentive-fee contract is a cost-reimbursement contract that provides... allowable costs to total target costs. Cost-plus-incentive-fee contracts are covered in subpart 16.4...

75 FR 3987 - Annual Update of Filing Fees

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-26

... updating is to adjust the fees on the basis of the Commission's costs for Fiscal Year 2009. DATES... fees on the basis of the Commission's Fiscal Year 2009 costs. The adjusted fees announced in this...] Annual Update of Filing Fees January 20, 2010. AGENCY: Federal Energy Regulatory Commission. ACTION...

77 FR 10650 - Annual Update of Filing Fees

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-23

... updating is to adjust the fees on the basis of the Commission's costs for Fiscal Year 2011. DATES... establishing updated fees on the basis of the Commission's Fiscal Year 2011 costs. The adjusted fees announced...] Annual Update of Filing Fees AGENCY: Federal Energy Regulatory Commission, DOE. ACTION: Final rule...

28 CFR 505.3 - Inmates exempted from fee assessment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... AND ADMINISTRATION COST OF INCARCERATION FEE § 505.3 Inmates exempted from fee assessment. Inmates who... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Inmates exempted from fee assessment. 505... Guidelines, or any successor provisions, are exempt from fee assessment otherwise required by this part. ...

78 FR 2880 - Annual Update of Filing Fees

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-15

... updating is to adjust the fees on the basis of the Commission's costs for Fiscal Year 2012. DATES... establishing updated fees on the basis of the Commission's Fiscal Year 2012 costs. The adjusted fees announced...] Annual Update of Filing Fees AGENCY: Federal Energy Regulatory Commission, DOE. ACTION: Final rule...

32 CFR 310.20 - Reproduction fees.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Reproduction fees. 310.20 Section 310.20... PROGRAM DOD PRIVACY PROGRAM Access by Individuals § 310.20 Reproduction fees. (a) Assessing fees. (1) Charge the individual only the direct cost of reproduction. (2) Do not charge reproduction fees if...

32 CFR 310.20 - Reproduction fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Reproduction fees. 310.20 Section 310.20... PROGRAM DOD PRIVACY PROGRAM Access by Individuals § 310.20 Reproduction fees. (a) Assessing fees. (1) Charge the individual only the direct cost of reproduction. (2) Do not charge reproduction fees if...

40 CFR 700.41 - Radon user fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Radon user fees. 700.41 Section 700.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT GENERAL Fees § 700.41 Radon user fees. User fees relating to radon proficiency programs authorized under the...

22 CFR 51.55 - Execution fee not refundable.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Execution fee not refundable. 51.55 Section 51.55 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.55 Execution fee not refundable. The fee for the execution of a passport application is not refundable. ...

22 CFR 22.1 - Schedule of fees.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Schedule of Fees for Consular Services: Schedule of Fees for Consular Services Item No. Fee Passport and Citizenship Services 1. Passport Book or Card Execution: Required for first-time applicants and others who... application pay only one execution fee.) $25. 2. Passport Book Application Services for: (a) Applicants age 16...

22 CFR 51.55 - Execution fee not refundable.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Execution fee not refundable. 51.55 Section 51.55 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.55 Execution fee not refundable. The fee for the execution of a passport application is not refundable. ...

22 CFR 51.55 - Execution fee not refundable.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Execution fee not refundable. 51.55 Section 51.55 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.55 Execution fee not refundable. The fee for the execution of a passport application is not refundable. ...

22 CFR 51.55 - Execution fee not refundable.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Execution fee not refundable. 51.55 Section 51.55 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.55 Execution fee not refundable. The fee for the execution of a passport application is not refundable. ...

22 CFR 22.1 - Schedule of fees.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Schedule of Fees for Consular Services: Schedule of Fees for Consular Services Item No. Fee Passport and Citizenship Services 1. Passport Book or Card Execution: Required for first-time applicants and others who... application pay only one execution fee.) $25. 2. Passport Book Application Services for: (a) Applicants age 16...

22 CFR 22.1 - Schedule of fees.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Schedule of Fees for Consular Services: Schedule of Fees for Consular Services Item No. Fee Passport and Citizenship Services 1. Passport Book or Card Execution: Required for first-time applicants and others who... application pay only one execution fee.) $25. 2. Passport Book Application Services for: (a) Applicants age 16...

22 CFR 51.55 - Execution fee not refundable.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Execution fee not refundable. 51.55 Section 51.55 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.55 Execution fee not refundable. The fee for the execution of a passport application is not refundable. ...

22 CFR 22.1 - Schedule of fees.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Schedule of Fees for Consular Services: Schedule of Fees for Consular Services Item No. Fee Passport and Citizenship Services 1. Passport Book or Card Execution: Required for first-time applicants and others who... application pay only one execution fee.) $25. 2. Passport Book Application Services for: (a) Applicants age 16...

Royalty Fees Part I: The Copyright Clearance Center and Publishers.

ERIC Educational Resources Information Center

Eiblum, Paula; Ardito, Stephanie C.

1998-01-01

Discussion of copyrights, royalty fees, and intellectual property focuses on the Copyright Clearance Center and publishers. Topics include results of a survey of library and information science journal publishers; how users verify royalty fees; how publishers determine fees; royalty fee reporting; and terms and conditions imposed on electronic…

22 CFR 303.13 - Fees.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Fees. 303.13 Section 303.13 Foreign Relations PEACE CORPS PROCEDURES FOR DISCLOSURE OF INFORMATION UNDER THE FREEDOM OF INFORMATION ACT § 303.13 Fees...) Special delivery or express mail: Actual charges as incurred. (f) Fee waivers: Fees will be waived or...

22 CFR 303.13 - Fees.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Fees. 303.13 Section 303.13 Foreign Relations PEACE CORPS PROCEDURES FOR DISCLOSURE OF INFORMATION UNDER THE FREEDOM OF INFORMATION ACT § 303.13 Fees...) Special delivery or express mail: Actual charges as incurred. (f) Fee waivers: Fees will be waived or...

40 CFR 700.41 - Radon user fees.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Radon user fees. 700.41 Section 700.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT GENERAL Fees § 700.41 Radon user fees. User fees relating to radon proficiency programs authorized under the...

48 CFR 970.5215-1 - Total available fee: Base fee amount and performance fee amount.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Profit, and Other Incentives—Facility Management Contracts” if contained in the contract. (d) Performance... fee amount and performance fee amount. 970.5215-1 Section 970.5215-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS...

7 CFR 504.3 - Payment of fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Payment of fees. 504.3 Section 504.3 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE USER FEES § 504.3 Payment of fees. (a) Payment of user fees must accompany a culture deposit or...

48 CFR 403.405 - Misrepresentations or violations of the Covenant Against Contingent Fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... violations of the Covenant Against Contingent Fees. 403.405 Section 403.405 Federal Acquisition Regulations... Contingent Fees 403.405 Misrepresentations or violations of the Covenant Against Contingent Fees. (a) A suspected misrepresentation or violation of the Covenant Against Contingent Fees shall be documented in...

47 CFR 1.339 - Witness fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Witness fees. 1.339 Section 1.339....339 Witness fees. Witnesses who are subpenaed and respond thereto are entitled to the same fees, including mileage, as are paid for like service in the courts of the United States. Fees shall be paid by...

47 CFR 1.1166 - Waivers, reductions and deferrals of regulatory fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... fees. 1.1166 Section 1.1166 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND... deferrals of regulatory fees. The fees established by sections 1.1152 through 1.1156 may be waived, reduced... waiver, reduction or deferral of the fee would promote the public interest. Requests for waivers...

22 CFR 1002.7 - Fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Fees. 1002.7 Section 1002.7 Foreign Relations INTER-AMERICAN FOUNDATION AVAILABILITY OF RECORDS § 1002.7 Fees. Except as otherwise specifically provided by the Foundation, a fee will be levied for all searches for, or copies of, records. These fees...

22 CFR 1502.7 - Fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Fees. 1502.7 Section 1502.7 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION AVAILABILITY OF RECORDS § 1502.7 Fees. (a) When charged. Fees shall be... information primarily benefits the general public. Fees shall also not be charged where they would amount, in...

22 CFR 707.23 - Fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Fees. 707.23 Section 707.23 Foreign Relations... INFORMATION IN RECORDS OF THE CORPORATION Notification; Access to Records; Amendment; Fees § 707.23 Fees. The fees to be charged by the Corporation for making copies of any records provided to any individual under...

5 CFR 185.127 - Fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Fees. 185.127 Section 185.127... § 185.127 Fees. The party requesting a subpoena shall pay the cost of the fees and mileage of any... District Court. A check for witness fees and mileage shall accompany the subpoena when served, except that...

14 CFR 389.13 - Fees for services.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Fees for services. 389.13 Section 389.13 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ORGANIZATION FEES AND CHARGES FOR SPECIAL SERVICES Fees for Special Services § 389.13 Fees for services. Except...

14 CFR 389.13 - Fees for services.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Fees for services. 389.13 Section 389.13 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ORGANIZATION FEES AND CHARGES FOR SPECIAL SERVICES Fees for Special Services § 389.13 Fees for services. Except...

A study on effects of and stance over tuition fees.

PubMed

Karay, Yassin; Matthes, Jan

2016-01-01

Regarding tuition fees (that in Germany already have been abrogated) putative drawbacks like prolonged study duration have been suspected while benefits are not clearly proven. We investigated whether tuition fees (500 Euro per semester) affected the course of studies of Cologne medical students and asked for students' stance over tuition fees. Of 1,324 students we analyzed the rate of those passing their first medical exam ("Physikum") within minimum time and students' discontinuation rate, respectively. Regression analysis tested for putative influences of tuition fees and demographic factors. In an additional online survey 400 students answered questions regarding the load by and their stance over tuition fees. We find that fees did not affect rate of Cologne students passing their first medical exam within minimum time or students' discontinuation rate. According to the online survey, at times of tuition fees significantly more students did not attend courses as scheduled. Time spent on earning money was significantly increased. 51% of students who had to pay tuition fees and 71% of those who never had to stated tuition fees to be not justified. More than two thirds of students did not recognize any lasting benefit from tuition fees. Tuition fees did not affect discontinuation rate or study duration of Cologne medical students. However, they obviously influenced the study course due to an increased need to pursue a sideline. Cologne medical students rather refused tuition fees and did not recognize their advantages in terms of enhanced quality of studies.

A study on effects of and stance over tuition fees

PubMed Central

Karay, Yassin; Matthes, Jan

2016-01-01

Aim: Regarding tuition fees (that in Germany already have been abrogated) putative drawbacks like prolonged study duration have been suspected while benefits are not clearly proven. We investigated whether tuition fees (500 Euro per semester) affected the course of studies of Cologne medical students and asked for students’ stance over tuition fees. Methods: Of 1,324 students we analyzed the rate of those passing their first medical exam (“Physikum”) within minimum time and students’ discontinuation rate, respectively. Regression analysis tested for putative influences of tuition fees and demographic factors. In an additional online survey 400 students answered questions regarding the load by and their stance over tuition fees. Results: We find that fees did not affect rate of Cologne students passing their first medical exam within minimum time or students’ discontinuation rate. According to the online survey, at times of tuition fees significantly more students did not attend courses as scheduled. Time spent on earning money was significantly increased. 51% of students who had to pay tuition fees and 71% of those who never had to stated tuition fees to be not justified. More than two thirds of students did not recognize any lasting benefit from tuition fees. Conclusion: Tuition fees did not affect discontinuation rate or study duration of Cologne medical students. However, they obviously influenced the study course due to an increased need to pursue a sideline. Cologne medical students rather refused tuition fees and did not recognize their advantages in terms of enhanced quality of studies. PMID:26958654

Fee Splitting among General Practitioners: A Cross-Sectional Study in Iran.

PubMed

Parsa, Mojtaba; Larijani, Bagher; Aramesh, Kiarash; Nedjat, Saharnaz; Fotouhi, Akbar; Yekaninejad, Mir Saeed; Ebrahimian, Nejatollah; Kandi, Mohamad Jafar

2016-12-01

Fee splitting is a process whereby a physician refers a patient to another physician or a healthcare facility and receives a portion of the charge in return. This survey was conducted to study general practitioners' (GPs) attitudes toward fee splitting as well as the prevalence, causes, and consequences of this process. This is a cross-sectional study on 223 general practitioners in 2013. Concerning the causes and consequences of fee splitting, an unpublished qualitative study was conducted by interviewing a number of GPs and specialists and the questionnaire options were the results of the information obtained from this study. Of the total 320 GPs, 247 returned the questionnaires. The response rate was 77.18%. Of the 247 returned questionnaires, 223 fulfilled the inclusion criteria. Among the participants, 69.1% considered fee splitting completely wrong and 23.2% (frequently or rarely) practiced fee splitting. The present study showed that the prevalence of fee splitting among physicians who had positive attitudes toward fee splitting was 4.63 times higher than those who had negative attitudes. In addition, this study showed that, compared to private hospitals, fee splitting is less practiced in public hospitals. The major cause of fee splitting was found to be unrealistic/unfair tariffs and the main consequence of fee splitting was thought to be an increase in the number of unnecessary patient referrals. Fee splitting is an unethical act, contradicts the goals of the medical profession, and undermines patient's best interest. In Iran, there is no code of ethics on fee splitting, but in this study, it was found that the majority of GPs considered it unethical. However, among those who had negative attitudes toward fee splitting, there were physicians who did practice fee splitting. The results of the study showed that physicians who had a positive attitude toward fee splitting practiced it more than others. Therefore, if physicians consider fee splitting unethical, its rate will certainly decrease. The study claims that to decrease such practice, the healthcare system has to revise the tariffs.

76 FR 62632 - NARA Records Reproduction Fees

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

... methodology for creating and changing records reproduction fees, to remove records reproduction fees found in... add the methodology for creating and changing records reproduction fees, to remove records...

32 CFR 204.9 - Schedule of fees and rates.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Schedule of fees and rates. 204.9 Section 204.9 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS USER FEES § 204.9 Schedule of fees and rates. (a) Schedule of fees and rates. (1) This schedule...

32 CFR 204.5 - Fees.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Fees. 204.5 Section 204.5 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS USER FEES § 204.5 Fees. (a) General. (1) All fees shall be based on full cost to the U.S. Government or market...

47 CFR 1.1167 - Error claims related to regulatory fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Challenges to determinations or an insufficient regulatory fee payment or delinquent fees should be made in writing. A challenge to a determination that a party is delinquent in paying a standard regulatory fee... 47 Telecommunication 1 2010-10-01 2010-10-01 false Error claims related to regulatory fees. 1.1167...

4 CFR 200.7 - Fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 4 Accounts 1 2010-01-01 2010-01-01 false Fees. 200.7 Section 200.7 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PRIVACY ACT OF 1974 § 200.7 Fees. A fee will not be charged for searching, reviewing, or making corrections to records. A fee for copying will be assessed at the same rate established...

22 CFR 1101.11 - Fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Fees. 1101.11 Section 1101.11 Foreign Relations INTERNATIONAL BOUNDARY AND WATER COMMISSION, UNITED STATES AND MEXICO, UNITED STATES SECTION PRIVACY ACT OF 1974 § 1101.11 Fees. (a) Under the Act, fees can only be charged for the cost of copying records. No fees may...

48 CFR 1852.216-85 - Estimated cost and award fee.

Code of Federal Regulations, 2010 CFR

2010-10-01

... and Clauses 1852.216-85 Estimated cost and award fee. As prescribed in 1816.406-70(e), insert the following clause: Estimated Cost and Award Fee (SEP 1993) The estimated cost of this contract is $___. The... cost, base fee, and maximum award fee are $___. (End of clause) Alternate I (SEP 1993). As prescribed...

7 CFR 28.115 - Fees and costs; payment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Fees and costs; payment. 28.115 Section 28.115... Fees and Costs § 28.115 Fees and costs; payment. All charges for practical forms of cotton standards and all fees and expenses for services of inspection of bales and supervision of sampling...

48 CFR 16.306 - Cost-plus-fixed-fee contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cost-plus-fixed-fee...-fee contracts. (a) Description. A cost-plus-fixed-fee contract is a cost-reimbursement contract that.... The fixed fee does not vary with actual cost, but may be adjusted as a result of changes in the work...

4 CFR 28.89 - Attorney's fees and costs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 4 Accounts 1 2010-01-01 2010-01-01 false Attorney's fees and costs. 28.89 Section 28.89 Accounts... Procedures Board Decisions, Attorney's Fees and Judicial Review § 28.89 Attorney's fees and costs. Within 20... party, may submit a request for the award of reasonable attorney's fees and costs. GAO may file a...

48 CFR 1316.405-2 - Cost-plus-award-fee contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Cost-plus-award-fee... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 1316.405-2 Cost-plus-award-fee contracts. Insert clause 1352.216-72, Determination of Award Fee, in all cost-plus-award-fee contracts. ...

Fees at California's Public Colleges and Universities. Report 10-01

ERIC Educational Resources Information Center

Fuller, Ryan

2010-01-01

Fees at California's public colleges and universities have increased considerably with the current state budget crisis, but are still lower than fees at comparable institutions in other states. At California State University (CSU), fees for full-time undergraduate students are $4,893 for the 2009-10 school year. Fees at the University of…

48 CFR 1852.216-74 - Estimated cost and fixed fee.

Code of Federal Regulations, 2010 CFR

2010-10-01

... and Clauses 1852.216-74 Estimated cost and fixed fee. As prescribed in 1816.307-70(b), insert the following clause: Estimated Cost and Fixed Fee (DEC 1991) The estimated cost of this contract is ______ exclusive of the fixed fee of ______. The total estimated cost and fixed fee is ______. (End of clause) [62...

76 FR 24035 - Generic Drug User Fee; Public Meeting; Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-29

...] Generic Drug User Fee; Public Meeting; Request for Comments AGENCY: Food and Drug Administration, HHS... development of a generic drug user fee program. A user fee program could provide necessary supplemental... announcing its intention to hold a public meeting related to generic drug user fees. The Agency continues to...

48 CFR 1852.216-77 - Award fee for end item contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Contractor's performance for the entire contract will be evaluated to determine total earned award fee. No award fee or base fee will be paid to the Contractor if the final award fee evaluation is “poor... the Contractor's interim performance every 6* months to monitor Contractor performance prior to...

44 CFR 6.82 - Waiver of fee.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SECURITY GENERAL IMPLEMENTATION OF THE PRIVACY ACT OF 1974 Fees § 6.82 Waiver of fee. The system manager... collecting the fee is an unduly large part of, or greater than, the fee, or when furnishing the record without charge conforms to generally established business custom or is in the public interest. [44 FR...

36 CFR 1258.2 - What does the NARA reproduction fee schedule cover?

Code of Federal Regulations, 2010 CFR

2010-07-01

... reproduction fee schedule cover? 1258.2 Section 1258.2 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE FEES § 1258.2 What does the NARA reproduction fee schedule cover? The NARA reproduction fee schedule in § 1258.12 covers reproduction of: (a) NARA...

36 CFR 1258.2 - What does the NARA reproduction fee schedule cover?

Code of Federal Regulations, 2011 CFR

2011-07-01

... reproduction fee schedule cover? 1258.2 Section 1258.2 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE FEES § 1258.2 What does the NARA reproduction fee schedule cover? The NARA reproduction fee schedule in § 1258.12 covers reproduction of: (a) NARA...

22 CFR 96.8 - Fees charged by accrediting entities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Fees charged by accrediting entities. 96.8... Duties of Accrediting Entities § 96.8 Fees charged by accrediting entities. (a) An accrediting entity may... fees approved by the Secretary. Before approving a schedule of fees proposed by an accrediting entity...

48 CFR 215.404-75 - Fee requirements for FFRDCs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Contract Pricing 215.404-75 Fee requirements for FFRDCs. For nonprofit organizations that are FFRDCs, the... ordinary and necessary to the FFRDC. (b) Shall, when a fee is considered appropriate, establish the fee objective in accordance with FFRDC fee policies in the DoD FFRDC Management Plan. (c) Shall not use the...

48 CFR 215.404-75 - Fee requirements for FFRDCs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Contract Pricing 215.404-75 Fee requirements for FFRDCs. For nonprofit organizations that are FFRDCs, the... ordinary and necessary to the FFRDC. (b) Shall, when a fee is considered appropriate, establish the fee objective in accordance with FFRDC fee policies in the DoD FFRDC Management Plan. (c) Shall not use the...

12 CFR 12.6 - Fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Fees. 12.6 Section 12.6 Banks and Banking... SECURITIES TRANSACTIONS § 12.6 Fees. A national bank may charge a reasonable fee for providing notification pursuant to § 12.5(b), (c), and (e). A national bank may not charge a fee for providing notification...

25 CFR 307.6 - Fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false Fees. 307.6 Section 307.6 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR NAVAJO ALL-WOOL WOVEN FABRICS; USE OF GOVERNMENT CERTIFICATE OF GENUINENESS § 307.6 Fees. Each licensee shall pay a registration fee of $2, together with a license fee which...

10 CFR 1705.10 - Fees.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Fees. 1705.10 Section 1705.10 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.10 Fees. A fee will not be charged for search or review of requested records, or for correction of records. When a request is made for copies of records, a copying fee...

78 FR 10228 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-13

... transaction fee for XSP index options. Currently, the Exchange has a $0.18 customer transaction fee per... customer transaction fees for transactions in XSP index options. Eliminating the customer transaction fee... opportunity to pay lower fees for such transactions and provide greater incentives for customers to trade XSP...

77 FR 60738 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-04

... which fees are applicable to the variety of transactions available on CBOE. No substantive changes to... Fees Schedule and clarifications are being given. Currently, broker-dealer transaction fees apply to... transaction fees, there is no separate listing of fees for non-Trading Permit Holder market-makers (only...

49 CFR 1572.403 - Procedures for collection by States.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Threat Assessment Fee and the FBI Fee. (a) Imposition of fees. (1) An individual who applies to obtain or... FBI Fee, in a form and manner approved by TSA and the State, when the individual submits the... other applicable Federal law. (3) The FBI Fee required for the FBI to process fingerprint identification...

49 CFR 1572.403 - Procedures for collection by States.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Threat Assessment Fee and the FBI Fee. (a) Imposition of fees. (1) An individual who applies to obtain or... FBI Fee, in a form and manner approved by TSA and the State, when the individual submits the... other applicable Federal law. (3) The FBI Fee required for the FBI to process fingerprint identification...

77 FR 24480 - Application for New Awards; Advanced Placement (AP) Test Fee Program-Reopening the AP Test Fee...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-24

... DEPARTMENT OF EDUCATION Application for New Awards; Advanced Placement (AP) Test Fee Program--Reopening the AP Test Fee Fiscal Year 2012 Competition AGENCY: Office of Elementary and Secondary Education (OESE), Department of Education. ACTION: Notice reopening the AP Test Fee fiscal year 2012 competition...

10 CFR 1304.107 - Fees.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Fees. 1304.107 Section 1304.107 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.107 Fees. A fee will not be charged for searching, reviewing, or making corrections to records. A fee for copying will be assessed at the same rate established...

10 CFR 1304.107 - Fees.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Fees. 1304.107 Section 1304.107 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.107 Fees. A fee will not be charged for searching, reviewing, or making corrections to records. A fee for copying will be assessed at the same rate established...

10 CFR 1304.107 - Fees.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Fees. 1304.107 Section 1304.107 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.107 Fees. A fee will not be charged for searching, reviewing, or making corrections to records. A fee for copying will be assessed at the same rate established...

10 CFR 1303.109 - Restrictions on charging fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Restrictions on charging fees. 1303.109 Section 1303.109 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PUBLIC INFORMATION AND REQUESTS § 1303.109 Restrictions on charging fees. (a) When determining search or review fees: (1) No search or review fee shall be charged for...

10 CFR 1304.107 - Fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Fees. 1304.107 Section 1304.107 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.107 Fees. A fee will not be charged for searching, reviewing, or making corrections to records. A fee for copying will be assessed at the same rate established...

10 CFR 1304.107 - Fees.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Fees. 1304.107 Section 1304.107 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.107 Fees. A fee will not be charged for searching, reviewing, or making corrections to records. A fee for copying will be assessed at the same rate established...

36 CFR 1007.9 - Fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

....9 Fees. (a) Policy. (1) Unless waived pursuant to the provisions of § 1007.10, fees for responding... Presidio Trust, and the requester has not sought and been granted a full waiver of fees under § 1007.10... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Fees. 1007.9 Section 1007.9...

47 CFR 76.933 - Franchising authority review of basic cable rates and equipment costs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... the imposition of, or increase in, franchise fees or Commission cable television system regulatory..., the increased rate attributable to Commission regulatory fees or franchise fees shall be treated as an... increase in basic tier rates exceeds the increase in regulatory fees or in franchise fees allocable to the...

47 CFR 76.933 - Franchising authority review of basic cable rates and equipment costs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the imposition of, or increase in, franchise fees or Commission cable television system regulatory..., the increased rate attributable to Commission regulatory fees or franchise fees shall be treated as an... increase in basic tier rates exceeds the increase in regulatory fees or in franchise fees allocable to the...

47 CFR 76.933 - Franchising authority review of basic cable rates and equipment costs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... the imposition of, or increase in, franchise fees or Commission cable television system regulatory..., the increased rate attributable to Commission regulatory fees or franchise fees shall be treated as an... increase in basic tier rates exceeds the increase in regulatory fees or in franchise fees allocable to the...

47 CFR 76.933 - Franchising authority review of basic cable rates and equipment costs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... the imposition of, or increase in, franchise fees or Commission cable television system regulatory..., the increased rate attributable to Commission regulatory fees or franchise fees shall be treated as an... increase in basic tier rates exceeds the increase in regulatory fees or in franchise fees allocable to the...

22 CFR 1101.11 - Fees.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Fees. 1101.11 Section 1101.11 Foreign Relations INTERNATIONAL BOUNDARY AND WATER COMMISSION, UNITED STATES AND MEXICO, UNITED STATES SECTION PRIVACY ACT OF 1974 § 1101.11 Fees. (a) Under the Act, fees can only be charged for the cost of copying records. No fees may...

48 CFR 970.1504-1-7 - Fee base.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Fee base. 970.1504-1-7... REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contracting by Negotiation 970.1504-1-7 Fee base. (a) The fee base is an estimate of necessary allowable costs, with some exclusions. It is used in the fee...

48 CFR 970.1504-1-7 - Fee base.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Fee base. 970.1504-1-7... REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contracting by Negotiation 970.1504-1-7 Fee base. (a) The fee base is an estimate of necessary allowable costs, with some exclusions. It is used in the fee...

48 CFR 970.1504-1-7 - Fee base.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Fee base. 970.1504-1-7... REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contracting by Negotiation 970.1504-1-7 Fee base. (a) The fee base is an estimate of necessary allowable costs, with some exclusions. It is used in the fee...

5 CFR 1655.21 - Loan fee.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Loan fee. 1655.21 Section 1655.21 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD LOAN PROGRAM § 1655.21 Loan fee. The TSP will charge a participant a $50.00 loan fee when it disburses the loan and will deduct the fee from the...

10 CFR 1705.10 - Fees.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Fees. 1705.10 Section 1705.10 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.10 Fees. A fee will not be charged for search or review of requested records, or for correction of records. When a request is made for copies of records, a copying fee...

10 CFR 1705.10 - Fees.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Fees. 1705.10 Section 1705.10 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.10 Fees. A fee will not be charged for search or review of requested records, or for correction of records. When a request is made for copies of records, a copying fee...

12 CFR 950.6 - Fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Fees. 950.6 Section 950.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK ASSETS AND OFF-BALANCE SHEET ITEMS ADVANCES Advances to Members § 950.6 Fees. (a) Fees in member products policy. All fees charged by each Bank and any...

76 FR 28106 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-13

... PHLX LLC Relating to Rebates and Fees for Adding and Removing Liquidity May 9, 2011. Pursuant to... its Fee Schedule titled ``Rebates and Fees for Adding and Removing Liquidity in Select Symbols. \\3\\ A... the Exchange's Fee Schedule, entitled ``Complex Order.'' Currently, the Fees for Removing Liquidity...

46 CFR 4.11-10 - Witness fees and allowances.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Witness fees and allowances. 4.11-10 Section 4.11-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC MARINE CASUALTIES AND INVESTIGATIONS Witnesses and Witness Fees § 4.11-10 Witness fees and allowances. Witness fees and...

Private Schools and Public Benefit: Fees, Fee Remissions, and Subsidies

ERIC Educational Resources Information Center

Davies, Peter

2011-01-01

The level of fee remissions offered by private schools bears upon the scope for relying on private schools to provide public benefit. Analyses of education voucher systems have generally ignored the possibility that they will partially crowd out school-financed fee remissions. Moreover, variation in fee remissions between private schools may be…

45 CFR 2105.5 - Fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Fees. 2105.5 Section 2105.5 Public Welfare.... 552, THE FREEDOM OF INFORMATION ACT § 2105.5 Fees. (a) Fees shall be charged according to the schedule... been notified that it cannot be determined in advance whether any records will be made available, fees...

50 CFR 260.70 - Schedule of fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Schedule of fees. 260.70 Section 260.70... Products for Human Consumption Fees and Charges § 260.70 Schedule of fees. (a) Unless otherwise provided in a written agreement between the applicant and the Secretary, the fees to be charged and collected...

50 CFR 260.73 - Disposition of fees for inspections made under cooperative agreement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Disposition of fees for inspections made... CERTIFICATION Inspection and Certification of Establishments and Fishery Products for Human Consumption Fees and Charges § 260.73 Disposition of fees for inspections made under cooperative agreement. Fees for inspection...

47 CFR 1.1160 - Refunds of regulatory fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Refunds of regulatory fees. 1.1160 Section 1... Statutory Charges and Procedures for Payment § 1.1160 Refunds of regulatory fees. (a) Regulatory fees will be refunded, upon request, only in the following instances: (1) When no regulatory fee is required or...

50 CFR 29.5 - Fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Fees. 29.5 Section 29.5 Wildlife and... WILDLIFE REFUGE SYSTEM LAND USE MANAGEMENT General Rules § 29.5 Fees. Fees and charges for the grant of... prescribed by law or regulation, shall be set at a rate commensurate with fees and charges for similar...

50 CFR 260.72 - Fees for inspection service performed under cooperative agreement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Fees for inspection service performed... CERTIFICATION Inspection and Certification of Establishments and Fishery Products for Human Consumption Fees and Charges § 260.72 Fees for inspection service performed under cooperative agreement. The fees to be charged...

48 CFR 452.216-70 - Award Fee.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Award Fee. 452.216-70... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 452.216-70 Award Fee. As prescribed in 416.405, insert a clause substantially as follows: Award Fee (FEB 1988) The amount of award fee...

48 CFR 225.7303-4 - Contingent fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contingent fees. 225.7303....7303-4 Contingent fees. (a) Except as provided in paragraph (b) of this subsection, contingent fees are generally allowable under DoD contracts, provided— (1) The fees are paid to a bona fide employee or a bona...

48 CFR 303.405 - Misrepresentations or violations of the Covenant Against Contingent Fees clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... violations of the Covenant Against Contingent Fees clause. 303.405 Section 303.405 Federal Acquisition... INTEREST Contingent Fees 303.405 Misrepresentations or violations of the Covenant Against Contingent Fees... Covenant Against Contingent Fees clause to the Contracting Officer. (b)(4) The HCA shall provide a copy of...

50 CFR 501.9 - Fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Fees. 501.9 Section 501.9 Wildlife and Fisheries MARINE MAMMAL COMMISSION IMPLEMENTATION OF THE PRIVACY ACT OF 1974 § 501.9 Fees. A fee of $0.10... request of an individual. No fee shall be charged for copies made at the initiative of the Commission...

10 CFR 1008.13 - Fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Fees. 1008.13 Section 1008.13 Energy DEPARTMENT OF ENERGY... § 1008.13 Fees. (a) The only fees to be charged to or collected from an individual under the provisions of this part are for copying records at the request of the individual. The fee charged shall be...

25 CFR 700.251 - Fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false Fees. 700.251 Section 700.251 Indians THE OFFICE OF... § 700.251 Fees. (a) Services for which fees may be charged. (1) Unless waived pursuant to the provisions of paragraph (c) of this section, user fees shall be charged for document search and duplication...

31 CFR 16.25 - Fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Fees. 16.25 Section 16.25 Money and... REMEDIES ACT OF 1986 § 16.25 Fees. The party requesting a subpoena shall pay the cost of the fees and... United States District Court. A check for witness fees and mileage shall accompany the subpoena when...

20 CFR 498.210 - Fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Fees. 498.210 Section 498.210 Employees... § 498.210 Fees. The party requesting a subpoena will pay the cost of the fees and mileage of any witness.... A check for witness fees and mileage will accompany the subpoena when served, except that when a...

45 CFR 503.9 - Fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Fees. 503.9 Section 503.9 Public Welfare... Regulations § 503.9 Fees. Fees to be charged, if any, to any individual for making copies of that individual's... or because those services are required by some other law, the question of charging fees for those...

16 CFR 1025.49 - Fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Fees. 1025.49 Section 1025.49 Commercial... § 1025.49 Fees. (a) Fees for deponents and witnesses. Any person compelled to appear in person in response to a subpoena or notice of deposition shall be paid the same attendance and mileage fees as are...

34 CFR 5b.13 - Fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Fees. 5b.13 Section 5b.13 Education Office of the Secretary, Department of Education PRIVACY ACT REGULATIONS § 5b.13 Fees. (a) Policy. Where applicable, fees for copying records will be charged in accordance with the schedule set forth in this section. Fees...

30 CFR 256.63 - Service fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Service fees. 256.63 Section 256.63 Mineral... IN THE OUTER CONTINENTAL SHELF Assignments, Transfers, and Extensions § 256.63 Service fees. (a) The table in this paragraph (a) shows the fees that you must pay to MMS for the services listed. The fees...

77 FR 18287 - Self-Regulatory Organizations; C2 Options Exchange, Incorporated; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-27

... Exchange currently lists on its Fees Schedule the fingerprint processing fees that are collected and... facilities. The proposed change is reasonable because the fees for fingerprint processing will now be lower... new, lower fingerprint processing fees will apply to all eligible parties. Further, this fee is not...

10 CFR 1705.10 - Fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Fees. 1705.10 Section 1705.10 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.10 Fees. A fee will not be charged for search or review of requested records, or for correction of records. When a request is made for copies of records, a copying fee...

10 CFR 1705.10 - Fees.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Fees. 1705.10 Section 1705.10 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD PRIVACY ACT § 1705.10 Fees. A fee will not be charged for search or review of requested records, or for correction of records. When a request is made for copies of records, a copying fee...

Analysis of Tuition and Fees.

ERIC Educational Resources Information Center

California Community Colleges, Sacramento. Office of the Chancellor.

A study was conducted by the Chancellor's Office of the California Community Colleges (CCC) to examine the consequences of existing fee policies and the likely impact of possible changes in the fee structures. The study simulated the consequences of three different fee proposals for the CCC system: an annual fee increase of $50 ($30 for those…

32 CFR 766.11 - Fees for landing, parking and storage.

Code of Federal Regulations, 2010 CFR

2010-07-01

... aircraft will be charged fees if their government charges similar fees for U.S. Government aircraft. (2... (Regular and Reserve) or retired, provided the aircraft is not used for commercial purposes. (7) Landing... landing), a landing fee in excess of the normal landing fee will be charged to cover the additional...

78 FR 78447 - Self-Regulatory Organizations; Topaz Exchange, LLC; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-26

... Commission is publishing this notice to solicit comments on the proposed rule change from interested persons... fees include membership application fees, access and CMM trading right fees, network and gateway fees... appointments from CMMs based on their performance. Network & Gateway Fees The Exchange is proposing to charge...

Fee Comparisons of Treatments for Nonmelanoma Skin Cancer in a Private Practice Academic Setting

PubMed Central

Wilson, Leslie S.; Pregenzer, Mark; Basu, Rituparna; Bertenthal, Daniel; Torres, Jeanette; Asgari, Maryam; Chren, Mary-Margaret

2013-01-01

OBJECTIVE To compare fees for biopsy, treatment procedure, repair, and 2-month follow-up for nonmelanoma skin cancer (NMSC) treatments: electrodesiccation and curettage (ED&C), excision, and Mohs micrographic surgery (MMS). METHODS A cost comparison of 936 primary NMSCs diagnosed in 1999/2000 at a University affiliated dermatology practice. Clinical data was from medical record review. 2007 Medicare Fee Schedule costs determined fees for surgical care. Pearson chi-square tests, t-tests and analysis of variance compared fee differences. Linear regression determined independent effects of tumor and treatment characteristics on fees. RESULTS Mean fees/lesion were $463 for ED&C, $1,222 for excision, and $2,085 for MMS (p < .001). For all treatments, primary procedure costs were highest (38%, 45%, and 41%). Total repair fees were higher with MMS ($735) vs excisions ($197). Fees were higher for head and neck tumors (p < .001), H-zone tumors (p < .001), and tumors smaller than 10 mm in diameter (p = .04). Regression models predicted that the treatment fees would be $2,109 for MMS and $1,252 for excision (p < .001). Tumor size greater than 10 mm in diameter (added $128), tumors on the head and neck (added $966), and MMS (added $857 vs excision) were independently related to higher fees (p < .001). CONCLUSION Even after adjusting for risk factors, MMS has higher fees than excision for primary NMSC. Repairs accounted for the majority of this difference. These fee comparisons provide a basis for comparative effectiveness studies of treatments for this common cancer. PMID:22145798

40 CFR 304.41 - Administrative fees, expenses, and Arbitrator's fee.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS ARBITRATION PROCEDURES FOR SMALL SUPERFUND COST RECOVERY CLAIMS Other Provisions § 304.41 Administrative fees, expenses, and Arbitrator's fee...

40 CFR 304.41 - Administrative fees, expenses, and Arbitrator's fee.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS ARBITRATION PROCEDURES FOR SMALL SUPERFUND COST RECOVERY CLAIMS Other Provisions § 304.41 Administrative fees, expenses, and Arbitrator's fee...

40 CFR 304.41 - Administrative fees, expenses, and Arbitrator's fee.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS ARBITRATION PROCEDURES FOR SMALL SUPERFUND COST RECOVERY CLAIMS Other Provisions § 304.41 Administrative fees, expenses, and Arbitrator's fee...

48 CFR 915.404-4-72 - Special considerations for cost-plus-award-fee contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... cost-plus-award-fee contracts. 915.404-4-72 Section 915.404-4-72 Federal Acquisition Regulations System....404-4-72 Special considerations for cost-plus-award-fee contracts. (a) When a contract is to be awarded on a cost-plus-award-fee basis several special considerations are appropriate. Fee objectives for...

Graduate Fees at California's Public Universities. FS 08-02

ERIC Educational Resources Information Center

California Postsecondary Education Commission, 2008

2008-01-01

Fees for graduate students at California's public colleges and universities have risen over the last several years, but are still lower than fees at comparable universities in other states. Fees for full-time graduate students at the California State University were $4,163 in 2007-08. This amount consists of $3,414 in systemwide fees plus…

48 CFR 1852.216-84 - Estimated cost and incentive fee.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Provisions and Clauses 1852.216-84 Estimated cost and incentive fee. As prescribed in 1816.406-70(d), insert the following clause: Estimated Cost and Incentive Fee (OCT 1996) The target cost of this contract is $___. The target fee of this contract is $___. The total target cost and target fee as contemplated by the...

29 CFR 25.7 - Fees; cost; expenses; decisions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Fees; cost; expenses; decisions. 25.7 Section 25.7 Labor... ORDER 10988 § 25.7 Fees; cost; expenses; decisions. (a) Arbitrator's fees, per diem and travel expenses... entirely by the agency. (b) The standard fee for the services of an arbitrator should be $100 per day...

48 CFR 1552.211-73 - Level of effort-cost-reimbursement term contract.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contracts without fee, cost-sharing contracts, cost-plus-fixed-fee (CPFF) contracts, cost-plus-incentive-fee contracts (CPIF), and cost-plus-award-fee contracts (CPAF). Level of Effort—Cost-Reimbursement Term Contract... additional effort shall not result in any increase in the fixed fee, if any. If this is a cost-plus-incentive...

77 FR 69522 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-19

... participants to: (1) Charge a flat fee per quotation update; (2) charge a separate flat fee per quotation... to: (1) Charge a flat fee per quotation update; (2) charge a separate flat fee per quotation update... fund the NSX's regulatory oversight of Order Delivery participants. Quotation Update Fee for Existing...

25 CFR 514.5 - When must a tribe pay its annual fees?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 2 2014-04-01 2014-04-01 false When must a tribe pay its annual fees? 514.5 Section 514.5 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS FEES § 514.5 When must a tribe pay its annual fees? Each gaming operation shall calculate the amount of fees...

25 CFR 514.5 - When must a tribe pay its annual fees?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false When must a tribe pay its annual fees? 514.5 Section 514.5 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS FEES § 514.5 When must a tribe pay its annual fees? Each gaming operation shall calculate the amount of fees...

75 FR 55678 - Minerals Management: Adjustment of Cost Recovery Fees

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-14

... text to the general cost recovery fee table so that mineral cost recovery fees can be found in one... Coal and Oil Shale) Program's lease renewal fee will increase from $480 to $485; (C) The Mining Law... $2,840; and (D) The Mining Law Administration Program's fee for mineral patent adjudication of 10 or...

12 CFR 602.11 - Fees by type of requester.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Fees by type of requester. 602.11 Section 602... Fees § 602.11 Fees by type of requester. Depending on your identity and the purpose of your request... a commercial use. (b) Representatives of the news media. We charge fees for reproduction costs only...

12 CFR 602.11 - Fees by type of requester.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Fees by type of requester. 602.11 Section 602... Fees § 602.11 Fees by type of requester. Depending on your identity and the purpose of your request... a commercial use. (b) Representatives of the news media. We charge fees for reproduction costs only...

22 CFR 51.52 - Exemption from payment of passport fees.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Exemption from payment of passport fees. 51.52 Section 51.52 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.52 Exemption from payment of passport fees. (a) A person who is exempt from the payment of passport fees under...

22 CFR 51.52 - Exemption from payment of passport fees.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Exemption from payment of passport fees. 51.52 Section 51.52 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.52 Exemption from payment of passport fees. (a) A person who is exempt from the payment of passport fees under...

22 CFR 51.52 - Exemption from payment of passport fees.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Exemption from payment of passport fees. 51.52 Section 51.52 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.52 Exemption from payment of passport fees. (a) A person who is exempt from the payment of passport fees under...

22 CFR 51.52 - Exemption from payment of passport fees.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Exemption from payment of passport fees. 51.52 Section 51.52 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.52 Exemption from payment of passport fees. (a) A person who is exempt from the payment of passport fees under...

22 CFR 51.52 - Exemption from payment of passport fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Exemption from payment of passport fees. 51.52 Section 51.52 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Fees § 51.52 Exemption from payment of passport fees. (a) A person who is exempt from the payment of passport fees under...

49 CFR 1572.403 - Procedures for collection by States.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Threat Assessment Fee and the FBI Fee. (a) Imposition of fees. (1) The following Threat Assessment Fee is... applies to obtain or renew an HME: $34. (2) The following FBI Fee is required for the FBI to process... FBI under Pub. L. 101-515. (3) An individual who applies to obtain or renew an HME, or the individual...

49 CFR 1572.403 - Procedures for collection by States.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Threat Assessment Fee and the FBI Fee. (a) Imposition of fees. (1) The following Threat Assessment Fee is... applies to obtain or renew an HME: $34. (2) The following FBI Fee is required for the FBI to process... FBI under Pub. L. 101-515. (3) An individual who applies to obtain or renew an HME, or the individual...

49 CFR 1572.403 - Procedures for collection by States.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Threat Assessment Fee and the FBI Fee. (a) Imposition of fees. (1) The following Threat Assessment Fee is... applies to obtain or renew an HME: $34. (2) The following FBI Fee is required for the FBI to process... FBI under Pub. L. 101-515. (3) An individual who applies to obtain or renew an HME, or the individual...

75 FR 78806 - Agency Information Collection (Create Payment Request for the VA Funding Fee Payment System (VA...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-16

... Payment Request for the VA Funding Fee Payment System (VA FFPS); a Computer Generated Funding Fee Receipt.... 2900-0474.'' SUPPLEMENTARY INFORMATION: Title: Create Payment Request for the VA Funding Fee Payment System (VA FFPS); a Computer Generated Funding Fee Receipt, VA Form 26-8986. OMB Control Number: 2900...

76 FR 31823 - Technical Amendment to List of User Fee Airports: Addition of Dallas Love Field Municipal Airport...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-02

...] Technical Amendment to List of User Fee Airports: Addition of Dallas Love Field Municipal Airport, Dallas... fee airport designation for Dallas Love Field Municipal Airport, in Dallas, Texas. User fee airports... Love Field Municipal Airport. This document updates the list of user fee airports by adding Dallas Love...

48 CFR 970.5215-3 - Conditional payment of fee, profit, and other incentives-facility management contracts

Code of Federal Regulations, 2013 CFR

2013-10-01

... period, the DOE Operations/Field Office Manager, or designee, may reduce any otherwise earned fee, fixed... prescribed in 970.1504-5(b)(1), insert the following clause: Conditional Payment of Fee, Profit, and Other Incentives—Facility Management Contracts (AUG 2009) (a) General. (1) The payment of earned fee, fixed fee...

78 FR 46970 - Medical Device User Fee Rates for Fiscal Year 2014

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-02

...] Medical Device User Fee Rates for Fiscal Year 2014 AGENCY: Food and Drug Administration, HHS. ACTION... procedures for medical device user fees for fiscal year (FY) 2014. The Federal Food, Drug, and Cosmetic Act.... The FY 2014 fee rates are provided in this document. These fees apply from October 1, 2013, through...

15 CFR 18.8 - Rulemaking on maximum rates for attorney fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... attorney fees. 18.8 Section 18.8 Commerce and Foreign Trade Office of the Secretary of Commerce ATTORNEY'S FEES AND OTHER EXPENSES General Provisions § 18.8 Rulemaking on maximum rates for attorney fees. (a) If... attorney fees. The petition should be sent to the General Counsel, Department of Commerce, 14th Street and...

Reality Investing | Alaska Division of Retirement and Benefits

Science.gov Websites

account for you. An annual fee based on your account balance will be assessed to your account quarterly . For instance, if you have a $10,000 account balance, the annual fee to have your account managed for chart below for the fee schedule. Managed Account Service Annual Fees Account Balance Annual Fee Less

7 CFR 51.44 - Disposition of fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Disposition of fees. 51.44 Section 51.44 Agriculture... Schedule of Fees and Charges at Destination Markets § 51.44 Disposition of fees. (a) The fees collected for... charges collected pursuant to §§ 51.40 to 51.41 shall be remitted to the Agricultural Marketing Service...

7 CFR 51.44 - Disposition of fees.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 2 2011-01-01 2011-01-01 false Disposition of fees. 51.44 Section 51.44 Agriculture... Schedule of Fees and Charges at Destination Markets § 51.44 Disposition of fees. (a) The fees collected for... charges collected pursuant to §§ 51.40 to 51.41 shall be remitted to the Agricultural Marketing Service...

77 FR 43408 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-24

... Change Amending the NYSE Arca Equities Schedule of Fees and Charges for Exchange Services July 18, 2012... the NYSE Arca Equities Schedule of Fees and Charges for Exchange Services (``Fee Schedule''). The... Exchange proposes to amend the Fee Schedule, as described below, and implement the fee changes on July 12...

22 CFR 22.6 - Refund of fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Refund of fees. 22.6 Section 22.6 Foreign... FOREIGN SERVICE § 22.6 Refund of fees. (a) Fees which have been collected for deposit in the Treasury are refundable: (1) As specifically authorized by law (See 22 U.S.C. 214a concerning passport fees erroneously...

22 CFR 22.6 - Refund of fees.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Refund of fees. 22.6 Section 22.6 Foreign... FOREIGN SERVICE § 22.6 Refund of fees. (a) Fees which have been collected for deposit in the Treasury are refundable: (1) As specifically authorized by law (See 22 U.S.C. 214a concerning passport fees erroneously...

22 CFR 22.6 - Refund of fees.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Refund of fees. 22.6 Section 22.6 Foreign... FOREIGN SERVICE § 22.6 Refund of fees. (a) Fees which have been collected for deposit in the Treasury are refundable: (1) As specifically authorized by law (See 22 U.S.C. 214a concerning passport fees erroneously...

22 CFR 22.6 - Refund of fees.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Refund of fees. 22.6 Section 22.6 Foreign... FOREIGN SERVICE § 22.6 Refund of fees. (a) Fees which have been collected for deposit in the Treasury are refundable: (1) As specifically authorized by law (See 22 U.S.C. 214a concerning passport fees erroneously...

22 CFR 22.6 - Refund of fees.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Refund of fees. 22.6 Section 22.6 Foreign... FOREIGN SERVICE § 22.6 Refund of fees. (a) Fees which have been collected for deposit in the Treasury are refundable: (1) As specifically authorized by law (See 22 U.S.C. 214a concerning passport fees erroneously...

45 CFR 1627.4 - Membership fees or dues.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Membership fees or dues. 1627.4 Section 1627.4... AND MEMBERSHIP FEES OR DUES § 1627.4 Membership fees or dues. (a) LSC funds may not be used to pay membership fees or dues to any private or nonprofit organization, whether on behalf of a recipient or an...

46 CFR 5.401 - Payment of witness fees and allowances.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Payment of witness fees and allowances. 5.401 Section 5... INVESTIGATION REGULATIONS-PERSONNEL ACTION Witness Fees § 5.401 Payment of witness fees and allowances. (a) Duly... (Standard Form 1157) accompanied by any necessary receipts. (b) Fees and allowances will be paid as provided...

43 CFR 35.25 - Fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Fees. 35.25 Section 35.25 Public Lands... STATEMENTS § 35.25 Fees. The party requesting a subpoena shall pay the cost of the fees and mileage of any... Court. A check for witness fees and mileage shall accompany the subpoena when served, except that when a...

47 CFR 1.742 - Place of filing, fees, and number of copies.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Place of filing, fees, and number of copies. 1..., fees, and number of copies. All applications which do not require a fee shall be filed at the... then forwarded to the Wireline Competition Bureau. All applications accompanied by a fee payment should...

46 CFR 2.10-125 - Fees for examination of foreign tankships.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Fees for examination of foreign tankships. 2.10-125... VESSEL INSPECTIONS Fees § 2.10-125 Fees for examination of foreign tankships. Each foreign tankship of a..., or examination for the annual endorsement to a Certificate of Compliance, a fee of $1,100. (b) For...

43 CFR 30.252 - May a judge allow fees for attorneys representing interested parties?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false May a judge allow fees for attorneys... Interior INDIAN PROBATE HEARINGS PROCEDURES Miscellaneous Provisions § 30.252 May a judge allow fees for... allow fees for attorneys representing interested parties. (1) At the discretion of the judge, these fees...

31 CFR 323.5 - Fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Fees. 323.5 Section 323.5 Money and... TREASURY BUREAU OF THE PUBLIC DEBT DISCLOSURE OF RECORDS § 323.5 Fees. The fees provided in part 1 of title... assignment. (e) Fees may be waived for other classes of requested records upon a finding by the Commissioner...

78 FR 16830 - Notice of New Fee Site

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-19

... New Fee Site AGENCY: Rio Grande National Forest, USDA Forest Service. ACTION: Notice of New Fee Site... Forest is proposing to add a cabin for rent to the public for a $50 fee for the overnight rental. It was.... People are invited to comment on this proposal. DATES: Send any comments about these fee proposals by...

18 CFR 1301.21 - Fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Fees. 1301.21 Section... § 1301.21 Fees. (a) Fees to be charged, if any, to any individual for making copies of his or her record exclude the cost of any search and review of the record. The following fees are applicable: (1) For...

7 CFR 91.38 - Additional fees for appeal of analysis.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Additional fees for appeal of analysis. 91.38 Section... LABORATORY TESTING PROGRAMS SERVICES AND GENERAL INFORMATION Fees and Charges § 91.38 Additional fees for appeal of analysis. (a) The applicant for appeal sample testing will be charged a fee at the hourly rate...

7 CFR 91.38 - Additional fees for appeal of analysis.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 3 2013-01-01 2013-01-01 false Additional fees for appeal of analysis. 91.38 Section... LABORATORY TESTING PROGRAMS SERVICES AND GENERAL INFORMATION Fees and Charges § 91.38 Additional fees for appeal of analysis. (a) The applicant for appeal sample testing will be charged a fee at the hourly rate...

9 CFR 130.15 - User fees for veterinary diagnostic isolation and identification tests performed at NVSL...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false User fees for veterinary diagnostic isolation and identification tests performed at NVSL (excluding FADDL) or other authorized site. 130.15... AGRICULTURE USER FEES USER FEES § 130.15 User fees for veterinary diagnostic isolation and identification...

9 CFR 130.15 - User fees for veterinary diagnostic isolation and identification tests performed at NVSL...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false User fees for veterinary diagnostic isolation and identification tests performed at NVSL (excluding FADDL) or other authorized site. 130.15... AGRICULTURE USER FEES USER FEES § 130.15 User fees for veterinary diagnostic isolation and identification...

9 CFR 130.14 - User fees for FADDL veterinary diagnostics.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false User fees for FADDL veterinary..., DEPARTMENT OF AGRICULTURE USER FEES USER FEES § 130.14 User fees for FADDL veterinary diagnostics. (a... 167.00 Rabbit antiserum, any agent 1 mL 179.00 185.00 190.00 196.00 (b) Veterinary diagnostics tests...

9 CFR 130.14 - User fees for FADDL veterinary diagnostics.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false User fees for FADDL veterinary..., DEPARTMENT OF AGRICULTURE USER FEES USER FEES § 130.14 User fees for FADDL veterinary diagnostics. (a... 167.00 Rabbit antiserum, any agent 1 mL 179.00 185.00 190.00 196.00 (b) Veterinary diagnostics tests...

25 CFR 514.17 - How are fingerprint processing fees collected by the Commission?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 2 2014-04-01 2014-04-01 false How are fingerprint processing fees collected by the... GENERAL PROVISIONS FEES § 514.17 How are fingerprint processing fees collected by the Commission? (a) Fees for processing fingerprint cards will be billed monthly to each Tribe for cards processed during the...

25 CFR 514.17 - How are fingerprint processing fees collected by the Commission?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false How are fingerprint processing fees collected by the... GENERAL PROVISIONS FEES § 514.17 How are fingerprint processing fees collected by the Commission? (a) Fees for processing fingerprint cards will be billed monthly to each Tribe for cards processed during the...

Alternative Fuels Data Center

Science.gov Websites

and Vehicle Efficiency Fees Beginning January 1, 2020, all-electric vehicle (EV) owners must pay an annual fee of $110. Beginning January 1, 2022, EV owners must pay a fee of $115. Medium-speed EV owners must pay an annual fee of $58. All other vehicles must pay an annual fee in the following amounts

Excessive coupling of the salience network with intrinsic neurocognitive brain networks during rectal distension in adolescents with irritable bowel syndrome: a preliminary report

PubMed Central

Liu, Xiaolin; Silverman, Alan; Kern, Mark; Ward, B. Douglas; Li, Shi-Jiang; Shaker, Reza; Sood, Manu R.

2015-01-01

Background The neural network mechanisms underlying visceral hypersensitivity in irritable bowel syndrome (IBS) are incompletely understood. It has been proposed that an intrinsic salience network plays an important role in chronic pain and IBS symptoms. Using neuroimaging, we examined brain responses to rectal distension in adolescent IBS patients, focusing on determining the alteration of salience network integrity in IBS and its functional implications in current theoretical frameworks. We hypothesized that (1) brain responses to visceral stimulation in adolescents are similar to those in adults, and (2) IBS is associated with an altered salience network interaction with other neurocognitive networks, particularly the default mode network (DMN) and executive control network (ECN), as predicted by the theoretical models. Methods IBS patients and controls received subliminal and liminal rectal distension during imaging. Stimulus-induced brain activations were determined. Salience network integrity was evaluated by functional connectivity of its seed regions activated by rectal distension in the insular and cingulate cortices. Key Results Compared with controls, IBS patients demonstrated greater activation to rectal distension in neural structures of the homeostatic afferent and emotional arousal networks, especially the anterior cingulate and insular cortices. Greater brain responses to liminal vs. subliminal distension were observed in both groups. Particularly, IBS is uniquely associated with an excessive coupling of the salience network with the DMN and ECN in their key frontal and parietal node areas. Conclusions & Inferences Our study provided consistent evidence supporting the theoretical predictions of altered salience network functioning as a neuropathological mechanism of IBS symptoms. PMID:26467966

Probabilistic atlases of default mode, executive control and salience network white matter tracts: an fMRI-guided diffusion tensor imaging and tractography study

PubMed Central

Figley, Teresa D.; Bhullar, Navdeep; Courtney, Susan M.; Figley, Chase R.

2015-01-01

Diffusion tensor imaging (DTI) is a powerful MRI technique that can be used to estimate both the microstructural integrity and the trajectories of white matter pathways throughout the central nervous system. This fiber tracking (aka, “tractography”) approach is often carried out using anatomically-defined seed points to identify white matter tracts that pass through one or more structures, but can also be performed using functionally-defined regions of interest (ROIs) that have been determined using functional MRI (fMRI) or other methods. In this study, we performed fMRI-guided DTI tractography between all of the previously defined nodes within each of six common resting-state brain networks, including the: dorsal Default Mode Network (dDMN), ventral Default Mode Network (vDMN), left Executive Control Network (lECN), right Executive Control Network (rECN), anterior Salience Network (aSN), and posterior Salience Network (pSN). By normalizing the data from 32 healthy control subjects to a standard template—using high-dimensional, non-linear warping methods—we were able to create probabilistic white matter atlases for each tract in stereotaxic coordinates. By investigating all 198 ROI-to-ROI combinations within the aforementioned resting-state networks (for a total of 6336 independent DTI tractography analyses), the resulting probabilistic atlases represent a comprehensive cohort of functionally-defined white matter regions that can be used in future brain imaging studies to: (1) ascribe DTI or other white matter changes to particular functional brain networks, and (2) compliment resting state fMRI or other functional connectivity analyses. PMID:26578930

Generation and validation of oxygenated volatile organic carbon standards for the 1995 Southern Oxidants Study Nashville Intensive

NASA Astrophysics Data System (ADS)

Apel, E. C.; Calvert, J. G.; Greenberg, J. P.; Riemer, D.; Zika, R.; Kleindienst, T. E.; Lonneman, W. A.; Fung, K.; Fujita, E.

1998-09-01

Two volatile organic compound (VOC) mixtures were made available and utilized for the calibration of instruments and intercomparison exercises at the Youth, Inc. (YI) site during the Southern Oxidants Study Nashville Intensive. Cylinder 1, made by Scott-Marrin, Inc., contained 14 components (3 nonmethane hydrocarbons (NMHCs) and 11 oxygen-containing VOCs (OVOCs)) and is referred to as OVOCl. Cylinder 2, made at the National Center for Atmospheric Research (NCAR), contained 4 components (one NMHC and three OVOCs) and is referred to as OVOC2. The mixtures were not prepared by either laboratory as primary standards but significant effort was applied to validate their concentrations by several different laboratories using several different techniques. The mixtures were prepared in high-pressure cylinders in the parts per million by volume (ppmv) range using calibrated syringe methods. Gas Chromatographic (GC) and 2,4-dinitrophenylhydrazine (DNPH) cartridge/high-pressure liquid Chromatographic (HPLC) systems were utilized in the calibration of the cylinders. GC detectors included the flame ionization detector (FID) and atomic emission detector (AED). Results obtained with the GC/FID systems for OVOCs were adjusted in terms of the effective carbon number (ECN), obtained from literature values, to correct for the reduced response of the FID for compounds containing oxygen, relative to compounds containing only carbon and hydrogen. Cylinder concentrations were derived and compared based on the ECN-adjusted FID results, the AED results, and the DNPH cartridge results. The various methods employed agreed to within approximately 15%. Both cylinders were stable (±4%) over a period of 2 years.

Comparison of gas chromatography-combustion-mass spectrometry and gas chromatography-flame ionization detector for the determination of fatty acid methyl esters in biodiesel without specific standards.

PubMed

Sobrado, Laura Alonso; Freije-Carrelo, Laura; Moldovan, Mariella; Encinar, Jorge Ruiz; Alonso, J Ignacio García

2016-07-29

GC-FID has been effectively used as a universal quantification technique for volatile organic compounds for a long time. In most cases, the use of the ECN allows for quantification by GC-FID without external calibration using only the response of a single internal standard. In this paper we compare the performance characteristics of GC-FID with those of post-column (13)C Isotope Dilution GC-Combustion-MS for the absolute quantification of organic compounds without the need for individual standards. For this comparison we have selected the quantification of FAMEs in biodiesel. The selection of the right internal standard was critical for GC-FID even when ECN were considered. On the other hand, the nature of the internal standard was not relevant when GC-Combustion-MS was employed. The proposed method was validated with the analysis of the certified reference material SRM 2772 and comparative data was obtained on real biodiesel samples. The analysis of the SRM 2772 biodiesel provided recoveries in the range 100.6-103.5% and 96.4-103.6% for GC-combustion-MS and GC-FID, respectively. The detection limit for GC-combustion-MS was found to be 4.2ng compound/g of injected sample. In conclusion, the quantitative performance of GC-Combustion-MS compared satisfactorily with that of GC-FID constituting a viable alternative for the quantification of organic compounds without the need for individual standards. Copyright © 2016 Elsevier B.V. All rights reserved.

Three subsystems of the inferior parietal cortex are differently affected in mild cognitive impairment.

PubMed

Liang, Peipeng; Wang, Zhiqun; Yang, Yanhui; Li, Kuncheng

2012-01-01

The Inferior parietal cortex (IPC), including the intraparietal sulcus (IPS), angular gyrus (AG), and supramarginal gyrus (SG), plays an important role in episodic memory, and is considered to be one of the specific neuroimaging markers in predicting the conversion of mild cognitive impairment (MCI) to Alzheimer's disease (AD). However, it is still unclear whether the connectivity of the IPC is impaired in MCI patients. In the present study, we used resting state fMRI to examine the functional connectivity of the three subdivisions of the IPC in MCI patients after controlling the impact of regional grey matter atrophy. It was found that, using IPS, AG, and SG as seeds of functional connectivity, three canonical functional networks could be correspondingly traced, i.e., executive control network (ECN), default mode network (DMN), and salience network (SN), and the three networks are differently altered in MCI patients. In contrast to the healthy controls, it was found that in MCI patients: 1) AG connectivity was significantly reduced within the DMN; 2) IPS showed decreased connectivity with the right inferior frontal gyrus while showing increased connectivity with the left frontal regions within the ECN; and 3) SG displayed decreased connectivity with a distribution of regions including the frontal and parietal regions, and increased connectivity with some sub-cortical areas within the SN. Moreover, the connectivity within the three networks was correlated with episodic memory and general cognitive impairment in MCI patients. These results extend well beyond the DMN, and further suggest that MCI is associated with alteration of large-scale functional brain networks.

Presurgical localization and spatial shift of resting state networks in patients with brain metastases.

PubMed

Ding, Ju-Rong; Zhu, Fangmei; Hua, Bo; Xiong, Xingzhong; Wen, Yuqiao; Ding, Zhongxiang; Thompson, Paul M

2018-04-02

Brain metastases are the most prevalent cerebral tumors. Resting state networks (RSNs) are involved in multiple perceptual and cognitive functions. Therefore, precisely localizing multiple RSNs may be extremely valuable before surgical resection of metastases, to minimize neurocognitive impairments. Here we aimed to investigate the reliability of independent component analysis (ICA) for localizing multiple RSNs from resting-state functional MRI (rs-fMRI) data in individual patients, and further evaluate lesion-related spatial shifts of the RSNs. Twelve patients with brain metastases and 14 healthy controls were recruited. Using an improved automatic component identification method, we successfully identified seven common RSNs, including: the default mode network (DMN), executive control network (ECN), dorsal attention network (DAN), language network (LN), sensorimotor network (SMN), auditory network (AN) and visual network (VN), in both individual patients and controls. Moreover, the RSNs in the patients showed a visible spatial shift compared to those in the controls, and the spatial shift of some regions was related to the tumor location, which may reflect a complicated functional mechanism - functional disruptions and reorganizations - caused by metastases. Besides, higher cognitive networks (DMN, ECN, DAN and LN) showed significantly larger spatial shifts than perceptual networks (SMN, AN and VN), supporting a functional dichotomy between the two network groups even in pathologic alterations associated with metastases. Overall, our findings provide evidence that ICA is a promising approach for presurgical localization of multiple RSNs from rs-fMRI data in individual patients. More attention should be paid to the spatial shifts of the RSNs before surgical resection.

28 CFR 549.73 - Appealing the fee.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Fees for Health Care Services § 549.73 Appealing the fee. You may seek review of issues related to health service fees through the Bureau's Administrative Remedy Program (see 28 CFR part 542). ...

28 CFR 549.73 - Appealing the fee.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Fees for Health Care Services § 549.73 Appealing the fee. You may seek review of issues related to health service fees through the Bureau's Administrative Remedy Program (see 28 CFR part 542). ...

Alternative Fuels Data Center

Science.gov Websites

Registration Fee Battery electric vehicle owners are required to pay an additional registration fee registration fee of $50. The Indiana Bureau of Motor Vehicles will determine new fee amounts every five years

Why Does the Law of One Price Fail? An Experiment on Index Mutual Funds*

PubMed Central

Choi, James J.; Laibson, David; Madrian, Brigitte C.

2009-01-01

We conduct an experiment to evaluate why individuals invest in high-fee index funds. In our experiments, subjects allocate $10,000 across four S&P 500 index funds and are rewarded for their portfolio’s subsequent return. Subjects overwhelmingly fail to minimize fees. We can reject the hypothesis that subjects buy high-fee index funds because of bundled non-portfolio services. Search costs for fees matter, but even when we eliminate these costs, fees are not minimized. Instead, subjects place high weight on annualized returns since inception. Fees paid decrease with financial literacy. Interestingly, subjects who choose high-fee funds sense they are making a mistake. PMID:20495662

78 FR 22281 - Notice of Intent To Collect Fees at the Henneberry House on Public Land in Beaverhead County...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-15

... local media. Fees would be collected as outlined in the field office's Fee Business Plan. The Henneberry... offset those ongoing costs. The BLM's mission for the Dillon Field Office Fee Business Plan (Project) is... addressed in the Dillon Field Office Recreation Fee Business Plan, prepared pursuant to the REA and BLM...

77 FR 25216 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-27

... efficient use of staff resources. The proposed Account Fee is substantially similar to the monthly account... Proposed Rule Change Relating to SQF and BONO Port Fees and Account Fees April 23, 2012. Pursuant to..., as well as to add an account fee (``Account Fee'') via Section 9, of the Options Rules portion of the...

7 CFR 160.204 - Fees for extra cost and hourly rate service.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Fees for extra cost and hourly rate service. 160.204... STORES REGULATIONS AND STANDARDS FOR NAVAL STORES Specific Fees Payable for Services Rendered § 160.204 Fees for extra cost and hourly rate service. The fees specified in §§ 160.201 and 160.202 apply to the...

76 FR 2163 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-12

..., Inc. Establishing Fees for Support and Maintenance of the Trading Floor, and Fees To Defray the Costs... proposes to establish fees for support and maintenance of the Trading Floor, and fees to defray the costs... Maker on the floor. The fee will be assessed to recover ongoing costs associated with the Trading Floor...

48 CFR 1552.217-72 - Option to extend the term of the contract-cost-plus-award-fee contract.

Code of Federal Regulations, 2010 CFR

2010-10-01

... of the contract-cost-plus-award-fee contract. 1552.217-72 Section 1552.217-72 Federal Acquisition...-award-fee contract. As prescribed in 1517.208(c), insert this contract clause in cost-plus-award-fee... Term of the Contract—Cost-Plus-Award-Fee Contract (APR 1984) (a) The Government has the option to...

77 FR 23313 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... Rule Change To Amend an Existing Fee Cap Program and Related Service Fee April 12, 2012. Pursuant to... fee cap program and a related service fee. The text of the proposed rule change is available on the... Rule Change 1. Purpose The Exchange currently has a fee cap program that, subject to certain exclusions...

78 FR 46643 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-01

... Change Amending the NYSE Arca Options Fee Schedule With Respect to Cap on Fees for Firm and Broker Dealer... (``Fee Schedule'') with respect to cap on fees for Firm and Broker Dealer open outcry executions. The... the cap on fees for Firm and Broker Dealer open outcry executions. Currently, there is a $100,000 cap...

76 FR 9383 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-17

... Effectiveness of Proposed Rule Change Relating to the CFLEX Surcharge Fee Cap February 10, 2011. Pursuant to... (``CBOE'' or ``Exchange'') proposes to amend its Fees Schedule to extend the CFLEX Surcharge Fee cap to... extend the cap on the CFLEX Surcharge Fee to all orders. The CFLEX Surcharge Fee would be charged up to...

76 FR 42757 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-19

... for Purposes of a Fee Cap and Sliding Scale July 13, 2011. Pursuant to Section 19(b)(1) of the...-Listed Options Fee Cap (the ``Fee Cap'') and the CBOE Proprietary Products Sliding Scale for Clearing... proposes to amend its Fees Schedule to apply the Fee Cap and the Sliding to orders of certain non-Trading...

An Analysis of Student Fees: The Roles of States and Institutions

ERIC Educational Resources Information Center

Kelchen, Robert

2016-01-01

Student fees make up 20% of the total cost of tuition and fees at the typical four-year public, yet little research has been conducted to examine institutional-level and state-level factors that may affect student fee charges. I use panel data to find that institutional selectivity and athletics spending do not influence student fee levels.…

Measuring users' response to higher recreation fees

Treesearch

Stephen D. Reiling; Hsiang Tai Cheng; Cheryl Trott

1992-01-01

One of the arguments against higher fees at publicly-provided recreational facilities is that higher fees may force low-income users to reduce their use of facilities more than high-income users, or force them to stop using the facilities altogether if they cannot afford the higher fee. Measuring the impact of higher fees on current users with different income levels...

78 FR 76358 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-17

... equity options to away markets. Today, the Exchange assesses a Non-Customer a $0.95 per contract Routing... transaction fee assessed. If the away market pays a rebate, the Routing Fee is $0.00 per contract.\\4\\ \\3... Fees, the transaction fee will continue to be based on the away market's actual transaction fee or...

12 CFR 414.1 - Collection of conference and other fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Collection of conference and other fees. 414.1 Section 414.1 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES CONFERENCE AND OTHER FEES § 414.1 Collection of conference and other fees. Ex-Im Bank may impose and collect reasonable fees to cover the costs...

75 FR 61252 - Proposed Information Collection (Create Payment Request for the VA Funding Fee Payment System (VA...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-04

... Payment Request for the VA Funding Fee Payment System (VA FFPS); A Computer Generated Funding Fee Receipt... Payment Request for the VA Funding Fee Payment System (VA FFPS); A Computer Generated Funding Fee Receipt... information through the Federal Docket Management System (FDMS) at http://www.Regulations.gov or to Nancy J...

75 FR 61859 - Proposed Information Collection (Create Payment Request for the VA Funding Fee Payment System (VA...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-06

... Payment Request for the VA Funding Fee Payment System (VA FFPS); A Computer Generated Funding Fee Receipt... Payment Request for the VA Funding Fee Payment System (VA FFPS); A Computer Generated Funding Fee Receipt... information through the Federal Docket Management System (FDMS) at http://www.Regulations.gov or to Nancy J...

22 CFR 1101.11 - Fees.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Fees. 1101.11 Section 1101.11 Foreign Relations INTERNATIONAL BOUNDARY AND WATER COMMISSION, UNITED STATES AND MEXICO, UNITED STATES SECTION PRIVACY ACT OF 1974 § 1101.11 Fees. (a) Under the Act, fees can only be charged for the cost of copying records. No fees may be charged for the time it take...

78 FR 59771 - Proposed Information Collection (Create Payment Request for the VA Funding Fee Payment System (VA...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-27

... Payment Request for the VA Funding Fee Payment System (VA FFPS); a Computer Generated Funding Fee Receipt.... Title: Create Payment Request for the VA Funding Fee Payment System (VA FFPS); A Computer Generated Funding Fee Receipt, VA Form 26-8986. OMB Control Number: 2900-0474. Type of Review: Revision of a...

43 CFR 3000.12 - What is the fee schedule for fixed fees?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What is the fee schedule for fixed fees... publication of a final rule in the Federal Register and will subsequently be posted on the BLM Web site (http... of lands 105 plus per acre nomination fee 0.11 Site license application 55 Assignment or transfer of...

78 FR 41174 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-09

... (Technology Fees) July 2, 2013. Pursuant to Section 19(b)(1) under the Securities Exchange Act of 1934 (the... Section V (Technology Fees) on the BOX Market LLC (``BOX'') options facility. Changes to the fee schedule... Exchange proposes to amend the Fee Schedule for trading on BOX to update and clarify the technology fees...

9 CFR 592.500 - Payment of fees and charges.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Payment of fees and charges. 592.500 Section 592.500 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Fees and Charges § 592.500 Payment of fees and charges. (a) Fees and charges for...

9 CFR 592.500 - Payment of fees and charges.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Payment of fees and charges. 592.500 Section 592.500 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Fees and Charges § 592.500 Payment of fees and charges. (a) Fees and charges for...

9 CFR 592.500 - Payment of fees and charges.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Payment of fees and charges. 592.500 Section 592.500 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Fees and Charges § 592.500 Payment of fees and charges. (a) Fees and charges for...

9 CFR 592.500 - Payment of fees and charges.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Payment of fees and charges. 592.500 Section 592.500 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS Fees and Charges § 592.500 Payment of fees and charges. (a) Fees and charges for...

75 FR 80090 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-21

... LLC To Establish Royalty Fees for Non-Customer Executions in Options Based on the KBW Bank Index... (``Fee Schedule'') to implement new royalty fees of $0.10 per contract associated with executions in... index, and will pay a fee to KBW on every contract traded on the Exchange. As with other royalty fees...

22 CFR 22.7 - Collection and return of fees.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Collection and return of fees. 22.7 Section 22...-DEPARTMENT OF STATE AND FOREIGN SERVICE § 22.7 Collection and return of fees. No fees other than those prescribed in the Schedule of Fees, § 22.1, or by or pursuant to an act of Congress, shall be charged or...

22 CFR 22.7 - Collection and return of fees.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Collection and return of fees. 22.7 Section 22...-DEPARTMENT OF STATE AND FOREIGN SERVICE § 22.7 Collection and return of fees. No fees other than those prescribed in the Schedule of Fees, § 22.1, or by or pursuant to an act of Congress, shall be charged or...

22 CFR 22.7 - Collection and return of fees.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Collection and return of fees. 22.7 Section 22...-DEPARTMENT OF STATE AND FOREIGN SERVICE § 22.7 Collection and return of fees. No fees other than those prescribed in the Schedule of Fees, § 22.1, or by or pursuant to an act of Congress, shall be charged or...

77 FR 27104 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... Implementing an Increase to the Login Fee Within the NYSE Amex Options Fee Schedule May 2, 2012. Pursuant to... Terms of Substance of the Proposed Rule Change The Exchange proposes to increase the login fee within... Exchange is proposing to increase the login fee within the Fee Schedule and to make this increase operative...

50 CFR 85.44 - Fee charges for use of facilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Fee charges for use of facilities. 85.44... Conditions on Use/Acceptance of Funds § 85.44 Fee charges for use of facilities. A maximum of a $5.00 fee may... with grant funds. If higher fees are charged, they must be justified before the proposal can be...

50 CFR 260.78 - Fees for additional copies of inspection certificates.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Fees for additional copies of inspection... Certification of Establishments and Fishery Products for Human Consumption Fees and Charges § 260.78 Fees for... those provided for in § 260.29, may be supplied to any interested party upon payment of a fee of $2.75...

43 CFR 2.19 - When will bureaus waive fees?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false When will bureaus waive fees? 2.19 Section... OF INFORMATION ACT Requests for Records under the FOIA § 2.19 When will bureaus waive fees? (a) Fees... section and appendix D to this part. The burden is on you to justify entitlement to a fee waiver. Requests...

32 CFR 701.47 - FOIA fees must be addressed in response letters.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PUBLICATION OF DEPARTMENT OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC FOIA Fees § 701.47 FOIA fees must be... 32 National Defense 5 2010-07-01 2010-07-01 false FOIA fees must be addressed in response letters... all fees which are charged and apprised of the “Category” in which they have been placed. For example...

10 CFR 9.41 - Requests for waiver or reduction of fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... publication fee; and (8) Describe any commercial or private interest the requester or any other party has in... 10 Energy 1 2010-01-01 2010-01-01 false Requests for waiver or reduction of fees. 9.41 Section 9... Requests for waiver or reduction of fees. (a)(1) The NRC will collect fees for searching for, reviewing...

12 CFR 502.60 - When will OTS adjust, add, waive, or eliminate a fee?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false When will OTS adjust, add, waive, or eliminate a fee? 502.60 Section 502.60 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY ASSESSMENTS AND FEES Fees § 502.60 When will OTS adjust, add, waive, or eliminate a fee? Under...

14 CFR 399.85 - Notice of baggage fees and other fees.

Code of Federal Regulations, 2014 CFR

2014-01-01

....85 Notice of baggage fees and other fees. (a) If a U. S. or foreign air carrier has a website... disclose any increase in its fee for carry-on or first and second checked bags and any change in the first and second checked bags or carry-on allowance for a passenger on the homepage of that website (e.g...

14 CFR 399.85 - Notice of baggage fees and other fees.

Code of Federal Regulations, 2012 CFR

2012-01-01

....85 Notice of baggage fees and other fees. (a) If a U. S. or foreign air carrier has a website... disclose any increase in its fee for carry-on or first and second checked bags and any change in the first and second checked bags or carry-on allowance for a passenger on the homepage of that website (e.g...

14 CFR 399.85 - Notice of baggage fees and other fees.

Code of Federal Regulations, 2013 CFR

2013-01-01

....85 Notice of baggage fees and other fees. (a) If a U. S. or foreign air carrier has a website... disclose any increase in its fee for carry-on or first and second checked bags and any change in the first and second checked bags or carry-on allowance for a passenger on the homepage of that website (e.g...

User fees for public health care services in Hungary: expectations, experience, and acceptability from the perspectives of different stakeholders.

PubMed

Baji, Petra; Pavlova, Milena; Gulácsi, László; Groot, Wim

2011-10-01

The introduction of user fees for health care services is a new phenomenon in Central-Eastern European Countries. In Hungary, user fees were first introduced in 2007, but abolished one year later after a referendum. The aim of our study is to describe the experiences and expectations of health system stakeholders in Hungary related to user fees as well as their approval of such fees. For our analysis we use both qualitative and quantitative data from focus-group discussions with health care consumers and physicians, and in-depth interviews with policy makers and health insurance representatives. Our findings suggest that the reasons behind the unpopularity of user fees might be (a) the rejection of the objectives of user fees defined by the government, (b) negative personal experiences with user fees, and (c) the general mistrust of the Hungarian population when it comes to the utilization of public resources. Successful policy implementation of user fees requires social consensus on the policy objectives, also there should be real improvements in health care provision noticeable for consumers, to assure the fees acceptance. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

7 CFR 4279.107 - Guarantee fees.

Code of Federal Regulations, 2013 CFR

2013-01-01

... guarantee fee may be reduced to 1 percent if the borrower's business supports value-added agriculture and... structural changes in its economic base. (b) Annual renewal fee. The annual renewal fee is paid once a year...

7 CFR 4279.107 - Guarantee fees.

Code of Federal Regulations, 2012 CFR

2012-01-01

... guarantee fee may be reduced to 1 percent if the borrower's business supports value-added agriculture and... structural changes in its economic base. (b) Annual renewal fee. The annual renewal fee is paid once a year...

7 CFR 4279.107 - Guarantee fees.

Code of Federal Regulations, 2011 CFR

2011-01-01

... guarantee fee may be reduced to 1 percent if the borrower's business supports value-added agriculture and... structural changes in its economic base. (b) Annual renewal fee. The annual renewal fee is paid once a year...

7 CFR 4279.107 - Guarantee fees.

Code of Federal Regulations, 2014 CFR

2014-01-01

... guarantee fee may be reduced to 1 percent if the borrower's business supports value-added agriculture and... structural changes in its economic base. (b) Annual renewal fee. The annual renewal fee is paid once a year...

37 CFR 102.31 - Fees.

Code of Federal Regulations, 2012 CFR

2012-07-01

... ADMINISTRATION DISCLOSURE OF GOVERNMENT INFORMATION Privacy Act § 102.31 Fees. The only fees to be charged to or.... (a) No fees shall be charged or collected for the following: Search for and retrieval of the records...